PKCZ

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00571 S606 Sugiyama DDX3X DBX DDX3 GRSKssRFsGGFGARDYRQssGAssssFsssRAsSsRSGGG
O14920 S177 SIGNOR|PSP IKBKB IKKB EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14920 S181 SIGNOR|PSP IKBKB IKKB IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15371 T49 Sugiyama EIF3D EIF3S7 PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43175 S55 PSP PHGDH PGDH3 NLSKEELIAELQDCEGLIVRsAtKVTADVINAAEKLQVVGR
O43175 T57 PSP PHGDH PGDH3 SKEELIAELQDCEGLIVRsAtKVTADVINAAEKLQVVGRAG
O43175 T78 PSP PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43315 S11 SIGNOR|ELM|PSP AQP9 SSC1 __________MQPEGAEKGKsFKQRLVLKSSLAKETLSEFL
O43315 S222 ELM|PSP AQP9 SSC1 VIASSLGLNSGCAMNPARDLsPRLFTALAGWGFEVFRAGNN
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95863 S249 SIGNOR|PSP SNAI1 SNAH THsDVKKYQCQACARTFsRMsLLHKHQESGCSGCPR_____
O96013 S99 PSP PAK4 KIAA1142 DGALTLLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPE
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S16 SIGNOR ATP1A1 _____MGKGVGRDKyEPAAVsEQGDKKGKKGKKDRDMDELK
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08047 S641 SIGNOR|PSP SP1 TSFP1 GKKKQHICHIQGCGKVYGKTsHLRAHLRWHTGERPFMCTWS
P08047 S670 SIGNOR|PSP SP1 TSFP1 HTGERPFMCTWSYCGKRFtRsDELQRHKRtHtGEKKFACPE
P08047 S702 PSP SP1 TSFP1 GEKKFACPECPKRFMRsDHLsKHIKTHQNKKGGPGVALsVG
P08047 T668 SIGNOR|PSP SP1 TSFP1 RWHTGERPFMCTWSYCGKRFtRsDELQRHKRtHtGEKKFAC
P08047 T681 SIGNOR|PSP SP1 TSFP1 SYCGKRFtRsDELQRHKRtHtGEKKFACPECPKRFMRsDHL
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08670 S34 SIGNOR|PSP VIM MFGGPGtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyA
P08670 S39 PSP VIM GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08670 S56 PSP VIM RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09211 S185 SIGNOR GSTP1 FAEES3 GST3 VLAPGCLDAFPLLSAYVGRLsARPKLKAFLASPEyVNLPIN
P09211 S43 SIGNOR GSTP1 FAEES3 GST3 ADQGQSWKEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtL
P09429 S181 PSP HMGB1 HMG1 AYRAKGKPDAAKKGVVKAEKsKKKKEEEEDEEDEEDEEEEE
P09429 S39 PSP HMGB1 HMG1 FVQtCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAKEKGK
P09429 S53 PSP HMGB1 HMG1 DAsVNFsEFsKKCsERWKtMsAKEKGKFEDMAKADKARYER
P09651 S360 Sugiyama HNRNPA1 HNRPA1 PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651 S363 Sugiyama HNRNPA1 HNRPA1 GGGQyFAKPRNQGGyGGssssssyGsGRRF___________
P09651 S368 Sugiyama HNRNPA1 HNRPA1 FAKPRNQGGyGGssssssyGsGRRF________________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09651 Y366 Sugiyama HNRNPA1 HNRPA1 QyFAKPRNQGGyGGssssssyGsGRRF______________
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598 S303 SIGNOR NCF1 NOXO2 SH3PXD1A sGQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDA
P14598 S304 SIGNOR|PSP NCF1 NOXO2 SH3PXD1A GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598 S315 SIGNOR|PSP NCF1 NOXO2 SH3PXD1A KRGAPPRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQR
P14598 S320 SIGNOR|PSP NCF1 NOXO2 SH3PXD1A PRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQAR
P14598 S328 SIGNOR|PSP NCF1 NOXO2 SH3PXD1A AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14598 S359 SIGNOR NCF1 NOXO2 SH3PXD1A ARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILNRCs
P14598 S370 SIGNOR NCF1 NOXO2 SH3PXD1A LEEERQtQRsKPQPAVPPRPsADLILNRCsESTKRKLASAV
P14598 S379 SIGNOR NCF1 NOXO2 SH3PXD1A sKPQPAVPPRPsADLILNRCsESTKRKLASAV_________
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 S680 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDMLRR
P15104 S322 Sugiyama GLUL GLNS GFHETSNINDFSAGVANRsAsIRIPRTVGQEKKGYFEDRRP
P17252 S657 iPTMNet PRKCA PKCA PRKACA LtPPDQLVIANIDQsDFEGFsyVNPQFVHPILQSAV_____
P17844 S520 Sugiyama DDX5 G17P1 HELR HLR1 GKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAANY
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27448 T564 SIGNOR|PSP MARK3 CTAK1 EMK2 IssAAtPDRIRFPRGtASRstFHGQPRERRtAtYNGPPAsP
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28329 S558 SIGNOR CHAT ALQLAFYRLHRRLVPTYESAsIRRFQEGRVDNIRSAtPEAL
P28329 S594 SIGNOR CHAT tPEALAFVRAVTDHKAAVPAsEKLLLLKDAIRAQTAYTVMA
P29317 S892 PSP EPHA2 ECK DKLIRAPDSLKTLADFDPRVsIRLPstsGsEGVPFRTVsEW
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30086 S153 iPTMNet PEBP1 PBP PEBP CDEPILsNRsGDHRGKFKVAsFRKKyELRAPVAGtCyQAEW
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31751 T309 SIGNOR AKT2 IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31946 S132 ELM|iPTMNet YWHAB TQPESKVFyLKMKGDYFRyLsEVAsGDNKQTtVsNsQQAyQ
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946 T143 SIGNOR|iPTMNet YWHAB MKGDYFRyLsEVAsGDNKQTtVsNsQQAyQEAFEIsKKEMQ
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P35222 S45 SIGNOR|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 WQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQVLyE
P35222 S552 SIGNOR CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35222 S675 SIGNOR CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AAAVLFRMSEDKPQDyKKRLsVELtssLFRTEPMAWNETAD
P35236 S246 SIGNOR PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35568 S1101 SIGNOR IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35568 S307 SIGNOR IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P35568 S323 SIGNOR|ELM|PSP IRS1 sRtEsItAtsPAsMVGGKPGsFRVRAssDGEGtMsRPAsVD
P35568 S441 PSP IRS1 SDGGFISSDEYGSSPCDFRSsFRsVtPDsLGHtPPARGEEE
P35580 S1935 PSP MYH10 EGLSREVSTLKNRLRRGGPIsFsssRSGRRQLHLEGAsLEL
P35580 S1937 SIGNOR|PSP MYH10 LSREVSTLKNRLRRGGPIsFsssRSGRRQLHLEGAsLELsD
P35580 S1956 PSP MYH10 FsssRSGRRQLHLEGAsLELsDDDtEsKtsDVNEtQPPQsE
P35611 S5 ELM ADD1 ADDA ________________MNGDsRAAVVtsPPPttAPHKERyF
P35611 S726 SIGNOR|PSP ADD1 ADDA GsDGSPGKSPsKKKKKFRtPsFLKKSKKKSDS_________
P35612 S713 SIGNOR|PSP ADD2 ADDB sPEGsPsKsPsKKKKKFRTPsFLKKSKKKEKVEs_______
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41594 S840 SIGNOR|iPTMNet GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 SIGNOR|PSP YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 T110 SIGNOR|PSP YAP1 YAP65 KLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPA
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712 T376 SIGNOR|PSP PLA2G4A CPLA2 PLA2G4 MAKYGTFMAPDLFGSKFFMGtVVKKYEENPLHFLMGVWGSA
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49757 S295 iPTMNet NUMB C14orf41 GsFRGFPALsQKMSPFKRQLsLRINELPstMQRKTDFPIKN
P49757 S7 iPTMNet|PSP NUMB C14orf41 ______________MNKLRQsFRRKKDVyVPEASRPHQWQT
P49768 S346 SIGNOR|iPTMNet PSEN1 AD3 PS1 PSNL1 DtVAENDDGGFsEEWEAQRDsHLGPHRstPEsRAAVQELss
P49841 S147 PSP GSK3B YLNLVLDYVPETVYRVARHYsRAKQTLPVIYVKLYMYQLFR
P49841 S9 SIGNOR|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52742 S308 Sugiyama ZNF135 ZNF61 ZNF78L1 HQRTHTGEKPYECSECGKSFsFRSSFSQHERTHTGEKPYEC
P53004 S149 PSP BLVRA BLVR BVR LMEEFAFLKKEVVGKDLLKGsLLFTAGPLEEERFGFPAFSG
P53004 S230 PSP BLVRA BLVR BVR KsPLSWIEEKGPGLKRNRyLsFHFKsGsLENVPNVGVNKNI
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P55040 S261 ELM|PSP GEM KIR LRRDSKEKNERRLAYQKRKEsMPRKARRFWGKIVAKNNKNM
P55196 S216 Sugiyama AFDN AF6 MLLT4 SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55211 S144 SIGNOR|ELM|iPTMNet|PSP CASP9 MCH6 EtPRPVDIGSGGFGDVGALEsLRGNADLAyILSMEPCGHCL
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60484 S380 PSP PTEN MMAC1 TEP1 SSsTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQI
P60484 T382 PSP PTEN MMAC1 TEP1 sTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItK
P60484 T383 PSP PTEN MMAC1 TEP1 TSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61254 S9 Sugiyama RPL26 ____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61587 S210 PSP RND3 ARHE RHO8 RHOE FHVATLACVNKTNKNVKRNKsQRATKRIsHMPSRPELSAVA
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62241 S115 Sugiyama RPS8 OK/SW-cl.83 TLVKNCIVLIDStPYRQWyEsHyALPLGRKKGAKLtPEEEE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62273 S9 Sugiyama RPS29 ____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62312 S74 Sugiyama LSM6 GQLKNKyGDAFIRGNNVLyIstQKRRM______________
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62851 S74 Sugiyama RPS25 tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 Y196 Sugiyama YBX1 NSEP1 YB1 sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P78563 S211 SIGNOR|PSP ADARB1 ADAR2 DRADA2 RED1 YVGSNGDDSFSSSGDLSLSAsPVPAsLAQPPLPVLPPFPPP
P78563 S216 SIGNOR|PSP ADARB1 ADAR2 DRADA2 RED1 GDDSFSSSGDLSLSAsPVPAsLAQPPLPVLPPFPPPSGKNP
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04206 S311 SIGNOR|ELM|iPTMNet|PSP RELA NFKB3 DTDDRHRIEEKRKRtYEtFKsIMKKsPFSGPTDPRPPPRRI
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05513 S148 Sugiyama PRKCZ PKC2 ANGHLFQAKRFNRRAyCGQCsERIWGLARQGYRCINCKLLV
Q05513 S223 Sugiyama PRKCZ PKC2 DLPsEEtDGIAYISSSRKHDsIKDDsEDLKPVIDGMDGIKI
Q05513 S228 Sugiyama PRKCZ PKC2 EtDGIAYISSSRKHDsIKDDsEDLKPVIDGMDGIKISQGLG
Q05513 S482 Sugiyama PRKCZ PKC2 TEDYLFQVILEKPIRIPRFLsVKAsHVLKGFLNKDPKERLG
Q05513 S486 Sugiyama PRKCZ PKC2 LFQVILEKPIRIPRFLsVKAsHVLKGFLNKDPKERLGCRPQ
Q05513 S573 Sugiyama PRKCZ PKC2 TSEPVQLtPDDEDAIKRIDQsEFEGFEYINPLLLSTEEsV_
Q05513 T560 SIGNOR|ELM|iPTMNet PRKCZ PKC2 TDDYGLDNFDTQFTSEPVQLtPDDEDAIKRIDQsEFEGFEY
Q05513 Y143 Sugiyama PRKCZ PKC2 RKLYRANGHLFQAKRFNRRAyCGQCsERIWGLARQGYRCIN
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05655 S664 iPTMNet PRKCD PKCD LsysDKNLIDsMDQsAFAGFsFVNPKFEHLLED________
Q07812 S184 SIGNOR|PSP BAX BCL2L4 YFGtPTWQtVtIFVAGVLTAsLtIWKKMG____________
Q12933 S55 SIGNOR|PSP TRAF2 TRAP3 SACRNVLRRPFQAQCGHRYCsFCLASILSSGPQNCAACVHE
Q13118 S384 PSP KLF10 TIEG TIEG1 SRIRSHICSHPGCGKTYFKSsHLKAHTRTHTGEKPFSCSWK
Q13118 T445 PSP KLF10 TIEG TIEG1 GEKKFACPMCDRRFMRSDHLtKHARRHLSAKKLPNWQMEVS
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15084 S389 Sugiyama PDIA6 ERP5 P5 TXNDC7 FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15109 S391 PSP AGER RAGE EERKAPENQEEEEERAELNQsEEPEAGEssTGGP_______
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15466 T55 PSP NR0B2 SHP PRSRCLCRQHRPVQLCAPHRtCREALDVLAKTVAFLRNLPS
Q15831 S307 SIGNOR|PSP STK11 LKB1 PJS KGMLEYEPAKRFSIRQIRQHsWFRKKHPPAEAPVPIPPsPD
Q15831 S428 SIGNOR|PSP STK11 LKB1 PJS GRAPNPARKACSASSKIRRLsACKQQ_______________
Q16236 S40 PSP NFE2L2 NRF2 IDILWRQDIDLGVSREVFDFsQRRKEYELEKQKKLEKERQE
Q16612 S59 SIGNOR|PSP NREP C5orf13 P311 KKNDETNAASLTPLGSSELRsPRISYLHFF___________
Q16625 T403 PSP OCLN AKGRAGRSKRTEQDHyEtDyttGGEsCDELEEDWIREYPPI
Q16625 T404 PSP OCLN KGRAGRSKRTEQDHyEtDyttGGEsCDELEEDWIREYPPIt
Q16625 T424 PSP OCLN tGGEsCDELEEDWIREYPPItSDQQRQLYKRNFDtGLQEyK
Q16625 T438 PSP OCLN REYPPItSDQQRQLYKRNFDtGLQEyKsLQSELDEINKELS
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5JVS0 T354 SIGNOR|iPTMNet|PSP HABP4 MVKDDYEDDSHVFRKPANDItSQLEINFGNLPRPGRGARGG
Q5JVS0 T375 SIGNOR|iPTMNet|PSP HABP4 SQLEINFGNLPRPGRGARGGtRGGRGRIRRAENYGPRAEVV
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6STE5 S247 PSP SMARCD3 BAF60C HRTPTTQETDGFQVKRPGDLsVRCTLLLMLDYQPPQFKLDP
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZI7 T596 SIGNOR|PSP MARK2 EMK1 sssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPyGVt
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX03 S975 SIGNOR|iPTMNet|PSP WWC1 KIAA0869 KIBRA KPPFVRNSLERRSVRMKRPSsVKsLRSERLIRTSLDLELDL
Q8IX03 S978 SIGNOR|iPTMNet|PSP WWC1 KIAA0869 KIBRA FVRNSLERRSVRMKRPSsVKsLRSERLIRTSLDLELDLQAT
Q8IXH6 S208 Sugiyama TP53INP2 C20orf110 DOR PINH AVQRQNRARESRPRRSKNQSsFIyQPCQRQFNY________
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N2W9 S18 SIGNOR|PSP PIAS4 PIASG ___MAAELVEAKNMVMSFRVsDLQMLLGFVGRSKSGLKHEL
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0 S827 SIGNOR PARD3 PAR3 PAR3A sLsPDVDPVLAFQREGFGRQsMsEKRtKQFsDAsQLDFVKT
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96A00 T38 SIGNOR|ELM|iPTMNet|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96RI1 T456 SIGNOR NR1H4 BAR FXR HRR1 RIP14 HQPENPQHFACLLGRLTELRtFNHHHAEMLMSWRVNDHKFT
Q99613 S639 Sugiyama EIF3C EIF3S8 CAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQERN
Q99700 S505 Sugiyama ATXN2 ATX2 SCA2 TNRC13 SINTRENKYIPPGQRNREVIsWGsGRQNsPRMGQPGsGSMP
Q99700 S508 Sugiyama ATXN2 ATX2 SCA2 TNRC13 TRENKYIPPGQRNREVIsWGsGRQNsPRMGQPGsGSMPSRs
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQ52 S212 Sugiyama ELAC2 HPC2 GKHQPWQsPERPLsRLsPERssDsEsNENEPHLPHGVsQRR
Q9BUJ2 S512 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 IQIAARKKRNyILDQtNVyGsAQRRKMRPFEGFQRKAIVIC
Q9GZQ8 T50 SIGNOR|PSP MAP1LC3B MAP1ALC3 KIPVIIERYKGEKQLPVLDKtKFLVPDHVNMSELIKIIRRR
Q9NPB6 S345 SIGNOR|PSP PARD6A PAR6A DQEQASSGWGSRIRGDGSGFsL___________________
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NYF8 S319 Sugiyama BCLAF1 BTF KIAA0164 RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9P286 S99 PSP PAK5 KIAA1264 PAK7 ETSINGLLEDFDNISVTRSNsLRKESPPTPDQGASSHGPGH
Q9P2T1 S37 Sugiyama GMPR2 LRPKRSTLKsRsEVDLTRSFsFRNSKQTYSGVPIIAANMDT
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UBS0 S473 ELM|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9UJZ1 S17 PSP STOML2 SLP2 HSPC108 ____MLARAARGTGALLLRGsLLASGRAPRRASSGLPRNTV
Q9ULX6 T267 Sugiyama AKAP8L NAKAP NAKAP95 HRIHFB2018 RFGFGFGNGMKQMRRTWKTWtTADFRTKKKKRKQGGsPDEP
Q9UNX3 S9 Sugiyama RPL26L1 RPL26P1 ____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y243 S472 SIGNOR AKT3 PKBG YDEDGMDCMDNERRPHFPQFsysAsGRE_____________
Q9Y243 T305 SIGNOR AKT3 PKBG IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2W1 S257 Sugiyama THRAP3 BCLAF2 TRAP150 sAVsELsPRERsPALKsPLQsVVVRRRsPRPsPVPKPSPPL
Q9Y6Q9 S1033 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 GMLSMEQVSHGTQNRPLLRNsLDDLVGPPsNLEGQsDERAL
Q9Y6Q9 S1042 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 HGTQNRPLLRNsLDDLVGPPsNLEGQsDERALLDQLHtLLs
Q9Y6Q9 S1048 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 PLLRNsLDDLVGPPsNLEGQsDERALLDQLHtLLsNtDAtG
Q9Y6Q9 S1062 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 sNLEGQsDERALLDQLHtLLsNtDAtGLEEIDRALGIPELV
Q9Y6Q9 T1059 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 GPPsNLEGQsDERALLDQLHtLLsNtDAtGLEEIDRALGIP
Q9Y6Q9 T1064 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 LEGQsDERALLDQLHtLLsNtDAtGLEEIDRALGIPELVNQ
Q9Y6Q9 T1067 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 QsDERALLDQLHtLLsNtDAtGLEEIDRALGIPELVNQGQA
Q9Y6Q9 T1114 PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 AFQGQEAAVMMDQKAGLYGQtYPAQGPPMQGGFHLQGQSPS
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.377654e-12 11.624 0 0
Signal Transduction R-HSA-162582 9.241830e-12 11.034 1 0
Cell Cycle, Mitotic R-HSA-69278 2.751889e-10 9.560 0 0
Axon guidance R-HSA-422475 4.973149e-10 9.303 0 0
Nervous system development R-HSA-9675108 2.726899e-09 8.564 0 0
Apoptotic execution phase R-HSA-75153 4.377127e-09 8.359 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.037072e-08 7.691 0 0
Cell Cycle Checkpoints R-HSA-69620 3.084848e-08 7.511 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.018792e-07 6.992 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.500780e-08 7.022 0 0
M Phase R-HSA-68886 1.620190e-06 5.790 0 0
Cellular Senescence R-HSA-2559583 1.922077e-06 5.716 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.164920e-06 5.665 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.164920e-06 5.665 0 0
G alpha (12/13) signalling events R-HSA-416482 2.399522e-06 5.620 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.695587e-06 5.569 0 0
NRAGE signals death through JNK R-HSA-193648 4.550983e-06 5.342 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.922550e-06 5.308 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.314279e-06 5.275 0 0
ESR-mediated signaling R-HSA-8939211 5.683799e-06 5.245 1 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.947437e-06 5.226 0 0
Apoptosis R-HSA-109581 8.624537e-06 5.064 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.092765e-05 4.961 1 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.296699e-05 4.887 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.396844e-05 4.855 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.343540e-05 4.476 0 0
Mitotic Anaphase R-HSA-68882 3.419429e-05 4.466 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.838364e-05 4.416 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.808437e-05 4.236 0 0
Programmed Cell Death R-HSA-5357801 5.803265e-05 4.236 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.233024e-05 4.205 0 0
Signaling by VEGF R-HSA-194138 6.377392e-05 4.195 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.617552e-05 4.179 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.955174e-05 4.158 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.789250e-05 4.109 0 0
Gene expression (Transcription) R-HSA-74160 8.029248e-05 4.095 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.777062e-05 4.057 0 0
Regulation of TP53 Activity R-HSA-5633007 9.856024e-05 4.006 0 0
mRNA 3'-end processing R-HSA-72187 1.027907e-04 3.988 0 0
Mitotic Prophase R-HSA-68875 1.108945e-04 3.955 0 0
HATs acetylate histones R-HSA-3214847 1.117941e-04 3.952 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.210953e-04 3.917 0 0
Mitotic Prometaphase R-HSA-68877 1.418797e-04 3.848 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.389614e-04 3.857 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.389614e-04 3.857 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.499026e-04 3.824 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.689444e-04 3.772 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.962254e-04 3.707 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.156064e-04 3.666 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.156064e-04 3.666 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.791986e-04 3.554 0 0
mRNA Splicing R-HSA-72172 2.927146e-04 3.534 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.402583e-04 3.468 0 0
Interleukin-37 signaling R-HSA-9008059 3.387788e-04 3.470 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.808975e-04 3.419 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.763276e-04 3.424 0 0
RNA Polymerase II Transcription R-HSA-73857 3.886527e-04 3.410 0 0
Semaphorin interactions R-HSA-373755 4.117452e-04 3.385 0 0
Signaling by ROBO receptors R-HSA-376176 4.124203e-04 3.385 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.416495e-04 3.355 0 0
Signaling by Hippo R-HSA-2028269 4.707047e-04 3.327 0 0
FOXO-mediated transcription R-HSA-9614085 4.969371e-04 3.304 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.969371e-04 3.304 0 0
Oncogene Induced Senescence R-HSA-2559585 5.703857e-04 3.244 0 0
Chromatin organization R-HSA-4839726 5.733734e-04 3.242 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.355440e-04 3.197 0 0
Chromatin modifying enzymes R-HSA-3247509 6.566428e-04 3.183 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.413445e-04 3.130 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.125942e-04 3.147 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.586515e-04 3.120 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.586515e-04 3.120 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.365151e-04 3.078 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.920716e-04 3.050 0 0
Generic Transcription Pathway R-HSA-212436 8.943251e-04 3.049 0 0
Separation of Sister Chromatids R-HSA-2467813 9.510516e-04 3.022 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.012461e-03 2.995 0 0
Metalloprotease DUBs R-HSA-5689901 1.022827e-03 2.990 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.180061e-03 2.928 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.199423e-03 2.921 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.247204e-03 2.904 0 0
RAF activation R-HSA-5673000 1.235637e-03 2.908 0 0
Signaling by ERBB2 R-HSA-1227986 1.277500e-03 2.894 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.254862e-03 2.901 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.289917e-03 2.889 0 0
EPH-Ephrin signaling R-HSA-2682334 1.315685e-03 2.881 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.443942e-03 2.840 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.458978e-03 2.836 1 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.588520e-03 2.799 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.786190e-03 2.748 0 0
Signaling by AXIN mutants R-HSA-4839735 1.808881e-03 2.743 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.808881e-03 2.743 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.843860e-03 2.734 0 0
Netrin-1 signaling R-HSA-373752 1.986443e-03 2.702 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.987314e-03 2.702 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.987883e-03 2.702 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.097321e-03 2.678 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.240807e-03 2.650 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.309612e-03 2.636 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.215256e-03 2.655 1 0
Deubiquitination R-HSA-5688426 2.390140e-03 2.622 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.391230e-03 2.621 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.676446e-03 2.572 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.676446e-03 2.572 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.676446e-03 2.572 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.676446e-03 2.572 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.676446e-03 2.572 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.676446e-03 2.572 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.981802e-03 2.526 0 0
Signaling by RAS mutants R-HSA-6802949 2.900103e-03 2.538 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.900103e-03 2.538 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.900103e-03 2.538 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.900103e-03 2.538 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.998524e-03 2.523 0 0
Meiosis R-HSA-1500620 3.003618e-03 2.522 0 0
Death Receptor Signaling R-HSA-73887 3.040217e-03 2.517 0 0
Signaling by EGFR R-HSA-177929 3.220253e-03 2.492 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.247739e-03 2.488 0 0
Nuclear import of Rev protein R-HSA-180746 3.247739e-03 2.488 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.610999e-03 2.442 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.610999e-03 2.442 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.493653e-03 2.457 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.738254e-03 2.427 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.138270e-03 2.383 0 0
Meiotic synapsis R-HSA-1221632 4.312994e-03 2.365 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.312994e-03 2.365 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.376518e-03 2.359 0 0
Post NMDA receptor activation events R-HSA-438064 4.447357e-03 2.352 0 0
Signaling by PTK6 R-HSA-8848021 4.516818e-03 2.345 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.516818e-03 2.345 0 0
Signaling by APC mutants R-HSA-4839744 4.829271e-03 2.316 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.829271e-03 2.316 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.829271e-03 2.316 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.829271e-03 2.316 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.880388e-03 2.312 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.409075e-03 2.267 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.269159e-03 2.278 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.269159e-03 2.278 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.409075e-03 2.267 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.238891e-03 2.281 0 0
FLT3 Signaling R-HSA-9607240 5.269159e-03 2.278 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.818064e-03 2.235 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.873753e-03 2.231 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.873753e-03 2.231 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.915308e-03 2.228 0 0
DNA methylation R-HSA-5334118 5.946369e-03 2.226 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.043753e-03 2.219 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.043753e-03 2.219 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.107543e-03 2.214 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.678288e-03 2.175 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.678288e-03 2.175 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.769707e-03 2.169 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.769707e-03 2.169 0 0
Cellular responses to stimuli R-HSA-8953897 6.499604e-03 2.187 0 0
Meiotic recombination R-HSA-912446 6.781974e-03 2.169 0 0
Activation of RAC1 R-HSA-428540 6.928458e-03 2.159 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.296651e-03 2.137 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.918178e-03 2.160 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.336304e-03 2.135 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.907840e-03 2.161 0 0
Activation of BH3-only proteins R-HSA-114452 7.336304e-03 2.135 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.234020e-03 2.141 0 0
MTOR signalling R-HSA-165159 7.495211e-03 2.125 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.119129e-03 2.148 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.985898e-03 2.156 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.928458e-03 2.159 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.899647e-03 2.161 0 0
Signaling by NTRKs R-HSA-166520 8.000908e-03 2.097 0 0
Cell junction organization R-HSA-446728 8.072561e-03 2.093 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.482442e-03 2.071 1 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.510249e-03 2.070 0 0
Gap junction degradation R-HSA-190873 8.784421e-03 2.056 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.964622e-03 2.047 0 0
Signaling by WNT R-HSA-195721 9.337483e-03 2.030 0 0
Rap1 signalling R-HSA-392517 9.365485e-03 2.028 0 0
Cell-Cell communication R-HSA-1500931 9.454358e-03 2.024 0 0
Breakdown of the nuclear lamina R-HSA-352238 9.870761e-03 2.006 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.638285e-03 2.016 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.638285e-03 2.016 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.975430e-03 2.001 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.010774e-02 1.995 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.062049e-02 1.974 0 0
RMTs methylate histone arginines R-HSA-3214858 1.041483e-02 1.982 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.005208e-02 1.998 0 0
Signaling by ALK in cancer R-HSA-9700206 1.005208e-02 1.998 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.975430e-03 2.001 0 0
Ub-specific processing proteases R-HSA-5689880 1.067338e-02 1.972 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.071135e-02 1.970 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.071135e-02 1.970 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.071135e-02 1.970 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.087236e-02 1.964 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.150961e-02 1.939 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.192571e-02 1.924 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.192571e-02 1.924 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.192571e-02 1.924 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.192571e-02 1.924 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.216568e-02 1.915 0 0
Nucleosome assembly R-HSA-774815 1.217652e-02 1.914 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.217652e-02 1.914 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.223598e-02 1.912 0 0
HDACs deacetylate histones R-HSA-3214815 1.226789e-02 1.911 0 0
MAP2K and MAPK activation R-HSA-5674135 1.400064e-02 1.854 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.400064e-02 1.854 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.323886e-02 1.878 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.307255e-02 1.884 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.400064e-02 1.854 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.260466e-02 1.899 0 0
Cellular responses to stress R-HSA-2262752 1.245976e-02 1.904 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.260466e-02 1.899 0 0
Interleukin-12 signaling R-HSA-9020591 1.295114e-02 1.888 0 0
MAPK family signaling cascades R-HSA-5683057 1.406010e-02 1.852 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.416259e-02 1.849 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.456221e-02 1.837 0 0
DNA Double Strand Break Response R-HSA-5693606 1.542017e-02 1.812 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.608466e-02 1.794 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.615355e-02 1.792 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.615355e-02 1.792 0 0
SOS-mediated signalling R-HSA-112412 1.615355e-02 1.792 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.632475e-02 1.787 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.632475e-02 1.787 0 0
Long-term potentiation R-HSA-9620244 1.666010e-02 1.778 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.666010e-02 1.778 1 1
Diseases of programmed cell death R-HSA-9645723 1.684806e-02 1.773 0 0
L1CAM interactions R-HSA-373760 1.701102e-02 1.769 0 0
Gene Silencing by RNA R-HSA-211000 1.714024e-02 1.766 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.754200e-02 1.756 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.777819e-02 1.750 0 0
Polo-like kinase mediated events R-HSA-156711 2.057822e-02 1.687 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.019551e-02 1.695 0 0
Ephrin signaling R-HSA-3928664 2.057822e-02 1.687 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.057822e-02 1.687 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.032510e-02 1.692 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.975931e-02 1.704 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.975931e-02 1.704 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.950546e-02 1.710 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.862127e-02 1.730 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.057822e-02 1.687 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.847498e-02 1.733 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.105383e-02 1.677 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.105383e-02 1.677 0 0
Downstream signal transduction R-HSA-186763 2.118697e-02 1.674 0 0
Trafficking of AMPA receptors R-HSA-399719 2.118697e-02 1.674 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.118697e-02 1.674 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.118697e-02 1.674 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.173205e-02 1.663 0 0
Signalling to ERKs R-HSA-187687 2.173205e-02 1.663 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.193784e-02 1.659 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 2.232815e-02 1.651 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.232815e-02 1.651 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.232815e-02 1.651 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.232815e-02 1.651 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.282637e-02 1.642 0 0
Adherens junctions interactions R-HSA-418990 2.313525e-02 1.636 0 0
Formation of annular gap junctions R-HSA-196025 2.317888e-02 1.635 0 0
Activation of RAS in B cells R-HSA-1169092 2.317888e-02 1.635 0 0
Adrenoceptors R-HSA-390696 2.317888e-02 1.635 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.346737e-02 1.630 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.560019e-02 1.592 0 0
Packaging Of Telomere Ends R-HSA-171306 2.424934e-02 1.615 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.505304e-02 1.601 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.539534e-02 1.595 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.539534e-02 1.595 0 0
G0 and Early G1 R-HSA-1538133 2.505304e-02 1.601 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.735071e-02 1.563 0 0
HIV Life Cycle R-HSA-162587 2.568035e-02 1.590 0 0
Signaling by WNT in cancer R-HSA-4791275 2.505304e-02 1.601 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.539534e-02 1.595 0 0
Calmodulin induced events R-HSA-111933 2.539538e-02 1.595 0 0
CaM pathway R-HSA-111997 2.539538e-02 1.595 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.453736e-02 1.610 0 0
Developmental Biology R-HSA-1266738 2.357557e-02 1.628 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.593902e-02 1.586 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.766952e-02 1.558 0 0
Signaling by TGFBR3 R-HSA-9839373 2.874334e-02 1.541 0 0
G2/M Checkpoints R-HSA-69481 2.895284e-02 1.538 0 0
Selective autophagy R-HSA-9663891 2.911556e-02 1.536 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.921421e-02 1.534 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.940665e-02 1.532 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.940665e-02 1.532 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.940665e-02 1.532 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.940665e-02 1.532 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.016638e-02 1.520 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.016638e-02 1.520 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.049152e-02 1.516 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.054052e-02 1.515 0 0
Metabolism of RNA R-HSA-8953854 3.054971e-02 1.515 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.072170e-02 1.513 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.081651e-02 1.511 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.141851e-02 1.503 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.141851e-02 1.503 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.141851e-02 1.503 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.141851e-02 1.503 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.141851e-02 1.503 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.141851e-02 1.503 0 0
Formation of definitive endoderm R-HSA-9823730 3.141851e-02 1.503 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.192467e-02 1.496 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.193933e-02 1.496 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.459753e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.459753e-02 1.461 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.459753e-02 1.461 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.459753e-02 1.461 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.459753e-02 1.461 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.459753e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.459753e-02 1.461 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.459753e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.459753e-02 1.461 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.703362e-02 1.431 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.703362e-02 1.431 0 0
MET interacts with TNS proteins R-HSA-8875513 3.703362e-02 1.431 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.930282e-02 1.406 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.930282e-02 1.406 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.930282e-02 1.406 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.930282e-02 1.406 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.538903e-02 1.451 0 0
TGFBR3 expression R-HSA-9839394 3.943428e-02 1.404 0 0
snRNP Assembly R-HSA-191859 3.859904e-02 1.413 0 0
Metabolism of non-coding RNA R-HSA-194441 3.859904e-02 1.413 0 0
GPER1 signaling R-HSA-9634597 3.705652e-02 1.431 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.840445e-02 1.416 0 0
Defective pyroptosis R-HSA-9710421 3.816319e-02 1.418 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.319287e-02 1.479 0 0
Cell-cell junction organization R-HSA-421270 3.869375e-02 1.412 0 0
TBC/RABGAPs R-HSA-8854214 3.816319e-02 1.418 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.427631e-02 1.465 0 0
Depurination R-HSA-73927 3.404205e-02 1.468 0 0
Mitophagy R-HSA-5205647 3.968835e-02 1.401 0 0
Translation initiation complex formation R-HSA-72649 4.022604e-02 1.395 0 0
Signaling by NOTCH R-HSA-157118 4.112533e-02 1.386 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.157124e-02 1.381 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.248772e-02 1.372 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.248772e-02 1.372 0 0
Regulation of CDH11 function R-HSA-9762292 4.248772e-02 1.372 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.302979e-02 1.366 0 0
Kinesins R-HSA-983189 4.302979e-02 1.366 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.328406e-02 1.364 0 0
Membrane Trafficking R-HSA-199991 4.412783e-02 1.355 0 0
Interleukin-12 family signaling R-HSA-447115 4.435515e-02 1.353 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.562943e-02 1.341 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.642668e-02 1.333 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.661998e-02 1.331 0 0
Rab regulation of trafficking R-HSA-9007101 4.676375e-02 1.330 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.690058e-02 1.329 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.885588e-02 1.311 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.958519e-02 1.305 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.998698e-02 1.301 0 0
G-protein mediated events R-HSA-112040 5.026642e-02 1.299 0 0
Regulation of gap junction activity R-HSA-191650 5.768383e-02 1.239 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.768383e-02 1.239 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.768383e-02 1.239 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.768383e-02 1.239 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.768383e-02 1.239 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.768383e-02 1.239 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.910266e-02 1.228 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.910266e-02 1.228 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 5.910266e-02 1.228 0 0
Disinhibition of SNARE formation R-HSA-114516 5.910266e-02 1.228 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.910266e-02 1.228 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.492298e-02 1.260 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.492298e-02 1.260 0 0
Erythropoietin activates RAS R-HSA-9027284 6.065515e-02 1.217 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.270680e-02 1.278 0 0
Pyroptosis R-HSA-5620971 6.276814e-02 1.202 0 0
RET signaling R-HSA-8853659 5.223196e-02 1.282 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.170930e-02 1.210 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.503958e-02 1.259 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.849545e-02 1.233 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.849545e-02 1.233 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.849545e-02 1.233 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.950912e-02 1.225 0 0
Recycling pathway of L1 R-HSA-437239 6.147822e-02 1.211 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.130654e-02 1.212 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.601901e-02 1.252 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.847304e-02 1.233 0 0
Integrin signaling R-HSA-354192 6.130654e-02 1.212 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.292234e-02 1.201 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.065515e-02 1.217 0 0
p38MAPK events R-HSA-171007 6.065515e-02 1.217 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.940231e-02 1.226 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.305719e-02 1.200 0 0
mTORC1-mediated signalling R-HSA-166208 5.409567e-02 1.267 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.599994e-02 1.252 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.599994e-02 1.252 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.244296e-02 1.205 0 0
Opioid Signalling R-HSA-111885 5.186017e-02 1.285 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.419748e-02 1.266 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.940231e-02 1.226 0 0
Neuronal System R-HSA-112316 5.159924e-02 1.287 0 0
Signaling by Interleukins R-HSA-449147 5.889756e-02 1.230 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.940231e-02 1.226 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.130654e-02 1.212 0 0
Diseases of DNA repair R-HSA-9675135 5.492735e-02 1.260 0 0
Reproduction R-HSA-1474165 5.886498e-02 1.230 0 0
Cleavage of the damaged purine R-HSA-110331 5.940231e-02 1.226 0 0
Ca-dependent events R-HSA-111996 6.436970e-02 1.191 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.436970e-02 1.191 0 0
Depyrimidination R-HSA-73928 6.436970e-02 1.191 0 0
IGF1R signaling cascade R-HSA-2428924 6.437193e-02 1.191 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.614112e-02 1.180 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.614112e-02 1.180 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.722576e-02 1.172 0 0
Co-stimulation by CD28 R-HSA-389356 6.853077e-02 1.164 0 0
UCH proteinases R-HSA-5689603 6.855264e-02 1.164 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.924421e-02 1.160 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.924421e-02 1.160 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.924421e-02 1.160 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.924421e-02 1.160 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.984102e-02 1.156 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.016891e-02 1.154 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.059121e-02 1.151 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.066057e-02 1.151 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 7.090166e-02 1.149 0 0
Oligomerization of connexins into connexons R-HSA-190704 7.090166e-02 1.149 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.090166e-02 1.149 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.090166e-02 1.149 0 0
Transport of connexins along the secretory pathway R-HSA-190827 7.090166e-02 1.149 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.112068e-02 1.148 0 0
Signaling by FGFR4 R-HSA-5654743 7.206311e-02 1.142 0 0
DARPP-32 events R-HSA-180024 7.215378e-02 1.142 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.215378e-02 1.142 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.387001e-02 1.132 0 0
Influenza Infection R-HSA-168255 7.419060e-02 1.130 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.492208e-02 1.125 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.535523e-02 1.123 0 0
Homology Directed Repair R-HSA-5693538 7.568390e-02 1.121 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.759810e-02 1.110 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.759810e-02 1.110 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.833703e-02 1.106 0 0
Signal amplification R-HSA-392518 7.909143e-02 1.102 0 0
G alpha (z) signalling events R-HSA-418597 7.942595e-02 1.100 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.101186e-02 1.091 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.236297e-02 1.084 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.236297e-02 1.084 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.236297e-02 1.084 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 8.264104e-02 1.083 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 8.264104e-02 1.083 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 8.264104e-02 1.083 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 8.264104e-02 1.083 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.264104e-02 1.083 0 0
NrCAM interactions R-HSA-447038 8.264104e-02 1.083 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.466913e-02 1.072 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.519904e-02 1.070 0 0
MET activates RAS signaling R-HSA-8851805 8.542636e-02 1.068 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.542636e-02 1.068 0 0
Disorders of Nervous System Development R-HSA-9697154 8.542636e-02 1.068 0 0
Pervasive developmental disorders R-HSA-9005895 8.542636e-02 1.068 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.588038e-02 1.066 1 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.149457e-01 0.940 0 0
Regulation of TP53 Expression R-HSA-6804754 1.149457e-01 0.940 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.149457e-01 0.940 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.149457e-01 0.940 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.149457e-01 0.940 0 0
Diseases of cellular response to stress R-HSA-9675132 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.149457e-01 0.940 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.149457e-01 0.940 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.149457e-01 0.940 0 0
Potassium transport channels R-HSA-1296067 1.149457e-01 0.940 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.149457e-01 0.940 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.113956e-01 0.953 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 9.862531e-02 1.006 1 1
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 9.862531e-02 1.006 0 0
Disorders of Developmental Biology R-HSA-9675151 8.772346e-02 1.057 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.772346e-02 1.057 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.721408e-02 1.059 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.010091e-01 0.996 0 0
EGFR downregulation R-HSA-182971 9.339763e-02 1.030 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.052530e-01 0.978 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.731271e-02 1.059 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.018982e-01 0.992 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.033686e-01 0.986 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.033686e-01 0.986 0 0
Signaling by FGFR3 R-HSA-5654741 8.916007e-02 1.050 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.014316e-01 0.994 0 0
Signalling to RAS R-HSA-167044 8.721408e-02 1.059 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.113956e-01 0.953 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.034090e-01 0.985 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.906290e-02 1.050 0 0
G2/M Transition R-HSA-69275 1.058733e-01 0.975 0 0
Neurexins and neuroligins R-HSA-6794361 1.018982e-01 0.992 0 0
S Phase R-HSA-69242 9.541524e-02 1.020 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 9.862531e-02 1.006 0 0
Calcineurin activates NFAT R-HSA-2025928 9.862531e-02 1.006 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.587737e-02 1.018 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.110631e-01 0.954 0 0
DNA Repair R-HSA-73894 9.926185e-02 1.003 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.034090e-01 0.985 0 0
Transmission across Chemical Synapses R-HSA-112315 1.037552e-01 0.984 0 0
DAG and IP3 signaling R-HSA-1489509 8.916007e-02 1.050 0 0
tRNA processing in the nucleus R-HSA-6784531 8.986354e-02 1.046 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.010091e-01 0.996 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.916007e-02 1.050 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.047929e-01 0.980 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.010091e-01 0.996 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.436676e-02 1.025 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.107240e-01 0.956 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.857092e-02 1.006 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.156766e-01 0.937 0 0
Notch-HLH transcription pathway R-HSA-350054 1.159189e-01 0.936 0 0
Muscle contraction R-HSA-397014 1.161206e-01 0.935 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.163437e-01 0.934 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.168468e-01 0.932 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.179178e-01 0.928 0 0
Nuclear RNA decay R-HSA-9930044 1.179178e-01 0.928 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.179714e-01 0.928 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.184263e-01 0.927 0 0
Peptide chain elongation R-HSA-156902 1.186517e-01 0.926 0 0
Macroautophagy R-HSA-1632852 1.201180e-01 0.920 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.202596e-01 0.920 0 0
Apoptotic factor-mediated response R-HSA-111471 1.203636e-01 0.920 0 0
Tie2 Signaling R-HSA-210993 1.203636e-01 0.920 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.217054e-01 0.915 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.219934e-01 0.914 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.219934e-01 0.914 0 0
Regulation of KIT signaling R-HSA-1433559 1.231007e-01 0.910 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.231007e-01 0.910 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.248861e-01 0.903 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.259677e-01 0.900 0 0
HIV Infection R-HSA-162906 1.285420e-01 0.891 0 0
Chromosome Maintenance R-HSA-73886 1.310595e-01 0.883 0 0
Cellular response to heat stress R-HSA-3371556 1.310595e-01 0.883 0 0
Striated Muscle Contraction R-HSA-390522 1.313744e-01 0.881 0 0
Glycolysis R-HSA-70171 1.344942e-01 0.871 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.347165e-01 0.871 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.347165e-01 0.871 0 0
KIT mutants bind TKIs R-HSA-9669921 1.347165e-01 0.871 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.347165e-01 0.871 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.347165e-01 0.871 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.347165e-01 0.871 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.347165e-01 0.871 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.347165e-01 0.871 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.347165e-01 0.871 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.347165e-01 0.871 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.347165e-01 0.871 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.347165e-01 0.871 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.347165e-01 0.871 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.347165e-01 0.871 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.347165e-01 0.871 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.347165e-01 0.871 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.347165e-01 0.871 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.347165e-01 0.871 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.347165e-01 0.871 0 0
Defective OGG1 Localization R-HSA-9657050 1.347165e-01 0.871 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.347165e-01 0.871 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.347165e-01 0.871 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.347165e-01 0.871 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.347165e-01 0.871 0 0
Base Excision Repair R-HSA-73884 1.355010e-01 0.868 0 0
Signaling by ALK R-HSA-201556 1.360866e-01 0.866 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.369211e-01 0.864 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.386434e-01 0.858 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.399448e-01 0.854 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.399448e-01 0.854 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.399448e-01 0.854 0 0
Axonal growth stimulation R-HSA-209563 1.639871e-01 0.785 0 0
MET activates PTPN11 R-HSA-8865999 1.639871e-01 0.785 0 0
CREB phosphorylation R-HSA-199920 1.433591e-01 0.844 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.779132e-01 0.750 0 0
Netrin mediated repulsion signals R-HSA-418886 1.779132e-01 0.750 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.779132e-01 0.750 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.474678e-01 0.831 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.144445e-01 0.669 0 0
Type I hemidesmosome assembly R-HSA-446107 2.144445e-01 0.669 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.144445e-01 0.669 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.144445e-01 0.669 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.443837e-01 0.840 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.443837e-01 0.840 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.443837e-01 0.840 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.443837e-01 0.840 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.443837e-01 0.840 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.671189e-01 0.777 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.911511e-01 0.719 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.911511e-01 0.719 0 0
Deadenylation of mRNA R-HSA-429947 1.489228e-01 0.827 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.489228e-01 0.827 0 0
HDMs demethylate histones R-HSA-3214842 1.669100e-01 0.778 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.003267e-01 0.698 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.003267e-01 0.698 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.858008e-01 0.731 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.055210e-01 0.687 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.055210e-01 0.687 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.055210e-01 0.687 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.055210e-01 0.687 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.055210e-01 0.687 0 0
Transcription of the HIV genome R-HSA-167172 1.451999e-01 0.838 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.444186e-01 0.840 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.437028e-01 0.843 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.065063e-01 0.685 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.027721e-01 0.693 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.461241e-01 0.835 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.937292e-01 0.713 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.123314e-01 0.673 0 0
Signaling by FGFR2 R-HSA-5654738 1.453121e-01 0.838 0 0
RUNX2 regulates bone development R-HSA-8941326 1.762291e-01 0.754 0 0
Co-inhibition by PD-1 R-HSA-389948 1.494785e-01 0.825 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.787233e-01 0.748 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.787233e-01 0.748 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.558627e-01 0.807 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.670532e-01 0.777 0 0
DAP12 signaling R-HSA-2424491 1.558627e-01 0.807 0 0
Signaling by SCF-KIT R-HSA-1433557 2.096709e-01 0.678 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.003267e-01 0.698 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.678191e-01 0.775 0 0
Activation of SMO R-HSA-5635838 1.671189e-01 0.777 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.036596e-01 0.691 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.552371e-01 0.809 0 0
Signaling by FGFR1 R-HSA-5654736 1.435558e-01 0.843 0 0
Gap junction trafficking and regulation R-HSA-157858 2.090934e-01 0.680 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.904918e-01 0.720 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.787233e-01 0.748 0 0
Myogenesis R-HSA-525793 1.858008e-01 0.731 0 0
DCC mediated attractive signaling R-HSA-418885 1.443837e-01 0.840 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.090934e-01 0.680 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.090934e-01 0.680 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.523008e-01 0.817 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.573190e-01 0.803 0 0
RAB geranylgeranylation R-HSA-8873719 1.930300e-01 0.714 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.455990e-01 0.837 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.090934e-01 0.680 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.784420e-01 0.749 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.144445e-01 0.669 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.036596e-01 0.691 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.036596e-01 0.691 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.127493e-01 0.672 0 0
Mitochondrial biogenesis R-HSA-1592230 2.029814e-01 0.693 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.489379e-01 0.827 0 0
Repression of WNT target genes R-HSA-4641265 2.036596e-01 0.691 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.930300e-01 0.714 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.930300e-01 0.714 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.930300e-01 0.714 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.930300e-01 0.714 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.453121e-01 0.838 0 0
Interleukin-2 signaling R-HSA-9020558 1.474678e-01 0.831 0 0
NGF-stimulated transcription R-HSA-9031628 1.941150e-01 0.712 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.639871e-01 0.785 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.036596e-01 0.691 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.455990e-01 0.837 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.055210e-01 0.687 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.523008e-01 0.817 0 0
Autophagy R-HSA-9612973 1.907014e-01 0.720 0 0
Signaling by NOTCH1 R-HSA-1980143 1.664049e-01 0.779 0 0
Signaling by LTK R-HSA-9842663 2.036596e-01 0.691 0 0
Eukaryotic Translation Termination R-HSA-72764 2.044842e-01 0.689 0 0
Neurodegenerative Diseases R-HSA-8863678 1.489228e-01 0.827 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.489228e-01 0.827 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.446136e-01 0.840 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.747842e-01 0.757 0 0
TRP channels R-HSA-3295583 1.858008e-01 0.731 0 0
PLC beta mediated events R-HSA-112043 2.065063e-01 0.685 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.055210e-01 0.687 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.603855e-01 0.795 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.144445e-01 0.669 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.144445e-01 0.669 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.455990e-01 0.837 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.095121e-01 0.679 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.696379e-01 0.770 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.930300e-01 0.714 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.036596e-01 0.691 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.714161e-01 0.766 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.036596e-01 0.691 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.639871e-01 0.785 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.671189e-01 0.777 0 0
Interleukin-1 family signaling R-HSA-446652 2.107282e-01 0.676 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.036596e-01 0.691 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.639871e-01 0.785 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.435558e-01 0.843 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.154055e-01 0.667 0 0
Signaling by ERBB4 R-HSA-1236394 2.154055e-01 0.667 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.158815e-01 0.666 0 0
NADE modulates death signalling R-HSA-205025 2.158815e-01 0.666 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.158815e-01 0.666 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.158815e-01 0.666 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.158815e-01 0.666 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.158815e-01 0.666 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.158815e-01 0.666 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.158815e-01 0.666 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.158815e-01 0.666 0 0
Dopamine receptors R-HSA-390651 2.158815e-01 0.666 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.158815e-01 0.666 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.179651e-01 0.662 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.228261e-01 0.652 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.228261e-01 0.652 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.228261e-01 0.652 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.228909e-01 0.652 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.245422e-01 0.649 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.251672e-01 0.647 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.259901e-01 0.646 0 0
HIV elongation arrest and recovery R-HSA-167287 2.259901e-01 0.646 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.259901e-01 0.646 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.259901e-01 0.646 0 0
Cyclin D associated events in G1 R-HSA-69231 2.260781e-01 0.646 0 0
G1 Phase R-HSA-69236 2.260781e-01 0.646 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.270369e-01 0.644 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.270369e-01 0.644 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.271506e-01 0.644 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.512911e-01 0.600 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.512911e-01 0.600 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.512911e-01 0.600 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.512911e-01 0.600 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.512911e-01 0.600 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.512911e-01 0.600 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.512911e-01 0.600 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.512911e-01 0.600 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.521662e-01 0.453 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.521662e-01 0.453 0 0
Mitochondrial transcription initiation R-HSA-163282 3.521662e-01 0.453 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.521662e-01 0.453 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.521662e-01 0.453 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.521662e-01 0.453 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.521662e-01 0.453 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.521662e-01 0.453 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.521662e-01 0.453 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.521662e-01 0.453 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.521662e-01 0.453 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.521662e-01 0.453 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.521662e-01 0.453 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.521662e-01 0.453 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.521662e-01 0.453 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.521662e-01 0.453 0 0
Intestinal infectious diseases R-HSA-8942233 3.521662e-01 0.453 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.521662e-01 0.453 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.521662e-01 0.453 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.521662e-01 0.453 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.521662e-01 0.453 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.521662e-01 0.453 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.521662e-01 0.453 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.521662e-01 0.453 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.521662e-01 0.453 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.689710e-01 0.570 0 0
Activation of AKT2 R-HSA-165158 2.689710e-01 0.570 0 0
IRS activation R-HSA-74713 2.689710e-01 0.570 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.689710e-01 0.570 0 0
G2 Phase R-HSA-68911 2.689710e-01 0.570 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.689710e-01 0.570 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.689710e-01 0.570 0 0
WNT mediated activation of DVL R-HSA-201688 2.523683e-01 0.598 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.523683e-01 0.598 0 0
ALK mutants bind TKIs R-HSA-9700645 2.523683e-01 0.598 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.219924e-01 0.492 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.219924e-01 0.492 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.219924e-01 0.492 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.219924e-01 0.492 0 0
PKB-mediated events R-HSA-109703 3.219924e-01 0.492 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.219924e-01 0.492 0 0
Phosphorylation of Emi1 R-HSA-176417 3.219924e-01 0.492 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.219924e-01 0.492 0 0
PDE3B signalling R-HSA-165160 3.219924e-01 0.492 0 0
DSCAM interactions R-HSA-376172 4.394552e-01 0.357 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.394552e-01 0.357 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.394552e-01 0.357 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.394552e-01 0.357 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.394552e-01 0.357 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.394552e-01 0.357 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.338035e-01 0.631 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.338035e-01 0.631 0 0
Formation of axial mesoderm R-HSA-9796292 2.338035e-01 0.631 0 0
PI3K/AKT activation R-HSA-198203 2.911443e-01 0.536 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.911443e-01 0.536 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.911443e-01 0.536 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.911443e-01 0.536 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.911443e-01 0.536 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.911443e-01 0.536 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.649260e-01 0.577 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.649260e-01 0.577 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.649260e-01 0.577 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.740008e-01 0.427 0 0
PKA activation in glucagon signalling R-HSA-164378 2.424306e-01 0.615 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.302850e-01 0.481 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.302850e-01 0.481 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 3.302850e-01 0.481 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.967448e-01 0.528 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.967448e-01 0.528 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.967448e-01 0.528 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.693263e-01 0.570 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.693263e-01 0.570 0 0
Signaling by Erythropoietin R-HSA-9006335 2.471231e-01 0.607 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.471231e-01 0.607 0 0
Late endosomal microautophagy R-HSA-9615710 2.471231e-01 0.607 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.471231e-01 0.607 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.700396e-01 0.569 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.700396e-01 0.569 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.700396e-01 0.569 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.968232e-01 0.528 0 0
Phosphorylation of the APC/C R-HSA-176412 3.289911e-01 0.483 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.289911e-01 0.483 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.693611e-01 0.433 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.693611e-01 0.433 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.243072e-01 0.372 0 0
Regulation of PTEN localization R-HSA-8948747 4.243072e-01 0.372 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.243072e-01 0.372 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.243072e-01 0.372 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.243072e-01 0.372 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.243072e-01 0.372 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.243072e-01 0.372 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.688315e-01 0.571 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.945099e-01 0.531 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.945099e-01 0.531 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 2.945099e-01 0.531 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.247475e-01 0.488 0 0
HIV Transcription Elongation R-HSA-167169 2.450840e-01 0.611 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.450840e-01 0.611 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.450840e-01 0.611 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.614130e-01 0.442 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.614130e-01 0.442 0 0
Phase 2 - plateau phase R-HSA-5576893 3.614130e-01 0.442 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.614130e-01 0.442 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.193925e-01 0.496 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.080020e-01 0.389 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.602746e-01 0.585 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.529317e-01 0.452 0 0
Voltage gated Potassium channels R-HSA-1296072 3.077063e-01 0.512 0 0
Centrosome maturation R-HSA-380287 2.283748e-01 0.641 0 0
Signaling by KIT in disease R-HSA-9669938 3.812162e-01 0.419 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.812162e-01 0.419 0 0
FGFR2 alternative splicing R-HSA-6803529 3.812162e-01 0.419 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.699164e-01 0.432 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.699164e-01 0.432 0 0
Adenylate cyclase activating pathway R-HSA-170660 4.458945e-01 0.351 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.794265e-01 0.554 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.258801e-01 0.371 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.258801e-01 0.371 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.094514e-01 0.388 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.828322e-01 0.417 0 0
IRS-mediated signalling R-HSA-112399 3.428318e-01 0.465 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.344997e-01 0.476 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.344997e-01 0.476 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.266434e-01 0.486 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.811278e-01 0.551 0 0
PTEN Regulation R-HSA-6807070 2.608681e-01 0.584 0 0
Viral mRNA Translation R-HSA-192823 2.994512e-01 0.524 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.427845e-01 0.465 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.706443e-01 0.431 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.206949e-01 0.376 0 0
Activation of the pre-replicative complex R-HSA-68962 4.206949e-01 0.376 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.374986e-01 0.359 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.374986e-01 0.359 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.896759e-01 0.409 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.147117e-01 0.382 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.293266e-01 0.367 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.333128e-01 0.363 0 0
HCMV Early Events R-HSA-9609690 3.903494e-01 0.409 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.993786e-01 0.399 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.193925e-01 0.496 0 0
G1/S Transition R-HSA-69206 2.988059e-01 0.525 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.665374e-01 0.574 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.665374e-01 0.574 0 0
Specification of the neural plate border R-HSA-9834899 2.693263e-01 0.570 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.614130e-01 0.442 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.365021e-01 0.473 0 0
Signaling by FGFR R-HSA-190236 3.191071e-01 0.496 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.596046e-01 0.444 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.258801e-01 0.371 0 0
Signaling by MET R-HSA-6806834 3.975514e-01 0.401 0 0
Insulin receptor signalling cascade R-HSA-74751 3.514585e-01 0.454 0 0
RNA Polymerase III Transcription R-HSA-74158 4.293266e-01 0.367 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.077063e-01 0.512 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.641641e-01 0.578 0 0
Telomere Maintenance R-HSA-157579 3.058519e-01 0.514 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.927660e-01 0.533 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.693611e-01 0.433 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.614130e-01 0.442 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.628777e-01 0.440 0 0
Activation of GABAB receptors R-HSA-991365 3.018178e-01 0.520 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.454563e-01 0.610 0 0
Aggrephagy R-HSA-9646399 3.715595e-01 0.430 0 0
Signal attenuation R-HSA-74749 2.911443e-01 0.536 0 0
Gap junction trafficking R-HSA-190828 3.412341e-01 0.467 0 0
MHC class II antigen presentation R-HSA-2132295 4.251212e-01 0.371 0 0
GPVI-mediated activation cascade R-HSA-114604 2.869344e-01 0.542 1 1
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.258801e-01 0.371 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.469247e-01 0.350 0 0
GAB1 signalosome R-HSA-180292 2.424306e-01 0.615 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.931225e-01 0.405 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.219924e-01 0.492 0 0
LGI-ADAM interactions R-HSA-5682910 3.302850e-01 0.481 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.243072e-01 0.372 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.427845e-01 0.465 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.122379e-01 0.506 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.787157e-01 0.422 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.465863e-01 0.608 0 0
RNA Polymerase I Transcription R-HSA-73864 2.691063e-01 0.570 0 0
GABA B receptor activation R-HSA-977444 3.018178e-01 0.520 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.523683e-01 0.598 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.740008e-01 0.427 0 0
NADPH regeneration R-HSA-389542 3.740008e-01 0.427 0 0
PKA activation R-HSA-163615 2.424306e-01 0.615 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.289911e-01 0.483 0 0
NF-kB is activated and signals survival R-HSA-209560 3.693611e-01 0.433 0 0
GABA receptor activation R-HSA-977443 2.848105e-01 0.545 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.344997e-01 0.476 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.030315e-01 0.395 0 0
Signaling by PDGF R-HSA-186797 3.177154e-01 0.498 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.622602e-01 0.441 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.193925e-01 0.496 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.956388e-01 0.403 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.416612e-01 0.617 0 0
Interleukin-6 signaling R-HSA-1059683 4.458945e-01 0.351 0 0
Cellular response to chemical stress R-HSA-9711123 3.787483e-01 0.422 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.365021e-01 0.473 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.689710e-01 0.570 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.689710e-01 0.570 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.523683e-01 0.598 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.394552e-01 0.357 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.693611e-01 0.433 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.243072e-01 0.372 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.937792e-01 0.405 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.458945e-01 0.351 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.458945e-01 0.351 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.741925e-01 0.562 0 0
Ca2+ pathway R-HSA-4086398 3.919863e-01 0.407 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.781603e-01 0.422 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.596046e-01 0.444 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.967448e-01 0.528 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.523683e-01 0.598 0 0
DNA Replication R-HSA-69306 4.265078e-01 0.370 0 0
Frs2-mediated activation R-HSA-170968 2.338035e-01 0.631 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.911443e-01 0.536 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.060999e-01 0.391 0 0
Regulated Necrosis R-HSA-5218859 3.106831e-01 0.508 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.219924e-01 0.492 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.289911e-01 0.483 0 0
Signaling by FGFR in disease R-HSA-1226099 4.085444e-01 0.389 0 0
Cardiogenesis R-HSA-9733709 3.365021e-01 0.473 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.459167e-01 0.351 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.324904e-01 0.634 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.689710e-01 0.570 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.953279e-01 0.403 0 0
Signaling by TGFB family members R-HSA-9006936 4.289243e-01 0.368 1 0
Effects of PIP2 hydrolysis R-HSA-114508 3.596046e-01 0.444 0 0
Host Interactions of HIV factors R-HSA-162909 2.762368e-01 0.559 0 0
Cardiac conduction R-HSA-5576891 2.351718e-01 0.629 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.927660e-01 0.533 0 0
Interleukin-7 signaling R-HSA-1266695 2.945099e-01 0.531 0 0
Prolonged ERK activation events R-HSA-169893 3.289911e-01 0.483 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.512911e-01 0.600 0 0
Inhibition of PKR R-HSA-169131 2.512911e-01 0.600 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.521662e-01 0.453 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.521662e-01 0.453 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.521662e-01 0.453 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.689710e-01 0.570 0 0
Unwinding of DNA R-HSA-176974 2.523683e-01 0.598 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.523683e-01 0.598 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.394552e-01 0.357 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.394552e-01 0.357 0 0
C6 deamination of adenosine R-HSA-75102 4.394552e-01 0.357 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.394552e-01 0.357 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.302850e-01 0.481 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 2.700396e-01 0.569 0 0
Negative regulation of FLT3 R-HSA-9706369 3.289911e-01 0.483 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.243072e-01 0.372 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.247475e-01 0.488 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.193925e-01 0.496 0 0
Regulation of IFNG signaling R-HSA-877312 4.080020e-01 0.389 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.077063e-01 0.512 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.011408e-01 0.521 0 0
Amine ligand-binding receptors R-HSA-375280 3.412341e-01 0.467 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.094514e-01 0.388 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.402081e-01 0.468 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.218292e-01 0.375 0 0
Degradation of CDH1 R-HSA-9766229 4.420223e-01 0.355 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.607117e-01 0.443 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.258801e-01 0.371 0 0
HCMV Late Events R-HSA-9610379 3.950403e-01 0.403 0 0
Pexophagy R-HSA-9664873 2.911443e-01 0.536 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.700396e-01 0.569 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.552453e-01 0.593 0 0
FLT3 signaling in disease R-HSA-9682385 2.869344e-01 0.542 0 0
Heme signaling R-HSA-9707616 3.177154e-01 0.498 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.429603e-01 0.614 0 0
Hemostasis R-HSA-109582 4.184360e-01 0.378 1 0
PECAM1 interactions R-HSA-210990 3.302850e-01 0.481 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.665374e-01 0.574 0 0
Formation of the nephric duct R-HSA-9830364 2.945099e-01 0.531 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.549275e-01 0.342 0 0
Ion homeostasis R-HSA-5578775 3.251166e-01 0.488 0 0
Stimuli-sensing channels R-HSA-2672351 3.781603e-01 0.422 0 0
PI Metabolism R-HSA-1483255 2.868343e-01 0.542 0 0
Maturation of nucleoprotein R-HSA-9683610 2.338035e-01 0.631 0 0
Platelet sensitization by LDL R-HSA-432142 2.424306e-01 0.615 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.693611e-01 0.433 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.243072e-01 0.372 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.365021e-01 0.473 0 0
Amyloid fiber formation R-HSA-977225 3.121318e-01 0.506 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.087633e-01 0.389 0 0
Sensory processing of sound R-HSA-9659379 2.832227e-01 0.548 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.529317e-01 0.452 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.247475e-01 0.488 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.219924e-01 0.492 0 0
Maturation of nucleoprotein R-HSA-9694631 2.693263e-01 0.570 0 0
Selenocysteine synthesis R-HSA-2408557 2.744022e-01 0.562 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.219924e-01 0.492 0 0
Co-inhibition by BTLA R-HSA-9927353 2.689710e-01 0.570 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.219924e-01 0.492 0 0
Glucose metabolism R-HSA-70326 3.485523e-01 0.458 0 0
Inositol phosphate metabolism R-HSA-1483249 3.435867e-01 0.464 0 0
Signaling by Leptin R-HSA-2586552 2.911443e-01 0.536 0 0
Specification of primordial germ cells R-HSA-9827857 3.937792e-01 0.405 0 0
Signal regulatory protein family interactions R-HSA-391160 2.649260e-01 0.577 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.270109e-01 0.485 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.258801e-01 0.371 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.458945e-01 0.351 0 0
Integration of energy metabolism R-HSA-163685 4.553810e-01 0.342 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.553810e-01 0.342 0 0
Regulation of signaling by CBL R-HSA-912631 4.575295e-01 0.340 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.575295e-01 0.340 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.575295e-01 0.340 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.575295e-01 0.340 0 0
The NLRP3 inflammasome R-HSA-844456 4.575295e-01 0.340 0 0
Other interleukin signaling R-HSA-449836 4.575295e-01 0.340 0 0
Adaptive Immune System R-HSA-1280218 4.583675e-01 0.339 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.617288e-01 0.336 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.617288e-01 0.336 0 0
Regulation of CDH1 Function R-HSA-9764561 4.659120e-01 0.332 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.724262e-01 0.326 0 0
RSK activation R-HSA-444257 4.724262e-01 0.326 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.724262e-01 0.326 0 0
Regulation by c-FLIP R-HSA-3371378 4.724262e-01 0.326 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.724262e-01 0.326 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.724262e-01 0.326 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.724262e-01 0.326 0 0
Dimerization of procaspase-8 R-HSA-69416 4.724262e-01 0.326 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.724262e-01 0.326 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.724262e-01 0.326 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.724262e-01 0.326 0 0
SLC-mediated bile acid transport R-HSA-9958517 4.724262e-01 0.326 0 0
Interleukin-18 signaling R-HSA-9012546 4.724262e-01 0.326 0 0
MET promotes cell motility R-HSA-8875878 4.753534e-01 0.323 0 0
DAP12 interactions R-HSA-2172127 4.790075e-01 0.320 0 0
Toll-like Receptor Cascades R-HSA-168898 4.798194e-01 0.319 0 0
Ribosome-associated quality control R-HSA-9948299 4.799727e-01 0.319 0 0
HSF1-dependent transactivation R-HSA-3371571 4.821011e-01 0.317 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.827802e-01 0.316 0 0
cGMP effects R-HSA-418457 4.827802e-01 0.316 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.827802e-01 0.316 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.827802e-01 0.316 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.827802e-01 0.316 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.827802e-01 0.316 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.827802e-01 0.316 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.827802e-01 0.316 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.827802e-01 0.316 0 0
rRNA processing R-HSA-72312 4.867395e-01 0.313 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.885640e-01 0.311 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.885640e-01 0.311 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.885640e-01 0.311 0 0
Signal transduction by L1 R-HSA-445144 4.885640e-01 0.311 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.925338e-01 0.308 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.925338e-01 0.308 0 0
G-protein beta:gamma signalling R-HSA-397795 4.955593e-01 0.305 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.955593e-01 0.305 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.960673e-01 0.304 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.987930e-01 0.302 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.987930e-01 0.302 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.012181e-01 0.300 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.012181e-01 0.300 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.018930e-01 0.299 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.107060e-01 0.292 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.107060e-01 0.292 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.107060e-01 0.292 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.149872e-01 0.288 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.149872e-01 0.288 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.149872e-01 0.288 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.149872e-01 0.288 0 0
Classical Kir channels R-HSA-1296053 5.149872e-01 0.288 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.149872e-01 0.288 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.149872e-01 0.288 0 0
MET activates STAT3 R-HSA-8875791 5.149872e-01 0.288 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.149872e-01 0.288 0 0
Intracellular oxygen transport R-HSA-8981607 5.149872e-01 0.288 0 0
Histamine receptors R-HSA-390650 5.149872e-01 0.288 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.149872e-01 0.288 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.180340e-01 0.286 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.180340e-01 0.286 0 0
CASP8 activity is inhibited R-HSA-5218900 5.180340e-01 0.286 0 0
mRNA Editing R-HSA-75072 5.180340e-01 0.286 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.180340e-01 0.286 0 0
Interleukin-1 processing R-HSA-448706 5.180340e-01 0.286 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.180340e-01 0.286 0 0
ARMS-mediated activation R-HSA-170984 5.180340e-01 0.286 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.180340e-01 0.286 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.180340e-01 0.286 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.180340e-01 0.286 0 0
Lipophagy R-HSA-9613354 5.180340e-01 0.286 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.184513e-01 0.285 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.184513e-01 0.285 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.184513e-01 0.285 1 1
p75NTR signals via NF-kB R-HSA-193639 5.184513e-01 0.285 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.184513e-01 0.285 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.188436e-01 0.285 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.188436e-01 0.285 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.188436e-01 0.285 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.188436e-01 0.285 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.188436e-01 0.285 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.193057e-01 0.285 0 0
Cristae formation R-HSA-8949613 5.193057e-01 0.285 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.203539e-01 0.284 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.203539e-01 0.284 0 0
Diseases of Immune System R-HSA-5260271 5.203539e-01 0.284 0 0
Generation of second messenger molecules R-HSA-202433 5.203539e-01 0.284 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.209053e-01 0.283 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.214619e-01 0.283 0 0
Signaling by NOTCH4 R-HSA-9013694 5.231197e-01 0.281 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.257531e-01 0.279 0 0
Signaling by NOTCH2 R-HSA-1980145 5.436007e-01 0.265 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.454573e-01 0.263 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.454573e-01 0.263 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.482501e-01 0.261 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.527461e-01 0.257 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.527461e-01 0.257 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.527461e-01 0.257 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.527461e-01 0.257 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.527461e-01 0.257 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.527461e-01 0.257 0 0
Differentiation of T cells R-HSA-9945266 5.527461e-01 0.257 0 0
Adipogenesis R-HSA-9843745 5.527691e-01 0.257 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.583495e-01 0.253 0 0
Signaling by NOTCH3 R-HSA-9012852 5.597740e-01 0.252 0 0
Binding and entry of HIV virion R-HSA-173107 5.609339e-01 0.251 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.609339e-01 0.251 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.609339e-01 0.251 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.638530e-01 0.249 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.638976e-01 0.249 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.651355e-01 0.248 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.680598e-01 0.246 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.689353e-01 0.245 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.709118e-01 0.243 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.709118e-01 0.243 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.711312e-01 0.243 0 0
Neutrophil degranulation R-HSA-6798695 5.732309e-01 0.242 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.766868e-01 0.239 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.766868e-01 0.239 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.803453e-01 0.236 0 0
Nucleotide catabolism defects R-HSA-9735786 5.803453e-01 0.236 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.803453e-01 0.236 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.803453e-01 0.236 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.803453e-01 0.236 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.803453e-01 0.236 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.803453e-01 0.236 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.803453e-01 0.236 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.803453e-01 0.236 0 0
DNA Damage Bypass R-HSA-73893 5.813235e-01 0.236 0 0
Potassium Channels R-HSA-1296071 5.833290e-01 0.234 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.855440e-01 0.232 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.855440e-01 0.232 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.855440e-01 0.232 0 0
Passive transport by Aquaporins R-HSA-432047 5.855440e-01 0.232 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.855440e-01 0.232 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.855440e-01 0.232 0 0
G1/S-Specific Transcription R-HSA-69205 5.895129e-01 0.230 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.908202e-01 0.229 0 0
Hedgehog 'on' state R-HSA-5632684 5.908202e-01 0.229 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.956044e-01 0.225 0 0
PI3K Cascade R-HSA-109704 6.006552e-01 0.221 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.006552e-01 0.221 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.010274e-01 0.221 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.010274e-01 0.221 0 0
Formation of the posterior neural plate R-HSA-9832991 6.010274e-01 0.221 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.010274e-01 0.221 0 0
Suppression of apoptosis R-HSA-9635465 6.010274e-01 0.221 0 0
Prostanoid ligand receptors R-HSA-391908 6.010274e-01 0.221 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.040763e-01 0.219 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.115399e-01 0.214 0 0
Cilium Assembly R-HSA-5617833 6.147075e-01 0.211 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.167610e-01 0.210 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.167610e-01 0.210 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.167610e-01 0.210 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.167610e-01 0.210 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.167610e-01 0.210 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.167610e-01 0.210 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.167610e-01 0.210 0 0
SARS-CoV Infections R-HSA-9679506 6.185060e-01 0.209 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.233485e-01 0.205 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.328933e-01 0.199 0 0
Activation of AMPA receptors R-HSA-399710 6.368993e-01 0.196 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.368993e-01 0.196 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.368993e-01 0.196 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.368993e-01 0.196 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.368993e-01 0.196 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.368993e-01 0.196 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.368993e-01 0.196 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.368993e-01 0.196 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.368993e-01 0.196 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.368993e-01 0.196 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.368993e-01 0.196 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.368993e-01 0.196 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.379151e-01 0.195 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.379151e-01 0.195 0 0
ERKs are inactivated R-HSA-202670 6.382919e-01 0.195 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.382919e-01 0.195 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.382919e-01 0.195 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.382919e-01 0.195 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.382919e-01 0.195 0 0
Integration of provirus R-HSA-162592 6.382919e-01 0.195 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.382919e-01 0.195 0 0
Hedgehog 'off' state R-HSA-5610787 6.387816e-01 0.195 0 0
Cellular response to starvation R-HSA-9711097 6.419979e-01 0.192 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.425015e-01 0.192 0 0
DNA strand elongation R-HSA-69190 6.425015e-01 0.192 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.448844e-01 0.191 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.448844e-01 0.191 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.463445e-01 0.190 0 0
Mismatch Repair R-HSA-5358508 6.463445e-01 0.190 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.463445e-01 0.190 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.463445e-01 0.190 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.463445e-01 0.190 0 0
Circadian clock R-HSA-9909396 6.501542e-01 0.187 0 0
HCMV Infection R-HSA-9609646 6.526297e-01 0.185 0 0
Stabilization of p53 R-HSA-69541 6.535411e-01 0.185 0 0
Tight junction interactions R-HSA-420029 6.554943e-01 0.183 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.554943e-01 0.183 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.557935e-01 0.183 0 0
Smooth Muscle Contraction R-HSA-445355 6.557935e-01 0.183 0 0
Vesicle-mediated transport R-HSA-5653656 6.574924e-01 0.182 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.614981e-01 0.179 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.641800e-01 0.178 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.658407e-01 0.177 0 0
MAP kinase activation R-HSA-450294 6.658407e-01 0.177 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.727616e-01 0.172 0 0
Interleukin-15 signaling R-HSA-8983432 6.727616e-01 0.172 0 0
Estrogen biosynthesis R-HSA-193144 6.727616e-01 0.172 0 0
OAS antiviral response R-HSA-8983711 6.727616e-01 0.172 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.734584e-01 0.172 0 0
Interleukin-2 family signaling R-HSA-451927 6.734584e-01 0.172 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.734584e-01 0.172 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.734584e-01 0.172 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.739321e-01 0.171 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.742691e-01 0.171 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.742691e-01 0.171 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.742691e-01 0.171 0 0
Ion channel transport R-HSA-983712 6.747163e-01 0.171 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.819003e-01 0.166 0 0
TRAIL signaling R-HSA-75158 6.858347e-01 0.164 0 0
Plus-strand DNA synthesis R-HSA-164525 6.858347e-01 0.164 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.858347e-01 0.164 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.858347e-01 0.164 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.858347e-01 0.164 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.858347e-01 0.164 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.858347e-01 0.164 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.858347e-01 0.164 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.858347e-01 0.164 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.858347e-01 0.164 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.858347e-01 0.164 0 0
Ceramide signalling R-HSA-193681 6.858347e-01 0.164 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.858347e-01 0.164 0 0
Synthesis of PS R-HSA-1483101 6.858347e-01 0.164 0 0
Formation of the Editosome R-HSA-75094 6.858347e-01 0.164 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.858347e-01 0.164 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.858347e-01 0.164 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.858347e-01 0.164 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.858347e-01 0.164 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.858347e-01 0.164 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.858469e-01 0.164 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.858469e-01 0.164 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.921439e-01 0.160 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.926264e-01 0.160 0 0
GPCR downstream signalling R-HSA-388396 6.979612e-01 0.156 0 0
PCP/CE pathway R-HSA-4086400 6.981379e-01 0.156 0 0
IRE1alpha activates chaperones R-HSA-381070 6.999214e-01 0.155 0 0
Negative regulation of MET activity R-HSA-6807004 7.005320e-01 0.155 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.005320e-01 0.155 0 0
Signaling by NODAL R-HSA-1181150 7.005320e-01 0.155 0 0
Protein hydroxylation R-HSA-9629569 7.005320e-01 0.155 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.022214e-01 0.154 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.022214e-01 0.154 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.022214e-01 0.154 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.045130e-01 0.152 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.045130e-01 0.152 0 0
Chylomicron remodeling R-HSA-8963901 7.045130e-01 0.152 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.045130e-01 0.152 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.045130e-01 0.152 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.045130e-01 0.152 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.045130e-01 0.152 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.045130e-01 0.152 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.045130e-01 0.152 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.055886e-01 0.151 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.061351e-01 0.151 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.061351e-01 0.151 0 0
TNF signaling R-HSA-75893 7.062010e-01 0.151 0 0
Regulation of insulin secretion R-HSA-422356 7.073029e-01 0.150 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.089787e-01 0.149 0 0
G alpha (s) signalling events R-HSA-418555 7.097955e-01 0.149 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.110323e-01 0.148 0 0
HIV Transcription Initiation R-HSA-167161 7.110323e-01 0.148 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.110323e-01 0.148 0 0
Ion transport by P-type ATPases R-HSA-936837 7.127830e-01 0.147 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.163714e-01 0.145 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.186651e-01 0.143 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.191768e-01 0.143 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.191768e-01 0.143 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.210414e-01 0.142 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.237972e-01 0.140 0 0
Inflammasomes R-HSA-622312 7.237972e-01 0.140 0 0
ERK/MAPK targets R-HSA-198753 7.251496e-01 0.140 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.251496e-01 0.140 0 0
Signaling by Hedgehog R-HSA-5358351 7.256186e-01 0.139 0 0
Signaling by LTK in cancer R-HSA-9842640 7.281775e-01 0.138 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.281775e-01 0.138 0 0
STAT5 Activation R-HSA-9645135 7.281775e-01 0.138 0 0
Uncoating of the HIV Virion R-HSA-162585 7.281775e-01 0.138 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.281775e-01 0.138 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.281775e-01 0.138 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.281775e-01 0.138 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.281775e-01 0.138 0 0
MET Receptor Activation R-HSA-6806942 7.281775e-01 0.138 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.281775e-01 0.138 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.281775e-01 0.138 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.281775e-01 0.138 0 0
Abacavir transmembrane transport R-HSA-2161517 7.281775e-01 0.138 0 0
Lipid particle organization R-HSA-8964572 7.281775e-01 0.138 0 0
Nef and signal transduction R-HSA-164944 7.281775e-01 0.138 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.281775e-01 0.138 0 0
Neurofascin interactions R-HSA-447043 7.281775e-01 0.138 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.286687e-01 0.137 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.329482e-01 0.135 0 0
Removal of the Flap Intermediate R-HSA-69166 7.336525e-01 0.135 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.336525e-01 0.135 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.336525e-01 0.135 0 0
HDL assembly R-HSA-8963896 7.336525e-01 0.135 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.336525e-01 0.135 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.370548e-01 0.133 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.395379e-01 0.131 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.439070e-01 0.128 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.439070e-01 0.128 0 0
mRNA Capping R-HSA-72086 7.441879e-01 0.128 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.441879e-01 0.128 0 0
Platelet calcium homeostasis R-HSA-418360 7.441879e-01 0.128 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.455332e-01 0.128 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.481540e-01 0.126 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.488887e-01 0.126 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.534687e-01 0.123 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.546962e-01 0.122 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.591201e-01 0.120 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.603074e-01 0.119 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.603074e-01 0.119 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.603074e-01 0.119 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.603074e-01 0.119 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.603074e-01 0.119 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.603074e-01 0.119 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.603074e-01 0.119 0 0
Formation of the anterior neural plate R-HSA-9823739 7.603074e-01 0.119 0 0
Protein methylation R-HSA-8876725 7.603074e-01 0.119 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.631672e-01 0.117 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.634099e-01 0.117 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.634099e-01 0.117 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.648155e-01 0.116 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.648155e-01 0.116 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.648155e-01 0.116 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.648155e-01 0.116 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.648155e-01 0.116 0 0
Recycling of eIF2:GDP R-HSA-72731 7.648155e-01 0.116 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.648155e-01 0.116 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.648155e-01 0.116 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.648155e-01 0.116 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.648155e-01 0.116 0 0
VLDL clearance R-HSA-8964046 7.648155e-01 0.116 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.648155e-01 0.116 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.695893e-01 0.114 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.695893e-01 0.114 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.695893e-01 0.114 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.695893e-01 0.114 0 0
Selenoamino acid metabolism R-HSA-2408522 7.696505e-01 0.114 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.712708e-01 0.113 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.769586e-01 0.110 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.769586e-01 0.110 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.769586e-01 0.110 0 0
Leishmania infection R-HSA-9658195 7.773193e-01 0.109 0 0
Parasitic Infection Pathways R-HSA-9824443 7.773193e-01 0.109 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.774535e-01 0.109 0 0
Aquaporin-mediated transport R-HSA-445717 7.789012e-01 0.109 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.814870e-01 0.107 0 0
Budding and maturation of HIV virion R-HSA-162588 7.814870e-01 0.107 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.814870e-01 0.107 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.846179e-01 0.105 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.846179e-01 0.105 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.846179e-01 0.105 0 0
Killing mechanisms R-HSA-9664420 7.846179e-01 0.105 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.846179e-01 0.105 0 0
Atorvastatin ADME R-HSA-9754706 7.846179e-01 0.105 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.846179e-01 0.105 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.846179e-01 0.105 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.895096e-01 0.103 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.895096e-01 0.103 0 0
Syndecan interactions R-HSA-3000170 7.895096e-01 0.103 0 0
Growth hormone receptor signaling R-HSA-982772 7.895096e-01 0.103 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.915352e-01 0.102 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.915352e-01 0.102 0 0
Mitochondrial protein import R-HSA-1268020 7.917264e-01 0.101 0 0
Interleukin-17 signaling R-HSA-448424 7.930846e-01 0.101 0 0
RAS processing R-HSA-9648002 7.936424e-01 0.100 0 0
Nucleotide Excision Repair R-HSA-5696398 7.953809e-01 0.099 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.965170e-01 0.099 0 0
Minus-strand DNA synthesis R-HSA-164516 7.965170e-01 0.099 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.965170e-01 0.099 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.965170e-01 0.099 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.965170e-01 0.099 0 0
MET receptor recycling R-HSA-8875656 7.965170e-01 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.965170e-01 0.099 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.965170e-01 0.099 0 0
Interleukin-9 signaling R-HSA-8985947 7.965170e-01 0.099 0 0
Alpha-defensins R-HSA-1462054 7.965170e-01 0.099 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.984489e-01 0.098 0 0
Signaling by Insulin receptor R-HSA-74752 7.995809e-01 0.097 0 0
Developmental Cell Lineages R-HSA-9734767 8.031057e-01 0.095 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.032095e-01 0.095 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.039895e-01 0.095 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.046963e-01 0.094 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.046963e-01 0.094 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.053704e-01 0.094 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.053704e-01 0.094 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.067317e-01 0.093 0 0
Synthesis of PG R-HSA-1483148 8.067317e-01 0.093 0 0
Interleukin-6 family signaling R-HSA-6783589 8.079762e-01 0.093 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.079762e-01 0.093 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.079762e-01 0.093 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.084342e-01 0.092 0 0
Glycogen metabolism R-HSA-8982491 8.084342e-01 0.092 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.084342e-01 0.092 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.096158e-01 0.092 0 0
Leishmania phagocytosis R-HSA-9664417 8.113300e-01 0.091 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.113300e-01 0.091 0 0
Parasite infection R-HSA-9664407 8.113300e-01 0.091 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.143303e-01 0.089 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.143303e-01 0.089 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.164600e-01 0.088 0 0
PKR-mediated signaling R-HSA-9833482 8.165529e-01 0.088 0 0
Interleukin-21 signaling R-HSA-9020958 8.239469e-01 0.084 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.239469e-01 0.084 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.239469e-01 0.084 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.239469e-01 0.084 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.239469e-01 0.084 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.239469e-01 0.084 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.250558e-01 0.084 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.250558e-01 0.084 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.267992e-01 0.083 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.267992e-01 0.083 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.267992e-01 0.083 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.267992e-01 0.083 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.267992e-01 0.083 0 0
Cellular response to hypoxia R-HSA-1234174 8.268630e-01 0.083 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.291698e-01 0.081 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.291698e-01 0.081 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.354730e-01 0.078 0 0
Translation of Structural Proteins R-HSA-9683701 8.354730e-01 0.078 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.393663e-01 0.076 0 0
TCR signaling R-HSA-202403 8.398330e-01 0.076 0 0
MET activates PTK2 signaling R-HSA-8874081 8.408184e-01 0.075 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.408184e-01 0.075 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.408184e-01 0.075 0 0
Dual Incision in GG-NER R-HSA-5696400 8.430091e-01 0.074 0 0
Gap junction assembly R-HSA-190861 8.430091e-01 0.074 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.430091e-01 0.074 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.430091e-01 0.074 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.449700e-01 0.073 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.449700e-01 0.073 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.449700e-01 0.073 0 0
Viral Infection Pathways R-HSA-9824446 8.451101e-01 0.073 0 0
Immune System R-HSA-168256 8.460348e-01 0.073 0 0
Protein ubiquitination R-HSA-8852135 8.462740e-01 0.072 0 0
2-LTR circle formation R-HSA-164843 8.476806e-01 0.072 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.476806e-01 0.072 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.476806e-01 0.072 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.476806e-01 0.072 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.476806e-01 0.072 0 0
Interleukin-27 signaling R-HSA-9020956 8.476806e-01 0.072 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.476806e-01 0.072 0 0
Arachidonate production from DAG R-HSA-426048 8.476806e-01 0.072 0 0
Maturation of spike protein R-HSA-9683686 8.476806e-01 0.072 0 0
Formation of apoptosome R-HSA-111458 8.476806e-01 0.072 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.476806e-01 0.072 0 0
Josephin domain DUBs R-HSA-5689877 8.476806e-01 0.072 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.476806e-01 0.072 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.476806e-01 0.072 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.476806e-01 0.072 0 0
Regulation of beta-cell development R-HSA-186712 8.499332e-01 0.071 0 0
G alpha (q) signalling events R-HSA-416476 8.510109e-01 0.070 0 0
The phototransduction cascade R-HSA-2514856 8.536398e-01 0.069 0 0
Interferon Signaling R-HSA-913531 8.547658e-01 0.068 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.553361e-01 0.068 0 0
PERK regulates gene expression R-HSA-381042 8.558918e-01 0.068 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.613908e-01 0.065 0 0
Translesion Synthesis by POLH R-HSA-110320 8.613908e-01 0.065 0 0
Translation of Structural Proteins R-HSA-9694635 8.642736e-01 0.063 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.682159e-01 0.061 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.682159e-01 0.061 0 0
Synthesis of PI R-HSA-1483226 8.682159e-01 0.061 0 0
Bicarbonate transporters R-HSA-425381 8.682159e-01 0.061 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.682159e-01 0.061 0 0
Transport of RCbl within the body R-HSA-9758890 8.682159e-01 0.061 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.682159e-01 0.061 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.682159e-01 0.061 0 0
Chylomicron assembly R-HSA-8963888 8.682159e-01 0.061 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.682159e-01 0.061 0 0
Telomere Extension By Telomerase R-HSA-171319 8.686817e-01 0.061 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.686817e-01 0.061 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.686817e-01 0.061 0 0
Platelet homeostasis R-HSA-418346 8.695717e-01 0.061 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.762032e-01 0.057 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.762032e-01 0.057 0 0
Glycogen synthesis R-HSA-3322077 8.762032e-01 0.057 0 0
Nephrin family interactions R-HSA-373753 8.762032e-01 0.057 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.762032e-01 0.057 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.774651e-01 0.057 0 0
Degradation of DVL R-HSA-4641258 8.789688e-01 0.056 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.805358e-01 0.055 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.809280e-01 0.055 0 0
DS-GAG biosynthesis R-HSA-2022923 8.859838e-01 0.053 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.859838e-01 0.053 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.859838e-01 0.053 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.859838e-01 0.053 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.859838e-01 0.053 0 0
Sodium/Calcium exchangers R-HSA-425561 8.859838e-01 0.053 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.892552e-01 0.051 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.892552e-01 0.051 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.895421e-01 0.051 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.895421e-01 0.051 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.895421e-01 0.051 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.895421e-01 0.051 0 0
Lagging Strand Synthesis R-HSA-69186 8.895421e-01 0.051 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.895421e-01 0.051 0 0
Basigin interactions R-HSA-210991 8.895421e-01 0.051 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.895421e-01 0.051 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.895792e-01 0.051 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.895792e-01 0.051 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.916213e-01 0.050 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.921465e-01 0.050 0 0
Signaling by GPCR R-HSA-372790 8.931307e-01 0.049 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.946117e-01 0.048 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.987681e-01 0.046 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.996887e-01 0.046 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 9.013569e-01 0.045 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.013569e-01 0.045 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.013569e-01 0.045 0 0
Interleukin-35 Signalling R-HSA-8984722 9.013569e-01 0.045 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.013569e-01 0.045 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.013569e-01 0.045 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.013569e-01 0.045 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.013569e-01 0.045 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.013569e-01 0.045 0 0
Polymerase switching R-HSA-69091 9.013569e-01 0.045 0 0
Leading Strand Synthesis R-HSA-69109 9.013569e-01 0.045 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.013569e-01 0.045 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.013569e-01 0.045 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.015357e-01 0.045 0 0
Assembly Of The HIV Virion R-HSA-175474 9.015357e-01 0.045 0 0
Cargo concentration in the ER R-HSA-5694530 9.024070e-01 0.045 0 0
Neurotransmitter release cycle R-HSA-112310 9.057918e-01 0.043 0 0
Intraflagellar transport R-HSA-5620924 9.064939e-01 0.043 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.075529e-01 0.042 0 0
Attenuation phase R-HSA-3371568 9.075529e-01 0.042 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.123041e-01 0.040 0 0
Free fatty acid receptors R-HSA-444209 9.123041e-01 0.040 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.123041e-01 0.040 0 0
LDL clearance R-HSA-8964038 9.123041e-01 0.040 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.123041e-01 0.040 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.146581e-01 0.039 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.146581e-01 0.039 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.146581e-01 0.039 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.146581e-01 0.039 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.146581e-01 0.039 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.146581e-01 0.039 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.146581e-01 0.039 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.146581e-01 0.039 0 0
Platelet degranulation R-HSA-114608 9.155740e-01 0.038 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.156540e-01 0.038 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.156540e-01 0.038 0 0
Maturation of spike protein R-HSA-9694548 9.156540e-01 0.038 0 0
Extension of Telomeres R-HSA-180786 9.208650e-01 0.036 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.219596e-01 0.035 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.219596e-01 0.035 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.219596e-01 0.035 0 0
Interleukin-20 family signaling R-HSA-8854691 9.219596e-01 0.035 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.219596e-01 0.035 0 0
Biosynthesis of maresins R-HSA-9018682 9.219596e-01 0.035 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.219596e-01 0.035 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.231146e-01 0.035 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.231146e-01 0.035 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.231146e-01 0.035 0 0
Intra-Golgi traffic R-HSA-6811438 9.231146e-01 0.035 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.231146e-01 0.035 0 0
Synthesis of DNA R-HSA-69239 9.235605e-01 0.035 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.261663e-01 0.033 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.261663e-01 0.033 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.261663e-01 0.033 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.261663e-01 0.033 0 0
Physiological factors R-HSA-5578768 9.261663e-01 0.033 0 0
Prolactin receptor signaling R-HSA-1170546 9.261663e-01 0.033 0 0
Malate-aspartate shuttle R-HSA-9856872 9.261663e-01 0.033 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.261663e-01 0.033 0 0
Zinc transporters R-HSA-435354 9.261663e-01 0.033 0 0
P2Y receptors R-HSA-417957 9.261663e-01 0.033 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.299765e-01 0.032 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.299765e-01 0.032 0 0
Interleukin-1 signaling R-HSA-9020702 9.300328e-01 0.032 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.306065e-01 0.031 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.306065e-01 0.031 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.306065e-01 0.031 0 0
Complex III assembly R-HSA-9865881 9.306065e-01 0.031 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.306065e-01 0.031 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.336471e-01 0.030 0 0
Orc1 removal from chromatin R-HSA-68949 9.336471e-01 0.030 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.351815e-01 0.029 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.351815e-01 0.029 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.351815e-01 0.029 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.361233e-01 0.029 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.361233e-01 0.029 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.361233e-01 0.029 0 0
Translesion synthesis by REV1 R-HSA-110312 9.361233e-01 0.029 0 0
Signaling by Activin R-HSA-1502540 9.361233e-01 0.029 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.361233e-01 0.029 0 0
Other semaphorin interactions R-HSA-416700 9.361233e-01 0.029 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.362800e-01 0.029 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.362800e-01 0.029 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.380192e-01 0.028 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.380192e-01 0.028 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.383412e-01 0.028 0 0
G protein gated Potassium channels R-HSA-1296059 9.383412e-01 0.028 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.383412e-01 0.028 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.383412e-01 0.028 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.383412e-01 0.028 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.383412e-01 0.028 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.392254e-01 0.027 0 0
Regulation of Apoptosis R-HSA-169911 9.416106e-01 0.026 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.420636e-01 0.026 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.443781e-01 0.025 0 0
Translesion synthesis by POLI R-HSA-5656121 9.447380e-01 0.025 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.447380e-01 0.025 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.447380e-01 0.025 0 0
Fructose catabolism R-HSA-70350 9.447380e-01 0.025 0 0
Attachment and Entry R-HSA-9678110 9.447380e-01 0.025 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.452523e-01 0.024 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.473888e-01 0.023 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.474440e-01 0.023 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.474440e-01 0.023 0 0
HSF1 activation R-HSA-3371511 9.474440e-01 0.023 0 0
Triglyceride catabolism R-HSA-163560 9.474440e-01 0.023 0 0
Gastrulation R-HSA-9758941 9.480989e-01 0.023 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.514213e-01 0.022 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.514213e-01 0.022 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.514213e-01 0.022 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.514213e-01 0.022 0 0
Translesion synthesis by POLK R-HSA-5655862 9.521913e-01 0.021 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.521913e-01 0.021 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.521913e-01 0.021 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.521913e-01 0.021 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.521913e-01 0.021 0 0
Fibronectin matrix formation R-HSA-1566977 9.521913e-01 0.021 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.521913e-01 0.021 0 0
Galactose catabolism R-HSA-70370 9.521913e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.521913e-01 0.021 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.522169e-01 0.021 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.522169e-01 0.021 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.527308e-01 0.021 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.527308e-01 0.021 0 0
NCAM1 interactions R-HSA-419037 9.527308e-01 0.021 0 0
Interferon gamma signaling R-HSA-877300 9.529936e-01 0.021 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.548134e-01 0.020 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.563792e-01 0.019 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.566547e-01 0.019 0 0
Synthesis of PC R-HSA-1483191 9.566547e-01 0.019 0 0
Prednisone ADME R-HSA-9757110 9.569227e-01 0.019 0 0
Synthesis of PA R-HSA-1483166 9.575513e-01 0.019 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.580550e-01 0.019 0 0
ABC-family proteins mediated transport R-HSA-382556 9.584887e-01 0.018 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.586397e-01 0.018 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.586397e-01 0.018 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.586397e-01 0.018 0 0
Glycogen storage diseases R-HSA-3229121 9.586397e-01 0.018 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.586397e-01 0.018 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.586397e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.586397e-01 0.018 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.586397e-01 0.018 0 0
Protein localization R-HSA-9609507 9.588711e-01 0.018 0 0
Kidney development R-HSA-9830369 9.593569e-01 0.018 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.612032e-01 0.017 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.618462e-01 0.017 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.618462e-01 0.017 0 0
tRNA processing R-HSA-72306 9.619636e-01 0.017 0 0
PPARA activates gene expression R-HSA-1989781 9.634841e-01 0.016 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.642187e-01 0.016 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.642187e-01 0.016 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.642187e-01 0.016 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.642187e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.661875e-01 0.015 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.661875e-01 0.015 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.668013e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.674725e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.690454e-01 0.014 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.690454e-01 0.014 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.690454e-01 0.014 0 0
Methionine salvage pathway R-HSA-1237112 9.690454e-01 0.014 0 0
HDL remodeling R-HSA-8964058 9.690454e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.690454e-01 0.014 0 0
Phospholipid metabolism R-HSA-1483257 9.692560e-01 0.014 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.692885e-01 0.014 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.700687e-01 0.013 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.700687e-01 0.013 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.700687e-01 0.013 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.700687e-01 0.013 0 0
Potential therapeutics for SARS R-HSA-9679191 9.704728e-01 0.013 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.708568e-01 0.013 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.708568e-01 0.013 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.724729e-01 0.012 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.732213e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.732213e-01 0.012 0 0
Keratan sulfate degradation R-HSA-2022857 9.732213e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.732213e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.732213e-01 0.012 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.753424e-01 0.011 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.753424e-01 0.011 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.754656e-01 0.011 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.760964e-01 0.011 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.765823e-01 0.010 0 0
G-protein activation R-HSA-202040 9.768341e-01 0.010 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.768341e-01 0.010 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.768341e-01 0.010 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.779261e-01 0.010 0 0
Interferon alpha/beta signaling R-HSA-909733 9.786320e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.793017e-01 0.009 0 0
Heme degradation R-HSA-189483 9.793017e-01 0.009 0 0
Protein folding R-HSA-391251 9.796176e-01 0.009 0 0
CS-GAG biosynthesis R-HSA-2022870 9.799596e-01 0.009 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.799596e-01 0.009 0 0
Glutathione synthesis and recycling R-HSA-174403 9.799596e-01 0.009 0 0
Attachment and Entry R-HSA-9694614 9.799596e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.799596e-01 0.009 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.800090e-01 0.009 0 0
Surfactant metabolism R-HSA-5683826 9.802505e-01 0.009 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.806087e-01 0.009 0 0
eNOS activation R-HSA-203615 9.817138e-01 0.008 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.817138e-01 0.008 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.817138e-01 0.008 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.823401e-01 0.008 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.823401e-01 0.008 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.826636e-01 0.008 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.826636e-01 0.008 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.826636e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.826636e-01 0.008 0 0
Ethanol oxidation R-HSA-71384 9.826636e-01 0.008 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.838520e-01 0.007 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.838520e-01 0.007 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.844231e-01 0.007 0 0
ABC transporter disorders R-HSA-5619084 9.848283e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.850029e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.850029e-01 0.007 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.850029e-01 0.007 0 0
Carnitine shuttle R-HSA-200425 9.850029e-01 0.007 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.850301e-01 0.007 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.853696e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.857462e-01 0.006 0 0
Dual incision in TC-NER R-HSA-6782135 9.858023e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.870266e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.870266e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.872176e-01 0.006 0 0
Triglyceride metabolism R-HSA-8979227 9.872176e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.874137e-01 0.006 0 0
Degradation of AXIN R-HSA-4641257 9.874234e-01 0.005 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.874234e-01 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 9.874536e-01 0.005 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.887774e-01 0.005 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.887774e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.888712e-01 0.005 0 0
Purine salvage R-HSA-74217 9.889077e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.889077e-01 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.889077e-01 0.005 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.889077e-01 0.005 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.896553e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.899748e-01 0.004 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.902205e-01 0.004 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.902205e-01 0.004 0 0
Urea cycle R-HSA-70635 9.902919e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.902919e-01 0.004 0 0
SLC transporter disorders R-HSA-5619102 9.904361e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.910697e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.912666e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.913810e-01 0.004 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.916022e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.916022e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.916022e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.916022e-01 0.004 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.920423e-01 0.003 0 0
Neddylation R-HSA-8951664 9.923375e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.924066e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.927345e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.927357e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.929122e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.934980e-01 0.003 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.935521e-01 0.003 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.936734e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.937162e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.937162e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.937162e-01 0.003 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.937162e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.937162e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.939266e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.939570e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.941786e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.941786e-01 0.003 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.944931e-01 0.002 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.945058e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.945252e-01 0.002 0 0
Mucopolysaccharidoses R-HSA-2206281 9.945645e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.950043e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.952983e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.952983e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.959330e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.959330e-01 0.002 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.959892e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.959892e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.964731e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.964821e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.964821e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.964914e-01 0.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.967460e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.968758e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.968836e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.968836e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.968994e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.968994e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.969571e-01 0.001 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.969571e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.969571e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.969571e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.972329e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972329e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.972750e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.972750e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.973680e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.973680e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.973680e-01 0.001 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.977234e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.977234e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.977657e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.978967e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.979378e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.980308e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.981529e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.981734e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.982968e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.982968e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.984073e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.984073e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.984349e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984904e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.986135e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.986536e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986536e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.986645e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.987258e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.987258e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.988072e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.990468e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.990468e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990647e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991567e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.991721e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.991755e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.991959e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.992674e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.993778e-01 0.000 0 0
Defensins R-HSA-1461973 9.993833e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.994229e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.994268e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.994318e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.994666e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.994666e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.994666e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994932e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.994956e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995020e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.995387e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.995387e-01 0.000 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.995610e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996178e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.996502e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996502e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996652e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996652e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.996684e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997419e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997419e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997591e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997753e-01 0.000 0 0
Translation R-HSA-72766 9.998375e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998449e-01 0.000 0 0
Disease R-HSA-1643685 9.998552e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.998556e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998622e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998682e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998682e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998864e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998864e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998915e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998920e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998920e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998992e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999038e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999066e-01 0.000 0 0
Digestion R-HSA-8935690 9.999066e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999134e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999303e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999396e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999396e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999406e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999478e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999478e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999527e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999656e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999662e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999746e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999747e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999752e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999766e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999771e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999776e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999801e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999811e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999812e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999878e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999878e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999884e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999894e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999911e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999921e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999949e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999949e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999967e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999984e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999990e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999991e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999996e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Eukaryotic Translation Elongation R-HSA-156842 1.110223e-16 15.955 0 0
Peptide chain elongation R-HSA-156902 1.110223e-16 15.955 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.110223e-16 15.955 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.220446e-16 15.654 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.220446e-16 15.654 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.440892e-16 15.353 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.551115e-16 15.256 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.110223e-15 14.955 0 0
Cell Cycle R-HSA-1640170 1.887379e-15 14.724 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.331468e-15 14.632 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.884182e-15 14.230 0 0
Influenza Infection R-HSA-168255 6.661338e-15 14.176 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.660539e-15 14.116 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.660539e-15 14.116 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.498801e-14 13.824 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.042011e-14 13.517 0 0
Signaling by ROBO receptors R-HSA-376176 3.597123e-14 13.444 0 0
Eukaryotic Translation Termination R-HSA-72764 3.452794e-14 13.462 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.319567e-14 13.479 0 0
Metabolism of RNA R-HSA-8953854 1.419975e-13 12.848 0 0
Selenocysteine synthesis R-HSA-2408557 2.154943e-13 12.667 0 0
Viral mRNA Translation R-HSA-192823 3.856915e-13 12.414 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.146683e-13 12.382 0 0
Cell Cycle, Mitotic R-HSA-69278 4.202194e-13 12.377 0 0
M Phase R-HSA-68886 9.878764e-13 12.005 0 0
Cell Cycle Checkpoints R-HSA-69620 1.904921e-12 11.720 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.172085e-12 11.286 0 0
Ribosome-associated quality control R-HSA-9948299 6.326828e-12 11.199 0 0
rRNA processing R-HSA-72312 2.441580e-11 10.612 0 0
Cellular responses to stimuli R-HSA-8953897 2.615164e-11 10.583 0 0
Cellular responses to stress R-HSA-2262752 9.907319e-11 10.004 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.616388e-10 9.791 0 0
Signal Transduction R-HSA-162582 2.155470e-10 9.666 1 0
Apoptotic execution phase R-HSA-75153 2.693931e-10 9.570 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.512080e-10 9.346 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.560898e-10 9.183 0 0
Mitotic Prophase R-HSA-68875 6.907603e-10 9.161 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.081571e-10 9.042 0 0
Translation initiation complex formation R-HSA-72649 1.041347e-09 8.982 0 0
Cellular response to starvation R-HSA-9711097 1.303851e-09 8.885 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.019550e-09 8.695 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.540633e-09 8.451 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.735937e-09 8.428 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.792314e-09 8.421 0 0
Mitotic Prometaphase R-HSA-68877 3.945134e-09 8.404 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.872705e-09 8.231 0 0
Cellular response to heat stress R-HSA-3371556 8.000980e-09 8.097 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.010276e-08 7.996 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.079370e-08 7.967 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.301699e-08 7.885 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.545700e-08 7.811 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.850937e-08 7.733 0 0
Nucleosome assembly R-HSA-774815 1.850937e-08 7.733 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.295715e-08 7.639 0 0
Cell-Cell communication R-HSA-1500931 3.006636e-08 7.522 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.644241e-08 7.438 0 0
Apoptosis R-HSA-109581 4.969498e-08 7.304 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.551588e-08 7.256 0 0
Chromatin organization R-HSA-4839726 5.884713e-08 7.230 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.780034e-08 7.169 0 0
Chromatin modifying enzymes R-HSA-3247509 1.029694e-07 6.987 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.048085e-07 6.980 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.157003e-07 6.937 0 0
HATs acetylate histones R-HSA-3214847 1.187028e-07 6.926 0 0
Packaging Of Telomere Ends R-HSA-171306 1.236288e-07 6.908 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.391333e-07 6.857 0 0
Selenoamino acid metabolism R-HSA-2408522 1.710831e-07 6.767 0 0
Meiotic synapsis R-HSA-1221632 2.164328e-07 6.665 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.152224e-07 6.667 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.359857e-07 6.627 0 0
G2/M Checkpoints R-HSA-69481 2.332970e-07 6.632 0 0
DNA methylation R-HSA-5334118 2.776386e-07 6.557 0 0
HDACs deacetylate histones R-HSA-3214815 3.746131e-07 6.426 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.874046e-07 6.412 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.874046e-07 6.412 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.708966e-07 6.431 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.457287e-07 6.351 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.303955e-07 6.275 0 0
Viral Infection Pathways R-HSA-9824446 6.418919e-07 6.193 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.314066e-07 6.200 0 0
RNA Polymerase I Transcription R-HSA-73864 6.928707e-07 6.159 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.778478e-07 6.109 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.711356e-07 6.060 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.436643e-07 6.074 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.331251e-07 6.030 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.050823e-06 5.978 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.230694e-06 5.910 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.597875e-06 5.796 0 0
Cell junction organization R-HSA-446728 1.580832e-06 5.801 0 0
Gene Silencing by RNA R-HSA-211000 1.824248e-06 5.739 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.253761e-06 5.647 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.359368e-06 5.627 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.359368e-06 5.627 0 0
Mitotic Anaphase R-HSA-68882 2.972360e-06 5.527 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.328964e-06 5.478 0 0
Programmed Cell Death R-HSA-5357801 3.884800e-06 5.411 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.943676e-06 5.404 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.497895e-06 5.347 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.786553e-06 5.320 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.750818e-06 5.323 0 0
Signaling by Hippo R-HSA-2028269 4.821755e-06 5.317 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.150224e-06 5.288 0 0
Separation of Sister Chromatids R-HSA-2467813 5.523996e-06 5.258 0 0
HCMV Early Events R-HSA-9609690 5.689418e-06 5.245 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.754763e-06 5.240 0 0
Cleavage of the damaged purine R-HSA-110331 5.754763e-06 5.240 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.205383e-06 5.207 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.852564e-06 5.164 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.484492e-06 5.126 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.095385e-06 5.092 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.989443e-06 5.097 0 0
Depurination R-HSA-73927 7.666261e-06 5.115 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.984045e-06 5.098 0 0
Depyrimidination R-HSA-73928 7.984045e-06 5.098 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.398416e-06 5.076 0 0
Cellular Senescence R-HSA-2559583 8.957439e-06 5.048 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.716193e-06 5.013 0 0
Defective pyroptosis R-HSA-9710421 1.036520e-05 4.984 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.071992e-05 4.970 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.072407e-05 4.970 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.324280e-05 4.878 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.271025e-05 4.896 0 0
ESR-mediated signaling R-HSA-8939211 1.355261e-05 4.868 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.376958e-05 4.861 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.551029e-05 4.809 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.726207e-05 4.763 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.810685e-05 4.742 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.862749e-05 4.730 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.862749e-05 4.730 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.726207e-05 4.763 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.178483e-05 4.662 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.178483e-05 4.662 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.178483e-05 4.662 0 0
Signaling by RAS mutants R-HSA-6802949 2.178483e-05 4.662 0 0
Chromosome Maintenance R-HSA-73886 2.178700e-05 4.662 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.207930e-05 4.656 0 0
mRNA Splicing R-HSA-72172 3.192150e-05 4.496 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.261384e-05 4.487 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.924310e-05 4.406 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.642628e-05 4.439 0 0
Nuclear import of Rev protein R-HSA-180746 3.675490e-05 4.435 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.924310e-05 4.406 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.924310e-05 4.406 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.230094e-05 4.374 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.774333e-05 4.321 0 0
Attenuation phase R-HSA-3371568 4.774333e-05 4.321 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.800893e-05 4.319 0 0
HSF1 activation R-HSA-3371511 6.218092e-05 4.206 0 0
Meiosis R-HSA-1500620 6.275885e-05 4.202 0 0
SARS-CoV Infections R-HSA-9679506 6.537432e-05 4.185 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.566397e-05 4.183 0 0
MAP2K and MAPK activation R-HSA-5674135 7.697016e-05 4.114 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.697016e-05 4.114 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.231300e-05 4.141 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.337074e-05 4.134 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.018548e-04 3.992 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.141322e-04 3.943 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.223310e-04 3.912 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.289074e-04 3.890 0 0
PECAM1 interactions R-HSA-210990 1.314977e-04 3.881 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.314977e-04 3.881 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.341300e-04 3.872 0 0
Regulation of KIT signaling R-HSA-1433559 1.379345e-04 3.860 0 0
L1CAM interactions R-HSA-373760 1.429949e-04 3.845 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.744620e-04 3.758 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.744620e-04 3.758 0 0
Metalloprotease DUBs R-HSA-5689901 1.703934e-04 3.769 0 0
DNA Double Strand Break Response R-HSA-5693606 1.619241e-04 3.791 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.829202e-04 3.738 0 0
Signaling by ALK in cancer R-HSA-9700206 1.829202e-04 3.738 0 0
Homology Directed Repair R-HSA-5693538 1.835169e-04 3.736 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.929296e-04 3.715 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.958736e-04 3.708 0 0
HSF1-dependent transactivation R-HSA-3371571 2.029125e-04 3.693 0 0
Meiotic recombination R-HSA-912446 2.029125e-04 3.693 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.042448e-04 3.690 0 0
Semaphorin interactions R-HSA-373755 2.230724e-04 3.652 0 0
Telomere Maintenance R-HSA-157579 2.319192e-04 3.635 0 0
Adherens junctions interactions R-HSA-418990 2.356288e-04 3.628 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.665646e-04 3.574 0 0
Recycling pathway of L1 R-HSA-437239 2.773412e-04 3.557 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.870618e-04 3.542 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.870618e-04 3.542 0 0
Cell-cell junction organization R-HSA-421270 3.249474e-04 3.488 0 0
Diseases of programmed cell death R-HSA-9645723 2.906101e-04 3.537 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.476660e-04 3.459 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.522570e-04 3.453 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.634866e-04 3.440 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.634866e-04 3.440 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.199131e-04 3.377 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.168415e-04 3.287 0 0
HCMV Infection R-HSA-9609646 5.353443e-04 3.271 0 0
Post NMDA receptor activation events R-HSA-438064 6.052206e-04 3.218 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.509228e-04 3.186 0 0
Interleukin-12 signaling R-HSA-9020591 6.631346e-04 3.178 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.739405e-04 3.171 0 0
mRNA 3'-end processing R-HSA-72187 6.970636e-04 3.157 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.991510e-04 3.155 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.310233e-04 3.080 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.377997e-04 3.077 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.653469e-04 3.063 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.653469e-04 3.063 0 0
Developmental Biology R-HSA-1266738 1.046335e-03 2.980 0 0
Signaling by WNT R-HSA-195721 1.101382e-03 2.958 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.136019e-03 2.945 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.136019e-03 2.945 0 0
Ub-specific processing proteases R-HSA-5689880 1.219237e-03 2.914 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.136019e-03 2.945 0 0
EPH-Ephrin signaling R-HSA-2682334 1.296582e-03 2.887 0 0
Deubiquitination R-HSA-5688426 1.337970e-03 2.874 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.344857e-03 2.871 0 0
RAF activation R-HSA-5673000 1.451317e-03 2.838 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.452923e-03 2.838 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.544747e-03 2.811 0 0
Selective autophagy R-HSA-9663891 1.575741e-03 2.803 0 0
Translation R-HSA-72766 1.579744e-03 2.801 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.588822e-03 2.799 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.594117e-03 2.797 0 0
Activation of BH3-only proteins R-HSA-114452 1.615303e-03 2.792 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.620342e-03 2.790 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.756540e-03 2.755 0 0
Reproduction R-HSA-1474165 1.768266e-03 2.752 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.851599e-03 2.732 0 0
FLT3 Signaling R-HSA-9607240 1.851599e-03 2.732 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.851599e-03 2.732 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.965940e-03 2.706 0 0
Base Excision Repair R-HSA-73884 2.000733e-03 2.699 0 0
snRNP Assembly R-HSA-191859 2.113325e-03 2.675 0 0
Metabolism of non-coding RNA R-HSA-194441 2.113325e-03 2.675 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.377327e-03 2.624 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.423713e-03 2.616 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.684752e-03 2.571 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.684752e-03 2.571 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.605286e-03 2.584 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.901175e-03 2.537 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.901175e-03 2.537 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.635770e-03 2.579 1 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.633068e-03 2.580 0 0
MTOR signalling R-HSA-165159 2.616815e-03 2.582 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.773475e-03 2.557 1 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.806302e-03 2.552 0 0
Interleukin-12 family signaling R-HSA-447115 3.073538e-03 2.512 0 0
Ephrin signaling R-HSA-3928664 3.124505e-03 2.505 0 0
HCMV Late Events R-HSA-9610379 3.378805e-03 2.471 0 0
Signaling by EGFR R-HSA-177929 3.388754e-03 2.470 0 0
G2/M Transition R-HSA-69275 3.440165e-03 2.463 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.440545e-03 2.463 0 0
Glycolysis R-HSA-70171 3.542627e-03 2.451 0 0
Striated Muscle Contraction R-HSA-390522 3.573110e-03 2.447 0 0
RMTs methylate histone arginines R-HSA-3214858 3.623234e-03 2.441 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.703770e-03 2.431 0 0
Suppression of apoptosis R-HSA-9635465 3.729697e-03 2.428 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.740174e-03 2.427 0 0
Growth hormone receptor signaling R-HSA-982772 3.740174e-03 2.427 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.984770e-03 2.400 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.082383e-03 2.389 0 0
DCC mediated attractive signaling R-HSA-418885 4.082383e-03 2.389 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.203373e-03 2.376 0 0
Aggrephagy R-HSA-9646399 4.308036e-03 2.366 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.341275e-03 2.362 0 0
G alpha (12/13) signalling events R-HSA-416482 4.584056e-03 2.339 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.927732e-03 2.307 0 0
Interleukin-37 signaling R-HSA-9008059 4.974793e-03 2.303 0 0
Nephrin family interactions R-HSA-373753 5.100278e-03 2.292 0 0
Co-inhibition by PD-1 R-HSA-389948 5.425592e-03 2.266 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.915857e-03 2.228 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.915857e-03 2.228 0 0
Amyloid fiber formation R-HSA-977225 6.414847e-03 2.193 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.910506e-03 2.160 0 0
Signaling by VEGF R-HSA-194138 7.151330e-03 2.146 1 0
tRNA processing in the nucleus R-HSA-6784531 7.447088e-03 2.128 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.371891e-03 2.077 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.371891e-03 2.077 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.649672e-03 2.063 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.011841e-02 1.995 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.252415e-03 2.034 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.774340e-03 2.057 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.002013e-02 1.999 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.807214e-03 2.055 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.180160e-03 2.037 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.011841e-02 1.995 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.736468e-03 2.012 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.116146e-03 2.040 0 0
Infectious disease R-HSA-5663205 8.529133e-03 2.069 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.098268e-02 1.959 0 0
Platelet sensitization by LDL R-HSA-432142 1.098268e-02 1.959 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.098268e-02 1.959 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.116950e-02 1.952 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.194949e-02 1.923 0 0
Signal attenuation R-HSA-74749 1.209523e-02 1.917 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.285488e-02 1.891 0 0
Signaling by ERBB2 R-HSA-1227986 1.301276e-02 1.886 0 0
Kinesins R-HSA-983189 1.301276e-02 1.886 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.450507e-02 1.838 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.456392e-02 1.837 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.521623e-02 1.818 0 0
Protein methylation R-HSA-8876725 1.521623e-02 1.818 0 0
Co-stimulation by CD28 R-HSA-389356 1.553061e-02 1.809 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.553061e-02 1.809 0 0
MET interacts with TNS proteins R-HSA-8875513 1.566517e-02 1.805 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.566517e-02 1.805 0 0
RET signaling R-HSA-8853659 1.568525e-02 1.805 0 0
MAPK family signaling cascades R-HSA-5683057 1.612692e-02 1.792 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.612927e-02 1.792 0 0
Signaling by NTRKs R-HSA-166520 1.628883e-02 1.788 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.643728e-02 1.784 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.656321e-02 1.781 0 0
Autophagy R-HSA-9612973 1.657820e-02 1.780 0 0
Long-term potentiation R-HSA-9620244 1.682198e-02 1.774 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.721533e-02 1.764 0 0
Gap junction trafficking and regulation R-HSA-157858 1.754168e-02 1.756 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.808896e-02 1.743 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.808896e-02 1.743 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.862142e-02 1.730 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.862142e-02 1.730 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.862142e-02 1.730 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.862142e-02 1.730 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.862142e-02 1.730 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.862142e-02 1.730 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.872615e-02 1.728 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.908070e-02 1.719 0 0
Signaling by SCF-KIT R-HSA-1433557 1.911390e-02 1.719 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.976319e-02 1.704 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.992405e-02 1.701 0 0
Glucose metabolism R-HSA-70326 2.053815e-02 1.687 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.097113e-02 1.678 0 0
Regulation of TP53 Activity R-HSA-5633007 2.142869e-02 1.669 0 0
Netrin-1 signaling R-HSA-373752 2.163224e-02 1.665 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.212431e-02 1.655 0 0
Regulation of gap junction activity R-HSA-191650 2.511140e-02 1.600 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.511140e-02 1.600 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.667304e-02 1.574 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.667304e-02 1.574 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.667304e-02 1.574 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.667304e-02 1.574 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.667304e-02 1.574 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.454359e-02 1.610 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.511140e-02 1.600 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.667304e-02 1.574 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.667304e-02 1.574 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.243951e-02 1.649 1 0
Neurexins and neuroligins R-HSA-6794361 2.475054e-02 1.606 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.488311e-02 1.604 0 0
Macroautophagy R-HSA-1632852 2.677663e-02 1.572 0 0
Membrane Trafficking R-HSA-199991 2.500965e-02 1.602 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.511140e-02 1.600 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.356210e-02 1.628 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.784618e-02 1.555 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.829466e-02 1.548 0 0
Type I hemidesmosome assembly R-HSA-446107 2.848663e-02 1.545 0 0
Adrenoceptors R-HSA-390696 2.848663e-02 1.545 0 0
Protein ubiquitination R-HSA-8852135 2.896120e-02 1.538 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.970854e-02 1.527 0 0
Muscle contraction R-HSA-397014 2.999591e-02 1.523 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.037536e-02 1.517 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.310706e-02 1.480 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.320697e-02 1.479 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.320697e-02 1.479 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.417763e-02 1.466 0 0
Signaling by TGFB family members R-HSA-9006936 3.444654e-02 1.463 1 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.600902e-02 1.444 0 0
DNA Replication R-HSA-69306 3.649166e-02 1.438 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.657245e-02 1.437 1 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.664387e-02 1.436 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.700779e-02 1.432 0 0
WNT mediated activation of DVL R-HSA-201688 3.728422e-02 1.428 0 0
Gap junction degradation R-HSA-190873 3.728422e-02 1.428 0 0
ALK mutants bind TKIs R-HSA-9700645 3.728422e-02 1.428 0 0
NRAGE signals death through JNK R-HSA-193648 3.745607e-02 1.426 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.748181e-02 1.426 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.815226e-02 1.418 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.815226e-02 1.418 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.815226e-02 1.418 0 0
Death Receptor Signaling R-HSA-73887 3.865050e-02 1.413 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.865654e-02 1.413 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.917086e-02 1.407 0 0
The NLRP3 inflammasome R-HSA-844456 4.057763e-02 1.392 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.124437e-02 1.385 0 0
Signaling by FGFR2 R-HSA-5654738 4.411475e-02 1.355 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.466054e-02 1.350 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.466054e-02 1.350 0 0
HIV Life Cycle R-HSA-162587 4.569807e-02 1.340 0 0
Gene expression (Transcription) R-HSA-74160 4.586180e-02 1.339 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.602564e-02 1.337 0 0
Gap junction trafficking R-HSA-190828 4.719441e-02 1.326 0 0
Signaling by Leptin R-HSA-2586552 4.747363e-02 1.324 0 0
Negative regulation of MET activity R-HSA-6807004 4.768762e-02 1.322 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.930337e-02 1.307 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.930337e-02 1.307 0 0
Interferon Signaling R-HSA-913531 4.993171e-02 1.302 0 0
Myogenesis R-HSA-525793 5.123283e-02 1.290 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.123283e-02 1.290 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.129129e-02 1.290 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.129129e-02 1.290 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.129129e-02 1.290 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.129129e-02 1.290 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.129129e-02 1.290 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.514396e-02 1.186 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.514396e-02 1.186 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.514396e-02 1.186 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.514396e-02 1.186 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.905023e-02 1.229 0 0
Signaling by APC mutants R-HSA-4839744 5.905023e-02 1.229 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.905023e-02 1.229 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.905023e-02 1.229 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.905023e-02 1.229 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.875551e-02 1.231 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.408453e-02 1.193 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.408453e-02 1.193 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.408453e-02 1.193 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.838380e-02 1.234 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.612027e-02 1.180 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.612027e-02 1.180 0 0
Centrosome maturation R-HSA-380287 5.403716e-02 1.267 0 0
Integrin signaling R-HSA-354192 5.272423e-02 1.278 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.612027e-02 1.180 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.838380e-02 1.234 0 0
Mitophagy R-HSA-5205647 6.624585e-02 1.179 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.321572e-02 1.199 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.272423e-02 1.278 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.703309e-02 1.174 0 0
Nef and signal transduction R-HSA-164944 6.783777e-02 1.169 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.272423e-02 1.278 0 0
Host Interactions of HIV factors R-HSA-162909 5.498548e-02 1.260 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.408453e-02 1.193 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.408453e-02 1.193 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.272423e-02 1.278 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.272423e-02 1.278 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.741636e-02 1.241 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.408453e-02 1.193 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.408453e-02 1.193 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.291942e-02 1.276 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.961739e-02 1.157 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.408453e-02 1.193 0 0
FOXO-mediated transcription R-HSA-9614085 6.984026e-02 1.156 0 0
DNA Repair R-HSA-73894 7.162515e-02 1.145 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.198781e-02 1.143 0 0
Activation of RAC1 R-HSA-428540 7.198781e-02 1.143 0 0
NF-kB is activated and signals survival R-HSA-209560 7.198781e-02 1.143 0 0
Signaling by AXIN mutants R-HSA-4839735 7.198781e-02 1.143 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.198781e-02 1.143 0 0
Signaling by KIT in disease R-HSA-9669938 7.338053e-02 1.134 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.338053e-02 1.134 0 0
FGFR2 alternative splicing R-HSA-6803529 7.338053e-02 1.134 0 0
mTORC1-mediated signalling R-HSA-166208 7.338053e-02 1.134 0 0
Signalling to ERKs R-HSA-187687 7.373960e-02 1.132 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.444551e-02 1.128 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.544772e-02 1.122 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.699356e-02 1.114 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.699356e-02 1.114 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.825553e-02 1.106 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.920756e-02 1.101 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.935681e-02 1.100 0 0
RUNX2 regulates bone development R-HSA-8941326 8.172508e-02 1.088 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.624119e-02 1.064 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.647947e-02 1.063 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.647947e-02 1.063 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.647947e-02 1.063 0 0
SOS-mediated signalling R-HSA-112412 8.647947e-02 1.063 0 0
Regulation of PTEN localization R-HSA-8948747 8.647947e-02 1.063 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.647947e-02 1.063 0 0
Signaling by FGFR4 R-HSA-5654743 8.682847e-02 1.061 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.682847e-02 1.061 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.282607e-02 1.032 0 0
EGFR downregulation R-HSA-182971 9.285764e-02 1.032 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.414806e-02 1.026 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.414806e-02 1.026 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.487026e-02 1.023 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.527895e-02 1.021 0 0
MET activates PTPN11 R-HSA-8865999 9.527895e-02 1.021 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.533571e-02 1.021 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.707410e-02 1.013 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.754464e-02 1.011 0 0
Drug resistance of KIT mutants R-HSA-9669937 9.817789e-02 1.008 0 0
KIT mutants bind TKIs R-HSA-9669921 9.817789e-02 1.008 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 9.817789e-02 1.008 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 9.817789e-02 1.008 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 9.817789e-02 1.008 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.817789e-02 1.008 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 9.817789e-02 1.008 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 9.817789e-02 1.008 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 9.817789e-02 1.008 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 9.817789e-02 1.008 0 0
Inositol phosphate metabolism R-HSA-1483249 9.873948e-02 1.006 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.017490e-01 0.992 0 0
Frs2-mediated activation R-HSA-170968 1.017490e-01 0.992 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.017490e-01 0.992 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.029336e-01 0.987 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.033306e-01 0.986 0 0
Signaling by FGFR3 R-HSA-5654741 1.033306e-01 0.986 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.041703e-01 0.982 0 0
TGFBR3 expression R-HSA-9839394 1.055958e-01 0.976 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.055958e-01 0.976 0 0
Smooth Muscle Contraction R-HSA-445355 1.059859e-01 0.975 0 0
Rap1 signalling R-HSA-392517 1.060209e-01 0.975 0 0
Signaling by FGFR R-HSA-190236 1.065938e-01 0.972 0 0
Formation of annular gap junctions R-HSA-196025 1.070192e-01 0.971 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.070192e-01 0.971 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.070192e-01 0.971 0 0
Signaling by TGFBR3 R-HSA-9839373 1.122053e-01 0.950 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.135765e-01 0.945 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.135765e-01 0.945 0 0
G-protein beta:gamma signalling R-HSA-397795 1.135765e-01 0.945 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.177287e-01 0.929 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.184365e-01 0.927 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.184365e-01 0.927 0 0
Prolactin receptor signaling R-HSA-1170546 1.184365e-01 0.927 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.285093e-01 0.891 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.285093e-01 0.891 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.285093e-01 0.891 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.285093e-01 0.891 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.639375e-01 0.785 0 0
IRS activation R-HSA-74713 1.639375e-01 0.785 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.639375e-01 0.785 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.639375e-01 0.785 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.639375e-01 0.785 0 0
Defective F9 activation R-HSA-9673221 1.639375e-01 0.785 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.292416e-01 0.889 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.292416e-01 0.889 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.529223e-01 0.816 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.362180e-01 0.866 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.200809e-01 0.921 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.549997e-01 0.810 0 0
Disorders of Developmental Biology R-HSA-9675151 1.746816e-01 0.758 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.746816e-01 0.758 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.365063e-01 0.865 0 0
DAP12 signaling R-HSA-2424491 1.725804e-01 0.763 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.214888e-01 0.915 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.510400e-01 0.821 0 0
PKR-mediated signaling R-HSA-9833482 1.305350e-01 0.884 0 0
Protein folding R-HSA-391251 1.773559e-01 0.751 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.292416e-01 0.889 0 0
Regulation of CDH1 Function R-HSA-9764561 1.415524e-01 0.849 0 0
Regulation of CDH11 function R-HSA-9762292 1.529223e-01 0.816 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.365063e-01 0.865 0 0
Dopamine receptors R-HSA-390651 1.285093e-01 0.891 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.725804e-01 0.763 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.256187e-01 0.901 1 0
COPI-mediated anterograde transport R-HSA-6807878 1.493964e-01 0.826 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.566749e-01 0.805 0 0
p75NTR signals via NF-kB R-HSA-193639 1.362180e-01 0.866 0 0
Signaling by FGFR1 R-HSA-5654736 1.321344e-01 0.879 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.292416e-01 0.889 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.746816e-01 0.758 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.639375e-01 0.785 0 0
HIV Infection R-HSA-162906 1.599715e-01 0.796 0 0
Gap junction assembly R-HSA-190861 1.365063e-01 0.865 0 0
GPVI-mediated activation cascade R-HSA-114604 1.615047e-01 0.792 1 1
Signaling by PTK6 R-HSA-8848021 1.236595e-01 0.908 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.236595e-01 0.908 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.579819e-01 0.801 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.487575e-01 0.828 0 0
Ion transport by P-type ATPases R-HSA-936837 1.321899e-01 0.879 0 0
Prolonged ERK activation events R-HSA-169893 1.549997e-01 0.810 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.506184e-01 0.822 0 0
RNA Polymerase II Transcription R-HSA-73857 1.458416e-01 0.836 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.285093e-01 0.891 0 0
MTF1 activates gene expression R-HSA-5660489 1.285093e-01 0.891 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.292416e-01 0.889 0 0
Unwinding of DNA R-HSA-176974 1.292416e-01 0.889 0 0
Basigin interactions R-HSA-210991 1.349629e-01 0.870 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.506184e-01 0.822 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.718015e-01 0.765 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.321344e-01 0.879 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.744311e-01 0.758 0 0
Amine ligand-binding receptors R-HSA-375280 1.748499e-01 0.757 0 0
Signaling by NOTCH R-HSA-157118 1.375553e-01 0.862 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.247729e-01 0.904 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.292416e-01 0.889 0 0
Inflammasomes R-HSA-622312 1.439513e-01 0.842 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.407535e-01 0.852 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.529223e-01 0.816 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.669940e-01 0.777 0 0
NGF-stimulated transcription R-HSA-9031628 1.311737e-01 0.882 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.627420e-01 0.789 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.510400e-01 0.821 0 0
Co-inhibition by BTLA R-HSA-9927353 1.639375e-01 0.785 0 0
NrCAM interactions R-HSA-447038 1.639375e-01 0.785 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.292416e-01 0.889 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.778350e-01 0.750 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.639375e-01 0.785 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.219002e-01 0.914 0 0
IRE1alpha activates chaperones R-HSA-381070 1.687590e-01 0.773 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.784064e-01 0.749 0 0
Syndecan interactions R-HSA-3000170 1.840321e-01 0.735 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.867221e-01 0.729 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.867221e-01 0.729 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.867221e-01 0.729 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.867221e-01 0.729 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.867221e-01 0.729 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.867221e-01 0.729 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.867221e-01 0.729 0 0
Inhibition of PKR R-HSA-169131 1.867221e-01 0.729 0 0
Trafficking of AMPA receptors R-HSA-399719 1.877094e-01 0.727 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.885111e-01 0.725 0 0
Specification of primordial germ cells R-HSA-9827857 1.951599e-01 0.710 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.003547e-01 0.698 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.008124e-01 0.697 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.008124e-01 0.697 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.008124e-01 0.697 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.008124e-01 0.697 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.016725e-01 0.695 0 0
Neurodegenerative Diseases R-HSA-8863678 2.016725e-01 0.695 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.016725e-01 0.695 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.665774e-01 0.574 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.665774e-01 0.574 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.665774e-01 0.574 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.665774e-01 0.574 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.665774e-01 0.574 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.665774e-01 0.574 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.665774e-01 0.574 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.665774e-01 0.574 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.665774e-01 0.574 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.665774e-01 0.574 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.665774e-01 0.574 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.665774e-01 0.574 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.665774e-01 0.574 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.385960e-01 0.470 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.385960e-01 0.470 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.385960e-01 0.470 0 0
Potassium transport channels R-HSA-1296067 3.385960e-01 0.470 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.385960e-01 0.470 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.385960e-01 0.470 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.385960e-01 0.470 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.385960e-01 0.470 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.037568e-01 0.691 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.037568e-01 0.691 0 0
ERKs are inactivated R-HSA-202670 2.037568e-01 0.691 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.765107e-01 0.558 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.765107e-01 0.558 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.765107e-01 0.558 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.765107e-01 0.558 0 0
PLC-gamma1 signalling R-HSA-167021 4.035466e-01 0.394 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.035466e-01 0.394 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.035466e-01 0.394 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.035466e-01 0.394 0 0
Invadopodia formation R-HSA-8941237 4.035466e-01 0.394 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.035466e-01 0.394 0 0
Disorders of Nervous System Development R-HSA-9697154 2.304725e-01 0.637 0 0
Pervasive developmental disorders R-HSA-9005895 2.304725e-01 0.637 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.304725e-01 0.637 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.304725e-01 0.637 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.143946e-01 0.503 0 0
phospho-PLA2 pathway R-HSA-111995 3.143946e-01 0.503 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.577774e-01 0.589 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.577774e-01 0.589 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.518177e-01 0.454 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.518177e-01 0.454 1 1
Lipophagy R-HSA-9613354 3.518177e-01 0.454 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.518177e-01 0.454 0 0
CASP8 activity is inhibited R-HSA-5218900 3.518177e-01 0.454 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.134017e-01 0.504 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.134017e-01 0.504 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.134017e-01 0.504 1 1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.829230e-01 0.548 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.829230e-01 0.548 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.829230e-01 0.548 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.885054e-01 0.411 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.885054e-01 0.411 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.885054e-01 0.411 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.885054e-01 0.411 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.885054e-01 0.411 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.885054e-01 0.411 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.413807e-01 0.467 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.769868e-01 0.558 0 0
Dual Incision in GG-NER R-HSA-5696400 2.527155e-01 0.597 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.527155e-01 0.597 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.966812e-01 0.528 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.692694e-01 0.433 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.692694e-01 0.433 0 0
Activation of the pre-replicative complex R-HSA-68962 3.165944e-01 0.499 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.165944e-01 0.499 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.109917e-01 0.676 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.969358e-01 0.401 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.969358e-01 0.401 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.969358e-01 0.401 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.969358e-01 0.401 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.751906e-01 0.426 0 0
Deadenylation of mRNA R-HSA-429947 3.751906e-01 0.426 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.407972e-01 0.468 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.264771e-01 0.486 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.982758e-01 0.400 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.215234e-01 0.655 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.405325e-01 0.619 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.951801e-01 0.403 0 0
DNA Damage Bypass R-HSA-73893 2.407647e-01 0.618 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.874186e-01 0.412 0 0
Signaling by MET R-HSA-6806834 2.056343e-01 0.687 0 0
Translesion Synthesis by POLH R-HSA-110320 2.380821e-01 0.623 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.854797e-01 0.544 0 0
ERK/MAPK targets R-HSA-198753 2.829230e-01 0.548 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.571108e-01 0.590 0 0
Signal amplification R-HSA-392518 2.527155e-01 0.597 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.228110e-01 0.491 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.885054e-01 0.411 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.765107e-01 0.558 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.765107e-01 0.558 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.518177e-01 0.454 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.193994e-01 0.659 0 0
PI3K/AKT activation R-HSA-198203 3.885054e-01 0.411 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.358760e-01 0.627 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.413807e-01 0.467 0 0
DNA strand elongation R-HSA-69190 3.568332e-01 0.448 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.568332e-01 0.448 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.407647e-01 0.618 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.751906e-01 0.426 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.037568e-01 0.691 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.304725e-01 0.637 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.518177e-01 0.454 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.134017e-01 0.504 0 0
Binding and entry of HIV virion R-HSA-173107 3.885054e-01 0.411 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.885054e-01 0.411 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.692694e-01 0.433 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.873052e-01 0.542 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.520300e-01 0.453 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.647489e-01 0.577 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.165944e-01 0.499 0 0
Leishmania phagocytosis R-HSA-9664417 3.613064e-01 0.442 0 0
Parasite infection R-HSA-9664407 3.613064e-01 0.442 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.613064e-01 0.442 0 0
PTEN Regulation R-HSA-6807070 3.515193e-01 0.454 0 0
Signal transduction by L1 R-HSA-445144 2.603144e-01 0.585 0 0
S Phase R-HSA-69242 2.042333e-01 0.690 0 0
Degradation of CDH1 R-HSA-9766229 3.760164e-01 0.425 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.681692e-01 0.434 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.037568e-01 0.691 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.163288e-01 0.665 0 0
Polo-like kinase mediated events R-HSA-156711 2.163288e-01 0.665 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.854797e-01 0.544 0 0
Calcineurin activates NFAT R-HSA-2025928 3.518177e-01 0.454 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.885054e-01 0.411 0 0
Josephin domain DUBs R-HSA-5689877 3.885054e-01 0.411 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.885054e-01 0.411 0 0
Killing mechanisms R-HSA-9664420 3.413807e-01 0.467 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.413807e-01 0.467 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.692694e-01 0.433 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.692694e-01 0.433 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.969358e-01 0.401 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.982758e-01 0.400 1 1
Tight junction interactions R-HSA-420029 3.982758e-01 0.400 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.075270e-01 0.683 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.049658e-01 0.516 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.163288e-01 0.665 0 0
UCH proteinases R-HSA-5689603 2.564325e-01 0.591 0 0
Signaling by WNT in cancer R-HSA-4791275 2.033296e-01 0.692 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.836545e-01 0.416 0 0
Signaling by NOTCH1 R-HSA-1980143 2.564325e-01 0.591 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.836545e-01 0.416 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.518177e-01 0.454 0 0
p38MAPK events R-HSA-171007 3.134017e-01 0.504 0 0
Ion homeostasis R-HSA-5578775 2.217393e-01 0.654 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.366649e-01 0.473 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.056343e-01 0.687 0 0
Oncogene Induced Senescence R-HSA-2559585 2.698735e-01 0.569 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.854797e-01 0.544 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.692694e-01 0.433 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.770419e-01 0.424 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.770226e-01 0.424 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.972366e-01 0.401 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.966812e-01 0.528 0 0
MAP kinase activation R-HSA-450294 2.877734e-01 0.541 0 0
G-protein mediated events R-HSA-112040 3.725358e-01 0.429 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.380821e-01 0.623 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.665774e-01 0.574 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.665774e-01 0.574 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.665774e-01 0.574 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.665774e-01 0.574 0 0
Defective factor XII causes hereditary angioedema R-HSA-9657688 3.385960e-01 0.470 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.385089e-01 0.622 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.765107e-01 0.558 0 0
Netrin mediated repulsion signals R-HSA-418886 2.765107e-01 0.558 0 0
MET activates STAT3 R-HSA-8875791 4.035466e-01 0.394 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.035466e-01 0.394 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.304725e-01 0.637 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.577774e-01 0.589 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.163288e-01 0.665 0 0
Signalling to RAS R-HSA-167044 2.829230e-01 0.548 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.520300e-01 0.453 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.751906e-01 0.426 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.015865e-01 0.521 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.588816e-01 0.445 0 0
Diseases of Immune System R-HSA-5260271 3.588816e-01 0.445 0 0
Cilium Assembly R-HSA-5617833 3.295196e-01 0.482 0 0
Vesicle-mediated transport R-HSA-5653656 3.303234e-01 0.481 0 0
Adaptive Immune System R-HSA-1280218 2.355332e-01 0.628 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.193994e-01 0.659 0 0
TNF signaling R-HSA-75893 3.437819e-01 0.464 0 0
Generic Transcription Pathway R-HSA-212436 3.996180e-01 0.398 0 0
Hemostasis R-HSA-109582 2.361185e-01 0.627 1 0
Pexophagy R-HSA-9664873 3.885054e-01 0.411 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.317760e-01 0.635 0 0
GAB1 signalosome R-HSA-180292 2.163288e-01 0.665 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.304725e-01 0.637 0 0
PLC beta mediated events R-HSA-112043 2.877734e-01 0.541 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.296526e-01 0.482 0 0
Regulation of signaling by CBL R-HSA-912631 2.380821e-01 0.623 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.518177e-01 0.454 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.885054e-01 0.411 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.092791e-01 0.679 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.821992e-01 0.549 0 0
Ca-dependent events R-HSA-111996 2.623858e-01 0.581 0 0
Neuronal System R-HSA-112316 3.290785e-01 0.483 0 0
CHL1 interactions R-HSA-447041 2.765107e-01 0.558 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.765107e-01 0.558 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.518177e-01 0.454 0 0
Protein hydroxylation R-HSA-9629569 2.603144e-01 0.585 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.575744e-01 0.589 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.035911e-01 0.518 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.049658e-01 0.516 0 0
Rab regulation of trafficking R-HSA-9007101 3.804023e-01 0.420 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.803255e-01 0.552 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.665774e-01 0.574 0 0
Defective SERPING1 causes hereditary angioedema R-HSA-9657689 2.665774e-01 0.574 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.035466e-01 0.394 0 0
ARMS-mediated activation R-HSA-170984 3.518177e-01 0.454 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.193994e-01 0.659 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.413807e-01 0.467 0 0
Signaling by NOTCH3 R-HSA-9012852 3.285776e-01 0.483 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.588816e-01 0.445 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.561544e-01 0.591 0 0
Histamine receptors R-HSA-390650 4.035466e-01 0.394 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.869559e-01 0.412 0 0
Potential therapeutics for SARS R-HSA-9679191 3.777937e-01 0.423 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.165944e-01 0.499 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.665774e-01 0.574 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.385960e-01 0.470 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.385960e-01 0.470 0 0
Signaling by LTK in cancer R-HSA-9842640 2.385089e-01 0.622 0 0
Regulation of IFNG signaling R-HSA-877312 2.304725e-01 0.637 0 0
RSK activation R-HSA-444257 3.143946e-01 0.503 0 0
Apoptotic factor-mediated response R-HSA-111471 2.163288e-01 0.665 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.885054e-01 0.411 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 3.885054e-01 0.411 0 0
Negative regulation of FLT3 R-HSA-9706369 3.413807e-01 0.467 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.217393e-01 0.654 0 0
Signaling by ALK R-HSA-201556 3.407972e-01 0.468 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.413807e-01 0.467 0 0
Zinc transporters R-HSA-435354 2.854797e-01 0.544 0 0
Interleukin-7 signaling R-HSA-1266695 2.198525e-01 0.658 0 0
MHC class II antigen presentation R-HSA-2132295 3.458787e-01 0.461 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.518177e-01 0.454 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.575744e-01 0.589 0 0
OAS antiviral response R-HSA-8983711 2.304725e-01 0.637 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.143946e-01 0.503 0 0
Signal regulatory protein family interactions R-HSA-391160 2.854797e-01 0.544 0 0
Interleukin-1 processing R-HSA-448706 3.518177e-01 0.454 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.518177e-01 0.454 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.163288e-01 0.665 0 0
Signaling by Interleukins R-HSA-449147 3.146072e-01 0.502 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.037568e-01 0.691 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.885054e-01 0.411 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 3.692694e-01 0.433 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.770419e-01 0.424 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.143946e-01 0.503 0 0
SLC transporter disorders R-HSA-5619102 3.625318e-01 0.441 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.518177e-01 0.454 0 0
Formation of apoptosome R-HSA-111458 3.885054e-01 0.411 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.024727e-01 0.694 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.052824e-01 0.392 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.052824e-01 0.392 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.052824e-01 0.392 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.052824e-01 0.392 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.052824e-01 0.392 0 0
Interleukin-17 signaling R-HSA-448424 4.158631e-01 0.381 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.158631e-01 0.381 0 0
eNOS activation R-HSA-203615 4.173653e-01 0.379 0 0
Signaling by NOTCH2 R-HSA-1980145 4.173653e-01 0.379 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.173653e-01 0.379 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.212116e-01 0.375 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.212116e-01 0.375 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.212116e-01 0.375 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.212116e-01 0.375 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.242415e-01 0.372 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.242415e-01 0.372 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.242415e-01 0.372 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.242415e-01 0.372 0 0
Interleukin-2 signaling R-HSA-9020558 4.242415e-01 0.372 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.242627e-01 0.372 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.242627e-01 0.372 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.254195e-01 0.371 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.258604e-01 0.371 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.343832e-01 0.362 0 0
Heme signaling R-HSA-9707616 4.360996e-01 0.360 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.373793e-01 0.359 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.424042e-01 0.354 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.439301e-01 0.353 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.439301e-01 0.353 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.439301e-01 0.353 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.439301e-01 0.353 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.447298e-01 0.352 0 0
Platelet homeostasis R-HSA-418346 4.462349e-01 0.350 0 0
DAP12 interactions R-HSA-2172127 4.493724e-01 0.347 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.511475e-01 0.346 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.511475e-01 0.346 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.511475e-01 0.346 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.511475e-01 0.346 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.511475e-01 0.346 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.511475e-01 0.346 0 0
Diseases of hemostasis R-HSA-9671793 4.511475e-01 0.346 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.514436e-01 0.345 0 0
Disease R-HSA-1643685 4.568304e-01 0.340 0 0
FLT3 signaling in disease R-HSA-9682385 4.572329e-01 0.340 0 0
Calmodulin induced events R-HSA-111933 4.572329e-01 0.340 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 4.572329e-01 0.340 0 0
CaM pathway R-HSA-111997 4.572329e-01 0.340 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.588591e-01 0.338 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.588591e-01 0.338 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.588591e-01 0.338 0 0
Ca2+ pathway R-HSA-4086398 4.591014e-01 0.338 0 0
Leishmania infection R-HSA-9658195 4.599113e-01 0.337 0 0
Parasitic Infection Pathways R-HSA-9824443 4.599113e-01 0.337 0 0
HCN channels R-HSA-1296061 4.621224e-01 0.335 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.621224e-01 0.335 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.621224e-01 0.335 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.621224e-01 0.335 0 0
NADE modulates death signalling R-HSA-205025 4.621224e-01 0.335 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.621224e-01 0.335 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.621224e-01 0.335 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.663692e-01 0.331 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.665946e-01 0.331 0 0
DAG and IP3 signaling R-HSA-1489509 4.672259e-01 0.330 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.726830e-01 0.325 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.734080e-01 0.325 0 0
Signaling by ERBB4 R-HSA-1236394 4.734080e-01 0.325 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.775017e-01 0.321 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.775017e-01 0.321 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.775017e-01 0.321 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.775017e-01 0.321 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.775017e-01 0.321 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.775017e-01 0.321 0 0
Creatine metabolism R-HSA-71288 4.775017e-01 0.321 0 0
Formation of definitive endoderm R-HSA-9823730 4.775017e-01 0.321 0 0
Signaling by NODAL R-HSA-1181150 4.775017e-01 0.321 0 0
Neutrophil degranulation R-HSA-6798695 4.848462e-01 0.314 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.849202e-01 0.314 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.849202e-01 0.314 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.849202e-01 0.314 0 0
tRNA processing R-HSA-72306 4.878785e-01 0.312 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.884730e-01 0.311 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.884730e-01 0.311 0 0
Interleukin-1 family signaling R-HSA-446652 4.906803e-01 0.309 0 0
MET activates RAS signaling R-HSA-8851805 4.922334e-01 0.308 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.922334e-01 0.308 0 0
Repression of WNT target genes R-HSA-4641265 4.922334e-01 0.308 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.922334e-01 0.308 0 0
Polymerase switching R-HSA-69091 4.922334e-01 0.308 0 0
Leading Strand Synthesis R-HSA-69109 4.922334e-01 0.308 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.922334e-01 0.308 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.922334e-01 0.308 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.922334e-01 0.308 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.922334e-01 0.308 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.922334e-01 0.308 0 0
Signaling by LTK R-HSA-9842663 4.922334e-01 0.308 0 0
MET promotes cell motility R-HSA-8875878 4.962927e-01 0.304 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.962927e-01 0.304 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.962927e-01 0.304 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.972379e-01 0.303 0 0
Platelet degranulation R-HSA-114608 5.008876e-01 0.300 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.024261e-01 0.299 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.024261e-01 0.299 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.032493e-01 0.298 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 5.032493e-01 0.298 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.032493e-01 0.298 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.032493e-01 0.298 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.032493e-01 0.298 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.060175e-01 0.296 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.118998e-01 0.291 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.147084e-01 0.288 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.149488e-01 0.288 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.149488e-01 0.288 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.149488e-01 0.288 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.149488e-01 0.288 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.149488e-01 0.288 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.149488e-01 0.288 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.149488e-01 0.288 0 0
PTK6 Down-Regulation R-HSA-8849472 5.149488e-01 0.288 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.149488e-01 0.288 0 0
Activation of AKT2 R-HSA-165158 5.149488e-01 0.288 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.149488e-01 0.288 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.149488e-01 0.288 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.149488e-01 0.288 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.149488e-01 0.288 0 0
Reelin signalling pathway R-HSA-8866376 5.149488e-01 0.288 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.154239e-01 0.288 0 0
Intraflagellar transport R-HSA-5620924 5.197162e-01 0.284 0 0
Metal ion SLC transporters R-HSA-425410 5.197162e-01 0.284 0 0
Formation of axial mesoderm R-HSA-9796292 5.242748e-01 0.280 0 0
Maturation of nucleoprotein R-HSA-9683610 5.242748e-01 0.280 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.242748e-01 0.280 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.242748e-01 0.280 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.253818e-01 0.280 0 0
Opioid Signalling R-HSA-111885 5.253818e-01 0.280 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.283270e-01 0.277 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.283270e-01 0.277 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.283270e-01 0.277 0 0
PCP/CE pathway R-HSA-4086400 5.296572e-01 0.276 0 0
Downstream signal transduction R-HSA-186763 5.314808e-01 0.275 0 0
Generation of second messenger molecules R-HSA-202433 5.342447e-01 0.272 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.376113e-01 0.270 0 0
Extension of Telomeres R-HSA-180786 5.391086e-01 0.268 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.391086e-01 0.268 0 0
Sensory processing of sound R-HSA-9659379 5.433996e-01 0.265 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.456744e-01 0.263 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.526824e-01 0.258 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.526824e-01 0.258 0 0
Notch-HLH transcription pathway R-HSA-350054 5.526824e-01 0.258 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.526824e-01 0.258 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.527259e-01 0.257 0 0
Transmission across Chemical Synapses R-HSA-112315 5.531562e-01 0.257 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.549231e-01 0.256 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.549231e-01 0.256 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.549231e-01 0.256 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.549231e-01 0.256 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.549231e-01 0.256 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.557548e-01 0.255 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.557548e-01 0.255 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.625897e-01 0.250 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.625897e-01 0.250 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.625897e-01 0.250 0 0
Signaling by MAPK mutants R-HSA-9652817 5.625897e-01 0.250 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.625897e-01 0.250 0 0
PKB-mediated events R-HSA-109703 5.625897e-01 0.250 0 0
Synthesis of PS R-HSA-1483101 5.625897e-01 0.250 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.625897e-01 0.250 0 0
PDE3B signalling R-HSA-165160 5.625897e-01 0.250 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.625897e-01 0.250 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.625897e-01 0.250 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.625897e-01 0.250 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.625897e-01 0.250 0 0
Maturation of protein E R-HSA-9694493 5.625897e-01 0.250 0 0
Maturation of protein E R-HSA-9683683 5.625897e-01 0.250 0 0
TRAIL signaling R-HSA-75158 5.625897e-01 0.250 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.625897e-01 0.250 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.672130e-01 0.246 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.698433e-01 0.244 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.708414e-01 0.243 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.716624e-01 0.243 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.716624e-01 0.243 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.716624e-01 0.243 0 0
Ion channel transport R-HSA-983712 5.720730e-01 0.243 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.726219e-01 0.242 0 0
Erythropoietin activates RAS R-HSA-9027284 5.841429e-01 0.233 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.841429e-01 0.233 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.841429e-01 0.233 0 0
Translesion synthesis by REV1 R-HSA-110312 5.841429e-01 0.233 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.841429e-01 0.233 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.841429e-01 0.233 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.841429e-01 0.233 0 0
Biotin transport and metabolism R-HSA-196780 5.841429e-01 0.233 0 0
Signaling by Activin R-HSA-1502540 5.841429e-01 0.233 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.848468e-01 0.233 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.848468e-01 0.233 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.862476e-01 0.232 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.862476e-01 0.232 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.924124e-01 0.227 0 0
Hedgehog 'off' state R-HSA-5610787 5.954708e-01 0.225 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.990683e-01 0.223 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.021232e-01 0.220 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.021232e-01 0.220 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.055540e-01 0.218 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.055540e-01 0.218 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.055540e-01 0.218 0 0
STAT5 Activation R-HSA-9645135 6.055540e-01 0.218 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.055540e-01 0.218 0 0
MET Receptor Activation R-HSA-6806942 6.055540e-01 0.218 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.055540e-01 0.218 0 0
Lactose synthesis R-HSA-5653890 6.055540e-01 0.218 0 0
Neurofascin interactions R-HSA-447043 6.055540e-01 0.218 0 0
TBC/RABGAPs R-HSA-8854214 6.058857e-01 0.218 0 0
TCR signaling R-HSA-202403 6.064319e-01 0.217 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.095449e-01 0.215 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.116501e-01 0.213 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.116501e-01 0.213 0 0
Translesion synthesis by POLI R-HSA-5656121 6.119192e-01 0.213 0 0
Phosphorylation of the APC/C R-HSA-176412 6.119192e-01 0.213 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.119192e-01 0.213 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.119192e-01 0.213 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.119192e-01 0.213 0 0
Attachment and Entry R-HSA-9678110 6.119192e-01 0.213 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.119192e-01 0.213 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.119192e-01 0.213 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.119192e-01 0.213 0 0
Activation of SMO R-HSA-5635838 6.119192e-01 0.213 0 0
IGF1R signaling cascade R-HSA-2428924 6.140543e-01 0.212 0 0
Insulin receptor signalling cascade R-HSA-74751 6.140543e-01 0.212 0 0
Integration of energy metabolism R-HSA-163685 6.154381e-01 0.211 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.165865e-01 0.210 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.165865e-01 0.210 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.210425e-01 0.207 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.210425e-01 0.207 0 0
HDMs demethylate histones R-HSA-3214842 6.210425e-01 0.207 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.246295e-01 0.204 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.247929e-01 0.204 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.282336e-01 0.202 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.320351e-01 0.199 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.374369e-01 0.196 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.382536e-01 0.195 0 0
Translesion synthesis by POLK R-HSA-5655862 6.382536e-01 0.195 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.382536e-01 0.195 0 0
Synthesis of PG R-HSA-1483148 6.382536e-01 0.195 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.382536e-01 0.195 0 0
Response to metal ions R-HSA-5660526 6.382536e-01 0.195 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.392285e-01 0.194 0 0
MET activates PTK2 signaling R-HSA-8874081 6.421802e-01 0.192 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.421802e-01 0.192 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.421802e-01 0.192 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.433291e-01 0.192 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.436828e-01 0.191 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.443004e-01 0.191 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.443004e-01 0.191 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.443004e-01 0.191 0 0
Disinhibition of SNARE formation R-HSA-114516 6.443004e-01 0.191 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.443004e-01 0.191 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.443004e-01 0.191 0 0
VLDL clearance R-HSA-8964046 6.443004e-01 0.191 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.443004e-01 0.191 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.443004e-01 0.191 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.468069e-01 0.189 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.476409e-01 0.189 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.476409e-01 0.189 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.483957e-01 0.188 0 0
RNA Polymerase III Transcription R-HSA-74158 6.483957e-01 0.188 0 0
Triglyceride catabolism R-HSA-163560 6.483957e-01 0.188 0 0
Diseases of DNA repair R-HSA-9675135 6.552272e-01 0.184 0 0
Cardiac conduction R-HSA-5576891 6.556689e-01 0.183 0 0
Pyruvate metabolism R-HSA-70268 6.587736e-01 0.181 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.624721e-01 0.179 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.624721e-01 0.179 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.624721e-01 0.179 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.624721e-01 0.179 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.624721e-01 0.179 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.631614e-01 0.178 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.631614e-01 0.178 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.631614e-01 0.178 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.631614e-01 0.178 0 0
Degradation of DVL R-HSA-4641258 6.658783e-01 0.177 0 0
Regulated Necrosis R-HSA-5218859 6.689549e-01 0.175 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.755783e-01 0.170 0 0
Dual incision in TC-NER R-HSA-6782135 6.762293e-01 0.170 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.792429e-01 0.168 0 0
Regulation by c-FLIP R-HSA-3371378 6.792429e-01 0.168 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.792429e-01 0.168 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.792429e-01 0.168 0 0
Dimerization of procaspase-8 R-HSA-69416 6.792429e-01 0.168 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.792429e-01 0.168 0 0
MET receptor recycling R-HSA-8875656 6.792429e-01 0.168 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.792429e-01 0.168 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.792429e-01 0.168 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.792429e-01 0.168 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.792429e-01 0.168 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.792429e-01 0.168 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.792429e-01 0.168 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.792429e-01 0.168 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.792429e-01 0.168 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.792429e-01 0.168 0 0
Alpha-defensins R-HSA-1462054 6.792429e-01 0.168 0 0
Modulation by Mtb of host immune system R-HSA-9637628 6.792429e-01 0.168 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.818973e-01 0.166 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.819151e-01 0.166 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.819151e-01 0.166 0 0
HIV elongation arrest and recovery R-HSA-167287 6.819151e-01 0.166 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.819151e-01 0.166 0 0
GPER1 signaling R-HSA-9634597 6.858321e-01 0.164 0 0
Gluconeogenesis R-HSA-70263 6.858321e-01 0.164 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.866686e-01 0.163 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.866686e-01 0.163 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.866686e-01 0.163 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.866686e-01 0.163 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.866686e-01 0.163 0 0
Mismatch Repair R-HSA-5358508 6.866686e-01 0.163 0 0
Tie2 Signaling R-HSA-210993 6.866686e-01 0.163 0 0
G1/S Transition R-HSA-69206 6.868818e-01 0.163 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.941586e-01 0.159 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.945143e-01 0.158 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.990266e-01 0.156 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.004263e-01 0.155 0 0
Signaling by Erythropoietin R-HSA-9006335 7.005112e-01 0.155 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.005112e-01 0.155 0 0
Late endosomal microautophagy R-HSA-9615710 7.005112e-01 0.155 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.005112e-01 0.155 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.005112e-01 0.155 0 0
Platelet calcium homeostasis R-HSA-418360 7.005112e-01 0.155 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.005112e-01 0.155 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.041635e-01 0.152 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.088100e-01 0.149 0 0
Specification of the neural plate border R-HSA-9834899 7.088100e-01 0.149 0 0
Maturation of nucleoprotein R-HSA-9694631 7.088100e-01 0.149 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.107546e-01 0.148 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.107546e-01 0.148 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.107546e-01 0.148 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.107546e-01 0.148 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.107546e-01 0.148 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.145439e-01 0.146 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.146876e-01 0.146 0 0
Interleukin-2 family signaling R-HSA-451927 7.146876e-01 0.146 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.161604e-01 0.145 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.182675e-01 0.144 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.182675e-01 0.144 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.182675e-01 0.144 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.182675e-01 0.144 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.182675e-01 0.144 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.182675e-01 0.144 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.187563e-01 0.143 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.266543e-01 0.139 0 0
Signaling by Hedgehog R-HSA-5358351 7.280459e-01 0.138 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.281837e-01 0.138 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.296271e-01 0.137 0 0
Glycogen synthesis R-HSA-3322077 7.296271e-01 0.137 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.297413e-01 0.137 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.303760e-01 0.136 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.351948e-01 0.134 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.351948e-01 0.134 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.351948e-01 0.134 0 0
2-LTR circle formation R-HSA-164843 7.391722e-01 0.131 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.391722e-01 0.131 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.391722e-01 0.131 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.391722e-01 0.131 0 0
Maturation of spike protein R-HSA-9683686 7.391722e-01 0.131 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.391722e-01 0.131 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.391722e-01 0.131 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.408186e-01 0.130 0 0
Signaling by NOTCH4 R-HSA-9013694 7.416598e-01 0.130 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.421040e-01 0.130 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.441919e-01 0.128 0 0
Translation of Structural Proteins R-HSA-9683701 7.441919e-01 0.128 0 0
Lagging Strand Synthesis R-HSA-69186 7.491662e-01 0.125 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.491662e-01 0.125 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.491662e-01 0.125 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.491662e-01 0.125 0 0
G0 and Early G1 R-HSA-1538133 7.513075e-01 0.124 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.526073e-01 0.123 0 0
Circadian clock R-HSA-9909396 7.571798e-01 0.121 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.647993e-01 0.116 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.647993e-01 0.116 0 0
LGI-ADAM interactions R-HSA-5682910 7.647993e-01 0.116 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.647993e-01 0.116 0 0
vRNP Assembly R-HSA-192905 7.647993e-01 0.116 0 0
vRNA Synthesis R-HSA-192814 7.647993e-01 0.116 0 0
Synthesis of PI R-HSA-1483226 7.647993e-01 0.116 0 0
Bicarbonate transporters R-HSA-425381 7.647993e-01 0.116 0 0
Transport of RCbl within the body R-HSA-9758890 7.647993e-01 0.116 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.647993e-01 0.116 0 0
Prostanoid ligand receptors R-HSA-391908 7.647993e-01 0.116 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.647993e-01 0.116 0 0
Nucleotide Excision Repair R-HSA-5696398 7.663588e-01 0.116 0 0
Nuclear RNA decay R-HSA-9930044 7.666229e-01 0.115 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.666229e-01 0.115 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.666229e-01 0.115 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.674776e-01 0.115 0 0
Attachment and Entry R-HSA-9694614 7.674776e-01 0.115 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.674776e-01 0.115 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.674776e-01 0.115 0 0
Ribavirin ADME R-HSA-9755088 7.674776e-01 0.115 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.683349e-01 0.114 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.739118e-01 0.111 0 0
Interferon alpha/beta signaling R-HSA-909733 7.766516e-01 0.110 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.811607e-01 0.107 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.811607e-01 0.107 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.811607e-01 0.107 0 0
Cellular response to chemical stress R-HSA-9711123 7.814358e-01 0.107 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.828286e-01 0.106 0 0
Cyclin D associated events in G1 R-HSA-69231 7.839986e-01 0.106 0 0
G1 Phase R-HSA-69236 7.839986e-01 0.106 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.846138e-01 0.105 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.846138e-01 0.105 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.846138e-01 0.105 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.846138e-01 0.105 0 0
LDL clearance R-HSA-8964038 7.846138e-01 0.105 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.846138e-01 0.105 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.879099e-01 0.104 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.879099e-01 0.104 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.879099e-01 0.104 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.879099e-01 0.104 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.879099e-01 0.104 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.879099e-01 0.104 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.879099e-01 0.104 0 0
Sodium/Calcium exchangers R-HSA-425561 7.879099e-01 0.104 0 0
Integration of provirus R-HSA-162592 7.879099e-01 0.104 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.892931e-01 0.103 0 0
Stimuli-sensing channels R-HSA-2672351 7.918237e-01 0.101 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.949427e-01 0.100 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.949427e-01 0.100 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.961187e-01 0.099 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.961187e-01 0.099 0 0
IRS-mediated signalling R-HSA-112399 8.001312e-01 0.097 0 0
Synthesis of PA R-HSA-1483166 8.001312e-01 0.097 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.006289e-01 0.097 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.006289e-01 0.097 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.006289e-01 0.097 0 0
Carnitine shuttle R-HSA-200425 8.006289e-01 0.097 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.076846e-01 0.093 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.076846e-01 0.093 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.079920e-01 0.093 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.079920e-01 0.093 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.087509e-01 0.092 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.087509e-01 0.092 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.087509e-01 0.092 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.087509e-01 0.092 0 0
Acetylation R-HSA-156582 8.087509e-01 0.092 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.087509e-01 0.092 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.087509e-01 0.092 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.087509e-01 0.092 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.087509e-01 0.092 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.087509e-01 0.092 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.087509e-01 0.092 0 0
Interleukin-15 signaling R-HSA-8983432 8.087509e-01 0.092 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.155777e-01 0.089 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.155777e-01 0.089 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.203333e-01 0.086 0 0
Signaling by Insulin receptor R-HSA-74752 8.254079e-01 0.083 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.275450e-01 0.082 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.275450e-01 0.082 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.275450e-01 0.082 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.275450e-01 0.082 0 0
Processing of SMDT1 R-HSA-8949664 8.275450e-01 0.082 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.275450e-01 0.082 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.275450e-01 0.082 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.275450e-01 0.082 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.275450e-01 0.082 0 0
Interleukin-6 signaling R-HSA-1059683 8.275450e-01 0.082 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.275450e-01 0.082 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.275450e-01 0.082 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.295150e-01 0.081 0 0
Laminin interactions R-HSA-3000157 8.295150e-01 0.081 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.295150e-01 0.081 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.319919e-01 0.080 0 0
Voltage gated Potassium channels R-HSA-1296072 8.319919e-01 0.080 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.319919e-01 0.080 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.357523e-01 0.078 0 0
Immune System R-HSA-168256 8.360428e-01 0.078 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.424954e-01 0.074 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.424954e-01 0.074 0 0
Elastic fibre formation R-HSA-1566948 8.429939e-01 0.074 0 0
Removal of the Flap Intermediate R-HSA-69166 8.444933e-01 0.073 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.444933e-01 0.073 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.444933e-01 0.073 0 0
cGMP effects R-HSA-418457 8.444933e-01 0.073 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.444933e-01 0.073 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.444933e-01 0.073 0 0
Hydrolysis of LPC R-HSA-1483115 8.444933e-01 0.073 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.444933e-01 0.073 0 0
Physiological factors R-HSA-5578768 8.444933e-01 0.073 0 0
Malate-aspartate shuttle R-HSA-9856872 8.444933e-01 0.073 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.444933e-01 0.073 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.444933e-01 0.073 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.444933e-01 0.073 0 0
Signaling by PDGF R-HSA-186797 8.478384e-01 0.072 0 0
PI3K Cascade R-HSA-109704 8.486909e-01 0.071 0 0
Signaling by FGFR in disease R-HSA-1226099 8.490682e-01 0.071 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.533657e-01 0.069 0 0
Cristae formation R-HSA-8949613 8.545721e-01 0.068 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.545721e-01 0.068 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.545721e-01 0.068 0 0
Insulin processing R-HSA-264876 8.545721e-01 0.068 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.567617e-01 0.067 0 0
The phototransduction cascade R-HSA-2514856 8.577059e-01 0.067 0 0
Developmental Cell Lineages R-HSA-9734767 8.594708e-01 0.066 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.597768e-01 0.066 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.597768e-01 0.066 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.597768e-01 0.066 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.597768e-01 0.066 0 0
Protein lipoylation R-HSA-9857492 8.597768e-01 0.066 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.597768e-01 0.066 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.597768e-01 0.066 0 0
DNA Damage Reversal R-HSA-73942 8.597768e-01 0.066 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.597768e-01 0.066 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.597768e-01 0.066 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.597768e-01 0.066 0 0
Other semaphorin interactions R-HSA-416700 8.597768e-01 0.066 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.612944e-01 0.065 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.631340e-01 0.064 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.631340e-01 0.064 0 0
HIV Transcription Elongation R-HSA-167169 8.631340e-01 0.064 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.631340e-01 0.064 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.631340e-01 0.064 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.631340e-01 0.064 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.631340e-01 0.064 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.631340e-01 0.064 0 0
Glycogen metabolism R-HSA-8982491 8.631340e-01 0.064 0 0
Synthesis of DNA R-HSA-69239 8.644185e-01 0.063 0 0
Telomere Extension By Telomerase R-HSA-171319 8.657973e-01 0.063 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.657973e-01 0.063 0 0
Pyroptosis R-HSA-5620971 8.657973e-01 0.063 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.662588e-01 0.062 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.662588e-01 0.062 0 0
Orc1 removal from chromatin R-HSA-68949 8.662588e-01 0.062 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.680515e-01 0.061 0 0
Toll-like Receptor Cascades R-HSA-168898 8.720531e-01 0.059 0 0
Interferon gamma signaling R-HSA-877300 8.729652e-01 0.059 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.735591e-01 0.059 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.735591e-01 0.059 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.735591e-01 0.059 0 0
Regulation of BACH1 activity R-HSA-9708530 8.735591e-01 0.059 0 0
Regulation of insulin secretion R-HSA-422356 8.738704e-01 0.059 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.743665e-01 0.058 0 0
mRNA Capping R-HSA-72086 8.762219e-01 0.057 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.762219e-01 0.057 0 0
DARPP-32 events R-HSA-180024 8.762219e-01 0.057 0 0
Integrin cell surface interactions R-HSA-216083 8.779232e-01 0.057 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.809657e-01 0.055 0 0
HIV Transcription Initiation R-HSA-167161 8.809657e-01 0.055 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.809657e-01 0.055 0 0
Intra-Golgi traffic R-HSA-6811438 8.809657e-01 0.055 0 0
Neurotransmitter clearance R-HSA-112311 8.858946e-01 0.053 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.858946e-01 0.053 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.859874e-01 0.053 0 0
Glycine degradation R-HSA-6783984 8.859874e-01 0.053 0 0
Phase 2 - plateau phase R-HSA-5576893 8.859874e-01 0.053 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.859874e-01 0.053 0 0
Fibronectin matrix formation R-HSA-1566977 8.859874e-01 0.053 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.859874e-01 0.053 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.859874e-01 0.053 0 0
Passive transport by Aquaporins R-HSA-432047 8.859874e-01 0.053 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.859874e-01 0.053 0 0
Galactose catabolism R-HSA-70370 8.859874e-01 0.053 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.859874e-01 0.053 0 0
G alpha (z) signalling events R-HSA-418597 8.893132e-01 0.051 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.893132e-01 0.051 0 0
Interleukin-1 signaling R-HSA-9020702 8.909663e-01 0.050 0 0
Adipogenesis R-HSA-9843745 8.915751e-01 0.050 0 0
Transcription of the HIV genome R-HSA-167172 8.922242e-01 0.050 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.948625e-01 0.048 0 0
Budding and maturation of HIV virion R-HSA-162588 8.948625e-01 0.048 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.948625e-01 0.048 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.961859e-01 0.048 0 0
PI Metabolism R-HSA-1483255 8.962169e-01 0.048 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.966984e-01 0.047 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.971948e-01 0.047 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.971948e-01 0.047 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.971948e-01 0.047 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.971948e-01 0.047 0 0
Choline catabolism R-HSA-6798163 8.971948e-01 0.047 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.971948e-01 0.047 0 0
Glycogen storage diseases R-HSA-3229121 8.971948e-01 0.047 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.971948e-01 0.047 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.011328e-01 0.045 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.031706e-01 0.044 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.031706e-01 0.044 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.062146e-01 0.043 0 0
PKA activation in glucagon signalling R-HSA-164378 9.073011e-01 0.042 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.073011e-01 0.042 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.073011e-01 0.042 0 0
PKA activation R-HSA-163615 9.073011e-01 0.042 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.073011e-01 0.042 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.088128e-01 0.042 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.096725e-01 0.041 0 0
Hedgehog 'on' state R-HSA-5632684 9.098896e-01 0.041 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.105344e-01 0.041 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.105344e-01 0.041 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.105344e-01 0.041 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.105344e-01 0.041 0 0
RSV-host interactions R-HSA-9833110 9.107088e-01 0.041 0 0
Cardiogenesis R-HSA-9733709 9.108621e-01 0.041 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.108621e-01 0.041 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.143836e-01 0.039 0 0
Triglyceride metabolism R-HSA-8979227 9.145994e-01 0.039 0 0
Regulation of beta-cell development R-HSA-186712 9.145994e-01 0.039 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.145994e-01 0.039 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.164145e-01 0.038 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.164145e-01 0.038 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.164145e-01 0.038 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.164145e-01 0.038 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.168017e-01 0.038 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.168017e-01 0.038 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.179777e-01 0.037 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.179777e-01 0.037 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.179777e-01 0.037 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.200559e-01 0.036 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.218669e-01 0.035 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.226661e-01 0.035 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.229508e-01 0.035 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.245564e-01 0.034 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.245564e-01 0.034 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.245564e-01 0.034 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.245564e-01 0.034 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.246323e-01 0.034 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.246323e-01 0.034 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.246323e-01 0.034 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.246323e-01 0.034 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.246323e-01 0.034 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.246323e-01 0.034 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.246323e-01 0.034 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.246323e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.246323e-01 0.034 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.273184e-01 0.033 0 0
Mitochondrial protein import R-HSA-1268020 9.300398e-01 0.031 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.300398e-01 0.031 0 0
Regulation of Apoptosis R-HSA-169911 9.306348e-01 0.031 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.306348e-01 0.031 0 0
G-protein activation R-HSA-202040 9.320427e-01 0.031 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.320427e-01 0.031 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.320427e-01 0.031 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.320427e-01 0.031 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.320427e-01 0.031 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.320427e-01 0.031 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.320427e-01 0.031 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.320427e-01 0.031 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.320427e-01 0.031 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.320427e-01 0.031 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.320427e-01 0.031 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.320427e-01 0.031 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.332739e-01 0.030 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.332739e-01 0.030 0 0
Translation of Structural Proteins R-HSA-9694635 9.377562e-01 0.028 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.380592e-01 0.028 0 0
Azathioprine ADME R-HSA-9748787 9.380592e-01 0.028 0 0
ER-Phagosome pathway R-HSA-1236974 9.381160e-01 0.028 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.387248e-01 0.027 0 0
Assembly Of The HIV Virion R-HSA-175474 9.387248e-01 0.027 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.387248e-01 0.027 0 0
Serine metabolism R-HSA-977347 9.387248e-01 0.027 0 0
Metabolism of folate and pterines R-HSA-196757 9.414282e-01 0.026 0 0
Downstream TCR signaling R-HSA-202424 9.416768e-01 0.026 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.447503e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.447503e-01 0.025 0 0
Cellular hexose transport R-HSA-189200 9.447503e-01 0.025 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.447503e-01 0.025 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.462066e-01 0.024 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.466910e-01 0.024 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.466972e-01 0.024 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.493483e-01 0.023 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.501836e-01 0.022 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.501836e-01 0.022 0 0
Formation of the ureteric bud R-HSA-9830674 9.501836e-01 0.022 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.501836e-01 0.022 0 0
Interleukin-20 family signaling R-HSA-8854691 9.501836e-01 0.022 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.505743e-01 0.022 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.505743e-01 0.022 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.506120e-01 0.022 0 0
Stabilization of p53 R-HSA-69541 9.506120e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.507118e-01 0.022 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.517575e-01 0.021 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.541924e-01 0.020 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.549547e-01 0.020 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.550828e-01 0.020 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.550828e-01 0.020 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.550828e-01 0.020 0 0
Complex III assembly R-HSA-9865881 9.550828e-01 0.020 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.550828e-01 0.020 0 0
Interleukin-6 family signaling R-HSA-6783589 9.550828e-01 0.020 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.550828e-01 0.020 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.576252e-01 0.019 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.584106e-01 0.018 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.584106e-01 0.018 0 0
Maturation of spike protein R-HSA-9694548 9.584106e-01 0.018 0 0
G protein gated Potassium channels R-HSA-1296059 9.595005e-01 0.018 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.595005e-01 0.018 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.595005e-01 0.018 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.595005e-01 0.018 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.595005e-01 0.018 0 0
Formation of the nephric duct R-HSA-9830364 9.595005e-01 0.018 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.595005e-01 0.018 0 0
Mitochondrial biogenesis R-HSA-1592230 9.599091e-01 0.018 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.606973e-01 0.017 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.618529e-01 0.017 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.618529e-01 0.017 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.618529e-01 0.017 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.623938e-01 0.017 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.623938e-01 0.017 0 0
ECM proteoglycans R-HSA-3000178 9.623938e-01 0.017 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.634839e-01 0.016 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.634839e-01 0.016 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.634839e-01 0.016 0 0
Potassium Channels R-HSA-1296071 9.641712e-01 0.016 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.649667e-01 0.015 0 0
Activation of GABAB receptors R-HSA-991365 9.650208e-01 0.015 0 0
GABA B receptor activation R-HSA-977444 9.650208e-01 0.015 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.650208e-01 0.015 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.663265e-01 0.015 0 0
Signaling by BMP R-HSA-201451 9.670758e-01 0.015 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.670758e-01 0.015 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.670758e-01 0.015 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.674468e-01 0.014 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.679347e-01 0.014 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.680220e-01 0.014 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.683896e-01 0.014 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.689605e-01 0.014 0 0
Insulin receptor recycling R-HSA-77387 9.703145e-01 0.013 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.706141e-01 0.013 0 0
RAB geranylgeranylation R-HSA-8873719 9.711885e-01 0.013 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.730769e-01 0.012 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.730769e-01 0.012 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.730769e-01 0.012 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.730769e-01 0.012 0 0
Formation of the cornified envelope R-HSA-6809371 9.730956e-01 0.012 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.732348e-01 0.012 0 0
Thyroxine biosynthesis R-HSA-209968 9.732348e-01 0.012 0 0
Glucagon-type ligand receptors R-HSA-420092 9.732348e-01 0.012 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.732348e-01 0.012 0 0
Aquaporin-mediated transport R-HSA-445717 9.733626e-01 0.012 0 0
G alpha (s) signalling events R-HSA-418555 9.750357e-01 0.011 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.755454e-01 0.011 0 0
Metabolism of proteins R-HSA-392499 9.763140e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.774180e-01 0.010 0 0
Gastrulation R-HSA-9758941 9.776593e-01 0.010 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.782423e-01 0.010 0 0
DAG1 glycosylations R-HSA-8931838 9.803831e-01 0.009 0 0
Cellular response to hypoxia R-HSA-1234174 9.805974e-01 0.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.810615e-01 0.008 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.810777e-01 0.008 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.810777e-01 0.008 0 0
FCGR activation R-HSA-2029481 9.810914e-01 0.008 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.812324e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.823573e-01 0.008 0 0
Post-translational protein modification R-HSA-597592 9.834961e-01 0.007 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.840538e-01 0.007 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.840538e-01 0.007 0 0
Heme degradation R-HSA-189483 9.840538e-01 0.007 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.841591e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.841591e-01 0.007 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.856230e-01 0.006 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.856230e-01 0.006 0 0
COPII-mediated vesicle transport R-HSA-204005 9.870273e-01 0.006 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.870380e-01 0.006 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.870380e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.870380e-01 0.006 0 0
Metabolism of cofactors R-HSA-8978934 9.880403e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.881193e-01 0.005 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.883137e-01 0.005 0 0
G1/S-Specific Transcription R-HSA-69205 9.883137e-01 0.005 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.883137e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.885884e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.885884e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.889266e-01 0.005 0 0
Degradation of AXIN R-HSA-4641257 9.894640e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.894640e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.894640e-01 0.005 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.902307e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.903045e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.905011e-01 0.004 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.905011e-01 0.004 0 0
G alpha (q) signalling events R-HSA-416476 9.906533e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.907528e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.914361e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.914361e-01 0.004 0 0
RAS processing R-HSA-9648002 9.914361e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.915440e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.922792e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.922792e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.922836e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.922836e-01 0.003 0 0
GABA receptor activation R-HSA-977443 9.929530e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.930393e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.930393e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.931204e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.931856e-01 0.003 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.932764e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.932764e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.935655e-01 0.003 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.937246e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.937246e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.943425e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.943425e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.946380e-01 0.002 0 0
Defensins R-HSA-1461973 9.948996e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.954019e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.954019e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.956300e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.958547e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.962836e-01 0.002 0 0
Kidney development R-HSA-9830369 9.962836e-01 0.002 0 0
Protein localization R-HSA-9609507 9.965578e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.966104e-01 0.001 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.966310e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.969854e-01 0.001 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.971813e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.973620e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.974302e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.975317e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.975358e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.977551e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.977551e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.980541e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.981917e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.982268e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.983699e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.985398e-01 0.001 0 0
Neddylation R-HSA-8951664 9.985913e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.986593e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.986593e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986753e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.987190e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.988740e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.989874e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.991253e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.991606e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.992055e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.992115e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992172e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.993784e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994225e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.994240e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995770e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.996902e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997208e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997208e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997483e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997732e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997850e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998202e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998615e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998651e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998692e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998784e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998846e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998903e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998928e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999304e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999563e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999570e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999718e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999762e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999831e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999848e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999868e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999876e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999898e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999922e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999927e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999961e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999965e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999965e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999972e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999988e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999989e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999990e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999991e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999993e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999995e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999998e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways