PKG1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A6ND36 S610 Sugiyama FAM83G PAWS1 LSDQDSHSGSSGRGPGPRRPsVAssVsEEyFEVREHSVPLR
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O00571 S83 Sugiyama DDX3X DBX DDX3 sKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRsD
O14545 T323 Sugiyama TRAFD1 FLN29 ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O14618 S267 Sugiyama CCS DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15085 T1292 Sugiyama ARHGEF11 KIAA0380 GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O15156 S342 Sugiyama ZBTB7B ZBTB15 ZFP67 ZNF857B HQDNLAPGLDSQDKLVRKRRsQMPQECPVCHKIIHGAGKLP
O43768 S109 PSP ENSA KNLVtGDHIPTPQDLPQRKssLVtsKLAGGQVE________
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S137 Sugiyama EIF5B IF2 KIAA0741 EDKDsKSKKTAKPKVEMysGsDDDDDFNKLPKKAKGKAQKS
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S214 Sugiyama EIF5B IF2 KIAA0741 LQsRKGQKKNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAE
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O76074 S102 ELM|iPTMNet|EPSD|PSP PDE5A PDE5 PLQQsPRADNSAPGTPTRKIsAsEFDRPLRPIVVKDSEGTV
O94761 S27 Sugiyama RECQL4 RECQ4 VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT
O94763 S372 Sugiyama URI1 C19orf2 NNX3 PPP1R19 RMP URI KNTTLKFSEKKEEAKRKRKNstGsGHsAQELPTIRTPADIY
O94915 S1957 Sugiyama FRYL AF4P12 KIAA0826 ARsNsLRLsLIGDRRGDRRRsNtLDIMDGRINHsssLARtR
O96001 T119 SIGNOR|iPTMNet|EPSD PPP1R17 C7orf16 GSBS KMIPVLHNTDLEQKKPRRKDtPALHMSPFAAGVTLLRDERP
O96001 T68 SIGNOR|iPTMNet|EPSD PPP1R17 C7orf16 GSBS KNVQATLNVESDQKKPRRKDtPALHIPPFIPGVFSEHLIKR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S15 PSP HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S78 SIGNOR|PSP HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 SIGNOR|PSP|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 T143 SIGNOR|EPSD|PSP HSPB1 HSP27 HSP28 KHEERQDEHGyIsRCFTRKYtLPPGVDPTQVSSsLsPEGtL
P05204 S29 ELM HMGN2 HMG17 DAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAPAKKG
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10644 S101 SIGNOR|EPSD|PSP PRKAR1A PKR1 PRKAR1 TSE1 EIsPPPPNPVVKGRRRRGAIsAEVYTEEDAASYVRKVIPKD
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11831 T159 SIGNOR|EPSD|PSP SRF KTRGRVKIKMEFIDNKLRRYttFsKRKTGIMKKAYELSTLT
P13569 S660 SIGNOR|ELM|iPTMNet|EPSD CFTR ABCC7 FsSKLMGCDSFDQFSAERRNsILTETLHRFsLEGDAPVSWT
P13569 S700 SIGNOR|ELM|iPTMNet|EPSD CFTR ABCC7 TEtKKQsFKQTGEFGEKRKNsILNPINsIRKFsIVQKTPLQ
P13569 S737 ELM|iPTMNet|EPSD CFTR ABCC7 TPLQMNGIEEDSDEPLERRLsLVPDSEQGEAILPRIsVIST
P13569 S768 ELM|iPTMNet|EPSD CFTR ABCC7 ILPRIsVISTGPTLQARRRQsVLNLMTHSVNQGQNIHRKTT
P13569 S795 SIGNOR|ELM|iPTMNet|EPSD CFTR ABCC7 HSVNQGQNIHRKTTAsTRKVsLAPQANLTELDIYsRRLsQE
P13569 S813 SIGNOR|ELM|iPTMNet|EPSD CFTR ABCC7 KVsLAPQANLTELDIYsRRLsQEtGLEISEEINEEDLKECF
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P16220 S119 SIGNOR CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16333 S85 Sugiyama NCK1 NCK ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16949 S63 PSP STMN1 C1orf215 LAP18 OP18 KDLsLEEIQKKLEAAEERRKsHEAEVLKQLAEKREHEKEVL
P17812 S574 Sugiyama CTPS1 CTPS YLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD___
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19429 S23 SIGNOR TNNI3 TNNC1 DGSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsA
P19429 S24 SIGNOR TNNI3 TNNC1 GSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsAs
P21731 S331 PSP TBXA2R FRRAVLRRLQPRLsTRPRsLsLQPQLtQRSGLQ________
P21817 S2843 SIGNOR|iPTMNet|EPSD RYR1 RYDR IEKAREGEEEKTEKKKTRKIsQsAQtyDPREGYNPQPPDLS
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P24046 S443 SIGNOR GABRR1 MMVQLTLAsERssPQRKsQRssYVsMRIDTHAIDKYSRIIF
P24046 S444 SIGNOR|iPTMNet|EPSD GABRR1 MVQLTLAsERssPQRKsQRssYVsMRIDTHAIDKYSRIIFP
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29401 S104 Sugiyama TKT AVWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGs
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30520 S451 Sugiyama ADSS2 ADSS FIEDELQIPVKWIGVGKsREsMIQLF_______________
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31645 T276 SIGNOR|EPSD|PSP SLC6A4 HTT SERT ALCIMLIFTVIYFSIWKGVKtsGKVVWVTATFPYIILSVLL
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35367 S396 ELM|EPSD|PSP HRH1 LRsGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQ
P35367 S398 SIGNOR|ELM|EPSD|PSP HRH1 sGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQLG
P35520 S227 EPSD|PSP CBS AWRLKNEIPNSHILDQYRNAsNPLAHYDTTADEILQQCDGK
P35520 S525 EPSD|PSP CBS MDHFALVVHEQIQYHSTGKSsQRQMVFGVVTAIDLLNFVAA
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P41220 S46 SIGNOR|ELM|iPTMNet|EPSD|PSP RGS2 G0S8 GIG31 SEEKREKMKRTLLKDWKTRLsYFLQNSSTPGKPKTGKKsKQ
P41220 S64 SIGNOR|ELM|iPTMNet|EPSD|PSP RGS2 G0S8 GIG31 RLsYFLQNSSTPGKPKTGKKsKQQAFIKPSPEEAQLWSEAF
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43694 S262 EPSD|PSP GATA4 GLYHKMNGINRPLIKPQRRLsASRRVGLSCANCQTTTTTLW
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48995 S206 PSP TRPC1 TRP1 PKPHAVGCECTLCSAKNKKDsLRHSRFRLDIYRCLASPALI
P48995 T347 PSP TRPC1 TRP1 CQQFLNTVWFGQMSGYRRKPtCKKIMTVLTVGIFWPVLSLC
P49327 S1997 Sugiyama FASN FAS DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49815 S1364 PSP TSC2 TSC4 EKsLHAEELVGRGIPIERVVssEGGRPsVDLsFQPsQPLsK
P50552 S157 SIGNOR|ELM|iPTMNet|EPSD|PSP VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50552 S239 SIGNOR|ELM|iPTMNet|EPSD|PSP VASP GGAGAPGLAAAIAGAKLRKVsKQEEAsGGPTAPKAESGRSG
P50552 T278 SIGNOR|ELM|iPTMNet|EPSD|PSP VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P52943 S104 SIGNOR|ELM|iPTMNet|EPSD CRIP2 CRP2 GPQVTGPIEVPAARAEERKAsGPPKGPsRAssVttFtGEPN
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P56211 S104 PSP ARPP19 KTEVTGDHIPTPQDLPQRKPsLVAsKLAG____________
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61224 S179 ELM|EPSD|PSP RAP1B OK/SW-cl.11 yDLVRQINRKTPVPGKARKKssCQLL_______________
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61586 S188 EPSD|PSP RHOA ARH12 ARHA RHO12 REVFEMAtRAALQARRGKKKsGCLVL_______________
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78347 S392 EPSD GTF2I BAP135 WBSCR6 KYAQAIKAKGPVTIPYPLFQsHVEDLyVEGLPEGIPFRRPs
P78347 S412 SIGNOR|iPTMNet|EPSD|PSP GTF2I BAP135 WBSCR6 sHVEDLyVEGLPEGIPFRRPstYGIPRLERILLAKERIRFV
P78347 S764 EPSD GTF2I BAP135 WBSCR6 KCGEALGLKQAVKVPFALFEsFPEDFYVEGLPEGVPFRRPs
P78347 S784 SIGNOR|iPTMNet|EPSD|PSP GTF2I BAP135 WBSCR6 sFPEDFYVEGLPEGVPFRRPstFGIPRLEKILRNKAKIKFI
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01970 S1105 SIGNOR|iPTMNet|EPSD PLCB3 EMNEREKKELQKILDRKRHNsIsEAKMRDKHKKEAELTEIN
Q01970 S26 SIGNOR|iPTMNet|EPSD PLCB3 PGVHALQLEPPTVVETLRRGsKFIKWDEETSSRNLVTLRVD
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02952 S627 Sugiyama AKAP12 AKAP250 VtPWAsFKKMVtPKKRVRRPsEsDKEDELDKVKsAtLsstE
Q03393 S19 SIGNOR|EPSD|PSP PTS __MSTEGGGRRCQAQVSRRIsFsASHRLYSKFLSDEENLKL
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q05469 S853 EPSD|PSP LIPE ELSGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKN
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q08211 S449 Sugiyama DHX9 DDX9 LKP NDH2 FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12802 S1559 Sugiyama AKAP13 BRX HT31 LBC DsITEVPANCSVLRSSMRSLsPFRRHsWGPGKNAASDAEMN
Q12965 T935 Sugiyama MYO1E MYO1C VLQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAA
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13112 S410 Sugiyama CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13153 S21 PSP PAK1 MsNNGLDIQDKPPAPPMRNTsTMIGAGSKDAGTLNHGSKPL
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13507 S336 PSP TRPC3 TRP3 NELAKLANIEKEFKNDYRKLsMQCKDFVVGVLDLCRDSEEV
Q13573 S83 Sugiyama SNW1 SKIIP SKIP AFPEIHVAQYPLDMGRKKKMsNALAIQVDsEGKIKYDAIAR
Q13976 S273 Sugiyama PRKG1 PRKG1B PRKGR1A PRKGR1B ARGDTFFIISKGTVNVtREDsPsEDPVFLRTLGKGDWFGEK
Q13976 S65 SIGNOR|EPSD|PSP PRKG1 PRKG1B PRKGR1A PRKGR1B SVLPVPsTHIGPRTtRAQGIsAEPQTYRsFHDLRQAFRKFt
Q13976 S73 Sugiyama PRKG1 PRKG1B PRKGR1A PRKGR1B HIGPRTtRAQGIsAEPQTYRsFHDLRQAFRKFtKSERSKDL
Q13976 T269 Sugiyama PRKG1 PRKG1B PRKGR1A PRKGR1B IRQGARGDTFFIISKGTVNVtREDsPsEDPVFLRTLGKGDW
Q13976 T59 Sugiyama PRKG1 PRKG1B PRKGR1A PRKGR1B KLHKCQSVLPVPsTHIGPRTtRAQGIsAEPQTYRsFHDLRQ
Q14135 S59 Sugiyama VGLL4 KIAA0121 SALsSHRTGPPPIsPSKRKFsMEPGDEDLDCDNDHVSKMSR
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14643 S1764 SIGNOR|EPSD ITPR1 INSP3R1 LRQVLVNRYYGNVRPSGRREsLtsFGNGPLSAGGPGKPGGG
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14847 S146 SIGNOR|ELM|EPSD|PSP|Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q14980 S1991 Sugiyama NUMA1 NMP22 NUMA QPIQIAEGTGITTRQQRKRVsLEPHQGPGtPEsKKATSCFP
Q15052 S684 EPSD|PSP ARHGEF6 COOL2 KIAA0006 PIXA EAYCTSANFQQGHGsstRKDsIPQVLLPEEEKLIIEETRsN
Q15637 S20 SIGNOR|ELM|iPTMNet|EPSD SF1 ZFM1 ZNF162 _MAtGANAtPLDFPsKKRKRsRWNQDtMEQKTVIPGMPTVI
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5UIP0 S1542 Sugiyama RIF1 VDKssEKLVRGRTRYQTRRAsQGLLssIENsEsDssEAKEE
Q5VSY0 S106 SIGNOR|iPTMNet|EPSD GKAP1 GKAP42 FKSG21 SHAVCNAQHDLPLSNPVQKDsREENWQEWRQRDEQLTSEMF
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q684P5 S7 EPSD|PSP RAP1GAP2 GARNL4 KIAA1039 RAP1GA2 ______________MFGRKRsVsFGGFGWIDKTMLASLKVK
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6GYQ0 T1002 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q6ZVN8 T290 Sugiyama HJV HFE2 RGMC PGNHVEIQAAYIGTTIIIRQtAGQLSFSIKVAEDVAMAFSA
Q76M96 S409 EPSD|PSP CCDC80 DRO1 URB HBE245 TPSPSHRPPTTTEVITARRPsVSENLYPPSRKDQHRERPQT
Q76M96 S434 EPSD|PSP CCDC80 DRO1 URB HBE245 LYPPSRKDQHRERPQTTRRPsKATSLESFTNAPPTTISEPS
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86UU1 T580 Sugiyama PHLDB1 KIAA0638 LL5A DLNB07 RKLssGDLRVPVTRERKNsItEIsDNEDDLLEYHRRQRQER
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWW6 S240 Sugiyama ARHGAP12 SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6 T231 Sugiyama ARHGAP12 QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N142 S452 Sugiyama ADSS1 ADSSL1 FVENHVGVAVKWVGVGKsREsMIQLF_______________
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N3D4 S1257 Sugiyama EHBP1L1 EGLVNGAGAPGGGGVRLRRPsVNGEPGSVPPPRAHGsFsHV
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ5 S607 Sugiyama COLGALT1 GLT25D1 PSEC0241 DRAKSQKMREQQALSREAKNsDVLQsPLDsAARDEL_____
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TEW0 Y719 Sugiyama PARD3 PAR3 PAR3A PELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIM
Q8WZ42 S11878 PSP TTN KVRKLLPERKPEPKEEVVLKsVLRKRPEEEEPKVEPKKLEK
Q8WZ42 S4010 PSP TTN SANPLENAGQDSAVRIEEGKsLRFPLALEEKQVLLKEEHSD
Q8WZ42 S4092 PSP TTN EEQRLNLKIQICRALQAAVAsEQPGLFsEWLRNIEKVEVEA
Q8WZ42 S4099 PSP TTN KIQICRALQAAVAsEQPGLFsEWLRNIEKVEVEAVNITQEP
Q8WZ42 S4185 EPSD|PSP TTN YEEIDILTAEGPRIQQGAKTsLQEEMDSFSGSQKVEPITEP
Q96A00 T38 EPSD|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96D15 S117 Sugiyama RCN3 UNQ239/PRO272 VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96D31 S34 EPSD|PSP ORAI1 CRACM1 TMEM142A PELPPSGGSTTSGsRRsRRRsGDGEPPGAPPPPPSAVTYPD
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99848 T261 Sugiyama EBNA1BP2 EBP2 RRYKNQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGL
Q9BTC0 S1456 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9H814 T151 Sugiyama PHAX RNUXA ATELGILGMEGTIDRsRQsEtyNyLLAKKLRKESQEHTKDL
Q9HCX4 T15 SIGNOR TRPC7 TRP7 ______MLRNSTFKNMQRRHtTLREKGRRQAIRGPAYMFNE
Q9NS28 S216 SIGNOR|EPSD|PSP RGS18 RGS13 DIYLDLMEGRPQRPTNLRRRsRsFTCNEFQDVQSDVAIWL_
Q9NTU7 S74 Sugiyama CBLN4 CBLNL1 UNQ718/PRO1382 GSSSSPLGISVRAANSKVAFsAVRSTNHEPSEMSNKTRIIY
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NYF8 S319 Sugiyama BCLAF1 BTF KIAA0164 RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9P258 S44 Sugiyama RCC2 KIAA1470 TD60 GPRKRGGPAGRKRERPERCssssGGGssGDEDGLELDGAPG
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UH03 S91 SIGNOR|iPTMNet|EPSD SEPTIN3 SEP3 SEPT3 GLGKSTLVNTLFKSQVSRKAsSWNREEKIPKTVEIKAIGHV
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9ULL1 S615 Sugiyama PLEKHG1 KIAA1209 STETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTRELQNSP
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UPT8 S131 Sugiyama ZC3H4 C19orf7 KIAA1064 REKEKRRSKKRRKSKHKRHAsSSDDFsDFsDDsDFsPSEKG
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y210 S322 SIGNOR|EPSD|PSP TRPC6 TRP6 NELAVLANIEKEFKNDYKKLsMQCKDFVVGLLDLCRNTEEV
Q9Y210 T70 SIGNOR|EPSD|PSP TRPC6 TRP6 CYGYYPCFRGSDNRLAHRRQtVLREKGRRLANRGPAYMFSD
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y613 S1131 SIGNOR|ELM|EPSD|PSP FHOD1 FHOS FHOS1 LVQSVTKSSPRALAARERKRsRGNRKsLRRtLKSGLGDDLV
Q9Y6F6 S689 ELM|EPSD IRAG1 IRAG JAW1L MRVI1 PRTARSMSLTLGKNMPRRRVsVAVVPKFNALNLPGQTPSSS
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 7.547892e-10 9.122 0 0
Cell Cycle R-HSA-1640170 2.294767e-09 8.639 0 0
Attenuation phase R-HSA-3371568 7.950219e-09 8.100 0 0
Signal Transduction R-HSA-162582 1.959249e-07 6.708 1 0
HSF1 activation R-HSA-3371511 4.710397e-07 6.327 0 0
Cellular response to heat stress R-HSA-3371556 4.685514e-07 6.329 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.293212e-06 5.888 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.703037e-06 5.769 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.703037e-06 5.769 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.969685e-06 5.706 0 0
G alpha (12/13) signalling events R-HSA-416482 2.202964e-06 5.657 0 0
NRAGE signals death through JNK R-HSA-193648 2.229333e-06 5.652 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.756371e-06 5.560 0 0
Axon guidance R-HSA-422475 3.374177e-06 5.472 0 0
Cell Cycle, Mitotic R-HSA-69278 4.079737e-06 5.389 0 0
Mitotic Prometaphase R-HSA-68877 4.840189e-06 5.315 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.575460e-06 5.121 0 0
Cell Cycle Checkpoints R-HSA-69620 8.468843e-06 5.072 0 0
Nervous system development R-HSA-9675108 8.441152e-06 5.074 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.541292e-06 5.068 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.537558e-05 4.813 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.584625e-05 4.588 0 0
M Phase R-HSA-68886 2.921804e-05 4.534 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.932835e-05 4.533 0 0
Death Receptor Signaling R-HSA-73887 3.159637e-05 4.500 0 0
Separation of Sister Chromatids R-HSA-2467813 5.638380e-05 4.249 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.130623e-05 4.212 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.001536e-05 4.046 0 0
Kinesins R-HSA-983189 1.346920e-04 3.871 0 0
Apoptotic execution phase R-HSA-75153 1.330536e-04 3.876 0 0
Chromatin modifying enzymes R-HSA-3247509 1.531642e-04 3.815 0 0
Activation of RAC1 R-HSA-428540 1.979845e-04 3.703 0 0
Post NMDA receptor activation events R-HSA-438064 2.390986e-04 3.621 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.962020e-04 3.528 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.507746e-04 3.455 0 0
Mitotic Anaphase R-HSA-68882 4.571233e-04 3.340 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.012566e-04 3.300 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.701569e-04 3.244 0 0
Chromatin organization R-HSA-4839726 5.947895e-04 3.226 0 0
Signaling by ROBO receptors R-HSA-376176 6.518853e-04 3.186 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.298914e-04 3.137 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.558376e-04 3.122 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.269251e-03 2.896 0 0
TRP channels R-HSA-3295583 1.270435e-03 2.896 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.256213e-03 2.901 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.319306e-03 2.880 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.329068e-03 2.876 0 0
Meiotic synapsis R-HSA-1221632 1.444410e-03 2.840 0 0
Rap1 signalling R-HSA-392517 1.471230e-03 2.832 0 0
Regulation of TP53 Activity R-HSA-5633007 1.570470e-03 2.804 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.709462e-03 2.767 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.821840e-03 2.739 0 0
Cellular Senescence R-HSA-2559583 2.095939e-03 2.679 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.368993e-03 2.625 0 0
HDMs demethylate histones R-HSA-3214842 3.008796e-03 2.522 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.390707e-03 2.470 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.560593e-03 2.448 0 0
Metalloprotease DUBs R-HSA-5689901 3.803311e-03 2.420 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.240795e-03 2.373 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.698071e-03 2.328 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.756997e-03 2.323 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.979704e-03 2.303 0 0
Nucleosome assembly R-HSA-774815 4.979704e-03 2.303 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.067824e-03 2.295 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.068705e-03 2.217 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.863321e-03 2.232 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.818929e-03 2.235 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.019867e-03 2.220 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.863321e-03 2.232 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.863321e-03 2.232 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.914963e-03 2.228 0 0
Signaling by RAS mutants R-HSA-6802949 5.863321e-03 2.232 0 0
Selective autophagy R-HSA-9663891 5.389568e-03 2.268 0 0
Diseases of programmed cell death R-HSA-9645723 5.389568e-03 2.268 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.914963e-03 2.228 0 0
Cellular responses to stress R-HSA-2262752 5.738312e-03 2.241 0 0
Neurexins and neuroligins R-HSA-6794361 6.577589e-03 2.182 0 0
Muscle contraction R-HSA-397014 6.665398e-03 2.176 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.912620e-03 2.160 0 0
Neurodegenerative Diseases R-HSA-8863678 6.912620e-03 2.160 0 0
Semaphorin interactions R-HSA-373755 6.784638e-03 2.168 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.669529e-03 2.115 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.367763e-03 2.077 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.367763e-03 2.077 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.367763e-03 2.077 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.788995e-03 2.056 0 0
Interleukin-37 signaling R-HSA-9008059 8.788995e-03 2.056 0 0
EPH-Ephrin signaling R-HSA-2682334 9.422029e-03 2.026 0 0
G2/M Transition R-HSA-69275 9.182014e-03 2.037 0 0
Apoptosis R-HSA-109581 9.141307e-03 2.039 0 0
MAPK family signaling cascades R-HSA-5683057 9.516178e-03 2.022 0 0
RMTs methylate histone arginines R-HSA-3214858 9.759186e-03 2.011 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.003150e-02 1.999 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.008254e-02 1.996 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.061289e-02 1.974 0 0
Regulation of PTEN localization R-HSA-8948747 1.070862e-02 1.970 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.173884e-02 1.930 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.318419e-02 1.880 0 0
Meiosis R-HSA-1500620 1.247464e-02 1.904 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.401493e-02 1.853 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.386912e-02 1.858 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.386632e-02 1.858 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.386632e-02 1.858 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.326041e-02 1.877 0 0
Cellular responses to stimuli R-HSA-8953897 1.385192e-02 1.858 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.342788e-02 1.872 0 0
L1CAM interactions R-HSA-373760 1.411992e-02 1.850 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.453403e-02 1.838 0 0
Autophagy R-HSA-9612973 1.499625e-02 1.824 0 0
Recycling pathway of L1 R-HSA-437239 1.511775e-02 1.821 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.533563e-02 1.814 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.684363e-02 1.774 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.684125e-02 1.774 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.724582e-02 1.763 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.724582e-02 1.763 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.759531e-02 1.755 0 0
Macroautophagy R-HSA-1632852 1.850662e-02 1.733 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.881057e-02 1.726 0 0
FOXO-mediated transcription R-HSA-9614085 2.065103e-02 1.685 0 0
Mitotic Prophase R-HSA-68875 1.982577e-02 1.703 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.052402e-02 1.688 0 0
Deubiquitination R-HSA-5688426 1.990519e-02 1.701 0 0
Cardiac conduction R-HSA-5576891 2.076485e-02 1.683 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.162611e-02 1.665 0 0
Long-term potentiation R-HSA-9620244 2.236609e-02 1.650 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.243290e-02 1.649 0 0
Aggrephagy R-HSA-9646399 2.276951e-02 1.643 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.278521e-02 1.642 0 0
Programmed Cell Death R-HSA-5357801 2.282472e-02 1.642 0 0
Ion homeostasis R-HSA-5578775 2.341902e-02 1.630 0 0
Neuronal System R-HSA-112316 2.504813e-02 1.601 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.724831e-02 1.565 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.813722e-02 1.551 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.910785e-02 1.536 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.948735e-02 1.530 0 0
MAP2K and MAPK activation R-HSA-5674135 2.990352e-02 1.524 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.315727e-02 1.479 0 0
Ephrin signaling R-HSA-3928664 3.315727e-02 1.479 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.144721e-02 1.502 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.144721e-02 1.502 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.224486e-02 1.492 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.315727e-02 1.479 0 0
Ub-specific processing proteases R-HSA-5689880 3.303518e-02 1.481 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.315727e-02 1.479 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.431754e-02 1.464 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.459122e-02 1.461 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.469040e-02 1.460 0 0
HATs acetylate histones R-HSA-3214847 3.504259e-02 1.455 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.527915e-02 1.452 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.627030e-02 1.440 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.803293e-02 1.420 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.022662e-02 1.395 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.878122e-02 1.411 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.683281e-02 1.434 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.985426e-02 1.400 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.932723e-02 1.405 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.022662e-02 1.395 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.735812e-02 1.428 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.060304e-02 1.391 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.064193e-02 1.391 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.198693e-02 1.377 0 0
DARPP-32 events R-HSA-180024 4.281662e-02 1.368 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.326672e-02 1.364 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.326672e-02 1.364 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.326672e-02 1.364 0 0
PKR-mediated signaling R-HSA-9833482 4.407247e-02 1.356 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.449500e-02 1.352 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.564211e-02 1.341 0 0
Stimuli-sensing channels R-HSA-2672351 4.683684e-02 1.329 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.754834e-02 1.323 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.794586e-02 1.319 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.318950e-02 1.274 0 0
Centrosome maturation R-HSA-380287 4.875696e-02 1.312 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.875305e-02 1.312 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.259192e-02 1.279 0 0
Interleukin-12 signaling R-HSA-9020591 5.324038e-02 1.274 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.359003e-02 1.271 0 0
FLT3 Signaling R-HSA-9607240 5.359003e-02 1.271 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.450685e-02 1.264 0 0
mRNA 3'-end processing R-HSA-72187 5.489320e-02 1.260 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.559042e-02 1.255 0 0
Trafficking of AMPA receptors R-HSA-399719 5.666257e-02 1.247 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.669441e-02 1.246 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.739180e-02 1.241 0 0
Type I hemidesmosome assembly R-HSA-446107 5.739180e-02 1.241 0 0
Adrenoceptors R-HSA-390696 5.739180e-02 1.241 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.739180e-02 1.241 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.905362e-02 1.229 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.905362e-02 1.229 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.473585e-02 1.189 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.473585e-02 1.189 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.473585e-02 1.189 0 0
RET signaling R-HSA-8853659 5.885933e-02 1.230 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.032465e-02 1.220 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.455688e-02 1.190 0 0
Glycolysis R-HSA-70171 6.156040e-02 1.211 0 0
MHC class II antigen presentation R-HSA-2132295 6.234834e-02 1.205 0 0
NrCAM interactions R-HSA-447038 6.473585e-02 1.189 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.544954e-02 1.184 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.624933e-02 1.179 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.637032e-02 1.178 0 0
MTOR signalling R-HSA-165159 6.716158e-02 1.173 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.368414e-02 1.133 0 0
ALK mutants bind TKIs R-HSA-9700645 7.368414e-02 1.133 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.698080e-02 1.114 0 0
Packaging Of Telomere Ends R-HSA-171306 7.063894e-02 1.151 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.311331e-02 1.136 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.311331e-02 1.136 0 0
HDACs deacetylate histones R-HSA-3214815 7.373132e-02 1.132 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.268988e-02 1.139 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.543139e-02 1.122 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.434813e-02 1.129 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.698080e-02 1.114 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.368414e-02 1.133 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.078383e-02 1.150 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.389524e-02 1.131 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.389524e-02 1.131 0 0
Calcineurin activates NFAT R-HSA-2025928 7.368414e-02 1.133 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.111139e-02 1.148 0 0
Signaling by NTRKs R-HSA-166520 7.318113e-02 1.136 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.368414e-02 1.133 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.698080e-02 1.114 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.311331e-02 1.136 0 0
Reproduction R-HSA-1474165 7.263539e-02 1.139 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.368414e-02 1.133 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.772224e-02 1.109 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.053034e-02 1.094 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.101980e-02 1.091 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.121622e-02 1.090 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.233743e-02 1.084 0 0
Netrin-1 signaling R-HSA-373752 8.277304e-02 1.082 0 0
Chromosome Maintenance R-HSA-73886 8.290961e-02 1.081 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.296385e-02 1.081 0 0
Polo-like kinase mediated events R-HSA-156711 8.328638e-02 1.079 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.328638e-02 1.079 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.328638e-02 1.079 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.221049e-01 0.913 0 0
KIT mutants bind TKIs R-HSA-9669921 1.221049e-01 0.913 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.221049e-01 0.913 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.221049e-01 0.913 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.221049e-01 0.913 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.221049e-01 0.913 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.221049e-01 0.913 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.221049e-01 0.913 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.221049e-01 0.913 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.221049e-01 0.913 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.221049e-01 0.913 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.221049e-01 0.913 0 0
Regulation of TP53 Expression R-HSA-6804754 9.658769e-02 1.015 0 0
Potassium transport channels R-HSA-1296067 9.658769e-02 1.015 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.293065e-01 0.640 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.293065e-01 0.640 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.293065e-01 0.640 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.293065e-01 0.640 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.293065e-01 0.640 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 2.293065e-01 0.640 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.293065e-01 0.640 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.293065e-01 0.640 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.293065e-01 0.640 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.293065e-01 0.640 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.293065e-01 0.640 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.293065e-01 0.640 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.293065e-01 0.640 0 0
Axonal growth stimulation R-HSA-209563 1.389865e-01 0.857 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.389865e-01 0.857 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 8.810166e-02 1.055 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.810166e-02 1.055 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 8.810166e-02 1.055 0 0
Signaling by MAPK mutants R-HSA-9652817 8.810166e-02 1.055 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.144527e-01 0.941 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.144527e-01 0.941 0 0
CREB phosphorylation R-HSA-199920 1.144527e-01 0.941 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.845038e-01 0.734 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.845038e-01 0.734 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.845038e-01 0.734 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.845038e-01 0.734 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.845038e-01 0.734 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.234229e-01 0.490 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.234229e-01 0.490 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.234229e-01 0.490 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.234229e-01 0.490 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.234229e-01 0.490 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.234229e-01 0.490 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.234229e-01 0.490 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.234229e-01 0.490 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.234229e-01 0.490 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.234229e-01 0.490 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.234229e-01 0.490 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.234229e-01 0.490 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.234229e-01 0.490 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.234229e-01 0.490 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.234229e-01 0.490 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.234229e-01 0.490 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.234229e-01 0.490 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.234229e-01 0.490 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.234229e-01 0.490 0 0
Intestinal infectious diseases R-HSA-8942233 3.234229e-01 0.490 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.234229e-01 0.490 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.205384e-02 1.036 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.433541e-01 0.844 0 0
SOS-mediated signalling R-HSA-112412 1.433541e-01 0.844 0 0
IRS activation R-HSA-74713 2.317465e-01 0.635 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.317465e-01 0.635 0 0
Regulation of KIT signaling R-HSA-1433559 8.887018e-02 1.051 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.887018e-02 1.051 0 0
cGMP effects R-HSA-418457 8.887018e-02 1.051 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.743541e-01 0.759 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.344747e-01 0.871 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.344747e-01 0.871 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.344747e-01 0.871 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.052912e-01 0.978 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.052912e-01 0.978 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.230884e-01 0.910 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.581803e-01 0.801 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.581803e-01 0.801 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.581803e-01 0.801 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.581803e-01 0.801 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.581803e-01 0.801 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.070045e-01 0.684 0 0
ARMS-mediated activation R-HSA-170984 2.070045e-01 0.684 0 0
Lipophagy R-HSA-9613354 2.070045e-01 0.684 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.796155e-01 0.553 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.796155e-01 0.553 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.796155e-01 0.553 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.796155e-01 0.553 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.796155e-01 0.553 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.060508e-01 0.391 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.060508e-01 0.391 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.060508e-01 0.391 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.060508e-01 0.391 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.060508e-01 0.391 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.060508e-01 0.391 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.060508e-01 0.391 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.060508e-01 0.391 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.060508e-01 0.391 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.060508e-01 0.391 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.060508e-01 0.391 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.060508e-01 0.391 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.060508e-01 0.391 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.060508e-01 0.391 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.060508e-01 0.391 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.060508e-01 0.391 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.832881e-01 0.737 0 0
Formation of axial mesoderm R-HSA-9796292 1.832881e-01 0.737 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.009897e-01 0.996 0 0
Formation of apoptosome R-HSA-111458 2.408748e-01 0.618 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.408748e-01 0.618 0 0
PI3K/AKT activation R-HSA-198203 2.408748e-01 0.618 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.408748e-01 0.618 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.408748e-01 0.618 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.272537e-01 0.485 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.272537e-01 0.485 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.272537e-01 0.485 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.272537e-01 0.485 0 0
RAF activation R-HSA-5673000 9.223040e-02 1.035 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.148523e-01 0.940 0 0
Notch-HLH transcription pathway R-HSA-350054 1.621445e-01 0.790 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.755620e-01 0.560 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.755620e-01 0.560 0 0
Signaling by APC mutants R-HSA-4839744 2.755620e-01 0.560 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.755620e-01 0.560 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.755620e-01 0.560 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.755620e-01 0.560 0 0
DCC mediated attractive signaling R-HSA-418885 2.368699e-01 0.625 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.368699e-01 0.625 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.368699e-01 0.625 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.368699e-01 0.625 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.368699e-01 0.625 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.140058e-01 0.943 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.061123e-01 0.686 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.558375e-01 0.807 0 0
DNA methylation R-HSA-5334118 1.762264e-01 0.754 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.762264e-01 0.754 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.762264e-01 0.754 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.292530e-01 0.640 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.292530e-01 0.640 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.292530e-01 0.640 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.292530e-01 0.640 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.292530e-01 0.640 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.649206e-01 0.577 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.106967e-01 0.508 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.106967e-01 0.508 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.106967e-01 0.508 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.106967e-01 0.508 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.740042e-01 0.427 0 0
Netrin mediated repulsion signals R-HSA-418886 3.740042e-01 0.427 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.740042e-01 0.427 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.740042e-01 0.427 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.740042e-01 0.427 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.740042e-01 0.427 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.740042e-01 0.427 0 0
Phenylketonuria R-HSA-2160456 4.785918e-01 0.320 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.785918e-01 0.320 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.785918e-01 0.320 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.785918e-01 0.320 0 0
Invadopodia formation R-HSA-8941237 4.785918e-01 0.320 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.785918e-01 0.320 0 0
Classical Kir channels R-HSA-1296053 4.785918e-01 0.320 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.785918e-01 0.320 0 0
Defective pyroptosis R-HSA-9710421 1.347414e-01 0.870 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.708619e-01 0.767 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.708619e-01 0.767 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.935738e-01 0.713 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.651604e-01 0.782 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.134880e-01 0.945 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.935356e-01 0.532 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.935356e-01 0.532 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.935356e-01 0.532 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.413785e-01 0.617 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.459464e-01 0.461 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.276265e-01 0.894 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.301484e-01 0.638 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.370073e-01 0.863 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.225179e-01 0.491 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.193734e-01 0.377 0 0
Activation of RAS in B cells R-HSA-1169092 4.193734e-01 0.377 0 0
Formation of annular gap junctions R-HSA-196025 4.193734e-01 0.377 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.781808e-01 0.749 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.094845e-01 0.679 0 0
Metabolism of non-coding RNA R-HSA-194441 1.707251e-01 0.768 0 0
snRNP Assembly R-HSA-191859 1.707251e-01 0.768 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.483362e-02 1.023 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.483362e-02 1.023 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.810175e-01 0.419 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.688166e-01 0.571 0 0
Striated Muscle Contraction R-HSA-390522 2.688166e-01 0.571 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.516821e-01 0.454 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.210849e-01 0.655 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.910450e-01 0.536 0 0
Activation of the pre-replicative complex R-HSA-68962 3.294279e-01 0.482 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.294279e-01 0.482 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.156545e-01 0.381 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.630018e-01 0.334 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.630018e-01 0.334 0 0
Gap junction degradation R-HSA-190873 4.630018e-01 0.334 0 0
HCN channels R-HSA-1296061 5.422768e-01 0.266 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.422768e-01 0.266 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.422768e-01 0.266 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.422768e-01 0.266 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.422768e-01 0.266 0 0
Defective MAT1A causes MATD R-HSA-5579024 5.422768e-01 0.266 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.422768e-01 0.266 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.422768e-01 0.266 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.521551e-01 0.453 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.521551e-01 0.453 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.783883e-01 0.422 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.267306e-01 0.644 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.378322e-01 0.624 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.098794e-01 0.387 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.098794e-01 0.387 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.267410e-01 0.644 0 0
Erythropoietin activates RAS R-HSA-9027284 4.496394e-01 0.347 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.496394e-01 0.347 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.978700e-01 0.400 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.978700e-01 0.400 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.386105e-01 0.358 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.046379e-01 0.297 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.046379e-01 0.297 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.983442e-01 0.525 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.921388e-01 0.407 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.291179e-01 0.367 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.291179e-01 0.367 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.291179e-01 0.367 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.940161e-01 0.532 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.873415e-01 0.542 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.873415e-01 0.542 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.813833e-01 0.419 0 0
Phosphorylation of the APC/C R-HSA-176412 4.827896e-01 0.316 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.827896e-01 0.316 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.476370e-01 0.459 0 0
HIV Transcription Elongation R-HSA-167169 4.130786e-01 0.384 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.130786e-01 0.384 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.130786e-01 0.384 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.995759e-01 0.398 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.934863e-01 0.405 0 0
HIV elongation arrest and recovery R-HSA-167287 4.541920e-01 0.343 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.541920e-01 0.343 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.910561e-01 0.536 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.763580e-01 0.559 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.659373e-01 0.332 0 0
Signaling by Erythropoietin R-HSA-9006335 4.789541e-01 0.320 0 0
Late endosomal microautophagy R-HSA-9615710 4.789541e-01 0.320 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.149554e-01 0.288 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.149554e-01 0.288 0 0
Phase 2 - plateau phase R-HSA-5576893 5.149554e-01 0.288 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.441177e-01 0.264 0 0
Viral mRNA Translation R-HSA-192823 4.160374e-01 0.381 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.445721e-01 0.352 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.033258e-01 0.298 0 0
mRNA Splicing R-HSA-72172 3.911907e-01 0.408 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.218397e-01 0.282 0 0
Voltage gated Potassium channels R-HSA-1296072 5.101830e-01 0.292 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.460174e-01 0.263 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.482670e-01 0.261 0 0
Deadenylation of mRNA R-HSA-429947 5.482670e-01 0.261 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.813467e-01 0.236 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.813467e-01 0.236 0 0
ERKs are inactivated R-HSA-202670 5.813467e-01 0.236 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.357936e-01 0.271 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.394015e-01 0.268 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.758834e-01 0.240 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.744747e-01 0.241 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.744747e-01 0.241 0 0
PPARA activates gene expression R-HSA-1989781 5.732214e-01 0.242 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.768450e-01 0.239 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.805931e-01 0.236 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.490956e-01 0.604 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.873415e-01 0.542 0 0
Integrin signaling R-HSA-354192 1.414735e-01 0.849 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.734389e-01 0.242 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.783883e-01 0.422 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.783883e-01 0.422 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.378041e-01 0.624 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.382177e-01 0.471 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.268405e-01 0.897 0 0
Adipogenesis R-HSA-9843745 4.524760e-01 0.344 0 0
G-protein beta:gamma signalling R-HSA-397795 3.978700e-01 0.400 0 0
Formation of definitive endoderm R-HSA-9823730 1.116851e-01 0.952 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.046919e-01 0.980 0 0
Signaling by SCF-KIT R-HSA-1433557 2.252336e-01 0.647 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.688166e-01 0.571 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.808239e-01 0.743 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.492529e-01 0.603 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.101830e-01 0.292 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.892667e-01 0.723 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.693019e-02 1.014 0 0
EGFR downregulation R-HSA-182971 3.521551e-01 0.453 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.382177e-01 0.471 0 0
Signaling by EGFR R-HSA-177929 1.371255e-01 0.863 0 0
Telomere Extension By Telomerase R-HSA-171319 2.846552e-01 0.546 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.098794e-01 0.387 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.075837e-01 0.512 0 0
Protein folding R-HSA-391251 5.680665e-01 0.246 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.421751e-01 0.847 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.414735e-01 0.849 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.579761e-01 0.588 0 0
G0 and Early G1 R-HSA-1538133 3.749961e-01 0.426 0 0
Telomere Maintenance R-HSA-157579 4.363912e-01 0.360 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.404838e-01 0.356 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.077819e-01 0.967 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.344747e-01 0.871 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.143587e-01 0.942 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.223040e-02 1.035 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.864025e-01 0.730 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.492117e-01 0.603 0 0
Hedgehog 'off' state R-HSA-5610787 3.760663e-01 0.425 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.068683e-01 0.971 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.962134e-02 1.002 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.210328e-01 0.493 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.354281e-01 0.868 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.144527e-01 0.941 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.865101e-01 0.729 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.627852e-01 0.580 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.386105e-01 0.358 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.227853e-01 0.374 0 0
Cellular response to starvation R-HSA-9711097 4.381369e-01 0.358 0 0
ESR-mediated signaling R-HSA-8939211 2.366627e-01 0.626 0 0
Signaling by ERBB2 R-HSA-1227986 3.934863e-01 0.405 0 0
p75NTR signals via NF-kB R-HSA-193639 4.496394e-01 0.347 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.087048e-01 0.389 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.254595e-01 0.488 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.813667e-01 0.318 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.291179e-01 0.367 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 9.205384e-02 1.036 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.070045e-01 0.684 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.408748e-01 0.618 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.308376e-01 0.883 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.758834e-01 0.240 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.577617e-02 1.019 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.619577e-01 0.250 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.778935e-01 0.238 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.778935e-01 0.238 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.014191e-01 0.300 0 0
Apoptotic factor-mediated response R-HSA-111471 3.516821e-01 0.454 0 0
GAB1 signalosome R-HSA-180292 3.516821e-01 0.454 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.149554e-01 0.288 0 0
Signaling by WNT in cancer R-HSA-4791275 1.278024e-01 0.893 0 0
DNA Double Strand Break Response R-HSA-5693606 1.864025e-01 0.730 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.092753e-01 0.293 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.205384e-02 1.036 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.796155e-01 0.553 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.796155e-01 0.553 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.027890e-01 0.988 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.383629e-01 0.859 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.740042e-01 0.427 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.301484e-01 0.638 0 0
Processing of SMDT1 R-HSA-8949664 3.810175e-01 0.419 0 0
Peptide chain elongation R-HSA-156902 1.385139e-01 0.859 0 0
Homology Directed Repair R-HSA-5693538 1.027990e-01 0.988 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.910450e-01 0.536 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.156545e-01 0.381 0 0
Eukaryotic Translation Termination R-HSA-72764 2.267306e-01 0.644 0 0
Nuclear RNA decay R-HSA-9930044 3.978700e-01 0.400 0 0
Regulation of CDH11 function R-HSA-9762292 5.046379e-01 0.297 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.422510e-01 0.466 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.514413e-01 0.454 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.887734e-01 0.539 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.061123e-01 0.686 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.459464e-01 0.461 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.749961e-01 0.426 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.876375e-01 0.231 0 0
TNF signaling R-HSA-75893 2.182727e-01 0.661 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.836642e-02 1.054 0 0
S Phase R-HSA-69242 4.110577e-01 0.386 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.539588e-01 0.813 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.233354e-01 0.490 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.060778e-01 0.391 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.230884e-01 0.910 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.581803e-01 0.801 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.193734e-01 0.377 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.725948e-01 0.564 0 0
Regulation of gap junction activity R-HSA-191650 5.422768e-01 0.266 0 0
Potassium Channels R-HSA-1296071 2.378041e-01 0.624 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.496394e-01 0.347 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.541920e-01 0.343 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.149554e-01 0.288 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.367029e-01 0.360 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.882140e-01 0.311 0 0
NF-kB is activated and signals survival R-HSA-209560 5.813467e-01 0.236 0 0
PKA activation R-HSA-163615 5.758834e-01 0.240 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.873371e-01 0.727 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.873371e-01 0.727 0 0
Mitophagy R-HSA-5205647 2.887734e-01 0.539 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.674191e-01 0.435 0 0
Prolonged ERK activation events R-HSA-169893 2.649206e-01 0.577 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.414735e-01 0.849 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.272371e-01 0.278 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.413785e-01 0.617 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.408748e-01 0.618 0 0
Signal attenuation R-HSA-74749 2.408748e-01 0.618 0 0
Repression of WNT target genes R-HSA-4641265 3.459464e-01 0.461 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.045123e-01 0.689 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.068990e-01 0.513 0 0
Nuclear import of Rev protein R-HSA-180746 2.887734e-01 0.539 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.097877e-01 0.509 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.291179e-01 0.367 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.529948e-01 0.344 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.237749e-01 0.490 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.442958e-01 0.352 0 0
G2/M Checkpoints R-HSA-69481 8.482802e-02 1.071 0 0
Generation of second messenger molecules R-HSA-202433 2.725948e-01 0.564 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.443496e-01 0.841 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.712050e-01 0.430 0 0
Calmodulin induced events R-HSA-111933 1.140058e-01 0.943 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.065075e-01 0.973 0 0
Signaling by NOTCH1 R-HSA-1980143 1.409700e-01 0.851 0 0
Glycogen metabolism R-HSA-8982491 2.725948e-01 0.564 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.266424e-01 0.897 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.366926e-01 0.473 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.375924e-01 0.624 0 0
Sensory perception of sour taste R-HSA-9729555 1.845038e-01 0.734 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.887018e-02 1.051 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.832881e-01 0.737 0 0
Abacavir transmembrane transport R-HSA-2161517 3.272537e-01 0.485 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.368699e-01 0.625 0 0
CaM pathway R-HSA-111997 1.140058e-01 0.943 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.193734e-01 0.377 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.294279e-01 0.482 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.767085e-01 0.558 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.767085e-01 0.558 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.767085e-01 0.558 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.767085e-01 0.558 0 0
Tight junction interactions R-HSA-420029 3.783883e-01 0.422 0 0
Intraflagellar transport R-HSA-5620924 3.096032e-01 0.509 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.267410e-01 0.644 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.978700e-01 0.400 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.386105e-01 0.358 0 0
Formation of the posterior neural plate R-HSA-9832991 5.441177e-01 0.264 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.960911e-01 0.304 0 0
MET promotes cell motility R-HSA-8875878 5.317913e-01 0.274 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.813467e-01 0.236 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.739085e-01 0.241 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.737394e-01 0.241 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.890166e-01 0.410 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.514678e-01 0.820 0 0
PLC beta mediated events R-HSA-112043 1.227029e-01 0.911 0 0
TCR signaling R-HSA-202403 3.297821e-01 0.482 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.077501e-01 0.682 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.123116e-01 0.950 0 0
Gene expression (Transcription) R-HSA-74160 1.541967e-01 0.812 0 0
DAG and IP3 signaling R-HSA-1489509 9.135541e-02 1.039 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.195131e-01 0.659 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.688166e-01 0.571 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.978700e-01 0.400 0 0
RNA Polymerase II Transcription R-HSA-73857 1.002293e-01 0.999 0 0
Integration of energy metabolism R-HSA-163685 2.065006e-01 0.685 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.935356e-01 0.532 0 0
PERK regulates gene expression R-HSA-381042 4.659373e-01 0.332 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.641323e-01 0.333 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.641323e-01 0.333 0 0
Ca2+ pathway R-HSA-4086398 3.668280e-01 0.436 1 1
Signaling by VEGF R-HSA-194138 2.161442e-01 0.665 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.630018e-01 0.334 0 0
Signaling by WNT R-HSA-195721 2.557275e-01 0.592 1 0
Generic Transcription Pathway R-HSA-212436 1.408027e-01 0.851 0 0
Frs2-mediated activation R-HSA-170968 3.810175e-01 0.419 0 0
Opioid Signalling R-HSA-111885 1.226364e-01 0.911 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.276265e-01 0.894 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.845038e-01 0.734 0 0
Specification of the neural plate border R-HSA-9834899 2.061123e-01 0.686 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.027416e-01 0.693 0 0
Signaling by Hippo R-HSA-2028269 3.225179e-01 0.491 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.492529e-01 0.603 0 0
Meiotic recombination R-HSA-912446 2.446443e-01 0.611 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.046379e-01 0.297 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.060778e-01 0.391 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.101830e-01 0.292 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.813467e-01 0.236 0 0
Hedgehog 'on' state R-HSA-5632684 5.778935e-01 0.238 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.853592e-01 0.732 0 0
Signalling to ERKs R-HSA-187687 3.090568e-01 0.510 0 0
Transmission across Chemical Synapses R-HSA-112315 1.508470e-01 0.821 0 0
Ca-dependent events R-HSA-111996 2.094845e-01 0.679 0 0
Cardiogenesis R-HSA-9733709 2.492529e-01 0.603 0 0
G1/S Transition R-HSA-69206 3.694206e-01 0.432 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.117108e-01 0.385 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.165610e-01 0.664 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.673492e-01 0.776 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.755919e-01 0.323 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.739085e-01 0.241 0 0
DNA Repair R-HSA-73894 1.917545e-01 0.717 0 0
Cilium Assembly R-HSA-5617833 1.149779e-01 0.939 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.978386e-01 0.400 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.935356e-01 0.532 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.492529e-01 0.603 0 0
PTEN Regulation R-HSA-6807070 3.828511e-01 0.417 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.033258e-01 0.298 0 0
NGF-stimulated transcription R-HSA-9031628 1.202039e-01 0.920 0 0
Developmental Biology R-HSA-1266738 1.400534e-01 0.854 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.892272e-01 0.723 0 0
Smooth Muscle Contraction R-HSA-445355 2.761649e-01 0.559 0 0
Cleavage of the damaged purine R-HSA-110331 1.258690e-01 0.900 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.740042e-01 0.427 0 0
mRNA Editing R-HSA-75072 4.630018e-01 0.334 0 0
UCH proteinases R-HSA-5689603 1.409700e-01 0.851 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.356518e-01 0.628 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.356518e-01 0.628 0 0
Membrane Trafficking R-HSA-199991 1.524307e-01 0.817 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.482670e-01 0.261 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.669205e-01 0.331 0 0
Signaling by ALK in cancer R-HSA-9700206 2.165610e-01 0.664 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.714047e-01 0.766 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.149554e-01 0.288 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.086142e-01 0.511 0 0
Depurination R-HSA-73927 1.383629e-01 0.859 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.182727e-01 0.661 0 0
Host Interactions of HIV factors R-HSA-162909 4.350225e-01 0.361 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.075837e-01 0.512 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.823186e-01 0.235 0 0
G-protein mediated events R-HSA-112040 1.864025e-01 0.730 0 0
Cell junction organization R-HSA-446728 1.397834e-01 0.855 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.293065e-01 0.640 0 0
Inhibition of PKR R-HSA-169131 2.293065e-01 0.640 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.234229e-01 0.490 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.070045e-01 0.684 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.796155e-01 0.553 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.060508e-01 0.391 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.060508e-01 0.391 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.060508e-01 0.391 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.060508e-01 0.391 0 0
C6 deamination of adenosine R-HSA-75102 4.060508e-01 0.391 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.408748e-01 0.618 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.624505e-01 0.789 0 0
mTORC1-mediated signalling R-HSA-166208 1.621445e-01 0.790 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.755620e-01 0.560 0 0
Protein hydroxylation R-HSA-9629569 2.292530e-01 0.640 0 0
Signaling by AXIN mutants R-HSA-4839735 3.106967e-01 0.508 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.106967e-01 0.508 0 0
MET interacts with TNS proteins R-HSA-8875513 4.785918e-01 0.320 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.785918e-01 0.320 0 0
Signaling by LTK R-HSA-9842663 3.459464e-01 0.461 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.627852e-01 0.580 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.193734e-01 0.377 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.810175e-01 0.419 0 0
Platelet calcium homeostasis R-HSA-418360 3.068990e-01 0.513 0 0
The NLRP3 inflammasome R-HSA-844456 3.808554e-01 0.419 0 0
Transmission across Electrical Synapses R-HSA-112307 5.422768e-01 0.266 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.422768e-01 0.266 0 0
Alanine metabolism R-HSA-8964540 5.422768e-01 0.266 0 0
Cristae formation R-HSA-8949613 4.291179e-01 0.367 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.541920e-01 0.343 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.434113e-01 0.353 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.101830e-01 0.292 0 0
Sodium/Calcium exchangers R-HSA-425561 5.813467e-01 0.236 0 0
PKA activation in glucagon signalling R-HSA-164378 5.758834e-01 0.240 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.737394e-01 0.241 0 0
Adherens junctions interactions R-HSA-418990 4.519485e-01 0.345 0 0
Cell-cell junction organization R-HSA-421270 4.084917e-01 0.389 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.564333e-01 0.255 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.734389e-01 0.242 0 0
Signaling by ERBB4 R-HSA-1236394 1.230367e-01 0.910 0 0
Heme signaling R-HSA-9707616 2.079495e-01 0.682 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.564333e-01 0.255 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.564333e-01 0.255 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.729345e-01 0.762 0 0
Mitochondrial biogenesis R-HSA-1592230 5.383831e-01 0.269 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.038184e-01 0.394 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.813467e-01 0.236 0 0
Cell-Cell communication R-HSA-1500931 1.515239e-01 0.820 0 0
Pexophagy R-HSA-9664873 5.046379e-01 0.297 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.339661e-01 0.363 0 0
FLT3 signaling in disease R-HSA-9682385 4.882140e-01 0.311 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.223774e-01 0.282 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.223774e-01 0.282 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.568766e-01 0.804 0 0
Gap junction trafficking and regulation R-HSA-157858 3.273169e-01 0.485 0 0
Interferon Signaling R-HSA-913531 4.973196e-01 0.303 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.003111e-01 0.698 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.361677e-01 0.473 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.737170e-01 0.241 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.130786e-01 0.384 0 0
Downstream signal transduction R-HSA-186763 3.521551e-01 0.453 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.902219e-01 0.537 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.789541e-01 0.320 0 0
Interleukin-1 family signaling R-HSA-446652 3.734283e-01 0.428 0 0
Signaling by PTK6 R-HSA-8848021 5.766305e-01 0.239 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.766305e-01 0.239 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.504518e-01 0.823 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.561817e-01 0.341 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.408748e-01 0.618 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.140233e-02 1.039 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.193734e-01 0.377 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.827513e-01 0.738 0 0
Rab regulation of trafficking R-HSA-9007101 1.409664e-01 0.851 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.630018e-01 0.334 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.149554e-01 0.288 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.056457e-01 0.392 0 0
Formation of the nephric duct R-HSA-9830364 1.143587e-01 0.942 0 0
Activation of BH3-only proteins R-HSA-114452 1.935738e-01 0.713 0 0
Co-stimulation by CD28 R-HSA-389356 2.000390e-01 0.699 0 0
Regulation of insulin secretion R-HSA-422356 4.502318e-01 0.347 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.317465e-01 0.635 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.070045e-01 0.684 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.796155e-01 0.553 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.832881e-01 0.737 0 0
Nef and signal transduction R-HSA-164944 3.272537e-01 0.485 0 0
Syndecan interactions R-HSA-3000170 1.808239e-01 0.743 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.740042e-01 0.427 0 0
Glucose metabolism R-HSA-70326 9.697492e-02 1.013 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.156545e-01 0.381 0 0
Interleukin-1 processing R-HSA-448706 4.630018e-01 0.334 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.630018e-01 0.334 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.630018e-01 0.334 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.630018e-01 0.334 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.422768e-01 0.266 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.496394e-01 0.347 0 0
Gap junction trafficking R-HSA-190828 3.672504e-01 0.435 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.310008e-01 0.636 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.514413e-01 0.454 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.206994e-01 0.376 0 0
LGI-ADAM interactions R-HSA-5682910 5.441177e-01 0.264 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.453830e-01 0.837 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.887734e-01 0.539 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.767085e-01 0.558 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.027990e-01 0.988 0 0
Ion channel transport R-HSA-983712 4.557296e-01 0.341 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.433541e-01 0.844 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.038184e-01 0.394 0 0
TGFBR3 expression R-HSA-9839394 5.739085e-01 0.241 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.739085e-01 0.241 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.838030e-01 0.736 0 0
Amine ligand-binding receptors R-HSA-375280 5.159334e-01 0.287 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.210328e-01 0.493 0 0
PI Metabolism R-HSA-1483255 4.026737e-01 0.395 0 0
G1/S-Specific Transcription R-HSA-69205 1.140058e-01 0.943 0 0
TBC/RABGAPs R-HSA-8854214 4.957769e-01 0.305 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.460174e-01 0.263 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.392570e-01 0.469 0 0
Signaling by TGFBR3 R-HSA-9839373 5.553189e-01 0.255 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.581803e-01 0.801 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.796155e-01 0.553 0 0
DSCAM interactions R-HSA-376172 4.060508e-01 0.391 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.408748e-01 0.618 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.838030e-01 0.736 0 0
Synthesis of PI R-HSA-1483226 2.755620e-01 0.560 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.785918e-01 0.320 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.630018e-01 0.334 0 0
NADE modulates death signalling R-HSA-205025 5.422768e-01 0.266 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.386105e-01 0.358 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.046379e-01 0.297 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.921388e-01 0.407 0 0
Negative regulation of FLT3 R-HSA-9706369 4.827896e-01 0.316 0 0
Activation of SMO R-HSA-5635838 4.827896e-01 0.316 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.753659e-01 0.323 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.482670e-01 0.261 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.100858e-01 0.958 0 0
Diseases of DNA repair R-HSA-9675135 2.748909e-01 0.561 0 0
Base Excision Repair R-HSA-73884 5.253004e-01 0.280 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.911408e-01 0.719 0 0
MAP kinase activation R-HSA-450294 5.427106e-01 0.265 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.286042e-01 0.891 0 0
Sensory processing of sound R-HSA-9659379 1.106436e-01 0.956 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.514678e-01 0.820 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.743541e-01 0.759 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.209270e-01 0.283 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.386105e-01 0.358 0 0
Histamine receptors R-HSA-390650 4.785918e-01 0.320 0 0
Selenocysteine synthesis R-HSA-2408557 3.893448e-01 0.410 0 0
Formation of the anterior neural plate R-HSA-9823739 4.496394e-01 0.347 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.232462e-01 0.909 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.740042e-01 0.427 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.785918e-01 0.320 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.371255e-01 0.863 0 0
Interleukin-18 signaling R-HSA-9012546 4.193734e-01 0.377 0 0
Sodium/Proton exchangers R-HSA-425986 4.193734e-01 0.377 0 0
Dopamine receptors R-HSA-390651 5.422768e-01 0.266 0 0
Gap junction assembly R-HSA-190861 4.434113e-01 0.353 0 0
Passive transport by Aquaporins R-HSA-432047 5.149554e-01 0.288 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.218397e-01 0.282 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.737394e-01 0.241 0 0
Signaling by Interleukins R-HSA-449147 1.251412e-01 0.903 0 0
Depyrimidination R-HSA-73928 1.232462e-01 0.909 0 0
Nephrin family interactions R-HSA-373753 2.292530e-01 0.640 0 0
Interleukin-7 signaling R-HSA-1266695 5.739085e-01 0.241 0 0
Specification of primordial germ cells R-HSA-9827857 3.225179e-01 0.491 0 0
Influenza Infection R-HSA-168255 4.311806e-01 0.365 0 0
OAS antiviral response R-HSA-8983711 1.581803e-01 0.801 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.755620e-01 0.560 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.496394e-01 0.347 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.516821e-01 0.454 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.810175e-01 0.419 0 0
Vasopressin-like receptors R-HSA-388479 5.422768e-01 0.266 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.669205e-01 0.331 0 0
Signaling by Leptin R-HSA-2586552 5.046379e-01 0.297 0 0
Interleukin-12 family signaling R-HSA-447115 1.301258e-01 0.886 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.932300e-01 0.227 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.939991e-01 0.226 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.939991e-01 0.226 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.945496e-01 0.226 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.956297e-01 0.225 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.956297e-01 0.225 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.957209e-01 0.225 0 0
Activation of AMPA receptors R-HSA-399710 5.981866e-01 0.223 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.981866e-01 0.223 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.981866e-01 0.223 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.981866e-01 0.223 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.981866e-01 0.223 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.981866e-01 0.223 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.981866e-01 0.223 0 0
Defective F9 activation R-HSA-9673221 5.981866e-01 0.223 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.981866e-01 0.223 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.981866e-01 0.223 0 0
Suppression of autophagy R-HSA-9636569 5.981866e-01 0.223 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.981866e-01 0.223 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.981866e-01 0.223 0 0
PTK6 Down-Regulation R-HSA-8849472 5.981866e-01 0.223 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.987069e-01 0.223 0 0
HCMV Early Events R-HSA-9609690 6.011493e-01 0.221 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.044860e-01 0.219 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.044860e-01 0.219 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.044860e-01 0.219 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.044860e-01 0.219 0 0
Other interleukin signaling R-HSA-449836 6.044860e-01 0.219 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.050542e-01 0.218 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.089735e-01 0.215 0 0
Regulation of CDH1 Function R-HSA-9764561 6.101894e-01 0.215 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.137376e-01 0.212 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.137376e-01 0.212 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.162858e-01 0.210 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.162858e-01 0.210 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.162858e-01 0.210 0 0
Polymerase switching R-HSA-69091 6.162858e-01 0.210 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.162858e-01 0.210 0 0
Leading Strand Synthesis R-HSA-69109 6.162858e-01 0.210 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.162858e-01 0.210 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.162858e-01 0.210 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.162858e-01 0.210 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.162858e-01 0.210 0 0
Estrogen biosynthesis R-HSA-193144 6.162858e-01 0.210 0 0
Interleukin-15 signaling R-HSA-8983432 6.162858e-01 0.210 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.171599e-01 0.210 0 0
Cellular response to chemical stress R-HSA-9711123 6.203598e-01 0.207 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.226175e-01 0.206 0 0
Insulin processing R-HSA-264876 6.226175e-01 0.206 0 0
Signaling by FGFR in disease R-HSA-1226099 6.240837e-01 0.205 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.269843e-01 0.203 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.317791e-01 0.199 0 0
Signaling by NODAL R-HSA-1181150 6.317791e-01 0.199 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.329274e-01 0.199 0 0
Signaling by Hedgehog R-HSA-5358351 6.348982e-01 0.197 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.351425e-01 0.197 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.356551e-01 0.197 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.379981e-01 0.195 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.388871e-01 0.195 0 0
Kidney development R-HSA-9830369 6.408074e-01 0.193 0 0
Extension of Telomeres R-HSA-180786 6.433778e-01 0.192 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.456064e-01 0.190 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.456064e-01 0.190 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.456064e-01 0.190 0 0
Pyroptosis R-HSA-5620971 6.456064e-01 0.190 0 0
Inflammasomes R-HSA-622312 6.456064e-01 0.190 0 0
Circadian clock R-HSA-9909396 6.457520e-01 0.190 0 0
Plus-strand DNA synthesis R-HSA-164525 6.472700e-01 0.189 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.472700e-01 0.189 0 0
PKB-mediated events R-HSA-109703 6.472700e-01 0.189 0 0
PDE3B signalling R-HSA-165160 6.472700e-01 0.189 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.472700e-01 0.189 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.472700e-01 0.189 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.472700e-01 0.189 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.472700e-01 0.189 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.472700e-01 0.189 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.472700e-01 0.189 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.472700e-01 0.189 0 0
Terminal pathway of complement R-HSA-166665 6.472700e-01 0.189 0 0
Signaling by MST1 R-HSA-8852405 6.472700e-01 0.189 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.472700e-01 0.189 0 0
NGF-independant TRKA activation R-HSA-187024 6.472700e-01 0.189 0 0
Formation of the Editosome R-HSA-75094 6.472700e-01 0.189 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.472700e-01 0.189 0 0
Phosphorylation of Emi1 R-HSA-176417 6.472700e-01 0.189 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.472700e-01 0.189 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.472700e-01 0.189 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.472700e-01 0.189 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.472700e-01 0.189 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.472700e-01 0.189 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.489390e-01 0.188 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.489390e-01 0.188 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.489390e-01 0.188 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.489390e-01 0.188 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.489390e-01 0.188 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.489390e-01 0.188 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.489390e-01 0.188 0 0
Signaling by NOTCH R-HSA-157118 6.498846e-01 0.187 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.513331e-01 0.186 0 0
Transcription of the HIV genome R-HSA-167172 6.559841e-01 0.183 0 0
Regulated Necrosis R-HSA-5218859 6.559841e-01 0.183 0 0
Signalling to RAS R-HSA-167044 6.577358e-01 0.182 0 0
ERK/MAPK targets R-HSA-198753 6.577358e-01 0.182 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.581195e-01 0.182 0 0
Orc1 removal from chromatin R-HSA-68949 6.637468e-01 0.178 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.637468e-01 0.178 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.637468e-01 0.178 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.652920e-01 0.177 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.676499e-01 0.175 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.680263e-01 0.175 0 0
G1 Phase R-HSA-69236 6.695734e-01 0.174 0 0
Cyclin D associated events in G1 R-HSA-69231 6.695734e-01 0.174 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.741730e-01 0.171 0 0
Removal of the Flap Intermediate R-HSA-69166 6.793432e-01 0.168 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.793432e-01 0.168 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.793432e-01 0.168 0 0
HDL assembly R-HSA-8963896 6.793432e-01 0.168 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.793432e-01 0.168 0 0
Physiological factors R-HSA-5578768 6.793432e-01 0.168 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.793432e-01 0.168 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.801549e-01 0.167 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.801549e-01 0.167 0 0
Metabolism of RNA R-HSA-8953854 6.818125e-01 0.166 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.823454e-01 0.166 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.823454e-01 0.166 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.823454e-01 0.166 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.823454e-01 0.166 0 0
Interleukin-17 signaling R-HSA-448424 6.852022e-01 0.164 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.869968e-01 0.163 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.869968e-01 0.163 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.869971e-01 0.163 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.887335e-01 0.162 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.887335e-01 0.162 0 0
DAP12 signaling R-HSA-2424491 6.887335e-01 0.162 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.887335e-01 0.162 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.887335e-01 0.162 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.903601e-01 0.161 0 0
STAT5 Activation R-HSA-9645135 6.903601e-01 0.161 0 0
Uncoating of the HIV Virion R-HSA-162585 6.903601e-01 0.161 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.903601e-01 0.161 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.903601e-01 0.161 0 0
NADPH regeneration R-HSA-389542 6.903601e-01 0.161 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.903601e-01 0.161 0 0
Lipid particle organization R-HSA-8964572 6.903601e-01 0.161 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.928121e-01 0.159 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.949285e-01 0.158 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.961441e-01 0.157 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.974103e-01 0.157 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.992243e-01 0.155 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.038053e-01 0.153 0 0
Signaling by TGFB family members R-HSA-9006936 7.040181e-01 0.152 0 0
Signaling by KIT in disease R-HSA-9669938 7.056112e-01 0.151 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.056112e-01 0.151 0 0
FGFR2 alternative splicing R-HSA-6803529 7.056112e-01 0.151 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.056112e-01 0.151 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.056112e-01 0.151 0 0
Ethanol oxidation R-HSA-71384 7.056112e-01 0.151 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.056112e-01 0.151 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.056112e-01 0.151 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.061598e-01 0.151 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.075607e-01 0.150 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.075607e-01 0.150 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.075607e-01 0.150 0 0
p38MAPK events R-HSA-171007 7.075607e-01 0.150 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.075607e-01 0.150 0 0
Protein methylation R-HSA-8876725 7.075607e-01 0.150 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.075607e-01 0.150 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.075607e-01 0.150 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.079011e-01 0.150 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.088508e-01 0.149 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.088508e-01 0.149 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.089723e-01 0.149 0 0
Signaling by ALK R-HSA-201556 7.140270e-01 0.146 0 0
Ribosome-associated quality control R-HSA-9948299 7.179458e-01 0.144 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.206437e-01 0.142 0 0
Neutrophil degranulation R-HSA-6798695 7.251154e-01 0.140 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.262562e-01 0.139 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.262562e-01 0.139 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.275482e-01 0.138 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.280027e-01 0.138 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.281885e-01 0.138 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.281885e-01 0.138 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.281885e-01 0.138 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.281885e-01 0.138 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.281885e-01 0.138 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.281885e-01 0.138 0 0
Recycling of eIF2:GDP R-HSA-72731 7.281885e-01 0.138 0 0
Disinhibition of SNARE formation R-HSA-114516 7.281885e-01 0.138 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.281885e-01 0.138 0 0
PTK6 Expression R-HSA-8849473 7.281885e-01 0.138 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.281885e-01 0.138 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.281885e-01 0.138 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.281885e-01 0.138 0 0
Activation of TRKA receptors R-HSA-187015 7.281885e-01 0.138 0 0
Glycoprotein hormones R-HSA-209822 7.281885e-01 0.138 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.281885e-01 0.138 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.281885e-01 0.138 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.281885e-01 0.138 0 0
CHL1 interactions R-HSA-447041 7.281885e-01 0.138 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.311518e-01 0.136 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.311518e-01 0.136 0 0
Interleukin-2 family signaling R-HSA-451927 7.311518e-01 0.136 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.336717e-01 0.134 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.336717e-01 0.134 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.336717e-01 0.134 0 0
Differentiation of T cells R-HSA-9945266 7.336717e-01 0.134 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.336717e-01 0.134 0 0
Fructose catabolism R-HSA-70350 7.336717e-01 0.134 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.336717e-01 0.134 0 0
Regulation of BACH1 activity R-HSA-9708530 7.336717e-01 0.134 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.336717e-01 0.134 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.336717e-01 0.134 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.336717e-01 0.134 0 0
Metal ion SLC transporters R-HSA-425410 7.355539e-01 0.133 0 0
HIV Infection R-HSA-162906 7.371790e-01 0.132 0 0
Signaling by NOTCH4 R-HSA-9013694 7.388632e-01 0.131 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.392609e-01 0.131 0 0
Adaptive Immune System R-HSA-1280218 7.410880e-01 0.130 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.450494e-01 0.128 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.450494e-01 0.128 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.461966e-01 0.127 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.462186e-01 0.127 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.475202e-01 0.126 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.481813e-01 0.126 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.481813e-01 0.126 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.481813e-01 0.126 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.485084e-01 0.126 0 0
Degradation of CDH1 R-HSA-9766229 7.504905e-01 0.125 0 0
Platelet degranulation R-HSA-114608 7.514985e-01 0.124 0 0
Nucleotide Excision Repair R-HSA-5696398 7.524296e-01 0.124 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.577699e-01 0.120 0 0
Disorders of Developmental Biology R-HSA-9675151 7.577699e-01 0.120 0 0
Synthesis of PG R-HSA-1483148 7.577699e-01 0.120 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.613973e-01 0.118 0 0
Minus-strand DNA synthesis R-HSA-164516 7.613973e-01 0.118 0 0
RSK activation R-HSA-444257 7.613973e-01 0.118 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.613973e-01 0.118 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.613973e-01 0.118 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.613973e-01 0.118 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.613973e-01 0.118 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.613973e-01 0.118 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.613973e-01 0.118 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.613973e-01 0.118 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.613973e-01 0.118 0 0
Regulation by c-FLIP R-HSA-3371378 7.613973e-01 0.118 0 0
Co-stimulation by ICOS R-HSA-9927354 7.613973e-01 0.118 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.613973e-01 0.118 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.613973e-01 0.118 0 0
Dimerization of procaspase-8 R-HSA-69416 7.613973e-01 0.118 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.613973e-01 0.118 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.613973e-01 0.118 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.613973e-01 0.118 0 0
Alpha-defensins R-HSA-1462054 7.613973e-01 0.118 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.613973e-01 0.118 0 0
Platelet homeostasis R-HSA-418346 7.625831e-01 0.118 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.631378e-01 0.117 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.648044e-01 0.116 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.689855e-01 0.114 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.701717e-01 0.113 0 0
Gene Silencing by RNA R-HSA-211000 7.724497e-01 0.112 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.734514e-01 0.112 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.734514e-01 0.112 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.774964e-01 0.109 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.785006e-01 0.109 0 0
Dual Incision in GG-NER R-HSA-5696400 7.797663e-01 0.108 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.797663e-01 0.108 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.797663e-01 0.108 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.799572e-01 0.108 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.799572e-01 0.108 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.799572e-01 0.108 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.799572e-01 0.108 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.799572e-01 0.108 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.799572e-01 0.108 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.799572e-01 0.108 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.799572e-01 0.108 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.799572e-01 0.108 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.856729e-01 0.105 0 0
Interleukin-21 signaling R-HSA-9020958 7.905505e-01 0.102 0 0
CASP8 activity is inhibited R-HSA-5218900 7.905505e-01 0.102 0 0
Unwinding of DNA R-HSA-176974 7.905505e-01 0.102 0 0
WNT mediated activation of DVL R-HSA-201688 7.905505e-01 0.102 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.905505e-01 0.102 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.905505e-01 0.102 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.905505e-01 0.102 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.905505e-01 0.102 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.905505e-01 0.102 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.905505e-01 0.102 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.905505e-01 0.102 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.905505e-01 0.102 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.905505e-01 0.102 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.905505e-01 0.102 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.915867e-01 0.102 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.924788e-01 0.101 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.924788e-01 0.101 0 0
Aquaporin-mediated transport R-HSA-445717 7.924788e-01 0.101 0 0
Vesicle-mediated transport R-HSA-5653656 7.970927e-01 0.098 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.003407e-01 0.097 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.003407e-01 0.097 0 0
Mismatch Repair R-HSA-5358508 8.003407e-01 0.097 0 0
Tie2 Signaling R-HSA-210993 8.003407e-01 0.097 0 0
Platelet sensitization by LDL R-HSA-432142 8.003407e-01 0.097 0 0
G alpha (s) signalling events R-HSA-418555 8.023352e-01 0.096 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.026146e-01 0.095 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.026146e-01 0.095 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.026146e-01 0.095 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.040721e-01 0.095 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.041497e-01 0.095 0 0
Signaling by PDGF R-HSA-186797 8.041497e-01 0.095 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.055902e-01 0.094 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.070329e-01 0.093 0 0
Immune System R-HSA-168256 8.095288e-01 0.092 0 0
RNA Polymerase III Transcription R-HSA-74158 8.097147e-01 0.092 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.097147e-01 0.092 0 0
Triglyceride catabolism R-HSA-163560 8.097147e-01 0.092 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.097147e-01 0.092 0 0
GPVI-mediated activation cascade R-HSA-114604 8.097147e-01 0.092 0 0
HIV Life Cycle R-HSA-162587 8.154422e-01 0.089 0 0
Translation initiation complex formation R-HSA-72649 8.159679e-01 0.088 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.159679e-01 0.088 0 0
Binding and entry of HIV virion R-HSA-173107 8.161432e-01 0.088 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.161432e-01 0.088 0 0
DNA replication initiation R-HSA-68952 8.161432e-01 0.088 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.161432e-01 0.088 0 0
Metabolism of serotonin R-HSA-380612 8.161432e-01 0.088 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.161432e-01 0.088 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.161432e-01 0.088 0 0
Arachidonate production from DAG R-HSA-426048 8.161432e-01 0.088 0 0
Maturation of spike protein R-HSA-9683686 8.161432e-01 0.088 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.161432e-01 0.088 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.161432e-01 0.088 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.161432e-01 0.088 0 0
Sperm Motility And Taxes R-HSA-1300642 8.161432e-01 0.088 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.161432e-01 0.088 0 0
Peptide hormone biosynthesis R-HSA-209952 8.161432e-01 0.088 0 0
Serotonin receptors R-HSA-390666 8.161432e-01 0.088 0 0
Amyloid fiber formation R-HSA-977225 8.169723e-01 0.088 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.183225e-01 0.087 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.183225e-01 0.087 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.184160e-01 0.087 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.190299e-01 0.087 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.190299e-01 0.087 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.190299e-01 0.087 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.228975e-01 0.085 0 0
IGF1R signaling cascade R-HSA-2428924 8.259722e-01 0.083 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.272870e-01 0.082 0 0
Signaling by NOTCH3 R-HSA-9012852 8.272870e-01 0.082 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.297044e-01 0.081 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.303752e-01 0.081 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.303752e-01 0.081 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.303752e-01 0.081 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.331276e-01 0.079 0 0
mRNA Capping R-HSA-72086 8.331276e-01 0.079 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.331276e-01 0.079 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.331276e-01 0.079 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.361344e-01 0.078 0 0
Glycogen synthesis R-HSA-3322077 8.361344e-01 0.078 0 0
Signal transduction by L1 R-HSA-445144 8.361344e-01 0.078 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.361436e-01 0.078 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.366186e-01 0.077 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.380434e-01 0.077 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.386100e-01 0.076 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.386100e-01 0.076 0 0
Interleukin-2 signaling R-HSA-9020558 8.386100e-01 0.076 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.386100e-01 0.076 0 0
vRNA Synthesis R-HSA-192814 8.386100e-01 0.076 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.386100e-01 0.076 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.386100e-01 0.076 0 0
Bicarbonate transporters R-HSA-425381 8.386100e-01 0.076 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.386100e-01 0.076 0 0
Transport of RCbl within the body R-HSA-9758890 8.386100e-01 0.076 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.386100e-01 0.076 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.386100e-01 0.076 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.386100e-01 0.076 0 0
PECAM1 interactions R-HSA-210990 8.386100e-01 0.076 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.407759e-01 0.075 1 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.417684e-01 0.075 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.450531e-01 0.073 0 0
DNA Replication R-HSA-69306 8.458949e-01 0.073 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.468012e-01 0.072 0 0
Synthesis of DNA R-HSA-69239 8.469874e-01 0.072 0 0
IRS-mediated signalling R-HSA-112399 8.482523e-01 0.071 0 0
Stabilization of p53 R-HSA-69541 8.483129e-01 0.071 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.517624e-01 0.070 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.517624e-01 0.070 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.517624e-01 0.070 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.517624e-01 0.070 0 0
Lagging Strand Synthesis R-HSA-69186 8.517624e-01 0.070 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.517624e-01 0.070 0 0
Basigin interactions R-HSA-210991 8.517624e-01 0.070 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.517624e-01 0.070 0 0
Gluconeogenesis R-HSA-70263 8.525236e-01 0.069 0 0
Developmental Cell Lineages R-HSA-9734767 8.555123e-01 0.068 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.579299e-01 0.067 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.583326e-01 0.066 0 0
Plasmalogen biosynthesis R-HSA-75896 8.583326e-01 0.066 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.583326e-01 0.066 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.583326e-01 0.066 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.583326e-01 0.066 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.583326e-01 0.066 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.583326e-01 0.066 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.583326e-01 0.066 0 0
Integration of provirus R-HSA-162592 8.583326e-01 0.066 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.594899e-01 0.066 0 0
Budding and maturation of HIV virion R-HSA-162588 8.594899e-01 0.066 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.594899e-01 0.066 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.596151e-01 0.066 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.596151e-01 0.066 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.596151e-01 0.066 0 0
Selenoamino acid metabolism R-HSA-2408522 8.603751e-01 0.065 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.605936e-01 0.065 0 0
Interleukin-1 signaling R-HSA-9020702 8.608238e-01 0.065 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.660192e-01 0.062 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.660192e-01 0.062 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.660192e-01 0.062 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.660192e-01 0.062 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.670931e-01 0.062 0 0
Triglyceride metabolism R-HSA-8979227 8.670931e-01 0.062 0 0
rRNA processing R-HSA-72312 8.686521e-01 0.061 0 0
DNA strand elongation R-HSA-69190 8.712469e-01 0.060 0 0
Toll-like Receptor Cascades R-HSA-168898 8.721001e-01 0.059 0 0
PI3K Cascade R-HSA-109704 8.722109e-01 0.059 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.750316e-01 0.058 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.756460e-01 0.058 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.756460e-01 0.058 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.756460e-01 0.058 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.756460e-01 0.058 0 0
MET activates RAS signaling R-HSA-8851805 8.756460e-01 0.058 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.756460e-01 0.058 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.756460e-01 0.058 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.756460e-01 0.058 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.756460e-01 0.058 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.756460e-01 0.058 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.756460e-01 0.058 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.756460e-01 0.058 0 0
Disorders of Nervous System Development R-HSA-9697154 8.756460e-01 0.058 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.756460e-01 0.058 0 0
Pervasive developmental disorders R-HSA-9005895 8.756460e-01 0.058 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.756460e-01 0.058 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.790065e-01 0.056 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.790065e-01 0.056 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.790065e-01 0.056 0 0
Fructose metabolism R-HSA-5652084 8.790065e-01 0.056 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.790065e-01 0.056 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.790065e-01 0.056 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.800713e-01 0.055 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.800713e-01 0.055 0 0
HIV Transcription Initiation R-HSA-167161 8.800713e-01 0.055 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.800713e-01 0.055 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.800713e-01 0.055 0 0
Intra-Golgi traffic R-HSA-6811438 8.800713e-01 0.055 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.800713e-01 0.055 0 0
Inositol phosphate metabolism R-HSA-1483249 8.811101e-01 0.055 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.812260e-01 0.055 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.839466e-01 0.054 0 0
Signaling by MET R-HSA-6806834 8.847581e-01 0.053 0 0
GPCR downstream signalling R-HSA-388396 8.888392e-01 0.051 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.889439e-01 0.051 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.896239e-01 0.051 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.896239e-01 0.051 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.908216e-01 0.050 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.908216e-01 0.050 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.908216e-01 0.050 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.908216e-01 0.050 0 0
Formation of the ureteric bud R-HSA-9830674 8.908216e-01 0.050 0 0
Carnitine shuttle R-HSA-200425 8.908216e-01 0.050 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.908216e-01 0.050 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.908216e-01 0.050 0 0
Growth hormone receptor signaling R-HSA-982772 8.908216e-01 0.050 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.908444e-01 0.050 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.908444e-01 0.050 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.908444e-01 0.050 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.908444e-01 0.050 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.908444e-01 0.050 0 0
Chylomicron remodeling R-HSA-8963901 8.908444e-01 0.050 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.908444e-01 0.050 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.908444e-01 0.050 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.908444e-01 0.050 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.908444e-01 0.050 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.908444e-01 0.050 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.908444e-01 0.050 0 0
Maturation of nucleoprotein R-HSA-9683610 8.908444e-01 0.050 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.916729e-01 0.050 0 0
tRNA processing in the nucleus R-HSA-6784531 8.916729e-01 0.050 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.921761e-01 0.050 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.921761e-01 0.050 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.921761e-01 0.050 0 0
Hemostasis R-HSA-109582 8.933152e-01 0.049 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.946700e-01 0.048 0 0
Neurotransmitter release cycle R-HSA-112310 8.959266e-01 0.048 0 0
G alpha (q) signalling events R-HSA-416476 8.959505e-01 0.048 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.978871e-01 0.047 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.978871e-01 0.047 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.989567e-01 0.046 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.014513e-01 0.045 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.014513e-01 0.045 0 0
RA biosynthesis pathway R-HSA-5365859 9.014513e-01 0.045 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.015570e-01 0.045 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.015570e-01 0.045 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.015570e-01 0.045 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.019708e-01 0.045 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.041860e-01 0.044 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.041860e-01 0.044 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.041860e-01 0.044 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.041860e-01 0.044 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.041860e-01 0.044 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.041860e-01 0.044 0 0
Malate-aspartate shuttle R-HSA-9856872 9.041860e-01 0.044 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.041860e-01 0.044 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.041860e-01 0.044 0 0
Ciprofloxacin ADME R-HSA-9793528 9.041860e-01 0.044 0 0
Signal regulatory protein family interactions R-HSA-391160 9.041860e-01 0.044 0 0
Zinc transporters R-HSA-435354 9.041860e-01 0.044 0 0
P2Y receptors R-HSA-417957 9.041860e-01 0.044 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.043915e-01 0.044 0 0
Insulin receptor signalling cascade R-HSA-74751 9.058164e-01 0.043 0 0
DAP12 interactions R-HSA-2172127 9.058882e-01 0.043 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.080009e-01 0.042 0 0
Regulation of Apoptosis R-HSA-169911 9.099998e-01 0.041 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.099998e-01 0.041 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.099998e-01 0.041 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.113000e-01 0.040 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.113000e-01 0.040 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.113000e-01 0.040 0 0
G protein gated Potassium channels R-HSA-1296059 9.113000e-01 0.040 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.113000e-01 0.040 0 0
Laminin interactions R-HSA-3000157 9.113000e-01 0.040 0 0
Co-inhibition by PD-1 R-HSA-389948 9.116717e-01 0.040 0 0
Cellular response to hypoxia R-HSA-1234174 9.122702e-01 0.040 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.133283e-01 0.039 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.133283e-01 0.039 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.158976e-01 0.038 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.158976e-01 0.038 0 0
Protein lipoylation R-HSA-9857492 9.158976e-01 0.038 0 0
Signaling by Activin R-HSA-1502540 9.158976e-01 0.038 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.158976e-01 0.038 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.158976e-01 0.038 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.158976e-01 0.038 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.158976e-01 0.038 0 0
Biotin transport and metabolism R-HSA-196780 9.158976e-01 0.038 0 0
Other semaphorin interactions R-HSA-416700 9.158976e-01 0.038 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.158976e-01 0.038 0 0
DNA Damage Reversal R-HSA-73942 9.158976e-01 0.038 0 0
Gastrulation R-HSA-9758941 9.165402e-01 0.038 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.166179e-01 0.038 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.178695e-01 0.037 0 0
RUNX2 regulates bone development R-HSA-8941326 9.178695e-01 0.037 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.193814e-01 0.037 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.201328e-01 0.036 0 0
Myogenesis R-HSA-525793 9.201328e-01 0.036 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.201328e-01 0.036 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.201328e-01 0.036 0 0
Abacavir ADME R-HSA-2161522 9.201328e-01 0.036 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.201328e-01 0.036 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.202391e-01 0.036 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.202391e-01 0.036 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.251061e-01 0.034 0 0
Degradation of AXIN R-HSA-4641257 9.251061e-01 0.034 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.260977e-01 0.033 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.261783e-01 0.033 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.261783e-01 0.033 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.261783e-01 0.033 0 0
Killing mechanisms R-HSA-9664420 9.261783e-01 0.033 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.261783e-01 0.033 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.261783e-01 0.033 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.261783e-01 0.033 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.261783e-01 0.033 0 0
Atorvastatin ADME R-HSA-9754706 9.261783e-01 0.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.266516e-01 0.033 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.269018e-01 0.033 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.281322e-01 0.032 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.281322e-01 0.032 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.281322e-01 0.032 0 0
Triglyceride biosynthesis R-HSA-75109 9.281322e-01 0.032 0 0
Synthesis of PE R-HSA-1483213 9.281322e-01 0.032 0 0
RNA Polymerase I Transcription R-HSA-73864 9.297334e-01 0.032 0 0
Elastic fibre formation R-HSA-1566948 9.317536e-01 0.031 0 0
GPER1 signaling R-HSA-9634597 9.325955e-01 0.030 0 0
HCMV Infection R-HSA-9609646 9.345634e-01 0.029 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.352028e-01 0.029 0 0
Translesion synthesis by POLK R-HSA-5655862 9.352028e-01 0.029 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.352028e-01 0.029 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.352028e-01 0.029 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.352028e-01 0.029 0 0
Glycine degradation R-HSA-6783984 9.352028e-01 0.029 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.352028e-01 0.029 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.352028e-01 0.029 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.352028e-01 0.029 0 0
Galactose catabolism R-HSA-70370 9.352028e-01 0.029 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.352028e-01 0.029 0 0
Coenzyme A biosynthesis R-HSA-196783 9.352028e-01 0.029 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.352028e-01 0.029 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.352028e-01 0.029 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.353700e-01 0.029 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.353700e-01 0.029 0 0
Regulation of beta-cell development R-HSA-186712 9.354055e-01 0.029 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.378535e-01 0.028 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.378535e-01 0.028 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.390792e-01 0.027 0 0
RAB geranylgeranylation R-HSA-8873719 9.403265e-01 0.027 0 0
GABA receptor activation R-HSA-977443 9.403265e-01 0.027 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.403265e-01 0.027 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.419129e-01 0.026 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.419129e-01 0.026 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.419129e-01 0.026 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.428144e-01 0.026 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.431245e-01 0.025 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.431245e-01 0.025 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.431245e-01 0.025 0 0
Glycogen storage diseases R-HSA-3229121 9.431245e-01 0.025 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.431245e-01 0.025 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.431245e-01 0.025 0 0
Catecholamine biosynthesis R-HSA-209905 9.431245e-01 0.025 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.431245e-01 0.025 0 0
Choline catabolism R-HSA-6798163 9.431245e-01 0.025 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.431245e-01 0.025 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.431921e-01 0.025 0 0
Downstream TCR signaling R-HSA-202424 9.433971e-01 0.025 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.434456e-01 0.025 0 0
Diseases of Immune System R-HSA-5260271 9.434456e-01 0.025 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.437261e-01 0.025 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.478224e-01 0.023 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.478224e-01 0.023 0 0
Neurotransmitter clearance R-HSA-112311 9.478224e-01 0.023 0 0
The phototransduction cascade R-HSA-2514856 9.478990e-01 0.023 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.485674e-01 0.023 0 0
Maturation of spike protein R-HSA-9694548 9.485674e-01 0.023 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.485674e-01 0.023 0 0
Mitochondrial protein import R-HSA-1268020 9.491679e-01 0.023 0 0
Interferon gamma signaling R-HSA-877300 9.499421e-01 0.022 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.500782e-01 0.022 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.500782e-01 0.022 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.500782e-01 0.022 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.500782e-01 0.022 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.500782e-01 0.022 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.500782e-01 0.022 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.500782e-01 0.022 0 0
Nephron development R-HSA-9831926 9.500782e-01 0.022 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.500782e-01 0.022 0 0
IRE1alpha activates chaperones R-HSA-381070 9.506246e-01 0.022 0 0
Cargo concentration in the ER R-HSA-5694530 9.531557e-01 0.021 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.531557e-01 0.021 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.531557e-01 0.021 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.558011e-01 0.020 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.561820e-01 0.019 0 0
Pyrimidine biosynthesis R-HSA-500753 9.561820e-01 0.019 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.561820e-01 0.019 0 0
Regulation of signaling by CBL R-HSA-912631 9.561820e-01 0.019 0 0
Diseases of hemostasis R-HSA-9671793 9.561820e-01 0.019 0 0
Maturation of nucleoprotein R-HSA-9694631 9.561820e-01 0.019 0 0
Ion transport by P-type ATPases R-HSA-936837 9.568035e-01 0.019 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.575393e-01 0.019 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.579653e-01 0.019 0 0
Protein ubiquitination R-HSA-8852135 9.583313e-01 0.018 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.599540e-01 0.018 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.603732e-01 0.018 0 0
Signaling by FGFR4 R-HSA-5654743 9.614539e-01 0.017 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.614539e-01 0.017 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.615399e-01 0.017 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.615399e-01 0.017 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.615399e-01 0.017 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.615399e-01 0.017 0 0
Negative regulation of MET activity R-HSA-6807004 9.615399e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.615399e-01 0.017 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.622994e-01 0.017 0 0
Surfactant metabolism R-HSA-5683826 9.650272e-01 0.015 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.662024e-01 0.015 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.662024e-01 0.015 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.662429e-01 0.015 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.662429e-01 0.015 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.662429e-01 0.015 0 0
G-protein activation R-HSA-202040 9.662429e-01 0.015 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.662429e-01 0.015 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.662429e-01 0.015 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.662429e-01 0.015 0 0
Phenylalanine metabolism R-HSA-8964208 9.662429e-01 0.015 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.662429e-01 0.015 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.662429e-01 0.015 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.662429e-01 0.015 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.664955e-01 0.015 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.664955e-01 0.015 0 0
HCMV Late Events R-HSA-9610379 9.666344e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.682864e-01 0.014 0 0
Signaling by FGFR3 R-HSA-5654741 9.682864e-01 0.014 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.682864e-01 0.014 0 0
Somitogenesis R-HSA-9824272 9.682864e-01 0.014 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.682864e-01 0.014 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.695548e-01 0.013 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.697150e-01 0.013 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.697150e-01 0.013 0 0
Signal amplification R-HSA-392518 9.697150e-01 0.013 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.697150e-01 0.013 0 0
Signaling by NOTCH2 R-HSA-1980145 9.697150e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.703711e-01 0.013 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.703711e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.703711e-01 0.013 0 0
Assembly Of The HIV Virion R-HSA-175474 9.703711e-01 0.013 0 0
Signaling by FGFR2 R-HSA-5654738 9.718886e-01 0.012 0 0
Dual incision in TC-NER R-HSA-6782135 9.720300e-01 0.012 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.728741e-01 0.012 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.728741e-01 0.012 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.728741e-01 0.012 0 0
Oncogene Induced Senescence R-HSA-2559585 9.728741e-01 0.012 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.739627e-01 0.011 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.739946e-01 0.011 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.739946e-01 0.011 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.739946e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.744645e-01 0.011 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.744645e-01 0.011 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.766990e-01 0.010 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.771752e-01 0.010 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.771752e-01 0.010 0 0
Biosynthesis of maresins R-HSA-9018682 9.771752e-01 0.010 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.771752e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.779361e-01 0.010 0 0
Degradation of DVL R-HSA-4641258 9.782648e-01 0.010 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.782648e-01 0.010 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.782648e-01 0.010 0 0
NCAM1 interactions R-HSA-419037 9.782648e-01 0.010 0 0
DNA Damage Bypass R-HSA-73893 9.786652e-01 0.009 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.787485e-01 0.009 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.796281e-01 0.009 0 0
Complex III assembly R-HSA-9865881 9.799669e-01 0.009 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.799669e-01 0.009 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.799669e-01 0.009 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.799669e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.799669e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.799669e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.799669e-01 0.009 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.799669e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.803505e-01 0.009 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.805553e-01 0.009 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.814569e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.815131e-01 0.008 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.824173e-01 0.008 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.824173e-01 0.008 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.824173e-01 0.008 0 0
Fertilization R-HSA-1187000 9.824173e-01 0.008 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.824173e-01 0.008 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.825511e-01 0.008 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.825511e-01 0.008 0 0
Pentose phosphate pathway R-HSA-71336 9.826108e-01 0.008 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.826108e-01 0.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.826108e-01 0.008 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.830235e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.833518e-01 0.007 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.842305e-01 0.007 0 0
Potential therapeutics for SARS R-HSA-9679191 9.843482e-01 0.007 0 0
Signaling by GPCR R-HSA-372790 9.843837e-01 0.007 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.844546e-01 0.007 0 0
MET activates PTK2 signaling R-HSA-8874081 9.845681e-01 0.007 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.845681e-01 0.007 0 0
Urea cycle R-HSA-70635 9.845681e-01 0.007 0 0
Sphingolipid catabolism R-HSA-9845614 9.845681e-01 0.007 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.857543e-01 0.006 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.861076e-01 0.006 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.861076e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.861647e-01 0.006 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.864559e-01 0.006 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.864559e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.864559e-01 0.006 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.864559e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.866832e-01 0.006 0 0
ABC transporter disorders R-HSA-5619084 9.869739e-01 0.006 0 0
PCP/CE pathway R-HSA-4086400 9.869739e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.869739e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.875870e-01 0.005 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.875890e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9683701 9.875890e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.881129e-01 0.005 0 0
Pyrimidine salvage R-HSA-73614 9.881129e-01 0.005 0 0
Activation of GABAB receptors R-HSA-991365 9.889159e-01 0.005 0 0
GABA B receptor activation R-HSA-977444 9.889159e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.889159e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.889882e-01 0.005 0 0
ABC-family proteins mediated transport R-HSA-382556 9.894461e-01 0.005 0 0
Signaling by FGFR1 R-HSA-5654736 9.895236e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.895673e-01 0.005 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.895673e-01 0.005 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.895673e-01 0.005 0 0
Glucagon-type ligand receptors R-HSA-420092 9.895673e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.905511e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.905511e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.909092e-01 0.004 0 0
Proteasome assembly R-HSA-9907900 9.911675e-01 0.004 0 0
Signaling by Insulin receptor R-HSA-74752 9.912345e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.917429e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.917429e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.917429e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.917451e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.917451e-01 0.004 0 0
Retinoid metabolism and transport R-HSA-975634 9.917451e-01 0.004 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.919641e-01 0.004 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.925070e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.929475e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.929475e-01 0.003 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.929698e-01 0.003 0 0
tRNA Aminoacylation R-HSA-379724 9.930828e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.937305e-01 0.003 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.938105e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.938105e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.939956e-01 0.003 0 0
Leishmania infection R-HSA-9658195 9.940669e-01 0.003 0 0
Parasitic Infection Pathways R-HSA-9824443 9.940669e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.942464e-01 0.003 0 0
Heme degradation R-HSA-189483 9.945680e-01 0.002 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.946221e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.948959e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.952328e-01 0.002 0 0
eNOS activation R-HSA-203615 9.952328e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.952328e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.952328e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.952328e-01 0.002 0 0
Signaling by FGFR R-HSA-190236 9.952508e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.954084e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.958163e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.958163e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.958163e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.958163e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.958412e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.958412e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.960447e-01 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 9.963284e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.963284e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.963284e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.964569e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.965083e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.966980e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.966980e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.967779e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.967779e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.967779e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.967779e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.967779e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.967779e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.968629e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.969160e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.970152e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.970327e-01 0.001 0 0
Protein localization R-HSA-9609507 9.970765e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.971401e-01 0.001 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.971723e-01 0.001 0 0
Purine salvage R-HSA-74217 9.971723e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.972334e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.972687e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.974845e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.975140e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.975185e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.975330e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.976058e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.977060e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.977795e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.978223e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.978503e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.980889e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.981505e-01 0.001 0 0
Neddylation R-HSA-8951664 9.981933e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.983229e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.984427e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.984464e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.984760e-01 0.001 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.985283e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.986065e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.986152e-01 0.001 0 0
Defensins R-HSA-1461973 9.987085e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.987085e-01 0.001 0 0
ER-Phagosome pathway R-HSA-1236974 9.987628e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.987688e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.988667e-01 0.000 0 0
Methylation R-HSA-156581 9.988667e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.988667e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.990055e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.990653e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.992349e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.992798e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.993280e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993942e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.994103e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.994103e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.994103e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994583e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.994847e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.994934e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.995338e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996375e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.996680e-01 0.000 0 0
Translation R-HSA-72766 9.996995e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997036e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997174e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.997308e-01 0.000 0 0
tRNA processing R-HSA-72306 9.997311e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997323e-01 0.000 0 0
Digestion R-HSA-8935690 9.997638e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997925e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998112e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998129e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.998182e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998307e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998405e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998556e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998600e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.998687e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998772e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.998772e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998811e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998897e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999054e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999054e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999119e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999170e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999170e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999170e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999272e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999299e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999299e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999347e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999440e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999668e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999803e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999810e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999863e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999867e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999873e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999910e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999912e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999939e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999959e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999965e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999969e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999976e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999980e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999985e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999986e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999990e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999993e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999996e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999996e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 4.858891e-12 11.313 0 0
Chromatin modifying enzymes R-HSA-3247509 2.347145e-11 10.629 0 0
Apoptotic execution phase R-HSA-75153 2.016462e-09 8.695 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.075484e-09 8.390 0 0
Cell Cycle R-HSA-1640170 1.203054e-08 7.920 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.802939e-08 7.744 0 0
HATs acetylate histones R-HSA-3214847 3.310706e-08 7.480 0 0
mRNA 3'-end processing R-HSA-72187 6.112250e-08 7.214 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.290117e-08 7.081 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.959193e-08 7.099 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.413231e-07 6.850 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.413231e-07 6.850 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.292781e-07 6.888 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.031109e-07 6.518 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.282659e-07 6.484 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.486217e-07 6.261 0 0
Nucleosome assembly R-HSA-774815 5.486217e-07 6.261 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.587399e-07 6.253 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.255332e-07 6.204 0 0
Signal Transduction R-HSA-162582 5.994618e-07 6.222 1 0
DNA methylation R-HSA-5334118 6.490378e-07 6.188 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.685179e-07 6.175 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.495686e-07 6.071 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.030253e-07 6.044 0 0
Cellular Senescence R-HSA-2559583 9.812618e-07 6.008 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.095811e-06 5.960 0 0
Meiotic synapsis R-HSA-1221632 1.221000e-06 5.913 0 0
Cell Cycle, Mitotic R-HSA-69278 1.190355e-06 5.924 0 0
Defective pyroptosis R-HSA-9710421 1.253502e-06 5.902 0 0
Cell Cycle Checkpoints R-HSA-69620 1.374960e-06 5.862 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.470690e-06 5.832 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.777454e-06 5.750 0 0
Mitotic Prophase R-HSA-68875 2.441299e-06 5.612 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.558615e-06 5.592 0 0
DNA Double Strand Break Response R-HSA-5693606 2.631978e-06 5.580 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.258359e-06 5.487 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.758861e-06 5.322 0 0
M Phase R-HSA-68886 4.924078e-06 5.308 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.960429e-06 5.225 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.499716e-06 5.187 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.923328e-06 5.160 0 0
HDACs deacetylate histones R-HSA-3214815 7.022826e-06 5.153 0 0
Packaging Of Telomere Ends R-HSA-171306 7.320461e-06 5.135 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.496818e-06 5.071 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.946374e-06 5.048 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.046273e-05 4.980 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.125414e-05 4.949 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.169076e-05 4.932 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.325767e-05 4.878 0 0
Cellular response to heat stress R-HSA-3371556 1.837084e-05 4.736 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.852281e-05 4.732 0 0
Cell-Cell communication R-HSA-1500931 1.970207e-05 4.705 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.950013e-05 4.710 0 0
Axon guidance R-HSA-422475 2.118949e-05 4.674 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.471134e-05 4.607 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.555554e-05 4.593 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.555554e-05 4.593 0 0
Homology Directed Repair R-HSA-5693538 2.990341e-05 4.524 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.198087e-05 4.495 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.184879e-05 4.497 0 0
HSF1-dependent transactivation R-HSA-3371571 3.283188e-05 4.484 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.381441e-05 4.471 0 0
mRNA Splicing R-HSA-72172 3.689789e-05 4.433 0 0
Cellular responses to stimuli R-HSA-8953897 3.891424e-05 4.410 0 0
Nervous system development R-HSA-9675108 4.468102e-05 4.350 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.854184e-05 4.314 0 0
Cellular responses to stress R-HSA-2262752 4.744591e-05 4.324 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.997602e-05 4.301 0 0
Diseases of programmed cell death R-HSA-9645723 5.050937e-05 4.297 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.581797e-05 4.253 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.602042e-05 4.252 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.473666e-05 4.189 0 0
Meiosis R-HSA-1500620 7.209617e-05 4.142 0 0
Cell junction organization R-HSA-446728 6.958248e-05 4.158 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.856496e-05 4.105 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.085474e-05 4.042 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.243247e-05 4.034 0 0
DAG and IP3 signaling R-HSA-1489509 9.879752e-05 4.005 0 0
Meiotic recombination R-HSA-912446 1.056478e-04 3.976 0 0
G2/M Checkpoints R-HSA-69481 1.070624e-04 3.970 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.111603e-04 3.954 0 0
CaM pathway R-HSA-111997 1.224660e-04 3.912 0 0
Calmodulin induced events R-HSA-111933 1.224660e-04 3.912 0 0
Signaling by ROBO receptors R-HSA-376176 1.241461e-04 3.906 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.285489e-04 3.891 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.528605e-04 3.816 0 0
Cleavage of the damaged purine R-HSA-110331 1.546419e-04 3.811 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.716526e-04 3.765 0 0
Depyrimidination R-HSA-73928 1.716526e-04 3.765 0 0
Signaling by VEGF R-HSA-194138 1.906469e-04 3.720 0 0
Depurination R-HSA-73927 1.938745e-04 3.712 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.162683e-04 3.665 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.413984e-04 3.617 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.537306e-04 3.596 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.726449e-04 3.564 0 0
Attenuation phase R-HSA-3371568 2.986054e-04 3.525 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.289632e-04 3.483 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.387427e-04 3.470 0 0
Metabolism of RNA R-HSA-8953854 3.215650e-04 3.493 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.483635e-04 3.458 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.519440e-04 3.454 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.127822e-04 3.384 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.188965e-04 3.378 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.188965e-04 3.378 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.188965e-04 3.378 0 0
Smooth Muscle Contraction R-HSA-445355 4.592087e-04 3.338 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.185398e-04 3.285 0 0
Ca-dependent events R-HSA-111996 5.448310e-04 3.264 0 0
PLC beta mediated events R-HSA-112043 6.192075e-04 3.208 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.762928e-04 3.170 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.762928e-04 3.170 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.847470e-04 3.164 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.233043e-04 3.141 0 0
Activation of RAC1 R-HSA-428540 8.028876e-04 3.095 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.403193e-04 3.076 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.536114e-04 3.069 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.285475e-04 3.032 0 0
Signaling by ALK in cancer R-HSA-9700206 9.285475e-04 3.032 0 0
Gene Silencing by RNA R-HSA-211000 9.285475e-04 3.032 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.124995e-03 2.949 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.124995e-03 2.949 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.124995e-03 2.949 0 0
RNA Polymerase I Transcription R-HSA-73864 1.098751e-03 2.959 0 0
Signaling by RAS mutants R-HSA-6802949 1.124995e-03 2.949 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.098751e-03 2.959 0 0
Muscle contraction R-HSA-397014 1.036429e-03 2.984 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.134839e-03 2.945 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.135186e-03 2.945 0 0
ESR-mediated signaling R-HSA-8939211 1.156781e-03 2.937 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.164446e-03 2.934 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.164446e-03 2.934 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.290526e-03 2.889 0 0
Deubiquitination R-HSA-5688426 1.340870e-03 2.873 0 0
HSF1 activation R-HSA-3371511 1.350567e-03 2.869 0 0
G-protein mediated events R-HSA-112040 1.498250e-03 2.824 0 0
Reproduction R-HSA-1474165 1.604414e-03 2.795 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.494337e-03 2.826 0 0
Amyloid fiber formation R-HSA-977225 1.612161e-03 2.793 0 0
Adherens junctions interactions R-HSA-418990 1.618947e-03 2.791 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.633002e-03 2.787 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.823192e-03 2.739 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.937227e-03 2.713 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.937227e-03 2.713 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.259409e-03 2.646 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.315805e-03 2.635 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.444559e-03 2.612 0 0
Rap1 signalling R-HSA-392517 2.877903e-03 2.541 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.915730e-03 2.535 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.915730e-03 2.535 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.082652e-03 2.511 0 0
DNA Repair R-HSA-73894 3.203502e-03 2.494 0 0
Cell-cell junction organization R-HSA-421270 2.972433e-03 2.527 0 0
Gene expression (Transcription) R-HSA-74160 3.388434e-03 2.470 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.668798e-03 2.435 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.846185e-03 2.415 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.863662e-03 2.413 0 0
Chromosome Maintenance R-HSA-73886 4.535036e-03 2.343 0 0
Formation of annular gap junctions R-HSA-196025 4.916121e-03 2.308 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.916121e-03 2.308 0 0
Base Excision Repair R-HSA-73884 5.002567e-03 2.301 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.291793e-03 2.276 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.149810e-03 2.288 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.675856e-03 2.246 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.675856e-03 2.246 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.393391e-03 2.268 0 0
Nuclear RNA decay R-HSA-9930044 5.833611e-03 2.234 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.054419e-03 2.218 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.236726e-03 2.205 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.236726e-03 2.205 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.427956e-03 2.192 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.433098e-03 2.192 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.519499e-03 2.186 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.583427e-03 2.182 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.758595e-03 2.170 0 0
Striated Muscle Contraction R-HSA-390522 6.901349e-03 2.161 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.986641e-03 2.156 0 0
Gap junction degradation R-HSA-190873 7.019995e-03 2.154 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.145123e-03 2.146 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.255943e-03 2.139 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.581257e-03 2.120 0 0
RAF activation R-HSA-5673000 8.114477e-03 2.091 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.288798e-03 2.032 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.899761e-03 2.051 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.899761e-03 2.051 0 0
Autophagy R-HSA-9612973 8.474592e-03 2.072 0 0
Protein ubiquitination R-HSA-8852135 9.074962e-03 2.042 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.328355e-03 2.079 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.614360e-03 2.065 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 9.683137e-03 2.014 0 0
Signaling by WNT R-HSA-195721 1.029338e-02 1.987 1 0
MTOR signalling R-HSA-165159 1.158623e-02 1.936 0 0
Mitotic Anaphase R-HSA-68882 1.161433e-02 1.935 0 0
DCC mediated attractive signaling R-HSA-418885 1.185593e-02 1.926 0 0
Mitotic Prometaphase R-HSA-68877 1.220119e-02 1.914 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.229941e-02 1.910 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.238752e-02 1.907 0 0
IRE1alpha activates chaperones R-HSA-381070 1.238752e-02 1.907 0 0
RNA Polymerase II Transcription R-HSA-73857 1.240339e-02 1.906 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.241577e-02 1.906 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.241577e-02 1.906 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.274940e-02 1.895 0 0
Apoptosis R-HSA-109581 1.275809e-02 1.894 0 0
Membrane Trafficking R-HSA-199991 1.319178e-02 1.880 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.332711e-02 1.875 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.676354e-02 1.776 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.676354e-02 1.776 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.676354e-02 1.776 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.676354e-02 1.776 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.676354e-02 1.776 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.524340e-02 1.817 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.615872e-02 1.792 0 0
Peptide chain elongation R-HSA-156902 1.703823e-02 1.769 0 0
RMTs methylate histone arginines R-HSA-3214858 1.504038e-02 1.823 0 0
Ub-specific processing proteases R-HSA-5689880 1.625504e-02 1.789 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.684393e-02 1.774 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.859333e-02 1.731 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.887734e-02 1.724 0 0
Disorders of Nervous System Development R-HSA-9697154 2.163242e-02 1.665 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.163242e-02 1.665 0 0
Pervasive developmental disorders R-HSA-9005895 2.163242e-02 1.665 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.173944e-02 1.663 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.173944e-02 1.663 0 0
mTORC1-mediated signalling R-HSA-166208 2.176066e-02 1.662 0 0
Telomere Maintenance R-HSA-157579 2.236456e-02 1.650 0 0
HCMV Early Events R-HSA-9609690 2.338347e-02 1.631 0 0
Late endosomal microautophagy R-HSA-9615710 2.360079e-02 1.627 0 0
Type I hemidesmosome assembly R-HSA-446107 2.385520e-02 1.622 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.385520e-02 1.622 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.385520e-02 1.622 0 0
NGF-stimulated transcription R-HSA-9031628 2.419465e-02 1.616 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.419465e-02 1.616 0 0
G alpha (12/13) signalling events R-HSA-416482 2.478547e-02 1.606 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.505931e-02 1.601 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.505931e-02 1.601 0 0
Semaphorin interactions R-HSA-373755 2.505931e-02 1.601 0 0
Macroautophagy R-HSA-1632852 2.531341e-02 1.597 0 0
Programmed Cell Death R-HSA-5357801 2.536387e-02 1.596 0 0
EPH-Ephrin signaling R-HSA-2682334 2.585753e-02 1.587 0 0
HCMV Late Events R-HSA-9610379 2.604421e-02 1.584 0 0
Ion homeostasis R-HSA-5578775 2.612191e-02 1.583 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.710056e-02 1.567 0 0
PKA activation R-HSA-163615 2.710056e-02 1.567 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.710056e-02 1.567 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.216488e-02 1.493 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.135140e-02 1.504 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.338266e-02 1.476 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.999205e-02 1.523 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.142429e-02 1.503 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.187202e-02 1.497 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.129748e-02 1.504 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.793256e-02 1.554 0 0
HCMV Infection R-HSA-9609646 2.807638e-02 1.552 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.247377e-02 1.488 0 0
DNA Replication R-HSA-69306 3.356607e-02 1.474 0 0
Netrin-1 signaling R-HSA-373752 3.456116e-02 1.461 0 0
HDMs demethylate histones R-HSA-3214842 3.480151e-02 1.458 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.508854e-02 1.455 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.539012e-02 1.451 0 0
Centrosome maturation R-HSA-380287 3.708109e-02 1.431 0 0
Opioid Signalling R-HSA-111885 3.754293e-02 1.425 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.754293e-02 1.425 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.780174e-02 1.422 0 0
Nephrin family interactions R-HSA-373753 3.813918e-02 1.419 0 0
Developmental Biology R-HSA-1266738 3.833174e-02 1.416 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.008269e-02 1.397 0 0
Myogenesis R-HSA-525793 4.009607e-02 1.397 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.040218e-02 1.394 0 0
Protein methylation R-HSA-8876725 4.049603e-02 1.393 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.058275e-02 1.392 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.065606e-02 1.391 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.065606e-02 1.391 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.255049e-02 1.371 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.378822e-02 1.359 0 0
Translation initiation complex formation R-HSA-72649 4.466813e-02 1.350 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.475299e-02 1.349 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.475299e-02 1.349 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.475299e-02 1.349 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.559452e-02 1.341 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.846065e-02 1.315 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.846065e-02 1.315 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.939430e-02 1.306 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.939430e-02 1.306 0 0
Nuclear import of Rev protein R-HSA-180746 5.120560e-02 1.291 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.168874e-02 1.287 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.168874e-02 1.287 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.906503e-02 1.229 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.906503e-02 1.229 0 0
Regulation of cortical dendrite branching R-HSA-8985801 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.906503e-02 1.229 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.906503e-02 1.229 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.906503e-02 1.229 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.941794e-02 1.226 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.941794e-02 1.226 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.127098e-02 1.213 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.901442e-02 1.229 0 0
RET signaling R-HSA-8853659 6.371384e-02 1.196 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.547044e-02 1.256 0 0
Post NMDA receptor activation events R-HSA-438064 5.447105e-02 1.264 0 0
MAP2K and MAPK activation R-HSA-5674135 5.476487e-02 1.261 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.480680e-02 1.261 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.710422e-02 1.243 0 0
Platelet calcium homeostasis R-HSA-418360 5.901442e-02 1.229 0 0
Disorders of Developmental Biology R-HSA-9675151 5.728497e-02 1.242 0 0
TBC/RABGAPs R-HSA-8854214 6.660735e-02 1.176 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.574662e-02 1.254 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.919819e-02 1.228 0 0
NRAGE signals death through JNK R-HSA-193648 5.354767e-02 1.271 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.682586e-02 1.175 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.696910e-02 1.174 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.011806e-02 1.154 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.132904e-02 1.147 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.261716e-02 1.139 0 0
Repression of WNT target genes R-HSA-4641265 7.369342e-02 1.133 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.369342e-02 1.133 0 0
Neurexins and neuroligins R-HSA-6794361 7.431380e-02 1.129 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.439283e-02 1.128 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.474555e-02 1.126 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.603336e-02 1.119 0 0
SOS-mediated signalling R-HSA-112412 7.603336e-02 1.119 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.603336e-02 1.119 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.688939e-02 1.114 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.705966e-02 1.113 0 0
Ephrin signaling R-HSA-3928664 7.750518e-02 1.111 0 0
PKA activation in glucagon signalling R-HSA-164378 7.750518e-02 1.111 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.750518e-02 1.111 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.750518e-02 1.111 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.812226e-02 1.107 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.893205e-02 1.103 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.994391e-02 1.097 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.262858e-02 1.083 0 0
Death Receptor Signaling R-HSA-73887 8.580196e-02 1.067 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.644476e-02 1.063 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.659187e-02 1.063 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.982325e-02 1.047 0 0
Sensory processing of sound R-HSA-9659379 9.025250e-02 1.045 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.099667e-02 1.041 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.306699e-02 1.031 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.306699e-02 1.031 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.306699e-02 1.031 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.390454e-02 1.027 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.397728e-02 1.027 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.681666e-02 1.014 0 0
Metalloprotease DUBs R-HSA-5689901 9.693347e-02 1.014 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.693347e-02 1.014 0 0
HIV Life Cycle R-HSA-162587 9.823212e-02 1.008 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.969665e-02 1.001 0 0
Selective autophagy R-HSA-9663891 9.969665e-02 1.001 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.009866e-01 0.996 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.010648e-01 0.995 0 0
Protein hydroxylation R-HSA-9629569 1.010648e-01 0.995 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.019192e-01 0.992 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.019192e-01 0.992 0 0
Eukaryotic Translation Termination R-HSA-72764 1.025156e-01 0.989 0 0
Cellular response to starvation R-HSA-9711097 1.026207e-01 0.989 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.079008e-01 0.967 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.084156e-01 0.965 0 0
Regulation of CDH1 Function R-HSA-9764561 1.096399e-01 0.960 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.096399e-01 0.960 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.109670e-01 0.955 0 0
Regulation of gap junction activity R-HSA-191650 1.173213e-01 0.931 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.173213e-01 0.931 0 0
IRS activation R-HSA-74713 1.501650e-01 0.823 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.501650e-01 0.823 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.144760e-01 0.941 0 0
PI3K/AKT activation R-HSA-198203 1.359433e-01 0.867 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.359433e-01 0.867 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.177573e-01 0.929 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.277621e-01 0.894 0 0
Activation of the pre-replicative complex R-HSA-68962 1.443687e-01 0.841 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.443687e-01 0.841 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.437042e-01 0.843 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.443687e-01 0.841 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.177573e-01 0.929 0 0
DARPP-32 events R-HSA-180024 1.316406e-01 0.881 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.359433e-01 0.867 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.260468e-01 0.899 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.173213e-01 0.931 0 0
Separation of Sister Chromatids R-HSA-2467813 1.315392e-01 0.881 0 0
Signal attenuation R-HSA-74749 1.359433e-01 0.867 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.501650e-01 0.823 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.501650e-01 0.823 0 0
Calcineurin activates NFAT R-HSA-2025928 1.144760e-01 0.941 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.501650e-01 0.823 0 0
Rab regulation of trafficking R-HSA-9007101 1.493330e-01 0.826 0 0
Unwinding of DNA R-HSA-176974 1.144760e-01 0.941 0 0
Kinesins R-HSA-983189 1.347237e-01 0.871 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.421992e-01 0.847 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.359433e-01 0.867 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.359433e-01 0.867 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.194767e-01 0.923 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.421992e-01 0.847 0 0
Selenocysteine synthesis R-HSA-2408557 1.409026e-01 0.851 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.316406e-01 0.881 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.374206e-01 0.862 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.521461e-01 0.818 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.529946e-01 0.815 0 0
tRNA processing in the nucleus R-HSA-6784531 1.529946e-01 0.815 0 0
Viral mRNA Translation R-HSA-192823 1.552596e-01 0.809 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.555537e-01 0.808 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.576343e-01 0.802 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.576343e-01 0.802 0 0
Budding and maturation of HIV virion R-HSA-162588 1.576343e-01 0.802 0 0
Signaling by APC mutants R-HSA-4839744 1.586554e-01 0.800 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.586554e-01 0.800 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.586554e-01 0.800 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.586554e-01 0.800 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.586554e-01 0.800 0 0
Signaling by MET R-HSA-6806834 1.590776e-01 0.798 0 0
Regulation of TP53 Activity R-HSA-5633007 1.599914e-01 0.796 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.627199e-01 0.789 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.632823e-01 0.787 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.656411e-01 0.781 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.677611e-01 0.775 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.678352e-01 0.775 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.678352e-01 0.775 0 0
MAPK family signaling cascades R-HSA-5683057 1.690698e-01 0.772 0 0
Influenza Infection R-HSA-168255 1.693787e-01 0.771 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.696215e-01 0.771 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.699829e-01 0.770 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.699829e-01 0.770 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.703868e-01 0.769 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.706097e-01 0.768 0 0
Deadenylation of mRNA R-HSA-429947 1.730349e-01 0.762 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.750014e-01 0.757 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.774775e-01 0.751 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.774775e-01 0.751 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.774775e-01 0.751 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.774775e-01 0.751 0 0
Generic Transcription Pathway R-HSA-212436 1.780629e-01 0.749 0 0
Nucleotide Excision Repair R-HSA-5696398 1.781871e-01 0.749 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.798938e-01 0.745 0 0
Generation of second messenger molecules R-HSA-202433 1.805277e-01 0.743 0 0
Aggrephagy R-HSA-9646399 1.805277e-01 0.743 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.805277e-01 0.743 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.824215e-01 0.739 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.824215e-01 0.739 0 0
Sodium/Calcium exchangers R-HSA-425561 1.824215e-01 0.739 0 0
Signaling by AXIN mutants R-HSA-4839735 1.824215e-01 0.739 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.540363e-01 0.595 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.540363e-01 0.595 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.540363e-01 0.595 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.540363e-01 0.595 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.540363e-01 0.595 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.540363e-01 0.595 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.540363e-01 0.595 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.845433e-01 0.734 0 0
Cam-PDE 1 activation R-HSA-111957 1.845433e-01 0.734 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.845433e-01 0.734 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.557179e-01 0.592 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.557179e-01 0.592 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.557179e-01 0.592 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.557179e-01 0.592 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.070541e-01 0.684 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.070541e-01 0.684 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.070541e-01 0.684 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.070541e-01 0.684 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.070541e-01 0.684 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.070541e-01 0.684 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.323728e-01 0.634 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.323728e-01 0.634 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.323728e-01 0.634 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.096403e-01 0.679 0 0
cGMP effects R-HSA-418457 2.582057e-01 0.588 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.300283e-01 0.638 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.300283e-01 0.638 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.300283e-01 0.638 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.300283e-01 0.638 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.856592e-01 0.731 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.721044e-01 0.565 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.721044e-01 0.565 0 0
HIV elongation arrest and recovery R-HSA-167287 2.411586e-01 0.618 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.411586e-01 0.618 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.309343e-01 0.637 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.592235e-01 0.586 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.592235e-01 0.586 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.368318e-01 0.626 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.500839e-01 0.602 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.943563e-01 0.711 0 0
Integrin signaling R-HSA-354192 1.856592e-01 0.731 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.721044e-01 0.565 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.061611e-01 0.686 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.639591e-01 0.578 0 0
TGFBR3 expression R-HSA-9839394 1.893373e-01 0.723 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.500839e-01 0.602 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.856592e-01 0.731 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.061611e-01 0.686 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.070541e-01 0.684 0 0
Polo-like kinase mediated events R-HSA-156711 1.898041e-01 0.722 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.061611e-01 0.686 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.845433e-01 0.734 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.096403e-01 0.679 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.154576e-01 0.667 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.845433e-01 0.734 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.650175e-01 0.577 0 0
UCH proteinases R-HSA-5689603 2.045255e-01 0.689 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.592235e-01 0.586 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.620756e-01 0.582 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.540363e-01 0.595 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.540363e-01 0.595 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.540363e-01 0.595 0 0
Signaling by LTK R-HSA-9842663 2.070541e-01 0.684 0 0
Regulation of KIT signaling R-HSA-1433559 2.582057e-01 0.588 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.060177e-01 0.686 0 0
rRNA processing R-HSA-72312 2.717954e-01 0.566 0 0
G2/M Transition R-HSA-69275 2.129095e-01 0.672 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.262503e-01 0.645 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.469091e-01 0.607 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.070541e-01 0.684 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.856592e-01 0.731 0 0
Co-inhibition by PD-1 R-HSA-389948 2.432713e-01 0.614 0 0
Vesicle-mediated transport R-HSA-5653656 2.610353e-01 0.583 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.208373e-01 0.656 0 0
Nef and signal transduction R-HSA-164944 2.198866e-01 0.658 0 0
CHL1 interactions R-HSA-447041 2.557179e-01 0.592 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.003539e-01 0.698 0 0
Mitochondrial biogenesis R-HSA-1592230 2.179114e-01 0.662 0 0
Signaling by NTRKs R-HSA-166520 2.749811e-01 0.561 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.898041e-01 0.722 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.540363e-01 0.595 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.540363e-01 0.595 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.845433e-01 0.734 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.721044e-01 0.565 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.690884e-01 0.570 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.557179e-01 0.592 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.856592e-01 0.731 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.370140e-01 0.625 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.557179e-01 0.592 0 0
RUNX2 regulates bone development R-HSA-8941326 2.467472e-01 0.608 0 0
G1/S-Specific Transcription R-HSA-69205 2.467472e-01 0.608 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.508790e-01 0.601 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.845433e-01 0.734 0 0
Interleukin-7 signaling R-HSA-1266695 1.893373e-01 0.723 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.022913e-01 0.694 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 1.898041e-01 0.722 0 0
Cardiac conduction R-HSA-5576891 2.752726e-01 0.560 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.234732e-01 0.490 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.234732e-01 0.490 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.234732e-01 0.490 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.234732e-01 0.490 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.234732e-01 0.490 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.234732e-01 0.490 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.234732e-01 0.490 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.234732e-01 0.490 0 0
Defective DHDDS causes RP59 R-HSA-4755609 3.234732e-01 0.490 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.864504e-01 0.413 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.864504e-01 0.413 0 0
Axonal growth stimulation R-HSA-209563 3.864504e-01 0.413 0 0
Invadopodia formation R-HSA-8941237 3.864504e-01 0.413 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.916405e-01 0.535 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.916405e-01 0.535 0 0
ARMS-mediated activation R-HSA-170984 3.273272e-01 0.485 0 0
Lipophagy R-HSA-9613354 3.273272e-01 0.485 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.435685e-01 0.353 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.435685e-01 0.353 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.435685e-01 0.353 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.435685e-01 0.353 0 0
Erythropoietin activates RAS R-HSA-9027284 2.843911e-01 0.546 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.843911e-01 0.546 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.843911e-01 0.546 0 0
2-LTR circle formation R-HSA-164843 3.625110e-01 0.441 0 0
Phosphorylation of the APC/C R-HSA-176412 3.107787e-01 0.508 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.107787e-01 0.508 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.969764e-01 0.401 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.953723e-01 0.305 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.953723e-01 0.305 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.953723e-01 0.305 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.953723e-01 0.305 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.953723e-01 0.305 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.775927e-01 0.557 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.153403e-01 0.501 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.305524e-01 0.366 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.788317e-01 0.555 0 0
Long-term potentiation R-HSA-9620244 3.590904e-01 0.445 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.590904e-01 0.445 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.126079e-01 0.505 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.939070e-01 0.532 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.157697e-01 0.381 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.631061e-01 0.334 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.423559e-01 0.266 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.423559e-01 0.266 0 0
PDE3B signalling R-HSA-165160 5.423559e-01 0.266 0 0
PKB-mediated events R-HSA-109703 5.423559e-01 0.266 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.423559e-01 0.266 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.027722e-01 0.395 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.027722e-01 0.395 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.027722e-01 0.395 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.027722e-01 0.395 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.413379e-01 0.355 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.413379e-01 0.355 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.274314e-01 0.485 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.244251e-01 0.372 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.274156e-01 0.485 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.667865e-01 0.331 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.879674e-01 0.312 0 0
HIV Transcription Elongation R-HSA-167169 4.852642e-01 0.314 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.852642e-01 0.314 0 0
Transcription of the HIV genome R-HSA-167172 4.643432e-01 0.333 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.787122e-01 0.320 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.286905e-01 0.277 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.929846e-01 0.307 0 0
Hedgehog 'off' state R-HSA-5610787 5.215800e-01 0.283 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.423559e-01 0.266 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.372304e-01 0.472 0 0
Integration of provirus R-HSA-162592 4.305524e-01 0.366 0 0
Ribosome-associated quality control R-HSA-9948299 3.490709e-01 0.457 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.530456e-01 0.452 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.273272e-01 0.485 0 0
MET promotes cell motility R-HSA-8875878 2.792313e-01 0.554 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.339899e-01 0.476 0 0
Regulation of CDH11 function R-HSA-9762292 3.625110e-01 0.441 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.636200e-01 0.439 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.126079e-01 0.505 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.103023e-01 0.387 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.882227e-01 0.540 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.721469e-01 0.429 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.439189e-01 0.464 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.088602e-01 0.388 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.273272e-01 0.485 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.273272e-01 0.485 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.372304e-01 0.472 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.953723e-01 0.305 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.153403e-01 0.501 0 0
Trafficking of AMPA receptors R-HSA-399719 2.962122e-01 0.528 0 0
NF-kB is activated and signals survival R-HSA-209560 4.305524e-01 0.366 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.423559e-01 0.266 0 0
Gap junction trafficking and regulation R-HSA-157858 3.245532e-01 0.489 0 0
Ca2+ pathway R-HSA-4086398 3.951924e-01 0.403 1 1
Prolonged ERK activation events R-HSA-169893 3.107787e-01 0.508 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.458757e-01 0.351 0 0
MET activates RAS signaling R-HSA-8851805 4.631061e-01 0.334 0 0
Gap junction trafficking R-HSA-190828 3.980174e-01 0.400 0 0
Signaling by WNT in cancer R-HSA-4791275 3.150286e-01 0.502 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.667865e-01 0.331 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.916405e-01 0.535 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.625110e-01 0.441 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.625110e-01 0.441 0 0
Formation of the posterior neural plate R-HSA-9832991 3.969764e-01 0.401 0 0
PTK6 Down-Regulation R-HSA-8849472 4.953723e-01 0.305 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.953723e-01 0.305 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.530456e-01 0.452 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.151572e-01 0.382 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.498943e-01 0.347 0 0
Frs2-mediated activation R-HSA-170968 4.945368e-01 0.306 0 0
TNF signaling R-HSA-75893 4.341451e-01 0.362 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.435685e-01 0.353 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.423559e-01 0.266 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.910662e-01 0.309 0 0
DNA strand elongation R-HSA-69190 5.085193e-01 0.294 0 0
G-protein beta:gamma signalling R-HSA-397795 5.286905e-01 0.277 0 0
Mismatch Repair R-HSA-5358508 3.898337e-01 0.409 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.465780e-01 0.460 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.590904e-01 0.445 0 0
Adipogenesis R-HSA-9843745 3.663064e-01 0.436 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.625110e-01 0.441 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.372304e-01 0.472 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.631061e-01 0.334 0 0
PTEN Regulation R-HSA-6807070 4.564598e-01 0.341 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.273272e-01 0.485 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.458757e-01 0.351 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.670721e-01 0.331 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.916609e-01 0.407 0 0
p75NTR signals via NF-kB R-HSA-193639 5.537606e-01 0.257 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.768713e-01 0.322 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.082560e-01 0.511 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.898337e-01 0.409 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.366614e-01 0.360 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.357679e-01 0.271 0 0
Interleukin-33 signaling R-HSA-9014843 3.234732e-01 0.490 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.234732e-01 0.490 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.864504e-01 0.413 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.864504e-01 0.413 0 0
MET interacts with TNS proteins R-HSA-8875513 3.864504e-01 0.413 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.273272e-01 0.485 0 0
Transmission across Electrical Synapses R-HSA-112307 4.435685e-01 0.353 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.435685e-01 0.353 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.625110e-01 0.441 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.625110e-01 0.441 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.107787e-01 0.508 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.107787e-01 0.508 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.107787e-01 0.508 0 0
Reelin signalling pathway R-HSA-8866376 4.953723e-01 0.305 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.371891e-01 0.472 0 0
Regulation of IFNG signaling R-HSA-877312 4.631061e-01 0.334 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.423559e-01 0.266 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.423559e-01 0.266 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.423559e-01 0.266 0 0
Phosphorylation of Emi1 R-HSA-176417 5.423559e-01 0.266 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.721469e-01 0.429 0 0
Metabolism of non-coding RNA R-HSA-194441 3.336656e-01 0.477 0 0
snRNP Assembly R-HSA-191859 3.336656e-01 0.477 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.945368e-01 0.306 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.292697e-01 0.367 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.151572e-01 0.382 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.916609e-01 0.407 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.910662e-01 0.309 0 0
HIV Infection R-HSA-162906 3.043673e-01 0.517 0 0
Notch-HLH transcription pathway R-HSA-350054 5.150998e-01 0.288 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.537606e-01 0.257 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.111470e-01 0.291 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.339899e-01 0.476 0 0
Signaling by TGFBR3 R-HSA-9839373 2.788317e-01 0.555 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.211769e-01 0.283 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.151572e-01 0.382 0 0
Pexophagy R-HSA-9664873 3.625110e-01 0.441 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.035117e-01 0.298 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.157697e-01 0.381 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.537606e-01 0.257 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.355727e-01 0.474 0 0
TRP channels R-HSA-3295583 3.809735e-01 0.419 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.247715e-01 0.280 0 0
Regulation of insulin secretion R-HSA-422356 3.785923e-01 0.422 0 0
Integration of energy metabolism R-HSA-163685 3.301788e-01 0.481 0 0
Neuronal System R-HSA-112316 5.064744e-01 0.295 0 0
Neurodegenerative Diseases R-HSA-8863678 3.371891e-01 0.472 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.371891e-01 0.472 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.273272e-01 0.485 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.273272e-01 0.485 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.273272e-01 0.485 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.423559e-01 0.266 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.481102e-01 0.349 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.247715e-01 0.280 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.247715e-01 0.280 0 0
Heme signaling R-HSA-9707616 5.261383e-01 0.279 0 0
Signaling by PTK6 R-HSA-8848021 3.916609e-01 0.407 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.916609e-01 0.407 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.027722e-01 0.395 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.026231e-01 0.519 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.035117e-01 0.298 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.465780e-01 0.460 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.864504e-01 0.413 0 0
Sensory perception of sour taste R-HSA-9729555 4.435685e-01 0.353 0 0
Josephin domain DUBs R-HSA-5689877 3.625110e-01 0.441 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.107787e-01 0.508 0 0
Interleukin-36 pathway R-HSA-9014826 4.953723e-01 0.305 0 0
Signaling by Hippo R-HSA-2028269 3.636200e-01 0.439 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.305524e-01 0.366 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.305524e-01 0.366 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.339899e-01 0.476 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.423559e-01 0.266 0 0
Negative regulation of MET activity R-HSA-6807004 4.413379e-01 0.355 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.664595e-01 0.331 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.484476e-01 0.261 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.339899e-01 0.476 0 0
Glycolysis R-HSA-70171 2.938073e-01 0.532 0 0
Carnitine shuttle R-HSA-200425 5.385116e-01 0.269 0 0
Cardiogenesis R-HSA-9733709 5.286905e-01 0.277 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.980174e-01 0.400 0 0
DNA Damage Bypass R-HSA-73893 3.245532e-01 0.489 0 0
FLT3 signaling in disease R-HSA-9682385 4.103023e-01 0.387 0 0
Histamine receptors R-HSA-390650 3.864504e-01 0.413 0 0
Suppression of apoptosis R-HSA-9635465 3.969764e-01 0.401 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.912473e-01 0.408 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.537606e-01 0.257 0 0
The NLRP3 inflammasome R-HSA-844456 4.157697e-01 0.381 0 0
L1CAM interactions R-HSA-373760 2.939936e-01 0.532 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.341451e-01 0.362 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.815403e-01 0.418 0 0
Diseases of DNA repair R-HSA-9675135 4.322407e-01 0.364 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.856423e-01 0.314 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.286905e-01 0.277 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.843911e-01 0.546 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.625110e-01 0.441 0 0
NrCAM interactions R-HSA-447038 4.953723e-01 0.305 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.305524e-01 0.366 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.295372e-01 0.482 0 0
Estrogen biosynthesis R-HSA-193144 4.631061e-01 0.334 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.631061e-01 0.334 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.423559e-01 0.266 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.965407e-01 0.528 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.670721e-01 0.331 0 0
Downstream signal transduction R-HSA-186763 4.879674e-01 0.312 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.035117e-01 0.298 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.385116e-01 0.269 0 0
Signaling by NOTCH R-HSA-157118 3.274399e-01 0.485 0 0
Viral Infection Pathways R-HSA-9824446 4.803855e-01 0.318 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.495323e-01 0.347 0 0
Biotin transport and metabolism R-HSA-196780 5.537606e-01 0.257 0 0
PKR-mediated signaling R-HSA-9833482 3.594028e-01 0.444 0 0
Glucose metabolism R-HSA-70326 5.147272e-01 0.288 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.461270e-01 0.263 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.245532e-01 0.489 0 0
Maturation of nucleoprotein R-HSA-9683610 4.945368e-01 0.306 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.286905e-01 0.277 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.273272e-01 0.485 0 0
Signaling by FGFR in disease R-HSA-1226099 5.488021e-01 0.261 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.273272e-01 0.485 0 0
Interleukin-1 processing R-HSA-448706 3.273272e-01 0.485 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.843911e-01 0.546 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.969764e-01 0.401 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 4.953723e-01 0.305 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.423559e-01 0.266 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.322407e-01 0.364 0 0
Formation of the anterior neural plate R-HSA-9823739 5.537606e-01 0.257 0 0
Syndecan interactions R-HSA-3000170 5.385116e-01 0.269 0 0
Stimuli-sensing channels R-HSA-2672351 5.065892e-01 0.295 0 0
Metal ion SLC transporters R-HSA-425410 4.661221e-01 0.332 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.320105e-01 0.274 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.843911e-01 0.546 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.945368e-01 0.306 0 0
Specification of primordial germ cells R-HSA-9827857 3.636200e-01 0.439 0 0
Regulation of beta-cell development R-HSA-186712 3.336656e-01 0.477 0 0
Zinc transporters R-HSA-435354 5.247715e-01 0.280 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.953723e-01 0.305 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.305524e-01 0.366 0 0
Growth hormone receptor signaling R-HSA-982772 5.385116e-01 0.269 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 3.193602e-01 0.496 0 0
HDL assembly R-HSA-8963896 5.247715e-01 0.280 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.208279e-01 0.376 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.320105e-01 0.274 0 0
Signaling by Leptin R-HSA-2586552 3.625110e-01 0.441 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.157697e-01 0.381 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.945368e-01 0.306 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.247715e-01 0.280 0 0
Interleukin-37 signaling R-HSA-9008059 4.670721e-01 0.331 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.936190e-01 0.532 0 0
S Phase R-HSA-69242 5.550987e-01 0.256 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.612612e-01 0.251 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.612612e-01 0.251 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.612612e-01 0.251 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.612612e-01 0.251 0 0
Cilium Assembly R-HSA-5617833 5.670599e-01 0.246 0 0
Dual Incision in GG-NER R-HSA-5696400 5.677620e-01 0.246 0 0
Mitophagy R-HSA-5205647 5.677620e-01 0.246 0 0
Signaling by NOTCH2 R-HSA-1980145 5.677620e-01 0.246 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.677620e-01 0.246 0 0
Leishmania phagocytosis R-HSA-9664417 5.690305e-01 0.245 0 0
Parasite infection R-HSA-9664407 5.690305e-01 0.245 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.690305e-01 0.245 0 0
Signaling by TGFB family members R-HSA-9006936 5.698415e-01 0.244 0 0
Signaling by NOTCH1 R-HSA-1980143 5.757558e-01 0.240 0 0
Interleukin-12 signaling R-HSA-9020591 5.757558e-01 0.240 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.814738e-01 0.235 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.814738e-01 0.235 0 0
Tight junction interactions R-HSA-420029 5.833165e-01 0.234 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.849676e-01 0.233 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.849676e-01 0.233 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.849676e-01 0.233 0 0
CREB phosphorylation R-HSA-199920 5.849676e-01 0.233 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.849676e-01 0.233 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.849676e-01 0.233 0 0
Neurofascin interactions R-HSA-447043 5.849676e-01 0.233 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.849676e-01 0.233 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.849676e-01 0.233 0 0
NADPH regeneration R-HSA-389542 5.849676e-01 0.233 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.849676e-01 0.233 0 0
Lipid particle organization R-HSA-8964572 5.849676e-01 0.233 0 0
Signalling to ERKs R-HSA-187687 5.866088e-01 0.232 0 0
Oncogene Induced Senescence R-HSA-2559585 5.866088e-01 0.232 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.866088e-01 0.232 0 0
Host Interactions of HIV factors R-HSA-162909 5.892734e-01 0.230 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.942474e-01 0.226 0 0
Signaling by EGFR R-HSA-177929 5.942474e-01 0.226 0 0
Platelet homeostasis R-HSA-418346 6.019096e-01 0.220 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.019468e-01 0.220 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.046527e-01 0.218 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.046527e-01 0.218 0 0
Triglyceride catabolism R-HSA-163560 6.049674e-01 0.218 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.049674e-01 0.218 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.067065e-01 0.217 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.078974e-01 0.216 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.078974e-01 0.216 0 0
Coenzyme A biosynthesis R-HSA-196783 6.078974e-01 0.216 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.078974e-01 0.216 0 0
Synthesis of PG R-HSA-1483148 6.078974e-01 0.216 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.078974e-01 0.216 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.228205e-01 0.206 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.236140e-01 0.205 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.236140e-01 0.205 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.236140e-01 0.205 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.236140e-01 0.205 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.236140e-01 0.205 0 0
Disinhibition of SNARE formation R-HSA-114516 6.236140e-01 0.205 0 0
Recycling of eIF2:GDP R-HSA-72731 6.236140e-01 0.205 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.236140e-01 0.205 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.236140e-01 0.205 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.236140e-01 0.205 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.236140e-01 0.205 0 0
VLDL clearance R-HSA-8964046 6.236140e-01 0.205 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.236140e-01 0.205 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.236140e-01 0.205 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.236140e-01 0.205 0 0
Regulation of PTEN localization R-HSA-8948747 6.236140e-01 0.205 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.236140e-01 0.205 0 0
Cristae formation R-HSA-8949613 6.252513e-01 0.204 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.252513e-01 0.204 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.252513e-01 0.204 0 0
Leishmania infection R-HSA-9658195 6.284474e-01 0.202 0 0
Parasitic Infection Pathways R-HSA-9824443 6.284474e-01 0.202 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.330314e-01 0.199 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.330314e-01 0.199 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.330314e-01 0.199 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.330314e-01 0.199 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.330314e-01 0.199 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.330314e-01 0.199 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.330314e-01 0.199 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.379022e-01 0.195 0 0
GPER1 signaling R-HSA-9634597 6.382355e-01 0.195 0 0
Co-stimulation by CD28 R-HSA-389356 6.382355e-01 0.195 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.401544e-01 0.194 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.418424e-01 0.193 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.443490e-01 0.191 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.451003e-01 0.190 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.451003e-01 0.190 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.451003e-01 0.190 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.451003e-01 0.190 0 0
Inflammasomes R-HSA-622312 6.451003e-01 0.190 0 0
Pyroptosis R-HSA-5620971 6.451003e-01 0.190 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.512967e-01 0.186 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.514076e-01 0.186 0 0
Signaling by ERBB2 R-HSA-1227986 6.518163e-01 0.186 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.518163e-01 0.186 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.518163e-01 0.186 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.518163e-01 0.186 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.518163e-01 0.186 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.518163e-01 0.186 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.526780e-01 0.185 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.568866e-01 0.183 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.568866e-01 0.183 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.568866e-01 0.183 0 0
Nephron development R-HSA-9831926 6.568866e-01 0.183 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.568866e-01 0.183 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.578978e-01 0.182 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.586638e-01 0.181 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.586638e-01 0.181 0 0
MET receptor recycling R-HSA-8875656 6.586638e-01 0.181 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.586638e-01 0.181 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.586638e-01 0.181 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.586638e-01 0.181 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.586638e-01 0.181 0 0
Regulation by c-FLIP R-HSA-3371378 6.586638e-01 0.181 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.586638e-01 0.181 0 0
Fructose biosynthesis R-HSA-5652227 6.586638e-01 0.181 0 0
Dimerization of procaspase-8 R-HSA-69416 6.586638e-01 0.181 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.586638e-01 0.181 0 0
Adrenoceptors R-HSA-390696 6.586638e-01 0.181 0 0
Sodium/Proton exchangers R-HSA-425986 6.586638e-01 0.181 0 0
Alpha-defensins R-HSA-1462054 6.586638e-01 0.181 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.640502e-01 0.178 0 0
Signaling by Erythropoietin R-HSA-9006335 6.641925e-01 0.178 0 0
mRNA Capping R-HSA-72086 6.641925e-01 0.178 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.641925e-01 0.178 0 0
Aquaporin-mediated transport R-HSA-445717 6.653979e-01 0.177 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.664103e-01 0.176 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.732258e-01 0.172 0 0
Neutrophil degranulation R-HSA-6798695 6.758365e-01 0.170 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.764087e-01 0.170 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.794834e-01 0.168 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.794834e-01 0.168 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.794834e-01 0.168 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.794834e-01 0.168 0 0
Maturation of nucleoprotein R-HSA-9694631 6.794834e-01 0.168 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.794834e-01 0.168 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.825260e-01 0.166 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.825260e-01 0.166 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.825260e-01 0.166 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.825260e-01 0.166 0 0
MHC class II antigen presentation R-HSA-2132295 6.854596e-01 0.164 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.866091e-01 0.163 0 0
CASP8 activity is inhibited R-HSA-5218900 6.904516e-01 0.161 0 0
ALK mutants bind TKIs R-HSA-9700645 6.904516e-01 0.161 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.904516e-01 0.161 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.904516e-01 0.161 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.904516e-01 0.161 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.904516e-01 0.161 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.904516e-01 0.161 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.904516e-01 0.161 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.904516e-01 0.161 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.904516e-01 0.161 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.904516e-01 0.161 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.904516e-01 0.161 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.904516e-01 0.161 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.949547e-01 0.158 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.954318e-01 0.158 0 0
Orc1 removal from chromatin R-HSA-68949 6.963964e-01 0.157 0 0
Selenoamino acid metabolism R-HSA-2408522 6.969053e-01 0.157 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.001029e-01 0.155 0 0
EGFR downregulation R-HSA-182971 7.001029e-01 0.155 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.002546e-01 0.155 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.008491e-01 0.154 0 0
Formation of definitive endoderm R-HSA-9823730 7.008491e-01 0.154 0 0
Signaling by NODAL R-HSA-1181150 7.008491e-01 0.154 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.041320e-01 0.152 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.041320e-01 0.152 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.098822e-01 0.149 0 0
G1/S Transition R-HSA-69206 7.127131e-01 0.147 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.165658e-01 0.145 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.169289e-01 0.145 0 0
G0 and Early G1 R-HSA-1538133 7.169289e-01 0.145 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.169289e-01 0.145 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.187689e-01 0.143 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.187689e-01 0.143 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.192025e-01 0.143 0 0
Interleukin-12 family signaling R-HSA-447115 7.192025e-01 0.143 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.192808e-01 0.143 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.192808e-01 0.143 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.192808e-01 0.143 0 0
DNA replication initiation R-HSA-68952 7.192808e-01 0.143 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.192808e-01 0.143 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.192808e-01 0.143 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.192808e-01 0.143 0 0
Sperm Motility And Taxes R-HSA-1300642 7.192808e-01 0.143 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.192808e-01 0.143 0 0
Formation of apoptosome R-HSA-111458 7.192808e-01 0.143 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.210171e-01 0.142 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.210171e-01 0.142 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.210171e-01 0.142 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.210171e-01 0.142 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.210171e-01 0.142 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.210171e-01 0.142 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.210171e-01 0.142 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.229410e-01 0.141 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.264412e-01 0.139 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.284629e-01 0.138 0 0
Platelet degranulation R-HSA-114608 7.300372e-01 0.137 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.330132e-01 0.135 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.334324e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.400251e-01 0.131 0 0
Attachment and Entry R-HSA-9694614 7.400251e-01 0.131 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.400251e-01 0.131 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.400251e-01 0.131 0 0
Assembly Of The HIV Virion R-HSA-175474 7.400251e-01 0.131 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.454266e-01 0.128 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.454266e-01 0.128 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.454266e-01 0.128 0 0
LGI-ADAM interactions R-HSA-5682910 7.454266e-01 0.128 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.454266e-01 0.128 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.454266e-01 0.128 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.454266e-01 0.128 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.454266e-01 0.128 0 0
vRNP Assembly R-HSA-192905 7.454266e-01 0.128 0 0
Synthesis of PI R-HSA-1483226 7.454266e-01 0.128 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.454266e-01 0.128 0 0
Bicarbonate transporters R-HSA-425381 7.454266e-01 0.128 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.454266e-01 0.128 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.454266e-01 0.128 0 0
G1 Phase R-HSA-69236 7.464208e-01 0.127 0 0
Cyclin D associated events in G1 R-HSA-69231 7.464208e-01 0.127 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.483675e-01 0.126 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.483675e-01 0.126 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.486916e-01 0.126 0 0
TCR signaling R-HSA-202403 7.513069e-01 0.124 0 0
FGFR2 alternative splicing R-HSA-6803529 7.579141e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.579141e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.579141e-01 0.120 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.579141e-01 0.120 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.579141e-01 0.120 0 0
eNOS activation R-HSA-203615 7.630063e-01 0.117 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.630063e-01 0.117 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.630063e-01 0.117 0 0
Inositol phosphate metabolism R-HSA-1483249 7.683428e-01 0.114 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.691386e-01 0.114 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.691386e-01 0.114 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.691386e-01 0.114 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.691386e-01 0.114 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.691386e-01 0.114 0 0
Anchoring fibril formation R-HSA-2214320 7.691386e-01 0.114 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.691386e-01 0.114 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 7.691386e-01 0.114 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.691386e-01 0.114 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.747276e-01 0.111 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.747276e-01 0.111 0 0
Protein folding R-HSA-391251 7.773520e-01 0.109 0 0
SARS-CoV Infections R-HSA-9679506 7.807673e-01 0.107 0 0
Triglyceride metabolism R-HSA-8979227 7.818782e-01 0.107 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.839284e-01 0.106 0 0
Recycling pathway of L1 R-HSA-437239 7.839284e-01 0.106 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.890635e-01 0.103 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.902035e-01 0.102 0 0
RNA Polymerase III Transcription R-HSA-74158 7.902035e-01 0.102 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.902035e-01 0.102 0 0
GPVI-mediated activation cascade R-HSA-114604 7.902035e-01 0.102 0 0
Glycosphingolipid transport R-HSA-9845576 7.902035e-01 0.102 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.905108e-01 0.102 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.905108e-01 0.102 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.906433e-01 0.102 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.906433e-01 0.102 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.906433e-01 0.102 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.906433e-01 0.102 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.906433e-01 0.102 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.906433e-01 0.102 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.906433e-01 0.102 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.906433e-01 0.102 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.906433e-01 0.102 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.906433e-01 0.102 0 0
Polymerase switching R-HSA-69091 7.906433e-01 0.102 0 0
Leading Strand Synthesis R-HSA-69109 7.906433e-01 0.102 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.906433e-01 0.102 0 0
OAS antiviral response R-HSA-8983711 7.906433e-01 0.102 0 0
Interleukin-15 signaling R-HSA-8983432 7.906433e-01 0.102 0 0
tRNA Aminoacylation R-HSA-379724 7.924191e-01 0.101 0 0
RSV-host interactions R-HSA-9833110 7.970830e-01 0.098 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.025573e-01 0.096 0 0
Collagen degradation R-HSA-1442490 8.025573e-01 0.096 0 0
MAP kinase activation R-HSA-450294 8.025573e-01 0.096 0 0
Collagen chain trimerization R-HSA-8948216 8.027991e-01 0.095 0 0
Laminin interactions R-HSA-3000157 8.053097e-01 0.094 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.053097e-01 0.094 0 0
Formation of the nephric duct R-HSA-9830364 8.053097e-01 0.094 0 0
Degradation of CDH1 R-HSA-9766229 8.063848e-01 0.093 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.063848e-01 0.093 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.063848e-01 0.093 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.067291e-01 0.093 0 0
Transmission across Chemical Synapses R-HSA-112315 8.073266e-01 0.093 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.101459e-01 0.091 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.101459e-01 0.091 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.101459e-01 0.091 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.101459e-01 0.091 0 0
Processing of SMDT1 R-HSA-8949664 8.101459e-01 0.091 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.101459e-01 0.091 0 0
Chylomicron remodeling R-HSA-8963901 8.101459e-01 0.091 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.101459e-01 0.091 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.101459e-01 0.091 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.101459e-01 0.091 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.101459e-01 0.091 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.101459e-01 0.091 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.101459e-01 0.091 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.101459e-01 0.091 0 0
Signaling by NOTCH4 R-HSA-9013694 8.103846e-01 0.091 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.122998e-01 0.090 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.122998e-01 0.090 0 0
Signaling by PDGF R-HSA-186797 8.122998e-01 0.090 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.147529e-01 0.089 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.168803e-01 0.088 0 0
MET activates PTK2 signaling R-HSA-8874081 8.191706e-01 0.087 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.191706e-01 0.087 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.191706e-01 0.087 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.191706e-01 0.087 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.191706e-01 0.087 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.191706e-01 0.087 0 0
Synthesis of DNA R-HSA-69239 8.197808e-01 0.086 0 0
tRNA processing R-HSA-72306 8.221913e-01 0.085 0 0
Signaling by Hedgehog R-HSA-5358351 8.256945e-01 0.083 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.260861e-01 0.083 0 0
Signaling by ALK R-HSA-201556 8.260861e-01 0.083 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.260861e-01 0.083 0 0
Removal of the Flap Intermediate R-HSA-69166 8.278328e-01 0.082 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.278328e-01 0.082 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.278328e-01 0.082 0 0
Physiological factors R-HSA-5578768 8.278328e-01 0.082 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.278328e-01 0.082 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.278328e-01 0.082 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.278328e-01 0.082 0 0
Signal regulatory protein family interactions R-HSA-391160 8.278328e-01 0.082 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.278741e-01 0.082 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.281807e-01 0.082 0 0
IGF1R signaling cascade R-HSA-2428924 8.306285e-01 0.081 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.306285e-01 0.081 0 0
Ion transport by P-type ATPases R-HSA-936837 8.306285e-01 0.081 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.321398e-01 0.080 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.321398e-01 0.080 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.321398e-01 0.080 0 0
Potential therapeutics for SARS R-HSA-9679191 8.340398e-01 0.079 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.356918e-01 0.078 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.364668e-01 0.078 0 0
Glycogen metabolism R-HSA-8982491 8.368204e-01 0.077 0 0
Diseases of Immune System R-HSA-5260271 8.368204e-01 0.077 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.368204e-01 0.077 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.392317e-01 0.076 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.438730e-01 0.074 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.438730e-01 0.074 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.438730e-01 0.074 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.438730e-01 0.074 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.438730e-01 0.074 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.438730e-01 0.074 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.438730e-01 0.074 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.438730e-01 0.074 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.438730e-01 0.074 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.438730e-01 0.074 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.438730e-01 0.074 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.438730e-01 0.074 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.438730e-01 0.074 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.442631e-01 0.074 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.455839e-01 0.073 0 0
FLT3 Signaling R-HSA-9607240 8.469779e-01 0.072 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.538353e-01 0.069 0 0
Circadian clock R-HSA-9909396 8.538670e-01 0.069 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.555856e-01 0.068 0 0
Glucagon-type ligand receptors R-HSA-420092 8.555856e-01 0.068 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.565812e-01 0.067 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.565812e-01 0.067 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.565812e-01 0.067 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.584196e-01 0.066 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.584196e-01 0.066 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.584196e-01 0.066 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.584196e-01 0.066 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.584196e-01 0.066 0 0
Killing mechanisms R-HSA-9664420 8.584196e-01 0.066 0 0
Activation of SMO R-HSA-5635838 8.584196e-01 0.066 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.584196e-01 0.066 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.584196e-01 0.066 0 0
Attachment and Entry R-HSA-9678110 8.584196e-01 0.066 0 0
Atorvastatin ADME R-HSA-9754706 8.584196e-01 0.066 0 0
Negative regulation of FLT3 R-HSA-9706369 8.584196e-01 0.066 0 0
Ion channel transport R-HSA-983712 8.609180e-01 0.065 0 0
PPARA activates gene expression R-HSA-1989781 8.611980e-01 0.065 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.625340e-01 0.064 0 0
Regulated Necrosis R-HSA-5218859 8.629054e-01 0.064 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.656527e-01 0.063 0 0
DAP12 signaling R-HSA-2424491 8.661511e-01 0.062 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.661511e-01 0.062 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.661511e-01 0.062 0 0
Signaling by FGFR1 R-HSA-5654736 8.703950e-01 0.060 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.716117e-01 0.060 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.716117e-01 0.060 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.716117e-01 0.060 0 0
Phase 2 - plateau phase R-HSA-5576893 8.716117e-01 0.060 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.716117e-01 0.060 0 0
Passive transport by Aquaporins R-HSA-432047 8.716117e-01 0.060 0 0
Fibronectin matrix formation R-HSA-1566977 8.716117e-01 0.060 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.716117e-01 0.060 0 0
Galactose catabolism R-HSA-70370 8.716117e-01 0.060 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.716117e-01 0.060 0 0
Signaling by SCF-KIT R-HSA-1433557 8.742147e-01 0.058 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.744844e-01 0.058 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.760024e-01 0.057 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.762641e-01 0.057 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.770047e-01 0.057 0 0
Interleukin-17 signaling R-HSA-448424 8.770047e-01 0.057 0 0
IRS-mediated signalling R-HSA-112399 8.778656e-01 0.057 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.781160e-01 0.056 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.800333e-01 0.056 1 0
Collagen formation R-HSA-1474290 8.803712e-01 0.055 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.833019e-01 0.054 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.835752e-01 0.054 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.835752e-01 0.054 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.835752e-01 0.054 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.835752e-01 0.054 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.835752e-01 0.054 0 0
Glycogen storage diseases R-HSA-3229121 8.835752e-01 0.054 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.835752e-01 0.054 0 0
Hedgehog 'on' state R-HSA-5632684 8.835793e-01 0.054 0 0
Metabolism of cofactors R-HSA-8978934 8.835793e-01 0.054 0 0
Dual incision in TC-NER R-HSA-6782135 8.849600e-01 0.053 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.849600e-01 0.053 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.898992e-01 0.051 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.937261e-01 0.049 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.937261e-01 0.049 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.944246e-01 0.048 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.944246e-01 0.048 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.944246e-01 0.048 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.944246e-01 0.048 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.944246e-01 0.048 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.944246e-01 0.048 0 0
Apoptotic factor-mediated response R-HSA-111471 8.944246e-01 0.048 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.944246e-01 0.048 0 0
Tie2 Signaling R-HSA-210993 8.944246e-01 0.048 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.944246e-01 0.048 0 0
Platelet sensitization by LDL R-HSA-432142 8.944246e-01 0.048 0 0
GAB1 signalosome R-HSA-180292 8.944246e-01 0.048 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.970650e-01 0.047 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.970650e-01 0.047 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.970650e-01 0.047 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.970650e-01 0.047 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.009586e-01 0.045 0 0
Signaling by ERBB4 R-HSA-1236394 9.015243e-01 0.045 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.016766e-01 0.045 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.016766e-01 0.045 0 0
Adaptive Immune System R-HSA-1280218 9.033631e-01 0.044 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.042636e-01 0.044 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.042636e-01 0.044 0 0
Pyrimidine biosynthesis R-HSA-500753 9.042636e-01 0.044 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.042636e-01 0.044 0 0
Translesion Synthesis by POLH R-HSA-110320 9.042636e-01 0.044 0 0
Diseases of hemostasis R-HSA-9671793 9.042636e-01 0.044 0 0
Regulation of signaling by CBL R-HSA-912631 9.042636e-01 0.044 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.042636e-01 0.044 0 0
Other interleukin signaling R-HSA-449836 9.042636e-01 0.044 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.064500e-01 0.043 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.064500e-01 0.043 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.064500e-01 0.043 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.076683e-01 0.042 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.076683e-01 0.042 0 0
Gap junction assembly R-HSA-190861 9.090689e-01 0.041 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.090689e-01 0.041 0 0
Mitochondrial protein import R-HSA-1268020 9.098576e-01 0.041 0 0
Gluconeogenesis R-HSA-70263 9.101496e-01 0.041 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.131862e-01 0.039 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.131862e-01 0.039 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.131862e-01 0.039 0 0
Glycogen synthesis R-HSA-3322077 9.131862e-01 0.039 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.131862e-01 0.039 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.131862e-01 0.039 0 0
Pregnenolone biosynthesis R-HSA-196108 9.131862e-01 0.039 0 0
Signal transduction by L1 R-HSA-445144 9.131862e-01 0.039 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.152813e-01 0.038 0 0
PERK regulates gene expression R-HSA-381042 9.159380e-01 0.038 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.159380e-01 0.038 0 0
Interleukin-1 signaling R-HSA-9020702 9.196362e-01 0.036 0 0
Neurotransmitter release cycle R-HSA-112310 9.200225e-01 0.036 0 0
Insulin receptor signalling cascade R-HSA-74751 9.204115e-01 0.036 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.212776e-01 0.036 0 0
Lagging Strand Synthesis R-HSA-69186 9.212776e-01 0.036 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.212776e-01 0.036 0 0
Signalling to RAS R-HSA-167044 9.212776e-01 0.036 0 0
Phenylalanine metabolism R-HSA-8964208 9.212776e-01 0.036 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.212776e-01 0.036 0 0
Basigin interactions R-HSA-210991 9.212776e-01 0.036 0 0
PI3K Cascade R-HSA-109704 9.217059e-01 0.035 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.217059e-01 0.035 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.223171e-01 0.035 0 0
Hemostasis R-HSA-109582 9.225990e-01 0.035 0 0
PI Metabolism R-HSA-1483255 9.236585e-01 0.034 0 0
The phototransduction cascade R-HSA-2514856 9.269592e-01 0.033 0 0
Voltage gated Potassium channels R-HSA-1296072 9.282379e-01 0.032 0 0
NCAM1 interactions R-HSA-419037 9.282379e-01 0.032 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.286154e-01 0.032 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.286154e-01 0.032 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.286154e-01 0.032 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.286154e-01 0.032 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.298436e-01 0.032 0 0
Translation R-HSA-72766 9.301935e-01 0.031 0 0
Interferon Signaling R-HSA-913531 9.302375e-01 0.031 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.310687e-01 0.031 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.315521e-01 0.031 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.337304e-01 0.030 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.337304e-01 0.030 0 0
Kidney development R-HSA-9830369 9.341705e-01 0.030 0 0
Neddylation R-HSA-8951664 9.343605e-01 0.029 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.352695e-01 0.029 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.352695e-01 0.029 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.352695e-01 0.029 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.352695e-01 0.029 0 0
Fructose metabolism R-HSA-5652084 9.352695e-01 0.029 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.352695e-01 0.029 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.352695e-01 0.029 0 0
Signaling by KIT in disease R-HSA-9669938 9.352695e-01 0.029 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.352695e-01 0.029 0 0
LDL clearance R-HSA-8964038 9.352695e-01 0.029 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.382540e-01 0.028 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.393242e-01 0.027 0 0
Extracellular matrix organization R-HSA-1474244 9.405639e-01 0.027 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.413038e-01 0.026 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.413038e-01 0.026 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.413038e-01 0.026 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.413038e-01 0.026 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.413038e-01 0.026 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.413038e-01 0.026 0 0
Formation of the ureteric bud R-HSA-9830674 9.413038e-01 0.026 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.413038e-01 0.026 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.413038e-01 0.026 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.413038e-01 0.026 0 0
Interleukin-1 family signaling R-HSA-446652 9.419937e-01 0.026 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.425959e-01 0.026 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.435422e-01 0.025 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.435422e-01 0.025 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.435422e-01 0.025 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.435422e-01 0.025 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.446699e-01 0.025 0 0
G alpha (z) signalling events R-HSA-418597 9.448897e-01 0.025 0 0
Signaling by NOTCH3 R-HSA-9012852 9.448897e-01 0.025 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.464431e-01 0.024 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.464431e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.467758e-01 0.024 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.467758e-01 0.024 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.467758e-01 0.024 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.467758e-01 0.024 0 0
Complex III assembly R-HSA-9865881 9.467758e-01 0.024 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.472066e-01 0.024 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.486843e-01 0.023 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.486843e-01 0.023 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.491587e-01 0.023 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.491587e-01 0.023 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.498510e-01 0.022 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.499809e-01 0.022 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.517381e-01 0.021 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.517381e-01 0.021 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.517381e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.517381e-01 0.021 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.517381e-01 0.021 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.517381e-01 0.021 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.517381e-01 0.021 0 0
Fertilization R-HSA-1187000 9.517381e-01 0.021 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.517381e-01 0.021 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.519613e-01 0.021 0 0
HIV Transcription Initiation R-HSA-167161 9.519613e-01 0.021 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.519613e-01 0.021 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.519613e-01 0.021 0 0
Translation of Structural Proteins R-HSA-9683701 9.519613e-01 0.021 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.523814e-01 0.021 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.541358e-01 0.020 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.541358e-01 0.020 0 0
Signaling by FGFR R-HSA-190236 9.542943e-01 0.020 0 0
Cellular response to chemical stress R-HSA-9711123 9.559023e-01 0.020 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.559618e-01 0.020 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.562379e-01 0.019 0 0
Urea cycle R-HSA-70635 9.562379e-01 0.019 0 0
Sphingolipid catabolism R-HSA-9845614 9.562379e-01 0.019 0 0
FOXO-mediated transcription R-HSA-9614085 9.568603e-01 0.019 0 0
Interferon gamma signaling R-HSA-877300 9.579760e-01 0.019 0 0
G alpha (s) signalling events R-HSA-418555 9.583040e-01 0.018 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.591724e-01 0.018 0 0
Signaling by FGFR4 R-HSA-5654743 9.591724e-01 0.018 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.591724e-01 0.018 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.591724e-01 0.018 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.598183e-01 0.018 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.603184e-01 0.018 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.603184e-01 0.018 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.603184e-01 0.018 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.603184e-01 0.018 0 0
Triglyceride biosynthesis R-HSA-75109 9.603184e-01 0.018 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.603184e-01 0.018 0 0
Insulin processing R-HSA-264876 9.603184e-01 0.018 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.618029e-01 0.017 0 0
DAP12 interactions R-HSA-2172127 9.623768e-01 0.017 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.623768e-01 0.017 0 0
Amine ligand-binding receptors R-HSA-375280 9.623768e-01 0.017 0 0
Telomere Extension By Telomerase R-HSA-171319 9.640187e-01 0.016 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.640187e-01 0.016 0 0
Insulin receptor recycling R-HSA-77387 9.640187e-01 0.016 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.640187e-01 0.016 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.640187e-01 0.016 0 0
Pyrimidine salvage R-HSA-73614 9.640187e-01 0.016 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.653389e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.653389e-01 0.015 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.653389e-01 0.015 0 0
Signaling by FGFR3 R-HSA-5654741 9.653389e-01 0.015 0 0
Developmental Cell Lineages R-HSA-9734767 9.665822e-01 0.015 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.667874e-01 0.015 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.673741e-01 0.014 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.673741e-01 0.014 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.673741e-01 0.014 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.673741e-01 0.014 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.678733e-01 0.014 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.680760e-01 0.014 0 0
Integrin cell surface interactions R-HSA-216083 9.680772e-01 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.704168e-01 0.013 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.704168e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.704168e-01 0.013 0 0
Activation of BH3-only proteins R-HSA-114452 9.704168e-01 0.013 0 0
Signaling by Insulin receptor R-HSA-74752 9.704184e-01 0.013 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.706042e-01 0.013 0 0
Signaling by FGFR2 R-HSA-5654738 9.721312e-01 0.012 0 0
Intraflagellar transport R-HSA-5620924 9.729388e-01 0.012 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.731759e-01 0.012 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.731759e-01 0.012 0 0
Cellular response to hypoxia R-HSA-1234174 9.733919e-01 0.012 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.742796e-01 0.011 0 0
HS-GAG degradation R-HSA-2024096 9.756778e-01 0.011 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.759513e-01 0.011 0 0
Metabolism of steroid hormones R-HSA-196071 9.770805e-01 0.010 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.772237e-01 0.010 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.779465e-01 0.010 0 0
Potassium Channels R-HSA-1296071 9.785365e-01 0.009 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.789167e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.800037e-01 0.009 0 0
Heme degradation R-HSA-189483 9.800037e-01 0.009 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.806085e-01 0.009 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.806085e-01 0.009 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.817140e-01 0.008 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.817140e-01 0.008 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.818691e-01 0.008 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.818691e-01 0.008 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.818691e-01 0.008 0 0
Hyaluronan metabolism R-HSA-2142845 9.818691e-01 0.008 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.818691e-01 0.008 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.818691e-01 0.008 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.821682e-01 0.008 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.829292e-01 0.007 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.830488e-01 0.007 0 0
ECM proteoglycans R-HSA-3000178 9.830488e-01 0.007 0 0
Regulation of Apoptosis R-HSA-169911 9.835606e-01 0.007 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.835606e-01 0.007 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.835606e-01 0.007 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.835606e-01 0.007 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.836059e-01 0.007 0 0
Infectious disease R-HSA-5663205 9.840220e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.846691e-01 0.007 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.849306e-01 0.007 0 0
HS-GAG biosynthesis R-HSA-2022928 9.850944e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.850944e-01 0.007 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.861509e-01 0.006 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.864851e-01 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.865163e-01 0.006 0 0
Synthesis of PA R-HSA-1483166 9.872748e-01 0.006 0 0
Post-translational protein modification R-HSA-597592 9.874511e-01 0.005 0 0
Purine salvage R-HSA-74217 9.877462e-01 0.005 0 0
Stabilization of p53 R-HSA-69541 9.888897e-01 0.005 0 0
RAS processing R-HSA-9648002 9.888897e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.888897e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.888897e-01 0.005 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.888897e-01 0.005 0 0
G alpha (q) signalling events R-HSA-416476 9.891115e-01 0.005 0 0
Extension of Telomeres R-HSA-180786 9.892622e-01 0.005 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.892622e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9694635 9.892969e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.895566e-01 0.005 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.899265e-01 0.004 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.899265e-01 0.004 0 0
Interleukin-2 family signaling R-HSA-451927 9.899265e-01 0.004 0 0
PCP/CE pathway R-HSA-4086400 9.900944e-01 0.004 0 0
Cholesterol biosynthesis R-HSA-191273 9.900944e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.901388e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.901388e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.901705e-01 0.004 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.901705e-01 0.004 0 0
Signaling by Interleukins R-HSA-449147 9.907587e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.908666e-01 0.004 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.908666e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.908666e-01 0.004 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.909455e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.909589e-01 0.004 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.917190e-01 0.004 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.917190e-01 0.004 0 0
Intra-Golgi traffic R-HSA-6811438 9.917190e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.917190e-01 0.004 0 0
Heme biosynthesis R-HSA-189451 9.917190e-01 0.004 0 0
Toll-like Receptor Cascades R-HSA-168898 9.921248e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.923589e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.923699e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.924920e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.924920e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.924920e-01 0.003 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.931928e-01 0.003 0 0
Defensins R-HSA-1461973 9.931928e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.934652e-01 0.003 0 0
Protein localization R-HSA-9609507 9.936821e-01 0.003 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.938282e-01 0.003 0 0
Proteasome assembly R-HSA-9907900 9.938282e-01 0.003 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.944044e-01 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.944044e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.945919e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.949268e-01 0.002 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.951857e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.958299e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.961757e-01 0.002 0 0
Metabolism of porphyrins R-HSA-189445 9.961757e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.962193e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.964942e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.968924e-01 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.968924e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.968924e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.972057e-01 0.001 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.972452e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.973013e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.974458e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.979249e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.979249e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.979561e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.980993e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.982746e-01 0.001 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.983778e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.984060e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.984156e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.985819e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.985819e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.986064e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.986545e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.987144e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.987144e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.988346e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.989752e-01 0.000 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.992872e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.993427e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.993427e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.993507e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993531e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.994136e-01 0.000 0 0
Disease R-HSA-1643685 9.994421e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.994917e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.995632e-01 0.000 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.995794e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996040e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.996411e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.996411e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.996428e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.996514e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996786e-01 0.000 0 0
Gastrulation R-HSA-9758941 9.997006e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997051e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997277e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997448e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998505e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.998656e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.999005e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999077e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999135e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999177e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999254e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.999324e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999607e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999746e-01 0.000 0 0
Immune System R-HSA-168256 9.999764e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999773e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999821e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999822e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999860e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999869e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999885e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999894e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999915e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999916e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999916e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999942e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999962e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999966e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999968e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999968e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999971e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999985e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999991e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999992e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999994e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways