SIK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A6NMY6 S26 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
A6NMY6 T163 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
A8MPP1 S279 Sugiyama DDX11L8 LVSLGSRQNLCVNEDVRSLGsVQLINDRCVDMQRSRHEKKK
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O00165 S162 Sugiyama HAX1 HS1BP1 GGVLESDARSEsPQPAPDWGsQRPFHRFDDVWPMDPHPRtR
O00231 S298 Sugiyama PSMD11 RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI
O00267 Y802 Sugiyama SUPT5H SPT5 SPT5H sRtPMYGsQtPLQDGsRtPHyGsQtPLHDGsRtPAQsGAWD
O00571 S74 Sugiyama DDX3X DBX DDX3 DKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGsGsRG
O00571 S82 Sugiyama DDX3X DBX DDX3 ssKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRs
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15085 T1292 Sugiyama ARHGEF11 KIAA0380 GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O15226 S618 Sugiyama NKRF ITBA4 NRF VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15523 S74 Sugiyama DDX3Y DBY DKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSGSRGR
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60291 S515 Sugiyama MGRN1 KIAA0544 RNF156 sFItEEVDESssPQQGTRAAsIENVLQDssPEHCGRGPPAD
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75122 S327 Sugiyama CLASP2 KIAA0627 YLKssGsVAsLPQsDRsssssQEsLNRPFSSKWSTANPSTV
O75179 S1457 Sugiyama ANKRD17 GTAR KIAA0697 CMESIVQAKDRQAAEANKNAsILLEELDLEKLREESRRLAL
O75390 S453 Sugiyama CS LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O75643 S17 Sugiyama SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 ____MADVTARsLQYEYKANsNLVLQADRsLIDRTRRDEPT
O75822 S127 Sugiyama EIF3J EIF3S1 PRO0391 VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O76003 S117 Sugiyama GLRX3 PICOT TXNL2 HUSSY-22 IDRLDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRL
O94826 S91 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O94979 S799 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95218 S75 Sugiyama ZRANB2 ZIS ZNF265 tLAEKSRGLFsANDWQCKTCsNVNWARRsECNMCNtPKYAK
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04040 S515 Sugiyama CAT ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040 S517 Sugiyama CAT LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S187 Sugiyama HSPB1 HSP27 HSP28 APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 S219 Sugiyama EIF2S1 EIF2A CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 S26 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07355 T163 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
P07384 S474 Sugiyama CAPN1 CANPL1 PIG30 GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 S40 Sugiyama TUBB TUBB5 OK/SW-cl.56 FWEVISDEHGIDPTGtyHGDsDLQLDRIsVyyNEAtGGKyV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P08195 S252 Sugiyama SLC3A2 MDU1 AFQGHGAGNLAGLKGRLDyLssLKVKGLVLGPIHKNQKDDV
P08195 S286 Sugiyama SLC3A2 MDU1 KNQKDDVAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVIL
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651 S368 Sugiyama HNRNPA1 HNRPA1 FAKPRNQGGyGGssssssyGsGRRF________________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09884 S1447 Sugiyama POLA1 POLA LQDYRKLKNTAEQFLSRSGYsEVNLSKLFAGCAVKS_____
P09923 S189 Sugiyama ALPI RVQHAsPAGtyAHtVNRNWysDADMPASARQEGCQDIATQL
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10768 S189 Sugiyama ESD VSAFAPICNPVLCPWGKKAFsGyLGTDQsKWKAyDAtHLVK
P11142 S329 Sugiyama HSPA8 HSC70 HSP73 HSPA10 LFRGtLDPVEKALRDAKLDKsQIHDIVLVGGstRIPKIQKL
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 S85 Sugiyama HSPA8 HSC70 HSP73 HSPA10 NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11279 S141 Sugiyama LAMP1 NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11388 S390 Sugiyama TOP2A TOP2 NPTFDSQTKENMTLQPKSFGsTCQLSEKFIKAAIGCGIVES
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11532 S3624 Sugiyama DMD AKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEED
P11586 S318 Sugiyama MTHFD1 MTHFC MTHFD FKPGKWMIQYNNLNLKTPVPsDIDIsRSCKPKPIGKLAREI
P11586 S765 Sugiyama MTHFD1 MTHFC MTHFD ARMFGIPVVVAVNAFKTDTEsELDLIsRLSREHGAFDAVKC
P11717 S1952 Sugiyama IGF2R MPRI DYDRDHEWGFCRHSNSYRTssIIFKCDEDEDIGRPQVFSEV
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P13010 Y316 Sugiyama XRCC5 G22P2 CLNDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSE
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667 S124 Sugiyama PDIA4 ERP70 ERP72 IANILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILK
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13797 S540 Sugiyama PLS3 NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798 S187 Sugiyama APEH D3F15S2 D3S48E DNF15S2 EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18031 S15 Sugiyama PTPN1 PTP1B ______MEMEKEFEQIDKsGsWAAIyQDIRHEASDFPCRVA
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19174 S672 Sugiyama PLCG1 PLC1 RLSEPVPQTNAHESKEWYHAsLTRAQAEHMLMRVPRDGAFL
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P20020 S52 Sugiyama ATP2B1 PMCA1 AELRALMELRSTDALRKIQEsyGDVyGICTKLKTSPNEGLS
P21108 S10 Sugiyama PRPS1L1 PRPS3 PRPSL ___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P21108 S11 Sugiyama PRPS1L1 PRPS3 PRPSL __________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333 S2152 Sugiyama FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333 S2158 Sugiyama FLNA FLN FLN1 GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22059 S240 Sugiyama OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22059 S386 Sugiyama OSBP OSBP1 ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22087 S124 Sugiyama FBL FIB1 FLRN DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626 S324 Sugiyama HNRNPA2B1 HNRPA2B1 GNYNQQPSNYGPMKsGNFGGsRNMGGPyGGGNyGPGGsGGs
P23284 S150 Sugiyama PPIB CYPB LKHyGPGWVsMANAGKDTNGsQFFITTVKTAWLDGKHVVFG
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 S406 Sugiyama EIF4B KLQRQLDEPKLERRPRERHPsWRsEEtQERERsRtGsEssQ
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P26038 S144 Sugiyama MSN LLASyAVQSKYGDFNKEVHKsGYLAGDKLLPQRVLEQHKLN
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28066 S180 Sugiyama PSMA5 GtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSLI
P28838 S180 Sugiyama LAP3 LAPEP PEPS YEYDDLKQKKKMAVSAKLyGsGDQEAWQKGVLFAsGQNLAR
P28838 S194 Sugiyama LAP3 LAPEP PEPS SAKLyGsGDQEAWQKGVLFAsGQNLARQLMETPANEMTPtR
P29401 S105 Sugiyama TKT VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30622 S195 Sugiyama CLIP1 CYLN1 RSN AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31327 S835 Sugiyama CPS1 MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31948 S16 Sugiyama STIP1 _____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34897 S90 Sugiyama SHMT2 GLELIAsENFCsRAALEALGsCLNNKYSEGYPGKRyyGGAE
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35568 S794 GPS6|ELM IRS1 tQRPGEPEEGARHQHLRLSTsSGRLLYAATADDSSSStSSD
P35606 S350 Sugiyama COPB2 MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39748 S255 Sugiyama FEN1 RAD2 CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P40818 S718 Sugiyama USP8 KIAA0055 UBPY AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46459 S298 Sugiyama NSF NAREPKVVNGPEILNKyVGEsEANIRKLFADAEEEQRRLGA
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46782 S75 Sugiyama RPS5 RYAAKRFRKAQCPIVERLtNsMMMHGRNNGKKLMTVRIVKH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48637 S276 Sugiyama GSS VDGQEIAVVYFRDGYMPRQYsLQNWEARLLLERSHAAKCPD
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327 S265 Sugiyama FASN FAS TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49368 T254 Sugiyama CCT3 CCTG TRIC5 KNPRIVLLDssLEyKKGEsQtDIEITREEDFTRILQMEEEY
P49588 S627 Sugiyama AARS1 AARS ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P51116 S504 Sugiyama FXR2 FMR1L2 PTGGRGRGPPPAPRPTSRYNsSsISSVLKDPDsNPYSLLDt
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P51991 Y364 Sugiyama HNRNPA3 HNRPA3 GPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF______
P52272 S365 Sugiyama HNRNPM HNRPM NAGR1 KMGGMEGPFGGGMENMGRFGsGMNMGRINEILsNALKRGEI
P52272 S432 Sugiyama HNRNPM HNRPM NAGR1 GGAGMERMGAGLGHGMDRVGsEIERMGLVMDRMGsVERMGs
P52272 S528 Sugiyama HNRNPM HNRPM NAGR1 IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597 S63 Sugiyama HNRNPF HNRPF VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P52788 S57 Sugiyama SMS ESVHTWQDHGYLATYTNKNGsFANLRIYPHGLVLLDLQSYD
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53621 S389 Sugiyama COPA SYNPAENAVLLCTRAsNLENstyDLytIPKDADsQNPDAPE
P54252 S260 Sugiyama ATXN3 ATX3 MJD MJD1 SCA3 IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010 S10 Sugiyama EIF5 ___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55036 S358 Sugiyama PSMD4 MCB1 VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55060 S931 Sugiyama CSE1L CAS XPO2 KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55196 S216 Sugiyama AFDN AF6 MLLT4 SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55769 S122 Sugiyama SNU13 NHP2L1 CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P56524 S246 GPS6 HDAC4 KIAA0288 NHPVLGMYDAKDDFPLRKTAsEPNLKLRSRLKQKVAERRss
P56524 S467 GPS6 HDAC4 KIAA0288 DRVSPSIHKLRQHRPLGRtQsAPLPQNAQALQHLVIQQQHQ
P57059 S117 Sugiyama SIK1 SIK SNF1LK DMLYIVTEFAKNGEMFDYLTsNGHLSENEARKKFWQILSAV
P57059 S186 GPS6|EPSD SIK1 SIK SNF1LK ADFGFGNFYKSGEPLStWCGsPPYAAPEVFEGKEYEGPQLD
P57059 S463 Sugiyama SIK1 SIK SNF1LK AISEEARQGPGLEEEQDtQEsLPSSTGRRHtLAEVSTRLSP
P57059 S534 Sugiyama SIK1 SIK SNF1LK SKsPAGLSGTPATQGLLGACsPVRLASPFLGSQSATPVLQA
P57059 S575 Sugiyama SIK1 SIK SNF1LK QGGLGGAVLLPVSFQEGRRAsDtSLtQGLKAFRQQLRKTTR
P57059 S626 Sugiyama SIK1 SIK SNF1LK KGLARQVCQAPASRASRGGLsPFHAPAQsPGLHGGAAGsRE
P57059 S634 Sugiyama SIK1 SIK SNF1LK QAPASRASRGGLsPFHAPAQsPGLHGGAAGsREGWSLLEEV
P57059 S644 Sugiyama SIK1 SIK SNF1LK GLsPFHAPAQsPGLHGGAAGsREGWSLLEEVLEQQRLLQLQ
P57059 T460 Sugiyama SIK1 SIK SNF1LK LDTAISEEARQGPGLEEEQDtQEsLPSSTGRRHtLAEVSTR
P57059 T580 Sugiyama SIK1 SIK SNF1LK GAVLLPVSFQEGRRAsDtSLtQGLKAFRQQLRKTTRTKGFL
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60891 S10 Sugiyama PRPS1 ___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P60891 S11 Sugiyama PRPS1 __________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61163 T248 Sugiyama ACTR1A CTRN1 PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61247 S203 Sugiyama RPS3A FTE1 MFTL EVVNKLIPDsIGKDIEKACQsIyPLHDVFVRKVKMLKKPKF
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61326 S106 Sugiyama MAGOH MAGOHA QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62081 T121 Sugiyama RPS7 LPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVG
P62081 T123 Sugiyama RPS7 KPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVGKR
P62241 S115 Sugiyama RPS8 OK/SW-cl.83 TLVKNCIVLIDStPYRQWyEsHyALPLGRKKGAKLtPEEEE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750 S43 Sugiyama RPL23A KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62750 T126 Sugiyama RPL23A KHQIKQAVKKLyDIDVAKVNtLIRPDGEKKAYVRLAPDyDA
P62826 S135 Sugiyama RAN ARA24 OK/SW-cl.81 IPIVLCGNKVDIKDRKVKAKsIVFHRKKNLQyyDIsAKSNy
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P78371 S150 Sugiyama CCT2 99D8.1 CCTB WREATKAAREALLssAVDHGsDEVKFRQDLMNIAGTTLssK
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09666 S220 Sugiyama AHNAK PM227 QsGKtVIRLPsGsGAAsPtGsAVDIRAGAIsAsGPELQGAG
Q10471 S536 Sugiyama GALNT2 NDSRQKWEQIEGNSKLRHVGsNLCLDSRTAKSGGLSVEVCG
Q12849 S202 Sugiyama GRSF1 IHFLLNRDGKRRGDALIEMEsEQDVQKALEKHRMYMGQRYV
Q13098 S483 Sugiyama GPS1 COPS1 CSN1 QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13136 S668 Sugiyama PPFIA1 LIP1 EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13136 S763 Sugiyama PPFIA1 LIP1 PssPRALRLDRLHKGALHtVsHEDIRDIRNstGsQDGPVSN
Q13243 S153 Sugiyama SRSF5 HRS SFRS5 SRP40 EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283 S362 Sugiyama G3BP1 G3BP LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13501 S266 Sugiyama SQSTM1 ORCA OSIL AALsPLGIEVDIDVEHGGKRsRLtPVsPEssstEEKsssQP
Q13501 T269 Sugiyama SQSTM1 ORCA OSIL sPLGIEVDIDVEHGGKRsRLtPVsPEssstEEKsssQPssC
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14151 S827 Sugiyama SAFB2 KIAA0138 HGGPPERHGRDsRDGWGGyGsDKRLsEGRGLPPPPRGGRDW
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14204 S3257 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 NDKLKKMVKDQQEAEKKKVMsQEIQEQLHKQQEVIADKQMS
Q14204 S4162 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL
Q14258 S340 Sugiyama TRIM25 EFP RNF147 ZNF147 KPVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTP
Q14258 T341 Sugiyama TRIM25 EFP RNF147 ZNF147 PVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTPS
Q14432 S273 Sugiyama PDE3A RYVEQILPQSAEAAPREHLGsQLIAGTKEDIPVFKRRRRss
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14498 S334 Sugiyama RBM39 HCC1 RNPC2 FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14498 S97 Sugiyama RBM39 HCC1 RNPC2 KERRRSRSRSRDRRFRGRyRsPysGPKFNSAIRGKIGLPHs
Q14566 S568 Sugiyama MCM6 IARRIVDLHSRIEESIDRVYsLDDIRRyLLFARQFKPKISK
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14980 S1181 Sugiyama NUMA1 NMP22 NUMA DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q14C86 S900 Sugiyama GAPVD1 GAPEX5 KIAA1521 RAP6 TPAEMEAFKQRHSYPERLVRsRssDIVSSVRRPMSDPSWNR
Q14C86 S902 Sugiyama GAPVD1 GAPEX5 KIAA1521 RAP6 AEMEAFKQRHSYPERLVRsRssDIVSSVRRPMSDPSWNRRP
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15021 S1310 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 RACHTRGLDGIKELEIGQAGsQRAPsAKKPSTGSRyQPLAs
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15424 S803 Sugiyama SAFB HAP HET SAFB1 RHGGPERHGRDsRDGWGGyGsDKRMsEGRGLPPPPRRDWGD
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15751 S1514 Sugiyama HERC1 AESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRRNV
Q15751 S3238 Sugiyama HERC1 IRTLVRLMCLAAAGRAGLSTsPsAMAsTSERSRGGHSKANK
Q15751 S3240 Sugiyama HERC1 TLVRLMCLAAAGRAGLSTsPsAMAsTSERSRGGHSKANKPI
Q15751 S3244 Sugiyama HERC1 LMCLAAAGRAGLSTsPsAMAsTSERSRGGHSKANKPISCLA
Q15785 S160 Sugiyama TOMM34 URCC3 WRLKLPSIPLVPVsAQKRWNsLPSENHKEMAKSKSKETTAT
Q15818 S91 Sugiyama NPTX1 TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16658 S234 Sugiyama FSCN1 FAN1 HSN SNL LEFRsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELF
Q16719 S443 Sugiyama KYNU VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q27J81 T1206 Sugiyama INF2 C14orf151 C14orf173 DtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKKRP
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3KQU3 S366 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 GPQPDRTHPSAAVPVCPRsAsAsPLtPCSVTRSVHRCAPAG
Q3MII6 S506 Sugiyama TBC1D25 OATL1 DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q53EL6 S46 Sugiyama PDCD4 H731 GDEENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKN
Q53ET0 S171 GPS6|SIGNOR|iPTMNet CRTC2 TORC2 NFPAEKGQLFRLPSALNRtssDsALHtsVMNPsPQDtYPGP
Q53ET0 S348 SIGNOR|iPTMNet CRTC2 TORC2 GYDAPGLHSPLSHPSLQSSLsNPNLQASLSSPQPQLQGSHS
Q53ET0 S70 SIGNOR|iPTMNet CRTC2 TORC2 TRLQAQKLRLAYTRssHyGGsLPNVNQIGsGLAEFQsPLHs
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5HYK3 S165 Sugiyama COQ5 NLSWEEIAKEYQNEEDSLGGsRVVVCDINKEMLKVGKQKAL
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5VWQ8 S747 Sugiyama DAB2IP AF9Q34 AIP1 KIAA1743 ssysEANEPDLQMANGGKsLsMVDLQDARTLDGEAGsPAGP
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6FI81 S305 Sugiyama CIAPIN1 CUA001 PRO0915 CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6GYQ0 T798 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q6UUV7 S162 SIGNOR CRTC3 TORC3 PWKDEKHPGFRLTSALNRtNsDSALHtsALsTKPQDPYGGG
Q6UUV9 S151 GPS6 CRTC1 KIAA0616 MECT1 TORC1 WAMTP1 CPYGTMYLsPPADTSWRRtNsDsALHQstMtPtQPEsFssG
Q6UUV9 S167 SIGNOR CRTC1 KIAA0616 MECT1 TORC1 WAMTP1 RRtNsDsALHQstMtPtQPEsFssGsQDVHQKRVLLLTVPG
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z2W4 S492 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 VQATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEI
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5L9 S360 Sugiyama IRF2BP2 EANGANGSKAVARTARKRKPsPEPEGEVGPPKINGEAQPWL
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86VQ1 S226 Sugiyama GLCCI1 sCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQRSKQ
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NEY1 S312 Sugiyama NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 TCYDsDDANPRsVssLsNRssPLSWRYGQSSPRLQAGDAPS
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TB72 S943 Sugiyama PUM2 KIAA0235 PUMH2 NYVIQHVLEHGRPEDKSKIVsEIRGKVLALSQHKFASNVVE
Q8WUF5 S102 Sugiyama PPP1R13L IASPP NKIP1 PPP1R13BL RAI RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q8WWH5 S268 Sugiyama TRUB1 PUS4 ECGGGFYIRSLVSDIGKELSsCANVLELTRTKQGPFTLEEH
Q8WXH0 S2781 Sugiyama SYNE2 KIAA1011 NUA ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q96A72 S108 Sugiyama MAGOHB MAGOH2 QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
Q96EP5 S208 Sugiyama DAZAP1 AEPRDsKsQAPGQPGAsQWGsRVVPNAANGWAGQPPPTWQQ
Q96ES7 S29 Sugiyama SGF29 CCDC101 RIAELLTELHQLIKQTQEERsRsEHNLVNIQKTHERMQTEN
Q96ES7 S31 Sugiyama SGF29 CCDC101 AELLTELHQLIKQTQEERsRsEHNLVNIQKTHERMQTENKI
Q96EY7 S651 Sugiyama PTCD3 MRPS39 TRG15 VELASAFSLPICEGLTQRVMsDFAINQEQKEALsNLtALts
Q96FC9 S277 Sugiyama DDX11 CHL1 CHLR1 KRG2 LVSLGSRQNLCVNEDVKSLGsVQLINDRCVDMQRSRHEKKK
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96PK6 S523 Sugiyama RBM14 SIP AYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASYRGQ
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BS40 S41 Sugiyama LXN INyQQGTPHRVFEVQKVKQAsMEDIPGRGHKYHLKFAVEEI
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BZ72 S644 Sugiyama PITPNM2 KIAA1457 NIR3 SGGGGSSGGSSLESSRHLsRsNVDIPRSNGTEDPKRQLPRK
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H0H5 S257 Sugiyama RACGAP1 KIAA1478 MGCRACGAP ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H1K0 S548 Sugiyama RBSN ZFYVE20 RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH
Q9H694 S803 Sugiyama BICC1 YKPTMTTTYEGSsMsLsRsNsREHLGGGSESDNWRDRNGIG
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9HAU0 S410 Sugiyama PLEKHA5 KIAA1686 PEPP2 NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN4 S301 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NQP4 S125 Sugiyama PFDN4 PFD4 VEsIQRVLADLKVQLYAKFGsNINLEADEs___________
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9NVX2 S331 Sugiyama NLE1 HUSSY-07 ASVNPQDLQGSLQELKERALsRYNLVRGQGPERLVSGSDDF
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NWS0 S173 Sugiyama PIH1D1 NOP17 KYNLQLNPEWRMMKNRPFMGsIsQQNIRSEQRPRIQELGDL
Q9NYB9 S22 Sugiyama ABI2 ARGBPIA AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9NZM1 S727 Sugiyama MYOF FER1L3 KIAA1207 PLTEGKANVTVLDTQIRKLRsRsLsQIHEAAVRMRSEATDV
Q9P1Y5 S431 Sugiyama CAMSAP3 KIAA1543 FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9P265 S203 Sugiyama DIP2B KIAA1463 stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBC2 S672 Sugiyama EPS15L1 EPS15R ttstDPFGGDPFKESDPFRGsAtDDFFKKQTKNDPFTSDPF
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UIQ6 S51 Sugiyama LNPEP OTASE AKEPCLHPLEPDEVEyEPRGsRLLVRGLGEHEMEEDEEDyE
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UNZ2 S74 Sugiyama NSFL1C UBXN2C SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9UPQ0 S207 Sugiyama LIMCH1 KIAA1102 RsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssD
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S2398 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ANLtsPRVPLsAyERVsGRtsPPLLDRARsRtPPsAPsQsR
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 S335 Sugiyama PA2G4 EBP1 FVAQFKFTVLLMPNGPMRITsGPFEPDLyKsEMEVQDAELK
Q9UQL6 S259 GPS6 HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 GPS6 HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y2B0 S178 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NVKDKLCSKRtDLCDHALHIsHDEL________________
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2B0 T79 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2U5 S239 Sugiyama MAP3K2 MAPKKK2 MEKK2 SLDSPLDGESYPKSRMPRAQsyPDNHQEFSDyDNPIFEKFG
Q9Y2V2 S52 Sugiyama CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y490 S1535 Sugiyama TLN1 KIAA1027 TLN RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6 S1537 Sugiyama TLN2 KIAA0320 KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR
Q9Y4W2 S636 Sugiyama LAS1L MSTP060 EsPtAENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMP
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5S2 S470 Sugiyama CDC42BPB KIAA1124 LEQEKLELSRKLQESTQTVQsLHGsSRALSNsNRDKEIKKL
Q9Y5S2 S474 Sugiyama CDC42BPB KIAA1124 KLELSRKLQESTQTVQsLHGsSRALSNsNRDKEIKKLNEEI
Q9Y618 T1383 PSP NCOR2 CTG26 YVEAQEDYLRREAKLLKREGtPPPPPPSRDLTEAYKTQALG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 1.455246e-08 7.837 0 0
Cell Cycle R-HSA-1640170 1.582664e-06 5.801 0 0
G alpha (12/13) signalling events R-HSA-416482 1.433335e-05 4.844 0 0
Cell Cycle, Mitotic R-HSA-69278 1.912853e-05 4.718 0 0
NRAGE signals death through JNK R-HSA-193648 1.831008e-05 4.737 0 0
Mitotic Prometaphase R-HSA-68877 3.170919e-05 4.499 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.810238e-05 4.419 0 0
Axon guidance R-HSA-422475 4.028285e-05 4.395 0 0
Post NMDA receptor activation events R-HSA-438064 9.266227e-05 4.033 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.082411e-04 3.966 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.253888e-04 3.647 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.528032e-04 3.597 0 0
Interleukin-37 signaling R-HSA-9008059 3.454604e-04 3.462 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.765696e-04 3.424 0 0
Nervous system development R-HSA-9675108 4.098170e-04 3.387 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.174089e-04 3.379 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.202408e-04 3.284 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.547779e-04 3.256 0 0
M Phase R-HSA-68886 6.404816e-04 3.193 0 0
Cell Cycle Checkpoints R-HSA-69620 6.497924e-04 3.187 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.114763e-04 3.148 0 0
Death Receptor Signaling R-HSA-73887 7.621181e-04 3.118 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.083866e-03 2.965 0 0
G2/M Transition R-HSA-69275 1.076684e-03 2.968 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.232647e-03 2.909 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.283001e-03 2.892 0 0
Semaphorin interactions R-HSA-373755 1.299706e-03 2.886 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.257589e-03 2.900 0 0
Regulation of TP53 Activity R-HSA-5633007 1.398253e-03 2.854 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.599831e-03 2.796 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.574310e-03 2.803 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.754882e-03 2.756 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.719901e-03 2.764 0 0
Kinesins R-HSA-983189 1.848243e-03 2.733 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.367146e-03 2.626 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.785488e-03 2.555 0 0
HDMs demethylate histones R-HSA-3214842 2.862181e-03 2.543 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.236685e-03 2.490 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.236685e-03 2.490 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.263896e-03 2.486 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.236685e-03 2.490 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.463165e-03 2.461 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.463165e-03 2.461 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.487829e-03 2.457 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.817696e-03 2.418 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.921589e-03 2.407 0 0
Membrane Trafficking R-HSA-199991 4.096160e-03 2.388 0 0
L1CAM interactions R-HSA-373760 4.164069e-03 2.380 0 0
PI Metabolism R-HSA-1483255 4.367918e-03 2.360 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.535502e-03 2.343 0 0
Rab regulation of trafficking R-HSA-9007101 4.611874e-03 2.336 0 0
DAG and IP3 signaling R-HSA-1489509 4.693738e-03 2.328 0 0
Chromatin modifying enzymes R-HSA-3247509 4.705399e-03 2.327 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.783121e-03 2.238 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.530724e-03 2.257 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.544843e-03 2.256 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.693346e-03 2.245 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.530724e-03 2.257 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.530724e-03 2.257 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.402833e-03 2.267 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.544843e-03 2.256 0 0
Signaling by RAS mutants R-HSA-6802949 5.530724e-03 2.257 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.150982e-03 2.288 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.219502e-03 2.282 0 0
Apoptotic execution phase R-HSA-75153 5.530724e-03 2.257 0 0
Muscle contraction R-HSA-397014 5.957608e-03 2.225 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.057095e-03 2.218 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.359539e-03 2.197 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.359539e-03 2.197 0 0
Recycling pathway of L1 R-HSA-437239 6.484257e-03 2.188 0 0
Centrosome maturation R-HSA-380287 7.132821e-03 2.147 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.841147e-03 2.165 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.813698e-03 2.167 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.565451e-03 2.121 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.179501e-03 2.087 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.201088e-03 2.086 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.189203e-03 2.087 0 0
Long-term potentiation R-HSA-9620244 8.201088e-03 2.086 0 0
Chromatin organization R-HSA-4839726 8.409697e-03 2.075 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.686027e-03 2.014 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.686027e-03 2.014 0 0
Separation of Sister Chromatids R-HSA-2467813 9.717262e-03 2.012 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.012731e-02 1.995 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.019081e-02 1.992 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.042829e-02 1.982 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.223974e-02 1.912 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.212666e-02 1.916 0 0
Calmodulin induced events R-HSA-111933 1.179410e-02 1.928 0 0
CaM pathway R-HSA-111997 1.179410e-02 1.928 0 0
Neuronal System R-HSA-112316 1.217043e-02 1.915 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.572821e-02 1.803 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.572821e-02 1.803 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.572821e-02 1.803 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.572821e-02 1.803 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.445804e-02 1.840 0 0
Activation of RAC1 R-HSA-428540 1.445804e-02 1.840 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.475341e-02 1.831 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.474813e-02 1.831 0 0
Integrin signaling R-HSA-354192 1.441301e-02 1.841 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.441301e-02 1.841 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.475341e-02 1.831 0 0
Neurexins and neuroligins R-HSA-6794361 1.340233e-02 1.873 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.514041e-02 1.820 0 0
NGF-stimulated transcription R-HSA-9031628 1.647573e-02 1.783 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.441301e-02 1.841 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.456958e-02 1.837 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.394524e-02 1.856 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.477899e-02 1.830 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.662099e-02 1.779 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.700996e-02 1.769 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.770559e-02 1.752 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.791696e-02 1.747 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.762094e-02 1.754 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.864949e-02 1.729 0 0
Mitotic Anaphase R-HSA-68882 1.834307e-02 1.737 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.770559e-02 1.752 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.811202e-02 1.742 0 0
Nephrin family interactions R-HSA-373753 1.770559e-02 1.752 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.889251e-02 1.724 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.915344e-02 1.718 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.915344e-02 1.718 0 0
FOXO-mediated transcription R-HSA-9614085 1.931236e-02 1.714 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.949653e-02 1.710 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.140414e-02 1.670 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.141296e-02 1.669 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.143787e-02 1.669 0 0
Aggrephagy R-HSA-9646399 2.177463e-02 1.662 0 0
Ion homeostasis R-HSA-5578775 2.225253e-02 1.653 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.479340e-02 1.606 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.479340e-02 1.606 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.322854e-02 1.634 0 0
Potassium Channels R-HSA-1296071 2.551287e-02 1.593 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.623168e-02 1.581 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.737783e-02 1.563 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.820758e-02 1.550 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.820758e-02 1.550 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.820758e-02 1.550 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.820758e-02 1.550 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.820758e-02 1.550 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.820758e-02 1.550 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.820758e-02 1.550 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.216564e-02 1.493 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.160340e-02 1.500 0 0
Voltage gated Potassium channels R-HSA-1296072 3.096143e-02 1.509 0 0
Ca-dependent events R-HSA-111996 3.260128e-02 1.487 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.216564e-02 1.493 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.318052e-02 1.479 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.330336e-02 1.478 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.330336e-02 1.478 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.330336e-02 1.478 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.341812e-02 1.476 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.369167e-02 1.472 0 0
TBC/RABGAPs R-HSA-8854214 3.694275e-02 1.432 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.713516e-02 1.430 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.713516e-02 1.430 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.893506e-02 1.410 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.136244e-02 1.383 0 0
Rap1 signalling R-HSA-392517 3.893506e-02 1.410 0 0
Cilium Assembly R-HSA-5617833 3.839595e-02 1.416 0 0
PLC beta mediated events R-HSA-112043 3.876485e-02 1.412 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.037165e-02 1.394 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.916155e-02 1.407 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.235261e-02 1.373 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.272828e-02 1.369 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.291026e-02 1.367 0 0
Heme signaling R-HSA-9707616 4.291026e-02 1.367 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.291026e-02 1.367 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.400319e-02 1.357 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.400319e-02 1.357 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.402037e-02 1.356 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.402037e-02 1.356 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.402037e-02 1.356 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.402037e-02 1.356 0 0
Neurodegenerative Diseases R-HSA-8863678 4.418510e-02 1.355 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.418510e-02 1.355 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.734782e-02 1.325 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.657409e-02 1.332 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.657409e-02 1.332 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.657409e-02 1.332 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.657409e-02 1.332 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.777436e-02 1.321 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.681878e-02 1.330 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.014011e-02 1.300 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.623239e-02 1.335 0 0
Cellular response to heat stress R-HSA-3371556 5.141555e-02 1.289 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.155838e-02 1.288 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.253504e-02 1.280 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.411111e-02 1.267 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.510866e-02 1.259 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.627952e-02 1.250 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.627952e-02 1.250 0 0
MAPK family signaling cascades R-HSA-5683057 5.642018e-02 1.249 0 0
RET signaling R-HSA-8853659 5.682281e-02 1.245 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.682281e-02 1.245 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.836559e-02 1.234 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 5.836559e-02 1.234 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.372342e-02 1.196 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.906580e-02 1.229 0 0
Signaling by ERBB2 R-HSA-1227986 6.363513e-02 1.196 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.268704e-02 1.203 0 0
Homology Directed Repair R-HSA-5693538 6.492138e-02 1.188 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.247202e-02 1.204 0 0
Hedgehog 'off' state R-HSA-5610787 5.831563e-02 1.234 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.249025e-02 1.204 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.372342e-02 1.196 0 0
TRP channels R-HSA-3295583 5.968010e-02 1.224 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.968010e-02 1.224 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.406362e-02 1.193 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.356508e-02 1.197 0 0
NrCAM interactions R-HSA-447038 6.372342e-02 1.196 0 0
Sensory processing of sound R-HSA-9659379 6.525379e-02 1.185 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.612606e-02 1.180 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.724990e-02 1.172 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.838007e-02 1.165 0 0
G-protein mediated events R-HSA-112040 6.838007e-02 1.165 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.856331e-02 1.164 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.856331e-02 1.164 0 0
Signaling by NTRKs R-HSA-166520 6.871526e-02 1.163 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.904394e-02 1.161 0 0
Signaling by Hippo R-HSA-2028269 6.904394e-02 1.161 0 0
Specification of primordial germ cells R-HSA-9827857 6.904394e-02 1.161 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.230040e-02 1.141 0 0
ARMS-mediated activation R-HSA-170984 7.230040e-02 1.141 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.230040e-02 1.141 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.129086e-02 1.090 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.129086e-02 1.090 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.129086e-02 1.090 0 0
Ephrin signaling R-HSA-3928664 8.129086e-02 1.090 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.081971e-02 1.150 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.980696e-02 1.098 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.774760e-02 1.109 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.230040e-02 1.141 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.261787e-02 1.139 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.762441e-02 1.110 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.187186e-02 1.143 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.141185e-02 1.146 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.081971e-02 1.150 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.228878e-02 1.141 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.129086e-02 1.090 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.025377e-02 1.096 0 0
Cardiac conduction R-HSA-5576891 7.271052e-02 1.138 0 0
Calcineurin activates NFAT R-HSA-2025928 7.230040e-02 1.141 0 0
Signaling by VEGF R-HSA-194138 7.105433e-02 1.148 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.230040e-02 1.141 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.230040e-02 1.141 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.774760e-02 1.109 0 0
TRAIL signaling R-HSA-75158 8.677422e-02 1.062 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.677422e-02 1.062 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.677422e-02 1.062 0 0
Meiotic recombination R-HSA-912446 8.681609e-02 1.061 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.699224e-02 1.061 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.699224e-02 1.061 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.770017e-02 1.057 0 0
Platelet calcium homeostasis R-HSA-418360 8.863687e-02 1.052 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 9.037972e-02 1.044 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.037972e-02 1.044 0 0
Tandem pore domain potassium channels R-HSA-1296346 9.037972e-02 1.044 0 0
Glycolysis R-HSA-70171 9.135030e-02 1.039 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.466735e-02 1.024 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.466735e-02 1.024 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.483915e-02 1.023 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.506965e-02 1.022 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.551335e-02 1.020 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 9.551335e-02 1.020 0 0
Potassium transport channels R-HSA-1296067 9.551335e-02 1.020 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.213413e-01 0.916 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.213413e-01 0.916 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.279652e-01 0.642 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.279652e-01 0.642 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.279652e-01 0.642 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.279652e-01 0.642 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.127926e-01 0.948 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.826389e-01 0.738 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.826389e-01 0.738 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.216558e-01 0.493 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.216558e-01 0.493 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.216558e-01 0.493 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.216558e-01 0.493 0 0
Mitochondrial transcription initiation R-HSA-163282 3.216558e-01 0.493 0 0
Intestinal infectious diseases R-HSA-8942233 3.216558e-01 0.493 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.216558e-01 0.493 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.216558e-01 0.493 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.216558e-01 0.493 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.216558e-01 0.493 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.216558e-01 0.493 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.216558e-01 0.493 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.216558e-01 0.493 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.216558e-01 0.493 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.216558e-01 0.493 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.216558e-01 0.493 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.216558e-01 0.493 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.216558e-01 0.493 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.216558e-01 0.493 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.413539e-01 0.850 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.413539e-01 0.850 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.413539e-01 0.850 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.295172e-01 0.639 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.295172e-01 0.639 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.295172e-01 0.639 0 0
G2 Phase R-HSA-68911 2.295172e-01 0.639 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.295172e-01 0.639 0 0
Type I hemidesmosome assembly R-HSA-446107 1.720156e-01 0.764 0 0
Regulation by c-FLIP R-HSA-3371378 1.720156e-01 0.764 0 0
Dimerization of procaspase-8 R-HSA-69416 1.720156e-01 0.764 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.720156e-01 0.764 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.321852e-01 0.879 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.031296e-01 0.987 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.206346e-01 0.919 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.555770e-01 0.808 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.043379e-01 0.690 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.043379e-01 0.690 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.043379e-01 0.690 0 0
WNT mediated activation of DVL R-HSA-201688 2.043379e-01 0.690 0 0
CASP8 activity is inhibited R-HSA-5218900 2.043379e-01 0.690 0 0
ALK mutants bind TKIs R-HSA-9700645 2.043379e-01 0.690 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.770580e-01 0.557 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.770580e-01 0.557 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.770580e-01 0.557 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.770580e-01 0.557 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.770580e-01 0.557 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.770580e-01 0.557 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.039814e-01 0.394 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.039814e-01 0.394 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.039814e-01 0.394 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.039814e-01 0.394 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.039814e-01 0.394 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.246868e-01 0.904 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.378970e-01 0.624 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.115175e-01 0.953 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.115175e-01 0.953 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.982380e-02 1.001 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.063716e-01 0.685 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.063716e-01 0.685 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.244108e-01 0.489 0 0
CREB phosphorylation R-HSA-199920 3.244108e-01 0.489 0 0
STAT5 Activation R-HSA-9645135 3.244108e-01 0.489 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.244108e-01 0.489 0 0
PKA activation R-HSA-163615 1.804582e-01 0.744 0 0
PKA activation in glucagon signalling R-HSA-164378 1.804582e-01 0.744 0 0
Notch-HLH transcription pathway R-HSA-350054 1.587475e-01 0.799 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.722954e-01 0.565 0 0
DCC mediated attractive signaling R-HSA-418885 2.333619e-01 0.632 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.333619e-01 0.632 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.333619e-01 0.632 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.024777e-01 0.694 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.519339e-01 0.818 0 0
Striated Muscle Contraction R-HSA-390522 1.519339e-01 0.818 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.722708e-01 0.764 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.722708e-01 0.764 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.963462e-01 0.707 0 0
Deadenylation of mRNA R-HSA-429947 1.963462e-01 0.707 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.253376e-01 0.647 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.253376e-01 0.647 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.611378e-01 0.583 0 0
Phosphorylation of the APC/C R-HSA-176412 2.611378e-01 0.583 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.611378e-01 0.583 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.071677e-01 0.513 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.071677e-01 0.513 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.071677e-01 0.513 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.709216e-01 0.431 0 0
CHL1 interactions R-HSA-447041 3.709216e-01 0.431 0 0
Netrin mediated repulsion signals R-HSA-418886 3.709216e-01 0.431 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.709216e-01 0.431 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.709216e-01 0.431 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.709216e-01 0.431 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.709216e-01 0.431 0 0
Axonal growth stimulation R-HSA-209563 4.763199e-01 0.322 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.763199e-01 0.322 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.763199e-01 0.322 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.763199e-01 0.322 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.763199e-01 0.322 0 0
Invadopodia formation R-HSA-8941237 4.763199e-01 0.322 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 4.763199e-01 0.322 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.763199e-01 0.322 0 0
Defective CYP7B1 causes SPG5A and CBAS3 R-HSA-5579013 4.763199e-01 0.322 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.763199e-01 0.322 0 0
MET activates PTPN11 R-HSA-8865999 4.763199e-01 0.322 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.037832e-01 0.984 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.473775e-01 0.832 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.473775e-01 0.832 0 0
RAF activation R-HSA-5673000 1.666841e-01 0.778 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.893419e-01 0.723 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.893419e-01 0.723 0 0
Activation of the pre-replicative complex R-HSA-68962 1.893419e-01 0.723 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.893419e-01 0.723 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.893419e-01 0.723 0 0
HIV Transcription Elongation R-HSA-167169 1.608002e-01 0.794 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.608002e-01 0.794 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.608002e-01 0.794 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.608002e-01 0.794 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.820600e-01 0.740 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.894969e-01 0.538 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.070647e-01 0.684 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.070647e-01 0.684 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.747852e-01 0.757 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.368729e-01 0.625 1 1
p75NTR recruits signalling complexes R-HSA-209543 3.421848e-01 0.466 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.421848e-01 0.466 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.421848e-01 0.466 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.421848e-01 0.466 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.421848e-01 0.466 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.421848e-01 0.466 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.421848e-01 0.466 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.421848e-01 0.466 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.101736e-01 0.958 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.580252e-01 0.588 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.182452e-01 0.497 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.182452e-01 0.497 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.182452e-01 0.497 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.182452e-01 0.497 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.182452e-01 0.497 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.160975e-01 0.381 0 0
Formation of annular gap junctions R-HSA-196025 4.160975e-01 0.381 0 0
Activation of RAS in B cells R-HSA-1169092 4.160975e-01 0.381 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.442306e-01 0.612 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.976977e-01 0.526 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.770546e-01 0.424 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.770546e-01 0.424 0 0
Late endosomal microautophagy R-HSA-9615710 3.016720e-01 0.520 0 0
Transcription of the HIV genome R-HSA-167172 1.922291e-01 0.716 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.960267e-01 0.708 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.687537e-01 0.571 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.687537e-01 0.571 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.033395e-01 0.518 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.033395e-01 0.518 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.115229e-01 0.386 0 0
Lipophagy R-HSA-9613354 4.595777e-01 0.338 0 0
Gap junction degradation R-HSA-190873 4.595777e-01 0.338 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.595777e-01 0.338 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.398825e-01 0.268 0 0
NADE modulates death signalling R-HSA-205025 5.398825e-01 0.268 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.398825e-01 0.268 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.398825e-01 0.268 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.398825e-01 0.268 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.398825e-01 0.268 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.398825e-01 0.268 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.398825e-01 0.268 0 0
Metabolism of non-coding RNA R-HSA-194441 2.549933e-01 0.593 0 0
snRNP Assembly R-HSA-191859 2.549933e-01 0.593 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 3.731182e-01 0.428 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.224096e-01 0.492 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.691951e-01 0.433 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.453717e-01 0.351 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.772944e-01 0.557 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.336506e-01 0.363 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.336506e-01 0.363 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.336506e-01 0.363 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.011085e-01 0.300 0 0
Dual incision in TC-NER R-HSA-6782135 3.517667e-01 0.454 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.235605e-01 0.373 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.235605e-01 0.373 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.797757e-01 0.420 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.204368e-01 0.657 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.146117e-01 0.382 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.065112e-01 0.391 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.065112e-01 0.391 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.618544e-01 0.335 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.618544e-01 0.335 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.490467e-01 0.457 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.856940e-01 0.414 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.485253e-01 0.348 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.485253e-01 0.348 0 0
HIV elongation arrest and recovery R-HSA-167287 4.485253e-01 0.348 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.485253e-01 0.348 0 0
Dual Incision in GG-NER R-HSA-5696400 4.372106e-01 0.359 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.892228e-01 0.410 0 0
mRNA Splicing R-HSA-72172 3.100354e-01 0.509 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.479639e-01 0.349 0 0
HIV Transcription Initiation R-HSA-167161 4.479639e-01 0.349 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.479639e-01 0.349 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.895501e-01 0.310 0 0
FGFR2 alternative splicing R-HSA-6803529 4.895501e-01 0.310 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.105106e-01 0.292 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.105106e-01 0.292 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.405226e-01 0.267 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.405226e-01 0.267 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.405226e-01 0.267 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.405226e-01 0.267 0 0
Signaling by APC mutants R-HSA-4839744 5.405226e-01 0.267 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.405226e-01 0.267 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.405226e-01 0.267 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.405226e-01 0.267 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.463714e-01 0.350 0 0
G1/S-Specific Transcription R-HSA-69205 4.818487e-01 0.317 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.818487e-01 0.317 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.888546e-01 0.311 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.415290e-01 0.266 0 0
mRNA 3'-end processing R-HSA-72187 5.134555e-01 0.289 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.134555e-01 0.289 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.430360e-01 0.265 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.430360e-01 0.265 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.777222e-01 0.238 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.777222e-01 0.238 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.777222e-01 0.238 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.777222e-01 0.238 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.288041e-01 0.277 0 0
Meiotic synapsis R-HSA-1221632 5.319118e-01 0.274 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 5.713792e-01 0.243 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.686704e-01 0.245 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.674877e-01 0.246 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.686928e-01 0.245 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.767192e-01 0.239 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.138291e-01 0.670 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.345422e-01 0.871 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 1.088560e-01 0.963 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.218876e-01 0.914 0 0
G1/S Transition R-HSA-69206 2.075657e-01 0.683 0 0
Specification of the neural plate border R-HSA-9834899 2.024777e-01 0.694 0 0
HATs acetylate histones R-HSA-3214847 2.636769e-01 0.579 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.982380e-02 1.001 0 0
Protein folding R-HSA-391251 1.781054e-01 0.749 0 0
p75NTR signals via NF-kB R-HSA-193639 2.333619e-01 0.632 0 0
Formation of definitive endoderm R-HSA-9823730 4.050521e-01 0.392 0 0
Nucleotide Excision Repair R-HSA-5696398 2.620515e-01 0.582 0 0
DARPP-32 events R-HSA-180024 1.722708e-01 0.764 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.770546e-01 0.424 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.011085e-01 0.300 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.037658e-01 0.298 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.230074e-01 0.910 0 0
Telomere Extension By Telomerase R-HSA-171319 2.796542e-01 0.553 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.549933e-01 0.593 0 0
Circadian clock R-HSA-9909396 4.526184e-01 0.344 1 0
Prolonged ERK activation events R-HSA-169893 1.206346e-01 0.919 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.867731e-01 0.729 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.075657e-01 0.683 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.075657e-01 0.683 0 0
ESR-mediated signaling R-HSA-8939211 1.777118e-01 0.750 0 0
Chromosome Maintenance R-HSA-73886 5.767192e-01 0.239 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.378443e-01 0.861 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.105106e-01 0.292 0 0
Telomere Maintenance R-HSA-157579 5.327499e-01 0.273 0 0
Signaling by EGFR R-HSA-177929 4.463714e-01 0.350 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.075657e-01 0.683 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.421848e-01 0.466 0 0
Meiosis R-HSA-1500620 1.022972e-01 0.990 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.617085e-01 0.791 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.832745e-01 0.548 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.595777e-01 0.338 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.894969e-01 0.538 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.282047e-01 0.368 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.777222e-01 0.238 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.627127e-01 0.581 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.235605e-01 0.373 0 0
Extension of Telomeres R-HSA-180786 4.998925e-01 0.301 0 0
DNA Double Strand Break Response R-HSA-5693606 3.795976e-01 0.421 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.165701e-01 0.664 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.076894e-01 0.512 0 0
Frs2-mediated activation R-HSA-170968 3.770546e-01 0.424 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.357465e-01 0.628 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.986322e-01 0.302 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.617085e-01 0.791 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.378970e-01 0.624 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.071677e-01 0.513 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.160975e-01 0.381 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.453717e-01 0.351 0 0
PI3K Cascade R-HSA-109704 3.382633e-01 0.471 0 0
Josephin domain DUBs R-HSA-5689877 5.011085e-01 0.300 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.518508e-01 0.258 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.054618e-01 0.687 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.282047e-01 0.368 0 0
Netrin-1 signaling R-HSA-373752 2.357465e-01 0.628 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.107028e-01 0.508 0 0
EPH-Ephrin signaling R-HSA-2682334 1.198237e-01 0.921 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.894969e-01 0.538 0 0
GAB1 signalosome R-HSA-180292 3.471991e-01 0.459 0 0
MHC class II antigen presentation R-HSA-2132295 5.054032e-01 0.296 0 0
Formation of apoptosome R-HSA-111458 2.378970e-01 0.624 0 0
Regulation of CDH11 function R-HSA-9762292 2.378970e-01 0.624 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.709216e-01 0.431 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.182452e-01 0.497 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.976977e-01 0.526 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.635499e-01 0.579 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.668727e-01 0.574 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.115229e-01 0.386 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.595777e-01 0.338 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.549933e-01 0.593 0 0
Myogenesis R-HSA-525793 3.983933e-01 0.400 0 0
TNF signaling R-HSA-75893 2.123447e-01 0.673 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.162846e-01 0.665 0 0
HIV Life Cycle R-HSA-162587 1.104092e-01 0.957 0 0
IGF1R signaling cascade R-HSA-2428924 1.477346e-01 0.831 0 0
DAP12 signaling R-HSA-2424491 4.975087e-01 0.303 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.687537e-01 0.571 0 0
Dopamine receptors R-HSA-390651 1.826389e-01 0.738 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.295172e-01 0.639 0 0
Adrenoceptors R-HSA-390696 1.720156e-01 0.764 0 0
Sodium/Calcium exchangers R-HSA-425561 1.321852e-01 0.879 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.244108e-01 0.489 0 0
Trafficking of AMPA receptors R-HSA-399719 1.117655e-01 0.952 0 0
NF-kB is activated and signals survival R-HSA-209560 3.071677e-01 0.513 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.421848e-01 0.466 0 0
Regulation of IFNG signaling R-HSA-877312 3.421848e-01 0.466 0 0
Intraflagellar transport R-HSA-5620924 1.947376e-01 0.711 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.080066e-01 0.967 0 0
cGMP effects R-HSA-418457 4.115229e-01 0.386 0 0
Budding and maturation of HIV virion R-HSA-162588 3.465269e-01 0.460 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.235605e-01 0.373 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.274747e-01 0.369 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.854798e-01 0.314 0 0
S Phase R-HSA-69242 3.988250e-01 0.399 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.509654e-01 0.600 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.509654e-01 0.600 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.893044e-01 0.723 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.733154e-01 0.761 0 0
Nuclear RNA decay R-HSA-9930044 1.378443e-01 0.861 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.699673e-01 0.770 0 0
Diseases of programmed cell death R-HSA-9645723 1.972229e-01 0.705 0 0
RMTs methylate histone arginines R-HSA-3214858 2.357465e-01 0.628 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.919156e-01 0.407 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.368980e-01 0.360 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.345422e-01 0.871 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.983933e-01 0.400 0 0
Signaling by FGFR3 R-HSA-5654741 5.288041e-01 0.277 0 0
HIV Infection R-HSA-162906 2.057049e-01 0.687 0 0
Repression of WNT target genes R-HSA-4641265 1.555770e-01 0.808 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.225803e-01 0.912 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.813701e-01 0.741 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.447462e-01 0.264 0 0
Apoptotic factor-mediated response R-HSA-111471 5.713792e-01 0.243 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.695220e-01 0.244 0 0
Signaling by FGFR4 R-HSA-5654743 4.888546e-01 0.311 0 0
G1 Phase R-HSA-69236 3.605344e-01 0.443 0 0
Cyclin D associated events in G1 R-HSA-69231 3.605344e-01 0.443 0 0
Generation of second messenger molecules R-HSA-202433 4.065112e-01 0.391 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.345422e-01 0.871 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.019273e-01 0.695 0 0
GPER1 signaling R-HSA-9634597 4.376355e-01 0.359 0 0
Signalling to ERKs R-HSA-187687 3.033395e-01 0.518 0 0
Signaling by WNT in cancer R-HSA-4791275 3.691951e-01 0.433 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.583015e-01 0.801 0 0
Hedgehog 'on' state R-HSA-5632684 5.695220e-01 0.244 0 0
Signaling by WNT R-HSA-195721 2.918349e-01 0.535 0 0
TCR signaling R-HSA-202403 3.199546e-01 0.495 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.039814e-01 0.394 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.803739e-01 0.744 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.402964e-01 0.853 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.378443e-01 0.861 0 0
MAP2K and MAPK activation R-HSA-5674135 1.088560e-01 0.963 0 0
PTK6 Expression R-HSA-8849473 3.709216e-01 0.431 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.709216e-01 0.431 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.770546e-01 0.424 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.635499e-01 0.579 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.838605e-01 0.547 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.205513e-01 0.494 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.336506e-01 0.363 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.372106e-01 0.359 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.027530e-01 0.395 0 0
Formation of the posterior neural plate R-HSA-9832991 5.405226e-01 0.267 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.794694e-01 0.554 0 0
IRS-mediated signalling R-HSA-112399 4.643343e-01 0.333 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.777222e-01 0.238 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.777222e-01 0.238 0 0
MTOR signalling R-HSA-165159 3.224096e-01 0.492 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.596442e-01 0.338 0 0
Ub-specific processing proteases R-HSA-5689880 4.339692e-01 0.363 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.171755e-01 0.931 0 0
Signaling by Hedgehog R-HSA-5358351 1.133471e-01 0.946 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.701499e-01 0.244 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.746868e-01 0.758 0 0
Opioid Signalling R-HSA-111885 1.710963e-01 0.767 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.894969e-01 0.538 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.635499e-01 0.579 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.675587e-01 0.246 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.378443e-01 0.861 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.713792e-01 0.243 0 0
HSF1-dependent transactivation R-HSA-3371571 1.489430e-01 0.827 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.856940e-01 0.414 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.856940e-01 0.414 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.856940e-01 0.414 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.856940e-01 0.414 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.732009e-01 0.325 0 0
Mitotic Prophase R-HSA-68875 2.174328e-01 0.663 0 0
Signaling by ROBO receptors R-HSA-376176 1.393889e-01 0.856 0 0
Signaling by NOTCH1 R-HSA-1980143 2.059326e-01 0.686 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.722278e-01 0.326 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.319118e-01 0.274 0 0
Host Interactions of HIV factors R-HSA-162909 4.237474e-01 0.373 0 0
Deubiquitination R-HSA-5688426 1.578389e-01 0.802 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.976977e-01 0.526 0 0
DNA Repair R-HSA-73894 3.598992e-01 0.444 0 0
FasL/ CD95L signaling R-HSA-75157 1.375121e-01 0.862 0 0
Polo-like kinase mediated events R-HSA-156711 1.804582e-01 0.744 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.722954e-01 0.565 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.453717e-01 0.351 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.895501e-01 0.310 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.126554e-01 0.384 0 0
Complex III assembly R-HSA-9865881 5.430360e-01 0.265 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.218971e-01 0.282 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.264061e-01 0.370 0 0
Signaling by TGFB family members R-HSA-9006936 2.933762e-01 0.533 0 0
Transmission across Chemical Synapses R-HSA-112315 2.152068e-01 0.667 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.138726e-01 0.944 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.478370e-01 0.459 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.213780e-01 0.283 0 0
Autophagy R-HSA-9612973 1.957913e-01 0.708 0 0
Gene expression (Transcription) R-HSA-74160 2.495368e-01 0.603 0 0
Cellular Senescence R-HSA-2559583 2.844644e-01 0.546 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.117143e-01 0.291 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.482807e-01 0.829 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.321852e-01 0.879 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.031296e-01 0.987 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.421848e-01 0.466 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.850970e-01 0.545 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.115229e-01 0.386 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.442293e-01 0.463 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.983933e-01 0.400 0 0
Vesicle-mediated transport R-HSA-5653656 2.970923e-01 0.527 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.713792e-01 0.243 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.484807e-01 0.261 0 0
RNA Polymerase II Transcription R-HSA-73857 2.233546e-01 0.651 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.117143e-01 0.291 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.608002e-01 0.794 0 0
Insulin receptor signalling cascade R-HSA-74751 4.539211e-01 0.343 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.271745e-01 0.896 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.054032e-01 0.296 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.617085e-01 0.791 0 0
G2/M Checkpoints R-HSA-69481 1.653872e-01 0.781 0 0
Generic Transcription Pathway R-HSA-212436 2.509327e-01 0.600 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.282047e-01 0.368 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.234184e-01 0.909 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.431671e-01 0.844 0 0
Cellular responses to stress R-HSA-2262752 4.912608e-01 0.309 0 0
G-protein beta:gamma signalling R-HSA-397795 5.675587e-01 0.246 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.954212e-01 0.403 0 0
Co-stimulation by CD28 R-HSA-389356 1.947376e-01 0.711 0 0
Glycogen metabolism R-HSA-8982491 5.672815e-01 0.246 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.991788e-01 0.524 0 0
Signaling by Erythropoietin R-HSA-9006335 4.732009e-01 0.325 0 0
FLT3 Signaling R-HSA-9607240 9.874759e-02 1.005 0 0
Cellular responses to stimuli R-HSA-8953897 4.061979e-01 0.391 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.375121e-01 0.862 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.216558e-01 0.493 0 0
Regulation of PTEN localization R-HSA-8948747 1.413539e-01 0.850 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.295172e-01 0.639 0 0
Co-stimulation by ICOS R-HSA-9927354 1.720156e-01 0.764 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.043379e-01 0.690 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.039814e-01 0.394 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.039814e-01 0.394 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.378970e-01 0.624 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.611378e-01 0.583 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.611378e-01 0.583 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.709216e-01 0.431 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.709216e-01 0.431 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.709216e-01 0.431 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.763199e-01 0.322 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.763199e-01 0.322 0 0
MET interacts with TNS proteins R-HSA-8875513 4.763199e-01 0.322 0 0
Smooth Muscle Contraction R-HSA-445355 1.037832e-01 0.984 0 0
Downstream signal transduction R-HSA-186763 2.070647e-01 0.684 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.160975e-01 0.381 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.043270e-01 0.690 0 0
mTORC1-mediated signalling R-HSA-166208 2.976977e-01 0.526 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.796542e-01 0.553 0 0
Alanine metabolism R-HSA-8964540 5.398825e-01 0.268 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.398825e-01 0.268 0 0
Transmission across Electrical Synapses R-HSA-112307 5.398825e-01 0.268 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.731182e-01 0.428 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.442293e-01 0.463 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.549052e-01 0.594 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.784179e-01 0.320 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.372106e-01 0.359 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.105106e-01 0.292 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.405226e-01 0.267 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 5.430360e-01 0.265 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.777222e-01 0.238 0 0
Signaling by AXIN mutants R-HSA-4839735 5.777222e-01 0.238 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.777222e-01 0.238 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.447462e-01 0.264 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.713792e-01 0.243 0 0
Apoptosis R-HSA-109581 1.008458e-01 0.996 0 0
Macroautophagy R-HSA-1632852 3.131518e-01 0.504 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.251642e-01 0.648 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.251642e-01 0.648 0 0
Cell junction organization R-HSA-446728 2.552911e-01 0.593 0 0
FLT3 signaling in disease R-HSA-9682385 4.818487e-01 0.317 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.869209e-01 0.728 0 0
Programmed Cell Death R-HSA-5357801 1.183025e-01 0.927 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.463714e-01 0.350 0 0
Activation of BH3-only proteins R-HSA-114452 4.975087e-01 0.303 0 0
Signaling by PTK6 R-HSA-8848021 1.375570e-01 0.862 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.375570e-01 0.862 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.674877e-01 0.246 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.856940e-01 0.414 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.166389e-01 0.287 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.288041e-01 0.277 0 0
Selective autophagy R-HSA-9663891 1.330430e-01 0.876 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.959698e-01 0.529 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.855843e-01 0.731 0 0
Signaling by ERBB4 R-HSA-1236394 4.926535e-01 0.307 0 0
Adherens junctions interactions R-HSA-418990 4.370555e-01 0.359 0 0
Cell-Cell communication R-HSA-1500931 1.109989e-01 0.955 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.478370e-01 0.459 0 0
Reproduction R-HSA-1474165 1.982628e-01 0.703 0 0
Interleukin-6 signaling R-HSA-1059683 3.770546e-01 0.424 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.709216e-01 0.431 0 0
Protein methylation R-HSA-8876725 4.453717e-01 0.351 0 0
Amine ligand-binding receptors R-HSA-375280 5.089686e-01 0.293 0 0
GPVI-mediated activation cascade R-HSA-114604 1.980231e-01 0.703 0 0
Signaling by TGFBR3 R-HSA-9839373 1.676603e-01 0.776 0 0
Regulated Necrosis R-HSA-5218859 3.957720e-01 0.403 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.292110e-01 0.640 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.431671e-01 0.844 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.398825e-01 0.268 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.011085e-01 0.300 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.732009e-01 0.325 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.730742e-01 0.564 0 0
Negative regulation of FLT3 R-HSA-9706369 4.784179e-01 0.320 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.713792e-01 0.243 0 0
Ion transport by P-type ATPases R-HSA-936837 3.315831e-01 0.479 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.975087e-01 0.303 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.721894e-01 0.429 0 0
Interleukin-2 family signaling R-HSA-451927 5.672815e-01 0.246 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.772397e-01 0.751 0 0
Signaling by LTK R-HSA-9842663 1.555770e-01 0.808 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.770580e-01 0.557 0 0
Gap junction trafficking R-HSA-190828 1.425394e-01 0.846 0 0
RAB geranylgeranylation R-HSA-8873719 1.094395e-01 0.961 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.770546e-01 0.424 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.635499e-01 0.579 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.398825e-01 0.268 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.990708e-01 0.399 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.605676e-01 0.337 0 0
Inositol phosphate metabolism R-HSA-1483249 1.897505e-01 0.722 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.675587e-01 0.246 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.548446e-01 0.810 0 0
Signaling by SCF-KIT R-HSA-1433557 2.198195e-01 0.658 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.856940e-01 0.414 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.177690e-01 0.662 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.341129e-01 0.476 0 0
Interleukin-1 family signaling R-HSA-446652 2.867669e-01 0.542 0 0
TGFBR3 expression R-HSA-9839394 2.162846e-01 0.665 0 0
G0 and Early G1 R-HSA-1538133 1.244461e-01 0.905 0 0
Integration of provirus R-HSA-162592 5.777222e-01 0.238 0 0
Interleukin-15 signaling R-HSA-8983432 3.421848e-01 0.466 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.415290e-01 0.266 0 0
Phospholipid metabolism R-HSA-1483257 5.685567e-01 0.245 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.378443e-01 0.861 0 0
DSCAM interactions R-HSA-376172 4.039814e-01 0.394 0 0
Synthesis of PI R-HSA-1483226 2.722954e-01 0.565 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.378443e-01 0.861 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.378443e-01 0.861 0 0
Gap junction trafficking and regulation R-HSA-157858 2.089507e-01 0.680 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.490040e-01 0.604 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.595777e-01 0.338 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.398825e-01 0.268 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.336506e-01 0.363 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.011085e-01 0.300 0 0
Activation of SMO R-HSA-5635838 4.784179e-01 0.320 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.732009e-01 0.325 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.105106e-01 0.292 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.405226e-01 0.267 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.643955e-01 0.438 0 0
Glucose metabolism R-HSA-70326 2.585765e-01 0.587 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.818538e-01 0.317 0 0
Signaling by ALK R-HSA-201556 1.473775e-01 0.832 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.254874e-01 0.901 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.272820e-01 0.369 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.720156e-01 0.764 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.233157e-01 0.909 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.053412e-01 0.977 0 0
Signaling by Interleukins R-HSA-449147 2.866795e-01 0.543 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.378970e-01 0.624 0 0
Histamine receptors R-HSA-390650 4.763199e-01 0.322 0 0
Tie2 Signaling R-HSA-210993 3.471991e-01 0.459 0 0
Nuclear import of Rev protein R-HSA-180746 2.832745e-01 0.548 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.595777e-01 0.338 0 0
PECAM1 interactions R-HSA-210990 5.405226e-01 0.267 0 0
Interleukin-7 signaling R-HSA-1266695 3.731182e-01 0.428 0 0
Syndecan interactions R-HSA-3000170 3.226586e-01 0.491 0 0
Formation of the anterior neural plate R-HSA-9823739 4.453717e-01 0.351 0 0
Diseases of DNA repair R-HSA-9675135 1.676603e-01 0.776 0 0
Formation of the nephric duct R-HSA-9830364 5.686704e-01 0.245 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.096049e-01 0.960 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.470182e-01 0.833 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.039814e-01 0.394 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.709216e-01 0.431 0 0
Gap junction assembly R-HSA-190861 1.666841e-01 0.778 0 0
Sodium/Proton exchangers R-HSA-425986 4.160975e-01 0.381 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.398825e-01 0.268 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.398825e-01 0.268 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.011085e-01 0.300 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.065112e-01 0.391 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.272820e-01 0.369 0 0
Bicarbonate transporters R-HSA-425381 5.405226e-01 0.267 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.461052e-01 0.263 0 0
Signaling by ALK in cancer R-HSA-9700206 1.470182e-01 0.833 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.179854e-01 0.928 0 0
IRE1alpha activates chaperones R-HSA-381070 3.312006e-01 0.480 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.595777e-01 0.338 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.666841e-01 0.778 0 0
Metal ion SLC transporters R-HSA-425410 4.376355e-01 0.359 0 0
Interleukin-12 family signaling R-HSA-447115 3.630706e-01 0.440 0 0
Interleukin-2 signaling R-HSA-9020558 5.405226e-01 0.267 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.770580e-01 0.557 0 0
Leukotriene receptors R-HSA-391906 3.244108e-01 0.489 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.709216e-01 0.431 0 0
OAS antiviral response R-HSA-8983711 3.421848e-01 0.466 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.595777e-01 0.338 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.618544e-01 0.335 0 0
PKR-mediated signaling R-HSA-9833482 3.536850e-01 0.451 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.583015e-01 0.801 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.471991e-01 0.459 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.336506e-01 0.363 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.713792e-01 0.243 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.490467e-01 0.457 0 0
Interleukin-12 signaling R-HSA-9020591 2.963906e-01 0.528 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 4.895501e-01 0.310 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.713792e-01 0.243 0 0
Signaling by FGFR2 R-HSA-5654738 5.854178e-01 0.233 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.854178e-01 0.233 0 0
Signaling by FGFR1 R-HSA-5654736 5.855621e-01 0.232 0 0
Interferon Signaling R-HSA-913531 5.891981e-01 0.230 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.897685e-01 0.229 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.902950e-01 0.229 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.934837e-01 0.227 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.934837e-01 0.227 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.934837e-01 0.227 0 0
Metalloprotease DUBs R-HSA-5689901 5.934837e-01 0.227 0 0
Cell-cell junction organization R-HSA-421270 5.944912e-01 0.226 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.957332e-01 0.225 0 0
Defective CYP17A1 causes AH5 R-HSA-5579028 5.957332e-01 0.225 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.957332e-01 0.225 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.957332e-01 0.225 0 0
Activation of AKT2 R-HSA-165158 5.957332e-01 0.225 0 0
PTK6 Down-Regulation R-HSA-8849472 5.957332e-01 0.225 0 0
Activation of C3 and C5 R-HSA-174577 5.957332e-01 0.225 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.957332e-01 0.225 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.957332e-01 0.225 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.957332e-01 0.225 0 0
Inositol transporters R-HSA-429593 5.957332e-01 0.225 0 0
Co-inhibition by BTLA R-HSA-9927353 5.957332e-01 0.225 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.957332e-01 0.225 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.957332e-01 0.225 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.957332e-01 0.225 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.999913e-01 0.222 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.999913e-01 0.222 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.999913e-01 0.222 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.999913e-01 0.222 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.003852e-01 0.222 0 0
Integration of energy metabolism R-HSA-163685 6.015212e-01 0.221 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.025802e-01 0.220 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.046372e-01 0.219 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.046372e-01 0.219 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.073417e-01 0.217 0 0
Intra-Golgi traffic R-HSA-6811438 6.073417e-01 0.217 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.126640e-01 0.213 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.126640e-01 0.213 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.126640e-01 0.213 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.126640e-01 0.213 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.126640e-01 0.213 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.126640e-01 0.213 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.146578e-01 0.211 0 0
Signaling by FGFR in disease R-HSA-1226099 6.158519e-01 0.211 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.174294e-01 0.209 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.174294e-01 0.209 0 0
Packaging Of Telomere Ends R-HSA-171306 6.174294e-01 0.209 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.174294e-01 0.209 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.174294e-01 0.209 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.174294e-01 0.209 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.174294e-01 0.209 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.273174e-01 0.203 0 0
Signal transduction by L1 R-HSA-445144 6.273174e-01 0.203 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.307262e-01 0.200 0 0
PERK regulates gene expression R-HSA-381042 6.322284e-01 0.199 0 0
PTEN Regulation R-HSA-6807070 6.344548e-01 0.198 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.360807e-01 0.196 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.369136e-01 0.196 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.369136e-01 0.196 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 6.404721e-01 0.193 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.404721e-01 0.193 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.428489e-01 0.192 0 0
Plus-strand DNA synthesis R-HSA-164525 6.448075e-01 0.191 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.448075e-01 0.191 0 0
PDE3B signalling R-HSA-165160 6.448075e-01 0.191 0 0
PKB-mediated events R-HSA-109703 6.448075e-01 0.191 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.448075e-01 0.191 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.448075e-01 0.191 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.448075e-01 0.191 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.448075e-01 0.191 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.448075e-01 0.191 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.448075e-01 0.191 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.448075e-01 0.191 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.448075e-01 0.191 0 0
NGF-independant TRKA activation R-HSA-187024 6.448075e-01 0.191 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.448075e-01 0.191 0 0
Phosphorylation of Emi1 R-HSA-176417 6.448075e-01 0.191 0 0
Ceramide signalling R-HSA-193681 6.448075e-01 0.191 0 0
Formation of the Editosome R-HSA-75094 6.448075e-01 0.191 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.448075e-01 0.191 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.448075e-01 0.191 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.452741e-01 0.190 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.453481e-01 0.190 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.453481e-01 0.190 0 0
Formation of axial mesoderm R-HSA-9796292 6.453481e-01 0.190 0 0
Chylomicron remodeling R-HSA-8963901 6.453481e-01 0.190 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.453481e-01 0.190 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.453481e-01 0.190 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.453481e-01 0.190 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.453481e-01 0.190 0 0
Processing of SMDT1 R-HSA-8949664 6.453481e-01 0.190 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.453481e-01 0.190 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.453481e-01 0.190 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.453481e-01 0.190 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.453481e-01 0.190 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.476313e-01 0.189 0 0
GABA receptor activation R-HSA-977443 6.521568e-01 0.186 0 0
Triglyceride catabolism R-HSA-163560 6.524198e-01 0.185 0 0
RUNX2 regulates bone development R-HSA-8941326 6.524198e-01 0.185 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.533281e-01 0.185 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.533281e-01 0.185 0 0
Basigin interactions R-HSA-210991 6.533281e-01 0.185 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.533281e-01 0.185 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.540344e-01 0.184 0 0
mRNA Capping R-HSA-72086 6.625865e-01 0.179 0 0
DNA methylation R-HSA-5334118 6.625865e-01 0.179 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.625865e-01 0.179 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.625865e-01 0.179 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.626898e-01 0.179 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.632278e-01 0.178 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.669287e-01 0.176 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.677958e-01 0.175 0 0
Aquaporin-mediated transport R-HSA-445717 6.677958e-01 0.175 0 0
MAP kinase activation R-HSA-450294 6.677958e-01 0.175 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.718904e-01 0.173 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.718904e-01 0.173 0 0
Cleavage of the damaged purine R-HSA-110331 6.718904e-01 0.173 0 0
RNA Polymerase I Transcription R-HSA-73864 6.734510e-01 0.172 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.735374e-01 0.172 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.735374e-01 0.172 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.758077e-01 0.170 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.758077e-01 0.170 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.758077e-01 0.170 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.758077e-01 0.170 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.758077e-01 0.170 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.758077e-01 0.170 0 0
Prolactin receptor signaling R-HSA-1170546 6.758077e-01 0.170 0 0
Physiological factors R-HSA-5578768 6.758077e-01 0.170 0 0
Regulation of KIT signaling R-HSA-1433559 6.758077e-01 0.170 0 0
HDL assembly R-HSA-8963896 6.758077e-01 0.170 0 0
Signal regulatory protein family interactions R-HSA-391160 6.758077e-01 0.170 0 0
Zinc transporters R-HSA-435354 6.758077e-01 0.170 0 0
P2Y receptors R-HSA-417957 6.758077e-01 0.170 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.780104e-01 0.169 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.780104e-01 0.169 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.780104e-01 0.169 0 0
Assembly Of The HIV Virion R-HSA-175474 6.780104e-01 0.169 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.780104e-01 0.169 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.795476e-01 0.168 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.809043e-01 0.167 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.837563e-01 0.165 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.857559e-01 0.164 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.857559e-01 0.164 0 0
Stimuli-sensing channels R-HSA-2672351 6.857559e-01 0.164 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.879271e-01 0.162 0 0
Uncoating of the HIV Virion R-HSA-162585 6.879271e-01 0.162 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.879271e-01 0.162 0 0
Hydrolysis of LPE R-HSA-1483152 6.879271e-01 0.162 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.879271e-01 0.162 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.879271e-01 0.162 0 0
Neurofascin interactions R-HSA-447043 6.879271e-01 0.162 0 0
NADPH regeneration R-HSA-389542 6.879271e-01 0.162 0 0
Signaling by LTK in cancer R-HSA-9842640 6.879271e-01 0.162 0 0
Nef and signal transduction R-HSA-164944 6.879271e-01 0.162 0 0
Depurination R-HSA-73927 6.906262e-01 0.161 0 0
MET promotes cell motility R-HSA-8875878 6.906262e-01 0.161 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.906262e-01 0.161 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.918823e-01 0.160 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.918823e-01 0.160 0 0
Signaling by MET R-HSA-6806834 7.002498e-01 0.155 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.002806e-01 0.155 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.002806e-01 0.155 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.013652e-01 0.154 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.013652e-01 0.154 0 0
Signaling by KIT in disease R-HSA-9669938 7.013652e-01 0.154 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.039319e-01 0.152 0 0
EGFR downregulation R-HSA-182971 7.039734e-01 0.152 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.039734e-01 0.152 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.039734e-01 0.152 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.041010e-01 0.152 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.041010e-01 0.152 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.041010e-01 0.152 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.041010e-01 0.152 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.041010e-01 0.152 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.041010e-01 0.152 0 0
Translesion synthesis by REV1 R-HSA-110312 7.041010e-01 0.152 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.041010e-01 0.152 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.041010e-01 0.152 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.041010e-01 0.152 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.041010e-01 0.152 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.041010e-01 0.152 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.041010e-01 0.152 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.041010e-01 0.152 0 0
HDACs deacetylate histones R-HSA-3214815 7.050199e-01 0.152 0 0
Signaling by NOTCH3 R-HSA-9012852 7.050199e-01 0.152 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.120895e-01 0.147 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.141239e-01 0.146 0 0
Mitochondrial biogenesis R-HSA-1592230 7.157581e-01 0.145 0 0
Ca2+ pathway R-HSA-4086398 7.189684e-01 0.143 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.234054e-01 0.141 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.234054e-01 0.141 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.234054e-01 0.141 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.234054e-01 0.141 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.234054e-01 0.141 0 0
Interleukin-20 family signaling R-HSA-8854691 7.234054e-01 0.141 0 0
Metabolism of RNA R-HSA-8953854 7.254174e-01 0.139 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.258143e-01 0.139 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.258143e-01 0.139 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.258143e-01 0.139 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.258143e-01 0.139 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.258143e-01 0.139 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.258143e-01 0.139 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.258143e-01 0.139 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.258143e-01 0.139 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.258143e-01 0.139 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.258143e-01 0.139 0 0
VLDL clearance R-HSA-8964046 7.258143e-01 0.139 0 0
Activation of TRKA receptors R-HSA-187015 7.258143e-01 0.139 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.258143e-01 0.139 0 0
Maturation of replicase proteins R-HSA-9694301 7.258143e-01 0.139 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.258626e-01 0.139 0 0
Diseases of Immune System R-HSA-5260271 7.258626e-01 0.139 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.258626e-01 0.139 0 0
G alpha (s) signalling events R-HSA-418555 7.271075e-01 0.138 0 0
HCMV Early Events R-HSA-9609690 7.301843e-01 0.137 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 7.303052e-01 0.136 0 0
Translesion synthesis by POLI R-HSA-5656121 7.303052e-01 0.136 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.303052e-01 0.136 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.303052e-01 0.136 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.303052e-01 0.136 0 0
Differentiation of T cells R-HSA-9945266 7.303052e-01 0.136 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.303052e-01 0.136 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.303052e-01 0.136 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.303052e-01 0.136 0 0
Ion channel transport R-HSA-983712 7.398956e-01 0.131 0 0
Cardiogenesis R-HSA-9733709 7.415533e-01 0.130 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.415533e-01 0.130 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.423597e-01 0.129 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.423597e-01 0.129 0 0
Platelet degranulation R-HSA-114608 7.424927e-01 0.129 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.435331e-01 0.129 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.441535e-01 0.128 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.441535e-01 0.128 0 0
Interleukin-6 family signaling R-HSA-6783589 7.441535e-01 0.128 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.441535e-01 0.128 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.483372e-01 0.126 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.486433e-01 0.126 0 0
Signaling by FGFR R-HSA-190236 7.491474e-01 0.125 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.491474e-01 0.125 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.491474e-01 0.125 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.491474e-01 0.125 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.545103e-01 0.122 0 0
Translesion synthesis by POLK R-HSA-5655862 7.545103e-01 0.122 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.545103e-01 0.122 0 0
Disorders of Developmental Biology R-HSA-9675151 7.545103e-01 0.122 0 0
Passive transport by Aquaporins R-HSA-432047 7.545103e-01 0.122 0 0
Platelet homeostasis R-HSA-418346 7.546145e-01 0.122 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.565704e-01 0.121 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.581137e-01 0.120 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.581137e-01 0.120 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.581137e-01 0.120 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.589330e-01 0.120 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.591037e-01 0.120 0 0
Minus-strand DNA synthesis R-HSA-164516 7.591037e-01 0.120 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.591037e-01 0.120 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.591037e-01 0.120 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.591037e-01 0.120 0 0
MET receptor recycling R-HSA-8875656 7.591037e-01 0.120 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.591037e-01 0.120 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.591037e-01 0.120 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.591037e-01 0.120 0 0
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-211957 7.591037e-01 0.120 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.591037e-01 0.120 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.591037e-01 0.120 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.591037e-01 0.120 0 0
Interleukin-9 signaling R-HSA-8985947 7.591037e-01 0.120 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.591037e-01 0.120 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.591037e-01 0.120 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.591037e-01 0.120 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.591037e-01 0.120 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.591037e-01 0.120 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.591037e-01 0.120 0 0
Alpha-defensins R-HSA-1462054 7.591037e-01 0.120 0 0
RSK activation R-HSA-444257 7.591037e-01 0.120 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.593387e-01 0.120 0 0
Regulation of beta-cell development R-HSA-186712 7.617247e-01 0.118 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.636403e-01 0.117 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.636403e-01 0.117 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.636403e-01 0.117 0 0
G protein gated Potassium channels R-HSA-1296059 7.636403e-01 0.117 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.636403e-01 0.117 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.646409e-01 0.117 0 0
Signaling by Insulin receptor R-HSA-74752 7.654512e-01 0.116 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.694907e-01 0.114 0 0
Activation of GABAB receptors R-HSA-991365 7.731326e-01 0.112 0 0
GABA B receptor activation R-HSA-977444 7.731326e-01 0.112 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.731326e-01 0.112 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.731326e-01 0.112 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.743840e-01 0.111 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.753923e-01 0.110 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.753923e-01 0.110 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.753923e-01 0.110 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.768154e-01 0.110 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.768154e-01 0.110 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.768154e-01 0.110 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.819030e-01 0.107 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.819030e-01 0.107 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.838438e-01 0.106 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.864210e-01 0.104 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.869328e-01 0.104 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.869328e-01 0.104 0 0
Defective pyroptosis R-HSA-9710421 7.874271e-01 0.104 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.878184e-01 0.104 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.878184e-01 0.104 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.883531e-01 0.103 0 0
Unwinding of DNA R-HSA-176974 7.883531e-01 0.103 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.883531e-01 0.103 0 0
Interleukin-21 signaling R-HSA-9020958 7.883531e-01 0.103 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.883531e-01 0.103 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.883531e-01 0.103 0 0
mRNA Editing R-HSA-75072 7.883531e-01 0.103 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.883531e-01 0.103 0 0
Interleukin-1 processing R-HSA-448706 7.883531e-01 0.103 0 0
Interleukin-17 signaling R-HSA-448424 7.884060e-01 0.103 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.905074e-01 0.102 0 0
Oncogene Induced Senescence R-HSA-2559585 7.909513e-01 0.102 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.973250e-01 0.098 0 0
Activated point mutants of FGFR2 R-HSA-2033519 7.973250e-01 0.098 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 7.973250e-01 0.098 0 0
Platelet sensitization by LDL R-HSA-432142 7.973250e-01 0.098 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.973250e-01 0.098 0 0
Nephron development R-HSA-9831926 7.973250e-01 0.098 0 0
Signaling by PDGF R-HSA-186797 7.987634e-01 0.098 0 0
tRNA processing in the nucleus R-HSA-6784531 7.987634e-01 0.098 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.995309e-01 0.097 0 0
DAP12 interactions R-HSA-2172127 8.010106e-01 0.096 0 0
Peptide chain elongation R-HSA-156902 8.029815e-01 0.095 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.037242e-01 0.095 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.056336e-01 0.094 0 0
HSF1 activation R-HSA-3371511 8.056336e-01 0.094 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.100874e-01 0.091 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.102102e-01 0.091 0 0
Translation initiation complex formation R-HSA-72649 8.111182e-01 0.091 0 0
Signaling by NOTCH R-HSA-157118 8.124952e-01 0.090 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.133429e-01 0.090 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.133429e-01 0.090 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.138991e-01 0.089 0 0
Binding and entry of HIV virion R-HSA-173107 8.140526e-01 0.089 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.140526e-01 0.089 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.140526e-01 0.089 0 0
2-LTR circle formation R-HSA-164843 8.140526e-01 0.089 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.140526e-01 0.089 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.140526e-01 0.089 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.140526e-01 0.089 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.140526e-01 0.089 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.140526e-01 0.089 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.140526e-01 0.089 0 0
Signal attenuation R-HSA-74749 8.140526e-01 0.089 0 0
CASP4 inflammasome assembly R-HSA-9948001 8.140526e-01 0.089 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.140526e-01 0.089 0 0
PI3K/AKT activation R-HSA-198203 8.140526e-01 0.089 0 0
Arachidonate production from DAG R-HSA-426048 8.140526e-01 0.089 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.140526e-01 0.089 0 0
Interleukin-27 signaling R-HSA-9020956 8.140526e-01 0.089 0 0
Maturation of spike protein R-HSA-9683686 8.140526e-01 0.089 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.140526e-01 0.089 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.140526e-01 0.089 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.140526e-01 0.089 0 0
Signaling by Leptin R-HSA-2586552 8.140526e-01 0.089 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.144237e-01 0.089 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.149287e-01 0.089 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.149287e-01 0.089 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.161462e-01 0.088 0 0
Translesion Synthesis by POLH R-HSA-110320 8.161462e-01 0.088 0 0
Regulation of signaling by CBL R-HSA-912631 8.161462e-01 0.088 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.161462e-01 0.088 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.161462e-01 0.088 0 0
The NLRP3 inflammasome R-HSA-844456 8.161462e-01 0.088 0 0
Other interleukin signaling R-HSA-449836 8.161462e-01 0.088 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.161462e-01 0.088 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.161462e-01 0.088 0 0
Co-inhibition by PD-1 R-HSA-389948 8.183951e-01 0.087 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.188695e-01 0.087 0 0
Downstream TCR signaling R-HSA-202424 8.218182e-01 0.085 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.261102e-01 0.083 0 0
GPCR downstream signalling R-HSA-388396 8.271488e-01 0.082 0 0
Neutrophil degranulation R-HSA-6798695 8.276445e-01 0.082 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.297869e-01 0.081 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.297869e-01 0.081 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.297869e-01 0.081 0 0
Regulation of insulin secretion R-HSA-422356 8.317275e-01 0.080 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.330950e-01 0.079 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.333866e-01 0.079 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.333866e-01 0.079 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.333866e-01 0.079 0 0
Glycogen synthesis R-HSA-3322077 8.333866e-01 0.079 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.333866e-01 0.079 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.333866e-01 0.079 0 0
Signaling by NODAL R-HSA-1181150 8.333866e-01 0.079 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.333866e-01 0.079 0 0
Negative regulation of MET activity R-HSA-6807004 8.333866e-01 0.079 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.333866e-01 0.079 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.335189e-01 0.079 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.365459e-01 0.078 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.365459e-01 0.078 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.366328e-01 0.077 0 0
vRNA Synthesis R-HSA-192814 8.366328e-01 0.077 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.366328e-01 0.077 0 0
vRNP Assembly R-HSA-192905 8.366328e-01 0.077 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.366328e-01 0.077 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.366328e-01 0.077 0 0
Chylomicron assembly R-HSA-8963888 8.366328e-01 0.077 0 0
Suppression of apoptosis R-HSA-9635465 8.366328e-01 0.077 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.376633e-01 0.077 0 0
DNA Replication R-HSA-69306 8.385173e-01 0.076 0 0
Gene Silencing by RNA R-HSA-211000 8.409317e-01 0.075 0 0
Developmental Biology R-HSA-1266738 8.433660e-01 0.074 0 0
Regulation of CDH1 Function R-HSA-9764561 8.438919e-01 0.074 0 0
Pentose phosphate pathway R-HSA-71336 8.446933e-01 0.073 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.446933e-01 0.073 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.491524e-01 0.071 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.491524e-01 0.071 0 0
Lagging Strand Synthesis R-HSA-69186 8.491524e-01 0.071 0 0
Signalling to RAS R-HSA-167044 8.491524e-01 0.071 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.512058e-01 0.070 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.537337e-01 0.069 0 0
Interleukin-1 signaling R-HSA-9020702 8.553343e-01 0.068 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.561511e-01 0.067 0 0
Attenuation phase R-HSA-3371568 8.561511e-01 0.067 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.564463e-01 0.067 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.564721e-01 0.067 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.564721e-01 0.067 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.564721e-01 0.067 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.564721e-01 0.067 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.564721e-01 0.067 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.564721e-01 0.067 0 0
Mitochondrial protein degradation R-HSA-9837999 8.628883e-01 0.064 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.635475e-01 0.064 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.635475e-01 0.064 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.635475e-01 0.064 0 0
Toll-like Receptor Cascades R-HSA-168898 8.648650e-01 0.063 0 0
HCMV Infection R-HSA-9609646 8.651753e-01 0.063 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.668810e-01 0.062 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.668810e-01 0.062 0 0
DNA strand elongation R-HSA-69190 8.683515e-01 0.061 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.685858e-01 0.061 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.718891e-01 0.060 0 0
Potential therapeutics for SARS R-HSA-9679191 8.730795e-01 0.059 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.739032e-01 0.059 0 0
Polymerase switching R-HSA-69091 8.739032e-01 0.059 0 0
Leading Strand Synthesis R-HSA-69109 8.739032e-01 0.059 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.739032e-01 0.059 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.739032e-01 0.059 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.739032e-01 0.059 0 0
Interleukin-35 Signalling R-HSA-8984722 8.739032e-01 0.059 0 0
MET activates RAS signaling R-HSA-8851805 8.739032e-01 0.059 0 0
Proline catabolism R-HSA-70688 8.739032e-01 0.059 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.739032e-01 0.059 0 0
Disorders of Nervous System Development R-HSA-9697154 8.739032e-01 0.059 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.739032e-01 0.059 0 0
Pervasive developmental disorders R-HSA-9005895 8.739032e-01 0.059 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.739032e-01 0.059 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.739032e-01 0.059 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.739032e-01 0.059 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.739032e-01 0.059 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.762558e-01 0.057 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.766722e-01 0.057 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.766722e-01 0.057 0 0
LDL clearance R-HSA-8964038 8.766722e-01 0.057 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.766722e-01 0.057 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.769157e-01 0.057 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.769157e-01 0.057 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.770423e-01 0.057 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.777224e-01 0.057 0 0
Hemostasis R-HSA-109582 8.801209e-01 0.055 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.862882e-01 0.052 0 0
Depyrimidination R-HSA-73928 8.862882e-01 0.052 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.863123e-01 0.052 0 0
Mitochondrial protein import R-HSA-1268020 8.881219e-01 0.052 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.881219e-01 0.052 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.881219e-01 0.052 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.886226e-01 0.051 0 0
Growth hormone receptor signaling R-HSA-982772 8.886226e-01 0.051 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.886226e-01 0.051 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.892182e-01 0.051 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.892182e-01 0.051 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.892182e-01 0.051 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.892182e-01 0.051 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.892182e-01 0.051 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.892182e-01 0.051 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.892182e-01 0.051 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.892182e-01 0.051 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.892182e-01 0.051 0 0
Maturation of nucleoprotein R-HSA-9683610 8.892182e-01 0.051 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.892182e-01 0.051 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.895720e-01 0.051 0 0
Influenza Infection R-HSA-168255 8.914861e-01 0.050 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.925524e-01 0.049 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.931505e-01 0.049 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.943788e-01 0.048 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.951905e-01 0.048 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.978044e-01 0.047 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.979740e-01 0.047 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.989887e-01 0.046 0 0
Mitophagy R-HSA-5205647 8.989887e-01 0.046 0 0
Signaling by NOTCH2 R-HSA-1980145 8.989887e-01 0.046 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.994905e-01 0.046 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.994905e-01 0.046 0 0
Adaptive Immune System R-HSA-1280218 9.011227e-01 0.045 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.019457e-01 0.045 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.026739e-01 0.044 0 0
Removal of the Flap Intermediate R-HSA-69166 9.026739e-01 0.044 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.026739e-01 0.044 0 0
Hydrolysis of LPC R-HSA-1483115 9.026739e-01 0.044 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.026739e-01 0.044 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.026739e-01 0.044 0 0
Biosynthesis of protectins R-HSA-9018681 9.026739e-01 0.044 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.026739e-01 0.044 0 0
Malate-aspartate shuttle R-HSA-9856872 9.026739e-01 0.044 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.026739e-01 0.044 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.026739e-01 0.044 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.031781e-01 0.044 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.081979e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.091777e-01 0.041 0 0
Tight junction interactions R-HSA-420029 9.093623e-01 0.041 0 0
Laminin interactions R-HSA-3000157 9.093623e-01 0.041 0 0
Nucleosome assembly R-HSA-774815 9.107602e-01 0.041 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.107602e-01 0.041 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.107602e-01 0.041 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.107602e-01 0.041 0 0
Gastrulation R-HSA-9758941 9.118723e-01 0.040 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.136413e-01 0.039 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.144960e-01 0.039 0 0
Erythropoietin activates RAS R-HSA-9027284 9.144960e-01 0.039 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.144960e-01 0.039 0 0
Signaling by Activin R-HSA-1502540 9.144960e-01 0.039 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.144960e-01 0.039 0 0
Biotin transport and metabolism R-HSA-196780 9.144960e-01 0.039 0 0
Other semaphorin interactions R-HSA-416700 9.144960e-01 0.039 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.144960e-01 0.039 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.144960e-01 0.039 0 0
DNA Damage Reversal R-HSA-73942 9.144960e-01 0.039 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.148296e-01 0.039 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.156735e-01 0.038 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.156735e-01 0.038 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.156735e-01 0.038 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.156790e-01 0.038 0 0
Developmental Cell Lineages R-HSA-9734767 9.159034e-01 0.038 0 0
UCH proteinases R-HSA-5689603 9.162545e-01 0.038 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.172548e-01 0.038 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.178090e-01 0.037 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.183196e-01 0.037 0 0
Urea cycle R-HSA-70635 9.183196e-01 0.037 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.183196e-01 0.037 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.183196e-01 0.037 0 0
Kidney development R-HSA-9830369 9.212288e-01 0.036 0 0
Degradation of AXIN R-HSA-4641257 9.230453e-01 0.035 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.230453e-01 0.035 0 0
Degradation of DVL R-HSA-4641258 9.230453e-01 0.035 0 0
NCAM1 interactions R-HSA-419037 9.230453e-01 0.035 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.239075e-01 0.034 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.243552e-01 0.034 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.246993e-01 0.034 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.248826e-01 0.034 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.248826e-01 0.034 0 0
Killing mechanisms R-HSA-9664420 9.248826e-01 0.034 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.248826e-01 0.034 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.248826e-01 0.034 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.248826e-01 0.034 0 0
Cristae formation R-HSA-8949613 9.264390e-01 0.033 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.264390e-01 0.033 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.264390e-01 0.033 0 0
Signaling by BMP R-HSA-201451 9.264390e-01 0.033 0 0
Insulin processing R-HSA-264876 9.264390e-01 0.033 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.264390e-01 0.033 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.264390e-01 0.033 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.269721e-01 0.033 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.270069e-01 0.033 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.276791e-01 0.033 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.292542e-01 0.032 0 0
Eukaryotic Translation Termination R-HSA-72764 9.292542e-01 0.032 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.298177e-01 0.032 0 0
Elastic fibre formation R-HSA-1566948 9.298177e-01 0.032 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.304285e-01 0.031 0 0
Cellular response to chemical stress R-HSA-9711123 9.307398e-01 0.031 0 0
Triglyceride metabolism R-HSA-8979227 9.330914e-01 0.030 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.330914e-01 0.030 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.337917e-01 0.030 0 0
Inflammasomes R-HSA-622312 9.337917e-01 0.030 0 0
Pyroptosis R-HSA-5620971 9.337917e-01 0.030 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.340081e-01 0.030 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.340081e-01 0.030 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.340081e-01 0.030 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.340081e-01 0.030 0 0
Phase 2 - plateau phase R-HSA-5576893 9.340081e-01 0.030 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.340081e-01 0.030 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.340081e-01 0.030 0 0
Galactose catabolism R-HSA-70370 9.340081e-01 0.030 0 0
Coenzyme A biosynthesis R-HSA-196783 9.340081e-01 0.030 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.340081e-01 0.030 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.340081e-01 0.030 0 0
Stabilization of p53 R-HSA-69541 9.360377e-01 0.029 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.360377e-01 0.029 0 0
DNA Damage Bypass R-HSA-73893 9.360574e-01 0.029 0 0
Degradation of CDH1 R-HSA-9766229 9.360574e-01 0.029 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.360574e-01 0.029 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.371819e-01 0.028 0 0
Thyroxine biosynthesis R-HSA-209968 9.404442e-01 0.027 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.404442e-01 0.027 0 0
Glucagon-type ligand receptors R-HSA-420092 9.404442e-01 0.027 0 0
Adipogenesis R-HSA-9843745 9.406546e-01 0.027 0 0
Base Excision Repair R-HSA-73884 9.408147e-01 0.026 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.417450e-01 0.026 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.417450e-01 0.026 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.417450e-01 0.026 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.417450e-01 0.026 0 0
Glycogen storage diseases R-HSA-3229121 9.420254e-01 0.026 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.420254e-01 0.026 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.420254e-01 0.026 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.420254e-01 0.026 0 0
Catecholamine biosynthesis R-HSA-209905 9.420254e-01 0.026 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.420254e-01 0.026 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.420254e-01 0.026 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.420254e-01 0.026 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.427233e-01 0.026 0 0
G alpha (q) signalling events R-HSA-416476 9.429921e-01 0.025 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.454199e-01 0.024 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.457203e-01 0.024 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.464580e-01 0.024 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.464580e-01 0.024 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.464580e-01 0.024 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.464580e-01 0.024 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.469767e-01 0.024 0 0
Maturation of spike protein R-HSA-9694548 9.469767e-01 0.024 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.490692e-01 0.023 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.490692e-01 0.023 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.490692e-01 0.023 0 0
Mismatch Repair R-HSA-5358508 9.490692e-01 0.023 0 0
Orc1 removal from chromatin R-HSA-68949 9.505481e-01 0.022 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.505481e-01 0.022 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.517016e-01 0.021 0 0
Selenocysteine synthesis R-HSA-2408557 9.518747e-01 0.021 0 0
Cargo concentration in the ER R-HSA-5694530 9.518901e-01 0.021 0 0
Signaling by GPCR R-HSA-372790 9.529788e-01 0.021 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.546640e-01 0.020 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.546640e-01 0.020 0 0
Pyrimidine biosynthesis R-HSA-500753 9.552575e-01 0.020 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.552575e-01 0.020 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.552575e-01 0.020 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.552575e-01 0.020 0 0
HDL remodeling R-HSA-8964058 9.552575e-01 0.020 0 0
Maturation of nucleoprotein R-HSA-9694631 9.552575e-01 0.020 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.552575e-01 0.020 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.552575e-01 0.020 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.565119e-01 0.019 0 0
Viral mRNA Translation R-HSA-192823 9.578436e-01 0.019 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.578605e-01 0.019 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.584618e-01 0.018 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.584618e-01 0.018 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.601622e-01 0.018 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.606942e-01 0.017 0 0
Creatine metabolism R-HSA-71288 9.606942e-01 0.017 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.606942e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.606942e-01 0.017 0 0
Protein hydroxylation R-HSA-9629569 9.606942e-01 0.017 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.607296e-01 0.017 0 0
Recycling of bile acids and salts R-HSA-159418 9.612152e-01 0.017 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.612152e-01 0.017 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.619635e-01 0.017 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.652010e-01 0.015 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.652010e-01 0.015 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.652010e-01 0.015 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.654705e-01 0.015 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.654705e-01 0.015 0 0
Integrin cell surface interactions R-HSA-216083 9.655203e-01 0.015 0 0
Cellular response to starvation R-HSA-9711097 9.663039e-01 0.015 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.671688e-01 0.014 0 0
Interferon gamma signaling R-HSA-877300 9.681680e-01 0.014 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.687911e-01 0.014 0 0
eNOS activation R-HSA-203615 9.687911e-01 0.014 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.687911e-01 0.014 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.687911e-01 0.014 0 0
Signal amplification R-HSA-392518 9.687911e-01 0.014 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.687911e-01 0.014 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.696667e-01 0.013 0 0
Androgen biosynthesis R-HSA-193048 9.696667e-01 0.013 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.696667e-01 0.013 0 0
Serine metabolism R-HSA-977347 9.696667e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.696667e-01 0.013 0 0
Glucocorticoid biosynthesis R-HSA-194002 9.696667e-01 0.013 0 0
Synthesis of DNA R-HSA-69239 9.699731e-01 0.013 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.702191e-01 0.013 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.720228e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.720228e-01 0.012 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.726627e-01 0.012 0 0
Synthesis of PC R-HSA-1483191 9.729997e-01 0.012 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.733532e-01 0.012 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.733532e-01 0.012 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.733532e-01 0.012 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.733532e-01 0.012 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.749303e-01 0.011 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.749303e-01 0.011 0 0
RNA Polymerase III Transcription R-HSA-74158 9.749303e-01 0.011 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.749303e-01 0.011 0 0
Gluconeogenesis R-HSA-70263 9.755329e-01 0.011 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.755329e-01 0.011 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.757098e-01 0.011 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.765918e-01 0.010 0 0
Carnitine shuttle R-HSA-200425 9.765918e-01 0.010 0 0
Formation of the ureteric bud R-HSA-9830674 9.765918e-01 0.010 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.765918e-01 0.010 0 0
Biosynthesis of maresins R-HSA-9018682 9.765918e-01 0.010 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.768205e-01 0.010 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.775445e-01 0.010 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.778277e-01 0.010 0 0
Collagen degradation R-HSA-1442490 9.778277e-01 0.010 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.794370e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.794370e-01 0.009 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.794370e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.794370e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.794370e-01 0.009 0 0
Ribosome-associated quality control R-HSA-9948299 9.795849e-01 0.009 0 0
HCMV Late Events R-HSA-9610379 9.798150e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.804804e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.818394e-01 0.008 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.819365e-01 0.008 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.819365e-01 0.008 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.819365e-01 0.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.820039e-01 0.008 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.820039e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.823486e-01 0.008 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.841323e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.852060e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.852581e-01 0.006 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.855981e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.860478e-01 0.006 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.860613e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.868390e-01 0.006 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.871228e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9683701 9.871228e-01 0.006 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.877559e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.877559e-01 0.005 0 0
Pyrimidine salvage R-HSA-73614 9.877559e-01 0.005 0 0
G alpha (z) signalling events R-HSA-418597 9.878778e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.880147e-01 0.005 0 0
rRNA processing R-HSA-72312 9.881013e-01 0.005 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.892446e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.894974e-01 0.005 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.897147e-01 0.004 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.897147e-01 0.004 0 0
SARS-CoV Infections R-HSA-9679506 9.900091e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.904433e-01 0.004 0 0
Neurotransmitter clearance R-HSA-112311 9.905523e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.908121e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.911001e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.911001e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.911001e-01 0.004 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.917011e-01 0.004 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.917011e-01 0.004 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.917011e-01 0.004 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.917011e-01 0.004 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.917947e-01 0.004 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.917947e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.917947e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.924524e-01 0.003 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.926743e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.926743e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.926743e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.926743e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.927103e-01 0.003 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.930293e-01 0.003 0 0
Endogenous sterols R-HSA-211976 9.934627e-01 0.003 0 0
Signaling by NOTCH4 R-HSA-9013694 9.934953e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.939816e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.940377e-01 0.003 0 0
Protein ubiquitination R-HSA-8852135 9.940972e-01 0.003 0 0
Heme degradation R-HSA-189483 9.943755e-01 0.002 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.947801e-01 0.002 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.950596e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.950596e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.950596e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.951443e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.953622e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.954901e-01 0.002 0 0
PCP/CE pathway R-HSA-4086400 9.955982e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.955982e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.956605e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.956605e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.956605e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.958607e-01 0.002 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.958607e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.958607e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.960111e-01 0.002 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.960111e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.961572e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.961572e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.961884e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.961884e-01 0.002 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.963100e-01 0.002 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.963100e-01 0.002 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.965173e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.966520e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.966520e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.966520e-01 0.001 0 0
Protein localization R-HSA-9609507 9.968117e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.970593e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.972609e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.973185e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.974171e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.974171e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.974682e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.975279e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.975373e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.977248e-01 0.001 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.977313e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.977313e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.979294e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.980074e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.980074e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.982385e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.983589e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.983589e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.983789e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.984628e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.984628e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.985200e-01 0.001 0 0
Defensins R-HSA-1461973 9.986499e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.986519e-01 0.001 0 0
ER-Phagosome pathway R-HSA-1236974 9.986771e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.988142e-01 0.001 0 0
Methylation R-HSA-156581 9.988142e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.989308e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.989585e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.989715e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.991218e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.991966e-01 0.000 0 0
tRNA processing R-HSA-72306 9.992172e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.993558e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.993572e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993572e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.993572e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.993803e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.993803e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.993857e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.993857e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994287e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.994419e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.994558e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.994586e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.994767e-01 0.000 0 0
Neddylation R-HSA-8951664 9.995601e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.995793e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.995914e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.995992e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.995992e-01 0.000 0 0
Immune System R-HSA-168256 9.996004e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.996313e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.996528e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996721e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.996838e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997192e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.997445e-01 0.000 0 0
Digestion R-HSA-8935690 9.997503e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.997507e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997735e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.997807e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998256e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.998515e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998515e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998515e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998689e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.998696e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998781e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998958e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.998994e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999117e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999117e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999117e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999136e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999168e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999224e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999407e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999475e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999528e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999624e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999644e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999688e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999727e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999738e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999762e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999788e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999832e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999903e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999920e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999933e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999934e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999935e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999956e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999966e-01 0.000 0 0
Translation R-HSA-72766 9.999969e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999977e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999982e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999991e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999991e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999991e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999996e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999996e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 3.330669e-16 15.477 0 0
Cell Cycle R-HSA-1640170 5.839773e-14 13.234 0 0
Cellular response to heat stress R-HSA-3371556 9.259260e-14 13.033 0 0
Cell Cycle, Mitotic R-HSA-69278 1.095790e-13 12.960 0 0
HSF1-dependent transactivation R-HSA-3371571 3.416156e-13 12.466 0 0
Attenuation phase R-HSA-3371568 1.204015e-11 10.919 0 0
Axon guidance R-HSA-422475 1.306499e-11 10.884 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.564837e-11 10.255 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.155765e-10 9.937 0 0
Nervous system development R-HSA-9675108 1.103568e-10 9.957 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.633933e-10 9.787 0 0
Signal Transduction R-HSA-162582 1.645811e-10 9.784 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.015448e-10 9.696 0 0
Aggrephagy R-HSA-9646399 3.828468e-10 9.417 0 0
Meiotic synapsis R-HSA-1221632 5.092361e-10 9.293 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.809554e-10 9.055 0 0
Mitotic Anaphase R-HSA-68882 1.002965e-09 8.999 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.161895e-09 8.935 0 0
Separation of Sister Chromatids R-HSA-2467813 1.715369e-09 8.766 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.825908e-09 8.739 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.258069e-09 8.646 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.352807e-09 8.628 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.532909e-09 8.596 0 0
Mitotic Prometaphase R-HSA-68877 3.576358e-09 8.447 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.608906e-09 8.336 0 0
HCMV Early Events R-HSA-9609690 5.595926e-09 8.252 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.488813e-09 8.261 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.994113e-09 8.222 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.156364e-09 8.211 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.707788e-09 8.173 0 0
Cellular Senescence R-HSA-2559583 9.430869e-09 8.025 0 0
Cell-Cell communication R-HSA-1500931 9.749006e-09 8.011 0 0
HSF1 activation R-HSA-3371511 1.193153e-08 7.923 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.350947e-08 7.869 0 0
Meiosis R-HSA-1500620 1.399632e-08 7.854 0 0
Mitotic Prophase R-HSA-68875 1.709234e-08 7.767 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.787883e-08 7.748 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.912210e-08 7.718 0 0
Kinesins R-HSA-983189 1.912210e-08 7.718 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.871003e-08 7.728 0 0
Apoptotic execution phase R-HSA-75153 2.317061e-08 7.635 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.965536e-08 7.528 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.509702e-08 7.455 0 0
Selective autophagy R-HSA-9663891 3.468051e-08 7.460 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.469695e-08 7.460 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.322700e-08 7.364 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.424582e-08 7.354 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.970968e-08 7.304 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.970968e-08 7.304 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.059576e-08 7.218 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.059576e-08 7.218 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.037439e-08 7.153 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.547697e-08 7.122 0 0
Nucleosome assembly R-HSA-774815 7.547697e-08 7.122 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.560647e-08 7.121 0 0
DNA methylation R-HSA-5334118 7.921730e-08 7.101 0 0
HDACs deacetylate histones R-HSA-3214815 7.852224e-08 7.105 0 0
HCMV Infection R-HSA-9609646 8.919986e-08 7.050 0 0
Signaling by ROBO receptors R-HSA-376176 9.483187e-08 7.023 0 0
Diseases of programmed cell death R-HSA-9645723 1.167005e-07 6.933 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.231092e-07 6.910 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.344777e-07 6.871 0 0
Recycling pathway of L1 R-HSA-437239 1.377720e-07 6.861 0 0
Membrane Trafficking R-HSA-199991 1.615364e-07 6.792 0 0
Defective pyroptosis R-HSA-9710421 1.791387e-07 6.747 0 0
Chromatin organization R-HSA-4839726 1.807916e-07 6.743 0 0
Packaging Of Telomere Ends R-HSA-171306 1.932778e-07 6.714 0 0
Cell junction organization R-HSA-446728 1.873446e-07 6.727 0 0
Autophagy R-HSA-9612973 2.008529e-07 6.697 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.047742e-07 6.689 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.187902e-07 6.660 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.187902e-07 6.660 0 0
Interleukin-12 signaling R-HSA-9020591 2.713468e-07 6.566 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.246798e-07 6.489 0 0
Macroautophagy R-HSA-1632852 3.393244e-07 6.469 0 0
G2/M Transition R-HSA-69275 3.610719e-07 6.442 0 0
Chromatin modifying enzymes R-HSA-3247509 3.730046e-07 6.428 0 0
HATs acetylate histones R-HSA-3214847 4.750882e-07 6.323 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.673448e-07 6.330 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.377813e-07 6.269 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.430902e-07 6.265 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.257563e-07 6.083 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.158822e-07 6.088 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.476585e-07 6.072 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.957711e-07 6.002 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.236876e-06 5.908 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.195823e-06 5.922 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.195823e-06 5.922 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.345219e-06 5.871 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.455513e-06 5.837 0 0
Adherens junctions interactions R-HSA-418990 1.544102e-06 5.811 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.736260e-06 5.760 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.718675e-06 5.765 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.706389e-06 5.768 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.767919e-06 5.753 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.828422e-06 5.738 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.828422e-06 5.738 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.098001e-06 5.678 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.098001e-06 5.678 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.051078e-06 5.688 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.053391e-06 5.688 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.361849e-06 5.627 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.441711e-06 5.612 0 0
Reproduction R-HSA-1474165 2.724423e-06 5.565 0 0
Interleukin-12 family signaling R-HSA-447115 3.021746e-06 5.520 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.287687e-06 5.483 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.122298e-06 5.506 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.108459e-06 5.507 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.290203e-06 5.483 0 0
Deubiquitination R-HSA-5688426 3.539369e-06 5.451 0 0
Peptide chain elongation R-HSA-156902 3.621538e-06 5.441 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.621538e-06 5.441 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.621719e-06 5.441 0 0
RNA Polymerase I Transcription R-HSA-73864 4.366845e-06 5.360 0 0
DNA Double Strand Break Response R-HSA-5693606 5.016006e-06 5.300 0 0
Influenza Infection R-HSA-168255 4.707783e-06 5.327 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.201321e-06 5.284 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.372796e-06 5.270 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.478974e-06 5.261 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.836924e-06 5.234 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.836924e-06 5.234 0 0
Meiotic recombination R-HSA-912446 6.032147e-06 5.220 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.712121e-06 5.173 0 0
PKR-mediated signaling R-HSA-9833482 6.357049e-06 5.197 0 0
Gene Silencing by RNA R-HSA-211000 6.222052e-06 5.206 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.131385e-06 5.147 0 0
Cleavage of the damaged purine R-HSA-110331 7.417458e-06 5.130 0 0
Protein folding R-HSA-391251 8.602997e-06 5.065 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.924939e-06 5.049 0 0
Post NMDA receptor activation events R-HSA-438064 8.924939e-06 5.049 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.133908e-06 5.039 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.220974e-06 5.035 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.586002e-06 5.018 0 0
Depurination R-HSA-73927 9.744946e-06 5.011 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.986776e-06 5.001 0 0
Cell-cell junction organization R-HSA-421270 1.025465e-05 4.989 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.107250e-05 4.956 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.092591e-05 4.962 0 0
Translation initiation complex formation R-HSA-72649 1.191125e-05 4.924 0 0
L1CAM interactions R-HSA-373760 1.209835e-05 4.917 0 0
Gap junction assembly R-HSA-190861 1.317594e-05 4.880 0 0
Gap junction trafficking and regulation R-HSA-157858 1.353248e-05 4.869 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.479405e-05 4.830 0 0
Viral Infection Pathways R-HSA-9824446 1.479755e-05 4.830 0 0
Gap junction trafficking R-HSA-190828 1.509071e-05 4.821 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.740689e-05 4.759 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.656233e-05 4.781 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.648445e-05 4.783 0 0
Metalloprotease DUBs R-HSA-5689901 1.680187e-05 4.775 0 0
Eukaryotic Translation Termination R-HSA-72764 1.643253e-05 4.784 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.734950e-05 4.761 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.746175e-05 4.758 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.748101e-05 4.757 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.940276e-05 4.712 0 0
Cell Cycle Checkpoints R-HSA-69620 1.962803e-05 4.707 0 0
Ribosome-associated quality control R-HSA-9948299 2.244590e-05 4.649 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.246451e-05 4.649 0 0
Protein ubiquitination R-HSA-8852135 2.310806e-05 4.636 0 0
Chromosome Maintenance R-HSA-73886 2.410746e-05 4.618 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.418511e-05 4.616 0 0
Metabolism of RNA R-HSA-8953854 2.457966e-05 4.609 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.756329e-05 4.560 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.092312e-05 4.510 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.364480e-05 4.473 0 0
Death Receptor Signaling R-HSA-73887 3.192509e-05 4.496 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.411712e-05 4.467 0 0
Depyrimidination R-HSA-73928 3.411712e-05 4.467 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.700534e-05 4.432 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.705637e-05 4.431 0 0
Selenocysteine synthesis R-HSA-2408557 4.052410e-05 4.392 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.054751e-05 4.392 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.261015e-05 4.370 0 0
Josephin domain DUBs R-HSA-5689877 4.261015e-05 4.370 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.261015e-05 4.370 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.422117e-05 4.354 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.675499e-05 4.330 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.755424e-05 4.323 0 0
Cellular response to starvation R-HSA-9711097 5.004252e-05 4.301 0 0
RMTs methylate histone arginines R-HSA-3214858 5.375883e-05 4.270 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.064291e-05 4.217 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.186494e-05 4.209 0 0
Amyloid fiber formation R-HSA-977225 6.343481e-05 4.198 0 0
Apoptosis R-HSA-109581 7.705045e-05 4.113 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.273861e-05 4.082 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.904125e-05 4.050 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.037459e-04 3.984 0 0
p75NTR signals via NF-kB R-HSA-193639 1.052115e-04 3.978 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.090268e-04 3.962 0 0
NF-kB is activated and signals survival R-HSA-209560 1.135826e-04 3.945 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.209403e-04 3.917 0 0
Ub-specific processing proteases R-HSA-5689880 1.236802e-04 3.908 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.239844e-04 3.907 0 0
Viral mRNA Translation R-HSA-192823 1.344486e-04 3.871 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.477119e-04 3.831 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.711901e-04 3.767 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.759327e-04 3.755 0 0
TNF signaling R-HSA-75893 1.821054e-04 3.740 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.852796e-04 3.732 0 0
Co-inhibition by PD-1 R-HSA-389948 1.859163e-04 3.731 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.913653e-04 3.718 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.954250e-04 3.709 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.988941e-04 3.701 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.123772e-04 3.673 0 0
Signaling by NOTCH R-HSA-157118 2.230250e-04 3.652 0 0
DNA Replication R-HSA-69306 2.946183e-04 3.531 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.013379e-04 3.521 0 0
ESR-mediated signaling R-HSA-8939211 3.289151e-04 3.483 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.632114e-04 3.440 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.632114e-04 3.440 0 0
Telomere Maintenance R-HSA-157579 3.642631e-04 3.439 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.788200e-04 3.422 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.819619e-04 3.418 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.819619e-04 3.418 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.914949e-04 3.407 0 0
Vesicle-mediated transport R-HSA-5653656 4.153481e-04 3.382 0 0
mTORC1-mediated signalling R-HSA-166208 4.192340e-04 3.378 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.226204e-04 3.374 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.241571e-04 3.372 0 0
HCMV Late Events R-HSA-9610379 4.337196e-04 3.363 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.375262e-04 3.359 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.403989e-04 3.356 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.406213e-04 3.356 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.639676e-04 3.334 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.664879e-04 3.331 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.783480e-04 3.320 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.809354e-04 3.318 0 0
Homology Directed Repair R-HSA-5693538 5.006291e-04 3.300 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.424755e-04 3.266 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.487103e-04 3.261 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.264109e-04 3.279 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.126163e-04 3.290 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.424755e-04 3.266 0 0
Cilium Assembly R-HSA-5617833 5.815003e-04 3.235 0 0
Hedgehog 'off' state R-HSA-5610787 5.264109e-04 3.279 0 0
Programmed Cell Death R-HSA-5357801 5.969364e-04 3.224 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.048990e-04 3.218 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.235511e-04 3.205 0 0
Late endosomal microautophagy R-HSA-9615710 6.323216e-04 3.199 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.585777e-04 3.181 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.585777e-04 3.181 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.585777e-04 3.181 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.929802e-04 3.159 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.161599e-04 3.145 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.161599e-04 3.145 0 0
Negative regulation of MET activity R-HSA-6807004 7.571729e-04 3.121 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.581400e-04 3.120 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.927257e-04 3.101 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.371117e-04 3.077 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.588932e-04 3.066 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.588932e-04 3.066 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.075563e-04 3.042 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.376716e-04 3.028 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.376716e-04 3.028 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.443163e-04 3.025 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.443163e-04 3.025 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.547337e-04 3.020 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.091911e-03 2.962 0 0
mRNA Splicing R-HSA-72172 1.028456e-03 2.988 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.695689e-04 3.013 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.026290e-03 2.989 0 0
MAP kinase activation R-HSA-450294 1.150564e-03 2.939 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.124207e-03 2.949 0 0
MTOR signalling R-HSA-165159 1.201528e-03 2.920 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.209815e-03 2.917 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.251927e-03 2.902 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.283763e-03 2.892 0 0
G2/M Checkpoints R-HSA-69481 1.392602e-03 2.856 0 0
Interferon Signaling R-HSA-913531 1.431461e-03 2.844 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.480029e-03 2.830 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.531494e-03 2.815 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.531494e-03 2.815 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.537654e-03 2.813 0 0
Base Excision Repair R-HSA-73884 1.570702e-03 2.804 0 0
Regulation of CDH1 Function R-HSA-9764561 1.688914e-03 2.772 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.776476e-03 2.750 0 0
MHC class II antigen presentation R-HSA-2132295 1.776476e-03 2.750 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.808031e-03 2.743 0 0
Striated Muscle Contraction R-HSA-390522 1.808031e-03 2.743 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.854681e-03 2.732 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.013208e-03 2.696 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.072234e-03 2.684 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.177803e-03 2.662 0 0
Signaling by WNT R-HSA-195721 2.242001e-03 2.649 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.330887e-03 2.632 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.403150e-03 2.619 0 0
Signaling by Interleukins R-HSA-449147 2.464262e-03 2.608 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.499676e-03 2.602 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.499676e-03 2.602 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.590217e-03 2.587 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.939618e-03 2.532 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.719611e-03 2.565 0 0
Nephrin family interactions R-HSA-373753 2.991931e-03 2.524 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.304644e-03 2.481 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.119734e-03 2.506 0 0
UCH proteinases R-HSA-5689603 3.320707e-03 2.479 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.452800e-03 2.462 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.485105e-03 2.458 0 0
DNA Damage Bypass R-HSA-73893 3.656201e-03 2.437 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.696752e-03 2.432 0 0
Signaling by EGFR R-HSA-177929 3.772339e-03 2.423 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.776361e-03 2.423 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.776361e-03 2.423 0 0
Interleukin-17 signaling R-HSA-448424 3.792907e-03 2.421 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.792907e-03 2.421 0 0
Semaphorin interactions R-HSA-373755 3.812375e-03 2.419 0 0
SARS-CoV Infections R-HSA-9679506 3.946658e-03 2.404 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.013462e-03 2.396 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.046503e-03 2.393 0 0
rRNA processing R-HSA-72312 4.070281e-03 2.390 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.264302e-03 2.370 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.264302e-03 2.370 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.541031e-03 2.343 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.541031e-03 2.343 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.541031e-03 2.343 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.577800e-03 2.339 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.577800e-03 2.339 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.577800e-03 2.339 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.710904e-03 2.327 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.736217e-03 2.325 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.737782e-03 2.324 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.796797e-03 2.319 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.796797e-03 2.319 0 0
Adaptive Immune System R-HSA-1280218 4.973284e-03 2.303 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.105491e-03 2.292 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.105491e-03 2.292 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.374442e-03 2.270 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.469193e-03 2.262 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.492025e-03 2.260 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.528767e-03 2.257 0 0
mRNA 3'-end processing R-HSA-72187 5.535312e-03 2.257 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.535312e-03 2.257 0 0
snRNP Assembly R-HSA-191859 5.560856e-03 2.255 0 0
Metabolism of non-coding RNA R-HSA-194441 5.560856e-03 2.255 0 0
HIV Life Cycle R-HSA-162587 5.917932e-03 2.228 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.091179e-03 2.215 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.205564e-03 2.207 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.205564e-03 2.207 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.210872e-03 2.207 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.210872e-03 2.207 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.210872e-03 2.207 0 0
Signaling by RAS mutants R-HSA-6802949 6.210872e-03 2.207 0 0
Signaling by ERBB2 R-HSA-1227986 6.289398e-03 2.201 0 0
Nuclear import of Rev protein R-HSA-180746 6.475128e-03 2.189 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.475128e-03 2.189 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.442571e-03 2.074 0 0
Regulation of signaling by CBL R-HSA-912631 8.614476e-03 2.065 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.614476e-03 2.065 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.614476e-03 2.065 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.594208e-03 2.066 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.189316e-03 2.087 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.589650e-03 2.120 0 0
Centrosome maturation R-HSA-380287 6.699113e-03 2.174 0 0
MAP2K and MAPK activation R-HSA-5674135 7.978588e-03 2.098 0 0
Signaling by VEGF R-HSA-194138 8.833892e-03 2.054 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.594208e-03 2.066 0 0
Neurodegenerative Diseases R-HSA-8863678 8.594208e-03 2.066 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.939401e-03 2.100 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.777343e-03 2.169 0 0
Intraflagellar transport R-HSA-5620924 8.134172e-03 2.090 0 0
Developmental Biology R-HSA-1266738 7.383101e-03 2.132 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.168563e-03 2.145 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.699113e-03 2.174 0 0
FLT3 Signaling R-HSA-9607240 6.908163e-03 2.161 0 0
Maturation of protein E R-HSA-9683683 7.445358e-03 2.128 0 0
Maturation of protein E R-HSA-9694493 7.445358e-03 2.128 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.846569e-03 2.053 0 0
Neutrophil degranulation R-HSA-6798695 8.861932e-03 2.052 0 0
NRAGE signals death through JNK R-HSA-193648 9.161551e-03 2.038 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.305464e-03 2.031 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.510881e-03 2.022 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.551494e-03 2.020 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.551494e-03 2.020 0 0
EGFR downregulation R-HSA-182971 9.661664e-03 2.015 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.661664e-03 2.015 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.661664e-03 2.015 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.661664e-03 2.015 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.999654e-03 2.000 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.016001e-02 1.993 0 0
DCC mediated attractive signaling R-HSA-418885 1.016001e-02 1.993 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.016001e-02 1.993 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.016001e-02 1.993 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.025703e-02 1.989 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.030985e-02 1.987 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.030985e-02 1.987 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.050211e-02 1.979 0 0
CREB phosphorylation R-HSA-199920 1.108428e-02 1.955 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.108428e-02 1.955 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.113214e-02 1.953 0 0
Signaling by ALK in cancer R-HSA-9700206 1.113214e-02 1.953 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.133631e-02 1.946 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.185732e-02 1.926 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.205162e-02 1.919 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.205162e-02 1.919 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.209538e-02 1.917 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.233454e-02 1.909 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.233454e-02 1.909 0 0
Negative regulation of FLT3 R-HSA-9706369 1.278936e-02 1.893 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.287836e-02 1.890 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.287836e-02 1.890 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.290262e-02 1.889 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.319433e-02 1.880 0 0
DNA Repair R-HSA-73894 1.372331e-02 1.863 0 0
Host Interactions of HIV factors R-HSA-162909 1.399120e-02 1.854 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.448387e-02 1.839 0 0
Signaling by Hedgehog R-HSA-5358351 1.458970e-02 1.836 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.512267e-02 1.820 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.528289e-02 1.816 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.534406e-02 1.814 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.538102e-02 1.813 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.550030e-02 1.810 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.550030e-02 1.810 0 0
Assembly Of The HIV Virion R-HSA-175474 1.550030e-02 1.810 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.570600e-02 1.804 0 0
Regulation of PTEN localization R-HSA-8948747 1.570600e-02 1.804 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.572030e-02 1.804 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.572030e-02 1.804 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.572030e-02 1.804 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.572030e-02 1.804 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.572030e-02 1.804 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.604937e-02 1.795 0 0
Selenoamino acid metabolism R-HSA-2408522 1.651927e-02 1.782 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.660035e-02 1.780 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.765903e-02 1.753 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.848048e-02 1.733 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.854902e-02 1.732 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.900460e-02 1.721 0 0
Signaling by Hippo R-HSA-2028269 1.941025e-02 1.712 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.970289e-02 1.705 0 0
Signaling by PTK6 R-HSA-8848021 1.970289e-02 1.705 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.976796e-02 1.704 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.031380e-02 1.692 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.031834e-02 1.692 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.104699e-02 1.677 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.138373e-02 1.670 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.138373e-02 1.670 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.138373e-02 1.670 0 0
Regulation of TP53 Activity R-HSA-5633007 2.169874e-02 1.664 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.179182e-02 1.662 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.257137e-02 1.646 0 0
FLT3 signaling in disease R-HSA-9682385 2.300214e-02 1.638 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.346357e-02 1.630 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.346357e-02 1.630 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.346357e-02 1.630 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.610317e-02 1.583 0 0
Budding and maturation of HIV virion R-HSA-162588 2.629734e-02 1.580 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.629734e-02 1.580 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.817118e-02 1.550 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.817118e-02 1.550 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.844849e-02 1.546 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.844849e-02 1.546 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.844849e-02 1.546 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.882566e-02 1.540 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.325763e-02 1.478 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.325763e-02 1.478 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.950783e-02 1.530 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.610297e-02 1.442 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.584191e-02 1.446 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.584191e-02 1.446 0 0
Translesion synthesis by POLI R-HSA-5656121 4.299585e-02 1.367 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.318755e-02 1.479 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.440301e-02 1.463 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.947350e-02 1.404 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.947350e-02 1.404 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.419311e-02 1.466 0 0
Dual Incision in GG-NER R-HSA-5696400 4.355782e-02 1.361 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.169035e-02 1.499 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.523494e-02 1.453 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.145746e-02 1.382 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.890036e-02 1.410 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.355782e-02 1.361 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.715576e-02 1.430 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.145746e-02 1.382 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.950783e-02 1.530 0 0
Translesion synthesis by REV1 R-HSA-110312 3.584191e-02 1.446 0 0
G alpha (12/13) signalling events R-HSA-416482 3.738232e-02 1.427 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.369798e-02 1.360 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.325763e-02 1.478 0 0
HIV Infection R-HSA-162906 3.275215e-02 1.485 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.946144e-02 1.531 0 0
EPH-Ephrin signaling R-HSA-2682334 3.650979e-02 1.438 0 0
Signaling by NOTCH1 R-HSA-1980143 3.174844e-02 1.498 0 0
Interleukin-1 signaling R-HSA-9020702 4.114870e-02 1.386 0 0
Mitophagy R-HSA-5205647 4.355782e-02 1.361 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.745179e-02 1.427 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.947355e-02 1.531 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.419311e-02 1.466 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.523494e-02 1.453 0 0
Platelet degranulation R-HSA-114608 3.231545e-02 1.491 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.610297e-02 1.442 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.440301e-02 1.463 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.947350e-02 1.404 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.429591e-02 1.465 0 0
Signaling by Leptin R-HSA-2586552 3.610297e-02 1.442 0 0
Muscle contraction R-HSA-397014 3.745179e-02 1.427 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.097293e-02 1.509 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.145746e-02 1.382 0 0
Interleukin-1 family signaling R-HSA-446652 3.689465e-02 1.433 0 0
Smooth Muscle Contraction R-HSA-445355 3.313218e-02 1.480 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.222133e-02 1.492 0 0
Signaling by MET R-HSA-6806834 4.369798e-02 1.360 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.715576e-02 1.430 0 0
Pexophagy R-HSA-9664873 3.610297e-02 1.442 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.500850e-02 1.347 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.520216e-02 1.345 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.520216e-02 1.345 0 0
TCR signaling R-HSA-202403 4.559607e-02 1.341 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.608282e-02 1.336 0 0
Circadian clock R-HSA-9909396 4.627441e-02 1.335 1 0
Toll-like Receptor Cascades R-HSA-168898 4.698884e-02 1.328 0 0
S Phase R-HSA-69242 4.772348e-02 1.321 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.881714e-02 1.311 0 0
MAPK family signaling cascades R-HSA-5683057 4.945824e-02 1.306 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.094815e-02 1.293 0 0
Translesion synthesis by POLK R-HSA-5655862 5.094815e-02 1.293 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.094815e-02 1.293 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.101833e-02 1.292 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.101833e-02 1.292 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.101833e-02 1.292 0 0
Notch-HLH transcription pathway R-HSA-350054 5.210431e-02 1.283 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.210431e-02 1.283 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.475673e-02 1.262 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.562086e-02 1.255 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.562086e-02 1.255 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.562086e-02 1.255 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.562086e-02 1.255 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.562086e-02 1.255 0 0
TBC/RABGAPs R-HSA-8854214 5.633321e-02 1.249 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.751087e-02 1.240 0 0
Interleukin-37 signaling R-HSA-9008059 5.751087e-02 1.240 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.850610e-02 1.233 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.961414e-02 1.225 0 0
Syndecan interactions R-HSA-3000170 5.961414e-02 1.225 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 5.970407e-02 1.224 0 0
Glycogen storage diseases R-HSA-3229121 5.970407e-02 1.224 0 0
Degradation of DVL R-HSA-4641258 6.052866e-02 1.218 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.052866e-02 1.218 0 0
Immune System R-HSA-168256 6.190930e-02 1.208 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.196983e-02 1.208 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.199800e-02 1.208 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.199800e-02 1.208 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.199800e-02 1.208 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.199800e-02 1.208 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.199800e-02 1.208 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.449155e-02 1.190 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.449155e-02 1.190 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.684512e-02 1.175 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.684512e-02 1.175 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.684512e-02 1.175 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.773498e-02 1.169 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.789498e-02 1.168 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.789498e-02 1.168 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.926171e-02 1.160 0 0
Infectious disease R-HSA-5663205 6.982755e-02 1.156 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.022436e-02 1.154 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.022436e-02 1.154 0 0
PTEN Regulation R-HSA-6807070 7.102955e-02 1.149 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.196330e-02 1.143 0 0
tRNA processing in the nucleus R-HSA-6784531 7.257083e-02 1.139 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.374637e-02 1.132 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.386379e-02 1.132 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.386379e-02 1.132 0 0
Interleukin-7 signaling R-HSA-1266695 7.646618e-02 1.117 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.646618e-02 1.117 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.935644e-02 1.100 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.935644e-02 1.100 0 0
Translesion Synthesis by POLH R-HSA-110320 7.961228e-02 1.099 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.961228e-02 1.099 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.990406e-02 1.097 0 0
Signaling by NOTCH3 R-HSA-9012852 7.990406e-02 1.097 0 0
Integrin signaling R-HSA-354192 7.992657e-02 1.097 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.992657e-02 1.097 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.992657e-02 1.097 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.992657e-02 1.097 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.097070e-02 1.092 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.114637e-02 1.091 0 0
Diseases of Immune System R-HSA-5260271 8.114637e-02 1.091 0 0
MET interacts with TNS proteins R-HSA-8875513 8.179942e-02 1.087 0 0
Signaling by TGFB family members R-HSA-9006936 8.577222e-02 1.067 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.580322e-02 1.066 1 1
Suppression of phagosomal maturation R-HSA-9637687 8.580322e-02 1.066 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.636915e-02 1.064 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.636915e-02 1.064 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.636915e-02 1.064 0 0
Type I hemidesmosome assembly R-HSA-446107 8.741976e-02 1.058 0 0
Formation of annular gap junctions R-HSA-196025 8.741976e-02 1.058 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.753455e-02 1.058 0 0
Hemostasis R-HSA-109582 8.981424e-02 1.047 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.007698e-02 1.045 0 0
Glycogen synthesis R-HSA-3322077 9.074059e-02 1.042 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.074059e-02 1.042 0 0
Formation of definitive endoderm R-HSA-9823730 9.074059e-02 1.042 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.074059e-02 1.042 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.294043e-02 1.032 0 0
Signaling by NOTCH4 R-HSA-9013694 9.354431e-02 1.029 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.693918e-02 1.014 0 0
RAF activation R-HSA-5673000 9.731731e-02 1.012 0 0
Signaling by NOTCH2 R-HSA-1980145 9.731731e-02 1.012 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.731731e-02 1.012 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.731731e-02 1.012 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.949720e-02 1.002 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.026255e-01 0.989 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.026255e-01 0.989 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.026255e-01 0.989 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.031308e-01 0.987 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.048813e-01 0.979 0 0
Ca-dependent events R-HSA-111996 1.054435e-01 0.977 0 0
Lipophagy R-HSA-9613354 1.061909e-01 0.974 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.061909e-01 0.974 0 0
Gap junction degradation R-HSA-190873 1.061909e-01 0.974 0 0
ALK mutants bind TKIs R-HSA-9700645 1.061909e-01 0.974 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.061909e-01 0.974 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.061909e-01 0.974 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.062585e-01 0.974 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.067337e-01 0.972 0 0
Regulation of Apoptosis R-HSA-169911 1.067337e-01 0.972 0 0
Oncogene Induced Senescence R-HSA-2559585 1.067337e-01 0.972 0 0
Regulation of gap junction activity R-HSA-191650 1.109254e-01 0.955 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.109254e-01 0.955 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.109254e-01 0.955 0 0
MTF1 activates gene expression R-HSA-5660489 1.109254e-01 0.955 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.109254e-01 0.955 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.152406e-01 0.938 0 0
Calmodulin induced events R-HSA-111933 1.166195e-01 0.933 0 0
CaM pathway R-HSA-111997 1.166195e-01 0.933 0 0
DARPP-32 events R-HSA-180024 1.173500e-01 0.931 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.173500e-01 0.931 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.196376e-01 0.922 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.196376e-01 0.922 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.231098e-01 0.910 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.231098e-01 0.910 0 0
Regulation of BACH1 activity R-HSA-9708530 1.231098e-01 0.910 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.232797e-01 0.909 0 0
Netrin-1 signaling R-HSA-373752 1.236412e-01 0.908 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.236412e-01 0.908 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.278905e-01 0.893 0 0
Pyruvate metabolism R-HSA-70268 1.281069e-01 0.892 0 0
FGFR2 alternative splicing R-HSA-6803529 1.285545e-01 0.891 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.315611e-01 0.881 0 0
Heme signaling R-HSA-9707616 1.315611e-01 0.881 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.335681e-01 0.874 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.335681e-01 0.874 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.720450e-01 0.764 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.720450e-01 0.764 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.720450e-01 0.764 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.466335e-01 0.608 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.466335e-01 0.608 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.466335e-01 0.608 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.466335e-01 0.608 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.466335e-01 0.608 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.466335e-01 0.608 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.466335e-01 0.608 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.466335e-01 0.608 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.466335e-01 0.608 0 0
IRS activation R-HSA-74713 1.422563e-01 0.847 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 1.422563e-01 0.847 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.090968e-01 0.680 0 0
STAT5 Activation R-HSA-9645135 2.090968e-01 0.680 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.090968e-01 0.680 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.436164e-01 0.613 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.436164e-01 0.613 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.436164e-01 0.613 0 0
SOS-mediated signalling R-HSA-112412 2.436164e-01 0.613 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.936761e-01 0.713 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.568444e-01 0.805 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.568444e-01 0.805 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.177950e-01 0.662 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 2.177950e-01 0.662 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.571332e-01 0.804 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.128168e-01 0.672 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.675941e-01 0.573 0 0
Degradation of CDH1 R-HSA-9766229 1.756492e-01 0.755 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.553446e-01 0.593 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.108181e-01 0.676 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.231088e-01 0.651 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.519349e-01 0.599 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.627070e-01 0.581 0 0
Nucleotide Excision Repair R-HSA-5696398 1.483749e-01 0.829 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.553446e-01 0.593 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.076480e-01 0.683 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.527782e-01 0.597 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.936761e-01 0.713 0 0
TGFBR3 expression R-HSA-9839394 1.723167e-01 0.764 0 0
Interleukin-2 signaling R-HSA-9020558 1.477966e-01 0.830 0 0
GAB1 signalosome R-HSA-180292 1.748649e-01 0.757 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.379845e-01 0.623 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.477966e-01 0.830 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.880375e-01 0.726 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.935492e-01 0.713 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.850407e-01 0.733 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.395672e-01 0.855 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.936761e-01 0.713 0 0
Orc1 removal from chromatin R-HSA-68949 2.108181e-01 0.676 0 0
Developmental Cell Lineages R-HSA-9734767 2.254832e-01 0.647 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.867092e-01 0.729 0 0
Rap1 signalling R-HSA-392517 1.935492e-01 0.713 0 0
Neurexins and neuroligins R-HSA-6794361 2.108181e-01 0.676 0 0
Opioid Signalling R-HSA-111885 2.047802e-01 0.689 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.720450e-01 0.764 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.751590e-01 0.757 0 0
Platelet sensitization by LDL R-HSA-432142 1.748649e-01 0.757 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.424848e-01 0.615 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.726358e-01 0.763 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.091332e-01 0.680 0 0
PLC beta mediated events R-HSA-112043 2.096015e-01 0.679 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.670220e-01 0.777 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.492410e-01 0.603 0 0
Synthesis of DNA R-HSA-69239 2.400628e-01 0.620 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.936761e-01 0.713 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.751590e-01 0.757 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.538549e-01 0.813 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.537848e-01 0.813 0 0
Rab regulation of trafficking R-HSA-9007101 1.823681e-01 0.739 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.493877e-01 0.826 0 0
Myogenesis R-HSA-525793 1.880375e-01 0.726 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.489731e-01 0.827 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.108932e-01 0.676 0 0
DAG and IP3 signaling R-HSA-1489509 2.379845e-01 0.623 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.379845e-01 0.623 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.363658e-01 0.865 0 0
Signal transduction by L1 R-HSA-445144 2.128168e-01 0.672 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.231088e-01 0.651 0 0
Translation R-HSA-72766 1.379653e-01 0.860 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.590170e-01 0.799 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.720450e-01 0.764 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.466335e-01 0.608 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.466335e-01 0.608 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.466335e-01 0.608 0 0
Bicarbonate transporters R-HSA-425381 1.477966e-01 0.830 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.436164e-01 0.613 0 0
Regulation of KIT signaling R-HSA-1433559 2.424848e-01 0.615 0 0
Physiological factors R-HSA-5578768 2.424848e-01 0.615 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.675941e-01 0.573 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.401322e-01 0.853 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.239375e-01 0.650 0 0
Degradation of AXIN R-HSA-4641257 2.390713e-01 0.621 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.390713e-01 0.621 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.379845e-01 0.623 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.474432e-01 0.831 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.631012e-01 0.580 0 0
Cellular response to chemical stress R-HSA-9711123 1.518830e-01 0.818 0 0
Co-stimulation by CD28 R-HSA-389356 1.645488e-01 0.784 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.377532e-01 0.861 0 0
PECAM1 interactions R-HSA-210990 1.477966e-01 0.830 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.751590e-01 0.757 0 0
Nef and signal transduction R-HSA-164944 2.090968e-01 0.680 0 0
CHL1 interactions R-HSA-447041 2.436164e-01 0.613 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.806440e-01 0.743 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.946913e-01 0.711 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.946913e-01 0.711 0 0
Glycogen metabolism R-HSA-8982491 1.606067e-01 0.794 0 0
Signaling by FGFR2 R-HSA-5654738 1.347172e-01 0.871 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.379845e-01 0.623 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.379845e-01 0.623 0 0
Integration of provirus R-HSA-162592 1.702878e-01 0.769 0 0
Signaling by FGFR4 R-HSA-5654743 2.108932e-01 0.676 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.466335e-01 0.608 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.751590e-01 0.757 0 0
OAS antiviral response R-HSA-8983711 1.936761e-01 0.713 0 0
Protein methylation R-HSA-8876725 2.675941e-01 0.573 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.675941e-01 0.573 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.606067e-01 0.794 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.379845e-01 0.623 0 0
Downstream TCR signaling R-HSA-202424 1.500762e-01 0.824 0 0
Signaling by FGFR3 R-HSA-5654741 2.379845e-01 0.623 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.182612e-01 0.661 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.416776e-01 0.849 0 0
The NLRP3 inflammasome R-HSA-844456 1.935492e-01 0.713 0 0
Signaling by ERBB4 R-HSA-1236394 2.513205e-01 0.600 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.401766e-01 0.619 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.531166e-01 0.815 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.751590e-01 0.757 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.655992e-01 0.781 0 0
Stimuli-sensing channels R-HSA-2672351 2.492410e-01 0.603 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.379845e-01 0.623 0 0
Glycolysis R-HSA-70171 2.551791e-01 0.593 0 0
Specification of primordial germ cells R-HSA-9827857 1.568444e-01 0.805 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.436164e-01 0.613 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.395672e-01 0.855 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.675941e-01 0.573 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.450459e-01 0.611 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.751590e-01 0.757 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.325866e-01 0.633 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.566278e-01 0.805 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.676829e-01 0.572 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.701926e-01 0.568 0 0
Stabilization of p53 R-HSA-69541 2.701926e-01 0.568 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.701926e-01 0.568 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.701926e-01 0.568 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.704546e-01 0.568 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.733125e-01 0.563 0 0
RSK activation R-HSA-444257 2.783381e-01 0.555 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.783381e-01 0.555 0 0
Interleukin-9 signaling R-HSA-8985947 2.783381e-01 0.555 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.783381e-01 0.555 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.783381e-01 0.555 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.783381e-01 0.555 0 0
G-protein mediated events R-HSA-112040 2.810375e-01 0.551 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.861121e-01 0.543 0 0
Inositol phosphate metabolism R-HSA-1483249 2.871904e-01 0.542 0 0
Dual incision in TC-NER R-HSA-6782135 2.880055e-01 0.541 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.897762e-01 0.538 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.897762e-01 0.538 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.929809e-01 0.533 0 0
Phosphorylation of the APC/C R-HSA-176412 2.929809e-01 0.533 0 0
Regulated Necrosis R-HSA-5218859 2.935746e-01 0.532 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.935746e-01 0.532 0 0
Growth hormone receptor signaling R-HSA-982772 2.941124e-01 0.531 0 0
Interleukin-20 family signaling R-HSA-8854691 2.941124e-01 0.531 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.015387e-01 0.521 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.022252e-01 0.520 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.022252e-01 0.520 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.022252e-01 0.520 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.090988e-01 0.510 0 0
Sensory processing of sound R-HSA-9659379 3.097491e-01 0.509 0 0
ARMS-mediated activation R-HSA-170984 3.129456e-01 0.505 0 0
WNT mediated activation of DVL R-HSA-201688 3.129456e-01 0.505 0 0
Interleukin-21 signaling R-HSA-9020958 3.129456e-01 0.505 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.129456e-01 0.505 0 0
Calcineurin activates NFAT R-HSA-2025928 3.129456e-01 0.505 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.129456e-01 0.505 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.129456e-01 0.505 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.129456e-01 0.505 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.129456e-01 0.505 0 0
Interleukin-1 processing R-HSA-448706 3.129456e-01 0.505 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.129456e-01 0.505 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.129456e-01 0.505 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.145065e-01 0.502 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.145065e-01 0.502 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.145065e-01 0.502 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.145065e-01 0.502 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.145065e-01 0.502 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.145065e-01 0.502 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.145065e-01 0.502 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.151035e-01 0.502 0 0
Deadenylation of mRNA R-HSA-429947 3.151035e-01 0.502 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.184982e-01 0.497 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.184982e-01 0.497 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.185132e-01 0.497 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.185132e-01 0.497 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.185132e-01 0.497 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.185132e-01 0.497 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.185132e-01 0.497 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.190482e-01 0.496 0 0
ER-Phagosome pathway R-HSA-1236974 3.238099e-01 0.490 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.247357e-01 0.488 0 0
Hedgehog 'on' state R-HSA-5632684 3.319525e-01 0.479 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.348976e-01 0.475 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.348976e-01 0.475 0 0
Signaling by FGFR R-HSA-190236 3.362129e-01 0.473 0 0
HDMs demethylate histones R-HSA-3214842 3.362146e-01 0.473 0 0
Interferon alpha/beta signaling R-HSA-909733 3.368830e-01 0.473 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.440697e-01 0.463 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.440697e-01 0.463 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.440697e-01 0.463 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.440697e-01 0.463 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.440697e-01 0.463 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.449472e-01 0.462 0 0
Binding and entry of HIV virion R-HSA-173107 3.471778e-01 0.459 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.471778e-01 0.459 0 0
2-LTR circle formation R-HSA-164843 3.471778e-01 0.459 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.471778e-01 0.459 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.471778e-01 0.459 0 0
PI3K/AKT activation R-HSA-198203 3.471778e-01 0.459 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.471778e-01 0.459 0 0
Signal attenuation R-HSA-74749 3.471778e-01 0.459 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.471778e-01 0.459 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.513907e-01 0.454 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.573777e-01 0.447 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.573777e-01 0.447 0 0
ABC-family proteins mediated transport R-HSA-382556 3.584137e-01 0.446 0 0
IRE1alpha activates chaperones R-HSA-381070 3.586460e-01 0.445 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.679453e-01 0.434 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.695396e-01 0.432 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.695396e-01 0.432 0 0
PKA activation R-HSA-163615 3.695396e-01 0.432 0 0
PKA activation in glucagon signalling R-HSA-164378 3.695396e-01 0.432 0 0
Ephrin signaling R-HSA-3928664 3.695396e-01 0.432 0 0
Mismatch Repair R-HSA-5358508 3.695396e-01 0.432 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.695396e-01 0.432 0 0
MET activates PTPN11 R-HSA-8865999 3.762683e-01 0.425 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.762683e-01 0.425 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 3.762683e-01 0.425 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.762683e-01 0.425 0 0
FasL/ CD95L signaling R-HSA-75157 3.762683e-01 0.425 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.762683e-01 0.425 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.762683e-01 0.425 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.785289e-01 0.422 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.785289e-01 0.422 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.785289e-01 0.422 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.785289e-01 0.422 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.785289e-01 0.422 0 0
Signaling by APC mutants R-HSA-4839744 3.808217e-01 0.419 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.808217e-01 0.419 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.808217e-01 0.419 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.808217e-01 0.419 0 0
Formation of the posterior neural plate R-HSA-9832991 3.808217e-01 0.419 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.808217e-01 0.419 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.808217e-01 0.419 0 0
RET signaling R-HSA-8853659 3.826781e-01 0.417 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.948228e-01 0.404 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.948228e-01 0.404 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.957987e-01 0.403 0 0
Inflammasomes R-HSA-622312 3.996080e-01 0.398 0 0
Signaling by FGFR1 R-HSA-5654736 4.003131e-01 0.398 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.011156e-01 0.397 0 0
Signaling by TGFBR3 R-HSA-9839373 4.011156e-01 0.397 0 0
Ion channel transport R-HSA-983712 4.081828e-01 0.389 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.082667e-01 0.389 0 0
Transmission across Chemical Synapses R-HSA-112315 4.103132e-01 0.387 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.137055e-01 0.383 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.137055e-01 0.383 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.137055e-01 0.383 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.137055e-01 0.383 0 0
Signaling by AXIN mutants R-HSA-4839735 4.137055e-01 0.383 0 0
Activation of RAC1 R-HSA-428540 4.137055e-01 0.383 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.137055e-01 0.383 0 0
Gene expression (Transcription) R-HSA-74160 4.142632e-01 0.383 0 0
RSV-host interactions R-HSA-9833110 4.146840e-01 0.382 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.154949e-01 0.381 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.194942e-01 0.377 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.198298e-01 0.377 0 0
Signaling by NODAL R-HSA-1181150 4.198298e-01 0.377 0 0
Protein hydroxylation R-HSA-9629569 4.198298e-01 0.377 0 0
Potential therapeutics for SARS R-HSA-9679191 4.198682e-01 0.377 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.205591e-01 0.376 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.205591e-01 0.376 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.230564e-01 0.374 0 0
PCP/CE pathway R-HSA-4086400 4.239268e-01 0.373 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.324688e-01 0.364 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.324688e-01 0.364 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.324688e-01 0.364 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.324688e-01 0.364 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.324688e-01 0.364 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.324688e-01 0.364 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.324688e-01 0.364 0 0
Dopamine receptors R-HSA-390651 4.324688e-01 0.364 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.324688e-01 0.364 0 0
RAS processing R-HSA-9648002 4.377709e-01 0.359 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.412784e-01 0.355 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.413303e-01 0.355 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.413303e-01 0.355 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.413303e-01 0.355 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.444811e-01 0.352 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.444811e-01 0.352 0 0
Basigin interactions R-HSA-210991 4.444811e-01 0.352 0 0
ERK/MAPK targets R-HSA-198753 4.444811e-01 0.352 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.456931e-01 0.351 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.456931e-01 0.351 0 0
Repression of WNT target genes R-HSA-4641265 4.456931e-01 0.351 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.456931e-01 0.351 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.456931e-01 0.351 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.456931e-01 0.351 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.456931e-01 0.351 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.456931e-01 0.351 0 0
Interleukin-15 signaling R-HSA-8983432 4.456931e-01 0.351 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.456931e-01 0.351 0 0
Regulation of IFNG signaling R-HSA-877312 4.456931e-01 0.351 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.505886e-01 0.346 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.505886e-01 0.346 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.505886e-01 0.346 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.582464e-01 0.339 0 0
Trafficking of AMPA receptors R-HSA-399719 4.618741e-01 0.335 0 0
Glucose metabolism R-HSA-70326 4.659178e-01 0.332 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.687068e-01 0.329 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.687068e-01 0.329 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.704405e-01 0.327 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.766793e-01 0.322 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.766793e-01 0.322 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.766793e-01 0.322 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.766793e-01 0.322 0 0
Interleukin-6 signaling R-HSA-1059683 4.766793e-01 0.322 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.766793e-01 0.322 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.830725e-01 0.316 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.836085e-01 0.316 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.836085e-01 0.316 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.836085e-01 0.316 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.836085e-01 0.316 0 0
PTK6 Down-Regulation R-HSA-8849472 4.836085e-01 0.316 0 0
Activation of C3 and C5 R-HSA-174577 4.836085e-01 0.316 0 0
Reelin signalling pathway R-HSA-8866376 4.836085e-01 0.316 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.836085e-01 0.316 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.836085e-01 0.316 0 0
Inositol transporters R-HSA-429593 4.836085e-01 0.316 0 0
Co-inhibition by BTLA R-HSA-9927353 4.836085e-01 0.316 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.836085e-01 0.316 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.836085e-01 0.316 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.836085e-01 0.316 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.883396e-01 0.311 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.883843e-01 0.311 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.905324e-01 0.309 0 0
Translation of Structural Proteins R-HSA-9683701 4.916666e-01 0.308 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.924465e-01 0.308 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.924465e-01 0.308 0 0
Disease R-HSA-1643685 4.943230e-01 0.306 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.949607e-01 0.305 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 4.950139e-01 0.305 0 0
PI Metabolism R-HSA-1483255 5.000195e-01 0.301 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.021102e-01 0.299 0 0
Nuclear RNA decay R-HSA-9930044 5.021102e-01 0.299 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.021102e-01 0.299 0 0
Cardiogenesis R-HSA-9733709 5.021102e-01 0.299 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.021102e-01 0.299 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.052298e-01 0.297 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.063282e-01 0.296 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.065847e-01 0.295 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.065847e-01 0.295 0 0
Prolactin receptor signaling R-HSA-1170546 5.065847e-01 0.295 0 0
Signal regulatory protein family interactions R-HSA-391160 5.065847e-01 0.295 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.104933e-01 0.292 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.149388e-01 0.288 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.156482e-01 0.288 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.161775e-01 0.287 0 0
Leishmania phagocytosis R-HSA-9664417 5.161775e-01 0.287 0 0
Parasite infection R-HSA-9664407 5.161775e-01 0.287 0 0
Ion transport by P-type ATPases R-HSA-936837 5.197830e-01 0.284 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.217281e-01 0.283 0 0
Signaling by SCF-KIT R-HSA-1433557 5.265229e-01 0.279 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.278257e-01 0.278 0 0
Plus-strand DNA synthesis R-HSA-164525 5.301428e-01 0.276 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.301428e-01 0.276 0 0
Phosphorylation of Emi1 R-HSA-176417 5.301428e-01 0.276 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.301428e-01 0.276 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.301428e-01 0.276 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.301428e-01 0.276 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.301428e-01 0.276 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.301428e-01 0.276 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 5.301428e-01 0.276 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.301428e-01 0.276 0 0
TRAIL signaling R-HSA-75158 5.301428e-01 0.276 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.301428e-01 0.276 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.301428e-01 0.276 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.301428e-01 0.276 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.301428e-01 0.276 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.301428e-01 0.276 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.301428e-01 0.276 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.301428e-01 0.276 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.311748e-01 0.275 0 0
Cellular response to hypoxia R-HSA-1234174 5.341764e-01 0.272 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.353526e-01 0.271 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.353526e-01 0.271 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.353526e-01 0.271 0 0
Formation of the anterior neural plate R-HSA-9823739 5.353526e-01 0.271 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.353526e-01 0.271 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.409698e-01 0.267 0 0
G1 Phase R-HSA-69236 5.435522e-01 0.265 0 0
Cyclin D associated events in G1 R-HSA-69231 5.435522e-01 0.265 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.482638e-01 0.261 0 0
Translation of Structural Proteins R-HSA-9694635 5.506707e-01 0.259 0 0
Long-term potentiation R-HSA-9620244 5.602703e-01 0.252 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.602703e-01 0.252 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.602703e-01 0.252 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.602869e-01 0.252 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.624264e-01 0.250 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.629451e-01 0.250 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.629451e-01 0.250 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.629451e-01 0.250 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.629451e-01 0.250 0 0
Killing mechanisms R-HSA-9664420 5.629451e-01 0.250 0 0
Prolonged ERK activation events R-HSA-169893 5.629451e-01 0.250 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.629451e-01 0.250 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.629451e-01 0.250 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 5.629451e-01 0.250 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.629451e-01 0.250 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.629451e-01 0.250 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.637615e-01 0.249 0 0
FCERI mediated NF-kB activation R-HSA-2871837 5.645534e-01 0.248 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.724862e-01 0.242 0 0
Signaling by LTK in cancer R-HSA-9842640 5.724862e-01 0.242 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.724862e-01 0.242 0 0
Uncoating of the HIV Virion R-HSA-162585 5.724862e-01 0.242 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.724862e-01 0.242 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.724862e-01 0.242 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.724862e-01 0.242 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.724862e-01 0.242 0 0
Abacavir transmembrane transport R-HSA-2161517 5.724862e-01 0.242 0 0
Chylomicron clearance R-HSA-8964026 5.724862e-01 0.242 0 0
Leukotriene receptors R-HSA-391906 5.724862e-01 0.242 0 0
Neurofascin interactions R-HSA-447043 5.724862e-01 0.242 0 0
RUNX2 regulates bone development R-HSA-8941326 5.782183e-01 0.238 0 0
G1/S-Specific Transcription R-HSA-69205 5.782183e-01 0.238 0 0
Mitochondrial biogenesis R-HSA-1592230 5.801104e-01 0.236 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.816252e-01 0.235 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.816252e-01 0.235 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.816252e-01 0.235 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.822769e-01 0.235 0 0
Neuronal System R-HSA-112316 5.892650e-01 0.230 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.893405e-01 0.230 0 0
Coenzyme A biosynthesis R-HSA-196783 5.893405e-01 0.230 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.893405e-01 0.230 0 0
Disorders of Developmental Biology R-HSA-9675151 5.893405e-01 0.230 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.893405e-01 0.230 0 0
Response to metal ions R-HSA-5660526 5.893405e-01 0.230 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.911697e-01 0.228 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.927987e-01 0.227 0 0
Voltage gated Potassium channels R-HSA-1296072 5.961812e-01 0.225 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.961812e-01 0.225 0 0
Signaling by NTRKs R-HSA-166520 6.019197e-01 0.220 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.019805e-01 0.220 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.023101e-01 0.220 0 0
Cristae formation R-HSA-8949613 6.023101e-01 0.220 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.023101e-01 0.220 0 0
Peroxisomal protein import R-HSA-9033241 6.053247e-01 0.218 0 0
GPER1 signaling R-HSA-9634597 6.085446e-01 0.216 0 0
NGF-stimulated transcription R-HSA-9031628 6.085446e-01 0.216 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.110159e-01 0.214 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.110159e-01 0.214 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.110159e-01 0.214 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.110159e-01 0.214 0 0
Recycling of eIF2:GDP R-HSA-72731 6.110159e-01 0.214 0 0
Disinhibition of SNARE formation R-HSA-114516 6.110159e-01 0.214 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.110159e-01 0.214 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.110159e-01 0.214 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.110159e-01 0.214 0 0
VLDL clearance R-HSA-8964046 6.110159e-01 0.214 0 0
Netrin mediated repulsion signals R-HSA-418886 6.110159e-01 0.214 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.136793e-01 0.212 0 0
MET promotes cell motility R-HSA-8875878 6.136793e-01 0.212 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.145305e-01 0.211 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.145305e-01 0.211 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.145305e-01 0.211 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.145305e-01 0.211 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.223079e-01 0.206 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.223079e-01 0.206 0 0
HIV elongation arrest and recovery R-HSA-167287 6.223079e-01 0.206 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.223079e-01 0.206 0 0
Pentose phosphate pathway R-HSA-71336 6.306988e-01 0.200 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.333277e-01 0.198 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.385178e-01 0.195 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.385178e-01 0.195 0 0
Polo-like kinase mediated events R-HSA-156711 6.385178e-01 0.195 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.385178e-01 0.195 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.385178e-01 0.195 0 0
mRNA Capping R-HSA-72086 6.416070e-01 0.193 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 6.416070e-01 0.193 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.460751e-01 0.190 0 0
Minus-strand DNA synthesis R-HSA-164516 6.460751e-01 0.190 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.460751e-01 0.190 0 0
Regulation by c-FLIP R-HSA-3371378 6.460751e-01 0.190 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.460751e-01 0.190 0 0
Dimerization of procaspase-8 R-HSA-69416 6.460751e-01 0.190 0 0
phospho-PLA2 pathway R-HSA-111995 6.460751e-01 0.190 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.460751e-01 0.190 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.460751e-01 0.190 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.460751e-01 0.190 0 0
Fructose biosynthesis R-HSA-5652227 6.460751e-01 0.190 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.460751e-01 0.190 0 0
Alpha-defensins R-HSA-1462054 6.460751e-01 0.190 0 0
Protein localization R-HSA-9609507 6.465242e-01 0.189 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.472288e-01 0.189 0 0
Generation of second messenger molecules R-HSA-202433 6.472288e-01 0.189 0 0
Activation of BH3-only proteins R-HSA-114452 6.602002e-01 0.180 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.613147e-01 0.180 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.613147e-01 0.180 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.632609e-01 0.178 0 0
G1/S Transition R-HSA-69206 6.692282e-01 0.174 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.779764e-01 0.169 0 0
CASP8 activity is inhibited R-HSA-5218900 6.779764e-01 0.169 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.779764e-01 0.169 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.779764e-01 0.169 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.779764e-01 0.169 0 0
Unwinding of DNA R-HSA-176974 6.779764e-01 0.169 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.779764e-01 0.169 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.779764e-01 0.169 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.779764e-01 0.169 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.779764e-01 0.169 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.779764e-01 0.169 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.779764e-01 0.169 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.779764e-01 0.169 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.780850e-01 0.169 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.790975e-01 0.168 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.829408e-01 0.166 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.829408e-01 0.166 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.829408e-01 0.166 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.938108e-01 0.159 0 0
DNA strand elongation R-HSA-69190 6.952624e-01 0.158 0 0
Signaling by WNT in cancer R-HSA-4791275 6.952624e-01 0.158 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.964985e-01 0.157 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.980926e-01 0.156 0 0
RNA Polymerase II Transcription R-HSA-73857 6.994576e-01 0.155 0 0
Integrin cell surface interactions R-HSA-216083 7.014660e-01 0.154 0 0
ABC transporter disorders R-HSA-5619084 7.014660e-01 0.154 0 0
Leishmania infection R-HSA-9658195 7.019697e-01 0.154 0 0
Parasitic Infection Pathways R-HSA-9824443 7.019697e-01 0.154 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.034220e-01 0.153 0 0
Lagging Strand Synthesis R-HSA-69186 7.034220e-01 0.153 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.034220e-01 0.153 0 0
Innate Immune System R-HSA-168249 7.053200e-01 0.152 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.070039e-01 0.151 0 0
Regulation of CDH11 function R-HSA-9762292 7.070039e-01 0.151 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.070039e-01 0.151 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.070039e-01 0.151 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.070039e-01 0.151 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.070039e-01 0.151 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.070039e-01 0.151 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.070039e-01 0.151 0 0
G alpha (z) signalling events R-HSA-418597 7.082680e-01 0.150 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.090818e-01 0.149 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.117368e-01 0.148 0 0
Ion homeostasis R-HSA-5578775 7.209451e-01 0.142 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.209451e-01 0.142 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.227888e-01 0.141 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.227888e-01 0.141 0 0
Serine metabolism R-HSA-977347 7.227888e-01 0.141 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.275156e-01 0.138 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.275156e-01 0.138 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.275156e-01 0.138 0 0
Adipogenesis R-HSA-9843745 7.304751e-01 0.136 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.334165e-01 0.135 0 0
vRNA Synthesis R-HSA-192814 7.334165e-01 0.135 0 0
vRNP Assembly R-HSA-192905 7.334165e-01 0.135 0 0
Synthesis of PI R-HSA-1483226 7.334165e-01 0.135 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.334165e-01 0.135 0 0
Transport of RCbl within the body R-HSA-9758890 7.334165e-01 0.135 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.334165e-01 0.135 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.334165e-01 0.135 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.334165e-01 0.135 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.358290e-01 0.133 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.358290e-01 0.133 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.410758e-01 0.130 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.410758e-01 0.130 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.410758e-01 0.130 0 0
Signaling by KIT in disease R-HSA-9669938 7.410758e-01 0.130 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.410758e-01 0.130 0 0
LDL clearance R-HSA-8964038 7.410758e-01 0.130 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.426086e-01 0.129 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.426086e-01 0.129 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.488276e-01 0.126 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.488276e-01 0.126 0 0
Signalling to ERKs R-HSA-187687 7.570281e-01 0.121 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.574494e-01 0.121 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.574494e-01 0.121 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.574494e-01 0.121 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.574494e-01 0.121 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.574494e-01 0.121 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.574494e-01 0.121 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.574494e-01 0.121 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.574494e-01 0.121 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.574494e-01 0.121 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.583201e-01 0.120 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.583201e-01 0.120 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.583201e-01 0.120 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.583201e-01 0.120 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.707879e-01 0.113 0 0
RNA Polymerase III Transcription R-HSA-74158 7.707879e-01 0.113 0 0
GPVI-mediated activation cascade R-HSA-114604 7.707879e-01 0.113 0 0
Gluconeogenesis R-HSA-70263 7.733437e-01 0.112 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.745611e-01 0.111 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.745611e-01 0.111 0 0
Interleukin-6 family signaling R-HSA-6783589 7.745611e-01 0.111 0 0
Ca2+ pathway R-HSA-4086398 7.748164e-01 0.111 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.748164e-01 0.111 0 0
Integration of energy metabolism R-HSA-163685 7.767290e-01 0.110 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.793171e-01 0.108 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.793171e-01 0.108 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.793171e-01 0.108 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.793171e-01 0.108 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.793171e-01 0.108 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.793171e-01 0.108 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.793171e-01 0.108 0 0
Signaling by LTK R-HSA-9842663 7.793171e-01 0.108 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.793171e-01 0.108 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.793171e-01 0.108 0 0
Polymerase switching R-HSA-69091 7.793171e-01 0.108 0 0
Leading Strand Synthesis R-HSA-69109 7.793171e-01 0.108 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.793171e-01 0.108 0 0
Pervasive developmental disorders R-HSA-9005895 7.793171e-01 0.108 0 0
Disorders of Nervous System Development R-HSA-9697154 7.793171e-01 0.108 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.793171e-01 0.108 0 0
Mitochondrial protein import R-HSA-1268020 7.887069e-01 0.103 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.898395e-01 0.102 0 0
Laminin interactions R-HSA-3000157 7.898395e-01 0.102 0 0
Tight junction interactions R-HSA-420029 7.898395e-01 0.102 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.898395e-01 0.102 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.898395e-01 0.102 0 0
Azathioprine ADME R-HSA-9748787 7.959353e-01 0.099 0 0
Elastic fibre formation R-HSA-1566948 7.963922e-01 0.099 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.986491e-01 0.098 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.992144e-01 0.097 0 0
Formation of axial mesoderm R-HSA-9796292 7.992144e-01 0.097 0 0
Frs2-mediated activation R-HSA-170968 7.992144e-01 0.097 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.992144e-01 0.097 0 0
Processing of SMDT1 R-HSA-8949664 7.992144e-01 0.097 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.992144e-01 0.097 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.992144e-01 0.097 0 0
Maturation of nucleoprotein R-HSA-9683610 7.992144e-01 0.097 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.992144e-01 0.097 0 0
MET activates PTK2 signaling R-HSA-8874081 8.041969e-01 0.095 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.041969e-01 0.095 0 0
Sphingolipid catabolism R-HSA-9845614 8.041969e-01 0.095 0 0
TRP channels R-HSA-3295583 8.041969e-01 0.095 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.082715e-01 0.092 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.082715e-01 0.092 0 0
Signaling by ALK R-HSA-201556 8.082715e-01 0.092 0 0
Removal of the Flap Intermediate R-HSA-69166 8.173188e-01 0.088 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.173188e-01 0.088 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.173188e-01 0.088 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.173188e-01 0.088 0 0
Hydrolysis of LPC R-HSA-1483115 8.173188e-01 0.088 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.173188e-01 0.088 0 0
HDL assembly R-HSA-8963896 8.173188e-01 0.088 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.173188e-01 0.088 0 0
Zinc transporters R-HSA-435354 8.173188e-01 0.088 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.173188e-01 0.088 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.176750e-01 0.087 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.176750e-01 0.087 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.176750e-01 0.087 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.176750e-01 0.087 0 0
HIV Transcription Elongation R-HSA-167169 8.195602e-01 0.086 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.195602e-01 0.086 0 0
Interleukin-2 family signaling R-HSA-451927 8.195602e-01 0.086 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.195602e-01 0.086 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.195602e-01 0.086 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.195602e-01 0.086 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.263788e-01 0.083 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.269862e-01 0.083 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.281671e-01 0.082 0 0
SLC transporter disorders R-HSA-5619102 8.294579e-01 0.081 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.302778e-01 0.081 0 0
Maturation of spike protein R-HSA-9694548 8.302778e-01 0.081 0 0
Telomere Extension By Telomerase R-HSA-171319 8.303156e-01 0.081 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.303156e-01 0.081 0 0
Pyroptosis R-HSA-5620971 8.303156e-01 0.081 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.337917e-01 0.079 0 0
Erythropoietin activates RAS R-HSA-9027284 8.337917e-01 0.079 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.337917e-01 0.079 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.337917e-01 0.079 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.337917e-01 0.079 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.337917e-01 0.079 0 0
DNA Damage Reversal R-HSA-73942 8.337917e-01 0.079 0 0
Protein lipoylation R-HSA-9857492 8.337917e-01 0.079 0 0
p38MAPK events R-HSA-171007 8.337917e-01 0.079 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.337917e-01 0.079 0 0
Other semaphorin interactions R-HSA-416700 8.337917e-01 0.079 0 0
Signaling by Activin R-HSA-1502540 8.337917e-01 0.079 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.337917e-01 0.079 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.404440e-01 0.075 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.404440e-01 0.075 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.404440e-01 0.075 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.404440e-01 0.075 0 0
Signaling by Erythropoietin R-HSA-9006335 8.421602e-01 0.075 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.421602e-01 0.075 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.421602e-01 0.075 0 0
Glucagon-type ligand receptors R-HSA-420092 8.421602e-01 0.075 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.454443e-01 0.073 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.464089e-01 0.072 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 8.487801e-01 0.071 0 0
Attachment and Entry R-HSA-9678110 8.487801e-01 0.071 0 0
Atorvastatin ADME R-HSA-9754706 8.487801e-01 0.071 0 0
Activation of the pre-replicative complex R-HSA-68962 8.532494e-01 0.069 0 0
DAP12 signaling R-HSA-2424491 8.532494e-01 0.069 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.532494e-01 0.069 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.532494e-01 0.069 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.577642e-01 0.067 0 0
Gastrulation R-HSA-9758941 8.621617e-01 0.064 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.624177e-01 0.064 0 0
Fibronectin matrix formation R-HSA-1566977 8.624177e-01 0.064 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.624177e-01 0.064 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.624177e-01 0.064 0 0
Galactose catabolism R-HSA-70370 8.624177e-01 0.064 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.624177e-01 0.064 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.636232e-01 0.064 0 0
Cargo concentration in the ER R-HSA-5694530 8.636232e-01 0.064 0 0
Downstream signal transduction R-HSA-186763 8.636232e-01 0.064 0 0
G0 and Early G1 R-HSA-1538133 8.733203e-01 0.059 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.733203e-01 0.059 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.733203e-01 0.059 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.748261e-01 0.058 0 0
Extension of Telomeres R-HSA-180786 8.759964e-01 0.057 0 0
Regulation of beta-cell development R-HSA-186712 8.759964e-01 0.057 0 0
G-protein beta:gamma signalling R-HSA-397795 8.823785e-01 0.054 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.823785e-01 0.054 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.829499e-01 0.054 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.829499e-01 0.054 0 0
Diseases of DNA repair R-HSA-9675135 8.837112e-01 0.054 0 0
Signaling by FGFR in disease R-HSA-1226099 8.851143e-01 0.053 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.861161e-01 0.053 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.861161e-01 0.053 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 8.861161e-01 0.053 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.861161e-01 0.053 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.861161e-01 0.053 0 0
Tie2 Signaling R-HSA-210993 8.861161e-01 0.053 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.861161e-01 0.053 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.861161e-01 0.053 0 0
Generic Transcription Pathway R-HSA-212436 8.875341e-01 0.052 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.878557e-01 0.052 0 0
Aquaporin-mediated transport R-HSA-445717 8.895615e-01 0.051 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.895615e-01 0.051 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.908339e-01 0.050 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.908339e-01 0.050 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.908339e-01 0.050 0 0
Iron uptake and transport R-HSA-917937 8.911109e-01 0.050 0 0
FOXO-mediated transcription R-HSA-9614085 8.930351e-01 0.049 0 0
Signaling by PDGF R-HSA-186797 8.958440e-01 0.048 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.963884e-01 0.048 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.963884e-01 0.048 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.963884e-01 0.048 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.963884e-01 0.048 0 0
Other interleukin signaling R-HSA-449836 8.963884e-01 0.048 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.963884e-01 0.048 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.963884e-01 0.048 0 0
Maturation of nucleoprotein R-HSA-9694631 8.963884e-01 0.048 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.963884e-01 0.048 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.978625e-01 0.047 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.987217e-01 0.046 0 0
eNOS activation R-HSA-203615 8.987217e-01 0.046 0 0
Signal amplification R-HSA-392518 8.987217e-01 0.046 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.987217e-01 0.046 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.987217e-01 0.046 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.987217e-01 0.046 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.057347e-01 0.043 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.057347e-01 0.043 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.057347e-01 0.043 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.057347e-01 0.043 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.057347e-01 0.043 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.057347e-01 0.043 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.057347e-01 0.043 0 0
Creatine metabolism R-HSA-71288 9.057347e-01 0.043 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.057347e-01 0.043 0 0
Pregnenolone biosynthesis R-HSA-196108 9.057347e-01 0.043 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.057347e-01 0.043 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.060754e-01 0.043 0 0
PERK regulates gene expression R-HSA-381042 9.060754e-01 0.043 0 0
PI3K Cascade R-HSA-109704 9.104438e-01 0.041 0 0
Post-translational protein modification R-HSA-597592 9.129146e-01 0.040 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.129272e-01 0.040 0 0
Glycosphingolipid transport R-HSA-9845576 9.129272e-01 0.040 0 0
Triglyceride catabolism R-HSA-163560 9.129272e-01 0.040 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.129272e-01 0.040 0 0
Extracellular matrix organization R-HSA-1474244 9.141972e-01 0.039 0 0
G-protein activation R-HSA-202040 9.142384e-01 0.039 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.142384e-01 0.039 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.142384e-01 0.039 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.142384e-01 0.039 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.142384e-01 0.039 0 0
Signalling to RAS R-HSA-167044 9.142384e-01 0.039 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.142384e-01 0.039 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.216015e-01 0.035 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.216015e-01 0.035 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.219755e-01 0.035 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.219755e-01 0.035 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.219755e-01 0.035 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.219755e-01 0.035 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.219755e-01 0.035 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.219755e-01 0.035 0 0
Attachment and Entry R-HSA-9694614 9.219755e-01 0.035 0 0
Ribavirin ADME R-HSA-9755088 9.219755e-01 0.035 0 0
Metabolism of proteins R-HSA-392499 9.240876e-01 0.034 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.252462e-01 0.034 0 0
Purine salvage R-HSA-74217 9.252462e-01 0.034 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.252533e-01 0.034 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.263027e-01 0.033 0 0
Mitochondrial protein degradation R-HSA-9837999 9.263027e-01 0.033 0 0
Nucleotide biosynthesis R-HSA-8956320 9.266899e-01 0.033 0 0
Transcription of the HIV genome R-HSA-167172 9.273222e-01 0.033 0 0
Platelet homeostasis R-HSA-418346 9.276198e-01 0.033 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.286435e-01 0.032 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.290150e-01 0.032 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.290150e-01 0.032 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.290150e-01 0.032 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.290150e-01 0.032 0 0
Fructose metabolism R-HSA-5652084 9.290150e-01 0.032 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.290150e-01 0.032 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.323240e-01 0.030 0 0
Cardiac conduction R-HSA-5576891 9.349199e-01 0.029 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.354197e-01 0.029 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.354197e-01 0.029 0 0
Formation of the ureteric bud R-HSA-9830674 9.354197e-01 0.029 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.354197e-01 0.029 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.354197e-01 0.029 0 0
Carnitine shuttle R-HSA-200425 9.354197e-01 0.029 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.354197e-01 0.029 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.401891e-01 0.027 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.412469e-01 0.026 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.412469e-01 0.026 0 0
Complex III assembly R-HSA-9865881 9.412469e-01 0.026 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.412469e-01 0.026 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.412469e-01 0.026 0 0
tRNA processing R-HSA-72306 9.421167e-01 0.026 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.432487e-01 0.025 0 0
Regulation of insulin secretion R-HSA-422356 9.436652e-01 0.025 0 0
IRS-mediated signalling R-HSA-112399 9.441510e-01 0.025 0 0
Interferon gamma signaling R-HSA-877300 9.446839e-01 0.025 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.447535e-01 0.025 0 0
Intra-Golgi traffic R-HSA-6811438 9.451147e-01 0.025 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.465486e-01 0.024 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.465486e-01 0.024 0 0
G protein gated Potassium channels R-HSA-1296059 9.465486e-01 0.024 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.465486e-01 0.024 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.465486e-01 0.024 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.465486e-01 0.024 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.465486e-01 0.024 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.465486e-01 0.024 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.478681e-01 0.023 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.478681e-01 0.023 0 0
Activation of GABAB receptors R-HSA-991365 9.492321e-01 0.023 0 0
GABA B receptor activation R-HSA-977444 9.492321e-01 0.023 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.492321e-01 0.023 0 0
Triglyceride metabolism R-HSA-8979227 9.513536e-01 0.022 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.513536e-01 0.022 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.513722e-01 0.022 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.513722e-01 0.022 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.513722e-01 0.022 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.513722e-01 0.022 0 0
Urea cycle R-HSA-70635 9.513722e-01 0.022 0 0
Abacavir ADME R-HSA-2161522 9.513722e-01 0.022 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.530269e-01 0.021 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.544717e-01 0.020 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.557608e-01 0.020 0 0
Triglyceride biosynthesis R-HSA-75109 9.557608e-01 0.020 0 0
Insulin processing R-HSA-264876 9.557608e-01 0.020 0 0
DAP12 interactions R-HSA-2172127 9.565994e-01 0.019 0 0
Proteasome assembly R-HSA-9907900 9.565994e-01 0.019 0 0
Amine ligand-binding receptors R-HSA-375280 9.565994e-01 0.019 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.576815e-01 0.019 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.597535e-01 0.018 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.597535e-01 0.018 0 0
Prednisone ADME R-HSA-9757110 9.597535e-01 0.018 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.597535e-01 0.018 0 0
Insulin receptor recycling R-HSA-77387 9.597535e-01 0.018 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.597535e-01 0.018 0 0
Pyrimidine salvage R-HSA-73614 9.597535e-01 0.018 0 0
Somitogenesis R-HSA-9824272 9.598877e-01 0.018 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.605480e-01 0.017 0 0
Cholesterol biosynthesis R-HSA-191273 9.612321e-01 0.017 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.629363e-01 0.016 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.633861e-01 0.016 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.633861e-01 0.016 0 0
Platelet calcium homeostasis R-HSA-418360 9.633861e-01 0.016 0 0
IGF1R signaling cascade R-HSA-2428924 9.657420e-01 0.015 0 0
Insulin receptor signalling cascade R-HSA-74751 9.657420e-01 0.015 0 0
Neddylation R-HSA-8951664 9.663039e-01 0.015 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.666910e-01 0.015 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.666910e-01 0.015 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.666910e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.666910e-01 0.015 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.680904e-01 0.014 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.720157e-01 0.012 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.724333e-01 0.012 0 0
Potassium Channels R-HSA-1296071 9.729433e-01 0.012 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.730474e-01 0.012 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.749221e-01 0.011 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.749221e-01 0.011 0 0
The phototransduction cascade R-HSA-2514856 9.751247e-01 0.011 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.771862e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.771862e-01 0.010 0 0
Heme degradation R-HSA-189483 9.771862e-01 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.777179e-01 0.010 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.785467e-01 0.009 0 0
RA biosynthesis pathway R-HSA-5365859 9.792461e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.792461e-01 0.009 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.792461e-01 0.009 0 0
ECM proteoglycans R-HSA-3000178 9.792782e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.807340e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.811201e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.811201e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.811201e-01 0.008 0 0
Paracetamol ADME R-HSA-9753281 9.819887e-01 0.008 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.828250e-01 0.008 0 0
Metabolism of folate and pterines R-HSA-196757 9.843760e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.845161e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.846917e-01 0.007 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.857871e-01 0.006 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.857871e-01 0.006 0 0
Signaling by Insulin receptor R-HSA-74752 9.866563e-01 0.006 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.866618e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.869984e-01 0.006 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.870707e-01 0.006 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.870707e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.875837e-01 0.005 0 0
GABA receptor activation R-HSA-977443 9.880211e-01 0.005 0 0
Metabolism of polyamines R-HSA-351202 9.880211e-01 0.005 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.882385e-01 0.005 0 0
Nucleotide salvage R-HSA-8956321 9.889652e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.896831e-01 0.005 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.902674e-01 0.004 0 0
HIV Transcription Initiation R-HSA-167161 9.902674e-01 0.004 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.902674e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.902674e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.911467e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.914440e-01 0.004 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.919465e-01 0.004 0 0
Defensins R-HSA-1461973 9.919465e-01 0.004 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.919465e-01 0.004 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.926741e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.926741e-01 0.003 0 0
Nicotinate metabolism R-HSA-196807 9.932792e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.932792e-01 0.003 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.933361e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.936727e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.936727e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.944860e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.945108e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.947653e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.949843e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.951850e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.953647e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.953647e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.954376e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.962251e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.962556e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.965948e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.965948e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.968487e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.973269e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.976753e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.978621e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.980268e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.983242e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.983912e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.983912e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.985367e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.985367e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.987894e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.988989e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.989533e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.990209e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.990872e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.990892e-01 0.000 0 0
Kidney development R-HSA-9830369 9.991716e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.991716e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.992377e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.992428e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.992465e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.993505e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.993767e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.994331e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994331e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.995658e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997082e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997346e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.997346e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998055e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.998208e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998349e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.998639e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998770e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998848e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998898e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999195e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999318e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999349e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999422e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999463e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999603e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999710e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999765e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999853e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999941e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999949e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999973e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999977e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999977e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999980e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999980e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999981e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999987e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999988e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999988e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999996e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways