DCAMKL2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0 T789 Sugiyama POTEF A26C1B YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPVLLTEAT
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14979 T165 Sugiyama HNRNPDL HNRPDL JKTBP QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O15078 S1159 Sugiyama CEP290 BBS14 KIAA0373 NPHP6 LELEKNEMELKVEVSKLREIsDIARRQVEILNAQQQSRDKE
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43491 S529 Sugiyama EPB41L2 LTLGSKFRYsGRTQAQTRQAsTLIDRPAPHFERTSSKRVsR
O43602 S287 Sugiyama DCX DBCN LISX DENECRVMKGNPSATAGPKAsPtPQKtSAKsPGPMRRsKsP
O43602 T293 Sugiyama DCX DBCN LISX VMKGNPSATAGPKAsPtPQKtSAKsPGPMRRsKsPADsGND
O43615 S193 Sugiyama TIMM44 MIMT44 TIM44 TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60343 T488 Sugiyama TBC1D4 AS160 KIAA0603 IEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPVSDQ
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60664 S93 Sugiyama PLIN3 M6PRBP1 TIP47 AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60664 T216 Sugiyama PLIN3 M6PRBP1 TIP47 sEEWADNHLPLTDAELARIAtsLDGFDVAsVQQQRQEQSyF
O60739 T45 Sugiyama EIF1B AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75369 S1442 Sugiyama FLNB FLN1L FLN3 TABP TAP SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O94804 S514 Sugiyama STK10 LOK ESMDYGTNLSTDLSLNKEMGsLsIKDPKLYKKTLKRTRKFV
O94804 S516 Sugiyama STK10 LOK MDYGTNLSTDLSLNKEMGsLsIKDPKLYKKTLKRTRKFVVD
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95453 S557 Sugiyama PARN DAN KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04040 S515 Sugiyama CAT ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040 T511 Sugiyama CAT SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 T172 Sugiyama ANXA1 ANX1 LPC1 INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T55 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VPsGAstGIyEALELRDNDKtRYMGKGVSKAVEHINKtIAP
P06733 Y200 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EAMRIGAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILEN
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07814 T1506 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S615 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tyGWTANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIV
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 T83 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sKLDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLG
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08238 T94 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSGtKAFM
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S17 Sugiyama ALDOC ALDC ____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P0CG38 T789 Sugiyama POTEI YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
P0CG39 T752 Sugiyama POTEJ YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P10809 T61 Sugiyama HSPD1 HSP60 LQGVDLLADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVA
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 T379 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 AtKPLyVALAQRKEERQAHLtNQyMQRMASVRAVPNPVINP
P12004 S152 Sugiyama PCNA EySCVVKMPSGEFARICRDLsHIGDAVVIsCAKDGVKFSAs
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12277 S163 Sugiyama CKB CKBB PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE
P12814 T50 Sugiyama ACTN1 EKQQRKTFTAWCNsHLRKAGtQIENIEEDFRDGLKLMLLLE
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639 T484 Sugiyama EEF2 EF2 VPCGNIVGLVGVDQFLVKtGtIttFEHAHNMRVMKFsVsPV
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667 S135 Sugiyama PDIA4 ERP70 ERP72 IPVAKIDAtsAsVLAsRFDVsGyPtIKILKKGQAVDyEGsR
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13987 T85 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 WKFEHCNFNDVtTRLRENELtyyCCKKDLCNFNEQLENGGT
P14314 S451 Sugiyama PRKCSH G19P1 KLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSAMKyEQGtGC
P14314 T444 Sugiyama PRKCSH G19P1 VYRLCPFKLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSAMK
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880 T202 Sugiyama RPS2 RPS4 CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17655 T464 Sugiyama CAPN2 CANPL2 TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P17980 T163 Sugiyama PSMC3 TBP1 EKLKPGDLVGVNKDSyLILEtLPtEyDsRVKAMEVDERPtE
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 T584 Sugiyama NCL PNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTDR
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P21333 S2152 Sugiyama FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333 S2158 Sugiyama FLNA FLN FLN1 GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22059 S240 Sugiyama OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23381 S358 Sugiyama WARS1 IFI53 WARS WRS TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs
P23381 T301 Sugiyama WARS1 IFI53 WARS WRS PAIQAAPSFSNSFPQIFRDRtDIQCLIPCAIDQDPyFRMTR
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25054 S2724 Sugiyama APC DP2.5 QNVGNGSVPMRTVGLENRLNsFIQVDAPDQKGTEIKPGQNN
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26373 T24 Sugiyama RPL13 BBC1 OK/SW-cl.46 SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26447 S14 Sugiyama S100A4 CAPL MTS1 _______MACPLEKALDVMVstFHKYSGKEGDKFKLNKSEL
P26447 T15 Sugiyama S100A4 CAPL MTS1 ______MACPLEKALDVMVstFHKYSGKEGDKFKLNKSELK
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27816 T828 Sugiyama MAP4 AKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVKK
P28066 S159 Sugiyama PSMA5 VALLFGGVDEKGPQLFHMDPsGtFVQCDARAIGsAsEGAQs
P28066 T161 Sugiyama PSMA5 LLFGGVDEKGPQLFHMDPsGtFVQCDARAIGsAsEGAQssL
P29401 S305 Sugiyama TKT LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P30040 T62 Sugiyama ERP29 C12orf8 ERP28 DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P30086 T167 Sugiyama PEBP1 PBP PEBP GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30101 S474 Sugiyama PDIA3 ERP57 ERP60 GRP58 yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30101 S98 Sugiyama PDIA3 ERP57 ERP60 GRP58 VPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGP
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32929 S56 Sugiyama CTH AVVPPISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVA
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35579 S1304 Sugiyama MYH9 NVtGLLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQK
P35579 S1915 Sugiyama MYH9 KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579 T1764 Sugiyama MYH9 NtELINDRLKKANLQIDQINtDLNLERSHAQKNENARQQLE
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P37198 S418 Sugiyama NUP62 SQQKELEDLLsPLEELVKEQsGtIyLQHADEEREKTYKLAE
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38606 S384 Sugiyama ATP6V1A ATP6A1 ATP6V1A1 VPP2 RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T480 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 RNTTIPTKKSQVFstAADGQtQVEIKVCQGEREMAGDNKLL
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P39687 T143 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 CEVtNLNDyRENVFKLLPQLtyLDGyDRDDKEAPDsDAEGY
P40818 S718 Sugiyama USP8 KIAA0055 UBPY AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P40926 T179 Sugiyama MDH2 GVYNPNKIFGVTTLDIVRANtFVAELKGLDPARVNVPVIGG
P40939 T418 Sugiyama HADHA HADH DRGQQQVFKGLNDKVKKKALtSFERDSIFSNLTGQLDyQGF
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41227 T152 Sugiyama NAA10 ARD1 ARD1A TE2 EVEPKyyADGEDAyAMKRDLtQMADELRRHLELKEKGRHVV
P41567 T45 Sugiyama EIF1 SUI1 AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P42166 T528 Sugiyama TMPO LAP2 QVDRQLPSLACKYPVSSREAtQILSVPKVDDEILGFISEAT
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43121 T100 Sugiyama MCAM MUC18 QGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERIFLCQGKR
P43121 T104 Sugiyama MCAM MUC18 EPGEYEQRLsLQDRGAtLALtQVtPQDERIFLCQGKRPRSQ
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P46940 S1448 Sugiyama IQGAP1 KIAA0051 AIRDAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGLKKLTE
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368 T484 Sugiyama CCT3 CCTG TRIC5 tSLRAKHtQENCEtWGVNGEtGtLVDMKELGIWEPLAVKLQ
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49790 S607 Sugiyama NUP153 KtPPEDCEGPFRPAEILKEGsVLDILKsPGFAsPKIDSVAA
P50395 T408 Sugiyama GDI2 RABGDIB VPKDLGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsE
P50395 T413 Sugiyama GDI2 RABGDIB GtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFEE
P50454 S141 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50897 S262 Sugiyama PPT1 CLN1 PPT EWFGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVF
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597 S265 Sugiyama HNRNPF HNRPF EySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQs
P52789 S889 Sugiyama HK2 PHFAKVMHETVKDLAPKCDVsFLQsEDGSGKGAALITAVAC
P52948 S625 Sugiyama NUP98 ADAR2 LNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDENH
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53634 T431 Sugiyama CTSC CPPI GYGTDSASGMDYWIVKNsWGtGWGENGyFRIRRGtDECAIE
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54105 T36 Sugiyama CLNS1A CLCI ICLN LLRQQPDTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55196 S216 Sugiyama AFDN AF6 MLLT4 SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S198 Sugiyama TPI1 TPI TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174 S204 Sugiyama TPI1 TPI EVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQ
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T303 Sugiyama ACTB MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T89 Sugiyama ACTB YPIEHGIVTNWDDMEKIWHHtFyNELRVAPEEHPVLLtEAP
P61081 T176 Sugiyama UBE2M UBC12 NRRLFEQNVQRSMRGGyIGstyFERCLK_____________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T303 Sugiyama ACTG1 ACTG MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T89 Sugiyama ACTG1 ACTG YPIEHGIVTNWDDMEKIWHHtFyNELRVAPEEHPVLLtEAP
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T91 Sugiyama ACTC1 ACTC yPIEHGIItNWDDMEKIWHHtFyNELRVAPEEHPtLLTEAP
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T91 Sugiyama ACTA1 ACTA yPIEHGIItNWDDMEKIWHHtFyNELRVAPEEHPtLLTEAP
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P78347 S722 Sugiyama GTF2I BAP135 WBSCR6 RtPtQtNGsNVPFKPRGREFsFEAWNAKITDLKQKVENLFN
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98082 S723 Sugiyama DAB2 DOC2 DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF
Q00839 T532 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 TWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtGKL
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02790 T42 Sugiyama FKBP4 FKBP52 GVDIsPKQDEGVLKVIKREGtGTEMPMIGDRVFVHYTGWLL
Q02878 T213 Sugiyama RPL6 TXREB1 FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q02952 S248 Sugiyama AKAP12 AKAP250 KESEPKQSTEKPEETLKREQsHAEIsPPAESGQAVEECKEE
Q04760 T35 Sugiyama GLO1 AALSCCSDADPSTKDFLLQQtMLRVKDPKKSLDFyTRVLGM
Q04917 T31 Sugiyama YWHAH YWHA1 ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12906 S20 Sugiyama ILF3 DRBF MPHOSPH4 NF90 _MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtER
Q13098 S474 Sugiyama GPS1 COPS1 CSN1 MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___
Q13111 S806 Sugiyama CHAF1A CAF CAF1P150 PSEDAAIPSKSRLKRLISENsVYEKRPDFRMCWYVHPQVLQ
Q13136 S338 Sugiyama PPFIA1 LIP1 MEERITTLEKRYLAAQREATsVHDLNDKLENEIANKDSMHR
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13347 T201 Sugiyama EIF3I EIF3S2 TRIP1 LVNVKEHSRQINDIQLsRDMtMFVtASKDNTAKLFDsttLE
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q13642 T79 Sugiyama FHL1 SLIM1 RFWHDtCFRCAKCLHPLANEtFVAKDNKILCNKCTTREDsP
Q13765 T119 Sugiyama NACA HSD48 SKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAA
Q14118 T522 Sugiyama DAG1 HIDRVDAWVGTYFEVKIPSDtFyDHEDTTTDKLKLTLKLRE
Q14152 S215 Sugiyama EIF3A EIF3S10 KIAA0139 RKLCDNLRMHLsQIQRHHNQstAINLNNPESQsMHLETRLV
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14192 T234 Sugiyama FHL2 DRAL SLIM3 CDLyAKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKC
Q14257 T301 Sugiyama RCN2 ERC55 KKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL____
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14677 S210 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 KNKSAFPFSDKLGELsDKIGstIDDtIsKFRRKDREDsPER
Q14966 S1228 Sugiyama ZNF638 NP220 ZFML DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15084 S389 Sugiyama PDIA6 ERP5 P5 TXNDC7 FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15172 S472 Sugiyama PPP2R5A EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15293 T318 Sugiyama RCN1 RCN EKLTKEEILENWNMFVGsQAtNyGEDLtKNHDEL_______
Q15427 T14 Sugiyama SF3B4 SAP49 _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16531 T1125 Sugiyama DDB1 XAP1 MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q16719 S443 Sugiyama KYNU VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q16719 Y441 Sugiyama KYNU RGVVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsA
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q53H82 T97 Sugiyama LACTB2 CGI-83 HWHRDHSGGIGDICKSINNDtTyCIKKLPRNPQREEIIGNG
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 S488 Sugiyama HSP90AB3P HSP90BC TYGWTANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIM
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5BKZ1 Y93 Sugiyama ZNF326 ZIRD PYESyDsRsSLGGRDLYRsGyGFNEPEQSRFGGSYGGRFES
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SSJ5 S227 Sugiyama HP1BP3 LKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRKNR
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5T035 S68 Sugiyama FAM120A2P C9orf129 EPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPINP
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6P1J9 S212 Sugiyama CDC73 C1orf28 HRPT2 KKRSTIKTDLDDDITALKQRsFVDAEVDVTRDIVSRERVWR
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3 T789 Sugiyama POTEE A26C1A POTE2 YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86WR0 S187 Sugiyama CCDC25 KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IXH6 S208 Sugiyama TP53INP2 C20orf110 DOR PINH AVQRQNRARESRPRRSKNQSsFIyQPCQRQFNY________
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N568 S111 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 ISSDRFRSFDALLIELTRSLsDNVNLPQGVRtIytIDGsRK
Q8N568 S129 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 SLsDNVNLPQGVRtIytIDGsRKVtsLDELLEGEsyVCASN
Q8N568 S134 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 VNLPQGVRtIytIDGsRKVtsLDELLEGEsyVCASNEPFRK
Q8N568 S143 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 IytIDGsRKVtsLDELLEGEsyVCASNEPFRKVDYTKNINP
Q8N568 S166 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 CASNEPFRKVDYTKNINPNWsVNIKGGtsRALAAAssVKsE
Q8N568 S174 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 KVDYTKNINPNWsVNIKGGtsRALAAAssVKsEVKESKDFI
Q8N568 S181 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 INPNWsVNIKGGtsRALAAAssVKsEVKESKDFIKPKLVTV
Q8N568 S182 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 NPNWsVNIKGGtsRALAAAssVKsEVKESKDFIKPKLVTVI
Q8N568 S185 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 WsVNIKGGtsRALAAAssVKsEVKESKDFIKPKLVTVIRSG
Q8N568 S223 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 RSGVKPRKAVRILLNKKtAHsFEQVLtDITEAIKLDSGVVK
Q8N568 S286 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 FIACGPEKFRyAQDDFVLDHsECRVLKSSYSRSSAVKYSGS
Q8N568 S362 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 PTsPGsFRGLKQISAHGRsssNVNGGPELDRCIsPEGVNGN
Q8N568 S375 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 SAHGRsssNVNGGPELDRCIsPEGVNGNRCsESSTLLEKYK
Q8N568 S385 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 NGGPELDRCIsPEGVNGNRCsESSTLLEKYKIGKVIGDGNF
Q8N568 S442 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 LKIIDKAKCCGKEHLIENEVsILRRVKHPNIIMLVEEMETA
Q8N568 S47 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 APSSSGGSSSSGPKGNGLIPsPAHsAHCsFyRTRtLQALSs
Q8N568 S51 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 SGGSSSSGPKGNGLIPsPAHsAHCsFyRTRtLQALSsEKKA
Q8N568 S55 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 SSSGPKGNGLIPsPAHsAHCsFyRTRtLQALSsEKKAKKAR
Q8N568 S67 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 sPAHsAHCsFyRTRtLQALSsEKKAKKARFYRNGDRYFKGL
Q8N568 T122 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 LLIELTRSLsDNVNLPQGVRtIytIDGsRKVtsLDELLEGE
Q8N568 T125 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 ELTRSLsDNVNLPQGVRtIytIDGsRKVtsLDELLEGEsyV
Q8N568 T133 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 NVNLPQGVRtIytIDGsRKVtsLDELLEGEsyVCASNEPFR
Q8N568 T173 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 RKVDYTKNINPNWsVNIKGGtsRALAAAssVKsEVKESKDF
Q8N568 T220 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 TVIRSGVKPRKAVRILLNKKtAHsFEQVLtDITEAIKLDSG
Q8N568 T229 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 RKAVRILLNKKtAHsFEQVLtDITEAIKLDSGVVKRLCTLD
Q8N568 T254 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 AIKLDSGVVKRLCTLDGKQVtCLQDFFGDDDVFIACGPEKF
Q8N568 T485 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 LFLVMELVKGGDLFDAITSStKYTERDGSAMVYNLANALRY
Q8N568 T61 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 GNGLIPsPAHsAHCsFyRTRtLQALSsEKKAKKARFYRNGD
Q8N568 Y124 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 IELTRSLsDNVNLPQGVRtIytIDGsRKVtsLDELLEGEsy
Q8N568 Y144 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 ytIDGsRKVtsLDELLEGEsyVCASNEPFRKVDYTKNINPN
Q8N568 Y276 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 LQDFFGDDDVFIACGPEKFRyAQDDFVLDHsECRVLKSSYS
Q8N568 Y57 Sugiyama DCLK2 DCAMKL2 DCDC3B DCK2 SGPKGNGLIPsPAHsAHCsFyRTRtLQALSsEKKAKKARFY
Q8N6T3 T292 Sugiyama ARFGAP1 ARF1GAP VsQLAsKVQGVGSKGWRDVttFFsGKAEGPLDsPSEGHSyQ
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND56 S368 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EGNADEEDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEE
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q8WWI1 S704 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q92974 T802 Sugiyama ARHGEF2 KIAA0651 LFP40 sRDGEAGRAGAAPVAPEKQAtELALLQRQHALLQEELRRCR
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q93100 S27 Sugiyama PHKB LTAEVSWKVLERRARTKRsGsVyEPLKsINLPRPDNETLWD
Q96B36 T233 Sugiyama AKT1S1 PRAS40 PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96CT7 S122 Sugiyama CCDC124 DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96L92 S51 Sugiyama SNX27 KIAA0488 My014 AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q99613 S754 Sugiyama EIF3C EIF3S8 REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99613 T880 Sugiyama EIF3C EIF3S8 AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99614 S155 Sugiyama TTC1 TPR1 AESSYSRALEMCPSCFQKERsILFSNRAAARMKQDKKEMAI
Q99615 S94 Sugiyama DNAJC7 TPR2 TTC2 MLGRFREALGDAQQsVRLDDsFVRGHLREGKCHLSLGNAMA
Q99733 S53 Sugiyama NAP1L4 NAP2 QNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQL
Q99733 Y55 Sugiyama NAP1L4 NAP2 PRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQLQV
Q99832 T300 Sugiyama CCT7 CCTH NIP7-1 KIHHSGAKVVLSKLPIGDVAtQyFADRDMFCAGRVPEEDLK
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q99848 S107 Sugiyama EBNA1BP2 EBP2 APQNKDQKAVDPEDDFQREMsFyRQAQAAVLAVLPRLHQLK
Q99848 Y109 Sugiyama EBNA1BP2 EBP2 QNKDQKAVDPEDDFQREMsFyRQAQAAVLAVLPRLHQLKVP
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BT09 T204 Sugiyama CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409 HQEEDLTEFLCANHVLKGKDtsCLAEQWsGKKGDTAALGGK
Q9BYX7 T89 Sugiyama POTEKP ACTBL3 FKSG30 YPMEHGIITNWDDMEKIWHHtFyNELRVAPEEHPILLTEAP
Q9GZZ9 S45 Sugiyama UBA5 UBE1DC1 LQVPRSGDGGGGRVRIEKMssEVVDSNPysRLMALKRMGIV
Q9H2G2 S341 Sugiyama SLK KIAA0204 STK2 EDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACILE
Q9H2G2 T527 Sugiyama SLK KIAA0204 STK2 GEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQKDVIsNtsD
Q9H3N1 S270 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H788 S129 Sugiyama SH2D4A PPP1R38 SH2A EAEEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKDIWKKV
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NUU7 T21 Sugiyama DDX19A DDX19L MATDSWALAVDEQEAAVKSMtNLQIKEEKVKADTNGIIKTS
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9NZB2 S419 Sugiyama FAM120A C9orf10 KIAA0183 OSSA EPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPINP
Q9NZL9 S9 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 ____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UI30 S125 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 RMFPISRGIPNMLLsEEEtEs____________________
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UKX7 T235 Sugiyama NUP50 NPAP60L PRO1146 VAAEtQsPsLFGstKLQQEStFLFHGNKTEDtPDKKMEVAS
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S1326 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 GGPHFsPEHKELsNsPLRENsFGsPLEFRNsGPLGTEMNtG
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 T200 Sugiyama PA2G4 EBP1 TPIEGMLSHQLKQHVIDGEKtIIQNPTDQQKKDHEKAEFEV
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.297141e-10 9.639 0 0
Axon guidance R-HSA-422475 1.041195e-09 8.982 0 0
Chromatin modifying enzymes R-HSA-3247509 3.562311e-09 8.448 0 0
HSF1-dependent transactivation R-HSA-3371571 4.042584e-09 8.393 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.981221e-09 8.223 0 0
Cellular Senescence R-HSA-2559583 8.144057e-09 8.089 0 0
Nervous system development R-HSA-9675108 1.487017e-08 7.828 0 0
Chromatin organization R-HSA-4839726 2.289972e-08 7.640 0 0
Cell Cycle, Mitotic R-HSA-69278 3.097216e-08 7.509 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.664108e-08 7.436 0 0
Signal Transduction R-HSA-162582 4.424502e-08 7.354 0 0
Cell Cycle Checkpoints R-HSA-69620 4.953081e-08 7.305 0 0
Apoptotic execution phase R-HSA-75153 2.259984e-07 6.646 0 0
NRAGE signals death through JNK R-HSA-193648 2.619995e-07 6.582 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.060190e-07 6.391 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.983032e-07 6.303 0 0
Attenuation phase R-HSA-3371568 5.407893e-07 6.267 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.370150e-07 6.270 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.748694e-07 6.171 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.957308e-07 6.099 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.931687e-06 5.714 0 0
M Phase R-HSA-68886 2.153332e-06 5.667 0 0
Cell-Cell communication R-HSA-1500931 2.243800e-06 5.649 0 0
Regulation of TP53 Activity R-HSA-5633007 2.366219e-06 5.626 0 0
Death Receptor Signaling R-HSA-73887 3.410663e-06 5.467 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.937230e-06 5.405 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.140880e-06 5.383 0 0
Cellular responses to stress R-HSA-2262752 5.239341e-06 5.281 0 0
Meiotic synapsis R-HSA-1221632 6.797841e-06 5.168 0 0
Cellular responses to stimuli R-HSA-8953897 7.784782e-06 5.109 0 0
HATs acetylate histones R-HSA-3214847 9.610997e-06 5.017 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.189138e-05 4.925 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.189138e-05 4.925 0 0
Cellular response to heat stress R-HSA-3371556 1.261967e-05 4.899 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.323330e-05 4.878 0 0
Cell junction organization R-HSA-446728 1.411043e-05 4.850 0 0
Diseases of programmed cell death R-HSA-9645723 1.568989e-05 4.804 0 0
DNA Double Strand Break Response R-HSA-5693606 1.701143e-05 4.769 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.949651e-05 4.710 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.136531e-05 4.670 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.136531e-05 4.670 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.164019e-05 4.665 0 0
FLT3 Signaling R-HSA-9607240 2.252670e-05 4.647 0 0
HDACs deacetylate histones R-HSA-3214815 3.152314e-05 4.501 0 0
Homology Directed Repair R-HSA-5693538 3.104633e-05 4.508 0 0
Packaging Of Telomere Ends R-HSA-171306 3.359934e-05 4.474 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.281748e-05 4.484 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.625542e-05 4.441 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.828813e-05 4.417 0 0
Apoptosis R-HSA-109581 4.418317e-05 4.355 0 0
Signaling by ERBB2 R-HSA-1227986 4.503253e-05 4.346 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.699260e-05 4.328 0 0
Rab regulation of trafficking R-HSA-9007101 5.265152e-05 4.279 0 0
Programmed Cell Death R-HSA-5357801 5.541052e-05 4.256 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.867791e-05 4.232 0 0
Deubiquitination R-HSA-5688426 6.222719e-05 4.206 0 0
Post NMDA receptor activation events R-HSA-438064 6.312909e-05 4.200 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.458847e-05 4.190 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.939501e-05 4.159 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.492667e-05 4.125 0 0
Metalloprotease DUBs R-HSA-5689901 7.499188e-05 4.125 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.535985e-05 4.069 0 0
G alpha (12/13) signalling events R-HSA-416482 8.822603e-05 4.054 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.010342e-05 4.045 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.671228e-05 4.015 0 0
Nucleosome assembly R-HSA-774815 9.736786e-05 4.012 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.736786e-05 4.012 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.077472e-04 3.968 0 0
HSF1 activation R-HSA-3371511 1.100221e-04 3.959 0 0
Signaling by ROBO receptors R-HSA-376176 1.140415e-04 3.943 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.381132e-04 3.860 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.482151e-04 3.829 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.432181e-04 3.844 0 0
Meiosis R-HSA-1500620 1.629080e-04 3.788 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.761149e-04 3.754 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.935828e-04 3.713 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.935828e-04 3.713 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.856673e-04 3.731 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.966681e-04 3.706 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.966681e-04 3.706 0 0
DNA methylation R-HSA-5334118 2.125269e-04 3.673 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.182506e-04 3.661 0 0
Signaling by ALK in cancer R-HSA-9700206 2.182506e-04 3.661 0 0
RNA Polymerase II Transcription R-HSA-73857 2.220100e-04 3.654 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.352444e-04 3.628 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.365535e-04 3.626 0 0
DAG and IP3 signaling R-HSA-1489509 2.491780e-04 3.603 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.584646e-04 3.588 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.609755e-04 3.583 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.732390e-04 3.563 0 0
G2/M Checkpoints R-HSA-69481 2.948603e-04 3.530 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.018030e-04 3.520 0 0
Gene expression (Transcription) R-HSA-74160 3.212537e-04 3.493 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.305321e-04 3.481 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.414115e-04 3.467 0 0
MAPK family signaling cascades R-HSA-5683057 3.549189e-04 3.450 0 0
Defective pyroptosis R-HSA-9710421 3.766013e-04 3.424 0 0
Ub-specific processing proteases R-HSA-5689880 3.818510e-04 3.418 0 0
Cleavage of the damaged purine R-HSA-110331 3.976446e-04 3.401 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.077892e-04 3.390 0 0
Signaling by VEGF R-HSA-194138 4.083786e-04 3.389 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.115668e-04 3.386 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.324680e-04 3.364 0 0
Adherens junctions interactions R-HSA-418990 4.207892e-04 3.376 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.473525e-04 3.349 0 0
Cell-cell junction organization R-HSA-421270 4.552993e-04 3.342 0 0
Regulation of PTEN localization R-HSA-8948747 4.599488e-04 3.337 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.816982e-04 3.317 0 0
Mitotic Prometaphase R-HSA-68877 4.838113e-04 3.315 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.946338e-04 3.306 0 0
Depurination R-HSA-73927 5.188708e-04 3.285 0 0
Mitotic Anaphase R-HSA-68882 5.521007e-04 3.258 0 0
Membrane Trafficking R-HSA-199991 6.081996e-04 3.216 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.125433e-04 3.213 0 0
Generic Transcription Pathway R-HSA-212436 6.695625e-04 3.174 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.708174e-04 3.173 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.733415e-04 3.172 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.051495e-04 3.152 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.944967e-04 3.158 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.255526e-04 3.139 0 0
Depyrimidination R-HSA-73928 7.255526e-04 3.139 0 0
EPH-Ephrin signaling R-HSA-2682334 7.822848e-04 3.107 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.160942e-04 3.088 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.474829e-04 3.072 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.401989e-04 3.027 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.224616e-04 3.035 0 0
Separation of Sister Chromatids R-HSA-2467813 9.662586e-04 3.015 0 0
Muscle contraction R-HSA-397014 9.420699e-04 3.026 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.204469e-03 2.919 0 0
CREB phosphorylation R-HSA-199920 1.204469e-03 2.919 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.206402e-03 2.919 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.016495e-03 2.993 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.092275e-03 2.962 0 0
Ion homeostasis R-HSA-5578775 1.249866e-03 2.903 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.063768e-03 2.973 0 0
ESR-mediated signaling R-HSA-8939211 1.115163e-03 2.953 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.092275e-03 2.962 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.020744e-03 2.991 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.960060e-04 3.002 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.216747e-03 2.915 0 0
Netrin-1 signaling R-HSA-373752 1.152319e-03 2.938 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.223697e-03 2.912 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.223697e-03 2.912 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.109116e-03 2.955 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.154660e-03 2.938 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.200082e-03 2.921 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.200082e-03 2.921 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.200082e-03 2.921 0 0
Meiotic recombination R-HSA-912446 9.985368e-04 3.001 0 0
L1CAM interactions R-HSA-373760 1.117129e-03 2.952 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.167843e-03 2.933 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.069849e-03 2.971 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.235387e-03 2.908 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.092275e-03 2.962 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.259510e-03 2.900 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.386269e-03 2.858 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.386269e-03 2.858 0 0
Long-term potentiation R-HSA-9620244 1.446156e-03 2.840 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.512507e-03 2.820 0 0
Signaling by WNT R-HSA-195721 1.587743e-03 2.799 0 0
Reproduction R-HSA-1474165 1.605258e-03 2.794 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.685792e-03 2.773 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.777647e-03 2.750 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.777647e-03 2.750 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.777647e-03 2.750 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.777647e-03 2.750 0 0
Signaling by RAS mutants R-HSA-6802949 1.777647e-03 2.750 0 0
Calmodulin induced events R-HSA-111933 1.959476e-03 2.708 0 0
CaM pathway R-HSA-111997 1.959476e-03 2.708 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.987015e-03 2.702 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.987015e-03 2.702 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.038905e-03 2.691 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.121574e-03 2.673 0 0
Recycling pathway of L1 R-HSA-437239 2.185466e-03 2.660 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.269691e-03 2.644 0 0
Striated Muscle Contraction R-HSA-390522 2.333186e-03 2.632 0 0
Pexophagy R-HSA-9664873 2.385639e-03 2.622 0 0
Selective autophagy R-HSA-9663891 2.526664e-03 2.597 0 0
G2/M Transition R-HSA-69275 2.570287e-03 2.590 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.912184e-03 2.536 0 0
mRNA 3'-end processing R-HSA-72187 2.679970e-03 2.572 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.671210e-03 2.573 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.634085e-03 2.579 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.912184e-03 2.536 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.888846e-03 2.539 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.888846e-03 2.539 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.641648e-03 2.578 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.956285e-03 2.529 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.966900e-03 2.528 0 0
DNA Repair R-HSA-73894 3.001466e-03 2.523 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.003321e-03 2.522 0 0
MAP kinase activation R-HSA-450294 3.145486e-03 2.502 0 0
Regulation of CDH1 Function R-HSA-9764561 3.196629e-03 2.495 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.196629e-03 2.495 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.409269e-03 2.467 0 0
Mitotic Prophase R-HSA-68875 3.258892e-03 2.487 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.582358e-03 2.446 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.647626e-03 2.438 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.647626e-03 2.438 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.794944e-03 2.421 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.865691e-03 2.413 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.870783e-03 2.412 0 0
Rap1 signalling R-HSA-392517 3.986032e-03 2.399 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.201523e-03 2.377 0 0
Late endosomal microautophagy R-HSA-9615710 4.218114e-03 2.375 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.240808e-03 2.373 0 0
Semaphorin interactions R-HSA-373755 4.397816e-03 2.357 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.428160e-03 2.354 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.457374e-03 2.351 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.457374e-03 2.351 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.545826e-03 2.342 0 0
Autophagy R-HSA-9612973 4.748312e-03 2.323 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.058038e-03 2.296 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.093548e-03 2.293 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.548117e-03 2.256 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.786627e-03 2.238 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.553467e-03 2.255 0 0
NF-kB is activated and signals survival R-HSA-209560 5.553467e-03 2.255 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.553467e-03 2.255 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.582211e-03 2.253 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.147763e-03 2.211 0 0
Co-stimulation by CD28 R-HSA-389356 5.688485e-03 2.245 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.169300e-03 2.210 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.553467e-03 2.255 0 0
Signaling by Hippo R-HSA-2028269 6.213754e-03 2.207 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.761415e-03 2.239 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.533635e-03 2.257 0 0
PLC beta mediated events R-HSA-112043 6.256981e-03 2.204 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.416427e-03 2.193 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.416427e-03 2.193 0 0
Signaling by Interleukins R-HSA-449147 6.444210e-03 2.191 0 0
Trafficking of AMPA receptors R-HSA-399719 6.715368e-03 2.173 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.746886e-03 2.171 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.969423e-03 2.157 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.013811e-03 2.154 0 0
p75NTR signals via NF-kB R-HSA-193639 7.124046e-03 2.147 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.124046e-03 2.147 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.124046e-03 2.147 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.124046e-03 2.147 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.414582e-03 2.130 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.638851e-03 2.117 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.684107e-03 2.114 0 0
Neurodegenerative Diseases R-HSA-8863678 7.684107e-03 2.114 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.777782e-03 2.109 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.338912e-03 2.079 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.016028e-03 2.096 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.183466e-03 2.037 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.183466e-03 2.037 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.344620e-03 2.079 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.280246e-03 2.082 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.280246e-03 2.082 0 0
FOXO-mediated transcription R-HSA-9614085 7.897580e-03 2.103 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.016028e-03 2.096 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.883515e-03 2.103 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.982304e-03 2.047 0 0
Peptide chain elongation R-HSA-156902 8.303616e-03 2.081 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.100327e-03 2.091 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.747258e-03 2.058 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.747258e-03 2.058 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.344620e-03 2.079 0 0
Ca-dependent events R-HSA-111996 8.389650e-03 2.076 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.722034e-03 2.012 0 0
Negative regulation of FLT3 R-HSA-9706369 9.722034e-03 2.012 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.010718e-02 1.995 0 0
Aggrephagy R-HSA-9646399 1.020490e-02 1.991 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.027152e-02 1.988 0 0
RET signaling R-HSA-8853659 1.029323e-02 1.987 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.030743e-02 1.987 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.075513e-02 1.968 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.117581e-02 1.952 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.121882e-02 1.950 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.121882e-02 1.950 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.121882e-02 1.950 0 0
RMTs methylate histone arginines R-HSA-3214858 1.192181e-02 1.924 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.195428e-02 1.922 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.221566e-02 1.913 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.241032e-02 1.906 0 0
Interleukin-17 signaling R-HSA-448424 1.243723e-02 1.905 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.412959e-02 1.850 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.386298e-02 1.858 0 0
PECAM1 interactions R-HSA-210990 1.269108e-02 1.897 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.269108e-02 1.897 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.484515e-02 1.828 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.501352e-02 1.824 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.437833e-02 1.842 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.297700e-02 1.887 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.420797e-02 1.847 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.489357e-02 1.827 0 0
Macroautophagy R-HSA-1632852 1.510613e-02 1.821 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.504798e-02 1.823 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.452449e-02 1.838 0 0
Signaling by NTRKs R-HSA-166520 1.318794e-02 1.880 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.412959e-02 1.850 0 0
G-protein mediated events R-HSA-112040 1.501352e-02 1.824 0 0
RAF activation R-HSA-5673000 1.515690e-02 1.819 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.519302e-02 1.818 0 0
UCH proteinases R-HSA-5689603 1.525489e-02 1.817 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.525489e-02 1.817 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.527876e-02 1.816 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.584497e-02 1.800 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.608632e-02 1.794 0 0
Amyloid fiber formation R-HSA-977225 1.624619e-02 1.789 0 0
Activation of RAC1 R-HSA-428540 1.777475e-02 1.750 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.799662e-02 1.745 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.799662e-02 1.745 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.799662e-02 1.745 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.818628e-02 1.740 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.830132e-02 1.738 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.864632e-02 1.729 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.864632e-02 1.729 0 0
RNA Polymerase I Transcription R-HSA-73864 1.948807e-02 1.710 0 0
Signaling by FGFR4 R-HSA-5654743 2.014588e-02 1.696 0 0
TBC/RABGAPs R-HSA-8854214 2.014588e-02 1.696 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.017597e-02 1.695 0 0
DCC mediated attractive signaling R-HSA-418885 2.030909e-02 1.692 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.066824e-02 1.685 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.119212e-02 1.674 0 0
Ephrin signaling R-HSA-3928664 2.181259e-02 1.661 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.205766e-02 1.656 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.205766e-02 1.656 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.205766e-02 1.656 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.205766e-02 1.656 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.205766e-02 1.656 0 0
Nef and signal transduction R-HSA-164944 2.214514e-02 1.655 0 0
Integrin signaling R-HSA-354192 2.224567e-02 1.653 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.224567e-02 1.653 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.254219e-02 1.647 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.257207e-02 1.646 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.265507e-02 1.645 0 0
DARPP-32 events R-HSA-180024 2.265507e-02 1.645 0 0
HDMs demethylate histones R-HSA-3214842 2.280121e-02 1.642 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.414355e-02 1.617 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.487880e-02 1.604 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.487880e-02 1.604 0 0
Chromosome Maintenance R-HSA-73886 2.496330e-02 1.603 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.559564e-02 1.592 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.654433e-02 1.576 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.397028e-02 1.469 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.397028e-02 1.469 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.397028e-02 1.469 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.397028e-02 1.469 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.838249e-02 1.547 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.192574e-02 1.496 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.192574e-02 1.496 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.756191e-02 1.560 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.726578e-02 1.564 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.726578e-02 1.564 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.349680e-02 1.475 0 0
EGFR downregulation R-HSA-182971 3.252272e-02 1.488 0 0
Translation initiation complex formation R-HSA-72649 2.809740e-02 1.551 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.145324e-02 1.502 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.967921e-02 1.528 0 0
Signaling by FGFR3 R-HSA-5654741 2.728800e-02 1.564 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.149621e-02 1.502 0 0
Mitophagy R-HSA-5205647 3.134471e-02 1.504 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.804265e-02 1.552 0 0
Signaling by NOTCH R-HSA-157118 2.890020e-02 1.539 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.838249e-02 1.547 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.289698e-02 1.483 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.192574e-02 1.496 0 0
Regulated Necrosis R-HSA-5218859 2.993995e-02 1.524 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.857556e-02 1.544 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.828681e-02 1.548 0 0
Signaling by PTK6 R-HSA-8848021 2.828681e-02 1.548 0 0
Base Excision Repair R-HSA-73884 2.967921e-02 1.528 0 0
Interleukin-37 signaling R-HSA-9008059 2.726578e-02 1.564 0 0
Kinesins R-HSA-983189 3.410169e-02 1.467 0 0
RAB geranylgeranylation R-HSA-8873719 3.410169e-02 1.467 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.430109e-02 1.465 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.430109e-02 1.465 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.430109e-02 1.465 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.430109e-02 1.465 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.430109e-02 1.465 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.430109e-02 1.465 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.544283e-02 1.450 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.544851e-02 1.450 0 0
Opioid Signalling R-HSA-111885 3.544851e-02 1.450 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.574732e-02 1.447 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.574732e-02 1.447 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.574732e-02 1.447 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.574732e-02 1.447 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.574732e-02 1.447 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.574732e-02 1.447 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.574732e-02 1.447 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.637443e-02 1.439 0 0
Oncogene Induced Senescence R-HSA-2559585 3.678693e-02 1.434 0 0
Eukaryotic Translation Termination R-HSA-72764 3.721177e-02 1.429 0 0
mRNA Splicing R-HSA-72172 3.777184e-02 1.423 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.781383e-02 1.422 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.841732e-02 1.415 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.841732e-02 1.415 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.846653e-02 1.415 0 0
Centrosome maturation R-HSA-380287 3.919673e-02 1.407 0 0
Interleukin-1 family signaling R-HSA-446652 4.003845e-02 1.398 0 0
Toll-like Receptor Cascades R-HSA-168898 4.045912e-02 1.393 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.122778e-02 1.385 0 0
Selenocysteine synthesis R-HSA-2408557 4.169063e-02 1.380 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.181123e-02 1.379 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.222436e-02 1.374 0 0
Specification of primordial germ cells R-HSA-9827857 4.222436e-02 1.374 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 4.850728e-02 1.314 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.850728e-02 1.314 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.850728e-02 1.314 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.850728e-02 1.314 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.850728e-02 1.314 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 4.850728e-02 1.314 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 4.850728e-02 1.314 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 4.850728e-02 1.314 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.850728e-02 1.314 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.852712e-02 1.233 0 0
Axonal growth stimulation R-HSA-209563 5.852712e-02 1.233 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.339933e-02 1.272 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.339933e-02 1.272 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.339933e-02 1.272 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.339933e-02 1.272 0 0
Type I hemidesmosome assembly R-HSA-446107 4.579487e-02 1.339 0 0
RSK activation R-HSA-444257 4.579487e-02 1.339 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.579487e-02 1.339 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.046237e-02 1.297 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.046237e-02 1.297 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.046237e-02 1.297 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.213087e-02 1.283 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.732555e-02 1.325 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.839450e-02 1.234 0 0
G-protein beta:gamma signalling R-HSA-397795 4.513663e-02 1.345 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.513663e-02 1.345 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.551590e-02 1.256 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.256413e-02 1.279 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.256413e-02 1.279 0 0
MAP2K and MAPK activation R-HSA-5674135 5.353181e-02 1.271 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.353181e-02 1.271 0 0
Degradation of CDH1 R-HSA-9766229 4.696729e-02 1.328 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.692615e-02 1.245 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.036280e-02 1.298 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.707732e-02 1.244 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.513663e-02 1.345 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.626048e-02 1.250 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.626048e-02 1.250 0 0
Telomere Maintenance R-HSA-157579 4.479279e-02 1.349 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.626048e-02 1.250 0 0
Platelet calcium homeostasis R-HSA-418360 4.732555e-02 1.325 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.579487e-02 1.339 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.677455e-02 1.330 0 0
Activation of BH3-only proteins R-HSA-114452 5.551590e-02 1.256 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.630920e-02 1.334 0 0
Hedgehog 'off' state R-HSA-5610787 5.820840e-02 1.235 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.707732e-02 1.244 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.100171e-02 1.292 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.852712e-02 1.233 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.540580e-02 1.343 0 0
TRP channels R-HSA-3295583 5.839450e-02 1.234 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.933405e-02 1.307 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.339933e-02 1.272 0 0
Metabolism of RNA R-HSA-8953854 5.750651e-02 1.240 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.015925e-02 1.300 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.579487e-02 1.339 0 0
Formation of the nephric duct R-HSA-9830364 4.933405e-02 1.307 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.732555e-02 1.325 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.683528e-02 1.245 0 0
Maturation of protein E R-HSA-9694493 5.339933e-02 1.272 0 0
Maturation of protein E R-HSA-9683683 5.339933e-02 1.272 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.077768e-02 1.216 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.077768e-02 1.216 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.077768e-02 1.216 0 0
MTOR signalling R-HSA-165159 6.095873e-02 1.215 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.095873e-02 1.215 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.097314e-02 1.215 0 0
Notch-HLH transcription pathway R-HSA-350054 6.106128e-02 1.214 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.106128e-02 1.214 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.168498e-02 1.210 0 0
ALK mutants bind TKIs R-HSA-9700645 6.168498e-02 1.210 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.168498e-02 1.210 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.168498e-02 1.210 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.175954e-02 1.209 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.175954e-02 1.209 0 0
Signaling by EGFR R-HSA-177929 6.241950e-02 1.205 0 0
TNF signaling R-HSA-75893 6.241950e-02 1.205 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.241950e-02 1.205 0 0
Protein ubiquitination R-HSA-8852135 6.325609e-02 1.199 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.328803e-02 1.199 0 0
Regulation of signaling by CBL R-HSA-912631 6.328803e-02 1.199 0 0
The NLRP3 inflammasome R-HSA-844456 6.328803e-02 1.199 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.429264e-02 1.192 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.458051e-02 1.190 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.458051e-02 1.190 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.458051e-02 1.190 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.458051e-02 1.190 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.458051e-02 1.190 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.458051e-02 1.190 0 0
Budding and maturation of HIV virion R-HSA-162588 6.459802e-02 1.190 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.468846e-02 1.189 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.468846e-02 1.189 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.525035e-02 1.185 0 0
Cardiac conduction R-HSA-5576891 6.526204e-02 1.185 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.652142e-02 1.177 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.715252e-02 1.173 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.806104e-02 1.167 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.815268e-02 1.167 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.815268e-02 1.167 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.847621e-02 1.164 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.847621e-02 1.164 0 0
Interleukin-12 signaling R-HSA-9020591 6.954785e-02 1.158 0 0
Signalling to ERKs R-HSA-187687 6.979968e-02 1.156 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.979968e-02 1.156 0 0
Co-inhibition by PD-1 R-HSA-389948 7.000727e-02 1.155 0 0
Developmental Biology R-HSA-1266738 7.051112e-02 1.152 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.272905e-02 1.138 0 0
Viral mRNA Translation R-HSA-192823 7.426764e-02 1.129 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.500703e-02 1.125 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.500703e-02 1.125 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.589698e-02 1.120 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.589698e-02 1.120 0 0
Nephrin family interactions R-HSA-373753 7.589698e-02 1.120 0 0
Cellular response to chemical stress R-HSA-9711123 7.672815e-02 1.115 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.926577e-02 1.101 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.926577e-02 1.101 0 0
FLT3 signaling in disease R-HSA-9682385 7.964654e-02 1.099 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.031063e-02 1.095 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.031063e-02 1.095 0 0
Regulation of CDH11 function R-HSA-9762292 8.031063e-02 1.095 0 0
Josephin domain DUBs R-HSA-5689877 8.031063e-02 1.095 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.088249e-02 1.092 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.088249e-02 1.092 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.088249e-02 1.092 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.382376e-02 1.077 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.474769e-02 1.072 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.602972e-02 1.065 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.662961e-02 1.062 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.727665e-02 1.059 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.727665e-02 1.059 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.760699e-02 1.057 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 8.932940e-02 1.049 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 8.932940e-02 1.049 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.932940e-02 1.049 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 8.932940e-02 1.049 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.990908e-02 1.046 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.990908e-02 1.046 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.177240e-02 1.037 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.177240e-02 1.037 0 0
Signaling by NOTCH3 R-HSA-9012852 9.247063e-02 1.034 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.424459e-02 1.026 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.424459e-02 1.026 0 0
Mitochondrial transcription initiation R-HSA-163282 9.757369e-02 1.011 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 9.757369e-02 1.011 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 9.757369e-02 1.011 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 9.757369e-02 1.011 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 9.757369e-02 1.011 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.254607e-01 0.901 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.002662e-01 0.999 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.002662e-01 0.999 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.002662e-01 0.999 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.015903e-01 0.993 0 0
Signaling by APC mutants R-HSA-4839744 1.015903e-01 0.993 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.015903e-01 0.993 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.015903e-01 0.993 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.015903e-01 0.993 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.253738e-01 0.902 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.193079e-01 0.923 0 0
Translesion synthesis by REV1 R-HSA-110312 1.193079e-01 0.923 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.193079e-01 0.923 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.193079e-01 0.923 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.123903e-01 0.949 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.123903e-01 0.949 0 0
Translesion synthesis by POLI R-HSA-5656121 1.414393e-01 0.849 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.414393e-01 0.849 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.053136e-01 0.978 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.315275e-01 0.881 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.839250e-02 1.007 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.220809e-01 0.913 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.132269e-01 0.946 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.401632e-01 0.853 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.292248e-01 0.889 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.292248e-01 0.889 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.292248e-01 0.889 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.105366e-01 0.956 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.248413e-01 0.904 0 0
Ribosome-associated quality control R-HSA-9948299 1.099827e-01 0.959 0 0
Neutrophil degranulation R-HSA-6798695 1.123072e-01 0.950 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.924421e-02 1.003 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.368922e-01 0.864 0 0
Signaling by FGFR1 R-HSA-5654736 1.020911e-01 0.991 0 0
Prolonged ERK activation events R-HSA-169893 1.414393e-01 0.849 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.434780e-01 0.843 0 0
G1 Phase R-HSA-69236 1.300543e-01 0.886 0 0
Cyclin D associated events in G1 R-HSA-69231 1.300543e-01 0.886 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.356042e-01 0.868 0 0
Polo-like kinase mediated events R-HSA-156711 1.123903e-01 0.949 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.434780e-01 0.843 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.281050e-01 0.892 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.156968e-01 0.937 0 0
G0 and Early G1 R-HSA-1538133 1.345303e-01 0.871 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.839250e-02 1.007 0 0
Interleukin-1 signaling R-HSA-9020702 1.328122e-01 0.877 0 0
Signaling by WNT in cancer R-HSA-4791275 1.345303e-01 0.871 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.002662e-01 0.999 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.905406e-02 1.004 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.116101e-01 0.952 0 0
Host Interactions of HIV factors R-HSA-162909 1.360499e-01 0.866 0 0
DNA Replication R-HSA-69306 1.136391e-01 0.944 0 0
Adrenoceptors R-HSA-390696 1.289445e-01 0.890 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.123903e-01 0.949 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.384712e-01 0.859 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.413490e-01 0.850 0 0
HIV Infection R-HSA-162906 1.307977e-01 0.883 0 0
Signaling by SCF-KIT R-HSA-1433557 1.173658e-01 0.930 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.292248e-01 0.889 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.193079e-01 0.923 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.154262e-01 0.938 0 0
NrCAM interactions R-HSA-447038 1.254607e-01 0.901 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.253738e-01 0.902 0 0
Signaling by AXIN mutants R-HSA-4839735 1.253738e-01 0.902 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.351553e-01 0.869 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.254607e-01 0.901 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.289445e-01 0.890 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.050765e-01 0.978 0 0
Diseases of DNA repair R-HSA-9675135 9.742922e-02 1.011 0 0
Regulation of BACH1 activity R-HSA-9708530 1.414393e-01 0.849 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.282547e-01 0.892 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.201657e-01 0.920 0 0
Assembly Of The HIV Virion R-HSA-175474 1.053136e-01 0.978 0 0
Gene Silencing by RNA R-HSA-211000 1.073349e-01 0.969 0 0
Interleukin-12 family signaling R-HSA-447115 1.253398e-01 0.902 0 0
Regulation of beta-cell development R-HSA-186712 1.345076e-01 0.871 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.289445e-01 0.890 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.442067e-01 0.841 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.447924e-01 0.839 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.449490e-01 0.839 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.459639e-01 0.836 0 0
HIV elongation arrest and recovery R-HSA-167287 1.463473e-01 0.835 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.463473e-01 0.835 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.464112e-01 0.834 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.464792e-01 0.834 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.464792e-01 0.834 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.464792e-01 0.834 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.464792e-01 0.834 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.464792e-01 0.834 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.466731e-01 0.834 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.507883e-01 0.822 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.507883e-01 0.822 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.507883e-01 0.822 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.507883e-01 0.822 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.514541e-01 0.820 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.514541e-01 0.820 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.514541e-01 0.820 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.514541e-01 0.820 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.514541e-01 0.820 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.514541e-01 0.820 0 0
S Phase R-HSA-69242 1.522508e-01 0.817 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.539510e-01 0.813 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.539510e-01 0.813 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.553582e-01 0.809 0 0
Regulation of TP53 Expression R-HSA-6804754 1.553582e-01 0.809 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.553582e-01 0.809 0 0
C6 deamination of adenosine R-HSA-75102 1.553582e-01 0.809 0 0
Potassium transport channels R-HSA-1296067 1.553582e-01 0.809 0 0
Transcription from mitochondrial promoters R-HSA-75944 1.553582e-01 0.809 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.553582e-01 0.809 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.561528e-01 0.806 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.561528e-01 0.806 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.571405e-01 0.804 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.589435e-01 0.799 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.594961e-01 0.797 0 0
Deadenylation of mRNA R-HSA-429947 1.594961e-01 0.797 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.602855e-01 0.795 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.602855e-01 0.795 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.602855e-01 0.795 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.602855e-01 0.795 0 0
Defective SFTPA2 causes IPF R-HSA-5687868 1.602855e-01 0.795 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.605863e-01 0.794 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.605863e-01 0.794 0 0
Lipophagy R-HSA-9613354 1.605863e-01 0.794 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.605863e-01 0.794 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.645431e-01 0.784 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.645431e-01 0.784 0 0
Translesion synthesis by POLK R-HSA-5655862 1.653061e-01 0.782 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.653061e-01 0.782 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.658631e-01 0.780 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.658631e-01 0.780 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.658631e-01 0.780 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.658631e-01 0.780 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.658631e-01 0.780 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.663671e-01 0.779 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.679876e-01 0.775 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.679876e-01 0.775 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.721037e-01 0.764 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.721037e-01 0.764 0 0
Neurexins and neuroligins R-HSA-6794361 1.727027e-01 0.763 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.727027e-01 0.763 0 0
Glycolysis R-HSA-70171 1.729252e-01 0.762 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.742000e-01 0.759 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.742000e-01 0.759 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.742000e-01 0.759 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.787342e-01 0.748 0 0
TCR signaling R-HSA-202403 1.793086e-01 0.746 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.795800e-01 0.746 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.795800e-01 0.746 0 0
Frs2-mediated activation R-HSA-170968 1.795800e-01 0.746 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.836486e-01 0.736 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.837497e-01 0.736 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.844975e-01 0.734 0 0
Signaling by NOTCH2 R-HSA-1980145 1.860776e-01 0.730 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.860776e-01 0.730 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.860776e-01 0.730 0 0
Stabilization of p53 R-HSA-69541 1.873866e-01 0.727 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.875095e-01 0.727 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.907398e-01 0.720 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.907398e-01 0.720 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.907398e-01 0.720 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.922163e-01 0.716 0 0
Sensory processing of sound R-HSA-9659379 1.942144e-01 0.712 0 0
Signaling by ERBB4 R-HSA-1236394 1.961904e-01 0.707 0 0
Signaling by NOTCH4 R-HSA-9013694 1.961904e-01 0.707 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.975096e-01 0.704 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.975096e-01 0.704 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.975096e-01 0.704 0 0
Influenza Infection R-HSA-168255 1.979264e-01 0.703 0 0
IGF1R signaling cascade R-HSA-2428924 1.998524e-01 0.699 0 0
Vesicle-mediated transport R-HSA-5653656 2.031601e-01 0.692 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.948873e-01 0.530 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.948873e-01 0.530 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.948873e-01 0.530 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.948873e-01 0.530 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.948873e-01 0.530 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.948873e-01 0.530 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.948873e-01 0.530 0 0
MET activates PTPN11 R-HSA-8865999 2.178075e-01 0.662 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.819429e-01 0.550 0 0
HCN channels R-HSA-1296061 2.819429e-01 0.550 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.819429e-01 0.550 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.819429e-01 0.550 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.819429e-01 0.550 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.551792e-01 0.593 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.551792e-01 0.593 0 0
Disinhibition of SNARE formation R-HSA-114516 2.551792e-01 0.593 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.551792e-01 0.593 0 0
IRS activation R-HSA-74713 3.456203e-01 0.461 0 0
Activation of AKT2 R-HSA-165158 3.456203e-01 0.461 0 0
G2 Phase R-HSA-68911 3.456203e-01 0.461 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.094690e-01 0.679 0 0
cGMP effects R-HSA-418457 2.094690e-01 0.679 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.094690e-01 0.679 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.020980e-01 0.520 0 0
Regulation by c-FLIP R-HSA-3371378 3.020980e-01 0.520 0 0
Dimerization of procaspase-8 R-HSA-69416 3.020980e-01 0.520 0 0
Formation of annular gap junctions R-HSA-196025 3.020980e-01 0.520 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.020980e-01 0.520 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.020980e-01 0.520 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.683874e-01 0.571 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.683874e-01 0.571 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.408187e-01 0.618 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.175511e-01 0.662 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.455366e-01 0.610 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.733178e-01 0.563 0 0
Differentiation of T cells R-HSA-9945266 2.733178e-01 0.563 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.733178e-01 0.563 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.069293e-01 0.513 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.069293e-01 0.513 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.069293e-01 0.513 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.069293e-01 0.513 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.493671e-01 0.457 0 0
ARMS-mediated activation R-HSA-170984 3.493671e-01 0.457 0 0
Gap junction degradation R-HSA-190873 3.493671e-01 0.457 0 0
CASP8 activity is inhibited R-HSA-5218900 3.493671e-01 0.457 0 0
TRAIL signaling R-HSA-75158 4.073392e-01 0.390 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.073392e-01 0.390 0 0
PDE3B signalling R-HSA-165160 4.073392e-01 0.390 0 0
PKB-mediated events R-HSA-109703 4.073392e-01 0.390 0 0
Phosphorylation of Emi1 R-HSA-176417 4.073392e-01 0.390 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.073392e-01 0.390 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 4.073392e-01 0.390 0 0
Signaling by RNF43 mutants R-HSA-5340588 4.073392e-01 0.390 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 4.073392e-01 0.390 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.073392e-01 0.390 0 0
Signaling by MAPK mutants R-HSA-9652817 4.073392e-01 0.390 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.038948e-01 0.691 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.241427e-01 0.649 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.744840e-01 0.561 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.066552e-01 0.513 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.066552e-01 0.513 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.066552e-01 0.513 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.066552e-01 0.513 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.066552e-01 0.513 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.475658e-01 0.606 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.459753e-01 0.461 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.736735e-01 0.563 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.041775e-01 0.517 0 0
Formation of apoptosome R-HSA-111458 3.962707e-01 0.402 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.962707e-01 0.402 0 0
PI3K/AKT activation R-HSA-198203 3.962707e-01 0.402 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.962707e-01 0.402 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.962707e-01 0.402 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.962707e-01 0.402 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.962707e-01 0.402 0 0
Signaling by Erythropoietin R-HSA-9006335 2.717346e-01 0.566 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.717346e-01 0.566 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.717346e-01 0.566 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.450781e-01 0.611 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.405279e-01 0.468 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.006267e-01 0.522 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.006267e-01 0.522 0 0
TGFBR3 expression R-HSA-9839394 3.006267e-01 0.522 0 0
Tight junction interactions R-HSA-420029 3.006267e-01 0.522 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.188408e-01 0.660 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.965262e-01 0.528 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.344027e-01 0.476 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.344027e-01 0.476 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.850974e-01 0.414 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.850974e-01 0.414 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.380434e-01 0.623 0 0
Dual Incision in GG-NER R-HSA-5696400 2.921461e-01 0.534 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.144686e-01 0.669 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.876362e-01 0.541 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.218155e-01 0.492 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.156517e-01 0.501 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.740420e-01 0.562 0 0
HIV Transcription Elongation R-HSA-167169 3.096454e-01 0.509 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.096454e-01 0.509 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.096454e-01 0.509 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.096454e-01 0.509 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.474772e-01 0.459 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.395341e-01 0.469 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.956202e-01 0.403 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.733870e-01 0.428 0 0
Signaling by FGFR2 R-HSA-5654738 2.830535e-01 0.548 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.463132e-01 0.461 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.279202e-01 0.484 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.589523e-01 0.445 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.679412e-01 0.434 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.994239e-01 0.399 0 0
DNA Damage Bypass R-HSA-73893 2.981583e-01 0.526 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.320302e-01 0.479 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.830535e-01 0.548 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.470780e-01 0.460 0 0
G1/S Transition R-HSA-69206 3.290722e-01 0.483 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.938453e-01 0.532 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.486385e-01 0.604 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.966351e-01 0.528 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.041775e-01 0.517 0 0
Nucleotide Excision Repair R-HSA-5696398 3.935709e-01 0.405 0 0
mRNA Editing R-HSA-75072 3.493671e-01 0.457 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.050004e-01 0.688 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.094690e-01 0.679 0 0
Signal attenuation R-HSA-74749 3.962707e-01 0.402 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.876362e-01 0.541 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.493671e-01 0.457 0 0
Apoptotic factor-mediated response R-HSA-111471 3.746475e-01 0.426 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.066552e-01 0.513 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.259967e-01 0.487 0 0
Leukotriene receptors R-HSA-391906 2.094500e-01 0.679 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.819429e-01 0.550 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.405279e-01 0.468 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.994239e-01 0.399 0 0
Myogenesis R-HSA-525793 3.280964e-01 0.484 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.055823e-01 0.515 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.455366e-01 0.610 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.501762e-01 0.602 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.819429e-01 0.550 0 0
Dopamine receptors R-HSA-390651 2.819429e-01 0.550 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.551792e-01 0.593 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.456203e-01 0.461 0 0
Sodium/Calcium exchangers R-HSA-425561 2.683874e-01 0.571 0 0
PKA activation R-HSA-163615 2.175511e-01 0.662 0 0
mTORC1-mediated signalling R-HSA-166208 2.219578e-01 0.654 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.493671e-01 0.457 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.473974e-01 0.607 0 0
PTEN Regulation R-HSA-6807070 3.936064e-01 0.405 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.218155e-01 0.492 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.924395e-01 0.534 0 0
Cilium Assembly R-HSA-5617833 3.611036e-01 0.442 0 0
ERK/MAPK targets R-HSA-198753 3.041775e-01 0.517 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.994239e-01 0.399 0 0
Cellular response to starvation R-HSA-9711097 2.429168e-01 0.615 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.280964e-01 0.484 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.991770e-01 0.399 0 0
Ca2+ pathway R-HSA-4086398 3.453118e-01 0.462 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.459753e-01 0.461 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.779362e-01 0.556 0 0
GPVI-mediated activation cascade R-HSA-114604 3.395341e-01 0.469 0 0
Hedgehog 'on' state R-HSA-5632684 3.107522e-01 0.508 0 0
HIV Life Cycle R-HSA-162587 2.328890e-01 0.633 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.178075e-01 0.662 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.456203e-01 0.461 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.456203e-01 0.461 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.850974e-01 0.414 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.857404e-01 0.544 0 0
Signaling by Hedgehog R-HSA-5358351 2.485655e-01 0.605 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.490222e-01 0.457 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.466701e-01 0.608 0 0
Platelet degranulation R-HSA-114608 2.235869e-01 0.651 0 0
Neuronal System R-HSA-112316 2.490902e-01 0.604 0 0
Regulation of KIT signaling R-HSA-1433559 2.094690e-01 0.679 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.897262e-01 0.409 0 0
Transmission across Chemical Synapses R-HSA-112315 3.610799e-01 0.442 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.649504e-01 0.438 0 0
Signaling by LTK R-HSA-9842663 3.069293e-01 0.513 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.073392e-01 0.390 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.066552e-01 0.513 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.962707e-01 0.402 0 0
rRNA processing R-HSA-72312 4.021239e-01 0.396 0 0
Signaling by NOTCH1 R-HSA-1980143 2.236360e-01 0.650 0 0
Negative regulation of MET activity R-HSA-6807004 2.744840e-01 0.561 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.218155e-01 0.492 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.962707e-01 0.402 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.320302e-01 0.479 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.547866e-01 0.450 0 0
NGF-stimulated transcription R-HSA-9031628 2.785417e-01 0.555 0 0
Signaling by TGFBR3 R-HSA-9839373 3.463132e-01 0.461 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.890876e-01 0.410 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.921461e-01 0.534 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.066552e-01 0.513 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.466701e-01 0.608 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.522328e-01 0.598 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.717346e-01 0.566 0 0
Signaling by TGFB family members R-HSA-9006936 2.101950e-01 0.677 0 0
Signal regulatory protein family interactions R-HSA-391160 2.094690e-01 0.679 0 0
Co-stimulation by ICOS R-HSA-9927354 3.020980e-01 0.520 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.175511e-01 0.662 0 0
PKA activation in glucagon signalling R-HSA-164378 2.175511e-01 0.662 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.493671e-01 0.457 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.493671e-01 0.457 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 4.073392e-01 0.390 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.962707e-01 0.402 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.118493e-01 0.674 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.280964e-01 0.484 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.219578e-01 0.654 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.066698e-01 0.513 0 0
Interleukin-6 signaling R-HSA-1059683 3.459753e-01 0.461 0 0
Platelet sensitization by LDL R-HSA-432142 3.746475e-01 0.426 0 0
Heme signaling R-HSA-9707616 3.425816e-01 0.465 0 0
Smooth Muscle Contraction R-HSA-445355 2.740420e-01 0.562 0 0
Inflammasomes R-HSA-622312 2.475658e-01 0.606 0 0
Ion transport by P-type ATPases R-HSA-936837 3.805136e-01 0.420 0 0
Interleukin-1 processing R-HSA-448706 3.493671e-01 0.457 0 0
Glycogen storage diseases R-HSA-3229121 3.405279e-01 0.468 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.551792e-01 0.593 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.493671e-01 0.457 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.352980e-01 0.628 0 0
Stimuli-sensing channels R-HSA-2672351 2.805712e-01 0.552 0 0
Glucose metabolism R-HSA-70326 3.558777e-01 0.449 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.466701e-01 0.608 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.276448e-01 0.643 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.069293e-01 0.513 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.069293e-01 0.513 0 0
Maturation of nucleoprotein R-HSA-9683610 3.459753e-01 0.461 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.627962e-01 0.580 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.589523e-01 0.445 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.880249e-01 0.411 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.004866e-01 0.397 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.455366e-01 0.610 0 0
PKR-mediated signaling R-HSA-9833482 2.830535e-01 0.548 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.456203e-01 0.461 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.733178e-01 0.563 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 4.073392e-01 0.390 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.344027e-01 0.476 0 0
Signaling by Leptin R-HSA-2586552 3.962707e-01 0.402 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.408187e-01 0.618 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.969640e-01 0.401 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.179440e-01 0.498 0 0
Translation of Structural Proteins R-HSA-9683701 3.547062e-01 0.450 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 4.079195e-01 0.389 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 4.079195e-01 0.389 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 4.079195e-01 0.389 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 4.079195e-01 0.389 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 4.079195e-01 0.389 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 4.079195e-01 0.389 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 4.079195e-01 0.389 0 0
TRAF3 deficiency - HSE R-HSA-5602571 4.079195e-01 0.389 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 4.079195e-01 0.389 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 4.079195e-01 0.389 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 4.079195e-01 0.389 0 0
Intestinal infectious diseases R-HSA-8942233 4.079195e-01 0.389 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 4.079195e-01 0.389 0 0
XAV939 stabilizes AXIN R-HSA-5545619 4.079195e-01 0.389 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 4.079195e-01 0.389 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 4.079195e-01 0.389 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 4.079195e-01 0.389 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 4.079195e-01 0.389 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 4.079195e-01 0.389 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 4.079195e-01 0.389 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 4.079195e-01 0.389 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 4.079195e-01 0.389 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.079195e-01 0.389 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 4.079195e-01 0.389 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.079195e-01 0.389 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.083602e-01 0.389 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.087445e-01 0.389 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.087445e-01 0.389 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.087445e-01 0.389 0 0
Specification of the neural plate border R-HSA-9834899 4.087445e-01 0.389 0 0
Other interleukin signaling R-HSA-449836 4.087445e-01 0.389 0 0
Maturation of nucleoprotein R-HSA-9694631 4.087445e-01 0.389 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.124352e-01 0.385 0 0
Signaling by ALK R-HSA-201556 4.124352e-01 0.385 0 0
Ion channel transport R-HSA-983712 4.127208e-01 0.384 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.236457e-01 0.373 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.239126e-01 0.373 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.239126e-01 0.373 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.239126e-01 0.373 0 0
p38MAPK events R-HSA-171007 4.239126e-01 0.373 0 0
Protein methylation R-HSA-8876725 4.239126e-01 0.373 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.239126e-01 0.373 0 0
Formation of the anterior neural plate R-HSA-9823739 4.239126e-01 0.373 0 0
Nuclear import of Rev protein R-HSA-180746 4.254710e-01 0.371 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.254710e-01 0.371 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.254710e-01 0.371 0 0
HCMV Early Events R-HSA-9609690 4.282835e-01 0.368 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.301625e-01 0.366 0 0
Aquaporin-mediated transport R-HSA-445717 4.301625e-01 0.366 0 0
PI3K Cascade R-HSA-109704 4.334873e-01 0.363 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.342615e-01 0.362 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.368284e-01 0.360 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.368284e-01 0.360 0 0
Generation of second messenger molecules R-HSA-202433 4.368284e-01 0.360 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.368284e-01 0.360 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.368284e-01 0.360 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.368284e-01 0.360 0 0
Diseases of Immune System R-HSA-5260271 4.368284e-01 0.360 0 0
DAP12 signaling R-HSA-2424491 4.400265e-01 0.357 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.400265e-01 0.357 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.400265e-01 0.357 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.422168e-01 0.354 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.422168e-01 0.354 0 0
Interleukin-2 signaling R-HSA-9020558 4.422168e-01 0.354 0 0
Bicarbonate transporters R-HSA-425381 4.422168e-01 0.354 0 0
LGI-ADAM interactions R-HSA-5682910 4.422168e-01 0.354 0 0
Synthesis of PI R-HSA-1483226 4.422168e-01 0.354 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.422569e-01 0.354 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.425727e-01 0.354 0 0
Signal transduction by L1 R-HSA-445144 4.425727e-01 0.354 0 0
Formation of definitive endoderm R-HSA-9823730 4.425727e-01 0.354 0 0
Glycogen synthesis R-HSA-3322077 4.425727e-01 0.354 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.454680e-01 0.351 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.514171e-01 0.345 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.514171e-01 0.345 0 0
Regulation of Apoptosis R-HSA-169911 4.514171e-01 0.345 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.620863e-01 0.335 0 0
Phosphorylation of the APC/C R-HSA-176412 4.620863e-01 0.335 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.620863e-01 0.335 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.620863e-01 0.335 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.660916e-01 0.332 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.660916e-01 0.332 0 0
STAT5 Activation R-HSA-9645135 4.660916e-01 0.332 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 4.660916e-01 0.332 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.660916e-01 0.332 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.660916e-01 0.332 0 0
Abacavir transmembrane transport R-HSA-2161517 4.660916e-01 0.332 0 0
Neurofascin interactions R-HSA-447043 4.660916e-01 0.332 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.695634e-01 0.328 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.695634e-01 0.328 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.701063e-01 0.328 0 0
Signalling to RAS R-HSA-167044 4.759106e-01 0.322 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 4.759106e-01 0.322 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.765263e-01 0.322 0 0
Orc1 removal from chromatin R-HSA-68949 4.770577e-01 0.321 0 0
Triglyceride catabolism R-HSA-163560 4.771574e-01 0.321 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.852074e-01 0.314 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.865432e-01 0.313 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.865432e-01 0.313 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.867316e-01 0.313 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.867316e-01 0.313 0 0
Platelet homeostasis R-HSA-418346 4.954101e-01 0.305 0 0
IRE1alpha activates chaperones R-HSA-381070 4.978812e-01 0.303 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.993331e-01 0.302 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.993331e-01 0.302 0 0
Passive transport by Aquaporins R-HSA-432047 4.993331e-01 0.302 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.993331e-01 0.302 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.993331e-01 0.302 0 0
Disorders of Developmental Biology R-HSA-9675151 4.993331e-01 0.302 0 0
Degradation of AXIN R-HSA-4641257 5.025946e-01 0.299 0 0
Degradation of DVL R-HSA-4641258 5.025946e-01 0.299 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 5.028376e-01 0.299 0 0
Regulation of cortical dendrite branching R-HSA-8985801 5.028376e-01 0.299 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 5.028376e-01 0.299 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 5.028376e-01 0.299 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 5.028376e-01 0.299 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 5.028376e-01 0.299 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 5.028376e-01 0.299 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 5.028376e-01 0.299 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 5.028376e-01 0.299 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.028376e-01 0.299 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 5.028376e-01 0.299 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 5.028376e-01 0.299 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 5.028376e-01 0.299 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 5.028376e-01 0.299 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 5.028376e-01 0.299 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 5.028376e-01 0.299 0 0
Diseases of cellular response to stress R-HSA-9675132 5.028376e-01 0.299 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.028376e-01 0.299 0 0
DSCAM interactions R-HSA-376172 5.028376e-01 0.299 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 5.028376e-01 0.299 0 0
Integration of energy metabolism R-HSA-163685 5.048928e-01 0.297 0 0
Selenoamino acid metabolism R-HSA-2408522 5.092409e-01 0.293 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.144607e-01 0.289 0 0
Circadian clock R-HSA-9909396 5.149626e-01 0.288 0 0
Translation of Structural Proteins R-HSA-9694635 5.189820e-01 0.285 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.199407e-01 0.284 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.212427e-01 0.283 0 0
Netrin mediated repulsion signals R-HSA-418886 5.212427e-01 0.283 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.212427e-01 0.283 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.212427e-01 0.283 0 0
PTK6 Expression R-HSA-8849473 5.212427e-01 0.283 0 0
Recycling of eIF2:GDP R-HSA-72731 5.212427e-01 0.283 0 0
SOS-mediated signalling R-HSA-112412 5.212427e-01 0.283 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.212427e-01 0.283 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.212427e-01 0.283 0 0
Ca2+ activated K+ channels R-HSA-1296052 5.212427e-01 0.283 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 5.212427e-01 0.283 0 0
CHL1 interactions R-HSA-447041 5.212427e-01 0.283 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.212427e-01 0.283 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 5.212427e-01 0.283 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.212427e-01 0.283 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.217367e-01 0.283 0 0
Polymerase switching R-HSA-69091 5.294496e-01 0.276 0 0
Leading Strand Synthesis R-HSA-69109 5.294496e-01 0.276 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.294496e-01 0.276 0 0
Repression of WNT target genes R-HSA-4641265 5.294496e-01 0.276 0 0
Disorders of Nervous System Development R-HSA-9697154 5.294496e-01 0.276 0 0
Pervasive developmental disorders R-HSA-9005895 5.294496e-01 0.276 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.294496e-01 0.276 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.325017e-01 0.274 0 0
Regulation of insulin secretion R-HSA-422356 5.345681e-01 0.272 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.354163e-01 0.271 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.354163e-01 0.271 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.354163e-01 0.271 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.354163e-01 0.271 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.354163e-01 0.271 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.403630e-01 0.267 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.403630e-01 0.267 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.403630e-01 0.267 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.409839e-01 0.267 0 0
ER-Phagosome pathway R-HSA-1236974 5.440448e-01 0.264 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.446976e-01 0.264 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.446976e-01 0.264 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.446976e-01 0.264 0 0
Pyroptosis R-HSA-5620971 5.446976e-01 0.264 0 0
Amine ligand-binding receptors R-HSA-375280 5.555613e-01 0.255 0 0
Downstream TCR signaling R-HSA-202424 5.606910e-01 0.251 0 0
Transcription of the HIV genome R-HSA-167172 5.672469e-01 0.246 0 0
Signaling by FGFR in disease R-HSA-1226099 5.698515e-01 0.244 0 0
Formation of axial mesoderm R-HSA-9796292 5.701021e-01 0.244 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.701021e-01 0.244 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.701021e-01 0.244 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.701021e-01 0.244 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.701021e-01 0.244 0 0
Mismatch Repair R-HSA-5358508 5.701456e-01 0.244 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.701456e-01 0.244 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.701456e-01 0.244 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.701456e-01 0.244 0 0
Syndecan interactions R-HSA-3000170 5.711679e-01 0.243 0 0
Signaling by MET R-HSA-6806834 5.723589e-01 0.242 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.724373e-01 0.242 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.724373e-01 0.242 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.724373e-01 0.242 0 0
MET receptor recycling R-HSA-8875656 5.724373e-01 0.242 0 0
Activation of RAS in B cells R-HSA-1169092 5.724373e-01 0.242 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.724373e-01 0.242 0 0
Interleukin-9 signaling R-HSA-8985947 5.724373e-01 0.242 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.724373e-01 0.242 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.724373e-01 0.242 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 5.724373e-01 0.242 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.724373e-01 0.242 0 0
Interleukin-18 signaling R-HSA-9012546 5.724373e-01 0.242 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.726563e-01 0.242 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.762334e-01 0.239 0 0
Glycogen metabolism R-HSA-8982491 5.762334e-01 0.239 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.781455e-01 0.238 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.781455e-01 0.238 0 0
IRS-mediated signalling R-HSA-112399 5.820260e-01 0.235 0 0
PLC-gamma1 signalling R-HSA-167021 5.825437e-01 0.235 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.825437e-01 0.235 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.825437e-01 0.235 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.825437e-01 0.235 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.825437e-01 0.235 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.825437e-01 0.235 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 5.825437e-01 0.235 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.825437e-01 0.235 0 0
Phenylketonuria R-HSA-2160456 5.825437e-01 0.235 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.825437e-01 0.235 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 5.825437e-01 0.235 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.825437e-01 0.235 0 0
Invadopodia formation R-HSA-8941237 5.825437e-01 0.235 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.825437e-01 0.235 0 0
MET interacts with TNS proteins R-HSA-8875513 5.825437e-01 0.235 0 0
Histamine receptors R-HSA-390650 5.825437e-01 0.235 0 0
FasL/ CD95L signaling R-HSA-75157 5.825437e-01 0.235 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.865836e-01 0.232 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.877739e-01 0.231 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.877739e-01 0.231 0 0
PI Metabolism R-HSA-1483255 5.968670e-01 0.224 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.994352e-01 0.222 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.996466e-01 0.222 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.996466e-01 0.222 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.997398e-01 0.222 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.997398e-01 0.222 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.008622e-01 0.221 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.009868e-01 0.221 0 0
Dual incision in TC-NER R-HSA-6782135 6.019382e-01 0.220 0 0
Mitochondrial biogenesis R-HSA-1592230 6.020030e-01 0.220 0 0
Insulin receptor signalling cascade R-HSA-74751 6.030070e-01 0.220 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.033734e-01 0.219 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.033734e-01 0.219 0 0
Translesion Synthesis by POLH R-HSA-110320 6.033734e-01 0.219 0 0
MHC class II antigen presentation R-HSA-2132295 6.036642e-01 0.219 0 0
Prolactin receptor signaling R-HSA-1170546 6.085045e-01 0.216 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.085045e-01 0.216 0 0
Removal of the Flap Intermediate R-HSA-69166 6.085045e-01 0.216 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.085045e-01 0.216 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.085045e-01 0.216 0 0
Zinc transporters R-HSA-435354 6.085045e-01 0.216 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.085045e-01 0.216 0 0
HDL assembly R-HSA-8963896 6.085045e-01 0.216 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.132482e-01 0.212 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.195264e-01 0.208 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.195264e-01 0.208 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.195264e-01 0.208 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.195264e-01 0.208 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.195264e-01 0.208 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.195264e-01 0.208 0 0
Metabolism of non-coding RNA R-HSA-194441 6.213939e-01 0.207 0 0
snRNP Assembly R-HSA-191859 6.213939e-01 0.207 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.213939e-01 0.207 0 0
Cellular response to hypoxia R-HSA-1234174 6.216406e-01 0.206 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.216760e-01 0.206 0 0
Intra-Golgi traffic R-HSA-6811438 6.223938e-01 0.206 0 0
G1/S-Specific Transcription R-HSA-69205 6.237026e-01 0.205 0 0
RUNX2 regulates bone development R-HSA-8941326 6.237026e-01 0.205 0 0
Signaling by FGFR R-HSA-190236 6.257656e-01 0.204 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.258711e-01 0.204 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.258711e-01 0.204 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.258711e-01 0.204 0 0
Cargo concentration in the ER R-HSA-5694530 6.258711e-01 0.204 0 0
Downstream signal transduction R-HSA-186763 6.258711e-01 0.204 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.293542e-01 0.201 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.293542e-01 0.201 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.349921e-01 0.197 0 0
Protein hydroxylation R-HSA-9629569 6.349921e-01 0.197 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.389140e-01 0.195 0 0
PCP/CE pathway R-HSA-4086400 6.395099e-01 0.194 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.403483e-01 0.194 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.403604e-01 0.194 0 0
GPER1 signaling R-HSA-9634597 6.425332e-01 0.192 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.444279e-01 0.191 0 0
Erythropoietin activates RAS R-HSA-9027284 6.445443e-01 0.191 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.445443e-01 0.191 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.445443e-01 0.191 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.445443e-01 0.191 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.445443e-01 0.191 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.445443e-01 0.191 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.471315e-01 0.189 0 0
Voltage gated Potassium channels R-HSA-1296072 6.471315e-01 0.189 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.471315e-01 0.189 0 0
NADE modulates death signalling R-HSA-205025 6.494749e-01 0.187 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.494749e-01 0.187 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.494749e-01 0.187 0 0
Signaling by LRP5 mutants R-HSA-5339717 6.494749e-01 0.187 0 0
Defective MAT1A causes MATD R-HSA-5579024 6.494749e-01 0.187 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.494749e-01 0.187 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.494749e-01 0.187 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.494749e-01 0.187 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.494749e-01 0.187 0 0
Regulation of gap junction activity R-HSA-191650 6.494749e-01 0.187 0 0
Transmission across Electrical Synapses R-HSA-112307 6.494749e-01 0.187 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.494749e-01 0.187 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.494749e-01 0.187 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.494749e-01 0.187 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.494749e-01 0.187 0 0
Sensory perception of sour taste R-HSA-9729555 6.494749e-01 0.187 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.494749e-01 0.187 0 0
Interleukin-38 signaling R-HSA-9007892 6.494749e-01 0.187 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.565750e-01 0.183 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.565750e-01 0.183 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.565750e-01 0.183 0 0
Kidney development R-HSA-9830369 6.575542e-01 0.182 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.625106e-01 0.179 0 0
2-LTR circle formation R-HSA-164843 6.625106e-01 0.179 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.625106e-01 0.179 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.625106e-01 0.179 0 0
Binding and entry of HIV virion R-HSA-173107 6.625106e-01 0.179 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 6.625106e-01 0.179 0 0
Maturation of spike protein R-HSA-9683686 6.625106e-01 0.179 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.625106e-01 0.179 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.625106e-01 0.179 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.649289e-01 0.177 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.649289e-01 0.177 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.649289e-01 0.177 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.649289e-01 0.177 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.657103e-01 0.177 0 0
Hemostasis R-HSA-109582 6.674244e-01 0.176 0 0
MET promotes cell motility R-HSA-8875878 6.696791e-01 0.174 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.696791e-01 0.174 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.750469e-01 0.171 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.781691e-01 0.169 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.781691e-01 0.169 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.824764e-01 0.166 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.824764e-01 0.166 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.824764e-01 0.166 0 0
Insulin processing R-HSA-264876 6.824764e-01 0.166 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.843005e-01 0.165 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.843005e-01 0.165 0 0
Potassium Channels R-HSA-1296071 6.843005e-01 0.165 0 0
DAP12 interactions R-HSA-2172127 6.862098e-01 0.164 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.913125e-01 0.160 0 0
RAS processing R-HSA-9648002 6.913125e-01 0.160 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.931425e-01 0.159 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.931425e-01 0.159 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.931425e-01 0.159 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.931425e-01 0.159 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.980115e-01 0.156 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.980115e-01 0.156 0 0
HCMV Infection R-HSA-9609646 6.989329e-01 0.156 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.010709e-01 0.154 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.014955e-01 0.154 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.014955e-01 0.154 0 0
FGFR2b ligand binding and activation R-HSA-190377 7.014955e-01 0.154 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.014955e-01 0.154 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.014955e-01 0.154 0 0
Formation of the posterior neural plate R-HSA-9832991 7.014955e-01 0.154 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.014955e-01 0.154 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.014955e-01 0.154 0 0
Transport of RCbl within the body R-HSA-9758890 7.014955e-01 0.154 0 0
HCMV Late Events R-HSA-9610379 7.046092e-01 0.152 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 7.056782e-01 0.151 0 0
Activation of AMPA receptors R-HSA-399710 7.056782e-01 0.151 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 7.056782e-01 0.151 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 7.056782e-01 0.151 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.056782e-01 0.151 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 7.056782e-01 0.151 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 7.056782e-01 0.151 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 7.056782e-01 0.151 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.056782e-01 0.151 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 7.056782e-01 0.151 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 7.056782e-01 0.151 0 0
Muscarinic acetylcholine receptors R-HSA-390648 7.056782e-01 0.151 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 7.056782e-01 0.151 0 0
Reelin signalling pathway R-HSA-8866376 7.056782e-01 0.151 0 0
Co-inhibition by BTLA R-HSA-9927353 7.056782e-01 0.151 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.059032e-01 0.151 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.059032e-01 0.151 0 0
Telomere Extension By Telomerase R-HSA-171319 7.070287e-01 0.151 0 0
COPII-mediated vesicle transport R-HSA-204005 7.077051e-01 0.150 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.093752e-01 0.149 0 0
Phase 2 - plateau phase R-HSA-5576893 7.093752e-01 0.149 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.093752e-01 0.149 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.093752e-01 0.149 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.120085e-01 0.148 0 0
Interleukin-2 family signaling R-HSA-451927 7.120085e-01 0.148 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.191630e-01 0.143 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.196182e-01 0.143 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.196182e-01 0.143 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.196182e-01 0.143 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.196182e-01 0.143 0 0
Signaling by KIT in disease R-HSA-9669938 7.196182e-01 0.143 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.198622e-01 0.143 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.198622e-01 0.143 0 0
Adaptive Immune System R-HSA-1280218 7.227929e-01 0.141 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.247738e-01 0.140 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.247738e-01 0.140 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.247738e-01 0.140 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.317527e-01 0.136 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.317527e-01 0.136 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 7.366585e-01 0.133 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.366585e-01 0.133 0 0
ERKs are inactivated R-HSA-202670 7.366585e-01 0.133 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.366585e-01 0.133 0 0
Integration of provirus R-HSA-162592 7.366585e-01 0.133 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.366585e-01 0.133 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 7.366585e-01 0.133 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 7.366585e-01 0.133 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.366585e-01 0.133 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.366585e-01 0.133 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.366585e-01 0.133 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.381987e-01 0.132 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.381987e-01 0.132 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.381987e-01 0.132 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.381987e-01 0.132 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.405894e-01 0.130 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.443645e-01 0.128 0 0
Growth hormone receptor signaling R-HSA-982772 7.443645e-01 0.128 0 0
Inositol phosphate metabolism R-HSA-1483249 7.462880e-01 0.127 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.505385e-01 0.125 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.512852e-01 0.124 0 0
Activation of the pre-replicative complex R-HSA-68962 7.520494e-01 0.124 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.520494e-01 0.124 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.528725e-01 0.123 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.528725e-01 0.123 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.528725e-01 0.123 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.528725e-01 0.123 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.528725e-01 0.123 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.528725e-01 0.123 0 0
Formation of the Editosome R-HSA-75094 7.528725e-01 0.123 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.528725e-01 0.123 0 0
Synthesis of PS R-HSA-1483101 7.528725e-01 0.123 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.528725e-01 0.123 0 0
Ceramide signalling R-HSA-193681 7.528725e-01 0.123 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.528725e-01 0.123 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.528725e-01 0.123 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 7.528725e-01 0.123 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.528725e-01 0.123 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.528725e-01 0.123 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.528725e-01 0.123 0 0
Metal ion SLC transporters R-HSA-425410 7.600129e-01 0.119 0 0
Synthesis of DNA R-HSA-69239 7.601133e-01 0.119 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.601937e-01 0.119 0 0
RNA Polymerase III Transcription R-HSA-74158 7.601937e-01 0.119 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.602565e-01 0.119 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.642843e-01 0.117 0 0
GAB1 signalosome R-HSA-180292 7.647060e-01 0.117 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.647060e-01 0.117 0 0
Tie2 Signaling R-HSA-210993 7.647060e-01 0.117 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.674085e-01 0.115 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.674085e-01 0.115 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.674085e-01 0.115 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.674085e-01 0.115 0 0
Interleukin-6 family signaling R-HSA-6783589 7.674085e-01 0.115 0 0
Regulation of IFNG signaling R-HSA-877312 7.682227e-01 0.115 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.682227e-01 0.115 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.682227e-01 0.115 0 0
Interleukin-15 signaling R-HSA-8983432 7.682227e-01 0.115 0 0
Estrogen biosynthesis R-HSA-193144 7.682227e-01 0.115 0 0
OAS antiviral response R-HSA-8983711 7.682227e-01 0.115 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.683668e-01 0.114 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.715864e-01 0.113 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.719746e-01 0.112 0 0
Gap junction trafficking and regulation R-HSA-157858 7.763787e-01 0.110 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.806021e-01 0.108 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.887934e-01 0.103 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.887934e-01 0.103 0 0
Interleukin-7 signaling R-HSA-1266695 7.887934e-01 0.103 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.925015e-01 0.101 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.925015e-01 0.101 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.925015e-01 0.101 0 0
Hydrolysis of LPE R-HSA-1483152 7.925015e-01 0.101 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.925015e-01 0.101 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.925015e-01 0.101 0 0
NADPH regeneration R-HSA-389542 7.925015e-01 0.101 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.925015e-01 0.101 0 0
Lipid particle organization R-HSA-8964572 7.925015e-01 0.101 0 0
HDL clearance R-HSA-8964011 7.925015e-01 0.101 0 0
Acetylcholine binding and downstream events R-HSA-181431 7.964379e-01 0.099 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 7.964379e-01 0.099 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.964379e-01 0.099 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.964379e-01 0.099 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.964379e-01 0.099 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.964379e-01 0.099 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.964379e-01 0.099 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.964379e-01 0.099 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.964379e-01 0.099 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.964379e-01 0.099 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.964379e-01 0.099 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.964379e-01 0.099 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.964379e-01 0.099 0 0
Gap junction trafficking R-HSA-190828 8.011854e-01 0.096 0 0
Gastrulation R-HSA-9758941 8.059096e-01 0.094 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.066337e-01 0.093 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.085743e-01 0.092 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.095753e-01 0.092 0 0
Nuclear RNA decay R-HSA-9930044 8.095753e-01 0.092 0 0
Cardiogenesis R-HSA-9733709 8.095753e-01 0.092 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.111469e-01 0.091 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.111469e-01 0.091 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.111469e-01 0.091 0 0
Creatine metabolism R-HSA-71288 8.111469e-01 0.091 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.111469e-01 0.091 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.111469e-01 0.091 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.123997e-01 0.090 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.162065e-01 0.088 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.162065e-01 0.088 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.215665e-01 0.085 0 0
Malate-aspartate shuttle R-HSA-9856872 8.215665e-01 0.085 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.215665e-01 0.085 0 0
Extension of Telomeres R-HSA-180786 8.251689e-01 0.083 0 0
Triglyceride metabolism R-HSA-8979227 8.251689e-01 0.083 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.257775e-01 0.083 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.257775e-01 0.083 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 8.257775e-01 0.083 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 8.257775e-01 0.083 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.257775e-01 0.083 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.257775e-01 0.083 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 8.257775e-01 0.083 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.257775e-01 0.083 0 0
DAG1 core M1 glycosylations R-HSA-8932506 8.257775e-01 0.083 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.257775e-01 0.083 0 0
mRNA Editing: C to U Conversion R-HSA-72200 8.257775e-01 0.083 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.257775e-01 0.083 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 8.257775e-01 0.083 0 0
Glycoprotein hormones R-HSA-209822 8.257775e-01 0.083 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.257775e-01 0.083 0 0
Maturation of replicase proteins R-HSA-9694301 8.257775e-01 0.083 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.262073e-01 0.083 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.262073e-01 0.083 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.262073e-01 0.083 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.268161e-01 0.083 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.268161e-01 0.083 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.287332e-01 0.082 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.287834e-01 0.082 0 0
Lagging Strand Synthesis R-HSA-69186 8.313043e-01 0.080 0 0
Basigin interactions R-HSA-210991 8.313043e-01 0.080 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.336761e-01 0.079 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.340156e-01 0.079 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.346878e-01 0.078 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.374274e-01 0.077 0 0
Maturation of spike protein R-HSA-9694548 8.419440e-01 0.075 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.419440e-01 0.075 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.435820e-01 0.074 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.435907e-01 0.074 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.435907e-01 0.074 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.435907e-01 0.074 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.438726e-01 0.074 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.438726e-01 0.074 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.438726e-01 0.074 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.438726e-01 0.074 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.438726e-01 0.074 0 0
Adipogenesis R-HSA-9843745 8.485701e-01 0.071 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.490043e-01 0.071 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.495834e-01 0.071 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.537187e-01 0.069 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.537187e-01 0.069 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.537187e-01 0.069 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.537187e-01 0.069 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.537187e-01 0.069 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.537187e-01 0.069 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.537187e-01 0.069 0 0
Nucleotide salvage defects R-HSA-9734207 8.537187e-01 0.069 0 0
Alpha-defensins R-HSA-1462054 8.537187e-01 0.069 0 0
Sodium/Proton exchangers R-HSA-425986 8.537187e-01 0.069 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.552378e-01 0.068 0 0
Activation of SMO R-HSA-5635838 8.636151e-01 0.064 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.636151e-01 0.064 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.636151e-01 0.064 0 0
Killing mechanisms R-HSA-9664420 8.636151e-01 0.064 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.636151e-01 0.064 0 0
Interferon Signaling R-HSA-913531 8.640107e-01 0.063 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.661118e-01 0.062 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.661118e-01 0.062 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.661118e-01 0.062 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.675871e-01 0.062 0 0
Immune System R-HSA-168256 8.680056e-01 0.061 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.685057e-01 0.061 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.701915e-01 0.060 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.730473e-01 0.059 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.746370e-01 0.058 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.771802e-01 0.057 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.771802e-01 0.057 0 0
Calcineurin activates NFAT R-HSA-2025928 8.771802e-01 0.057 0 0
Unwinding of DNA R-HSA-176974 8.771802e-01 0.057 0 0
WNT mediated activation of DVL R-HSA-201688 8.771802e-01 0.057 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.771802e-01 0.057 0 0
Interleukin-21 signaling R-HSA-9020958 8.771802e-01 0.057 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.771802e-01 0.057 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.771802e-01 0.057 0 0
Degradation of GABA R-HSA-916853 8.771802e-01 0.057 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.771802e-01 0.057 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.771802e-01 0.057 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.771802e-01 0.057 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.771802e-01 0.057 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.771802e-01 0.057 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.784040e-01 0.056 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.790676e-01 0.056 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.810425e-01 0.055 0 0
Synthesis of PG R-HSA-1483148 8.810425e-01 0.055 0 0
G alpha (s) signalling events R-HSA-418555 8.812197e-01 0.055 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.858900e-01 0.053 0 0
Surfactant metabolism R-HSA-5683826 8.896889e-01 0.051 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.900045e-01 0.051 0 0
Complex III assembly R-HSA-9865881 8.944263e-01 0.048 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.944263e-01 0.048 0 0
Viral Infection Pathways R-HSA-9824446 8.952662e-01 0.048 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.963894e-01 0.048 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.963894e-01 0.048 0 0
DNA replication initiation R-HSA-68952 8.968799e-01 0.047 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.968799e-01 0.047 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.968799e-01 0.047 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.968799e-01 0.047 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.968799e-01 0.047 0 0
Arachidonate production from DAG R-HSA-426048 8.968799e-01 0.047 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.968799e-01 0.047 0 0
Interleukin-27 signaling R-HSA-9020956 8.968799e-01 0.047 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.968799e-01 0.047 0 0
Sperm Motility And Taxes R-HSA-1300642 8.968799e-01 0.047 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.968799e-01 0.047 0 0
Peptide hormone biosynthesis R-HSA-209952 8.968799e-01 0.047 0 0
Serotonin receptors R-HSA-390666 8.968799e-01 0.047 0 0
Peroxisomal protein import R-HSA-9033241 8.972321e-01 0.047 0 0
DNA strand elongation R-HSA-69190 8.975836e-01 0.047 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.975836e-01 0.047 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.976392e-01 0.047 0 0
Leishmania infection R-HSA-9658195 8.996644e-01 0.046 0 0
Parasitic Infection Pathways R-HSA-9824443 8.996644e-01 0.046 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.027146e-01 0.044 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.064610e-01 0.043 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.085639e-01 0.042 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.098747e-01 0.041 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.098747e-01 0.041 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.098747e-01 0.041 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.098747e-01 0.041 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.098747e-01 0.041 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.098747e-01 0.041 0 0
Nephron development R-HSA-9831926 9.098747e-01 0.041 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 9.098747e-01 0.041 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.121094e-01 0.040 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.121094e-01 0.040 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.127640e-01 0.040 0 0
DAG1 core M3 glycosylations R-HSA-8932505 9.134207e-01 0.039 0 0
vRNP Assembly R-HSA-192905 9.134207e-01 0.039 0 0
vRNA Synthesis R-HSA-192814 9.134207e-01 0.039 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.134207e-01 0.039 0 0
Conjugation of benzoate with glycine R-HSA-177135 9.134207e-01 0.039 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 9.134207e-01 0.039 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 9.134207e-01 0.039 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 9.134207e-01 0.039 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 9.134207e-01 0.039 0 0
Suppression of apoptosis R-HSA-9635465 9.134207e-01 0.039 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.134207e-01 0.039 0 0
ABC-family proteins mediated transport R-HSA-382556 9.162208e-01 0.038 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.172389e-01 0.038 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.172389e-01 0.038 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.177619e-01 0.037 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.178417e-01 0.037 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.178417e-01 0.037 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.196004e-01 0.036 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.217007e-01 0.035 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.217007e-01 0.035 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.217007e-01 0.035 0 0
Intraflagellar transport R-HSA-5620924 9.245763e-01 0.034 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.265597e-01 0.033 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.265597e-01 0.033 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.265597e-01 0.033 0 0
Gap junction assembly R-HSA-190861 9.265597e-01 0.033 0 0
SARS-CoV Infections R-HSA-9679506 9.267125e-01 0.033 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.268718e-01 0.033 0 0
Cristae formation R-HSA-8949613 9.268718e-01 0.033 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 9.273092e-01 0.033 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.273092e-01 0.033 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.273092e-01 0.033 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.273092e-01 0.033 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.288770e-01 0.032 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.298119e-01 0.032 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.320526e-01 0.031 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.320526e-01 0.031 0 0
Signaling by NODAL R-HSA-1181150 9.320526e-01 0.031 0 0
PERK regulates gene expression R-HSA-381042 9.344348e-01 0.029 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.356737e-01 0.029 0 0
Innate Immune System R-HSA-168249 9.372578e-01 0.028 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.389704e-01 0.027 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.389704e-01 0.027 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.389704e-01 0.027 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.389704e-01 0.027 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.389704e-01 0.027 0 0
Interleukin-35 Signalling R-HSA-8984722 9.389704e-01 0.027 0 0
MET activates RAS signaling R-HSA-8851805 9.389704e-01 0.027 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.389704e-01 0.027 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.389704e-01 0.027 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.389704e-01 0.027 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.389704e-01 0.027 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.410442e-01 0.026 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.410442e-01 0.026 0 0
Signaling by Insulin receptor R-HSA-74752 9.410615e-01 0.026 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.410990e-01 0.026 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.410990e-01 0.026 0 0
Phenylalanine metabolism R-HSA-8964208 9.410990e-01 0.026 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.410990e-01 0.026 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.410990e-01 0.026 0 0
RSV-host interactions R-HSA-9833110 9.413491e-01 0.026 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.415360e-01 0.026 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.415360e-01 0.026 0 0
mRNA Capping R-HSA-72086 9.431166e-01 0.025 0 0
GPCR downstream signalling R-HSA-388396 9.475355e-01 0.023 0 0
Proteasome assembly R-HSA-9907900 9.480620e-01 0.023 0 0
Processing of SMDT1 R-HSA-8949664 9.487615e-01 0.023 0 0
Chylomicron remodeling R-HSA-8963901 9.487615e-01 0.023 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.487615e-01 0.023 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.487615e-01 0.023 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.487615e-01 0.023 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.487615e-01 0.023 0 0
Ribavirin ADME R-HSA-9755088 9.489923e-01 0.023 0 0
Somitogenesis R-HSA-9824272 9.534072e-01 0.021 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.558437e-01 0.020 0 0
FGFR2 alternative splicing R-HSA-6803529 9.558695e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.558695e-01 0.020 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.569822e-01 0.019 0 0
Hydrolysis of LPC R-HSA-1483115 9.569822e-01 0.019 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.569822e-01 0.019 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.569822e-01 0.019 0 0
Physiological factors R-HSA-5578768 9.569822e-01 0.019 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.569822e-01 0.019 0 0
Ciprofloxacin ADME R-HSA-9793528 9.569822e-01 0.019 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.582463e-01 0.019 0 0
Pentose phosphate pathway R-HSA-71336 9.588303e-01 0.018 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.588303e-01 0.018 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.599774e-01 0.018 0 0
Signaling by PDGF R-HSA-186797 9.599774e-01 0.018 0 0
tRNA processing in the nucleus R-HSA-6784531 9.599774e-01 0.018 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.613054e-01 0.017 0 0
Interferon gamma signaling R-HSA-877300 9.616939e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.618535e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.618535e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.618535e-01 0.017 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.618535e-01 0.017 0 0
Biosynthesis of maresins R-HSA-9018682 9.618535e-01 0.017 0 0
Carnitine shuttle R-HSA-200425 9.618535e-01 0.017 0 0
Interleukin-20 family signaling R-HSA-8854691 9.618535e-01 0.017 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.618535e-01 0.017 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.618535e-01 0.017 0 0
G alpha (z) signalling events R-HSA-418597 9.628621e-01 0.016 0 0
G alpha (q) signalling events R-HSA-416476 9.631283e-01 0.016 0 0
Integrin cell surface interactions R-HSA-216083 9.633620e-01 0.016 0 0
ABC transporter disorders R-HSA-5619084 9.633620e-01 0.016 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.634507e-01 0.016 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.638844e-01 0.016 0 0
Protein lipoylation R-HSA-9857492 9.638844e-01 0.016 0 0
Biotin transport and metabolism R-HSA-196780 9.638844e-01 0.016 0 0
Protein repair R-HSA-5676934 9.638844e-01 0.016 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.638844e-01 0.016 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.638844e-01 0.016 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.638844e-01 0.016 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.638844e-01 0.016 0 0
Other semaphorin interactions R-HSA-416700 9.638844e-01 0.016 0 0
DNA Damage Reversal R-HSA-73942 9.638844e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.670537e-01 0.015 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.670537e-01 0.015 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.692080e-01 0.014 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.696795e-01 0.013 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.696795e-01 0.013 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.696795e-01 0.013 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.696795e-01 0.013 0 0
Fructose catabolism R-HSA-70350 9.696795e-01 0.013 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.696795e-01 0.013 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.696795e-01 0.013 0 0
Atorvastatin ADME R-HSA-9754706 9.696795e-01 0.013 0 0
Heme degradation R-HSA-189483 9.702233e-01 0.013 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.712800e-01 0.013 0 0
HIV Transcription Initiation R-HSA-167161 9.712800e-01 0.013 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.712800e-01 0.013 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.712800e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.715677e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.715677e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.715677e-01 0.013 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.715677e-01 0.013 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.715677e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.715677e-01 0.013 0 0
Potential therapeutics for SARS R-HSA-9679191 9.721560e-01 0.012 0 0
Developmental Cell Lineages R-HSA-9734767 9.726780e-01 0.012 0 0
eNOS activation R-HSA-203615 9.739157e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.739157e-01 0.011 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.745449e-01 0.011 0 0
Glycine degradation R-HSA-6783984 9.745449e-01 0.011 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.745449e-01 0.011 0 0
Fibronectin matrix formation R-HSA-1566977 9.745449e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.754816e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.754816e-01 0.011 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.754816e-01 0.011 0 0
The phototransduction cascade R-HSA-2514856 9.762230e-01 0.010 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.771704e-01 0.010 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.775171e-01 0.010 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.786299e-01 0.009 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.786299e-01 0.009 0 0
Catecholamine biosynthesis R-HSA-209905 9.786299e-01 0.009 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.786299e-01 0.009 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.786299e-01 0.009 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.788719e-01 0.009 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.788719e-01 0.009 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.800361e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.800361e-01 0.009 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.811389e-01 0.008 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.818057e-01 0.008 0 0
Pyrimidine salvage R-HSA-73614 9.818057e-01 0.008 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.820595e-01 0.008 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.820595e-01 0.008 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.820595e-01 0.008 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.820595e-01 0.008 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.823458e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.824617e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.825547e-01 0.008 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.825563e-01 0.008 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.832883e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.843422e-01 0.007 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.847704e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.847990e-01 0.007 0 0
Pyrimidine biosynthesis R-HSA-500753 9.849389e-01 0.007 0 0
Conjugation of carboxylic acids R-HSA-159424 9.849389e-01 0.007 0 0
Amino Acid conjugation R-HSA-156587 9.849389e-01 0.007 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.849389e-01 0.007 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.849389e-01 0.007 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.849389e-01 0.007 0 0
Paracetamol ADME R-HSA-9753281 9.850886e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.856360e-01 0.006 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.858642e-01 0.006 0 0
Mitochondrial protein degradation R-HSA-9837999 9.861826e-01 0.006 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.863641e-01 0.006 0 0
Neurotransmitter clearance R-HSA-112311 9.865334e-01 0.006 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.867136e-01 0.006 0 0
Parasite infection R-HSA-9664407 9.871247e-01 0.006 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.871247e-01 0.006 0 0
Leishmania phagocytosis R-HSA-9664417 9.871247e-01 0.006 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.873562e-01 0.006 0 0
Pregnenolone biosynthesis R-HSA-196108 9.873562e-01 0.006 0 0
Gluconeogenesis R-HSA-70263 9.879906e-01 0.005 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.884173e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.884173e-01 0.005 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.884247e-01 0.005 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.888762e-01 0.005 0 0
G-protein activation R-HSA-202040 9.893857e-01 0.005 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.893857e-01 0.005 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.893857e-01 0.005 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.896860e-01 0.005 0 0
DAG1 glycosylations R-HSA-8931838 9.900559e-01 0.004 0 0
Azathioprine ADME R-HSA-9748787 9.907056e-01 0.004 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.907671e-01 0.004 0 0
Serine metabolism R-HSA-977347 9.910896e-01 0.004 0 0
Glutathione synthesis and recycling R-HSA-174403 9.910896e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.914373e-01 0.004 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.914619e-01 0.004 0 0
Recycling of bile acids and salts R-HSA-159418 9.914619e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.918249e-01 0.004 0 0
tRNA Aminoacylation R-HSA-379724 9.918249e-01 0.004 0 0
Protein folding R-HSA-391251 9.922902e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.923921e-01 0.003 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.925200e-01 0.003 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.925200e-01 0.003 0 0
LDL clearance R-HSA-8964038 9.925200e-01 0.003 0 0
Fructose metabolism R-HSA-5652084 9.925200e-01 0.003 0 0
Ethanol oxidation R-HSA-71384 9.925200e-01 0.003 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.925200e-01 0.003 0 0
Protein localization R-HSA-9609507 9.925250e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.927666e-01 0.003 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.932561e-01 0.003 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.937150e-01 0.003 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.937208e-01 0.003 0 0
Formation of the ureteric bud R-HSA-9830674 9.937208e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.937653e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.938490e-01 0.003 0 0
Translation R-HSA-72766 9.940450e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.942266e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.942266e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.944272e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.944583e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.946115e-01 0.002 0 0
Signaling by GPCR R-HSA-372790 9.946300e-01 0.002 0 0
CYP2E1 reactions R-HSA-211999 9.947290e-01 0.002 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.947290e-01 0.002 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.947290e-01 0.002 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.947290e-01 0.002 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.947290e-01 0.002 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.950774e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.955661e-01 0.002 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.955753e-01 0.002 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.955753e-01 0.002 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.955753e-01 0.002 0 0
Fertilization R-HSA-1187000 9.955753e-01 0.002 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.955753e-01 0.002 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.955753e-01 0.002 0 0
Laminin interactions R-HSA-3000157 9.955753e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.958036e-01 0.002 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.960444e-01 0.002 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.960444e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.960444e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.960444e-01 0.002 0 0
MET activates PTK2 signaling R-HSA-8874081 9.962857e-01 0.002 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.962857e-01 0.002 0 0
Urea cycle R-HSA-70635 9.962857e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.966130e-01 0.001 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.968822e-01 0.001 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.968822e-01 0.001 0 0
Triglyceride biosynthesis R-HSA-75109 9.968822e-01 0.001 0 0
Synthesis of PE R-HSA-1483213 9.968822e-01 0.001 0 0
Signaling by BMP R-HSA-201451 9.968822e-01 0.001 0 0
Neddylation R-HSA-8951664 9.970459e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.971648e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.973028e-01 0.001 0 0
Prednisone ADME R-HSA-9757110 9.973828e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.974609e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.975824e-01 0.001 0 0
Thyroxine biosynthesis R-HSA-209968 9.978032e-01 0.001 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.978032e-01 0.001 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.978032e-01 0.001 0 0
Glucagon-type ligand receptors R-HSA-420092 9.978032e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.978788e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.979459e-01 0.001 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.981560e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.984096e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.984500e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.984500e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.984522e-01 0.001 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.984522e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.987781e-01 0.001 0 0
Methylation R-HSA-156581 9.988690e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.989741e-01 0.000 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.990847e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991143e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.991143e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.991718e-01 0.000 0 0
Signal amplification R-HSA-392518 9.992317e-01 0.000 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.992317e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.992789e-01 0.000 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.993551e-01 0.000 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.993551e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.994245e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.994245e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.994315e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995099e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.995457e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996105e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.996105e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.996187e-01 0.000 0 0
Purine salvage R-HSA-74217 9.996187e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.996187e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.996194e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.996800e-01 0.000 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.996800e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.997090e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.997314e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.997534e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.997542e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.997705e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997979e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997981e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998004e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998004e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.998108e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.998108e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.998412e-01 0.000 0 0
tRNA processing R-HSA-72306 9.998489e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.998625e-01 0.000 0 0
Defensins R-HSA-1461973 9.998667e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998732e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.998897e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998911e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998911e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998911e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998990e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999057e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999114e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.999126e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999197e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999310e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.999339e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.999339e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.999445e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999462e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.999534e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.999609e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.999672e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999680e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999694e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999720e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999729e-01 0.000 0 0
Disease R-HSA-1643685 9.999729e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999765e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999774e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999828e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999829e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999852e-01 0.000 0 0
Digestion R-HSA-8935690 9.999864e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999873e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999876e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999886e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999906e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999911e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999919e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999932e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999943e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999950e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999952e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999960e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999966e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999966e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999966e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999972e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999972e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999976e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999980e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999983e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999983e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999986e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999988e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999989e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999990e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999992e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999995e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999996e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999997e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999997e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999998e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell-Cell communication R-HSA-1500931 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 5.551115e-16 15.256 0 0
Cell Cycle Checkpoints R-HSA-69620 6.994405e-15 14.155 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.762857e-14 13.322 0 0
Apoptotic execution phase R-HSA-75153 1.189049e-13 12.925 0 0
Apoptosis R-HSA-109581 1.373346e-13 12.862 0 0
Signaling by ROBO receptors R-HSA-376176 1.656453e-13 12.781 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.793321e-13 12.554 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.793321e-13 12.554 0 0
Cell junction organization R-HSA-446728 3.151923e-13 12.501 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.337641e-13 12.363 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.209788e-13 12.142 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.209788e-13 12.142 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.479372e-12 11.830 0 0
Adherens junctions interactions R-HSA-418990 1.679323e-12 11.775 0 0
G2/M Checkpoints R-HSA-69481 1.885381e-12 11.725 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.036704e-12 11.691 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.609246e-12 11.583 0 0
Programmed Cell Death R-HSA-5357801 5.860645e-12 11.232 0 0
HSF1-dependent transactivation R-HSA-3371571 6.045942e-12 11.219 0 0
Metabolism of RNA R-HSA-8953854 1.180533e-11 10.928 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.416667e-11 10.617 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.437883e-11 10.464 0 0
Attenuation phase R-HSA-3371568 5.744427e-11 10.241 0 0
Translation initiation complex formation R-HSA-72649 9.173984e-11 10.037 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.044592e-10 9.981 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.242166e-10 9.906 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.656527e-10 9.781 0 0
Cellular Senescence R-HSA-2559583 1.837539e-10 9.736 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.987775e-10 9.702 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.194404e-10 9.659 0 0
Cell-cell junction organization R-HSA-421270 2.497468e-10 9.603 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.837873e-10 9.416 0 0
Ribosome-associated quality control R-HSA-9948299 3.799437e-10 9.420 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.694405e-10 9.328 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.456300e-10 9.190 0 0
HSF1 activation R-HSA-3371511 9.684303e-10 9.014 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.751729e-09 8.757 0 0
Separation of Sister Chromatids R-HSA-2467813 1.932119e-09 8.714 0 0
Mitotic Prometaphase R-HSA-68877 2.019836e-09 8.695 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.751601e-09 8.560 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.191370e-09 8.496 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.204055e-09 8.494 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.390001e-09 8.470 0 0
Nucleosome assembly R-HSA-774815 3.390001e-09 8.470 0 0
Peptide chain elongation R-HSA-156902 3.459244e-09 8.461 0 0
Mitotic Anaphase R-HSA-68882 3.698311e-09 8.432 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.344409e-09 8.362 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.496788e-09 8.347 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.976811e-09 8.303 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.526635e-09 8.258 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.642591e-09 8.117 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.138851e-09 8.089 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.135652e-09 8.090 0 0
HDACs deacetylate histones R-HSA-3214815 8.240988e-09 8.084 0 0
Interleukin-12 signaling R-HSA-9020591 1.037605e-08 7.984 0 0
Ub-specific processing proteases R-HSA-5689880 1.201066e-08 7.920 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.184603e-08 7.926 0 0
Influenza Infection R-HSA-168255 1.414604e-08 7.849 0 0
G2/M Transition R-HSA-69275 1.948016e-08 7.710 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.261321e-08 7.646 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.657767e-08 7.575 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.705554e-08 7.568 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.705554e-08 7.568 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.843213e-08 7.546 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.874999e-08 7.541 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.293280e-08 7.482 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.607128e-08 7.443 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.810355e-08 7.419 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.084045e-08 7.389 0 0
Deubiquitination R-HSA-5688426 5.142227e-08 7.289 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.747669e-08 7.241 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.771699e-08 7.109 0 0
Interleukin-12 family signaling R-HSA-447115 7.762957e-08 7.110 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.950558e-08 7.100 0 0
Signaling by ALK in cancer R-HSA-9700206 7.950558e-08 7.100 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.460556e-08 7.073 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.460556e-08 7.073 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.550164e-08 7.068 0 0
Mitotic Prophase R-HSA-68875 9.291636e-08 7.032 0 0
Diseases of programmed cell death R-HSA-9645723 9.882953e-08 7.005 0 0
Defective pyroptosis R-HSA-9710421 1.031011e-07 6.987 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.109386e-07 6.955 0 0
Developmental Biology R-HSA-1266738 1.141035e-07 6.943 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.322723e-07 6.879 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.951615e-07 6.710 0 0
Regulation of CDH1 Function R-HSA-9764561 1.972074e-07 6.705 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.013048e-07 6.696 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.491962e-07 6.603 0 0
DNA methylation R-HSA-5334118 2.635707e-07 6.579 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.716788e-07 6.566 0 0
Eukaryotic Translation Termination R-HSA-72764 2.718444e-07 6.566 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.778096e-07 6.556 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.898663e-07 6.538 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.121800e-07 6.506 0 0
Semaphorin interactions R-HSA-373755 3.286130e-07 6.483 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.513088e-07 6.454 0 0
Co-inhibition by PD-1 R-HSA-389948 3.768451e-07 6.424 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.423093e-07 6.354 0 0
Packaging Of Telomere Ends R-HSA-171306 5.026647e-07 6.299 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.037059e-07 6.298 0 0
RNA Polymerase I Transcription R-HSA-73864 5.268846e-07 6.278 0 0
Muscle contraction R-HSA-397014 5.119686e-07 6.291 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.687778e-07 6.175 0 0
Meiotic synapsis R-HSA-1221632 6.951500e-07 6.158 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.687778e-07 6.175 0 0
DNA Replication R-HSA-69306 7.788901e-07 6.109 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.439813e-07 6.074 0 0
Chromatin organization R-HSA-4839726 8.456737e-07 6.073 0 0
EPH-Ephrin signaling R-HSA-2682334 8.625918e-07 6.064 0 0
MAPK family signaling cascades R-HSA-5683057 8.900490e-07 6.051 0 0
DNA Double Strand Break Response R-HSA-5693606 9.416676e-07 6.026 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.577264e-07 6.019 0 0
Selenocysteine synthesis R-HSA-2408557 9.536198e-07 6.021 0 0
Meiotic recombination R-HSA-912446 1.303950e-06 5.885 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.330557e-06 5.876 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.404617e-06 5.852 0 0
Viral mRNA Translation R-HSA-192823 1.415470e-06 5.849 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.560234e-06 5.807 0 0
Striated Muscle Contraction R-HSA-390522 1.839183e-06 5.735 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.966412e-06 5.706 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.107647e-06 5.676 0 0
Meiosis R-HSA-1500620 2.560247e-06 5.592 0 0
UCH proteinases R-HSA-5689603 2.746068e-06 5.561 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.259872e-06 5.487 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.445116e-06 5.463 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.684134e-06 5.434 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.522016e-06 5.453 0 0
Viral Infection Pathways R-HSA-9824446 3.897942e-06 5.409 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.946509e-06 5.404 0 0
Chromatin modifying enzymes R-HSA-3247509 4.140567e-06 5.383 0 0
HATs acetylate histones R-HSA-3214847 4.272119e-06 5.369 0 0
L1CAM interactions R-HSA-373760 4.284508e-06 5.368 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.706263e-06 5.327 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.556404e-06 5.255 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.831418e-06 5.234 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.594140e-06 5.252 0 0
Signal Transduction R-HSA-162582 5.671466e-06 5.246 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.040344e-06 5.219 0 0
Nephrin family interactions R-HSA-373753 6.689347e-06 5.175 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.714900e-06 5.173 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.804197e-06 5.167 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.804197e-06 5.167 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.998119e-06 5.155 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.372890e-06 5.132 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.372890e-06 5.132 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.046599e-06 5.094 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.439674e-06 5.074 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.839986e-06 5.054 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.289214e-06 5.032 0 0
G1/S Transition R-HSA-69206 9.510059e-06 5.022 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.560768e-06 5.020 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.962984e-06 5.002 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.021196e-05 4.991 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.195540e-05 4.922 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.203361e-05 4.920 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.213979e-05 4.916 0 0
Depyrimidination R-HSA-73928 1.213979e-05 4.916 0 0
rRNA processing R-HSA-72312 1.223802e-05 4.912 0 0
mRNA Splicing R-HSA-72172 1.295027e-05 4.888 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.381966e-05 4.860 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.488250e-05 4.827 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.661383e-05 4.780 0 0
Aggrephagy R-HSA-9646399 1.717522e-05 4.765 0 0
Signaling by Interleukins R-HSA-449147 1.953254e-05 4.709 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.975187e-05 4.704 0 0
Gene Silencing by RNA R-HSA-211000 2.089207e-05 4.680 0 0
Chromosome Maintenance R-HSA-73886 2.225384e-05 4.653 0 0
Cleavage of the damaged purine R-HSA-110331 2.425654e-05 4.615 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.640655e-05 4.578 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.640655e-05 4.578 0 0
Gene expression (Transcription) R-HSA-74160 2.667031e-05 4.574 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.941138e-05 4.531 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.992241e-05 4.524 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.041466e-05 4.517 0 0
Post NMDA receptor activation events R-HSA-438064 3.117891e-05 4.506 0 0
Homology Directed Repair R-HSA-5693538 3.145528e-05 4.502 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.351391e-05 4.475 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.515797e-05 4.454 0 0
Depurination R-HSA-73927 3.230440e-05 4.491 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.521033e-05 4.453 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.521033e-05 4.453 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.521033e-05 4.453 0 0
Signaling by RAS mutants R-HSA-6802949 3.521033e-05 4.453 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.051478e-05 4.392 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.236693e-05 4.373 0 0
Centrosome maturation R-HSA-380287 4.365406e-05 4.360 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.365406e-05 4.360 0 0
Recycling pathway of L1 R-HSA-437239 4.514421e-05 4.345 0 0
Signaling by VEGF R-HSA-194138 4.671608e-05 4.331 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.984596e-05 4.302 0 0
Orc1 removal from chromatin R-HSA-68949 5.047357e-05 4.297 0 0
Reproduction R-HSA-1474165 5.091642e-05 4.293 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.351282e-05 4.272 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.351282e-05 4.272 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.273649e-05 4.202 0 0
Degradation of CDH1 R-HSA-9766229 7.278183e-05 4.138 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.066365e-05 4.151 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.755475e-05 4.170 0 0
RMTs methylate histone arginines R-HSA-3214858 6.491768e-05 4.188 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.607517e-05 4.119 0 0
S Phase R-HSA-69242 8.111233e-05 4.091 0 0
DNA Repair R-HSA-73894 8.213972e-05 4.085 0 0
Selective autophagy R-HSA-9663891 9.003743e-05 4.046 0 0
PKR-mediated signaling R-HSA-9833482 1.099146e-04 3.959 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.252519e-04 3.902 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.254973e-04 3.901 0 0
Signaling by WNT R-HSA-195721 1.340509e-04 3.873 0 0
Cellular response to starvation R-HSA-9711097 1.381749e-04 3.860 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.382191e-04 3.859 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.392048e-04 3.856 0 0
Translation R-HSA-72766 1.400776e-04 3.854 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.423048e-04 3.847 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.423967e-04 3.847 0 0
Host Interactions of HIV factors R-HSA-162909 1.591916e-04 3.798 0 0
Signaling by Hippo R-HSA-2028269 1.671025e-04 3.777 0 0
Smooth Muscle Contraction R-HSA-445355 1.761048e-04 3.754 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.799788e-04 3.745 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.934069e-04 3.714 0 0
Telomere Maintenance R-HSA-157579 2.252292e-04 3.647 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.166375e-04 3.664 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.166375e-04 3.664 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.430986e-04 3.614 0 0
Ephrin signaling R-HSA-3928664 2.430986e-04 3.614 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.456007e-04 3.610 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.456007e-04 3.610 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.486015e-04 3.604 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.720990e-04 3.565 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.767439e-04 3.558 0 0
Signaling by NOTCH R-HSA-157118 2.977484e-04 3.526 0 0
RNA Polymerase II Transcription R-HSA-73857 3.052063e-04 3.515 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.068090e-04 3.513 0 0
Amyloid fiber formation R-HSA-977225 3.089482e-04 3.510 0 0
Metalloprotease DUBs R-HSA-5689901 3.306782e-04 3.481 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.308833e-04 3.480 0 0
Membrane Trafficking R-HSA-199991 3.791369e-04 3.421 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.842482e-04 3.415 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.842482e-04 3.415 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.010415e-04 3.397 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.254192e-04 3.371 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.396549e-04 3.357 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.602430e-04 3.337 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.646093e-04 3.333 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.667520e-04 3.331 0 0
Signal transduction by L1 R-HSA-445144 4.843649e-04 3.315 0 0
Selenoamino acid metabolism R-HSA-2408522 5.109666e-04 3.292 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.200166e-04 3.284 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.333637e-04 3.198 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.333637e-04 3.198 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.274992e-04 3.202 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.581644e-04 3.182 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.581644e-04 3.182 0 0
Protein ubiquitination R-HSA-8852135 6.280507e-04 3.202 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.763495e-04 3.239 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.495154e-04 3.187 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.650636e-04 3.177 0 0
ESR-mediated signaling R-HSA-8939211 6.672115e-04 3.176 0 0
Signaling by ERBB2 R-HSA-1227986 6.776238e-04 3.169 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.811976e-04 3.167 0 0
HCMV Early Events R-HSA-9609690 7.053558e-04 3.152 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.273904e-04 3.138 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.273904e-04 3.138 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.638376e-04 3.117 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.638376e-04 3.117 0 0
MAP2K and MAPK activation R-HSA-5674135 7.768830e-04 3.110 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.768830e-04 3.110 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.768830e-04 3.110 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.828971e-04 3.106 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.047276e-04 3.094 0 0
SARS-CoV Infections R-HSA-9679506 8.091392e-04 3.092 0 0
HIV Infection R-HSA-162906 8.110902e-04 3.091 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.162528e-04 3.088 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.170693e-04 3.088 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.331302e-04 3.079 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.446200e-04 3.073 0 0
Neutrophil degranulation R-HSA-6798695 8.758327e-04 3.058 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.927275e-04 3.049 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.955417e-04 3.048 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.256007e-04 3.034 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.256007e-04 3.034 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.563790e-04 3.019 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.838671e-04 3.007 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.028815e-03 2.988 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.044348e-03 2.981 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.044348e-03 2.981 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.063416e-03 2.973 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.129612e-03 2.947 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.178651e-03 2.929 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.063416e-03 2.973 0 0
Nef and signal transduction R-HSA-164944 1.207287e-03 2.918 0 0
Interferon Signaling R-HSA-913531 1.155639e-03 2.937 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.182710e-03 2.927 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.275659e-03 2.894 0 0
Cilium Assembly R-HSA-5617833 1.233546e-03 2.909 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.327922e-03 2.877 0 0
Regulation of Apoptosis R-HSA-169911 1.327922e-03 2.877 0 0
Base Excision Repair R-HSA-73884 1.350018e-03 2.870 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.405291e-03 2.852 0 0
TCR signaling R-HSA-202403 1.451784e-03 2.838 0 0
Hedgehog 'off' state R-HSA-5610787 1.509247e-03 2.821 0 0
G0 and Early G1 R-HSA-1538133 1.549592e-03 2.810 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.640430e-03 2.785 0 0
Josephin domain DUBs R-HSA-5689877 1.640430e-03 2.785 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.640430e-03 2.785 0 0
G1/S-Specific Transcription R-HSA-69205 1.645284e-03 2.784 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.645284e-03 2.784 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.724834e-03 2.763 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.724834e-03 2.763 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.818800e-03 2.740 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.818800e-03 2.740 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.823013e-03 2.739 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.823013e-03 2.739 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.893142e-03 2.723 0 0
Ion homeostasis R-HSA-5578775 1.970582e-03 2.705 0 0
Protein folding R-HSA-391251 1.996130e-03 2.700 0 0
Synthesis of DNA R-HSA-69239 1.996483e-03 2.700 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.023331e-03 2.694 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.030939e-03 2.692 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.060187e-03 2.686 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.060187e-03 2.686 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.166588e-03 2.664 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.277474e-03 2.643 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.298643e-03 2.639 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.308904e-03 2.637 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.315210e-03 2.635 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.318289e-03 2.635 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.399639e-03 2.620 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.401067e-03 2.620 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.441734e-03 2.612 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.458255e-03 2.609 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.472496e-03 2.607 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.479292e-03 2.606 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.587545e-03 2.587 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.587545e-03 2.587 0 0
Signaling by PTK6 R-HSA-8848021 2.587545e-03 2.587 0 0
Long-term potentiation R-HSA-9620244 2.614697e-03 2.583 0 0
Generic Transcription Pathway R-HSA-212436 2.630804e-03 2.580 0 0
Interleukin-37 signaling R-HSA-9008059 2.831879e-03 2.548 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.840137e-03 2.547 0 0
DCC mediated attractive signaling R-HSA-418885 3.554703e-03 2.449 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.554703e-03 2.449 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.554703e-03 2.449 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.996248e-03 2.523 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.310272e-03 2.480 0 0
Myogenesis R-HSA-525793 3.311939e-03 2.480 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.554814e-03 2.449 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.996248e-03 2.523 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.310272e-03 2.480 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.996248e-03 2.523 0 0
Stabilization of p53 R-HSA-69541 2.996248e-03 2.523 0 0
Glycolysis R-HSA-70171 2.987540e-03 2.525 0 0
Regulation of TP53 Activity R-HSA-5633007 3.496696e-03 2.456 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.554703e-03 2.449 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.554703e-03 2.449 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.952505e-03 2.530 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.596442e-03 2.444 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.596442e-03 2.444 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.603058e-03 2.443 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.610200e-03 2.442 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.610200e-03 2.442 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.610200e-03 2.442 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.827389e-03 2.417 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.003071e-03 2.398 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.064679e-03 2.391 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.216287e-03 2.375 0 0
MAP kinase activation R-HSA-450294 4.264449e-03 2.370 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.322968e-03 2.364 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.322968e-03 2.364 0 0
Rap1 signalling R-HSA-392517 4.345977e-03 2.362 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.365211e-03 2.360 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.520049e-03 2.345 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.760816e-03 2.322 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.888487e-03 2.311 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.997106e-03 2.301 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.252193e-03 2.280 0 0
Degradation of DVL R-HSA-4641258 5.252193e-03 2.280 0 0
Degradation of AXIN R-HSA-4641257 5.252193e-03 2.280 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.266023e-03 2.279 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.266023e-03 2.279 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.796945e-03 2.237 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.103185e-03 2.214 0 0
Neurodegenerative Diseases R-HSA-8863678 6.103185e-03 2.214 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.103185e-03 2.214 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.149522e-03 2.211 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.277921e-03 2.202 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.332165e-03 2.198 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.372422e-03 2.196 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.505779e-03 2.187 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.832470e-03 2.165 0 0
Signaling by Hedgehog R-HSA-5358351 6.859168e-03 2.164 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.981526e-03 2.156 0 0
Autophagy R-HSA-9612973 7.115945e-03 2.148 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.160602e-03 2.145 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.168484e-03 2.145 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.169527e-03 2.145 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.169527e-03 2.145 0 0
Potential therapeutics for SARS R-HSA-9679191 7.246765e-03 2.140 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 7.850262e-03 2.105 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.328396e-03 2.030 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.716011e-03 2.113 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.654756e-03 2.116 0 0
Dual Incision in GG-NER R-HSA-5696400 7.654756e-03 2.116 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.131061e-03 2.039 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.393527e-03 2.076 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.393527e-03 2.076 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.872093e-03 2.104 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.007339e-03 2.045 0 0
TNF signaling R-HSA-75893 9.839169e-03 2.007 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.804277e-03 2.055 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.836128e-03 2.106 0 0
PTEN Regulation R-HSA-6807070 7.482595e-03 2.126 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.760654e-03 2.110 0 0
HIV Life Cycle R-HSA-162587 7.719705e-03 2.112 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.839169e-03 2.007 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.197807e-03 2.036 0 0
Macroautophagy R-HSA-1632852 8.870929e-03 2.052 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.778385e-03 2.010 0 0
Signalling to ERKs R-HSA-187687 9.131061e-03 2.039 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.609573e-03 2.065 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.609573e-03 2.065 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.609573e-03 2.065 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.778385e-03 2.010 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.934038e-03 2.101 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.934038e-03 2.101 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.222228e-03 2.085 0 0
Hedgehog 'on' state R-HSA-5632684 7.748914e-03 2.111 0 0
Interleukin-1 family signaling R-HSA-446652 8.541581e-03 2.068 0 0
Cellular response to chemical stress R-HSA-9711123 9.868782e-03 2.006 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.940245e-03 2.003 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.940245e-03 2.003 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.940245e-03 2.003 0 0
PECAM1 interactions R-HSA-210990 1.006481e-02 1.997 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.024730e-02 1.989 0 0
Nucleotide Excision Repair R-HSA-5696398 1.051497e-02 1.978 0 0
ABC-family proteins mediated transport R-HSA-382556 1.053466e-02 1.977 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.058616e-02 1.975 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.058616e-02 1.975 0 0
HCMV Infection R-HSA-9609646 1.097974e-02 1.959 0 0
Signaling by NOTCH4 R-HSA-9013694 1.110855e-02 1.954 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.117950e-02 1.952 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.119356e-02 1.951 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.119356e-02 1.951 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.133653e-02 1.946 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.133967e-02 1.945 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.176153e-02 1.930 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.206638e-02 1.918 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.215060e-02 1.915 0 0
mRNA 3'-end processing R-HSA-72187 1.215060e-02 1.915 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.215060e-02 1.915 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.223575e-02 1.912 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.223575e-02 1.912 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.273997e-02 1.895 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.273997e-02 1.895 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.278512e-02 1.893 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.317210e-02 1.880 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.330429e-02 1.876 0 0
Translesion Synthesis by POLH R-HSA-110320 1.335461e-02 1.874 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.335461e-02 1.874 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.335461e-02 1.874 0 0
Interleukin-17 signaling R-HSA-448424 1.366871e-02 1.864 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.368099e-02 1.864 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.370668e-02 1.863 0 0
NF-kB is activated and signals survival R-HSA-209560 1.370668e-02 1.863 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.370668e-02 1.863 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.370668e-02 1.863 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.388992e-02 1.857 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.388992e-02 1.857 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.392591e-02 1.856 0 0
Ca-dependent events R-HSA-111996 1.401307e-02 1.853 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.444912e-02 1.840 0 0
snRNP Assembly R-HSA-191859 1.451641e-02 1.838 0 0
Metabolism of non-coding RNA R-HSA-194441 1.451641e-02 1.838 0 0
Cellular response to hypoxia R-HSA-1234174 1.498547e-02 1.824 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.523732e-02 1.817 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.523732e-02 1.817 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.523732e-02 1.817 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.523732e-02 1.817 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.524157e-02 1.817 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.531924e-02 1.815 0 0
Opioid Signalling R-HSA-111885 1.542510e-02 1.812 0 0
Negative regulation of FLT3 R-HSA-9706369 1.574500e-02 1.803 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.619172e-02 1.791 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.631528e-02 1.787 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.636662e-02 1.786 0 0
Late endosomal microautophagy R-HSA-9615710 1.636662e-02 1.786 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.638272e-02 1.786 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.640961e-02 1.785 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.661130e-02 1.780 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.712135e-02 1.766 0 0
Gap junction trafficking and regulation R-HSA-157858 1.718877e-02 1.765 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.818008e-02 1.740 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.818008e-02 1.740 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.818008e-02 1.740 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.818008e-02 1.740 0 0
RAF activation R-HSA-5673000 1.845379e-02 1.734 0 0
Nuclear import of Rev protein R-HSA-180746 1.845379e-02 1.734 0 0
Mitophagy R-HSA-5205647 1.845379e-02 1.734 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.848780e-02 1.733 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.848780e-02 1.733 0 0
Gap junction trafficking R-HSA-190828 1.861853e-02 1.730 0 0
Activation of the pre-replicative complex R-HSA-68962 1.942400e-02 1.712 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.942400e-02 1.712 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.942400e-02 1.712 0 0
Activation of BH3-only proteins R-HSA-114452 1.942400e-02 1.712 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.007847e-02 1.697 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.007847e-02 1.697 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.015760e-02 1.696 0 0
Gap junction degradation R-HSA-190873 2.015760e-02 1.696 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.015760e-02 1.696 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.015760e-02 1.696 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.027168e-02 1.693 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.027889e-02 1.693 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.759021e-02 1.559 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.759021e-02 1.559 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.759021e-02 1.559 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.759021e-02 1.559 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.759021e-02 1.559 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.759021e-02 1.559 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.759021e-02 1.559 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.712151e-02 1.567 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.712151e-02 1.567 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.957024e-02 1.529 0 0
Signaling by LTK in cancer R-HSA-9842640 2.957024e-02 1.529 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.716949e-02 1.566 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.716949e-02 1.566 0 0
Frs2-mediated activation R-HSA-170968 2.356172e-02 1.628 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.991822e-02 1.524 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.479810e-02 1.606 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.040425e-02 1.690 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.040425e-02 1.690 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.477443e-02 1.606 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.842467e-02 1.546 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.287980e-02 1.641 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.287980e-02 1.641 0 0
RET signaling R-HSA-8853659 2.495214e-02 1.603 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.017565e-02 1.520 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.754687e-02 1.560 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.287980e-02 1.641 0 0
FLT3 Signaling R-HSA-9607240 2.311347e-02 1.636 0 0
FLT3 signaling in disease R-HSA-9682385 2.495214e-02 1.603 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.311347e-02 1.636 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.036214e-02 1.691 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.991822e-02 1.524 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.311347e-02 1.636 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.737476e-02 1.563 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.044452e-02 1.516 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.152345e-02 1.667 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.287980e-02 1.641 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.884129e-02 1.540 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.884129e-02 1.540 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.991822e-02 1.524 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.934102e-02 1.533 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.036214e-02 1.691 0 0
Platelet sensitization by LDL R-HSA-432142 3.044452e-02 1.516 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.287980e-02 1.641 0 0
Adaptive Immune System R-HSA-1280218 2.209055e-02 1.656 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.477443e-02 1.606 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.036214e-02 1.691 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.428052e-02 1.615 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.605526e-02 1.584 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.402821e-02 1.619 0 0
Calmodulin induced events R-HSA-111933 2.495214e-02 1.603 0 0
Death Receptor Signaling R-HSA-73887 2.561234e-02 1.592 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.959628e-02 1.529 0 0
CaM pathway R-HSA-111997 2.495214e-02 1.603 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.985472e-02 1.525 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.152108e-02 1.667 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.716949e-02 1.566 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.825862e-02 1.549 0 0
Glucose metabolism R-HSA-70326 2.105133e-02 1.677 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.152108e-02 1.667 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.510006e-02 1.600 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.106347e-02 1.676 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.886139e-02 1.540 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.356172e-02 1.628 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.130953e-02 1.671 0 0
Specification of primordial germ cells R-HSA-9827857 2.479810e-02 1.606 0 0
Maturation of protein E R-HSA-9683683 2.036214e-02 1.691 0 0
Maturation of protein E R-HSA-9694493 2.036214e-02 1.691 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.108767e-02 1.507 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.108767e-02 1.507 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.108767e-02 1.507 0 0
HCMV Late Events R-HSA-9610379 3.127544e-02 1.505 0 0
PCP/CE pathway R-HSA-4086400 3.159834e-02 1.500 0 0
Kinesins R-HSA-983189 3.198069e-02 1.495 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.335638e-02 1.477 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.335638e-02 1.477 0 0
Downstream TCR signaling R-HSA-202424 3.351612e-02 1.475 0 0
Sensory processing of sound R-HSA-9659379 3.470039e-02 1.460 0 0
DNA Damage Bypass R-HSA-73893 3.502448e-02 1.456 0 0
PLC beta mediated events R-HSA-112043 3.555202e-02 1.449 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.556463e-02 1.449 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.556463e-02 1.449 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.588650e-02 1.445 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.588650e-02 1.445 0 0
Regulation of signaling by CBL R-HSA-912631 3.689593e-02 1.433 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.730455e-02 1.428 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.730455e-02 1.428 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.730455e-02 1.428 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.730455e-02 1.428 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.730455e-02 1.428 0 0
Translesion synthesis by REV1 R-HSA-110312 3.730455e-02 1.428 0 0
Protein methylation R-HSA-8876725 3.730455e-02 1.428 0 0
p38MAPK events R-HSA-171007 3.730455e-02 1.428 0 0
p75NTR signals via NF-kB R-HSA-193639 3.730455e-02 1.428 0 0
Signaling by ALK R-HSA-201556 3.759520e-02 1.425 0 0
Signaling by FGFR2 R-HSA-5654738 3.802079e-02 1.420 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.802079e-02 1.420 0 0
Proteasome assembly R-HSA-9907900 3.867247e-02 1.413 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.872383e-02 1.412 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.884919e-02 1.411 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.884919e-02 1.411 0 0
Signaling by EGFR R-HSA-177929 3.947867e-02 1.404 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.088198e-02 1.388 0 0
Regulation of PTEN localization R-HSA-8948747 4.088198e-02 1.388 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.117668e-02 1.385 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.170826e-02 1.380 0 0
Deadenylation of mRNA R-HSA-429947 4.170826e-02 1.380 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.170826e-02 1.380 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.241395e-02 1.372 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.273902e-02 1.369 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.349709e-02 1.362 0 0
DAG and IP3 signaling R-HSA-1489509 4.349709e-02 1.362 0 0
Somitogenesis R-HSA-9824272 4.349709e-02 1.362 0 0
Immune System R-HSA-168256 4.378225e-02 1.359 0 0
Activation of RAC1 R-HSA-428540 4.539757e-02 1.343 0 0
Translesion synthesis by POLI R-HSA-5656121 4.576307e-02 1.339 0 0
Prolonged ERK activation events R-HSA-169893 4.576307e-02 1.339 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.628079e-02 1.335 0 0
Infectious disease R-HSA-5663205 4.662868e-02 1.331 0 0
Oncogene Induced Senescence R-HSA-2559585 4.697656e-02 1.328 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.798474e-02 1.319 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.105110e-02 1.292 0 0
Toll-like Receptor Cascades R-HSA-168898 5.113341e-02 1.291 0 0
Trafficking of AMPA receptors R-HSA-399719 5.160606e-02 1.287 0 0
ER-Phagosome pathway R-HSA-1236974 5.210671e-02 1.283 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.234635e-02 1.281 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.234635e-02 1.281 0 0
Formation of annular gap junctions R-HSA-196025 5.432252e-02 1.265 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.432252e-02 1.265 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.432252e-02 1.265 0 0
Modulation by Mtb of host immune system R-HSA-9637628 5.432252e-02 1.265 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.432252e-02 1.265 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.532282e-02 1.257 0 0
Translesion synthesis by POLK R-HSA-5655862 5.532282e-02 1.257 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.532282e-02 1.257 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.532282e-02 1.257 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.532282e-02 1.257 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.545290e-02 1.256 0 0
Signaling by TGFB family members R-HSA-9006936 5.634757e-02 1.249 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.646917e-02 1.248 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.669737e-02 1.246 0 0
Interleukin-1 signaling R-HSA-9020702 5.685390e-02 1.245 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.714402e-02 1.243 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 5.714402e-02 1.243 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.714402e-02 1.243 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.773373e-02 1.239 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.890554e-02 1.230 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.890554e-02 1.230 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.016657e-02 1.221 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.059572e-02 1.218 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.139206e-02 1.212 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.139206e-02 1.212 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.139206e-02 1.212 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.157921e-02 1.211 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.193399e-02 1.208 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.193399e-02 1.208 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.193399e-02 1.208 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.242874e-02 1.205 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.242874e-02 1.205 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.242874e-02 1.205 0 0
Vesicle-mediated transport R-HSA-5653656 6.275155e-02 1.202 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.291987e-02 1.201 0 0
G-protein mediated events R-HSA-112040 6.318182e-02 1.199 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.334338e-02 1.198 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.394290e-02 1.194 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.394290e-02 1.194 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.394290e-02 1.194 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.495096e-02 1.187 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.495096e-02 1.187 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.592795e-02 1.181 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.683647e-02 1.175 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.683647e-02 1.175 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.683647e-02 1.175 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.683647e-02 1.175 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.695351e-02 1.174 0 0
Signaling by FGFR4 R-HSA-5654743 6.753199e-02 1.170 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.937979e-02 1.159 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.946828e-02 1.158 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.946828e-02 1.158 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.986282e-02 1.156 0 0
Unwinding of DNA R-HSA-176974 6.986282e-02 1.156 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.986282e-02 1.156 0 0
tRNA processing in the nucleus R-HSA-6784531 7.073689e-02 1.150 0 0
FGFR2 alternative splicing R-HSA-6803529 7.133554e-02 1.147 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.263431e-02 1.139 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.263431e-02 1.139 0 0
Netrin-1 signaling R-HSA-373752 7.496038e-02 1.125 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.544867e-02 1.122 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.544867e-02 1.122 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.555156e-02 1.122 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.779472e-02 1.109 0 0
GAB1 signalosome R-HSA-180292 7.779472e-02 1.109 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.779472e-02 1.109 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.779472e-02 1.109 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.820359e-02 1.107 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.040733e-02 1.095 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.217945e-02 1.085 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.217945e-02 1.085 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.288582e-02 1.082 0 0
Signaling by FGFR3 R-HSA-5654741 8.288582e-02 1.082 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.369111e-02 1.077 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.369111e-02 1.077 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.369111e-02 1.077 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.369111e-02 1.077 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.416276e-02 1.075 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.416276e-02 1.075 0 0
DARPP-32 events R-HSA-180024 8.416276e-02 1.075 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.442519e-02 1.074 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 8.442519e-02 1.074 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.442519e-02 1.074 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 8.442519e-02 1.074 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.462143e-02 1.073 0 0
Gap junction assembly R-HSA-190861 8.462143e-02 1.073 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.462143e-02 1.073 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.531190e-02 1.069 0 0
Dual incision in TC-NER R-HSA-6782135 8.660887e-02 1.062 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.199761e-01 0.921 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.199761e-01 0.921 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.199761e-01 0.921 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.199761e-01 0.921 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.199761e-01 0.921 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.199761e-01 0.921 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.199761e-01 0.921 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.199761e-01 0.921 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.199761e-01 0.921 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.199761e-01 0.921 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.199761e-01 0.921 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.199761e-01 0.921 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.199761e-01 0.921 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.199761e-01 0.921 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.199761e-01 0.921 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.199761e-01 0.921 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.199761e-01 0.921 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 9.360356e-02 1.029 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.348880e-01 0.870 0 0
MET interacts with TNS proteins R-HSA-8875513 1.348880e-01 0.870 0 0
MET activates PTPN11 R-HSA-8865999 1.348880e-01 0.870 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.098513e-01 0.959 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.098513e-01 0.959 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.742705e-02 1.058 0 0
2-LTR circle formation R-HSA-164843 8.742705e-02 1.058 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.378057e-01 0.861 0 0
Recycling of eIF2:GDP R-HSA-72731 1.378057e-01 0.861 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.378057e-01 0.861 0 0
Type I hemidesmosome assembly R-HSA-446107 1.678625e-01 0.775 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.678625e-01 0.775 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.678625e-01 0.775 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.678625e-01 0.775 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.281374e-01 0.892 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.281374e-01 0.892 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.069804e-02 1.042 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.163106e-01 0.934 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.163106e-01 0.934 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.509689e-01 0.821 0 0
Disorders of Nervous System Development R-HSA-9697154 1.509689e-01 0.821 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.509689e-01 0.821 0 0
Pervasive developmental disorders R-HSA-9005895 1.509689e-01 0.821 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.509689e-01 0.821 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.509689e-01 0.821 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.509689e-01 0.821 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.509689e-01 0.821 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.509689e-01 0.821 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.345710e-01 0.871 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.345710e-01 0.871 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.391822e-02 1.027 0 0
ERK/MAPK targets R-HSA-198753 1.197240e-01 0.922 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.357667e-01 0.867 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.200185e-01 0.921 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 1.745428e-01 0.758 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.527598e-01 0.816 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.343306e-01 0.872 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.343306e-01 0.872 0 0
HIV elongation arrest and recovery R-HSA-167287 1.494396e-01 0.826 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.494396e-01 0.826 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.131088e-02 1.039 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.131088e-02 1.039 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.248712e-01 0.904 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.718898e-02 1.012 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.318038e-02 1.031 0 0
Mismatch Repair R-HSA-5358508 1.745428e-01 0.758 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.278585e-01 0.893 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.540156e-01 0.812 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.562982e-01 0.806 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.333337e-01 0.875 0 0
Polo-like kinase mediated events R-HSA-156711 1.745428e-01 0.758 0 0
EGFR downregulation R-HSA-182971 1.063674e-01 0.973 0 0
Integration of provirus R-HSA-162592 1.281374e-01 0.892 0 0
Interleukin-23 signaling R-HSA-9020933 1.678625e-01 0.775 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.678625e-01 0.775 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.281374e-01 0.892 0 0
Regulation of CDH11 function R-HSA-9762292 8.742705e-02 1.058 0 0
Circadian clock R-HSA-9909396 1.020012e-01 0.991 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.676009e-01 0.776 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.676009e-01 0.776 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.676009e-01 0.776 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.676009e-01 0.776 0 0
Regulation of IFNG signaling R-HSA-877312 1.509689e-01 0.821 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.450822e-01 0.838 0 0
Regulated Necrosis R-HSA-5218859 1.150027e-01 0.939 0 0
Formation of definitive endoderm R-HSA-9823730 1.046860e-01 0.980 0 0
Co-stimulation by CD28 R-HSA-389356 1.096583e-01 0.960 0 0
GPVI-mediated activation cascade R-HSA-114604 1.049779e-01 0.979 0 0
Adrenoceptors R-HSA-390696 1.678625e-01 0.775 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 1.678625e-01 0.775 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 1.678625e-01 0.775 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.540156e-01 0.812 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.130534e-01 0.947 0 0
Signaling by NOTCH1 R-HSA-1980143 1.268323e-01 0.897 0 0
Ca2+ pathway R-HSA-4086398 1.619915e-01 0.791 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.540156e-01 0.812 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.523322e-01 0.817 0 0
mTORC1-mediated signalling R-HSA-166208 1.527598e-01 0.816 0 0
Platelet calcium homeostasis R-HSA-418360 1.653049e-01 0.782 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.703551e-01 0.769 0 0
The NLRP3 inflammasome R-HSA-844456 9.069804e-02 1.042 0 0
CHL1 interactions R-HSA-447041 1.378057e-01 0.861 0 0
G alpha (12/13) signalling events R-HSA-416482 9.155357e-02 1.038 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.666578e-01 0.778 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.676009e-01 0.776 0 0
Signaling by MET R-HSA-6806834 1.057530e-01 0.976 0 0
Gastrulation R-HSA-9758941 1.322710e-01 0.879 0 0
Apoptotic factor-mediated response R-HSA-111471 1.745428e-01 0.758 0 0
Platelet degranulation R-HSA-114608 1.523372e-01 0.817 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.002358e-01 0.999 0 0
Generation of second messenger molecules R-HSA-202433 1.531541e-01 0.815 0 0
Signaling by FGFR R-HSA-190236 1.671459e-01 0.777 0 0
Negative regulation of MET activity R-HSA-6807004 1.046860e-01 0.980 0 0
Presynaptic function of Kainate receptors R-HSA-500657 1.745428e-01 0.758 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.109450e-01 0.955 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.343306e-01 0.872 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.590260e-01 0.799 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.666578e-01 0.778 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.357667e-01 0.867 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.314821e-01 0.881 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.357667e-01 0.867 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.378057e-01 0.861 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.678625e-01 0.775 0 0
OAS antiviral response R-HSA-8983711 1.509689e-01 0.821 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.598231e-01 0.796 0 0
Disease R-HSA-1643685 1.666517e-01 0.778 0 0
Signaling by NOTCH3 R-HSA-9012852 1.152554e-01 0.938 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.932519e-02 1.003 0 0
Signaling by NTRKs R-HSA-166520 1.261661e-01 0.899 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.163106e-01 0.934 0 0
Ion transport by P-type ATPases R-HSA-936837 1.389107e-01 0.857 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.450822e-01 0.838 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.357667e-01 0.867 0 0
ABC transporter disorders R-HSA-5619084 9.155357e-02 1.038 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.509689e-01 0.821 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.509689e-01 0.821 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.509689e-01 0.821 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.318038e-02 1.031 0 0
Signalling to RAS R-HSA-167044 1.197240e-01 0.922 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.083234e-01 0.965 0 0
Pexophagy R-HSA-9664873 8.742705e-02 1.058 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.509689e-01 0.821 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.745428e-01 0.758 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.752093e-01 0.756 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.752093e-01 0.756 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.752093e-01 0.756 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.752093e-01 0.756 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.792965e-01 0.746 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.793159e-01 0.746 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.793159e-01 0.746 0 0
Regulation of gap junction activity R-HSA-191650 1.793159e-01 0.746 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.793159e-01 0.746 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.793159e-01 0.746 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.793159e-01 0.746 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.793159e-01 0.746 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.793159e-01 0.746 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.806992e-01 0.743 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.818803e-01 0.740 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.818803e-01 0.740 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.893405e-01 0.723 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.893405e-01 0.723 0 0
Cardiac conduction R-HSA-5576891 1.917311e-01 0.717 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.920347e-01 0.717 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.952500e-01 0.709 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.960420e-01 0.708 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.960420e-01 0.708 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.991770e-01 0.701 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.995963e-01 0.700 0 0
ALK mutants bind TKIs R-HSA-9700645 1.995963e-01 0.700 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.995963e-01 0.700 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.995963e-01 0.700 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.995963e-01 0.700 0 0
Regulation of KIT signaling R-HSA-1433559 2.006630e-01 0.698 0 0
Signal regulatory protein family interactions R-HSA-391160 2.006630e-01 0.698 0 0
Signaling by FGFR1 R-HSA-5654736 2.019304e-01 0.695 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.019304e-01 0.695 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.043027e-01 0.690 0 0
Interleukin-7 signaling R-HSA-1266695 2.087840e-01 0.680 0 0
DNA strand elongation R-HSA-69190 2.169554e-01 0.664 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.169554e-01 0.664 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.183964e-01 0.661 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.183964e-01 0.661 0 0
Glycogen synthesis R-HSA-3322077 2.183964e-01 0.661 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.255398e-01 0.647 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.255398e-01 0.647 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.255398e-01 0.647 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.255398e-01 0.647 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.255398e-01 0.647 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.255398e-01 0.647 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.255398e-01 0.647 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.255398e-01 0.647 0 0
Reelin signalling pathway R-HSA-8866376 2.255398e-01 0.647 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.255398e-01 0.647 0 0
Co-inhibition by BTLA R-HSA-9927353 2.255398e-01 0.647 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.255641e-01 0.647 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.255641e-01 0.647 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.255641e-01 0.647 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.255641e-01 0.647 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.255641e-01 0.647 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.255641e-01 0.647 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.255641e-01 0.647 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.255641e-01 0.647 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.255641e-01 0.647 0 0
Inhibition of PKR R-HSA-169131 2.255641e-01 0.647 0 0
Cyclin D associated events in G1 R-HSA-69231 2.257543e-01 0.646 0 0
G1 Phase R-HSA-69236 2.257543e-01 0.646 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.271297e-01 0.644 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.271297e-01 0.644 0 0
IRE1alpha activates chaperones R-HSA-381070 2.277394e-01 0.643 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.288926e-01 0.640 0 0
Developmental Cell Lineages R-HSA-9734767 2.297490e-01 0.639 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.325955e-01 0.633 0 0
Formation of apoptosome R-HSA-111458 2.325955e-01 0.633 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.325955e-01 0.633 0 0
Signal attenuation R-HSA-74749 2.325955e-01 0.633 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.325955e-01 0.633 0 0
Signaling by Leptin R-HSA-2586552 2.325955e-01 0.633 0 0
G-protein beta:gamma signalling R-HSA-397795 2.353431e-01 0.628 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.353431e-01 0.628 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.353431e-01 0.628 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.353431e-01 0.628 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.393069e-01 0.621 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.403915e-01 0.619 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.413719e-01 0.617 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.414855e-01 0.617 0 0
G-protein activation R-HSA-202040 2.414855e-01 0.617 0 0
Basigin interactions R-HSA-210991 2.414855e-01 0.617 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.414855e-01 0.617 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.428525e-01 0.615 0 0
Cristae formation R-HSA-8949613 2.495841e-01 0.603 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.495841e-01 0.603 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.524718e-01 0.598 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.544091e-01 0.594 0 0
Phosphorylation of the APC/C R-HSA-176412 2.544091e-01 0.594 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.544091e-01 0.594 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.544091e-01 0.594 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.544091e-01 0.594 0 0
Regulation of BACH1 activity R-HSA-9708530 2.544091e-01 0.594 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.552250e-01 0.593 0 0
Signaling by ERBB4 R-HSA-1236394 2.555521e-01 0.593 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.567438e-01 0.591 0 0
HIV Transcription Elongation R-HSA-167169 2.567438e-01 0.591 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.567438e-01 0.591 0 0
Platelet homeostasis R-HSA-418346 2.574073e-01 0.589 0 0
Diseases of DNA repair R-HSA-9675135 2.578998e-01 0.589 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.622204e-01 0.581 0 0
Assembly Of The HIV Virion R-HSA-175474 2.651868e-01 0.576 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.664726e-01 0.574 0 0
Signaling by APC mutants R-HSA-4839744 2.664726e-01 0.574 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.664726e-01 0.574 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.664726e-01 0.574 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.664726e-01 0.574 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.664726e-01 0.574 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.707748e-01 0.567 0 0
Inflammasomes R-HSA-622312 2.707748e-01 0.567 0 0
Aquaporin-mediated transport R-HSA-445717 2.724082e-01 0.565 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.724897e-01 0.565 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.724897e-01 0.565 0 0
Phosphorylation of Emi1 R-HSA-176417 2.724897e-01 0.565 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.724897e-01 0.565 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.724897e-01 0.565 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.724897e-01 0.565 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.724897e-01 0.565 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.724897e-01 0.565 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.724897e-01 0.565 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.724897e-01 0.565 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.735201e-01 0.563 0 0
Signaling by NOTCH2 R-HSA-1980145 2.735201e-01 0.563 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.796841e-01 0.553 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.823046e-01 0.549 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.823046e-01 0.549 0 0
Disorders of Developmental Biology R-HSA-9675151 2.823046e-01 0.549 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.823046e-01 0.549 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.823046e-01 0.549 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.849548e-01 0.545 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.874884e-01 0.541 0 0
GPER1 signaling R-HSA-9634597 2.913901e-01 0.536 0 0
Gluconeogenesis R-HSA-70263 2.913901e-01 0.536 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.923801e-01 0.534 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.923801e-01 0.534 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.923801e-01 0.534 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.008698e-01 0.522 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.008698e-01 0.522 0 0
ERKs are inactivated R-HSA-202670 3.008698e-01 0.522 0 0
Signaling by AXIN mutants R-HSA-4839735 3.008698e-01 0.522 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.008698e-01 0.522 0 0
NRAGE signals death through JNK R-HSA-193648 3.056556e-01 0.515 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.056816e-01 0.515 0 0
MHC class II antigen presentation R-HSA-2132295 3.056816e-01 0.515 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.100223e-01 0.509 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.106268e-01 0.508 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.106268e-01 0.508 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.106268e-01 0.508 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.106268e-01 0.508 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.106268e-01 0.508 0 0
Glycogen storage diseases R-HSA-3229121 3.106268e-01 0.508 0 0
Syndecan interactions R-HSA-3000170 3.139395e-01 0.503 0 0
Growth hormone receptor signaling R-HSA-982772 3.139395e-01 0.503 0 0
DAP12 signaling R-HSA-2424491 3.143155e-01 0.503 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.184888e-01 0.497 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.184888e-01 0.497 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.184888e-01 0.497 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.184888e-01 0.497 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.184888e-01 0.497 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.184888e-01 0.497 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.184888e-01 0.497 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.184888e-01 0.497 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.184888e-01 0.497 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 3.184888e-01 0.497 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.184888e-01 0.497 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.184888e-01 0.497 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.184888e-01 0.497 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.193265e-01 0.496 0 0
STAT5 Activation R-HSA-9645135 3.193265e-01 0.496 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.193265e-01 0.496 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.193265e-01 0.496 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.193265e-01 0.496 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.193265e-01 0.496 0 0
CREB phosphorylation R-HSA-199920 3.193265e-01 0.496 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.193265e-01 0.496 0 0
Neurofascin interactions R-HSA-447043 3.193265e-01 0.496 0 0
Mitochondrial biogenesis R-HSA-1592230 3.213217e-01 0.493 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.219619e-01 0.492 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.287612e-01 0.483 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.290691e-01 0.483 0 0
Signaling by SCF-KIT R-HSA-1433557 3.297517e-01 0.482 0 0
TBC/RABGAPs R-HSA-8854214 3.297517e-01 0.482 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.297517e-01 0.482 0 0
Transmission across Chemical Synapses R-HSA-112315 3.347143e-01 0.475 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.354635e-01 0.474 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.354635e-01 0.474 0 0
Polymerase switching R-HSA-69091 3.354635e-01 0.474 0 0
Leading Strand Synthesis R-HSA-69109 3.354635e-01 0.474 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.354635e-01 0.474 0 0
Downstream signal transduction R-HSA-186763 3.364976e-01 0.473 0 0
Budding and maturation of HIV virion R-HSA-162588 3.364976e-01 0.473 0 0
PKA activation R-HSA-163615 3.391959e-01 0.470 0 0
PKA activation in glucagon signalling R-HSA-164378 3.391959e-01 0.470 0 0
Nephron development R-HSA-9831926 3.391959e-01 0.470 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.446443e-01 0.463 0 0
Protein localization R-HSA-9609507 3.503045e-01 0.456 0 0
MET promotes cell motility R-HSA-8875878 3.537328e-01 0.451 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.537328e-01 0.451 0 0
Signaling by FGFR in disease R-HSA-1226099 3.587340e-01 0.445 0 0
TGFBR3 expression R-HSA-9839394 3.637070e-01 0.439 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.654019e-01 0.437 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.654019e-01 0.437 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.654019e-01 0.437 0 0
Netrin mediated repulsion signals R-HSA-418886 3.654019e-01 0.437 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.654019e-01 0.437 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.654019e-01 0.437 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.654019e-01 0.437 0 0
PTK6 Expression R-HSA-8849473 3.654019e-01 0.437 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.654019e-01 0.437 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.654019e-01 0.437 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.654019e-01 0.437 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.654019e-01 0.437 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.654019e-01 0.437 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.654019e-01 0.437 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.675263e-01 0.435 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.675263e-01 0.435 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.678434e-01 0.434 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.678434e-01 0.434 0 0
Specification of the neural plate border R-HSA-9834899 3.678434e-01 0.434 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.678434e-01 0.434 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 3.678434e-01 0.434 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.678434e-01 0.434 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.678434e-01 0.434 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.696339e-01 0.432 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.699652e-01 0.432 0 0
Interleukin-6 signaling R-HSA-1059683 3.699652e-01 0.432 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.699652e-01 0.432 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.723431e-01 0.429 0 0
Pentose phosphate pathway R-HSA-71336 3.742266e-01 0.427 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.742266e-01 0.427 0 0
Integrin signaling R-HSA-354192 3.812791e-01 0.419 0 0
Signaling by TGFBR3 R-HSA-9839373 3.865616e-01 0.413 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.886937e-01 0.410 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.959500e-01 0.402 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.964134e-01 0.402 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.964134e-01 0.402 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.964134e-01 0.402 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 3.964134e-01 0.402 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.964134e-01 0.402 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.964134e-01 0.402 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.964134e-01 0.402 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.964134e-01 0.402 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.964134e-01 0.402 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.965760e-01 0.402 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.002681e-01 0.398 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.002681e-01 0.398 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.002681e-01 0.398 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.002681e-01 0.398 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 4.002681e-01 0.398 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 4.002681e-01 0.398 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.002681e-01 0.398 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.002681e-01 0.398 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.002681e-01 0.398 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.002681e-01 0.398 0 0
DSCAM interactions R-HSA-376172 4.002681e-01 0.398 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.002681e-01 0.398 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.002681e-01 0.398 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.041226e-01 0.393 0 0
HDL assembly R-HSA-8963896 4.041226e-01 0.393 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.042310e-01 0.393 0 0
Heme signaling R-HSA-9707616 4.054826e-01 0.392 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.056331e-01 0.392 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.056331e-01 0.392 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.102244e-01 0.387 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.102244e-01 0.387 0 0
phospho-PLA2 pathway R-HSA-111995 4.102244e-01 0.387 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.102244e-01 0.387 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.102244e-01 0.387 0 0
Interleukin-9 signaling R-HSA-8985947 4.102244e-01 0.387 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.102244e-01 0.387 0 0
RSK activation R-HSA-444257 4.102244e-01 0.387 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.136124e-01 0.383 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.136124e-01 0.383 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.136124e-01 0.383 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.153239e-01 0.382 0 0
Intraflagellar transport R-HSA-5620924 4.246958e-01 0.372 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.247638e-01 0.372 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.247638e-01 0.372 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.247638e-01 0.372 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.261073e-01 0.370 0 0
Signal amplification R-HSA-392518 4.261073e-01 0.370 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.261073e-01 0.370 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.261073e-01 0.370 0 0
FOXO-mediated transcription R-HSA-9614085 4.357577e-01 0.361 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.377183e-01 0.359 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.377183e-01 0.359 0 0
Formation of the anterior neural plate R-HSA-9823739 4.377183e-01 0.359 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.383691e-01 0.358 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.383691e-01 0.358 0 0
Pyroptosis R-HSA-5620971 4.383691e-01 0.358 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.383691e-01 0.358 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.383691e-01 0.358 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.437062e-01 0.353 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.483616e-01 0.348 0 0
PERK regulates gene expression R-HSA-381042 4.483616e-01 0.348 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.527664e-01 0.344 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.527664e-01 0.344 0 0
Lipophagy R-HSA-9613354 4.534315e-01 0.343 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.534315e-01 0.343 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.534315e-01 0.343 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.534315e-01 0.343 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.534315e-01 0.343 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.534315e-01 0.343 0 0
ARMS-mediated activation R-HSA-170984 4.534315e-01 0.343 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.534315e-01 0.343 0 0
Interleukin-1 processing R-HSA-448706 4.534315e-01 0.343 0 0
MTOR signalling R-HSA-165159 4.561990e-01 0.341 0 0
Glucagon-type ligand receptors R-HSA-420092 4.628771e-01 0.335 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.629054e-01 0.335 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.684501e-01 0.329 0 0
Hemostasis R-HSA-109582 4.690158e-01 0.329 0 0
Triglyceride catabolism R-HSA-163560 4.704230e-01 0.328 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.705684e-01 0.327 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.705684e-01 0.327 0 0
Activation of SMO R-HSA-5635838 4.705684e-01 0.327 0 0
MET activates STAT3 R-HSA-8875791 4.722384e-01 0.326 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.722384e-01 0.326 0 0
Axonal growth stimulation R-HSA-209563 4.722384e-01 0.326 0 0
Signalling to STAT3 R-HSA-198745 4.722384e-01 0.326 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.722384e-01 0.326 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.722384e-01 0.326 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.722384e-01 0.326 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.722384e-01 0.326 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.722384e-01 0.326 0 0
Intracellular oxygen transport R-HSA-8981607 4.722384e-01 0.326 0 0
Histamine receptors R-HSA-390650 4.722384e-01 0.326 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.803073e-01 0.318 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.803073e-01 0.318 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.803073e-01 0.318 0 0
Signaling by KIT in disease R-HSA-9669938 4.803073e-01 0.318 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.947656e-01 0.306 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.947656e-01 0.306 0 0
PI3K/AKT activation R-HSA-198203 4.947656e-01 0.306 0 0
Interleukin-27 signaling R-HSA-9020956 4.947656e-01 0.306 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.947656e-01 0.306 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.957142e-01 0.305 0 0
Interferon gamma signaling R-HSA-877300 4.963814e-01 0.304 0 0
Neurexins and neuroligins R-HSA-6794361 5.000194e-01 0.301 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.025203e-01 0.299 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.025203e-01 0.299 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.025203e-01 0.299 0 0
Metabolism of polyamines R-HSA-351202 5.031325e-01 0.298 0 0
Transcription of the HIV genome R-HSA-167172 5.059023e-01 0.296 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.072865e-01 0.295 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.072865e-01 0.295 0 0
Rab regulation of trafficking R-HSA-9007101 5.075517e-01 0.295 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.137363e-01 0.289 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.137363e-01 0.289 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.162234e-01 0.287 0 0
RSV-host interactions R-HSA-9833110 5.166363e-01 0.287 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.334506e-01 0.273 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.334506e-01 0.273 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.336178e-01 0.273 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.336178e-01 0.273 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.340541e-01 0.272 0 0
Formation of the posterior neural plate R-HSA-9832991 5.340541e-01 0.272 0 0
Bicarbonate transporters R-HSA-425381 5.340541e-01 0.272 0 0
Suppression of apoptosis R-HSA-9635465 5.340541e-01 0.272 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.340541e-01 0.272 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.340541e-01 0.272 0 0
Interleukin-2 signaling R-HSA-9020558 5.340541e-01 0.272 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.340541e-01 0.272 0 0
Signaling by WNT in cancer R-HSA-4791275 5.341566e-01 0.272 0 0
RAS processing R-HSA-9648002 5.348846e-01 0.272 0 0
HCN channels R-HSA-1296061 5.355756e-01 0.271 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.355756e-01 0.271 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.355756e-01 0.271 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.355756e-01 0.271 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.355756e-01 0.271 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.355756e-01 0.271 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.355756e-01 0.271 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.355756e-01 0.271 0 0
NADE modulates death signalling R-HSA-205025 5.355756e-01 0.271 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.355756e-01 0.271 0 0
Interleukin-38 signaling R-HSA-9007892 5.355756e-01 0.271 0 0
Mitochondrial protein import R-HSA-1268020 5.375058e-01 0.270 0 0
G alpha (z) signalling events R-HSA-418597 5.544963e-01 0.256 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.556331e-01 0.255 0 0
Interleukin-2 family signaling R-HSA-451927 5.556331e-01 0.255 0 0
Glycogen metabolism R-HSA-8982491 5.556331e-01 0.255 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.592281e-01 0.252 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.592281e-01 0.252 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.592281e-01 0.252 0 0
G protein gated Potassium channels R-HSA-1296059 5.592281e-01 0.252 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.592281e-01 0.252 0 0
HDMs demethylate histones R-HSA-3214842 5.592281e-01 0.252 0 0
Innate Immune System R-HSA-168249 5.599840e-01 0.252 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.632622e-01 0.249 0 0
Insulin receptor signalling cascade R-HSA-74751 5.709642e-01 0.243 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.711927e-01 0.243 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.711927e-01 0.243 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.711927e-01 0.243 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.711927e-01 0.243 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.711927e-01 0.243 0 0
Sodium/Calcium exchangers R-HSA-425561 5.711927e-01 0.243 0 0
Metabolism of proteins R-HSA-392499 5.720040e-01 0.243 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.791869e-01 0.237 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.840567e-01 0.234 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.840567e-01 0.234 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.840567e-01 0.234 0 0
Suppression of phagosomal maturation R-HSA-9637687 5.840567e-01 0.234 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.844092e-01 0.233 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.913149e-01 0.228 0 0
IRS activation R-HSA-74713 5.913149e-01 0.228 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.913149e-01 0.228 0 0
G2 Phase R-HSA-68911 5.913149e-01 0.228 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.913149e-01 0.228 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.913149e-01 0.228 0 0
Defective F9 activation R-HSA-9673221 5.913149e-01 0.228 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.913149e-01 0.228 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.913149e-01 0.228 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.913149e-01 0.228 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.913149e-01 0.228 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.913149e-01 0.228 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.913149e-01 0.228 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.913149e-01 0.228 0 0
Inositol transporters R-HSA-429593 5.913149e-01 0.228 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.913149e-01 0.228 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.913149e-01 0.228 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.918819e-01 0.228 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.918819e-01 0.228 0 0
Other interleukin signaling R-HSA-449836 5.918819e-01 0.228 0 0
Intra-Golgi traffic R-HSA-6811438 5.957769e-01 0.225 0 0
Translation of Structural Proteins R-HSA-9683701 5.957769e-01 0.225 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.008087e-01 0.221 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.061314e-01 0.217 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.061314e-01 0.217 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.061314e-01 0.217 0 0
Repression of WNT target genes R-HSA-4641265 6.061314e-01 0.217 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.061314e-01 0.217 0 0
Interleukin-35 Signalling R-HSA-8984722 6.061314e-01 0.217 0 0
Signaling by LTK R-HSA-9842663 6.061314e-01 0.217 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.080544e-01 0.216 0 0
PI3K Cascade R-HSA-109704 6.101378e-01 0.215 0 0
Creatine metabolism R-HSA-71288 6.192578e-01 0.208 0 0
Protein hydroxylation R-HSA-9629569 6.192578e-01 0.208 0 0
Peroxisomal protein import R-HSA-9033241 6.228960e-01 0.206 0 0
Extension of Telomeres R-HSA-180786 6.228960e-01 0.206 0 0
Leishmania phagocytosis R-HSA-9664417 6.248911e-01 0.204 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.248911e-01 0.204 0 0
Parasite infection R-HSA-9664407 6.248911e-01 0.204 0 0
Telomere Extension By Telomerase R-HSA-171319 6.311831e-01 0.200 0 0
Regulation of insulin secretion R-HSA-422356 6.353146e-01 0.197 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.388635e-01 0.195 0 0
Formation of axial mesoderm R-HSA-9796292 6.388635e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.388635e-01 0.195 0 0
Maturation of nucleoprotein R-HSA-9683610 6.388635e-01 0.195 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.403674e-01 0.194 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.403674e-01 0.194 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.403674e-01 0.194 0 0
Signaling by MAPK mutants R-HSA-9652817 6.403674e-01 0.194 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.403674e-01 0.194 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.403674e-01 0.194 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.403674e-01 0.194 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.403674e-01 0.194 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.403674e-01 0.194 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.403674e-01 0.194 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.403674e-01 0.194 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.403674e-01 0.194 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.403674e-01 0.194 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.403674e-01 0.194 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.403674e-01 0.194 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.403674e-01 0.194 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.412487e-01 0.193 0 0
RUNX2 regulates bone development R-HSA-8941326 6.420920e-01 0.192 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.453563e-01 0.190 0 0
Lagging Strand Synthesis R-HSA-69186 6.453563e-01 0.190 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.453563e-01 0.190 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.453563e-01 0.190 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.453563e-01 0.190 0 0
Ion channel transport R-HSA-983712 6.479319e-01 0.188 0 0
DAP12 interactions R-HSA-2172127 6.521552e-01 0.186 0 0
Amine ligand-binding receptors R-HSA-375280 6.521552e-01 0.186 0 0
Signaling by Erythropoietin R-HSA-9006335 6.534146e-01 0.185 0 0
mRNA Capping R-HSA-72086 6.534146e-01 0.185 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.534146e-01 0.185 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.547921e-01 0.184 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.639670e-01 0.178 0 0
Integration of energy metabolism R-HSA-163685 6.689542e-01 0.175 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.694151e-01 0.174 0 0
Removal of the Flap Intermediate R-HSA-69166 6.694151e-01 0.174 0 0
Physiological factors R-HSA-5578768 6.694151e-01 0.174 0 0
Malate-aspartate shuttle R-HSA-9856872 6.694151e-01 0.174 0 0
Zinc transporters R-HSA-435354 6.694151e-01 0.174 0 0
Signaling by PDGF R-HSA-186797 6.702623e-01 0.174 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.747295e-01 0.171 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.768049e-01 0.170 0 0
Interferon alpha/beta signaling R-HSA-909733 6.771547e-01 0.169 0 0
Leishmania infection R-HSA-9658195 6.782765e-01 0.169 0 0
Parasitic Infection Pathways R-HSA-9824443 6.782765e-01 0.169 0 0
Pyruvate metabolism R-HSA-70268 6.810068e-01 0.167 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.835348e-01 0.165 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.835348e-01 0.165 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.835348e-01 0.165 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.835348e-01 0.165 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.835348e-01 0.165 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.835348e-01 0.165 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.835348e-01 0.165 0 0
Lactose synthesis R-HSA-5653890 6.835348e-01 0.165 0 0
VLDL assembly R-HSA-8866423 6.835348e-01 0.165 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.852215e-01 0.164 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.869311e-01 0.163 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.869311e-01 0.163 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.869311e-01 0.163 0 0
Neuronal System R-HSA-112316 6.908640e-01 0.161 0 0
Notch-HLH transcription pathway R-HSA-350054 6.936672e-01 0.159 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.936672e-01 0.159 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.978382e-01 0.156 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.978382e-01 0.156 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.978382e-01 0.156 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.978382e-01 0.156 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.978382e-01 0.156 0 0
Other semaphorin interactions R-HSA-416700 6.978382e-01 0.156 0 0
Signaling by Activin R-HSA-1502540 6.978382e-01 0.156 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.987818e-01 0.156 0 0
Inositol phosphate metabolism R-HSA-1483249 7.138206e-01 0.146 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.145735e-01 0.146 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.158852e-01 0.145 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.158852e-01 0.145 0 0
Interleukin-20 family signaling R-HSA-8854691 7.158852e-01 0.145 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 7.158852e-01 0.145 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.158852e-01 0.145 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.162319e-01 0.145 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.162319e-01 0.145 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.162319e-01 0.145 0 0
Diseases of Immune System R-HSA-5260271 7.162319e-01 0.145 0 0
Neddylation R-HSA-8951664 7.190992e-01 0.143 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.215230e-01 0.142 0 0
SOS-mediated signalling R-HSA-112412 7.215230e-01 0.142 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.215230e-01 0.142 0 0
Disinhibition of SNARE formation R-HSA-114516 7.215230e-01 0.142 0 0
Mitochondrial ABC transporters R-HSA-1369007 7.215230e-01 0.142 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.215230e-01 0.142 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.215230e-01 0.142 0 0
LDL remodeling R-HSA-8964041 7.215230e-01 0.142 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.215230e-01 0.142 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.215230e-01 0.142 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.215230e-01 0.142 0 0
IRS-mediated signalling R-HSA-112399 7.232104e-01 0.141 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.242034e-01 0.140 0 0
Killing mechanisms R-HSA-9664420 7.242034e-01 0.140 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.242034e-01 0.140 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.242034e-01 0.140 0 0
Iron uptake and transport R-HSA-917937 7.319660e-01 0.136 0 0
Nuclear RNA decay R-HSA-9930044 7.331015e-01 0.135 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.331015e-01 0.135 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.331015e-01 0.135 0 0
Cardiogenesis R-HSA-9733709 7.331015e-01 0.135 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.368333e-01 0.133 0 0
Interleukin-6 family signaling R-HSA-6783589 7.368333e-01 0.133 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.368333e-01 0.133 0 0
Complex III assembly R-HSA-9865881 7.368333e-01 0.133 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.373659e-01 0.132 0 0
Kidney development R-HSA-9830369 7.406829e-01 0.130 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.485951e-01 0.126 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.485951e-01 0.126 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.485951e-01 0.126 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.489435e-01 0.126 0 0
Azathioprine ADME R-HSA-9748787 7.493470e-01 0.125 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.493470e-01 0.125 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.507096e-01 0.125 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.507096e-01 0.125 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.507096e-01 0.125 0 0
Regulation of beta-cell development R-HSA-186712 7.510075e-01 0.124 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.549530e-01 0.122 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.549530e-01 0.122 0 0
MET receptor recycling R-HSA-8875656 7.549530e-01 0.122 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.549530e-01 0.122 0 0
Regulation by c-FLIP R-HSA-3371378 7.549530e-01 0.122 0 0
Co-stimulation by ICOS R-HSA-9927354 7.549530e-01 0.122 0 0
Fructose biosynthesis R-HSA-5652227 7.549530e-01 0.122 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.549530e-01 0.122 0 0
Dimerization of procaspase-8 R-HSA-69416 7.549530e-01 0.122 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.549530e-01 0.122 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.563383e-01 0.121 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.565386e-01 0.121 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.565386e-01 0.121 0 0
Formation of the nephric duct R-HSA-9830364 7.565386e-01 0.121 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.674113e-01 0.115 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.705105e-01 0.113 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.711072e-01 0.113 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.711072e-01 0.113 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.711072e-01 0.113 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.711072e-01 0.113 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.711072e-01 0.113 0 0
Mitochondrial protein degradation R-HSA-9837999 7.733549e-01 0.112 0 0
TRP channels R-HSA-3295583 7.750347e-01 0.111 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.750347e-01 0.111 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.750347e-01 0.111 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.750347e-01 0.111 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.767540e-01 0.110 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.791184e-01 0.108 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.832239e-01 0.106 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.832239e-01 0.106 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.832239e-01 0.106 0 0
CASP8 activity is inhibited R-HSA-5218900 7.843717e-01 0.105 0 0
Calcineurin activates NFAT R-HSA-2025928 7.843717e-01 0.105 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.843717e-01 0.105 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.843717e-01 0.105 0 0
Interleukin-21 signaling R-HSA-9020958 7.843717e-01 0.105 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.843717e-01 0.105 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.843717e-01 0.105 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.843717e-01 0.105 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.843717e-01 0.105 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.843717e-01 0.105 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.843717e-01 0.105 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.843717e-01 0.105 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.888656e-01 0.103 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.918393e-01 0.101 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.918393e-01 0.101 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.918393e-01 0.101 0 0
Tie2 Signaling R-HSA-210993 7.918393e-01 0.101 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.918393e-01 0.101 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.923607e-01 0.101 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.923607e-01 0.101 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.923607e-01 0.101 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.981688e-01 0.098 0 0
SLC transporter disorders R-HSA-5619102 8.020103e-01 0.096 0 0
Post-translational protein modification R-HSA-597592 8.100937e-01 0.091 0 0
Binding and entry of HIV virion R-HSA-173107 8.102600e-01 0.091 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.102600e-01 0.091 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.102600e-01 0.091 0 0
Metabolism of serotonin R-HSA-380612 8.102600e-01 0.091 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.102600e-01 0.091 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.102600e-01 0.091 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.102600e-01 0.091 0 0
Serotonin receptors R-HSA-390666 8.102600e-01 0.091 0 0
Maturation of nucleoprotein R-HSA-9694631 8.108943e-01 0.091 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.108943e-01 0.091 0 0
IGF1R signaling cascade R-HSA-2428924 8.115946e-01 0.091 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.122699e-01 0.090 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.182780e-01 0.087 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.222275e-01 0.085 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.255538e-01 0.083 0 0
Pregnenolone biosynthesis R-HSA-196108 8.283760e-01 0.082 0 0
Signaling by NODAL R-HSA-1181150 8.283760e-01 0.082 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.330415e-01 0.079 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.330415e-01 0.079 0 0
vRNA Synthesis R-HSA-192814 8.330415e-01 0.079 0 0
vRNP Assembly R-HSA-192905 8.330415e-01 0.079 0 0
Chylomicron assembly R-HSA-8963888 8.330415e-01 0.079 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.330415e-01 0.079 0 0
LGI-ADAM interactions R-HSA-5682910 8.330415e-01 0.079 0 0
Transport of RCbl within the body R-HSA-9758890 8.330415e-01 0.079 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.330415e-01 0.079 0 0
Stimuli-sensing channels R-HSA-2672351 8.375290e-01 0.077 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.377643e-01 0.077 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.377643e-01 0.077 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.377643e-01 0.077 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.380486e-01 0.077 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.380486e-01 0.077 0 0
Adipogenesis R-HSA-9843745 8.401901e-01 0.076 0 0
NGF-stimulated transcription R-HSA-9031628 8.413172e-01 0.075 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.420772e-01 0.075 0 0
Translation of Structural Proteins R-HSA-9694635 8.484450e-01 0.071 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.508674e-01 0.070 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.530889e-01 0.069 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.530889e-01 0.069 0 0
Plasmalogen biosynthesis R-HSA-75896 8.530889e-01 0.069 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.530889e-01 0.069 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.530889e-01 0.069 0 0
Triglyceride metabolism R-HSA-8979227 8.556071e-01 0.068 0 0
Integrin cell surface interactions R-HSA-216083 8.569177e-01 0.067 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.590293e-01 0.066 0 0
Attachment and Entry R-HSA-9694614 8.590293e-01 0.066 0 0
Ribavirin ADME R-HSA-9755088 8.590293e-01 0.066 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.607913e-01 0.065 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.707301e-01 0.060 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.707301e-01 0.060 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.707301e-01 0.060 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.707301e-01 0.060 0 0
Interleukin-15 signaling R-HSA-8983432 8.707301e-01 0.060 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.707301e-01 0.060 0 0
Synthesis of GDP-mannose R-HSA-446205 8.707301e-01 0.060 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.707301e-01 0.060 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.707301e-01 0.060 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.707301e-01 0.060 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.707301e-01 0.060 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.711013e-01 0.060 0 0
The phototransduction cascade R-HSA-2514856 8.713161e-01 0.060 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.723999e-01 0.059 0 0
Cellular hexose transport R-HSA-189200 8.723999e-01 0.059 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.723999e-01 0.059 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.723999e-01 0.059 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.751161e-01 0.058 0 0
Activation of GABAB receptors R-HSA-991365 8.807460e-01 0.055 0 0
GABA B receptor activation R-HSA-977444 8.807460e-01 0.055 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.845933e-01 0.053 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.845933e-01 0.053 0 0
Formation of the ureteric bud R-HSA-9830674 8.845933e-01 0.053 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.847812e-01 0.053 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.847812e-01 0.053 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.847812e-01 0.053 0 0
Heme degradation R-HSA-189483 8.847812e-01 0.053 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.862539e-01 0.052 0 0
Processing of SMDT1 R-HSA-8949664 8.862539e-01 0.052 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.862539e-01 0.052 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.862539e-01 0.052 0 0
eNOS activation R-HSA-203615 8.944527e-01 0.048 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.999142e-01 0.046 0 0
Transport of fatty acids R-HSA-804914 8.999142e-01 0.046 0 0
Hydrolysis of LPC R-HSA-1483115 8.999142e-01 0.046 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.999142e-01 0.046 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.999142e-01 0.046 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.999142e-01 0.046 0 0
Prolactin receptor signaling R-HSA-1170546 8.999142e-01 0.046 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.999142e-01 0.046 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.999142e-01 0.046 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.999142e-01 0.046 0 0
Signaling by Insulin receptor R-HSA-74752 9.025897e-01 0.045 0 0
Paracetamol ADME R-HSA-9753281 9.037233e-01 0.044 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.058030e-01 0.043 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.058030e-01 0.043 0 0
Laminin interactions R-HSA-3000157 9.058030e-01 0.043 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.058030e-01 0.043 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.058030e-01 0.043 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.058030e-01 0.043 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.082025e-01 0.042 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.116343e-01 0.040 0 0
Erythropoietin activates RAS R-HSA-9027284 9.119347e-01 0.040 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.119347e-01 0.040 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.119347e-01 0.040 0 0
Protein lipoylation R-HSA-9857492 9.119347e-01 0.040 0 0
Transport and metabolism of PAPS R-HSA-174362 9.119347e-01 0.040 0 0
DNA Damage Reversal R-HSA-73942 9.119347e-01 0.040 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.149852e-01 0.039 0 0
MET activates PTK2 signaling R-HSA-8874081 9.149852e-01 0.039 0 0
Sphingolipid catabolism R-HSA-9845614 9.149852e-01 0.039 0 0
Urea cycle R-HSA-70635 9.149852e-01 0.039 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.158964e-01 0.038 0 0
Dectin-2 family R-HSA-5621480 9.170795e-01 0.038 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.225121e-01 0.035 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.225121e-01 0.035 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.225121e-01 0.035 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.225121e-01 0.035 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.225121e-01 0.035 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.225121e-01 0.035 0 0
Attachment and Entry R-HSA-9678110 9.225121e-01 0.035 0 0
Atorvastatin ADME R-HSA-9754706 9.225121e-01 0.035 0 0
Virus Assembly and Release R-HSA-168268 9.225121e-01 0.035 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.231236e-01 0.035 0 0
Signaling by BMP R-HSA-201451 9.233212e-01 0.035 0 0
Insulin processing R-HSA-264876 9.233212e-01 0.035 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.233212e-01 0.035 0 0
Elastic fibre formation R-HSA-1566948 9.262345e-01 0.033 0 0
Metal ion SLC transporters R-HSA-425410 9.264014e-01 0.033 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.287738e-01 0.032 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.308819e-01 0.031 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.308819e-01 0.031 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.318197e-01 0.031 0 0
Glycine degradation R-HSA-6783984 9.318197e-01 0.031 0 0
Fibronectin matrix formation R-HSA-1566977 9.318197e-01 0.031 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.318197e-01 0.031 0 0
Phase 2 - plateau phase R-HSA-5576893 9.318197e-01 0.031 0 0
Passive transport by Aquaporins R-HSA-432047 9.318197e-01 0.031 0 0
Galactose catabolism R-HSA-70370 9.318197e-01 0.031 0 0
Coenzyme A biosynthesis R-HSA-196783 9.318197e-01 0.031 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.318197e-01 0.031 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.318197e-01 0.031 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.318197e-01 0.031 0 0
tRNA Aminoacylation R-HSA-379724 9.340509e-01 0.030 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.364257e-01 0.029 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.385895e-01 0.028 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.385895e-01 0.028 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.400097e-01 0.027 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.400097e-01 0.027 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.400097e-01 0.027 0 0
Choline catabolism R-HSA-6798163 9.400097e-01 0.027 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.400097e-01 0.027 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.413727e-01 0.026 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.435662e-01 0.025 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.439365e-01 0.025 0 0
Neurotransmitter clearance R-HSA-112311 9.439365e-01 0.025 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.455387e-01 0.024 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.472163e-01 0.024 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.472163e-01 0.024 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.475009e-01 0.023 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.475009e-01 0.023 0 0
tRNA processing R-HSA-72306 9.480258e-01 0.023 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.490047e-01 0.023 0 0
HIV Transcription Initiation R-HSA-167161 9.490047e-01 0.023 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.490047e-01 0.023 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.490047e-01 0.023 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.495484e-01 0.022 0 0
Nucleotide biosynthesis R-HSA-8956320 9.516867e-01 0.022 0 0
Amino Acid conjugation R-HSA-156587 9.535576e-01 0.021 0 0
Conjugation of carboxylic acids R-HSA-159424 9.535576e-01 0.021 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.535576e-01 0.021 0 0
Diseases of hemostasis R-HSA-9671793 9.535576e-01 0.021 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.535576e-01 0.021 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.535576e-01 0.021 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.535717e-01 0.021 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.535717e-01 0.021 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.539411e-01 0.020 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.577539e-01 0.019 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.591374e-01 0.018 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.591374e-01 0.018 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.591374e-01 0.018 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.640471e-01 0.016 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.640471e-01 0.016 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.640471e-01 0.016 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.640471e-01 0.016 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.640471e-01 0.016 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.640471e-01 0.016 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.650798e-01 0.015 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.670733e-01 0.015 0 0
Hyaluronan metabolism R-HSA-2142845 9.670733e-01 0.015 0 0
RA biosynthesis pathway R-HSA-5365859 9.670733e-01 0.015 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.683671e-01 0.014 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.683671e-01 0.014 0 0
Serine metabolism R-HSA-977347 9.683671e-01 0.014 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.683671e-01 0.014 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.683671e-01 0.014 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.686980e-01 0.014 0 0
G alpha (s) signalling events R-HSA-418555 9.702201e-01 0.013 0 0
COPII-mediated vesicle transport R-HSA-204005 9.704256e-01 0.013 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.704381e-01 0.013 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.721683e-01 0.012 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.721683e-01 0.012 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.721683e-01 0.012 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.721683e-01 0.012 0 0
Fructose metabolism R-HSA-5652084 9.721683e-01 0.012 0 0
Ethanol oxidation R-HSA-71384 9.721683e-01 0.012 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.721683e-01 0.012 0 0
ECM proteoglycans R-HSA-3000178 9.727853e-01 0.012 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.734699e-01 0.012 0 0
RNA Polymerase III Transcription R-HSA-74158 9.734699e-01 0.012 0 0
RAB geranylgeranylation R-HSA-8873719 9.738444e-01 0.012 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.738444e-01 0.012 0 0
GABA receptor activation R-HSA-977443 9.738444e-01 0.012 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.755129e-01 0.011 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.755129e-01 0.011 0 0
Biosynthesis of maresins R-HSA-9018682 9.755129e-01 0.011 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.755129e-01 0.011 0 0
PI Metabolism R-HSA-1483255 9.756273e-01 0.011 0 0
Voltage gated Potassium channels R-HSA-1296072 9.762002e-01 0.010 0 0
Aspirin ADME R-HSA-9749641 9.769887e-01 0.010 0 0
CYP2E1 reactions R-HSA-211999 9.784557e-01 0.009 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.784557e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.784557e-01 0.009 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.805797e-01 0.009 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.808684e-01 0.008 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.809715e-01 0.008 0 0
Tight junction interactions R-HSA-420029 9.810450e-01 0.008 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.810450e-01 0.008 0 0
Hyaluronan degradation R-HSA-2160916 9.810450e-01 0.008 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.810450e-01 0.008 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.827635e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.829325e-01 0.007 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.833233e-01 0.007 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.833233e-01 0.007 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.833233e-01 0.007 0 0
Maturation of spike protein R-HSA-9694548 9.846426e-01 0.007 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.853278e-01 0.006 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.862423e-01 0.006 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.862475e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.885003e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.886433e-01 0.005 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.900086e-01 0.004 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.900086e-01 0.004 0 0
Methylation R-HSA-156581 9.901424e-01 0.004 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.901424e-01 0.004 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.906898e-01 0.004 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.908522e-01 0.004 0 0
Cargo concentration in the ER R-HSA-5694530 9.912099e-01 0.004 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.912625e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.914782e-01 0.004 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.920975e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.920975e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.922667e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.929525e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.931966e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.931966e-01 0.003 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.943727e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.951299e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.952938e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.953677e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.953677e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.954839e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.955111e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.957496e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.959249e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.959828e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.964150e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.964150e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.964225e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.968462e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.970350e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.972031e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.972309e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.972405e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.974827e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.974827e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.975593e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.975593e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.979879e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.983047e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.983525e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.983940e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.985385e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.986541e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.987143e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.987143e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.988690e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.988690e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.989880e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.990545e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.991249e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992147e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.992302e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992855e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.992855e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.992871e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.993229e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.993639e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.993639e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.994021e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.994044e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.994710e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.994761e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.995610e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.996434e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.997241e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.997574e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.997742e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998028e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998124e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998345e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998440e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.998548e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998877e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999012e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999012e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999029e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999320e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999328e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999380e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999543e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999557e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999574e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999598e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999598e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999646e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999708e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999726e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999836e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999856e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999889e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999889e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999899e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999953e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999958e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999970e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999978e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999978e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999980e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999982e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999983e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999986e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999989e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999989e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999990e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999991e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999993e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999994e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999995e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999996e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999996e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999996e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999998e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999999e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways