COT

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14757 S345 EPSD|PSP CHEK1 CHK1 LsLWDtsPsYIDKLVQGISFsQPTCPDHMLLNSQLLGTPGS
O43399 S152 Sugiyama TPD52L2 TLsQAGQKtsAALstVGsAIsRKLGDMRNsAtFKsFEDRVG
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95757 S587 Sugiyama HSPA4L APG1 HSPH3 OSP94 RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
P00519 T735 EPSD|PSP ABL1 ABL JTK7 RsCsAsCVPHGAKDTEWRSVtLPRDLQStGRQFDSstFGGH
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P06493 T161 EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 tIKLADFGLARAFGIPIRVytHEVVTLWYRSPEVLLGsARY
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06748 T199 EPSD|PSP NPM1 NPM DDFDDEEAEEKAPVKKsIRDtPAKNAQKSNQNGKDsKPsst
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11142 S544 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KYKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKIND
P11142 S85 Sugiyama HSPA8 HSC70 HSP73 HSPA10 NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P15311 T567 EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15531 S125 Sugiyama NME1 NDPKA NM23 RGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDyTsC
P16220 S119 PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P20810 S379 Sugiyama CAST KPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTEESKAAA
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24752 S218 Sugiyama ACAT1 ACAT MAT ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T558 EPSD|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P33778 S33 EPSD H2BC3 H2BFF HIST1H2BB KGsKKAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDT
P35241 T564 EPSD|PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35269 S398 Sugiyama GTF2F1 RAP74 GGSSRGNsRPGtPsAEGGstsstLRAAASKLEQGKRVSEMP
P36507 S222 SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K2 MEK2 MKK2 PRKMK2 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGT
P36507 S226 SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P39019 T55 Sugiyama RPS19 DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41279 S141 Sugiyama MAP3K8 COT ESTF YQIDSDVLLIPWKLTYRNIGsDFIPRGAFGKVYLAQDIKTK
P41279 S246 Sugiyama MAP3K8 COT ESTF REFEIIWVTKHVLKGLDFLHsKKVIHHDIKPSNIVFMSTKA
P41279 S358 Sugiyama MAP3K8 COT ESTF SYLYIIHKQAPPLEDIADDCsPGMRELIEAsLERNPNHRPR
P41279 S368 Sugiyama MAP3K8 COT ESTF PPLEDIADDCsPGMRELIEAsLERNPNHRPRAADLLKHEAL
P46734 S218 EPSD|PSP MAP2K3 MEK3 MKK3 PRKMK3 SKK2 INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P46937 S406 Sugiyama YAP1 YAP65 LNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEMDTG
P52564 S207 EPSD|PSP MAP2K6 MEK6 MKK6 PRKMK6 SKK3 INALGQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINP
P53350 S137 EPSD|PSP PLK1 PLK HGFFEDNDFVFVVLELCRRRsLLELHKRRKALTEPEARYYL
P53350 T210 SIGNOR|EPSD|PSP PLK1 PLK VKIGDFGLATKVEYDGERKKtLCGtPNyIAPEVLSKKGHSF
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 S150 Sugiyama RAN ARA24 OK/SW-cl.81 KVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARKLIG
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S31 Sugiyama RPS21 LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q02750 S218 SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K1 MEK1 PRKMK1 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGT
Q02750 S222 SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q02750 S244 SIGNOR MAP2K1 MEK1 PRKMK1 VGtRSYMsPERLQGTHYSVQsDIWsMGLsLVEMAVGRYPIP
Q02750 S248 SIGNOR MAP2K1 MEK1 PRKMK1 SYMsPERLQGTHYSVQsDIWsMGLsLVEMAVGRYPIPPPDA
Q04637 S1147 EPSD|PSP EIF4G1 EIF4F EIF4G EIF4GI QQAVPtEsTDNRRVVQRssLsRERGEKAGDRGDRLERSERG
Q05682 S129 Sugiyama CALD1 CAD CDM KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q07065 T471 Sugiyama CKAP4 LQGRLEGLGssEADQDGLAStVRSLGETQLVLYGDVEELKR
Q13541 T70 EPSD|PSP EIF4EBP1 tRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPssDEPP
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q14247 T328 Sugiyama CTTN EMS1 GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q14653 S123 PSP IRF3 PHKIYEFVNSGVGDFSQPDTsPDTNGGGSTSDtQEDILDEL
Q14653 S173 PSP IRF3 PDPGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLK
Q14653 S175 PSP IRF3 PGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRL
Q14653 S188 PSP IRF3 PQPLRsPsLDNPtPFPNLGPsENPLKRLLVPGEEWEFEVtA
Q14653 T180 PSP IRF3 LAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLKRLLVPGE
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q15418 S380 EPSD|PSP RPS6KA1 MAPKAPK1A RSK1 PKDsPGIPPsAGAHQLFRGFsFVAtGLMEDDGKPRAPQAPL
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q8N6T3 S277 Sugiyama ARFGAP1 ARF1GAP EKVKEGKIFDDVSsGVsQLAsKVQGVGSKGWRDVttFFsGK
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q969M3 S45 Sugiyama YIPF5 FINGER5 YIP1A PP12723 SB140 UNQ3123/PRO10275 SYDYGGSGGPYSKQYAGyDysQQGRFVPPDMMQPQQPYTGQ
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99558 T559 SIGNOR|iPTMNet|EPSD MAP3K14 NIK VCLQPDGLGKSLLTGDYIPGtETHMAPEVVLGRSCDAKVDV
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.045974e-11 10.980 0 0
Cellular response to heat stress R-HSA-3371556 3.088198e-09 8.510 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.104036e-08 7.957 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.667476e-08 7.778 0 0
mRNA Splicing R-HSA-72172 3.097428e-08 7.509 0 0
HSF1-dependent transactivation R-HSA-3371571 5.260677e-07 6.279 0 0
Apoptotic execution phase R-HSA-75153 5.325854e-07 6.274 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.134028e-07 6.212 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.081087e-07 6.150 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.229327e-06 5.910 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.751938e-06 5.756 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.066221e-06 5.513 0 0
Metabolism of RNA R-HSA-8953854 4.845999e-06 5.315 0 0
Chromatin organization R-HSA-4839726 1.209353e-05 4.917 0 0
Regulation of KIT signaling R-HSA-1433559 1.311971e-05 4.882 0 0
Attenuation phase R-HSA-3371568 1.936011e-05 4.713 0 0
Cell Cycle R-HSA-1640170 2.062596e-05 4.686 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.702335e-05 4.568 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.579435e-05 4.446 0 0
Cell Cycle, Mitotic R-HSA-69278 3.664636e-05 4.436 0 0
M Phase R-HSA-68886 5.075281e-05 4.295 0 0
Chromatin modifying enzymes R-HSA-3247509 9.516485e-05 4.022 0 0
HSF1 activation R-HSA-3371511 9.918720e-05 4.004 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.210285e-04 3.917 0 0
Mitotic Prometaphase R-HSA-68877 1.286110e-04 3.891 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.381308e-04 3.860 0 0
Signal Transduction R-HSA-162582 1.527923e-04 3.816 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.760879e-04 3.754 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.457233e-04 3.610 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.696998e-04 3.569 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.133218e-04 3.504 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.133218e-04 3.504 0 0
mRNA 3'-end processing R-HSA-72187 3.089274e-04 3.510 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.089274e-04 3.510 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.447574e-04 3.462 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.638916e-04 3.439 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.688505e-04 3.433 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.864562e-04 3.413 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.170498e-04 3.380 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.170498e-04 3.380 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.306049e-04 3.366 0 0
Ephrin signaling R-HSA-3928664 4.648208e-04 3.333 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.699478e-04 3.328 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.965205e-04 3.304 0 0
Mitotic Anaphase R-HSA-68882 5.286931e-04 3.277 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.291538e-04 3.276 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.722545e-04 3.242 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.176195e-04 3.209 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.461337e-04 3.190 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.130654e-04 3.147 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.841888e-04 3.106 0 0
Gene expression (Transcription) R-HSA-74160 7.590128e-04 3.120 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.684034e-04 3.114 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.684034e-04 3.114 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.841888e-04 3.106 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.841888e-04 3.106 0 0
Nuclear import of Rev protein R-HSA-180746 7.625634e-04 3.118 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.348877e-04 3.029 0 0
TGFBR3 expression R-HSA-9839394 1.000626e-03 3.000 0 0
Long-term potentiation R-HSA-9620244 1.000626e-03 3.000 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.195567e-03 2.922 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.321219e-03 2.879 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.430580e-03 2.844 0 0
Signaling by Hippo R-HSA-2028269 1.494686e-03 2.825 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.544547e-03 2.811 0 0
Signaling by ALK in cancer R-HSA-9700206 1.544547e-03 2.811 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.654323e-03 2.781 0 0
Signaling by SCF-KIT R-HSA-1433557 1.608958e-03 2.793 0 0
Death Receptor Signaling R-HSA-73887 1.618097e-03 2.791 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.784310e-03 2.749 0 0
Separation of Sister Chromatids R-HSA-2467813 1.952062e-03 2.710 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.001616e-03 2.699 0 0
HIV Life Cycle R-HSA-162587 2.081252e-03 2.682 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.980431e-03 2.703 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.291670e-03 2.640 0 0
PECAM1 interactions R-HSA-210990 2.570242e-03 2.590 0 0
snRNP Assembly R-HSA-191859 2.549158e-03 2.594 0 0
Metabolism of non-coding RNA R-HSA-194441 2.549158e-03 2.594 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.616888e-03 2.582 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.784184e-03 2.555 0 0
Signaling by ERBB2 R-HSA-1227986 2.920615e-03 2.535 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.999135e-03 2.523 0 0
Membrane Trafficking R-HSA-199991 3.003195e-03 2.522 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.502738e-03 2.456 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.502738e-03 2.456 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.937121e-03 2.405 0 0
NRAGE signals death through JNK R-HSA-193648 4.243328e-03 2.372 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.514709e-03 2.345 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.927001e-03 2.307 0 0
Axon guidance R-HSA-422475 5.219643e-03 2.282 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.080745e-03 2.294 0 0
Cell Cycle Checkpoints R-HSA-69620 5.320912e-03 2.274 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.657761e-03 2.247 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.723358e-03 2.242 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.776635e-03 2.238 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.984574e-03 2.223 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.088325e-03 2.216 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.024793e-03 2.153 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.024793e-03 2.153 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.024793e-03 2.153 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.024793e-03 2.153 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.500120e-03 2.125 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.605853e-03 2.119 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.613949e-03 2.118 0 0
Nervous system development R-HSA-9675108 7.648289e-03 2.116 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.802207e-03 2.108 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.802207e-03 2.108 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.990901e-03 2.097 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.899699e-03 2.051 0 0
HIV Infection R-HSA-162906 1.013861e-02 1.994 0 0
Signaling by PTK6 R-HSA-8848021 9.980825e-03 2.001 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.980825e-03 2.001 0 0
Apoptosis R-HSA-109581 9.968194e-03 2.001 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.080991e-02 1.966 0 0
DCC mediated attractive signaling R-HSA-418885 1.080991e-02 1.966 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.080991e-02 1.966 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.160414e-02 1.935 0 0
Mitotic Prophase R-HSA-68875 1.192106e-02 1.924 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.201939e-02 1.920 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.312566e-02 1.882 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.429311e-02 1.845 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.613020e-02 1.792 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.613020e-02 1.792 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.653810e-02 1.782 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.657011e-02 1.781 0 0
Signaling by TGFBR3 R-HSA-9839373 1.682504e-02 1.774 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.772342e-02 1.751 0 0
HIV elongation arrest and recovery R-HSA-167287 1.825262e-02 1.739 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.825262e-02 1.739 0 0
Signaling by VEGF R-HSA-194138 1.853107e-02 1.732 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.919320e-02 1.717 0 0
tRNA processing in the nucleus R-HSA-6784531 1.964150e-02 1.707 0 0
mTORC1-mediated signalling R-HSA-166208 1.973562e-02 1.705 0 0
Regulation of gap junction activity R-HSA-191650 2.061670e-02 1.686 0 0
Type I hemidesmosome assembly R-HSA-446107 2.234328e-02 1.651 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.234328e-02 1.651 0 0
Cellular responses to stress R-HSA-2262752 2.089870e-02 1.680 0 0
HATs acetylate histones R-HSA-3214847 2.193960e-02 1.659 0 0
Cellular responses to stimuli R-HSA-8953897 2.196758e-02 1.658 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.282748e-02 1.642 0 0
MTOR signalling R-HSA-165159 2.448061e-02 1.611 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.486299e-02 1.604 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.486299e-02 1.604 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.512002e-02 1.600 0 0
Cell-Cell communication R-HSA-1500931 2.575693e-02 1.589 0 0
ESR-mediated signaling R-HSA-8939211 2.680348e-02 1.572 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.728571e-02 1.564 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.812908e-02 1.551 0 0
RNA Polymerase II Transcription R-HSA-73857 2.850541e-02 1.545 0 0
Unwinding of DNA R-HSA-176974 2.940716e-02 1.532 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.054615e-02 1.515 0 0
IRS activation R-HSA-74713 3.054615e-02 1.515 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.054615e-02 1.515 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.054615e-02 1.515 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.074248e-02 1.512 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.509669e-02 1.455 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.489185e-02 1.457 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.503117e-02 1.456 0 0
Protein ubiquitination R-HSA-8852135 3.214449e-02 1.493 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.566980e-02 1.448 0 0
Meiotic synapsis R-HSA-1221632 3.597575e-02 1.444 0 0
Nucleotide Excision Repair R-HSA-5696398 3.655257e-02 1.437 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.657032e-02 1.437 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.657032e-02 1.437 0 0
Myogenesis R-HSA-525793 3.659033e-02 1.437 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 3.764444e-02 1.424 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.194109e-02 1.377 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.194109e-02 1.377 0 0
Striated Muscle Contraction R-HSA-390522 4.133387e-02 1.384 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.991587e-02 1.399 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.805639e-02 1.420 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.805639e-02 1.420 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.805639e-02 1.420 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.805639e-02 1.420 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.212950e-02 1.375 0 0
Translation initiation complex formation R-HSA-72649 3.961289e-02 1.402 0 0
EPH-Ephrin signaling R-HSA-2682334 4.042211e-02 1.393 0 0
Signal attenuation R-HSA-74749 3.765123e-02 1.424 0 0
Signaling by RAS mutants R-HSA-6802949 3.805639e-02 1.420 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.194109e-02 1.377 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.764444e-02 1.424 0 0
Gene Silencing by RNA R-HSA-211000 4.180290e-02 1.379 0 0
G alpha (12/13) signalling events R-HSA-416482 4.105585e-02 1.387 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.255915e-02 1.371 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.255915e-02 1.371 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.423186e-02 1.354 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.423186e-02 1.354 0 0
Semaphorin interactions R-HSA-373755 4.423186e-02 1.354 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.449167e-02 1.352 0 0
FLT3 Signaling R-HSA-9607240 4.449167e-02 1.352 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.511449e-02 1.346 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.649021e-02 1.333 0 0
RAF activation R-HSA-5673000 4.649184e-02 1.333 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.649184e-02 1.333 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.708944e-02 1.327 0 0
Programmed Cell Death R-HSA-5357801 4.734998e-02 1.325 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.763672e-02 1.322 0 0
Signaling by EGFR R-HSA-177929 4.763672e-02 1.322 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.770819e-02 1.321 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.770819e-02 1.321 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.770819e-02 1.321 0 0
Host Interactions of HIV factors R-HSA-162909 4.779663e-02 1.321 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.819783e-02 1.317 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.340735e-02 1.272 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.409990e-02 1.267 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.669258e-02 1.246 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.940532e-02 1.306 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.107366e-02 1.292 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.205310e-02 1.284 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.340735e-02 1.272 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.658189e-02 1.247 0 0
Nef and signal transduction R-HSA-164944 5.658189e-02 1.247 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.923404e-02 1.308 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.669867e-02 1.246 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.669867e-02 1.246 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.694413e-02 1.245 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.694413e-02 1.245 0 0
Regulation of TP53 Expression R-HSA-6804754 5.697682e-02 1.244 0 0
RET signaling R-HSA-8853659 5.802482e-02 1.236 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.802482e-02 1.236 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.092452e-02 1.215 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.092452e-02 1.215 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.163112e-02 1.210 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.204162e-02 1.207 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.252634e-02 1.204 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.279678e-02 1.202 0 0
Regulation of TP53 Activity R-HSA-5633007 6.331822e-02 1.198 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.385511e-02 1.195 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.619238e-02 1.179 0 0
Netrin-1 signaling R-HSA-373752 6.623751e-02 1.179 0 0
Kinesins R-HSA-983189 6.683641e-02 1.175 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.683641e-02 1.175 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.797022e-02 1.168 0 0
Trafficking of AMPA receptors R-HSA-399719 6.825266e-02 1.166 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.924499e-02 1.160 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 7.250123e-02 1.140 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.250123e-02 1.140 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.250123e-02 1.140 0 0
SOS-mediated signalling R-HSA-112412 7.250123e-02 1.140 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.951743e-02 1.158 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.245369e-02 1.084 0 0
Regulation of signaling by CBL R-HSA-912631 8.321898e-02 1.080 0 0
Nucleosome assembly R-HSA-774815 7.256068e-02 1.139 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.256068e-02 1.139 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.924461e-02 1.101 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.844852e-02 1.105 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.246731e-02 1.140 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.245369e-02 1.084 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.239685e-02 1.084 0 0
PTEN Regulation R-HSA-6807070 7.901653e-02 1.102 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.951743e-02 1.158 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.256068e-02 1.139 0 0
Influenza Infection R-HSA-168255 7.015288e-02 1.154 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.372614e-02 1.077 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.372614e-02 1.077 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.411587e-02 1.075 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.442390e-02 1.074 0 0
Integrin signaling R-HSA-354192 8.442390e-02 1.074 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.483104e-02 1.071 0 0
HIV Transcription Elongation R-HSA-167169 8.609903e-02 1.065 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.609903e-02 1.065 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.609903e-02 1.065 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.012512e-02 1.045 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.012512e-02 1.045 0 0
Formation of annular gap junctions R-HSA-196025 9.017575e-02 1.045 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.104331e-02 1.041 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.126288e-02 1.040 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.126288e-02 1.040 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.126288e-02 1.040 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.126288e-02 1.040 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.136851e-02 1.039 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.134485e-01 0.945 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.134485e-01 0.945 0 0
Lipophagy R-HSA-9613354 1.094448e-01 0.961 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.094448e-01 0.961 0 0
Gap junction degradation R-HSA-190873 1.094448e-01 0.961 0 0
ALK mutants bind TKIs R-HSA-9700645 1.094448e-01 0.961 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.648075e-02 1.016 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.115421e-01 0.953 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.004656e-01 0.998 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.004656e-01 0.998 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.326272e-02 1.030 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.428372e-02 1.026 0 0
Centrosome maturation R-HSA-380287 1.072813e-01 0.969 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.069488e-01 0.971 0 0
DNA Double Strand Break Response R-HSA-5693606 1.110743e-01 0.954 0 0
Co-stimulation by CD28 R-HSA-389356 9.369682e-02 1.028 1 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.140056e-01 0.943 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.296473e-02 1.032 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.115421e-01 0.953 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.648075e-02 1.016 0 0
Negative regulation of MET activity R-HSA-6807004 9.476344e-02 1.023 0 0
Oncogene Induced Senescence R-HSA-2559585 1.124173e-01 0.949 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.115421e-01 0.953 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.476344e-02 1.023 0 0
G2/M Transition R-HSA-69275 9.456590e-02 1.024 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.004656e-01 0.998 0 0
p75NTR signals via NF-kB R-HSA-193639 1.115421e-01 0.953 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.024537e-01 0.989 0 0
Cell junction organization R-HSA-446728 9.662870e-02 1.015 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.134485e-01 0.945 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.094448e-01 0.961 0 0
Deubiquitination R-HSA-5688426 1.143575e-01 0.942 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.106008e-01 0.956 0 0
Signal regulatory protein family interactions R-HSA-391160 9.648075e-02 1.016 0 0
TNF signaling R-HSA-75893 9.234767e-02 1.035 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.645264e-02 1.016 0 0
IRE1alpha activates chaperones R-HSA-381070 1.116900e-01 0.952 0 0
DNA Repair R-HSA-73894 1.174247e-01 0.930 0 0
Transcription of the HIV genome R-HSA-167172 1.185092e-01 0.926 0 0
Glycolysis R-HSA-70171 1.191560e-01 0.924 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.198471e-01 0.921 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.201294e-01 0.920 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.201294e-01 0.920 0 0
TBC/RABGAPs R-HSA-8854214 1.208599e-01 0.918 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.227141e-01 0.911 0 0
RNA Polymerase III Transcription R-HSA-74158 1.227141e-01 0.911 0 0
FLT3 signaling in disease R-HSA-9682385 1.227141e-01 0.911 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.260625e-01 0.899 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.260625e-01 0.899 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.275726e-01 0.894 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.301357e-01 0.886 0 0
Regulation of CDH11 function R-HSA-9762292 1.301357e-01 0.886 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.301357e-01 0.886 0 0
Josephin domain DUBs R-HSA-5689877 1.301357e-01 0.886 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.301357e-01 0.886 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.303149e-01 0.885 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.319747e-01 0.880 0 0
Rab regulation of trafficking R-HSA-9007101 1.320916e-01 0.879 0 0
FGFR2 alternative splicing R-HSA-6803529 1.338873e-01 0.873 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.338873e-01 0.873 0 0
Signaling by KIT in disease R-HSA-9669938 1.338873e-01 0.873 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.742018e-01 0.759 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.742018e-01 0.759 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.742018e-01 0.759 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.742018e-01 0.759 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.742018e-01 0.759 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.742018e-01 0.759 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.742018e-01 0.759 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.742018e-01 0.759 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.453793e-01 0.837 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.453793e-01 0.837 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.788684e-01 0.747 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.788684e-01 0.747 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.520699e-01 0.818 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.750675e-01 0.757 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.750675e-01 0.757 0 0
Disorders of Developmental Biology R-HSA-9675151 1.445004e-01 0.840 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.445004e-01 0.840 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.622483e-01 0.790 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.622483e-01 0.790 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.483117e-01 0.829 0 0
DAP12 signaling R-HSA-2424491 1.349884e-01 0.870 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.563237e-01 0.806 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.731130e-01 0.762 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.450902e-01 0.838 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.484855e-01 0.828 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.349884e-01 0.870 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.750675e-01 0.757 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.424392e-01 0.846 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.475834e-01 0.831 0 0
Specification of primordial germ cells R-HSA-9827857 1.622483e-01 0.790 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.448862e-01 0.839 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.483117e-01 0.829 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.453793e-01 0.837 0 0
Hydroxycarboxylic acid-binding receptors R-HSA-3296197 1.453793e-01 0.837 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.788684e-01 0.747 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.788684e-01 0.747 0 0
HDACs deacetylate histones R-HSA-3214815 1.553554e-01 0.809 0 0
Signaling by ROBO receptors R-HSA-376176 1.746823e-01 0.758 0 0
Vesicle-mediated transport R-HSA-5653656 1.726225e-01 0.763 0 0
NGF-stimulated transcription R-HSA-9031628 1.731130e-01 0.762 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.445004e-01 0.840 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.633606e-01 0.787 0 0
Neurodegenerative Diseases R-HSA-8863678 1.633606e-01 0.787 0 0
Reelin signalling pathway R-HSA-8866376 1.453793e-01 0.837 0 0
Co-inhibition by BTLA R-HSA-9927353 1.453793e-01 0.837 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.788684e-01 0.747 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.743101e-01 0.759 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.501083e-01 0.824 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.441128e-01 0.841 0 0
Cellular Senescence R-HSA-2559583 1.520407e-01 0.818 0 0
Signaling by TGFB family members R-HSA-9006936 1.391980e-01 0.856 0 0
Signaling by NTRKs R-HSA-166520 1.787367e-01 0.748 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.788684e-01 0.747 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.622483e-01 0.790 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.341957e-01 0.872 0 0
DNA strand elongation R-HSA-69190 1.607123e-01 0.794 0 0
Post NMDA receptor activation events R-HSA-438064 1.375935e-01 0.861 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.511113e-01 0.821 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 1.788684e-01 0.747 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.382840e-01 0.859 0 0
Inositol phosphate metabolism R-HSA-1483249 1.452247e-01 0.838 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.807355e-01 0.743 0 0
GAB1 signalosome R-HSA-180292 1.807355e-01 0.743 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.807355e-01 0.743 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.807355e-01 0.743 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.808254e-01 0.743 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.826198e-01 0.738 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 2.495754e-01 0.603 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.495754e-01 0.603 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.495754e-01 0.603 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.495754e-01 0.603 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.495754e-01 0.603 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.495754e-01 0.603 0 0
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-5619099 2.495754e-01 0.603 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.495754e-01 0.603 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.180735e-01 0.497 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.180735e-01 0.497 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.180735e-01 0.497 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.180735e-01 0.497 0 0
STAT5 Activation R-HSA-9645135 2.133659e-01 0.671 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.133659e-01 0.671 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.133659e-01 0.671 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.484093e-01 0.605 0 0
Recycling of eIF2:GDP R-HSA-72731 2.484093e-01 0.605 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 3.803228e-01 0.420 0 0
Axonal growth stimulation R-HSA-209563 3.803228e-01 0.420 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.803228e-01 0.420 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.803228e-01 0.420 0 0
MET activates PTPN11 R-HSA-8865999 3.803228e-01 0.420 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.989513e-01 0.701 0 0
Repression of WNT target genes R-HSA-4641265 1.989513e-01 0.701 0 0
Pervasive developmental disorders R-HSA-9005895 1.989513e-01 0.701 0 0
Disorders of Nervous System Development R-HSA-9697154 1.989513e-01 0.701 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.989513e-01 0.701 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.989513e-01 0.701 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.989513e-01 0.701 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.989513e-01 0.701 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.989513e-01 0.701 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.989513e-01 0.701 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.989513e-01 0.701 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.836119e-01 0.547 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.836119e-01 0.547 0 0
MET receptor recycling R-HSA-8875656 2.836119e-01 0.547 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.235490e-01 0.651 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.235490e-01 0.651 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.486962e-01 0.604 0 0
ARMS-mediated activation R-HSA-170984 3.186529e-01 0.497 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.186529e-01 0.497 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.368931e-01 0.360 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 4.368931e-01 0.360 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.368931e-01 0.360 0 0
Nucleotide catabolism defects R-HSA-9735786 4.368931e-01 0.360 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.368931e-01 0.360 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.368931e-01 0.360 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.368931e-01 0.360 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.368931e-01 0.360 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.368931e-01 0.360 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.368931e-01 0.360 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.195939e-01 0.658 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.195939e-01 0.658 0 0
Erythropoietin activates RAS R-HSA-9027284 2.742373e-01 0.562 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.742373e-01 0.562 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.532688e-01 0.452 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.532688e-01 0.452 0 0
2-LTR circle formation R-HSA-164843 3.532688e-01 0.452 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.532688e-01 0.452 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.532688e-01 0.452 0 0
Phosphorylation of the APC/C R-HSA-176412 3.000269e-01 0.523 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.000269e-01 0.523 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.604032e-01 0.584 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.813322e-01 0.551 0 0
Notch-HLH transcription pathway R-HSA-350054 2.813322e-01 0.551 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.813322e-01 0.551 0 0
Signaling by APC mutants R-HSA-4839744 3.872454e-01 0.412 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.872454e-01 0.412 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.872454e-01 0.412 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.872454e-01 0.412 0 0
Activation of AMPA receptors R-HSA-399710 4.883021e-01 0.311 0 0
NrCAM interactions R-HSA-447038 4.883021e-01 0.311 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.883021e-01 0.311 0 0
NTRK2 activates RAC1 R-HSA-9032759 4.883021e-01 0.311 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.883021e-01 0.311 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.883021e-01 0.311 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.883021e-01 0.311 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.641099e-01 0.578 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.025044e-01 0.519 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.025044e-01 0.519 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.484202e-01 0.605 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.518249e-01 0.454 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.518249e-01 0.454 0 0
Deadenylation of mRNA R-HSA-429947 3.238433e-01 0.490 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.204111e-01 0.376 0 0
Activation of RAC1 R-HSA-428540 4.204111e-01 0.376 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.204111e-01 0.376 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.204111e-01 0.376 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.336695e-01 0.631 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.336695e-01 0.631 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.965568e-01 0.528 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.031485e-01 0.395 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.031485e-01 0.395 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.031485e-01 0.395 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.526309e-01 0.344 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.526309e-01 0.344 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.526309e-01 0.344 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.350205e-01 0.272 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.350205e-01 0.272 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.350205e-01 0.272 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.350205e-01 0.272 0 0
MAP2K and MAPK activation R-HSA-5674135 3.295895e-01 0.482 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.152891e-01 0.667 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.152891e-01 0.667 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.283871e-01 0.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.283871e-01 0.368 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.283871e-01 0.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.283871e-01 0.368 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.094679e-01 0.388 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.094679e-01 0.388 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.094679e-01 0.388 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.838012e-01 0.315 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.532341e-01 0.344 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.532341e-01 0.344 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.532341e-01 0.344 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.306274e-01 0.366 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.306274e-01 0.366 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.193670e-01 0.496 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.138451e-01 0.289 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.138451e-01 0.289 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.138451e-01 0.289 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.137376e-01 0.383 0 0
Recycling pathway of L1 R-HSA-437239 4.302154e-01 0.366 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.994487e-01 0.399 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.427085e-01 0.265 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.427085e-01 0.265 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.427085e-01 0.265 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.427085e-01 0.265 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.427085e-01 0.265 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.427085e-01 0.265 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.874405e-01 0.312 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.982785e-01 0.303 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.474617e-01 0.262 0 0
Signaling by ERBB4 R-HSA-1236394 5.258091e-01 0.279 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.485039e-01 0.261 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.998707e-01 0.523 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.702948e-01 0.328 0 0
EGFR downregulation R-HSA-182971 2.821740e-01 0.549 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.490586e-01 0.457 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.045521e-01 0.516 0 0
mRNA Capping R-HSA-72086 4.306274e-01 0.366 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.515779e-01 0.345 0 0
Intra-Golgi traffic R-HSA-6811438 1.936451e-01 0.713 0 0
Ribosome-associated quality control R-HSA-9948299 4.147202e-01 0.382 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.951492e-01 0.710 0 0
Activation of the pre-replicative complex R-HSA-68962 2.641099e-01 0.578 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.447367e-01 0.611 0 0
Generation of second messenger molecules R-HSA-202433 4.676042e-01 0.330 0 0
IGF1R signaling cascade R-HSA-2428924 5.340969e-01 0.272 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 2.028284e-01 0.693 0 0
Polo-like kinase mediated events R-HSA-156711 3.775978e-01 0.423 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.813322e-01 0.551 0 0
Integration of provirus R-HSA-162592 4.204111e-01 0.376 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.515779e-01 0.345 0 0
Nephrin family interactions R-HSA-373753 2.195939e-01 0.658 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.775978e-01 0.423 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.642376e-01 0.578 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.247808e-01 0.280 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.898398e-01 0.310 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.474617e-01 0.262 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.000269e-01 0.523 0 0
COPII-mediated vesicle transport R-HSA-204005 3.329608e-01 0.478 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.484093e-01 0.605 0 0
PI3K/AKT activation R-HSA-198203 3.532688e-01 0.452 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.813322e-01 0.551 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.872454e-01 0.412 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.004656e-01 0.522 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.481784e-01 0.605 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.881512e-01 0.411 1 1
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.715715e-01 0.430 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.324072e-01 0.274 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.186529e-01 0.497 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.368931e-01 0.360 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.742373e-01 0.562 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.259306e-01 0.487 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.883021e-01 0.311 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.350205e-01 0.272 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.127231e-01 0.290 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.784754e-01 0.320 0 0
Homology Directed Repair R-HSA-5693538 2.873330e-01 0.542 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.014863e-01 0.300 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 3.147058e-01 0.502 0 0
L1CAM interactions R-HSA-373760 3.654524e-01 0.437 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.634396e-01 0.334 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.526309e-01 0.344 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.094679e-01 0.388 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.306274e-01 0.366 0 0
G2/M Checkpoints R-HSA-69481 2.087349e-01 0.680 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.000269e-01 0.523 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.770485e-01 0.557 0 0
Signaling by WNT in cancer R-HSA-4791275 3.004656e-01 0.522 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.495754e-01 0.603 0 0
PTK6 Expression R-HSA-8849473 2.484093e-01 0.605 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.532688e-01 0.452 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.028284e-01 0.693 0 0
Synthesis of PI R-HSA-1483226 3.872454e-01 0.412 0 0
Activation of AKT2 R-HSA-165158 4.883021e-01 0.311 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.518249e-01 0.454 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.185167e-01 0.661 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.462836e-01 0.461 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.532341e-01 0.344 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.515779e-01 0.345 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.127231e-01 0.290 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.127231e-01 0.290 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.097338e-01 0.509 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.998788e-01 0.699 0 0
Prolonged ERK activation events R-HSA-169893 3.000269e-01 0.523 0 0
Signaling by MET R-HSA-6806834 3.366236e-01 0.473 0 0
Meiosis R-HSA-1500620 1.867995e-01 0.729 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.951492e-01 0.710 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.813322e-01 0.551 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.186529e-01 0.497 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.368931e-01 0.360 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.368931e-01 0.360 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.259306e-01 0.487 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.872454e-01 0.412 0 0
MET activates RAS signaling R-HSA-8851805 4.526309e-01 0.344 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.881512e-01 0.411 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.838012e-01 0.315 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.138451e-01 0.289 0 0
Nuclear RNA decay R-HSA-9930044 5.127231e-01 0.290 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.406659e-01 0.619 0 0
Cilium Assembly R-HSA-5617833 5.303735e-01 0.275 0 0
Vasopressin-like receptors R-HSA-388479 4.368931e-01 0.360 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.300911e-01 0.638 0 0
Rap1 signalling R-HSA-392517 4.031485e-01 0.395 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.295895e-01 0.482 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.283871e-01 0.368 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.856996e-01 0.314 0 0
Generic Transcription Pathway R-HSA-212436 4.623135e-01 0.335 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.186529e-01 0.497 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.526309e-01 0.344 0 0
DAP12 interactions R-HSA-2172127 3.798591e-01 0.420 0 0
Reproduction R-HSA-1474165 3.273776e-01 0.485 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.385482e-01 0.269 0 0
Signaling by FGFR2 R-HSA-5654738 4.662069e-01 0.331 0 0
Specification of the neural plate border R-HSA-9834899 4.031485e-01 0.395 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.201575e-01 0.377 0 0
Signalling to ERKs R-HSA-187687 3.749288e-01 0.426 0 0
Chromosome Maintenance R-HSA-73886 3.161650e-01 0.500 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.692521e-01 0.329 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.495754e-01 0.603 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.495754e-01 0.603 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.180735e-01 0.497 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.180735e-01 0.497 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.180735e-01 0.497 0 0
MET interacts with TNS proteins R-HSA-8875513 3.803228e-01 0.420 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.836119e-01 0.547 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.368931e-01 0.360 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.259306e-01 0.487 0 0
Bicarbonate transporters R-HSA-425381 3.872454e-01 0.412 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.025044e-01 0.519 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.209922e-01 0.656 0 0
NF-kB is activated and signals survival R-HSA-209560 4.204111e-01 0.376 0 0
Signaling by AXIN mutants R-HSA-4839735 4.204111e-01 0.376 0 0
Signaling by LTK R-HSA-9842663 4.526309e-01 0.344 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.350205e-01 0.272 0 0
Synthesis of PS R-HSA-1483101 5.350205e-01 0.272 0 0
PDE3B signalling R-HSA-165160 5.350205e-01 0.272 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.350205e-01 0.272 0 0
PKB-mediated events R-HSA-109703 5.350205e-01 0.272 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.406659e-01 0.619 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.727110e-01 0.429 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.776204e-01 0.321 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.109894e-01 0.386 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.714183e-01 0.430 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.247808e-01 0.280 0 0
Orc1 removal from chromatin R-HSA-68949 5.122386e-01 0.291 0 0
rRNA processing R-HSA-72312 4.554440e-01 0.342 0 0
Adherens junctions interactions R-HSA-418990 3.469804e-01 0.460 0 0
Autophagy R-HSA-9612973 4.987142e-01 0.302 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.052434e-01 0.392 0 0
Cell-cell junction organization R-HSA-421270 4.428827e-01 0.354 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.344155e-01 0.362 0 0
Parasite infection R-HSA-9664407 4.344155e-01 0.362 0 0
Leishmania phagocytosis R-HSA-9664417 4.344155e-01 0.362 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.593971e-01 0.444 0 0
Aggrephagy R-HSA-9646399 2.965568e-01 0.528 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.995899e-01 0.398 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.452761e-01 0.462 0 0
Frs2-mediated activation R-HSA-170968 4.838012e-01 0.315 0 0
MHC class II antigen presentation R-HSA-2132295 2.455158e-01 0.610 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.593971e-01 0.444 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.122978e-01 0.385 0 0
MAPK family signaling cascades R-HSA-5683057 2.236904e-01 0.650 0 0
GPVI-mediated activation cascade R-HSA-114604 3.936377e-01 0.405 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.821822e-01 0.418 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.821822e-01 0.418 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.186529e-01 0.497 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.532688e-01 0.452 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.119923e-01 0.385 0 0
Macroautophagy R-HSA-1632852 4.442648e-01 0.352 0 0
Ub-specific processing proteases R-HSA-5689880 3.821822e-01 0.418 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.977772e-01 0.704 0 0
Neurexins and neuroligins R-HSA-6794361 3.522234e-01 0.453 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.593971e-01 0.444 0 0
Negative regulation of FLT3 R-HSA-9706369 3.000269e-01 0.523 0 0
Ca2+ pathway R-HSA-4086398 3.727110e-01 0.429 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.368931e-01 0.360 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.883021e-01 0.311 0 0
Degradation of CDH1 R-HSA-9766229 4.634396e-01 0.334 0 0
Heme signaling R-HSA-9707616 5.047453e-01 0.297 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.068143e-01 0.684 0 0
Selective autophagy R-HSA-9663891 2.246990e-01 0.648 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.730966e-01 0.564 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.047453e-01 0.297 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.366236e-01 0.473 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.117923e-01 0.674 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.908736e-01 0.408 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.235490e-01 0.651 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.526309e-01 0.344 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.138451e-01 0.289 1 1
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.411490e-01 0.267 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.238433e-01 0.490 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.122978e-01 0.385 0 0
HDMs demethylate histones R-HSA-3214842 3.452761e-01 0.462 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.325280e-01 0.634 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.495754e-01 0.603 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.495754e-01 0.603 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.186529e-01 0.497 0 0
Sensory perception of sour taste R-HSA-9729555 4.368931e-01 0.360 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.368931e-01 0.360 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.397965e-01 0.620 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.000269e-01 0.523 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.259306e-01 0.487 0 0
Inositol transporters R-HSA-429593 4.883021e-01 0.311 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.518249e-01 0.454 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.802876e-01 0.552 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.375329e-01 0.472 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.350205e-01 0.272 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.350205e-01 0.272 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.818205e-01 0.550 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.366236e-01 0.473 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.926665e-01 0.307 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.438210e-01 0.265 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.906500e-01 0.537 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.702948e-01 0.328 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.776204e-01 0.321 0 0
S Phase R-HSA-69242 3.294770e-01 0.482 0 0
Basigin interactions R-HSA-210991 4.532341e-01 0.344 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.993497e-01 0.399 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.247808e-01 0.280 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.474617e-01 0.262 0 0
Ion homeostasis R-HSA-5578775 4.137376e-01 0.383 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.213428e-01 0.375 0 0
Ion transport by P-type ATPases R-HSA-936837 5.340969e-01 0.272 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.288676e-01 0.640 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.742373e-01 0.562 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.189348e-01 0.496 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.427085e-01 0.265 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.775978e-01 0.423 0 0
Calmodulin induced events R-HSA-111933 3.936377e-01 0.405 0 0
Interferon Signaling R-HSA-913531 2.607630e-01 0.584 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.180735e-01 0.497 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.484093e-01 0.605 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.484093e-01 0.605 0 0
Sodium/Proton exchangers R-HSA-425986 2.836119e-01 0.547 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.368931e-01 0.360 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.532688e-01 0.452 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.350205e-01 0.272 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.838012e-01 0.315 0 0
CaM pathway R-HSA-111997 3.936377e-01 0.405 0 0
DAG and IP3 signaling R-HSA-1489509 3.966761e-01 0.402 0 0
PKR-mediated signaling R-HSA-9833482 4.662069e-01 0.331 0 0
Interleukin-15 signaling R-HSA-8983432 4.526309e-01 0.344 0 0
Maturation of nucleoprotein R-HSA-9683610 4.838012e-01 0.315 0 0
Ca-dependent events R-HSA-111996 5.211978e-01 0.283 0 0
RUNX2 regulates bone development R-HSA-8941326 3.936377e-01 0.405 0 0
Maturation of nucleoprotein R-HSA-9694631 4.031485e-01 0.395 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.031485e-01 0.395 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.180735e-01 0.497 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.484093e-01 0.605 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.484093e-01 0.605 0 0
FasL/ CD95L signaling R-HSA-75157 3.803228e-01 0.420 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.186529e-01 0.497 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.397965e-01 0.620 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.204111e-01 0.376 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.350205e-01 0.272 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.838012e-01 0.315 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.427085e-01 0.265 0 0
Growth hormone receptor signaling R-HSA-982772 3.025044e-01 0.519 0 0
Glucose metabolism R-HSA-70326 2.779125e-01 0.556 0 0
Miscellaneous transport and binding events R-HSA-5223345 3.375329e-01 0.472 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.350205e-01 0.272 0 0
TRAIL signaling R-HSA-75158 5.350205e-01 0.272 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.285409e-01 0.483 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.776204e-01 0.321 0 0
Potential therapeutics for SARS R-HSA-9679191 3.474079e-01 0.459 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.122386e-01 0.291 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.035733e-01 0.298 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.794260e-01 0.319 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.097591e-01 0.387 0 0
Signaling by Leptin R-HSA-2586552 3.532688e-01 0.452 0 0
SARS-CoV Infections R-HSA-9679506 3.649766e-01 0.438 0 0
Interleukin-37 signaling R-HSA-9008059 4.515779e-01 0.345 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.883021e-01 0.311 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.485116e-01 0.261 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.516885e-01 0.258 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.516885e-01 0.258 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.516885e-01 0.258 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.516885e-01 0.258 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.603004e-01 0.252 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.694941e-01 0.245 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.694941e-01 0.245 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.694941e-01 0.245 0 0
Interleukin-7 signaling R-HSA-1266695 5.694941e-01 0.245 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.703566e-01 0.244 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.703566e-01 0.244 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.703566e-01 0.244 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.705406e-01 0.244 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.723385e-01 0.242 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.750434e-01 0.240 0 0
G-protein mediated events R-HSA-112040 5.767480e-01 0.239 0 0
Signaling by LTK in cancer R-HSA-9842640 5.774759e-01 0.238 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.774759e-01 0.238 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.774759e-01 0.238 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.774759e-01 0.238 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.774759e-01 0.238 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.774759e-01 0.238 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.774759e-01 0.238 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.774759e-01 0.238 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.774759e-01 0.238 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.774759e-01 0.238 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.774759e-01 0.238 0 0
NADPH regeneration R-HSA-389542 5.774759e-01 0.238 0 0
Leukotriene receptors R-HSA-391906 5.774759e-01 0.238 0 0
Neurofascin interactions R-HSA-447043 5.774759e-01 0.238 0 0
Peptide chain elongation R-HSA-156902 5.814435e-01 0.235 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.861069e-01 0.232 0 0
Synthesis of DNA R-HSA-69239 5.861069e-01 0.232 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.887400e-01 0.230 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.889409e-01 0.230 0 0
Regulation of CDH1 Function R-HSA-9764561 5.894022e-01 0.230 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.894022e-01 0.230 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.908506e-01 0.229 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.908506e-01 0.229 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.908506e-01 0.229 0 0
Metalloprotease DUBs R-HSA-5689901 5.908506e-01 0.229 0 0
Phase 2 - plateau phase R-HSA-5576893 5.967707e-01 0.224 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.967707e-01 0.224 0 0
Synthesis of PG R-HSA-1483148 5.967707e-01 0.224 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.967707e-01 0.224 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.025086e-01 0.220 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.047907e-01 0.218 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.115101e-01 0.214 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.115101e-01 0.214 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.115101e-01 0.214 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.115101e-01 0.214 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.115101e-01 0.214 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.160572e-01 0.210 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.160572e-01 0.210 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.160572e-01 0.210 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.160572e-01 0.210 0 0
Disinhibition of SNARE formation R-HSA-114516 6.160572e-01 0.210 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.160572e-01 0.210 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.160572e-01 0.210 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.160572e-01 0.210 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.160572e-01 0.210 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.160572e-01 0.210 0 0
VLDL clearance R-HSA-8964046 6.160572e-01 0.210 0 0
Netrin mediated repulsion signals R-HSA-418886 6.160572e-01 0.210 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.160572e-01 0.210 0 0
Regulation of PTEN localization R-HSA-8948747 6.160572e-01 0.210 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.160572e-01 0.210 0 0
TCR signaling R-HSA-202403 6.185019e-01 0.209 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.219455e-01 0.206 0 0
MET promotes cell motility R-HSA-8875878 6.243130e-01 0.205 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.243130e-01 0.205 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.243130e-01 0.205 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.288967e-01 0.201 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.300798e-01 0.201 0 0
Muscle contraction R-HSA-397014 6.305120e-01 0.200 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.315551e-01 0.200 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.324911e-01 0.199 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.324911e-01 0.199 0 0
tRNA processing R-HSA-72306 6.336499e-01 0.198 0 0
Gap junction trafficking and regulation R-HSA-157858 6.357865e-01 0.197 0 0
DNA Damage Bypass R-HSA-73893 6.357865e-01 0.197 0 0
Adaptive Immune System R-HSA-1280218 6.393209e-01 0.194 1 0
Regulation of endogenous retroelements R-HSA-9842860 6.396501e-01 0.194 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.403013e-01 0.194 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.412565e-01 0.193 0 0
Signaling by ALK R-HSA-201556 6.412565e-01 0.193 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.458872e-01 0.190 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.458872e-01 0.190 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.458872e-01 0.190 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.458872e-01 0.190 0 0
Platelet sensitization by LDL R-HSA-432142 6.458872e-01 0.190 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 6.458872e-01 0.190 0 0
PLC beta mediated events R-HSA-112043 6.462489e-01 0.190 0 0
MAP kinase activation R-HSA-450294 6.462489e-01 0.190 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.491498e-01 0.188 0 0
Signaling by Erythropoietin R-HSA-9006335 6.506822e-01 0.187 0 0
Late endosomal microautophagy R-HSA-9615710 6.506822e-01 0.187 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.506822e-01 0.187 0 0
PI3K Cascade R-HSA-109704 6.507101e-01 0.187 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.511177e-01 0.186 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.511177e-01 0.186 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.511177e-01 0.186 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.511177e-01 0.186 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.511177e-01 0.186 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.511177e-01 0.186 0 0
Adrenoceptors R-HSA-390696 6.511177e-01 0.186 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.511177e-01 0.186 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.511177e-01 0.186 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.511177e-01 0.186 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.515100e-01 0.186 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.559040e-01 0.183 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.576911e-01 0.182 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.576911e-01 0.182 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.576911e-01 0.182 0 0
Diseases of Immune System R-HSA-5260271 6.576911e-01 0.182 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.576911e-01 0.182 0 0
Interleukin-2 family signaling R-HSA-451927 6.576911e-01 0.182 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.588440e-01 0.181 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.596356e-01 0.181 0 0
HCMV Early Events R-HSA-9609690 6.669721e-01 0.176 0 0
Signaling by FGFR in disease R-HSA-1226099 6.681953e-01 0.175 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.686110e-01 0.175 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.686110e-01 0.175 0 0
Translesion Synthesis by POLH R-HSA-110320 6.686110e-01 0.175 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.686110e-01 0.175 0 0
Activation of BH3-only proteins R-HSA-114452 6.691799e-01 0.174 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.792387e-01 0.168 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.793690e-01 0.168 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.802123e-01 0.167 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.829785e-01 0.166 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.829785e-01 0.166 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.829785e-01 0.166 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.829785e-01 0.166 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.829785e-01 0.166 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.829785e-01 0.166 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.829785e-01 0.166 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.829785e-01 0.166 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.829785e-01 0.166 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.829785e-01 0.166 0 0
PPARA activates gene expression R-HSA-1989781 6.834426e-01 0.165 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.837122e-01 0.165 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.839139e-01 0.165 0 0
Eukaryotic Translation Termination R-HSA-72764 6.839139e-01 0.165 0 0
Insulin receptor signalling cascade R-HSA-74751 6.855997e-01 0.164 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.869496e-01 0.163 0 0
Cargo concentration in the ER R-HSA-5694530 6.869496e-01 0.163 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.890084e-01 0.162 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.901396e-01 0.161 0 0
Signal transduction by L1 R-HSA-445144 6.901396e-01 0.161 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.901396e-01 0.161 0 0
Signaling by NODAL R-HSA-1181150 6.901396e-01 0.161 0 0
Protein hydroxylation R-HSA-9629569 6.901396e-01 0.161 0 0
Formation of definitive endoderm R-HSA-9823730 6.901396e-01 0.161 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.901396e-01 0.161 0 0
SLC transporter disorders R-HSA-5619102 6.907972e-01 0.161 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.919506e-01 0.160 0 0
Signaling by NOTCH1 R-HSA-1980143 6.919506e-01 0.160 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.930935e-01 0.159 0 0
Signaling by WNT R-HSA-195721 6.969260e-01 0.157 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.982623e-01 0.156 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.997337e-01 0.155 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.038846e-01 0.152 0 0
Mitochondrial biogenesis R-HSA-1592230 7.073623e-01 0.150 0 0
Cellular response to starvation R-HSA-9711097 7.076900e-01 0.150 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.101819e-01 0.149 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.105018e-01 0.148 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.105018e-01 0.148 0 0
Signalling to RAS R-HSA-167044 7.105018e-01 0.148 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.105018e-01 0.148 0 0
ERK/MAPK targets R-HSA-198753 7.105018e-01 0.148 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.105018e-01 0.148 0 0
Lagging Strand Synthesis R-HSA-69186 7.105018e-01 0.148 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.119313e-01 0.148 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.119313e-01 0.148 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.119313e-01 0.148 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.119313e-01 0.148 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.119313e-01 0.148 0 0
Pexophagy R-HSA-9664873 7.119313e-01 0.148 0 0
Formation of apoptosome R-HSA-111458 7.119313e-01 0.148 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.119313e-01 0.148 0 0
Interleukin-27 signaling R-HSA-9020956 7.119313e-01 0.148 0 0
Maturation of spike protein R-HSA-9683686 7.119313e-01 0.148 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.144056e-01 0.146 0 0
Signaling by FGFR R-HSA-190236 7.144056e-01 0.146 0 0
RNA Polymerase I Transcription R-HSA-73864 7.145780e-01 0.146 0 0
Signaling by FGFR4 R-HSA-5654743 7.182386e-01 0.144 0 0
Signaling by NOTCH3 R-HSA-9012852 7.193173e-01 0.143 0 0
G alpha (z) signalling events R-HSA-418597 7.193173e-01 0.143 0 0
G-protein beta:gamma signalling R-HSA-397795 7.203197e-01 0.142 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.203197e-01 0.142 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.297311e-01 0.137 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.297311e-01 0.137 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.318146e-01 0.136 0 0
RMTs methylate histone arginines R-HSA-3214858 7.320723e-01 0.135 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.343716e-01 0.134 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.359355e-01 0.133 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.359355e-01 0.133 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.382415e-01 0.132 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.382415e-01 0.132 0 0
vRNA Synthesis R-HSA-192814 7.382415e-01 0.132 0 0
vRNP Assembly R-HSA-192905 7.382415e-01 0.132 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.382415e-01 0.132 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.382415e-01 0.132 0 0
Suppression of apoptosis R-HSA-9635465 7.382415e-01 0.132 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.382415e-01 0.132 0 0
Prostanoid ligand receptors R-HSA-391908 7.382415e-01 0.132 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.393087e-01 0.131 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.429180e-01 0.129 0 0
Selenocysteine synthesis R-HSA-2408557 7.429180e-01 0.129 0 0
IRS-mediated signalling R-HSA-112399 7.439031e-01 0.128 0 0
Signaling by FGFR3 R-HSA-5654741 7.453895e-01 0.128 0 0
Adipogenesis R-HSA-9843745 7.467726e-01 0.127 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.478644e-01 0.126 0 0
LDL clearance R-HSA-8964038 7.478644e-01 0.126 0 0
Dual Incision in GG-NER R-HSA-5696400 7.508532e-01 0.124 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.508532e-01 0.124 0 0
Signal amplification R-HSA-392518 7.508532e-01 0.124 0 0
Hyaluronan metabolism R-HSA-2142845 7.508532e-01 0.124 0 0
Mitophagy R-HSA-5205647 7.508532e-01 0.124 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.508532e-01 0.124 0 0
Circadian clock R-HSA-9909396 7.546648e-01 0.122 0 0
Interleukin-17 signaling R-HSA-448424 7.553003e-01 0.122 1 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.581952e-01 0.120 0 0
Diseases of DNA repair R-HSA-9675135 7.581952e-01 0.120 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.581952e-01 0.120 0 0
Protein folding R-HSA-391251 7.583260e-01 0.120 0 0
Viral mRNA Translation R-HSA-192823 7.608106e-01 0.119 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.621502e-01 0.118 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.621502e-01 0.118 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.621502e-01 0.118 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.621502e-01 0.118 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.621502e-01 0.118 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.621502e-01 0.118 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.621502e-01 0.118 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.621502e-01 0.118 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.621502e-01 0.118 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.621502e-01 0.118 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.621502e-01 0.118 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.621502e-01 0.118 0 0
Carnitine shuttle R-HSA-200425 7.649416e-01 0.116 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.649416e-01 0.116 0 0
Syndecan interactions R-HSA-3000170 7.649416e-01 0.116 0 0
Regulation of Apoptosis R-HSA-169911 7.650865e-01 0.116 0 0
PERK regulates gene expression R-HSA-381042 7.650865e-01 0.116 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.650865e-01 0.116 0 0
Peroxisomal protein import R-HSA-9033241 7.668629e-01 0.115 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.668629e-01 0.115 0 0
Extension of Telomeres R-HSA-180786 7.668629e-01 0.115 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.674571e-01 0.115 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.704964e-01 0.113 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.749060e-01 0.111 1 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.777413e-01 0.109 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.777413e-01 0.109 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.777413e-01 0.109 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.777413e-01 0.109 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.777413e-01 0.109 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.777413e-01 0.109 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.810041e-01 0.107 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.810041e-01 0.107 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.810041e-01 0.107 0 0
HCMV Late Events R-HSA-9610379 7.833895e-01 0.106 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.838763e-01 0.106 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.838763e-01 0.106 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.838763e-01 0.106 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.838763e-01 0.106 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.838763e-01 0.106 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.838763e-01 0.106 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.838763e-01 0.106 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.838763e-01 0.106 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.838763e-01 0.106 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.838763e-01 0.106 0 0
Regulation of IFNG signaling R-HSA-877312 7.838763e-01 0.106 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.838763e-01 0.106 0 0
Interleukin-35 Signalling R-HSA-8984722 7.838763e-01 0.106 0 0
OAS antiviral response R-HSA-8983711 7.838763e-01 0.106 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.859746e-01 0.105 1 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.960950e-01 0.099 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.960950e-01 0.099 0 0
Tight junction interactions R-HSA-420029 7.960950e-01 0.099 0 0
Hyaluronan degradation R-HSA-2160916 7.960950e-01 0.099 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.960950e-01 0.099 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.983196e-01 0.098 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.014878e-01 0.096 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.036191e-01 0.095 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.036191e-01 0.095 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.036191e-01 0.095 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.036191e-01 0.095 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.036191e-01 0.095 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.036191e-01 0.095 0 0
Formation of axial mesoderm R-HSA-9796292 8.036191e-01 0.095 0 0
Interleukin-6 signaling R-HSA-1059683 8.036191e-01 0.095 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.044558e-01 0.094 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.080314e-01 0.093 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.091501e-01 0.092 1 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.102575e-01 0.091 0 0
MET activates PTK2 signaling R-HSA-8874081 8.102575e-01 0.091 0 0
UCH proteinases R-HSA-5689603 8.129825e-01 0.090 0 0
The phototransduction cascade R-HSA-2514856 8.148272e-01 0.089 0 0
Stabilization of p53 R-HSA-69541 8.155073e-01 0.089 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.164409e-01 0.088 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.164409e-01 0.088 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.165416e-01 0.088 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.165416e-01 0.088 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.170327e-01 0.088 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.170327e-01 0.088 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.170327e-01 0.088 1 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.194455e-01 0.086 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.215594e-01 0.085 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.215594e-01 0.085 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.215594e-01 0.085 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.215594e-01 0.085 0 0
Removal of the Flap Intermediate R-HSA-69166 8.215594e-01 0.085 0 0
cGMP effects R-HSA-418457 8.215594e-01 0.085 0 0
Physiological factors R-HSA-5578768 8.215594e-01 0.085 0 0
Malate-aspartate shuttle R-HSA-9856872 8.215594e-01 0.085 0 0
Zinc transporters R-HSA-435354 8.215594e-01 0.085 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.235180e-01 0.084 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.235180e-01 0.084 1 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.247428e-01 0.084 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.247428e-01 0.084 0 0
ER-Phagosome pathway R-HSA-1236974 8.263596e-01 0.083 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.265777e-01 0.083 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.265777e-01 0.083 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.282061e-01 0.082 0 0
PCP/CE pathway R-HSA-4086400 8.296523e-01 0.081 0 0
Base Excision Repair R-HSA-73884 8.338762e-01 0.079 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.342144e-01 0.079 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.342144e-01 0.079 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.342144e-01 0.079 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.359719e-01 0.078 0 0
Telomere Extension By Telomerase R-HSA-171319 8.359719e-01 0.078 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.362765e-01 0.078 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.362765e-01 0.078 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.369592e-01 0.077 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.375304e-01 0.077 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.378618e-01 0.077 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.378618e-01 0.077 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.378618e-01 0.077 0 0
p38MAPK events R-HSA-171007 8.378618e-01 0.077 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.378618e-01 0.077 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.378618e-01 0.077 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.378618e-01 0.077 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.378618e-01 0.077 0 0
Protein methylation R-HSA-8876725 8.378618e-01 0.077 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.378618e-01 0.077 0 0
Interleukin-1 signaling R-HSA-9020702 8.385721e-01 0.076 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.431077e-01 0.074 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.431973e-01 0.074 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.432546e-01 0.074 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.434936e-01 0.074 1 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.470178e-01 0.072 0 0
HIV Transcription Initiation R-HSA-167161 8.470178e-01 0.072 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.470178e-01 0.072 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.470178e-01 0.072 0 0
Translation of Structural Proteins R-HSA-9683701 8.470178e-01 0.072 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.476101e-01 0.072 0 0
Viral Infection Pathways R-HSA-9824446 8.477151e-01 0.072 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.511090e-01 0.070 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.518761e-01 0.070 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.518761e-01 0.070 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.526756e-01 0.069 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.526756e-01 0.069 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.526756e-01 0.069 0 0
Attachment and Entry R-HSA-9678110 8.526756e-01 0.069 0 0
Virus Assembly and Release R-HSA-168268 8.526756e-01 0.069 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.548462e-01 0.068 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.557936e-01 0.068 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.584918e-01 0.066 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.600919e-01 0.065 0 0
Signaling by FGFR1 R-HSA-5654736 8.600919e-01 0.065 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.600919e-01 0.065 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.616482e-01 0.065 1 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.653302e-01 0.063 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.661368e-01 0.062 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.661368e-01 0.062 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.661368e-01 0.062 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.661368e-01 0.062 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.661368e-01 0.062 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.685303e-01 0.061 1 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.686582e-01 0.061 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.686582e-01 0.061 0 0
Downstream signal transduction R-HSA-186763 8.686582e-01 0.061 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.686582e-01 0.061 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.728736e-01 0.059 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.728736e-01 0.059 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.736820e-01 0.059 0 0
Gap junction trafficking R-HSA-190828 8.737413e-01 0.059 0 0
G1 Phase R-HSA-69236 8.737413e-01 0.059 0 0
Cyclin D associated events in G1 R-HSA-69231 8.737413e-01 0.059 0 0
Dual incision in TC-NER R-HSA-6782135 8.753594e-01 0.058 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.783688e-01 0.056 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.783688e-01 0.056 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.783688e-01 0.056 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.783688e-01 0.056 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.783688e-01 0.056 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.783688e-01 0.056 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.816835e-01 0.055 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.816835e-01 0.055 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.824378e-01 0.054 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.862851e-01 0.052 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.870029e-01 0.052 0 0
Cardiogenesis R-HSA-9733709 8.870029e-01 0.052 0 0
Interleukin-1 family signaling R-HSA-446652 8.870396e-01 0.052 1 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.881105e-01 0.052 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.894837e-01 0.051 0 0
PKA activation in glucagon signalling R-HSA-164378 8.894837e-01 0.051 0 0
PKA activation R-HSA-163615 8.894837e-01 0.051 0 0
Tie2 Signaling R-HSA-210993 8.894837e-01 0.051 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.894837e-01 0.051 0 0
Apoptotic factor-mediated response R-HSA-111471 8.894837e-01 0.051 0 0
Mismatch Repair R-HSA-5358508 8.894837e-01 0.051 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.894837e-01 0.051 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.894837e-01 0.051 0 0
Protein localization R-HSA-9609507 8.913208e-01 0.050 0 0
DNA Replication R-HSA-69306 8.913208e-01 0.050 0 0
Cardiac conduction R-HSA-5576891 8.948237e-01 0.048 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.955507e-01 0.048 0 0
Synthesis of PC R-HSA-1483191 8.962438e-01 0.048 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.995834e-01 0.046 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.995834e-01 0.046 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.995834e-01 0.046 0 0
The NLRP3 inflammasome R-HSA-844456 8.995834e-01 0.046 0 0
Other interleukin signaling R-HSA-449836 8.995834e-01 0.046 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.995834e-01 0.046 0 0
Methionine salvage pathway R-HSA-1237112 8.995834e-01 0.046 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.995834e-01 0.046 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.995834e-01 0.046 0 0
HCMV Infection R-HSA-9609646 8.997861e-01 0.046 0 0
Diseases of programmed cell death R-HSA-9645723 9.011119e-01 0.045 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.016117e-01 0.045 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.016117e-01 0.045 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.016117e-01 0.045 0 0
Intraflagellar transport R-HSA-5620924 9.029021e-01 0.044 0 0
GPER1 signaling R-HSA-9634597 9.029021e-01 0.044 0 0
Metal ion SLC transporters R-HSA-425410 9.029021e-01 0.044 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.029467e-01 0.044 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.029467e-01 0.044 0 0
eNOS activation R-HSA-203615 9.029467e-01 0.044 0 0
Signaling by NOTCH2 R-HSA-1980145 9.029467e-01 0.044 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.029467e-01 0.044 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.033477e-01 0.044 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.061392e-01 0.043 0 0
Translation of Structural Proteins R-HSA-9694635 9.083816e-01 0.042 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.087608e-01 0.042 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.087608e-01 0.042 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.091718e-01 0.041 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.091718e-01 0.041 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.091718e-01 0.041 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.096808e-01 0.041 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.128079e-01 0.040 0 0
Integrin cell surface interactions R-HSA-216083 9.133707e-01 0.039 0 0
Glycosphingolipid transport R-HSA-9845576 9.167688e-01 0.038 0 0
G-protein activation R-HSA-202040 9.170999e-01 0.038 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.170999e-01 0.038 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.170999e-01 0.038 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.170999e-01 0.038 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.170999e-01 0.038 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.179685e-01 0.037 0 0
Sensory processing of sound R-HSA-9659379 9.181194e-01 0.037 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.193418e-01 0.037 0 0
Opioid Signalling R-HSA-111885 9.223280e-01 0.035 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.229647e-01 0.035 0 0
Signaling by Insulin receptor R-HSA-74752 9.239582e-01 0.034 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.246772e-01 0.034 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.246772e-01 0.034 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.246772e-01 0.034 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.246772e-01 0.034 0 0
Attachment and Entry R-HSA-9694614 9.246772e-01 0.034 0 0
Ribavirin ADME R-HSA-9755088 9.246772e-01 0.034 0 0
Platelet degranulation R-HSA-114608 9.251717e-01 0.034 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.258365e-01 0.033 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.261553e-01 0.033 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.261553e-01 0.033 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.282843e-01 0.032 1 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.287239e-01 0.032 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.287239e-01 0.032 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.287239e-01 0.032 0 0
Smooth Muscle Contraction R-HSA-445355 9.307359e-01 0.031 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.315624e-01 0.031 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.315624e-01 0.031 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.315624e-01 0.031 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.315624e-01 0.031 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.315624e-01 0.031 0 0
Ethanol oxidation R-HSA-71384 9.315624e-01 0.031 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.315624e-01 0.031 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.315624e-01 0.031 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.340744e-01 0.030 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.340744e-01 0.030 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.340744e-01 0.030 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.340744e-01 0.030 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.348907e-01 0.029 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.363511e-01 0.029 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.378186e-01 0.028 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.378186e-01 0.028 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.378186e-01 0.028 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.378186e-01 0.028 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.398818e-01 0.027 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.435032e-01 0.025 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.435032e-01 0.025 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.435032e-01 0.025 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.435032e-01 0.025 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.435032e-01 0.025 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.435032e-01 0.025 0 0
Interleukin-6 family signaling R-HSA-6783589 9.435032e-01 0.025 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.435666e-01 0.025 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.435666e-01 0.025 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.436540e-01 0.025 0 0
Maturation of spike protein R-HSA-9694548 9.436540e-01 0.025 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.436540e-01 0.025 0 0
Telomere Maintenance R-HSA-157579 9.451511e-01 0.024 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.479321e-01 0.023 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.479321e-01 0.023 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.479321e-01 0.023 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.479321e-01 0.023 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.486684e-01 0.023 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.486684e-01 0.023 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.486684e-01 0.023 0 0
Formation of the nephric duct R-HSA-9830364 9.486684e-01 0.023 0 0
Laminin interactions R-HSA-3000157 9.486684e-01 0.023 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.486684e-01 0.023 0 0
Interferon gamma signaling R-HSA-877300 9.503373e-01 0.022 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.505621e-01 0.022 0 0
Interleukin-12 family signaling R-HSA-447115 9.514923e-01 0.022 0 0
Activation of GABAB receptors R-HSA-991365 9.518992e-01 0.021 0 0
GABA B receptor activation R-HSA-977444 9.518992e-01 0.021 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.518992e-01 0.021 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.518992e-01 0.021 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.523351e-01 0.021 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.533617e-01 0.021 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.533617e-01 0.021 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.533617e-01 0.021 0 0
TRP channels R-HSA-3295583 9.533617e-01 0.021 0 0
Urea cycle R-HSA-70635 9.533617e-01 0.021 0 0
Sphingolipid catabolism R-HSA-9845614 9.533617e-01 0.021 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.533617e-01 0.021 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.533617e-01 0.021 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.543808e-01 0.020 0 0
Regulation of beta-cell development R-HSA-186712 9.543808e-01 0.020 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.555765e-01 0.020 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.555765e-01 0.020 0 0
Co-inhibition by PD-1 R-HSA-389948 9.568693e-01 0.019 0 0
tRNA Aminoacylation R-HSA-379724 9.574978e-01 0.019 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.576261e-01 0.019 0 0
Cristae formation R-HSA-8949613 9.576261e-01 0.019 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.576261e-01 0.019 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.576261e-01 0.019 0 0
Signaling by BMP R-HSA-201451 9.576261e-01 0.019 0 0
Triglyceride biosynthesis R-HSA-75109 9.576261e-01 0.019 0 0
Synthesis of PE R-HSA-1483213 9.576261e-01 0.019 0 0
Insulin processing R-HSA-264876 9.576261e-01 0.019 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.578272e-01 0.019 0 0
Neutrophil degranulation R-HSA-6798695 9.588802e-01 0.018 0 0
Amine ligand-binding receptors R-HSA-375280 9.589837e-01 0.018 0 0
Surfactant metabolism R-HSA-5683826 9.589837e-01 0.018 0 0
Interleukin-12 signaling R-HSA-9020591 9.590759e-01 0.018 0 0
Downstream TCR signaling R-HSA-202424 9.595042e-01 0.018 0 0
Ion channel transport R-HSA-983712 9.602125e-01 0.018 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.604142e-01 0.018 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.615009e-01 0.017 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.615009e-01 0.017 0 0
Inflammasomes R-HSA-622312 9.615009e-01 0.017 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.615009e-01 0.017 0 0
Pyroptosis R-HSA-5620971 9.615009e-01 0.017 0 0
Signaling by NOTCH R-HSA-157118 9.615293e-01 0.017 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.621396e-01 0.017 0 0
Somitogenesis R-HSA-9824272 9.621396e-01 0.017 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.621396e-01 0.017 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.621396e-01 0.017 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.621396e-01 0.017 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.621396e-01 0.017 0 0
Signaling by PDGF R-HSA-186797 9.631419e-01 0.016 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.650215e-01 0.015 0 0
DNA methylation R-HSA-5334118 9.650215e-01 0.015 0 0
Platelet calcium homeostasis R-HSA-418360 9.650215e-01 0.015 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.650215e-01 0.015 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.650215e-01 0.015 0 0
Cellular response to chemical stress R-HSA-9711123 9.654608e-01 0.015 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.656919e-01 0.015 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.662863e-01 0.015 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.677659e-01 0.014 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.682203e-01 0.014 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.682203e-01 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.682203e-01 0.014 0 0
Neurotransmitter clearance R-HSA-112311 9.682203e-01 0.014 0 0
Collagen formation R-HSA-1474290 9.702082e-01 0.013 0 0
Gluconeogenesis R-HSA-70263 9.702681e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.702737e-01 0.013 0 0
Amyloid fiber formation R-HSA-977225 9.705564e-01 0.013 0 0
Budding and maturation of HIV virion R-HSA-162588 9.711268e-01 0.013 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.711268e-01 0.013 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.711268e-01 0.013 0 0
Transmission across Chemical Synapses R-HSA-112315 9.712676e-01 0.013 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.722876e-01 0.012 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.723792e-01 0.012 0 0
Stimuli-sensing channels R-HSA-2672351 9.724072e-01 0.012 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.737677e-01 0.012 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.737677e-01 0.012 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.743192e-01 0.011 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.747222e-01 0.011 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.753048e-01 0.011 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.759187e-01 0.011 0 0
Regulated Necrosis R-HSA-5218859 9.761294e-01 0.010 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.761671e-01 0.010 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.761671e-01 0.010 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.767002e-01 0.010 0 0
Meiotic recombination R-HSA-912446 9.767002e-01 0.010 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.767002e-01 0.010 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.782515e-01 0.010 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.783472e-01 0.010 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.783472e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.783472e-01 0.010 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.783472e-01 0.010 0 0
Translation R-HSA-72766 9.783658e-01 0.009 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.785280e-01 0.009 0 0
Parasitic Infection Pathways R-HSA-9824443 9.793391e-01 0.009 0 0
Leishmania infection R-HSA-9658195 9.793391e-01 0.009 0 0
Selenoamino acid metabolism R-HSA-2408522 9.795165e-01 0.009 0 0
G1/S Transition R-HSA-69206 9.799219e-01 0.009 0 0
Neuronal System R-HSA-112316 9.799411e-01 0.009 0 0
Toll-like Receptor Cascades R-HSA-168898 9.802073e-01 0.009 1 0
Gap junction assembly R-HSA-190861 9.803280e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.803280e-01 0.009 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.803280e-01 0.009 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.803280e-01 0.009 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.803280e-01 0.009 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.803280e-01 0.009 0 0
Hedgehog 'on' state R-HSA-5632684 9.808593e-01 0.008 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.817759e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.821277e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.821277e-01 0.008 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.821277e-01 0.008 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.821277e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.821277e-01 0.008 0 0
Neddylation R-HSA-8951664 9.836917e-01 0.007 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.837628e-01 0.007 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.837628e-01 0.007 0 0
HS-GAG biosynthesis R-HSA-2022928 9.837628e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.837628e-01 0.007 0 0
Triglyceride catabolism R-HSA-163560 9.837628e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.837628e-01 0.007 0 0
Signaling by NOTCH4 R-HSA-9013694 9.846860e-01 0.007 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.852484e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.852484e-01 0.006 0 0
Cleavage of the damaged purine R-HSA-110331 9.852484e-01 0.006 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.852484e-01 0.006 0 0
Degradation of DVL R-HSA-4641258 9.852484e-01 0.006 0 0
Degradation of AXIN R-HSA-4641257 9.852484e-01 0.006 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.852484e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.852484e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.852484e-01 0.006 0 0
Dectin-2 family R-HSA-5621480 9.857711e-01 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.857899e-01 0.006 0 0
G alpha (q) signalling events R-HSA-416476 9.858711e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.861336e-01 0.006 0 0
Depurination R-HSA-73927 9.865982e-01 0.006 0 0
Purine salvage R-HSA-74217 9.865982e-01 0.006 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.869026e-01 0.006 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.878246e-01 0.005 0 0
RAS processing R-HSA-9648002 9.878246e-01 0.005 0 0
Sialic acid metabolism R-HSA-4085001 9.879462e-01 0.005 0 0
Triglyceride metabolism R-HSA-8979227 9.879462e-01 0.005 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.886621e-01 0.005 0 0
FCGR activation R-HSA-2029481 9.887066e-01 0.005 0 0
Developmental Biology R-HSA-1266738 9.888446e-01 0.005 0 0
GABA receptor activation R-HSA-977443 9.889086e-01 0.005 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.889284e-01 0.005 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.889388e-01 0.005 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.889388e-01 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.889388e-01 0.005 0 0
Glycogen metabolism R-HSA-8982491 9.889388e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.897959e-01 0.004 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.899511e-01 0.004 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.899511e-01 0.004 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.899511e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.899511e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.899511e-01 0.004 0 0
Gastrulation R-HSA-9758941 9.901680e-01 0.004 0 0
Signaling by Interleukins R-HSA-449147 9.904095e-01 0.004 1 0
Mitochondrial protein import R-HSA-1268020 9.906137e-01 0.004 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.906137e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.908350e-01 0.004 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.908708e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.908708e-01 0.004 0 0
Heme biosynthesis R-HSA-189451 9.908708e-01 0.004 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.914852e-01 0.004 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.916344e-01 0.004 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.917064e-01 0.004 0 0
Depyrimidination R-HSA-73928 9.917064e-01 0.004 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.919288e-01 0.004 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.919288e-01 0.004 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.919288e-01 0.004 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.920618e-01 0.003 0 0
Cellular response to hypoxia R-HSA-1234174 9.927014e-01 0.003 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.928228e-01 0.003 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.928459e-01 0.003 0 0
FOXO-mediated transcription R-HSA-9614085 9.931260e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.931260e-01 0.003 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.931552e-01 0.003 0 0
Proteasome assembly R-HSA-9907900 9.931552e-01 0.003 0 0
Hedgehog 'off' state R-HSA-5610787 9.936020e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.936020e-01 0.003 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.937818e-01 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.938471e-01 0.003 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.938896e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.941742e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.941742e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.943325e-01 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.943511e-01 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.943511e-01 0.002 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.943511e-01 0.002 0 0
PI Metabolism R-HSA-1483255 9.944607e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.946358e-01 0.002 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.947922e-01 0.002 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.952152e-01 0.002 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.952152e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.953381e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.956045e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.958263e-01 0.002 0 0
Developmental Cell Lineages R-HSA-9734767 9.958491e-01 0.002 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.959627e-01 0.002 0 0
Purine catabolism R-HSA-74259 9.959627e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.959627e-01 0.002 0 0
Platelet homeostasis R-HSA-418346 9.961494e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.961528e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.961528e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.962861e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.965051e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.965051e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.965051e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.967001e-01 0.001 0 0
Hemostasis R-HSA-109582 9.970683e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.971160e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.971307e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.974613e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.975818e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.975818e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.975818e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.976201e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.977332e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.978381e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.980362e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.981030e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.983795e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.984274e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.985280e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.985280e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.985280e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.986629e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.986629e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.988874e-01 0.000 0 0
Integration of energy metabolism R-HSA-163685 9.989208e-01 0.000 0 0
Signaling by Hedgehog R-HSA-5358351 9.990662e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.992489e-01 0.000 0 0
Kidney development R-HSA-9830369 9.992489e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992489e-01 0.000 0 0
Immune System R-HSA-168256 9.993561e-01 0.000 1 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.994371e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.994371e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.994887e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.994887e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.994887e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994887e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.994921e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.996095e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.996095e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.996207e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996441e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.996520e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.996520e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.996617e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996724e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.996809e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997330e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997632e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997688e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997688e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997891e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998444e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998865e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998903e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.998914e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998951e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999050e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999104e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999223e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999337e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999443e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999604e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999674e-01 0.000 0 0
Disease R-HSA-1643685 9.999715e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999814e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999821e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999880e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999889e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999891e-01 0.000 1 0
Metabolism of steroids R-HSA-8957322 9.999922e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999932e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999942e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999946e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999976e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999977e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999981e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999982e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999984e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999991e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999993e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999994e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999996e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 4.440892e-16 15.353 0 0
Metabolism of RNA R-HSA-8953854 9.992007e-16 15.000 0 0
Cellular responses to stress R-HSA-2262752 3.108624e-15 14.507 0 0
Cellular response to heat stress R-HSA-3371556 1.050271e-13 12.979 0 0
Mitotic Anaphase R-HSA-68882 1.938449e-13 12.713 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.359224e-13 12.627 0 0
Axon guidance R-HSA-422475 8.866241e-13 12.052 0 0
Nervous system development R-HSA-9675108 1.656009e-12 11.781 0 0
Cell-Cell communication R-HSA-1500931 3.855360e-12 11.414 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.057155e-12 11.218 0 0
Separation of Sister Chromatids R-HSA-2467813 8.072099e-12 11.093 0 0
Cell junction organization R-HSA-446728 3.068756e-11 10.513 0 0
Signal Transduction R-HSA-162582 6.708556e-11 10.173 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.134371e-11 10.147 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.328635e-10 9.633 0 0
Mitotic Prometaphase R-HSA-68877 8.693589e-10 9.061 0 0
HSF1-dependent transactivation R-HSA-3371571 2.506864e-09 8.601 0 0
Cell Cycle Checkpoints R-HSA-69620 3.468137e-09 8.460 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.989090e-09 8.399 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.986834e-09 8.399 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.986834e-09 8.399 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.132521e-09 8.384 0 0
Regulation of CDH1 Function R-HSA-9764561 4.638326e-09 8.334 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.391423e-09 8.194 0 0
Translation initiation complex formation R-HSA-72649 6.943044e-09 8.158 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.135601e-08 7.945 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.205589e-08 7.919 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.321611e-08 7.879 0 0
Adherens junctions interactions R-HSA-418990 2.103620e-08 7.677 0 0
UCH proteinases R-HSA-5689603 2.371236e-08 7.625 0 0
Cell-cell junction organization R-HSA-421270 3.381506e-08 7.471 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.750669e-08 7.426 0 0
Apoptosis R-HSA-109581 4.366791e-08 7.360 0 0
HSF1 activation R-HSA-3371511 4.889526e-08 7.311 0 0
Attenuation phase R-HSA-3371568 4.906551e-08 7.309 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.541138e-08 7.020 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.059213e-07 6.975 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.229343e-07 6.910 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.195054e-07 6.923 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.195054e-07 6.923 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.246155e-07 6.904 0 0
Apoptotic execution phase R-HSA-75153 1.287720e-07 6.890 0 0
Signaling by ROBO receptors R-HSA-376176 1.383240e-07 6.859 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.766336e-07 6.753 0 0
mRNA Splicing R-HSA-72172 1.825671e-07 6.739 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.932003e-07 6.714 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.014322e-07 6.696 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.059492e-07 6.686 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.690203e-07 6.570 0 0
Cellular Senescence R-HSA-2559583 3.367849e-07 6.473 0 0
Host Interactions of HIV factors R-HSA-162909 4.058945e-07 6.392 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.644157e-07 6.248 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.914886e-07 6.228 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.603803e-07 6.180 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.192042e-07 6.087 1 0
Mitotic Prophase R-HSA-68875 1.348385e-06 5.870 0 0
Influenza Infection R-HSA-168255 1.509256e-06 5.821 0 0
G2/M Transition R-HSA-69275 1.730283e-06 5.762 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.827459e-06 5.738 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.245081e-06 5.649 0 0
Programmed Cell Death R-HSA-5357801 2.185837e-06 5.660 0 0
Interleukin-12 signaling R-HSA-9020591 2.422864e-06 5.616 0 0
Ribosome-associated quality control R-HSA-9948299 2.590731e-06 5.587 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.822325e-06 5.549 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.975276e-06 5.526 0 0
Aggrephagy R-HSA-9646399 3.222503e-06 5.492 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.617419e-06 5.442 0 0
Degradation of CDH1 R-HSA-9766229 4.145312e-06 5.382 0 0
Selective autophagy R-HSA-9663891 4.158580e-06 5.381 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.226036e-06 5.374 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.411118e-06 5.355 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.765989e-06 5.239 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.437205e-06 5.191 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.437205e-06 5.191 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.437205e-06 5.191 0 0
Signaling by RAS mutants R-HSA-6802949 6.437205e-06 5.191 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.447659e-06 5.191 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.447659e-06 5.191 0 0
HIV Infection R-HSA-162906 6.708478e-06 5.173 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.490168e-06 5.126 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.128157e-06 5.090 0 0
mRNA 3'-end processing R-HSA-72187 8.873655e-06 5.052 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.966082e-06 5.047 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.162322e-06 5.038 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.351161e-06 5.029 0 0
Interleukin-12 family signaling R-HSA-447115 9.398831e-06 5.027 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.071607e-05 4.970 0 0
Membrane Trafficking R-HSA-199991 1.032096e-05 4.986 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.053625e-05 4.977 0 0
L1CAM interactions R-HSA-373760 1.075169e-05 4.969 0 0
G2/M Checkpoints R-HSA-69481 1.159613e-05 4.936 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.550224e-05 4.810 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.554702e-05 4.808 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.582936e-05 4.801 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.740799e-05 4.759 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.826352e-05 4.738 0 0
Interferon Signaling R-HSA-913531 2.035637e-05 4.691 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.096188e-05 4.679 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.111445e-05 4.675 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.116758e-05 4.674 0 0
Developmental Biology R-HSA-1266738 2.413971e-05 4.617 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.472598e-05 4.607 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.472598e-05 4.607 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.546174e-05 4.594 0 0
Recycling pathway of L1 R-HSA-437239 2.760016e-05 4.559 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.713318e-05 4.566 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.900907e-05 4.537 0 0
Peptide chain elongation R-HSA-156902 2.965796e-05 4.528 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.206599e-05 4.494 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.219320e-05 4.492 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.332072e-05 4.477 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.596045e-05 4.444 0 0
Autophagy R-HSA-9612973 3.449931e-05 4.462 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.840540e-05 4.416 0 0
Gene expression (Transcription) R-HSA-74160 3.961001e-05 4.402 0 0
PKR-mediated signaling R-HSA-9833482 4.166336e-05 4.380 0 0
Macroautophagy R-HSA-1632852 4.590146e-05 4.338 0 0
Nucleotide Excision Repair R-HSA-5696398 4.876898e-05 4.312 0 0
Chromatin modifying enzymes R-HSA-3247509 5.275312e-05 4.278 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.814333e-05 4.236 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.779647e-05 4.238 0 0
Signaling by Hippo R-HSA-2028269 5.855672e-05 4.232 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.924562e-05 4.227 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.483938e-05 4.188 0 0
Ub-specific processing proteases R-HSA-5689880 6.628340e-05 4.179 0 0
MAP2K and MAPK activation R-HSA-5674135 6.763089e-05 4.170 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.763089e-05 4.170 0 0
EPH-Ephrin signaling R-HSA-2682334 6.783260e-05 4.169 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.665831e-05 4.115 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.295845e-05 4.081 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.325830e-05 4.080 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.717772e-05 4.113 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.549237e-05 4.068 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.628464e-05 4.064 0 0
Signaling by Interleukins R-HSA-449147 8.697517e-05 4.061 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.257451e-05 4.034 0 0
Signaling by NOTCH4 R-HSA-9013694 9.937557e-05 4.003 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.001322e-04 3.999 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.054008e-04 3.977 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.060301e-04 3.975 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.080058e-04 3.967 0 0
Deubiquitination R-HSA-5688426 1.087986e-04 3.963 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.060301e-04 3.975 0 0
Chromatin organization R-HSA-4839726 1.155514e-04 3.937 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.163722e-04 3.934 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.188709e-04 3.925 1 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.195098e-04 3.923 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.208773e-04 3.918 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.255028e-04 3.901 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.348670e-04 3.870 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.400258e-04 3.854 0 0
Viral Infection Pathways R-HSA-9824446 1.424186e-04 3.846 0 0
Gene Silencing by RNA R-HSA-211000 1.507917e-04 3.822 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.534319e-04 3.814 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.667950e-04 3.778 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.098989e-04 3.678 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.056368e-04 3.687 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.119558e-04 3.674 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.422361e-04 3.616 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.466707e-04 3.608 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.584973e-04 3.588 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.993644e-04 3.524 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.106355e-04 3.508 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.194184e-04 3.496 0 0
HCMV Early Events R-HSA-9609690 3.587636e-04 3.445 0 0
HIV Life Cycle R-HSA-162587 3.283224e-04 3.484 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.615807e-04 3.442 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.360430e-04 3.474 0 0
Nuclear import of Rev protein R-HSA-180746 3.336275e-04 3.477 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.357314e-04 3.474 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.336275e-04 3.477 0 0
Stabilization of p53 R-HSA-69541 3.360430e-04 3.474 0 0
Signaling by ALK in cancer R-HSA-9700206 3.357314e-04 3.474 0 0
Ephrin signaling R-HSA-3928664 3.747927e-04 3.426 0 0
Post NMDA receptor activation events R-HSA-438064 3.749795e-04 3.426 0 0
Metalloprotease DUBs R-HSA-5689901 3.843574e-04 3.415 0 0
Gap junction trafficking and regulation R-HSA-157858 3.856445e-04 3.414 0 0
p75NTR signals via NF-kB R-HSA-193639 3.956518e-04 3.403 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.956518e-04 3.403 0 0
Signaling by ERBB2 R-HSA-1227986 4.002517e-04 3.398 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.054841e-04 3.392 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.118651e-04 3.385 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.118651e-04 3.385 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.219745e-04 3.375 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.219745e-04 3.375 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.347106e-04 3.362 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.219745e-04 3.375 0 0
Signaling by VEGF R-HSA-194138 4.578836e-04 3.339 0 0
Regulation of TP53 Activity R-HSA-5633007 4.473940e-04 3.349 0 0
Diseases of programmed cell death R-HSA-9645723 4.328987e-04 3.364 0 0
Regulation of Apoptosis R-HSA-169911 4.219745e-04 3.375 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.186261e-04 3.378 0 0
ESR-mediated signaling R-HSA-8939211 4.199892e-04 3.377 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.186261e-04 3.378 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.186261e-04 3.378 0 0
rRNA processing R-HSA-72312 4.875909e-04 3.312 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.903038e-04 3.310 0 0
S Phase R-HSA-69242 4.908038e-04 3.309 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.960586e-04 3.304 0 0
HATs acetylate histones R-HSA-3214847 5.016873e-04 3.300 0 0
Co-inhibition by PD-1 R-HSA-389948 5.169591e-04 3.287 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.180107e-04 3.286 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.180107e-04 3.286 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.180107e-04 3.286 0 0
Regulation of signaling by CBL R-HSA-912631 5.190149e-04 3.285 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.202951e-04 3.284 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.206688e-04 3.283 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.295370e-04 3.276 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.352001e-04 3.271 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.638683e-04 3.249 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.638683e-04 3.249 0 0
Hedgehog 'off' state R-HSA-5610787 5.713320e-04 3.243 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.793383e-04 3.237 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.660293e-04 3.177 0 0
Orc1 removal from chromatin R-HSA-68949 6.762653e-04 3.170 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.762653e-04 3.170 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.982109e-04 3.223 0 0
Degradation of AXIN R-HSA-4641257 6.595550e-04 3.181 0 0
Eukaryotic Translation Termination R-HSA-72764 6.550714e-04 3.184 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.230071e-04 3.141 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.249280e-04 3.140 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.301390e-04 3.137 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.363970e-04 3.133 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.915520e-04 3.102 0 0
Neurodegenerative Diseases R-HSA-8863678 7.915520e-04 3.102 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.077622e-04 3.093 0 0
DNA Replication R-HSA-69306 8.153000e-04 3.089 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.156405e-04 3.089 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.360844e-04 3.078 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.360844e-04 3.078 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.531880e-04 3.069 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.553372e-04 3.068 0 0
snRNP Assembly R-HSA-191859 8.696101e-04 3.061 0 0
Metabolism of non-coding RNA R-HSA-194441 8.696101e-04 3.061 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.776133e-04 3.057 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.452479e-04 3.024 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.494645e-04 3.023 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.494645e-04 3.023 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.809309e-04 3.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.001793e-03 2.999 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.041155e-03 2.982 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.041155e-03 2.982 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.219915e-03 2.914 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.219915e-03 2.914 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.219915e-03 2.914 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.219915e-03 2.914 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.113577e-03 2.953 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.099908e-03 2.959 0 0
HDACs deacetylate histones R-HSA-3214815 1.137127e-03 2.944 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.053602e-03 2.977 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.141646e-03 2.942 0 0
Gap junction trafficking R-HSA-190828 1.141646e-03 2.942 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.100439e-03 2.958 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.077580e-03 2.968 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.052448e-03 2.978 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.052448e-03 2.978 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.222415e-03 2.913 0 0
PECAM1 interactions R-HSA-210990 1.257638e-03 2.900 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.268077e-03 2.897 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.286649e-03 2.891 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.349181e-03 2.870 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.371326e-03 2.863 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.371326e-03 2.863 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.371326e-03 2.863 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.371326e-03 2.863 0 0
Selenocysteine synthesis R-HSA-2408557 1.382065e-03 2.859 0 0
tRNA processing in the nucleus R-HSA-6784531 1.402622e-03 2.853 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.486726e-03 2.828 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.578493e-03 2.802 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.598403e-03 2.796 0 0
mTORC1-mediated signalling R-HSA-166208 1.627014e-03 2.789 0 0
Semaphorin interactions R-HSA-373755 1.632844e-03 2.787 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.632844e-03 2.787 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.638564e-03 2.786 0 0
Neutrophil degranulation R-HSA-6798695 1.681115e-03 2.774 0 0
Viral mRNA Translation R-HSA-192823 1.744410e-03 2.758 0 0
RNA Polymerase II Transcription R-HSA-73857 1.777660e-03 2.750 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.786745e-03 2.748 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.794849e-03 2.746 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.801573e-03 2.744 0 0
G1/S Transition R-HSA-69206 1.826333e-03 2.738 0 0
NF-kB is activated and signals survival R-HSA-209560 1.851462e-03 2.732 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.888773e-03 2.724 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.921595e-03 2.716 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.921595e-03 2.716 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.921595e-03 2.716 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.923140e-03 2.716 0 0
Degradation of DVL R-HSA-4641258 1.923140e-03 2.716 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.923140e-03 2.716 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.099559e-03 2.678 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.141347e-03 2.669 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.074382e-03 2.683 0 0
Cellular response to hypoxia R-HSA-1234174 2.189899e-03 2.660 0 0
MTOR signalling R-HSA-165159 2.141347e-03 2.669 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.399052e-03 2.620 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.092245e-03 2.679 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.489008e-03 2.604 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.489008e-03 2.604 0 0
Striated Muscle Contraction R-HSA-390522 2.492095e-03 2.603 0 0
Glycolysis R-HSA-70171 2.538530e-03 2.595 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.550830e-03 2.593 0 0
Negative regulation of MET activity R-HSA-6807004 2.585737e-03 2.587 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.585737e-03 2.587 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.642513e-03 2.578 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.826277e-03 2.549 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.830010e-03 2.548 0 0
MAP kinase activation R-HSA-450294 2.878516e-03 2.541 1 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.025838e-03 2.519 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.148873e-03 2.502 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.180799e-03 2.497 0 0
HCMV Infection R-HSA-9609646 3.187381e-03 2.497 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.227746e-03 2.491 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.274561e-03 2.485 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.297947e-03 2.482 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.335816e-03 2.477 0 0
DNA Repair R-HSA-73894 3.421614e-03 2.466 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.660212e-03 2.436 0 0
Oncogene Induced Senescence R-HSA-2559585 3.660212e-03 2.436 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.712139e-03 2.430 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.712139e-03 2.430 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.712139e-03 2.430 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.770311e-03 2.424 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.880156e-03 2.411 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.943545e-03 2.404 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.977118e-03 2.400 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.977118e-03 2.400 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.977118e-03 2.400 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.050791e-03 2.392 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.976763e-03 2.303 1 1
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.123899e-03 2.385 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.247162e-03 2.372 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.247162e-03 2.372 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.247162e-03 2.372 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.311226e-03 2.365 0 0
Cellular response to starvation R-HSA-9711097 4.270048e-03 2.370 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.801941e-03 2.319 1 0
Degradation of CRY and PER proteins R-HSA-9932298 4.700717e-03 2.328 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.892486e-03 2.310 0 0
Regulation of KIT signaling R-HSA-1433559 4.976763e-03 2.303 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.700717e-03 2.328 0 0
Signaling by Hedgehog R-HSA-5358351 4.048240e-03 2.393 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.700717e-03 2.328 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.189455e-03 2.378 0 0
SARS-CoV Infections R-HSA-9679506 4.948527e-03 2.306 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.992937e-03 2.302 0 0
Smooth Muscle Contraction R-HSA-445355 4.992937e-03 2.302 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.124203e-03 2.290 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.124203e-03 2.290 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.341911e-03 2.272 0 0
PCP/CE pathway R-HSA-4086400 5.376749e-03 2.269 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.661536e-03 2.247 0 0
Vesicle-mediated transport R-HSA-5653656 5.701003e-03 2.244 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.753180e-03 2.240 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.756011e-03 2.240 0 0
Integrin signaling R-HSA-354192 5.765596e-03 2.239 0 0
Synthesis of DNA R-HSA-69239 5.856312e-03 2.232 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.892305e-03 2.230 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.196451e-03 2.208 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.464346e-03 2.189 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.546909e-03 2.184 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.605090e-03 2.180 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.605090e-03 2.180 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.795498e-03 2.168 0 0
Translesion Synthesis by POLH R-HSA-110320 6.815967e-03 2.166 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.032415e-03 2.153 0 0
Circadian clock R-HSA-9909396 7.131580e-03 2.147 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.237382e-03 2.140 0 0
Chromosome Maintenance R-HSA-73886 7.492166e-03 2.125 0 0
G1 Phase R-HSA-69236 7.524394e-03 2.124 0 0
Cyclin D associated events in G1 R-HSA-69231 7.524394e-03 2.124 0 0
RMTs methylate histone arginines R-HSA-3214858 7.524394e-03 2.124 0 0
Late endosomal microautophagy R-HSA-9615710 7.576153e-03 2.121 0 0
Platelet degranulation R-HSA-114608 7.639300e-03 2.117 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.755995e-03 2.110 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.791251e-03 2.108 1 0
MyD88-independent TLR4 cascade R-HSA-166166 7.791251e-03 2.108 1 0
TCR signaling R-HSA-202403 7.791251e-03 2.108 0 0
Protein ubiquitination R-HSA-8852135 7.894542e-03 2.103 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.925998e-03 2.101 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.925998e-03 2.101 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.174626e-03 2.088 0 0
Deadenylation of mRNA R-HSA-429947 8.174626e-03 2.088 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.174626e-03 2.088 0 0
RAF activation R-HSA-5673000 8.192898e-03 2.087 0 0
Gap junction assembly R-HSA-190861 8.192898e-03 2.087 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.192898e-03 2.087 0 0
Mitophagy R-HSA-5205647 8.192898e-03 2.087 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.435290e-03 2.074 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.435290e-03 2.074 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.451185e-03 2.073 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.554594e-03 2.068 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.554594e-03 2.068 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.599402e-03 2.066 0 0
Prolonged ERK activation events R-HSA-169893 8.599402e-03 2.066 0 0
Nucleosome assembly R-HSA-774815 8.717177e-03 2.060 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.717177e-03 2.060 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.717177e-03 2.060 0 0
DAG and IP3 signaling R-HSA-1489509 8.717177e-03 2.060 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.717177e-03 2.060 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.775766e-03 2.057 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.775766e-03 2.057 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.960757e-03 2.048 0 0
Formation of annular gap junctions R-HSA-196025 8.960757e-03 2.048 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.960757e-03 2.048 0 0
Adrenoceptors R-HSA-390696 8.960757e-03 2.048 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.960757e-03 2.048 0 0
Activation of BH3-only proteins R-HSA-114452 9.099674e-03 2.041 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.204381e-03 2.036 0 0
Interleukin-17 signaling R-HSA-448424 9.204381e-03 2.036 1 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.105072e-02 1.957 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.066225e-02 1.972 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.066225e-02 1.972 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.066225e-02 1.972 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.202562e-02 1.920 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.084709e-02 1.965 0 0
Meiotic synapsis R-HSA-1221632 1.137638e-02 1.944 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.798027e-03 2.009 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.206554e-02 1.918 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.063412e-02 1.973 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.246466e-02 1.904 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.063412e-02 1.973 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.100374e-02 1.958 0 0
Long-term potentiation R-HSA-9620244 9.960633e-03 2.002 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.202562e-02 1.920 0 0
Calmodulin induced events R-HSA-111933 1.134677e-02 1.945 0 0
CaM pathway R-HSA-111997 1.134677e-02 1.945 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.967151e-03 2.001 0 0
Hedgehog 'on' state R-HSA-5632684 1.032118e-02 1.986 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.155398e-02 1.937 0 0
Muscle contraction R-HSA-397014 1.132413e-02 1.946 0 0
ABC-family proteins mediated transport R-HSA-382556 9.695528e-03 2.013 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.248808e-02 1.904 0 0
Kinesins R-HSA-983189 1.252325e-02 1.902 0 0
ARMS-mediated activation R-HSA-170984 1.264193e-02 1.898 0 0
Gap junction degradation R-HSA-190873 1.264193e-02 1.898 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.264193e-02 1.898 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.264193e-02 1.898 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.264193e-02 1.898 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.309802e-02 1.883 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.309802e-02 1.883 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.309802e-02 1.883 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.309802e-02 1.883 0 0
Ca-dependent events R-HSA-111996 1.332826e-02 1.875 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.332826e-02 1.875 0 0
PTEN Regulation R-HSA-6807070 1.350182e-02 1.870 0 0
Signaling by MET R-HSA-6806834 1.356504e-02 1.868 0 0
Telomere Maintenance R-HSA-157579 1.367081e-02 1.864 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.367081e-02 1.864 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.371461e-02 1.863 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.371461e-02 1.863 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.371461e-02 1.863 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.371461e-02 1.863 0 0
Maturation of protein E R-HSA-9683683 1.371461e-02 1.863 0 0
Maturation of protein E R-HSA-9694493 1.371461e-02 1.863 0 0
Formation of axial mesoderm R-HSA-9796292 1.393994e-02 1.856 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.397601e-02 1.855 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.455179e-02 1.837 0 0
Signaling by NOTCH3 R-HSA-9012852 1.461340e-02 1.835 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.496768e-02 1.825 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.496768e-02 1.825 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.496768e-02 1.825 1 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.509120e-02 1.821 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.509120e-02 1.821 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.509120e-02 1.821 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.545926e-02 1.811 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.568775e-02 1.804 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.590297e-02 1.799 0 0
Translation R-HSA-72766 1.639435e-02 1.785 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.647666e-02 1.783 0 0
Glucose metabolism R-HSA-70326 1.691001e-02 1.772 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.708981e-02 1.767 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.721385e-02 1.764 0 0
Regulation of CDH11 function R-HSA-9762292 1.723000e-02 1.764 0 0
Josephin domain DUBs R-HSA-5689877 1.723000e-02 1.764 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.723000e-02 1.764 0 0
Pexophagy R-HSA-9664873 1.723000e-02 1.764 0 0
MAPK family signaling cascades R-HSA-5683057 1.751674e-02 1.757 0 0
Signaling by PTK6 R-HSA-8848021 1.767760e-02 1.753 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.767760e-02 1.753 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.771516e-02 1.752 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.790197e-02 1.747 0 0
Interleukin-1 signaling R-HSA-9020702 1.944722e-02 1.711 1 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.987353e-02 1.702 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.987353e-02 1.702 0 0
Nef and signal transduction R-HSA-164944 2.013234e-02 1.696 0 0
DNA methylation R-HSA-5334118 2.013655e-02 1.696 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.033765e-02 1.692 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.033765e-02 1.692 0 0
Dual Incision in GG-NER R-HSA-5696400 2.046259e-02 1.689 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.046259e-02 1.689 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.068047e-02 1.684 0 0
Dual incision in TC-NER R-HSA-6782135 2.074123e-02 1.683 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.110065e-02 1.676 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.144468e-02 1.669 0 0
RNA Polymerase I Transcription R-HSA-73864 2.144468e-02 1.669 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.170817e-02 1.663 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.206424e-02 1.656 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.206424e-02 1.656 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.206424e-02 1.656 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.206424e-02 1.656 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.206424e-02 1.656 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.206424e-02 1.656 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.257357e-02 1.646 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.257357e-02 1.646 0 0
Translesion synthesis by REV1 R-HSA-110312 2.257357e-02 1.646 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.257357e-02 1.646 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.316179e-02 1.635 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.323564e-02 1.634 0 0
Developmental Cell Lineages R-HSA-9734767 2.467285e-02 1.608 0 0
Regulation of gap junction activity R-HSA-191650 3.163731e-02 1.500 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.163731e-02 1.500 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.813183e-02 1.551 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.942812e-02 1.531 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.715248e-02 1.430 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.715248e-02 1.430 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.715248e-02 1.430 0 0
Translesion synthesis by POLI R-HSA-5656121 2.800194e-02 1.553 0 0
Disorders of Developmental Biology R-HSA-9675151 3.422725e-02 1.466 0 0
Translesion synthesis by POLK R-HSA-5655862 3.422725e-02 1.466 0 0
Formation of definitive endoderm R-HSA-9823730 2.555818e-02 1.592 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.555818e-02 1.592 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.161745e-02 1.500 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.677798e-02 1.434 0 0
Packaging Of Telomere Ends R-HSA-171306 3.677798e-02 1.434 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.710950e-02 1.567 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.521000e-02 1.598 0 0
Centrosome maturation R-HSA-380287 3.044493e-02 1.516 0 0
DNA Damage Bypass R-HSA-73893 3.209554e-02 1.494 0 0
Signaling by EGFR R-HSA-177929 3.375365e-02 1.472 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.095462e-02 1.509 0 0
Co-stimulation by CD28 R-HSA-389356 2.864572e-02 1.543 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.693167e-02 1.433 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.375365e-02 1.472 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.160244e-02 1.500 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.813183e-02 1.551 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.160244e-02 1.500 0 0
Downstream TCR signaling R-HSA-202424 3.693167e-02 1.433 0 0
Myogenesis R-HSA-525793 3.161745e-02 1.500 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.163731e-02 1.500 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.942812e-02 1.531 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.588440e-02 1.587 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.716840e-02 1.566 1 0
ER to Golgi Anterograde Transport R-HSA-199977 2.544938e-02 1.594 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.715248e-02 1.430 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.334453e-02 1.477 0 0
Nephrin family interactions R-HSA-373753 2.555818e-02 1.592 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.422725e-02 1.466 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.061941e-02 1.514 0 0
Generic Transcription Pathway R-HSA-212436 2.872494e-02 1.542 0 0
Glycogen synthesis R-HSA-3322077 2.555818e-02 1.592 0 0
Signal transduction by L1 R-HSA-445144 2.555818e-02 1.592 0 0
Cellular response to chemical stress R-HSA-9711123 3.146292e-02 1.502 0 0
Signaling by NOTCH R-HSA-157118 3.539756e-02 1.451 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.666482e-02 1.574 0 0
Regulation of PTEN localization R-HSA-8948747 2.813183e-02 1.551 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.677798e-02 1.434 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.160244e-02 1.500 0 0
Immune System R-HSA-168256 3.606811e-02 1.443 1 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.626647e-02 1.440 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.862640e-02 1.543 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.168857e-02 1.499 0 0
Signaling by ERBB4 R-HSA-1236394 2.773572e-02 1.557 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.813183e-02 1.551 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.626647e-02 1.440 0 0
Signaling by NTRKs R-HSA-166520 2.716840e-02 1.566 0 0
Infectious disease R-HSA-5663205 3.199740e-02 1.495 0 0
Negative regulation of FLT3 R-HSA-9706369 2.800194e-02 1.553 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.160244e-02 1.500 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.862640e-02 1.543 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.946386e-02 1.531 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.631329e-02 1.440 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.967496e-02 1.528 0 0
Type I hemidesmosome assembly R-HSA-446107 3.777624e-02 1.423 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.777624e-02 1.423 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.777624e-02 1.423 0 0
Proteasome assembly R-HSA-9907900 3.786813e-02 1.422 0 0
ABC transporter disorders R-HSA-5619084 3.974143e-02 1.401 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.976624e-02 1.400 0 0
Meiosis R-HSA-1500620 3.996742e-02 1.398 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.996742e-02 1.398 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.128203e-02 1.384 0 0
Somitogenesis R-HSA-9824272 4.235141e-02 1.373 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.266437e-02 1.370 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.266437e-02 1.370 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.266437e-02 1.370 0 0
Signaling by WNT R-HSA-195721 4.290241e-02 1.368 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.421270e-02 1.354 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.430195e-02 1.354 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.601075e-02 1.337 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.601075e-02 1.337 0 0
Frs2-mediated activation R-HSA-170968 4.601075e-02 1.337 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.612245e-02 1.336 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.612245e-02 1.336 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.612245e-02 1.336 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 4.612245e-02 1.336 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 4.612245e-02 1.336 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 4.612245e-02 1.336 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.612245e-02 1.336 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.630742e-02 1.334 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.630742e-02 1.334 0 0
Protein folding R-HSA-391251 4.667419e-02 1.331 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.680010e-02 1.330 0 0
Signaling by NOTCH2 R-HSA-1980145 4.696052e-02 1.328 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.703719e-02 1.328 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.718760e-02 1.326 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.758815e-02 1.323 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.909105e-02 1.309 0 0
Calcineurin activates NFAT R-HSA-2025928 4.909105e-02 1.309 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.909105e-02 1.309 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.919077e-02 1.308 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.969251e-02 1.304 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.969251e-02 1.304 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.974704e-02 1.303 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.016247e-02 1.300 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.016247e-02 1.300 0 0
FLT3 Signaling R-HSA-9607240 5.016247e-02 1.300 0 0
DNA Double Strand Break Response R-HSA-5693606 5.062951e-02 1.296 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.069956e-02 1.295 0 0
Signalling to ERKs R-HSA-187687 5.301799e-02 1.276 0 0
Interleukin-1 family signaling R-HSA-446652 5.390563e-02 1.268 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.406965e-02 1.267 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.406965e-02 1.267 1 0
PLC beta mediated events R-HSA-112043 5.475270e-02 1.262 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.519466e-02 1.258 0 0
Signaling by TGFB family members R-HSA-9006936 5.540755e-02 1.256 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.602114e-02 1.252 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.602114e-02 1.252 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.697670e-02 1.244 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.796965e-02 1.237 0 0
Rap1 signalling R-HSA-392517 5.796965e-02 1.237 0 0
ER-Phagosome pathway R-HSA-1236974 5.889142e-02 1.230 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.917769e-02 1.228 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.008601e-02 1.221 1 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.206728e-02 1.207 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.206728e-02 1.207 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.206728e-02 1.207 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.206728e-02 1.207 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.222988e-02 1.206 0 0
Depyrimidination R-HSA-73928 6.222988e-02 1.206 0 0
EGFR downregulation R-HSA-182971 6.295261e-02 1.201 0 0
Budding and maturation of HIV virion R-HSA-162588 6.295261e-02 1.201 0 0
Trafficking of AMPA receptors R-HSA-399719 6.295261e-02 1.201 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.295261e-02 1.201 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.323824e-02 1.199 0 0
Base Excision Repair R-HSA-73884 6.331139e-02 1.199 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.374866e-02 1.196 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.410682e-02 1.193 1 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.483431e-02 1.188 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.507795e-02 1.187 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.507795e-02 1.187 1 0
Sema4D in semaphorin signaling R-HSA-400685 6.583446e-02 1.182 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.660577e-02 1.176 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.660577e-02 1.176 0 0
Cleavage of the damaged purine R-HSA-110331 6.660577e-02 1.176 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.718657e-02 1.173 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.718657e-02 1.173 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.718657e-02 1.173 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.762650e-02 1.170 0 0
Selenoamino acid metabolism R-HSA-2408522 6.837086e-02 1.165 0 0
Defective pyroptosis R-HSA-9710421 6.891014e-02 1.162 0 0
MHC class II antigen presentation R-HSA-2132295 6.906950e-02 1.161 0 0
Opioid Signalling R-HSA-111885 6.987725e-02 1.156 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.055003e-02 1.152 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.089527e-02 1.149 0 0
G0 and Early G1 R-HSA-1538133 7.093961e-02 1.149 0 0
MET promotes cell motility R-HSA-8875878 7.414975e-02 1.130 0 0
Depurination R-HSA-73927 7.414975e-02 1.130 0 0
Sensory processing of sound R-HSA-9659379 7.528933e-02 1.123 0 0
Regulation of TP53 Expression R-HSA-6804754 7.623443e-02 1.118 0 0
Diseases of cellular response to stress R-HSA-9675132 7.623443e-02 1.118 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.623443e-02 1.118 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.666535e-02 1.115 0 0
Meiotic recombination R-HSA-912446 7.695284e-02 1.114 0 0
Basigin interactions R-HSA-210991 7.816097e-02 1.107 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.816097e-02 1.107 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.949550e-02 1.100 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.949550e-02 1.100 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.951624e-02 1.100 0 0
Nuclear RNA decay R-HSA-9930044 7.951624e-02 1.100 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.951624e-02 1.100 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.951624e-02 1.100 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.951624e-02 1.100 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.203135e-02 1.086 1 0
Cilium Assembly R-HSA-5617833 8.268327e-02 1.083 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.358788e-02 1.078 0 0
CREB phosphorylation R-HSA-199920 8.375507e-02 1.077 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.375507e-02 1.077 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.406260e-02 1.075 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.479704e-02 1.072 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.479704e-02 1.072 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.479704e-02 1.072 1 1
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.479704e-02 1.072 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.687045e-02 1.061 0 0
Death Receptor Signaling R-HSA-73887 8.904051e-02 1.050 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.956468e-02 1.048 0 0
Assembly Of The HIV Virion R-HSA-175474 8.956468e-02 1.048 0 0
G-protein mediated events R-HSA-112040 8.986046e-02 1.046 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.038894e-02 1.044 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.093053e-02 1.041 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 9.281938e-02 1.032 0 0
Integration of provirus R-HSA-162592 9.281938e-02 1.032 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.292288e-02 1.032 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.292288e-02 1.032 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.292288e-02 1.032 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.292288e-02 1.032 0 0
HIV elongation arrest and recovery R-HSA-167287 9.533183e-02 1.021 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.533183e-02 1.021 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.533183e-02 1.021 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.746280e-02 1.011 1 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.843521e-02 1.007 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.843521e-02 1.007 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.945918e-02 1.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.952675e-02 1.002 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.981223e-02 1.001 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.981223e-02 1.001 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.018217e-01 0.992 0 0
HCMV Late Events R-HSA-9610379 1.027752e-01 0.988 0 0
Interferon alpha/beta signaling R-HSA-909733 1.029920e-01 0.987 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.070389e-01 0.970 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.070389e-01 0.970 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.070389e-01 0.970 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.070389e-01 0.970 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.026260e-01 0.693 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 2.026260e-01 0.693 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.026260e-01 0.693 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.026260e-01 0.693 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.026260e-01 0.693 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.026260e-01 0.693 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.026260e-01 0.693 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.026260e-01 0.693 0 0
MET interacts with TNS proteins R-HSA-8875513 1.108300e-01 0.955 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.108300e-01 0.955 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.486053e-01 0.828 0 0
NADE modulates death signalling R-HSA-205025 1.486053e-01 0.828 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.486053e-01 0.828 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.486053e-01 0.828 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.486053e-01 0.828 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.486053e-01 0.828 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.486053e-01 0.828 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.060737e-01 0.974 0 0
Recycling of eIF2:GDP R-HSA-72731 1.060737e-01 0.974 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.060737e-01 0.974 0 0
IRS activation R-HSA-74713 1.884843e-01 0.725 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.884843e-01 0.725 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.884843e-01 0.725 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.884843e-01 0.725 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.304233e-01 0.885 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.304233e-01 0.885 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.304233e-01 0.885 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.104415e-01 0.957 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.104415e-01 0.957 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.565091e-01 0.805 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.565091e-01 0.805 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.565091e-01 0.805 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.840338e-01 0.735 0 0
2-LTR circle formation R-HSA-164843 1.840338e-01 0.735 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.496542e-01 0.825 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.229731e-01 0.910 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.709966e-01 0.767 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.709966e-01 0.767 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.709966e-01 0.767 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.394901e-01 0.855 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.065568e-01 0.972 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.065568e-01 0.972 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.569169e-01 0.804 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.933178e-01 0.714 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.933178e-01 0.714 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.117000e-01 0.952 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.487108e-01 0.828 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.643369e-01 0.784 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.596827e-01 0.797 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.184569e-01 0.926 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.942059e-01 0.712 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.294262e-01 0.888 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.104415e-01 0.957 0 0
Activation of the pre-replicative complex R-HSA-68962 1.184569e-01 0.926 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.579941e-01 0.801 0 0
DCC mediated attractive signaling R-HSA-418885 1.709966e-01 0.767 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.486053e-01 0.828 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.060737e-01 0.974 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.496542e-01 0.825 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.020508e-01 0.695 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.182301e-01 0.927 0 0
FOXO-mediated transcription R-HSA-9614085 1.269754e-01 0.896 0 0
TNF signaling R-HSA-75893 1.164178e-01 0.934 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.565091e-01 0.805 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.229731e-01 0.910 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.434500e-01 0.843 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.254746e-01 0.901 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.455695e-01 0.837 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.229731e-01 0.910 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.394901e-01 0.855 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.733862e-01 0.761 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.733862e-01 0.761 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.088314e-01 0.680 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.548815e-01 0.810 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.548815e-01 0.810 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.548815e-01 0.810 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.548815e-01 0.810 0 0
Homology Directed Repair R-HSA-5693538 1.207410e-01 0.918 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.556454e-01 0.808 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.447144e-01 0.839 0 0
G alpha (z) signalling events R-HSA-418597 1.827682e-01 0.738 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.884843e-01 0.725 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.184569e-01 0.926 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.394901e-01 0.855 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.513787e-01 0.820 0 0
Toll-like Receptor Cascades R-HSA-168898 1.206281e-01 0.919 1 0
The NLRP3 inflammasome R-HSA-844456 1.394901e-01 0.855 0 0
G alpha (12/13) signalling events R-HSA-416482 1.835567e-01 0.736 0 0
Ion homeostasis R-HSA-5578775 1.164178e-01 0.934 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.884843e-01 0.725 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.065568e-01 0.972 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.872701e-01 0.728 0 0
Protein methylation R-HSA-8876725 1.709966e-01 0.767 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.287970e-01 0.890 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.310127e-01 0.883 0 0
Adaptive Immune System R-HSA-1280218 2.048715e-01 0.689 1 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.579941e-01 0.801 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.766713e-01 0.753 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.278474e-01 0.893 0 0
NGF-stimulated transcription R-HSA-9031628 1.089141e-01 0.963 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.026260e-01 0.693 0 0
Inhibition of PKR R-HSA-169131 2.026260e-01 0.693 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.108300e-01 0.955 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.884843e-01 0.725 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.294262e-01 0.888 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.074315e-01 0.969 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.065568e-01 0.972 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.088314e-01 0.680 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.874510e-01 0.727 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.548815e-01 0.810 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.280599e-01 0.893 0 0
PERK regulates gene expression R-HSA-381042 2.026831e-01 0.693 0 0
Amyloid fiber formation R-HSA-977225 1.405033e-01 0.852 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.126135e-01 0.948 0 0
Gastrulation R-HSA-9758941 1.446044e-01 0.840 0 0
Glycogen metabolism R-HSA-8982491 1.686648e-01 0.773 0 0
Glycogen storage diseases R-HSA-3229121 1.074315e-01 0.969 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.437396e-01 0.842 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.025384e-01 0.693 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.872701e-01 0.728 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.060737e-01 0.974 0 0
TGFBR3 expression R-HSA-9839394 1.434500e-01 0.843 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.194547e-01 0.923 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.884843e-01 0.725 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.104415e-01 0.957 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.104415e-01 0.957 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.487108e-01 0.828 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.751812e-01 0.757 0 0
NrCAM interactions R-HSA-447038 1.884843e-01 0.725 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.556454e-01 0.808 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.748833e-01 0.757 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.270435e-01 0.896 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.772816e-01 0.751 0 0
Signaling by Leptin R-HSA-2586552 1.840338e-01 0.735 0 0
Translation of Structural Proteins R-HSA-9683701 1.961051e-01 0.708 0 0
Regulation of BACH1 activity R-HSA-9708530 1.933178e-01 0.714 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.104720e-01 0.677 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.104720e-01 0.677 0 0
Hemostasis R-HSA-109582 2.124698e-01 0.673 0 0
Interleukin-2 signaling R-HSA-9020558 2.127059e-01 0.672 0 0
FGFR2 alternative splicing R-HSA-6803529 2.139097e-01 0.670 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.139097e-01 0.670 0 0
Signaling by KIT in disease R-HSA-9669938 2.139097e-01 0.670 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.164789e-01 0.665 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.164789e-01 0.665 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.164789e-01 0.665 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.172261e-01 0.663 0 0
G1/S-Specific Transcription R-HSA-69205 2.185622e-01 0.660 0 0
RET signaling R-HSA-8853659 2.185622e-01 0.660 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.248395e-01 0.648 0 0
Signaling by SCF-KIT R-HSA-1433557 2.252312e-01 0.647 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.252312e-01 0.647 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.266157e-01 0.645 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.266157e-01 0.645 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.266157e-01 0.645 0 0
Interleukin-37 signaling R-HSA-9008059 2.266157e-01 0.645 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.295843e-01 0.639 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.295843e-01 0.639 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.295843e-01 0.639 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.295843e-01 0.639 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.295843e-01 0.639 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.295843e-01 0.639 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.295843e-01 0.639 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.342091e-01 0.630 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.342091e-01 0.630 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.342091e-01 0.630 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.342091e-01 0.630 0 0
Syndecan interactions R-HSA-3000170 2.342091e-01 0.630 0 0
Growth hormone receptor signaling R-HSA-982772 2.342091e-01 0.630 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.365005e-01 0.626 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.403403e-01 0.619 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.403403e-01 0.619 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.403403e-01 0.619 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.403403e-01 0.619 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.403403e-01 0.619 0 0
Netrin-1 signaling R-HSA-373752 2.403517e-01 0.619 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.422463e-01 0.616 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.422463e-01 0.616 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.422463e-01 0.616 0 0
Neurexins and neuroligins R-HSA-6794361 2.440022e-01 0.613 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.444897e-01 0.612 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.444897e-01 0.612 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.444897e-01 0.612 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.487357e-01 0.604 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.515562e-01 0.599 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.550192e-01 0.593 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.550192e-01 0.593 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.584363e-01 0.588 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.605325e-01 0.584 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.647638e-01 0.577 0 0
PKA activation in glucagon signalling R-HSA-164378 2.647638e-01 0.577 0 0
GAB1 signalosome R-HSA-180292 2.647638e-01 0.577 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.667620e-01 0.574 0 0
Disorders of transmembrane transporters R-HSA-5619115 2.678592e-01 0.572 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.685866e-01 0.571 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.685866e-01 0.571 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.711876e-01 0.567 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.711876e-01 0.567 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.711876e-01 0.567 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.711876e-01 0.567 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.711876e-01 0.567 0 0
Neurofascin interactions R-HSA-447043 2.711876e-01 0.567 0 0
Signaling by TGFBR3 R-HSA-9839373 2.715476e-01 0.566 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.723922e-01 0.565 0 0
Pervasive developmental disorders R-HSA-9005895 2.723922e-01 0.565 0 0
Disorders of Nervous System Development R-HSA-9697154 2.723922e-01 0.565 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.723922e-01 0.565 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.723922e-01 0.565 0 0
Mitochondrial protein import R-HSA-1268020 2.737785e-01 0.563 0 0
Tight junction interactions R-HSA-420029 2.762549e-01 0.559 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.762549e-01 0.559 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.762549e-01 0.559 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.825256e-01 0.549 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.844036e-01 0.546 0 0
HIV Transcription Elongation R-HSA-167169 2.859150e-01 0.544 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.859150e-01 0.544 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.859150e-01 0.544 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.875564e-01 0.541 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.879861e-01 0.541 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.879861e-01 0.541 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.879861e-01 0.541 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.879861e-01 0.541 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.879861e-01 0.541 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.879861e-01 0.541 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.879861e-01 0.541 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.879861e-01 0.541 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.879861e-01 0.541 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.879861e-01 0.541 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.879861e-01 0.541 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.879861e-01 0.541 0 0
XAV939 stabilizes AXIN R-HSA-5545619 2.879861e-01 0.541 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.879861e-01 0.541 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.879861e-01 0.541 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.879861e-01 0.541 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.879861e-01 0.541 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.896146e-01 0.538 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.896146e-01 0.538 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.978316e-01 0.526 0 0
TRP channels R-HSA-3295583 2.978316e-01 0.526 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.978316e-01 0.526 0 0
Signaling by FGFR2 R-HSA-5654738 2.986290e-01 0.525 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.018191e-01 0.520 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.018191e-01 0.520 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.018191e-01 0.520 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.018191e-01 0.520 0 0
Reproduction R-HSA-1474165 3.022599e-01 0.520 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.029001e-01 0.519 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.029001e-01 0.519 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.029001e-01 0.519 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.029001e-01 0.519 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.029001e-01 0.519 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.029001e-01 0.519 0 0
Maturation of nucleoprotein R-HSA-9683610 3.029001e-01 0.519 0 0
NRAGE signals death through JNK R-HSA-193648 3.032100e-01 0.518 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.037937e-01 0.517 0 0
GPER1 signaling R-HSA-9634597 3.037937e-01 0.517 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.127159e-01 0.505 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.127159e-01 0.505 0 0
SOS-mediated signalling R-HSA-112412 3.127159e-01 0.505 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.127159e-01 0.505 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.127159e-01 0.505 0 0
CHL1 interactions R-HSA-447041 3.127159e-01 0.505 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.127159e-01 0.505 0 0
tRNA processing R-HSA-72306 3.137201e-01 0.503 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.147630e-01 0.502 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.147630e-01 0.502 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.147630e-01 0.502 0 0
Signaling by NODAL R-HSA-1181150 3.147630e-01 0.502 0 0
Cristae formation R-HSA-8949613 3.196665e-01 0.495 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.196665e-01 0.495 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.300489e-01 0.481 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.335478e-01 0.477 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.335478e-01 0.477 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.335478e-01 0.477 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.335478e-01 0.477 0 0
Signal regulatory protein family interactions R-HSA-391160 3.335478e-01 0.477 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.335478e-01 0.477 0 0
Inositol phosphate metabolism R-HSA-1483249 3.340224e-01 0.476 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.400853e-01 0.468 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.400853e-01 0.468 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.400853e-01 0.468 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.416788e-01 0.466 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.416788e-01 0.466 0 0
Inflammasomes R-HSA-622312 3.416788e-01 0.466 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.416788e-01 0.466 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.456582e-01 0.461 0 0
Extension of Telomeres R-HSA-180786 3.496150e-01 0.456 0 0
Regulation of beta-cell development R-HSA-186712 3.496150e-01 0.456 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.537088e-01 0.451 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.537088e-01 0.451 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.537088e-01 0.451 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.537088e-01 0.451 0 0
Potential therapeutics for SARS R-HSA-9679191 3.540291e-01 0.451 0 0
Signaling by NOTCH1 R-HSA-1980143 3.556901e-01 0.449 0 0
TBC/RABGAPs R-HSA-8854214 3.573344e-01 0.447 0 0
Signaling by FGFR4 R-HSA-5654743 3.573344e-01 0.447 0 0
IRE1alpha activates chaperones R-HSA-381070 3.594039e-01 0.444 0 0
Transcription of the HIV genome R-HSA-167172 3.604304e-01 0.443 0 0
Regulated Necrosis R-HSA-5218859 3.604304e-01 0.443 0 0
RUNX2 regulates bone development R-HSA-8941326 3.608558e-01 0.443 0 0
FLT3 signaling in disease R-HSA-9682385 3.608558e-01 0.443 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.637911e-01 0.439 0 0
mRNA Capping R-HSA-72086 3.637911e-01 0.439 0 0
Platelet calcium homeostasis R-HSA-418360 3.637911e-01 0.439 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.641348e-01 0.439 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.641348e-01 0.439 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.641348e-01 0.439 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.641348e-01 0.439 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.642127e-01 0.439 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.642127e-01 0.439 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.642127e-01 0.439 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.642127e-01 0.439 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.642127e-01 0.439 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.642127e-01 0.439 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.642127e-01 0.439 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.642127e-01 0.439 0 0
C6 deamination of adenosine R-HSA-75102 3.642127e-01 0.439 0 0
Signalling to ERK5 R-HSA-198765 3.642127e-01 0.439 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.642127e-01 0.439 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.642127e-01 0.439 0 0
Metabolism of polyamines R-HSA-351202 3.653169e-01 0.437 0 0
Ribavirin ADME R-HSA-9755088 3.654652e-01 0.437 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.752811e-01 0.426 0 0
Amine ligand-binding receptors R-HSA-375280 3.755002e-01 0.425 0 0
Protein localization R-HSA-9609507 3.838318e-01 0.416 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.846979e-01 0.415 0 0
Notch-HLH transcription pathway R-HSA-350054 3.907940e-01 0.408 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.907940e-01 0.408 0 0
Disease R-HSA-1643685 3.912329e-01 0.408 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.914052e-01 0.407 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.937071e-01 0.405 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.937071e-01 0.405 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.937071e-01 0.405 0 0
Signaling by FGFR3 R-HSA-5654741 3.937071e-01 0.405 0 0
Lipophagy R-HSA-9613354 3.938051e-01 0.405 0 0
Interleukin-21 signaling R-HSA-9020958 3.938051e-01 0.405 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.938051e-01 0.405 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.938051e-01 0.405 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.938051e-01 0.405 0 0
Unwinding of DNA R-HSA-176974 3.938051e-01 0.405 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.938051e-01 0.405 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.938051e-01 0.405 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.938051e-01 0.405 0 0
Interleukin-1 processing R-HSA-448706 3.938051e-01 0.405 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.938051e-01 0.405 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.944830e-01 0.404 0 0
Phosphorylation of the APC/C R-HSA-176412 3.944830e-01 0.404 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.944830e-01 0.404 0 0
Heme signaling R-HSA-9707616 3.969074e-01 0.401 0 0
Innate Immune System R-HSA-168249 4.064869e-01 0.391 1 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.119151e-01 0.385 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.119151e-01 0.385 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.119151e-01 0.385 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.119151e-01 0.385 0 0
Rab regulation of trafficking R-HSA-9007101 4.144653e-01 0.383 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.244358e-01 0.372 0 0
DNA strand elongation R-HSA-69190 4.300040e-01 0.367 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.307780e-01 0.366 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.322826e-01 0.364 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.322826e-01 0.364 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.322826e-01 0.364 0 0
Axonal growth stimulation R-HSA-209563 4.322826e-01 0.364 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.322826e-01 0.364 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.322826e-01 0.364 0 0
Binding and entry of HIV virion R-HSA-173107 4.327273e-01 0.364 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.327273e-01 0.364 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.327273e-01 0.364 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.327273e-01 0.364 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.327273e-01 0.364 0 0
PI3K/AKT activation R-HSA-198203 4.327273e-01 0.364 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.327273e-01 0.364 0 0
Signal attenuation R-HSA-74749 4.327273e-01 0.364 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.327273e-01 0.364 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.327273e-01 0.364 0 0
Signaling by FGFR1 R-HSA-5654736 4.378661e-01 0.359 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.409063e-01 0.356 0 0
Intraflagellar transport R-HSA-5620924 4.481835e-01 0.349 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.481835e-01 0.349 0 0
Gluconeogenesis R-HSA-70263 4.481835e-01 0.349 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.518134e-01 0.345 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.576731e-01 0.339 0 0
Signaling by FGFR R-HSA-190236 4.629611e-01 0.334 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.655153e-01 0.332 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.702673e-01 0.328 0 0
vRNP Assembly R-HSA-192905 4.702673e-01 0.328 0 0
Suppression of apoptosis R-HSA-9635465 4.702673e-01 0.328 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.733929e-01 0.325 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.733929e-01 0.325 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.826323e-01 0.316 0 0
Polo-like kinase mediated events R-HSA-156711 4.826323e-01 0.316 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.826323e-01 0.316 0 0
Platelet sensitization by LDL R-HSA-432142 4.826323e-01 0.316 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.826323e-01 0.316 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.826323e-01 0.316 0 0
MET activates PTK2 signaling R-HSA-8874081 4.897244e-01 0.310 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.897244e-01 0.310 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.897244e-01 0.310 0 0
Stimuli-sensing channels R-HSA-2672351 4.912378e-01 0.309 0 0
Alternative complement activation R-HSA-173736 4.930682e-01 0.307 0 0
HCN channels R-HSA-1296061 4.930682e-01 0.307 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.930682e-01 0.307 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 4.930682e-01 0.307 0 0
Nucleotide catabolism defects R-HSA-9735786 4.930682e-01 0.307 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.930682e-01 0.307 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.930682e-01 0.307 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.930682e-01 0.307 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.930682e-01 0.307 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.930682e-01 0.307 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.930682e-01 0.307 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.930682e-01 0.307 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.930682e-01 0.307 0 0
Dopamine receptors R-HSA-390651 4.930682e-01 0.307 0 0
Translation of Structural Proteins R-HSA-9694635 4.942879e-01 0.306 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.062749e-01 0.296 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.062749e-01 0.296 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.062749e-01 0.296 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.062749e-01 0.296 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.106633e-01 0.292 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.106633e-01 0.292 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.106633e-01 0.292 0 0
Maturation of nucleoprotein R-HSA-9694631 5.106633e-01 0.292 0 0
Transmission across Chemical Synapses R-HSA-112315 5.110484e-01 0.292 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.134680e-01 0.289 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.134680e-01 0.289 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.156575e-01 0.288 0 0
Mitochondrial biogenesis R-HSA-1592230 5.172250e-01 0.286 0 0
Leishmania infection R-HSA-9658195 5.286709e-01 0.277 0 0
Parasitic Infection Pathways R-HSA-9824443 5.286709e-01 0.277 0 0
GPVI-mediated activation cascade R-HSA-114604 5.362520e-01 0.271 0 0
Telomere Extension By Telomerase R-HSA-171319 5.366888e-01 0.270 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.366888e-01 0.270 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.366888e-01 0.270 0 0
Protein hydroxylation R-HSA-9629569 5.378707e-01 0.269 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.406479e-01 0.267 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.406479e-01 0.267 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.406479e-01 0.267 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.406479e-01 0.267 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.406479e-01 0.267 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.406479e-01 0.267 0 0
Regulation of IFNG signaling R-HSA-877312 5.406479e-01 0.267 0 0
Interleukin-35 Signalling R-HSA-8984722 5.406479e-01 0.267 0 0
Signaling by LTK R-HSA-9842663 5.406479e-01 0.267 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.406479e-01 0.267 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.406479e-01 0.267 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.473488e-01 0.262 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.473488e-01 0.262 0 0
G2 Phase R-HSA-68911 5.473488e-01 0.262 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.473488e-01 0.262 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 5.473488e-01 0.262 0 0
Defective F9 activation R-HSA-9673221 5.473488e-01 0.262 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.473488e-01 0.262 0 0
Activation of C3 and C5 R-HSA-174577 5.473488e-01 0.262 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.473488e-01 0.262 0 0
Activation of AKT2 R-HSA-165158 5.473488e-01 0.262 0 0
PTK6 Down-Regulation R-HSA-8849472 5.473488e-01 0.262 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.473488e-01 0.262 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.473488e-01 0.262 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.473488e-01 0.262 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.473488e-01 0.262 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.473488e-01 0.262 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.473488e-01 0.262 0 0
Reelin signalling pathway R-HSA-8866376 5.473488e-01 0.262 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.473488e-01 0.262 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.473488e-01 0.262 0 0
Neddylation R-HSA-8951664 5.478903e-01 0.261 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.518593e-01 0.258 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.519465e-01 0.258 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.593375e-01 0.252 0 0
DARPP-32 events R-HSA-180024 5.593375e-01 0.252 0 0
Glucagon-type ligand receptors R-HSA-420092 5.593375e-01 0.252 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.593375e-01 0.252 0 0
FCERI mediated NF-kB activation R-HSA-2871837 5.634491e-01 0.249 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.641904e-01 0.249 0 0
G-protein activation R-HSA-202040 5.641904e-01 0.249 0 0
Lagging Strand Synthesis R-HSA-69186 5.641904e-01 0.249 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.641904e-01 0.249 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.733237e-01 0.242 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.733237e-01 0.242 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.733237e-01 0.242 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.733237e-01 0.242 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.761738e-01 0.239 0 0
Platelet homeostasis R-HSA-418346 5.762584e-01 0.239 0 0
Regulation of insulin secretion R-HSA-422356 5.771632e-01 0.239 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.813725e-01 0.236 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.895730e-01 0.229 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 5.895730e-01 0.229 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.895730e-01 0.229 0 0
Signaling by ALK R-HSA-201556 5.954382e-01 0.225 0 0
RAS processing R-HSA-9648002 5.954382e-01 0.225 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.954382e-01 0.225 0 0
Plus-strand DNA synthesis R-HSA-164525 5.958199e-01 0.225 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.958199e-01 0.225 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.958199e-01 0.225 0 0
Cam-PDE 1 activation R-HSA-111957 5.958199e-01 0.225 0 0
Phosphorylation of Emi1 R-HSA-176417 5.958199e-01 0.225 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.958199e-01 0.225 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.958199e-01 0.225 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.958199e-01 0.225 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.958199e-01 0.225 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.958199e-01 0.225 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.958199e-01 0.225 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.958199e-01 0.225 0 0
Ceramide signalling R-HSA-193681 5.958199e-01 0.225 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.958199e-01 0.225 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.958199e-01 0.225 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.958199e-01 0.225 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.958199e-01 0.225 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.958199e-01 0.225 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.958199e-01 0.225 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.958199e-01 0.225 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.041465e-01 0.219 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.042715e-01 0.219 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.042715e-01 0.219 0 0
cGMP effects R-HSA-418457 6.042715e-01 0.219 0 0
Zinc transporters R-HSA-435354 6.042715e-01 0.219 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.054941e-01 0.218 0 0
Leishmania phagocytosis R-HSA-9664417 6.054941e-01 0.218 0 0
Parasite infection R-HSA-9664407 6.054941e-01 0.218 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.139820e-01 0.212 0 0
LDL clearance R-HSA-8964038 6.139820e-01 0.212 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.142033e-01 0.212 0 0
Generation of second messenger molecules R-HSA-202433 6.142033e-01 0.212 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.324483e-01 0.199 0 0
Erythropoietin activates RAS R-HSA-9027284 6.334867e-01 0.198 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.334867e-01 0.198 0 0
p38MAPK events R-HSA-171007 6.334867e-01 0.198 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.334867e-01 0.198 0 0
Signaling by Activin R-HSA-1502540 6.334867e-01 0.198 0 0
Other semaphorin interactions R-HSA-416700 6.334867e-01 0.198 0 0
Integrin cell surface interactions R-HSA-216083 6.372290e-01 0.196 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.373925e-01 0.196 0 0
Interleukin-20 family signaling R-HSA-8854691 6.373925e-01 0.196 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.391032e-01 0.194 0 0
Signaling by LTK in cancer R-HSA-9842640 6.391032e-01 0.194 0 0
Uncoating of the HIV Virion R-HSA-162585 6.391032e-01 0.194 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 6.391032e-01 0.194 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.391032e-01 0.194 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.391032e-01 0.194 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.391032e-01 0.194 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.391032e-01 0.194 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.391032e-01 0.194 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.391032e-01 0.194 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.391032e-01 0.194 0 0
HDL clearance R-HSA-8964011 6.391032e-01 0.194 0 0
Pyruvate metabolism R-HSA-70268 6.456187e-01 0.190 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.488651e-01 0.188 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.501560e-01 0.187 0 0
HIV Transcription Initiation R-HSA-167161 6.501560e-01 0.187 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.501560e-01 0.187 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.501560e-01 0.187 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.501560e-01 0.187 0 0
Ion channel transport R-HSA-983712 6.541659e-01 0.184 0 0
COPII-mediated vesicle transport R-HSA-204005 6.563950e-01 0.183 0 0
Integration of energy metabolism R-HSA-163685 6.580276e-01 0.182 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.597899e-01 0.181 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.597899e-01 0.181 0 0
RSV-host interactions R-HSA-9833110 6.608807e-01 0.180 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.609855e-01 0.180 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.609855e-01 0.180 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.609855e-01 0.180 0 0
Attachment and Entry R-HSA-9678110 6.609855e-01 0.180 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.609855e-01 0.180 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.609855e-01 0.180 0 0
Activation of SMO R-HSA-5635838 6.609855e-01 0.180 0 0
Killing mechanisms R-HSA-9664420 6.609855e-01 0.180 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.609855e-01 0.180 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.609855e-01 0.180 0 0
Aquaporin-mediated transport R-HSA-445717 6.635496e-01 0.178 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.777536e-01 0.169 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.777536e-01 0.169 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 6.777536e-01 0.169 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.777536e-01 0.169 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.777536e-01 0.169 0 0
Disinhibition of SNARE formation R-HSA-114516 6.777536e-01 0.169 0 0
PTK6 Expression R-HSA-8849473 6.777536e-01 0.169 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.777536e-01 0.169 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.777536e-01 0.169 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.777536e-01 0.169 0 0
Opsins R-HSA-419771 6.777536e-01 0.169 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.777536e-01 0.169 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.777536e-01 0.169 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.777536e-01 0.169 0 0
VLDL clearance R-HSA-8964046 6.777536e-01 0.169 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.777536e-01 0.169 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.777536e-01 0.169 0 0
Netrin mediated repulsion signals R-HSA-418886 6.777536e-01 0.169 0 0
Laminin interactions R-HSA-3000157 6.811688e-01 0.167 0 0
Interleukin-7 signaling R-HSA-1266695 6.811688e-01 0.167 0 0
HDMs demethylate histones R-HSA-3214842 6.811688e-01 0.167 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 6.811688e-01 0.167 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.813577e-01 0.167 0 0
Signal amplification R-HSA-392518 6.813577e-01 0.167 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.813577e-01 0.167 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.813577e-01 0.167 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.839088e-01 0.165 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.868004e-01 0.163 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.868004e-01 0.163 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.868004e-01 0.163 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.868004e-01 0.163 0 0
Coenzyme A biosynthesis R-HSA-196783 6.868004e-01 0.163 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.868004e-01 0.163 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.868004e-01 0.163 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.868004e-01 0.163 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.881389e-01 0.162 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.015313e-01 0.154 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.015313e-01 0.154 0 0
Ion transport by P-type ATPases R-HSA-936837 7.052881e-01 0.152 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.109766e-01 0.148 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.109766e-01 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.109766e-01 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.109766e-01 0.148 0 0
Specification of primordial germ cells R-HSA-9827857 7.109766e-01 0.148 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.122667e-01 0.147 0 0
Minus-strand DNA synthesis R-HSA-164516 7.122667e-01 0.147 0 0
phospho-PLA2 pathway R-HSA-111995 7.122667e-01 0.147 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.122667e-01 0.147 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.122667e-01 0.147 0 0
MET receptor recycling R-HSA-8875656 7.122667e-01 0.147 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.122667e-01 0.147 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.122667e-01 0.147 0 0
Interleukin-9 signaling R-HSA-8985947 7.122667e-01 0.147 0 0
Regulation by c-FLIP R-HSA-3371378 7.122667e-01 0.147 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.122667e-01 0.147 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.122667e-01 0.147 0 0
Interleukin-23 signaling R-HSA-9020933 7.122667e-01 0.147 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.122667e-01 0.147 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.122667e-01 0.147 0 0
Dimerization of procaspase-8 R-HSA-69416 7.122667e-01 0.147 0 0
RSK activation R-HSA-444257 7.122667e-01 0.147 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.153931e-01 0.145 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.206339e-01 0.142 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.208866e-01 0.142 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.208866e-01 0.142 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.208866e-01 0.142 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.208866e-01 0.142 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.210974e-01 0.142 0 0
Iron uptake and transport R-HSA-917937 7.210974e-01 0.142 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.300557e-01 0.137 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.324819e-01 0.135 0 0
PKA activation R-HSA-163615 7.335690e-01 0.135 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.335690e-01 0.135 0 0
Apoptotic factor-mediated response R-HSA-111471 7.335690e-01 0.135 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.335690e-01 0.135 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.335690e-01 0.135 0 0
Mismatch Repair R-HSA-5358508 7.335690e-01 0.135 0 0
Nephron development R-HSA-9831926 7.335690e-01 0.135 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.335690e-01 0.135 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.353890e-01 0.133 0 0
Mitochondrial protein degradation R-HSA-9837999 7.381086e-01 0.132 0 0
Insulin receptor recycling R-HSA-77387 7.392496e-01 0.131 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.392496e-01 0.131 0 0
Pyroptosis R-HSA-5620971 7.392496e-01 0.131 0 0
Neuronal System R-HSA-112316 7.425451e-01 0.129 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.430853e-01 0.129 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.430853e-01 0.129 0 0
CASP8 activity is inhibited R-HSA-5218900 7.430853e-01 0.129 0 0
ALK mutants bind TKIs R-HSA-9700645 7.430853e-01 0.129 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.430853e-01 0.129 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.430853e-01 0.129 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.430853e-01 0.129 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.430853e-01 0.129 0 0
mRNA Editing R-HSA-75072 7.430853e-01 0.129 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.430853e-01 0.129 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.430853e-01 0.129 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.430853e-01 0.129 0 0
WNT mediated activation of DVL R-HSA-201688 7.430853e-01 0.129 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.430853e-01 0.129 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.430853e-01 0.129 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.483709e-01 0.126 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.546394e-01 0.122 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.557597e-01 0.122 0 0
Peroxisomal protein import R-HSA-9033241 7.682999e-01 0.114 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.706045e-01 0.113 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.706045e-01 0.113 0 0
Formation of apoptosome R-HSA-111458 7.706045e-01 0.113 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.706045e-01 0.113 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.706045e-01 0.113 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.706045e-01 0.113 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.706045e-01 0.113 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.706045e-01 0.113 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.706045e-01 0.113 0 0
Peptide hormone biosynthesis R-HSA-209952 7.706045e-01 0.113 0 0
Interleukin-27 signaling R-HSA-9020956 7.706045e-01 0.113 0 0
Maturation of spike protein R-HSA-9683686 7.706045e-01 0.113 0 0
SLC transporter disorders R-HSA-5619102 7.708816e-01 0.113 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.730814e-01 0.112 0 0
DAP12 signaling R-HSA-2424491 7.730814e-01 0.112 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.730814e-01 0.112 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.742545e-01 0.111 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.742545e-01 0.111 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.742545e-01 0.111 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.742545e-01 0.111 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.742545e-01 0.111 0 0
Interleukin-2 family signaling R-HSA-451927 7.775724e-01 0.109 0 0
Diseases of Immune System R-HSA-5260271 7.775724e-01 0.109 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.775724e-01 0.109 0 0
Azathioprine ADME R-HSA-9748787 7.841311e-01 0.106 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.857151e-01 0.105 0 0
Cargo concentration in the ER R-HSA-5694530 7.886009e-01 0.103 0 0
Downstream signal transduction R-HSA-186763 7.886009e-01 0.103 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.924845e-01 0.101 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.924845e-01 0.101 0 0
Signalling to RAS R-HSA-167044 7.924845e-01 0.101 0 0
ERK/MAPK targets R-HSA-198753 7.924845e-01 0.101 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.951775e-01 0.100 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.951775e-01 0.100 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.951775e-01 0.100 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.951775e-01 0.100 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.951775e-01 0.100 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.951775e-01 0.100 0 0
Signaling by APC mutants R-HSA-4839744 7.951775e-01 0.100 0 0
Bicarbonate transporters R-HSA-425381 7.951775e-01 0.100 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.951775e-01 0.100 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.951775e-01 0.100 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.951775e-01 0.100 0 0
Extracellular matrix organization R-HSA-1474244 7.974925e-01 0.098 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.990151e-01 0.097 0 0
Signaling by WNT in cancer R-HSA-4791275 8.032281e-01 0.095 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.032281e-01 0.095 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.040258e-01 0.095 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.065273e-01 0.093 0 0
Ca2+ pathway R-HSA-4086398 8.089476e-01 0.092 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.094007e-01 0.092 0 0
Attachment and Entry R-HSA-9694614 8.094007e-01 0.092 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.094007e-01 0.092 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.162626e-01 0.088 0 0
G-protein beta:gamma signalling R-HSA-397795 8.169946e-01 0.088 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.171195e-01 0.088 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.171195e-01 0.088 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.171195e-01 0.088 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.171195e-01 0.088 0 0
ERKs are inactivated R-HSA-202670 8.171195e-01 0.088 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.171195e-01 0.088 0 0
Signaling by AXIN mutants R-HSA-4839735 8.171195e-01 0.088 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.171195e-01 0.088 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.171195e-01 0.088 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.171195e-01 0.088 0 0
Sodium/Calcium exchangers R-HSA-425561 8.171195e-01 0.088 0 0
Activation of RAC1 R-HSA-428540 8.171195e-01 0.088 0 0
Nucleotide biosynthesis R-HSA-8956320 8.187570e-01 0.087 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.250756e-01 0.084 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.250756e-01 0.084 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.250756e-01 0.084 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.250756e-01 0.084 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.299335e-01 0.081 0 0
Post-translational protein modification R-HSA-597592 8.344531e-01 0.079 0 0
Interleukin-15 signaling R-HSA-8983432 8.367120e-01 0.077 0 0
Polymerase switching R-HSA-69091 8.367120e-01 0.077 0 0
Leading Strand Synthesis R-HSA-69109 8.367120e-01 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.367120e-01 0.077 0 0
Repression of WNT target genes R-HSA-4641265 8.367120e-01 0.077 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.367120e-01 0.077 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.367120e-01 0.077 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.367120e-01 0.077 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.367120e-01 0.077 0 0
OAS antiviral response R-HSA-8983711 8.367120e-01 0.077 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.395808e-01 0.076 0 0
Carnitine shuttle R-HSA-200425 8.395808e-01 0.076 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.420788e-01 0.075 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.420788e-01 0.075 0 0
Cardiac conduction R-HSA-5576891 8.471514e-01 0.072 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.490374e-01 0.071 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.529869e-01 0.069 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.529869e-01 0.069 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.529869e-01 0.069 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.542066e-01 0.068 0 0
Processing of SMDT1 R-HSA-8949664 8.542066e-01 0.068 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.542066e-01 0.068 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.542066e-01 0.068 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.542066e-01 0.068 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.542066e-01 0.068 0 0
Interleukin-6 signaling R-HSA-1059683 8.542066e-01 0.068 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.542066e-01 0.068 0 0
Diseases of DNA repair R-HSA-9675135 8.590616e-01 0.066 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.641278e-01 0.063 0 0
RNA Polymerase III Transcription R-HSA-74158 8.641278e-01 0.063 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.641278e-01 0.063 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.641278e-01 0.063 0 0
Glycosphingolipid transport R-HSA-9845576 8.641278e-01 0.063 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.641278e-01 0.063 0 0
G protein gated Potassium channels R-HSA-1296059 8.653630e-01 0.063 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.653630e-01 0.063 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.653630e-01 0.063 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.653630e-01 0.063 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.653630e-01 0.063 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.653630e-01 0.063 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.653630e-01 0.063 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.663928e-01 0.062 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.683293e-01 0.061 0 0
Removal of the Flap Intermediate R-HSA-69166 8.698277e-01 0.061 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.698277e-01 0.061 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.698277e-01 0.061 0 0
Hydrolysis of LPC R-HSA-1483115 8.698277e-01 0.061 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.698277e-01 0.061 0 0
Physiological factors R-HSA-5578768 8.698277e-01 0.061 0 0
Prolactin receptor signaling R-HSA-1170546 8.698277e-01 0.061 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.698277e-01 0.061 0 0
Malate-aspartate shuttle R-HSA-9856872 8.698277e-01 0.061 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.698277e-01 0.061 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.698277e-01 0.061 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.767758e-01 0.057 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.834205e-01 0.054 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.837760e-01 0.054 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.837760e-01 0.054 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.837760e-01 0.054 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.837760e-01 0.054 0 0
Protein repair R-HSA-5676934 8.837760e-01 0.054 0 0
DNA Damage Reversal R-HSA-73942 8.837760e-01 0.054 0 0
Insulin processing R-HSA-264876 8.872896e-01 0.052 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.872896e-01 0.052 0 0
Metabolism of proteins R-HSA-392499 8.889003e-01 0.051 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.895275e-01 0.051 0 0
Pentose phosphate pathway R-HSA-71336 8.921192e-01 0.050 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.933605e-01 0.049 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.939736e-01 0.049 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.948352e-01 0.048 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.962303e-01 0.048 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.962303e-01 0.048 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.962303e-01 0.048 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.962303e-01 0.048 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.962303e-01 0.048 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.962303e-01 0.048 0 0
Differentiation of T cells R-HSA-9945266 8.962303e-01 0.048 0 0
Virus Assembly and Release R-HSA-168268 8.962303e-01 0.048 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.964767e-01 0.047 0 0
Signaling by PDGF R-HSA-186797 8.964767e-01 0.047 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.002310e-01 0.046 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.002310e-01 0.046 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.052341e-01 0.043 0 0
Signaling by Erythropoietin R-HSA-9006335 9.058635e-01 0.043 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.058635e-01 0.043 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.058635e-01 0.043 0 0
Fibronectin matrix formation R-HSA-1566977 9.073508e-01 0.042 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.073508e-01 0.042 0 0
Passive transport by Aquaporins R-HSA-432047 9.073508e-01 0.042 0 0
Galactose catabolism R-HSA-70370 9.073508e-01 0.042 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.073508e-01 0.042 0 0
Maturation of spike protein R-HSA-9694548 9.077885e-01 0.042 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.116911e-01 0.040 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.140381e-01 0.039 0 0
Intra-Golgi traffic R-HSA-6811438 9.148231e-01 0.039 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.160389e-01 0.038 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.172801e-01 0.037 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.172801e-01 0.037 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.172801e-01 0.037 0 0
Choline catabolism R-HSA-6798163 9.172801e-01 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.172801e-01 0.037 0 0
Activation of GABAB receptors R-HSA-991365 9.213655e-01 0.036 0 0
GABA B receptor activation R-HSA-977444 9.213655e-01 0.036 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.215424e-01 0.035 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.215424e-01 0.035 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.261458e-01 0.033 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.261458e-01 0.033 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.261458e-01 0.033 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.284262e-01 0.032 0 0
DAP12 interactions R-HSA-2172127 9.330901e-01 0.030 0 0
Surfactant metabolism R-HSA-5683826 9.330901e-01 0.030 0 0
Specification of the neural plate border R-HSA-9834899 9.340617e-01 0.030 0 0
Diseases of hemostasis R-HSA-9671793 9.340617e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.340617e-01 0.030 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.340617e-01 0.030 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.347363e-01 0.029 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.347363e-01 0.029 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.347363e-01 0.029 0 0
Cardiogenesis R-HSA-9733709 9.347363e-01 0.029 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.401101e-01 0.027 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.405164e-01 0.027 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.405164e-01 0.027 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.405164e-01 0.027 0 0
Heme degradation R-HSA-189483 9.405164e-01 0.027 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.411296e-01 0.026 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.411296e-01 0.026 0 0
Creatine metabolism R-HSA-71288 9.411296e-01 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.411296e-01 0.026 0 0
Adipogenesis R-HSA-9843745 9.428090e-01 0.026 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.431836e-01 0.025 0 0
ECM proteoglycans R-HSA-3000178 9.435218e-01 0.025 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.444288e-01 0.025 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.458078e-01 0.024 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.474403e-01 0.023 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.474403e-01 0.023 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.474403e-01 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.474403e-01 0.023 0 0
Synthesis of PC R-HSA-1483191 9.476826e-01 0.023 0 0
tRNA Aminoacylation R-HSA-379724 9.484611e-01 0.023 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.486062e-01 0.023 0 0
G alpha (i) signalling events R-HSA-418594 9.490414e-01 0.023 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.506487e-01 0.022 0 0
Metal ion SLC transporters R-HSA-425410 9.518479e-01 0.021 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.522233e-01 0.021 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.530748e-01 0.021 0 0
Androgen biosynthesis R-HSA-193048 9.530748e-01 0.021 0 0
Serine metabolism R-HSA-977347 9.530748e-01 0.021 0 0
Glutathione synthesis and recycling R-HSA-174403 9.530748e-01 0.021 0 0
Glucocorticoid biosynthesis R-HSA-194002 9.530748e-01 0.021 0 0
Signaling by FGFR in disease R-HSA-1226099 9.542559e-01 0.020 0 0
Triglyceride catabolism R-HSA-163560 9.550749e-01 0.020 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.557019e-01 0.020 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.557313e-01 0.020 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.581056e-01 0.019 0 0
Free fatty acid receptors R-HSA-444209 9.581056e-01 0.019 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.581056e-01 0.019 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.590001e-01 0.018 0 0
Voltage gated Potassium channels R-HSA-1296072 9.591196e-01 0.018 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.591196e-01 0.018 0 0
PI3K Cascade R-HSA-109704 9.592655e-01 0.018 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.592655e-01 0.018 0 0
IGF1R signaling cascade R-HSA-2428924 9.620444e-01 0.017 0 0
The phototransduction cascade R-HSA-2514856 9.625587e-01 0.017 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.625973e-01 0.017 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.625973e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.625973e-01 0.017 0 0
Formation of the ureteric bud R-HSA-9830674 9.625973e-01 0.017 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.625973e-01 0.017 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.628137e-01 0.016 0 0
Elastic fibre formation R-HSA-1566948 9.628137e-01 0.016 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.628137e-01 0.016 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.648777e-01 0.016 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.656000e-01 0.015 0 0
G alpha (s) signalling events R-HSA-418555 9.661175e-01 0.015 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.661859e-01 0.015 0 0
Complex III assembly R-HSA-9865881 9.666077e-01 0.015 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.666077e-01 0.015 0 0
Interleukin-6 family signaling R-HSA-6783589 9.666077e-01 0.015 0 0
Neurotransmitter release cycle R-HSA-112310 9.672610e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.675132e-01 0.014 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.680880e-01 0.014 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.684072e-01 0.014 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.692628e-01 0.014 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.693249e-01 0.014 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.694183e-01 0.013 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.694183e-01 0.013 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.699633e-01 0.013 0 0
Kidney development R-HSA-9830369 9.699633e-01 0.013 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.701883e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.701883e-01 0.013 0 0
Formation of the nephric duct R-HSA-9830364 9.701883e-01 0.013 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.709011e-01 0.013 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.733851e-01 0.012 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.733851e-01 0.012 0 0
Urea cycle R-HSA-70635 9.733851e-01 0.012 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.733851e-01 0.012 0 0
Sphingolipid catabolism R-HSA-9845614 9.733851e-01 0.012 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.733851e-01 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.733851e-01 0.012 0 0
Signaling by Insulin receptor R-HSA-74752 9.734086e-01 0.012 0 0
Formation of the cornified envelope R-HSA-6809371 9.735113e-01 0.012 0 0
PPARA activates gene expression R-HSA-1989781 9.743782e-01 0.011 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.746268e-01 0.011 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.752085e-01 0.011 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.762393e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.762393e-01 0.010 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.762393e-01 0.010 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.769575e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.770826e-01 0.010 0 0
IRS-mediated signalling R-HSA-112399 9.776117e-01 0.010 0 0
Dectin-2 family R-HSA-5621480 9.776117e-01 0.010 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.779828e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.787875e-01 0.009 0 0
Interferon gamma signaling R-HSA-877300 9.795256e-01 0.009 0 0
Peptide hormone metabolism R-HSA-2980736 9.805170e-01 0.009 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.811944e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.813372e-01 0.008 0 0
GABA receptor activation R-HSA-977443 9.827735e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.830938e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.830938e-01 0.007 0 0
Collagen degradation R-HSA-1442490 9.842253e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.850305e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.865263e-01 0.006 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.865709e-01 0.006 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.870740e-01 0.006 0 0
Insulin receptor signalling cascade R-HSA-74751 9.879101e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.879717e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.879717e-01 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.892622e-01 0.005 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.894449e-01 0.005 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.894513e-01 0.005 0 0
eNOS activation R-HSA-203615 9.904142e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.904142e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.904142e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.904142e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.904370e-01 0.004 0 0
FCGR activation R-HSA-2029481 9.905405e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.912575e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.914428e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.914428e-01 0.004 0 0
Peptide ligand-binding receptors R-HSA-375276 9.921072e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.931807e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.931807e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.931807e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.931807e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.935706e-01 0.003 0 0
Purine salvage R-HSA-74217 9.939125e-01 0.003 0 0
Biofilm formation R-HSA-9931953 9.939125e-01 0.003 0 0
Purine catabolism R-HSA-74259 9.941286e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.941908e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.947347e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.951491e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.951491e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.956913e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.961033e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.961033e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.961346e-01 0.002 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.963682e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.964766e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.966210e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.968785e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.972506e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.972506e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.973979e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.975458e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.976002e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.980811e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.982669e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.982941e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.987242e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.987242e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.987587e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.987587e-01 0.001 0 0
PI Metabolism R-HSA-1483255 9.987967e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.988832e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.989606e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.990620e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.991173e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.993786e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.994091e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995390e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.995537e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996017e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996827e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997215e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997987e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.998185e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998203e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.998204e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998569e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998723e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999036e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999092e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999190e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999468e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999486e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999541e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999676e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999750e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999770e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999776e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999827e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999858e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999882e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999931e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999931e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999943e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999963e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999976e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999977e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999977e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999981e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999986e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999989e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999995e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways