GRK7

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A4FU28 S138 Sugiyama CTAGE9 EKAAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKS
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A6NMY6 S127 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
A6NMY6 T123 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O14974 S912 Sugiyama PPP1R12A MBS MYPT1 TssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDSTDF
O14980 S1031 Sugiyama XPO1 CRM1 FKEHLRDFLVQIKEFAGEDtsDLFLEEREIALRQADEEKHK
O14980 T1030 Sugiyama XPO1 CRM1 AFKEHLRDFLVQIKEFAGEDtsDLFLEEREIALRQADEEKH
O43719 S600 Sugiyama HTATSF1 EKELHENVLDKELEENDsENsEFEDDGsEKVLDEEGsEREF
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O60610 S542 Sugiyama DIAPH1 DIAP1 ALHSEKQQIATEKQDLEAEVsQLtGEVAKLTKELEDAKKEM
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75822 S127 Sugiyama EIF3J EIF3S1 PRO0391 VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O94888 S288 Sugiyama UBXN7 KIAA0794 UBXD7 sssPPKKCARsEsLIDAsEDsQLEAAIRASLQETHFDstQT
O95155 S118 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 QsLsRsQsMDIDGVSCEKsMsQVDVDsGIENMEVDENDRRE
O95155 S124 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 QsMDIDGVSCEKsMsQVDVDsGIENMEVDENDRREKRsLsD
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95757 Y600 Sugiyama HSPA4L APG1 HSPH3 OSP94 IDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERNDA
P00558 S415 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGGAsLELLEGKVLPGVDALsNI__________________
P02533 S321 Sugiyama KRT14 DAEEWFFTKTEELNREVATNsELVQSGKSEISELRRTMQNL
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S434 Sugiyama ALPP PLAP LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETH
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S304 Sugiyama RPLP0 AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355 S127 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 T123 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
P07858 S323 Sugiyama CTSB CPSB DWGDNGFFKILRGQDHCGIEsEVVAGIPRTDQYWEKI____
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08195 S403 Sugiyama SLC3A2 MDU1 SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08195 T106 Sugiyama SLC3A2 MDU1 SDPPALASKNAEVTGTMsQDtEVDMKEVELNELEPEKQPMN
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08758 S136 Sugiyama ANXA5 ANX5 ENX2 PP4 sRtPEELRAIKQVyEEEyGssLEDDVVGDTSGYYQRMLVVL
P0CAP2 S144 Sugiyama POLR2M GRINL1A SQTSQNQGLGRPTLEGDEETsEVEYTVNKGPASSNRDRVPP
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG41 S138 Sugiyama CTAGE8 EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 S54 Sugiyama TUBA3C TUBA2 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P10696 S431 Sugiyama ALPG ALPPL ALPPL2 LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETH
P10809 S383 Sugiyama HSPD1 HSP60 DKAQIEKRIQEIIEQLDVttsEyEKEKLNERLAKLsDGVAV
P10809 T382 Sugiyama HSPD1 HSP60 GDKAQIEKRIQEIIEQLDVttsEyEKEKLNERLAKLsDGVA
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S578 Sugiyama EEF2 EF2 LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK
P13639 Y579 Sugiyama EEF2 EF2 KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13797 S110 Sugiyama PLS3 AKTFRKAINRKEGICALGGTsELssEGtQHsysEEEKyAFV
P13797 S120 Sugiyama PLS3 KEGICALGGTsELssEGtQHsysEEEKyAFVNWINKALEND
P13797 S122 Sugiyama PLS3 GICALGGTsELssEGtQHsysEEEKyAFVNWINKALENDPD
P13798 S185 Sugiyama APEH D3F15S2 D3S48E DNF15S2 VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P13861 S80 Sugiyama PRKAR2A PKR2 PRKAR2 GHPPPEPGPDRVADAKGDsEsEEDEDLEVPVPsRFNRRVsV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S306 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TETVEEPMEEEEAAKEEKEEsDDEAAVEEEEEEKKPKTKKV
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P16333 S96 Sugiyama NCK1 NCK GIGKVKRKPsVPDsAsPADDsFVDPGERLyDLNMPAyVKFN
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17096 S103 Sugiyama HMGA1 HMGIY PRGRPKKLEKEEEEGIsQEssEEEQ________________
P17812 S578 Sugiyama CTPS1 CTPS GCRLsPRDtysDRsGsssPDsEItELKFPsINHD_______
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P17987 Y545 Sugiyama TCP1 CCT1 CCTA LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23396 S35 Sugiyama RPS3 OK/SW-cl.26 GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P25205 S711 Sugiyama MCM3 RRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADsQEt
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P25788 Y239 Sugiyama PSMA3 HC8 PSC8 ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P27797 S189 Sugiyama CALR CRTC THLytLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIK
P27816 S643 Sugiyama MAP4 IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P27824 S554 Sugiyama CANX EKDKGDEEEEGEEKLEEKQKsDAEEDGGtVsQEEEDRKPKA
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29966 S27 Sugiyama MARCKS MACS PRKCSL KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34932 S414 Sugiyama HSPA4 APG2 HSPH2 ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P41227 S213 Sugiyama NAA10 ARD1 ARD1A TE2 ACREEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDs
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43003 S512 Sugiyama SLC1A3 EAAT1 GLAST GLAST1 GIVEHLSRHELKNRDVEMGNsVIEENEMKKPyQLIAQDNET
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P47712 S731 Sugiyama PLA2G4A CPLA2 PLA2G4 AMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA__
P47756 S204 Sugiyama CAPZB sGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMENKI
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49321 S127 Sugiyama NASP GNALEGVHVEEEEGEKtEDEsLVENNDNIDEEAREELREQV
P49321 S432 Sugiyama NASP EKVRAKLVPsQEEtKLsVEEsEAAGDGVDTKVAQGAtEKsP
P49321 S497 Sugiyama NASP tEGsEEDDKENDKtEEMPNDsVLENKsLQENEEEEIGNLEL
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49588 S188 Sugiyama AARS1 AARS PGNMKDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDD
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50502 S79 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 KPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDAPQEM
P50851 S993 Sugiyama LRBA BGL CDC4L LBA QPDtKDsPVCPHFttNGNENssIEKTSsLEsASNIELQTTN
P50897 S262 Sugiyama PPT1 CLN1 PPT EWFGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVF
P51580 S14 Sugiyama TPMT _______MDGTRTSLDIEEysDtEVQKNQVLTLEEWQDKWV
P52789 S889 Sugiyama HK2 PHFAKVMHETVKDLAPKCDVsFLQsEDGSGKGAALITAVAC
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S17 Sugiyama SUB1 PC4 RPO2TC1 ____MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPV
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P55060 T341 Sugiyama CSE1L CAS XPO2 LASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEA
P56385 S66 Sugiyama ATP5ME ATP5I ATP5K EEKKKQDELKRIARELAEDDsILK_________________
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60900 S177 Sugiyama PSMA6 PROS27 AGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTVET
P60900 T176 Sugiyama PSMA6 PROS27 PAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTVE
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63146 S148 Sugiyama UBE2B RAD6B UBCH1 QLYQENKREYEKRVsAIVEQsWNDS________________
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 S54 Sugiyama TUBA1B GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q04695 S290 Sugiyama KRT17 DAEDWFFsKTEELNREVATNsELVQSGKSEISELRRTMQAL
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q08211 S125 Sugiyama DHX9 DDX9 LKP NDH2 LPttMGGPLPPHLALKAENNsEVGAsGyGVPGPTWDRGANL
Q13144 S527 Sugiyama EIF2B5 EIF2BE EEELQQNLWGLKINMEEEsEsESEQSMDsEEPDsRGGsPQM
Q13263 S479 Sugiyama TRIM28 KAP1 RNF96 TIF1B ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13371 S296 Sugiyama PDCL PHLOP1 PhLP1 EKEVLVLTSVRNsAtCHsEDsDLEID_______________
Q13428 S85 Sugiyama TCOF1 AEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRL
Q13428 S87 Sugiyama TCOF1 EDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAs
Q13428 S88 Sugiyama TCOF1 DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13547 S421 Sugiyama HDAC1 RPD3L1 PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK
Q13547 S423 Sugiyama HDAC1 RPD3L1 KRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAKRV
Q14151 S207 Sugiyama SAFB2 KIAA0138 FKNtLEtssLNFKVtPDIEEsLLEPENEKILDILGEtCKsE
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14203 S417 Sugiyama DCTN1 KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE
Q14203 T422 Sugiyama DCTN1 LEVVRQQRERLQEELsQAEstIDELKEQVDAALGAEEMVEM
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14980 S863 Sugiyama NUMA1 NMP22 NUMA EKARQELQEAKEKVAGIEsHsELQISRQQNELAELHANLAR
Q14C86 S576 Sugiyama GAPVD1 GAPEX5 KIAA1521 RAP6 HGKPDKTLRFSLCsDNLEGIsEGPSNRSNSVSSLDLEGESV
Q15003 S733 Sugiyama NCAPH BRRN BRRN1 CAPH KIAA0074 ACLLHLANEKNLKLEGtEDLsDVLVRQGD____________
Q15084 S428 Sugiyama PDIA6 ERP5 P5 TXNDC7 EREPWDGRDGELPVEDDIDLsDVELDDLGKDEL________
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q16204 S327 Sugiyama CCDC6 D10S170 TST1 KLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGLRP
Q16625 S471 EPSD|PSP OCLN DEINKELSRLDKELDDYREEsEEyMAAADEYNRLKQVKGsA
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6P996 S779 Sugiyama PDXDC1 KIAA0251 QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 S54 Sugiyama TUBA3E GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S54 Sugiyama TUBA1A TUBA3 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7Z3K6 S53 Sugiyama MIER3 YDDERTLEEEEMMDEGKNFssEIEDLEKEGTMPLEDLLAFY
Q86UF2 S138 Sugiyama CTAGE6 CTAGE6P EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IX94 S138 Sugiyama CTAGE4 EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBS9 S292 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NHW5 S304 Sugiyama RPLP0P6 DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WTQ7 S36 Sugiyama GRK7 GPRK7 YLQARKPsDCDSKELQRRRRsLALPGLQGCAELRQKLSLNF
Q8WTQ7 S490 SIGNOR|Sugiyama GRK7 GPRK7 PFVPDPSVVYAKDIAEIDDFsEVRGVEFDDKDKQFFKNFAT
Q8WVC0 S66 Sugiyama LEO1 RDL DQDERGDSGQPSNKELFGDDsEDEGAsHHsGSDNHSERSDN
Q8WVJ2 S153 Sugiyama NUDCD2 GFDFsGAEIsGNytKGGPDFsNLEK________________
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q92769 S424 Sugiyama HDAC2 KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK
Q92973 S339 Sugiyama TNPO1 KPNB2 MIP1 TRN SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96K76 S903 Sugiyama USP47 LSLQQQQDGDNGDssKstEtsDFENIEsPLNERDsSAsVDN
Q96S66 S59 Sugiyama CLCC1 KIAA0761 MCLC MRKSQAKYGISGEKDVSPDLsCADEIsECyHKLDSLTYKID
Q96S66 Y68 Sugiyama CLCC1 KIAA0761 MCLC ISGEKDVSPDLsCADEIsECyHKLDSLTYKIDECEKKKRED
Q96SB4 S334 Sugiyama SRPK1 ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI
Q96SB4 T341 Sugiyama SRPK1 PPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEINCNGVIE
Q99459 T510 Sugiyama CDC5L KIAA0432 PCDC5RP FEIVLPENAEKELEEREIDDtyIEDAADVDARKQAIRDAER
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99614 S83 Sugiyama TTC1 TPR1 FHDCsAsFEEEPGADKVENKsNEDVNssELDEEyLIELEKN
Q99614 S90 Sugiyama TTC1 TPR1 FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q99733 S121 Sugiyama NAP1L4 NAP2 PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 S54 Sugiyama TUBA1C TUBA6 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BVS4 S332 Sugiyama RIOK2 RIO2 DDELLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsEN
Q9BVS4 S335 Sugiyama RIOK2 RIO2 LLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsE
Q9BW91 S343 Sugiyama NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BXJ9 T850 Sugiyama NAA15 GA19 NARG1 NATH TBDN100 KLFPYALAFMPPGYEEDMKItVNGDssAEAEELANEI____
Q9BXK5 S420 Sugiyama BCL2L13 MIL1 CD003 PALEPTETLLsEKEINAREEsLVEELsPAsEKKPVPPSEGK
Q9BXW9 S891 Sugiyama FANCD2 FACD KQKTDGSKTSssDtLsEEKNsECDPtPsHRGQLNKEFTGKE
Q9BXW9 T884 Sugiyama FANCD2 FACD KKGKIERKQKTDGSKTSssDtLsEEKNsECDPtPsHRGQLN
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H2U2 S309 Sugiyama PPA2 HSPC124 NCTNVQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVW
Q9HAU0 S832 Sugiyama PLEKHA5 KIAA1686 PEPP2 ELttVAEVDEsNGEEKsEPVsEIEtsVVKGSHFPVGVVPPR
Q9HCN4 S338 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 HPsDLILtRGTLDEEDEEADsDtDDIDHRVTEESHEEPAFQ
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30 S168 Sugiyama DDX21 PKLKNGFPHPEPDCNPsEAAsEEsNsEIEQEIPVEQKEGAF
Q9NRF8 S574 Sugiyama CTPS2 YLQQGCKLsssDRysDAsDDsFSEPRIAELEIS________
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9NYL9 S25 Sugiyama TMOD3 FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL
Q9NZ53 S596 Sugiyama PODXL2 UNQ1861/PRO3742 ALNGPGsWGALMGGKRDPEDsDVFEEDtHL___________
Q9NZ53 T603 Sugiyama PODXL2 UNQ1861/PRO3742 WGALMGGKRDPEDsDVFEEDtHL__________________
Q9P2I0 S423 Sugiyama CPSF2 CPSF100 KIAA1367 KEAAKKLEQSKEADIDssDEsDIEEDIDQPSAHKTKHDLMM
Q9Y265 S434 Sugiyama RUVBL1 INO80H NMP238 TIP49 TIP49A NLLAKINGKDSIEKEHVEEIsELFyDAKSSAKILADQQDKY
Q9Y266 S285 Sugiyama NUDC NtKKINPENsKLsDLDsEtRsMVEKMMYDQRQKsMGLPtsD
Q9Y266 T283 Sugiyama NUDC EINtKKINPENsKLsDLDsEtRsMVEKMMYDQRQKsMGLPt
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2R5 S127 Sugiyama MRPS17 RPMS17 HSPC011 ESPLSSETTQLSKNLEELNIssAQ_________________
Q9Y3F4 S335 Sugiyama STRAP MAWD UNRIP LAKPKIGFPETTEEELEEIAsENsDCIFPSAPDVKA_____
Q9Y4L1 S763 Sugiyama HYOU1 GRP170 HSPH4 ORP150 LEAFIFEtQDKLyQPEyQEVsTEEQREEISGKLSAASTWLE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.826131e-10 9.166 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.075038e-09 8.216 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.146041e-08 7.668 0 0
Cell Cycle, Mitotic R-HSA-69278 1.946768e-07 6.711 0 0
M Phase R-HSA-68886 3.915575e-07 6.407 0 0
Chromatin organization R-HSA-4839726 3.721753e-07 6.429 0 0
Axon guidance R-HSA-422475 8.675729e-07 6.062 0 0
Nervous system development R-HSA-9675108 1.182141e-06 5.927 0 0
Metabolism of RNA R-HSA-8953854 1.347005e-06 5.871 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.411201e-06 5.850 0 0
EPH-Ephrin signaling R-HSA-2682334 4.205085e-06 5.376 0 0
Mitotic Prometaphase R-HSA-68877 4.056789e-06 5.392 0 0
Chromatin modifying enzymes R-HSA-3247509 4.340051e-06 5.363 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.602655e-06 5.337 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.882787e-06 5.103 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.649219e-06 5.016 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.439453e-05 4.842 0 0
Recycling pathway of L1 R-HSA-437239 1.803053e-05 4.744 0 0
mRNA Splicing R-HSA-72172 1.718303e-05 4.765 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.074547e-05 4.683 0 0
Signaling by Hippo R-HSA-2028269 2.013982e-05 4.696 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.393459e-05 4.621 0 0
Aggrephagy R-HSA-9646399 2.393459e-05 4.621 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.926346e-05 4.534 0 0
Mitotic Anaphase R-HSA-68882 3.306865e-05 4.481 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.677571e-05 4.434 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.035523e-05 4.394 0 0
Gene expression (Transcription) R-HSA-74160 4.111302e-05 4.386 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.935978e-05 4.307 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.105075e-05 4.214 0 0
Post NMDA receptor activation events R-HSA-438064 6.156939e-05 4.211 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.450446e-05 4.190 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.788180e-05 4.056 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.416949e-05 4.026 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.051767e-04 3.978 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.296892e-04 3.887 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.296892e-04 3.887 0 0
Ephrin signaling R-HSA-3928664 1.379907e-04 3.860 0 0
Apoptotic execution phase R-HSA-75153 1.347261e-04 3.871 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.379907e-04 3.860 0 0
L1CAM interactions R-HSA-373760 1.565958e-04 3.805 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.679374e-04 3.775 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.710410e-04 3.767 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.714628e-04 3.766 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.904078e-04 3.720 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.944118e-04 3.711 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.127079e-04 3.672 0 0
Cellular response to heat stress R-HSA-3371556 2.989855e-04 3.524 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.989855e-04 3.524 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.943487e-04 3.531 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.082247e-04 3.511 0 0
Regulation of TP53 Activity R-HSA-5633007 3.320169e-04 3.479 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.488363e-04 3.457 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.488363e-04 3.457 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.521242e-04 3.453 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.969503e-04 3.401 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.850893e-04 3.414 0 0
Selective autophagy R-HSA-9663891 4.058225e-04 3.392 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.462421e-04 3.350 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.451511e-04 3.351 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.609493e-04 3.336 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.700718e-04 3.328 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.141053e-04 3.289 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.815647e-04 3.235 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.815647e-04 3.235 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.776088e-04 3.169 0 0
Gap junction trafficking and regulation R-HSA-157858 7.006537e-04 3.154 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.118046e-04 3.148 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.370517e-04 3.133 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.538345e-04 3.123 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.069009e-04 3.093 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.327352e-04 3.030 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.059704e-03 2.975 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.059704e-03 2.975 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.083710e-03 2.965 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.089136e-03 2.963 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.202306e-03 2.920 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.143565e-03 2.942 0 0
Death Receptor Signaling R-HSA-73887 1.201713e-03 2.920 0 0
mRNA 3'-end processing R-HSA-72187 1.208177e-03 2.918 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.241399e-03 2.906 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.241399e-03 2.906 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.464622e-03 2.834 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.707968e-03 2.768 0 0
Separation of Sister Chromatids R-HSA-2467813 1.695699e-03 2.771 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.708833e-03 2.767 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.713344e-03 2.766 0 0
Regulation of KIT signaling R-HSA-1433559 1.713344e-03 2.766 0 0
Signaling by ERBB2 R-HSA-1227986 1.843096e-03 2.734 0 0
Kinesins R-HSA-983189 1.843096e-03 2.734 0 0
Gap junction trafficking R-HSA-190828 1.920165e-03 2.717 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.962578e-03 2.707 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.138788e-03 2.670 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.149399e-03 2.668 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.227524e-03 2.652 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.348512e-03 2.629 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.382400e-03 2.623 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.348512e-03 2.629 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.486493e-03 2.604 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.500493e-03 2.602 0 0
Signaling by RAS mutants R-HSA-6802949 2.725733e-03 2.565 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.725733e-03 2.565 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.725733e-03 2.565 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.725733e-03 2.565 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.707493e-03 2.567 0 0
Cell-Cell communication R-HSA-1500931 2.863553e-03 2.543 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.023303e-03 2.520 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.071534e-03 2.513 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.044567e-03 2.516 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.089100e-03 2.510 0 0
Signaling by ALK in cancer R-HSA-9700206 3.089100e-03 2.510 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.140691e-03 2.503 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.305825e-03 2.481 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.447630e-03 2.462 0 0
MTOR signalling R-HSA-165159 3.456266e-03 2.461 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.764114e-03 2.424 0 0
Cell junction organization R-HSA-446728 3.538074e-03 2.451 0 0
Membrane Trafficking R-HSA-199991 3.507580e-03 2.455 0 0
Macroautophagy R-HSA-1632852 3.511803e-03 2.454 0 0
Cell Cycle Checkpoints R-HSA-69620 3.663784e-03 2.436 0 0
Mitotic Prophase R-HSA-68875 4.014506e-03 2.396 0 0
RNA Polymerase II Transcription R-HSA-73857 4.151141e-03 2.382 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.157740e-03 2.381 0 0
Apoptosis R-HSA-109581 4.389560e-03 2.358 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.802084e-03 2.319 0 0
Nuclear import of Rev protein R-HSA-180746 4.629590e-03 2.334 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.561144e-03 2.341 0 0
Autophagy R-HSA-9612973 4.590706e-03 2.338 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.543729e-03 2.343 0 0
Activation of BH3-only proteins R-HSA-114452 4.802084e-03 2.319 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.600291e-03 2.337 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.830996e-03 2.316 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.830996e-03 2.316 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.945473e-03 2.306 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.093068e-03 2.293 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.093068e-03 2.293 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.212107e-03 2.283 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.212107e-03 2.283 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.560974e-03 2.255 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.667618e-03 2.247 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.843252e-03 2.233 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.843252e-03 2.233 0 0
Semaphorin interactions R-HSA-373755 6.405433e-03 2.193 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.197758e-03 2.208 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.420953e-03 2.192 0 0
Centrosome maturation R-HSA-380287 6.512768e-03 2.186 0 0
Signal Transduction R-HSA-162582 6.709924e-03 2.173 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.293371e-03 2.137 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.413637e-03 2.130 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.413637e-03 2.130 0 0
mTORC1-mediated signalling R-HSA-166208 7.484238e-03 2.126 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.605067e-03 2.119 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.740918e-03 2.058 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.452699e-03 2.073 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.866871e-03 2.104 0 0
snRNP Assembly R-HSA-191859 8.184016e-03 2.087 0 0
Metabolism of non-coding RNA R-HSA-194441 8.184016e-03 2.087 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.289976e-03 2.081 0 0
DCC mediated attractive signaling R-HSA-418885 8.740918e-03 2.058 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.452699e-03 2.073 0 0
Cilium Assembly R-HSA-5617833 8.718008e-03 2.060 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.740918e-03 2.058 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.740918e-03 2.058 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.270629e-03 2.033 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.316060e-03 2.031 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.005686e-02 1.998 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.039728e-02 1.983 0 0
G2/M Transition R-HSA-69275 1.059299e-02 1.975 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.077433e-02 1.968 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.090921e-02 1.962 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.112554e-02 1.954 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.265563e-02 1.898 0 0
Signaling by EGFR R-HSA-177929 1.191731e-02 1.924 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.126616e-02 1.948 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.126616e-02 1.948 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.233124e-02 1.909 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.212882e-02 1.916 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.172345e-02 1.931 0 0
Signaling by VEGF R-HSA-194138 1.234548e-02 1.908 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.159331e-02 1.936 0 0
PKR-mediated signaling R-HSA-9833482 1.150329e-02 1.939 0 0
Gap junction assembly R-HSA-190861 1.188519e-02 1.925 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.277339e-02 1.894 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.287357e-02 1.890 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.308978e-02 1.883 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.356648e-02 1.868 0 0
Long-term potentiation R-HSA-9620244 1.373926e-02 1.862 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.377594e-02 1.861 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.441471e-02 1.841 0 0
G2/M Checkpoints R-HSA-69481 1.453088e-02 1.838 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.466789e-02 1.834 0 0
FLT3 Signaling R-HSA-9607240 1.466789e-02 1.834 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.526910e-02 1.816 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.561954e-02 1.806 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.639897e-02 1.785 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.639897e-02 1.785 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.661746e-02 1.779 0 0
MAP2K and MAPK activation R-HSA-5674135 1.691409e-02 1.772 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.691409e-02 1.772 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.730802e-02 1.762 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.752040e-02 1.756 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.959919e-02 1.708 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.764009e-02 1.753 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.764009e-02 1.753 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.931588e-02 1.714 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.769579e-02 1.752 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.010579e-02 1.697 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.029177e-02 1.693 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.090958e-02 1.680 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.102086e-02 1.677 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.118537e-02 1.674 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.118537e-02 1.674 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.202559e-02 1.657 0 0
Signaling by SCF-KIT R-HSA-1433557 2.217009e-02 1.654 0 0
HIV Life Cycle R-HSA-162587 2.247885e-02 1.648 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.307208e-02 1.637 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.412348e-02 1.618 0 0
Protein folding R-HSA-391251 2.419217e-02 1.616 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.440023e-02 1.613 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.440023e-02 1.613 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.442668e-02 1.612 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.467532e-02 1.608 0 0
NRAGE signals death through JNK R-HSA-193648 2.467532e-02 1.608 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.503882e-02 1.601 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.722957e-02 1.565 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.007713e-02 1.522 0 0
Deadenylation of mRNA R-HSA-429947 3.007713e-02 1.522 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.167499e-02 1.499 0 0
RAF activation R-HSA-5673000 2.821242e-02 1.550 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.167499e-02 1.499 0 0
Homology Directed Repair R-HSA-5693538 3.158334e-02 1.501 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.821242e-02 1.550 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.721308e-02 1.565 0 0
DNA Repair R-HSA-73894 2.848370e-02 1.545 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.891821e-02 1.539 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.821242e-02 1.550 0 0
MHC class II antigen presentation R-HSA-2132295 2.771151e-02 1.557 0 0
PECAM1 interactions R-HSA-210990 2.790438e-02 1.554 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.239742e-02 1.489 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.250652e-02 1.488 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.250652e-02 1.488 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.281929e-02 1.484 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.281929e-02 1.484 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.281929e-02 1.484 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.281929e-02 1.484 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.281929e-02 1.484 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.332557e-02 1.477 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.332557e-02 1.477 0 0
Adherens junctions interactions R-HSA-418990 3.357880e-02 1.474 0 0
Prolonged ERK activation events R-HSA-169893 3.502837e-02 1.456 0 0
Deubiquitination R-HSA-5688426 3.524914e-02 1.453 0 0
TGFBR3 expression R-HSA-9839394 3.536451e-02 1.451 0 0
HDMs demethylate histones R-HSA-3214842 3.536451e-02 1.451 0 0
Activation of RAC1 R-HSA-428540 3.583933e-02 1.446 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.583933e-02 1.446 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.624478e-02 1.441 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.624478e-02 1.441 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.624478e-02 1.441 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.782486e-02 1.422 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.124609e-02 1.385 0 0
Cell-cell junction organization R-HSA-421270 4.125571e-02 1.385 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.177419e-02 1.379 0 0
Signaling by FGFR in disease R-HSA-1226099 4.180287e-02 1.379 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.203548e-02 1.376 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.454562e-02 1.351 0 0
Formation of annular gap junctions R-HSA-196025 4.454562e-02 1.351 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.503359e-02 1.346 0 0
Repression of WNT target genes R-HSA-4641265 4.503359e-02 1.346 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.503359e-02 1.346 0 0
Pervasive developmental disorders R-HSA-9005895 4.503359e-02 1.346 0 0
Disorders of Nervous System Development R-HSA-9697154 4.503359e-02 1.346 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.617608e-02 1.336 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.389949e-02 1.358 0 0
Nucleotide Excision Repair R-HSA-5696398 4.690224e-02 1.329 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.803961e-02 1.318 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.503359e-02 1.346 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.086718e-02 1.294 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.984037e-02 1.302 0 0
Nuclear RNA decay R-HSA-9930044 4.803961e-02 1.318 0 0
HATs acetylate histones R-HSA-3214847 4.629629e-02 1.334 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.751965e-02 1.323 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.808634e-02 1.318 0 0
Generic Transcription Pathway R-HSA-212436 5.146243e-02 1.289 0 0
Programmed Cell Death R-HSA-5357801 5.232213e-02 1.281 0 0
HIV Infection R-HSA-162906 5.274102e-02 1.278 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.282060e-02 1.277 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.282060e-02 1.277 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.532480e-02 1.257 0 0
Frs2-mediated activation R-HSA-170968 5.551099e-02 1.256 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.762597e-02 1.239 0 0
Gap junction degradation R-HSA-190873 5.762597e-02 1.239 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.762597e-02 1.239 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.762597e-02 1.239 0 0
Unwinding of DNA R-HSA-176974 5.762597e-02 1.239 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.777417e-02 1.238 0 0
ESR-mediated signaling R-HSA-8939211 5.968008e-02 1.224 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.064115e-02 1.217 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.065770e-02 1.217 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.065770e-02 1.217 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.159601e-02 1.210 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.258282e-02 1.204 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.264404e-02 1.203 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.405258e-02 1.193 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.452595e-02 1.190 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.452595e-02 1.190 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.677973e-02 1.175 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.363889e-02 1.078 0 0
mRNA Editing: A to I Conversion R-HSA-75064 8.363889e-02 1.078 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.363889e-02 1.078 0 0
C6 deamination of adenosine R-HSA-75102 8.363889e-02 1.078 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.363889e-02 1.078 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.363889e-02 1.078 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.363889e-02 1.078 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.240347e-02 1.140 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.240347e-02 1.140 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.240347e-02 1.140 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.253236e-02 1.139 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.031635e-02 1.095 0 0
Regulation of signaling by CBL R-HSA-912631 7.114773e-02 1.148 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.261397e-02 1.083 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.196168e-02 1.143 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.212840e-02 1.086 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.737123e-02 1.111 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.075878e-02 1.150 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.729165e-02 1.172 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.405656e-02 1.130 0 0
RNA Polymerase III Transcription R-HSA-74158 7.737123e-02 1.111 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.107018e-02 1.148 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.789782e-02 1.108 0 0
Regulation of CDH11 function R-HSA-9762292 7.253236e-02 1.139 0 0
Trafficking of AMPA receptors R-HSA-399719 8.015370e-02 1.096 0 0
Signal transduction by L1 R-HSA-445144 8.261397e-02 1.083 0 0
Signaling by NOTCH3 R-HSA-9012852 8.067717e-02 1.093 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.203999e-02 1.086 0 0
Intraflagellar transport R-HSA-5620924 7.789782e-02 1.108 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.253236e-02 1.139 0 0
tRNA processing in the nucleus R-HSA-6784531 8.270647e-02 1.082 0 0
Inositol phosphate metabolism R-HSA-1483249 7.501384e-02 1.125 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.478030e-02 1.072 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.610312e-02 1.065 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.610312e-02 1.065 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.795632e-02 1.056 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.970023e-02 1.047 0 0
DNA strand elongation R-HSA-69190 8.989451e-02 1.046 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.989451e-02 1.046 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.307825e-02 1.031 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.307825e-02 1.031 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.307825e-02 1.031 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.460105e-02 1.024 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.460105e-02 1.024 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 9.472494e-02 1.024 0 0
Nef and signal transduction R-HSA-164944 9.472494e-02 1.024 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 9.472494e-02 1.024 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.504320e-02 1.022 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.790923e-02 1.009 0 0
G alpha (12/13) signalling events R-HSA-416482 9.832247e-02 1.007 0 0
Integrin signaling R-HSA-354192 1.002882e-01 0.999 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.002882e-01 0.999 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.002882e-01 0.999 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.002882e-01 0.999 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.008297e-01 0.996 0 0
HSF1-dependent transactivation R-HSA-3371571 1.019353e-01 0.992 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.036938e-01 0.984 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.036938e-01 0.984 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.048004e-01 0.980 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.126774e-01 0.948 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.126774e-01 0.948 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.126774e-01 0.948 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.126774e-01 0.948 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.126774e-01 0.948 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.126774e-01 0.948 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.126774e-01 0.948 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.211289e-01 0.917 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.211289e-01 0.917 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.211289e-01 0.917 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.194692e-01 0.923 0 0
SOS-mediated signalling R-HSA-112412 1.194692e-01 0.923 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.194692e-01 0.923 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.273819e-01 0.895 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.273819e-01 0.895 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.273819e-01 0.895 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.100853e-01 0.958 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.267107e-01 0.897 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.267107e-01 0.897 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.267107e-01 0.897 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.084130e-01 0.965 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.084130e-01 0.965 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.084130e-01 0.965 0 0
Notch-HLH transcription pathway R-HSA-350054 1.226924e-01 0.911 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.113263e-01 0.953 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.304891e-01 0.884 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.052528e-01 0.978 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.184543e-01 0.926 0 0
Translation initiation complex formation R-HSA-72649 1.298762e-01 0.886 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.052836e-01 0.978 0 0
Signaling by ERBB4 R-HSA-1236394 1.210081e-01 0.917 0 0
PTEN Regulation R-HSA-6807070 1.309900e-01 0.883 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.075194e-01 0.969 0 0
Generation of second messenger molecules R-HSA-202433 1.156603e-01 0.937 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.239586e-01 0.907 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.184543e-01 0.926 0 0
Disorders of Developmental Biology R-HSA-9675151 1.100853e-01 0.958 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.127527e-01 0.948 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.194692e-01 0.923 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.226924e-01 0.911 0 0
Co-stimulation by CD28 R-HSA-389356 1.395441e-01 0.855 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.113263e-01 0.953 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.052836e-01 0.978 0 0
Heme signaling R-HSA-9707616 1.398294e-01 0.854 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.273819e-01 0.895 0 0
Syndecan interactions R-HSA-3000170 1.378426e-01 0.861 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.226924e-01 0.911 0 0
Signalling to ERKs R-HSA-187687 1.352812e-01 0.869 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.094173e-01 0.961 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.212368e-01 0.916 0 0
Signaling by ROBO receptors R-HSA-376176 1.237313e-01 0.908 0 0
HDACs deacetylate histones R-HSA-3214815 1.400344e-01 0.854 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.266110e-01 0.898 0 0
Host Interactions of HIV factors R-HSA-162909 1.110969e-01 0.954 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.211289e-01 0.917 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.267107e-01 0.897 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.392813e-01 0.856 0 0
Potential therapeutics for SARS R-HSA-9679191 1.147603e-01 0.940 0 0
Signaling by TGFBR3 R-HSA-9839373 1.184543e-01 0.926 0 0
Signaling by KIT in disease R-HSA-9669938 1.226924e-01 0.911 0 0
Diseases of DNA repair R-HSA-9675135 1.184543e-01 0.926 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.194692e-01 0.923 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.444061e-01 0.840 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.444061e-01 0.840 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.444073e-01 0.840 0 0
GAB1 signalosome R-HSA-180292 1.444073e-01 0.840 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.444073e-01 0.840 0 0
Type I hemidesmosome assembly R-HSA-446107 1.462949e-01 0.835 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.462949e-01 0.835 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.462949e-01 0.835 0 0
HSF1 activation R-HSA-3371511 1.481615e-01 0.829 0 0
FLT3 signaling in disease R-HSA-9682385 1.481615e-01 0.829 0 0
RET signaling R-HSA-8853659 1.481615e-01 0.829 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.485627e-01 0.828 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.486450e-01 0.828 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.486450e-01 0.828 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.486450e-01 0.828 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.486450e-01 0.828 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.486450e-01 0.828 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.500893e-01 0.824 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.506008e-01 0.822 0 0
TNF signaling R-HSA-75893 1.506008e-01 0.822 0 0
DNA Damage Bypass R-HSA-73893 1.507779e-01 0.822 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.507779e-01 0.822 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.538181e-01 0.813 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.538181e-01 0.813 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.545050e-01 0.811 0 0
MAPK family signaling cascades R-HSA-5683057 1.556412e-01 0.808 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.574171e-01 0.803 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.583444e-01 0.800 0 0
EGFR downregulation R-HSA-182971 1.589972e-01 0.799 0 0
Regulation of CDH1 Function R-HSA-9764561 1.615645e-01 0.792 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.618071e-01 0.791 0 0
Regulation of gap junction activity R-HSA-191650 1.618071e-01 0.791 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.618071e-01 0.791 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.618071e-01 0.791 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.618071e-01 0.791 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.618071e-01 0.791 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.618071e-01 0.791 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.618071e-01 0.791 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.630957e-01 0.788 0 0
Rap1 signalling R-HSA-392517 1.630957e-01 0.788 0 0
HCMV Early Events R-HSA-9609690 1.692716e-01 0.771 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.705670e-01 0.768 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.711576e-01 0.767 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.711576e-01 0.767 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.711576e-01 0.767 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.711576e-01 0.767 0 0
G0 and Early G1 R-HSA-1538133 1.742261e-01 0.759 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.742261e-01 0.759 0 0
ARMS-mediated activation R-HSA-170984 1.748520e-01 0.757 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.748520e-01 0.757 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.748520e-01 0.757 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.748520e-01 0.757 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.748520e-01 0.757 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.748520e-01 0.757 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.748520e-01 0.757 0 0
Netrin-1 signaling R-HSA-373752 1.755558e-01 0.756 0 0
Developmental Biology R-HSA-1266738 1.780812e-01 0.749 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.796688e-01 0.746 0 0
Formation of definitive endoderm R-HSA-9823730 1.826888e-01 0.738 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.846328e-01 0.734 0 0
Neurexins and neuroligins R-HSA-6794361 1.870637e-01 0.728 0 0
Myogenesis R-HSA-525793 1.880327e-01 0.726 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.126644e-01 0.672 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.126644e-01 0.672 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.126644e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.126644e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.126644e-01 0.672 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.126644e-01 0.672 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.126644e-01 0.672 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.126644e-01 0.672 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.044799e-01 0.689 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.044799e-01 0.689 0 0
IRS activation R-HSA-74713 2.044799e-01 0.689 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.044799e-01 0.689 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.044799e-01 0.689 0 0
G2 Phase R-HSA-68911 2.044799e-01 0.689 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.044799e-01 0.689 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.481820e-01 0.605 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.481820e-01 0.605 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.481820e-01 0.605 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.047941e-01 0.689 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.047941e-01 0.689 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.047941e-01 0.689 0 0
Erythropoietin activates RAS R-HSA-9027284 1.947603e-01 0.710 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.947603e-01 0.710 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.947603e-01 0.710 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.947603e-01 0.710 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.192897e-01 0.659 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.192897e-01 0.659 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.030939e-01 0.692 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.030939e-01 0.692 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.445812e-01 0.612 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.242140e-01 0.649 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.061540e-01 0.686 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.061540e-01 0.686 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.061540e-01 0.686 0 0
FGFR2 alternative splicing R-HSA-6803529 2.459498e-01 0.609 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.248666e-01 0.648 0 0
HIV elongation arrest and recovery R-HSA-167287 2.248666e-01 0.648 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.248666e-01 0.648 0 0
Striated Muscle Contraction R-HSA-390522 2.064344e-01 0.685 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.233251e-01 0.651 0 0
DAP12 signaling R-HSA-2424491 2.637973e-01 0.579 0 0
Meiotic synapsis R-HSA-1221632 1.999622e-01 0.699 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.522644e-01 0.598 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.009158e-01 0.697 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.486228e-01 0.604 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.047941e-01 0.689 0 0
Meiosis R-HSA-1500620 2.291862e-01 0.640 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.192897e-01 0.659 0 0
Oncogene Induced Senescence R-HSA-2559585 2.406768e-01 0.619 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.061540e-01 0.686 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.291862e-01 0.640 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.704728e-01 0.568 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.044799e-01 0.689 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.044799e-01 0.689 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.481820e-01 0.605 0 0
Cellular Senescence R-HSA-2559583 2.177094e-01 0.662 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.682010e-01 0.572 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.967080e-01 0.706 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.967080e-01 0.706 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.967080e-01 0.706 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.967080e-01 0.706 0 0
Degradation of CDH1 R-HSA-9766229 2.467274e-01 0.608 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.842829e-01 0.546 0 0
Vesicle-mediated transport R-HSA-5653656 1.920654e-01 0.717 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.218582e-01 0.654 0 0
Cellular responses to stress R-HSA-2262752 2.469662e-01 0.607 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.947603e-01 0.710 0 0
Reelin signalling pathway R-HSA-8866376 2.044799e-01 0.689 0 0
Negative regulation of FLT3 R-HSA-9706369 2.192897e-01 0.659 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.242140e-01 0.649 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.679405e-01 0.572 0 0
S Phase R-HSA-69242 2.011358e-01 0.697 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.707200e-01 0.567 0 0
Signaling by NOTCH1 R-HSA-1980143 2.119133e-01 0.674 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.704728e-01 0.568 0 0
Ca-dependent events R-HSA-111996 2.526616e-01 0.597 0 0
Signaling by NTRKs R-HSA-166520 2.011358e-01 0.697 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.291862e-01 0.640 0 0
Protein ubiquitination R-HSA-8852135 2.006134e-01 0.698 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.481820e-01 0.605 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.704728e-01 0.568 0 0
Calmodulin induced events R-HSA-111933 2.584402e-01 0.588 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.765820e-01 0.558 0 0
CaM pathway R-HSA-111997 2.584402e-01 0.588 0 0
Josephin domain DUBs R-HSA-5689877 2.047941e-01 0.689 0 0
Signaling by ALK R-HSA-201556 1.901230e-01 0.721 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.967080e-01 0.706 0 0
Signaling by TGFB family members R-HSA-9006936 2.355876e-01 0.628 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.445812e-01 0.612 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.550153e-01 0.593 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.192897e-01 0.659 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.044799e-01 0.689 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.061540e-01 0.686 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.013897e-01 0.521 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.013897e-01 0.521 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.013897e-01 0.521 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.013897e-01 0.521 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.013897e-01 0.521 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.801211e-01 0.420 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.801211e-01 0.420 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.801211e-01 0.420 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.801211e-01 0.420 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.801211e-01 0.420 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.801211e-01 0.420 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.921402e-01 0.534 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.921402e-01 0.534 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.921402e-01 0.534 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.357421e-01 0.474 0 0
Regulation of PTEN localization R-HSA-8948747 3.357421e-01 0.474 0 0
VLDL clearance R-HSA-8964046 3.357421e-01 0.474 0 0
Disinhibition of SNARE formation R-HSA-114516 3.357421e-01 0.474 0 0
Recycling of eIF2:GDP R-HSA-72731 3.357421e-01 0.474 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.499838e-01 0.347 0 0
MET activates PTPN11 R-HSA-8865999 4.499838e-01 0.347 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.499838e-01 0.347 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.499838e-01 0.347 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.996941e-01 0.523 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.996941e-01 0.523 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.785102e-01 0.422 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.785102e-01 0.422 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.785102e-01 0.422 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.785102e-01 0.422 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.785102e-01 0.422 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.320511e-01 0.479 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.320511e-01 0.479 0 0
Formation of axial mesoderm R-HSA-9796292 3.320511e-01 0.479 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.968068e-01 0.528 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.968068e-01 0.528 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.643510e-01 0.438 0 0
WNT mediated activation of DVL R-HSA-201688 4.200788e-01 0.377 0 0
Calcineurin activates NFAT R-HSA-2025928 4.200788e-01 0.377 0 0
ALK mutants bind TKIs R-HSA-9700645 4.200788e-01 0.377 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.119763e-01 0.291 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.119763e-01 0.291 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.119763e-01 0.291 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.963834e-01 0.402 0 0
Translesion synthesis by REV1 R-HSA-110312 3.963834e-01 0.402 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.370574e-01 0.472 0 0
Lagging Strand Synthesis R-HSA-69186 3.769948e-01 0.424 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.769948e-01 0.424 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.601753e-01 0.337 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.601753e-01 0.337 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.603920e-01 0.443 0 0
Nucleosome assembly R-HSA-774815 3.032380e-01 0.518 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.032380e-01 0.518 0 0
Translesion synthesis by POLI R-HSA-5656121 4.279647e-01 0.369 0 0
Phosphorylation of the APC/C R-HSA-176412 4.279647e-01 0.369 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.279647e-01 0.369 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.325887e-01 0.478 0 0
Attenuation phase R-HSA-3371568 3.325887e-01 0.478 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.325887e-01 0.478 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.837675e-01 0.416 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.837675e-01 0.416 0 0
Dual Incision in GG-NER R-HSA-5696400 3.666973e-01 0.436 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.144370e-01 0.502 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.940803e-01 0.532 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.708032e-01 0.431 0 0
HIV Transcription Initiation R-HSA-167161 3.708032e-01 0.431 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.708032e-01 0.431 0 0
Signaling by Erythropoietin R-HSA-9006335 4.071005e-01 0.390 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.071005e-01 0.390 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.301324e-01 0.366 0 0
Translesion synthesis by POLK R-HSA-5655862 4.589376e-01 0.338 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.986036e-01 0.302 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.986036e-01 0.302 0 0
Signaling by APC mutants R-HSA-4839744 4.986036e-01 0.302 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.986036e-01 0.302 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.986036e-01 0.302 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.986036e-01 0.302 0 0
NrCAM interactions R-HSA-447038 5.669848e-01 0.246 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.669848e-01 0.246 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.669848e-01 0.246 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.669848e-01 0.246 0 0
RUNX2 regulates bone development R-HSA-8941326 4.086824e-01 0.389 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.303128e-01 0.366 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.562659e-01 0.341 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.092484e-01 0.388 0 0
Dual incision in TC-NER R-HSA-6782135 3.920471e-01 0.407 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.891690e-01 0.311 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.352304e-01 0.271 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.352304e-01 0.271 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.352304e-01 0.271 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.352304e-01 0.271 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.352304e-01 0.271 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.352304e-01 0.271 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.352304e-01 0.271 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.475547e-01 0.349 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.883724e-01 0.411 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.185489e-01 0.285 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.665489e-01 0.331 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.072050e-01 0.295 0 0
Tight junction interactions R-HSA-420029 5.072050e-01 0.295 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.302843e-01 0.366 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.914318e-01 0.309 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.662306e-01 0.331 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.469885e-01 0.262 0 0
Polymerase switching R-HSA-69091 5.699737e-01 0.244 0 0
Leading Strand Synthesis R-HSA-69109 5.699737e-01 0.244 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.699737e-01 0.244 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.699737e-01 0.244 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.699737e-01 0.244 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.699737e-01 0.244 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.699737e-01 0.244 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.558870e-01 0.255 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.558870e-01 0.255 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.633824e-01 0.249 0 0
Transcription of the HIV genome R-HSA-167172 3.039093e-01 0.517 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.883724e-01 0.411 0 0
Downstream signal transduction R-HSA-186763 4.533315e-01 0.344 0 0
HIV Transcription Elongation R-HSA-167169 3.325887e-01 0.478 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.516430e-01 0.454 0 0
Chromosome Maintenance R-HSA-73886 3.532812e-01 0.452 0 0
MET promotes cell motility R-HSA-8875878 2.949984e-01 0.530 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.352304e-01 0.271 0 0
Formation of apoptosome R-HSA-111458 4.601753e-01 0.337 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.325887e-01 0.478 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.769948e-01 0.424 0 0
Activation of the pre-replicative complex R-HSA-68962 4.303128e-01 0.366 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.909150e-01 0.309 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.325887e-01 0.478 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.502061e-01 0.456 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.032380e-01 0.518 0 0
DNA Double Strand Break Response R-HSA-5693606 2.896690e-01 0.538 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.144370e-01 0.502 0 0
Signaling by FGFR1 R-HSA-5654736 4.975105e-01 0.303 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.314004e-01 0.275 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.589376e-01 0.338 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.469885e-01 0.262 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.357421e-01 0.474 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.357421e-01 0.474 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.502061e-01 0.456 0 0
G-protein beta:gamma signalling R-HSA-397795 3.249235e-01 0.488 0 0
PI3K/AKT activation R-HSA-198203 4.601753e-01 0.337 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.136903e-01 0.503 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.986036e-01 0.302 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.086824e-01 0.389 0 0
Polo-like kinase mediated events R-HSA-156711 5.185489e-01 0.285 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.968068e-01 0.528 0 0
IRS-mediated signalling R-HSA-112399 3.753592e-01 0.426 0 0
FOXO-mediated transcription R-HSA-9614085 4.434674e-01 0.353 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.119763e-01 0.291 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.325887e-01 0.478 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.589376e-01 0.338 0 0
NF-kB is activated and signals survival R-HSA-209560 5.352304e-01 0.271 0 0
Translesion Synthesis by POLH R-HSA-110320 5.469885e-01 0.262 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.699737e-01 0.244 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.731769e-01 0.428 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.352304e-01 0.271 0 0
Integration of provirus R-HSA-162592 5.352304e-01 0.271 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.699737e-01 0.244 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.056871e-01 0.392 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.881535e-01 0.411 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 3.138519e-01 0.503 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.036746e-01 0.394 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.710280e-01 0.327 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.423643e-01 0.354 0 0
Signaling by FGFR R-HSA-190236 5.405933e-01 0.267 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.234322e-01 0.490 0 0
mRNA Editing R-HSA-75072 4.200788e-01 0.377 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.249235e-01 0.488 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.589376e-01 0.338 0 0
Formation of the posterior neural plate R-HSA-9832991 4.986036e-01 0.302 0 0
Activation of AKT2 R-HSA-165158 5.669848e-01 0.246 0 0
PI3K Cascade R-HSA-109704 3.913591e-01 0.407 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.891690e-01 0.311 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.891690e-01 0.311 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.475547e-01 0.349 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.185489e-01 0.285 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.699737e-01 0.244 0 0
Mitophagy R-HSA-5205647 3.666973e-01 0.436 0 0
Signaling by NOTCH4 R-HSA-9013694 5.173939e-01 0.286 0 0
IGF1R signaling cascade R-HSA-2428924 3.608595e-01 0.443 0 0
rRNA processing R-HSA-72312 3.896579e-01 0.409 0 0
TCR signaling R-HSA-202403 3.892426e-01 0.410 0 0
Signaling by MET R-HSA-6806834 3.634536e-01 0.440 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.669848e-01 0.246 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.270303e-01 0.370 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.072050e-01 0.295 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.603920e-01 0.443 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.490888e-01 0.348 0 0
Nephrin family interactions R-HSA-373753 3.502061e-01 0.456 0 0
Signaling by FGFR2 R-HSA-5654738 4.818813e-01 0.317 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.633824e-01 0.249 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.205858e-01 0.284 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.200788e-01 0.377 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.119763e-01 0.291 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.370574e-01 0.472 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.279647e-01 0.369 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.476043e-01 0.262 0 0
G-protein mediated events R-HSA-112040 5.401206e-01 0.268 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.765431e-01 0.424 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.589376e-01 0.338 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.890710e-01 0.539 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.352304e-01 0.271 0 0
Insulin receptor signalling cascade R-HSA-74751 4.917573e-01 0.308 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.200788e-01 0.377 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.922869e-01 0.406 0 0
Signaling by NOTCH R-HSA-157118 5.303083e-01 0.275 0 0
HCMV Infection R-HSA-9609646 4.727828e-01 0.325 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.452626e-01 0.462 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.963834e-01 0.402 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.469885e-01 0.262 0 0
Rab regulation of trafficking R-HSA-9007101 4.994842e-01 0.301 0 0
p75NTR signals via NF-kB R-HSA-193639 3.963834e-01 0.402 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.314004e-01 0.275 0 0
Ub-specific processing proteases R-HSA-5689880 4.408672e-01 0.356 0 0
Cellular responses to stimuli R-HSA-8953897 4.215616e-01 0.375 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.013897e-01 0.521 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.801211e-01 0.420 0 0
MET interacts with TNS proteins R-HSA-8875513 4.499838e-01 0.347 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.785102e-01 0.422 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.234322e-01 0.490 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.138519e-01 0.503 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.279647e-01 0.369 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 2.992625e-01 0.524 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.589376e-01 0.338 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.669848e-01 0.246 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.352304e-01 0.271 0 0
Signaling by AXIN mutants R-HSA-4839735 5.352304e-01 0.271 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.352304e-01 0.271 0 0
Metalloprotease DUBs R-HSA-5689901 5.318595e-01 0.274 0 0
MET activates RAS signaling R-HSA-8851805 5.699737e-01 0.244 0 0
Signaling by NOTCH2 R-HSA-1980145 5.422191e-01 0.266 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.342095e-01 0.272 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.325829e-01 0.274 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.670375e-01 0.331 0 0
Gene Silencing by RNA R-HSA-211000 3.528352e-01 0.452 0 0
Ion transport by P-type ATPases R-HSA-936837 4.917573e-01 0.308 0 0
PLC beta mediated events R-HSA-112043 4.421649e-01 0.354 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.643510e-01 0.438 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.486408e-01 0.261 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.649673e-01 0.333 0 0
The NLRP3 inflammasome R-HSA-844456 5.469885e-01 0.262 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.699737e-01 0.244 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.769948e-01 0.424 0 0
NGF-stimulated transcription R-HSA-9031628 5.040245e-01 0.298 0 0
Signal attenuation R-HSA-74749 4.601753e-01 0.337 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.249235e-01 0.488 0 0
RMTs methylate histone arginines R-HSA-3214858 2.861076e-01 0.543 0 0
Gastrulation R-HSA-9758941 5.269599e-01 0.278 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.785102e-01 0.422 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.119763e-01 0.291 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.669848e-01 0.246 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.321310e-01 0.479 0 0
Signaling by LTK R-HSA-9842663 5.699737e-01 0.244 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.603920e-01 0.443 0 0
Signaling by PTK6 R-HSA-8848021 3.452626e-01 0.462 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.452626e-01 0.462 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.320511e-01 0.479 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.891690e-01 0.311 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.318595e-01 0.274 0 0
DAG and IP3 signaling R-HSA-1489509 3.032380e-01 0.518 0 0
Mismatch Repair R-HSA-5358508 2.968068e-01 0.528 0 0
Ion homeostasis R-HSA-5578775 4.975105e-01 0.303 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.381123e-01 0.471 0 0
Interferon Signaling R-HSA-913531 3.662124e-01 0.436 0 0
Hedgehog 'off' state R-HSA-5610787 4.566332e-01 0.340 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.013897e-01 0.521 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.921402e-01 0.534 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.785102e-01 0.422 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.200788e-01 0.377 0 0
NADE modulates death signalling R-HSA-205025 5.119763e-01 0.291 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.119763e-01 0.291 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.769948e-01 0.424 0 0
2-LTR circle formation R-HSA-164843 4.601753e-01 0.337 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.301324e-01 0.366 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.589376e-01 0.338 0 0
Transport of RCbl within the body R-HSA-9758890 4.986036e-01 0.302 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.669848e-01 0.246 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.352304e-01 0.271 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.912847e-01 0.536 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.115695e-01 0.291 0 0
Regulation of beta-cell development R-HSA-186712 5.486408e-01 0.261 0 0
Neurofascin interactions R-HSA-447043 2.921402e-01 0.534 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.249235e-01 0.488 0 0
Maturation of nucleoprotein R-HSA-9694631 5.469885e-01 0.262 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.405859e-01 0.267 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.603920e-01 0.443 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.510089e-01 0.346 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.205858e-01 0.284 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.119763e-01 0.291 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.601753e-01 0.337 0 0
Bicarbonate transporters R-HSA-425381 4.986036e-01 0.302 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.669848e-01 0.246 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.301324e-01 0.366 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.301324e-01 0.366 0 0
NGF processing R-HSA-167060 4.499838e-01 0.347 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.499838e-01 0.347 0 0
Signal regulatory protein family interactions R-HSA-391160 3.643510e-01 0.438 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.200788e-01 0.377 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.200788e-01 0.377 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.352304e-01 0.271 0 0
SARS-CoV Infections R-HSA-9679506 3.664297e-01 0.436 0 0
Interleukin-15 signaling R-HSA-8983432 5.699737e-01 0.244 0 0
Glycolysis R-HSA-70171 3.523526e-01 0.453 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.279647e-01 0.369 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.270303e-01 0.370 0 0
Specification of primordial germ cells R-HSA-9827857 4.891690e-01 0.311 0 0
OAS antiviral response R-HSA-8983711 5.699737e-01 0.244 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.441167e-01 0.264 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.699737e-01 0.244 0 0
Signaling by Leptin R-HSA-2586552 4.601753e-01 0.337 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.801211e-01 0.420 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.699737e-01 0.244 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.669848e-01 0.246 0 0
Signaling by FGFR4 R-HSA-5654743 5.699981e-01 0.244 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.707779e-01 0.244 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.744178e-01 0.241 0 0
Negative regulation of MET activity R-HSA-6807004 5.744178e-01 0.241 0 0
Signaling by NODAL R-HSA-1181150 5.744178e-01 0.241 0 0
Reproduction R-HSA-1474165 5.758656e-01 0.240 0 0
RNA Polymerase I Transcription R-HSA-73864 5.770754e-01 0.239 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.792369e-01 0.237 0 0
GPVI-mediated activation cascade R-HSA-114604 5.840378e-01 0.234 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.866575e-01 0.232 0 0
Adipogenesis R-HSA-9843745 5.870023e-01 0.231 0 0
G1 Phase R-HSA-69236 5.887019e-01 0.230 0 0
Cyclin D associated events in G1 R-HSA-69231 5.887019e-01 0.230 0 0
DAP12 interactions R-HSA-2172127 5.887019e-01 0.230 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.897751e-01 0.229 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.920993e-01 0.228 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.931723e-01 0.227 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.931967e-01 0.227 0 0
Signaling by PDGF R-HSA-186797 5.975193e-01 0.224 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.975193e-01 0.224 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.981412e-01 0.223 0 0
ERK/MAPK targets R-HSA-198753 6.007845e-01 0.221 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.007845e-01 0.221 0 0
Basigin interactions R-HSA-210991 6.007845e-01 0.221 0 0
Glucose metabolism R-HSA-70326 6.008688e-01 0.221 0 0
mRNA Capping R-HSA-72086 6.018674e-01 0.220 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.018674e-01 0.220 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.018674e-01 0.220 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.018674e-01 0.220 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.027928e-01 0.220 0 0
Maturation of nucleoprotein R-HSA-9683610 6.027928e-01 0.220 0 0
Processing of SMDT1 R-HSA-8949664 6.027928e-01 0.220 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.027928e-01 0.220 0 0
Signaling by FGFR3 R-HSA-5654741 6.069733e-01 0.217 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.157958e-01 0.211 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.157958e-01 0.211 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.157958e-01 0.211 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.157958e-01 0.211 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.157958e-01 0.211 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.157958e-01 0.211 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.157958e-01 0.211 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.157958e-01 0.211 0 0
PKB-mediated events R-HSA-109703 6.157958e-01 0.211 0 0
PDE3B signalling R-HSA-165160 6.157958e-01 0.211 0 0
Synthesis of PS R-HSA-1483101 6.157958e-01 0.211 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.157958e-01 0.211 0 0
Relaxin receptors R-HSA-444821 6.157958e-01 0.211 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.157958e-01 0.211 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.164246e-01 0.210 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.164246e-01 0.210 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.207570e-01 0.207 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.237453e-01 0.205 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.259260e-01 0.203 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.260516e-01 0.203 0 0
Attachment and Entry R-HSA-9694614 6.260516e-01 0.203 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.260516e-01 0.203 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.260516e-01 0.203 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.308862e-01 0.200 0 0
Removal of the Flap Intermediate R-HSA-69166 6.336799e-01 0.198 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.336799e-01 0.198 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.336799e-01 0.198 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.436184e-01 0.191 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.448452e-01 0.191 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.448452e-01 0.191 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.448452e-01 0.191 0 0
Transmission across Chemical Synapses R-HSA-112315 6.456668e-01 0.190 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.460470e-01 0.190 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.469654e-01 0.189 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.501960e-01 0.187 0 0
LDL clearance R-HSA-8964038 6.501960e-01 0.187 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.547694e-01 0.184 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.591072e-01 0.181 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.591072e-01 0.181 0 0
VLDL assembly R-HSA-8866423 6.591072e-01 0.181 0 0
Signaling by LTK in cancer R-HSA-9842640 6.591072e-01 0.181 0 0
Chylomicron clearance R-HSA-8964026 6.591072e-01 0.181 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.591072e-01 0.181 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.591072e-01 0.181 0 0
STAT5 Activation R-HSA-9645135 6.591072e-01 0.181 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 6.591072e-01 0.181 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.591072e-01 0.181 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.591072e-01 0.181 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.591072e-01 0.181 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.591072e-01 0.181 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.591072e-01 0.181 0 0
Leukotriene receptors R-HSA-391906 6.591072e-01 0.181 0 0
CREB3 factors activate genes R-HSA-8874211 6.591072e-01 0.181 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.591072e-01 0.181 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.610052e-01 0.180 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.610052e-01 0.180 0 0
Diseases of Immune System R-HSA-5260271 6.610052e-01 0.180 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.610052e-01 0.180 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.626535e-01 0.179 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.626535e-01 0.179 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.626535e-01 0.179 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.626535e-01 0.179 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.626535e-01 0.179 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.626535e-01 0.179 0 0
p38MAPK events R-HSA-171007 6.626535e-01 0.179 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.626535e-01 0.179 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.626535e-01 0.179 0 0
Biotin transport and metabolism R-HSA-196780 6.626535e-01 0.179 0 0
Protein methylation R-HSA-8876725 6.626535e-01 0.179 0 0
Formation of the anterior neural plate R-HSA-9823739 6.626535e-01 0.179 0 0
DNA Damage Reversal R-HSA-73942 6.626535e-01 0.179 0 0
Synthesis of DNA R-HSA-69239 6.641665e-01 0.178 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.651487e-01 0.177 0 0
Signaling by Hedgehog R-HSA-5358351 6.712892e-01 0.173 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.726147e-01 0.172 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.732062e-01 0.172 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.732062e-01 0.172 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.732062e-01 0.172 0 0
Carnitine shuttle R-HSA-200425 6.732062e-01 0.172 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.732062e-01 0.172 0 0
Growth hormone receptor signaling R-HSA-982772 6.732062e-01 0.172 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.754671e-01 0.170 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.754671e-01 0.170 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.819452e-01 0.166 0 0
Cardiogenesis R-HSA-9733709 6.846442e-01 0.165 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.853298e-01 0.164 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.865605e-01 0.163 0 0
Extension of Telomeres R-HSA-180786 6.882802e-01 0.162 0 0
Regulation of BACH1 activity R-HSA-9708530 6.897526e-01 0.161 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.897526e-01 0.161 0 0
Killing mechanisms R-HSA-9664420 6.897526e-01 0.161 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.897526e-01 0.161 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.897526e-01 0.161 0 0
Differentiation of T cells R-HSA-9945266 6.897526e-01 0.161 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.908269e-01 0.161 0 0
Parasite infection R-HSA-9664407 6.908269e-01 0.161 0 0
Leishmania phagocytosis R-HSA-9664417 6.908269e-01 0.161 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.911708e-01 0.160 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.950814e-01 0.158 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.950814e-01 0.158 0 0
Neurodegenerative Diseases R-HSA-8863678 6.950814e-01 0.158 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.950814e-01 0.158 0 0
Intra-Golgi traffic R-HSA-6811438 6.958282e-01 0.157 0 0
PI Metabolism R-HSA-1483255 6.971474e-01 0.157 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.975383e-01 0.156 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.975383e-01 0.156 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.975383e-01 0.156 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.975383e-01 0.156 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.975383e-01 0.156 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.975383e-01 0.156 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.975383e-01 0.156 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.975383e-01 0.156 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.975383e-01 0.156 0 0
PTK6 Expression R-HSA-8849473 6.975383e-01 0.156 0 0
LDL remodeling R-HSA-8964041 6.975383e-01 0.156 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.975383e-01 0.156 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.975383e-01 0.156 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.975383e-01 0.156 0 0
Netrin mediated repulsion signals R-HSA-418886 6.975383e-01 0.156 0 0
CHL1 interactions R-HSA-447041 6.975383e-01 0.156 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.975383e-01 0.156 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.001281e-01 0.155 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.033257e-01 0.153 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.086640e-01 0.150 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.133117e-01 0.147 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 7.150314e-01 0.146 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 7.150314e-01 0.146 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.150314e-01 0.146 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.150314e-01 0.146 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.150314e-01 0.146 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.158298e-01 0.145 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.158298e-01 0.145 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.158298e-01 0.145 0 0
Interleukin-7 signaling R-HSA-1266695 7.158298e-01 0.145 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.158926e-01 0.145 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.165744e-01 0.145 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.211928e-01 0.142 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.212797e-01 0.142 0 0
Orc1 removal from chromatin R-HSA-68949 7.212797e-01 0.142 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.212797e-01 0.142 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.212797e-01 0.142 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.281080e-01 0.138 0 0
TBC/RABGAPs R-HSA-8854214 7.281080e-01 0.138 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.281080e-01 0.138 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.300521e-01 0.137 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.316389e-01 0.136 0 0
phospho-PLA2 pathway R-HSA-111995 7.316389e-01 0.136 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.316389e-01 0.136 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.316389e-01 0.136 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.316389e-01 0.136 0 0
MET receptor recycling R-HSA-8875656 7.316389e-01 0.136 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.316389e-01 0.136 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.316389e-01 0.136 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.316389e-01 0.136 0 0
Regulation by c-FLIP R-HSA-3371378 7.316389e-01 0.136 0 0
Activation of RAS in B cells R-HSA-1169092 7.316389e-01 0.136 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.316389e-01 0.136 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.316389e-01 0.136 0 0
Dimerization of procaspase-8 R-HSA-69416 7.316389e-01 0.136 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.316389e-01 0.136 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.316389e-01 0.136 0 0
Sodium/Proton exchangers R-HSA-425986 7.316389e-01 0.136 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.316389e-01 0.136 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.351246e-01 0.134 0 0
MET activates PTK2 signaling R-HSA-8874081 7.354668e-01 0.133 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.354668e-01 0.133 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.354668e-01 0.133 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.355448e-01 0.133 0 0
Influenza Infection R-HSA-168255 7.376751e-01 0.132 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.385120e-01 0.132 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.385559e-01 0.132 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.385559e-01 0.132 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.385559e-01 0.132 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.397431e-01 0.131 0 0
Base Excision Repair R-HSA-73884 7.436681e-01 0.129 0 0
Ca2+ pathway R-HSA-4086398 7.505245e-01 0.125 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.540144e-01 0.123 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.540144e-01 0.123 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.544051e-01 0.122 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.545042e-01 0.122 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.577873e-01 0.120 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.578382e-01 0.120 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.578382e-01 0.120 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.604003e-01 0.119 0 0
Platelet sensitization by LDL R-HSA-432142 7.604003e-01 0.119 0 0
Apoptotic factor-mediated response R-HSA-111471 7.604003e-01 0.119 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.604003e-01 0.119 0 0
Co-inhibition by PD-1 R-HSA-389948 7.608510e-01 0.119 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.618966e-01 0.118 0 0
CASP8 activity is inhibited R-HSA-5218900 7.618966e-01 0.118 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.618966e-01 0.118 0 0
Lipophagy R-HSA-9613354 7.618966e-01 0.118 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.618966e-01 0.118 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.618966e-01 0.118 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.618966e-01 0.118 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.618966e-01 0.118 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.618966e-01 0.118 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.618966e-01 0.118 0 0
Interleukin-1 processing R-HSA-448706 7.618966e-01 0.118 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.618966e-01 0.118 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.618966e-01 0.118 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.624958e-01 0.118 0 0
G alpha (z) signalling events R-HSA-418597 7.624958e-01 0.118 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.699687e-01 0.114 0 0
Degradation of DVL R-HSA-4641258 7.699687e-01 0.114 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.714997e-01 0.113 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.714997e-01 0.113 0 0
Inflammasomes R-HSA-622312 7.714997e-01 0.113 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.717578e-01 0.113 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.717578e-01 0.113 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.717578e-01 0.113 0 0
Signaling by Insulin receptor R-HSA-74752 7.749377e-01 0.111 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.751872e-01 0.111 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.751872e-01 0.111 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.790971e-01 0.108 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.806443e-01 0.108 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.806443e-01 0.108 0 0
Other interleukin signaling R-HSA-449836 7.806443e-01 0.108 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.806443e-01 0.108 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.811294e-01 0.107 0 0
UCH proteinases R-HSA-5689603 7.842113e-01 0.106 0 0
Interleukin-12 signaling R-HSA-9020591 7.842113e-01 0.106 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.850576e-01 0.105 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.871502e-01 0.104 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.871502e-01 0.104 0 0
Late endosomal microautophagy R-HSA-9615710 7.879542e-01 0.103 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.879542e-01 0.103 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.879542e-01 0.103 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.887443e-01 0.103 0 0
Binding and entry of HIV virion R-HSA-173107 7.887443e-01 0.103 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.887443e-01 0.103 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.887443e-01 0.103 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.887443e-01 0.103 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.887443e-01 0.103 0 0
Pexophagy R-HSA-9664873 7.887443e-01 0.103 0 0
Stabilization of p53 R-HSA-69541 7.985898e-01 0.098 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.985898e-01 0.098 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.985898e-01 0.098 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.985898e-01 0.098 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.989420e-01 0.097 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.990287e-01 0.097 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.993710e-01 0.097 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.993710e-01 0.097 0 0
Protein hydroxylation R-HSA-9629569 7.993710e-01 0.097 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.993710e-01 0.097 0 0
Cellular response to chemical stress R-HSA-9711123 7.996041e-01 0.097 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.034123e-01 0.095 0 0
PCP/CE pathway R-HSA-4086400 8.047322e-01 0.094 0 0
Opioid Signalling R-HSA-111885 8.079241e-01 0.093 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.079241e-01 0.093 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.098411e-01 0.092 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.115605e-01 0.091 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.117838e-01 0.091 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.117838e-01 0.091 0 0
Interleukin-2 family signaling R-HSA-451927 8.117838e-01 0.091 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.124656e-01 0.090 0 0
Chylomicron assembly R-HSA-8963888 8.125661e-01 0.090 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.125661e-01 0.090 0 0
vRNA Synthesis R-HSA-192814 8.125661e-01 0.090 0 0
vRNP Assembly R-HSA-192905 8.125661e-01 0.090 0 0
Synthesis of PI R-HSA-1483226 8.125661e-01 0.090 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.125661e-01 0.090 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.125661e-01 0.090 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.125661e-01 0.090 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.125661e-01 0.090 0 0
Interleukin-2 signaling R-HSA-9020558 8.125661e-01 0.090 0 0
Sensory processing of sound R-HSA-9659379 8.144231e-01 0.089 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.166651e-01 0.088 0 0
Signalling to RAS R-HSA-167044 8.166651e-01 0.088 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.166651e-01 0.088 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.179114e-01 0.087 0 0
Budding and maturation of HIV virion R-HSA-162588 8.179114e-01 0.087 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.203904e-01 0.086 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.218454e-01 0.085 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.218454e-01 0.085 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.242617e-01 0.084 0 0
Telomere Maintenance R-HSA-157579 8.290965e-01 0.081 0 0
MAP kinase activation R-HSA-450294 8.310595e-01 0.080 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.314640e-01 0.080 0 0
Meiotic recombination R-HSA-912446 8.322910e-01 0.080 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.322910e-01 0.080 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.322910e-01 0.080 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.326116e-01 0.080 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.326116e-01 0.080 0 0
Assembly Of The HIV Virion R-HSA-175474 8.326116e-01 0.080 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.326116e-01 0.080 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.326366e-01 0.080 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.337030e-01 0.079 0 0
DS-GAG biosynthesis R-HSA-2022923 8.337030e-01 0.079 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.337030e-01 0.079 0 0
ERKs are inactivated R-HSA-202670 8.337030e-01 0.079 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.337030e-01 0.079 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.337030e-01 0.079 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.337030e-01 0.079 0 0
Sodium/Calcium exchangers R-HSA-425561 8.337030e-01 0.079 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.337030e-01 0.079 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.343132e-01 0.079 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.360466e-01 0.078 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.360466e-01 0.078 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.366245e-01 0.077 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.370674e-01 0.077 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.370674e-01 0.077 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.370674e-01 0.077 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.405040e-01 0.075 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.407816e-01 0.075 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.426786e-01 0.074 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.441894e-01 0.074 0 0
Adaptive Immune System R-HSA-1280218 8.445553e-01 0.073 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.471627e-01 0.072 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.472943e-01 0.072 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.472943e-01 0.072 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.472943e-01 0.072 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.472943e-01 0.072 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.500458e-01 0.071 0 0
IRE1alpha activates chaperones R-HSA-381070 8.505694e-01 0.070 0 0
G1/S Transition R-HSA-69206 8.522821e-01 0.069 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.524573e-01 0.069 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.524573e-01 0.069 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.524573e-01 0.069 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.524573e-01 0.069 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.524573e-01 0.069 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.524573e-01 0.069 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.524573e-01 0.069 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.524573e-01 0.069 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.524573e-01 0.069 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.525299e-01 0.069 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.525299e-01 0.069 0 0
Smooth Muscle Contraction R-HSA-445355 8.525299e-01 0.069 0 0
Neuronal System R-HSA-112316 8.554509e-01 0.068 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.574155e-01 0.067 0 0
Signaling by WNT R-HSA-195721 8.582000e-01 0.066 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.607955e-01 0.065 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.607955e-01 0.065 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.607955e-01 0.065 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.618624e-01 0.065 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.652396e-01 0.063 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.655257e-01 0.063 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.671117e-01 0.062 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.671117e-01 0.062 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.671117e-01 0.062 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.671117e-01 0.062 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.671117e-01 0.062 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.671117e-01 0.062 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.671117e-01 0.062 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.689675e-01 0.061 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.689675e-01 0.061 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.690976e-01 0.061 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.690976e-01 0.061 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.690976e-01 0.061 0 0
Chylomicron remodeling R-HSA-8963901 8.690976e-01 0.061 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.690976e-01 0.061 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.690976e-01 0.061 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.690976e-01 0.061 0 0
Interleukin-6 signaling R-HSA-1059683 8.690976e-01 0.061 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.731948e-01 0.059 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.731948e-01 0.059 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.731948e-01 0.059 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.767513e-01 0.057 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.767513e-01 0.057 0 0
PPARA activates gene expression R-HSA-1989781 8.770601e-01 0.057 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.774171e-01 0.057 0 0
Regulation of Apoptosis R-HSA-169911 8.774171e-01 0.057 0 0
PERK regulates gene expression R-HSA-381042 8.774171e-01 0.057 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.838620e-01 0.054 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.838620e-01 0.054 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.838620e-01 0.054 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.838620e-01 0.054 0 0
Hydrolysis of LPC R-HSA-1483115 8.838620e-01 0.054 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.838620e-01 0.054 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.838620e-01 0.054 0 0
Zinc transporters R-HSA-435354 8.838620e-01 0.054 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.845690e-01 0.053 0 0
Laminin interactions R-HSA-3000157 8.845690e-01 0.053 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.850235e-01 0.053 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.850235e-01 0.053 0 0
Interleukin-12 family signaling R-HSA-447115 8.857041e-01 0.053 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.863049e-01 0.052 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.863049e-01 0.052 0 0
G1/S-Specific Transcription R-HSA-69205 8.870062e-01 0.052 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.870062e-01 0.052 0 0
Glycosphingolipid transport R-HSA-9845576 8.870062e-01 0.052 0 0
Viral Infection Pathways R-HSA-9824446 8.893923e-01 0.051 0 0
Synthesis of PC R-HSA-1483191 8.936028e-01 0.049 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.943667e-01 0.048 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.949916e-01 0.048 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.949916e-01 0.048 0 0
Sphingolipid catabolism R-HSA-9845614 8.949916e-01 0.048 0 0
Signaling by Interleukins R-HSA-449147 8.955728e-01 0.048 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.959189e-01 0.048 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.969619e-01 0.047 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.969619e-01 0.047 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.969619e-01 0.047 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.969619e-01 0.047 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.969619e-01 0.047 0 0
Other semaphorin interactions R-HSA-416700 8.969619e-01 0.047 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.969619e-01 0.047 0 0
Circadian clock R-HSA-9909396 8.974883e-01 0.047 0 0
Gluconeogenesis R-HSA-70263 9.012441e-01 0.045 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.022467e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.027608e-01 0.044 0 0
Interleukin-17 signaling R-HSA-448424 9.031829e-01 0.044 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.041940e-01 0.044 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.041940e-01 0.044 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.045323e-01 0.044 0 0
Triglyceride biosynthesis R-HSA-75109 9.045323e-01 0.044 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.045323e-01 0.044 0 0
Synthesis of PE R-HSA-1483213 9.045323e-01 0.044 0 0
tRNA processing R-HSA-72306 9.062406e-01 0.043 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.067937e-01 0.042 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.083964e-01 0.042 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.083964e-01 0.042 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.085849e-01 0.042 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.085849e-01 0.042 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.085849e-01 0.042 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.085849e-01 0.042 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.085849e-01 0.042 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.085849e-01 0.042 0 0
Attachment and Entry R-HSA-9678110 9.085849e-01 0.042 0 0
Virus Assembly and Release R-HSA-168268 9.085849e-01 0.042 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.092679e-01 0.041 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.092679e-01 0.041 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.116615e-01 0.040 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.116615e-01 0.040 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.118694e-01 0.040 0 0
RAS processing R-HSA-9648002 9.118694e-01 0.040 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.118694e-01 0.040 0 0
Telomere Extension By Telomerase R-HSA-171319 9.132576e-01 0.039 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.132576e-01 0.039 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.132576e-01 0.039 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.132576e-01 0.039 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.188974e-01 0.037 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.188974e-01 0.037 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.188974e-01 0.037 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.188974e-01 0.037 0 0
Fibronectin matrix formation R-HSA-1566977 9.188974e-01 0.037 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.188974e-01 0.037 0 0
Synthesis of PG R-HSA-1483148 9.188974e-01 0.037 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.188974e-01 0.037 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.188974e-01 0.037 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.200373e-01 0.036 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.212300e-01 0.036 0 0
DNA methylation R-HSA-5334118 9.212300e-01 0.036 0 0
DARPP-32 events R-HSA-180024 9.212300e-01 0.036 0 0
Platelet calcium homeostasis R-HSA-418360 9.212300e-01 0.036 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.233817e-01 0.035 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.255658e-01 0.034 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.255658e-01 0.034 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.280471e-01 0.032 0 0
Glycogen storage diseases R-HSA-3229121 9.280471e-01 0.032 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.280471e-01 0.032 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.280471e-01 0.032 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.280471e-01 0.032 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.285081e-01 0.032 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.285081e-01 0.032 0 0
Interleukin-37 signaling R-HSA-9008059 9.285081e-01 0.032 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.290389e-01 0.032 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.306076e-01 0.031 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.306737e-01 0.031 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.316556e-01 0.031 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.316556e-01 0.031 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.316556e-01 0.031 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.326058e-01 0.030 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.351473e-01 0.029 0 0
Cargo concentration in the ER R-HSA-5694530 9.351473e-01 0.029 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.361650e-01 0.029 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.361650e-01 0.029 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.361650e-01 0.029 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.361650e-01 0.029 0 0
PKA activation in glucagon signalling R-HSA-164378 9.361650e-01 0.029 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.361650e-01 0.029 0 0
PKA activation R-HSA-163615 9.361650e-01 0.029 0 0
Tie2 Signaling R-HSA-210993 9.361650e-01 0.029 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.366094e-01 0.028 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.392457e-01 0.027 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.400639e-01 0.027 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.403979e-01 0.027 0 0
Signaling by WNT in cancer R-HSA-4791275 9.411989e-01 0.026 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.411989e-01 0.026 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.430675e-01 0.025 0 0
Integrin cell surface interactions R-HSA-216083 9.432786e-01 0.025 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.433674e-01 0.025 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.433674e-01 0.025 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.433674e-01 0.025 0 0
Specification of the neural plate border R-HSA-9834899 9.433674e-01 0.025 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.433674e-01 0.025 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.433674e-01 0.025 0 0
DNA Replication R-HSA-69306 9.458769e-01 0.024 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.467110e-01 0.024 0 0
Proteasome assembly R-HSA-9907900 9.472747e-01 0.024 0 0
Muscle contraction R-HSA-397014 9.484676e-01 0.023 0 0
Mitochondrial biogenesis R-HSA-1592230 9.495664e-01 0.022 0 0
Glycogen synthesis R-HSA-3322077 9.497576e-01 0.022 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.497576e-01 0.022 0 0
Pregnenolone biosynthesis R-HSA-196108 9.497576e-01 0.022 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.497576e-01 0.022 0 0
Downstream TCR signaling R-HSA-202424 9.502850e-01 0.022 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.506329e-01 0.022 0 0
Platelet degranulation R-HSA-114608 9.510146e-01 0.022 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.516951e-01 0.022 0 0
Somitogenesis R-HSA-9824272 9.516951e-01 0.022 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.517282e-01 0.021 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.517282e-01 0.021 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.517282e-01 0.021 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.554271e-01 0.020 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.554271e-01 0.020 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.554271e-01 0.020 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.554271e-01 0.020 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.554271e-01 0.020 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.554271e-01 0.020 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.554271e-01 0.020 0 0
SLC transporter disorders R-HSA-5619102 9.554469e-01 0.020 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.557674e-01 0.020 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.557674e-01 0.020 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.557674e-01 0.020 1 1
HCMV Late Events R-HSA-9610379 9.559475e-01 0.020 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.562921e-01 0.019 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.562921e-01 0.019 0 0
eNOS activation R-HSA-203615 9.562921e-01 0.019 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.562921e-01 0.019 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.562921e-01 0.019 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.562921e-01 0.019 0 0
Signal amplification R-HSA-392518 9.562921e-01 0.019 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.564923e-01 0.019 0 0
Interleukin-1 signaling R-HSA-9020702 9.564987e-01 0.019 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.571167e-01 0.019 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.593265e-01 0.018 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.595165e-01 0.018 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.595273e-01 0.018 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.595273e-01 0.018 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.604411e-01 0.018 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.604411e-01 0.018 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.604411e-01 0.018 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.604411e-01 0.018 0 0
CS-GAG biosynthesis R-HSA-2022870 9.604571e-01 0.018 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.604571e-01 0.018 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.604571e-01 0.018 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.604571e-01 0.018 0 0
Serine metabolism R-HSA-977347 9.604571e-01 0.018 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.619929e-01 0.017 0 0
GPER1 signaling R-HSA-9634597 9.629656e-01 0.016 0 0
Metal ion SLC transporters R-HSA-425410 9.629656e-01 0.016 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.641747e-01 0.016 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.642105e-01 0.016 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.642105e-01 0.016 0 0
Toll-like Receptor Cascades R-HSA-168898 9.647123e-01 0.016 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.649197e-01 0.016 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.649197e-01 0.016 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.649197e-01 0.016 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.649197e-01 0.016 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.655676e-01 0.015 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.661366e-01 0.015 0 0
RSV-host interactions R-HSA-9833110 9.664476e-01 0.015 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.676333e-01 0.014 0 0
Degradation of AXIN R-HSA-4641257 9.676333e-01 0.014 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.676333e-01 0.014 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.688789e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.688789e-01 0.014 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.707397e-01 0.013 0 0
Elastic fibre formation R-HSA-1566948 9.707397e-01 0.013 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.707397e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.717254e-01 0.012 1 0
Plasma lipoprotein assembly R-HSA-8963898 9.723915e-01 0.012 0 0
Complex III assembly R-HSA-9865881 9.723915e-01 0.012 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.723915e-01 0.012 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.723915e-01 0.012 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.723915e-01 0.012 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.723915e-01 0.012 0 0
Interleukin-6 family signaling R-HSA-6783589 9.723915e-01 0.012 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.732627e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.739312e-01 0.011 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.741805e-01 0.011 0 0
Integration of energy metabolism R-HSA-163685 9.742272e-01 0.011 0 0
Cellular response to hypoxia R-HSA-1234174 9.745125e-01 0.011 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.755079e-01 0.011 0 0
Hyaluronan degradation R-HSA-2160916 9.755079e-01 0.011 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.755079e-01 0.011 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.755079e-01 0.011 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.758989e-01 0.011 0 0
ER-Phagosome pathway R-HSA-1236974 9.760201e-01 0.011 0 0
Glycogen metabolism R-HSA-8982491 9.761120e-01 0.011 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.761120e-01 0.011 0 0
Ion channel transport R-HSA-983712 9.769970e-01 0.010 0 0
ABC-family proteins mediated transport R-HSA-382556 9.782370e-01 0.010 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.782726e-01 0.010 0 0
TRP channels R-HSA-3295583 9.782726e-01 0.010 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.782726e-01 0.010 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.782726e-01 0.010 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.784271e-01 0.009 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.784271e-01 0.009 0 0
Maturation of spike protein R-HSA-9694548 9.784271e-01 0.009 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.784964e-01 0.009 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.805240e-01 0.009 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.805240e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9683701 9.805240e-01 0.009 0 0
Packaging Of Telomere Ends R-HSA-171306 9.807254e-01 0.008 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.807254e-01 0.008 0 0
Signaling by BMP R-HSA-201451 9.807254e-01 0.008 0 0
Insulin processing R-HSA-264876 9.807254e-01 0.008 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.807254e-01 0.008 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.809796e-01 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.821191e-01 0.008 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.822469e-01 0.008 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.824226e-01 0.008 0 0
Insulin receptor recycling R-HSA-77387 9.829014e-01 0.007 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.829014e-01 0.007 0 0
Pyrimidine salvage R-HSA-73614 9.829014e-01 0.007 0 0
Hemostasis R-HSA-109582 9.830265e-01 0.007 0 0
Dectin-2 family R-HSA-5621480 9.837039e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.848318e-01 0.007 0 0
Neutrophil degranulation R-HSA-6798695 9.855142e-01 0.006 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.856871e-01 0.006 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.856871e-01 0.006 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.856871e-01 0.006 0 0
Surfactant metabolism R-HSA-5683826 9.856954e-01 0.006 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.856954e-01 0.006 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.856954e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.864794e-01 0.006 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.864794e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.865265e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.865265e-01 0.006 0 0
Neurotransmitter clearance R-HSA-112311 9.865445e-01 0.006 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.869370e-01 0.006 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.871011e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.876909e-01 0.005 0 0
Cellular response to starvation R-HSA-9711097 9.877123e-01 0.005 0 0
Developmental Cell Lineages R-HSA-9734767 9.881170e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.887152e-01 0.005 0 0
HS-GAG degradation R-HSA-2024096 9.894116e-01 0.005 0 0
DAG1 glycosylations R-HSA-8931838 9.894116e-01 0.005 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.894116e-01 0.005 0 0
Diseases of programmed cell death R-HSA-9645723 9.900962e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.905576e-01 0.004 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.916681e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.916681e-01 0.004 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.916681e-01 0.004 0 0
Heme degradation R-HSA-189483 9.916681e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.917118e-01 0.004 0 0
Interleukin-10 signaling R-HSA-6783783 9.917118e-01 0.004 0 0
Protein localization R-HSA-9609507 9.917485e-01 0.004 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.922879e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.926091e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.926091e-01 0.003 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.926091e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.927787e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.930395e-01 0.003 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.931034e-01 0.003 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.931034e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.933003e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.934439e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.934831e-01 0.003 0 0
FCGR activation R-HSA-2029481 9.940122e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.941845e-01 0.003 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.941845e-01 0.003 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.941845e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.947029e-01 0.002 0 0
Cleavage of the damaged purine R-HSA-110331 9.948414e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.948414e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.948414e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.948666e-01 0.002 0 0
Ribosome-associated quality control R-HSA-9948299 9.950058e-01 0.002 0 0
Eukaryotic Translation Termination R-HSA-72764 9.953640e-01 0.002 0 0
Depurination R-HSA-73927 9.954242e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.954242e-01 0.002 0 0
Hedgehog 'on' state R-HSA-5632684 9.957068e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.957068e-01 0.002 0 0
Stimuli-sensing channels R-HSA-2672351 9.957242e-01 0.002 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.960072e-01 0.002 0 0
Interleukin-1 family signaling R-HSA-446652 9.960072e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.961055e-01 0.002 0 0
Cardiac conduction R-HSA-5576891 9.963188e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.963428e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.963997e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.963997e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.967363e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.968065e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.969264e-01 0.001 0 0
Peptide chain elongation R-HSA-156902 9.969345e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.970446e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.973440e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.974874e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.974874e-01 0.001 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.974874e-01 0.001 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.974874e-01 0.001 0 0
Depyrimidination R-HSA-73928 9.974874e-01 0.001 0 0
Defective pyroptosis R-HSA-9710421 9.977714e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.977714e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.978559e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.979782e-01 0.001 0 0
Methylation R-HSA-156581 9.980232e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.980232e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.980232e-01 0.001 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.982466e-01 0.001 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.982466e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.983353e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.984000e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.984448e-01 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.985145e-01 0.001 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.985433e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.985643e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.986206e-01 0.001 0 0
Regulated Necrosis R-HSA-5218859 9.988766e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.990016e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.990375e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.990478e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.990921e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990955e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990955e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.991222e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.991463e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.991463e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.991885e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.991885e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.992497e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.992788e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.993285e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.993804e-01 0.000 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.994044e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.994709e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.994718e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.994718e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.995785e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.996177e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.996219e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.996611e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.996732e-01 0.000 0 0
Neddylation R-HSA-8951664 9.996784e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.997101e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.997101e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997131e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997142e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997279e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.997279e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997418e-01 0.000 0 0
Aquaporin-mediated transport R-HSA-445717 9.997429e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.997429e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997429e-01 0.000 0 0
Translation R-HSA-72766 9.997474e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997564e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997978e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998044e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998207e-01 0.000 0 0
Immune System R-HSA-168256 9.998735e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998749e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998749e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998749e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998891e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998891e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999098e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999128e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999172e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999226e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999226e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999226e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999337e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999392e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999461e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999483e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999485e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999522e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999677e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999696e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999704e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999731e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999731e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999741e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999785e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999802e-01 0.000 1 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999831e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999900e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999930e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999940e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999954e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999969e-01 0.000 0 0
Disease R-HSA-1643685 9.999970e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999972e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999973e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999979e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999989e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999991e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999991e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999995e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999995e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 1 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 1.554312e-15 14.808 0 0
Attenuation phase R-HSA-3371568 1.254552e-14 13.902 0 0
Cellular response to heat stress R-HSA-3371556 1.121325e-14 13.950 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.719247e-11 10.765 0 0
HSF1 activation R-HSA-3371511 1.947061e-10 9.711 0 0
Cell Cycle R-HSA-1640170 7.678106e-10 9.115 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.192632e-09 8.659 0 0
Metabolism of RNA R-HSA-8953854 2.622970e-09 8.581 0 0
Apoptotic execution phase R-HSA-75153 1.001611e-08 7.999 0 0
Cell Cycle, Mitotic R-HSA-69278 1.232391e-08 7.909 0 0
Mitotic Prometaphase R-HSA-68877 1.865995e-08 7.729 0 0
M Phase R-HSA-68886 2.030776e-08 7.692 0 0
Mitotic Anaphase R-HSA-68882 1.469853e-07 6.833 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.652079e-07 6.782 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.778508e-07 6.750 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.507727e-07 6.601 0 0
Recycling pathway of L1 R-HSA-437239 2.948000e-07 6.530 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.492150e-07 6.457 0 0
PKR-mediated signaling R-HSA-9833482 6.049968e-07 6.218 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.099761e-07 6.149 0 0
Cellular responses to stress R-HSA-2262752 6.829214e-07 6.166 0 0
Separation of Sister Chromatids R-HSA-2467813 9.073584e-07 6.042 0 0
Interleukin-12 signaling R-HSA-9020591 9.630703e-07 6.016 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.026326e-06 5.989 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.953330e-06 5.709 0 0
Interleukin-12 family signaling R-HSA-447115 2.645344e-06 5.578 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.142278e-06 5.503 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.132371e-06 5.504 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.749408e-06 5.426 0 0
Cellular responses to stimuli R-HSA-8953897 3.756209e-06 5.425 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.436567e-06 5.353 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.776945e-06 5.321 0 0
Apoptosis R-HSA-109581 4.584253e-06 5.339 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.744656e-06 5.324 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.358530e-06 5.271 0 0
mRNA Splicing R-HSA-72172 7.241705e-06 5.140 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.564397e-06 5.121 0 0
Cell-Cell communication R-HSA-1500931 8.680999e-06 5.061 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.087233e-05 4.964 0 0
Signaling by ALK in cancer R-HSA-9700206 1.087233e-05 4.964 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.118506e-05 4.951 0 0
Aggrephagy R-HSA-9646399 1.265865e-05 4.898 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.559323e-05 4.807 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.537126e-05 4.813 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.608099e-05 4.794 0 0
Programmed Cell Death R-HSA-5357801 1.796292e-05 4.746 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.745116e-05 4.758 0 0
Smooth Muscle Contraction R-HSA-445355 1.923878e-05 4.716 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.126627e-05 4.672 0 0
Post NMDA receptor activation events R-HSA-438064 2.497665e-05 4.602 0 0
G2/M Transition R-HSA-69275 2.851196e-05 4.545 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.027334e-05 4.519 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.027334e-05 4.519 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.137781e-05 4.503 0 0
Gap junction trafficking and regulation R-HSA-157858 3.069054e-05 4.513 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.524296e-05 4.453 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.465932e-05 4.460 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.890011e-05 4.410 0 0
Gap junction trafficking R-HSA-190828 3.965485e-05 4.402 0 0
L1CAM interactions R-HSA-373760 4.665413e-05 4.331 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.624698e-05 4.250 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.689191e-05 4.175 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.654687e-05 4.015 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.939156e-04 3.712 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.939156e-04 3.712 0 0
Cilium Assembly R-HSA-5617833 1.932801e-04 3.714 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.991756e-04 3.701 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.170828e-04 3.663 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.156212e-04 3.666 0 0
Nephrin family interactions R-HSA-373753 2.815650e-04 3.550 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.053031e-04 3.515 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.102359e-04 3.508 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.717300e-04 3.430 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.717300e-04 3.430 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.717300e-04 3.430 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.717300e-04 3.430 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.468304e-04 3.460 0 0
Cell junction organization R-HSA-446728 3.828230e-04 3.417 0 0
EPH-Ephrin signaling R-HSA-2682334 4.241322e-04 3.372 0 0
Adherens junctions interactions R-HSA-418990 4.841815e-04 3.315 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.221304e-04 3.282 0 0
Striated Muscle Contraction R-HSA-390522 6.006389e-04 3.221 0 0
Cell Cycle Checkpoints R-HSA-69620 6.326120e-04 3.199 0 0
Muscle contraction R-HSA-397014 6.019015e-04 3.220 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.389600e-04 3.195 0 0
Chromatin organization R-HSA-4839726 6.391735e-04 3.194 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.418662e-04 3.193 0 0
rRNA processing R-HSA-72312 6.945964e-04 3.158 0 0
Gap junction assembly R-HSA-190861 7.327222e-04 3.135 0 0
Chromatin modifying enzymes R-HSA-3247509 7.980209e-04 3.098 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.235550e-04 3.084 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.235550e-04 3.084 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.416690e-04 3.075 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.507161e-04 3.070 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.880686e-04 3.052 0 0
Protein folding R-HSA-391251 1.052466e-03 2.978 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.145983e-03 2.941 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.145983e-03 2.941 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.145983e-03 2.941 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.097794e-03 2.959 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.246272e-03 2.904 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.269184e-03 2.896 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.269184e-03 2.896 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.274075e-03 2.895 0 0
Selective autophagy R-HSA-9663891 1.463138e-03 2.835 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.495589e-03 2.825 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.495589e-03 2.825 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.531934e-03 2.815 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.570726e-03 2.804 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.694555e-03 2.771 0 0
mRNA 3'-end processing R-HSA-72187 1.736399e-03 2.760 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.819256e-03 2.740 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.860618e-03 2.730 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.878608e-03 2.726 0 0
Kinesins R-HSA-983189 1.878608e-03 2.726 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.922357e-03 2.716 0 0
Nervous system development R-HSA-9675108 1.951596e-03 2.710 0 0
Disorders of Developmental Biology R-HSA-9675151 2.008659e-03 2.697 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.140917e-03 2.669 0 0
Membrane Trafficking R-HSA-199991 2.306140e-03 2.637 0 0
Axon guidance R-HSA-422475 2.277490e-03 2.643 0 0
Cell-cell junction organization R-HSA-421270 2.379312e-03 2.624 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.490766e-03 2.604 0 0
mTORC1-mediated signalling R-HSA-166208 2.552518e-03 2.593 0 0
Signaling by Hippo R-HSA-2028269 2.594956e-03 2.586 0 0
Hedgehog 'off' state R-HSA-5610787 2.673254e-03 2.573 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.795640e-03 2.554 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.997106e-03 2.523 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.756701e-03 2.560 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.756701e-03 2.560 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.826141e-03 2.549 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.912527e-03 2.536 0 0
MHC class II antigen presentation R-HSA-2132295 2.797634e-03 2.553 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.132471e-03 2.504 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.132471e-03 2.504 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.132471e-03 2.504 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.165429e-03 2.500 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.413159e-03 2.467 0 0
ALK mutants bind TKIs R-HSA-9700645 3.420919e-03 2.466 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.862795e-03 2.413 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.123365e-03 2.385 0 0
G2/M Checkpoints R-HSA-69481 4.226241e-03 2.374 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.597385e-03 2.337 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.666284e-03 2.331 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.789170e-03 2.320 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.157290e-03 2.288 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.328636e-03 2.273 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.089942e-03 2.293 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.424288e-03 2.266 0 0
ESR-mediated signaling R-HSA-8939211 5.525771e-03 2.258 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.832615e-03 2.234 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.911041e-03 2.228 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.911041e-03 2.228 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.911041e-03 2.228 0 0
Signaling by RAS mutants R-HSA-6802949 5.911041e-03 2.228 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.019117e-03 2.220 0 0
Translation initiation complex formation R-HSA-72649 6.131842e-03 2.212 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.150848e-03 2.211 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.168854e-03 2.210 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.475575e-03 2.189 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.730519e-03 2.172 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.698379e-03 2.114 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.698379e-03 2.114 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.698379e-03 2.114 0 0
Intraflagellar transport R-HSA-5620924 7.636280e-03 2.117 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.698379e-03 2.114 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.047783e-03 2.152 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.376675e-03 2.077 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.558488e-03 2.068 0 0
Regulation of CDH1 Function R-HSA-9764561 8.700045e-03 2.060 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.245751e-03 2.034 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.257606e-03 2.034 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.007762e-02 1.997 0 0
Centrosome maturation R-HSA-380287 1.018428e-02 1.992 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.087892e-02 1.963 0 0
Activation of BH3-only proteins R-HSA-114452 1.087892e-02 1.963 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.106219e-02 1.956 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.106401e-02 1.956 0 0
Disorders of Nervous System Development R-HSA-9697154 1.106401e-02 1.956 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.106401e-02 1.956 0 0
Pervasive developmental disorders R-HSA-9005895 1.106401e-02 1.956 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.208393e-02 1.918 0 0
Formation of annular gap junctions R-HSA-196025 1.357486e-02 1.867 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.279184e-02 1.893 0 0
Ephrin signaling R-HSA-3928664 1.279184e-02 1.893 0 0
Signaling by ERBB2 R-HSA-1227986 1.203855e-02 1.919 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.279184e-02 1.893 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.217456e-02 1.915 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.357486e-02 1.867 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.279184e-02 1.893 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.415761e-02 1.849 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.528185e-02 1.816 0 0
Long-term potentiation R-HSA-9620244 1.538101e-02 1.813 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.553333e-02 1.809 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.553333e-02 1.809 0 0
Semaphorin interactions R-HSA-373755 1.628233e-02 1.788 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.675088e-02 1.776 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.701606e-02 1.769 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.728745e-02 1.762 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.779234e-02 1.750 0 0
Gap junction degradation R-HSA-190873 1.804695e-02 1.744 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.827579e-02 1.738 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.860359e-02 1.730 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.926595e-02 1.715 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.968171e-02 1.706 0 0
Signaling by Hedgehog R-HSA-5358351 1.997485e-02 1.700 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.065271e-02 1.685 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.065871e-02 1.685 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.078016e-02 1.682 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.333760e-02 1.632 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.333760e-02 1.632 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.333760e-02 1.632 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.145951e-02 1.668 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.333760e-02 1.632 0 0
S Phase R-HSA-69242 2.179246e-02 1.662 0 0
MTOR signalling R-HSA-165159 2.445110e-02 1.612 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.122605e-02 1.673 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.326006e-02 1.633 0 0
Macroautophagy R-HSA-1632852 2.390931e-02 1.621 0 0
HIV Infection R-HSA-162906 2.457445e-02 1.610 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.559491e-02 1.592 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.576710e-02 1.589 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.576710e-02 1.589 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.614124e-02 1.583 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.614124e-02 1.583 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.740254e-02 1.562 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.773472e-02 1.557 0 0
RNA Polymerase III Transcription R-HSA-74158 2.773472e-02 1.557 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.773472e-02 1.557 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.895680e-02 1.538 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.905706e-02 1.537 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.977981e-02 1.526 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.026520e-02 1.519 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.106972e-02 1.508 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.106972e-02 1.508 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.111358e-02 1.507 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.114970e-02 1.507 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.183893e-02 1.497 0 0
Meiotic synapsis R-HSA-1221632 3.183893e-02 1.497 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.350657e-02 1.475 0 0
Autophagy R-HSA-9612973 3.387597e-02 1.470 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.526003e-02 1.453 0 0
HIV Life Cycle R-HSA-162587 3.568202e-02 1.448 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.899436e-02 1.409 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.648640e-02 1.438 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.674181e-02 1.435 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.674181e-02 1.435 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.168210e-02 1.380 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.869333e-02 1.412 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.173324e-02 1.380 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.161359e-02 1.381 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.299481e-02 1.367 0 0
Interferon Signaling R-HSA-913531 3.902948e-02 1.409 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.168210e-02 1.380 0 0
Signaling by ALK R-HSA-201556 3.869333e-02 1.412 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.315871e-02 1.365 0 0
Regulation of TP53 Expression R-HSA-6804754 4.342942e-02 1.362 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.342942e-02 1.362 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 4.342942e-02 1.362 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.437387e-02 1.353 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.451993e-02 1.351 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.451993e-02 1.351 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.495250e-02 1.347 0 0
Protein ubiquitination R-HSA-8852135 4.495250e-02 1.347 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.541097e-02 1.343 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.741755e-02 1.324 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.741755e-02 1.324 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.741755e-02 1.324 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.042995e-02 1.297 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.087625e-02 1.293 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.288231e-02 1.277 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.288231e-02 1.277 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.342341e-02 1.272 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.728235e-02 1.242 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.728235e-02 1.242 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.728235e-02 1.242 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.728235e-02 1.242 0 0
Ca-dependent events R-HSA-111996 5.733243e-02 1.242 0 0
Signaling by Interleukins R-HSA-449147 5.742441e-02 1.241 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.777800e-02 1.238 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 6.435955e-02 1.191 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 6.435955e-02 1.191 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 6.435955e-02 1.191 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.330003e-02 1.199 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.544964e-02 1.184 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.544964e-02 1.184 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.544964e-02 1.184 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.414035e-02 1.130 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.148073e-02 1.146 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.299920e-02 1.201 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.823736e-02 1.166 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.823736e-02 1.166 0 0
Nucleotide Excision Repair R-HSA-5696398 6.380740e-02 1.195 0 0
CaM pathway R-HSA-111997 6.737756e-02 1.171 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.362076e-02 1.196 0 0
Calmodulin induced events R-HSA-111933 6.737756e-02 1.171 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.556200e-02 1.183 0 0
Synthesis of DNA R-HSA-69239 7.126308e-02 1.147 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.401710e-02 1.131 0 0
RMTs methylate histone arginines R-HSA-3214858 6.846968e-02 1.165 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.322621e-02 1.135 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.435955e-02 1.191 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.544964e-02 1.184 0 0
Basigin interactions R-HSA-210991 6.544964e-02 1.184 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.716666e-02 1.173 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.470933e-02 1.127 0 0
FOXO-mediated transcription R-HSA-9614085 7.470933e-02 1.127 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.326226e-02 1.135 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.414035e-02 1.130 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.502442e-02 1.125 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.502442e-02 1.125 0 0
Signaling by VEGF R-HSA-194138 7.521684e-02 1.124 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.752317e-02 1.111 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.752317e-02 1.111 0 0
Unwinding of DNA R-HSA-176974 7.752317e-02 1.111 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.752317e-02 1.111 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.752317e-02 1.111 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.780019e-02 1.109 0 0
IRE1alpha activates chaperones R-HSA-381070 7.822865e-02 1.107 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 7.881929e-02 1.103 0 0
FLT3 mutants bind TKIs R-HSA-9702509 7.881929e-02 1.103 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 7.881929e-02 1.103 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 7.881929e-02 1.103 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 7.881929e-02 1.103 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 7.881929e-02 1.103 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 7.881929e-02 1.103 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 7.881929e-02 1.103 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 7.881929e-02 1.103 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 7.881929e-02 1.103 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 7.881929e-02 1.103 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 7.881929e-02 1.103 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 7.881929e-02 1.103 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 7.881929e-02 1.103 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 7.881929e-02 1.103 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 7.881929e-02 1.103 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 7.881929e-02 1.103 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 7.881929e-02 1.103 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 7.881929e-02 1.103 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.950890e-02 1.100 0 0
Vesicle-mediated transport R-HSA-5653656 7.972769e-02 1.098 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.084584e-02 1.092 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.084584e-02 1.092 0 0
Homology Directed Repair R-HSA-5693538 8.329215e-02 1.079 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.342612e-02 1.079 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.342612e-02 1.079 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.342612e-02 1.079 0 0
Phosphorylation of the APC/C R-HSA-176412 8.457736e-02 1.073 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.457736e-02 1.073 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 8.793343e-02 1.056 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.793343e-02 1.056 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.136049e-01 0.945 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.136049e-01 0.945 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.136049e-01 0.945 0 0
2-LTR circle formation R-HSA-164843 9.300489e-02 1.031 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.668951e-02 1.015 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.037329e-01 0.984 0 0
Deadenylation of mRNA R-HSA-429947 1.037329e-01 0.984 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.042695e-01 0.982 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.749949e-02 1.058 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.554385e-02 1.068 0 0
Dual incision in TC-NER R-HSA-6782135 9.841086e-02 1.007 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.073111e-01 0.969 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.029317e-01 0.987 0 0
PTEN Regulation R-HSA-6807070 9.818844e-02 1.008 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.133542e-01 0.946 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.037329e-01 0.984 0 0
DNA strand elongation R-HSA-69190 9.621862e-02 1.017 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.136049e-01 0.945 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.621862e-02 1.017 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.678308e-02 1.062 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.668951e-02 1.015 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.615824e-02 1.017 0 0
DNA Double Strand Break Response R-HSA-5693606 9.468047e-02 1.024 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.017684e-01 0.992 0 0
NADE modulates death signalling R-HSA-205025 8.793343e-02 1.056 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.136049e-01 0.945 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.095625e-01 0.960 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.749949e-02 1.058 0 0
MAP2K and MAPK activation R-HSA-5674135 1.127380e-01 0.948 0 0
Mitotic Prophase R-HSA-68875 9.176208e-02 1.037 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.136049e-01 0.945 0 0
Gene expression (Transcription) R-HSA-74160 9.014996e-02 1.045 0 0
Bicarbonate transporters R-HSA-425381 1.096416e-01 0.960 0 0
Host Interactions of HIV factors R-HSA-162909 1.102826e-01 0.957 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 8.793343e-02 1.056 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.136049e-01 0.945 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.059847e-01 0.975 0 0
Influenza Infection R-HSA-168255 9.918010e-02 1.004 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.096416e-01 0.960 0 0
Sensory processing of sound R-HSA-9659379 1.083530e-01 0.965 0 0
Neurodegenerative Diseases R-HSA-8863678 1.037329e-01 0.984 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.037329e-01 0.984 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.668951e-02 1.015 0 0
Metal ion SLC transporters R-HSA-425410 9.446212e-02 1.025 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.554385e-02 1.068 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.136049e-01 0.945 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.139709e-01 0.943 0 0
TGFBR3 expression R-HSA-9839394 1.147211e-01 0.940 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.149352e-01 0.940 0 0
Ub-specific processing proteases R-HSA-5689880 1.176117e-01 0.930 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.197712e-01 0.922 0 0
GAB1 signalosome R-HSA-180292 1.231554e-01 0.910 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.231554e-01 0.910 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.231554e-01 0.910 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.231554e-01 0.910 0 0
RAF activation R-HSA-5673000 1.249314e-01 0.903 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.249314e-01 0.903 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.262391e-01 0.899 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.262391e-01 0.899 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.272831e-01 0.895 0 0
Activation of RAC1 R-HSA-428540 1.273237e-01 0.895 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.273237e-01 0.895 0 0
Integration of provirus R-HSA-162592 1.273237e-01 0.895 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.273237e-01 0.895 0 0
DNA Repair R-HSA-73894 1.281149e-01 0.892 0 0
Platelet degranulation R-HSA-114608 1.309052e-01 0.883 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.338003e-01 0.874 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.374237e-01 0.862 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.374237e-01 0.862 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.374237e-01 0.862 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.380996e-01 0.860 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.382639e-01 0.859 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.382639e-01 0.859 0 0
Cristae formation R-HSA-8949613 1.382639e-01 0.859 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.408975e-01 0.851 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.408975e-01 0.851 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.408975e-01 0.851 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.408975e-01 0.851 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.408975e-01 0.851 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.408975e-01 0.851 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.417276e-01 0.849 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.425388e-01 0.846 0 0
Signaling by NOTCH4 R-HSA-9013694 1.428507e-01 0.845 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.447576e-01 0.839 0 0
Repression of WNT target genes R-HSA-4641265 1.459387e-01 0.836 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.459387e-01 0.836 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.459387e-01 0.836 0 0
FLT3 signaling in disease R-HSA-9682385 1.461336e-01 0.835 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.469161e-01 0.833 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.489905e-01 0.827 0 0
DAG and IP3 signaling R-HSA-1489509 1.500297e-01 0.824 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.506137e-01 0.822 0 0
HIV elongation arrest and recovery R-HSA-167287 1.507703e-01 0.822 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.507703e-01 0.822 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.514304e-01 0.820 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.514304e-01 0.820 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.514304e-01 0.820 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.514304e-01 0.820 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.514304e-01 0.820 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.514304e-01 0.820 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.514304e-01 0.820 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.514304e-01 0.820 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.514304e-01 0.820 0 0
Inhibition of PKR R-HSA-169131 1.514304e-01 0.820 0 0
HDACs deacetylate histones R-HSA-3214815 1.515522e-01 0.819 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.523197e-01 0.817 0 0
Transmission across Chemical Synapses R-HSA-112315 1.543992e-01 0.811 0 0
Neutrophil degranulation R-HSA-6798695 1.551942e-01 0.809 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.573087e-01 0.803 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.183221e-01 0.661 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.183221e-01 0.661 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.183221e-01 0.661 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.183221e-01 0.661 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.183221e-01 0.661 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.693966e-01 0.771 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.987428e-01 0.702 0 0
Recycling of eIF2:GDP R-HSA-72731 1.987428e-01 0.702 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.062490e-01 0.686 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.062490e-01 0.686 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.062490e-01 0.686 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.274738e-01 0.643 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.002650e-01 0.698 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.909004e-01 0.719 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.344161e-01 0.630 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.344161e-01 0.630 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.195290e-01 0.659 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.343112e-01 0.630 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.343112e-01 0.630 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.801591e-01 0.744 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.312370e-01 0.636 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.640784e-01 0.785 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.386945e-01 0.622 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.251088e-01 0.648 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.251088e-01 0.648 0 0
Co-inhibition by PD-1 R-HSA-389948 1.980379e-01 0.703 0 0
Signaling by EGFR R-HSA-177929 1.608327e-01 0.794 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.291952e-01 0.640 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.054174e-01 0.687 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.684072e-01 0.774 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.062490e-01 0.686 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.344161e-01 0.630 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.966439e-01 0.706 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.286260e-01 0.641 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.062800e-01 0.686 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.062800e-01 0.686 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.929177e-01 0.715 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.733323e-01 0.761 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.688435e-01 0.773 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.653727e-01 0.782 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.771178e-01 0.752 0 0
PLC beta mediated events R-HSA-112043 2.109138e-01 0.676 0 0
Meiosis R-HSA-1500620 2.387767e-01 0.622 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.014694e-01 0.696 0 0
TCR signaling R-HSA-202403 2.092220e-01 0.679 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.183221e-01 0.661 0 0
Trafficking of AMPA receptors R-HSA-399719 1.909004e-01 0.719 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.807197e-01 0.743 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.929177e-01 0.715 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.267588e-01 0.644 0 0
Orc1 removal from chromatin R-HSA-68949 2.267588e-01 0.644 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.855130e-01 0.732 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.195290e-01 0.659 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.294910e-01 0.639 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.274738e-01 0.643 0 0
Signal Transduction R-HSA-162582 2.361537e-01 0.627 0 0
Cellular Senescence R-HSA-2559583 2.108174e-01 0.676 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.693966e-01 0.771 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.286260e-01 0.641 0 0
Protein methylation R-HSA-8876725 2.062490e-01 0.686 0 0
Signaling by TGFBR3 R-HSA-9839373 1.601590e-01 0.795 0 0
Sodium/Proton exchangers R-HSA-425986 2.286260e-01 0.641 0 0
Potential therapeutics for SARS R-HSA-9679191 2.253976e-01 0.647 0 0
Viral Infection Pathways R-HSA-9824446 1.878782e-01 0.726 0 0
Zinc transporters R-HSA-435354 1.855130e-01 0.732 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.195290e-01 0.659 0 0
Signaling by ROBO receptors R-HSA-376176 2.152110e-01 0.667 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.719026e-01 0.765 0 0
Nef and signal transduction R-HSA-164944 1.693966e-01 0.771 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.987428e-01 0.702 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.161403e-01 0.665 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.790234e-01 0.747 0 0
HCMV Early Events R-HSA-9609690 2.407646e-01 0.618 0 0
Developmental Cell Lineages R-HSA-9734767 2.413660e-01 0.617 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.799444e-01 0.553 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.367122e-01 0.473 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.367122e-01 0.473 0 0
MET activates PTPN11 R-HSA-8865999 3.367122e-01 0.473 0 0
ARMS-mediated activation R-HSA-170984 2.587792e-01 0.587 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.587792e-01 0.587 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.587792e-01 0.587 0 0
Calcineurin activates NFAT R-HSA-2025928 2.587792e-01 0.587 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.890076e-01 0.410 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.890076e-01 0.410 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.890076e-01 0.410 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.890076e-01 0.410 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.890076e-01 0.410 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.371828e-01 0.359 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.371828e-01 0.359 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.371828e-01 0.359 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 4.371828e-01 0.359 0 0
Defective F9 activation R-HSA-9673221 4.371828e-01 0.359 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.371828e-01 0.359 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.709836e-01 0.567 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.709836e-01 0.567 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.487467e-01 0.457 0 0
PKA activation R-HSA-163615 2.930787e-01 0.533 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.930787e-01 0.533 0 0
Leading Strand Synthesis R-HSA-69109 3.780229e-01 0.422 0 0
Polymerase switching R-HSA-69091 3.780229e-01 0.422 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.780229e-01 0.422 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.815622e-01 0.317 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.815622e-01 0.317 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.815622e-01 0.317 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.815622e-01 0.317 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.815622e-01 0.317 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.493622e-01 0.603 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.493622e-01 0.603 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.493622e-01 0.603 0 0
Dual Incision in GG-NER R-HSA-5696400 2.493622e-01 0.603 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.375179e-01 0.472 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.375179e-01 0.472 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 3.375179e-01 0.472 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.060742e-01 0.514 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.060742e-01 0.514 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.067335e-01 0.391 0 0
Lagging Strand Synthesis R-HSA-69186 3.597074e-01 0.444 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.716889e-01 0.566 0 0
Nucleosome assembly R-HSA-774815 2.716889e-01 0.566 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.427823e-01 0.465 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.427823e-01 0.465 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.347859e-01 0.362 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.347859e-01 0.362 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.347859e-01 0.362 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.275178e-01 0.485 0 0
EGFR downregulation R-HSA-182971 3.611944e-01 0.442 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.611944e-01 0.442 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.611944e-01 0.442 0 0
Notch-HLH transcription pathway R-HSA-350054 4.036859e-01 0.394 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.435086e-01 0.464 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.583611e-01 0.588 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.621054e-01 0.335 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.621054e-01 0.335 0 0
Metabolism of non-coding RNA R-HSA-194441 3.138732e-01 0.503 0 0
snRNP Assembly R-HSA-191859 3.138732e-01 0.503 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.253565e-01 0.371 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.979273e-01 0.400 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.709958e-01 0.431 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.679110e-01 0.434 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.522446e-01 0.345 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.395344e-01 0.357 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.553131e-01 0.342 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.367812e-01 0.360 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.583857e-01 0.339 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.482330e-01 0.348 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.843337e-01 0.315 0 0
Transcription of the HIV genome R-HSA-167172 4.321703e-01 0.364 0 0
HIV Transcription Elongation R-HSA-167169 3.435086e-01 0.464 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.709836e-01 0.567 0 0
Ribosome-associated quality control R-HSA-9948299 2.964978e-01 0.528 0 0
Activation of the pre-replicative complex R-HSA-68962 3.427823e-01 0.465 0 0
Generation of second messenger molecules R-HSA-202433 3.435086e-01 0.464 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.801404e-01 0.553 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.435086e-01 0.464 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.580049e-01 0.588 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.606803e-01 0.443 0 0
DARPP-32 events R-HSA-180024 3.243943e-01 0.489 0 0
DCC mediated attractive signaling R-HSA-418885 4.621054e-01 0.335 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.490845e-01 0.604 0 0
Regulation of CDH11 function R-HSA-9762292 2.889746e-01 0.539 0 0
Regulation of Apoptosis R-HSA-169911 2.646494e-01 0.577 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.275178e-01 0.485 0 0
Signal amplification R-HSA-392518 2.493622e-01 0.603 0 0
Chromosome Maintenance R-HSA-73886 4.306850e-01 0.366 0 0
Myogenesis R-HSA-525793 2.698228e-01 0.569 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.161718e-01 0.381 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.114056e-01 0.507 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.587792e-01 0.587 0 0
Regulation of gap junction activity R-HSA-191650 3.890076e-01 0.410 0 0
NF-kB is activated and signals survival R-HSA-209560 3.487467e-01 0.457 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.979273e-01 0.400 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.376175e-01 0.472 0 0
Nuclear RNA decay R-HSA-9930044 3.979273e-01 0.400 0 0
ER-Phagosome pathway R-HSA-1236974 2.886673e-01 0.540 0 0
Nuclear import of Rev protein R-HSA-180746 2.493622e-01 0.603 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.855429e-01 0.544 0 0
RNA Polymerase I Transcription R-HSA-73864 4.102939e-01 0.387 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.882453e-01 0.540 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.371828e-01 0.359 0 0
Activation of AKT2 R-HSA-165158 4.371828e-01 0.359 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.371828e-01 0.359 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.780229e-01 0.422 0 0
Negative regulation of MET activity R-HSA-6807004 3.375179e-01 0.472 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.595488e-01 0.444 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.916648e-01 0.407 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.304516e-01 0.481 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.522446e-01 0.345 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.519886e-01 0.599 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.698228e-01 0.569 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.189948e-01 0.378 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.698228e-01 0.569 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.890076e-01 0.410 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.890076e-01 0.410 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 4.371828e-01 0.359 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.855429e-01 0.544 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.036859e-01 0.394 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.138732e-01 0.503 0 0
Complex III assembly R-HSA-9865881 4.467457e-01 0.350 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.582820e-01 0.588 0 0
eNOS activation R-HSA-203615 4.342883e-01 0.362 0 0
Opioid Signalling R-HSA-111885 4.707110e-01 0.327 0 0
DNA Replication R-HSA-69306 2.465100e-01 0.608 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.597074e-01 0.444 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.243943e-01 0.489 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.076870e-01 0.390 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.382752e-01 0.471 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.756100e-01 0.425 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.471612e-01 0.459 0 0
p75NTR signals via NF-kB R-HSA-193639 4.621054e-01 0.335 0 0
HATs acetylate histones R-HSA-3214847 2.972517e-01 0.527 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.471612e-01 0.459 0 0
Mismatch Repair R-HSA-5358508 2.930787e-01 0.533 0 0
RNA Polymerase II Transcription R-HSA-73857 4.004782e-01 0.397 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.979273e-01 0.400 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.275178e-01 0.485 0 0
G-protein mediated events R-HSA-112040 2.776590e-01 0.556 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.799444e-01 0.553 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.799444e-01 0.553 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.890076e-01 0.410 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.890076e-01 0.410 0 0
vRNP Assembly R-HSA-192905 3.190183e-01 0.496 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.371828e-01 0.359 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 4.815622e-01 0.317 0 0
PDE3B signalling R-HSA-165160 4.815622e-01 0.317 0 0
PKB-mediated events R-HSA-109703 4.815622e-01 0.317 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 4.815622e-01 0.317 0 0
Cam-PDE 1 activation R-HSA-111957 4.815622e-01 0.317 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.060742e-01 0.514 0 0
Platelet calcium homeostasis R-HSA-418360 3.243943e-01 0.489 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.621054e-01 0.335 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.395344e-01 0.357 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.698228e-01 0.569 0 0
Signaling by WNT R-HSA-195721 3.093944e-01 0.509 0 0
Stabilization of p53 R-HSA-69541 3.275178e-01 0.485 0 0
G alpha (12/13) signalling events R-HSA-416482 4.102939e-01 0.387 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.583857e-01 0.339 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.047865e-01 0.516 0 0
MAPK family signaling cascades R-HSA-5683057 3.225797e-01 0.491 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.601025e-01 0.337 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.709664e-01 0.327 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.700112e-01 0.328 0 0
tRNA processing in the nucleus R-HSA-6784531 3.530057e-01 0.452 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.161718e-01 0.381 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.236515e-01 0.373 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.395344e-01 0.357 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.511515e-01 0.346 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.765840e-01 0.322 0 0
HCMV Infection R-HSA-9609646 4.578097e-01 0.339 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.595488e-01 0.444 0 0
Ion homeostasis R-HSA-5578775 2.756195e-01 0.560 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.709664e-01 0.327 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.890076e-01 0.410 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.371828e-01 0.359 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.815622e-01 0.317 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.493622e-01 0.603 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.565849e-01 0.448 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.161718e-01 0.381 0 0
Iron uptake and transport R-HSA-917937 3.735244e-01 0.428 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.949382e-01 0.403 0 0
Maturation of spike protein R-HSA-9683686 2.889746e-01 0.539 0 0
Pyroptosis R-HSA-5620971 3.060742e-01 0.514 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.756100e-01 0.425 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.726429e-01 0.429 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.460991e-01 0.461 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.661686e-01 0.436 0 0
Signaling by PTK6 R-HSA-8848021 3.661686e-01 0.436 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.597074e-01 0.444 0 0
HDMs demethylate histones R-HSA-3214842 4.678084e-01 0.330 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.069569e-01 0.513 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.367122e-01 0.473 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.367122e-01 0.473 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 2.587792e-01 0.587 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.587792e-01 0.587 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.487467e-01 0.457 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.487467e-01 0.457 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.930787e-01 0.533 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.597074e-01 0.444 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.435086e-01 0.464 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.795892e-01 0.421 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.522446e-01 0.345 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.522446e-01 0.345 0 0
Developmental Biology R-HSA-1266738 4.314498e-01 0.365 0 0
Hedgehog 'on' state R-HSA-5632684 4.713993e-01 0.327 0 0
Glycolysis R-HSA-70171 3.070883e-01 0.513 0 0
Protein hydroxylation R-HSA-9629569 3.375179e-01 0.472 0 0
Degradation of CDH1 R-HSA-9766229 3.279016e-01 0.484 0 0
Deubiquitination R-HSA-5688426 2.605328e-01 0.584 0 0
NRAGE signals death through JNK R-HSA-193648 4.286336e-01 0.368 0 0
Degradation of DVL R-HSA-4641258 4.875607e-01 0.312 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.979273e-01 0.400 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.279016e-01 0.484 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.036859e-01 0.394 0 0
Regulated Necrosis R-HSA-5218859 4.321703e-01 0.364 0 0
Neurexins and neuroligins R-HSA-6794361 3.709958e-01 0.431 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.843337e-01 0.315 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.161718e-01 0.381 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.367122e-01 0.473 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.889746e-01 0.539 0 0
Sodium/Calcium exchangers R-HSA-425561 3.487467e-01 0.457 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 4.815622e-01 0.317 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.375179e-01 0.472 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.257859e-01 0.487 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.700112e-01 0.328 0 0
Degradation of AXIN R-HSA-4641257 4.875607e-01 0.312 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.875607e-01 0.312 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.583857e-01 0.339 0 0
G1/S Transition R-HSA-69206 3.660673e-01 0.436 0 0
Signaling by NOTCH3 R-HSA-9012852 4.142633e-01 0.383 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.865657e-01 0.413 0 0
Non-canonical inflammasome activation R-HSA-9686114 4.347859e-01 0.362 0 0
Gluconeogenesis R-HSA-70263 4.864743e-01 0.313 0 0
Biotin transport and metabolism R-HSA-196780 4.621054e-01 0.335 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.979273e-01 0.400 0 0
Death Receptor Signaling R-HSA-73887 2.537184e-01 0.596 0 0
Interleukin-1 signaling R-HSA-9020702 4.383300e-01 0.358 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.587792e-01 0.587 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.587792e-01 0.587 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 4.371828e-01 0.359 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.815622e-01 0.317 0 0
Signal regulatory protein family interactions R-HSA-391160 4.347859e-01 0.362 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.253565e-01 0.371 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.161718e-01 0.381 0 0
Interleukin-7 signaling R-HSA-1266695 4.678084e-01 0.330 0 0
Diseases of programmed cell death R-HSA-9645723 4.023226e-01 0.395 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.889746e-01 0.539 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.487467e-01 0.457 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.815622e-01 0.317 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.817841e-01 0.418 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.253565e-01 0.371 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.735244e-01 0.428 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.435086e-01 0.464 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.371828e-01 0.359 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.371828e-01 0.359 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.979273e-01 0.400 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.597074e-01 0.444 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.332221e-01 0.477 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 2.498256e-01 0.602 0 0
Metalloprotease DUBs R-HSA-5689901 4.885049e-01 0.311 0 0
Negative regulation of FLT3 R-HSA-9706369 4.886333e-01 0.311 0 0
Activation of SMO R-HSA-5635838 4.886333e-01 0.311 0 0
Prolonged ERK activation events R-HSA-169893 4.886333e-01 0.311 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.886333e-01 0.311 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.886333e-01 0.311 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.886333e-01 0.311 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.886333e-01 0.311 0 0
Atorvastatin ADME R-HSA-9754706 4.886333e-01 0.311 0 0
Virus Assembly and Release R-HSA-168268 4.886333e-01 0.311 0 0
Regulation of TP53 Activity R-HSA-5633007 4.946263e-01 0.306 0 0
Signaling by TGFB family members R-HSA-9006936 4.946263e-01 0.306 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.953037e-01 0.305 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.018181e-01 0.299 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.018181e-01 0.299 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.048683e-01 0.297 0 0
Glucose metabolism R-HSA-70326 5.108922e-01 0.292 0 0
Mitochondrial protein import R-HSA-1268020 5.131077e-01 0.290 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.143244e-01 0.289 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.143244e-01 0.289 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.143244e-01 0.289 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.143244e-01 0.289 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.143244e-01 0.289 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.143244e-01 0.289 0 0
Translation R-HSA-72766 5.190381e-01 0.285 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.219114e-01 0.282 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.219114e-01 0.282 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.223261e-01 0.282 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.224446e-01 0.282 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.224446e-01 0.282 0 0
Signaling by LTK in cancer R-HSA-9842640 5.224446e-01 0.282 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.224446e-01 0.282 0 0
STAT5 Activation R-HSA-9645135 5.224446e-01 0.282 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.224446e-01 0.282 0 0
Abacavir transmembrane transport R-HSA-2161517 5.224446e-01 0.282 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.224446e-01 0.282 0 0
CREB phosphorylation R-HSA-199920 5.224446e-01 0.282 0 0
VLDL assembly R-HSA-8866423 5.224446e-01 0.282 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.224446e-01 0.282 0 0
Neurofascin interactions R-HSA-447043 5.224446e-01 0.282 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.226662e-01 0.282 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.237734e-01 0.281 0 0
Neuronal System R-HSA-112316 5.312614e-01 0.275 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.319452e-01 0.274 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.350508e-01 0.272 0 0
Reproduction R-HSA-1474165 5.373253e-01 0.270 0 0
SARS-CoV Infections R-HSA-9679506 5.374075e-01 0.270 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.386695e-01 0.269 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.391460e-01 0.268 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.391460e-01 0.268 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.391460e-01 0.268 0 0
Specification of primordial germ cells R-HSA-9827857 5.391460e-01 0.268 0 0
Peptide chain elongation R-HSA-156902 5.423215e-01 0.266 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.465752e-01 0.262 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.466978e-01 0.262 0 0
Late endosomal microautophagy R-HSA-9615710 5.480734e-01 0.261 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.480734e-01 0.261 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.480734e-01 0.261 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.489102e-01 0.260 0 0
Maturation of spike protein R-HSA-9694548 5.551245e-01 0.256 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.551245e-01 0.256 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.551245e-01 0.256 0 0
ABC-family proteins mediated transport R-HSA-382556 5.596028e-01 0.252 0 0
PCP/CE pathway R-HSA-4086400 5.596539e-01 0.252 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.601054e-01 0.252 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.601054e-01 0.252 0 0
Regulation of PTEN localization R-HSA-8948747 5.601054e-01 0.252 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.601054e-01 0.252 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.601054e-01 0.252 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.601054e-01 0.252 0 0
PTK6 Expression R-HSA-8849473 5.601054e-01 0.252 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.601054e-01 0.252 0 0
LDL remodeling R-HSA-8964041 5.601054e-01 0.252 0 0
VLDL clearance R-HSA-8964046 5.601054e-01 0.252 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.601054e-01 0.252 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.601054e-01 0.252 0 0
CHL1 interactions R-HSA-447041 5.601054e-01 0.252 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.630753e-01 0.249 0 0
PKA activation in glucagon signalling R-HSA-164378 5.630753e-01 0.249 0 0
Apoptotic factor-mediated response R-HSA-111471 5.630753e-01 0.249 0 0
Inositol phosphate metabolism R-HSA-1483249 5.649338e-01 0.248 0 0
Downstream TCR signaling R-HSA-202424 5.651751e-01 0.248 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.670037e-01 0.246 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.670037e-01 0.246 0 0
Intra-Golgi traffic R-HSA-6811438 5.712604e-01 0.243 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.712604e-01 0.243 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.712604e-01 0.243 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.712604e-01 0.243 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.836581e-01 0.234 0 0
Budding and maturation of HIV virion R-HSA-162588 5.854384e-01 0.233 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.854384e-01 0.233 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.860987e-01 0.232 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.860987e-01 0.232 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.860987e-01 0.232 0 0
The NLRP3 inflammasome R-HSA-844456 5.860987e-01 0.232 0 0
Rap1 signalling R-HSA-392517 5.860987e-01 0.232 0 0
Maturation of nucleoprotein R-HSA-9694631 5.860987e-01 0.232 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.870631e-01 0.231 0 0
Type I hemidesmosome assembly R-HSA-446107 5.947982e-01 0.226 0 0
RSK activation R-HSA-444257 5.947982e-01 0.226 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.947982e-01 0.226 0 0
phospho-PLA2 pathway R-HSA-111995 5.947982e-01 0.226 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.947982e-01 0.226 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.947982e-01 0.226 0 0
MET receptor recycling R-HSA-8875656 5.947982e-01 0.226 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.947982e-01 0.226 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.947982e-01 0.226 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.947982e-01 0.226 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.947982e-01 0.226 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 5.947982e-01 0.226 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.947982e-01 0.226 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.947982e-01 0.226 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.947982e-01 0.226 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.947982e-01 0.226 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.947982e-01 0.226 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.947982e-01 0.226 0 0
Interleukin-23 signaling R-HSA-9020933 5.947982e-01 0.226 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.949456e-01 0.226 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.015309e-01 0.221 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.016238e-01 0.221 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.025204e-01 0.220 0 0
G0 and Early G1 R-HSA-1538133 6.033635e-01 0.219 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.033635e-01 0.219 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.082103e-01 0.216 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.082103e-01 0.216 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.082103e-01 0.216 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.082103e-01 0.216 0 0
Signal transduction by L1 R-HSA-445144 6.082103e-01 0.216 0 0
Formation of definitive endoderm R-HSA-9823730 6.082103e-01 0.216 0 0
Proteasome assembly R-HSA-9907900 6.176220e-01 0.209 0 0
G-protein beta:gamma signalling R-HSA-397795 6.207681e-01 0.207 0 0
Integrin signaling R-HSA-354192 6.207681e-01 0.207 0 0
Cardiogenesis R-HSA-9733709 6.207681e-01 0.207 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.207681e-01 0.207 0 0
Hemostasis R-HSA-109582 6.215382e-01 0.207 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.267569e-01 0.203 0 0
Lipophagy R-HSA-9613354 6.267569e-01 0.203 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.267569e-01 0.203 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.267569e-01 0.203 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.267569e-01 0.203 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.267569e-01 0.203 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.267569e-01 0.203 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.267569e-01 0.203 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.294107e-01 0.201 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.294107e-01 0.201 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.294107e-01 0.201 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.294107e-01 0.201 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.294107e-01 0.201 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.304545e-01 0.200 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.323594e-01 0.199 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.323594e-01 0.199 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.323594e-01 0.199 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.323594e-01 0.199 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.323594e-01 0.199 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.323594e-01 0.199 0 0
Somitogenesis R-HSA-9824272 6.323594e-01 0.199 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.376446e-01 0.195 0 0
Eukaryotic Translation Termination R-HSA-72764 6.407981e-01 0.193 0 0
Gene Silencing by RNA R-HSA-211000 6.414086e-01 0.193 0 0
Extension of Telomeres R-HSA-180786 6.430420e-01 0.192 0 0
Signaling by NOTCH R-HSA-157118 6.452731e-01 0.190 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.467256e-01 0.189 1 1
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.497061e-01 0.187 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.497061e-01 0.187 0 0
Serine metabolism R-HSA-977347 6.497061e-01 0.187 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.497061e-01 0.187 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.509764e-01 0.186 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.539878e-01 0.184 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.557111e-01 0.183 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.557111e-01 0.183 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.557111e-01 0.183 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.557111e-01 0.183 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.557111e-01 0.183 0 0
Metabolism of polyamines R-HSA-351202 6.557111e-01 0.183 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.561967e-01 0.183 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.561967e-01 0.183 0 0
Binding and entry of HIV virion R-HSA-173107 6.561967e-01 0.183 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.561967e-01 0.183 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.561967e-01 0.183 0 0
DNA replication initiation R-HSA-68952 6.561967e-01 0.183 0 0
PAOs oxidise polyamines to amines R-HSA-141334 6.561967e-01 0.183 0 0
Pexophagy R-HSA-9664873 6.561967e-01 0.183 0 0
CASP4 inflammasome assembly R-HSA-9948001 6.561967e-01 0.183 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 6.561967e-01 0.183 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.561967e-01 0.183 0 0
Interleukin-27 signaling R-HSA-9020956 6.561967e-01 0.183 0 0
Formation of apoptosome R-HSA-111458 6.561967e-01 0.183 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.609860e-01 0.180 0 0
Signaling by FGFR in disease R-HSA-1226099 6.643597e-01 0.178 0 0
Signaling by ERBB4 R-HSA-1236394 6.643597e-01 0.178 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.680884e-01 0.175 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.680884e-01 0.175 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.680884e-01 0.175 0 0
LDL clearance R-HSA-8964038 6.691072e-01 0.175 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.691072e-01 0.175 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.691072e-01 0.175 0 0
Circadian clock R-HSA-9909396 6.693410e-01 0.174 0 0
PERK regulates gene expression R-HSA-381042 6.697953e-01 0.174 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.755402e-01 0.170 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.833160e-01 0.165 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.833160e-01 0.165 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.833160e-01 0.165 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.833160e-01 0.165 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.833160e-01 0.165 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.833160e-01 0.165 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.833160e-01 0.165 0 0
Signaling by APC mutants R-HSA-4839744 6.833160e-01 0.165 0 0
Chylomicron assembly R-HSA-8963888 6.833160e-01 0.165 0 0
LGI-ADAM interactions R-HSA-5682910 6.833160e-01 0.165 0 0
Suppression of apoptosis R-HSA-9635465 6.833160e-01 0.165 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.833160e-01 0.165 0 0
Prostanoid ligand receptors R-HSA-391908 6.833160e-01 0.165 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.833160e-01 0.165 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.833160e-01 0.165 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.850667e-01 0.164 0 0
UCH proteinases R-HSA-5689603 6.864785e-01 0.163 0 0
DNA Damage Bypass R-HSA-73893 6.875504e-01 0.163 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.876289e-01 0.163 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.876289e-01 0.163 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.876289e-01 0.163 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.876289e-01 0.163 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.919537e-01 0.160 0 0
Translation of Structural Proteins R-HSA-9694635 6.971720e-01 0.157 0 0
Selenocysteine synthesis R-HSA-2408557 6.992774e-01 0.155 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.998039e-01 0.155 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.003918e-01 0.155 0 0
Neurotransmitter release cycle R-HSA-112310 7.027310e-01 0.153 0 0
Ion transport by P-type ATPases R-HSA-936837 7.034370e-01 0.153 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.052892e-01 0.152 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.052892e-01 0.152 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.052892e-01 0.152 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.052892e-01 0.152 0 0
ABC transporter disorders R-HSA-5619084 7.076190e-01 0.150 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.082977e-01 0.150 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.082977e-01 0.150 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.082977e-01 0.150 0 0
Signaling by AXIN mutants R-HSA-4839735 7.082977e-01 0.150 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.082977e-01 0.150 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.082977e-01 0.150 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.082977e-01 0.150 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.082977e-01 0.150 0 0
The phototransduction cascade R-HSA-2514856 7.128486e-01 0.147 1 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.128486e-01 0.147 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.140104e-01 0.146 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.140104e-01 0.146 0 0
Cellular response to hypoxia R-HSA-1234174 7.146189e-01 0.146 0 0
Viral mRNA Translation R-HSA-192823 7.173439e-01 0.144 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.221086e-01 0.141 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.221086e-01 0.141 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.221086e-01 0.141 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.221086e-01 0.141 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.249216e-01 0.140 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.276915e-01 0.138 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.313100e-01 0.136 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.313100e-01 0.136 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.313100e-01 0.136 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.313100e-01 0.136 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.313100e-01 0.136 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.313100e-01 0.136 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.313100e-01 0.136 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.313100e-01 0.136 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.313100e-01 0.136 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.313100e-01 0.136 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.313100e-01 0.136 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.313100e-01 0.136 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.313100e-01 0.136 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.313100e-01 0.136 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.313100e-01 0.136 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.313100e-01 0.136 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.313100e-01 0.136 0 0
Interleukin-35 Signalling R-HSA-8984722 7.313100e-01 0.136 0 0
OAS antiviral response R-HSA-8983711 7.313100e-01 0.136 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.376016e-01 0.132 0 0
Interleukin-1 family signaling R-HSA-446652 7.376016e-01 0.132 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.381100e-01 0.132 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.381100e-01 0.132 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.381100e-01 0.132 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.381100e-01 0.132 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.381100e-01 0.132 0 0
TRP channels R-HSA-3295583 7.381100e-01 0.132 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.408538e-01 0.130 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.408538e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.408538e-01 0.130 0 0
Diseases of Immune System R-HSA-5260271 7.408538e-01 0.130 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.408538e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.408538e-01 0.130 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.420000e-01 0.130 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.430634e-01 0.129 0 0
Protein localization R-HSA-9609507 7.445520e-01 0.128 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.469215e-01 0.127 0 0
Adaptive Immune System R-HSA-1280218 7.471048e-01 0.127 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.479243e-01 0.126 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.525082e-01 0.123 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.525082e-01 0.123 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 7.525082e-01 0.123 0 0
Formation of axial mesoderm R-HSA-9796292 7.525082e-01 0.123 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.525082e-01 0.123 0 0
Frs2-mediated activation R-HSA-170968 7.525082e-01 0.123 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.525082e-01 0.123 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.525082e-01 0.123 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.525082e-01 0.123 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.525082e-01 0.123 0 0
Interconversion of polyamines R-HSA-351200 7.525082e-01 0.123 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.525082e-01 0.123 0 0
Maturation of nucleoprotein R-HSA-9683610 7.525082e-01 0.123 0 0
Interleukin-6 signaling R-HSA-1059683 7.525082e-01 0.123 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.525082e-01 0.123 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.533176e-01 0.123 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.533176e-01 0.123 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.533176e-01 0.123 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.533176e-01 0.123 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.533176e-01 0.123 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.533176e-01 0.123 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.533176e-01 0.123 0 0
Insulin processing R-HSA-264876 7.533176e-01 0.123 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.533176e-01 0.123 0 0
FLT3 Signaling R-HSA-9607240 7.535051e-01 0.123 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.535051e-01 0.123 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.542780e-01 0.122 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.572810e-01 0.121 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.592830e-01 0.120 0 0
Cardiac conduction R-HSA-5576891 7.647222e-01 0.116 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.656545e-01 0.116 0 0
HIV Transcription Initiation R-HSA-167161 7.656545e-01 0.116 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.656545e-01 0.116 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.656545e-01 0.116 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.656545e-01 0.116 0 0
Translation of Structural Proteins R-HSA-9683701 7.656545e-01 0.116 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.656545e-01 0.116 0 0
Telomere Extension By Telomerase R-HSA-171319 7.677571e-01 0.115 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.677571e-01 0.115 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.677571e-01 0.115 0 0
Inflammasomes R-HSA-622312 7.677571e-01 0.115 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.677571e-01 0.115 0 0
Removal of the Flap Intermediate R-HSA-69166 7.720351e-01 0.112 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.720351e-01 0.112 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.720351e-01 0.112 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.720351e-01 0.112 0 0
Hydrolysis of LPC R-HSA-1483115 7.720351e-01 0.112 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.720351e-01 0.112 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.720351e-01 0.112 0 0
Physiological factors R-HSA-5578768 7.720351e-01 0.112 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.720351e-01 0.112 0 0
Regulation of KIT signaling R-HSA-1433559 7.720351e-01 0.112 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.720351e-01 0.112 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.720351e-01 0.112 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.764299e-01 0.110 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.773119e-01 0.109 0 0
Cellular response to starvation R-HSA-9711097 7.774494e-01 0.109 0 0
DNA methylation R-HSA-5334118 7.814550e-01 0.107 0 0
mRNA Capping R-HSA-72086 7.814550e-01 0.107 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.814550e-01 0.107 0 0
Telomere Maintenance R-HSA-157579 7.816970e-01 0.107 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.822246e-01 0.107 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.822246e-01 0.107 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.884881e-01 0.103 0 0
Defective pyroptosis R-HSA-9710421 7.884881e-01 0.103 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.884881e-01 0.103 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.900224e-01 0.102 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.900224e-01 0.102 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.900224e-01 0.102 0 0
G beta:gamma signalling through BTK R-HSA-8964315 7.900224e-01 0.102 0 0
Translesion synthesis by REV1 R-HSA-110312 7.900224e-01 0.102 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.900224e-01 0.102 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.900224e-01 0.102 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.900224e-01 0.102 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 7.900224e-01 0.102 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.900224e-01 0.102 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.904831e-01 0.102 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.916012e-01 0.101 0 0
Ca2+ pathway R-HSA-4086398 7.933061e-01 0.101 0 0
Neurotransmitter clearance R-HSA-112311 7.944384e-01 0.100 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.944384e-01 0.100 0 0
Interleukin-37 signaling R-HSA-9008059 7.944384e-01 0.100 0 0
Netrin-1 signaling R-HSA-373752 7.991944e-01 0.097 0 0
Gastrulation R-HSA-9758941 8.056900e-01 0.094 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.065915e-01 0.093 0 0
Translesion synthesis by POLI R-HSA-5656121 8.065915e-01 0.093 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.065915e-01 0.093 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.065915e-01 0.093 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.065915e-01 0.093 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.065915e-01 0.093 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.065915e-01 0.093 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.065915e-01 0.093 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.065915e-01 0.093 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.065915e-01 0.093 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.065915e-01 0.093 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.067347e-01 0.093 0 0
Cargo concentration in the ER R-HSA-5694530 8.067347e-01 0.093 0 0
Downstream signal transduction R-HSA-186763 8.067347e-01 0.093 0 0
tRNA Aminoacylation R-HSA-379724 8.080785e-01 0.093 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.080785e-01 0.093 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.094428e-01 0.092 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.094428e-01 0.092 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.105672e-01 0.091 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.168719e-01 0.088 0 0
Aquaporin-mediated transport R-HSA-445717 8.168719e-01 0.088 0 0
Signaling by NOTCH1 R-HSA-1980143 8.180394e-01 0.087 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.182465e-01 0.087 0 0
Signaling by WNT in cancer R-HSA-4791275 8.183715e-01 0.087 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.183715e-01 0.087 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.192458e-01 0.087 0 0
Diseases of DNA repair R-HSA-9675135 8.192458e-01 0.087 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.192458e-01 0.087 0 0
Base Excision Repair R-HSA-73884 8.210119e-01 0.086 0 0
Translesion synthesis by POLK R-HSA-5655862 8.218540e-01 0.085 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.218540e-01 0.085 0 0
Passive transport by Aquaporins R-HSA-432047 8.218540e-01 0.085 0 0
Synthesis of PG R-HSA-1483148 8.218540e-01 0.085 0 0
Coenzyme A biosynthesis R-HSA-196783 8.218540e-01 0.085 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.218540e-01 0.085 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.218540e-01 0.085 0 0
Heme signaling R-HSA-9707616 8.253312e-01 0.083 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.253312e-01 0.083 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.334643e-01 0.079 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.359129e-01 0.078 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.359129e-01 0.078 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.359129e-01 0.078 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.359129e-01 0.078 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.359129e-01 0.078 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.359129e-01 0.078 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.359129e-01 0.078 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.359129e-01 0.078 0 0
GPER1 signaling R-HSA-9634597 8.375666e-01 0.077 0 0
NGF-stimulated transcription R-HSA-9031628 8.375666e-01 0.077 0 0
Co-stimulation by CD28 R-HSA-389356 8.375666e-01 0.077 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.377798e-01 0.077 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.377798e-01 0.077 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.382097e-01 0.077 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.397762e-01 0.076 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.397762e-01 0.076 0 0
Heme degradation R-HSA-189483 8.397762e-01 0.076 0 0
IGF1R signaling cascade R-HSA-2428924 8.412788e-01 0.075 0 0
Mitochondrial biogenesis R-HSA-1592230 8.413251e-01 0.075 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.415106e-01 0.075 0 0
Immune System R-HSA-168256 8.418798e-01 0.075 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.461107e-01 0.073 0 0
Signaling by MET R-HSA-6806834 8.472506e-01 0.072 0 0
Post-translational protein modification R-HSA-597592 8.481622e-01 0.072 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.487827e-01 0.071 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.488631e-01 0.071 0 0
Polo-like kinase mediated events R-HSA-156711 8.488631e-01 0.071 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.488631e-01 0.071 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.488631e-01 0.071 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.488631e-01 0.071 0 0
Platelet sensitization by LDL R-HSA-432142 8.488631e-01 0.071 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.488631e-01 0.071 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.488631e-01 0.071 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.495983e-01 0.071 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.495983e-01 0.071 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.495983e-01 0.071 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.495983e-01 0.071 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.495983e-01 0.071 0 0
Mitophagy R-HSA-5205647 8.495983e-01 0.071 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.495983e-01 0.071 0 0
Signaling by NOTCH2 R-HSA-1980145 8.495983e-01 0.071 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.495983e-01 0.071 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.525685e-01 0.069 0 0
Mitochondrial protein degradation R-HSA-9837999 8.540899e-01 0.068 0 0
PI3K Cascade R-HSA-109704 8.542616e-01 0.068 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.588689e-01 0.066 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.588689e-01 0.066 0 0
Signalling to ERKs R-HSA-187687 8.588689e-01 0.066 0 0
Regulation of signaling by CBL R-HSA-912631 8.607920e-01 0.065 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.607920e-01 0.065 0 0
Translesion Synthesis by POLH R-HSA-110320 8.607920e-01 0.065 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.607920e-01 0.065 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.607920e-01 0.065 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.607920e-01 0.065 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.607920e-01 0.065 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.607920e-01 0.065 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.607920e-01 0.065 0 0
Specification of the neural plate border R-HSA-9834899 8.607920e-01 0.065 0 0
Diseases of hemostasis R-HSA-9671793 8.607920e-01 0.065 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.607920e-01 0.065 0 0
Amine Oxidase reactions R-HSA-140179 8.607920e-01 0.065 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.607920e-01 0.065 0 0
Other interleukin signaling R-HSA-449836 8.607920e-01 0.065 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.607920e-01 0.065 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.628920e-01 0.064 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.676138e-01 0.062 0 0
G1/S-Specific Transcription R-HSA-69205 8.676138e-01 0.062 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.694373e-01 0.061 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.694373e-01 0.061 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.717800e-01 0.060 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.717800e-01 0.060 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.717800e-01 0.060 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.717800e-01 0.060 0 0
Creatine metabolism R-HSA-71288 8.717800e-01 0.060 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.717800e-01 0.060 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.717800e-01 0.060 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.730767e-01 0.059 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.758583e-01 0.058 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.758583e-01 0.058 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.758583e-01 0.058 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.764886e-01 0.057 0 0
Generic Transcription Pathway R-HSA-212436 8.801707e-01 0.055 0 0
G-protein activation R-HSA-202040 8.819013e-01 0.055 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.819013e-01 0.055 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.819013e-01 0.055 0 0
ERK/MAPK targets R-HSA-198753 8.819013e-01 0.055 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.819013e-01 0.055 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.819789e-01 0.055 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.819789e-01 0.055 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.819789e-01 0.055 0 0
MET promotes cell motility R-HSA-8875878 8.836268e-01 0.054 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.836268e-01 0.054 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.836268e-01 0.054 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.909431e-01 0.050 0 0
RAS processing R-HSA-9648002 8.909431e-01 0.050 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.909431e-01 0.050 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.912242e-01 0.050 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.912242e-01 0.050 0 0
Assembly Of The HIV Virion R-HSA-175474 8.912242e-01 0.050 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.933148e-01 0.049 0 0
TNF signaling R-HSA-75893 8.956540e-01 0.048 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.956540e-01 0.048 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.978301e-01 0.047 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.978301e-01 0.047 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.995221e-01 0.046 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.998116e-01 0.046 0 0
FGFR2 alternative splicing R-HSA-6803529 8.998116e-01 0.046 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.998116e-01 0.046 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.000501e-01 0.046 0 0
PI Metabolism R-HSA-1483255 9.009246e-01 0.045 0 0
IRS-mediated signalling R-HSA-112399 9.014222e-01 0.045 0 0
Cellular response to chemical stress R-HSA-9711123 9.033350e-01 0.044 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.043100e-01 0.044 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.043100e-01 0.044 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.072223e-01 0.042 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.073855e-01 0.042 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.077216e-01 0.042 0 0
Carnitine shuttle R-HSA-200425 9.077216e-01 0.042 0 0
Syndecan interactions R-HSA-3000170 9.077216e-01 0.042 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.091473e-01 0.041 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.104042e-01 0.041 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.104042e-01 0.041 0 0
Regulation of beta-cell development R-HSA-186712 9.121026e-01 0.040 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.121026e-01 0.040 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.124314e-01 0.040 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.150075e-01 0.039 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.150075e-01 0.039 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.150075e-01 0.039 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.150075e-01 0.039 0 0
Interleukin-6 family signaling R-HSA-6783589 9.150075e-01 0.039 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.161330e-01 0.038 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.188551e-01 0.037 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.188551e-01 0.037 0 0
Platelet homeostasis R-HSA-418346 9.208819e-01 0.036 0 0
Signaling by FGFR4 R-HSA-5654743 9.215163e-01 0.035 0 0
Signaling by SCF-KIT R-HSA-1433557 9.215163e-01 0.035 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.217185e-01 0.035 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.217185e-01 0.035 0 0
G protein gated Potassium channels R-HSA-1296059 9.217185e-01 0.035 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.217185e-01 0.035 0 0
Tight junction interactions R-HSA-420029 9.217185e-01 0.035 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.217185e-01 0.035 0 0
Hyaluronan degradation R-HSA-2160916 9.217185e-01 0.035 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.217185e-01 0.035 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.224584e-01 0.035 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.258998e-01 0.033 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.261595e-01 0.033 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.261595e-01 0.033 0 0
Signaling by PDGF R-HSA-186797 9.261595e-01 0.033 0 0
Signaling by NTRKs R-HSA-166520 9.267169e-01 0.033 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.278230e-01 0.033 0 0
MET activates PTK2 signaling R-HSA-8874081 9.279000e-01 0.032 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.279000e-01 0.032 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.279000e-01 0.032 0 0
Abacavir ADME R-HSA-2161522 9.279000e-01 0.032 0 0
Sphingolipid catabolism R-HSA-9845614 9.279000e-01 0.032 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.279384e-01 0.032 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.287531e-01 0.032 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.287531e-01 0.032 0 0
Neddylation R-HSA-8951664 9.293125e-01 0.032 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.310881e-01 0.031 0 0
Signaling by FGFR3 R-HSA-5654741 9.313205e-01 0.031 0 0
Amyloid fiber formation R-HSA-977225 9.334014e-01 0.030 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.334014e-01 0.030 0 0
Packaging Of Telomere Ends R-HSA-171306 9.335938e-01 0.030 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.335938e-01 0.030 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.335938e-01 0.030 0 0
Triglyceride biosynthesis R-HSA-75109 9.335938e-01 0.030 0 0
Synthesis of PE R-HSA-1483213 9.335938e-01 0.030 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.335938e-01 0.030 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.335938e-01 0.030 0 0
Insulin receptor signalling cascade R-HSA-74751 9.343519e-01 0.029 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.357767e-01 0.029 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.357767e-01 0.029 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.357767e-01 0.029 0 0
SLC transporter disorders R-HSA-5619102 9.370783e-01 0.028 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.388382e-01 0.027 0 0
Insulin receptor recycling R-HSA-77387 9.388382e-01 0.027 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.388382e-01 0.027 0 0
Prednisone ADME R-HSA-9757110 9.388382e-01 0.027 0 0
Synthesis of PC R-HSA-1483191 9.399578e-01 0.027 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.402083e-01 0.027 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.402986e-01 0.027 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.402986e-01 0.027 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.402986e-01 0.027 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.428783e-01 0.026 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.428783e-01 0.026 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.436687e-01 0.025 0 0
Thyroxine biosynthesis R-HSA-209968 9.436687e-01 0.025 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.436687e-01 0.025 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.436687e-01 0.025 0 0
Signaling by Erythropoietin R-HSA-9006335 9.436687e-01 0.025 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.436687e-01 0.025 0 0
Glucagon-type ligand receptors R-HSA-420092 9.436687e-01 0.025 0 0
DAP12 signaling R-HSA-2424491 9.481180e-01 0.023 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.481180e-01 0.023 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.481180e-01 0.023 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.481180e-01 0.023 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.481180e-01 0.023 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.492357e-01 0.023 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.505018e-01 0.022 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.510030e-01 0.022 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.512407e-01 0.022 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.522161e-01 0.021 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.522161e-01 0.021 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.542106e-01 0.020 0 0
Meiotic recombination R-HSA-912446 9.542326e-01 0.020 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.559907e-01 0.020 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.559907e-01 0.020 0 0
Toll-like Receptor Cascades R-HSA-168898 9.571173e-01 0.019 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.594673e-01 0.018 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.594673e-01 0.018 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.594673e-01 0.018 0 0
Selenoamino acid metabolism R-HSA-2408522 9.621845e-01 0.017 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.626695e-01 0.017 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.626695e-01 0.017 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.626695e-01 0.017 0 0
G alpha (z) signalling events R-HSA-418597 9.652266e-01 0.015 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.656189e-01 0.015 0 0
Hyaluronan metabolism R-HSA-2142845 9.656189e-01 0.015 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.656189e-01 0.015 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.656189e-01 0.015 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.656189e-01 0.015 0 0
Integration of energy metabolism R-HSA-163685 9.672089e-01 0.014 0 0
Signaling by Insulin receptor R-HSA-74752 9.675377e-01 0.014 0 0
Signaling by FGFR1 R-HSA-5654736 9.675498e-01 0.014 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.675498e-01 0.014 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.683355e-01 0.014 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.683355e-01 0.014 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.683355e-01 0.014 0 0
Oncogene Induced Senescence R-HSA-2559585 9.683355e-01 0.014 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.683355e-01 0.014 0 0
RUNX2 regulates bone development R-HSA-8941326 9.708375e-01 0.013 0 0
RET signaling R-HSA-8853659 9.708375e-01 0.013 0 0
Triglyceride catabolism R-HSA-163560 9.708375e-01 0.013 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.708375e-01 0.013 0 0
GPVI-mediated activation cascade R-HSA-114604 9.708375e-01 0.013 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.717559e-01 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.717559e-01 0.012 0 0
Infectious disease R-HSA-5663205 9.719502e-01 0.012 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.729212e-01 0.012 0 0
Parasite infection R-HSA-9664407 9.729212e-01 0.012 0 0
Leishmania phagocytosis R-HSA-9664417 9.729212e-01 0.012 0 0
Cleavage of the damaged purine R-HSA-110331 9.731420e-01 0.012 0 0
Metabolism of folate and pterines R-HSA-196757 9.731420e-01 0.012 0 0
Peroxisomal protein import R-HSA-9033241 9.736566e-01 0.012 0 0
Triglyceride metabolism R-HSA-8979227 9.736566e-01 0.012 0 0
Metabolism of proteins R-HSA-392499 9.741833e-01 0.011 0 0
Elastic fibre formation R-HSA-1566948 9.752645e-01 0.011 0 0
Depurination R-HSA-73927 9.752645e-01 0.011 0 0
Signaling by FGFR2 R-HSA-5654738 9.752673e-01 0.011 0 0
Interferon gamma signaling R-HSA-877300 9.770272e-01 0.010 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.772193e-01 0.010 0 0
Pentose phosphate pathway R-HSA-71336 9.772193e-01 0.010 0 0
Regulation of insulin secretion R-HSA-422356 9.783000e-01 0.010 0 0
Glycogen metabolism R-HSA-8982491 9.790198e-01 0.009 0 0
Tryptophan catabolism R-HSA-71240 9.790198e-01 0.009 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.795291e-01 0.009 0 0
Adipogenesis R-HSA-9843745 9.809044e-01 0.008 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.814496e-01 0.008 0 0
Rab regulation of trafficking R-HSA-9007101 9.825166e-01 0.008 0 0
Activation of GABAB receptors R-HSA-991365 9.836121e-01 0.007 0 0
GABA B receptor activation R-HSA-977444 9.836121e-01 0.007 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.836121e-01 0.007 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.836121e-01 0.007 0 0
Depyrimidination R-HSA-73928 9.836121e-01 0.007 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.841327e-01 0.007 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.849076e-01 0.007 0 0
TBC/RABGAPs R-HSA-8854214 9.849076e-01 0.007 0 0
Pyruvate metabolism R-HSA-70268 9.851182e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.856331e-01 0.006 0 0
G1 Phase R-HSA-69236 9.861008e-01 0.006 0 0
Cyclin D associated events in G1 R-HSA-69231 9.861008e-01 0.006 0 0
DAP12 interactions R-HSA-2172127 9.861008e-01 0.006 0 0
Surfactant metabolism R-HSA-5683826 9.861008e-01 0.006 0 0
Amine ligand-binding receptors R-HSA-375280 9.861008e-01 0.006 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.868628e-01 0.006 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.874924e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.878804e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.878804e-01 0.005 0 0
Ion channel transport R-HSA-983712 9.883391e-01 0.005 0 0
Stimuli-sensing channels R-HSA-2672351 9.886941e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.887156e-01 0.005 0 0
Metabolism of porphyrins R-HSA-189445 9.887156e-01 0.005 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.894947e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.899062e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.900025e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.902211e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.905438e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.907931e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.914200e-01 0.004 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.915213e-01 0.004 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.921919e-01 0.003 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.926668e-01 0.003 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.927270e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.927270e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.931778e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.931778e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.935524e-01 0.003 0 0
Signaling by FGFR R-HSA-190236 9.936271e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.939021e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.940357e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.942280e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.943845e-01 0.002 0 0
tRNA processing R-HSA-72306 9.947100e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.948288e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.952379e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.952379e-01 0.002 0 0
HCMV Late Events R-HSA-9610379 9.958336e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.959617e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.962813e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.962813e-01 0.002 0 0
Disease R-HSA-1643685 9.965475e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.965514e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.965514e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.965756e-01 0.001 0 0
MAP kinase activation R-HSA-450294 9.965756e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.969150e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.970962e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.973338e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.973570e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.975337e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.979122e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.980255e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.980775e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.980775e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.981722e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.981976e-01 0.001 0 0
Interleukin-17 signaling R-HSA-448424 9.983699e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.984358e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.984358e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.984989e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.984989e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.985364e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.986178e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.987384e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.988281e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.989058e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.991112e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.991309e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.991576e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.991583e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.992531e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.992777e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.993473e-01 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.994647e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.994856e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.994866e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995895e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.997186e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997186e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997186e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997813e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997931e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998513e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998781e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999071e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999257e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.999356e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999436e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999604e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999613e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999721e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999870e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999876e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999878e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999900e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.999903e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999930e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999946e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999970e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999978e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999985e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999990e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999994e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999996e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways