PDK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00141 S422 SIGNOR|ELM|EPSD SGK1 SGK PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00141 T256 SIGNOR|ELM|EPSD|PSP SGK1 SGK IVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDR
O14920 S181 EPSD IKBKB IKKB IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O15530 S241 SIGNOR|ELM|iPTMNet|EPSD|PSP PDPK1 PDK1 ITDFGTAKVLSPESKQARANsFVGtAQYVSPELLTEKSACK
O15530 S25 SIGNOR|ELM|EPSD|PSP PDPK1 PDK1 TSQLyDAVPIQSSVVLCSCPsPSMVRTQtESstPPGIPGGS
O15530 S393 SIGNOR|ELM|EPSD|PSP PDPK1 PDK1 yGNyDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIE
O15530 S396 SIGNOR|ELM|EPSD|PSP PDPK1 PDK1 yDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQYI
O15530 S410 SIGNOR|ELM|EPSD|PSP PDPK1 PDK1 SSSssHsLsASDTGLPQRSGsNIEQYIHDLDSNSFELDLQF
O15530 T33 iPTMNet|EPSD PDPK1 PDK1 PIQSSVVLCSCPsPSMVRTQtESstPPGIPGGSRQGPAMDG
O15530 T513 ELM|iPTMNet|EPSD|PSP PDPK1 PDK1 VLKGEIPWSQELRPEAKNFKtFFVHTPNRTYYLMDPSGNAH
O43865 S68 SIGNOR AHCYL1 DCAL IRBIT XPVKONA MQEFTKFPTKTGRRSLSRsIsQSsTDsySsAASYTDssDDE
O60331 S448 EPSD|PSP PIP5K1C KIAA0589 PSFYAERFFKFMSNTVFRKNsSLKSsPSKKGRGGALLAVKP
P00558 T243 SIGNOR|PSP PGK1 PGKA MIG10 OK/SW-cl.110 LINNMLDKVNEMIIGGGMAFtFLKVLNNMEIGTsLFDEEGA
P05106 T777 ELM|EPSD ITGB3 GP3A EEERARAKWDtANNPLyKEAtstFtNItyRGt_________
P05106 T779 SIGNOR|ELM|iPTMNet|EPSD|PSP ITGB3 GP3A ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P05771 T500 SIGNOR PRKCB PKCB PRKCB1 IKIADFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGK
P08559 S232 EPSD PDHA1 PHE1A ALWKLPCIFICENNRYGMGtsVERAAAsTDYYKRGDFIPGL
P08559 S293 EPSD|PSP PDHA1 PHE1A CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P08559 S300 EPSD PDHA1 PHE1A ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsDPIMLL
P10636 S46 EPSD MAPT MAPTL MTBT1 TAU QGGytMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDA
P10636 S515 EPSD MAPT MAPTL MTBT1 TAU APKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtP
P10636 S516 EPSD MAPT MAPTL MTBT1 TAU PKtPPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPP
P10636 S519 EPSD MAPT MAPTL MTBT1 TAU PPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTRE
P10636 S552 EPSD MAPT MAPTL MTBT1 TAU LPtPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMPDLKN
P10636 S739 EPSD MAPT MAPTL MTBT1 TAU DtsPRHLsNVsstGsIDMVDsPQLAtLADEVSASLAKQGL_
P10636 T470 EPSD MAPT MAPTL MTBT1 TAU GSSGAKEMKLKGADGKTKIAtPRGAAPPGQKGQANATRIPA
P10636 T492 EPSD MAPT MAPTL MTBT1 TAU RGAAPPGQKGQANATRIPAKtPPAPKtPPsSGEPPKsGDRs
P10636 T498 EPSD MAPT MAPTL MTBT1 TAU GQKGQANATRIPAKtPPAPKtPPsSGEPPKsGDRsGyssPG
P10636 T50 EPSD MAPT MAPTL MTBT1 TAU tMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDAKstP
P10636 T522 EPSD MAPT MAPTL MTBT1 TAU SGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKK
P10636 T529 EPSD MAPT MAPTL MTBT1 TAU GDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtP
P10636 T534 EPSD MAPT MAPTL MTBT1 TAU yssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPKsPs
P17600 S551 EPSD SYN1 RQSRPVAGGPGAPPAARPPAsPsPQRQAGPPQATRQTsVSG
P17612 T198 EPSD|PSP PRKACA PKACA QGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNK
P23443 S394 PSP RPS6KB1 STK14A QsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLGFtYV
P23443 S427 ELM|EPSD RPS6KB1 STK14A VFLGFtYVAPSVLESVKEKFsFEPKIRsPRRFIGsPRtPVs
P23443 T252 SIGNOR|ELM|iPTMNet|EPSD|PSP RPS6KB1 STK14A VKLTDFGLCKEsIHDGTVtHtFCGTIEYMAPEILMRSGHNR
P23443 T390 EPSD RPS6KB1 STK14A KPLLQsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLG
P23443 T412 SIGNOR|ELM|iPTMNet|EPSD|PSP RPS6KB1 STK14A VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P31749 S473 SIGNOR|ELM|EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 SIGNOR|ELM|EPSD|PSP AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31751 S474 SIGNOR|EPSD AKT2 DRyDsLGLLELDQRTHFPQFsysAsIRE_____________
P31751 T309 SIGNOR|ELM|EPSD|PSP AKT2 IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31946 S60 ELM YWHAB NEERNLLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQM
P36507 S226 SIGNOR|ELM|EPSD|PSP MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P51812 S227 SIGNOR RPS6KA3 ISPK1 MAPKAPK1B RSK2 IKLTDFGLSKESIDHEKKAysFCGtVEYMAPEVVNRRGHTQ
Q02156 T566 SIGNOR|ELM|iPTMNet|EPSD|PSP PRKCE PKCE CKLADFGMCKEGILNGVTTTtFCGTPDyIAPEILQELEYGP
Q02750 S222 SIGNOR|ELM|EPSD|PSP MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q04917 S59 ELM YWHAH YWHA1 NEDRNLLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKL
Q05513 T410 SIGNOR|ELM|iPTMNet|EPSD|PSP PRKCZ PKC2 IKLTDYGMCKEGLGPGDTTstFCGTPNyIAPEILRGEEyGF
Q05655 T507 SIGNOR|ELM|iPTMNet|EPSD|PSP PRKCD PKCD IKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGLKyTF
Q13153 T423 SIGNOR|ELM|iPTMNet|EPSD|PSP PAK1 VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q15118 S25 EPSD PDK1 PDHK1 RLLRGAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQ
Q15118 S393 EPSD PDK1 PDHK1 LKLYSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNt
Q15118 S396 EPSD PDK1 PDHK1 YSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHE
Q15349 S218 EPSD RPS6KA2 MAPKAPK1C RSK3 IKITDFGLSKEAIDHDKRAYsFCGtIEYMAPEVVNRRGHTQ
Q15418 S221 SIGNOR|ELM|EPSD|PSP RPS6KA1 MAPKAPK1A RSK1 IKLTDFGLSKEAIDHEKKAysFCGtVEYMAPEVVNRQGHSH
Q16512 S773 EPSD|PSP PKN1 PAK1 PKN PRK1 PRKCL1 YVKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYT
Q16512 T774 SIGNOR|ELM|EPSD|PSP PKN1 PAK1 PKN PRK1 PRKCL1 VKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTR
Q16513 T816 SIGNOR|ELM|EPSD|PSP PKN2 PRK2 PRKCL2 VKIADFGLCKEGMGYGDRtstFCGtPEFLAPEVLTETSYTR
Q16513 T951 EPSD PKN2 PRK2 PRKCL2 PPFIPTIRGREDVSNFDDEFtsEAPILtPPREPRILsEEEQ
Q96BR1 S486 SIGNOR|iPTMNet|EPSD SGK3 CISK SGKL SDYSIVNASVLEADDAFVGFsYAPPSEDLFL__________
Q96BR1 T320 SIGNOR|ELM|iPTMNet|EPSD|PSP SGK3 CISK SGKL VVLTDFGLCKEGIAISDTTTtFCGTPEYLAPEVIRKQPYDN
Q96PN8 T168 SIGNOR TSSK3 SPOGA3 STK22C KLTDFGFAKVLPKSHRELsQtFCGSTAYAAPEVLQGIPHDS
Q99683 S966 EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 KTQPKLSALSAGsNEYLRsIsLPVPVLVEDtssssEYGsVs
Q99683 T838 ELM|EPSD MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q99814 T324 EPSD|PSP EPAS1 BHLHE73 HIF2A MOP2 PASD2 SGQYRMLAKHGGYVWLETQGtVIYNPRNLQPQCIMCVNYVL
Q9HBY8 T193 SIGNOR SGK2 VVLTDFGLCKEGVEPEDTTStFCGTPEYLAPEVLRKEPYDR
Q9UBS0 S370 SIGNOR|EPSD RPS6KB2 STK14B QSEEDVSQFDTRFTRQTPVDsPDDTALSESANQAFLGFtYV
Q9UBS0 T228 SIGNOR|EPSD RPS6KB2 STK14B IKLTDFGLCKESIHEGAVTHtFCGTIEYMAPEILVRSGHNR
Q9UBS0 T388 SIGNOR|EPSD RPS6KB2 STK14B VDsPDDTALSESANQAFLGFtYVAPSVLDSIKEGFsFQPKL
Q9Y243 S120 EPSD AKT3 PKBG EAIQAVADRLQRQEEERMNCsPtsQIDNIGEEEMDAsTtHH
Q9Y243 T305 SIGNOR|ELM|EPSD|PSP AKT3 PKBG IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
L1CAM interactions R-HSA-373760 1.601388e-10 9.796 0 0
Axon guidance R-HSA-422475 4.091408e-10 9.388 0 0
Nervous system development R-HSA-9675108 4.064449e-09 8.391 0 0
Signal Transduction R-HSA-162582 1.262552e-08 7.899 1 0
Post NMDA receptor activation events R-HSA-438064 5.400929e-08 7.268 1 0
Recycling pathway of L1 R-HSA-437239 1.606325e-07 6.794 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.190533e-07 6.208 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.666050e-06 5.778 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.130998e-06 5.671 0 0
Apoptotic execution phase R-HSA-75153 4.784863e-06 5.320 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.485129e-06 5.261 1 1
Signaling by Hippo R-HSA-2028269 5.861182e-06 5.232 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.905102e-06 5.161 0 0
Mitotic Prometaphase R-HSA-68877 6.575507e-06 5.182 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.987690e-06 5.156 0 0
Cell Cycle, Mitotic R-HSA-69278 1.522709e-05 4.817 0 0
Cell Cycle R-HSA-1640170 1.728831e-05 4.762 0 0
RET signaling R-HSA-8853659 1.995422e-05 4.700 0 0
Signaling by ERBB2 R-HSA-1227986 4.481376e-05 4.349 0 0
Kinesins R-HSA-983189 4.481376e-05 4.349 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.687297e-05 4.245 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.521705e-05 4.258 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.670235e-05 4.115 1 0
Calmodulin induced events R-HSA-111933 1.131902e-04 3.946 0 0
CaM pathway R-HSA-111997 1.131902e-04 3.946 0 0
DAG and IP3 signaling R-HSA-1489509 1.112356e-04 3.954 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.229021e-04 3.910 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.211737e-04 3.917 0 0
Separation of Sister Chromatids R-HSA-2467813 1.362688e-04 3.866 0 0
DARPP-32 events R-HSA-180024 1.494234e-04 3.826 0 0
M Phase R-HSA-68886 1.498147e-04 3.824 0 0
Membrane Trafficking R-HSA-199991 1.781369e-04 3.749 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.804884e-04 3.744 0 0
FLT3 Signaling R-HSA-9607240 2.533556e-04 3.596 0 0
Mitotic Anaphase R-HSA-68882 2.494002e-04 3.603 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.607240e-04 3.584 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.644440e-04 3.578 0 0
Signaling by Interleukins R-HSA-449147 2.784003e-04 3.555 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.394404e-04 3.469 0 0
Ca-dependent events R-HSA-111996 3.398809e-04 3.469 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.648696e-04 3.438 0 0
Glycolysis R-HSA-70171 3.535733e-04 3.452 0 0
Cellular responses to stimuli R-HSA-8953897 3.587237e-04 3.445 1 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.992031e-04 3.399 0 0
Transmission across Chemical Synapses R-HSA-112315 4.332344e-04 3.363 1 0
Transport of connexons to the plasma membrane R-HSA-190872 5.031627e-04 3.298 0 0
Opioid Signalling R-HSA-111885 4.988303e-04 3.302 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.100910e-04 3.292 1 0
CREB phosphorylation R-HSA-199920 6.380813e-04 3.195 0 0
Rap1 signalling R-HSA-392517 6.270545e-04 3.203 0 0
Neuronal System R-HSA-112316 6.073881e-04 3.217 1 0
Amplification of signal from the kinetochores R-HSA-141424 8.210243e-04 3.086 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.210243e-04 3.086 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.946390e-04 3.100 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.733697e-04 3.112 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.946390e-04 3.100 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.863202e-04 3.104 0 0
Apoptosis R-HSA-109581 8.478719e-04 3.072 0 0
Semaphorin interactions R-HSA-373755 1.062345e-03 2.974 0 0
Aggrephagy R-HSA-9646399 1.021144e-03 2.991 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.069844e-03 2.971 0 0
Selective autophagy R-HSA-9663891 1.069844e-03 2.971 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.146483e-03 2.941 0 0
Signaling by VEGF R-HSA-194138 1.146886e-03 2.940 1 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.143898e-03 2.942 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.335159e-03 2.874 0 0
RSK activation R-HSA-444257 1.332646e-03 2.875 1 1
ROBO receptors bind AKAP5 R-HSA-9010642 1.332646e-03 2.875 0 0
G alpha (12/13) signalling events R-HSA-416482 1.311808e-03 2.882 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.325570e-03 2.878 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.635301e-03 2.786 1 0
Glucose metabolism R-HSA-70326 1.688672e-03 2.772 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.826081e-03 2.738 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.808909e-03 2.743 1 0
NRAGE signals death through JNK R-HSA-193648 1.876413e-03 2.727 0 0
Programmed Cell Death R-HSA-5357801 1.814477e-03 2.741 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.937394e-03 2.713 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.236354e-03 2.650 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.277452e-03 2.643 0 0
Cellular Senescence R-HSA-2559583 2.498969e-03 2.602 0 0
Regulation of beta-cell development R-HSA-186712 2.539933e-03 2.595 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.744543e-03 2.562 0 0
Cellular responses to stress R-HSA-2262752 2.846899e-03 2.546 0 0
FOXO-mediated transcription R-HSA-9614085 2.978762e-03 2.526 0 0
PLC beta mediated events R-HSA-112043 3.076988e-03 2.512 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.090159e-03 2.510 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.367434e-03 2.473 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.199104e-03 2.495 0 0
G2/M Transition R-HSA-69275 3.394155e-03 2.469 0 0
Death Receptor Signaling R-HSA-73887 3.238995e-03 2.490 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.432446e-03 2.464 1 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.442501e-03 2.463 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.746053e-03 2.426 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.101839e-03 2.387 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.835157e-03 2.416 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.811865e-03 2.419 1 0
GPCR downstream signalling R-HSA-388396 3.830321e-03 2.417 1 0
Regulation of gene expression in beta cells R-HSA-210745 4.101839e-03 2.387 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.216009e-03 2.375 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.546135e-03 2.342 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.981644e-03 2.303 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.059365e-03 2.296 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.059365e-03 2.296 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.981644e-03 2.303 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.918452e-03 2.308 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.059365e-03 2.296 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.862209e-03 2.313 0 0
G-protein mediated events R-HSA-112040 5.238942e-03 2.281 0 0
PKR-mediated signaling R-HSA-9833482 4.862209e-03 2.313 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.246222e-03 2.280 0 0
Mitotic Prophase R-HSA-68875 5.383561e-03 2.269 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.239820e-03 2.205 0 0
MHC class II antigen presentation R-HSA-2132295 6.419196e-03 2.193 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.830817e-03 2.166 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.550481e-03 2.184 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.140948e-03 2.146 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.140948e-03 2.146 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.547361e-03 2.184 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.830817e-03 2.166 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.232952e-03 2.141 0 0
Notch-HLH transcription pathway R-HSA-350054 7.235734e-03 2.141 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.368814e-03 2.133 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.549431e-03 2.122 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.679966e-03 2.115 0 0
Disinhibition of SNARE formation R-HSA-114516 9.146139e-03 2.039 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.336190e-03 2.079 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.602631e-03 2.065 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.389865e-03 2.076 1 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.336190e-03 2.079 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.119657e-03 2.040 1 1
Gap junction assembly R-HSA-190861 8.602631e-03 2.065 0 0
RAB geranylgeranylation R-HSA-8873719 9.201504e-03 2.036 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.746690e-03 2.011 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.848243e-03 2.007 0 0
Developmental Biology R-HSA-1266738 1.001330e-02 1.999 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.062408e-02 1.974 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.083707e-02 1.965 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.083707e-02 1.965 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.087452e-02 1.964 1 1
Rab regulation of trafficking R-HSA-9007101 1.112405e-02 1.954 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.180398e-02 1.928 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.274189e-02 1.895 0 0
C6 deamination of adenosine R-HSA-75102 1.274189e-02 1.895 0 0
Potassium transport channels R-HSA-1296067 1.274189e-02 1.895 0 0
IGF1R signaling cascade R-HSA-2428924 1.260027e-02 1.900 1 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.357728e-02 1.867 1 0
Vesicle-mediated transport R-HSA-5653656 1.245232e-02 1.905 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.275028e-02 1.894 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.379532e-02 1.860 1 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.379593e-02 1.860 1 1
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.389528e-02 1.857 1 1
KEAP1-NFE2L2 pathway R-HSA-9755511 1.437735e-02 1.842 0 0
Signaling by GPCR R-HSA-372790 1.468449e-02 1.833 1 0
WNT mediated activation of DVL R-HSA-201688 1.486064e-02 1.828 0 0
mRNA Editing R-HSA-75072 1.486064e-02 1.828 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.486064e-02 1.828 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.533975e-02 1.814 1 0
Interleukin-2 family signaling R-HSA-451927 1.586345e-02 1.800 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.644974e-02 1.784 0 0
Cell Cycle Checkpoints R-HSA-69620 1.652421e-02 1.782 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.683970e-02 1.774 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.738965e-02 1.760 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.738965e-02 1.760 1 1
Signaling by NOTCH3 R-HSA-9012852 1.894608e-02 1.722 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.719191e-02 1.765 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.832304e-02 1.737 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.894608e-02 1.722 0 0
G alpha (z) signalling events R-HSA-418597 1.894608e-02 1.722 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.940851e-02 1.712 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.940851e-02 1.712 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.030797e-02 1.692 0 0
MTOR signalling R-HSA-165159 2.073841e-02 1.683 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.073841e-02 1.683 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.534502e-02 1.596 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.249244e-02 1.648 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.547635e-02 1.594 0 0
ERK/MAPK targets R-HSA-198753 2.547635e-02 1.594 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.362372e-02 1.627 0 0
Synthesis of PI R-HSA-1483226 2.219505e-02 1.654 0 0
TBC/RABGAPs R-HSA-8854214 2.256606e-02 1.647 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.219505e-02 1.654 0 0
Gap junction trafficking R-HSA-190828 2.449907e-02 1.611 0 0
Hemostasis R-HSA-109582 2.531309e-02 1.597 1 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.647778e-02 1.577 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.647778e-02 1.577 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.647778e-02 1.577 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.713089e-02 1.567 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.713089e-02 1.567 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.713089e-02 1.567 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.713089e-02 1.567 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.713089e-02 1.567 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.868991e-02 1.542 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.874869e-02 1.541 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.921806e-02 1.534 0 0
IRE1alpha activates chaperones R-HSA-381070 2.989682e-02 1.524 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.095174e-02 1.509 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.101850e-02 1.508 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.116984e-02 1.506 0 0
Signaling by LTK R-HSA-9842663 3.116984e-02 1.506 0 0
RAF activation R-HSA-5673000 3.145900e-02 1.502 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.212788e-02 1.493 0 0
Intraflagellar transport R-HSA-5620924 3.332695e-02 1.477 0 0
GPER1 signaling R-HSA-9634597 3.332695e-02 1.477 0 0
Activation of AKT2 R-HSA-165158 3.592914e-02 1.445 1 1
Interleukin receptor SHC signaling R-HSA-912526 3.579984e-02 1.446 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.748721e-02 1.426 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.982622e-02 1.400 0 0
G alpha (q) signalling events R-HSA-416476 3.588239e-02 1.445 0 0
Cilium Assembly R-HSA-5617833 3.510503e-02 1.455 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.707936e-02 1.431 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.707936e-02 1.431 0 0
Autophagy R-HSA-9612973 3.650863e-02 1.438 0 0
Macroautophagy R-HSA-1632852 3.910722e-02 1.408 0 0
NrCAM interactions R-HSA-447038 3.592914e-02 1.445 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.579984e-02 1.446 1 1
Gap junction trafficking and regulation R-HSA-157858 3.581716e-02 1.446 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.626767e-02 1.440 0 0
HDL assembly R-HSA-8963896 4.176576e-02 1.379 0 0
MAPK family signaling cascades R-HSA-5683057 4.221856e-02 1.374 0 0
DNA Double Strand Break Response R-HSA-5693606 4.225848e-02 1.374 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.386446e-02 1.358 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.463861e-02 1.350 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.463861e-02 1.350 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.463861e-02 1.350 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.478497e-02 1.349 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.566292e-02 1.340 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.641740e-02 1.333 0 0
Meiosis R-HSA-1500620 4.641740e-02 1.333 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.765688e-02 1.322 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.765688e-02 1.322 0 0
Hedgehog 'off' state R-HSA-5610787 4.896905e-02 1.310 0 0
ESR-mediated signaling R-HSA-8939211 4.928663e-02 1.307 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.012407e-02 1.300 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.130125e-02 1.290 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.148024e-02 1.288 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.201081e-02 1.284 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.281369e-02 1.277 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.281369e-02 1.277 0 0
Cell junction organization R-HSA-446728 5.292886e-02 1.276 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.293815e-02 1.276 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.386277e-02 1.269 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.393227e-02 1.268 0 0
Killing mechanisms R-HSA-9664420 5.393227e-02 1.268 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.393227e-02 1.268 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.393227e-02 1.268 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.757443e-02 1.170 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.757443e-02 1.170 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.058188e-02 1.218 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.885835e-02 1.230 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.203205e-02 1.207 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.757443e-02 1.170 0 0
TNF signaling R-HSA-75893 5.657262e-02 1.247 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.882662e-02 1.230 0 0
Disorders of Developmental Biology R-HSA-9675151 6.058188e-02 1.218 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.695030e-02 1.245 0 0
Nef and signal transduction R-HSA-164944 5.624008e-02 1.250 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.270657e-02 1.203 0 0
Activation of BH3-only proteins R-HSA-114452 6.799294e-02 1.168 0 0
Interleukin-37 signaling R-HSA-9008059 6.799294e-02 1.168 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.811164e-02 1.167 0 0
Protein folding R-HSA-391251 7.093622e-02 1.149 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.173517e-02 1.144 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.183626e-02 1.144 0 0
Stimuli-sensing channels R-HSA-2672351 7.183626e-02 1.144 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.099302e-02 1.092 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 8.099302e-02 1.092 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.099302e-02 1.092 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.958547e-02 1.099 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.958547e-02 1.099 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.958547e-02 1.099 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.958547e-02 1.099 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 9.219805e-02 1.035 1 1
Lipophagy R-HSA-9613354 9.219805e-02 1.035 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.219805e-02 1.035 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.495808e-02 1.125 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.517356e-02 1.070 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.132765e-02 1.039 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.113400e-02 1.091 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.113400e-02 1.091 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.113400e-02 1.091 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.329090e-02 1.079 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.329090e-02 1.079 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 9.655706e-02 1.015 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.036525e-02 1.044 0 0
HCMV Early Events R-HSA-9609690 7.653045e-02 1.116 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.113400e-02 1.091 0 0
Co-stimulation by CD28 R-HSA-389356 9.115439e-02 1.040 1 0
Signaling by RAS mutants R-HSA-6802949 8.113400e-02 1.091 0 0
Trafficking of AMPA receptors R-HSA-399719 7.350201e-02 1.134 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.923021e-02 1.101 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.495808e-02 1.125 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.639299e-02 1.016 0 0
DNA Damage Bypass R-HSA-73893 9.639299e-02 1.016 0 0
PCP/CE pathway R-HSA-4086400 7.537815e-02 1.123 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.219805e-02 1.035 0 0
PKA activation R-HSA-163615 7.495808e-02 1.125 0 0
PKA activation in glucagon signalling R-HSA-164378 7.495808e-02 1.125 0 0
Signaling by NOTCH R-HSA-157118 8.977295e-02 1.047 0 0
Potassium Channels R-HSA-1296071 8.742219e-02 1.058 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.219805e-02 1.035 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.517356e-02 1.070 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.472595e-02 1.127 0 0
Signaling by WNT R-HSA-195721 8.615721e-02 1.065 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.958547e-02 1.099 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.219805e-02 1.035 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.699099e-02 1.061 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.693066e-02 1.014 0 0
MAP kinase activation R-HSA-450294 7.504713e-02 1.125 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.036525e-02 1.044 0 0
Reproduction R-HSA-1474165 9.481131e-02 1.023 0 0
Cell-Cell communication R-HSA-1500931 8.226417e-02 1.085 0 0
Adrenoceptors R-HSA-390696 7.958547e-02 1.099 0 0
Integrin signaling R-HSA-354192 8.517356e-02 1.070 1 1
Regulation of TP53 Activity R-HSA-5633007 7.907608e-02 1.102 1 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.517356e-02 1.070 0 0
G-protein beta:gamma signalling R-HSA-397795 8.517356e-02 1.070 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.768769e-02 1.010 0 0
Signaling by NOTCH2 R-HSA-1980145 9.768769e-02 1.010 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.811832e-02 1.008 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.902098e-02 1.004 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.902098e-02 1.004 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.902098e-02 1.004 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.189988e-01 0.924 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.189988e-01 0.924 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.189988e-01 0.924 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.189988e-01 0.924 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.189988e-01 0.924 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.189988e-01 0.924 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.189988e-01 0.924 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.554350e-01 0.808 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.554350e-01 0.808 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.554350e-01 0.808 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.554350e-01 0.808 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.554350e-01 0.808 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.554350e-01 0.808 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.554350e-01 0.808 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.053420e-01 0.977 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.053420e-01 0.977 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.053420e-01 0.977 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.189521e-01 0.925 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.329673e-01 0.876 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.329673e-01 0.876 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.329673e-01 0.876 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.473311e-01 0.832 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.473311e-01 0.832 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.473311e-01 0.832 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.473311e-01 0.832 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.076521e-01 0.968 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.351669e-01 0.869 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.351669e-01 0.869 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.351669e-01 0.869 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.179506e-01 0.928 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.323868e-01 0.878 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.398645e-01 0.854 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.475064e-01 0.831 0 0
Meiotic synapsis R-HSA-1221632 1.188153e-01 0.925 0 0
MAP2K and MAPK activation R-HSA-5674135 1.553058e-01 0.809 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.553058e-01 0.809 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.315493e-01 0.881 0 0
Centrosome maturation R-HSA-380287 1.425273e-01 0.846 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.053420e-01 0.977 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.475064e-01 0.831 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 1.179506e-01 0.928 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.053420e-01 0.977 0 0
HDMs demethylate histones R-HSA-3214842 1.448278e-01 0.839 0 0
mTORC1-mediated signalling R-HSA-166208 1.165637e-01 0.933 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.329673e-01 0.876 0 0
Signaling by FGFR1 R-HSA-5654736 1.370942e-01 0.863 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.475064e-01 0.831 0 0
Formation of the posterior neural plate R-HSA-9832991 1.189521e-01 0.925 0 0
Tight junction interactions R-HSA-420029 1.448278e-01 0.839 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.553058e-01 0.809 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.137955e-01 0.944 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.225594e-01 0.912 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.262180e-01 0.899 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.262180e-01 0.899 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.547074e-01 0.810 0 0
Regulation of CDH11 function R-HSA-9762292 1.053420e-01 0.977 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.473311e-01 0.832 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.158809e-01 0.936 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.148935e-01 0.940 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.042486e-01 0.982 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.148935e-01 0.940 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.264934e-01 0.898 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.189988e-01 0.924 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 1.554350e-01 0.808 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.554350e-01 0.808 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.189521e-01 0.925 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.264934e-01 0.898 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.272438e-01 0.895 0 0
Cellular response to heat stress R-HSA-3371556 1.225594e-01 0.912 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.100841e-01 0.958 0 0
Cellular response to chemical stress R-HSA-9711123 1.083246e-01 0.965 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.473311e-01 0.832 0 0
Disorders of Nervous System Development R-HSA-9697154 1.473311e-01 0.832 0 0
Pervasive developmental disorders R-HSA-9005895 1.473311e-01 0.832 0 0
Intra-Golgi traffic R-HSA-6811438 1.553058e-01 0.809 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.262180e-01 0.899 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.112769e-01 0.954 0 0
Signaling by NOTCH1 R-HSA-1980143 1.481697e-01 0.829 0 0
Interleukin-15 signaling R-HSA-8983432 1.473311e-01 0.832 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.189988e-01 0.924 0 0
Metalloprotease DUBs R-HSA-5689901 1.547074e-01 0.810 0 0
PECAM1 interactions R-HSA-210990 1.189521e-01 0.925 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.165637e-01 0.933 0 0
EPH-Ephrin signaling R-HSA-2682334 1.444340e-01 0.840 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.323868e-01 0.878 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.262180e-01 0.899 0 0
Interleukin-17 signaling R-HSA-448424 1.158809e-01 0.936 0 0
Immune System R-HSA-168256 1.427881e-01 0.845 1 0
Interleukin-1 family signaling R-HSA-446652 1.105514e-01 0.956 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.250800e-01 0.903 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.053420e-01 0.977 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.179506e-01 0.928 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.554350e-01 0.808 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.329673e-01 0.876 0 0
Signaling by Hedgehog R-HSA-5358351 1.255048e-01 0.901 0 0
Hyaluronan degradation R-HSA-2160916 1.448278e-01 0.839 0 0
Formation of the nephric duct R-HSA-9830364 1.448278e-01 0.839 0 0
Interleukin-7 signaling R-HSA-1266695 1.448278e-01 0.839 0 0
Interferon Signaling R-HSA-913531 1.390781e-01 0.857 0 0
TRP channels R-HSA-3295583 1.547074e-01 0.810 0 0
Interleukin-2 signaling R-HSA-9020558 1.189521e-01 0.925 0 0
Signaling by ALK R-HSA-201556 1.323868e-01 0.878 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.370942e-01 0.863 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.292155e-01 0.889 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.110048e-01 0.955 1 1
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.323868e-01 0.878 1 0
Plasma lipoprotein assembly R-HSA-8963898 1.351669e-01 0.869 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.903665e-01 0.720 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.903665e-01 0.720 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 1.903665e-01 0.720 0 0
Invadopodia formation R-HSA-8941237 1.903665e-01 0.720 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.238552e-01 0.650 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.238552e-01 0.650 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.238552e-01 0.650 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.238552e-01 0.650 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.238552e-01 0.650 0 0
Defective MAT1A causes MATD R-HSA-5579024 2.238552e-01 0.650 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.559607e-01 0.592 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.559607e-01 0.592 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.559607e-01 0.592 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.559607e-01 0.592 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.867399e-01 0.543 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.867399e-01 0.543 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.867399e-01 0.543 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.867399e-01 0.543 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.867399e-01 0.543 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.867399e-01 0.543 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.867399e-01 0.543 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.867399e-01 0.543 0 0
Formation of axial mesoderm R-HSA-9796292 1.619907e-01 0.791 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.768973e-01 0.752 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.768973e-01 0.752 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.162478e-01 0.500 0 0
STAT5 Activation R-HSA-9645135 3.162478e-01 0.500 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.920054e-01 0.717 0 0
Translesion synthesis by REV1 R-HSA-110312 1.920054e-01 0.717 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.920054e-01 0.717 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.920054e-01 0.717 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.072730e-01 0.683 0 0
Translesion synthesis by POLI R-HSA-5656121 2.072730e-01 0.683 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.226611e-01 0.652 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.226611e-01 0.652 0 0
Translesion synthesis by POLK R-HSA-5655862 2.226611e-01 0.652 0 0
Phase 2 - plateau phase R-HSA-5576893 2.226611e-01 0.652 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.226611e-01 0.652 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.647906e-01 0.783 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.381337e-01 0.623 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.381337e-01 0.623 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.855060e-01 0.732 0 0
DNA methylation R-HSA-5334118 1.855060e-01 0.732 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.961082e-01 0.708 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.961082e-01 0.708 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.068537e-01 0.684 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.068537e-01 0.684 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.847390e-01 0.546 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.177280e-01 0.662 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.287171e-01 0.641 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.002424e-01 0.523 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.156885e-01 0.501 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.156885e-01 0.501 0 0
Dual Incision in GG-NER R-HSA-5696400 2.509846e-01 0.600 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.622365e-01 0.581 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.735501e-01 0.563 0 0
Degradation of DVL R-HSA-4641258 2.849132e-01 0.545 0 0
Voltage gated Potassium channels R-HSA-1296072 2.849132e-01 0.545 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.494613e-01 0.603 0 0
mRNA 3'-end processing R-HSA-72187 2.494613e-01 0.603 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.585937e-01 0.587 0 0
snRNP Assembly R-HSA-191859 3.145050e-01 0.502 0 0
Metabolism of non-coding RNA R-HSA-194441 3.145050e-01 0.502 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.908443e-01 0.536 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.043680e-01 0.690 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.622365e-01 0.581 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.855060e-01 0.732 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.961082e-01 0.708 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.002424e-01 0.523 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.002424e-01 0.523 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.622365e-01 0.581 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.381337e-01 0.623 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.381337e-01 0.623 0 0
RUNX2 regulates bone development R-HSA-8941326 2.735501e-01 0.563 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.077406e-01 0.512 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.959648e-01 0.708 1 0
PI3K Cascade R-HSA-109704 2.314183e-01 0.636 1 0
Ephrin signaling R-HSA-3928664 2.536576e-01 0.596 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.847390e-01 0.546 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.536576e-01 0.596 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.559607e-01 0.592 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.191825e-01 0.496 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.226611e-01 0.652 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.226611e-01 0.652 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.225543e-01 0.653 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.225543e-01 0.653 0 0
Signaling by FGFR4 R-HSA-5654743 1.713493e-01 0.766 0 0
Chromatin modifying enzymes R-HSA-3247509 2.806384e-01 0.552 0 0
Signaling by FGFR3 R-HSA-5654741 1.879383e-01 0.726 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.619907e-01 0.791 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.162478e-01 0.500 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.920054e-01 0.717 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.961082e-01 0.708 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.632558e-01 0.787 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.052826e-01 0.515 0 0
HSF1-dependent transactivation R-HSA-3371571 2.404005e-01 0.619 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.920054e-01 0.717 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.849132e-01 0.545 0 0
Attenuation phase R-HSA-3371568 3.191825e-01 0.496 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.648150e-01 0.783 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.700764e-01 0.769 1 0
FGFR1 ligand binding and activation R-HSA-190242 2.536576e-01 0.596 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.632455e-01 0.787 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.632455e-01 0.787 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.632455e-01 0.787 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.632455e-01 0.787 0 0
Signaling by SCF-KIT R-HSA-1433557 1.713493e-01 0.766 0 0
IRS-mediated signalling R-HSA-112399 2.957000e-01 0.529 1 0
HCMV Infection R-HSA-9609646 1.749641e-01 0.757 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.072730e-01 0.683 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.855060e-01 0.732 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.287171e-01 0.641 0 0
Insulin receptor signalling cascade R-HSA-74751 1.912082e-01 0.718 1 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.903665e-01 0.720 0 0
PKB-mediated events R-HSA-109703 2.867399e-01 0.543 0 0
PDE3B signalling R-HSA-165160 2.867399e-01 0.543 0 0
Formation of the Editosome R-HSA-75094 2.867399e-01 0.543 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.867399e-01 0.543 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.867399e-01 0.543 0 0
Phosphorylation of Emi1 R-HSA-176417 2.867399e-01 0.543 0 0
Regulation of KIT signaling R-HSA-1433559 1.768973e-01 0.752 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.647906e-01 0.783 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.849132e-01 0.545 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.191825e-01 0.496 0 0
Signaling by NOTCH4 R-HSA-9013694 2.672750e-01 0.573 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.834320e-01 0.737 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.472154e-01 0.607 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.855159e-01 0.544 0 0
Polo-like kinase mediated events R-HSA-156711 2.536576e-01 0.596 0 0
Frs2-mediated activation R-HSA-170968 1.619907e-01 0.791 0 0
Formation of definitive endoderm R-HSA-9823730 2.847390e-01 0.546 0 0
Signalling to ERKs R-HSA-187687 2.622365e-01 0.581 0 0
Prolonged ERK activation events R-HSA-169893 2.072730e-01 0.683 0 0
S Phase R-HSA-69242 2.715243e-01 0.566 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.263333e-01 0.645 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.855523e-01 0.544 1 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.398071e-01 0.620 0 0
Meiotic recombination R-HSA-912446 2.404005e-01 0.619 0 0
G alpha (s) signalling events R-HSA-418555 1.852640e-01 0.732 0 0
FLT3 signaling in disease R-HSA-9682385 2.735501e-01 0.563 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.768973e-01 0.752 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.436992e-01 0.613 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.436992e-01 0.613 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.692021e-01 0.570 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.855060e-01 0.732 0 0
Interleukin-1 signaling R-HSA-9020702 1.988254e-01 0.702 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.848947e-01 0.733 1 1
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.840619e-01 0.735 0 0
Signaling by PTK6 R-HSA-8848021 1.840619e-01 0.735 0 0
Toll-like Receptor Cascades R-HSA-168898 2.775970e-01 0.557 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.559607e-01 0.592 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.867399e-01 0.543 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.381337e-01 0.623 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.287171e-01 0.641 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.879383e-01 0.726 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.225219e-01 0.653 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.632455e-01 0.787 0 0
Signaling by TGFBR3 R-HSA-9839373 1.964194e-01 0.707 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.867399e-01 0.543 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.622365e-01 0.581 0 0
Regulation of insulin secretion R-HSA-422356 3.145017e-01 0.502 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.034492e-01 0.692 0 0
Histamine receptors R-HSA-390650 1.903665e-01 0.720 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.162478e-01 0.500 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.287171e-01 0.641 0 0
Nuclear import of Rev protein R-HSA-180746 2.509846e-01 0.600 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.207182e-01 0.656 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.963139e-01 0.528 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.226611e-01 0.652 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.961629e-01 0.528 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.961629e-01 0.528 0 0
Cell-cell junction organization R-HSA-421270 1.783825e-01 0.749 0 0
Formation of the anterior neural plate R-HSA-9823739 1.920054e-01 0.717 0 0
Adherens junctions interactions R-HSA-418990 3.081458e-01 0.511 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.177280e-01 0.662 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.903665e-01 0.720 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.559607e-01 0.592 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.867399e-01 0.543 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.162478e-01 0.500 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.156885e-01 0.501 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.191825e-01 0.496 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.191825e-01 0.496 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.672750e-01 0.573 0 0
Netrin-1 signaling R-HSA-373752 1.795792e-01 0.746 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.795792e-01 0.746 0 0
Sensory processing of sound R-HSA-9659379 3.075665e-01 0.512 0 0
Protein methylation R-HSA-8876725 1.920054e-01 0.717 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.607588e-01 0.584 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.287171e-01 0.641 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.156885e-01 0.501 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.559607e-01 0.592 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.867399e-01 0.543 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.619907e-01 0.791 0 0
HDL clearance R-HSA-8964011 3.162478e-01 0.500 0 0
Leukotriene receptors R-HSA-391906 3.162478e-01 0.500 0 0
Synthesis of PG R-HSA-1483148 2.226611e-01 0.652 0 0
Hyaluronan metabolism R-HSA-2142845 2.509846e-01 0.600 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.963139e-01 0.528 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.539860e-01 0.595 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.501931e-01 0.602 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.879383e-01 0.726 1 0
Signaling by NTRKs R-HSA-166520 1.694556e-01 0.771 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.920054e-01 0.717 0 0
Signal transduction by L1 R-HSA-445144 2.847390e-01 0.546 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.287171e-01 0.641 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.867399e-01 0.543 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.398071e-01 0.620 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.077406e-01 0.512 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.514976e-01 0.599 0 0
Diseases of programmed cell death R-HSA-9645723 2.296313e-01 0.639 0 0
GPVI-mediated activation cascade R-HSA-114604 2.735501e-01 0.563 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 3.187320e-01 0.497 1 0
Neurofascin interactions R-HSA-447043 3.162478e-01 0.500 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.647906e-01 0.783 0 0
Tie2 Signaling R-HSA-210993 2.536576e-01 0.596 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.287171e-01 0.641 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.156885e-01 0.501 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.920013e-01 0.717 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.536576e-01 0.596 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 2.398071e-01 0.620 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.863505e-01 0.543 0 0
Triglyceride metabolism R-HSA-8979227 3.145050e-01 0.502 0 0
Triglyceride catabolism R-HSA-163560 2.735501e-01 0.563 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.768973e-01 0.752 0 0
Specification of primordial germ cells R-HSA-9827857 2.381337e-01 0.623 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.156885e-01 0.501 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.536576e-01 0.596 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.509846e-01 0.600 0 0
Gene Silencing by RNA R-HSA-211000 2.409704e-01 0.618 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.211572e-01 0.493 0 0
Integration of energy metabolism R-HSA-163685 3.211572e-01 0.493 0 0
Co-inhibition by PD-1 R-HSA-389948 3.231575e-01 0.491 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.239318e-01 0.490 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.239478e-01 0.490 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.239478e-01 0.490 0 0
Homology Directed Repair R-HSA-5693538 3.253676e-01 0.488 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.306288e-01 0.481 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.306288e-01 0.481 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.310557e-01 0.480 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.310557e-01 0.480 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.334092e-01 0.477 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.334092e-01 0.477 0 0
Aquaporin-mediated transport R-HSA-445717 3.334092e-01 0.477 0 0
Signaling by ROBO receptors R-HSA-376176 3.387101e-01 0.470 0 0
Signaling by TGFB family members R-HSA-9006936 3.399435e-01 0.469 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.420695e-01 0.466 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.420695e-01 0.466 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.420695e-01 0.466 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.428830e-01 0.465 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.428830e-01 0.465 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.439243e-01 0.464 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.445365e-01 0.463 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.445365e-01 0.463 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.445365e-01 0.463 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.445365e-01 0.463 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.445365e-01 0.463 0 0
mRNA Editing: C to U Conversion R-HSA-72200 3.445365e-01 0.463 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.445365e-01 0.463 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.445365e-01 0.463 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.445365e-01 0.463 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.445365e-01 0.463 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.445365e-01 0.463 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.445365e-01 0.463 0 0
CHL1 interactions R-HSA-447041 3.445365e-01 0.463 0 0
Adaptive Immune System R-HSA-1280218 3.461993e-01 0.461 1 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.463239e-01 0.461 0 0
Syndecan interactions R-HSA-3000170 3.463239e-01 0.461 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.486417e-01 0.458 0 0
Chromatin organization R-HSA-4839726 3.505830e-01 0.455 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.534947e-01 0.452 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.559812e-01 0.449 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.569054e-01 0.447 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.591014e-01 0.445 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.614752e-01 0.442 0 0
Neurodegenerative Diseases R-HSA-8863678 3.614752e-01 0.442 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.614752e-01 0.442 0 0
TNFs bind their physiological receptors R-HSA-5669034 3.614752e-01 0.442 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.648747e-01 0.438 0 0
Defective pyroptosis R-HSA-9710421 3.648951e-01 0.438 0 0
Neutrophil degranulation R-HSA-6798695 3.709652e-01 0.431 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.713211e-01 0.430 0 0
Type I hemidesmosome assembly R-HSA-446107 3.716566e-01 0.430 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.716566e-01 0.430 0 0
Interleukin-9 signaling R-HSA-8985947 3.716566e-01 0.430 0 0
Regulation by c-FLIP R-HSA-3371378 3.716566e-01 0.430 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.716566e-01 0.430 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.716566e-01 0.430 0 0
Dimerization of procaspase-8 R-HSA-69416 3.716566e-01 0.430 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.716566e-01 0.430 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.716566e-01 0.430 0 0
Sodium/Proton exchangers R-HSA-425986 3.716566e-01 0.430 0 0
RMTs methylate histone arginines R-HSA-3214858 3.762619e-01 0.425 0 0
Amine ligand-binding receptors R-HSA-375280 3.762619e-01 0.425 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.764932e-01 0.424 0 0
G protein gated Potassium channels R-HSA-1296059 3.764932e-01 0.424 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.764932e-01 0.424 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.764932e-01 0.424 0 0
Long-term potentiation R-HSA-9620244 3.764932e-01 0.424 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.764932e-01 0.424 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.794932e-01 0.421 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.794932e-01 0.421 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.794932e-01 0.421 0 0
G1/S Transition R-HSA-69206 3.794932e-01 0.421 0 0
Ion channel transport R-HSA-983712 3.838985e-01 0.416 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.855485e-01 0.414 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.875865e-01 0.412 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.875865e-01 0.412 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.884680e-01 0.411 0 0
Signaling by ALK in cancer R-HSA-9700206 3.884680e-01 0.411 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.913628e-01 0.407 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.913628e-01 0.407 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.913628e-01 0.407 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.913628e-01 0.407 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.913628e-01 0.407 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.913628e-01 0.407 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.921746e-01 0.407 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.976561e-01 0.400 0 0
CASP8 activity is inhibited R-HSA-5218900 3.976561e-01 0.400 0 0
ALK mutants bind TKIs R-HSA-9700645 3.976561e-01 0.400 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.976561e-01 0.400 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.976561e-01 0.400 0 0
ARMS-mediated activation R-HSA-170984 3.976561e-01 0.400 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.976561e-01 0.400 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.976561e-01 0.400 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.976561e-01 0.400 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.988609e-01 0.399 0 0
Regulated Necrosis R-HSA-5218859 3.996688e-01 0.398 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.060708e-01 0.391 0 0
Packaging Of Telomere Ends R-HSA-171306 4.060708e-01 0.391 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.060708e-01 0.391 0 0
Cristae formation R-HSA-8949613 4.060708e-01 0.391 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.060708e-01 0.391 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.060708e-01 0.391 0 0
Downstream TCR signaling R-HSA-202424 4.065050e-01 0.391 1 1
Gastrulation R-HSA-9758941 4.090882e-01 0.388 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.100775e-01 0.387 0 0
TCR signaling R-HSA-202403 4.107617e-01 0.386 1 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.206051e-01 0.376 0 0
Telomere Extension By Telomerase R-HSA-171319 4.206051e-01 0.376 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.206051e-01 0.376 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.206051e-01 0.376 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.225814e-01 0.374 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.225814e-01 0.374 0 0
Signal attenuation R-HSA-74749 4.225814e-01 0.374 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.225814e-01 0.374 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.225814e-01 0.374 0 0
Pexophagy R-HSA-9664873 4.225814e-01 0.374 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.225814e-01 0.374 0 0
Josephin domain DUBs R-HSA-5689877 4.225814e-01 0.374 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.225814e-01 0.374 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.225814e-01 0.374 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.277882e-01 0.369 0 0
Signaling by Insulin receptor R-HSA-74752 4.311554e-01 0.365 1 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.329763e-01 0.364 0 0
Late endosomal microautophagy R-HSA-9615710 4.349549e-01 0.362 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.349549e-01 0.362 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.349549e-01 0.362 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.349549e-01 0.362 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.403521e-01 0.356 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.464766e-01 0.350 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.464766e-01 0.350 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 4.464766e-01 0.350 0 0
vRNA Synthesis R-HSA-192814 4.464766e-01 0.350 0 0
Transport of RCbl within the body R-HSA-9758890 4.464766e-01 0.350 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.464766e-01 0.350 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 4.464766e-01 0.350 0 0
Suppression of apoptosis R-HSA-9635465 4.464766e-01 0.350 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.474729e-01 0.349 0 0
DAP12 signaling R-HSA-2424491 4.491106e-01 0.348 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.491106e-01 0.348 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.491106e-01 0.348 0 0
EGFR downregulation R-HSA-182971 4.630636e-01 0.334 0 0
Cargo concentration in the ER R-HSA-5694530 4.630636e-01 0.334 0 0
Neurexins and neuroligins R-HSA-6794361 4.650529e-01 0.332 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.650529e-01 0.332 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.650529e-01 0.332 0 0
Activation of RAC1 R-HSA-428540 4.693845e-01 0.328 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.693845e-01 0.328 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.693845e-01 0.328 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.693845e-01 0.328 0 0
NF-kB is activated and signals survival R-HSA-209560 4.693845e-01 0.328 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.693845e-01 0.328 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.693845e-01 0.328 0 0
Sodium/Calcium exchangers R-HSA-425561 4.693845e-01 0.328 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.693845e-01 0.328 0 0
Interleukin-12 signaling R-HSA-9020591 4.738163e-01 0.324 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.757838e-01 0.323 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.757838e-01 0.323 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.768066e-01 0.322 0 0
Mitochondrial biogenesis R-HSA-1592230 4.769100e-01 0.322 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.797219e-01 0.319 0 0
Telomere Maintenance R-HSA-157579 4.797219e-01 0.319 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.797219e-01 0.319 0 0
Signaling by FGFR R-HSA-190236 4.876877e-01 0.312 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.903330e-01 0.310 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.903330e-01 0.310 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.903330e-01 0.310 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.913456e-01 0.309 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.913456e-01 0.309 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.913456e-01 0.309 0 0
MET activates RAS signaling R-HSA-8851805 4.913456e-01 0.309 0 0
Polymerase switching R-HSA-69091 4.913456e-01 0.309 0 0
Leading Strand Synthesis R-HSA-69109 4.913456e-01 0.309 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.913456e-01 0.309 0 0
OAS antiviral response R-HSA-8983711 4.913456e-01 0.309 0 0
Interleukin-10 signaling R-HSA-6783783 4.918419e-01 0.308 0 0
HATs acetylate histones R-HSA-3214847 4.956097e-01 0.305 0 0
HDACs deacetylate histones R-HSA-3214815 4.969395e-01 0.304 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.036373e-01 0.298 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.036373e-01 0.298 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.036373e-01 0.298 0 0
Acyl chain remodelling of PC R-HSA-1482788 5.036373e-01 0.298 0 0
Asparagine N-linked glycosylation R-HSA-446203 5.045469e-01 0.297 0 0
Chromosome Maintenance R-HSA-73886 5.056444e-01 0.296 0 0
Signaling by EGFR R-HSA-177929 5.073552e-01 0.295 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.073552e-01 0.295 0 0
Ion homeostasis R-HSA-5578775 5.073552e-01 0.295 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.073552e-01 0.295 0 0
Signaling by FGFR2 R-HSA-5654738 5.096057e-01 0.293 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.123990e-01 0.290 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.123990e-01 0.290 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.123990e-01 0.290 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.123990e-01 0.290 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.123990e-01 0.290 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.123990e-01 0.290 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.123990e-01 0.290 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.123990e-01 0.290 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.123990e-01 0.290 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 5.123990e-01 0.290 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.123990e-01 0.290 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.123990e-01 0.290 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.123990e-01 0.290 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.123990e-01 0.290 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.123990e-01 0.290 0 0
Maturation of nucleoprotein R-HSA-9683610 5.123990e-01 0.290 0 0
eNOS activation R-HSA-203615 5.167146e-01 0.287 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.167146e-01 0.287 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.167146e-01 0.287 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.167146e-01 0.287 0 0
Mitophagy R-HSA-5205647 5.167146e-01 0.287 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.167146e-01 0.287 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.167146e-01 0.287 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.190898e-01 0.285 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.205041e-01 0.284 0 0
Removal of the Flap Intermediate R-HSA-69166 5.325823e-01 0.274 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.325823e-01 0.274 0 0
cGMP effects R-HSA-418457 5.325823e-01 0.274 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.325823e-01 0.274 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.325823e-01 0.274 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.325823e-01 0.274 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.325823e-01 0.274 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 5.325823e-01 0.274 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.325823e-01 0.274 0 0
Metabolism of RNA R-HSA-8953854 5.339981e-01 0.272 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.344828e-01 0.272 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.357082e-01 0.271 0 0
Extension of Telomeres R-HSA-180786 5.379068e-01 0.269 0 0
DNA Repair R-HSA-73894 5.391203e-01 0.268 0 0
G alpha (i) signalling events R-HSA-418594 5.395823e-01 0.268 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.398313e-01 0.268 0 0
Generic Transcription Pathway R-HSA-212436 5.407438e-01 0.267 1 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.421731e-01 0.266 0 0
HSF1 activation R-HSA-3371511 5.421731e-01 0.266 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.519313e-01 0.258 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.519313e-01 0.258 0 0
Erythropoietin activates RAS R-HSA-9027284 5.519313e-01 0.258 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.519313e-01 0.258 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.519313e-01 0.258 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.519313e-01 0.258 0 0
p75NTR signals via NF-kB R-HSA-193639 5.519313e-01 0.258 0 0
DCC mediated attractive signaling R-HSA-418885 5.519313e-01 0.258 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.519313e-01 0.258 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.519313e-01 0.258 0 0
Protein repair R-HSA-5676934 5.519313e-01 0.258 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.519313e-01 0.258 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.519313e-01 0.258 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.519313e-01 0.258 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.519313e-01 0.258 1 1
Protein-protein interactions at synapses R-HSA-6794362 5.527171e-01 0.257 0 0
Platelet degranulation R-HSA-114608 5.544512e-01 0.256 0 0
G2/M Checkpoints R-HSA-69481 5.544512e-01 0.256 0 0
Cleavage of the damaged purine R-HSA-110331 5.545484e-01 0.256 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.576617e-01 0.254 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.576617e-01 0.254 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.610968e-01 0.251 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.650914e-01 0.248 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.666848e-01 0.247 0 0
Depurination R-HSA-73927 5.666848e-01 0.247 0 0
Heme signaling R-HSA-9707616 5.673469e-01 0.246 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.673469e-01 0.246 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.673469e-01 0.246 0 0
tRNA processing in the nucleus R-HSA-6784531 5.673469e-01 0.246 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.673469e-01 0.246 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.704805e-01 0.244 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.704805e-01 0.244 0 0
Phosphorylation of the APC/C R-HSA-176412 5.704805e-01 0.244 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.704805e-01 0.244 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.704805e-01 0.244 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.704805e-01 0.244 0 0
Differentiation of T cells R-HSA-9945266 5.704805e-01 0.244 0 0
Negative regulation of FLT3 R-HSA-9706369 5.704805e-01 0.244 0 0
Attachment and Entry R-HSA-9678110 5.704805e-01 0.244 0 0
Interleukin-12 family signaling R-HSA-447115 5.775965e-01 0.238 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.863213e-01 0.232 0 0
Cardiac conduction R-HSA-5576891 5.879113e-01 0.231 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.882628e-01 0.230 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.882628e-01 0.230 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.882628e-01 0.230 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.882628e-01 0.230 0 0
Passive transport by Aquaporins R-HSA-432047 5.882628e-01 0.230 0 0
RNA Polymerase II Transcription R-HSA-73857 5.883701e-01 0.230 1 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.902359e-01 0.229 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.902359e-01 0.229 0 0
Diseases of Immune System R-HSA-5260271 5.902359e-01 0.229 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.902359e-01 0.229 0 0
Generation of second messenger molecules R-HSA-202433 5.902359e-01 0.229 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 5.937875e-01 0.226 0 0
Cellular response to hypoxia R-HSA-1234174 5.956066e-01 0.225 0 0
Inositol phosphate metabolism R-HSA-1483249 6.007422e-01 0.221 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.016493e-01 0.221 0 0
Maturation of spike protein R-HSA-9694548 6.016493e-01 0.221 0 0
Base Excision Repair R-HSA-73884 6.016701e-01 0.221 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.053100e-01 0.218 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.053100e-01 0.218 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.053100e-01 0.218 0 0
Choline catabolism R-HSA-6798163 6.053100e-01 0.218 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.053100e-01 0.218 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.053100e-01 0.218 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.053100e-01 0.218 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.053100e-01 0.218 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.095083e-01 0.215 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.128211e-01 0.213 0 0
Kidney development R-HSA-9830369 6.137658e-01 0.212 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.216524e-01 0.206 0 0
GAB1 signalosome R-HSA-180292 6.216524e-01 0.206 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.216524e-01 0.206 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.216524e-01 0.206 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.216524e-01 0.206 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.216524e-01 0.206 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.216524e-01 0.206 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.216524e-01 0.206 0 0
Apoptotic factor-mediated response R-HSA-111471 6.216524e-01 0.206 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.216524e-01 0.206 0 0
Mismatch Repair R-HSA-5358508 6.216524e-01 0.206 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.216524e-01 0.206 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.237517e-01 0.205 0 0
Activation of GABAB receptors R-HSA-991365 6.237517e-01 0.205 0 0
GABA B receptor activation R-HSA-977444 6.237517e-01 0.205 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.237517e-01 0.205 0 0
Depyrimidination R-HSA-73928 6.237517e-01 0.205 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.248974e-01 0.204 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.284178e-01 0.202 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.344419e-01 0.198 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.373190e-01 0.196 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.373190e-01 0.196 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.373190e-01 0.196 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.373190e-01 0.196 0 0
Regulation of signaling by CBL R-HSA-912631 6.373190e-01 0.196 0 0
Pyrimidine biosynthesis R-HSA-500753 6.373190e-01 0.196 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.373190e-01 0.196 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.373190e-01 0.196 0 0
Specification of the neural plate border R-HSA-9834899 6.373190e-01 0.196 0 0
Translesion Synthesis by POLH R-HSA-110320 6.373190e-01 0.196 0 0
Other interleukin signaling R-HSA-449836 6.373190e-01 0.196 0 0
The NLRP3 inflammasome R-HSA-844456 6.373190e-01 0.196 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.373190e-01 0.196 0 0
Maturation of nucleoprotein R-HSA-9694631 6.373190e-01 0.196 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.399585e-01 0.194 0 0
COPII-mediated vesicle transport R-HSA-204005 6.399585e-01 0.194 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.399585e-01 0.194 0 0
Cyclin D associated events in G1 R-HSA-69231 6.448930e-01 0.191 0 0
G1 Phase R-HSA-69236 6.448930e-01 0.191 0 0
DAP12 interactions R-HSA-2172127 6.448930e-01 0.191 0 0
Muscle contraction R-HSA-397014 6.453856e-01 0.190 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.484073e-01 0.188 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.523379e-01 0.186 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.523379e-01 0.186 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.523379e-01 0.186 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.523379e-01 0.186 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.523379e-01 0.186 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.523379e-01 0.186 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.523379e-01 0.186 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.523379e-01 0.186 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.523379e-01 0.186 0 0
Protein hydroxylation R-HSA-9629569 6.523379e-01 0.186 0 0
Nephrin family interactions R-HSA-373753 6.523379e-01 0.186 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.523379e-01 0.186 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.551064e-01 0.184 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.551064e-01 0.184 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.616499e-01 0.179 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.616499e-01 0.179 1 1
SLC transporter disorders R-HSA-5619102 6.644944e-01 0.178 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.650839e-01 0.177 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.667357e-01 0.176 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.667357e-01 0.176 0 0
FGFR2 ligand binding and activation R-HSA-190241 6.667357e-01 0.176 0 0
Lagging Strand Synthesis R-HSA-69186 6.667357e-01 0.176 0 0
Signalling to RAS R-HSA-167044 6.667357e-01 0.176 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.667357e-01 0.176 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.667357e-01 0.176 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.667357e-01 0.176 0 0
Basigin interactions R-HSA-210991 6.667357e-01 0.176 0 0
Signaling by FGFR in disease R-HSA-1226099 6.729019e-01 0.172 0 0
Signaling by ERBB4 R-HSA-1236394 6.729019e-01 0.172 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.770282e-01 0.169 0 0
Phospholipid metabolism R-HSA-1483257 6.789399e-01 0.168 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.805381e-01 0.167 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.805381e-01 0.167 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.805381e-01 0.167 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.805381e-01 0.167 0 0
Assembly Of The HIV Virion R-HSA-175474 6.805381e-01 0.167 0 0
Serine metabolism R-HSA-977347 6.805381e-01 0.167 0 0
Glutathione synthesis and recycling R-HSA-174403 6.805381e-01 0.167 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.805381e-01 0.167 0 0
Attachment and Entry R-HSA-9694614 6.805381e-01 0.167 0 0
Ribavirin ADME R-HSA-9755088 6.805381e-01 0.167 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.807826e-01 0.167 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.807826e-01 0.167 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.807826e-01 0.167 0 0
Metal ion SLC transporters R-HSA-425410 6.843392e-01 0.165 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.885215e-01 0.162 0 0
ABC-family proteins mediated transport R-HSA-382556 6.892397e-01 0.162 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.905248e-01 0.161 0 0
Formation of the cornified envelope R-HSA-6809371 6.923019e-01 0.160 0 0
Host Interactions of HIV factors R-HSA-162909 6.923019e-01 0.160 0 0
Degradation of CDH1 R-HSA-9766229 6.936218e-01 0.159 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.937696e-01 0.159 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.937696e-01 0.159 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.937696e-01 0.159 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.937696e-01 0.159 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.937696e-01 0.159 0 0
Signaling by KIT in disease R-HSA-9669938 6.937696e-01 0.159 0 0
Translation of Structural Proteins R-HSA-9694635 6.961188e-01 0.157 0 0
Azathioprine ADME R-HSA-9748787 7.026779e-01 0.153 0 0
ABC transporter disorders R-HSA-5619084 7.035752e-01 0.153 0 0
RNA Polymerase I Transcription R-HSA-73864 7.035752e-01 0.153 0 0
Formation of the ureteric bud R-HSA-9830674 7.064539e-01 0.151 0 0
Carnitine shuttle R-HSA-200425 7.064539e-01 0.151 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.099300e-01 0.149 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.115102e-01 0.148 0 0
The phototransduction cascade R-HSA-2514856 7.115102e-01 0.148 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.140419e-01 0.146 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.180674e-01 0.144 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.186135e-01 0.144 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.186135e-01 0.144 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.186135e-01 0.144 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.186135e-01 0.144 0 0
Deadenylation of mRNA R-HSA-429947 7.186135e-01 0.144 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.201219e-01 0.143 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.201219e-01 0.143 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.251047e-01 0.140 0 0
Amyloid fiber formation R-HSA-977225 7.251047e-01 0.140 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.285159e-01 0.138 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.285159e-01 0.138 0 0
Smooth Muscle Contraction R-HSA-445355 7.285159e-01 0.138 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.285159e-01 0.138 0 0
mRNA Splicing R-HSA-72172 7.288788e-01 0.137 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.302702e-01 0.137 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.302702e-01 0.137 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.302702e-01 0.137 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.302702e-01 0.137 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.302702e-01 0.137 0 0
TGFBR3 expression R-HSA-9839394 7.302702e-01 0.137 0 0
Alpha-oxidation of phytanate R-HSA-389599 7.302702e-01 0.137 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.302702e-01 0.137 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.366955e-01 0.133 0 0
Gene expression (Transcription) R-HSA-74160 7.376908e-01 0.132 1 0
Cytoprotection by HMOX1 R-HSA-9707564 7.387665e-01 0.131 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.414446e-01 0.130 0 0
Myogenesis R-HSA-525793 7.414446e-01 0.130 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.414446e-01 0.130 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.446642e-01 0.128 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.453929e-01 0.128 0 0
HCMV Late Events R-HSA-9610379 7.477835e-01 0.126 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.510918e-01 0.124 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.521568e-01 0.124 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.521568e-01 0.124 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.521568e-01 0.124 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.521568e-01 0.124 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.521568e-01 0.124 0 0
Triglyceride biosynthesis R-HSA-75109 7.521568e-01 0.124 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.521568e-01 0.124 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.524253e-01 0.124 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.524253e-01 0.124 0 0
Developmental Cell Lineages R-HSA-9734767 7.555762e-01 0.122 0 0
Interferon gamma signaling R-HSA-877300 7.572577e-01 0.121 0 0
Regulation of CDH1 Function R-HSA-9764561 7.599823e-01 0.119 0 0
Synthesis of PA R-HSA-1483166 7.599823e-01 0.119 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.624258e-01 0.118 0 0
HIV elongation arrest and recovery R-HSA-167287 7.624258e-01 0.118 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.624258e-01 0.118 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.624258e-01 0.118 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.624258e-01 0.118 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.624258e-01 0.118 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.624258e-01 0.118 0 0
Inflammasomes R-HSA-622312 7.624258e-01 0.118 0 0
Pyrimidine salvage R-HSA-73614 7.624258e-01 0.118 0 0
Pyroptosis R-HSA-5620971 7.624258e-01 0.118 0 0
Dual incision in TC-NER R-HSA-6782135 7.673388e-01 0.115 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.722699e-01 0.112 0 0
Thyroxine biosynthesis R-HSA-209968 7.722699e-01 0.112 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.722699e-01 0.112 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 7.722699e-01 0.112 0 0
Signaling by Erythropoietin R-HSA-9006335 7.722699e-01 0.112 0 0
Platelet calcium homeostasis R-HSA-418360 7.722699e-01 0.112 0 0
Glucagon-type ligand receptors R-HSA-420092 7.722699e-01 0.112 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.732565e-01 0.112 0 0
Peroxisomal protein import R-HSA-9033241 7.744984e-01 0.111 0 0
Innate Immune System R-HSA-168249 7.746215e-01 0.111 1 0
tRNA Aminoacylation R-HSA-379724 7.814649e-01 0.107 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.814649e-01 0.107 0 0
GABA receptor activation R-HSA-977443 7.814649e-01 0.107 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.815149e-01 0.107 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.817066e-01 0.107 0 0
Activation of the pre-replicative complex R-HSA-68962 7.817066e-01 0.107 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.817066e-01 0.107 0 0
Neurotransmitter clearance R-HSA-112311 7.817066e-01 0.107 0 0
PTEN Regulation R-HSA-6807070 7.873189e-01 0.104 0 0
Neurotransmitter release cycle R-HSA-112310 7.880791e-01 0.103 0 0
Budding and maturation of HIV virion R-HSA-162588 7.907529e-01 0.102 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.907529e-01 0.102 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.907529e-01 0.102 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 7.907529e-01 0.102 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.907529e-01 0.102 0 0
Downstream signal transduction R-HSA-186763 7.907529e-01 0.102 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.934135e-01 0.101 0 0
Mitochondrial protein import R-HSA-1268020 7.948331e-01 0.100 0 0
G0 and Early G1 R-HSA-1538133 7.994248e-01 0.097 0 0
DNA strand elongation R-HSA-69190 7.994248e-01 0.097 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.994248e-01 0.097 0 0
Signaling by WNT in cancer R-HSA-4791275 7.994248e-01 0.097 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.012423e-01 0.096 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.044709e-01 0.094 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.050033e-01 0.094 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.077379e-01 0.093 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.077379e-01 0.093 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.077379e-01 0.093 0 0
Nuclear RNA decay R-HSA-9930044 8.077379e-01 0.093 0 0
Cardiogenesis R-HSA-9733709 8.077379e-01 0.093 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.096928e-01 0.092 0 0
Mitochondrial protein degradation R-HSA-9837999 8.147965e-01 0.089 0 0
Striated Muscle Contraction R-HSA-390522 8.157069e-01 0.088 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.157069e-01 0.088 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.157069e-01 0.088 0 0
Heme degradation R-HSA-189483 8.157069e-01 0.088 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.194155e-01 0.086 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.233460e-01 0.084 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.233460e-01 0.084 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.233460e-01 0.084 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.233460e-01 0.084 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.233460e-01 0.084 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.237650e-01 0.084 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.251343e-01 0.083 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.294159e-01 0.081 1 1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.306689e-01 0.081 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.306689e-01 0.081 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.306689e-01 0.081 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 8.306689e-01 0.081 0 0
PERK regulates gene expression R-HSA-381042 8.306689e-01 0.081 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 8.306689e-01 0.081 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.360856e-01 0.078 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.376887e-01 0.077 0 0
Glycosphingolipid transport R-HSA-9845576 8.376887e-01 0.077 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.376887e-01 0.077 0 0
G1/S-Specific Transcription R-HSA-69205 8.376887e-01 0.077 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.376887e-01 0.077 0 0
RNA Polymerase III Transcription R-HSA-74158 8.376887e-01 0.077 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.413256e-01 0.075 0 0
NCAM1 interactions R-HSA-419037 8.444179e-01 0.073 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.444179e-01 0.073 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.444179e-01 0.073 0 0
Lysine catabolism R-HSA-71064 8.444179e-01 0.073 0 0
Metabolism of cofactors R-HSA-8978934 8.464134e-01 0.072 0 0
DNA Replication R-HSA-69306 8.476543e-01 0.072 0 0
Protein localization R-HSA-9609507 8.476543e-01 0.072 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.508685e-01 0.070 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.513525e-01 0.070 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.513525e-01 0.070 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.545175e-01 0.068 0 0
PI Metabolism R-HSA-1483255 8.557025e-01 0.068 0 0
Ca2+ pathway R-HSA-4086398 8.561465e-01 0.067 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.570521e-01 0.067 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.570521e-01 0.067 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.570521e-01 0.067 0 0
Pentose phosphate pathway R-HSA-71336 8.570521e-01 0.067 0 0
RAS processing R-HSA-9648002 8.570521e-01 0.067 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.570521e-01 0.067 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.570521e-01 0.067 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.607989e-01 0.065 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.607989e-01 0.065 0 0
HIV Life Cycle R-HSA-162587 8.611214e-01 0.065 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.629796e-01 0.064 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.629796e-01 0.064 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.629796e-01 0.064 0 0
HIV Transcription Elongation R-HSA-167169 8.629796e-01 0.064 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.629796e-01 0.064 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.629796e-01 0.064 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.629796e-01 0.064 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.629796e-01 0.064 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.653133e-01 0.063 0 0
Adipogenesis R-HSA-9843745 8.675558e-01 0.062 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.686617e-01 0.061 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.686617e-01 0.061 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.686617e-01 0.061 0 0
Circadian clock R-HSA-9909396 8.709074e-01 0.060 0 0
Nucleotide Excision Repair R-HSA-5696398 8.711972e-01 0.060 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.741084e-01 0.058 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.741084e-01 0.058 0 0
Translation of Structural Proteins R-HSA-9683701 8.741084e-01 0.058 0 0
Platelet homeostasis R-HSA-418346 8.748338e-01 0.058 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.780624e-01 0.056 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.818352e-01 0.055 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.820584e-01 0.055 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.820584e-01 0.055 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 8.820584e-01 0.055 0 0
Neddylation R-HSA-8951664 8.824711e-01 0.054 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.843346e-01 0.053 0 0
Leishmania infection R-HSA-9658195 8.885134e-01 0.051 0 0
Parasitic Infection Pathways R-HSA-9824443 8.885134e-01 0.051 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.891323e-01 0.051 0 0
Proteasome assembly R-HSA-9907900 8.891323e-01 0.051 0 0
Methylation R-HSA-156581 8.891323e-01 0.051 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 8.891323e-01 0.051 0 0
Nucleosome assembly R-HSA-774815 8.937312e-01 0.049 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.937312e-01 0.049 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.937312e-01 0.049 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.937312e-01 0.049 0 0
Somitogenesis R-HSA-9824272 8.937312e-01 0.049 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.937312e-01 0.049 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.937312e-01 0.049 0 0
HIV Infection R-HSA-162906 8.965445e-01 0.047 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.981396e-01 0.047 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.981396e-01 0.047 0 0
Diseases of DNA repair R-HSA-9675135 8.981396e-01 0.047 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.981396e-01 0.047 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.981396e-01 0.047 0 0
tRNA processing R-HSA-72306 9.006349e-01 0.045 0 0
Gluconeogenesis R-HSA-70263 9.064162e-01 0.043 0 0
NGF-stimulated transcription R-HSA-9031628 9.064162e-01 0.043 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.067868e-01 0.042 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.077063e-01 0.042 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.077063e-01 0.042 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.102992e-01 0.041 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.102992e-01 0.041 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.106617e-01 0.041 1 1
Signaling by FGFR2 in disease R-HSA-5655253 9.140212e-01 0.039 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.175890e-01 0.037 0 0
ER-Phagosome pathway R-HSA-1236974 9.186789e-01 0.037 0 0
Influenza Infection R-HSA-168255 9.205403e-01 0.036 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.210090e-01 0.036 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.210090e-01 0.036 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.210090e-01 0.036 0 0
Nucleotide biosynthesis R-HSA-8956320 9.242873e-01 0.034 0 0
SARS-CoV Infections R-HSA-9679506 9.260879e-01 0.033 1 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.274297e-01 0.033 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.281296e-01 0.032 0 0
Paracetamol ADME R-HSA-9753281 9.304418e-01 0.031 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.333291e-01 0.030 0 0
Collagen formation R-HSA-1474290 9.338496e-01 0.030 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.361020e-01 0.029 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.382815e-01 0.028 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.387496e-01 0.027 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.387496e-01 0.027 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.412926e-01 0.026 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.412926e-01 0.026 0 0
Glutathione conjugation R-HSA-156590 9.437301e-01 0.025 0 0
Collagen degradation R-HSA-1442490 9.460665e-01 0.024 0 0
Nucleotide salvage R-HSA-8956321 9.460665e-01 0.024 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.463141e-01 0.024 0 0
Signaling by PDGF R-HSA-186797 9.483060e-01 0.023 0 0
Selenoamino acid metabolism R-HSA-2408522 9.486004e-01 0.023 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.490274e-01 0.023 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.504527e-01 0.022 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.504527e-01 0.022 0 0
Ion transport by P-type ATPases R-HSA-936837 9.525104e-01 0.021 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.577453e-01 0.019 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.581854e-01 0.019 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.581854e-01 0.019 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.594910e-01 0.018 1 0
Transcription of the HIV genome R-HSA-167172 9.599224e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.599224e-01 0.018 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.601733e-01 0.018 0 0
Extracellular matrix organization R-HSA-1474244 9.605139e-01 0.017 0 0
Keratinization R-HSA-6805567 9.617920e-01 0.017 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.631831e-01 0.016 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.635963e-01 0.016 1 0
Hedgehog 'on' state R-HSA-5632684 9.647128e-01 0.016 0 0
Retinoid metabolism and transport R-HSA-975634 9.647128e-01 0.016 0 0
Metabolism of porphyrins R-HSA-189445 9.647128e-01 0.016 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.648569e-01 0.016 0 0
Purine catabolism R-HSA-74259 9.661790e-01 0.015 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.672770e-01 0.014 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.672770e-01 0.014 0 0
Visual phototransduction R-HSA-2187338 9.702132e-01 0.013 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.702225e-01 0.013 0 0
Protein ubiquitination R-HSA-8852135 9.702225e-01 0.013 0 0
UCH proteinases R-HSA-5689603 9.714600e-01 0.013 0 0
Interferon alpha/beta signaling R-HSA-909733 9.726459e-01 0.012 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.726462e-01 0.012 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.737832e-01 0.012 0 0
Cholesterol biosynthesis R-HSA-191273 9.737832e-01 0.012 0 0
Integrin cell surface interactions R-HSA-216083 9.737832e-01 0.012 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.746485e-01 0.011 0 0
Signaling by MET R-HSA-6806834 9.759175e-01 0.011 0 0
Post-translational protein modification R-HSA-597592 9.766338e-01 0.010 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.769186e-01 0.010 0 0
PPARA activates gene expression R-HSA-1989781 9.770010e-01 0.010 0 0
Viral Infection Pathways R-HSA-9824446 9.773533e-01 0.010 1 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.779719e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.784523e-01 0.009 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.791449e-01 0.009 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.796796e-01 0.009 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.821107e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.821107e-01 0.008 0 0
Metabolism of nucleotides R-HSA-15869 9.834608e-01 0.007 0 0
Peptide chain elongation R-HSA-156902 9.835679e-01 0.007 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.835679e-01 0.007 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.849065e-01 0.007 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.855344e-01 0.006 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.861362e-01 0.006 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.864221e-01 0.006 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.867130e-01 0.006 0 0
FCGR activation R-HSA-2029481 9.872659e-01 0.006 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.872659e-01 0.006 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.883036e-01 0.005 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.886070e-01 0.005 0 0
Eukaryotic Translation Termination R-HSA-72764 9.887904e-01 0.005 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.887904e-01 0.005 0 0
Transport of small molecules R-HSA-382551 9.892237e-01 0.005 0 0
Ribosome-associated quality control R-HSA-9948299 9.894089e-01 0.005 0 0
Deubiquitination R-HSA-5688426 9.904973e-01 0.004 0 0
Selenocysteine synthesis R-HSA-2408557 9.913143e-01 0.004 0 0
Viral mRNA Translation R-HSA-192823 9.920225e-01 0.003 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.923547e-01 0.003 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.925980e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.926730e-01 0.003 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.926730e-01 0.003 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.934456e-01 0.003 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.935509e-01 0.003 0 0
Synthesis of DNA R-HSA-69239 9.935509e-01 0.003 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.937605e-01 0.003 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.938195e-01 0.003 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.938195e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.947868e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.957861e-01 0.002 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.959617e-01 0.002 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.959617e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.961300e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.963951e-01 0.002 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.966966e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.977755e-01 0.001 0 0
rRNA processing R-HSA-72312 9.984583e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.986963e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.987219e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.987219e-01 0.001 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.987219e-01 0.001 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.987752e-01 0.001 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.988140e-01 0.001 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.989232e-01 0.000 0 0
Potential therapeutics for SARS R-HSA-9679191 9.992006e-01 0.000 0 0
Cellular response to starvation R-HSA-9711097 9.994318e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.995514e-01 0.000 0 0
Ub-specific processing proteases R-HSA-5689880 9.997131e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.997955e-01 0.000 1 0
Phase II - Conjugation of compounds R-HSA-156580 9.998028e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998355e-01 0.000 0 0
Disease R-HSA-1643685 9.998740e-01 0.000 1 0
Metabolism of proteins R-HSA-392499 9.999381e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999653e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999750e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999861e-01 0.000 0 0
Translation R-HSA-72766 9.999938e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999959e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999991e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999998e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999999e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.448042e-13 12.611 0 0
Cell Cycle, Mitotic R-HSA-69278 3.762990e-12 11.424 0 0
M Phase R-HSA-68886 2.289153e-08 7.640 0 0
Apoptotic execution phase R-HSA-75153 7.179114e-08 7.144 0 0
Mitotic Prometaphase R-HSA-68877 2.253890e-07 6.647 0 0
Regulation of TP53 Activity R-HSA-5633007 4.016462e-07 6.396 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.064890e-07 6.391 0 0
Cellular Senescence R-HSA-2559583 5.768972e-07 6.239 0 0
Cell Cycle Checkpoints R-HSA-69620 6.516571e-07 6.186 0 0
Apoptosis R-HSA-109581 1.208535e-06 5.918 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.359264e-06 5.627 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.494870e-06 5.603 0 0
Mitotic Anaphase R-HSA-68882 3.545849e-06 5.450 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.042054e-06 5.393 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.710901e-06 5.327 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.248612e-06 5.140 0 0
Separation of Sister Chromatids R-HSA-2467813 1.435115e-05 4.843 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.648759e-05 4.783 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.182421e-05 4.497 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.735055e-05 4.325 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.285333e-05 4.202 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.400018e-05 4.194 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.420312e-05 4.130 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.420312e-05 4.130 1 0
Programmed Cell Death R-HSA-5357801 7.244756e-05 4.140 0 0
Chromatin organization R-HSA-4839726 9.038372e-05 4.044 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.578753e-05 4.019 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.756837e-05 4.011 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.006262e-04 3.997 0 0
Chromatin modifying enzymes R-HSA-3247509 9.904402e-05 4.004 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.206695e-04 3.918 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.532980e-04 3.814 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.727077e-04 3.763 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.053986e-04 3.687 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.053986e-04 3.687 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.361136e-04 3.627 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.866118e-04 3.543 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.841814e-04 3.546 1 1
Membrane Trafficking R-HSA-199991 2.906671e-04 3.537 0 0
Signal Transduction R-HSA-162582 2.841214e-04 3.546 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.766540e-04 3.558 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.018877e-04 3.520 0 0
Cellular response to heat stress R-HSA-3371556 3.018877e-04 3.520 0 0
S Phase R-HSA-69242 3.337248e-04 3.477 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.728883e-04 3.428 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.675017e-04 3.435 0 0
Nervous system development R-HSA-9675108 3.822739e-04 3.418 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.338330e-04 3.363 0 0
Signaling by Hippo R-HSA-2028269 5.047248e-04 3.297 0 0
Axon guidance R-HSA-422475 4.886493e-04 3.311 0 0
MTOR signalling R-HSA-165159 5.675788e-04 3.246 0 0
p75NTR signals via NF-kB R-HSA-193639 6.071473e-04 3.217 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.695141e-04 3.174 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.067290e-04 3.151 0 0
Death Receptor Signaling R-HSA-73887 6.711144e-04 3.173 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.227806e-04 3.141 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.866274e-04 3.104 0 0
Josephin domain DUBs R-HSA-5689877 7.805458e-04 3.108 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.805458e-04 3.108 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.527908e-04 3.123 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.254677e-04 3.083 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.254677e-04 3.083 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.804952e-04 3.055 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.711826e-04 3.060 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.445863e-04 3.025 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.458866e-04 3.024 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.003647e-03 2.998 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.057209e-03 2.976 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.073509e-03 2.969 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.092002e-03 2.962 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.175521e-03 2.930 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.175743e-03 2.930 0 0
Post NMDA receptor activation events R-HSA-438064 1.275114e-03 2.894 1 0
NRAGE signals death through JNK R-HSA-193648 1.581517e-03 2.801 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.687435e-03 2.773 0 0
mRNA Splicing R-HSA-72172 1.683348e-03 2.774 0 0
Oncogene Induced Senescence R-HSA-2559585 1.687435e-03 2.773 0 0
mRNA 3'-end processing R-HSA-72187 1.763052e-03 2.754 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.789300e-03 2.747 0 0
Activation of RAC1 R-HSA-428540 1.906158e-03 2.720 0 0
NF-kB is activated and signals survival R-HSA-209560 1.906158e-03 2.720 0 0
Signaling by NOTCH1 R-HSA-1980143 1.876287e-03 2.727 0 0
Mitotic Prophase R-HSA-68875 1.819404e-03 2.740 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.906246e-03 2.720 0 0
Attenuation phase R-HSA-3371568 1.942566e-03 2.712 0 0
G2/M Transition R-HSA-69275 2.182647e-03 2.661 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.264865e-03 2.645 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.264865e-03 2.645 0 0
Semaphorin interactions R-HSA-373755 2.341071e-03 2.631 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.479442e-03 2.606 0 0
HDMs demethylate histones R-HSA-3214842 2.480984e-03 2.605 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.817463e-03 2.550 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.112504e-03 2.507 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.112504e-03 2.507 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.112504e-03 2.507 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.112504e-03 2.507 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.112504e-03 2.507 0 0
Signaling by ERBB2 R-HSA-1227986 3.112504e-03 2.507 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.260618e-03 2.487 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.304138e-03 2.481 0 0
RAF activation R-HSA-5673000 3.497392e-03 2.456 0 0
Centrosome maturation R-HSA-380287 3.319799e-03 2.479 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.432550e-03 2.464 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.523398e-03 2.453 0 0
HSF1-dependent transactivation R-HSA-3371571 3.361144e-03 2.474 0 0
Rap1 signalling R-HSA-392517 3.304138e-03 2.481 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.544578e-03 2.450 0 0
Signaling by ALK in cancer R-HSA-9700206 3.544578e-03 2.450 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.734768e-03 2.428 0 0
Regulation of PTEN localization R-HSA-8948747 3.894702e-03 2.410 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.037228e-03 2.394 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.326687e-03 2.364 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.262432e-03 2.370 1 1
Estrogen-dependent gene expression R-HSA-9018519 4.509648e-03 2.346 0 0
G2/M Checkpoints R-HSA-69481 4.383693e-03 2.358 0 0
G0 and Early G1 R-HSA-1538133 4.704380e-03 2.327 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.944683e-03 2.306 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.944683e-03 2.306 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.027174e-03 2.299 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.052500e-03 2.296 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.113484e-03 2.214 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.628495e-03 2.250 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.628495e-03 2.250 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.699276e-03 2.244 0 0
EPH-Ephrin signaling R-HSA-2682334 5.488858e-03 2.261 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.113484e-03 2.214 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.883567e-03 2.230 1 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.349777e-03 2.197 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.349777e-03 2.197 0 0
MET interacts with TNS proteins R-HSA-8875513 6.626600e-03 2.179 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.866070e-03 2.163 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.241428e-03 2.140 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.110952e-03 2.148 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.110952e-03 2.148 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.110952e-03 2.148 0 0
UCH proteinases R-HSA-5689603 7.489455e-03 2.126 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.318877e-03 2.136 0 0
MAP kinase activation R-HSA-450294 7.566679e-03 2.121 0 0
Signaling by RAS mutants R-HSA-6802949 7.110952e-03 2.148 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.566679e-03 2.121 0 0
Signaling by EGFR R-HSA-177929 7.488415e-03 2.126 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.622548e-03 2.118 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.657569e-03 2.116 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.657569e-03 2.116 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.657569e-03 2.116 1 1
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.814362e-03 2.107 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.814362e-03 2.107 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.614541e-03 2.065 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.814362e-03 2.107 0 0
Activation of BH3-only proteins R-HSA-114452 7.814362e-03 2.107 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.672544e-03 2.062 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.116125e-03 2.040 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.006360e-02 1.997 0 0
Repression of WNT target genes R-HSA-4641265 1.006360e-02 1.997 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.006360e-02 1.997 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.006360e-02 1.997 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.858432e-03 2.006 0 0
mTORC1-mediated signalling R-HSA-166208 9.272797e-03 2.033 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.543932e-03 2.020 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.543932e-03 2.020 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.028303e-02 1.988 0 0
Deubiquitination R-HSA-5688426 9.694312e-03 2.013 0 0
EGFR downregulation R-HSA-182971 9.543932e-03 2.020 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.006360e-02 1.997 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.019259e-02 1.992 0 0
Signaling by PTK6 R-HSA-8848021 9.988895e-03 2.000 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.988895e-03 2.000 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.408980e-03 2.026 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.107933e-02 1.955 0 0
CREB phosphorylation R-HSA-199920 1.107933e-02 1.955 0 0
Cyclin D associated events in G1 R-HSA-69231 1.117564e-02 1.952 0 0
G1 Phase R-HSA-69236 1.117564e-02 1.952 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.119254e-02 1.951 1 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.226967e-02 1.911 0 0
Negative regulation of MET activity R-HSA-6807004 1.255574e-02 1.901 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.255574e-02 1.901 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.309333e-02 1.883 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.361256e-02 1.866 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.388124e-02 1.858 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.453844e-02 1.837 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.444273e-02 1.840 0 0
Interleukin-17 signaling R-HSA-448424 1.278092e-02 1.893 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.374742e-02 1.862 0 0
Circadian clock R-HSA-9909396 1.301594e-02 1.886 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.275399e-02 1.894 0 0
Pexophagy R-HSA-9664873 1.309333e-02 1.883 0 0
MAP2K and MAPK activation R-HSA-5674135 1.495064e-02 1.825 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.495064e-02 1.825 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.515497e-02 1.819 0 0
Late endosomal microautophagy R-HSA-9615710 1.564941e-02 1.806 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.576664e-02 1.802 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.654548e-02 1.781 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.669255e-02 1.777 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.669255e-02 1.777 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.669255e-02 1.777 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.696804e-02 1.770 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.702463e-02 1.769 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.711570e-02 1.767 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.755325e-02 1.756 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.755325e-02 1.756 0 0
G alpha (12/13) signalling events R-HSA-416482 1.771672e-02 1.752 0 0
Selective autophagy R-HSA-9663891 1.837503e-02 1.736 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.873083e-02 1.727 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.934318e-02 1.713 1 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.954220e-02 1.709 0 0
Nuclear import of Rev protein R-HSA-180746 1.957778e-02 1.708 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.031044e-02 1.692 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.324465e-02 1.634 0 0
Ephrin signaling R-HSA-3928664 2.150984e-02 1.667 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.002475e-02 1.698 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.998421e-02 1.699 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.251673e-02 1.647 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.031044e-02 1.692 0 0
Homology Directed Repair R-HSA-5693538 2.235166e-02 1.651 0 0
Signaling by NOTCH4 R-HSA-9013694 2.046474e-02 1.689 0 0
Signaling by ROBO receptors R-HSA-376176 1.999541e-02 1.699 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.324465e-02 1.634 1 1
Regulation of beta-cell development R-HSA-186712 2.228660e-02 1.652 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.328927e-02 1.633 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.328927e-02 1.633 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.365947e-02 1.626 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.365947e-02 1.626 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.386073e-02 1.622 1 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.392968e-02 1.621 0 0
RSK activation R-HSA-444257 2.392968e-02 1.621 1 1
Myoclonic epilepsy of Lafora R-HSA-3785653 2.392968e-02 1.621 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.392968e-02 1.621 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.392968e-02 1.621 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.392968e-02 1.621 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.433007e-02 1.614 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.446547e-02 1.611 0 0
Kinesins R-HSA-983189 2.515614e-02 1.599 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.549812e-02 1.593 0 0
Metabolism of RNA R-HSA-8953854 2.575869e-02 1.589 0 0
Signaling by NOTCH3 R-HSA-9012852 2.580350e-02 1.588 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.673287e-02 1.573 0 0
DAG and IP3 signaling R-HSA-1489509 2.673840e-02 1.573 0 0
Calmodulin induced events R-HSA-111933 2.685682e-02 1.571 0 0
CaM pathway R-HSA-111997 2.685682e-02 1.571 0 0
HSF1 activation R-HSA-3371511 2.685682e-02 1.571 0 0
G1/S Transition R-HSA-69206 2.719494e-02 1.566 0 0
Signaling by VEGF R-HSA-194138 2.719494e-02 1.566 1 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.097955e-02 1.509 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.097955e-02 1.509 0 0
Phosphorylation of the APC/C R-HSA-176412 2.948705e-02 1.530 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.277662e-02 1.484 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.277662e-02 1.484 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.277662e-02 1.484 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.277662e-02 1.484 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.277662e-02 1.484 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.150633e-02 1.502 0 0
Adipogenesis R-HSA-9843745 3.013803e-02 1.521 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.053702e-02 1.515 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.942649e-02 1.531 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.097951e-02 1.509 0 0
TNF signaling R-HSA-75893 2.914908e-02 1.535 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.810191e-02 1.551 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.182074e-02 1.497 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.783823e-02 1.555 1 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.058373e-02 1.515 0 0
Cell-Cell communication R-HSA-1500931 2.957099e-02 1.529 0 0
L1CAM interactions R-HSA-373760 3.022686e-02 1.520 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.948705e-02 1.530 0 0
Negative regulation of FLT3 R-HSA-9706369 2.948705e-02 1.530 0 0
Maturation of protein E R-HSA-9694493 3.097955e-02 1.509 0 0
Maturation of protein E R-HSA-9683683 3.097955e-02 1.509 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.292797e-02 1.482 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.292797e-02 1.482 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.292797e-02 1.482 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.292797e-02 1.482 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.333529e-02 1.477 1 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.434307e-02 1.464 0 0
Recycling pathway of L1 R-HSA-437239 3.471489e-02 1.459 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.473126e-02 1.459 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.513736e-02 1.454 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.513736e-02 1.454 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.513736e-02 1.454 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.513736e-02 1.454 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.513736e-02 1.454 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.513736e-02 1.454 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.513736e-02 1.454 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.540617e-02 1.451 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.573901e-02 1.447 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.607376e-02 1.443 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.607376e-02 1.443 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.618699e-02 1.441 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.677057e-02 1.434 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.677057e-02 1.434 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.677057e-02 1.434 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.782611e-02 1.422 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.439852e-02 1.353 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.067042e-02 1.391 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.067042e-02 1.391 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.067042e-02 1.391 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.968896e-02 1.401 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.968896e-02 1.401 0 0
Metabolism of non-coding RNA R-HSA-194441 4.110787e-02 1.386 0 0
snRNP Assembly R-HSA-191859 4.110787e-02 1.386 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.572034e-02 1.340 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.110787e-02 1.386 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.186902e-02 1.378 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.378253e-02 1.359 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.142285e-02 1.383 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.272449e-02 1.369 0 0
Mitophagy R-HSA-5205647 4.172836e-02 1.380 0 0
Macroautophagy R-HSA-1632852 4.399011e-02 1.357 0 0
Co-stimulation by CD28 R-HSA-389356 3.928979e-02 1.406 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.439852e-02 1.353 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.378253e-02 1.359 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.167213e-02 1.380 0 0
Gene expression (Transcription) R-HSA-74160 4.610598e-02 1.336 1 0
Cellular responses to stimuli R-HSA-8953897 3.961338e-02 1.402 1 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.067042e-02 1.391 0 0
Inositol phosphate metabolism R-HSA-1483249 4.626852e-02 1.335 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.525262e-02 1.344 1 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.751006e-02 1.323 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.796677e-02 1.319 0 0
Metalloprotease DUBs R-HSA-5689901 4.848408e-02 1.314 0 0
Trafficking of AMPA receptors R-HSA-399719 4.853515e-02 1.314 0 0
Synthesis of DNA R-HSA-69239 4.894211e-02 1.310 0 0
Cellular responses to stress R-HSA-2262752 4.963994e-02 1.304 0 0
Cell junction organization R-HSA-446728 4.990668e-02 1.302 0 0
Rab regulation of trafficking R-HSA-9007101 5.078915e-02 1.294 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.089535e-02 1.293 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.093540e-02 1.293 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.093540e-02 1.293 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.093540e-02 1.293 0 0
Signaling by TGFB family members R-HSA-9006936 5.134061e-02 1.290 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.156659e-02 1.288 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.330159e-02 1.273 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.330159e-02 1.273 0 0
DNA Double Strand Break Response R-HSA-5693606 5.351648e-02 1.272 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.378217e-02 1.269 0 0
Polo-like kinase mediated events R-HSA-156711 5.466060e-02 1.262 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.466060e-02 1.262 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.466060e-02 1.262 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.466060e-02 1.262 0 0
RET signaling R-HSA-8853659 5.480935e-02 1.261 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.489224e-02 1.260 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.595659e-02 1.252 0 0
tRNA processing in the nucleus R-HSA-6784531 5.622910e-02 1.250 0 0
Notch-HLH transcription pathway R-HSA-350054 5.627158e-02 1.250 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.627158e-02 1.250 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.654511e-02 1.248 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.654511e-02 1.248 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.654511e-02 1.248 0 0
Autophagy R-HSA-9612973 5.783118e-02 1.238 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.790478e-02 1.237 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.790478e-02 1.237 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.886816e-02 1.230 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.886816e-02 1.230 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.886816e-02 1.230 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.017154e-02 1.221 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.058763e-02 1.218 0 0
CHL1 interactions R-HSA-447041 6.058763e-02 1.218 0 0
TCR signaling R-HSA-202403 6.131180e-02 1.212 1 0
Orc1 removal from chromatin R-HSA-68949 6.187024e-02 1.209 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.202572e-02 1.207 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.264913e-02 1.203 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.264913e-02 1.203 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.264913e-02 1.203 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.264913e-02 1.203 0 0
IKBKB deficiency causes SCID R-HSA-5602636 7.195207e-02 1.143 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 7.195207e-02 1.143 0 0
Formation of annular gap junctions R-HSA-196025 7.947842e-02 1.100 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.122510e-02 1.147 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.582216e-02 1.120 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.582216e-02 1.120 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.717935e-02 1.112 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.717935e-02 1.112 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.669686e-02 1.115 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.513603e-02 1.124 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.408638e-02 1.193 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.474749e-02 1.189 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.528264e-02 1.185 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.313318e-02 1.136 0 0
Signaling by MET R-HSA-6806834 6.323515e-02 1.199 0 0
DNA Damage Bypass R-HSA-73893 7.998537e-02 1.097 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.500021e-02 1.187 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.721240e-02 1.112 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.721240e-02 1.112 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.252062e-02 1.083 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.252062e-02 1.083 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.582216e-02 1.120 0 0
PTEN Regulation R-HSA-6807070 8.235848e-02 1.084 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.533353e-02 1.185 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.473011e-02 1.127 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.998537e-02 1.097 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.998537e-02 1.097 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.195207e-02 1.143 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.582216e-02 1.120 0 0
Developmental Biology R-HSA-1266738 7.232456e-02 1.141 0 0
Degradation of CDH1 R-HSA-9766229 7.998537e-02 1.097 0 0
Regulation of signaling by CBL R-HSA-912631 6.533353e-02 1.185 0 0
Ca-dependent events R-HSA-111996 6.760506e-02 1.170 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.529624e-02 1.185 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.252062e-02 1.083 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.252062e-02 1.083 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.947842e-02 1.100 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.910600e-02 1.102 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.420029e-02 1.075 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.252062e-02 1.083 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.947842e-02 1.100 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 8.426750e-02 1.074 0 0
IRS activation R-HSA-74713 8.426750e-02 1.074 0 0
G2 Phase R-HSA-68911 8.426750e-02 1.074 0 0
Activation of the pre-replicative complex R-HSA-68962 8.568677e-02 1.067 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.568677e-02 1.067 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.596813e-02 1.066 0 0
PLC beta mediated events R-HSA-112043 8.667936e-02 1.062 0 0
HIV Life Cycle R-HSA-162587 8.688630e-02 1.061 0 0
MAPK family signaling cascades R-HSA-5683057 8.739375e-02 1.059 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.779203e-02 1.057 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.779203e-02 1.057 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.837737e-02 1.054 0 0
Long-term potentiation R-HSA-9620244 8.837737e-02 1.054 0 0
Aggrephagy R-HSA-9646399 8.850699e-02 1.053 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.850699e-02 1.053 0 0
DNA Repair R-HSA-73894 8.873651e-02 1.052 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.044263e-02 1.044 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.044263e-02 1.044 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.131314e-02 1.039 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.185187e-02 1.037 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.194620e-02 1.036 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.194620e-02 1.036 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.337303e-02 1.030 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.445947e-02 1.025 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.469904e-02 1.024 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.707642e-02 1.013 0 0
Nucleotide Excision Repair R-HSA-5696398 9.773478e-02 1.010 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.844346e-02 1.007 0 0
FLT3 Signaling R-HSA-9607240 9.855135e-02 1.006 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.004821e-01 0.998 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.009285e-01 0.996 0 0
Lipophagy R-HSA-9613354 1.009285e-01 0.996 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.009285e-01 0.996 0 0
Gap junction degradation R-HSA-190873 1.009285e-01 0.996 0 0
WNT mediated activation of DVL R-HSA-201688 1.009285e-01 0.996 0 0
Unwinding of DNA R-HSA-176974 1.009285e-01 0.996 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.010317e-01 0.996 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.010317e-01 0.996 0 0
Signaling by NTRKs R-HSA-166520 1.031058e-01 0.987 0 0
Diseases of DNA repair R-HSA-9675135 1.031312e-01 0.987 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.035369e-01 0.985 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.035369e-01 0.985 0 0
G1/S-Specific Transcription R-HSA-69205 1.038860e-01 0.983 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.038860e-01 0.983 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.043680e-01 0.981 0 0
Vesicle-mediated transport R-HSA-5653656 1.048293e-01 0.980 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.061794e-01 0.974 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.061794e-01 0.974 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.061794e-01 0.974 0 0
Frs2-mediated activation R-HSA-170968 1.061794e-01 0.974 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.061794e-01 0.974 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.064775e-01 0.973 0 0
Specification of primordial germ cells R-HSA-9827857 1.064775e-01 0.973 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.068040e-01 0.971 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.068040e-01 0.971 0 0
Defective Base Excision Repair Associated with NEIL1 R-HSA-9616334 1.357905e-01 0.867 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.357905e-01 0.867 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.357905e-01 0.867 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.357905e-01 0.867 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.357905e-01 0.867 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.165606e-01 0.933 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.165606e-01 0.933 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.165606e-01 0.933 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.165606e-01 0.933 0 0
Diseases of cellular response to stress R-HSA-9675132 1.165606e-01 0.933 0 0
C6 deamination of adenosine R-HSA-75102 1.165606e-01 0.933 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.165606e-01 0.933 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.165606e-01 0.933 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.165606e-01 0.933 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.165606e-01 0.933 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.134953e-01 0.945 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.506592e-01 0.822 0 0
Signaling by APC mutants R-HSA-4839744 1.506592e-01 0.822 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.506592e-01 0.822 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.506592e-01 0.822 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.506592e-01 0.822 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.479974e-01 0.830 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.479974e-01 0.830 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.479974e-01 0.830 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.238743e-01 0.907 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.146446e-01 0.941 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.146446e-01 0.941 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.446405e-01 0.840 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.446405e-01 0.840 0 0
MET promotes cell motility R-HSA-8875878 1.281481e-01 0.892 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.609505e-01 0.793 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.609505e-01 0.793 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.168034e-01 0.933 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.551914e-01 0.809 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.479192e-01 0.830 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.383651e-01 0.859 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.605024e-01 0.795 0 0
Signaling by ERBB4 R-HSA-1236394 1.526285e-01 0.816 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.401005e-01 0.854 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.583252e-01 0.800 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.583252e-01 0.800 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.605024e-01 0.795 0 0
Translesion Synthesis by POLH R-HSA-110320 1.425630e-01 0.846 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.333715e-01 0.875 0 0
DARPP-32 events R-HSA-180024 1.446405e-01 0.840 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.551914e-01 0.809 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.291917e-01 0.889 0 0
Regulation of TP53 Expression R-HSA-6804754 1.165606e-01 0.933 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.320353e-01 0.879 1 1
Golgi-to-ER retrograde transport R-HSA-8856688 1.451467e-01 0.838 0 0
Regulation of KIT signaling R-HSA-1433559 1.262893e-01 0.899 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.156603e-01 0.937 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.258207e-01 0.900 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.168034e-01 0.933 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.446405e-01 0.840 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.223377e-01 0.912 0 0
Stabilization of p53 R-HSA-69541 1.413323e-01 0.850 0 0
TBC/RABGAPs R-HSA-8854214 1.325505e-01 0.878 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.181365e-01 0.928 1 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.247369e-01 0.904 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.262893e-01 0.899 0 0
Signaling by NOTCH2 R-HSA-1980145 1.507847e-01 0.822 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.238743e-01 0.907 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.223377e-01 0.912 0 0
ESR-mediated signaling R-HSA-8939211 1.262140e-01 0.899 1 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.325505e-01 0.878 0 0
NGF-stimulated transcription R-HSA-9031628 1.243905e-01 0.905 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.413323e-01 0.850 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.360497e-01 0.866 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.401907e-01 0.853 0 0
G-protein mediated events R-HSA-112040 1.414852e-01 0.849 0 0
Host Interactions of HIV factors R-HSA-162909 1.175299e-01 0.930 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.223377e-01 0.912 0 0
Heme signaling R-HSA-9707616 1.512782e-01 0.820 0 0
PECAM1 interactions R-HSA-210990 1.506592e-01 0.822 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.521525e-01 0.818 0 0
Signaling by Leptin R-HSA-2586552 1.247369e-01 0.904 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.196662e-01 0.922 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.196662e-01 0.922 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.281481e-01 0.892 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.146446e-01 0.941 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.534660e-01 0.814 0 0
Neurodegenerative Diseases R-HSA-8863678 1.534660e-01 0.814 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.205815e-01 0.919 0 0
Regulation of CDH1 Function R-HSA-9764561 1.619463e-01 0.791 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.624583e-01 0.789 0 0
Signal transduction by L1 R-HSA-445144 1.624583e-01 0.789 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.625964e-01 0.789 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.628184e-01 0.788 0 0
Regulation of Apoptosis R-HSA-169911 1.661334e-01 0.780 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.661334e-01 0.780 0 0
MET activates STAT3 R-HSA-8875791 1.661693e-01 0.779 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.661693e-01 0.779 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.661693e-01 0.779 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.661693e-01 0.779 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.670983e-01 0.777 0 0
Cell-cell junction organization R-HSA-421270 1.691487e-01 0.772 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.696993e-01 0.770 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.696993e-01 0.770 1 1
RNA Polymerase II Transcription R-HSA-73857 1.705796e-01 0.768 1 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.711579e-01 0.767 0 0
Prolonged ERK activation events R-HSA-169893 1.711579e-01 0.767 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.711579e-01 0.767 0 0
TGFBR3 expression R-HSA-9839394 1.718530e-01 0.765 0 0
Tight junction interactions R-HSA-420029 1.718530e-01 0.765 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.718530e-01 0.765 1 1
DNA Replication Pre-Initiation R-HSA-69002 1.773659e-01 0.751 0 0
Downstream signal transduction R-HSA-186763 1.780741e-01 0.749 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.780741e-01 0.749 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.780741e-01 0.749 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.784213e-01 0.749 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.784213e-01 0.749 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.784213e-01 0.749 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.784213e-01 0.749 0 0
Signaling by AXIN mutants R-HSA-4839735 1.784213e-01 0.749 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.790092e-01 0.747 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.805839e-01 0.743 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.805839e-01 0.743 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.805839e-01 0.743 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.809802e-01 0.742 0 0
PTK6 Expression R-HSA-8849473 1.809802e-01 0.742 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.809802e-01 0.742 0 0
Disinhibition of SNARE formation R-HSA-114516 1.809802e-01 0.742 0 0
ERK/MAPK targets R-HSA-198753 1.834624e-01 0.736 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.848257e-01 0.733 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.848257e-01 0.733 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.852390e-01 0.732 0 0
Cellular response to hypoxia R-HSA-1234174 1.872026e-01 0.728 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.872026e-01 0.728 0 0
FOXO-mediated transcription R-HSA-9614085 1.907541e-01 0.720 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.947007e-01 0.711 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.947007e-01 0.711 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.956091e-01 0.709 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.956091e-01 0.709 0 0
Disorders of Developmental Biology R-HSA-9675151 1.956091e-01 0.709 0 0
PCP/CE pathway R-HSA-4086400 1.975411e-01 0.704 0 0
Degradation of DVL R-HSA-4641258 1.988945e-01 0.701 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.000150e-01 0.699 0 0
Glycolysis R-HSA-70171 2.012031e-01 0.696 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.012570e-01 0.696 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.012570e-01 0.696 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.054668e-01 0.687 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.054668e-01 0.687 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.076662e-01 0.683 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.077316e-01 0.682 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.077316e-01 0.682 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.077316e-01 0.682 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.077316e-01 0.682 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.077316e-01 0.682 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.077316e-01 0.682 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.077316e-01 0.682 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.077316e-01 0.682 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.090790e-01 0.680 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.096593e-01 0.678 0 0
Sensory processing of sound R-HSA-9659379 2.096593e-01 0.678 0 0
MHC class II antigen presentation R-HSA-2132295 2.111907e-01 0.675 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.112482e-01 0.675 1 1
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.112482e-01 0.675 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.531487e-01 0.597 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.531487e-01 0.597 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.531487e-01 0.597 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.531487e-01 0.597 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.531487e-01 0.597 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.531487e-01 0.597 0 0
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) R-HSA-5619088 2.531487e-01 0.597 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.531487e-01 0.597 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.531487e-01 0.597 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.531487e-01 0.597 0 0
Regulation of gap junction activity R-HSA-191650 2.185989e-01 0.660 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.185989e-01 0.660 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.185989e-01 0.660 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.185989e-01 0.660 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.545757e-01 0.450 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.545757e-01 0.450 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.545757e-01 0.450 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.545757e-01 0.450 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.545757e-01 0.450 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.545757e-01 0.450 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.545757e-01 0.450 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 3.545757e-01 0.450 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.545757e-01 0.450 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.545757e-01 0.450 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.545757e-01 0.450 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.545757e-01 0.450 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.545757e-01 0.450 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.545757e-01 0.450 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.545757e-01 0.450 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.545757e-01 0.450 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.721696e-01 0.565 0 0
Activation of AKT2 R-HSA-165158 2.721696e-01 0.565 1 1
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.721696e-01 0.565 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.721696e-01 0.565 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.721696e-01 0.565 0 0
Type I hemidesmosome assembly R-HSA-446107 2.179748e-01 0.662 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.256052e-01 0.487 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.256052e-01 0.487 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.256052e-01 0.487 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.955023e-01 0.529 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.211781e-01 0.655 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.698041e-01 0.569 0 0
Signaling by LTK in cancer R-HSA-9842640 3.779549e-01 0.423 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.779549e-01 0.423 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.779549e-01 0.423 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.476852e-01 0.606 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 3.349921e-01 0.475 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.019819e-01 0.520 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.019819e-01 0.520 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.019819e-01 0.520 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.019819e-01 0.520 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.145419e-01 0.668 1 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.535898e-01 0.596 0 0
Deadenylation of mRNA R-HSA-429947 2.762956e-01 0.559 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.762956e-01 0.559 0 0
Translesion synthesis by POLI R-HSA-5656121 3.345514e-01 0.476 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.345514e-01 0.476 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.743677e-01 0.427 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.285286e-01 0.368 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.285286e-01 0.368 0 0
SOS-mediated signalling R-HSA-112412 4.285286e-01 0.368 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.285286e-01 0.368 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 4.285286e-01 0.368 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.672577e-01 0.435 0 0
Translesion synthesis by POLK R-HSA-5655862 3.672577e-01 0.435 0 0
MET activates PTK2 signaling R-HSA-8874081 3.262839e-01 0.486 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.132564e-01 0.384 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.132564e-01 0.384 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.684361e-01 0.571 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.652499e-01 0.576 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.618986e-01 0.582 0 0
Degradation of AXIN R-HSA-4641257 3.156353e-01 0.501 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.517351e-01 0.454 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.517351e-01 0.454 0 0
Meiotic synapsis R-HSA-1221632 2.822195e-01 0.549 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.101922e-01 0.508 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.880122e-01 0.411 0 0
Translation initiation complex formation R-HSA-72649 2.994996e-01 0.524 0 0
HIV elongation arrest and recovery R-HSA-167287 3.773311e-01 0.423 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.773311e-01 0.423 0 0
Striated Muscle Contraction R-HSA-390522 3.675703e-01 0.435 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.348271e-01 0.475 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.029581e-01 0.395 0 0
Dual Incision in GG-NER R-HSA-5696400 3.910205e-01 0.408 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.703983e-01 0.431 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.285083e-01 0.368 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.369894e-01 0.472 0 0
Downstream TCR signaling R-HSA-202424 2.835449e-01 0.547 1 1
Regulation of necroptotic cell death R-HSA-5675482 2.145419e-01 0.668 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.525026e-01 0.598 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.525026e-01 0.598 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.126547e-01 0.505 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.126547e-01 0.505 0 0
Integrin signaling R-HSA-354192 2.145419e-01 0.668 1 1
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.126547e-01 0.505 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.802516e-01 0.420 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.743677e-01 0.427 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.132564e-01 0.384 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.382914e-01 0.623 0 0
DNA strand elongation R-HSA-69190 3.210503e-01 0.493 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.320943e-01 0.634 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.535898e-01 0.596 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.507885e-01 0.601 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.501485e-01 0.456 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.910205e-01 0.408 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.703983e-01 0.431 1 0
DCC mediated attractive signaling R-HSA-418885 3.019819e-01 0.520 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.738445e-01 0.562 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.713545e-01 0.566 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.289106e-01 0.640 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.957813e-01 0.403 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.202180e-01 0.377 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.307856e-01 0.637 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.179748e-01 0.662 0 0
PI3K/AKT activation R-HSA-198203 2.955023e-01 0.529 0 0
Translesion synthesis by REV1 R-HSA-110312 3.019819e-01 0.520 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.285286e-01 0.368 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.998672e-01 0.398 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.549501e-01 0.594 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.442172e-01 0.463 0 0
DNA Replication R-HSA-69306 2.958595e-01 0.529 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.111515e-01 0.386 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.418691e-01 0.616 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.721696e-01 0.565 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.563320e-01 0.591 0 0
Formation of axial mesoderm R-HSA-9796292 2.382914e-01 0.623 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.285286e-01 0.368 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.672577e-01 0.435 0 0
Signaling by WNT in cancer R-HSA-4791275 3.210503e-01 0.493 0 0
Signaling by WNT R-HSA-195721 2.220022e-01 0.654 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.382041e-01 0.471 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.382041e-01 0.471 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.118541e-01 0.506 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.179748e-01 0.662 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.779549e-01 0.423 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.310210e-01 0.480 0 0
Generation of second messenger molecules R-HSA-202433 2.525026e-01 0.598 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.164555e-01 0.380 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.491624e-01 0.604 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.882760e-01 0.540 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.713545e-01 0.566 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.185989e-01 0.660 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.721696e-01 0.565 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.563320e-01 0.591 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.211781e-01 0.655 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.196247e-01 0.658 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.675703e-01 0.435 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.020181e-01 0.396 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.020181e-01 0.396 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.144821e-01 0.382 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.536756e-01 0.451 1 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.145419e-01 0.668 0 0
Signaling by SCF-KIT R-HSA-1433557 3.300602e-01 0.481 0 0
Meiosis R-HSA-1500620 2.886453e-01 0.540 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.185989e-01 0.660 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.256052e-01 0.487 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.256052e-01 0.487 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.955023e-01 0.529 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.743677e-01 0.427 0 0
G-protein beta:gamma signalling R-HSA-397795 3.442172e-01 0.463 1 0
Nuclear RNA decay R-HSA-9930044 3.442172e-01 0.463 0 0
HDACs deacetylate histones R-HSA-3214815 3.170493e-01 0.499 0 0
HIV Infection R-HSA-162906 2.750035e-01 0.561 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.563320e-01 0.591 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.955023e-01 0.529 0 0
Signal attenuation R-HSA-74749 2.955023e-01 0.529 0 0
Neurofascin interactions R-HSA-447043 3.779549e-01 0.423 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.749481e-01 0.561 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.285286e-01 0.368 0 0
Cellular response to chemical stress R-HSA-9711123 2.392037e-01 0.621 0 0
Glycogen synthesis R-HSA-3322077 3.027858e-01 0.519 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.957813e-01 0.403 1 1
Signaling by ALK R-HSA-201556 3.585521e-01 0.445 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.804862e-01 0.552 0 0
Adherens junctions interactions R-HSA-418990 2.545360e-01 0.594 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.185989e-01 0.660 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.545757e-01 0.450 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.545757e-01 0.450 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.545757e-01 0.450 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.545757e-01 0.450 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.545757e-01 0.450 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 2.721696e-01 0.565 0 0
Signaling by LTK R-HSA-9842663 4.132564e-01 0.384 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.549501e-01 0.594 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.233842e-01 0.490 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.172958e-01 0.499 0 0
Neurexins and neuroligins R-HSA-6794361 3.804367e-01 0.420 0 0
Netrin-1 signaling R-HSA-373752 3.501485e-01 0.456 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.904987e-01 0.537 1 0
Opioid Signalling R-HSA-111885 3.250144e-01 0.488 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.038260e-01 0.517 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.157588e-01 0.501 1 0
Signalling to ERKs R-HSA-187687 4.144821e-01 0.382 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.320943e-01 0.634 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.594837e-01 0.444 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.256797e-01 0.371 0 0
Glycogen storage diseases R-HSA-3229121 2.211781e-01 0.655 0 0
Nef and signal transduction R-HSA-164944 3.779549e-01 0.423 0 0
Pervasive developmental disorders R-HSA-9005895 4.132564e-01 0.384 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.132564e-01 0.384 0 0
Disorders of Nervous System Development R-HSA-9697154 4.132564e-01 0.384 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.675703e-01 0.435 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.910205e-01 0.408 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.910205e-01 0.408 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.703983e-01 0.431 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.868100e-01 0.413 0 0
Nephrin family interactions R-HSA-373753 3.027858e-01 0.519 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.101200e-01 0.387 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.545757e-01 0.450 0 0
Synthesis of PI R-HSA-1483226 3.349921e-01 0.475 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.145419e-01 0.668 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.880122e-01 0.411 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.442172e-01 0.463 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.310210e-01 0.480 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.170883e-01 0.663 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.883814e-01 0.411 0 0
Syndecan interactions R-HSA-3000170 4.164555e-01 0.380 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.721696e-01 0.565 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.285286e-01 0.368 0 0
Assembly Of The HIV Virion R-HSA-175474 3.594837e-01 0.444 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.348271e-01 0.475 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.620125e-01 0.441 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.262839e-01 0.486 0 0
HDL assembly R-HSA-8963896 2.698041e-01 0.569 0 0
Stimuli-sensing channels R-HSA-2672351 3.920357e-01 0.407 0 0
Growth hormone receptor signaling R-HSA-982772 4.164555e-01 0.380 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.019992e-01 0.396 1 0
SARS-CoV-1 Infection R-HSA-9678108 3.302644e-01 0.481 1 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.256052e-01 0.487 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.672577e-01 0.435 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.349921e-01 0.475 0 0
Regulation of BACH1 activity R-HSA-9708530 3.345514e-01 0.476 0 0
Interleukin-12 signaling R-HSA-9020591 3.458229e-01 0.461 0 0
Interleukin-12 family signaling R-HSA-447115 4.306060e-01 0.366 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.316329e-01 0.365 0 0
PKA activation R-HSA-163615 4.321693e-01 0.364 0 0
PKA activation in glucagon signalling R-HSA-164378 4.321693e-01 0.364 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.321693e-01 0.364 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.369491e-01 0.360 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.378732e-01 0.359 0 0
RUNX2 regulates bone development R-HSA-8941326 4.378732e-01 0.359 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.407498e-01 0.356 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.422334e-01 0.354 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.422334e-01 0.354 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.422334e-01 0.354 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.422334e-01 0.354 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.422334e-01 0.354 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.422334e-01 0.354 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.422334e-01 0.354 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.422334e-01 0.354 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.422334e-01 0.354 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.422334e-01 0.354 0 0
Interleukin-33 signaling R-HSA-9014843 4.422334e-01 0.354 0 0
Generic Transcription Pathway R-HSA-212436 4.426833e-01 0.354 1 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.439578e-01 0.353 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.446743e-01 0.352 0 0
Mitochondrial biogenesis R-HSA-1592230 4.501467e-01 0.347 0 0
Glucose metabolism R-HSA-70326 4.501467e-01 0.347 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.513446e-01 0.345 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.513446e-01 0.345 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.513446e-01 0.345 0 0
Ub-specific processing proteases R-HSA-5689880 4.514497e-01 0.345 0 0
Budding and maturation of HIV virion R-HSA-162588 4.538808e-01 0.343 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.573668e-01 0.340 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.611164e-01 0.336 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.634866e-01 0.334 1 0
STING mediated induction of host immune responses R-HSA-1834941 4.639774e-01 0.334 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.670575e-01 0.331 0 0
Reproduction R-HSA-1474165 4.689997e-01 0.329 0 0
Interleukin-7 signaling R-HSA-1266695 4.725415e-01 0.326 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.768005e-01 0.322 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.768005e-01 0.322 0 0
Interleukin-9 signaling R-HSA-8985947 4.768432e-01 0.322 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.768432e-01 0.322 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.768432e-01 0.322 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.827753e-01 0.316 0 0
Cilium Assembly R-HSA-5617833 4.881902e-01 0.311 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.883748e-01 0.311 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.883748e-01 0.311 0 0
Signal regulatory protein family interactions R-HSA-391160 4.883748e-01 0.311 0 0
RMTs methylate histone arginines R-HSA-3214858 4.884451e-01 0.311 0 0
Formation of definitive endoderm R-HSA-9823730 4.951288e-01 0.305 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.999433e-01 0.301 0 0
TRP channels R-HSA-3295583 4.999433e-01 0.301 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.999433e-01 0.301 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.009551e-01 0.300 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.037268e-01 0.298 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.037268e-01 0.298 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.068749e-01 0.295 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.095928e-01 0.293 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.120002e-01 0.291 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.120002e-01 0.291 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.141726e-01 0.289 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.160140e-01 0.287 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.164438e-01 0.287 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.164438e-01 0.287 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.179903e-01 0.286 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.179903e-01 0.286 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.179903e-01 0.286 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.179903e-01 0.286 0 0
MET activates PTPN11 R-HSA-8865999 5.179903e-01 0.286 0 0
Signalling to STAT3 R-HSA-198745 5.179903e-01 0.286 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.179903e-01 0.286 0 0
Invadopodia formation R-HSA-8941237 5.179903e-01 0.286 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.179903e-01 0.286 0 0
The NLRP1 inflammasome R-HSA-844455 5.179903e-01 0.286 0 0
Ca2+ pathway R-HSA-4086398 5.180002e-01 0.286 0 0
Signaling by NOTCH R-HSA-157118 5.184044e-01 0.285 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.197171e-01 0.284 1 1
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.225796e-01 0.282 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.225796e-01 0.282 1 1
Calcineurin activates NFAT R-HSA-2025928 5.225796e-01 0.282 0 0
mRNA Editing R-HSA-75072 5.225796e-01 0.282 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.225796e-01 0.282 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.225796e-01 0.282 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.225796e-01 0.282 0 0
ARMS-mediated activation R-HSA-170984 5.225796e-01 0.282 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.225796e-01 0.282 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.225796e-01 0.282 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.225796e-01 0.282 0 0
Erythropoietin activates RAS R-HSA-9027284 5.241411e-01 0.281 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.241411e-01 0.281 0 0
Other semaphorin interactions R-HSA-416700 5.241411e-01 0.281 0 0
Basigin interactions R-HSA-210991 5.254847e-01 0.279 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.254847e-01 0.279 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 5.254847e-01 0.279 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 5.254847e-01 0.279 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.254847e-01 0.279 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.254847e-01 0.279 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.267787e-01 0.278 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.280376e-01 0.277 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.295131e-01 0.276 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.304499e-01 0.275 0 0
Signaling by TGFBR3 R-HSA-9839373 5.304499e-01 0.275 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.316038e-01 0.274 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.327246e-01 0.273 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.327246e-01 0.273 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.509701e-01 0.259 0 0
Transcription of the HIV genome R-HSA-167172 5.512462e-01 0.259 0 0
Protein ubiquitination R-HSA-8852135 5.515496e-01 0.258 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.549287e-01 0.256 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.549287e-01 0.256 0 0
Differentiation of T cells R-HSA-9945266 5.584847e-01 0.253 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.584847e-01 0.253 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.584847e-01 0.253 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.584847e-01 0.253 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.584847e-01 0.253 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.584847e-01 0.253 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.655471e-01 0.248 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.655471e-01 0.248 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.655471e-01 0.248 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.655471e-01 0.248 0 0
Regulation of CDH11 function R-HSA-9762292 5.655471e-01 0.248 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.655471e-01 0.248 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.655471e-01 0.248 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.655471e-01 0.248 0 0
Formation of apoptosome R-HSA-111458 5.655471e-01 0.248 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.675005e-01 0.246 0 0
Interleukin-1 signaling R-HSA-9020702 5.675133e-01 0.246 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.690469e-01 0.245 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.727696e-01 0.242 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.784111e-01 0.238 0 0
Platelet calcium homeostasis R-HSA-418360 5.784111e-01 0.238 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.784111e-01 0.238 0 0
PI Metabolism R-HSA-1483255 5.815957e-01 0.235 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.833662e-01 0.234 0 0
Signaling by KIT in disease R-HSA-9669938 5.833662e-01 0.234 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.833662e-01 0.234 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.834615e-01 0.234 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.834615e-01 0.234 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.834615e-01 0.234 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.834615e-01 0.234 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.834615e-01 0.234 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.834615e-01 0.234 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.834615e-01 0.234 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.834615e-01 0.234 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.834615e-01 0.234 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.834615e-01 0.234 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.834615e-01 0.234 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.912885e-01 0.228 0 0
Phase 2 - plateau phase R-HSA-5576893 5.912885e-01 0.228 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.912885e-01 0.228 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.912885e-01 0.228 0 0
GPVI-mediated activation cascade R-HSA-114604 5.977169e-01 0.224 1 1
Triglyceride catabolism R-HSA-163560 5.977169e-01 0.224 0 0
FLT3 signaling in disease R-HSA-9682385 5.977169e-01 0.224 0 0
Formation of the posterior neural plate R-HSA-9832991 6.056539e-01 0.218 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.056539e-01 0.218 0 0
Suppression of apoptosis R-HSA-9635465 6.056539e-01 0.218 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.056539e-01 0.218 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.107225e-01 0.214 0 0
Carnitine shuttle R-HSA-200425 6.107225e-01 0.214 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.107225e-01 0.214 1 1
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.137526e-01 0.212 0 0
Signaling by FGFR4 R-HSA-5654743 6.142850e-01 0.212 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.142850e-01 0.212 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.152816e-01 0.211 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.224724e-01 0.206 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.224724e-01 0.206 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.224724e-01 0.206 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.224724e-01 0.206 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.224724e-01 0.206 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.224724e-01 0.206 0 0
PPARA activates gene expression R-HSA-1989781 6.256861e-01 0.204 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.288990e-01 0.201 0 0
PKR-mediated signaling R-HSA-9833482 6.311675e-01 0.200 0 0
Transmission across Chemical Synapses R-HSA-112315 6.350314e-01 0.197 1 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.369413e-01 0.196 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.369413e-01 0.196 0 0
HATs acetylate histones R-HSA-3214847 6.380283e-01 0.195 0 0
Activation of AMPA receptors R-HSA-399710 6.400431e-01 0.194 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.400431e-01 0.194 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.400431e-01 0.194 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.400431e-01 0.194 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.400431e-01 0.194 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.400431e-01 0.194 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.400431e-01 0.194 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.400431e-01 0.194 0 0
Activation of C3 and C5 R-HSA-174577 6.400431e-01 0.194 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.400431e-01 0.194 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.400431e-01 0.194 0 0
Reelin signalling pathway R-HSA-8866376 6.400431e-01 0.194 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.400431e-01 0.194 0 0
Inositol transporters R-HSA-429593 6.400431e-01 0.194 0 0
Interleukin-36 pathway R-HSA-9014826 6.400431e-01 0.194 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.400431e-01 0.194 0 0
NrCAM interactions R-HSA-447038 6.400431e-01 0.194 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.400431e-01 0.194 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.409513e-01 0.193 0 0
Toll-like Receptor Cascades R-HSA-168898 6.424123e-01 0.192 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.428844e-01 0.192 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.428844e-01 0.192 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.428844e-01 0.192 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.428844e-01 0.192 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.428844e-01 0.192 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.428844e-01 0.192 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.444203e-01 0.191 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.473180e-01 0.189 0 0
SARS-CoV Infections R-HSA-9679506 6.482834e-01 0.188 1 0
Signaling by Interleukins R-HSA-449147 6.491747e-01 0.188 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.498164e-01 0.187 0 0
Mismatch Repair R-HSA-5358508 6.519877e-01 0.186 0 0
Apoptotic factor-mediated response R-HSA-111471 6.519877e-01 0.186 0 0
Signaling by FGFR3 R-HSA-5654741 6.535186e-01 0.185 0 0
Diseases of programmed cell death R-HSA-9645723 6.573237e-01 0.182 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.614910e-01 0.179 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.614910e-01 0.179 0 0
RAS processing R-HSA-9648002 6.614910e-01 0.179 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.619831e-01 0.179 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.649415e-01 0.177 0 0
Iron uptake and transport R-HSA-917937 6.650302e-01 0.177 0 0
Interferon Signaling R-HSA-913531 6.698189e-01 0.174 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.708490e-01 0.173 1 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.722130e-01 0.172 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.742949e-01 0.171 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.754506e-01 0.170 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.772799e-01 0.169 0 0
Polymerase switching R-HSA-69091 6.772799e-01 0.169 0 0
Leading Strand Synthesis R-HSA-69109 6.772799e-01 0.169 0 0
OAS antiviral response R-HSA-8983711 6.772799e-01 0.169 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.798133e-01 0.168 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.798133e-01 0.168 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.798133e-01 0.168 0 0
Maturation of nucleoprotein R-HSA-9694631 6.798133e-01 0.168 0 0
HIV Transcription Elongation R-HSA-167169 6.812793e-01 0.167 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.812793e-01 0.167 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.812793e-01 0.167 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.812793e-01 0.167 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.821527e-01 0.166 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.858236e-01 0.164 0 0
Myogenesis R-HSA-525793 6.858236e-01 0.164 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.858236e-01 0.164 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.858236e-01 0.164 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.889415e-01 0.162 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.889415e-01 0.162 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.889415e-01 0.162 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.889415e-01 0.162 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.889415e-01 0.162 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.889415e-01 0.162 0 0
Signaling by MAPK mutants R-HSA-9652817 6.889415e-01 0.162 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.889415e-01 0.162 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.889415e-01 0.162 0 0
Signaling by MST1 R-HSA-8852405 6.889415e-01 0.162 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.889415e-01 0.162 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.889415e-01 0.162 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.889415e-01 0.162 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.889415e-01 0.162 0 0
PDE3B signalling R-HSA-165160 6.889415e-01 0.162 0 0
Synthesis of PS R-HSA-1483101 6.889415e-01 0.162 0 0
PKB-mediated events R-HSA-109703 6.889415e-01 0.162 0 0
Phosphorylation of Emi1 R-HSA-176417 6.889415e-01 0.162 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.889415e-01 0.162 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.889415e-01 0.162 0 0
Diseases of Base Excision Repair R-HSA-9605308 6.889415e-01 0.162 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.889415e-01 0.162 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.889415e-01 0.162 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.892646e-01 0.162 0 0
Signaling by PDGF R-HSA-186797 6.914339e-01 0.160 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.943268e-01 0.158 0 0
G alpha (z) signalling events R-HSA-418597 6.988038e-01 0.156 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.059506e-01 0.151 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.067041e-01 0.151 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.067041e-01 0.151 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.084515e-01 0.150 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.084515e-01 0.150 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.084515e-01 0.150 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.089236e-01 0.149 0 0
Maturation of nucleoprotein R-HSA-9683610 7.089236e-01 0.149 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.112285e-01 0.148 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.130499e-01 0.147 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.130499e-01 0.147 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.130499e-01 0.147 0 0
Gastrulation R-HSA-9758941 7.131051e-01 0.147 0 0
RSV-host interactions R-HSA-9833110 7.142734e-01 0.146 0 0
Hedgehog 'on' state R-HSA-5632684 7.146424e-01 0.146 0 0
Signaling by FGFR1 R-HSA-5654736 7.148840e-01 0.146 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.185408e-01 0.144 0 0
HIV Transcription Initiation R-HSA-167161 7.185408e-01 0.144 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.185408e-01 0.144 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.185408e-01 0.144 0 0
Translation of Structural Proteins R-HSA-9683701 7.185408e-01 0.144 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.244034e-01 0.140 0 0
Co-inhibition by PD-1 R-HSA-389948 7.251283e-01 0.140 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.286770e-01 0.137 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.290455e-01 0.137 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.298674e-01 0.137 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.298674e-01 0.137 0 0
Lagging Strand Synthesis R-HSA-69186 7.304201e-01 0.136 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.304201e-01 0.136 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.304201e-01 0.136 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.311998e-01 0.136 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.311998e-01 0.136 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.311998e-01 0.136 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.311998e-01 0.136 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.311998e-01 0.136 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.311998e-01 0.136 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.311998e-01 0.136 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.311998e-01 0.136 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.311998e-01 0.136 0 0
MET Receptor Activation R-HSA-6806942 7.311998e-01 0.136 0 0
NADPH regeneration R-HSA-389542 7.311998e-01 0.136 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.311998e-01 0.136 0 0
Abacavir transmembrane transport R-HSA-2161517 7.311998e-01 0.136 0 0
Lactose synthesis R-HSA-5653890 7.311998e-01 0.136 0 0
Leukotriene receptors R-HSA-391906 7.311998e-01 0.136 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.379283e-01 0.132 0 0
Removal of the Flap Intermediate R-HSA-69166 7.379283e-01 0.132 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.379283e-01 0.132 0 0
cGMP effects R-HSA-418457 7.379283e-01 0.132 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.379283e-01 0.132 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.415446e-01 0.130 0 0
Hedgehog 'off' state R-HSA-5610787 7.422365e-01 0.129 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.453046e-01 0.128 0 0
Dual incision in TC-NER R-HSA-6782135 7.453046e-01 0.128 0 0
Gene Silencing by RNA R-HSA-211000 7.484351e-01 0.126 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.504669e-01 0.125 0 0
RNA Polymerase III Transcription R-HSA-74158 7.504669e-01 0.125 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.526697e-01 0.123 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.532575e-01 0.123 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.644268e-01 0.117 0 0
p38MAPK events R-HSA-171007 7.644268e-01 0.117 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.644268e-01 0.117 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.644268e-01 0.117 0 0
Biotin transport and metabolism R-HSA-196780 7.644268e-01 0.117 0 0
Protein methylation R-HSA-8876725 7.644268e-01 0.117 0 0
Formation of the anterior neural plate R-HSA-9823739 7.644268e-01 0.117 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.677193e-01 0.115 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.677193e-01 0.115 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.677193e-01 0.115 0 0
Recycling of eIF2:GDP R-HSA-72731 7.677193e-01 0.115 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.677193e-01 0.115 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.677193e-01 0.115 0 0
Opsins R-HSA-419771 7.677193e-01 0.115 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.677193e-01 0.115 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.677193e-01 0.115 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.677193e-01 0.115 0 0
Netrin mediated repulsion signals R-HSA-418886 7.677193e-01 0.115 0 0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) R-HSA-9026762 7.677193e-01 0.115 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.677193e-01 0.115 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.677600e-01 0.115 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.690173e-01 0.114 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.691142e-01 0.114 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.723409e-01 0.112 0 0
FGFR2 alternative splicing R-HSA-6803529 7.745109e-01 0.111 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.745109e-01 0.111 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.745109e-01 0.111 0 0
Regulated Necrosis R-HSA-5218859 7.766367e-01 0.110 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.836789e-01 0.106 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.885647e-01 0.103 0 0
Killing mechanisms R-HSA-9664420 7.885647e-01 0.103 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.885647e-01 0.103 0 0
Integration of energy metabolism R-HSA-163685 7.889501e-01 0.103 0 0
Influenza Infection R-HSA-168255 7.919834e-01 0.101 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.942376e-01 0.100 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.942376e-01 0.100 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.942376e-01 0.100 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.942376e-01 0.100 0 0
Formation of the ureteric bud R-HSA-9830674 7.942376e-01 0.100 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.942376e-01 0.100 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.980354e-01 0.098 0 0
IRE1alpha activates chaperones R-HSA-381070 7.982101e-01 0.098 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.992790e-01 0.097 0 0
MET receptor recycling R-HSA-8875656 7.992790e-01 0.097 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.992790e-01 0.097 0 0
Interleukin-23 signaling R-HSA-9020933 7.992790e-01 0.097 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.992790e-01 0.097 0 0
Regulation by c-FLIP R-HSA-3371378 7.992790e-01 0.097 0 0
Co-stimulation by ICOS R-HSA-9927354 7.992790e-01 0.097 0 0
Adrenoceptors R-HSA-390696 7.992790e-01 0.097 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.992790e-01 0.097 0 0
Dimerization of procaspase-8 R-HSA-69416 7.992790e-01 0.097 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.992790e-01 0.097 0 0
Sodium/Proton exchangers R-HSA-425986 7.992790e-01 0.097 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.992790e-01 0.097 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.995835e-01 0.097 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.031192e-01 0.095 0 0
Protein folding R-HSA-391251 8.083801e-01 0.092 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.104942e-01 0.091 0 0
Fibronectin matrix formation R-HSA-1566977 8.104942e-01 0.091 0 0
Coenzyme A biosynthesis R-HSA-196783 8.104942e-01 0.091 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.104942e-01 0.091 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.111857e-01 0.091 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.116447e-01 0.091 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.122826e-01 0.090 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.125020e-01 0.090 0 0
Glycogen metabolism R-HSA-8982491 8.141542e-01 0.089 0 0
Interleukin-2 family signaling R-HSA-451927 8.141542e-01 0.089 0 0
Ion homeostasis R-HSA-5578775 8.229878e-01 0.085 0 0
Signaling by FGFR2 R-HSA-5654738 8.242480e-01 0.084 0 0
GPER1 signaling R-HSA-9634597 8.245239e-01 0.084 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.265523e-01 0.083 0 0
CASP8 activity is inhibited R-HSA-5218900 8.265523e-01 0.083 0 0
ALK mutants bind TKIs R-HSA-9700645 8.265523e-01 0.083 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.265523e-01 0.083 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.265523e-01 0.083 0 0
Interleukin-21 signaling R-HSA-9020958 8.265523e-01 0.083 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.265523e-01 0.083 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.265523e-01 0.083 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.265523e-01 0.083 0 0
Interleukin-1 processing R-HSA-448706 8.265523e-01 0.083 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.265523e-01 0.083 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.265523e-01 0.083 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.293735e-01 0.081 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.293735e-01 0.081 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.303696e-01 0.081 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.303696e-01 0.081 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.303696e-01 0.081 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.303696e-01 0.081 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.318243e-01 0.080 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.318243e-01 0.080 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.340292e-01 0.079 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.340292e-01 0.079 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.340292e-01 0.079 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.407397e-01 0.075 0 0
Intra-Golgi traffic R-HSA-6811438 8.407397e-01 0.075 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.407397e-01 0.075 0 0
Interferon alpha/beta signaling R-HSA-909733 8.421344e-01 0.075 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.433297e-01 0.074 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.442363e-01 0.074 0 0
ER-Phagosome pathway R-HSA-1236974 8.442589e-01 0.074 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.449247e-01 0.073 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.449247e-01 0.073 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.449247e-01 0.073 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.452893e-01 0.073 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.476468e-01 0.072 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.476468e-01 0.072 0 0
PI3K Cascade R-HSA-109704 8.481710e-01 0.072 1 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.483443e-01 0.071 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.483443e-01 0.071 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.483443e-01 0.071 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.483443e-01 0.071 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.483443e-01 0.071 0 0
Tie2 Signaling R-HSA-210993 8.483443e-01 0.071 0 0
Nephron development R-HSA-9831926 8.483443e-01 0.071 0 0
Platelet sensitization by LDL R-HSA-432142 8.483443e-01 0.071 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.483443e-01 0.071 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.501212e-01 0.071 0 0
DNA replication initiation R-HSA-68952 8.501212e-01 0.071 0 0
Binding and entry of HIV virion R-HSA-173107 8.501212e-01 0.071 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.501212e-01 0.071 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.501212e-01 0.071 0 0
2-LTR circle formation R-HSA-164843 8.501212e-01 0.071 0 0
Arachidonate production from DAG R-HSA-426048 8.501212e-01 0.071 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.501212e-01 0.071 0 0
Interleukin-27 signaling R-HSA-9020956 8.501212e-01 0.071 0 0
Serotonin receptors R-HSA-390666 8.501212e-01 0.071 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.528125e-01 0.069 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.555457e-01 0.068 0 0
Extension of Telomeres R-HSA-180786 8.557470e-01 0.068 0 0
Triglyceride metabolism R-HSA-8979227 8.557470e-01 0.068 0 0
Neuronal System R-HSA-112316 8.573912e-01 0.067 1 0
Ion channel transport R-HSA-983712 8.589649e-01 0.066 0 0
Cristae formation R-HSA-8949613 8.592298e-01 0.066 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.592298e-01 0.066 0 0
Insulin processing R-HSA-264876 8.592298e-01 0.066 0 0
PERK regulates gene expression R-HSA-381042 8.603074e-01 0.065 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.611967e-01 0.065 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.631986e-01 0.064 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.632022e-01 0.064 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.632022e-01 0.064 0 0
Adaptive Immune System R-HSA-1280218 8.640163e-01 0.063 1 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.645676e-01 0.063 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.645676e-01 0.063 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.645676e-01 0.063 0 0
Other interleukin signaling R-HSA-449836 8.645676e-01 0.063 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.686218e-01 0.061 0 0
Translation of Structural Proteins R-HSA-9694635 8.703965e-01 0.060 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.704886e-01 0.060 0 0
vRNA Synthesis R-HSA-192814 8.704886e-01 0.060 0 0
Bicarbonate transporters R-HSA-425381 8.704886e-01 0.060 0 0
Transport of RCbl within the body R-HSA-9758890 8.704886e-01 0.060 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.704886e-01 0.060 0 0
LGI-ADAM interactions R-HSA-5682910 8.704886e-01 0.060 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 8.704886e-01 0.060 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.704886e-01 0.060 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.704886e-01 0.060 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.720576e-01 0.059 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.720576e-01 0.059 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.720668e-01 0.059 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.723638e-01 0.059 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.723638e-01 0.059 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.723638e-01 0.059 0 0
Telomere Extension By Telomerase R-HSA-171319 8.723638e-01 0.059 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.747188e-01 0.058 1 0
Platelet activation, signaling and aggregation R-HSA-76002 8.749542e-01 0.058 1 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.766415e-01 0.057 0 0
ABC transporter disorders R-HSA-5619084 8.784967e-01 0.056 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.791836e-01 0.056 0 0
Signaling by NODAL R-HSA-1181150 8.791836e-01 0.056 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.791836e-01 0.056 0 0
Protein hydroxylation R-HSA-9629569 8.791836e-01 0.056 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.834012e-01 0.054 0 0
ABC-family proteins mediated transport R-HSA-382556 8.834026e-01 0.054 0 0
Signaling by Erythropoietin R-HSA-9006335 8.844009e-01 0.053 0 0
mRNA Capping R-HSA-72086 8.844009e-01 0.053 0 0
Somitogenesis R-HSA-9824272 8.845312e-01 0.053 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.845312e-01 0.053 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.845312e-01 0.053 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.880892e-01 0.052 0 0
Integration of provirus R-HSA-162592 8.880892e-01 0.052 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.880892e-01 0.052 0 0
ERKs are inactivated R-HSA-202670 8.880892e-01 0.052 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.880892e-01 0.052 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.880892e-01 0.052 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.880892e-01 0.052 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.880892e-01 0.052 0 0
Anchoring fibril formation R-HSA-2214320 8.880892e-01 0.052 0 0
DS-GAG biosynthesis R-HSA-2022923 8.880892e-01 0.052 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.883903e-01 0.051 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.923294e-01 0.049 0 0
Signalling to RAS R-HSA-167044 8.923294e-01 0.049 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.930160e-01 0.049 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.937152e-01 0.049 0 0
HCMV Early Events R-HSA-9609690 8.951712e-01 0.048 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.954140e-01 0.048 0 0
Interleukin-37 signaling R-HSA-9008059 8.954140e-01 0.048 0 0
IGF1R signaling cascade R-HSA-2428924 8.992594e-01 0.046 1 0
Insulin receptor signalling cascade R-HSA-74751 8.992594e-01 0.046 1 0
Interleukin-1 family signaling R-HSA-446652 9.029677e-01 0.044 0 0
MET activates RAS signaling R-HSA-8851805 9.032988e-01 0.044 0 0
Interleukin-15 signaling R-HSA-8983432 9.032988e-01 0.044 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.032988e-01 0.044 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.032988e-01 0.044 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 9.032988e-01 0.044 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.032988e-01 0.044 0 0
Interleukin-35 Signalling R-HSA-8984722 9.032988e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.041346e-01 0.044 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.041346e-01 0.044 0 0
Cargo concentration in the ER R-HSA-5694530 9.054741e-01 0.043 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.064764e-01 0.043 1 0
Signaling by FGFR in disease R-HSA-1226099 9.095920e-01 0.041 0 0
Base Excision Repair R-HSA-73884 9.108307e-01 0.041 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.108982e-01 0.041 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.108982e-01 0.041 0 0
Diseases of Immune System R-HSA-5260271 9.108982e-01 0.041 0 0
IRS-mediated signalling R-HSA-112399 9.112246e-01 0.040 1 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.129913e-01 0.040 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.146499e-01 0.039 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.147207e-01 0.039 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.147207e-01 0.039 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.158516e-01 0.038 0 0
Interleukin-6 signaling R-HSA-1059683 9.164420e-01 0.038 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 9.164420e-01 0.038 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.164420e-01 0.038 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.164420e-01 0.038 0 0
tRNA processing R-HSA-72306 9.174423e-01 0.037 0 0
Gap junction trafficking and regulation R-HSA-157858 9.175716e-01 0.037 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.193601e-01 0.037 0 0
Kidney development R-HSA-9830369 9.195894e-01 0.036 0 0
Regulation of insulin secretion R-HSA-422356 9.200827e-01 0.036 0 0
Signaling by FGFR R-HSA-190236 9.200827e-01 0.036 0 0
Interleukin-20 family signaling R-HSA-8854691 9.242009e-01 0.034 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.242009e-01 0.034 0 0
Peroxisomal protein import R-HSA-9033241 9.244414e-01 0.034 0 0
Chromosome Maintenance R-HSA-73886 9.261839e-01 0.033 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.269799e-01 0.033 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.277995e-01 0.033 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.277995e-01 0.033 0 0
Prolactin receptor signaling R-HSA-1170546 9.277995e-01 0.033 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.277995e-01 0.033 0 0
Malate-aspartate shuttle R-HSA-9856872 9.277995e-01 0.033 0 0
Zinc transporters R-HSA-435354 9.277995e-01 0.033 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.277995e-01 0.033 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.286728e-01 0.032 0 0
Potential therapeutics for SARS R-HSA-9679191 9.287097e-01 0.032 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.306084e-01 0.031 0 0
Meiotic recombination R-HSA-912446 9.307253e-01 0.031 0 0
Interleukin-10 signaling R-HSA-6783783 9.324452e-01 0.030 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.326803e-01 0.030 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.326803e-01 0.030 0 0
Complex III assembly R-HSA-9865881 9.326803e-01 0.030 0 0
Depyrimidination R-HSA-73928 9.327454e-01 0.030 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.327454e-01 0.030 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.327454e-01 0.030 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.342837e-01 0.030 1 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.360467e-01 0.029 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.362622e-01 0.029 0 0
COPII-mediated vesicle transport R-HSA-204005 9.362622e-01 0.029 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.365720e-01 0.028 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.375133e-01 0.028 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.375133e-01 0.028 0 0
Hyaluronan metabolism R-HSA-2142845 9.375133e-01 0.028 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.375133e-01 0.028 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.376139e-01 0.028 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.376139e-01 0.028 0 0
Signaling by Activin R-HSA-1502540 9.376139e-01 0.028 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.402557e-01 0.027 0 0
Laminin interactions R-HSA-3000157 9.402557e-01 0.027 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.402557e-01 0.027 0 0
Hyaluronan degradation R-HSA-2160916 9.402557e-01 0.027 0 0
Formation of the nephric duct R-HSA-9830364 9.402557e-01 0.027 0 0
Ribosome-associated quality control R-HSA-9948299 9.403819e-01 0.027 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.410999e-01 0.026 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.418530e-01 0.026 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.419718e-01 0.026 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.419718e-01 0.026 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.437778e-01 0.025 0 0
Gap junction trafficking R-HSA-190828 9.444848e-01 0.025 0 0
Proteasome assembly R-HSA-9907900 9.444848e-01 0.025 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.445597e-01 0.025 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.452515e-01 0.024 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.460946e-01 0.024 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.460946e-01 0.024 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.460946e-01 0.024 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.460946e-01 0.024 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.460946e-01 0.024 0 0
Attachment and Entry R-HSA-9678110 9.460946e-01 0.024 0 0
Atorvastatin ADME R-HSA-9754706 9.460946e-01 0.024 0 0
Amyloid fiber formation R-HSA-977225 9.461088e-01 0.024 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.462549e-01 0.024 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.470161e-01 0.024 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.470161e-01 0.024 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.477583e-01 0.023 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.478595e-01 0.023 1 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.496231e-01 0.022 0 0
Nucleosome assembly R-HSA-774815 9.496231e-01 0.022 0 0
Ion transport by P-type ATPases R-HSA-936837 9.501938e-01 0.022 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.504957e-01 0.022 0 0
Neurotransmitter release cycle R-HSA-112310 9.508213e-01 0.022 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.513996e-01 0.022 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.515447e-01 0.022 0 0
Telomere Maintenance R-HSA-157579 9.518711e-01 0.021 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.530431e-01 0.021 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.530431e-01 0.021 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.530431e-01 0.021 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.534229e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.534229e-01 0.021 0 0
Passive transport by Aquaporins R-HSA-432047 9.534229e-01 0.021 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.534229e-01 0.021 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.543213e-01 0.020 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.559909e-01 0.020 0 0
Interferon gamma signaling R-HSA-877300 9.568916e-01 0.019 0 0
Inflammasomes R-HSA-622312 9.584110e-01 0.018 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.592275e-01 0.018 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.597553e-01 0.018 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.597553e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.597553e-01 0.018 0 0
Choline catabolism R-HSA-6798163 9.597553e-01 0.018 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.597553e-01 0.018 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.607121e-01 0.017 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.620016e-01 0.017 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.631878e-01 0.016 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.631878e-01 0.016 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.634369e-01 0.016 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.634369e-01 0.016 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.638682e-01 0.016 0 0
Signaling by Hedgehog R-HSA-5358351 9.639935e-01 0.016 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.652271e-01 0.015 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.652271e-01 0.015 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.652271e-01 0.015 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.652271e-01 0.015 0 0
GAB1 signalosome R-HSA-180292 9.652271e-01 0.015 0 0
Biosynthesis of DHA-derived sulfido conjugates R-HSA-9026395 9.652271e-01 0.015 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.662758e-01 0.015 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.665093e-01 0.015 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.672244e-01 0.014 0 0
DAP12 signaling R-HSA-2424491 9.674348e-01 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.674348e-01 0.014 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.687821e-01 0.014 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.699552e-01 0.013 0 0
Pyrimidine biosynthesis R-HSA-500753 9.699552e-01 0.013 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.699552e-01 0.013 0 0
Diseases of hemostasis R-HSA-9671793 9.699552e-01 0.013 0 0
The NLRP3 inflammasome R-HSA-844456 9.699552e-01 0.013 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.699552e-01 0.013 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.706392e-01 0.013 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.712077e-01 0.013 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.712077e-01 0.013 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.712077e-01 0.013 0 0
Aquaporin-mediated transport R-HSA-445717 9.722716e-01 0.012 0 0
The phototransduction cascade R-HSA-2514856 9.723049e-01 0.012 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.737151e-01 0.012 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.737151e-01 0.012 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.740407e-01 0.011 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.740407e-01 0.011 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.740407e-01 0.011 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.749932e-01 0.011 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.764835e-01 0.010 0 0
HCMV Infection R-HSA-9609646 9.769125e-01 0.010 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.771657e-01 0.010 1 1
Smooth Muscle Contraction R-HSA-445355 9.774349e-01 0.010 0 0
Recycling of bile acids and salts R-HSA-159418 9.775281e-01 0.010 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.775708e-01 0.010 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.775978e-01 0.010 0 0
Defective pyroptosis R-HSA-9710421 9.789729e-01 0.009 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.793890e-01 0.009 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.796507e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.801619e-01 0.009 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.806210e-01 0.008 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.806210e-01 0.008 0 0
Attachment and Entry R-HSA-9694614 9.806210e-01 0.008 0 0
Neddylation R-HSA-8951664 9.812275e-01 0.008 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.812662e-01 0.008 0 0
Signal amplification R-HSA-392518 9.824951e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.828943e-01 0.007 0 0
HCMV Late Events R-HSA-9610379 9.829484e-01 0.007 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.832566e-01 0.007 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.832566e-01 0.007 0 0
Cellular hexose transport R-HSA-189200 9.832566e-01 0.007 0 0
LDL clearance R-HSA-8964038 9.832566e-01 0.007 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.832566e-01 0.007 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.834441e-01 0.007 0 0
Cellular response to starvation R-HSA-9711097 9.840554e-01 0.007 0 0
SLC transporter disorders R-HSA-5619102 9.844279e-01 0.007 0 0
Dectin-2 family R-HSA-5621480 9.851290e-01 0.007 0 0
Platelet degranulation R-HSA-114608 9.854484e-01 0.006 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.855339e-01 0.006 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.855339e-01 0.006 0 0
Biosynthesis of maresins R-HSA-9018682 9.855339e-01 0.006 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.855339e-01 0.006 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.855339e-01 0.006 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.855339e-01 0.006 0 0
RNA Polymerase I Transcription R-HSA-73864 9.858331e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.863885e-01 0.006 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.866203e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.866354e-01 0.006 0 0
Peptide chain elongation R-HSA-156902 9.872625e-01 0.006 0 0
CYP2E1 reactions R-HSA-211999 9.875015e-01 0.005 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.875015e-01 0.005 0 0
Interleukin-6 family signaling R-HSA-6783589 9.875015e-01 0.005 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.875015e-01 0.005 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.875015e-01 0.005 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.875015e-01 0.005 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.875015e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.880048e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.880048e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.880048e-01 0.005 0 0
Metal ion SLC transporters R-HSA-425410 9.880827e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.890623e-01 0.005 0 0
Platelet homeostasis R-HSA-418346 9.891084e-01 0.005 0 0
RAB geranylgeranylation R-HSA-8873719 9.891867e-01 0.005 0 0
Glutathione conjugation R-HSA-156590 9.891867e-01 0.005 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.892016e-01 0.005 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.892016e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.894334e-01 0.005 0 0
Hemostasis R-HSA-109582 9.902332e-01 0.004 1 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.906706e-01 0.004 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.906706e-01 0.004 0 0
Urea cycle R-HSA-70635 9.906706e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.906706e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.906706e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.907145e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.907145e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.907145e-01 0.004 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.915064e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.918096e-01 0.004 0 0
Signaling by Insulin receptor R-HSA-74752 9.919394e-01 0.004 1 0
Packaging Of Telomere Ends R-HSA-171306 9.919398e-01 0.004 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.919398e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.919398e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.919398e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.919398e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.919398e-01 0.004 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.919398e-01 0.004 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.919398e-01 0.004 0 0
Selenocysteine synthesis R-HSA-2408557 9.920372e-01 0.003 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.927930e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.927930e-01 0.003 0 0
Developmental Cell Lineages R-HSA-9734767 9.930183e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.930364e-01 0.003 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.930364e-01 0.003 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.930364e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.930364e-01 0.003 0 0
Pyroptosis R-HSA-5620971 9.930364e-01 0.003 0 0
Muscle contraction R-HSA-397014 9.931213e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.936605e-01 0.003 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.937560e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.939838e-01 0.003 0 0
Eukaryotic Translation Termination R-HSA-72764 9.944582e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.946034e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.947277e-01 0.002 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.948024e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.949258e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.955097e-01 0.002 0 0
DAP12 interactions R-HSA-2172127 9.956935e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.956935e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.956935e-01 0.002 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.961207e-01 0.002 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.966486e-01 0.001 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.966486e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.966486e-01 0.001 0 0
Cardiogenesis R-HSA-9733709 9.966486e-01 0.001 0 0
rRNA processing R-HSA-72312 9.967560e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.967615e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.967615e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.970920e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.970920e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.970920e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.971047e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.971047e-01 0.001 0 0
Heme degradation R-HSA-189483 9.971047e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.972035e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.974211e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.974349e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.974988e-01 0.001 0 0
eNOS activation R-HSA-203615 9.974988e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.975874e-01 0.001 0 0
Neutrophil degranulation R-HSA-6798695 9.977951e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.978392e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.978392e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.978392e-01 0.001 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.978392e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.979677e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.980282e-01 0.001 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.980282e-01 0.001 0 0
Voltage gated Potassium channels R-HSA-1296072 9.983875e-01 0.001 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.983875e-01 0.001 0 0
Cleavage of the damaged purine R-HSA-110331 9.983875e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.983875e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.983875e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.984833e-01 0.001 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.984833e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.985351e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.985601e-01 0.001 0 0
Depurination R-HSA-73927 9.986070e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.986070e-01 0.001 0 0
Purine salvage R-HSA-74217 9.986070e-01 0.001 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.986070e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.986703e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.987966e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.987966e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988978e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.988978e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.989255e-01 0.000 1 0
FCERI mediated MAPK activation R-HSA-2871796 9.990546e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.991020e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.991020e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.991052e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.991379e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.991854e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.992378e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.993299e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.993989e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.994212e-01 0.000 0 0
Protein localization R-HSA-9609507 9.994262e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.994738e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.994782e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994941e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.995000e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.995000e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995394e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.995681e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.995681e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.995681e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.995831e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.995970e-01 0.000 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.996269e-01 0.000 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.996269e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996275e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.996778e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996778e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996807e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.996968e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997183e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.997217e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.997217e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997447e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997596e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997634e-01 0.000 0 0
Translation R-HSA-72766 9.997770e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.997791e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.997809e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997907e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997923e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997937e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997937e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.997944e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998206e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.998206e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998229e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998941e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.998948e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998974e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999002e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999057e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999117e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999152e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999152e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999245e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999291e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999424e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999586e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999733e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999733e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999780e-01 0.000 1 1
Nicotinate metabolism R-HSA-196807 9.999828e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999863e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999889e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999904e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999917e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999917e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999917e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999920e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999920e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999929e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999936e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999947e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999951e-01 0.000 1 0
FCGR activation R-HSA-2029481 9.999954e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999961e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999973e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999974e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999978e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999980e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999982e-01 0.000 0 0
Immune System R-HSA-168256 9.999984e-01 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999993e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999994e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 1 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 1 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways