AKT2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14492	S598	SIGNOR	SH2B2 APS	SGPAPPRPVEGQLSARsRsNsAERLLEAVAATAAEEPPEAA
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14746	S227	SIGNOR\|ELM	TERT EST2 TCS1 TRT	VREAGVPLGLPAPGARRRGGsASRSLPLPKRPRRGAAPEPE
O14746	S824	SIGNOR\|ELM	TERT EST2 TCS1 TRT	GLFDVFLRFMCHHAVRIRGKsYVQCQGIPQGSILSTLLCSL
O14757	S280	SIGNOR\|ELM	CHEK1 CHK1	KKDRWYNKPLKKGAKRPRVtsGGVsEsPsGFsKHIQsNLDF
O14776	T746	Sugiyama	TCERG1 CA150 TAF2S	MQAKEDFKKMMEEAKFNPRAtFSEFAAKHAKDSRFKAIEKM
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15013	S1287	Sugiyama	ARHGEF10 KIAA0294	WLGDSLGSMTQKsDLssssGsLsLsHGsssLEHRSEDsTIy
O15111	T23	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHUK IKKA TCF16	RPPGLRPGAGGPWEMRERLGtGGFGNVCLYQHRELDLKIAI
O15119	S719	SIGNOR	TBX3	LSsssMsLsPKLCAEKEAATsELQsIQRLVSGLEAKPDRsR
O15143	S328	Sugiyama	ARPC1B ARC41	KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT
O15151	S367	SIGNOR	MDM4 MDMX	tAIPEKENEGNDVPDCRRtIsAPVVRPKDAYIKKENSKLFD
O15360	S1149	SIGNOR\|ELM	FANCA FAA FACA FANCH	DITAHFFRGLLNACLRSRDPsLMVDFILAKCQTKCPLILTS
O15519	S273	SIGNOR	CFLAR CASH CASP8AP1 CLARP MRIT	ICLIIDCIGNETELLRDTFTsLGYEVQKFLHLSMHGISQIL
O43390	T137	Sugiyama	HNRNPR HNRPR	ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43464	S212	SIGNOR\|EPSD\|PSP	HTRA2 OMI PRSS25	LIVTNAHVVADRRRVRVRLLsGDtYEAVVTAVDPVADIATL
O43516	S154	EPSD\|PSP	WIPF1 WASPIP WIP	RSTsAKPFsPPSGPGRFPVPsPGHRSGPPEPQRNRMPPPRP
O43516	T398	EPSD\|PSP	WIPF1 WASPIP WIP	PLPPPPPVSRNGSTSRALPAtPQLPSRSGVDsPRsGPRPPL
O43521	S87	SIGNOR	BCL2L11 BIM	PAsPGPFATRsPLFIFMRRSsLLSRsssGYFsFDTDRsPAP
O43524	S253	SIGNOR\|ELM	FOXO3 FKHRL1 FOXO3A	WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524	S315	SIGNOR	FOXO3 FKHRL1 FOXO3A	PtSRssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDE
O43524	T32	SIGNOR\|ELM	FOXO3 FKHRL1 FOXO3A	sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O43707	T69	Sugiyama	ACTN4	EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O60285	S600	SIGNOR\|ELM	NUAK1 ARK5 KIAA0537 OMPHK1	SDSFDLLDLQENRPARQRIRsCVsAENFLQIQDFEGLQNRP
O60293	S42	Sugiyama	ZFC3H1 CCDC131 KIAA0546 PSRC2	LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60331	S555	EPSD\|PSP	PIP5K1C KIAA0589	IPERSPsETSEQPRYRRRtQssGQDGRPQEEPPAEEDLQQI
O60343	S588	SIGNOR\|Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60343	T642	SIGNOR\|ELM	TBC1D4 AS160 KIAA0603	AWQTFPEEDSDSPQFRRRAHtFsHPPsstKRKLNLQDGRAQ
O60343	T749	Sugiyama	TBC1D4 AS160 KIAA0603	ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60343	T752	Sugiyama	TBC1D4 AS160 KIAA0603	IRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISW
O60506	T134	Sugiyama	SYNCRIP HNRPQ NSAP1	DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60825	S466	SIGNOR\|ELM	PFKFB2	RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O60825	S483	SIGNOR\|ELM	PFKFB2	RRNsFtPLsssNtIRRPRNYsVGsRPLKPLsPLRAQDMQEG
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S183	Sugiyama	EIF5B IF2 KIAA0741	GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O75369	S1442	Sugiyama	FLNB FLN1L FLN3 TABP TAP	SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75376	S1450	SIGNOR	NCOR1 KIAA1047	VERGKYEDVKAGETVRSRHtsVVsSGPSVLRSTLHEAPKAQ
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75937	S81	Sugiyama	DNAJC8 SPF31 HSPC315 HSPC331	VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O94992	T270	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95453	S557	Sugiyama	PARN DAN	KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95835	S464	Sugiyama	LATS1 WARTS	SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00533	S229	PSP	EGFR ERBB ERBB1 HER1	KLTKIICAQQCSGRCRGKSPsDCCHNQCAAGCTGPRESDCL
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P03372	S104	SIGNOR	ESR1 ESR NR3A1	SEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPH
P03372	S106	SIGNOR	ESR1 ESR NR3A1	AAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQ
P03372	S118	SIGNOR	ESR1 ESR NR3A1	PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P03372	S167	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ESR1 ESR NR3A1	PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P04040	T434	Sugiyama	CAT	QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE
P04049	S259	SIGNOR\|ELM	RAF1 RAF	tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S182	Sugiyama	ANXA1 ANX1 LPC1	RDLAKDItsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsD
P04150	S134	SIGNOR	NR3C1 GRL	SGETDLKLLEEsIANLNRstsVPENPKSSASTAVSAAPTEK
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	EPSD\|PSP	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	SIGNOR\|Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05106	T779	SIGNOR	ITGB3 GP3A	ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07550	S345	SIGNOR	ADRB2 ADRB2R B2AR	IyCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsG
P07550	S346	SIGNOR\|ELM	ADRB2 ADRB2R B2AR	yCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsGY
P07814	S1336	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN
P07814	S999	PSP	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	QKQNDGQRKDPsKNQGGGLsssGAGEGQGPKKQTRLGLEAK
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08174	T102	Sugiyama	CD55 CR DAF	LKGSQWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVG
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S452	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08670	S39	SIGNOR	VIM	GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758	T8	Sugiyama	ANXA5 ANX5 ENX2 PP4	_____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09601	S188	SIGNOR	HMOX1 HO HO1	TFPNIASATKFKQLYRSRMNsLEMTPAVRQRVIEEAKTAFL
P09651	S199	SIGNOR	HNRNPA1 HNRPA1	KALSKQEMAsAsssQRGRsGsGNFGGGRGGGFGGNDNFGRG
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0C0L4	S1567	Sugiyama	C4A CO4 CPAMD2	GLVQPASATLYDYYNPERRCsVFYGAPSKSRLLATLCSAEV
P0C0L5	S1567	Sugiyama	C4B CO4 CPAMD3; C4B_2	GLVQPASATLYDYYNPERRCsVFYGAPSKSRLLATLCSAEV
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10275	S215	SIGNOR	AR DHTR NR3C4	QQQQQEAVSEGssSGRAREAsGAPTsSKDNyLGGTSTISDN
P10275	S792	SIGNOR	AR DHTR NR3C4	NEYRMHKSRMYSQCVRMRHLsQEFGWLQITPQEFLCMKALL
P10276	S96	SIGNOR	RARA NR1B1	PsPPPLPRIYKPCFVCQDKSsGYHYGVSACEGCKGFFRRSI
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12755	T458	SIGNOR	SKI	AVSRAPEPLATCTQPRKRKLtVDTPGAPETLAPVAAPEEDK
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13674	T364	Sugiyama	P4HA1 P4HA	IsDAEIEIVKDLAKPRLRRAtIsNPITGDLETVHYRISKsA
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14598	S304	SIGNOR\|ELM	NCF1 NOXO2 SH3PXD1A	GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598	S328	SIGNOR\|ELM	NCF1 NOXO2 SH3PXD1A	AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15056	S364	SIGNOR	BRAF BRAF1 RAFB1	QPFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIR
P15056	S365	ELM	BRAF BRAF1 RAFB1	PFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIRD
P15056	S428	SIGNOR	BRAF BRAF1 RAFB1	GSLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssD
P15056	S429	ELM	BRAF BRAF1 RAFB1	SLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssDD
P15056	T440	SIGNOR	BRAF BRAF1 RAFB1	PGPQRERKsssssEDRNRMKtLGRRDssDDWEIPDGQITVG
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15311	T567	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	EZR VIL2	RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15880	S190	Sugiyama	RPS2 RPS4	WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P15880	T232	Sugiyama	RPS2 RPS4	KLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysyLt
P15976	S310	SIGNOR\|ELM	GATA1 ERYF1 GF1	QVNRPLTMRKDGIQTRNRKAsGKGKKKRGSSLGGTGAAEGP
P16220	S119	SIGNOR	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16930	S165	Sugiyama	FAH	ENALMPNWLHLPVGYHGRAssVVVSGTPIRRPMGQMKPDDS
P17542	T90	SIGNOR	TAL1 BHLHA17 SCL TCL5	AARDLKGRDAATAEARHRVPtTELCRPPGPAPAPAPASVTA
P17655	T464	Sugiyama	CAPN2 CANPL2	TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P18031	S50	SIGNOR\|ELM	PTPN1 PTP1B	FPCRVAKLPKNKNRNRyRDVsPFDHSRIKLHQEDNDyINAs
P18583	S2011	Sugiyama	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	RSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20749	S41	SIGNOR	BCL3 BCL4 D19S37	KAAGLPGAALPLRKRPLRAPsPEPAAPRGAAGLVVPLDPLR
P21453	T236	SIGNOR\|ELM	S1PR1 CHEDG1 EDG1	SIVILYCRIYSLVRTRSRRLtFRKNISKASRSSEKSLALLK
P21731	S331	Sugiyama	TBXA2R	FRRAVLRRLQPRLsTRPRsLsLQPQLtQRSGLQ________
P22059	S190	Sugiyama	OSBP OSBP1	QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22736	S351	SIGNOR\|ELM	NR4A1 GFRP1 HMR NAK1	GMVKEVVRTDsLKGRRGRLPsKPKQPPDAsPANLLtSLVRA
P23396	T70	SIGNOR	RPS3 OK/SW-cl.26	ILATRTQNVLGEKGRRIRELtAVVQKRFGFPEGsVELyAEK
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S422	SIGNOR	EIF4B	ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs
P23769	S401	SIGNOR	GATA2	NVNRPLTMKKEGIQTRNRKMsNKSKKSKKGAECFEELSKCM
P24941	T39	SIGNOR	CDK2 CDKN2	yKARNKLTGEVVALKKIRLDtETEGVPstAIREIsLLKELN
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25205	S447	Sugiyama	MCM3	EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P26358	S143	SIGNOR	DNMT1 AIM CXXC9 DNMT	ADANsPPKPLSKPRTPRRsKsDGEAKPEPsPsPRITRKSTR
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P26678	T17	SIGNOR	PLN PLB	____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFCL
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29401	T382	SIGNOR	TKT	CYIAEQNMVSIAVGCATRNRtVPFCsTFAAFFTRAFDQIRM
P29474	S1177	SIGNOR\|ELM	NOS3	EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474	S1179	ELM	NOS3	IFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPGSD
P29474	S615	SIGNOR\|ELM	NOS3	GPYNSsPRPEQHKSYKIRFNsISCSDPLVssWRRKRKEssN
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30405	S31	SIGNOR\|EPSD\|PSP	PPIF CYP3	LGLLSVPRSVPLRLPAARACsKGSGDPSssSSSGNPLVYLD
P31323	S114	ELM	PRKAR2B	APADAGAFNAPVINRFTRRAsVCAEAyNPDEEEDDAESRII
P31749	T312	Sugiyama	AKT1 PKB RAC	DFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31751	S126	Sugiyama	AKT2	VANSLKQRAPGEDPMDyKCGsPsDssttEEMEVAVSKARAK
P31751	S128	Sugiyama	AKT2	NSLKQRAPGEDPMDyKCGsPsDssttEEMEVAVSKARAKVT
P31751	S130	Sugiyama	AKT2	LKQRAPGEDPMDyKCGsPsDssttEEMEVAVSKARAKVTMN
P31751	S131	Sugiyama	AKT2	KQRAPGEDPMDyKCGsPsDssttEEMEVAVSKARAKVTMND
P31751	S474	Sugiyama	AKT2	DRyDsLGLLELDQRTHFPQFsysAsIRE_____________
P31751	S476	Sugiyama	AKT2	yDsLGLLELDQRTHFPQFsysAsIRE_______________
P31751	S478	Sugiyama	AKT2	sLGLLELDQRTHFPQFsysAsIRE_________________
P31751	T313	Sugiyama	AKT2	DFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31751	Y475	Sugiyama	AKT2	RyDsLGLLELDQRTHFPQFsysAsIRE______________
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35222	S552	SIGNOR\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35226	S316	SIGNOR\|PSP	BMI1 PCGF4 RNF51	TSNSPSGNHQSSFANRPRKSsVNGSSATSSG__________
P35240	S10	PSP	NF2 SCH	___________MAGAIASRMsFssLKRKQPKTFTVRIVTMD
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269	T156	Sugiyama	GTF2F1 RAP74	EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38398	S694	SIGNOR	BRCA1 RNF53	PATGAKKSNKPNEQTSKRHDsDTFPELKLTNAPGsFtKCSN
P38398	T509	SIGNOR\|ELM	BRCA1 RNF53	EPQIIQERPLTNKLKRKRRPtsGLHPEDFIKKADLAVQKTP
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T111	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38936	S146	ELM	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P38936	T145	SIGNOR\|ELM	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	EQAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40926	T179	Sugiyama	MDH2	GVYNPNKIFGVTTLDIVRANtFVAELKGLDPARVNVPVIGG
P41002	S577	SIGNOR	CCNF FBX1 FBXO1	EIHAFLSSPSGRRTKRKRENsLQEDRGSFVTtPtAELSSQE
P41002	T31	SIGNOR	CCNF FBX1 FBXO1	CAKCFCYPTKRRIRRRPRNLtILSLPEDVLFHILKWLSVED
P41219	S59	SIGNOR	PRPH NEF4 PRPH1	RFSSSRLLGsAsPsssVRLGsFRSPRAGAGALLRLPSERLD
P41279	S400	SIGNOR\|ELM	MAP3K8 COT ESTF	ADLLKHEALNPPREDQPRCQsLDSALLERKRLLsRKELELP
P41279	S413	SIGNOR	MAP3K8 COT ESTF	EDQPRCQsLDSALLERKRLLsRKELELPENIADSSCTGSTE
P42345	S2448	SIGNOR\|ELM	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH
P42345	T2446	SIGNOR\|ELM	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42858	S419	SIGNOR	HTT HD IT15	GGIGQLtAAKEEsGGRsRsGsIVELIAGGGssCsPVLsRKQ
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S234	Sugiyama	MATR3 KIAA0723	yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45985	S80	SIGNOR\|ELM	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	tLNPNPtGVQNPHIERLRTHsIEsSGKLKIsPEQHWDFtAE
P46527	S10	ELM	CDKN1B KIP1 p27	___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P46527	T157	SIGNOR\|ELM	CDKN1B KIP1 p27	PsDsQTGLAEQCAGIRKRPAtDDSSTQNKRANRTEENVsDG
P46527	T198	SIGNOR	CDKN1B KIP1 p27	sPNAGSVEQtPKKPGLRRRQt____________________
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46937	S127	SIGNOR\|ELM	YAP1 YAP65	QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47870	S472	SIGNOR	GABRB2	GRNALERHVAQKKSRLRRRAsQLKITIPDLTDVNAIDRWSR
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49753	T118	Sugiyama	ACOT2 PTE2 PTE2A	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
P49760	S34	SIGNOR	CLK2	SRGSYREHYRSRKHKRRRSRsWSSSSDRTRRRRREDsYHVR
P49760	T127	SIGNOR	CLK2	SYRSQRSSRRKHRRRRRRSRtFSRSSSQHSSRRAKsVEDDA
P49815	S939	SIGNOR\|ELM	TSC2 TSC4	NVLLsFDDtPEKDsFRARsTsLNERPKSLRIARPPKQGLNN
P49815	T1462	SIGNOR\|ELM	TSC2 TSC4	EGPLPsssPRsPsGLRPRGYtIsDsAPsRRGKRVERDALKS
P49840	S21	SIGNOR\|ELM\|Sugiyama	GSK3A	MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841	S9	SIGNOR	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49918	S282	SIGNOR	CDKN1C KIP2	AAIKKLSGPLISDFFAKRKRsAPEKssGDVPAPCPsPsAAP
P49918	T310	SIGNOR	CDKN1C KIP2	DVPAPCPsPsAAPGVGSVEQtPRKRLR______________
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51617	T100	SIGNOR\|ELM	IRAK1 IRAK	VADLVHILTHLQLLRARDIItAWHPPAPLPSPGTTAPRPSS
P51946	T12	Sugiyama	CCNH	_________MYHNsSQKRHWtFSsEEQLARLRADANRKFRC
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52789	T473	SIGNOR	HK2	AAMVTAVAYRLADQHRARQKtLEHLQLSHDQLLEVKRRMKV
P53365	S260	SIGNOR\|Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396	S455	SIGNOR\|EPSD\|Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396	S459	Sugiyama	ACLY	LNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQDsV
P53621	T591	Sugiyama	COPA	TRVKGNNVyCLDRECRPRVLtIDPTEFKFKLALINRKYDEV
P53804	S378	GPS6\|SIGNOR	TTC3 DCRR1 RNF105 TPRD	ANKDPIKAFYENRAYTPRsLsAPIFTTSLNFVEKERDFRKI
P54253	S775	SIGNOR	ATXN1 ATX1 SCA1	APFLTKIEPSKPAATRKRRWsAPESRKLEKSEDEPPLTLPK
P54578	S432	SIGNOR	USP14 TGT	SNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFDD
P55072	S352	SIGNOR	VCP HEL-220 HEL-S-70	MDGLKQRAHVIVMAAtNRPNsIDPALRRFGRFDREVDIGIP
P55072	S746	SIGNOR	VCP HEL-220 HEL-S-70	DPVPEIRRDHFEEAMRFARRsVsDNDIRKyEMFAQtLQQsR
P55072	S748	SIGNOR	VCP HEL-220 HEL-S-70	VPEIRRDHFEEAMRFARRsVsDNDIRKyEMFAQtLQQsRGF
P55196	S216	Sugiyama	AFDN AF6 MLLT4	SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55199	S47	Sugiyama	ELL C19orf17	HVKLTDSALRAFESYRARQDsVSLRPSIRFQGSQGHISIPQ
P55211	S196	SIGNOR\|ELM	CASP9 MCH6	GLRTRTGsNIDCEKLRRRFssLHFMVEVKGDLTAKKMVLAL
P55265	T1033	SIGNOR\|PSP	ADAR ADAR1 DSRAD G1P1 IFI4	VESSDIVPTWDGIRLGERLRtMSCSDKILRWNVLGLQGALL
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57059	S435	SIGNOR	SIK1 SIK SNF1LK	WPLFFPVDASCSGVFRPRPVsPssLLDTAISEEARQGPGLE
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353	S86	Sugiyama	RPL27	SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62280	S74	Sugiyama	RPS11	tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62333	S244	Sugiyama	PSMC6 SUG2	DHQPCIIFMDEIDAIGGRRFsEGTSADREIQRTLMELLNQM
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62826	T32	Sugiyama	RAN ARA24 OK/SW-cl.81	KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63000	S71	SIGNOR\|ELM	RAC1 TC25 MIG5	VNLGLWDTAGQEDyDRLRPLsYPQTDVFLICFSLVSPASFE
P63104	S58	SIGNOR\|ELM	YWHAZ	NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P67809	S102	SIGNOR	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68400	T13	Sugiyama	CSNK2A1 CK2A1	________MSGPVPSRARVytDVNTHRPREYWDYESHVVEW
P68431	S11	EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431	S29	EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	RKstGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
P68431	T46	EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78362	S494	Sugiyama	SRPK2	GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P78362	T492	SIGNOR	SRPK2	SEGSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLL
P78371	S260	SIGNOR	CCT2 99D8.1 CCTB	ANtGMDtDKIKIFGsRVRVDstAKVAEIEHAEKEKMKEKVE
P78563	T553	SIGNOR\|PSP	ADARB1 ADAR2 DRADA2 RED1	VRSNASIQTWDGVLQGERLLtMSCSDKIARWNVVGIQGSLL
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243	S11	SIGNOR	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	__________MARtKQTARKstGGKAPRKQLATKAARKsAP
P98170	S87	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	XIAP API3 BIRC4 IAP3	HAAVDRWQYGDSAVGRHRKVsPNCRFINGFYLENSATQSTN
P98177	S197	SIGNOR\|ELM	FOXO4 AFX AFX1 MLLT7	WWMLNPEGGKSGKAPRRRAAsMDSSSKLLRGRSKAPKKKPS
P98177	S262	SIGNOR\|ELM	FOXO4 AFX AFX1 MLLT7	PCSRNREEADMWTTFRPRSSsNAsSVsTRLSPLRPESEVLA
P98177	T32	SIGNOR\|iPTMNet	FOXO4 AFX AFX1 MLLT7	AAAIIDLDPDFEPQSRPRsCtWPLPRPEIANQPSEPPEVEP
P98177	T451	ELM	FOXO4 AFX AFX1 MLLT7	LSMIAPPPVMASAPIPKALGtPVLtPPTEAASQDRMPQDLD
P99999	Y47	SIGNOR\|PSP	CYCS CYC	HKTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLME
Q00266	S180	PSP	MAT1A AMS1 MATA1	LNARMADLRRSGLLPWLRPDsKTQVTVQYMQDNGAVIPVRI
Q00266	T202	PSP	MAT1A AMS1 MATA1	TQVTVQYMQDNGAVIPVRIHtIVISVQHNEDITLEEMRRAL
Q00610	S146	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00610	S147	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00613	S230	PSP	HSF1 HSTF1	PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q00613	S326	PSP	HSF1 HSTF1	QsPRVEEAsPGRPssVDtLLsPtALIDsILREsEPAPAsVT
Q00987	S166	SIGNOR\|ELM	MDM2	KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q00987	S186	SIGNOR\|ELM	MDM2	sEtEENsDELsGERQRKRHKsDsISLsFDESLALCVIREIC
Q00987	S188	SIGNOR\|ELM	MDM2	tEENsDELsGERQRKRHKsDsISLsFDESLALCVIREICCE
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01860	T235	SIGNOR	POU5F1 OCT3 OCT4 OTF3	ENLQEICKAETLVQARKRKRtsIENRVRGNLENLFLQCPKP
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04656	S1424	SIGNOR\|EPSD\|PSP	ATP7A MC1 MNK	SLFLKLYRKPTYESYELPARsQIGQKsPsEIsVHVGIDDts
Q04656	S1463	SIGNOR\|EPSD\|PSP	ATP7A MC1 MNK	tsRNsPKLGLLDRIVNYsRAsINsLLsDKRsLNsVVTsEPD
Q04656	S1466	SIGNOR\|EPSD\|PSP	ATP7A MC1 MNK	NsPKLGLLDRIVNYsRAsINsLLsDKRsLNsVVTsEPDKHS
Q04912	S1394	SIGNOR\|ELM	MST1R PTK8 RON	RPEQPQFSPMPGNVRRPRPLsEPPRPT______________
Q05195	S145	SIGNOR	MXD1 MAD	EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07020	T136	Sugiyama	RPL18	AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07352	S92	SIGNOR\|ELM	ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B	KGEPAPALSSRDsRFRDRsFsEGGERLLPTQKQPGGGQVNS
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07812	S184	SIGNOR	BAX BCL2L4	YFGtPTWQtVtIFVAGVLTAsLtIWKKMG____________
Q09472	S1834	SIGNOR\|ELM	EP300 P300	RQQQLQHRLQQAQMLRRRMAsMQRTGVVGQQQGLPSPTPAT
Q12778	S256	SIGNOR\|ELM	FOXO1 FKHR FOXO1A	WWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSRAAKKKAs
Q12778	S319	SIGNOR\|ELM	FOXO1 FKHR FOXO1A	PGsHsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLG
Q12778	S322	ELM	FOXO1 FKHR FOXO1A	HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778	S325	ELM	FOXO1 FKHR FOXO1A	DDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHS
Q12778	T24	SIGNOR\|ELM\|EPSD	FOXO1 FKHR FOXO1A	APQVVEIDPDFEPLPRPRsCtWPLPRPEFSQSNSATSSPAP
Q12906	S647	SIGNOR	ILF3 DRBF MPHOSPH4 NF90	GPMHNEVPPPPNLRGRGRGGsIRGRGRGRGFGGANHGGYMN
Q12931	T494	Sugiyama	TRAP1 HSP75 HSPC5	ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q12965	Y941	Sugiyama	MYO1E MYO1C	GPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPPGy
Q12982	S114	Sugiyama	BNIP2 NIP2	EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13043	T120	SIGNOR	STK4 KRS2 MST1	IVMEYCGAGSVSDIIRLRNKtLtEDEIAtILQStLKGLEYL
Q13043	T387	SIGNOR	STK4 KRS2 MST1	tMVINAEDEEEEGtMKRRDEtMQPAKPsFLEyFEQKEKENQ
Q13188	T117	SIGNOR	STK3 KRS1 MST2	IVMEYCGAGSVSDIIRLRNKtLIEDEIATILKSTLKGLEYL
Q13188	T384	SIGNOR	STK3 KRS1 MST2	TMVINSEDEEEEDGtMKRNAtsPQVQRPsFMDyFDKQDFKN
Q13243	S86	SIGNOR	SRSF5 HRS SFRS5 SRP40	RVTIEHARARSRGGRGRGRYsDRFsSRRPRNDRRNAPPVRT
Q13370	S295	SIGNOR	PDE3B	HPRLssAAEEKVPVIRPRRRssCVsLGETAASYYGSCKIFR
Q13370	S318	SIGNOR	PDE3B	VsLGETAASYYGSCKIFRRPsLPCISREQMILWDWDLKQWY
Q13439	S41	Sugiyama	GOLGA4	APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13464	S479	Sugiyama	ROCK1	KLDKIMKELDEEGNQRRNLEsTVsQIEKEKMLLQHRINEYQ
Q13480	T387	Sugiyama	GAB1	sDTDssyCIPtAGMsPSRSNtIstVDLNKLRKDAssQDCyD
Q13610	S485	Sugiyama	PWP1	SVNEAFGRRERLVLGSARNssISGPFGsRssDTPMES____
Q13835	S118	SIGNOR\|PSP	PKP1	SWGYPIyNGTLKREPDNRRFssysQMENWsRHYPRGsCNTT
Q13835	S119	PSP	PKP1	WGYPIyNGTLKREPDNRRFssysQMENWsRHYPRGsCNTTG
Q13835	S121	PSP	PKP1	YPIyNGTLKREPDNRRFssysQMENWsRHYPRGsCNTTGAG
Q13835	S127	PSP	PKP1	TLKREPDNRRFssysQMENWsRHYPRGsCNTTGAGsDICFM
Q13835	S174	SIGNOR\|PSP	PKP1	RsEPDLyCDPRGtLRKGtLGsKGQKttQNRysFystCsGQK
Q13835	S185	SIGNOR\|PSP	PKP1	GtLRKGtLGsKGQKttQNRysFystCsGQKAIKKCPVRPPs
Q13835	S188	SIGNOR\|PSP	PKP1	RKGtLGsKGQKttQNRysFystCsGQKAIKKCPVRPPsCAs
Q13835	S191	SIGNOR\|PSP	PKP1	tLGsKGQKttQNRysFystCsGQKAIKKCPVRPPsCAsKQD
Q13835	S54	PSP	PKP1	GTSGRQRVQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGL
Q13835	S56	PSP	PKP1	SGRQRVQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGLAD
Q13835	S57	PSP	PKP1	GRQRVQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGLADN
Q13835	S59	PSP	PKP1	QRVQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGLADNyN
Q13835	S60	PSP	PKP1	RVQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGLADNyNy
Q13835	S63	PSP	PKP1	EQVMMTVKRQKsKssQsstLsHsNRGsMyDGLADNyNyGtT
Q13835	S65	PSP	PKP1	VMMTVKRQKsKssQsstLsHsNRGsMyDGLADNyNyGtTsR
Q13835	S69	PSP	PKP1	VKRQKsKssQsstLsHsNRGsMyDGLADNyNyGtTsRSSYY
Q13835	S84	PSP	PKP1	HsNRGsMyDGLADNyNyGtTsRSSYYSKFQAGNGSWGYPIy
Q13835	T166	SIGNOR\|PSP	PKP1	FMQKIKAsRsEPDLyCDPRGtLRKGtLGsKGQKttQNRysF
Q13835	T171	SIGNOR\|PSP	PKP1	KAsRsEPDLyCDPRGtLRKGtLGsKGQKttQNRysFystCs
Q13835	T179	SIGNOR\|PSP	PKP1	LyCDPRGtLRKGtLGsKGQKttQNRysFystCsGQKAIKKC
Q13835	T180	SIGNOR\|PSP	PKP1	yCDPRGtLRKGtLGsKGQKttQNRysFystCsGQKAIKKCP
Q13835	T189	SIGNOR\|PSP	PKP1	KGtLGsKGQKttQNRysFystCsGQKAIKKCPVRPPsCAsK
Q13835	T61	PSP	PKP1	VQEQVMMTVKRQKsKssQsstLsHsNRGsMyDGLADNyNyG
Q13835	T82	PSP	PKP1	LsHsNRGsMyDGLADNyNyGtTsRSSYYSKFQAGNGSWGYP
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14153	S167	Sugiyama	FAM53B KIAA0140 SMP	YsGGsVQRYSNGFSTMQRsssFSLPSRANVLssPCDQAGLH
Q14204	S4162	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL
Q14204	S4368	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	MLEDEDDLAyAETEKKTRtDstsDGRPAWMRTLHTTASNWL
Q14315	S2233	SIGNOR\|EPSD\|PSP	FLNC ABPL FLN2	VGGDPFPAVFGDFLGRERLGsFGsITRQQEGEAsSQDMTAQ
Q14566	S498	Sugiyama	MCM6	EQQTISITKAGVKATLNARTsILAAANPIsGHyDRSKSLKQ
Q14653	S14	PSP	IRF3	_______MGTPKPRILPWLVsQLDLGQLEGVAWVNKSRTRF
Q14653	S175	PSP	IRF3	PGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRL
Q14653	T180	PSP	IRF3	LAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRLLVPGE
Q14653	T207	PSP	IRF3	PsENPLKRLLVPGEEWEFEVtAFYRGRQVFQQTISCPEGLR
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14847	S146	Sugiyama	LASP1 MLN50	FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14957	S1081	SIGNOR	GRIN2C NMDAR2C	ARREALLHAAWARGSRPRHAsLPSSVAEAFARPSSLPAGCT
Q14978	S686	Sugiyama	NOLC1 KIAA0035 NS5ATP13	KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15027	S554	SIGNOR\|ELM	ACAP1 CENTB1 KIAA0050	GRPRGQPPVPPKPSIRPRPGsLRSKPEPPSEDLGSLHPGAL
Q15084	S377	Sugiyama	PDIA6 ERP5 P5 TXNDC7	PAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGstAP
Q15118	T346	SIGNOR\|EPSD\|PSP	PDK1 PDHK1	RKIDRLFNYMYStAPRPRVEtSRAVPLAGFGYGLPISRLYA
Q15121	S116	SIGNOR\|ELM	PEA15	DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15149	S4386	Sugiyama	PLEC PLEC1	ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15365	S43	SIGNOR	PCBP1	KEVGsIIGKKGESVKRIREEsGARINIsEGNCPERIItLTG
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15672	S42	SIGNOR	TWIST1 BHLHA38 TWIST	EEPDRQQPPSGKRGGRKRRSsRRSAGGGAGPGGAAGGGVGG
Q15910	S21	SIGNOR	EZH2 KMT6	MGQTGKKSEKGPVCWRKRVKsEYMRLRQLKRFRRADEVKSM
Q15942	S142	SIGNOR	ZYX	EEEGGPEAPIPPPPQPREKVssIDLEIDsLssLLDDMTKND
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16584	S674	SIGNOR\|ELM	MAP3K11 MLK3 PTK1 SPRK	sLGLGRDLQPPGGPGRERGEsPTTPPTPTPAPCPTEPPPsP
Q16658	T403	PSP	FSCN1 FAN1 HSN SNL	RPIIVFRGEHGFIGCRKVTGtLDANRSSyDVFQLEFNDGAy
Q16763	T152	Sugiyama	UBE2S E2EPF OK/SW-cl.73	EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA
Q16875	S461	SIGNOR	PFKFB3	THRERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEE
Q2PPJ7	S486	SIGNOR	RALGAPA2 C20orf74 KIAA1272	KEASSESSGHKRSSsWGRtYsFTSAMSRGCVTEEENTNVKA
Q2PPJ7	S696	SIGNOR	RALGAPA2 C20orf74 KIAA1272	QRGKGCVLDPQKGTTVGRSFsLSWRsHPDVTEPMRFRSAtT
Q2PPJ7	T715	SIGNOR	RALGAPA2 C20orf74 KIAA1272	FsLSWRsHPDVTEPMRFRSAtTsGAPGVEKARNIVRQKATE
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3V6T2	S1417	SIGNOR	CCDC88A APE GRDN KIAA1212	TLKMRKLIKSKKDINRERQKsLtLtPtRsDssEGFLQLPHQ
Q53EL6	S457	SIGNOR\|ELM	PDCD4 H731	GIISKQLRDLCPSRGRKRFVsEGDGGRLKPESY________
Q53EL6	S67	SIGNOR\|ELM	PDCD4 H731	AssINEARINAKAKRRLRKNssRDsGRGDsVsDsGsDALRS
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5SSJ5	S227	Sugiyama	HP1BP3	LKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRKNR
Q5SW79	S881	Sugiyama	CEP170 FAM68A KAB KIAA0470	sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5TAX3	S1384	Sugiyama	TUT4 KIAA0191 ZCCHC11	DAGHVRRECPEVKLARQRNssVAAAQLVRNLVNAQQVAGSA
Q5UE93	T607	SIGNOR	PIK3R6 C17orf38	GAELSLCYQKALLSHRPREVtVSLRATGLILKAIPASDTEV
Q5VTB9	T368	Sugiyama	RNF220 C1orf164	ENNNRFEEYEWCGQKRIRATtLLEGGFRGSGFIMCSGKENP
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q63ZY3	S540	Sugiyama	KANK2 ANKRD25 KIAA1518 MXRA3 SIP	NIsDNDSTENEAPEPRERVPsVAEAPQLRPAGTAAAKTSRQ
Q69YN4	S1432	Sugiyama	VIRMA KIAA1429 MSTP054	CCGDDNGLMEVEGAHTSRTMsINAAELKQLLQSKEESPENL
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6P6C2	S96	Sugiyama	ALKBH5 ABH5 OFOXD1	LQKEEEARKVKSGIRQMRLFsQDECAKIEARIDEVVSRAEK
Q6PJT7	S327	Sugiyama	ZC3H14	KFNHDGEEEEEDDDYGSRtGsISsSVSVPAKPERRPsLPPS
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6U7Q0	S224	SIGNOR	ZNF322 ZNF322A ZNF388 ZNF489	THTGERPYKCNKCEKSYRHRsAFIVHKRVHtGEKPYKCGAC
Q6U7Q0	T150	SIGNOR	ZNF322 ZNF322A ZNF388 ZNF489	DICGKNFGQSSDLLVHQRSHtGEKPYLCSECDKCFSRSTNL
Q6U7Q0	T234	SIGNOR	ZNF322 ZNF322A ZNF388 ZNF489	NKCEKSYRHRsAFIVHKRVHtGEKPYKCGACEKCFGQKSDL
Q6U7Q0	T262	SIGNOR	ZNF322 ZNF322A ZNF388 ZNF489	GACEKCFGQKSDLIVHQRVHtGEKPYKCLECMRSFTRSANL
Q6ZWJ1	S99	SIGNOR	STXBP4	IGVsFEEAKSIITGAKLRLEsAWEIAFIRQKSDNIQPENLS
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7L5N1	S60	SIGNOR	COPS6 CSN6 HVIP	SVALHPLVILNISDHWIRMRsQEGRPVQVIGALIGKQEGRN
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5	S454	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5H3	S16	SIGNOR	ARHGAP22 RHOGAP2	_____MLSPKIRQARRARsKsLVMGEQSRSPGRMPCPHRLG
Q7Z5L9	S457	Sugiyama	IRF2BP2	GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q7Z6J0	S125	GPS6	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	ANCSSKDLQSSQGGQQPRVQsWsPPVRGIPQLPCAKALYNY
Q7Z6J0	S304	SIGNOR\|EPSD\|PSP	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	AQSSTAPKHSDTKKNTKKRHsFTSLTMANKssQAsQNRHsM
Q7Z6J0	S800	GPS6	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	PVTTAVAGAALAQDAFHRKAssLDSAVPIAPPPRQACSSLG
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86SQ0	S417	Sugiyama	PHLDB2 LL5B	SLRQAsGtPQPALRERKssIssISGRDDLMDYHRRQREERL
Q86SQ0	S418	Sugiyama	PHLDB2 LL5B	LRQAsGtPQPALRERKssIssISGRDDLMDYHRRQREERLR
Q86TX2	T56	Sugiyama	ACOT1 CTE1	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
Q86V81	T219	SIGNOR	ALYREF ALY BEF THOC4	GMTRNRGAGGFGGGGGTRRGtRGGARGRGRGAGRNSKQQLs
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q86YS7	S197	EPSD\|PSP	C2CD5 CDP138 KIAA0528	QWIDRIRTPRASNEARQRLIsLMsGELQRKIGLKVLEMRGN
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IZ21	S590	Sugiyama	PHACTR4 PRO2963	SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N9L9	S392	SIGNOR	ACOT4 PTE2B PTEIB	ASLHRLLNKHVIWGGEPRAHsKAQEDAWKQILAFFCKHLGG
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBP7	S487	Sugiyama	PCSK9 NARC1 PSEC0052	PTRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKL
Q8NCD3	S486	SIGNOR	HJURP FAKTS FLEG1 URLC9	MYRGGPAsPGGLQGLETRRLsLPSSKAKAKsLSEAFENLGK
Q8TAP6	S571	Sugiyama	CEP76 C18orf9	DQLSYLLSPALASYEFERTTsISAGNEEFQDAIRRAVPDGH
Q8TD19	T333	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TE77	S37	Sugiyama	SSH3 SSH3L	tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8WWI1	T932	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q8WX93	S1118	SIGNOR	PALLD KIAA0992 CGI-151	RGRsPRsPsGHPHVRRPRsRsRDsGDENEPIQERFFRPHFL
Q8WX93	S726	Sugiyama	PALLD KIAA0992 CGI-151	PAsPEPMSALASRsAPAMQssGsFNyARPKQFIAAQNLGPA
Q8WX93	S728	Sugiyama	PALLD KIAA0992 CGI-151	sPEPMSALASRsAPAMQssGsFNyARPKQFIAAQNLGPAsG
Q92597	S330	Sugiyama	NDRG1 CAP43 DRG1 RTP	QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92597	S367	Sugiyama	NDRG1 CAP43 DRG1 RTP	SEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAGP
Q92614	T228	Sugiyama	MYO18A CD245 KIAA0216 MYSPDZ TIAF1	PPVVPLPPPTLRELELQRRPtGDFGFsLRRTTMLDRGPEGQ
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92879	S28	SIGNOR	CELF1 BRUNOL2 CUGBP CUGBP1 NAB50	PDQPDLDAIKMFVGQVPRtWsEKDLRELFEQYGAVYEINVL
Q92900	T151	SIGNOR\|PSP	UPF1 KIAA0221 RENT1	PACVVYCNTSKKWFCNGRGNtSGSHIVNHLVRAKCKEVTLH
Q92934	S118	SIGNOR	BAD BBC6 BCL2L8	RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934	S75	SIGNOR	BAD BBC6 BCL2L8	PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934	S99	SIGNOR\|ELM	BAD BBC6 BCL2L8	GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q92945	S193	SIGNOR\|EPSD\|PSP\|Sugiyama	KHSRP FUBP2	DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93100	S27	Sugiyama	PHKB	LTAEVSWKVLERRARTKRsGsVyEPLKsINLPRPDNETLWD
Q96B36	T246	SIGNOR\|ELM\|EPSD	AKT1S1 PRAS40	VLREAEDtQVFGDLPRPRLNtsDFQKLKRKY__________
Q96F86	S161	SIGNOR\|EPSD\|PSP	EDC3 LSM16 YJDC YJEFN2 PP844	YVDRHMEsLsQsKSFRRRHNsWssSSRHPNQAtPKKSGLKN
Q96FS4	S55	Sugiyama	SIPA1 SPA1	PLTPHTFEPRPVRGPLLRsGsDAGEARPPtPAsPRARAHsH
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96HP0	S1194	SIGNOR	DOCK6 KIAA1395	DTLPRLHDFAEGPGQRSRLAsMLDsDtEGEGDIAGTINPSV
Q96MH2	T196	Sugiyama	HEXIM2 L3	GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96QB1	S766	SIGNOR	DLC1 ARHGAP7 KIAA1723 STARD12	QSETSSAVSTPSPVTRTRsLsACNKRVGMYLEGFDPFNQST
Q96S44	S250	SIGNOR	TP53RK C20orf64 PRPK	KKARPVLKKLDEVRLRGRKRsMVG_________________
Q99490	S985	SIGNOR	AGAP2 CENTG1 KIAA0167	ICIECSGIHRNLGTHLSRVRsLDLDDWPRELTLVLTAIGND
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99623	S176	PSP	PHB2 BAP REA	QRAQVsLLIRRELTERAKDFsLILDDVAITELSFSREYTAA
Q99623	S91	PSP	PHB2 BAP REA	RIPWFQYPIIYDIRARPRKIssPTGSKDLQMVNISLRVLSR
Q99683	S83	SIGNOR\|ELM\|EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	PGIGCPAATSSSSATRGRGSsVGGGSRRTTVAYVINEASQG
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BRS8	S451	SIGNOR	LARP6	PWVRRRRQAEMGtQEKsPGtsPLLSRKMQTADGLPVGVLRL
Q9BVI0	S291	SIGNOR	PHF20 C20orf104 GLEA2 HCA58 NZF TZP	VDSNSQTLQPITLELRRRKIsKGCEVPLKRPRLDKNSSQEK
Q9BW19	T159	Sugiyama	KIFC1 HSET KNSL2	LKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQVK
Q9BWT1	T163	SIGNOR	CDCA7 JPO1	FRGRHPLPGSDSQSRRPRRRtFPGVASRRNPERRARPLTRS
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYW2	S2080	Sugiyama	SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069	SRERDPDKQTQNKEKRKRRssLsPPssAYERGTKRPDDRYD
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6	S197	Sugiyama	PRKD2 PKD2 HSPC187	HKRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPC
Q9BZL6	T199	Sugiyama	PRKD2 PKD2 HSPC187	RCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTA
Q9BZQ8	S602	SIGNOR	NIBAN1 C1orf24 FAM129A NIBAN GIG39	sLtDLKPPtGsNQAsPARRAsAILPGVLGsEtLsNEVFQEs
Q9GZV1	S99	SIGNOR\|EPSD\|PSP	ANKRD2 ARPP	HGAQsAALQKVKGQERVRKTsLDLRREIIDVGGIQNLIELR
Q9H0B6	S428	Sugiyama	KLC2	NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H0H5	T249	EPSD\|PSP	RACGAP1 KIAA1478 MGCRACGAP	PIEAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPR
Q9H3H1	S431	Sugiyama	TRIT1 IPT MOD5	AAHIKSKSHLNQLKKRRRLDsDAVNTIEsQsVsPDHNKEPK
Q9H3Q1	S309	Sugiyama	CDC42EP4 BORG4 CEP4	AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD
Q9H4A3	T60	SIGNOR\|ELM	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GAAAADAVtGRtEEyRRRRHtMDKDSRGAAAtTtTTEHRFF
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H6Z4	S126	SIGNOR	RANBP3	EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP
Q9H6Z4	S57	SIGNOR	RANBP3	SGEEPRGEAEAPHHGTGHPEsAGEHALEPPAPAGASASTPP
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788	S316	Sugiyama	SH2D4A PPP1R38 SH2A	NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HBH7	S102	SIGNOR	BEX1	MERIGEEVRQLMEKLREKQLsHSLRAVSTDPPHHDHHDEFC
Q9NP61	S367	Sugiyama	ARFGAP3 ARFGAP1	DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NPC1	T324	SIGNOR	LTB4R2 BLT2R BLTR2	LTRLFEGSGEARGGGRSREGtMELRTTPQLKVVGQGRGNGD
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NVN8	S513	Sugiyama	GNL3L	PNRHQMGWAKRNVDHRPKsNsMVDVCsVDRRSVLQRIMETD
Q9NWS0	S173	Sugiyama	PIH1D1 NOP17	KYNLQLNPEWRMMKNRPFMGsIsQQNIRSEQRPRIQELGDL
Q9NZN5	S1288	Sugiyama	ARHGEF12 KIAA0382 LARG	GLTEKsVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHs
Q9P0N9	S124	SIGNOR	TBC1D7 TBC7 HSPC239	QAEVYLRMYQLESGKLPRSPsFPLEPDDEVFLAIAKAMEEM
Q9UBK2	S571	SIGNOR	PPARGC1A LEM6 PGC1 PGC1A PPARGC1	VSPPKSLFSQRPQRMRSRSRsFSRHRSCSRSPYSRSRSRSP
Q9UBP6	S27	SIGNOR\|Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2	S333	Sugiyama	NDRG3	MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UH77	S433	SIGNOR	KLHL3 KIAA1129	AYSYKTNEWFFVAPMNTRRSsVGVGVVEGKLYAVGGYDGAS
Q9UKJ3	S890	Sugiyama	GPATCH8 GPATC8 KIAA0553	YSSSSDASSDQSCYSRQRSYsDDSYSDYSDRSRRHSKRSHD
Q9UKV8	S387	Sugiyama	AGO2 EIF2C2	ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2	S199	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	GKsQsFHtAGSLPPTGRRsGstsSLSySTWTSSHSDKTHAR
Q9ULL1	S611	Sugiyama	PLEKHG1 KIAA1209	GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35	S974	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPCsNVEsRLLPRYsHsGsssPDtKVKPEtPPRQsHsGsIs
Q9UQ35	T977	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sNVEsRLLPRYsHsGsssPDtKVKPEtPPRQsHsGsIsPyP
Q9UQC2	S159	SIGNOR\|ELM	GAB2 KIAA0571	RssPAELssssQHLLRERKSsAPSHSSQPTLFTFEPPVSNH
Q9Y243	T309	Sugiyama	AKT3 PKBG	DFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGRAVDW
Q9Y261	T156	SIGNOR	FOXA2 HNF3B TCF3B	MYGQAGLSRARDPKTYRRSYtHAKPPYSYISLITMAIQQSP
Q9Y2B0	S55	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2I7	S307	SIGNOR\|ELM	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2I7	S318	EPSD	PIKFYVE KIAA0981 PIP5K3	KsPARNRsAsItNLsLDRsGsPMVPSYEtsVsPQANRTYVR
Q9Y2T7	S137	SIGNOR	YBX2 CSDA3 MSY2	EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2V2	S52	SIGNOR\|Sugiyama	CARHSP1	sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3C5	T135	SIGNOR	RNF11 CGI-123	LPCMHIYHLDCIDDWLMRSFtCPSCMEPVDAALLSSYETN_
Q9Y3M2	S20	EPSD\|PSP	CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025	_MPFFGNTFsPKKTPPRKsAsLsNLHsLDRSTREVELGLEY
Q9Y4H2	S1149	PSP	IRS2	PHRGAKVIRADPQGGRRRHssEtFsstttVtPVsPsFAHNP
Q9Y4H2	S306	PSP	IRS2	TILEAMKALKELFEFRPRsKsQssGssATHPISVPGARRHH
Q9Y4H2	S365	PSP	IRS2	DsLAAtPPAAKCSSCRVRtAsEGDGGAAAGAAAAGARPVsV
Q9Y4H2	S577	PSP	IRS2	RRVsGDAAQDLDRGLRKRtYsLtTPARQRPVPQPssAsLDE
Q9Y4I1	T1650	SIGNOR	MYO5A MYH12	LEHETIQGVSGVKPTGLRKRtssIADEGtYTLDSILRQLNS
Q9Y4P1	S34	SIGNOR	ATG4B APG4B AUTL1 KIAA0943	AEFEDFPETSEPVWILGRKYsIFtEKDEILSDVASRLWFTY
Q9Y580	S136	Sugiyama	RBM7	RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y6D5	S277	Sugiyama	ARFGEF2 ARFGEP2 BIG2	RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.592056e-09	8.586	1	1
Chromatin organization	R-HSA-4839726	1.154912e-08	7.937	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.103526e-08	7.957	0	0
Cell Cycle	R-HSA-1640170	4.645950e-08	7.333	1	0
Signal Transduction	R-HSA-162582	2.571574e-07	6.590	1	0
Apoptotic execution phase	R-HSA-75153	4.510148e-07	6.346	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.243858e-07	6.034	0	0
RNA Polymerase II Transcription	R-HSA-73857	8.807967e-07	6.055	1	0
NRAGE signals death through JNK	R-HSA-193648	9.256466e-07	6.034	0	0
Cellular Senescence	R-HSA-2559583	8.551710e-07	6.068	0	0
Gene expression (Transcription)	R-HSA-74160	2.302823e-06	5.638	1	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.788401e-06	5.555	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.169511e-06	5.499	0	0
Cell Cycle, Mitotic	R-HSA-69278	3.670229e-06	5.435	1	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.696719e-06	5.328	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.277890e-06	5.138	0	0
PKMTs methylate histone lysines	R-HSA-3214841	8.365807e-06	5.077	0	0
Generic Transcription Pathway	R-HSA-212436	8.794065e-06	5.056	1	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.010998e-05	4.995	0	0
G alpha (12/13) signalling events	R-HSA-416482	9.839365e-06	5.007	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.155560e-05	4.937	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.320300e-05	4.879	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.300313e-05	4.886	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.392936e-05	4.856	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.522975e-05	4.817	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.777901e-05	4.750	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.784656e-05	4.555	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.739203e-05	4.562	0	0
Meiotic synapsis	R-HSA-1221632	3.221838e-05	4.492	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.141541e-05	4.503	1	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.408502e-05	4.356	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	4.521147e-05	4.345	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.743706e-05	4.241	1	0
G2/M DNA damage checkpoint	R-HSA-69473	6.888118e-05	4.162	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	7.840352e-05	4.106	0	0
ESR-mediated signaling	R-HSA-8939211	9.153549e-05	4.038	1	0
Meiosis	R-HSA-1500620	9.596332e-05	4.018	0	0
Death Receptor Signaling	R-HSA-73887	9.252542e-05	4.034	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.039818e-04	3.983	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.114766e-04	3.953	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.312022e-04	3.882	0	0
Axon guidance	R-HSA-422475	1.339912e-04	3.873	0	0
HATs acetylate histones	R-HSA-3214847	1.500129e-04	3.824	0	0
DNA methylation	R-HSA-5334118	1.909791e-04	3.719	0	0
PRC2 methylates histones and DNA	R-HSA-212300	1.897576e-04	3.722	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.829995e-04	3.738	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.928565e-04	3.715	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.942328e-04	3.712	1	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.097223e-04	3.678	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.343013e-04	3.630	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.563689e-04	3.591	0	0
Mitotic Prophase	R-HSA-68875	2.718210e-04	3.566	0	0
Nervous system development	R-HSA-9675108	3.053872e-04	3.515	0	0
Packaging Of Telomere Ends	R-HSA-171306	3.395688e-04	3.469	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.384856e-04	3.470	0	0
Reproduction	R-HSA-1474165	3.410705e-04	3.467	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	3.395688e-04	3.469	0	0
HDACs deacetylate histones	R-HSA-3214815	3.554658e-04	3.449	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.657942e-04	3.437	0	0
Signaling by Hippo	R-HSA-2028269	3.771753e-04	3.423	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.127574e-04	3.384	1	0
PIP3 activates AKT signaling	R-HSA-1257604	5.145470e-04	3.289	1	1
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.511528e-04	3.259	1	1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.472640e-04	3.262	1	0
Processing of DNA double-strand break ends	R-HSA-5693607	5.567807e-04	3.254	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.460463e-04	3.190	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.529583e-04	3.185	0	0
Rap1 signalling	R-HSA-392517	7.643851e-04	3.117	0	0
Homology Directed Repair	R-HSA-5693538	8.041223e-04	3.095	0	0
M Phase	R-HSA-68886	8.301600e-04	3.081	0	0
Diseases of programmed cell death	R-HSA-9645723	8.927726e-04	3.049	0	0
Meiotic recombination	R-HSA-912446	9.815138e-04	3.008	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	9.223170e-04	3.035	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.508654e-04	3.022	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	9.857969e-04	3.006	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.096319e-03	2.960	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.101133e-03	2.958	1	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.169304e-03	2.932	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.294897e-03	2.888	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.366723e-03	2.864	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.404329e-03	2.853	1	0
G2/M Checkpoints	R-HSA-69481	1.415769e-03	2.849	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.478985e-03	2.830	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.478985e-03	2.830	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.640748e-03	2.785	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.684314e-03	2.774	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.773225e-03	2.751	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.783779e-03	2.749	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.805740e-03	2.743	1	1
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.852276e-03	2.732	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.067236e-03	2.685	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.067236e-03	2.685	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.067236e-03	2.685	0	0
Signaling by VEGF	R-HSA-194138	2.067236e-03	2.685	1	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.099523e-03	2.678	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.376768e-03	2.624	1	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.511517e-03	2.600	0	0
Regulation of TP53 Expression	R-HSA-6804754	2.681051e-03	2.572	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.806004e-03	2.552	0	0
Defective pyroptosis	R-HSA-9710421	3.029217e-03	2.519	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.272287e-03	2.485	0	0
MECP2 regulates transcription factors	R-HSA-9022707	3.282784e-03	2.484	0	0
Post NMDA receptor activation events	R-HSA-438064	3.186391e-03	2.497	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	3.454670e-03	2.462	1	0
RET signaling	R-HSA-8853659	3.879468e-03	2.411	0	0
Oncogenic MAPK signaling	R-HSA-6802957	4.233121e-03	2.373	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.344848e-03	2.362	0	0
Nucleosome assembly	R-HSA-774815	4.344848e-03	2.362	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.553278e-03	2.342	0	0
Specification of primordial germ cells	R-HSA-9827857	4.637668e-03	2.334	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	4.717612e-03	2.326	0	0
Cleavage of the damaged purine	R-HSA-110331	4.717612e-03	2.326	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.174061e-03	2.286	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	5.174061e-03	2.286	0	0
HDMs demethylate histones	R-HSA-3214842	5.335648e-03	2.273	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.618533e-03	2.250	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	5.925644e-03	2.227	0	0
Depurination	R-HSA-73927	5.696313e-03	2.244	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	5.943003e-03	2.226	0	0
Depyrimidination	R-HSA-73928	5.943003e-03	2.226	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	5.949935e-03	2.225	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.982279e-03	2.223	0	0
Activation of RAC1	R-HSA-428540	6.021802e-03	2.220	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.125140e-03	2.213	0	0
mRNA 3'-end processing	R-HSA-72187	6.166792e-03	2.210	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	6.762117e-03	2.170	0	0
Regulation of endogenous retroelements	R-HSA-9842860	6.803214e-03	2.167	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.761773e-03	2.110	0	0
Assembly of the pre-replicative complex	R-HSA-68867	7.452055e-03	2.128	0	0
Germ layer formation at gastrulation	R-HSA-9754189	7.955051e-03	2.099	0	0
Protein-protein interactions at synapses	R-HSA-6794362	8.103290e-03	2.091	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.288372e-03	2.082	0	0
CREB phosphorylation	R-HSA-199920	9.623793e-03	2.017	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.017388e-02	1.993	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.022562e-02	1.990	0	0
Regulation of TP53 Degradation	R-HSA-6804757	9.384935e-03	2.028	1	1
Calmodulin induced events	R-HSA-111933	9.384935e-03	2.028	0	0
DAG and IP3 signaling	R-HSA-1489509	9.749732e-03	2.011	0	0
CaM pathway	R-HSA-111997	9.384935e-03	2.028	0	0
Cell junction organization	R-HSA-446728	1.028956e-02	1.988	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.079275e-02	1.967	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.085822e-02	1.964	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.089892e-02	1.963	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.089892e-02	1.963	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.089892e-02	1.963	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.093977e-02	1.961	0	0
Ion homeostasis	R-HSA-5578775	1.110637e-02	1.954	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.115683e-02	1.952	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.115683e-02	1.952	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.117121e-02	1.952	0	0
DARPP-32 events	R-HSA-180024	1.236866e-02	1.908	0	0
Chromosome Maintenance	R-HSA-73886	1.163396e-02	1.934	0	0
Telomere Maintenance	R-HSA-157579	1.275478e-02	1.894	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.273302e-02	1.895	0	0
Signaling by ROBO receptors	R-HSA-376176	1.164674e-02	1.934	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.301514e-02	1.886	0	0
mRNA Splicing	R-HSA-72172	1.338928e-02	1.873	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.410438e-02	1.851	0	0
Regulation of PTEN localization	R-HSA-8948747	1.455652e-02	1.837	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.525666e-02	1.817	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.552199e-02	1.809	1	1
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.810991e-02	1.742	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.810991e-02	1.742	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.810991e-02	1.742	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.810991e-02	1.742	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.661029e-02	1.780	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.661029e-02	1.780	0	0
Netrin-1 signaling	R-HSA-373752	1.791265e-02	1.747	0	0
TRP channels	R-HSA-3295583	1.715104e-02	1.766	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.717211e-02	1.765	0	0
Apoptosis	R-HSA-109581	1.701129e-02	1.769	1	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.635406e-02	1.786	0	0
NrCAM interactions	R-HSA-447038	1.810991e-02	1.742	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.723735e-02	1.764	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.744799e-02	1.758	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.844053e-02	1.734	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.963560e-02	1.707	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.964620e-02	1.707	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.964620e-02	1.707	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.988764e-02	1.701	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.026257e-02	1.693	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.073378e-02	1.683	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	2.114279e-02	1.675	0	0
Cell-Cell communication	R-HSA-1500931	2.199031e-02	1.658	0	0
Signaling by NTRKs	R-HSA-166520	2.234394e-02	1.651	0	0
Deubiquitination	R-HSA-5688426	2.299222e-02	1.638	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.311089e-02	1.636	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.387136e-02	1.622	1	1
Cardiogenesis	R-HSA-9733709	2.489423e-02	1.604	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.502170e-02	1.602	0	0
Neurexins and neuroligins	R-HSA-6794361	2.601920e-02	1.585	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.384453e-02	1.623	0	0
Ub-specific processing proteases	R-HSA-5689880	2.610704e-02	1.583	0	0
FOXO-mediated transcription	R-HSA-9614085	2.647917e-02	1.577	1	0
Semaphorin interactions	R-HSA-373755	2.675199e-02	1.573	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.745393e-02	1.561	0	0
Signaling by LTK	R-HSA-9842663	2.747324e-02	1.561	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.772661e-02	1.557	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.772661e-02	1.557	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.772661e-02	1.557	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.772661e-02	1.557	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.772661e-02	1.557	0	0
MTOR signalling	R-HSA-165159	2.791869e-02	1.554	1	0
Ca-dependent events	R-HSA-111996	2.791869e-02	1.554	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.804375e-02	1.552	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.872417e-02	1.542	0	0
Mitotic Prometaphase	R-HSA-68877	2.949960e-02	1.530	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.294503e-02	1.482	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.294503e-02	1.482	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	3.294503e-02	1.482	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.294503e-02	1.482	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.294503e-02	1.482	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	3.525032e-02	1.453	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.337639e-02	1.477	0	0
RAF activation	R-HSA-5673000	3.380613e-02	1.471	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.297593e-02	1.482	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	3.151126e-02	1.502	0	0
S Phase	R-HSA-69242	3.419053e-02	1.466	1	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.525032e-02	1.453	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.314540e-02	1.480	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.525293e-02	1.453	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.862390e-02	1.413	0	0
PLC beta mediated events	R-HSA-112043	3.929286e-02	1.406	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.988347e-02	1.399	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.011170e-02	1.397	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.018975e-02	1.396	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	4.054719e-02	1.392	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.106771e-02	1.386	0	0
Signaling by WNT	R-HSA-195721	4.248666e-02	1.372	1	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.258878e-02	1.371	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.284551e-02	1.368	1	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.301183e-02	1.366	1	1
Programmed Cell Death	R-HSA-5357801	4.425401e-02	1.354	1	0
Muscle contraction	R-HSA-397014	4.626215e-02	1.335	0	0
HCN channels	R-HSA-1296061	5.408551e-02	1.267	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	5.462461e-02	1.263	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.462461e-02	1.263	0	0
PKA activation	R-HSA-163615	4.693130e-02	1.329	0	0
PKA activation in glucagon signalling	R-HSA-164378	4.693130e-02	1.329	0	0
Integrin signaling	R-HSA-354192	5.319007e-02	1.274	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.106162e-02	1.292	1	1
Formation of RNA Pol II elongation complex	R-HSA-112382	4.915852e-02	1.308	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.835305e-02	1.316	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.835305e-02	1.316	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.001427e-02	1.301	0	0
Centrosome maturation	R-HSA-380287	5.138261e-02	1.289	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.693130e-02	1.329	0	0
Polo-like kinase mediated events	R-HSA-156711	4.693130e-02	1.329	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	5.319007e-02	1.274	0	0
Dopamine receptors	R-HSA-390651	5.408551e-02	1.267	0	0
Cardiac conduction	R-HSA-5576891	4.821071e-02	1.317	0	0
DNA Repair	R-HSA-73894	5.228393e-02	1.282	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.732697e-02	1.325	0	0
Cell-cell junction organization	R-HSA-421270	5.004881e-02	1.301	0	0
DCC mediated attractive signaling	R-HSA-418885	5.471655e-02	1.262	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	5.471655e-02	1.262	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.471655e-02	1.262	0	0
p75NTR signals via NF-kB	R-HSA-193639	5.471655e-02	1.262	0	0
Cell-extracellular matrix interactions	R-HSA-446353	5.471655e-02	1.262	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.476522e-02	1.261	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.622855e-02	1.250	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.631122e-02	1.249	0	0
Specification of the neural plate border	R-HSA-9834899	5.631122e-02	1.249	0	0
G2/M Transition	R-HSA-69275	5.773312e-02	1.239	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.793109e-02	1.237	0	0
Co-stimulation by CD28	R-HSA-389356	5.819674e-02	1.235	1	0
Cellular responses to mechanical stimuli	R-HSA-9855142	5.953558e-02	1.225	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	6.767800e-02	1.170	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.330028e-02	1.199	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	6.330028e-02	1.199	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.647116e-02	1.177	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.677510e-02	1.175	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.677510e-02	1.175	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.677510e-02	1.175	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.677510e-02	1.175	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.677510e-02	1.175	0	0
Formation of definitive endoderm	R-HSA-9823730	6.677510e-02	1.175	0	0
EPHB-mediated forward signaling	R-HSA-3928662	6.903589e-02	1.161	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.330028e-02	1.199	0	0
RNA Polymerase I Transcription	R-HSA-73864	6.685565e-02	1.175	0	0
Opioid Signalling	R-HSA-111885	6.388046e-02	1.195	0	0
Adrenoceptors	R-HSA-390696	7.191344e-02	1.143	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.338089e-02	1.198	0	0
G-protein mediated events	R-HSA-112040	7.067600e-02	1.151	0	0
Mitotic G2-G2/M phases	R-HSA-453274	6.438175e-02	1.191	0	0
Neurodegenerative Diseases	R-HSA-8863678	6.551292e-02	1.184	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.551292e-02	1.184	0	0
Adherens junctions interactions	R-HSA-418990	6.331138e-02	1.199	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.191344e-02	1.143	0	0
TBC/RABGAPs	R-HSA-8854214	6.175069e-02	1.209	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.538503e-02	1.185	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	7.191344e-02	1.143	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.256061e-02	1.139	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.256061e-02	1.139	0	0
Interleukin-37 signaling	R-HSA-9008059	7.256061e-02	1.139	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	7.274243e-02	1.138	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.415468e-02	1.130	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.577906e-02	1.120	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.577906e-02	1.120	0	0
Long-term potentiation	R-HSA-9620244	7.577906e-02	1.120	0	0
Signaling by Interleukins	R-HSA-449147	7.637492e-02	1.117	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.685696e-02	1.114	1	1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	7.768682e-02	1.110	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	7.795918e-02	1.108	0	0
Signalling to ERKs	R-HSA-187687	7.795918e-02	1.108	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.812275e-02	1.107	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.830982e-02	1.106	0	0
p75NTR recruits signalling complexes	R-HSA-209543	7.830982e-02	1.106	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.830982e-02	1.106	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.830982e-02	1.106	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.830982e-02	1.106	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.830982e-02	1.106	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.830982e-02	1.106	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.877011e-02	1.104	0	0
FLT3 Signaling	R-HSA-9607240	8.208570e-02	1.086	1	1
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.521979e-02	1.069	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.521979e-02	1.069	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	8.521979e-02	1.069	0	0
Signaling by RAS mutants	R-HSA-6802949	8.521979e-02	1.069	0	0
Developmental Biology	R-HSA-1266738	8.688457e-02	1.061	1	0
G1/S-Specific Transcription	R-HSA-69205	8.757298e-02	1.058	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.049838e-01	0.979	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.049838e-01	0.979	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.049838e-01	0.979	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.049838e-01	0.979	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	1.049838e-01	0.979	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	9.164459e-02	1.038	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	9.164459e-02	1.038	0	0
Ephrin signaling	R-HSA-3928664	1.098014e-01	0.959	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.097893e-02	1.041	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.097893e-02	1.041	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.904511e-02	1.004	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	9.787042e-02	1.009	0	0
Signaling by RAF1 mutants	R-HSA-9656223	9.134369e-02	1.039	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.628347e-02	1.016	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	9.138684e-02	1.039	0	0
EPH-Ephrin signaling	R-HSA-2682334	9.176287e-02	1.037	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.098014e-01	0.959	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.232145e-02	1.035	1	1
GP1b-IX-V activation signalling	R-HSA-430116	9.164459e-02	1.038	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.904511e-02	1.004	1	1
Frs2-mediated activation	R-HSA-170968	9.505371e-02	1.022	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.070241e-01	0.971	1	1
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.095574e-01	0.960	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.326336e-02	1.030	0	0
Mitotic Anaphase	R-HSA-68882	1.048596e-01	0.979	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.403879e-02	1.027	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.047836e-01	0.980	0	0
DNA Replication	R-HSA-69306	9.776632e-02	1.010	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	9.134369e-02	1.039	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.047836e-01	0.980	1	1
Kinesins	R-HSA-983189	1.062451e-01	0.974	0	0
mTORC1-mediated signalling	R-HSA-166208	1.047007e-01	0.980	0	0
NGF-stimulated transcription	R-HSA-9031628	1.035806e-01	0.985	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.098014e-01	0.959	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.097893e-02	1.041	0	0
Stimuli-sensing channels	R-HSA-2672351	9.025912e-02	1.045	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.098014e-01	0.959	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.099769e-01	0.959	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.099769e-01	0.959	0	0
Potassium transport channels	R-HSA-1296067	1.099769e-01	0.959	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.103462e-01	0.957	0	0
Hedgehog 'off' state	R-HSA-5610787	1.115211e-01	0.953	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.134596e-01	0.945	0	0
cGMP effects	R-HSA-418457	1.134596e-01	0.945	0	0
HDL assembly	R-HSA-8963896	1.134596e-01	0.945	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.134596e-01	0.945	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.136568e-01	0.944	0	0
Signal attenuation	R-HSA-74749	1.136568e-01	0.944	0	0
Regulation of CDH11 function	R-HSA-9762292	1.136568e-01	0.944	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.136568e-01	0.944	0	0
MAP kinase activation	R-HSA-450294	1.153977e-01	0.938	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.154512e-01	0.938	1	1
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.170714e-01	0.932	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.170714e-01	0.932	0	0
Neuronal System	R-HSA-112316	1.206538e-01	0.918	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.213963e-01	0.916	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.216938e-01	0.915	1	0
RMTs methylate histone arginines	R-HSA-3214858	1.227425e-01	0.911	0	0
Cellular responses to stimuli	R-HSA-8953897	1.244161e-01	0.905	1	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.246667e-01	0.904	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.246667e-01	0.904	0	0
Gene Silencing by RNA	R-HSA-211000	1.246667e-01	0.904	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.258858e-01	0.900	0	0
PI Metabolism	R-HSA-1483255	1.263580e-01	0.898	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.268211e-01	0.897	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.313784e-01	0.881	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.313784e-01	0.881	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.313784e-01	0.881	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.313784e-01	0.881	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.572560e-01	0.803	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.572560e-01	0.803	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.354438e-01	0.868	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.354438e-01	0.868	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.684994e-01	0.773	0	0
Ca2+ activated K+ channels	R-HSA-1296052	1.684994e-01	0.773	0	0
SOS-mediated signalling	R-HSA-112412	1.684994e-01	0.773	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.684994e-01	0.773	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.684994e-01	0.773	0	0
Signaling by APC mutants	R-HSA-4839744	1.377457e-01	0.861	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.377457e-01	0.861	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.377457e-01	0.861	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.377457e-01	0.861	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.548448e-01	0.810	0	0
Differentiation of T cells	R-HSA-9945266	1.548448e-01	0.810	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.519990e-01	0.818	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.301107e-01	0.886	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.301107e-01	0.886	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.328043e-01	0.877	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.593252e-01	0.798	0	0
snRNP Assembly	R-HSA-191859	1.578096e-01	0.802	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.578096e-01	0.802	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.681313e-01	0.774	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.343951e-01	0.872	0	0
Signaling by ERBB2	R-HSA-1227986	1.697255e-01	0.770	1	0
ERK/MAPK targets	R-HSA-198753	1.643564e-01	0.784	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.636760e-01	0.786	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.301107e-01	0.886	0	0
NF-kB is activated and signals survival	R-HSA-209560	1.636760e-01	0.786	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.659924e-01	0.780	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.445584e-01	0.840	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.445584e-01	0.840	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.445584e-01	0.840	0	0
Prolonged ERK activation events	R-HSA-169893	1.548448e-01	0.810	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.481439e-01	0.829	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.481439e-01	0.829	0	0
Protein ubiquitination	R-HSA-8852135	1.334558e-01	0.875	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.636760e-01	0.786	0	0
Rab regulation of trafficking	R-HSA-9007101	1.704732e-01	0.768	1	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.353403e-01	0.869	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.343951e-01	0.872	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.636760e-01	0.786	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.636760e-01	0.786	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.548448e-01	0.810	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.467546e-01	0.833	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.547941e-01	0.810	0	0
L1CAM interactions	R-HSA-373760	1.619346e-01	0.791	0	0
Formation of the nephric duct	R-HSA-9830364	1.519990e-01	0.818	0	0
Glycolysis	R-HSA-70171	1.622849e-01	0.790	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.582840e-01	0.801	1	0
Base Excision Repair	R-HSA-73884	1.681313e-01	0.774	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	1.715705e-01	0.766	1	0
G0 and Early G1	R-HSA-1538133	1.723983e-01	0.763	0	0
GPER1 signaling	R-HSA-9634597	1.727250e-01	0.763	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.734929e-01	0.761	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.769701e-01	0.752	1	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.794826e-01	0.746	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.799613e-01	0.745	1	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.842358e-01	0.735	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.847044e-01	0.734	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.848224e-01	0.733	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.881567e-01	0.725	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.881567e-01	0.725	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.881567e-01	0.725	0	0
Signaling by ERBB4	R-HSA-1236394	1.882825e-01	0.725	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.892784e-01	0.723	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.894125e-01	0.723	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.894125e-01	0.723	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.455031e-01	0.610	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.455031e-01	0.610	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.455031e-01	0.610	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.455031e-01	0.610	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.455031e-01	0.610	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.455031e-01	0.610	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.455031e-01	0.610	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.074779e-01	0.683	0	0
NADE modulates death signalling	R-HSA-205025	2.074779e-01	0.683	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.074779e-01	0.683	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.074779e-01	0.683	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.074779e-01	0.683	1	1
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.074779e-01	0.683	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.074779e-01	0.683	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.074779e-01	0.683	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.446392e-01	0.463	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.446392e-01	0.463	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.446392e-01	0.463	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	3.446392e-01	0.463	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.446392e-01	0.463	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.446392e-01	0.463	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.446392e-01	0.463	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.446392e-01	0.463	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.446392e-01	0.463	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.446392e-01	0.463	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.446392e-01	0.463	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.446392e-01	0.463	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.446392e-01	0.463	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.446392e-01	0.463	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.446392e-01	0.463	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.446392e-01	0.463	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.446392e-01	0.463	0	0
Intestinal infectious diseases	R-HSA-8942233	3.446392e-01	0.463	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.446392e-01	0.463	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.446392e-01	0.463	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.590543e-01	0.587	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.590543e-01	0.587	0	0
IRS activation	R-HSA-74713	2.590543e-01	0.587	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.590543e-01	0.587	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.035811e-01	0.691	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.035811e-01	0.691	0	0
RSK activation	R-HSA-444257	2.035811e-01	0.691	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	2.035811e-01	0.691	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.035811e-01	0.691	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.035811e-01	0.691	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	1.911919e-01	0.719	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.911919e-01	0.719	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	1.911919e-01	0.719	0	0
Leading Strand Synthesis	R-HSA-69109	1.911919e-01	0.719	0	0
Polymerase switching	R-HSA-69091	1.911919e-01	0.719	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	2.401405e-01	0.620	0	0
Lipophagy	R-HSA-9613354	2.401405e-01	0.620	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.401405e-01	0.620	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.107628e-01	0.508	0	0
Phosphorylation of Emi1	R-HSA-176417	3.107628e-01	0.508	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.107628e-01	0.508	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.107628e-01	0.508	0	0
Signaling by MAPK mutants	R-HSA-9652817	3.107628e-01	0.508	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.307544e-01	0.366	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.307544e-01	0.366	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.307544e-01	0.366	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.307544e-01	0.366	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.307544e-01	0.366	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.307544e-01	0.366	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.307544e-01	0.366	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.307544e-01	0.366	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.307544e-01	0.366	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.307544e-01	0.366	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.307544e-01	0.366	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.200274e-01	0.658	1	1
Formation of axial mesoderm	R-HSA-9796292	2.200274e-01	0.658	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.200274e-01	0.658	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.200274e-01	0.658	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.776655e-01	0.556	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.776655e-01	0.556	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.499138e-01	0.602	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.616791e-01	0.442	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.059783e-01	0.686	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.156896e-01	0.501	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.156896e-01	0.501	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.156896e-01	0.501	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	3.156896e-01	0.501	0	0
Erythropoietin activates RAS	R-HSA-9027284	2.805869e-01	0.552	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.805869e-01	0.552	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.805869e-01	0.552	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.520672e-01	0.598	0	0
Interleukin receptor SHC signaling	R-HSA-912526	2.280733e-01	0.642	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.074356e-01	0.683	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.074356e-01	0.683	0	0
Deadenylation of mRNA	R-HSA-429947	2.508802e-01	0.601	0	0
Co-inhibition by CTLA4	R-HSA-389513	2.784712e-01	0.555	1	1
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.117919e-01	0.506	0	0
Phosphorylation of the APC/C	R-HSA-176412	3.117919e-01	0.506	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	3.537974e-01	0.451	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.537974e-01	0.451	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.111189e-01	0.386	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.111189e-01	0.386	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.111189e-01	0.386	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.111189e-01	0.386	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.111189e-01	0.386	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	4.111189e-01	0.386	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.111189e-01	0.386	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.111189e-01	0.386	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.055583e-01	0.296	0	0
Axonal growth stimulation	R-HSA-209563	5.055583e-01	0.296	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.055583e-01	0.296	0	0
Invadopodia formation	R-HSA-8941237	5.055583e-01	0.296	0	0
Defective ABCA1 causes TGD	R-HSA-5682113	5.055583e-01	0.296	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.055583e-01	0.296	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	5.055583e-01	0.296	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.055583e-01	0.296	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.056559e-01	0.687	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.056559e-01	0.687	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.480211e-01	0.606	0	0
Activation of the pre-replicative complex	R-HSA-68962	2.480211e-01	0.606	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.480211e-01	0.606	0	0
Tight junction interactions	R-HSA-420029	2.742866e-01	0.562	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.053891e-01	0.515	0	0
HIV Transcription Elongation	R-HSA-167169	2.225868e-01	0.653	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.225868e-01	0.653	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.225868e-01	0.653	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.432881e-01	0.464	0	0
Trafficking of AMPA receptors	R-HSA-399719	2.691673e-01	0.570	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.981795e-01	0.526	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.916261e-01	0.407	0	0
IRAK1 recruits IKK complex	R-HSA-937039	3.916261e-01	0.407	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.916261e-01	0.407	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	3.916261e-01	0.407	0	0
HSF1-dependent transactivation	R-HSA-3371571	2.156725e-01	0.666	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.907719e-01	0.536	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.224461e-01	0.492	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.224461e-01	0.492	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.748514e-01	0.426	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.748514e-01	0.426	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.585914e-01	0.339	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.585914e-01	0.339	0	0
Activation of RAS in B cells	R-HSA-1169092	4.585914e-01	0.339	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.465121e-01	0.608	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.127505e-01	0.505	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.469756e-01	0.460	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.469756e-01	0.460	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.288653e-01	0.368	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.288653e-01	0.368	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.149683e-01	0.668	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.350192e-01	0.475	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	2.377854e-01	0.624	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.062771e-01	0.391	0	0
Signaling by Erythropoietin	R-HSA-9006335	3.716603e-01	0.430	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.963969e-01	0.402	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	4.151295e-01	0.382	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	4.373802e-01	0.359	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.373802e-01	0.359	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.373802e-01	0.359	0	0
Removal of the Flap Intermediate	R-HSA-69166	4.652550e-01	0.332	0	0
WNT mediated activation of DVL	R-HSA-201688	5.037601e-01	0.298	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.037601e-01	0.298	0	0
MTF1 activates gene expression	R-HSA-5660489	5.705360e-01	0.244	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.705360e-01	0.244	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.705360e-01	0.244	1	1
ATP sensitive Potassium channels	R-HSA-1296025	5.705360e-01	0.244	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.705360e-01	0.244	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.705360e-01	0.244	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.705360e-01	0.244	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.865639e-01	0.413	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.210871e-01	0.376	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.210871e-01	0.376	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.639761e-01	0.439	0	0
Transcription of the HIV genome	R-HSA-167172	3.853723e-01	0.414	0	0
Spry regulation of FGF signaling	R-HSA-1295596	5.005822e-01	0.301	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.005822e-01	0.301	0	0
SHC1 events in EGFR signaling	R-HSA-180336	5.005822e-01	0.301	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.005822e-01	0.301	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.005822e-01	0.301	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.699647e-01	0.328	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	4.979842e-01	0.303	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	4.979842e-01	0.303	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.464107e-01	0.262	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.875821e-01	0.412	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.875821e-01	0.412	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.527077e-01	0.344	0	0
Striated Muscle Contraction	R-HSA-390522	4.939866e-01	0.306	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.346776e-01	0.272	0	0
Attenuation phase	R-HSA-3371568	4.923655e-01	0.308	0	0
Cellular response to heat stress	R-HSA-3371556	4.406593e-01	0.356	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.909113e-01	0.309	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.272194e-01	0.278	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.218295e-01	0.282	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.356921e-01	0.271	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.356921e-01	0.271	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.408355e-01	0.267	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.472331e-01	0.262	0	0
Late endosomal microautophagy	R-HSA-9615710	5.472331e-01	0.262	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	5.555995e-01	0.255	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.674106e-01	0.246	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.674106e-01	0.246	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.674106e-01	0.246	0	0
Phase 2 - plateau phase	R-HSA-5576893	5.674106e-01	0.246	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.674106e-01	0.246	0	0
HCMV Early Events	R-HSA-9609690	5.452318e-01	0.263	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.596161e-01	0.252	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	5.472331e-01	0.262	0	0
IGF1R signaling cascade	R-HSA-2428924	3.191138e-01	0.496	1	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.923655e-01	0.308	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.923655e-01	0.308	0	0
Signaling by FGFR4	R-HSA-5654743	4.285767e-01	0.368	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.554641e-01	0.255	0	0
Regulation of mitotic cell cycle	R-HSA-453276	5.554641e-01	0.255	0	0
Signaling by EGFR	R-HSA-177929	2.954363e-01	0.530	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.253665e-01	0.371	0	0
Adipogenesis	R-HSA-9843745	3.347454e-01	0.475	0	0
Lagging Strand Synthesis	R-HSA-69186	4.979842e-01	0.303	0	0
Telomere Extension By Telomerase	R-HSA-171319	5.218295e-01	0.282	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.263399e-01	0.645	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.432881e-01	0.464	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	5.472331e-01	0.262	0	0
Signaling by FGFR3	R-HSA-5654741	4.702965e-01	0.328	0	0
Generation of second messenger molecules	R-HSA-202433	3.447288e-01	0.463	0	0
DNA Damage Bypass	R-HSA-73893	5.512040e-01	0.259	0	0
p75NTR regulates axonogenesis	R-HSA-193697	5.037601e-01	0.298	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.386987e-01	0.269	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.059783e-01	0.686	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.442675e-01	0.612	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.264888e-01	0.645	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	4.652550e-01	0.332	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.005822e-01	0.301	0	0
Myogenesis	R-HSA-525793	4.693176e-01	0.329	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.169415e-01	0.664	1	1
G1/S DNA Damage Checkpoints	R-HSA-69615	3.029579e-01	0.519	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.354655e-01	0.474	1	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.401405e-01	0.620	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.776655e-01	0.556	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.263399e-01	0.645	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.585914e-01	0.339	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.151295e-01	0.382	0	0
Regulation of the apoptosome activity	R-HSA-9627069	5.464107e-01	0.262	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.190312e-01	0.378	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.423373e-01	0.466	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.432881e-01	0.464	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.113775e-01	0.386	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.113775e-01	0.386	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	2.401405e-01	0.620	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	3.107628e-01	0.508	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	2.776655e-01	0.556	0	0
LGI-ADAM interactions	R-HSA-5682910	3.156896e-01	0.501	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.111189e-01	0.386	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	2.254046e-01	0.647	0	0
DNA strand elongation	R-HSA-69190	4.456383e-01	0.351	0	0
Signalling to RAS	R-HSA-167044	4.979842e-01	0.303	0	0
Formation of apoptosome	R-HSA-111458	5.464107e-01	0.262	0	0
PI3K/AKT activation	R-HSA-198203	5.464107e-01	0.262	0	0
Switching of origins to a post-replicative state	R-HSA-69052	4.694777e-01	0.328	0	0
TNF signaling	R-HSA-75893	4.144362e-01	0.383	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.524820e-01	0.453	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.161411e-01	0.500	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.512040e-01	0.259	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.911919e-01	0.719	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	2.401405e-01	0.620	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.401405e-01	0.620	0	0
Regulation of gap junction activity	R-HSA-191650	5.705360e-01	0.244	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	5.005822e-01	0.301	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.452192e-01	0.610	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.406593e-01	0.356	0	0
TCR signaling	R-HSA-202403	4.536469e-01	0.343	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.981795e-01	0.526	0	0
Repression of WNT target genes	R-HSA-4641265	3.916261e-01	0.407	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.579218e-01	0.589	0	0
Recycling pathway of L1	R-HSA-437239	2.521913e-01	0.598	0	0
Apoptotic factor-mediated response	R-HSA-111471	4.062771e-01	0.391	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	3.716603e-01	0.430	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.293684e-01	0.482	0	0
DAP12 signaling	R-HSA-2424491	3.963969e-01	0.402	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.187399e-01	0.660	1	1
Potassium Channels	R-HSA-1296071	2.565691e-01	0.591	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.665023e-01	0.574	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.293684e-01	0.482	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.659547e-01	0.437	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.458509e-01	0.263	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.907719e-01	0.536	0	0
Signaling by Hedgehog	R-HSA-5358351	3.484547e-01	0.458	0	0
Integration of energy metabolism	R-HSA-163685	2.546760e-01	0.594	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.560211e-01	0.449	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.659547e-01	0.437	0	0
Gastrulation	R-HSA-9758941	4.881589e-01	0.311	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.401405e-01	0.620	0	0
Abacavir transmembrane transport	R-HSA-2161517	3.616791e-01	0.442	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.070999e-01	0.684	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	3.537974e-01	0.451	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	2.742866e-01	0.562	0	0
TGFBR3 PTM regulation	R-HSA-9839383	4.585914e-01	0.339	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.585914e-01	0.339	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.585914e-01	0.339	0	0
Nuclear RNA decay	R-HSA-9930044	3.127505e-01	0.505	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.127505e-01	0.505	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.350192e-01	0.475	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.037601e-01	0.298	0	0
Signaling by SCF-KIT	R-HSA-1433557	4.285767e-01	0.368	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	4.702965e-01	0.328	0	0
G1/S Transition	R-HSA-69206	1.931401e-01	0.714	1	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.406917e-01	0.468	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.702083e-01	0.328	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.550544e-01	0.593	0	0
Hedgehog 'on' state	R-HSA-5632684	4.358825e-01	0.361	0	0
Triglyceride catabolism	R-HSA-163560	5.635393e-01	0.249	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.350192e-01	0.475	0	0
Ovarian tumor domain proteases	R-HSA-5689896	4.253665e-01	0.371	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.199089e-01	0.495	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.432881e-01	0.464	0	0
Signaling by FGFR in disease	R-HSA-1226099	4.861640e-01	0.313	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.075784e-01	0.390	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.708820e-01	0.567	0	0
Regulation of KIT signaling	R-HSA-1433559	2.499138e-01	0.602	0	0
Platelet calcium homeostasis	R-HSA-418360	2.274166e-01	0.643	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.916261e-01	0.407	1	1
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.140587e-01	0.503	0	0
Interleukin-2 family signaling	R-HSA-451927	3.447288e-01	0.463	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.800965e-01	0.420	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.074779e-01	0.683	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.805869e-01	0.552	1	1
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.748514e-01	0.426	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.127505e-01	0.505	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.005822e-01	0.301	1	1
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	5.464107e-01	0.262	0	0
Interleukin-1 family signaling	R-HSA-446652	3.632488e-01	0.440	0	0
PTEN Regulation	R-HSA-6807070	2.854364e-01	0.544	1	0
Mismatch Repair	R-HSA-5358508	4.062771e-01	0.391	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.742866e-01	0.562	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.350192e-01	0.475	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.142001e-01	0.289	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.674106e-01	0.246	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.633338e-01	0.249	1	1
Adaptive Immune System	R-HSA-1280218	5.549917e-01	0.256	1	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.676410e-01	0.572	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.198604e-01	0.658	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	4.111189e-01	0.386	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.748514e-01	0.426	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.127505e-01	0.505	0	0
mRNA Editing	R-HSA-75072	5.037601e-01	0.298	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	5.158623e-01	0.287	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.169445e-01	0.380	0	0
Metabolism of RNA	R-HSA-8953854	4.967430e-01	0.304	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.423373e-01	0.466	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.674326e-01	0.246	0	0
G-protein beta:gamma signalling	R-HSA-397795	4.699647e-01	0.328	1	0
Interleukin-17 signaling	R-HSA-448424	2.169415e-01	0.664	0	0
MAPK family signaling cascades	R-HSA-5683057	2.046093e-01	0.689	0	0
Cellular responses to stress	R-HSA-2262752	2.153268e-01	0.667	1	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.455031e-01	0.610	0	0
Inhibition of PKR	R-HSA-169131	2.455031e-01	0.610	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.035811e-01	0.691	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.401405e-01	0.620	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	3.107628e-01	0.508	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	4.307544e-01	0.366	0	0
C6 deamination of adenosine	R-HSA-75102	4.307544e-01	0.366	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.307544e-01	0.366	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.263399e-01	0.645	0	0
Bicarbonate transporters	R-HSA-425381	3.156896e-01	0.501	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	3.156896e-01	0.501	0	0
The NLRP3 inflammasome	R-HSA-844456	2.520672e-01	0.598	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.274166e-01	0.643	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	3.117919e-01	0.506	0	0
MET interacts with TNS proteins	R-HSA-8875513	5.055583e-01	0.296	0	0
TGFBR3 expression	R-HSA-9839394	2.742866e-01	0.562	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.432881e-01	0.464	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.585914e-01	0.339	0	0
ISG15 antiviral mechanism	R-HSA-1169408	2.858558e-01	0.544	0	0
Unwinding of DNA	R-HSA-176974	5.037601e-01	0.298	0	0
Alanine metabolism	R-HSA-8964540	5.705360e-01	0.244	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.705360e-01	0.244	0	0
Metalloprotease DUBs	R-HSA-5689901	4.693176e-01	0.329	0	0
Cristae formation	R-HSA-8949613	4.958306e-01	0.305	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.939866e-01	0.306	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.674106e-01	0.246	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.144362e-01	0.383	1	0
Signaling by PTK6	R-HSA-8848021	5.423312e-01	0.266	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.423312e-01	0.266	0	0
Activation of BH3-only proteins	R-HSA-114452	3.963969e-01	0.402	1	0
Regulation of insulin secretion	R-HSA-422356	3.698067e-01	0.432	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.655933e-01	0.437	0	0
FLT3 signaling in disease	R-HSA-9682385	5.635393e-01	0.249	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.911919e-01	0.719	0	0
Amine ligand-binding receptors	R-HSA-375280	3.138538e-01	0.503	0	0
Downstream signal transduction	R-HSA-186763	4.210871e-01	0.376	0	0
Smooth Muscle Contraction	R-HSA-445355	4.895868e-01	0.310	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.401405e-01	0.620	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	5.464107e-01	0.262	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.674106e-01	0.246	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.326625e-01	0.478	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.127505e-01	0.505	0	0
Pyroptosis	R-HSA-5620971	5.218295e-01	0.282	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.590543e-01	0.587	0	0
Interleukin-1 processing	R-HSA-448706	2.401405e-01	0.620	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.107628e-01	0.508	0	0
CHL1 interactions	R-HSA-447041	4.111189e-01	0.386	0	0
Pervasive developmental disorders	R-HSA-9005895	3.916261e-01	0.407	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.916261e-01	0.407	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.916261e-01	0.407	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	3.748514e-01	0.426	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.601387e-01	0.444	0	0
Aquaporin-mediated transport	R-HSA-445717	2.713620e-01	0.566	0	0
Heme signaling	R-HSA-9707616	2.870301e-01	0.542	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.705360e-01	0.244	0	0
Protein hydroxylation	R-HSA-9629569	4.679969e-01	0.330	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.939866e-01	0.306	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.176320e-01	0.286	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	5.062316e-01	0.296	1	0
Co-inhibition by PD-1	R-HSA-389948	4.412537e-01	0.355	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.288653e-01	0.368	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	2.327720e-01	0.633	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.693176e-01	0.329	0	0
RUNX2 regulates bone development	R-HSA-8941326	5.635393e-01	0.249	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.151912e-01	0.501	0	0
Interleukin-15 signaling	R-HSA-8983432	3.916261e-01	0.407	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.515641e-01	0.345	0	0
Signaling by TGFBR3	R-HSA-9839373	3.524820e-01	0.453	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.345991e-01	0.362	0	0
Signaling by NOTCH	R-HSA-157118	3.083475e-01	0.511	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.224461e-01	0.492	0	0
Ion channel transport	R-HSA-983712	5.470145e-01	0.262	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.694389e-01	0.570	1	0
Breakdown of the nuclear lamina	R-HSA-352238	3.446392e-01	0.463	0	0
DSCAM interactions	R-HSA-376172	4.307544e-01	0.366	0	0
Maturation of nucleoprotein	R-HSA-9683610	2.200274e-01	0.658	0	0
Tandem pore domain potassium channels	R-HSA-1296346	2.776655e-01	0.556	0	0
Synthesis of PI	R-HSA-1483226	3.156896e-01	0.501	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.055583e-01	0.296	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	5.055583e-01	0.296	0	0
Alpha-defensins	R-HSA-1462054	4.585914e-01	0.339	0	0
Physiological factors	R-HSA-5578768	4.652550e-01	0.332	0	0
ARMS-mediated activation	R-HSA-170984	5.037601e-01	0.298	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.705360e-01	0.244	0	0
Sensory perception of sour taste	R-HSA-9729555	5.705360e-01	0.244	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.979842e-01	0.303	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.464107e-01	0.262	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.702419e-01	0.328	0	0
Regulation of gene expression in beta cells	R-HSA-210745	5.472331e-01	0.262	1	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.674106e-01	0.246	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.674106e-01	0.246	0	0
Diseases of DNA repair	R-HSA-9675135	2.355213e-01	0.628	0	0
Inflammasomes	R-HSA-622312	5.218295e-01	0.282	0	0
STING mediated induction of host immune responses	R-HSA-1834941	2.520672e-01	0.598	0	0
Plasma lipoprotein assembly	R-HSA-8963898	4.151295e-01	0.382	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.127505e-01	0.505	0	0
Signaling by ALK	R-HSA-201556	2.056559e-01	0.687	0	0
Glucose metabolism	R-HSA-70326	2.320418e-01	0.634	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	3.053891e-01	0.515	0	0
Histamine receptors	R-HSA-390650	5.055583e-01	0.296	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.037601e-01	0.298	0	0
Nuclear import of Rev protein	R-HSA-180746	5.176320e-01	0.286	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.005822e-01	0.301	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.005822e-01	0.301	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.307544e-01	0.366	0	0
NADPH regeneration	R-HSA-389542	3.616791e-01	0.442	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	4.111189e-01	0.386	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	5.055583e-01	0.296	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.055583e-01	0.296	0	0
Signaling by PDGFR in disease	R-HSA-9671555	3.326625e-01	0.478	0	0
Interleukin-18 signaling	R-HSA-9012546	4.585914e-01	0.339	0	0
Sodium/Proton exchangers	R-HSA-425986	4.585914e-01	0.339	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.705360e-01	0.244	0	0
Passive transport by Aquaporins	R-HSA-432047	5.674106e-01	0.246	0	0
Amyloid fiber formation	R-HSA-977225	1.962625e-01	0.707	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.007327e-01	0.397	0	0
Interleukin-7 signaling	R-HSA-1266695	2.742866e-01	0.562	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.693176e-01	0.329	0	0
Maturation of nucleoprotein	R-HSA-9694631	4.373802e-01	0.359	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.805869e-01	0.552	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.354622e-01	0.628	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	4.062771e-01	0.391	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.705053e-01	0.568	0	0
SARS-CoV-1 Infection	R-HSA-9678108	4.739592e-01	0.324	0	0
IRE1alpha activates chaperones	R-HSA-381070	3.528355e-01	0.452	0	0
Interleukin-12 signaling	R-HSA-9020591	4.046450e-01	0.393	0	0
Signaling by Leptin	R-HSA-2586552	5.464107e-01	0.262	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.719716e-01	0.243	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	5.719716e-01	0.243	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.719716e-01	0.243	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	5.719716e-01	0.243	1	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.719716e-01	0.243	0	0
Mitochondrial biogenesis	R-HSA-1592230	5.734584e-01	0.241	0	0
Nucleotide Excision Repair	R-HSA-5696398	5.804580e-01	0.236	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.830401e-01	0.234	1	1
Syndecan interactions	R-HSA-3000170	5.830401e-01	0.234	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.850969e-01	0.233	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.856924e-01	0.232	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.864252e-01	0.232	0	0
Interleukin-2 signaling	R-HSA-9020558	5.864252e-01	0.232	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.864252e-01	0.232	0	0
Suppression of apoptosis	R-HSA-9635465	5.864252e-01	0.232	0	0
PECAM1 interactions	R-HSA-210990	5.864252e-01	0.232	0	0
Interleukin-12 family signaling	R-HSA-447115	5.933385e-01	0.227	0	0
Transmission across Chemical Synapses	R-HSA-112315	5.953527e-01	0.225	0	0
EGFR downregulation	R-HSA-182971	5.959859e-01	0.225	0	0
G1 Phase	R-HSA-69236	5.976501e-01	0.224	0	0
Cyclin D associated events in G1	R-HSA-69231	5.976501e-01	0.224	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.986862e-01	0.223	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.986862e-01	0.223	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.986862e-01	0.223	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.986862e-01	0.223	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.986862e-01	0.223	0	0
Extension of Telomeres	R-HSA-180786	6.006899e-01	0.221	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.006899e-01	0.221	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.046937e-01	0.218	0	0
Synthesis of DNA	R-HSA-69239	6.071397e-01	0.217	0	0
MET promotes cell motility	R-HSA-8875878	6.072510e-01	0.217	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.072510e-01	0.217	0	0
Orc1 removal from chromatin	R-HSA-68949	6.083353e-01	0.216	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.083353e-01	0.216	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.083353e-01	0.216	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.094743e-01	0.215	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.094743e-01	0.215	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.094743e-01	0.215	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.094743e-01	0.215	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.094743e-01	0.215	0	0
Interleukin-1 signaling	R-HSA-9020702	6.117965e-01	0.213	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.180498e-01	0.209	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.180498e-01	0.209	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.180498e-01	0.209	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.180498e-01	0.209	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.180498e-01	0.209	0	0
Cellular response to chemical stress	R-HSA-9711123	6.193762e-01	0.208	1	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.201937e-01	0.207	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.237597e-01	0.205	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.237597e-01	0.205	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.237597e-01	0.205	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.237597e-01	0.205	0	0
ERKs are inactivated	R-HSA-202670	6.237597e-01	0.205	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.237597e-01	0.205	0	0
Sodium/Calcium exchangers	R-HSA-425561	6.237597e-01	0.205	0	0
Activation of AMPA receptors	R-HSA-399710	6.269779e-01	0.203	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	6.269779e-01	0.203	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.269779e-01	0.203	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.269779e-01	0.203	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.269779e-01	0.203	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.269779e-01	0.203	0	0
Defective F9 activation	R-HSA-9673221	6.269779e-01	0.203	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.269779e-01	0.203	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	6.269779e-01	0.203	0	0
Activation of AKT2	R-HSA-165158	6.269779e-01	0.203	1	1
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.269779e-01	0.203	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.269779e-01	0.203	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	6.269779e-01	0.203	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	6.269779e-01	0.203	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.269779e-01	0.203	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.269779e-01	0.203	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.269779e-01	0.203	0	0
Regulated Necrosis	R-HSA-5218859	6.269933e-01	0.203	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.269933e-01	0.203	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.284397e-01	0.202	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.284397e-01	0.202	0	0
GAB1 signalosome	R-HSA-180292	6.284397e-01	0.202	0	0
Tie2 Signaling	R-HSA-210993	6.284397e-01	0.202	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.348509e-01	0.197	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.350111e-01	0.197	1	0
Signaling by NOTCH1	R-HSA-1980143	6.353059e-01	0.197	0	0
Regulation of necroptotic cell death	R-HSA-5675482	6.416556e-01	0.193	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.416556e-01	0.193	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.430899e-01	0.192	0	0
MHC class II antigen presentation	R-HSA-2132295	6.475616e-01	0.189	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.484425e-01	0.188	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.484425e-01	0.188	0	0
Aggrephagy	R-HSA-9646399	6.484425e-01	0.188	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.484425e-01	0.188	0	0
Diseases of Immune System	R-HSA-5260271	6.484425e-01	0.188	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.484425e-01	0.188	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.484425e-01	0.188	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.484425e-01	0.188	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.484425e-01	0.188	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	6.550671e-01	0.184	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.556609e-01	0.183	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	6.562117e-01	0.183	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.566331e-01	0.183	0	0
Other interleukin signaling	R-HSA-449836	6.566331e-01	0.183	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.584276e-01	0.181	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.584276e-01	0.181	0	0
MET activates RAS signaling	R-HSA-8851805	6.584276e-01	0.181	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.584276e-01	0.181	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.584276e-01	0.181	0	0
OAS antiviral response	R-HSA-8983711	6.584276e-01	0.181	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.591337e-01	0.181	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.591337e-01	0.181	0	0
Signaling by NOTCH3	R-HSA-9012852	6.614786e-01	0.179	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.680202e-01	0.175	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.680202e-01	0.175	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.698882e-01	0.174	0	0
PKB-mediated events	R-HSA-109703	6.760048e-01	0.170	1	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.760048e-01	0.170	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.760048e-01	0.170	0	0
PDE3B signalling	R-HSA-165160	6.760048e-01	0.170	1	1
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.760048e-01	0.170	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.760048e-01	0.170	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.760048e-01	0.170	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.760048e-01	0.170	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.760048e-01	0.170	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.760048e-01	0.170	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.760048e-01	0.170	0	0
Formation of the Editosome	R-HSA-75094	6.760048e-01	0.170	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	6.760048e-01	0.170	0	0
Synthesis of PS	R-HSA-1483101	6.760048e-01	0.170	0	0
Ceramide signalling	R-HSA-193681	6.760048e-01	0.170	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.760048e-01	0.170	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.760048e-01	0.170	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	6.760048e-01	0.170	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.760048e-01	0.170	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.760048e-01	0.170	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.760048e-01	0.170	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.782052e-01	0.169	0	0
Signaling by FGFR1	R-HSA-5654736	6.782052e-01	0.169	0	0
Sensory processing of sound	R-HSA-9659379	6.793735e-01	0.168	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.822993e-01	0.166	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	6.822993e-01	0.166	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.822993e-01	0.166	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.822993e-01	0.166	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	6.832513e-01	0.165	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.832513e-01	0.165	0	0
Signaling by NODAL	R-HSA-1181150	6.832513e-01	0.165	0	0
Creatine metabolism	R-HSA-71288	6.832513e-01	0.165	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.833250e-01	0.165	1	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.839634e-01	0.165	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.839634e-01	0.165	0	0
Dual Incision in GG-NER	R-HSA-5696400	6.839634e-01	0.165	0	0
Signaling by NOTCH2	R-HSA-1980145	6.839634e-01	0.165	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.868922e-01	0.163	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.868922e-01	0.163	0	0
HIV Transcription Initiation	R-HSA-167161	6.868922e-01	0.163	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.868922e-01	0.163	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.868922e-01	0.163	0	0
Signaling by TGFB family members	R-HSA-9006936	6.885595e-01	0.162	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.904847e-01	0.161	0	0
Adenylate cyclase activating pathway	R-HSA-170660	6.904847e-01	0.161	0	0
Processing of SMDT1	R-HSA-8949664	6.904847e-01	0.161	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.904847e-01	0.161	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.904847e-01	0.161	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.904847e-01	0.161	0	0
Signaling by FGFR2	R-HSA-5654738	6.933416e-01	0.159	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.933416e-01	0.159	0	0
IRS-mediated signalling	R-HSA-112399	6.944128e-01	0.158	1	0
Ca2+ pathway	R-HSA-4086398	7.027198e-01	0.153	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.029399e-01	0.153	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.038068e-01	0.153	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.038068e-01	0.153	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.043362e-01	0.152	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	7.043362e-01	0.152	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.043362e-01	0.152	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.043362e-01	0.152	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.050452e-01	0.152	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.069337e-01	0.151	0	0
PI3K Cascade	R-HSA-109704	7.072757e-01	0.150	1	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.082983e-01	0.150	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.082983e-01	0.150	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.082983e-01	0.150	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.082983e-01	0.150	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.082983e-01	0.150	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.082983e-01	0.150	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.084898e-01	0.150	0	0
Dual incision in TC-NER	R-HSA-6782135	7.100909e-01	0.149	0	0
Selective autophagy	R-HSA-9663891	7.111307e-01	0.148	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.152875e-01	0.146	0	0
Signaling by NOTCH4	R-HSA-9013694	7.166389e-01	0.145	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.185905e-01	0.144	0	0
Erythropoietin activates STAT5	R-HSA-9027283	7.185905e-01	0.144	0	0
STAT5 Activation	R-HSA-9645135	7.185905e-01	0.144	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.185905e-01	0.144	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.185905e-01	0.144	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.185905e-01	0.144	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.185905e-01	0.144	0	0
Neurofascin interactions	R-HSA-447043	7.185905e-01	0.144	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.185905e-01	0.144	0	0
Leukotriene receptors	R-HSA-391906	7.185905e-01	0.144	0	0
Lipid particle organization	R-HSA-8964572	7.185905e-01	0.144	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.200184e-01	0.143	0	0
CRMPs in Sema3A signaling	R-HSA-399956	7.200184e-01	0.143	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.200184e-01	0.143	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.200184e-01	0.143	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.200184e-01	0.143	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.200184e-01	0.143	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.200184e-01	0.143	0	0
Autophagy	R-HSA-9612973	7.222933e-01	0.141	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.224709e-01	0.141	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.227649e-01	0.141	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.227649e-01	0.141	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.227649e-01	0.141	0	0
GPVI-mediated activation cascade	R-HSA-114604	7.227649e-01	0.141	0	0
Membrane Trafficking	R-HSA-199991	7.230912e-01	0.141	1	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.252432e-01	0.140	0	0
mRNA Capping	R-HSA-72086	7.252432e-01	0.140	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.252432e-01	0.140	0	0
Kidney development	R-HSA-9830369	7.275155e-01	0.138	0	0
HCMV Late Events	R-HSA-9610379	7.316108e-01	0.136	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.317944e-01	0.136	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.317944e-01	0.136	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.317944e-01	0.136	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.317944e-01	0.136	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.317944e-01	0.136	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.317944e-01	0.136	0	0
DAP12 interactions	R-HSA-2172127	7.391653e-01	0.131	0	0
Voltage gated Potassium channels	R-HSA-1296072	7.408368e-01	0.130	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.450282e-01	0.128	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	7.471382e-01	0.127	0	0
Translesion synthesis by REV1	R-HSA-110312	7.471382e-01	0.127	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	7.471382e-01	0.127	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.471382e-01	0.127	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.471382e-01	0.127	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	7.471382e-01	0.127	0	0
p38MAPK events	R-HSA-171007	7.471382e-01	0.127	0	0
Biotin transport and metabolism	R-HSA-196780	7.471382e-01	0.127	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.537724e-01	0.123	0	0
FGFR2 alternative splicing	R-HSA-6803529	7.537724e-01	0.123	0	0
Notch-HLH transcription pathway	R-HSA-350054	7.537724e-01	0.123	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.537724e-01	0.123	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.537724e-01	0.123	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.537724e-01	0.123	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.537724e-01	0.123	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.537724e-01	0.123	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	7.538859e-01	0.123	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.538859e-01	0.123	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.539472e-01	0.123	1	1
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.551290e-01	0.122	0	0
Fanconi Anemia Pathway	R-HSA-6783310	7.551290e-01	0.122	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.551290e-01	0.122	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.555809e-01	0.122	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.555809e-01	0.122	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	7.555809e-01	0.122	0	0
Disinhibition of SNARE formation	R-HSA-114516	7.555809e-01	0.122	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.555809e-01	0.122	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.555809e-01	0.122	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.555809e-01	0.122	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.555809e-01	0.122	0	0
VLDL clearance	R-HSA-8964046	7.555809e-01	0.122	0	0
Glycoprotein hormones	R-HSA-209822	7.555809e-01	0.122	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.555809e-01	0.122	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.555809e-01	0.122	0	0
Inositol phosphate metabolism	R-HSA-1483249	7.557538e-01	0.122	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	7.574270e-01	0.121	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.580275e-01	0.120	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.637066e-01	0.117	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	7.637066e-01	0.117	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	7.673966e-01	0.115	0	0
Translation initiation complex formation	R-HSA-72649	7.682586e-01	0.114	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.682586e-01	0.114	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.703661e-01	0.113	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.703661e-01	0.113	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.703661e-01	0.113	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.703661e-01	0.113	0	0
Translesion synthesis by POLI	R-HSA-5656121	7.719682e-01	0.112	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	7.719682e-01	0.112	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	7.719682e-01	0.112	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.719682e-01	0.112	0	0
Killing mechanisms	R-HSA-9664420	7.719682e-01	0.112	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.719682e-01	0.112	0	0
Regulation of BACH1 activity	R-HSA-9708530	7.719682e-01	0.112	0	0
Negative regulation of FLT3	R-HSA-9706369	7.719682e-01	0.112	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.719682e-01	0.112	0	0
Platelet homeostasis	R-HSA-418346	7.739010e-01	0.111	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.742760e-01	0.111	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.742760e-01	0.111	0	0
Formation of the ureteric bud	R-HSA-9830674	7.742760e-01	0.111	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.742760e-01	0.111	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.743467e-01	0.111	0	0
Stabilization of p53	R-HSA-69541	7.743467e-01	0.111	0	0
PPARA activates gene expression	R-HSA-1989781	7.808671e-01	0.107	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	7.813004e-01	0.107	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	7.817364e-01	0.107	0	0
Macroautophagy	R-HSA-1632852	7.844828e-01	0.105	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.877108e-01	0.104	0	0
FGFR1b ligand binding and activation	R-HSA-190370	7.877108e-01	0.104	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.877108e-01	0.104	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.877108e-01	0.104	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.877108e-01	0.104	0	0
Interleukin-9 signaling	R-HSA-8985947	7.877108e-01	0.104	0	0
Regulation by c-FLIP	R-HSA-3371378	7.877108e-01	0.104	0	0
Co-stimulation by ICOS	R-HSA-9927354	7.877108e-01	0.104	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.877108e-01	0.104	0	0
Dimerization of procaspase-8	R-HSA-69416	7.877108e-01	0.104	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.877108e-01	0.104	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	7.877108e-01	0.104	0	0
Glycogen metabolism	R-HSA-8982491	7.898086e-01	0.102	0	0
PKR-mediated signaling	R-HSA-9833482	7.910869e-01	0.102	0	0
TNFs bind their physiological receptors	R-HSA-5669034	7.933568e-01	0.101	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.935280e-01	0.100	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.935280e-01	0.100	0	0
G alpha (s) signalling events	R-HSA-418555	7.936090e-01	0.100	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.946417e-01	0.100	0	0
Translesion synthesis by POLK	R-HSA-5655862	7.946417e-01	0.100	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.946417e-01	0.100	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.946417e-01	0.100	0	0
Synthesis of PG	R-HSA-1483148	7.946417e-01	0.100	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.947925e-01	0.100	1	1
Ribosomal scanning and start codon recognition	R-HSA-72702	7.950329e-01	0.100	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.950329e-01	0.100	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.969751e-01	0.099	0	0
HIV Life Cycle	R-HSA-162587	7.969751e-01	0.099	0	0
Peptide chain elongation	R-HSA-156902	8.016123e-01	0.096	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.021483e-01	0.096	0	0
Maturation of spike protein	R-HSA-9694548	8.044311e-01	0.095	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.047139e-01	0.094	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.110726e-01	0.091	0	0
Acyl chain remodelling of PS	R-HSA-1482801	8.110726e-01	0.091	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	8.113996e-01	0.091	0	0
Degradation of CDH1	R-HSA-9766229	8.118081e-01	0.091	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.133490e-01	0.090	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.133490e-01	0.090	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	8.152966e-01	0.089	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.152966e-01	0.089	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.152966e-01	0.089	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.155941e-01	0.089	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.156188e-01	0.089	0	0
Interleukin-21 signaling	R-HSA-9020958	8.156188e-01	0.089	0	0
CASP8 activity is inhibited	R-HSA-5218900	8.156188e-01	0.089	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.156188e-01	0.089	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	8.156188e-01	0.089	0	0
Regulation of signaling by NODAL	R-HSA-1433617	8.156188e-01	0.089	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.156188e-01	0.089	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	8.156188e-01	0.089	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.156188e-01	0.089	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	8.156188e-01	0.089	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	8.156188e-01	0.089	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.156188e-01	0.089	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	8.156188e-01	0.089	0	0
HCMV Infection	R-HSA-9609646	8.158860e-01	0.088	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.182350e-01	0.087	0	0
Translation of Structural Proteins	R-HSA-9683701	8.182350e-01	0.087	0	0
Cilium Assembly	R-HSA-5617833	8.190606e-01	0.087	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.193964e-01	0.087	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.242425e-01	0.084	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.242834e-01	0.084	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	8.274855e-01	0.082	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.274855e-01	0.082	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.274855e-01	0.082	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.274855e-01	0.082	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.274855e-01	0.082	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.278710e-01	0.082	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.278710e-01	0.082	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.306638e-01	0.081	0	0
Triglyceride metabolism	R-HSA-8979227	8.307013e-01	0.081	0	0
Regulation of beta-cell development	R-HSA-186712	8.307013e-01	0.081	1	0
Unfolded Protein Response (UPR)	R-HSA-381119	8.307859e-01	0.081	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.340716e-01	0.079	0	0
Platelet sensitization by LDL	R-HSA-432142	8.340716e-01	0.079	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.360142e-01	0.078	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.398593e-01	0.076	0	0
DNA replication initiation	R-HSA-68952	8.398593e-01	0.076	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.398593e-01	0.076	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.398593e-01	0.076	0	0
Formation of intermediate mesoderm	R-HSA-9761174	8.398593e-01	0.076	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.398593e-01	0.076	0	0
Arachidonate production from DAG	R-HSA-426048	8.398593e-01	0.076	0	0
Pexophagy	R-HSA-9664873	8.398593e-01	0.076	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.398593e-01	0.076	0	0
Maturation of spike protein	R-HSA-9683686	8.398593e-01	0.076	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.398593e-01	0.076	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	8.398593e-01	0.076	0	0
Peptide hormone biosynthesis	R-HSA-209952	8.398593e-01	0.076	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.398593e-01	0.076	0	0
GABA receptor activation	R-HSA-977443	8.414395e-01	0.075	0	0
RAB geranylgeranylation	R-HSA-8873719	8.414395e-01	0.075	0	0
Oncogene Induced Senescence	R-HSA-2559585	8.414416e-01	0.075	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.426606e-01	0.074	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.426606e-01	0.074	0	0
Translation of Structural Proteins	R-HSA-9694635	8.438026e-01	0.074	0	0
Eukaryotic Translation Elongation	R-HSA-156842	8.481532e-01	0.072	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.511039e-01	0.070	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.511039e-01	0.070	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.511039e-01	0.070	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.541008e-01	0.068	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.541008e-01	0.068	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.549813e-01	0.068	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.566645e-01	0.067	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.609142e-01	0.065	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.609142e-01	0.065	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.609142e-01	0.065	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.609142e-01	0.065	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.609142e-01	0.065	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.609142e-01	0.065	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.609142e-01	0.065	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.609142e-01	0.065	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.609142e-01	0.065	1	1
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.612763e-01	0.065	0	0
Signaling by PDGF	R-HSA-186797	8.612763e-01	0.065	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	8.651233e-01	0.063	1	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.657657e-01	0.063	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.657657e-01	0.063	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.657657e-01	0.063	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.657657e-01	0.063	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.658902e-01	0.063	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.665272e-01	0.062	0	0
Signal transduction by L1	R-HSA-445144	8.665272e-01	0.062	0	0
Nephrin family interactions	R-HSA-373753	8.665272e-01	0.062	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.675495e-01	0.062	0	0
Signaling by MET	R-HSA-6806834	8.698322e-01	0.061	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.704075e-01	0.060	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.717047e-01	0.060	0	0
Cap-dependent Translation Initiation	R-HSA-72737	8.735051e-01	0.059	0	0
Eukaryotic Translation Initiation	R-HSA-72613	8.735051e-01	0.059	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.758661e-01	0.058	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.758661e-01	0.058	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.768520e-01	0.057	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.788716e-01	0.056	0	0
Ion transport by P-type ATPases	R-HSA-936837	8.790370e-01	0.056	0	0
Endosomal/Vacuolar pathway	R-HSA-1236977	8.792019e-01	0.056	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.792019e-01	0.056	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.792019e-01	0.056	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.792019e-01	0.056	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.792019e-01	0.056	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.792019e-01	0.056	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.792019e-01	0.056	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.792019e-01	0.056	0	0
Basigin interactions	R-HSA-210991	8.804700e-01	0.055	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.804700e-01	0.055	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.814274e-01	0.055	0	0
Circadian clock	R-HSA-9909396	8.837700e-01	0.054	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.853128e-01	0.053	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.853128e-01	0.053	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.856372e-01	0.053	0	0
Cellular response to hypoxia	R-HSA-1234174	8.871827e-01	0.052	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.873864e-01	0.052	0	0
Cytoprotection by HMOX1	R-HSA-9707564	8.922299e-01	0.050	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.923194e-01	0.049	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.923194e-01	0.049	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	8.923194e-01	0.049	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.930549e-01	0.049	0	0
Regulation of CDH1 Function	R-HSA-9764561	8.938681e-01	0.049	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.941360e-01	0.049	0	0
Metal ion SLC transporters	R-HSA-425410	8.941360e-01	0.049	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.950859e-01	0.048	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.950859e-01	0.048	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.950859e-01	0.048	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	8.950859e-01	0.048	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.950859e-01	0.048	0	0
Estrogen biosynthesis	R-HSA-193144	8.950859e-01	0.048	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.950859e-01	0.048	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.954981e-01	0.048	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.964629e-01	0.047	0	0
HIV Infection	R-HSA-162906	8.967963e-01	0.047	0	0
Signaling by FGFR	R-HSA-190236	8.984455e-01	0.047	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.030900e-01	0.044	0	0
UCH proteinases	R-HSA-5689603	9.034321e-01	0.044	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.040376e-01	0.044	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.043979e-01	0.044	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.043979e-01	0.044	0	0
Signaling by KIT in disease	R-HSA-9669938	9.043979e-01	0.044	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.043979e-01	0.044	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.051965e-01	0.043	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.051965e-01	0.043	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.072692e-01	0.042	0	0
Signaling by Insulin receptor	R-HSA-74752	9.075335e-01	0.042	1	0
FGFR2c ligand binding and activation	R-HSA-190375	9.088821e-01	0.041	0	0
FGFR1c ligand binding and activation	R-HSA-190373	9.088821e-01	0.041	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.088821e-01	0.041	0	0
FGFR4 ligand binding and activation	R-HSA-190322	9.088821e-01	0.041	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.088821e-01	0.041	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.088821e-01	0.041	0	0
Acetylcholine binding and downstream events	R-HSA-181431	9.088821e-01	0.041	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.088821e-01	0.041	0	0
Chylomicron remodeling	R-HSA-8963901	9.088821e-01	0.041	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	9.088821e-01	0.041	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.088821e-01	0.041	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	9.088821e-01	0.041	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	9.088821e-01	0.041	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	9.088821e-01	0.041	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	9.088821e-01	0.041	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	9.088821e-01	0.041	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.088821e-01	0.041	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.089007e-01	0.041	0	0
Regulation of RAS by GAPs	R-HSA-5658442	9.100334e-01	0.041	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.122635e-01	0.040	0	0
Developmental Cell Lineages	R-HSA-9734767	9.129797e-01	0.040	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.132031e-01	0.039	0	0
Intra-Golgi traffic	R-HSA-6811438	9.132708e-01	0.039	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.132708e-01	0.039	0	0
Carnitine shuttle	R-HSA-200425	9.146079e-01	0.039	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.146079e-01	0.039	0	0
Growth hormone receptor signaling	R-HSA-982772	9.146079e-01	0.039	0	0
Selenocysteine synthesis	R-HSA-2408557	9.153267e-01	0.038	0	0
Host Interactions of HIV factors	R-HSA-162909	9.179161e-01	0.037	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.198026e-01	0.036	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.199814e-01	0.036	0	0
Leishmania infection	R-HSA-9658195	9.199814e-01	0.036	0	0
Activation of GABAB receptors	R-HSA-991365	9.207258e-01	0.036	0	0
GABA B receptor activation	R-HSA-977444	9.207258e-01	0.036	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.207258e-01	0.036	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.208648e-01	0.036	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.208648e-01	0.036	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.208648e-01	0.036	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.208648e-01	0.036	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.208648e-01	0.036	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.208648e-01	0.036	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.208648e-01	0.036	0	0
Malate-aspartate shuttle	R-HSA-9856872	9.208648e-01	0.036	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.208648e-01	0.036	0	0
Non-canonical inflammasome activation	R-HSA-9686114	9.208648e-01	0.036	0	0
Ciprofloxacin ADME	R-HSA-9793528	9.208648e-01	0.036	0	0
P2Y receptors	R-HSA-417957	9.208648e-01	0.036	0	0
Zinc transporters	R-HSA-435354	9.208648e-01	0.036	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.227274e-01	0.035	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.237978e-01	0.034	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.237978e-01	0.034	0	0
Viral mRNA Translation	R-HSA-192823	9.252145e-01	0.034	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.274325e-01	0.033	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.274325e-01	0.033	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.274325e-01	0.033	0	0
Mitophagy	R-HSA-5205647	9.274325e-01	0.033	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.278180e-01	0.033	0	0
Mitochondrial protein import	R-HSA-1268020	9.278180e-01	0.033	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.278180e-01	0.033	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.284766e-01	0.032	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.297777e-01	0.032	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.299528e-01	0.032	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.299528e-01	0.032	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.311691e-01	0.031	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.312723e-01	0.031	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.312723e-01	0.031	0	0
Protein lipoylation	R-HSA-9857492	9.312723e-01	0.031	0	0
Signaling by Activin	R-HSA-1502540	9.312723e-01	0.031	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.312723e-01	0.031	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.312723e-01	0.031	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.312723e-01	0.031	0	0
Other semaphorin interactions	R-HSA-416700	9.312723e-01	0.031	0	0
Protein methylation	R-HSA-8876725	9.312723e-01	0.031	0	0
DNA Damage Reversal	R-HSA-73942	9.312723e-01	0.031	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.320290e-01	0.031	0	0
G protein gated Potassium channels	R-HSA-1296059	9.320290e-01	0.031	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.320290e-01	0.031	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.320290e-01	0.031	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.320290e-01	0.031	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.343903e-01	0.029	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.343903e-01	0.029	0	0
Downstream TCR signaling	R-HSA-202424	9.367738e-01	0.028	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.394221e-01	0.027	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.394221e-01	0.027	0	0
Abacavir ADME	R-HSA-2161522	9.394221e-01	0.027	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.397588e-01	0.027	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.403116e-01	0.027	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.403116e-01	0.027	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.403116e-01	0.027	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.403116e-01	0.027	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.403116e-01	0.027	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	9.403116e-01	0.027	0	0
Activation of SMO	R-HSA-5635838	9.403116e-01	0.027	0	0
Fructose catabolism	R-HSA-70350	9.403116e-01	0.027	0	0
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.403116e-01	0.027	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.403116e-01	0.027	0	0
Atorvastatin ADME	R-HSA-9754706	9.403116e-01	0.027	0	0
HSF1 activation	R-HSA-3371511	9.407277e-01	0.027	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.409472e-01	0.026	0	0
Interferon Signaling	R-HSA-913531	9.409831e-01	0.026	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.410946e-01	0.026	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	9.417219e-01	0.026	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	9.434000e-01	0.025	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.451130e-01	0.025	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.460468e-01	0.024	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.460468e-01	0.024	0	0
Signaling by BMP	R-HSA-201451	9.460468e-01	0.024	0	0
Insulin processing	R-HSA-264876	9.460468e-01	0.024	0	0
Degradation of DVL	R-HSA-4641258	9.464935e-01	0.024	0	0
Degradation of AXIN	R-HSA-4641257	9.464935e-01	0.024	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.464935e-01	0.024	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.464935e-01	0.024	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.481624e-01	0.023	0	0
Glycine degradation	R-HSA-6783984	9.481624e-01	0.023	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.481624e-01	0.023	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.481624e-01	0.023	0	0
Response to metal ions	R-HSA-5660526	9.481624e-01	0.023	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.481624e-01	0.023	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.485283e-01	0.023	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.487692e-01	0.023	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.500284e-01	0.022	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.505648e-01	0.022	1	0
Influenza Infection	R-HSA-168255	9.511520e-01	0.022	0	0
Pyrimidine salvage	R-HSA-73614	9.519774e-01	0.021	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.526933e-01	0.021	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.528025e-01	0.021	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.549810e-01	0.020	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.549810e-01	0.020	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.549810e-01	0.020	0	0
Glycogen storage diseases	R-HSA-3229121	9.549810e-01	0.020	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	9.549810e-01	0.020	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.549810e-01	0.020	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.549810e-01	0.020	0	0
Choline catabolism	R-HSA-6798163	9.549810e-01	0.020	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.564917e-01	0.019	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.572818e-01	0.019	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.572818e-01	0.019	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.572818e-01	0.019	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.609031e-01	0.017	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.609031e-01	0.017	0	0
FGFR1 ligand binding and activation	R-HSA-190242	9.609031e-01	0.017	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.609031e-01	0.017	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.609031e-01	0.017	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.609031e-01	0.017	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.609031e-01	0.017	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.609031e-01	0.017	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.609031e-01	0.017	0	0
Interferon gamma signaling	R-HSA-877300	9.619223e-01	0.017	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.620220e-01	0.017	0	0
Immune System	R-HSA-168256	9.625570e-01	0.017	1	0
COPI-mediated anterograde transport	R-HSA-6807878	9.643386e-01	0.016	0	0
SARS-CoV Infections	R-HSA-9679506	9.647057e-01	0.016	1	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.647179e-01	0.016	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.652163e-01	0.015	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.655364e-01	0.015	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.659047e-01	0.015	0	0
The phototransduction cascade	R-HSA-2514856	9.659047e-01	0.015	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.660464e-01	0.015	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.660464e-01	0.015	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.660464e-01	0.015	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.660464e-01	0.015	0	0
Regulation of signaling by CBL	R-HSA-912631	9.660464e-01	0.015	0	0
Diseases of hemostasis	R-HSA-9671793	9.660464e-01	0.015	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.660464e-01	0.015	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.662547e-01	0.015	0	0
Phospholipid metabolism	R-HSA-1483257	9.687280e-01	0.014	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.700313e-01	0.013	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.705134e-01	0.013	0	0
Glycogen synthesis	R-HSA-3322077	9.705134e-01	0.013	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.705134e-01	0.013	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.705134e-01	0.013	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.705134e-01	0.013	0	0
Negative regulation of MET activity	R-HSA-6807004	9.705134e-01	0.013	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.705134e-01	0.013	0	0
Ribosome-associated quality control	R-HSA-9948299	9.705705e-01	0.013	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.719476e-01	0.012	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.725241e-01	0.012	0	0
GPCR downstream signalling	R-HSA-388396	9.730842e-01	0.012	1	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.733986e-01	0.012	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.733986e-01	0.012	0	0
Parasite infection	R-HSA-9664407	9.741430e-01	0.011	0	0
Leishmania phagocytosis	R-HSA-9664417	9.741430e-01	0.011	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.741430e-01	0.011	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.743563e-01	0.011	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.743563e-01	0.011	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.743563e-01	0.011	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.743929e-01	0.011	0	0
G-protein activation	R-HSA-202040	9.743929e-01	0.011	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.743929e-01	0.011	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.743929e-01	0.011	0	0
Phenylalanine metabolism	R-HSA-8964208	9.743929e-01	0.011	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.743929e-01	0.011	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.743929e-01	0.011	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.743929e-01	0.011	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.763989e-01	0.010	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.763989e-01	0.010	0	0
Heme degradation	R-HSA-189483	9.763989e-01	0.010	0	0
Proteasome assembly	R-HSA-9907900	9.769709e-01	0.010	0	0
Surfactant metabolism	R-HSA-5683826	9.769709e-01	0.010	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.769758e-01	0.010	0	0
G alpha (z) signalling events	R-HSA-418597	9.769758e-01	0.010	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.775087e-01	0.010	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.777622e-01	0.010	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.777622e-01	0.010	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.780135e-01	0.010	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.790704e-01	0.009	0	0
eNOS activation	R-HSA-203615	9.790704e-01	0.009	0	0
Signal amplification	R-HSA-392518	9.790704e-01	0.009	0	0
Somitogenesis	R-HSA-9824272	9.793304e-01	0.009	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.799761e-01	0.009	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.806883e-01	0.008	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.806883e-01	0.008	0	0
Fructose metabolism	R-HSA-5652084	9.806883e-01	0.008	0	0
Ethanol oxidation	R-HSA-71384	9.806883e-01	0.008	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.806883e-01	0.008	0	0
LDL clearance	R-HSA-8964038	9.806883e-01	0.008	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.806883e-01	0.008	0	0
PCP/CE pathway	R-HSA-4086400	9.812726e-01	0.008	0	0
ABC transporter disorders	R-HSA-5619084	9.812726e-01	0.008	0	0
Interleukin-10 signaling	R-HSA-6783783	9.812726e-01	0.008	0	0
PERK regulates gene expression	R-HSA-381042	9.814477e-01	0.008	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.814477e-01	0.008	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.814477e-01	0.008	0	0
Regulation of Apoptosis	R-HSA-169911	9.814477e-01	0.008	0	0
G alpha (q) signalling events	R-HSA-416476	9.814584e-01	0.008	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.827892e-01	0.008	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.828734e-01	0.008	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.832296e-01	0.007	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.832296e-01	0.007	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.832296e-01	0.007	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.832296e-01	0.007	0	0
Biosynthesis of maresins	R-HSA-9018682	9.832296e-01	0.007	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.832296e-01	0.007	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.835619e-01	0.007	0	0
Glycosphingolipid transport	R-HSA-9845576	9.835619e-01	0.007	0	0
ER-Phagosome pathway	R-HSA-1236974	9.841862e-01	0.007	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.845955e-01	0.007	0	0
Intraflagellar transport	R-HSA-5620924	9.851022e-01	0.007	0	0
Gluconeogenesis	R-HSA-70263	9.851022e-01	0.007	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.854366e-01	0.006	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.854366e-01	0.006	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.854366e-01	0.006	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.854366e-01	0.006	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.854366e-01	0.006	0	0
Complex III assembly	R-HSA-9865881	9.854366e-01	0.006	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.854411e-01	0.006	0	0
NCAM1 interactions	R-HSA-419037	9.854411e-01	0.006	0	0
Neurotransmitter release cycle	R-HSA-112310	9.854914e-01	0.006	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.860867e-01	0.006	0	0
Metabolism of cofactors	R-HSA-8978934	9.862987e-01	0.006	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.866562e-01	0.006	0	0
Cellular response to starvation	R-HSA-9711097	9.866641e-01	0.006	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.869274e-01	0.006	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.871105e-01	0.006	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.873532e-01	0.006	0	0
Hyaluronan degradation	R-HSA-2160916	9.873532e-01	0.006	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.873532e-01	0.006	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.873532e-01	0.006	0	0
Laminin interactions	R-HSA-3000157	9.873532e-01	0.006	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.873532e-01	0.006	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.875549e-01	0.005	0	0
Neddylation	R-HSA-8951664	9.885864e-01	0.005	0	0
Pentose phosphate pathway	R-HSA-71336	9.885928e-01	0.005	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.885928e-01	0.005	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.885928e-01	0.005	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.888282e-01	0.005	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.890177e-01	0.005	0	0
Urea cycle	R-HSA-70635	9.890177e-01	0.005	0	0
Sphingolipid catabolism	R-HSA-9845614	9.890177e-01	0.005	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.890177e-01	0.005	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.893099e-01	0.005	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.899083e-01	0.004	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.904632e-01	0.004	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.904632e-01	0.004	0	0
Triglyceride biosynthesis	R-HSA-75109	9.904632e-01	0.004	0	0
Synthesis of PE	R-HSA-1483213	9.904632e-01	0.004	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.904632e-01	0.004	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.906368e-01	0.004	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.907012e-01	0.004	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.910753e-01	0.004	0	0
Hemostasis	R-HSA-109582	9.911052e-01	0.004	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	9.912930e-01	0.004	0	0
Prednisone ADME	R-HSA-9757110	9.917185e-01	0.004	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.917185e-01	0.004	0	0
Insulin receptor recycling	R-HSA-77387	9.917185e-01	0.004	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.917185e-01	0.004	0	0
RSV-host interactions	R-HSA-9833110	9.920091e-01	0.003	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.921099e-01	0.003	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.921782e-01	0.003	0	0
Neutrophil degranulation	R-HSA-6798695	9.924140e-01	0.003	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.925074e-01	0.003	0	0
Thyroxine biosynthesis	R-HSA-209968	9.928087e-01	0.003	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.928087e-01	0.003	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.928087e-01	0.003	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.930269e-01	0.003	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.930269e-01	0.003	0	0
Neurotransmitter clearance	R-HSA-112311	9.937554e-01	0.003	0	0
Defensins	R-HSA-1461973	9.938393e-01	0.003	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.938761e-01	0.003	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.939060e-01	0.003	0	0
rRNA processing	R-HSA-72312	9.941867e-01	0.003	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.945775e-01	0.002	0	0
Cargo concentration in the ER	R-HSA-5694530	9.945775e-01	0.002	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.945775e-01	0.002	0	0
Peptide hormone metabolism	R-HSA-2980736	9.947381e-01	0.002	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.950236e-01	0.002	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.951033e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.951033e-01	0.002	0	0
Platelet degranulation	R-HSA-114608	9.951439e-01	0.002	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.951466e-01	0.002	0	0
Peroxisomal protein import	R-HSA-9033241	9.956712e-01	0.002	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.956712e-01	0.002	0	0
Protein folding	R-HSA-391251	9.957695e-01	0.002	0	0
Recycling of bile acids and salts	R-HSA-159418	9.959114e-01	0.002	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.959114e-01	0.002	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.961405e-01	0.002	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.962574e-01	0.002	0	0
Vesicle-mediated transport	R-HSA-5653656	9.963354e-01	0.002	1	0
Collagen formation	R-HSA-1474290	9.965150e-01	0.002	0	0
Nucleotide salvage	R-HSA-8956321	9.965601e-01	0.001	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.969173e-01	0.001	0	0
Hyaluronan metabolism	R-HSA-2142845	9.969173e-01	0.001	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.969173e-01	0.001	0	0
Formation of the cornified envelope	R-HSA-6809371	9.971250e-01	0.001	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.971406e-01	0.001	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.973232e-01	0.001	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.973232e-01	0.001	0	0
Signaling by GPCR	R-HSA-372790	9.973952e-01	0.001	1	0
Interferon alpha/beta signaling	R-HSA-909733	9.974772e-01	0.001	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.976758e-01	0.001	0	0
Protein localization	R-HSA-9609507	9.976888e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.977361e-01	0.001	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.978817e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.979385e-01	0.001	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.979819e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.979819e-01	0.001	0	0
Lysine catabolism	R-HSA-71064	9.979819e-01	0.001	0	0
Collagen chain trimerization	R-HSA-8948216	9.979819e-01	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	9.979819e-01	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.982418e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.982477e-01	0.001	0	0
Elastic fibre formation	R-HSA-1566948	9.982477e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.982876e-01	0.001	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.984772e-01	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.984785e-01	0.001	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.984785e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.985389e-01	0.001	0	0
Paracetamol ADME	R-HSA-9753281	9.986358e-01	0.001	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.986789e-01	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.987987e-01	0.001	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.988530e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.989309e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.989424e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.989424e-01	0.000	0	0
Heme biosynthesis	R-HSA-189451	9.990041e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.990504e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.990600e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.990600e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992411e-01	0.000	0	0
Pyrimidine catabolism	R-HSA-73621	9.992492e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.992513e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.992791e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.992791e-01	0.000	0	0
SLC transporter disorders	R-HSA-5619102	9.992822e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.993355e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.993355e-01	0.000	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.993482e-01	0.000	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993482e-01	0.000	0	0
Collagen degradation	R-HSA-1442490	9.993659e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.993822e-01	0.000	1	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.994341e-01	0.000	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.995086e-01	0.000	0	0
Integrin cell surface interactions	R-HSA-216083	9.995361e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.995734e-01	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.996296e-01	0.000	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.996784e-01	0.000	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.996784e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.996810e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.997017e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.997071e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.997071e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.997208e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997252e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.997427e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.998026e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998068e-01	0.000	0	0
ECM proteoglycans	R-HSA-3000178	9.998256e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.998256e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.998468e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.998620e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.998655e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.998683e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.998740e-01	0.000	0	0
Digestion	R-HSA-8935690	9.998805e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.999238e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999242e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.999300e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999304e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.999321e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.999411e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999556e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999614e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999644e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999665e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999685e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999704e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999723e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999755e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999835e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999851e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.999857e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999930e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999938e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999943e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999946e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999954e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999965e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999965e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999969e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999977e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999985e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999989e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999993e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999995e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999995e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999998e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999998e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999998e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999998e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999999e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999999e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	1	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	1	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Estrogen-dependent gene expression	R-HSA-9018519	1.353440e-09	8.869	0	0
Cell Cycle	R-HSA-1640170	3.097310e-09	8.509	1	0
M Phase	R-HSA-68886	1.288254e-08	7.890	0	0
Cell Cycle Checkpoints	R-HSA-69620	3.806871e-08	7.419	0	0
Cellular Senescence	R-HSA-2559583	4.573834e-08	7.340	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.589705e-08	7.338	1	1
Transcriptional regulation by RUNX1	R-HSA-8878171	4.970845e-08	7.304	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	6.500433e-08	7.187	0	0
Cell Cycle, Mitotic	R-HSA-69278	6.238041e-08	7.205	1	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.963116e-07	6.707	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.223794e-07	6.653	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.126719e-07	6.505	0	0
Chromatin modifying enzymes	R-HSA-3247509	3.066971e-07	6.513	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.847320e-07	6.546	1	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.282784e-07	6.484	0	0
Signal Transduction	R-HSA-162582	3.780428e-07	6.422	1	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.078761e-07	6.389	0	0
Chromatin organization	R-HSA-4839726	7.552620e-07	6.122	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.026923e-06	5.988	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.213171e-06	5.916	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.501681e-06	5.823	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.597802e-06	5.796	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.597802e-06	5.796	0	0
PRC2 methylates histones and DNA	R-HSA-212300	1.720266e-06	5.764	0	0
Mitotic Prophase	R-HSA-68875	1.844050e-06	5.734	0	0
ESR-mediated signaling	R-HSA-8939211	2.084429e-06	5.681	1	0
Apoptotic execution phase	R-HSA-75153	2.338177e-06	5.631	0	0
Axon guidance	R-HSA-422475	2.584990e-06	5.588	0	0
DNA methylation	R-HSA-5334118	2.646466e-06	5.577	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.915905e-06	5.535	0	0
Cell junction organization	R-HSA-446728	3.350107e-06	5.475	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.507769e-06	5.455	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.831476e-06	5.316	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.096136e-06	5.293	1	1
Transcriptional regulation by small RNAs	R-HSA-5578749	5.952005e-06	5.225	0	0
Packaging Of Telomere Ends	R-HSA-171306	6.304699e-06	5.200	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	6.304699e-06	5.200	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.972126e-06	5.157	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.955289e-06	5.099	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	8.760262e-06	5.057	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.424769e-06	5.026	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.080568e-05	4.966	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.268858e-05	4.897	0	0
Cell-Cell communication	R-HSA-1500931	1.347139e-05	4.871	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.386714e-05	4.858	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.672994e-05	4.777	0	0
Nervous system development	R-HSA-9675108	1.680063e-05	4.775	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.165736e-05	4.664	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.476343e-05	4.606	0	0
Nucleosome assembly	R-HSA-774815	2.476343e-05	4.606	0	0
Adherens junctions interactions	R-HSA-418990	2.559550e-05	4.592	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.547789e-05	4.594	0	0
NRAGE signals death through JNK	R-HSA-193648	2.418277e-05	4.616	0	0
Cleavage of the damaged purine	R-HSA-110331	3.705247e-05	4.431	0	0
Meiotic synapsis	R-HSA-1221632	4.219293e-05	4.375	0	0
Depurination	R-HSA-73927	4.753528e-05	4.323	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.419509e-05	4.266	0	0
Defective pyroptosis	R-HSA-9710421	5.468518e-05	4.262	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.711182e-05	4.243	1	0
HDACs deacetylate histones	R-HSA-3214815	6.315161e-05	4.200	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.549243e-05	4.122	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.655207e-05	4.116	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.615403e-05	4.017	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.615403e-05	4.017	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.968938e-05	4.001	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.013797e-04	3.994	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.015417e-04	3.993	1	0
HATs acetylate histones	R-HSA-3214847	1.075975e-04	3.968	0	0
Diseases of programmed cell death	R-HSA-9645723	1.089924e-04	3.963	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.283995e-04	3.891	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.283995e-04	3.891	0	0
Cell-cell junction organization	R-HSA-421270	1.284373e-04	3.891	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.349072e-04	3.870	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.352335e-04	3.869	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	1.488260e-04	3.827	0	0
Depyrimidination	R-HSA-73928	1.488260e-04	3.827	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.603479e-04	3.795	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.772127e-04	3.752	0	0
Mitotic Anaphase	R-HSA-68882	1.687003e-04	3.773	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.772127e-04	3.752	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.839852e-04	3.735	0	0
G2/M Checkpoints	R-HSA-69481	1.927671e-04	3.715	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.259956e-04	3.646	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.340855e-04	3.631	1	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.614292e-04	3.583	0	0
Meiotic recombination	R-HSA-912446	2.783051e-04	3.555	0	0
Mitotic Prometaphase	R-HSA-68877	2.932318e-04	3.533	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	3.202794e-04	3.494	0	0
PKMTs methylate histone lysines	R-HSA-3214841	3.216965e-04	3.493	0	0
Gene Silencing by RNA	R-HSA-211000	3.430890e-04	3.465	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.721928e-04	3.429	0	0
Meiosis	R-HSA-1500620	3.986020e-04	3.399	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	4.182762e-04	3.379	0	0
Chromosome Maintenance	R-HSA-73886	4.299623e-04	3.367	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.729062e-04	3.325	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.995765e-04	3.301	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.281057e-04	3.277	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	5.494112e-04	3.260	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.494112e-04	3.260	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	6.160520e-04	3.210	0	0
Cell-extracellular matrix interactions	R-HSA-446353	6.204130e-04	3.207	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.891139e-04	3.162	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	6.939459e-04	3.159	0	0
Signaling by WNT	R-HSA-195721	7.173004e-04	3.144	1	0
mRNA Splicing	R-HSA-72172	8.019227e-04	3.096	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	7.969170e-04	3.099	0	0
Regulation of endogenous retroelements	R-HSA-9842860	8.757155e-04	3.058	0	0
mRNA 3'-end processing	R-HSA-72187	9.562385e-04	3.019	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.562385e-04	3.019	0	0
DNA Replication Pre-Initiation	R-HSA-69002	9.684177e-04	3.014	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	9.262733e-04	3.033	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.684177e-04	3.014	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.829732e-04	3.007	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	9.427324e-04	3.026	0	0
Death Receptor Signaling	R-HSA-73887	9.233698e-04	3.035	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.022518e-03	2.990	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.098490e-03	2.959	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.098490e-03	2.959	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.142032e-03	2.942	0	0
Cellular responses to stimuli	R-HSA-8953897	1.199516e-03	2.921	1	0
Kinesins	R-HSA-983189	1.225859e-03	2.912	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.418806e-03	2.848	0	0
Reproduction	R-HSA-1474165	1.330791e-03	2.876	0	0
Homology Directed Repair	R-HSA-5693538	1.434579e-03	2.843	0	0
Signaling by Hippo	R-HSA-2028269	1.561967e-03	2.806	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.639564e-03	2.785	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.796344e-03	2.746	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.020294e-03	2.695	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.208607e-03	2.656	1	0
G alpha (12/13) signalling events	R-HSA-416482	2.248564e-03	2.648	0	0
DAG and IP3 signaling	R-HSA-1489509	2.374358e-03	2.624	0	0
Telomere Maintenance	R-HSA-157579	2.437457e-03	2.613	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.580064e-03	2.588	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.939123e-03	2.532	0	0
DCC mediated attractive signaling	R-HSA-418885	2.801580e-03	2.553	0	0
Cellular responses to stress	R-HSA-2262752	3.132706e-03	2.504	1	0
Epigenetic regulation of gene expression	R-HSA-212165	3.255850e-03	2.487	0	0
PLC beta mediated events	R-HSA-112043	3.557577e-03	2.449	0	0
Calmodulin induced events	R-HSA-111933	3.639749e-03	2.439	0	0
CaM pathway	R-HSA-111997	3.639749e-03	2.439	0	0
Heme signaling	R-HSA-9707616	4.048078e-03	2.393	0	0
Ca-dependent events	R-HSA-111996	4.052131e-03	2.392	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.604962e-03	2.337	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.323274e-03	2.364	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.649962e-03	2.333	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.479514e-03	2.349	1	1
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.649962e-03	2.333	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.796483e-03	2.319	0	0
Rab regulation of trafficking	R-HSA-9007101	5.312040e-03	2.275	1	0
Interaction between L1 and Ankyrins	R-HSA-445095	5.447596e-03	2.264	0	0
Signaling by VEGF	R-HSA-194138	5.932847e-03	2.227	1	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.162000e-03	2.145	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.162000e-03	2.145	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.162000e-03	2.145	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.162000e-03	2.145	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	6.646716e-03	2.177	0	0
Signaling by ROBO receptors	R-HSA-376176	6.811315e-03	2.167	0	0
Membrane Trafficking	R-HSA-199991	7.074747e-03	2.150	1	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.086586e-03	2.150	0	0
Signaling by ALK in cancer	R-HSA-9700206	7.086586e-03	2.150	0	0
G-protein mediated events	R-HSA-112040	7.394284e-03	2.131	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	7.709021e-03	2.113	0	0
FLT3 Signaling	R-HSA-9607240	7.992537e-03	2.097	1	1
Deubiquitination	R-HSA-5688426	8.102165e-03	2.091	0	0
Ub-specific processing proteases	R-HSA-5689880	8.146066e-03	2.089	0	0
DNA Repair	R-HSA-73894	8.864795e-03	2.052	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.957450e-03	2.048	0	0
Rap1 signalling	R-HSA-392517	9.577231e-03	2.019	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.016991e-02	1.993	1	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.467717e-03	2.024	0	0
RET signaling	R-HSA-8853659	1.011866e-02	1.995	0	0
L1CAM interactions	R-HSA-373760	9.359648e-03	2.029	0	0
Base Excision Repair	R-HSA-73884	9.092544e-03	2.041	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.097907e-02	1.959	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.106816e-02	1.956	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.106816e-02	1.956	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.106816e-02	1.956	0	0
HDMs demethylate histones	R-HSA-3214842	1.156034e-02	1.937	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.175616e-02	1.930	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.175716e-02	1.930	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.198554e-02	1.921	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.205915e-02	1.919	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.205915e-02	1.919	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	1.230427e-02	1.910	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.312844e-02	1.882	0	0
Glycolysis	R-HSA-70171	1.341341e-02	1.872	0	0
Post NMDA receptor activation events	R-HSA-438064	1.388260e-02	1.858	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.402846e-02	1.853	0	0
Signaling by NOTCH	R-HSA-157118	1.431037e-02	1.844	0	0
Amyloid fiber formation	R-HSA-977225	1.466710e-02	1.834	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.634672e-02	1.787	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.634672e-02	1.787	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.634672e-02	1.787	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.634672e-02	1.787	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.634672e-02	1.787	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.681222e-02	1.774	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.608329e-02	1.794	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.489489e-02	1.827	0	0
Protein ubiquitination	R-HSA-8852135	1.698733e-02	1.770	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.715082e-02	1.766	0	0
DNA Replication	R-HSA-69306	1.763976e-02	1.754	0	0
Apoptosis	R-HSA-109581	1.843817e-02	1.734	1	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.855548e-02	1.732	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.003468e-02	1.698	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.056460e-02	1.687	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.099894e-02	1.678	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.099894e-02	1.678	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.100105e-02	1.678	0	0
Specification of primordial germ cells	R-HSA-9827857	2.122488e-02	1.673	0	0
S Phase	R-HSA-69242	2.170999e-02	1.663	1	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.202466e-02	1.657	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.266429e-02	1.645	0	0
Formation of annular gap junctions	R-HSA-196025	2.285621e-02	1.641	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.561774e-02	1.591	0	0
Deadenylation of mRNA	R-HSA-429947	2.819654e-02	1.550	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.561774e-02	1.591	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.662466e-02	1.575	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.819654e-02	1.550	0	0
Co-inhibition by PD-1	R-HSA-389948	2.476890e-02	1.606	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.527324e-02	1.597	1	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.561774e-02	1.591	0	0
TBC/RABGAPs	R-HSA-8854214	2.864237e-02	1.543	0	0
Neurodegenerative Diseases	R-HSA-8863678	2.819654e-02	1.550	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.819654e-02	1.550	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.479328e-02	1.606	1	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.922390e-02	1.534	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.923314e-02	1.534	0	0
Gap junction degradation	R-HSA-190873	3.006719e-02	1.522	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.006719e-02	1.522	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.057672e-02	1.515	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.109761e-02	1.507	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.109761e-02	1.507	0	0
Sema4D in semaphorin signaling	R-HSA-400685	3.275118e-02	1.485	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	3.334269e-02	1.477	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.453895e-02	1.462	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.453895e-02	1.462	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.453895e-02	1.462	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.612430e-02	1.442	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.702981e-02	1.431	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	3.702981e-02	1.431	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.777177e-02	1.423	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.785878e-02	1.422	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	3.959475e-02	1.402	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	4.059603e-02	1.392	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.141557e-02	1.383	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.330704e-02	1.363	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.330704e-02	1.363	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	4.330704e-02	1.363	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.327259e-02	1.364	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.327259e-02	1.364	0	0
HIV elongation arrest and recovery	R-HSA-167287	4.926541e-02	1.307	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	4.926541e-02	1.307	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.276745e-02	1.369	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.619286e-02	1.335	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.619286e-02	1.335	0	0
HCMV Early Events	R-HSA-9609690	4.825899e-02	1.316	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.041292e-02	1.297	1	1
Recycling pathway of L1	R-HSA-437239	4.380890e-02	1.358	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	4.619286e-02	1.335	0	0
Hedgehog 'off' state	R-HSA-5610787	4.501683e-02	1.347	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.330704e-02	1.363	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.624868e-02	1.335	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.997422e-02	1.301	1	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.327259e-02	1.364	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.831752e-02	1.316	0	0
MAPK family signaling cascades	R-HSA-5683057	4.679597e-02	1.330	0	0
Semaphorin interactions	R-HSA-373755	4.619286e-02	1.335	0	0
MAP2K and MAPK activation	R-HSA-5674135	5.120701e-02	1.291	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	5.120701e-02	1.291	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.139463e-02	1.289	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.380179e-02	1.269	0	0
Regulation of CDH1 Function	R-HSA-9764561	5.416848e-02	1.266	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.448200e-02	1.264	1	1
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.472254e-02	1.262	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.472254e-02	1.262	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.472254e-02	1.262	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	5.505441e-02	1.259	0	0
Glucose metabolism	R-HSA-70326	5.527980e-02	1.257	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.754934e-02	1.240	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.754934e-02	1.240	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.876865e-02	1.231	0	0
Signaling by AXIN mutants	R-HSA-4839735	5.892659e-02	1.230	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.892659e-02	1.230	0	0
AURKA Activation by TPX2	R-HSA-8854518	5.911026e-02	1.228	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.408924e-02	1.193	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	6.535259e-02	1.185	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	6.578638e-02	1.182	1	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.650707e-02	1.177	1	1
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.678321e-02	1.175	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.370692e-02	1.132	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	7.370692e-02	1.132	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.370692e-02	1.132	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.409949e-02	1.075	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.417829e-02	1.130	0	0
Ephrin signaling	R-HSA-3928664	7.417829e-02	1.130	0	0
PKA activation	R-HSA-163615	7.417829e-02	1.130	0	0
PKA activation in glucagon signalling	R-HSA-164378	7.417829e-02	1.130	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	8.249568e-02	1.084	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	8.249568e-02	1.084	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.091625e-02	1.092	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	6.941299e-02	1.159	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	8.192004e-02	1.087	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.192004e-02	1.087	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.192004e-02	1.087	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.547331e-02	1.122	0	0
FOXO-mediated transcription	R-HSA-9614085	7.219854e-02	1.141	1	0
Clathrin-mediated endocytosis	R-HSA-8856828	6.919150e-02	1.160	0	0
Signaling by RAS mutants	R-HSA-6802949	8.192004e-02	1.087	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	7.977710e-02	1.098	1	1
Netrin-1 signaling	R-HSA-373752	6.854487e-02	1.164	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.409949e-02	1.075	0	0
Cellular response to heat stress	R-HSA-3371556	6.944409e-02	1.158	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.630083e-02	1.117	1	1
Disorders of Nervous System Development	R-HSA-9697154	7.093883e-02	1.149	0	0
Pervasive developmental disorders	R-HSA-9005895	7.093883e-02	1.149	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.093883e-02	1.149	0	0
Regulation of TP53 Activity	R-HSA-5633007	6.731370e-02	1.172	1	0
Interleukin-7 signaling	R-HSA-1266695	8.249568e-02	1.084	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.091625e-02	1.092	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	7.143802e-02	1.146	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.370692e-02	1.132	0	0
G2/M Transition	R-HSA-69275	6.860973e-02	1.164	0	0
Mitotic G2-G2/M phases	R-HSA-453274	7.488411e-02	1.126	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.409949e-02	1.075	0	0
Programmed Cell Death	R-HSA-5357801	7.498125e-02	1.125	1	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	8.474088e-02	1.072	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.514212e-02	1.070	0	0
Maturation of nucleoprotein	R-HSA-9694631	8.514212e-02	1.070	0	0
Integrin signaling	R-HSA-354192	8.683620e-02	1.061	0	0
Activation of ATR in response to replication stress	R-HSA-176187	8.683620e-02	1.061	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.683620e-02	1.061	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	8.683620e-02	1.061	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.683620e-02	1.061	0	0
Gene expression (Transcription)	R-HSA-74160	8.727834e-02	1.059	1	0
HIV Transcription Elongation	R-HSA-167169	8.876215e-02	1.052	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.876215e-02	1.052	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.876215e-02	1.052	0	0
Aggrephagy	R-HSA-9646399	8.876215e-02	1.052	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.163109e-02	1.038	0	0
Type I hemidesmosome assembly	R-HSA-446107	9.163372e-02	1.038	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	9.163372e-02	1.038	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.163372e-02	1.038	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	9.163372e-02	1.038	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	9.188345e-02	1.037	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	9.188345e-02	1.037	0	0
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	9.188345e-02	1.037	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	9.188345e-02	1.037	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	9.188345e-02	1.037	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	9.188345e-02	1.037	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.188345e-02	1.037	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	9.188345e-02	1.037	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.243531e-02	1.034	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.147760e-01	0.940	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.147760e-01	0.940	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.147760e-01	0.940	0	0
ALK mutants bind TKIs	R-HSA-9700645	1.111644e-01	0.954	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.836011e-02	1.007	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	9.836011e-02	1.007	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.136618e-01	0.944	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.094455e-01	0.961	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.141452e-01	0.943	0	0
Formation of the Early Elongation Complex	R-HSA-113418	1.141452e-01	0.943	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.141452e-01	0.943	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.154568e-01	0.938	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.057254e-01	0.976	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.057254e-01	0.976	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.057254e-01	0.976	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.130544e-01	0.947	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.794172e-02	1.009	0	0
Centrosome maturation	R-HSA-380287	1.113284e-01	0.953	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.037810e-01	0.984	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.094455e-01	0.961	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.259702e-01	0.900	1	1
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.147760e-01	0.940	0	0
Regulation of KIT signaling	R-HSA-1433559	9.836011e-02	1.007	0	0
MTOR signalling	R-HSA-165159	1.148329e-01	0.940	1	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.258822e-01	0.900	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.047277e-01	0.980	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.047277e-01	0.980	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.209399e-01	0.917	0	0
Unwinding of DNA	R-HSA-176974	1.111644e-01	0.954	0	0
Autophagy	R-HSA-9612973	1.247925e-01	0.904	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	1.111644e-01	0.954	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.111644e-01	0.954	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.029901e-01	0.987	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.111644e-01	0.954	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.227285e-01	0.911	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.148329e-01	0.940	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.113284e-01	0.953	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.111644e-01	0.954	1	1
Zygotic genome activation (ZGA)	R-HSA-9819196	1.094455e-01	0.961	0	0
HDL assembly	R-HSA-8963896	9.836011e-02	1.007	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.094455e-01	0.961	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.299370e-01	0.886	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.299370e-01	0.886	0	0
Prolonged ERK activation events	R-HSA-169893	1.299370e-01	0.886	0	0
Negative regulation of FLT3	R-HSA-9706369	1.299370e-01	0.886	0	0
Neurexins and neuroligins	R-HSA-6794361	1.307672e-01	0.884	0	0
Circadian clock	R-HSA-9909396	1.315254e-01	0.881	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.321220e-01	0.879	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.321220e-01	0.879	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.321220e-01	0.879	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.321220e-01	0.879	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.321220e-01	0.879	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.342628e-01	0.872	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.352314e-01	0.869	0	0
Generic Transcription Pathway	R-HSA-212436	1.355914e-01	0.868	1	0
FGFR2 alternative splicing	R-HSA-6803529	1.367195e-01	0.864	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.367195e-01	0.864	0	0
mTORC1-mediated signalling	R-HSA-166208	1.367195e-01	0.864	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.367195e-01	0.864	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.381797e-01	0.860	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.381797e-01	0.860	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.387568e-01	0.858	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.416402e-01	0.849	1	0
Developmental Biology	R-HSA-1266738	1.422671e-01	0.847	1	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.443014e-01	0.841	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.443014e-01	0.841	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.470208e-01	0.833	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.470208e-01	0.833	0	0
PTK6 Down-Regulation	R-HSA-8849472	1.470208e-01	0.833	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.470208e-01	0.833	0	0
IRS activation	R-HSA-74713	1.470208e-01	0.833	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.470208e-01	0.833	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.470208e-01	0.833	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.470208e-01	0.833	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.470208e-01	0.833	0	0
Hydroxycarboxylic acid-binding receptors	R-HSA-3296197	1.470208e-01	0.833	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.471114e-01	0.832	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.471114e-01	0.832	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.473469e-01	0.832	1	1
Translation initiation complex formation	R-HSA-72649	1.498461e-01	0.824	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.510132e-01	0.821	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.510132e-01	0.821	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.510132e-01	0.821	0	0
Opioid Signalling	R-HSA-111885	1.513324e-01	0.820	0	0
Interleukin receptor SHC signaling	R-HSA-912526	1.513783e-01	0.820	0	0
Syndecan interactions	R-HSA-3000170	1.513783e-01	0.820	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.753293e-01	0.756	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.753293e-01	0.756	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.511118e-01	0.600	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.511118e-01	0.600	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.511118e-01	0.600	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.511118e-01	0.600	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.511118e-01	0.600	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.511118e-01	0.600	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.511118e-01	0.600	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.511118e-01	0.600	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.511118e-01	0.600	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.808161e-01	0.743	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.808161e-01	0.743	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.808161e-01	0.743	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.199345e-01	0.495	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.199345e-01	0.495	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.199345e-01	0.495	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.199345e-01	0.495	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.199345e-01	0.495	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.156054e-01	0.666	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.156054e-01	0.666	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.156054e-01	0.666	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.543238e-01	0.812	1	1
Signaling by APC mutants	R-HSA-4839744	1.543238e-01	0.812	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.543238e-01	0.812	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.543238e-01	0.812	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.543238e-01	0.812	0	0
Activation of RAC1	R-HSA-428540	1.775860e-01	0.751	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.775860e-01	0.751	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.775860e-01	0.751	0	0
PTK6 Expression	R-HSA-8849473	2.509211e-01	0.600	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	2.509211e-01	0.600	0	0
SOS-mediated signalling	R-HSA-112412	2.509211e-01	0.600	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.824360e-01	0.417	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.824360e-01	0.417	0	0
Invadopodia formation	R-HSA-8941237	3.824360e-01	0.417	0	0
MET activates PTPN11	R-HSA-8865999	3.824360e-01	0.417	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.824360e-01	0.417	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.017281e-01	0.695	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.017281e-01	0.695	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.017281e-01	0.695	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.017281e-01	0.695	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.017281e-01	0.695	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.017281e-01	0.695	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.017281e-01	0.695	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.017281e-01	0.695	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.017281e-01	0.695	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.651055e-01	0.782	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	2.863729e-01	0.543	0	0
MET receptor recycling	R-HSA-8875656	2.863729e-01	0.543	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	2.863729e-01	0.543	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.265749e-01	0.645	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.519593e-01	0.599	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.519593e-01	0.599	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.216379e-01	0.493	0	0
ARMS-mediated activation	R-HSA-170984	3.216379e-01	0.493	0	0
WNT mediated activation of DVL	R-HSA-201688	3.216379e-01	0.493	0	0
HCN channels	R-HSA-1296061	4.391967e-01	0.357	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.391967e-01	0.357	1	1
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.391967e-01	0.357	1	1
Defective MAT1A causes MATD	R-HSA-5579024	4.391967e-01	0.357	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.391967e-01	0.357	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.391967e-01	0.357	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.231665e-01	0.651	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.231665e-01	0.651	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.777237e-01	0.556	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.781789e-01	0.749	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.564513e-01	0.448	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.564513e-01	0.448	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.157786e-01	0.666	0	0
Striated Muscle Contraction	R-HSA-390522	1.924508e-01	0.716	0	0
Phosphorylation of the APC/C	R-HSA-176412	3.037212e-01	0.518	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.507396e-01	0.601	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.298156e-01	0.482	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.298156e-01	0.482	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	3.905984e-01	0.408	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	3.905984e-01	0.408	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.702203e-01	0.769	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.687282e-01	0.571	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.687282e-01	0.571	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.558829e-01	0.449	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.558829e-01	0.449	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	3.558829e-01	0.449	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.393002e-01	0.621	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.263926e-01	0.645	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.284277e-01	0.484	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.239077e-01	0.373	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.392696e-01	0.621	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.241018e-01	0.489	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.020572e-01	0.520	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.828166e-01	0.548	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.657250e-01	0.576	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.792624e-01	0.554	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	4.074964e-01	0.390	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.074964e-01	0.390	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.074964e-01	0.390	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.562450e-01	0.341	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	4.562450e-01	0.341	0	0
Scavenging by Class F Receptors	R-HSA-3000484	4.562450e-01	0.341	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.616886e-01	0.442	0	0
Dual Incision in GG-NER	R-HSA-5696400	3.616886e-01	0.442	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.931836e-01	0.405	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.522618e-01	0.453	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	4.328514e-01	0.364	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.328514e-01	0.364	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.328514e-01	0.364	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.328514e-01	0.364	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.328514e-01	0.364	0	0
snRNP Assembly	R-HSA-191859	3.208623e-01	0.494	0	0
Metabolism of non-coding RNA	R-HSA-194441	3.208623e-01	0.494	0	0
Transcription of the HIV genome	R-HSA-167172	3.139199e-01	0.503	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.742573e-01	0.427	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.358825e-01	0.361	0	0
mRNA Capping	R-HSA-72086	4.358825e-01	0.361	0	0
Late endosomal microautophagy	R-HSA-9615710	4.358825e-01	0.361	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.358825e-01	0.361	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.030341e-01	0.395	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.030341e-01	0.395	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.199327e-01	0.377	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.367684e-01	0.360	0	0
Dual incision in TC-NER	R-HSA-6782135	4.516048e-01	0.345	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.332045e-01	0.363	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	2.481563e-01	0.605	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.368101e-01	0.360	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.644148e-01	0.578	0	0
MET promotes cell motility	R-HSA-8875878	4.368101e-01	0.360	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.402905e-01	0.468	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.231665e-01	0.651	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.561381e-01	0.341	0	0
Signaling by ERBB2	R-HSA-1227986	2.144911e-01	0.669	1	0
G0 and Early G1	R-HSA-1538133	1.643560e-01	0.784	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.863729e-01	0.543	0	0
TGFBR3 expression	R-HSA-9839394	1.825220e-01	0.739	0	0
Repression of WNT target genes	R-HSA-4641265	4.562450e-01	0.341	0	0
DNA Damage Bypass	R-HSA-73893	3.128229e-01	0.505	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.535707e-01	0.596	0	0
Frs2-mediated activation	R-HSA-170968	2.265749e-01	0.645	0	0
Interleukin-2 signaling	R-HSA-9020558	1.543238e-01	0.812	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.216379e-01	0.493	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.564513e-01	0.448	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.918025e-01	0.717	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.284277e-01	0.484	0	0
Interleukin-15 signaling	R-HSA-8983432	4.562450e-01	0.341	0	0
Signaling by PTK6	R-HSA-8848021	2.503486e-01	0.601	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.503486e-01	0.601	0	0
MHC class II antigen presentation	R-HSA-2132295	2.540159e-01	0.595	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.216379e-01	0.493	0	0
Nuclear RNA decay	R-HSA-9930044	1.781789e-01	0.749	0	0
PI3K/AKT activation	R-HSA-198203	3.564513e-01	0.448	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.428604e-01	0.465	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.536094e-01	0.451	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.536094e-01	0.451	0	0
Oncogene Induced Senescence	R-HSA-2559585	3.805405e-01	0.420	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.687282e-01	0.571	1	0
Interleukin-2 family signaling	R-HSA-451927	3.020572e-01	0.520	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.616886e-01	0.442	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.740971e-01	0.759	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.828166e-01	0.548	0	0
Regulation of gap junction activity	R-HSA-191650	4.391967e-01	0.357	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.777237e-01	0.556	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	3.564513e-01	0.448	0	0
Orc1 removal from chromatin	R-HSA-68949	2.263926e-01	0.645	0	0
NF-kB is activated and signals survival	R-HSA-209560	4.239077e-01	0.373	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.894071e-01	0.723	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.562450e-01	0.341	0	0
HSF1-dependent transactivation	R-HSA-3371571	3.433738e-01	0.464	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.993721e-01	0.399	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	3.492075e-01	0.457	1	0
Germ layer formation at gastrulation	R-HSA-9754189	4.074964e-01	0.390	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.989113e-01	0.701	0	0
HSF1 activation	R-HSA-3371511	3.993721e-01	0.399	0	0
Interleukin-1 signaling	R-HSA-9020702	2.885889e-01	0.540	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	3.433738e-01	0.464	0	0
Signaling by WNT in cancer	R-HSA-4791275	3.054605e-01	0.515	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.602391e-01	0.795	1	0
Late Phase of HIV Life Cycle	R-HSA-162599	2.870249e-01	0.542	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.808161e-01	0.743	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.519593e-01	0.599	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.777237e-01	0.556	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.435935e-01	0.613	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.564513e-01	0.448	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.851790e-01	0.732	1	1
Formation of the posterior neural plate	R-HSA-9832991	3.905984e-01	0.408	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.558829e-01	0.449	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.428604e-01	0.465	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.258658e-01	0.646	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.328514e-01	0.364	0	0
IRS-mediated signalling	R-HSA-112399	4.362141e-01	0.360	1	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.353658e-01	0.361	0	0
PCP/CE pathway	R-HSA-4086400	4.477817e-01	0.349	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.559178e-01	0.807	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	3.280437e-01	0.484	0	0
Signaling by NOTCH1	R-HSA-1980143	4.208688e-01	0.376	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	3.037212e-01	0.518	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.562450e-01	0.341	1	1
Cilium Assembly	R-HSA-5617833	2.895402e-01	0.538	0	0
HCMV Infection	R-HSA-9609646	1.859394e-01	0.731	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.354187e-01	0.474	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.808161e-01	0.743	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.982146e-01	0.703	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.648835e-01	0.783	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.693640e-01	0.570	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.716316e-01	0.430	0	0
GPER1 signaling	R-HSA-9634597	4.535130e-01	0.343	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.221149e-01	0.492	1	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.239077e-01	0.373	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.805405e-01	0.420	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.586659e-01	0.800	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.536094e-01	0.451	0	0
Metabolism of RNA	R-HSA-8953854	2.457638e-01	0.609	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.057929e-01	0.392	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.377126e-01	0.359	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.777237e-01	0.556	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.074964e-01	0.390	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	2.017281e-01	0.695	0	0
Signaling by Hedgehog	R-HSA-5358351	2.451395e-01	0.611	0	0
Polo-like kinase mediated events	R-HSA-156711	1.838364e-01	0.736	0	0
Stabilization of p53	R-HSA-69541	4.553401e-01	0.342	0	0
HIV Life Cycle	R-HSA-162587	2.519611e-01	0.599	0	0
IGF1R signaling cascade	R-HSA-2428924	3.922262e-01	0.406	1	0
C-type lectin receptors (CLRs)	R-HSA-5621481	3.766050e-01	0.424	0	0
Cellular response to chemical stress	R-HSA-9711123	3.590472e-01	0.445	1	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.753293e-01	0.756	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.511118e-01	0.600	0	0
Manipulation of host energy metabolism	R-HSA-9636667	2.511118e-01	0.600	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.199345e-01	0.495	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.199345e-01	0.495	0	0
Interleukin-33 signaling	R-HSA-9014843	3.199345e-01	0.495	0	0
C6 deamination of adenosine	R-HSA-75102	3.199345e-01	0.495	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.775860e-01	0.751	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.824360e-01	0.417	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.824360e-01	0.417	0	0
Dopamine receptors	R-HSA-390651	4.391967e-01	0.357	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.391967e-01	0.357	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.777237e-01	0.556	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.644148e-01	0.578	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.533583e-01	0.596	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.558829e-01	0.449	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.262155e-01	0.645	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.500246e-01	0.456	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.100628e-01	0.678	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.616886e-01	0.442	0	0
PI3K Cascade	R-HSA-109704	3.280437e-01	0.484	1	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.635008e-01	0.439	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.030341e-01	0.395	0	0
Signaling by MET	R-HSA-6806834	3.444273e-01	0.463	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.066184e-01	0.391	1	0
Vesicle-mediated transport	R-HSA-5653656	1.901131e-01	0.721	1	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.725131e-01	0.763	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.144911e-01	0.669	0	0
G1/S Transition	R-HSA-69206	2.809356e-01	0.551	1	0
RMTs methylate histone arginines	R-HSA-3214858	3.861020e-01	0.413	0	0
The NLRP3 inflammasome	R-HSA-844456	2.032188e-01	0.692	0	0
Protein methylation	R-HSA-8876725	2.777237e-01	0.556	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	3.993721e-01	0.399	0	0
DNA Damage Reversal	R-HSA-73942	2.777237e-01	0.556	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.569963e-01	0.447	0	0
Signaling by TGFBR3	R-HSA-9839373	2.680851e-01	0.572	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	3.564513e-01	0.448	0	0
Signal attenuation	R-HSA-74749	3.564513e-01	0.448	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.298156e-01	0.482	0	0
tRNA processing in the nucleus	R-HSA-6784531	3.635008e-01	0.439	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.454929e-01	0.462	0	0
FLT3 signaling in disease	R-HSA-9682385	3.993721e-01	0.399	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.894001e-01	0.723	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.115965e-01	0.674	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.069108e-01	0.513	1	1
DARPP-32 events	R-HSA-180024	4.358825e-01	0.361	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.891980e-01	0.723	0	0
MAP kinase activation	R-HSA-450294	3.492075e-01	0.457	0	0
Integration of energy metabolism	R-HSA-163685	4.057929e-01	0.392	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.808161e-01	0.743	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.863729e-01	0.543	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.519593e-01	0.599	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	3.216379e-01	0.493	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.924508e-01	0.716	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.277133e-01	0.485	1	1
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.492075e-01	0.457	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.255341e-01	0.647	0	0
Muscle contraction	R-HSA-397014	3.145295e-01	0.502	0	0
Smooth Muscle Contraction	R-HSA-445355	2.392696e-01	0.621	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.667964e-01	0.778	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.181418e-01	0.379	0	0
HCMV Late Events	R-HSA-9610379	2.519611e-01	0.599	0	0
Macroautophagy	R-HSA-1632852	2.699782e-01	0.569	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.428604e-01	0.465	0	0
Selective autophagy	R-HSA-9663891	2.315636e-01	0.635	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.341297e-01	0.631	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.702203e-01	0.769	0	0
Gap junction trafficking	R-HSA-190828	2.393002e-01	0.621	0	0
PI Metabolism	R-HSA-1483255	2.080326e-01	0.682	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.808161e-01	0.743	0	0
DSCAM interactions	R-HSA-376172	3.199345e-01	0.495	0	0
GP1b-IX-V activation signalling	R-HSA-430116	3.216379e-01	0.493	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.216379e-01	0.493	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.037212e-01	0.518	0	0
Synthesis of PI	R-HSA-1483226	3.905984e-01	0.408	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.558829e-01	0.449	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.054605e-01	0.515	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	3.818102e-01	0.418	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.680851e-01	0.572	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.931836e-01	0.405	1	1
Negative regulation of MET activity	R-HSA-6807004	4.328514e-01	0.364	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.343006e-01	0.630	0	0
ISG15 antiviral mechanism	R-HSA-1169408	2.829927e-01	0.548	0	0
Signaling by ALK	R-HSA-201556	2.856091e-01	0.544	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.186723e-01	0.497	0	0
Signaling by SCF-KIT	R-HSA-1433557	3.691672e-01	0.433	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.535707e-01	0.596	1	1
Protein hydroxylation	R-HSA-9629569	4.328514e-01	0.364	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.059808e-01	0.514	1	0
Elastic fibre formation	R-HSA-1566948	4.368101e-01	0.360	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.156054e-01	0.666	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.216379e-01	0.493	0	0
Nuclear import of Rev protein	R-HSA-180746	2.071391e-01	0.684	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	3.905984e-01	0.408	1	1
PECAM1 interactions	R-HSA-210990	3.905984e-01	0.408	0	0
Inflammasomes	R-HSA-622312	4.146193e-01	0.382	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.629449e-01	0.788	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	2.071391e-01	0.684	0	0
Signal transduction by L1	R-HSA-445144	2.231665e-01	0.651	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.818102e-01	0.418	0	0
Signaling by NOTCH3	R-HSA-9012852	4.052688e-01	0.392	0	0
Inositol phosphate metabolism	R-HSA-1483249	2.228534e-01	0.652	0	0
Formation of the anterior neural plate	R-HSA-9823739	2.777237e-01	0.556	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.509211e-01	0.600	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	3.824360e-01	0.417	0	0
Sodium/Proton exchangers	R-HSA-425986	2.863729e-01	0.543	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.216379e-01	0.493	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.391967e-01	0.357	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.564513e-01	0.448	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	3.020572e-01	0.520	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.020572e-01	0.520	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.186723e-01	0.497	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	4.562450e-01	0.341	0	0
IRAK1 recruits IKK complex	R-HSA-937039	4.562450e-01	0.341	0	0
NGF-stimulated transcription	R-HSA-9031628	4.535130e-01	0.343	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.764823e-01	0.424	0	0
Zinc transporters	R-HSA-435354	2.519593e-01	0.599	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.523476e-01	0.598	1	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.543238e-01	0.812	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.216379e-01	0.493	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.777237e-01	0.556	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.905984e-01	0.408	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.693640e-01	0.570	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.239077e-01	0.373	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.199327e-01	0.377	0	0
Metal ion SLC transporters	R-HSA-425410	4.535130e-01	0.343	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.064701e-01	0.514	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	1.808161e-01	0.743	0	0
STING mediated induction of host immune responses	R-HSA-1834941	4.074964e-01	0.390	0	0
TNF signaling	R-HSA-75893	1.702203e-01	0.769	0	0
Signaling by NOTCH4	R-HSA-9013694	3.938978e-01	0.405	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.199327e-01	0.377	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.355340e-01	0.361	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	4.332045e-01	0.363	0	0
Signaling by Leptin	R-HSA-2586552	3.564513e-01	0.448	0	0
Plasma lipoprotein assembly	R-HSA-8963898	3.284277e-01	0.484	0	0
Activation of the pre-replicative complex	R-HSA-68962	4.569212e-01	0.340	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.569212e-01	0.340	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.569212e-01	0.340	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.569212e-01	0.340	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.577961e-01	0.339	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.577961e-01	0.339	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.577961e-01	0.339	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.681604e-01	0.330	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.701400e-01	0.328	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.736970e-01	0.324	0	0
Attenuation phase	R-HSA-3371568	4.736970e-01	0.324	0	0
Signaling by FGFR2	R-HSA-5654738	4.745175e-01	0.324	0	0
Synthesis of DNA	R-HSA-69239	4.767647e-01	0.322	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.776882e-01	0.321	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.781227e-01	0.320	0	0
Interleukin-17 signaling	R-HSA-448424	4.781227e-01	0.320	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.822614e-01	0.317	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.822614e-01	0.317	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.875076e-01	0.312	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.875076e-01	0.312	0	0
Processing of SMDT1	R-HSA-8949664	4.875076e-01	0.312	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.875076e-01	0.312	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.875076e-01	0.312	1	1
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.875076e-01	0.312	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.875076e-01	0.312	0	0
Stimuli-sensing channels	R-HSA-2672351	4.881783e-01	0.311	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	4.907436e-01	0.309	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.907436e-01	0.309	0	0
PTK6 Activates STAT3	R-HSA-8849474	4.907436e-01	0.309	0	0
Reelin signalling pathway	R-HSA-8866376	4.907436e-01	0.309	0	0
Interleukin-36 pathway	R-HSA-9014826	4.907436e-01	0.309	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.907436e-01	0.309	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.907436e-01	0.309	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.907436e-01	0.309	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.907436e-01	0.309	0	0
Hedgehog 'on' state	R-HSA-5632684	4.922100e-01	0.308	0	0
DNA strand elongation	R-HSA-69190	4.981406e-01	0.303	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	5.061882e-01	0.296	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.061882e-01	0.296	0	0
LDL clearance	R-HSA-8964038	5.061882e-01	0.296	0	0
IRE1alpha activates chaperones	R-HSA-381070	5.087198e-01	0.294	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.097660e-01	0.293	0	0
TCR signaling	R-HSA-202403	5.108372e-01	0.292	0	0
HIV Infection	R-HSA-162906	5.118361e-01	0.291	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.126832e-01	0.290	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.176198e-01	0.286	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.176198e-01	0.286	0	0
Hydrolysis of LPC	R-HSA-1483115	5.176198e-01	0.286	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.176198e-01	0.286	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.182404e-01	0.285	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.182404e-01	0.285	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.182404e-01	0.285	1	1
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.190718e-01	0.285	0	0
Ca2+ pathway	R-HSA-4086398	5.200440e-01	0.284	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.269189e-01	0.278	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.274015e-01	0.278	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.295263e-01	0.276	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.295263e-01	0.276	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.295263e-01	0.276	0	0
Growth hormone receptor signaling	R-HSA-982772	5.295263e-01	0.276	0	0
Signaling by ERBB4	R-HSA-1236394	5.337623e-01	0.273	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.375552e-01	0.270	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.375552e-01	0.270	0	0
PKB-mediated events	R-HSA-109703	5.375552e-01	0.270	1	0
Cam-PDE 1 activation	R-HSA-111957	5.375552e-01	0.270	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.375552e-01	0.270	0	0
PDE3B signalling	R-HSA-165160	5.375552e-01	0.270	1	1
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.375552e-01	0.270	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.375552e-01	0.270	0	0
Terminal pathway of complement	R-HSA-166665	5.375552e-01	0.270	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.375552e-01	0.270	0	0
NGF-independant TRKA activation	R-HSA-187024	5.375552e-01	0.270	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.375552e-01	0.270	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.375552e-01	0.270	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	5.375552e-01	0.270	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.375552e-01	0.270	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.375552e-01	0.270	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.375552e-01	0.270	0	0
Resolution of D-Loop Structures	R-HSA-5693537	5.379533e-01	0.269	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.379533e-01	0.269	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	5.379533e-01	0.269	0	0
PTEN Regulation	R-HSA-6807070	5.384642e-01	0.269	1	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.385983e-01	0.269	0	0
Insulin receptor signalling cascade	R-HSA-74751	5.415264e-01	0.266	1	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.465291e-01	0.262	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.465291e-01	0.262	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.465291e-01	0.262	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.465291e-01	0.262	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	5.465291e-01	0.262	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.465291e-01	0.262	0	0
p75NTR signals via NF-kB	R-HSA-193639	5.465291e-01	0.262	0	0
Biotin transport and metabolism	R-HSA-196780	5.465291e-01	0.262	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.465291e-01	0.262	0	0
Adaptive Immune System	R-HSA-1280218	5.485132e-01	0.261	1	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.506859e-01	0.259	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.522341e-01	0.258	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	5.522341e-01	0.258	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	5.522341e-01	0.258	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	5.522341e-01	0.258	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.522341e-01	0.258	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.525900e-01	0.258	0	0
Cellular response to hypoxia	R-HSA-1234174	5.559447e-01	0.255	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.572497e-01	0.254	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.572497e-01	0.254	0	0
Signal amplification	R-HSA-392518	5.572497e-01	0.254	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.572497e-01	0.254	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.572497e-01	0.254	0	0
Cyclin D associated events in G1	R-HSA-69231	5.618502e-01	0.250	0	0
G1 Phase	R-HSA-69236	5.618502e-01	0.250	0	0
Nucleotide Excision Repair	R-HSA-5696398	5.732041e-01	0.242	0	0
Translation of Structural Proteins	R-HSA-9694635	5.739682e-01	0.241	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.742022e-01	0.241	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.742022e-01	0.241	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.742022e-01	0.241	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	5.742022e-01	0.241	0	0
Differentiation of T cells	R-HSA-9945266	5.742022e-01	0.241	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.742022e-01	0.241	0	0
Regulation of BACH1 activity	R-HSA-9708530	5.742022e-01	0.241	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.742022e-01	0.241	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	5.742776e-01	0.241	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.742776e-01	0.241	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.742776e-01	0.241	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	5.742776e-01	0.241	0	0
Long-term potentiation	R-HSA-9620244	5.742776e-01	0.241	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.742776e-01	0.241	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.742776e-01	0.241	0	0
Signalling to ERKs	R-HSA-187687	5.761036e-01	0.239	0	0
PERK regulates gene expression	R-HSA-381042	5.761036e-01	0.239	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.785817e-01	0.238	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.785817e-01	0.238	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.800663e-01	0.237	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.800663e-01	0.237	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.800663e-01	0.237	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.800663e-01	0.237	0	0
STAT5 Activation	R-HSA-9645135	5.800663e-01	0.237	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.800663e-01	0.237	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.800663e-01	0.237	0	0
Hydrolysis of LPE	R-HSA-1483152	5.800663e-01	0.237	0	0
Chylomicron clearance	R-HSA-8964026	5.800663e-01	0.237	0	0
Neurofascin interactions	R-HSA-447043	5.800663e-01	0.237	0	0
COPI-mediated anterograde transport	R-HSA-6807878	5.810498e-01	0.236	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.813219e-01	0.236	0	0
Ion homeostasis	R-HSA-5578775	5.813219e-01	0.236	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.813219e-01	0.236	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.949669e-01	0.226	0	0
Diseases of DNA repair	R-HSA-9675135	5.949669e-01	0.226	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	5.956301e-01	0.225	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.956301e-01	0.225	0	0
Myogenesis	R-HSA-525793	5.956301e-01	0.225	0	0
Metalloprotease DUBs	R-HSA-5689901	5.956301e-01	0.225	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.956301e-01	0.225	0	0
TRP channels	R-HSA-3295583	5.956301e-01	0.225	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.956301e-01	0.225	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.979309e-01	0.223	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.998691e-01	0.222	0	0
Sensory processing of sound	R-HSA-9659379	5.998691e-01	0.222	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.006221e-01	0.221	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.006221e-01	0.221	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.006221e-01	0.221	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.006221e-01	0.221	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.006221e-01	0.221	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.006221e-01	0.221	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	6.018192e-01	0.221	1	0
Signaling by FGFR	R-HSA-190236	6.041012e-01	0.219	0	0
Degradation of AXIN	R-HSA-4641257	6.123996e-01	0.213	0	0
Degradation of DVL	R-HSA-4641258	6.123996e-01	0.213	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.123996e-01	0.213	0	0
PKR-mediated signaling	R-HSA-9833482	6.125191e-01	0.213	0	0
Downstream TCR signaling	R-HSA-202424	6.138620e-01	0.212	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	6.162716e-01	0.210	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.186718e-01	0.209	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.186718e-01	0.209	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.186718e-01	0.209	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.186718e-01	0.209	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.186718e-01	0.209	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.186718e-01	0.209	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.186718e-01	0.209	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.186718e-01	0.209	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.186718e-01	0.209	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	6.186718e-01	0.209	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.186718e-01	0.209	0	0
Ca2+ activated K+ channels	R-HSA-1296052	6.186718e-01	0.209	0	0
VLDL clearance	R-HSA-8964046	6.186718e-01	0.209	0	0
Activation of TRKA receptors	R-HSA-187015	6.186718e-01	0.209	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.186718e-01	0.209	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.186718e-01	0.209	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.257853e-01	0.204	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.257853e-01	0.204	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.257853e-01	0.204	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.257853e-01	0.204	0	0
Influenza Infection	R-HSA-168255	6.298896e-01	0.201	0	0
Signaling by NTRKs	R-HSA-166520	6.333447e-01	0.198	0	0
Telomere Extension By Telomerase	R-HSA-171319	6.361878e-01	0.196	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.361878e-01	0.196	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.361878e-01	0.196	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	6.374836e-01	0.196	1	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.392048e-01	0.194	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.392048e-01	0.194	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.392048e-01	0.194	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.392048e-01	0.194	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.392048e-01	0.194	0	0
Degradation of CDH1	R-HSA-9766229	6.419027e-01	0.193	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.430559e-01	0.192	0	0
Signaling by TGFB family members	R-HSA-9006936	6.435788e-01	0.191	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.467069e-01	0.189	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.467069e-01	0.189	0	0
Cytoprotection by HMOX1	R-HSA-9707564	6.491711e-01	0.188	0	0
GAB1 signalosome	R-HSA-180292	6.496995e-01	0.187	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	6.496995e-01	0.187	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.496995e-01	0.187	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.496995e-01	0.187	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.537303e-01	0.185	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.537303e-01	0.185	0	0
phospho-PLA2 pathway	R-HSA-111995	6.537303e-01	0.185	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.537303e-01	0.185	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.537303e-01	0.185	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.537303e-01	0.185	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.537303e-01	0.185	0	0
Interleukin-9 signaling	R-HSA-8985947	6.537303e-01	0.185	0	0
Adrenoceptors	R-HSA-390696	6.537303e-01	0.185	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.537303e-01	0.185	0	0
Co-stimulation by ICOS	R-HSA-9927354	6.537303e-01	0.185	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.537303e-01	0.185	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.537303e-01	0.185	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	6.553698e-01	0.184	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	6.553698e-01	0.184	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.553698e-01	0.184	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	6.553698e-01	0.184	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.609334e-01	0.180	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.630869e-01	0.178	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.630869e-01	0.178	0	0
Diseases of Immune System	R-HSA-5260271	6.630869e-01	0.178	0	0
Glycogen metabolism	R-HSA-8982491	6.630869e-01	0.178	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.712362e-01	0.173	0	0
Translesion Synthesis by POLH	R-HSA-110320	6.723817e-01	0.172	0	0
Regulation of signaling by CBL	R-HSA-912631	6.723817e-01	0.172	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.723817e-01	0.172	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.723817e-01	0.172	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	6.723817e-01	0.172	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.738135e-01	0.171	0	0
Hemostasis	R-HSA-109582	6.780485e-01	0.169	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.788654e-01	0.168	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.789419e-01	0.168	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.789419e-01	0.168	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	6.789419e-01	0.168	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.789419e-01	0.168	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.789419e-01	0.168	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.852935e-01	0.164	0	0
SARS-CoV-1 Infection	R-HSA-9678108	6.853845e-01	0.164	0	0
Interleukin-21 signaling	R-HSA-9020958	6.855675e-01	0.164	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.855675e-01	0.164	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.855675e-01	0.164	0	0
Calcineurin activates NFAT	R-HSA-2025928	6.855675e-01	0.164	0	0
Lipophagy	R-HSA-9613354	6.855675e-01	0.164	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.855675e-01	0.164	0	0
p75NTR regulates axonogenesis	R-HSA-193697	6.855675e-01	0.164	0	0
mRNA Editing	R-HSA-75072	6.855675e-01	0.164	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.855675e-01	0.164	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.855675e-01	0.164	0	0
Interleukin-1 processing	R-HSA-448706	6.855675e-01	0.164	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.855675e-01	0.164	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.855675e-01	0.164	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.871963e-01	0.163	0	0
SARS-CoV-2 Infection	R-HSA-9694516	6.914095e-01	0.160	1	0
EGFR downregulation	R-HSA-182971	6.915192e-01	0.160	0	0
Budding and maturation of HIV virion	R-HSA-162588	6.915192e-01	0.160	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.915192e-01	0.160	0	0
Ion transport by P-type ATPases	R-HSA-936837	6.920405e-01	0.160	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	6.935519e-01	0.159	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.938563e-01	0.159	0	0
Nephrin family interactions	R-HSA-373753	6.938563e-01	0.159	0	0
Acyl chain remodelling of PI	R-HSA-1482922	6.938563e-01	0.159	0	0
Signaling by NODAL	R-HSA-1181150	6.938563e-01	0.159	0	0
Formation of definitive endoderm	R-HSA-9823730	6.938563e-01	0.159	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.942682e-01	0.158	0	0
HIV Transcription Initiation	R-HSA-167161	6.942682e-01	0.158	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.942682e-01	0.158	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	6.942682e-01	0.158	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	6.942682e-01	0.158	0	0
Translation of Structural Proteins	R-HSA-9683701	6.942682e-01	0.158	0	0
UCH proteinases	R-HSA-5689603	6.988492e-01	0.156	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.989387e-01	0.156	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	6.994214e-01	0.155	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	7.044136e-01	0.152	0	0
Chaperonin-mediated protein folding	R-HSA-390466	7.055717e-01	0.151	0	0
Ion channel transport	R-HSA-983712	7.080201e-01	0.150	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.084907e-01	0.150	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.084907e-01	0.150	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.141534e-01	0.146	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.141534e-01	0.146	0	0
Basigin interactions	R-HSA-210991	7.141534e-01	0.146	0	0
2-LTR circle formation	R-HSA-164843	7.144792e-01	0.146	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.144792e-01	0.146	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.144792e-01	0.146	0	0
Regulation of the apoptosome activity	R-HSA-9627069	7.144792e-01	0.146	0	0
Formation of apoptosome	R-HSA-111458	7.144792e-01	0.146	0	0
Regulation of CDH11 function	R-HSA-9762292	7.144792e-01	0.146	0	0
Binding and entry of HIV virion	R-HSA-173107	7.144792e-01	0.146	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.144792e-01	0.146	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.144792e-01	0.146	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.144792e-01	0.146	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.144792e-01	0.146	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.144792e-01	0.146	0	0
Josephin domain DUBs	R-HSA-5689877	7.144792e-01	0.146	0	0
Mitochondrial biogenesis	R-HSA-1592230	7.157979e-01	0.145	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.185256e-01	0.144	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.185256e-01	0.144	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.219862e-01	0.141	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.219862e-01	0.141	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.219862e-01	0.141	0	0
Regulation of insulin secretion	R-HSA-422356	7.219862e-01	0.141	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.233317e-01	0.141	0	0
Signaling by FGFR4	R-HSA-5654743	7.233317e-01	0.141	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.233317e-01	0.141	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.247353e-01	0.140	1	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.247353e-01	0.140	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.249843e-01	0.140	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.333082e-01	0.135	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.333082e-01	0.135	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.333082e-01	0.135	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.333082e-01	0.135	0	0
Gastrulation	R-HSA-9758941	7.344730e-01	0.134	0	0
Proteasome assembly	R-HSA-9907900	7.370723e-01	0.132	0	0
Signaling by EGFR	R-HSA-177929	7.373839e-01	0.132	0	0
Signaling by FGFR1	R-HSA-5654736	7.373839e-01	0.132	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.394818e-01	0.131	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.402630e-01	0.131	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.402630e-01	0.131	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.407340e-01	0.130	0	0
LGI-ADAM interactions	R-HSA-5682910	7.407340e-01	0.130	0	0
FGFR2b ligand binding and activation	R-HSA-190377	7.407340e-01	0.130	0	0
vRNA Synthesis	R-HSA-192814	7.407340e-01	0.130	0	0
vRNP Assembly	R-HSA-192905	7.407340e-01	0.130	0	0
Bicarbonate transporters	R-HSA-425381	7.407340e-01	0.130	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.407340e-01	0.130	0	0
Transport of RCbl within the body	R-HSA-9758890	7.407340e-01	0.130	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.407340e-01	0.130	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.407340e-01	0.130	0	0
Suppression of apoptosis	R-HSA-9635465	7.407340e-01	0.130	0	0
Prostanoid ligand receptors	R-HSA-391908	7.407340e-01	0.130	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.502907e-01	0.125	0	0
Signaling by FGFR3	R-HSA-5654741	7.502907e-01	0.125	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.502907e-01	0.125	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.502907e-01	0.125	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	7.502907e-01	0.125	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.513589e-01	0.124	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.513589e-01	0.124	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.513589e-01	0.124	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.513589e-01	0.124	0	0
Adipogenesis	R-HSA-9843745	7.550413e-01	0.122	0	0
Signaling by NOTCH2	R-HSA-1980145	7.550863e-01	0.122	0	0
RAF activation	R-HSA-5673000	7.550863e-01	0.122	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.550863e-01	0.122	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.550863e-01	0.122	0	0
Gap junction assembly	R-HSA-190861	7.550863e-01	0.122	0	0
Mitophagy	R-HSA-5205647	7.550863e-01	0.122	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	7.550863e-01	0.122	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.609442e-01	0.119	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	7.620621e-01	0.118	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.629928e-01	0.117	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.629928e-01	0.117	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.645760e-01	0.117	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.645760e-01	0.117	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.645760e-01	0.117	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.645760e-01	0.117	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.645760e-01	0.117	0	0
Sodium/Calcium exchangers	R-HSA-425561	7.645760e-01	0.117	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.645760e-01	0.117	0	0
Integration of provirus	R-HSA-162592	7.645760e-01	0.117	0	0
Eukaryotic Translation Elongation	R-HSA-156842	7.649931e-01	0.116	0	0
Protein folding	R-HSA-391251	7.649931e-01	0.116	0	0
Signaling by Insulin receptor	R-HSA-74752	7.649931e-01	0.116	1	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.649931e-01	0.116	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.649931e-01	0.116	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.683466e-01	0.114	0	0
Carnitine shuttle	R-HSA-200425	7.683466e-01	0.114	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.692199e-01	0.114	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.692199e-01	0.114	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.692199e-01	0.114	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.692199e-01	0.114	0	0
Regulation of Apoptosis	R-HSA-169911	7.692199e-01	0.114	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.721110e-01	0.112	0	0
Host Interactions of HIV factors	R-HSA-162909	7.743511e-01	0.111	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.751861e-01	0.111	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.814565e-01	0.107	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.814565e-01	0.107	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.826801e-01	0.106	0	0
RUNX2 regulates bone development	R-HSA-8941326	7.826801e-01	0.106	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.826801e-01	0.106	0	0
G1/S-Specific Transcription	R-HSA-69205	7.826801e-01	0.106	0	0
Triglyceride catabolism	R-HSA-163560	7.826801e-01	0.106	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.828748e-01	0.106	0	0
Leading Strand Synthesis	R-HSA-69109	7.862268e-01	0.104	0	0
Polymerase switching	R-HSA-69091	7.862268e-01	0.104	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	7.862268e-01	0.104	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.862268e-01	0.104	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.862268e-01	0.104	0	0
VLDLR internalisation and degradation	R-HSA-8866427	7.862268e-01	0.104	0	0
Signaling by LTK	R-HSA-9842663	7.862268e-01	0.104	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.862268e-01	0.104	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.862268e-01	0.104	0	0
Regulation of IFNG signaling	R-HSA-877312	7.862268e-01	0.104	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.862268e-01	0.104	0	0
MET activates RAS signaling	R-HSA-8851805	7.862268e-01	0.104	0	0
p75NTR recruits signalling complexes	R-HSA-209543	7.862268e-01	0.104	0	0
OAS antiviral response	R-HSA-8983711	7.862268e-01	0.104	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.868432e-01	0.104	0	0
Gluconeogenesis	R-HSA-70263	7.868788e-01	0.104	0	0
Co-stimulation by CD28	R-HSA-389356	7.868788e-01	0.104	1	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.926175e-01	0.101	0	0
Aquaporin-mediated transport	R-HSA-445717	7.932409e-01	0.101	0	0
Formation of paraxial mesoderm	R-HSA-9793380	7.932409e-01	0.101	0	0
Ovarian tumor domain proteases	R-HSA-5689896	7.954847e-01	0.099	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.993053e-01	0.097	0	0
Tight junction interactions	R-HSA-420029	7.993053e-01	0.097	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.993053e-01	0.097	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	7.995239e-01	0.097	0	0
Cap-dependent Translation Initiation	R-HSA-72737	8.018898e-01	0.096	0	0
Eukaryotic Translation Initiation	R-HSA-72613	8.018898e-01	0.096	0	0
Adenylate cyclase activating pathway	R-HSA-170660	8.058876e-01	0.094	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.058876e-01	0.094	0	0
Formation of axial mesoderm	R-HSA-9796292	8.058876e-01	0.094	0	0
FGFR1c ligand binding and activation	R-HSA-190373	8.058876e-01	0.094	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.058876e-01	0.094	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.058876e-01	0.094	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.058876e-01	0.094	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.058876e-01	0.094	0	0
Chylomicron remodeling	R-HSA-8963901	8.058876e-01	0.094	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.058876e-01	0.094	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.058876e-01	0.094	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.058876e-01	0.094	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	8.058876e-01	0.094	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.058876e-01	0.094	0	0
Signaling by Interleukins	R-HSA-449147	8.079080e-01	0.093	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.133648e-01	0.090	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.133648e-01	0.090	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.133648e-01	0.090	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.154013e-01	0.089	0	0
Interleukin-12 signaling	R-HSA-9020591	8.181048e-01	0.087	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	8.190544e-01	0.087	0	0
Plasma lipoprotein clearance	R-HSA-8964043	8.192040e-01	0.087	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.192040e-01	0.087	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.192040e-01	0.087	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.225588e-01	0.085	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.229648e-01	0.085	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.229648e-01	0.085	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.237413e-01	0.084	0	0
Retrograde neurotrophin signalling	R-HSA-177504	8.237413e-01	0.084	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.237413e-01	0.084	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.237413e-01	0.084	0	0
cGMP effects	R-HSA-418457	8.237413e-01	0.084	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.237413e-01	0.084	0	0
Physiological factors	R-HSA-5578768	8.237413e-01	0.084	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.237413e-01	0.084	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.237413e-01	0.084	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.237413e-01	0.084	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.265370e-01	0.083	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.265370e-01	0.083	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.265370e-01	0.083	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.265370e-01	0.083	0	0
Insulin processing	R-HSA-264876	8.265370e-01	0.083	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	8.288494e-01	0.082	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.295019e-01	0.081	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	8.295019e-01	0.081	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.301593e-01	0.081	0	0
Generation of second messenger molecules	R-HSA-202433	8.301593e-01	0.081	0	0
ER-Phagosome pathway	R-HSA-1236974	8.316395e-01	0.080	0	0
Interleukin-1 family signaling	R-HSA-446652	8.324871e-01	0.080	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.324871e-01	0.080	0	0
Cardiac conduction	R-HSA-5576891	8.363809e-01	0.078	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.381994e-01	0.077	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.381994e-01	0.077	1	1
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.388661e-01	0.076	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	8.388661e-01	0.076	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.399538e-01	0.076	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.399538e-01	0.076	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.399538e-01	0.076	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.399538e-01	0.076	1	1
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.399538e-01	0.076	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.399538e-01	0.076	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.399538e-01	0.076	0	0
Translesion synthesis by REV1	R-HSA-110312	8.399538e-01	0.076	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.399538e-01	0.076	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.399538e-01	0.076	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.399538e-01	0.076	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.399538e-01	0.076	0	0
Spry regulation of FGF signaling	R-HSA-1295596	8.399538e-01	0.076	0	0
Maturation of spike protein	R-HSA-9694548	8.405395e-01	0.075	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.422913e-01	0.075	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.422913e-01	0.075	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.427556e-01	0.074	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.427556e-01	0.074	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.471174e-01	0.072	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.482095e-01	0.071	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.490723e-01	0.071	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.503662e-01	0.070	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	8.503662e-01	0.070	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.503959e-01	0.070	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.503959e-01	0.070	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.503959e-01	0.070	0	0
Platelet calcium homeostasis	R-HSA-418360	8.503959e-01	0.070	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.530187e-01	0.069	0	0
Translesion synthesis by POLI	R-HSA-5656121	8.546759e-01	0.068	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.546759e-01	0.068	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.546759e-01	0.068	0	0
Killing mechanisms	R-HSA-9664420	8.546759e-01	0.068	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	8.546759e-01	0.068	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.546759e-01	0.068	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	8.546759e-01	0.068	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.546759e-01	0.068	0	0
Attachment and Entry	R-HSA-9678110	8.546759e-01	0.068	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.584262e-01	0.066	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.595061e-01	0.066	0	0
Activation of BH3-only proteins	R-HSA-114452	8.611689e-01	0.065	1	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.611689e-01	0.065	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.627073e-01	0.064	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.637101e-01	0.064	0	0
SARS-CoV Infections	R-HSA-9679506	8.644875e-01	0.063	1	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.680446e-01	0.061	0	0
Translesion synthesis by POLK	R-HSA-5655862	8.680446e-01	0.061	0	0
Fibronectin matrix formation	R-HSA-1566977	8.680446e-01	0.061	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.680446e-01	0.061	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.680446e-01	0.061	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	8.693923e-01	0.061	0	0
Developmental Cell Lineages	R-HSA-9734767	8.698655e-01	0.061	0	0
Downstream signal transduction	R-HSA-186763	8.712268e-01	0.060	0	0
Trafficking of AMPA receptors	R-HSA-399719	8.712268e-01	0.060	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.712268e-01	0.060	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	8.712268e-01	0.060	0	0
Neuronal System	R-HSA-112316	8.721019e-01	0.059	0	0
Platelet degranulation	R-HSA-114608	8.759705e-01	0.058	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.766445e-01	0.057	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.780451e-01	0.056	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.801842e-01	0.055	0	0
Glycogen storage diseases	R-HSA-3229121	8.801842e-01	0.055	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.801842e-01	0.055	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.801842e-01	0.055	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.801842e-01	0.055	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.801842e-01	0.055	0	0
Choline catabolism	R-HSA-6798163	8.801842e-01	0.055	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	8.801842e-01	0.055	0	0
Somitogenesis	R-HSA-9824272	8.845674e-01	0.053	0	0
Extension of Telomeres	R-HSA-180786	8.856941e-01	0.053	0	0
Triglyceride metabolism	R-HSA-8979227	8.856941e-01	0.053	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.869798e-01	0.052	0	0
Neddylation	R-HSA-8951664	8.880078e-01	0.052	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	8.889898e-01	0.051	1	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.889917e-01	0.051	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.893574e-01	0.051	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.893574e-01	0.051	0	0
Cardiogenesis	R-HSA-9733709	8.893574e-01	0.051	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.893574e-01	0.051	0	0
Antigen processing-Cross presentation	R-HSA-1236975	8.906132e-01	0.050	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.912077e-01	0.050	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.912077e-01	0.050	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.912077e-01	0.050	0	0
Activated point mutants of FGFR2	R-HSA-2033519	8.912077e-01	0.050	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.912077e-01	0.050	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.912077e-01	0.050	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.912077e-01	0.050	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.912077e-01	0.050	0	0
Mismatch Repair	R-HSA-5358508	8.912077e-01	0.050	0	0
Platelet sensitization by LDL	R-HSA-432142	8.912077e-01	0.050	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	8.912077e-01	0.050	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.933599e-01	0.049	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.975065e-01	0.047	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.975065e-01	0.047	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.975065e-01	0.047	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.989026e-01	0.046	0	0
Interleukin-12 family signaling	R-HSA-447115	8.994890e-01	0.046	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.012175e-01	0.045	0	0
Specification of the neural plate border	R-HSA-9834899	9.012175e-01	0.045	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	9.012175e-01	0.045	0	0
PPARA activates gene expression	R-HSA-1989781	9.042615e-01	0.044	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.045187e-01	0.044	0	0
Peptide chain elongation	R-HSA-156902	9.045880e-01	0.044	0	0
eNOS activation	R-HSA-203615	9.050935e-01	0.043	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.103069e-01	0.041	0	0
Glycogen synthesis	R-HSA-3322077	9.103069e-01	0.041	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.103069e-01	0.041	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.103069e-01	0.041	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.103069e-01	0.041	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.114338e-01	0.040	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.121526e-01	0.040	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.151758e-01	0.038	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.185604e-01	0.037	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.185604e-01	0.037	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.185604e-01	0.037	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.185604e-01	0.037	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.185604e-01	0.037	0	0
Lagging Strand Synthesis	R-HSA-69186	9.185604e-01	0.037	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.185604e-01	0.037	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.185604e-01	0.037	0	0
Interferon Signaling	R-HSA-913531	9.186001e-01	0.037	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.187168e-01	0.037	0	0
Glycosphingolipid transport	R-HSA-9845576	9.187168e-01	0.037	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.248174e-01	0.034	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.248174e-01	0.034	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.250056e-01	0.034	1	1
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.254770e-01	0.034	0	0
Leishmania infection	R-HSA-9658195	9.254833e-01	0.034	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.254833e-01	0.034	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.258421e-01	0.033	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.260549e-01	0.033	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.260549e-01	0.033	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.260549e-01	0.033	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.260549e-01	0.033	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.260549e-01	0.033	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.260549e-01	0.033	0	0
Attachment and Entry	R-HSA-9694614	9.260549e-01	0.033	0	0
Neutrophil degranulation	R-HSA-6798695	9.277959e-01	0.033	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.279700e-01	0.032	0	0
Ribosome-associated quality control	R-HSA-9948299	9.290898e-01	0.032	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.299370e-01	0.032	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.304840e-01	0.031	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.304840e-01	0.031	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.328601e-01	0.030	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	9.328601e-01	0.030	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.328601e-01	0.030	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.328601e-01	0.030	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.328601e-01	0.030	0	0
Collagen formation	R-HSA-1474290	9.344037e-01	0.029	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.390394e-01	0.027	1	1
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.390394e-01	0.027	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.390394e-01	0.027	0	0
Biosynthesis of maresins	R-HSA-9018682	9.390394e-01	0.027	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.390394e-01	0.027	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.390394e-01	0.027	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.390394e-01	0.027	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.406266e-01	0.027	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.406266e-01	0.027	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.412476e-01	0.026	0	0
G alpha (z) signalling events	R-HSA-418597	9.415026e-01	0.026	0	0
CYP2E1 reactions	R-HSA-211999	9.446503e-01	0.025	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.446503e-01	0.025	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.446503e-01	0.025	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.446503e-01	0.025	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.446503e-01	0.025	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.454623e-01	0.024	1	0
Viral Infection Pathways	R-HSA-9824446	9.469754e-01	0.024	1	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.485729e-01	0.023	0	0
Intra-Golgi traffic	R-HSA-6811438	9.493522e-01	0.023	0	0
Hyaluronan degradation	R-HSA-2160916	9.497450e-01	0.022	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.497450e-01	0.022	0	0
Laminin interactions	R-HSA-3000157	9.497450e-01	0.022	0	0
Formation of the nephric duct	R-HSA-9830364	9.497450e-01	0.022	0	0
Cellular response to starvation	R-HSA-9711097	9.509021e-01	0.022	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.526448e-01	0.021	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.532422e-01	0.021	0	0
G alpha (s) signalling events	R-HSA-418555	9.532510e-01	0.021	0	0
Phospholipid metabolism	R-HSA-1483257	9.536554e-01	0.021	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.543711e-01	0.020	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.543711e-01	0.020	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.543711e-01	0.020	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.543711e-01	0.020	0	0
Formation of the cornified envelope	R-HSA-6809371	9.545202e-01	0.020	0	0
Regulation of beta-cell development	R-HSA-186712	9.558951e-01	0.020	1	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.568455e-01	0.019	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.568455e-01	0.019	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.574491e-01	0.019	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.585716e-01	0.018	0	0
Triglyceride biosynthesis	R-HSA-75109	9.585716e-01	0.018	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.585716e-01	0.018	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.585716e-01	0.018	0	0
Metabolism of polyamines	R-HSA-351202	9.589356e-01	0.018	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.591805e-01	0.018	0	0
DAP12 interactions	R-HSA-2172127	9.601820e-01	0.018	0	0
Amine ligand-binding receptors	R-HSA-375280	9.601820e-01	0.018	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.610780e-01	0.017	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.623856e-01	0.017	0	0
Insulin receptor recycling	R-HSA-77387	9.623856e-01	0.017	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.623856e-01	0.017	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.623856e-01	0.017	0	0
Pyroptosis	R-HSA-5620971	9.623856e-01	0.017	0	0
Integrin cell surface interactions	R-HSA-216083	9.655122e-01	0.015	0	0
ABC transporter disorders	R-HSA-5619084	9.655122e-01	0.015	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.656696e-01	0.015	0	0
Leishmania phagocytosis	R-HSA-9664417	9.656696e-01	0.015	0	0
Parasite infection	R-HSA-9664407	9.656696e-01	0.015	0	0
Regulation of gene expression in beta cells	R-HSA-210745	9.658487e-01	0.015	1	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.658487e-01	0.015	0	0
RSV-host interactions	R-HSA-9833110	9.667744e-01	0.015	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.669179e-01	0.015	0	0
Synthesis of PC	R-HSA-1483191	9.687702e-01	0.014	0	0
DAP12 signaling	R-HSA-2424491	9.689932e-01	0.014	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.689932e-01	0.014	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.689932e-01	0.014	0	0
Neurotransmitter clearance	R-HSA-112311	9.689932e-01	0.014	0	0
Intraflagellar transport	R-HSA-5620924	9.712136e-01	0.013	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.718483e-01	0.012	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.718483e-01	0.012	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.732853e-01	0.012	0	0
tRNA processing	R-HSA-72306	9.733699e-01	0.012	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.734189e-01	0.012	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.734721e-01	0.012	0	0
Interferon gamma signaling	R-HSA-877300	9.752460e-01	0.011	0	0
Nicotinate metabolism	R-HSA-196807	9.753023e-01	0.011	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.753413e-01	0.011	0	0
Potassium Channels	R-HSA-1296071	9.764637e-01	0.010	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.767944e-01	0.010	0	0
Regulation of necroptotic cell death	R-HSA-5675482	9.767944e-01	0.010	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.789315e-01	0.009	0	0
Heme degradation	R-HSA-189483	9.789315e-01	0.009	0	0
Hyaluronan metabolism	R-HSA-2142845	9.808720e-01	0.008	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.808720e-01	0.008	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.808720e-01	0.008	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.812403e-01	0.008	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.815844e-01	0.008	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.817901e-01	0.008	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.826338e-01	0.008	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.826338e-01	0.008	0	0
SLC transporter disorders	R-HSA-5619102	9.836013e-01	0.007	0	0
Paracetamol ADME	R-HSA-9753281	9.838256e-01	0.007	0	0
RNA Polymerase III Transcription	R-HSA-74158	9.842334e-01	0.007	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.842334e-01	0.007	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.842334e-01	0.007	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.853405e-01	0.006	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.856858e-01	0.006	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.856858e-01	0.006	0	0
Lysine catabolism	R-HSA-71064	9.856858e-01	0.006	0	0
Metabolism of folate and pterines	R-HSA-196757	9.856858e-01	0.006	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.864064e-01	0.006	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.867482e-01	0.006	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.870045e-01	0.006	0	0
Pentose phosphate pathway	R-HSA-71336	9.882017e-01	0.005	0	0
Peroxisomal protein import	R-HSA-9033241	9.884154e-01	0.005	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.884154e-01	0.005	0	0
Platelet homeostasis	R-HSA-418346	9.884901e-01	0.005	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.891756e-01	0.005	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.892306e-01	0.005	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.892738e-01	0.005	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.892888e-01	0.005	0	0
RAB geranylgeranylation	R-HSA-8873719	9.893475e-01	0.005	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.893582e-01	0.005	0	0
Signaling by PDGF	R-HSA-186797	9.909973e-01	0.004	0	0
Mitochondrial protein import	R-HSA-1268020	9.909973e-01	0.004	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.911717e-01	0.004	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.913357e-01	0.004	0	0
Activation of GABAB receptors	R-HSA-991365	9.919853e-01	0.003	0	0
GABA B receptor activation	R-HSA-977444	9.919853e-01	0.003	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.919853e-01	0.003	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.923085e-01	0.003	0	0
Pyrimidine catabolism	R-HSA-73621	9.927239e-01	0.003	0	0
Protein localization	R-HSA-9609507	9.927511e-01	0.003	0	0
Extracellular matrix organization	R-HSA-1474244	9.931955e-01	0.003	0	0
Methylation	R-HSA-156581	9.933945e-01	0.003	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.933945e-01	0.003	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.940033e-01	0.003	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.941050e-01	0.003	0	0
Selenocysteine synthesis	R-HSA-2408557	9.943791e-01	0.002	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.945560e-01	0.002	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.945560e-01	0.002	0	0
Regulated Necrosis	R-HSA-5218859	9.945861e-01	0.002	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.949692e-01	0.002	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.949692e-01	0.002	0	0
Viral mRNA Translation	R-HSA-192823	9.951419e-01	0.002	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.954355e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.954355e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.955134e-01	0.002	0	0
ECM proteoglycans	R-HSA-3000178	9.958097e-01	0.002	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.958097e-01	0.002	0	0
Retinoid metabolism and transport	R-HSA-975634	9.958097e-01	0.002	0	0
Metabolism of cofactors	R-HSA-8978934	9.958097e-01	0.002	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.958253e-01	0.002	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.959270e-01	0.002	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.960499e-01	0.002	0	0
Purine catabolism	R-HSA-74259	9.961538e-01	0.002	0	0
Azathioprine ADME	R-HSA-9748787	9.963025e-01	0.002	0	0
Immune System	R-HSA-168256	9.966216e-01	0.001	1	0
Complex IV assembly	R-HSA-9864848	9.966434e-01	0.001	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.966434e-01	0.001	0	0
The phototransduction cascade	R-HSA-2514856	9.966434e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.970277e-01	0.001	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.973408e-01	0.001	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.975443e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.977056e-01	0.001	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.979067e-01	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.979308e-01	0.001	0	0
Dectin-2 family	R-HSA-5621480	9.981216e-01	0.001	0	0
Synthesis of PA	R-HSA-1483166	9.981216e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.982307e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.984098e-01	0.001	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.984098e-01	0.001	0	0
GABA receptor activation	R-HSA-977443	9.985950e-01	0.001	0	0
tRNA Aminoacylation	R-HSA-379724	9.985950e-01	0.001	0	0
Pyruvate metabolism	R-HSA-70268	9.990387e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.990460e-01	0.000	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.991450e-01	0.000	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.992393e-01	0.000	0	0
Neurotransmitter release cycle	R-HSA-112310	9.992609e-01	0.000	0	0
Kidney development	R-HSA-9830369	9.992865e-01	0.000	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.993524e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.994280e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.995157e-01	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.995688e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.996010e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.996010e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.996512e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.996940e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997199e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.997527e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.997714e-01	0.000	1	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.997769e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.997865e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.998162e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.998357e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.998706e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.998833e-01	0.000	0	0
rRNA processing	R-HSA-72312	9.998869e-01	0.000	0	0
Translation	R-HSA-72766	9.998916e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.998972e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.999196e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999252e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999386e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999527e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.999572e-01	0.000	0	0
Disease	R-HSA-1643685	9.999585e-01	0.000	1	0
Post-translational protein modification	R-HSA-597592	9.999589e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999627e-01	0.000	1	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999701e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999751e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999756e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999760e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999785e-01	0.000	1	0
Regulation of Complement cascade	R-HSA-977606	9.999792e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999833e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999868e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999871e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999878e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999899e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999925e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999942e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999977e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999979e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999986e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999991e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999994e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999995e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999996e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999997e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999998e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999999e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999999e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Activation of AKT2	R-HSA-165158	1.000000e+00	0.000	1	1
Co-inhibition by CTLA4	R-HSA-389513	1.000000e+00	0.000	1	1
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.000000e+00	0.000	1	1