MOK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00116	T68	Sugiyama	AGPS AAG5	RPREALSTNECKARRAAsAAtAAPtAtPAAQEsGtIPKKRQ
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00488	S40	Sugiyama	ZNF593 ZT86	KAKRRRPDLDEIHRELRPQGsARPQPDPNAEFDPDLPGGGL
O14579	S307	Sugiyama	COPE	IKEYQAKENDFDRLVLQyAPsA___________________
O14641	S648	Sugiyama	DVL2	GGSLRRGGEAsGtsDGGPPPsRGstGGAPNLRAHPGLHPYG
O14908	S232	Sugiyama	GIPC1 C19orf3 GIPC RGS19IP1	TEPRKAFDMISQRsAGGRPGsGPQLGtGRGtLRLRsRGPAt
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S196	Sugiyama	EIF5B IF2 KIAA0741	ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O75122	S22	Sugiyama	CLASP2 KIAA0627	AMGDDKsFDDEEsVDGNRPssAAsAFKVPAPKTSGNPANSA
O75822	T33	Sugiyama	EIF3J EIF3S1 PRO0391	sWDADAFsVEDPVRKVGGGGtAGGDRWEGEDEDEDVKDNWD
O94804	S450	Sugiyama	STK10 LOK	VAEQGGDLsPAANRsQKAsQsRPNssALEtLGGEKLANGsL
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733	S14	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	_______MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAA
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08865	T97	Sugiyama	RPSA LAMBR LAMR1	IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P11142	T222	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFI
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P12270	T650	Sugiyama	TPR	AssLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEAKA
P12277	S147	Sugiyama	CKB CKBB	LssRVRTGRSIRGFCLPPHCsRGERRAIEKLAVEALssLDG
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13929	S14	Sugiyama	ENO3	_______MAMQKIFAREILDsRGNPtVEVDLHtAKGRFRAA
P13929	T26	Sugiyama	ENO3	IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P14618	S37	Sugiyama	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618	S55	Sugiyama	PKM OIP3 PK2 PK3 PKM2	IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626	S341	Sugiyama	HNRNPA2B1 HNRPA2B1	FGGsRNMGGPyGGGNyGPGGsGGsGGyGGRsRy________
P22626	S344	Sugiyama	HNRNPA2B1 HNRPA2B1	sRNMGGPyGGGNyGPGGsGGsGGyGGRsRy___________
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	T205	Sugiyama	EIF4B	GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P23921	S780	Sugiyama	RRM1 RR1	KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P27695	S135	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	SHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEG
P28066	S172	Sugiyama	PSMA5	QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK
P30050	T135	Sugiyama	RPL12	QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P34897	T420	Sugiyama	SHMT2	LELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFREDD
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P35250	S30	Sugiyama	RFC2	AGEVEAQDSDPAPAFSKAPGsAGHyELPWVEKYRPVKLNEI
P35579	S1892	Sugiyama	MYH9	LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35613	S278	Sugiyama	BSG UNQ6505/PRO21383	ITDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQ
P35998	T193	Sugiyama	PSMC2 MSS1	TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P42166	S158	Sugiyama	TMPO LAP2	tRKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsN
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	S158	Sugiyama	TMPO LAP2	TRKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSN
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42679	S484	Sugiyama	MATK CTK HYL	EPARRPPFRKLAEKLARELRsAGAPASVsGQDADGstsPRs
P42765	T227	Sugiyama	ACAA2	EVKTKKGKQTMQVDEHARPQtTLEQLQKLPPVFKKDGTVTA
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46013	S299	Sugiyama	MKI67	GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P47914	S142	Sugiyama	RPL29	KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P50502	S181	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P51991	S358	Sugiyama	HNRNPA3 HNRPA3	QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P54259	S101	Sugiyama	ATN1 D12S755E DRPLA	sEETNAPKKTKtEQELPRPQsPsDLDsLDGRsLNDDGSsDP
P54652	T225	Sugiyama	HSPA2	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLA
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P60174	T46	Sugiyama	TPI1 TPI	IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353	S39	Sugiyama	RPL27	SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P62195	T194	Sugiyama	PSMC5 SUG1	LFEALGIAQPKGVLLyGPPGtGKTLLARAVAHHTDCTFIRV
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62995	T201	Sugiyama	TRA2B SFRS10	GMELDGRRIRVDFSITKRPHtPtPGIyMGRPtYGssRRRDY
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P68431	T46	Sugiyama	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84243	T46	Sugiyama	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q00059	S160	Sugiyama	TFAM TCF6 TCF6L2	RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01518	S301	Sugiyama	CAP1 CAP	HKNPALKAQSGPVRsGPKPFsAPKPQtsPsPKRATKKEPAV
Q01518	T307	Sugiyama	CAP1 CAP	KAQSGPVRsGPKPFsAPKPQtsPsPKRATKKEPAVLELEGK
Q02543	T102	Sugiyama	RPL18A	LRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAH
Q02543	T24	Sugiyama	RPL18A	SGTLREYKVVGRCLPTPKCHtPPLYRMRIFAPNHVVAKSRF
Q08J23	S383	Sugiyama	NSUN2 SAKI TRM4	QWKVMTKDGQWFTDWDAVPHsRHTQIRPTMFPPKDPEKLQA
Q12789	S846	Sugiyama	GTF3C1	ISERRTIKQESGRAGVRPsssGsAWEACSEAPSKGSQDGVT
Q13263	T415	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	LNAWTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQ
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14103	T193	Sugiyama	HNRNPD AUF1 HNRPD	KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14135	S200	Sugiyama	VGLL4 KIAA0121	CPIAHSGCAAPGPASYRRPPsAAttCDPVVEEHFRRSLGKN
Q14135	T204	Sugiyama	VGLL4 KIAA0121	HSGCAAPGPASYRRPPsAAttCDPVVEEHFRRSLGKNYKEP
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14980	S1862	Sugiyama	NUMA1 NMP22 NUMA	PAsQAsLRAtsstQsLARLGsPDYGNsALLsLPGyRPttRs
Q14980	T2000	Sugiyama	NUMA1 NMP22 NUMA	GITTRQQRKRVsLEPHQGPGtPEsKKATSCFPRPMtPRDRH
Q15084	S230	Sugiyama	PDIA6 ERP5 P5 TXNDC7	QTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIFQKGEsPV
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15637	S89	Sugiyama	SF1 ZFM1 ZNF162	DLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTRKKLEEER
Q15773	S240	Sugiyama	MLF2	GGRRAEGPPRLAIQGPEDsPsRQsRRYDW____________
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16543	T370	Sugiyama	CDC37 CDC37A	EAKEGEEAGPGDPLLEAVPKtGDEKDVsV____________
Q16695	T46	Sugiyama	H3-4 H3FT HIST3H3	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5TDH0	T104	Sugiyama	DDI2	PPVQFPNLPRIDFsSIAVPGtssPRQRQPPGtQQsHssPGE
Q6GYQ0	T1002	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6NXT2	T45	Sugiyama	H3-5 H3F3C	AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PKG0	T769	Sugiyama	LARP1 KIAA0731 LARP	ALANKLFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtP
Q6QNY0	T16	Sugiyama	BLOC1S3 BLOS3	_____MASQGRRRRPLRRPEtVVPGEAtEtDsERsAsssEE
Q6XQN6	S513	Sugiyama	NAPRT FHIP NAPRT1	SRALAQLsLSRLSPEHRRLRsPAQYQVVLSERLQALVNSLC
Q71DI3	T46	Sugiyama	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q71RC2	S597	Sugiyama	LARP4 PP13296	QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q86V81	T148	Sugiyama	ALYREF ALY BEF THOC4	EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86X29	S365	Sugiyama	LSR ILDR3 LISCH	MGPAYNGYPGGYPGDVDRsssAGGQGsyVPLLRDTDssVAs
Q8IWS0	S346	Sugiyama	PHF6 CENP-31 KIAA1823	CKNHSGNDERDEEDEERESKsRGKVEIDQQQLtQQQLNGN_
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N1G4	T27	Sugiyama	LRRC47 KIAA1185	SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ7	T260	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8NBP7	S488	Sugiyama	PCSK9 NARC1 PSEC0052	TRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKLV
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NFI4	S181	Sugiyama	ST13P5 FAM10A5	LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8WZA9	S44	Sugiyama	IRGQ IRGQ1 FKSG27	IAALCDKDVEtLEAPEGRPDsGVPSLRAAGPGLFLGELSCP
Q96EP5	S204	Sugiyama	DAZAP1	EVKRAEPRDsKsQAPGQPGAsQWGsRVVPNAANGWAGQPPP
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96QR8	S23	Sugiyama	PURB	DGDsGsERGGGGGPCGFQPAsRGGGEQEtQELASKRLDIQN
Q9BQ52	S796	Sugiyama	ELAC2 HPC2	EEMEERREKRELRQVRAALLsRELAGGLEDGEPQQKRAHTE
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S983	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H4A3	S167	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	AVAGPAPSTVPSSTSKDRPVsQPsLVGsKEEPPPARsGsGG
Q9H7E2	S358	Sugiyama	TDRD3	RDSQNSKsVLEGSGLPRNRGsERPSTssVsEVWAEDRIKCD
Q9H7E2	S365	Sugiyama	TDRD3	sVLEGSGLPRNRGsERPSTssVsEVWAEDRIKCDRPYSRYD
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NTJ3	S22	Sugiyama	SMC4 CAPC SMC4L1	PRKGTQPSTARRREEGPPPPsPDGAssDAEPEPPsGRtEsP
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NY61	S61	Sugiyama	AATF CHE1 DED HSPC277	DEGEDGEGDFLVVGsIRKLAsAsLLDtDKRYCGKTTSRKAW
Q9NYM9	S9	Sugiyama	BET1L GS15	____________MADWARAQsPGAVEEILDRENKRMADSLA
Q9NZB2	T991	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UQ07	S315	Sugiyama	MOK RAGE RAGE1	ALGSHRKAGFPEHPVAPEPLsNsCQIsKEGRKQKQSLKQEE
Q9UQ07	S317	Sugiyama	MOK RAGE RAGE1	GSHRKAGFPEHPVAPEPLsNsCQIsKEGRKQKQSLKQEEDR
Q9UQ07	S321	Sugiyama	MOK RAGE RAGE1	KAGFPEHPVAPEPLsNsCQIsKEGRKQKQSLKQEEDRPKRR
Q9UQ07	S364	Sugiyama	MOK RAGE RAGE1	AYVMELPKLKLSGVVRLSSYssPTLQSVLGSGTNGRVPVLR
Q9UQ07	S365	Sugiyama	MOK RAGE RAGE1	YVMELPKLKLSGVVRLSSYssPTLQSVLGSGTNGRVPVLRP
Q9UQ07	S41	Sugiyama	MOK RAGE RAGE1	MQSLRDGNYYACKQMKQRFEsIEQVNNLREIQALRRLNPHP
Q9UQ07	T159	Sugiyama	MOK RAGE RAGE1	DVLKLGDFGSCRSVYSKQPYtEyISTRWYRAPECLLTDGFY
Q9UQ07	T220	Sugiyama	MOK RAGE RAGE1	PLFPGVNELDQISKIHDVIGtPAQKILTKFKQSRAMNFDFP
Q9UQ07	Y161	Sugiyama	MOK RAGE RAGE1	LKLGDFGSCRSVYSKQPYtEyISTRWYRAPECLLTDGFYTY
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2694	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9UQ35	S322	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RRGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDK
Q9UQ35	S323	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDKK
Q9UQ35	T328	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9Y262	T248	Sugiyama	EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005	LNVLHSLVDKSNINRQLEVytsGGDPEsVAGEyGRHSLYKM
Q9Y2V2	S41	Sugiyama	CARHSP1	LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2V2	T45	Sugiyama	CARHSP1	RsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKG

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
PKMTs methylate histone lysines	R-HSA-3214841	3.102953e-09	8.508
Chromatin organization	R-HSA-4839726	1.609431e-06	5.793
Cell Cycle	R-HSA-1640170	1.985915e-06	5.702
Chromatin modifying enzymes	R-HSA-3247509	3.659643e-06	5.437
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.383087e-05	4.859
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.995054e-05	4.700
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.396920e-05	4.357
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.343676e-05	4.272
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.348025e-05	4.197
Transcriptional Regulation by TP53	R-HSA-3700989	6.527762e-05	4.185
Signaling by NTRKs	R-HSA-166520	8.003297e-05	4.097
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.788094e-05	4.009
Cell Cycle Checkpoints	R-HSA-69620	1.176498e-04	3.929
Late Phase of HIV Life Cycle	R-HSA-162599	1.369369e-04	3.863
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.715242e-04	3.766
Cell Cycle, Mitotic	R-HSA-69278	1.752626e-04	3.756
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.701455e-04	3.769
Signal Transduction	R-HSA-162582	1.723474e-04	3.764
Regulation of TP53 Activity	R-HSA-5633007	2.044079e-04	3.690
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.264778e-04	3.645
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.264778e-04	3.645
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.446861e-04	3.611
Gene expression (Transcription)	R-HSA-74160	2.689401e-04	3.570
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.668911e-04	3.574
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.894249e-04	3.410
HIV Life Cycle	R-HSA-162587	4.256641e-04	3.371
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.462175e-04	3.263
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.462175e-04	3.263
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.636909e-04	3.178
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.070723e-04	3.151
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.310824e-04	3.136
HIV Transcription Initiation	R-HSA-167161	7.310824e-04	3.136
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.310824e-04	3.136
mRNA Splicing	R-HSA-72172	7.065085e-04	3.151
mRNA Splicing - Major Pathway	R-HSA-72163	8.472214e-04	3.072
RNA Polymerase II Promoter Escape	R-HSA-73776	9.640293e-04	3.016
Nuclear import of Rev protein	R-HSA-180746	9.712968e-04	3.013
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.253832e-03	2.902
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.365450e-03	2.865
Estrogen-dependent gene expression	R-HSA-9018519	1.492065e-03	2.826
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.595628e-03	2.797
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.022285e-03	2.694
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.984674e-03	2.702
Transcriptional regulation by small RNAs	R-HSA-5578749	2.027262e-03	2.693
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.352474e-03	2.628
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.352474e-03	2.628
RNA Polymerase II Transcription Termination	R-HSA-73856	2.194558e-03	2.659
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.094872e-03	2.679
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.266699e-03	2.645
Signaling by ALK in cancer	R-HSA-9700206	2.266699e-03	2.645
Interactions of Rev with host cellular proteins	R-HSA-177243	2.262327e-03	2.645
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.119144e-03	2.674
Mitotic Prophase	R-HSA-68875	2.567281e-03	2.591
Cellular response to heat stress	R-HSA-3371556	2.749390e-03	2.561
Epigenetic regulation of gene expression	R-HSA-212165	2.929445e-03	2.533
IGF1R signaling cascade	R-HSA-2428924	2.962305e-03	2.528
IPs transport between nucleus and cytosol	R-HSA-1855170	3.136066e-03	2.504
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.261136e-03	2.487
RNA Polymerase II Transcription	R-HSA-73857	3.215727e-03	2.493
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.595715e-03	2.444
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.841514e-03	2.415
Transcription of the HIV genome	R-HSA-167172	4.303689e-03	2.366
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.666816e-03	2.331
Activation of HOX genes during differentiation	R-HSA-5619507	4.753576e-03	2.323
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.753576e-03	2.323
Polo-like kinase mediated events	R-HSA-156711	5.476185e-03	2.262
RET signaling	R-HSA-8853659	5.284852e-03	2.277
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.962328e-03	2.225
Gene Silencing by RNA	R-HSA-211000	5.832111e-03	2.234
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.083642e-03	2.216
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.355697e-03	2.197
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.702608e-03	2.174
Viral Messenger RNA Synthesis	R-HSA-168325	6.939584e-03	2.159
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.509063e-03	2.124
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.165436e-03	2.145
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.509063e-03	2.124
SHC-related events triggered by IGF1R	R-HSA-2428933	7.869382e-03	2.104
HATs acetylate histones	R-HSA-3214847	7.963034e-03	2.099
M Phase	R-HSA-68886	8.064229e-03	2.093
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.869382e-03	2.104
Signaling by LTK	R-HSA-9842663	7.869382e-03	2.104
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.579943e-03	2.120
Interactions of Vpr with host cellular proteins	R-HSA-176033	8.385066e-03	2.076
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.540787e-03	2.069
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.540787e-03	2.069
mRNA 3'-end processing	R-HSA-72187	9.376717e-03	2.028
Cellular Senescence	R-HSA-2559583	8.982859e-03	2.047
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.333974e-03	2.030
HIV Infection	R-HSA-162906	9.732448e-03	2.012
DNA Double-Strand Break Repair	R-HSA-5693532	9.906506e-03	2.004
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.041916e-02	1.982
Diseases of mitotic cell cycle	R-HSA-9675126	1.091805e-02	1.962
Processing of DNA double-strand break ends	R-HSA-5693607	1.215558e-02	1.915
Signaling by FGFR2	R-HSA-5654738	1.131626e-02	1.946
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.215558e-02	1.915
G2/M Transition	R-HSA-69275	1.183895e-02	1.927
Signaling by EGFR	R-HSA-177929	1.335620e-02	1.874
Signaling by FGFR4	R-HSA-5654743	1.265131e-02	1.898
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.288556e-02	1.890
Homology Directed Repair	R-HSA-5693538	1.294503e-02	1.888
Mitotic G2-G2/M phases	R-HSA-453274	1.293640e-02	1.888
Generic Transcription Pathway	R-HSA-212436	1.259738e-02	1.900
NRAGE signals death through JNK	R-HSA-193648	1.335620e-02	1.874
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.385247e-02	1.858
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.444783e-02	1.840
ESR-mediated signaling	R-HSA-8939211	1.451371e-02	1.838
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.656543e-02	1.781
TRAF6 mediated NF-kB activation	R-HSA-933542	1.579461e-02	1.801
Regulation of TP53 Expression	R-HSA-6804754	1.622051e-02	1.790
Signaling by FGFR3	R-HSA-5654741	1.528743e-02	1.816
S Phase	R-HSA-69242	1.621914e-02	1.790
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.528743e-02	1.816
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.671770e-02	1.777
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.674227e-02	1.776
Signalling to ERKs	R-HSA-187687	1.700957e-02	1.769
snRNP Assembly	R-HSA-191859	1.706248e-02	1.768
Metabolism of non-coding RNA	R-HSA-194441	1.706248e-02	1.768
FLT3 signaling in disease	R-HSA-9682385	1.883633e-02	1.725
TGFBR3 expression	R-HSA-9839394	1.791019e-02	1.747
G2/M DNA damage checkpoint	R-HSA-69473	1.923790e-02	1.716
RUNX2 regulates bone development	R-HSA-8941326	1.883633e-02	1.725
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.821126e-02	1.740
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.940620e-02	1.712
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.940620e-02	1.712
NGF-stimulated transcription	R-HSA-9031628	1.994042e-02	1.700
Mitotic Spindle Checkpoint	R-HSA-69618	2.029439e-02	1.693
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.075166e-02	1.683
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.253020e-02	1.647
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.253020e-02	1.647
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.253020e-02	1.647
G2/M Checkpoints	R-HSA-69481	2.194854e-02	1.659
MAPK family signaling cascades	R-HSA-5683057	2.117595e-02	1.674
Glycolysis	R-HSA-70171	2.029439e-02	1.693
ISG15 antiviral mechanism	R-HSA-1169408	2.059625e-02	1.686
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.268364e-02	1.644
MET interacts with TNS proteins	R-HSA-8875513	2.456245e-02	1.610
Transcriptional Regulation by MECP2	R-HSA-8986944	2.475177e-02	1.606
G alpha (12/13) signalling events	R-HSA-416482	2.508458e-02	1.601
Transcriptional Regulation by E2F6	R-HSA-8953750	2.510829e-02	1.600
Signaling by ALK	R-HSA-201556	2.510829e-02	1.600
Signal attenuation	R-HSA-74749	2.549925e-02	1.593
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.965060e-02	1.528
Downstream signaling of activated FGFR3	R-HSA-5654708	2.821194e-02	1.550
Signaling by MET	R-HSA-6806834	2.843728e-02	1.546
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.848478e-02	1.545
Circadian clock	R-HSA-9909396	2.921984e-02	1.534
Signaling by TGFB family members	R-HSA-9006936	2.776704e-02	1.556
DNA Repair	R-HSA-73894	3.073761e-02	1.512
Activated NTRK3 signals through RAS	R-HSA-9034864	3.076285e-02	1.512
Downstream signaling of activated FGFR4	R-HSA-5654716	3.126925e-02	1.505
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.428292e-02	1.465
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.428292e-02	1.465
Drug resistance of FLT3 mutants	R-HSA-9702506	4.687095e-02	1.329
FLT3 mutants bind TKIs	R-HSA-9702509	4.687095e-02	1.329
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.687095e-02	1.329
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	4.687095e-02	1.329
linifanib-resistant FLT3 mutants	R-HSA-9702998	4.687095e-02	1.329
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	4.687095e-02	1.329
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	4.687095e-02	1.329
ponatinib-resistant FLT3 mutants	R-HSA-9702614	4.687095e-02	1.329
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	4.687095e-02	1.329
tamatinib-resistant FLT3 mutants	R-HSA-9703009	4.687095e-02	1.329
quizartinib-resistant FLT3 mutants	R-HSA-9702620	4.687095e-02	1.329
tandutinib-resistant FLT3 mutants	R-HSA-9702636	4.687095e-02	1.329
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	4.687095e-02	1.329
KW2449-resistant FLT3 mutants	R-HSA-9702569	4.687095e-02	1.329
midostaurin-resistant FLT3 mutants	R-HSA-9702600	4.687095e-02	1.329
semaxanib-resistant FLT3 mutants	R-HSA-9702577	4.687095e-02	1.329
sunitinib-resistant FLT3 mutants	R-HSA-9702632	4.687095e-02	1.329
sorafenib-resistant FLT3 mutants	R-HSA-9702624	4.687095e-02	1.329
crenolanib-resistant FLT3 mutants	R-HSA-9702581	4.687095e-02	1.329
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.523470e-02	1.345
FLT3 signaling by CBL mutants	R-HSA-9706377	4.523470e-02	1.345
Activated NTRK2 signals through RAS	R-HSA-9026519	3.655125e-02	1.437
Signaling by AXIN mutants	R-HSA-4839735	3.655125e-02	1.437
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.285637e-02	1.368
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.795954e-02	1.421
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.525536e-02	1.344
Interleukin-15 signaling	R-HSA-8983432	4.285637e-02	1.368
Cyclin E associated events during G1/S transition	R-HSA-69202	3.696108e-02	1.432
Signaling by FGFR	R-HSA-190236	4.050658e-02	1.392
Signaling by FGFR1	R-HSA-5654736	3.696671e-02	1.432
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.581332e-02	1.446
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.795954e-02	1.421
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.795954e-02	1.421
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.848267e-02	1.415
G1/S Transition	R-HSA-69206	4.100275e-02	1.387
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.285637e-02	1.368
Regulation of MECP2 expression and activity	R-HSA-9022692	4.165013e-02	1.380
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.165013e-02	1.380
Death Receptor Signaling	R-HSA-73887	4.152816e-02	1.382
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.285637e-02	1.368
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.256470e-02	1.371
Inositol phosphate metabolism	R-HSA-1483249	4.006294e-02	1.397
Nuclear Envelope Breakdown	R-HSA-2980766	3.960876e-02	1.402
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.839234e-02	1.416
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.433072e-02	1.353
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.747069e-02	1.324
Condensation of Prophase Chromosomes	R-HSA-2299718	4.816957e-02	1.317
Signaling by TGFBR3	R-HSA-9839373	4.816957e-02	1.317
Regulation of PTEN gene transcription	R-HSA-8943724	4.826262e-02	1.316
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.826262e-02	1.316
Signaling by ERBB2	R-HSA-1227986	4.826262e-02	1.316
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.826262e-02	1.316
RAF activation	R-HSA-5673000	4.959829e-02	1.305
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.966730e-02	1.304
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.966730e-02	1.304
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.966730e-02	1.304
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.966730e-02	1.304
IRS-related events triggered by IGF1R	R-HSA-2428928	5.139405e-02	1.289
Metabolism of RNA	R-HSA-8953854	5.139789e-02	1.289
Interleukin receptor SHC signaling	R-HSA-912526	5.267645e-02	1.278
IkBA variant leads to EDA-ID	R-HSA-5603029	5.728133e-02	1.242
Insulin receptor signalling cascade	R-HSA-74751	6.154213e-02	1.211
HDMs demethylate histones	R-HSA-3214842	6.397803e-02	1.194
Downstream signaling of activated FGFR2	R-HSA-5654696	5.388403e-02	1.269
Downstream signaling of activated FGFR1	R-HSA-5654687	5.388403e-02	1.269
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.817990e-02	1.235
Mitochondrial biogenesis	R-HSA-1592230	5.495676e-02	1.260
Signaling by FGFR4 in disease	R-HSA-5655291	5.697066e-02	1.244
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.465062e-02	1.262
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.734957e-02	1.241
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.864049e-02	1.232
G1/S-Specific Transcription	R-HSA-69205	5.837789e-02	1.234
Heme signaling	R-HSA-9707616	5.465062e-02	1.262
tRNA processing in the nucleus	R-HSA-6784531	5.465062e-02	1.262
Interleukin-7 signaling	R-HSA-1266695	6.397803e-02	1.194
Glucose metabolism	R-HSA-70326	5.495676e-02	1.260
Erythropoietin activates RAS	R-HSA-9027284	6.475100e-02	1.189
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	6.475100e-02	1.189
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.475100e-02	1.189
MITF-M-dependent gene expression	R-HSA-9856651	6.593176e-02	1.181
Organelle biogenesis and maintenance	R-HSA-1852241	6.670067e-02	1.176
HSF1-dependent transactivation	R-HSA-3371571	6.759876e-02	1.170
MET promotes cell motility	R-HSA-8875878	6.798821e-02	1.168
AURKA Activation by TPX2	R-HSA-8854518	6.894143e-02	1.162
G2/M DNA replication checkpoint	R-HSA-69478	7.029640e-02	1.153
SOS-mediated signalling	R-HSA-112412	8.416291e-02	1.075
Cohesin Loading onto Chromatin	R-HSA-2470946	8.416291e-02	1.075
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.416291e-02	1.075
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.299110e-02	1.137
Phosphorylation of the APC/C	R-HSA-176412	7.299110e-02	1.137
RNA Polymerase I Promoter Opening	R-HSA-73728	7.644184e-02	1.117
Attenuation phase	R-HSA-3371568	7.842113e-02	1.106
Amplification of signal from the kinetochores	R-HSA-141424	8.700115e-02	1.060
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.700115e-02	1.060
FLT3 Signaling	R-HSA-9607240	8.394162e-02	1.076
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.897742e-02	1.102
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.897742e-02	1.102
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.897742e-02	1.102
Oncogenic MAPK signaling	R-HSA-6802957	8.308423e-02	1.080
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.842113e-02	1.106
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.006693e-02	1.154
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.842113e-02	1.106
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.842113e-02	1.106
DNA Double Strand Break Response	R-HSA-5693606	7.283211e-02	1.138
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	7.006693e-02	1.154
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.394162e-02	1.076
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	8.167225e-02	1.088
Signaling by EGFR in Cancer	R-HSA-1643713	7.006693e-02	1.154
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.029640e-02	1.153
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.167225e-02	1.088
RAF/MAP kinase cascade	R-HSA-5673001	7.421300e-02	1.130
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.927350e-02	1.101
CHL1 interactions	R-HSA-447041	8.416291e-02	1.075
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	8.416291e-02	1.075
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.362447e-02	1.078
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.362447e-02	1.078
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.362447e-02	1.078
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.197116e-02	1.143
FOXO-mediated transcription	R-HSA-9614085	8.723027e-02	1.059
MECP2 regulates transcription factors	R-HSA-9022707	8.416291e-02	1.075
Transcriptional Regulation by VENTX	R-HSA-8853884	8.394162e-02	1.076
Signaling by NOTCH3	R-HSA-9012852	8.598247e-02	1.066
p75 NTR receptor-mediated signalling	R-HSA-193704	8.723027e-02	1.059
MAPK1/MAPK3 signaling	R-HSA-5684996	8.812879e-02	1.055
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	9.154772e-02	1.038
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	9.154772e-02	1.038
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	9.154772e-02	1.038
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	1.341329e-01	0.872
Mitochondrial transcription initiation	R-HSA-163282	1.341329e-01	0.872
Defective VWF binding to collagen type I	R-HSA-9845622	1.341329e-01	0.872
IKBKB deficiency causes SCID	R-HSA-5602636	1.341329e-01	0.872
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.341329e-01	0.872
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	1.341329e-01	0.872
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.341329e-01	0.872
PTEN Loss of Function in Cancer	R-HSA-5674404	1.341329e-01	0.872
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.341329e-01	0.872
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.341329e-01	0.872
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.747243e-01	0.758
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.747243e-01	0.758
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	1.747243e-01	0.758
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	1.747243e-01	0.758
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	1.747243e-01	0.758
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.134151e-01	0.671
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.134151e-01	0.671
Defective GSS causes GSS deficiency	R-HSA-5579006	2.134151e-01	0.671
MET activates PTPN11	R-HSA-8865999	2.134151e-01	0.671
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	9.877269e-02	1.005
Regulation of NPAS4 mRNA translation	R-HSA-9768778	9.877269e-02	1.005
Signaling by MRAS-complex mutants	R-HSA-9660537	9.877269e-02	1.005
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.877269e-02	1.005
ALK mutants bind TKIs	R-HSA-9700645	1.140258e-01	0.943
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.502943e-01	0.602
HCN channels	R-HSA-1296061	2.502943e-01	0.602
TNFR1-mediated ceramide production	R-HSA-5626978	2.502943e-01	0.602
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.502943e-01	0.602
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.502943e-01	0.602
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.502943e-01	0.602
Signaling by MAP2K mutants	R-HSA-9652169	2.502943e-01	0.602
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.461004e-01	0.835
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	1.461004e-01	0.835
Signaling by APC mutants	R-HSA-4839744	1.461004e-01	0.835
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.461004e-01	0.835
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.461004e-01	0.835
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.461004e-01	0.835
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.854465e-01	0.544
IRS activation	R-HSA-74713	2.854465e-01	0.544
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	2.854465e-01	0.544
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	2.854465e-01	0.544
Signaling by GSK3beta mutants	R-HSA-5339716	1.627586e-01	0.788
RUNX3 regulates p14-ARF	R-HSA-8951936	1.797327e-01	0.745
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.797327e-01	0.745
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.797327e-01	0.745
IRAK1 recruits IKK complex	R-HSA-937039	1.797327e-01	0.745
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.797327e-01	0.745
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.797327e-01	0.745
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.797327e-01	0.745
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.797327e-01	0.745
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.797327e-01	0.745
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.189525e-01	0.496
Signalling to p38 via RIT and RIN	R-HSA-187706	3.189525e-01	0.496
Phosphorylation of Emi1	R-HSA-176417	3.189525e-01	0.496
PKB-mediated events	R-HSA-109703	3.189525e-01	0.496
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.189525e-01	0.496
PDE3B signalling	R-HSA-165160	3.189525e-01	0.496
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.189525e-01	0.496
Signaling by RNF43 mutants	R-HSA-5340588	3.189525e-01	0.496
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.203969e-01	0.919
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.203969e-01	0.919
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.309692e-01	0.883
Signaling by Erythropoietin	R-HSA-9006335	9.002694e-02	1.046
DNA methylation	R-HSA-5334118	9.002694e-02	1.046
Late endosomal microautophagy	R-HSA-9615710	9.002694e-02	1.046
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.722400e-02	1.012
SHC-mediated cascade:FGFR4	R-HSA-5654719	1.418531e-01	0.848
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.508893e-01	0.455
STAT5 Activation	R-HSA-9645135	3.508893e-01	0.455
Erythropoietin activates STAT5	R-HSA-9027283	3.508893e-01	0.455
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.508893e-01	0.455
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	3.508893e-01	0.455
FGFR2 alternative splicing	R-HSA-6803529	1.530257e-01	0.815
Spry regulation of FGF signaling	R-HSA-1295596	2.319165e-01	0.635
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.319165e-01	0.635
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.319165e-01	0.635
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.319165e-01	0.635
Beta-catenin phosphorylation cascade	R-HSA-196299	2.319165e-01	0.635
SHC1 events in EGFR signaling	R-HSA-180336	2.319165e-01	0.635
Regulation of PTEN mRNA translation	R-HSA-8943723	1.644645e-01	0.784
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.644645e-01	0.784
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.644645e-01	0.784
Deadenylation of mRNA	R-HSA-429947	1.761468e-01	0.754
SHC-mediated cascade:FGFR1	R-HSA-5654688	1.761468e-01	0.754
Negative regulation of FLT3	R-HSA-9706369	2.495463e-01	0.603
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.672129e-01	0.573
PRC2 methylates histones and DNA	R-HSA-212300	1.544007e-01	0.811
Interaction between L1 and Ankyrins	R-HSA-445095	2.124346e-01	0.673
SHC-mediated cascade:FGFR2	R-HSA-5654699	2.124346e-01	0.673
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.124346e-01	0.673
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.124346e-01	0.673
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.248726e-01	0.648
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.248726e-01	0.648
HIV elongation arrest and recovery	R-HSA-167287	2.248726e-01	0.648
Formation of the Early Elongation Complex	R-HSA-113418	2.248726e-01	0.648
Pausing and recovery of HIV elongation	R-HSA-167290	2.248726e-01	0.648
RNA Polymerase III Transcription Termination	R-HSA-73980	3.024915e-01	0.519
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.374471e-01	0.624
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.374471e-01	0.624
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.915831e-01	0.718
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.300551e-01	0.886
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.300551e-01	0.886
RNA Polymerase I Promoter Escape	R-HSA-73772	1.646890e-01	0.783
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.012889e-01	0.696
PI-3K cascade:FGFR3	R-HSA-5654710	3.200307e-01	0.495
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.200307e-01	0.495
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.200307e-01	0.495
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.724881e-01	0.763
MAP2K and MAPK activation	R-HSA-5674135	2.111374e-01	0.675
Downstream signal transduction	R-HSA-186763	2.629265e-01	0.580
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.374603e-01	0.472
PI-3K cascade:FGFR4	R-HSA-5654720	3.374603e-01	0.472
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.374603e-01	0.472
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.374603e-01	0.472
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.374603e-01	0.472
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.374603e-01	0.472
HDACs deacetylate histones	R-HSA-3214815	1.884982e-01	0.725
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.758424e-01	0.755
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.972356e-01	0.705
mRNA Splicing - Minor Pathway	R-HSA-72165	2.621505e-01	0.581
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.146903e-01	0.502
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.726338e-01	0.564
Centrosome maturation	R-HSA-380287	2.120095e-01	0.674
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.889387e-01	0.724
Separation of Sister Chromatids	R-HSA-2467813	1.046806e-01	0.980
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.407042e-01	0.468
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.751451e-01	0.560
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.259014e-01	0.487
Formation of RNA Pol II elongation complex	R-HSA-112382	3.259014e-01	0.487
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.366585e-01	0.473
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.366585e-01	0.473
PTEN Regulation	R-HSA-6807070	2.214401e-01	0.655
EGFR downregulation	R-HSA-182971	1.046810e-01	0.980
HIV Transcription Elongation	R-HSA-167169	1.915831e-01	0.718
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.887212e-01	0.540
G0 and Early G1	R-HSA-1538133	2.757935e-01	0.559
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.305555e-01	0.481
Regulation of mitotic cell cycle	R-HSA-453276	3.305555e-01	0.481
Crosslinking of collagen fibrils	R-HSA-2243919	3.200307e-01	0.495
mRNA Capping	R-HSA-72086	2.374471e-01	0.624
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.761468e-01	0.754
Activation of the pre-replicative complex	R-HSA-68962	2.501381e-01	0.602
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.020410e-01	0.695
Regulation of endogenous retroelements	R-HSA-9842860	9.859352e-02	1.006
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.915831e-01	0.718
Chromosome Maintenance	R-HSA-73886	3.240675e-01	0.489
Signaling downstream of RAS mutants	R-HSA-9649948	1.211407e-01	0.917
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.211407e-01	0.917
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.211407e-01	0.917
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.124346e-01	0.673
Signaling by RAF1 mutants	R-HSA-9656223	2.111374e-01	0.675
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.536904e-01	0.451
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.212216e-01	0.493
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.672129e-01	0.573
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.102399e-02	1.041
MET activates RAS signaling	R-HSA-8851805	1.797327e-01	0.745
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.820308e-01	0.740
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.887212e-01	0.540
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.421860e-01	0.847
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.146903e-01	0.502
Resolution of D-Loop Structures	R-HSA-5693537	3.016923e-01	0.520
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.053531e-01	0.687
RNA Polymerase III Transcription	R-HSA-74158	3.407042e-01	0.468
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.189525e-01	0.496
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.319165e-01	0.635
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.369405e-01	0.863
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.915831e-01	0.718
E2F mediated regulation of DNA replication	R-HSA-113510	3.200307e-01	0.495
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.887212e-01	0.540
Laminin interactions	R-HSA-3000157	1.880505e-01	0.726
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.012889e-01	0.696
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	1.797327e-01	0.745
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.369405e-01	0.863
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.828656e-01	0.738
NoRC negatively regulates rRNA expression	R-HSA-427413	1.828656e-01	0.738
PIP3 activates AKT signaling	R-HSA-1257604	1.294328e-01	0.888
GPER1 signaling	R-HSA-9634597	1.350019e-01	0.870
Frs2-mediated activation	R-HSA-170968	1.969566e-01	0.706
Signaling by WNT in cancer	R-HSA-4791275	1.123898e-01	0.949
DNA Replication Pre-Initiation	R-HSA-69002	1.328265e-01	0.877
Transcription from mitochondrial promoters	R-HSA-75944	1.747243e-01	0.758
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.854465e-01	0.544
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	9.722400e-02	1.012
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.143697e-01	0.669
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.508893e-01	0.455
Signaling by RAS mutants	R-HSA-6802949	1.211407e-01	0.917
IRS-mediated signalling	R-HSA-112399	9.610722e-02	1.017
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.634291e-01	0.787
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.887212e-01	0.540
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.504862e-01	0.601
Meiotic synapsis	R-HSA-1221632	3.366585e-01	0.473
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.366585e-01	0.473
Clathrin-mediated endocytosis	R-HSA-8856828	9.226700e-02	1.035
DAP12 signaling	R-HSA-2424491	2.501381e-01	0.602
Signaling by Insulin receptor	R-HSA-74752	1.221037e-01	0.913
RNA Polymerase I Transcription	R-HSA-73864	1.239104e-01	0.907
Adipogenesis	R-HSA-9843745	1.743603e-01	0.759
Interleukin-2 signaling	R-HSA-9020558	1.461004e-01	0.835
Chaperone Mediated Autophagy	R-HSA-9613829	3.024915e-01	0.519
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.934324e-01	0.532
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.306347e-01	0.637
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.306347e-01	0.637
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.306347e-01	0.637
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.306347e-01	0.637
Signaling by NOTCH1	R-HSA-1980143	1.135205e-01	0.945
Assembly of the pre-replicative complex	R-HSA-68867	1.269510e-01	0.896
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.018447e-01	0.992
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.002773e-01	0.999
Signalling to RAS	R-HSA-167044	1.309692e-01	0.883
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.143697e-01	0.669
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.135205e-01	0.945
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	3.200307e-01	0.495
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.536904e-01	0.451
Switching of origins to a post-replicative state	R-HSA-69052	3.492931e-01	0.457
TNF signaling	R-HSA-75893	9.096814e-02	1.041
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.575838e-01	0.589
Vasopressin-like receptors	R-HSA-388479	2.502943e-01	0.602
Repression of WNT target genes	R-HSA-4641265	1.797327e-01	0.745
Mitotic Prometaphase	R-HSA-68877	1.473216e-01	0.832
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.941105e-01	0.712
Intracellular signaling by second messengers	R-HSA-9006925	2.192487e-01	0.659
Interleukin-2 family signaling	R-HSA-451927	1.915831e-01	0.718
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.941105e-01	0.712
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.110727e-01	0.676
Nuclear RNA decay	R-HSA-9930044	2.887212e-01	0.540
G1 Phase	R-HSA-69236	1.079879e-01	0.967
Cyclin D associated events in G1	R-HSA-69231	1.079879e-01	0.967
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.374471e-01	0.624
Neurexins and neuroligins	R-HSA-6794361	3.259014e-01	0.487
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.110727e-01	0.676
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.127097e-01	0.948
Regulation of TNFR1 signaling	R-HSA-5357905	1.211407e-01	0.917
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	2.854465e-01	0.544
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.627586e-01	0.788
Signaling by AMER1 mutants	R-HSA-4839748	1.627586e-01	0.788
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.002773e-01	0.999
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.797327e-01	0.745
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.189525e-01	0.496
CDC6 association with the ORC:origin complex	R-HSA-68689	3.189525e-01	0.496
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.969566e-01	0.706
ATP-dependent chromatin remodelers	R-HSA-9932444	1.880505e-01	0.726
SWI/SNF chromatin remodelers	R-HSA-9932451	1.880505e-01	0.726
Metalloprotease DUBs	R-HSA-5689901	2.001536e-01	0.699
Regulation of FZD by ubiquitination	R-HSA-4641263	2.848740e-01	0.545
Synaptic adhesion-like molecules	R-HSA-8849932	3.024915e-01	0.519
PKA activation in glucagon signalling	R-HSA-164378	3.024915e-01	0.519
PI3K Cascade	R-HSA-109704	1.495322e-01	0.825
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.200307e-01	0.495
Budding and maturation of HIV virion	R-HSA-162588	2.629265e-01	0.580
Negative regulation of MET activity	R-HSA-6807004	3.374603e-01	0.472
Meiosis	R-HSA-1500620	1.638420e-01	0.786
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.146903e-01	0.502
Mitotic Anaphase	R-HSA-68882	1.095772e-01	0.960
Cilium Assembly	R-HSA-5617833	3.062272e-01	0.514
Protein-protein interactions at synapses	R-HSA-6794362	1.638420e-01	0.786
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.124561e-01	0.949
Prolonged ERK activation events	R-HSA-169893	2.495463e-01	0.603
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.350019e-01	0.870
TCF dependent signaling in response to WNT	R-HSA-201681	1.130601e-01	0.947
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.135872e-01	0.504
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.399146e-01	0.469
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.203420e-01	0.920
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.501381e-01	0.602
Differentiation of T cells	R-HSA-9945266	2.495463e-01	0.603
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.495463e-01	0.603
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.282420e-01	0.892
Neurofascin interactions	R-HSA-447043	3.508893e-01	0.455
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.504862e-01	0.601
DCC mediated attractive signaling	R-HSA-418885	2.319165e-01	0.635
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.306347e-01	0.637
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.724586e-01	0.763
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.555421e-01	0.593
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.189525e-01	0.496
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.143697e-01	0.669
Meiotic recombination	R-HSA-912446	1.570351e-01	0.804
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.557819e-02	1.020
Axon guidance	R-HSA-422475	1.106086e-01	0.956
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.799683e-01	0.745
Signaling by WNT	R-HSA-195721	1.378535e-01	0.861
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.140258e-01	0.943
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.143697e-01	0.669
Signaling by VEGF	R-HSA-194138	2.345636e-01	0.630
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.887212e-01	0.540
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.144777e-01	0.669
Nervous system development	R-HSA-9675108	1.919178e-01	0.717
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.328265e-01	0.877
Sensory perception of sour taste	R-HSA-9729555	2.502943e-01	0.602
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.298301e-01	0.887
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.854465e-01	0.544
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.189525e-01	0.496
Retrograde neurotrophin signalling	R-HSA-177504	2.143697e-01	0.669
Activation of ATR in response to replication stress	R-HSA-176187	1.203420e-01	0.920
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.495463e-01	0.603
Signaling by FGFR3 in disease	R-HSA-5655332	2.124346e-01	0.673
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.211181e-01	0.655
Defective pyroptosis	R-HSA-9710421	2.312203e-01	0.636
Signaling by NOTCH	R-HSA-157118	1.276817e-01	0.894
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.169004e-01	0.499
Transcriptional regulation by RUNX1	R-HSA-8878171	1.403860e-01	0.853
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.134499e-01	0.671
Oxidative Stress Induced Senescence	R-HSA-2559580	1.806069e-01	0.743
Signaling by Nuclear Receptors	R-HSA-9006931	1.647392e-01	0.783
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.421860e-01	0.847
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.421860e-01	0.847
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.520014e-01	0.818
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.672287e-01	0.777
Signaling by Hippo	R-HSA-2028269	2.848740e-01	0.545
Cardiogenesis	R-HSA-9733709	2.887212e-01	0.540
Collagen degradation	R-HSA-1442490	2.393728e-01	0.621
Response of endothelial cells to shear stress	R-HSA-9860931	3.169004e-01	0.499
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.298301e-01	0.887
Tie2 Signaling	R-HSA-210993	1.002773e-01	0.999
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.508893e-01	0.455
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.508893e-01	0.455
Ovarian tumor domain proteases	R-HSA-5689896	1.634291e-01	0.787
Signaling by FGFR2 in disease	R-HSA-5655253	1.495322e-01	0.825
Interleukin-17 signaling	R-HSA-448424	1.758424e-01	0.755
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.276993e-01	0.485
MAP kinase activation	R-HSA-450294	2.393728e-01	0.621
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.321196e-01	0.479
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.920189e-02	1.050
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.079879e-01	0.967
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.024915e-01	0.519
Reproduction	R-HSA-1474165	2.714270e-01	0.566
HCMV Late Events	R-HSA-9610379	2.248141e-01	0.648
L1CAM interactions	R-HSA-373760	1.777634e-01	0.750
Cell junction organization	R-HSA-446728	2.696007e-01	0.569
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.134151e-01	0.671
Dopamine receptors	R-HSA-390651	2.502943e-01	0.602
NrCAM interactions	R-HSA-447038	2.854465e-01	0.544
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.854465e-01	0.544
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.854465e-01	0.544
Anchoring fibril formation	R-HSA-2214320	1.627586e-01	0.788
Relaxin receptors	R-HSA-444821	3.189525e-01	0.496
Signaling by PDGFR in disease	R-HSA-9671555	1.418531e-01	0.848
CREB phosphorylation	R-HSA-199920	3.508893e-01	0.455
NADPH regeneration	R-HSA-389542	3.508893e-01	0.455
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.495463e-01	0.603
Fibronectin matrix formation	R-HSA-1566977	2.672129e-01	0.573
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.887212e-01	0.540
Deubiquitination	R-HSA-5688426	1.190115e-01	0.924
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.203420e-01	0.920
Adherens junctions interactions	R-HSA-418990	1.770553e-01	0.752
Cell-cell junction organization	R-HSA-421270	2.356807e-01	0.628
Cell-Cell communication	R-HSA-1500931	3.518929e-01	0.454
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.386375e-01	0.622
Protein methylation	R-HSA-8876725	2.319165e-01	0.635
Ca2+ pathway	R-HSA-4086398	3.492931e-01	0.457
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.194187e-01	0.496
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.194187e-01	0.496
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.530257e-01	0.815
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.374471e-01	0.624
G1/S DNA Damage Checkpoints	R-HSA-69615	2.571080e-01	0.590
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.418531e-01	0.848
Specification of primordial germ cells	R-HSA-9827857	2.848740e-01	0.545
Oncogene Induced Senescence	R-HSA-2559585	3.276993e-01	0.485
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.311536e-01	0.480
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.248726e-01	0.648
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.854465e-01	0.544
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.854465e-01	0.544
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.189525e-01	0.496
Release of Hh-Np from the secreting cell	R-HSA-5362798	3.189525e-01	0.496
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.189525e-01	0.496
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.189525e-01	0.496
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.016923e-01	0.520
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.294932e-01	0.639
MAPK6/MAPK4 signaling	R-HSA-5687128	2.907226e-01	0.537
Transcriptional regulation by RUNX2	R-HSA-8878166	1.120334e-01	0.951
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.374471e-01	0.624
Regulation of NPAS4 gene expression	R-HSA-9768759	2.848740e-01	0.545
Signaling by NOTCH2	R-HSA-1980145	3.146903e-01	0.502
PKR-mediated signaling	R-HSA-9833482	1.347664e-01	0.870
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.189525e-01	0.496
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	1.369405e-01	0.863
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.644645e-01	0.784
Uptake and function of anthrax toxins	R-HSA-5210891	2.848740e-01	0.545
Host Interactions of HIV factors	R-HSA-162909	3.452853e-01	0.462
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.319165e-01	0.635
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.146903e-01	0.502
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.212216e-01	0.493
Diseases of programmed cell death	R-HSA-9645723	3.238020e-01	0.490
Nectin/Necl trans heterodimerization	R-HSA-420597	2.854465e-01	0.544
Regulation of KIT signaling	R-HSA-1433559	2.143697e-01	0.669
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.672129e-01	0.573
MITF-M-regulated melanocyte development	R-HSA-9730414	2.348315e-01	0.629
Collagen chain trimerization	R-HSA-8948216	3.536904e-01	0.451
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.229320e-01	0.491
Triglyceride catabolism	R-HSA-163560	3.407042e-01	0.468
Maturation of hRSV A proteins	R-HSA-9828806	2.124346e-01	0.673
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	1.820308e-01	0.740
ERK/MAPK targets	R-HSA-198753	3.547520e-01	0.450
Zygotic genome activation (ZGA)	R-HSA-9819196	3.547520e-01	0.450
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.547520e-01	0.450
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.547520e-01	0.450
Influenza Infection	R-HSA-168255	3.548694e-01	0.450
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.582044e-01	0.446
Signaling by FGFR in disease	R-HSA-1226099	3.586852e-01	0.445
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.666444e-01	0.436
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.666444e-01	0.436
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.689763e-01	0.433
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.689763e-01	0.433
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.705605e-01	0.431
MyD88-independent TLR4 cascade	R-HSA-166166	3.705605e-01	0.431
FRS-mediated FGFR3 signaling	R-HSA-5654706	3.718804e-01	0.430
Assembly Of The HIV Virion	R-HSA-175474	3.718804e-01	0.430
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.795531e-01	0.421
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.800483e-01	0.420
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.813304e-01	0.419
MET activates PI3K/AKT signaling	R-HSA-8851907	3.813304e-01	0.419
Regulation of PTEN localization	R-HSA-8948747	3.813304e-01	0.419
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	3.813304e-01	0.419
RUNX3 regulates WNT signaling	R-HSA-8951430	3.813304e-01	0.419
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.813304e-01	0.419
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.813304e-01	0.419
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.813304e-01	0.419
Class I MHC mediated antigen processing & presentation	R-HSA-983169	3.865003e-01	0.413
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.868871e-01	0.412
PI-3K cascade:FGFR1	R-HSA-5654689	3.888230e-01	0.410
FRS-mediated FGFR4 signaling	R-HSA-5654712	3.888230e-01	0.410
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.888230e-01	0.410
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.888230e-01	0.410
mTORC1-mediated signalling	R-HSA-166208	3.888230e-01	0.410
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.911443e-01	0.408
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.924042e-01	0.406
Diseases of Immune System	R-HSA-5260271	3.924042e-01	0.406
SLC transporter disorders	R-HSA-5619102	3.967775e-01	0.401
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	4.011922e-01	0.397
Triglyceride metabolism	R-HSA-8979227	4.011922e-01	0.397
Cellular responses to mechanical stimuli	R-HSA-9855142	4.015068e-01	0.396
Syndecan interactions	R-HSA-3000170	4.055594e-01	0.392
Growth hormone receptor signaling	R-HSA-982772	4.055594e-01	0.392
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.056557e-01	0.392
ROBO receptors bind AKAP5	R-HSA-9010642	4.103456e-01	0.387
Type I hemidesmosome assembly	R-HSA-446107	4.103456e-01	0.387
MET receptor recycling	R-HSA-8875656	4.103456e-01	0.387
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.103456e-01	0.387
Formation of annular gap junctions	R-HSA-196025	4.103456e-01	0.387
TGFBR3 PTM regulation	R-HSA-9839383	4.103456e-01	0.387
Adrenoceptors	R-HSA-390696	4.103456e-01	0.387
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.103456e-01	0.387
Sodium/Proton exchangers	R-HSA-425986	4.103456e-01	0.387
SARS-CoV-2-host interactions	R-HSA-9705683	4.130684e-01	0.384
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.150148e-01	0.382
Transcriptional regulation by RUNX3	R-HSA-8878159	4.164633e-01	0.380
Negative regulation of MAPK pathway	R-HSA-5675221	4.178879e-01	0.379
SLC-mediated transport of neurotransmitters	R-HSA-442660	4.178879e-01	0.379
Signaling by FGFR1 in disease	R-HSA-5655302	4.178879e-01	0.379
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.178879e-01	0.379
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.220718e-01	0.375
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.220718e-01	0.375
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.220718e-01	0.375
Neurodegenerative Diseases	R-HSA-8863678	4.220718e-01	0.375
TNFs bind their physiological receptors	R-HSA-5669034	4.220718e-01	0.375
tRNA processing	R-HSA-72306	4.222190e-01	0.374
Toll-like Receptor Cascades	R-HSA-168898	4.271240e-01	0.369
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.304992e-01	0.366
Cleavage of the damaged pyrimidine	R-HSA-110329	4.304992e-01	0.366
Depyrimidination	R-HSA-73928	4.304992e-01	0.366
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.331039e-01	0.363
Signaling by PDGF	R-HSA-186797	4.331039e-01	0.363
DNA Replication	R-HSA-69306	4.366978e-01	0.360
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.380017e-01	0.359
Lipophagy	R-HSA-9613354	4.380017e-01	0.359
GP1b-IX-V activation signalling	R-HSA-430116	4.380017e-01	0.359
Gap junction degradation	R-HSA-190873	4.380017e-01	0.359
Calcineurin activates NFAT	R-HSA-2025928	4.380017e-01	0.359
Unwinding of DNA	R-HSA-176974	4.380017e-01	0.359
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.380017e-01	0.359
Interleukin-1 processing	R-HSA-448706	4.380017e-01	0.359
Regulated proteolysis of p75NTR	R-HSA-193692	4.380017e-01	0.359
Regulation of CDH11 gene transcription	R-HSA-9762293	4.380017e-01	0.359
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.380017e-01	0.359
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.380017e-01	0.359
PI-3K cascade:FGFR2	R-HSA-5654695	4.383445e-01	0.358
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.383445e-01	0.358
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.383445e-01	0.358
Acyl chain remodelling of PS	R-HSA-1482801	4.383445e-01	0.358
Sema4D in semaphorin signaling	R-HSA-400685	4.383445e-01	0.358
MicroRNA (miRNA) biogenesis	R-HSA-203927	4.383445e-01	0.358
Signaling by SCF-KIT	R-HSA-1433557	4.430105e-01	0.354
Signaling by PTK6	R-HSA-8848021	4.436419e-01	0.353
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.436419e-01	0.353
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.521711e-01	0.345
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.543635e-01	0.343
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.543635e-01	0.343
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.543635e-01	0.343
Attachment of bacteria to epithelial cells	R-HSA-9638630	4.543635e-01	0.343
MET activates PTK2 signaling	R-HSA-8874081	4.543635e-01	0.343
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.543635e-01	0.343
Myogenesis	R-HSA-525793	4.543635e-01	0.343
TRP channels	R-HSA-3295583	4.543635e-01	0.343
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.543635e-01	0.343
RMTs methylate histone arginines	R-HSA-3214858	4.554128e-01	0.342
DAP12 interactions	R-HSA-2172127	4.554128e-01	0.342
Netrin-1 signaling	R-HSA-373752	4.554128e-01	0.342
Cellular responses to stimuli	R-HSA-8953897	4.629708e-01	0.334
MET activates RAP1 and RAC1	R-HSA-8875555	4.643623e-01	0.333
MAPK3 (ERK1) activation	R-HSA-110056	4.643623e-01	0.333
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.643623e-01	0.333
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.643623e-01	0.333
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.643623e-01	0.333
Regulation of the apoptosome activity	R-HSA-9627069	4.643623e-01	0.333
Formation of apoptosome	R-HSA-111458	4.643623e-01	0.333
PI3K/AKT activation	R-HSA-198203	4.643623e-01	0.333
EGFR Transactivation by Gastrin	R-HSA-2179392	4.643623e-01	0.333
Apoptosis induced DNA fragmentation	R-HSA-140342	4.643623e-01	0.333
Signaling by Leptin	R-HSA-2586552	4.643623e-01	0.333
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.676977e-01	0.330
Nucleosome assembly	R-HSA-774815	4.676977e-01	0.330
Fanconi Anemia Pathway	R-HSA-6783310	4.676977e-01	0.330
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.676977e-01	0.330
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.676977e-01	0.330
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.701170e-01	0.328
Packaging Of Telomere Ends	R-HSA-171306	4.701170e-01	0.328
RNA Polymerase I Transcription Termination	R-HSA-73863	4.701170e-01	0.328
Signaling by BMP	R-HSA-201451	4.701170e-01	0.328
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.701170e-01	0.328
Interferon Signaling	R-HSA-913531	4.756445e-01	0.323
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.798576e-01	0.319
Diseases of DNA repair	R-HSA-9675135	4.798576e-01	0.319
Apoptotic execution phase	R-HSA-75153	4.798576e-01	0.319
Co-inhibition by PD-1	R-HSA-389948	4.812721e-01	0.318
Telomere Extension By Telomerase	R-HSA-171319	4.855946e-01	0.314
FRS-mediated FGFR2 signaling	R-HSA-5654700	4.855946e-01	0.314
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.894879e-01	0.310
Synthesis of PI	R-HSA-1483226	4.894879e-01	0.310
Bicarbonate transporters	R-HSA-425381	4.894879e-01	0.310
PECAM1 interactions	R-HSA-210990	4.894879e-01	0.310
Nucleotide Excision Repair	R-HSA-5696398	4.913017e-01	0.309
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.918851e-01	0.308
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.918851e-01	0.308
Recycling pathway of L1	R-HSA-437239	4.918851e-01	0.308
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.953196e-01	0.305
Cytokine Signaling in Immune system	R-HSA-1280215	4.954085e-01	0.305
DARPP-32 events	R-HSA-180024	5.007875e-01	0.300
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.007875e-01	0.300
Glucagon-type ligand receptors	R-HSA-420092	5.007875e-01	0.300
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.134364e-01	0.290
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.134364e-01	0.290
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.134364e-01	0.290
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.134364e-01	0.290
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.134364e-01	0.290
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.134364e-01	0.290
Activation of RAC1	R-HSA-428540	5.134364e-01	0.290
ERKs are inactivated	R-HSA-202670	5.134364e-01	0.290
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.134364e-01	0.290
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.134364e-01	0.290
DS-GAG biosynthesis	R-HSA-2022923	5.134364e-01	0.290
Cellular responses to stress	R-HSA-2262752	5.134491e-01	0.290
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.156884e-01	0.288
Cargo trafficking to the periciliary membrane	R-HSA-5620920	5.253326e-01	0.280
Evasion by RSV of host interferon responses	R-HSA-9833109	5.302913e-01	0.275
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.362629e-01	0.271
GRB2 events in EGFR signaling	R-HSA-179812	5.362629e-01	0.271
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.362629e-01	0.271
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.362629e-01	0.271
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.362629e-01	0.271
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.362629e-01	0.271
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.362629e-01	0.271
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.362629e-01	0.271
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.362629e-01	0.271
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	5.445913e-01	0.264
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	5.445913e-01	0.264
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.445913e-01	0.264
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.580198e-01	0.253
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.580198e-01	0.253
Platelet Adhesion to exposed collagen	R-HSA-75892	5.580198e-01	0.253
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.580198e-01	0.253
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.580198e-01	0.253
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.580198e-01	0.253
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.580198e-01	0.253
Processing of SMDT1	R-HSA-8949664	5.580198e-01	0.253
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	5.580198e-01	0.253
Interleukin-6 signaling	R-HSA-1059683	5.580198e-01	0.253
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.580198e-01	0.253
Integrin signaling	R-HSA-354192	5.585848e-01	0.253
Regulation of necroptotic cell death	R-HSA-5675482	5.585848e-01	0.253
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.587306e-01	0.253
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.609396e-01	0.251
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.639533e-01	0.249
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.718854e-01	0.243
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.718854e-01	0.243
Glucagon signaling in metabolic regulation	R-HSA-163359	5.722689e-01	0.242
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.722689e-01	0.242
Ub-specific processing proteases	R-HSA-5689880	5.734696e-01	0.241
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.779491e-01	0.238
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.787572e-01	0.238
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.787572e-01	0.238
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.787572e-01	0.238
Respiratory syncytial virus genome transcription	R-HSA-9828642	5.787572e-01	0.238
HDL assembly	R-HSA-8963896	5.787572e-01	0.238
P2Y receptors	R-HSA-417957	5.787572e-01	0.238
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.787572e-01	0.238
HCMV Early Events	R-HSA-9609690	5.825747e-01	0.235
COPI-mediated anterograde transport	R-HSA-6807878	5.837468e-01	0.234
NOD1/2 Signaling Pathway	R-HSA-168638	5.856420e-01	0.232
Interleukin-10 signaling	R-HSA-6783783	5.917560e-01	0.228
Telomere Maintenance	R-HSA-157579	5.919138e-01	0.228
Ion homeostasis	R-HSA-5578775	5.932613e-01	0.227
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.932613e-01	0.227
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.985228e-01	0.223
RNA Polymerase III Chain Elongation	R-HSA-73780	5.985228e-01	0.223
Telomere C-strand synthesis initiation	R-HSA-174430	5.985228e-01	0.223
Protein lipoylation	R-HSA-9857492	5.985228e-01	0.223
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.985228e-01	0.223
Translesion synthesis by REV1	R-HSA-110312	5.985228e-01	0.223
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.985228e-01	0.223
Signaling by Activin	R-HSA-1502540	5.985228e-01	0.223
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.985228e-01	0.223
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.985228e-01	0.223
p38MAPK events	R-HSA-171007	5.985228e-01	0.223
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.987030e-01	0.223
Signaling by Interleukins	R-HSA-449147	5.989160e-01	0.223
Sensory processing of sound	R-HSA-9659379	6.007880e-01	0.221
HSF1 activation	R-HSA-3371511	6.114519e-01	0.214
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.114519e-01	0.214
GPVI-mediated activation cascade	R-HSA-114604	6.114519e-01	0.214
FGFR2 mutant receptor activation	R-HSA-1839126	6.114519e-01	0.214
Hedgehog 'off' state	R-HSA-5610787	6.158729e-01	0.211
Translesion synthesis by POLI	R-HSA-5656121	6.173621e-01	0.209
Regulation of NF-kappa B signaling	R-HSA-9758274	6.173621e-01	0.209
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.173621e-01	0.209
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.173621e-01	0.209
Activation of SMO	R-HSA-5635838	6.173621e-01	0.209
Interleukin-1 signaling	R-HSA-9020702	6.236731e-01	0.205
Degradation of AXIN	R-HSA-4641257	6.238891e-01	0.205
TRAF6 mediated IRF7 activation	R-HSA-933541	6.238891e-01	0.205
Cleavage of the damaged purine	R-HSA-110331	6.238891e-01	0.205
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.238891e-01	0.205
Deadenylation-dependent mRNA decay	R-HSA-429914	6.239998e-01	0.205
Kinesins	R-HSA-983189	6.338854e-01	0.198
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.353185e-01	0.197
Translesion synthesis by POLK	R-HSA-5655862	6.353185e-01	0.197
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.353185e-01	0.197
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.353185e-01	0.197
Glycine degradation	R-HSA-6783984	6.353185e-01	0.197
Coenzyme A biosynthesis	R-HSA-196783	6.353185e-01	0.197
Disorders of Developmental Biology	R-HSA-9675151	6.353185e-01	0.197
tRNA modification in the mitochondrion	R-HSA-6787450	6.353185e-01	0.197
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.353185e-01	0.197
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.356846e-01	0.197
Depurination	R-HSA-73927	6.360159e-01	0.197
Biofilm formation	R-HSA-9931953	6.360159e-01	0.197
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.360159e-01	0.197
Aquaporin-mediated transport	R-HSA-445717	6.435889e-01	0.191
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.440932e-01	0.191
HCMV Infection	R-HSA-9609646	6.445543e-01	0.191
Adaptive Immune System	R-HSA-1280218	6.463181e-01	0.190
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.524333e-01	0.185
PI3K events in ERBB2 signaling	R-HSA-1963642	6.524333e-01	0.185
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.524333e-01	0.185
Glycogen storage diseases	R-HSA-3229121	6.524333e-01	0.185
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.524333e-01	0.185
NCAM signaling for neurite out-growth	R-HSA-375165	6.531093e-01	0.185
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.531093e-01	0.185
RSV-host interactions	R-HSA-9833110	6.539077e-01	0.184
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.593455e-01	0.181
Aggrephagy	R-HSA-9646399	6.593455e-01	0.181
Semaphorin interactions	R-HSA-373755	6.624464e-01	0.179
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.624464e-01	0.179
Developmental Biology	R-HSA-1266738	6.644907e-01	0.178
SARS-CoV-1-host interactions	R-HSA-9692914	6.684304e-01	0.175
Ephrin signaling	R-HSA-3928664	6.687458e-01	0.175
GAB1 signalosome	R-HSA-180292	6.687458e-01	0.175
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.687458e-01	0.175
Apoptotic factor-mediated response	R-HSA-111471	6.687458e-01	0.175
PKA activation	R-HSA-163615	6.687458e-01	0.175
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.687458e-01	0.175
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.687458e-01	0.175
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.687458e-01	0.175
Vitamin D (calciferol) metabolism	R-HSA-196791	6.687458e-01	0.175
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.705533e-01	0.174
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.705533e-01	0.174
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.715998e-01	0.173
Regulation of T cell activation by CD28 family	R-HSA-388841	6.735037e-01	0.172
Synthesis of DNA	R-HSA-69239	6.755401e-01	0.170
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.814606e-01	0.167
Scavenging by Class A Receptors	R-HSA-3000480	6.814606e-01	0.167
Translesion Synthesis by POLH	R-HSA-110320	6.842937e-01	0.165
Regulation of signaling by CBL	R-HSA-912631	6.842937e-01	0.165
Germ layer formation at gastrulation	R-HSA-9754189	6.842937e-01	0.165
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.842937e-01	0.165
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.842937e-01	0.165
Diseases of hemostasis	R-HSA-9671793	6.842937e-01	0.165
Rap1 signalling	R-HSA-392517	6.842937e-01	0.165
STING mediated induction of host immune responses	R-HSA-1834941	6.842937e-01	0.165
The NLRP3 inflammasome	R-HSA-844456	6.842937e-01	0.165
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.842937e-01	0.165
G alpha (s) signalling events	R-HSA-418555	6.914785e-01	0.160
MTOR signalling	R-HSA-165159	6.920707e-01	0.160
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.953645e-01	0.158
Formation of definitive endoderm	R-HSA-9823730	6.991127e-01	0.155
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.991127e-01	0.155
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.991127e-01	0.155
Signaling by NODAL	R-HSA-1181150	6.991127e-01	0.155
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	6.991127e-01	0.155
Glycogen synthesis	R-HSA-3322077	6.991127e-01	0.155
Signal transduction by L1	R-HSA-445144	6.991127e-01	0.155
Nephrin family interactions	R-HSA-373753	6.991127e-01	0.155
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	7.063827e-01	0.151
Regulated Necrosis	R-HSA-5218859	7.063827e-01	0.151
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.095520e-01	0.149
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.095520e-01	0.149
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.124154e-01	0.147
EPHB-mediated forward signaling	R-HSA-3928662	7.124154e-01	0.147
Amine ligand-binding receptors	R-HSA-375280	7.124154e-01	0.147
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.132370e-01	0.147
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.132370e-01	0.147
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.132370e-01	0.147
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.132370e-01	0.147
Degradation of the extracellular matrix	R-HSA-1474228	7.136441e-01	0.147
EPH-Ephrin signaling	R-HSA-2682334	7.210033e-01	0.142
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.221586e-01	0.141
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.221586e-01	0.141
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.221586e-01	0.141
COPII-mediated vesicle transport	R-HSA-204005	7.226850e-01	0.141
SARS-CoV Infections	R-HSA-9679506	7.227453e-01	0.141
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.266990e-01	0.139
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.266990e-01	0.139
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.266990e-01	0.139
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.266990e-01	0.139
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.266990e-01	0.139
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.266990e-01	0.139
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	7.266990e-01	0.139
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.266990e-01	0.139
Glutathione synthesis and recycling	R-HSA-174403	7.266990e-01	0.139
Mitochondrial calcium ion transport	R-HSA-8949215	7.266990e-01	0.139
ECM proteoglycans	R-HSA-3000178	7.305675e-01	0.136
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.316216e-01	0.136
Disorders of transmembrane transporters	R-HSA-5619115	7.343746e-01	0.134
Collagen formation	R-HSA-1474290	7.348089e-01	0.134
Membrane Trafficking	R-HSA-199991	7.374449e-01	0.132
Signaling by ROBO receptors	R-HSA-376176	7.379009e-01	0.132
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.382729e-01	0.132
Notch-HLH transcription pathway	R-HSA-350054	7.395299e-01	0.131
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.395299e-01	0.131
RAF-independent MAPK1/3 activation	R-HSA-112409	7.395299e-01	0.131
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.395299e-01	0.131
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.395299e-01	0.131
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.395299e-01	0.131
Signaling by KIT in disease	R-HSA-9669938	7.395299e-01	0.131
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.408094e-01	0.130
Beta-catenin independent WNT signaling	R-HSA-3858494	7.424050e-01	0.129
Carnitine shuttle	R-HSA-200425	7.517592e-01	0.124
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.517592e-01	0.124
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.517592e-01	0.124
Signaling by ERBB4	R-HSA-1236394	7.531586e-01	0.123
Signaling by Hedgehog	R-HSA-5358351	7.533117e-01	0.123
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	7.545429e-01	0.122
DNA Damage Bypass	R-HSA-73893	7.583792e-01	0.120
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.603424e-01	0.119
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.634149e-01	0.117
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.634149e-01	0.117
Plasma lipoprotein assembly	R-HSA-8963898	7.634149e-01	0.117
Interleukin-6 family signaling	R-HSA-6783589	7.634149e-01	0.117
Regulation of RAS by GAPs	R-HSA-5658442	7.667716e-01	0.115
UCH proteinases	R-HSA-5689603	7.673560e-01	0.115
G protein gated Potassium channels	R-HSA-1296059	7.745241e-01	0.111
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.745241e-01	0.111
Activation of G protein gated Potassium channels	R-HSA-1296041	7.745241e-01	0.111
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.745241e-01	0.111
Long-term potentiation	R-HSA-9620244	7.745241e-01	0.111
Tight junction interactions	R-HSA-420029	7.745241e-01	0.111
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.745241e-01	0.111
SARS-CoV-2 Infection	R-HSA-9694516	7.755476e-01	0.110
Nuclear Receptor transcription pathway	R-HSA-383280	7.808813e-01	0.107
Viral Infection Pathways	R-HSA-9824446	7.812128e-01	0.107
Orc1 removal from chromatin	R-HSA-68949	7.827978e-01	0.106
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.827978e-01	0.106
Uptake and actions of bacterial toxins	R-HSA-5339562	7.827978e-01	0.106
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.827978e-01	0.106
Extra-nuclear estrogen signaling	R-HSA-9009391	7.848884e-01	0.105
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.851123e-01	0.105
Urea cycle	R-HSA-70635	7.851123e-01	0.105
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.851123e-01	0.105
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.859487e-01	0.105
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.905849e-01	0.102
PI Metabolism	R-HSA-1483255	7.905849e-01	0.102
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.929383e-01	0.101
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.952038e-01	0.100
EPHA-mediated growth cone collapse	R-HSA-3928663	7.952038e-01	0.100
Cristae formation	R-HSA-8949613	7.952038e-01	0.100
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.952038e-01	0.100
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.952038e-01	0.100
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.952038e-01	0.100
Triglyceride biosynthesis	R-HSA-75109	7.952038e-01	0.100
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.952038e-01	0.100
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.952038e-01	0.100
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	7.952038e-01	0.100
Amyloid fiber formation	R-HSA-977225	7.999470e-01	0.097
ER to Golgi Anterograde Transport	R-HSA-199977	8.027971e-01	0.095
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.048221e-01	0.094
Insulin receptor recycling	R-HSA-77387	8.048221e-01	0.094
Pyroptosis	R-HSA-5620971	8.048221e-01	0.094
Inflammasomes	R-HSA-622312	8.048221e-01	0.094
G alpha (z) signalling events	R-HSA-418597	8.050227e-01	0.094
Cytoprotection by HMOX1	R-HSA-9707564	8.118704e-01	0.091
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.119691e-01	0.090
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.119691e-01	0.090
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.119691e-01	0.090
Termination of translesion DNA synthesis	R-HSA-5656169	8.139891e-01	0.089
Activation of Matrix Metalloproteinases	R-HSA-1592389	8.139891e-01	0.089
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.139891e-01	0.089
Potential therapeutics for SARS	R-HSA-9679191	8.160437e-01	0.088
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.227262e-01	0.085
Downregulation of ERBB2 signaling	R-HSA-8863795	8.227262e-01	0.085
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.227262e-01	0.085
Neurotransmitter clearance	R-HSA-112311	8.227262e-01	0.085
Activation of BH3-only proteins	R-HSA-114452	8.227262e-01	0.085
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.244791e-01	0.084
Dual incision in TC-NER	R-HSA-6782135	8.252022e-01	0.083
Antigen processing-Cross presentation	R-HSA-1236975	8.271375e-01	0.082
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.310534e-01	0.080
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.310534e-01	0.080
Trafficking of AMPA receptors	R-HSA-399719	8.310534e-01	0.080
Cargo concentration in the ER	R-HSA-5694530	8.310534e-01	0.080
Extension of Telomeres	R-HSA-180786	8.314998e-01	0.080
Regulation of beta-cell development	R-HSA-186712	8.314998e-01	0.080
PPARA activates gene expression	R-HSA-1989781	8.365526e-01	0.078
TCR signaling	R-HSA-202403	8.365561e-01	0.078
Signaling by Retinoic Acid	R-HSA-5362517	8.375921e-01	0.077
Inwardly rectifying K+ channels	R-HSA-1296065	8.389898e-01	0.076
DNA strand elongation	R-HSA-69190	8.389898e-01	0.076
Autophagy	R-HSA-9612973	8.404256e-01	0.076
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.434843e-01	0.074
Formation of paraxial mesoderm	R-HSA-9793380	8.434843e-01	0.074
Selective autophagy	R-HSA-9663891	8.440835e-01	0.074
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.442241e-01	0.074
Programmed Cell Death	R-HSA-5357801	8.453220e-01	0.073
FCERI mediated MAPK activation	R-HSA-2871796	8.455418e-01	0.073
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.465540e-01	0.072
Recycling of bile acids and salts	R-HSA-159418	8.465540e-01	0.072
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.465540e-01	0.072
Mitochondrial protein import	R-HSA-1268020	8.491820e-01	0.071
Neurotransmitter release cycle	R-HSA-112310	8.537055e-01	0.069
Downstream TCR signaling	R-HSA-202424	8.537055e-01	0.069
Base Excision Repair	R-HSA-73884	8.537055e-01	0.069
Striated Muscle Contraction	R-HSA-390522	8.537632e-01	0.069
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.537632e-01	0.069
Acyl chain remodelling of PC	R-HSA-1482788	8.537632e-01	0.069
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.537632e-01	0.069
Effects of PIP2 hydrolysis	R-HSA-114508	8.537632e-01	0.069
Complex I biogenesis	R-HSA-6799198	8.546902e-01	0.068
Ion transport by P-type ATPases	R-HSA-936837	8.600143e-01	0.065
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.606341e-01	0.065
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.606341e-01	0.065
Calnexin/calreticulin cycle	R-HSA-901042	8.606341e-01	0.065
Apoptosis	R-HSA-109581	8.621283e-01	0.064
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.628052e-01	0.064
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.651594e-01	0.063
FCERI mediated Ca+2 mobilization	R-HSA-2871809	8.661979e-01	0.062
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.671826e-01	0.062
Acyl chain remodelling of PE	R-HSA-1482839	8.671826e-01	0.062
Transferrin endocytosis and recycling	R-HSA-917977	8.671826e-01	0.062
tRNA modification in the nucleus and cytosol	R-HSA-6782315	8.701305e-01	0.060
Lysosome Vesicle Biogenesis	R-HSA-432720	8.734238e-01	0.059
Calmodulin induced events	R-HSA-111933	8.734238e-01	0.059
CaM pathway	R-HSA-111997	8.734238e-01	0.059
Regulation of TP53 Degradation	R-HSA-6804757	8.734238e-01	0.059
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.793720e-01	0.056
NCAM1 interactions	R-HSA-419037	8.793720e-01	0.056
Metabolism of folate and pterines	R-HSA-196757	8.793720e-01	0.056
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.795706e-01	0.056
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.840494e-01	0.054
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.850411e-01	0.053
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.871830e-01	0.052
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.883735e-01	0.051
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.883735e-01	0.051
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.904441e-01	0.050
Hedgehog 'on' state	R-HSA-5632684	8.925477e-01	0.049
MHC class II antigen presentation	R-HSA-2132295	8.943119e-01	0.049
Regulation of insulin secretion	R-HSA-422356	8.944052e-01	0.048
Generation of second messenger molecules	R-HSA-202433	8.955934e-01	0.048
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.955934e-01	0.048
Glycogen metabolism	R-HSA-8982491	8.955934e-01	0.048
Nuclear signaling by ERBB4	R-HSA-1251985	8.955934e-01	0.048
Formation of the cornified envelope	R-HSA-6809371	8.974346e-01	0.047
Maturation of spike protein	R-HSA-9694548	9.005010e-01	0.046
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.005010e-01	0.046
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.005010e-01	0.046
SARS-CoV-1 Infection	R-HSA-9678108	9.033921e-01	0.044
Signaling by NOTCH4	R-HSA-9013694	9.042156e-01	0.044
ROS and RNS production in phagocytes	R-HSA-1222556	9.042156e-01	0.044
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.051782e-01	0.043
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.051782e-01	0.043
Intra-Golgi traffic	R-HSA-6811438	9.051782e-01	0.043
GABA B receptor activation	R-HSA-977444	9.096359e-01	0.041
Activation of GABAB receptors	R-HSA-991365	9.096359e-01	0.041
Ca-dependent events	R-HSA-111996	9.096359e-01	0.041
Interleukin-1 family signaling	R-HSA-446652	9.103614e-01	0.041
Interleukin-12 signaling	R-HSA-9020591	9.113250e-01	0.040
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.136440e-01	0.039
Opioid Signalling	R-HSA-111885	9.136440e-01	0.039
TBC/RABGAPs	R-HSA-8854214	9.138842e-01	0.039
Gap junction trafficking	R-HSA-190828	9.179330e-01	0.037
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.179330e-01	0.037
Surfactant metabolism	R-HSA-5683826	9.179330e-01	0.037
Integrin cell surface interactions	R-HSA-216083	9.179376e-01	0.037
Cholesterol biosynthesis	R-HSA-191273	9.179376e-01	0.037
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.217918e-01	0.035
Asymmetric localization of PCP proteins	R-HSA-4608870	9.217918e-01	0.035
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.217918e-01	0.035
DAG and IP3 signaling	R-HSA-1489509	9.217918e-01	0.035
Golgi-to-ER retrograde transport	R-HSA-8856688	9.244495e-01	0.034
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.254693e-01	0.034
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.254693e-01	0.034
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.271797e-01	0.033
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.271797e-01	0.033
Intraflagellar transport	R-HSA-5620924	9.323143e-01	0.030
Co-stimulation by CD28	R-HSA-389356	9.323143e-01	0.030
Metal ion SLC transporters	R-HSA-425410	9.323143e-01	0.030
Gap junction trafficking and regulation	R-HSA-157858	9.354976e-01	0.029
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.354976e-01	0.029
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.354976e-01	0.029
Chemokine receptors bind chemokines	R-HSA-380108	9.354976e-01	0.029
Vesicle-mediated transport	R-HSA-5653656	9.393457e-01	0.027
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.400214e-01	0.027
Activation of NF-kappaB in B cells	R-HSA-1169091	9.414226e-01	0.026
Complex IV assembly	R-HSA-9864848	9.414226e-01	0.026
Hedgehog ligand biogenesis	R-HSA-5358346	9.414226e-01	0.026
XBP1(S) activates chaperone genes	R-HSA-381038	9.423475e-01	0.026
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.431016e-01	0.025
Leishmania phagocytosis	R-HSA-9664417	9.431016e-01	0.025
Parasite infection	R-HSA-9664407	9.431016e-01	0.025
Neddylation	R-HSA-8951664	9.432465e-01	0.025
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.441780e-01	0.025
Post NMDA receptor activation events	R-HSA-438064	9.445878e-01	0.025
Chaperonin-mediated protein folding	R-HSA-390466	9.445878e-01	0.025
Interleukin-12 family signaling	R-HSA-447115	9.445878e-01	0.025
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.448915e-01	0.025
Macroautophagy	R-HSA-1632852	9.448915e-01	0.025
Peptide chain elongation	R-HSA-156902	9.467451e-01	0.024
Regulation of PTEN stability and activity	R-HSA-8948751	9.468040e-01	0.024
Amino acids regulate mTORC1	R-HSA-9639288	9.468040e-01	0.024
Smooth Muscle Contraction	R-HSA-445355	9.468040e-01	0.024
Eukaryotic Translation Initiation	R-HSA-72613	9.485882e-01	0.023
Cap-dependent Translation Initiation	R-HSA-72737	9.485882e-01	0.023
ER-Phagosome pathway	R-HSA-1236974	9.488222e-01	0.023
Translation initiation complex formation	R-HSA-72649	9.493066e-01	0.023
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.493066e-01	0.023
Rab regulation of trafficking	R-HSA-9007101	9.503716e-01	0.022
Class B/2 (Secretin family receptors)	R-HSA-373080	9.508220e-01	0.022
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.516916e-01	0.022
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.527470e-01	0.021
Transport to the Golgi and subsequent modification	R-HSA-948021	9.537794e-01	0.021
Ribosomal scanning and start codon recognition	R-HSA-72702	9.539646e-01	0.020
IRE1alpha activates chaperones	R-HSA-381070	9.545999e-01	0.020
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.550771e-01	0.020
Eukaryotic Translation Elongation	R-HSA-156842	9.563832e-01	0.019
Protein folding	R-HSA-391251	9.563832e-01	0.019
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.580994e-01	0.019
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.581950e-01	0.019
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.581950e-01	0.019
Mitochondrial protein degradation	R-HSA-9837999	9.597508e-01	0.018
Peroxisomal protein import	R-HSA-9033241	9.601623e-01	0.018
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.613398e-01	0.017
RAB geranylgeranylation	R-HSA-8873719	9.620372e-01	0.017
GABA receptor activation	R-HSA-977443	9.620372e-01	0.017
Glutathione conjugation	R-HSA-156590	9.620372e-01	0.017
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.620372e-01	0.017
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.628684e-01	0.016
Eukaryotic Translation Termination	R-HSA-72764	9.628684e-01	0.016
Formation of a pool of free 40S subunits	R-HSA-72689	9.628684e-01	0.016
Endogenous sterols	R-HSA-211976	9.638239e-01	0.016
PLC beta mediated events	R-HSA-112043	9.638239e-01	0.016
Protein localization	R-HSA-9609507	9.639096e-01	0.016
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.643389e-01	0.016
Potassium Channels	R-HSA-1296071	9.643389e-01	0.016
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.655266e-01	0.015
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.663520e-01	0.015
Cellular response to chemical stress	R-HSA-9711123	9.663551e-01	0.015
Platelet degranulation	R-HSA-114608	9.665240e-01	0.015
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.671493e-01	0.015
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.694424e-01	0.013
Cellular response to starvation	R-HSA-9711097	9.694424e-01	0.013
Cellular response to hypoxia	R-HSA-1234174	9.701694e-01	0.013
Interferon gamma signaling	R-HSA-877300	9.704494e-01	0.013
Selenocysteine synthesis	R-HSA-2408557	9.708903e-01	0.013
Platelet activation, signaling and aggregation	R-HSA-76002	9.713544e-01	0.013
Cardiac conduction	R-HSA-5576891	9.720954e-01	0.012
Nicotinate metabolism	R-HSA-196807	9.729122e-01	0.012
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.729122e-01	0.012
G-protein mediated events	R-HSA-112040	9.729122e-01	0.012
Viral mRNA Translation	R-HSA-192823	9.731718e-01	0.012
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.740680e-01	0.011
Parasitic Infection Pathways	R-HSA-9824443	9.763267e-01	0.010
Leishmania infection	R-HSA-9658195	9.763267e-01	0.010
Neuronal System	R-HSA-112316	9.764339e-01	0.010
Platelet homeostasis	R-HSA-418346	9.772281e-01	0.010
Integration of energy metabolism	R-HSA-163685	9.776233e-01	0.010
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.776652e-01	0.010
Metabolism of cofactors	R-HSA-8978934	9.776652e-01	0.010
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.781456e-01	0.010
Stimuli-sensing channels	R-HSA-2672351	9.790271e-01	0.009
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.796938e-01	0.009
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.797195e-01	0.009
Diseases of carbohydrate metabolism	R-HSA-5663084	9.797195e-01	0.009
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.803440e-01	0.009
C-type lectin receptors (CLRs)	R-HSA-5621481	9.810091e-01	0.008
Protein ubiquitination	R-HSA-8852135	9.815850e-01	0.008
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.815850e-01	0.008
Citric acid cycle (TCA cycle)	R-HSA-71403	9.815850e-01	0.008
Iron uptake and transport	R-HSA-917937	9.815850e-01	0.008
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.828793e-01	0.007
G alpha (q) signalling events	R-HSA-416476	9.829394e-01	0.007
Translation of Structural Proteins	R-HSA-9694635	9.832792e-01	0.007
Transmission across Chemical Synapses	R-HSA-112315	9.838294e-01	0.007
Phospholipid metabolism	R-HSA-1483257	9.839798e-01	0.007
ABC transporter disorders	R-HSA-5619084	9.840670e-01	0.007
SLC-mediated transport of organic anions	R-HSA-9955298	9.840670e-01	0.007
PCP/CE pathway	R-HSA-4086400	9.840670e-01	0.007
Disease	R-HSA-1643685	9.845415e-01	0.007
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.848177e-01	0.007
Immune System	R-HSA-168256	9.855603e-01	0.006
GPCR downstream signalling	R-HSA-388396	9.862646e-01	0.006
Muscle contraction	R-HSA-397014	9.867070e-01	0.006
Gastrulation	R-HSA-9758941	9.867521e-01	0.006
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.877198e-01	0.005
Peroxisomal lipid metabolism	R-HSA-390918	9.880734e-01	0.005
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.891712e-01	0.005
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.895246e-01	0.005
Ion channel transport	R-HSA-983712	9.898903e-01	0.004
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.906316e-01	0.004
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.909409e-01	0.004
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.924789e-01	0.003
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.926417e-01	0.003
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.926417e-01	0.003
Infectious disease	R-HSA-5663205	9.937478e-01	0.003
Glycerophospholipid biosynthesis	R-HSA-1483206	9.938887e-01	0.003
Cell surface interactions at the vascular wall	R-HSA-202733	9.942791e-01	0.002
Extracellular matrix organization	R-HSA-1474244	9.944244e-01	0.002
Keratinization	R-HSA-6805567	9.947173e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.947534e-01	0.002
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.949442e-01	0.002
Leishmania parasite growth and survival	R-HSA-9664433	9.949442e-01	0.002
Synthesis of bile acids and bile salts	R-HSA-192105	9.950009e-01	0.002
Ribosome-associated quality control	R-HSA-9948299	9.951801e-01	0.002
ABC-family proteins mediated transport	R-HSA-382556	9.952368e-01	0.002
Unfolded Protein Response (UPR)	R-HSA-381119	9.953818e-01	0.002
Respiratory electron transport	R-HSA-611105	9.958454e-01	0.002
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.969174e-01	0.001
Peptide ligand-binding receptors	R-HSA-375276	9.969722e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.972016e-01	0.001
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.972420e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.973338e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.973527e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.974702e-01	0.001
Signaling by GPCR	R-HSA-372790	9.975256e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.978029e-01	0.001
Hemostasis	R-HSA-109582	9.978390e-01	0.001
rRNA processing	R-HSA-72312	9.979888e-01	0.001
Neutrophil degranulation	R-HSA-6798695	9.981822e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.984970e-01	0.001
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.985082e-01	0.001
G alpha (i) signalling events	R-HSA-418594	9.986728e-01	0.001
Sensory perception of taste	R-HSA-9717189	9.991657e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.995117e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.995967e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.997264e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.997419e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.998679e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.998769e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999130e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999169e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999343e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999413e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999449e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999644e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999731e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999759e-01	0.000
Innate Immune System	R-HSA-168249	9.999804e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999821e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999896e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999964e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999974e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999984e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999995e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999999e-01	0.000
Translation	R-HSA-72766	9.999999e-01	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.110223e-16	15.955
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
HSF1-dependent transactivation	R-HSA-3371571	4.362510e-12	11.360
Attenuation phase	R-HSA-3371568	5.625167e-12	11.250
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.053766e-09	8.296
HSF1 activation	R-HSA-3371511	6.600890e-09	8.180
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	6.899027e-08	7.161
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.462534e-07	6.835
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.141200e-07	6.669
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.027204e-07	6.519
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.062620e-06	5.974
Cell Cycle, Mitotic	R-HSA-69278	1.110391e-06	5.955
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.870403e-06	5.728
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.967569e-06	5.706
Nuclear import of Rev protein	R-HSA-180746	1.974010e-06	5.705
Cellular responses to stress	R-HSA-2262752	2.243578e-06	5.649
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.595295e-06	5.586
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.595295e-06	5.586
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.607697e-06	5.584
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.561994e-06	5.448
Apoptotic execution phase	R-HSA-75153	4.085160e-06	5.389
Nuclear Envelope Breakdown	R-HSA-2980766	3.976093e-06	5.401
Cell Cycle	R-HSA-1640170	4.253884e-06	5.371
IPs transport between nucleus and cytosol	R-HSA-1855170	4.838403e-06	5.315
mRNA Splicing - Major Pathway	R-HSA-72163	4.880098e-06	5.312
M Phase	R-HSA-68886	6.221400e-06	5.206
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.507916e-06	5.187
Chromatin organization	R-HSA-4839726	6.838592e-06	5.165
Interactions of Rev with host cellular proteins	R-HSA-177243	1.062867e-05	4.974
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.145373e-05	4.941
PKMTs methylate histone lysines	R-HSA-3214841	1.369327e-05	4.863
mRNA Splicing	R-HSA-72172	1.570547e-05	4.804
Cellular responses to stimuli	R-HSA-8953897	1.684850e-05	4.773
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.948620e-05	4.710
Mitotic Anaphase	R-HSA-68882	2.419327e-05	4.616
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.511966e-05	4.600
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.662706e-05	4.575
Chromatin modifying enzymes	R-HSA-3247509	3.057333e-05	4.515
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.126948e-05	4.505
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.214396e-05	4.493
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.084344e-05	4.389
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.154808e-05	4.288
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.465969e-05	4.262
Mitotic Prophase	R-HSA-68875	6.742899e-05	4.171
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.781403e-05	4.109
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.060538e-05	4.043
Late Phase of HIV Life Cycle	R-HSA-162599	1.092759e-04	3.961
HIV Life Cycle	R-HSA-162587	1.096189e-04	3.960
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.505534e-04	3.822
Nervous system development	R-HSA-9675108	1.839438e-04	3.735
Transcriptional regulation by small RNAs	R-HSA-5578749	2.027573e-04	3.693
snRNP Assembly	R-HSA-191859	2.030588e-04	3.692
Metabolism of non-coding RNA	R-HSA-194441	2.030588e-04	3.692
Separation of Sister Chromatids	R-HSA-2467813	2.200944e-04	3.657
Viral Messenger RNA Synthesis	R-HSA-168325	2.834537e-04	3.548
ISG15 antiviral mechanism	R-HSA-1169408	3.175074e-04	3.498
tRNA processing in the nucleus	R-HSA-6784531	3.331092e-04	3.477
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.546891e-04	3.450
Signaling by ALK in cancer	R-HSA-9700206	3.546891e-04	3.450
Mitotic Prometaphase	R-HSA-68877	3.931250e-04	3.405
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.069881e-04	3.390
Axon guidance	R-HSA-422475	4.327316e-04	3.364
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.003170e-04	3.301
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.111686e-04	3.214
Recycling pathway of L1	R-HSA-437239	6.893807e-04	3.162
Mitotic Spindle Checkpoint	R-HSA-69618	7.619482e-04	3.118
Glycolysis	R-HSA-70171	7.619482e-04	3.118
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.190879e-04	3.087
Influenza Infection	R-HSA-168255	9.088232e-04	3.042
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.094789e-03	2.961
Signaling by Hippo	R-HSA-2028269	1.094789e-03	2.961
Metabolism of RNA	R-HSA-8953854	1.070933e-03	2.970
Cap-dependent Translation Initiation	R-HSA-72737	1.172037e-03	2.931
Eukaryotic Translation Initiation	R-HSA-72613	1.172037e-03	2.931
mTORC1-mediated signalling	R-HSA-166208	1.284882e-03	2.891
Amplification of signal from the kinetochores	R-HSA-141424	1.349398e-03	2.870
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.349398e-03	2.870
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.407347e-03	2.852
Transport of connexons to the plasma membrane	R-HSA-190872	1.444429e-03	2.840
PKR-mediated signaling	R-HSA-9833482	1.566324e-03	2.805
Aggrephagy	R-HSA-9646399	1.570479e-03	2.804
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.611083e-03	2.793
Membrane Trafficking	R-HSA-199991	1.630405e-03	2.788
HCMV Early Events	R-HSA-9609690	1.795790e-03	2.746
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.047593e-03	2.689
NGF-stimulated transcription	R-HSA-9031628	2.333067e-03	2.632
COPI-mediated anterograde transport	R-HSA-6807878	2.504782e-03	2.601
MTOR signalling	R-HSA-165159	2.588482e-03	2.587
Signaling by ROBO receptors	R-HSA-376176	2.946103e-03	2.531
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.598385e-03	2.444
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.666032e-03	2.436
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.877484e-03	2.411
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.138952e-03	2.383
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.188108e-03	2.378
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.188108e-03	2.378
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.589959e-03	2.338
Epigenetic regulation of gene expression	R-HSA-212165	4.591505e-03	2.338
Regulation of PTEN gene transcription	R-HSA-8943724	4.643643e-03	2.333
HIV Infection	R-HSA-162906	4.894226e-03	2.310
ALK mutants bind TKIs	R-HSA-9700645	5.262291e-03	2.279
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.262291e-03	2.279
Interleukin-12 signaling	R-HSA-9020591	5.379588e-03	2.269
Translation initiation complex formation	R-HSA-72649	5.384684e-03	2.269
Glucose metabolism	R-HSA-70326	5.475746e-03	2.262
Inositol phosphate metabolism	R-HSA-1483249	5.978573e-03	2.223
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.340627e-03	2.198
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.577511e-03	2.182
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.800236e-03	2.167
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.008630e-03	2.154
Gap junction trafficking and regulation	R-HSA-157858	7.093887e-03	2.149
Gene Silencing by RNA	R-HSA-211000	7.751747e-03	2.111
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.874723e-03	2.104
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.117337e-03	2.091
ATP-dependent chromatin remodelers	R-HSA-9932444	8.430737e-03	2.074
SWI/SNF chromatin remodelers	R-HSA-9932451	8.430737e-03	2.074
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	8.818893e-03	2.055
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.818893e-03	2.055
Selective autophagy	R-HSA-9663891	9.168925e-03	2.038
Gap junction trafficking	R-HSA-190828	9.363346e-03	2.029
L1CAM interactions	R-HSA-373760	9.802388e-03	2.009
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	9.817060e-03	2.008
mRNA 3'-end processing	R-HSA-72187	1.031957e-02	1.986
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.065692e-02	1.972
HCMV Infection	R-HSA-9609646	1.090839e-02	1.962
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.102262e-02	1.958
Autophagy	R-HSA-9612973	1.130508e-02	1.947
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.209499e-02	1.917
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.209499e-02	1.917
Signaling downstream of RAS mutants	R-HSA-9649948	1.209499e-02	1.917
Signaling by RAS mutants	R-HSA-6802949	1.209499e-02	1.917
Macroautophagy	R-HSA-1632852	1.214130e-02	1.916
RNA Polymerase II Transcription Termination	R-HSA-73856	1.229545e-02	1.910
Transcriptional regulation by RUNX1	R-HSA-8878171	1.268176e-02	1.897
Activation of RAC1	R-HSA-428540	1.289249e-02	1.890
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.468732e-02	1.833
Diseases of Telomere Maintenance	R-HSA-9673013	1.468732e-02	1.833
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.468732e-02	1.833
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.468732e-02	1.833
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.468732e-02	1.833
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.394534e-02	1.856
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.352409e-02	1.869
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.457775e-02	1.836
Interferon Signaling	R-HSA-913531	1.406245e-02	1.852
Clathrin-mediated endocytosis	R-HSA-8856828	1.485614e-02	1.828
Signal Transduction	R-HSA-162582	1.500703e-02	1.824
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.553204e-02	1.809
MAP2K and MAPK activation	R-HSA-5674135	1.605108e-02	1.794
Ribosomal scanning and start codon recognition	R-HSA-72702	1.625863e-02	1.789
NRAGE signals death through JNK	R-HSA-193648	1.625863e-02	1.789
Cell Cycle Checkpoints	R-HSA-69620	1.633627e-02	1.787
MHC class II antigen presentation	R-HSA-2132295	1.652626e-02	1.782
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.655225e-02	1.781
Formation of annular gap junctions	R-HSA-196025	1.903388e-02	1.720
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.855082e-02	1.732
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.875806e-02	1.727
Cellular Senescence	R-HSA-2559583	1.799709e-02	1.745
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.903388e-02	1.720
Interleukin-12 family signaling	R-HSA-447115	1.710001e-02	1.767
Signaling by NTRKs	R-HSA-166520	2.043176e-02	1.690
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.054992e-02	1.687
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.137065e-02	1.670
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.182847e-02	1.661
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.182847e-02	1.661
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.185429e-02	1.660
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.239350e-02	1.650
MITF-M-dependent gene expression	R-HSA-9856651	2.307265e-02	1.637
Kinesins	R-HSA-983189	2.447161e-02	1.611
DNA strand elongation	R-HSA-69190	2.505378e-02	1.601
Inactivation of CDC42 and RAC1	R-HSA-428543	2.513739e-02	1.600
Gap junction degradation	R-HSA-190873	2.513739e-02	1.600
TGFBR3 expression	R-HSA-9839394	2.519827e-02	1.599
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.580116e-02	1.588
Oncogenic MAPK signaling	R-HSA-6802957	2.625843e-02	1.581
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.692545e-02	1.570
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.856663e-02	1.544
Myogenesis	R-HSA-525793	2.918169e-02	1.535
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.918169e-02	1.535
Manipulation of host energy metabolism	R-HSA-9636667	3.113908e-02	1.507
Breakdown of the nuclear lamina	R-HSA-352238	3.113908e-02	1.507
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.229386e-02	1.491
Host Interactions of HIV factors	R-HSA-162909	3.135781e-02	1.504
SARS-CoV-2-host interactions	R-HSA-9705683	3.447176e-02	1.463
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.578204e-02	1.446
Gap junction assembly	R-HSA-190861	3.658137e-02	1.437
IkBA variant leads to EDA-ID	R-HSA-5603029	3.763585e-02	1.424
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.763585e-02	1.424
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.782772e-02	1.422
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.784077e-02	1.422
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.817755e-02	1.418
Signaling by RAF1 mutants	R-HSA-9656223	3.823158e-02	1.418
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.823158e-02	1.418
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.914095e-02	1.407
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.914095e-02	1.407
MITF-M-regulated melanocyte development	R-HSA-9730414	4.044509e-02	1.393
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.045111e-02	1.393
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.245452e-02	1.372
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.188077e-02	1.285
Activation of the pre-replicative complex	R-HSA-68962	4.928662e-02	1.307
Formation of RNA Pol II elongation complex	R-HSA-112382	5.151332e-02	1.288
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.758341e-02	1.323
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.940161e-02	1.306
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.741004e-02	1.324
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.983791e-02	1.302
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.783999e-02	1.320
Eukaryotic Translation Elongation	R-HSA-156842	5.091571e-02	1.293
Estrogen-dependent gene expression	R-HSA-9018519	4.510656e-02	1.346
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.019630e-02	1.299
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.062741e-02	1.296
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.983791e-02	1.302
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.971427e-02	1.304
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.188077e-02	1.285
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	5.218782e-02	1.282
ER to Golgi Anterograde Transport	R-HSA-199977	5.282425e-02	1.277
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.336855e-02	1.273
G alpha (12/13) signalling events	R-HSA-416482	5.544043e-02	1.256
RNA Polymerase I Transcription	R-HSA-73864	5.544043e-02	1.256
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.544043e-02	1.256
Golgi-to-ER retrograde transport	R-HSA-8856688	5.614122e-02	1.251
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.624238e-02	1.250
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.624238e-02	1.250
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.624238e-02	1.250
XBP1(S) activates chaperone genes	R-HSA-381038	5.697044e-02	1.244
Regulation of endogenous retroelements	R-HSA-9842860	5.878817e-02	1.231
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.957148e-02	1.225
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.022471e-02	1.220
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.022471e-02	1.220
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.138760e-02	1.212
Diseases of mitotic cell cycle	R-HSA-9675126	6.198456e-02	1.208
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.283569e-02	1.202
RUNX3 regulates WNT signaling	R-HSA-8951430	6.452204e-02	1.190
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.452204e-02	1.190
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.452204e-02	1.190
Cohesin Loading onto Chromatin	R-HSA-2470946	6.452204e-02	1.190
SOS-mediated signalling	R-HSA-112412	6.452204e-02	1.190
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.452204e-02	1.190
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.166547e-02	1.145
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.166547e-02	1.145
HDACs deacetylate histones	R-HSA-3214815	6.653279e-02	1.177
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.210042e-02	1.142
Formation of a pool of free 40S subunits	R-HSA-72689	6.585917e-02	1.181
Nucleotide Excision Repair	R-HSA-5696398	7.444729e-02	1.128
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.522845e-02	1.124
HDMs demethylate histones	R-HSA-3214842	6.687776e-02	1.175
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.920568e-02	1.160
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	7.001032e-02	1.155
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.595690e-02	1.119
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.670155e-02	1.176
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.901606e-02	1.161
Death Receptor Signaling	R-HSA-73887	7.436415e-02	1.129
Apoptosis	R-HSA-109581	6.999720e-02	1.155
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	7.690998e-02	1.114
Invadopodia formation	R-HSA-8941237	7.690998e-02	1.114
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	7.690998e-02	1.114
Signaling by MRAS-complex mutants	R-HSA-9660537	8.050144e-02	1.094
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.050144e-02	1.094
TCF dependent signaling in response to WNT	R-HSA-201681	8.059510e-02	1.094
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.081314e-02	1.093
Formation of definitive endoderm	R-HSA-9823730	8.081314e-02	1.093
IRE1alpha activates chaperones	R-HSA-381070	8.344264e-02	1.079
HATs acetylate histones	R-HSA-3214847	8.348926e-02	1.078
p75 NTR receptor-mediated signalling	R-HSA-193704	8.348926e-02	1.078
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.412884e-02	1.075
Retrograde neurotrophin signalling	R-HSA-177504	8.412884e-02	1.075
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.414354e-02	1.075
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.414354e-02	1.075
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	8.702042e-02	1.060
Lagging Strand Synthesis	R-HSA-69186	9.161548e-02	1.038
Transcription of the HIV genome	R-HSA-167172	9.236889e-02	1.034
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.236889e-02	1.034
HIV elongation arrest and recovery	R-HSA-167287	9.361619e-02	1.029
Pausing and recovery of HIV elongation	R-HSA-167290	9.361619e-02	1.029
Regulation of TP53 Activity	R-HSA-5633007	9.703024e-02	1.013
Developmental Biology	R-HSA-1266738	9.747841e-02	1.011
Processive synthesis on the lagging strand	R-HSA-69183	9.757368e-02	1.011
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	9.757368e-02	1.011
WNT mediated activation of DVL	R-HSA-201688	9.800368e-02	1.009
Unwinding of DNA	R-HSA-176974	9.800368e-02	1.009
Vesicle-mediated transport	R-HSA-5653656	9.810319e-02	1.008
Oxidative Stress Induced Senescence	R-HSA-2559580	9.852931e-02	1.006
Mitotic G2-G2/M phases	R-HSA-453274	9.861684e-02	1.006
Regulation of gap junction activity	R-HSA-191650	1.045077e-01	0.981
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.045077e-01	0.981
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.045077e-01	0.981
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.168851e-01	0.932
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.031200e-01	0.987
mRNA Splicing - Minor Pathway	R-HSA-72165	1.244039e-01	0.905
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.244039e-01	0.905
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.954082e-02	1.002
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.166748e-01	0.933
Chromosome Maintenance	R-HSA-73886	1.168814e-01	0.932
Apoptosis induced DNA fragmentation	R-HSA-140342	1.168851e-01	0.932
PI3K/AKT activation	R-HSA-198203	1.168851e-01	0.932
Peptide chain elongation	R-HSA-156902	1.116050e-01	0.952
Signal attenuation	R-HSA-74749	1.168851e-01	0.932
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.045077e-01	0.981
Negative regulation of FLT3	R-HSA-9706369	1.119505e-01	0.951
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.161433e-01	0.935
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.161433e-01	0.935
Post NMDA receptor activation events	R-HSA-438064	1.054697e-01	0.977
Signaling by PDGFR in disease	R-HSA-9671555	1.031200e-01	0.987
Josephin domain DUBs	R-HSA-5689877	1.168851e-01	0.932
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.053264e-01	0.977
Signaling by TGFBR3	R-HSA-9839373	1.244039e-01	0.905
RET signaling	R-HSA-8853659	1.016963e-01	0.993
Signaling by Leptin	R-HSA-2586552	1.168851e-01	0.932
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.244904e-01	0.905
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.266445e-01	0.897
HCMV Late Events	R-HSA-9610379	1.268291e-01	0.897
Adipogenesis	R-HSA-9843745	1.307883e-01	0.883
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.308490e-01	0.883
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.312373e-01	0.882
G2/M Transition	R-HSA-69275	1.313829e-01	0.881
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.325064e-01	0.878
IRS activation	R-HSA-74713	1.342941e-01	0.872
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.342941e-01	0.872
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.342941e-01	0.872
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.403029e-01	0.853
HIV Transcription Elongation	R-HSA-167169	1.414013e-01	0.850
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.414013e-01	0.850
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.414013e-01	0.850
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.414013e-01	0.850
TRAF6 mediated NF-kB activation	R-HSA-933542	1.415862e-01	0.849
Deadenylation of mRNA	R-HSA-429947	1.415862e-01	0.849
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.415862e-01	0.849
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.415862e-01	0.849
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.420809e-01	0.847
Centrosome maturation	R-HSA-380287	1.420809e-01	0.847
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.432691e-01	0.844
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.439419e-01	0.842
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.664730e-01	0.779
MGMT-mediated DNA damage reversal	R-HSA-5657655	1.664730e-01	0.779
Interactions of Tat with host cellular proteins	R-HSA-176034	2.390155e-01	0.622
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.390155e-01	0.622
IKBKB deficiency causes SCID	R-HSA-5602636	2.390155e-01	0.622
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.390155e-01	0.622
Signaling by TCF7L2 mutants	R-HSA-5339700	2.390155e-01	0.622
Defective VWF binding to collagen type I	R-HSA-9845622	2.390155e-01	0.622
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.390155e-01	0.622
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.390155e-01	0.622
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.656799e-01	0.781
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.052485e-01	0.515
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.052485e-01	0.515
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.052485e-01	0.515
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.052485e-01	0.515
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.052485e-01	0.515
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.052485e-01	0.515
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.052485e-01	0.515
Signaling by LTK in cancer	R-HSA-9842640	1.981616e-01	0.703
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.581775e-01	0.801
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.581775e-01	0.801
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	2.313111e-01	0.636
Recycling of eIF2:GDP	R-HSA-72731	2.313111e-01	0.636
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	2.313111e-01	0.636
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.657204e-01	0.437
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.657204e-01	0.437
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	3.657204e-01	0.437
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.657204e-01	0.437
RUNX3 regulates p14-ARF	R-HSA-8951936	1.802792e-01	0.744
Repression of WNT target genes	R-HSA-4641265	1.802792e-01	0.744
Leading Strand Synthesis	R-HSA-69109	1.802792e-01	0.744
Polymerase switching	R-HSA-69091	1.802792e-01	0.744
Type I hemidesmosome assembly	R-HSA-446107	2.647667e-01	0.577
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.647667e-01	0.577
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.031480e-01	0.692
Formation of axial mesoderm	R-HSA-9796292	2.031480e-01	0.692
Ephrin signaling	R-HSA-3928664	1.600827e-01	0.796
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.600827e-01	0.796
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.775743e-01	0.751
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.266367e-01	0.645
Removal of the Flap Intermediate	R-HSA-69166	2.266367e-01	0.645
GP1b-IX-V activation signalling	R-HSA-430116	2.982242e-01	0.525
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.982242e-01	0.525
Lipophagy	R-HSA-9613354	2.982242e-01	0.525
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	2.982242e-01	0.525
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.209320e-01	0.376
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.209320e-01	0.376
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.209320e-01	0.376
Binding and entry of HIV virion	R-HSA-173107	3.314302e-01	0.480
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.614125e-01	0.792
Phosphorylation of the APC/C	R-HSA-176412	2.749194e-01	0.561
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.749194e-01	0.561
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.008348e-01	0.697
Formation of the Early Elongation Complex	R-HSA-113418	2.008348e-01	0.697
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.636770e-01	0.786
HIV Transcription Initiation	R-HSA-167161	1.636770e-01	0.786
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.636770e-01	0.786
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.994554e-01	0.524
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.641750e-01	0.439
G2 Phase	R-HSA-68911	4.713407e-01	0.327
FLT3 signaling by CBL mutants	R-HSA-9706377	4.713407e-01	0.327
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.713407e-01	0.327
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.713407e-01	0.327
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.713407e-01	0.327
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.726842e-01	0.564
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.726842e-01	0.564
RNA Polymerase II Promoter Escape	R-HSA-73776	1.874048e-01	0.727
EGFR downregulation	R-HSA-182971	2.498361e-01	0.602
Signaling by AXIN mutants	R-HSA-4839735	3.962876e-01	0.402
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.124374e-01	0.673
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.668071e-01	0.574
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.129688e-01	0.504
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.386125e-01	0.622
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.037393e-01	0.691
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.037393e-01	0.691
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.014402e-01	0.521
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.732808e-01	0.428
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.276302e-01	0.369
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.173640e-01	0.286
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.173640e-01	0.286
Plus-strand DNA synthesis	R-HSA-164525	5.173640e-01	0.286
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.173640e-01	0.286
Noncanonical activation of NOTCH3	R-HSA-9017802	5.173640e-01	0.286
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.173640e-01	0.286
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.173640e-01	0.286
Signaling by MAPK mutants	R-HSA-9652817	5.173640e-01	0.286
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.679128e-01	0.775
RAF activation	R-HSA-5673000	3.190158e-01	0.496
Dual Incision in GG-NER	R-HSA-5696400	3.190158e-01	0.496
AURKA Activation by TPX2	R-HSA-8854518	2.369409e-01	0.625
Dual incision in TC-NER	R-HSA-6782135	2.569198e-01	0.590
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.537290e-01	0.451
Interaction between L1 and Ankyrins	R-HSA-445095	3.537290e-01	0.451
Transcriptional regulation by RUNX3	R-HSA-8878159	1.921441e-01	0.716
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.976369e-01	0.401
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.580934e-01	0.339
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.580934e-01	0.339
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.580934e-01	0.339
RNA Polymerase I Promoter Escape	R-HSA-73772	3.078993e-01	0.512
PRC2 methylates histones and DNA	R-HSA-212300	3.544760e-01	0.450
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.838845e-01	0.547
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.217273e-01	0.375
DNA methylation	R-HSA-5334118	3.944883e-01	0.404
Late endosomal microautophagy	R-HSA-9615710	3.944883e-01	0.404
Viral mRNA Translation	R-HSA-192823	2.450126e-01	0.611
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.147332e-01	0.382
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.593831e-01	0.252
Erythropoietin activates STAT5	R-HSA-9027283	5.593831e-01	0.252
Uncoating of the HIV Virion	R-HSA-162585	5.593831e-01	0.252
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.012912e-01	0.397
FGFR2 alternative splicing	R-HSA-6803529	4.688374e-01	0.329
Notch-HLH transcription pathway	R-HSA-350054	4.688374e-01	0.329
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.255459e-01	0.371
Erythropoietin activates RAS	R-HSA-9027284	5.160659e-01	0.287
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.160659e-01	0.287
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.431373e-01	0.353
Striated Muscle Contraction	R-HSA-390522	4.937508e-01	0.306
Translesion synthesis by POLI	R-HSA-5656121	5.434673e-01	0.265
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.128228e-01	0.290
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.559544e-01	0.341
Translesion synthesis by POLK	R-HSA-5655862	5.697681e-01	0.244
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.808692e-01	0.318
Nuclear Receptor transcription pathway	R-HSA-383280	5.232918e-01	0.281
Condensation of Prophase Chromosomes	R-HSA-2299718	5.449385e-01	0.264
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.449385e-01	0.264
EPHA-mediated growth cone collapse	R-HSA-3928663	5.779997e-01	0.238
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	1.636770e-01	0.786
Integrin signaling	R-HSA-354192	2.840230e-01	0.547
EPH-Ephrin signaling	R-HSA-2682334	3.281321e-01	0.484
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.331542e-01	0.632
mRNA Capping	R-HSA-72086	3.944883e-01	0.404
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.988710e-01	0.399
Ribosome-associated quality control	R-HSA-9948299	4.413863e-01	0.355
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.988710e-01	0.399
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.988710e-01	0.399
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.802792e-01	0.744
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.217273e-01	0.375
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.610609e-01	0.251
Telomere Maintenance	R-HSA-157579	1.921441e-01	0.716
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.190158e-01	0.496
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.598775e-01	0.337
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.331542e-01	0.632
Extension of Telomeres	R-HSA-180786	2.695811e-01	0.569
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.779997e-01	0.238
DNA Damage Bypass	R-HSA-73893	4.172609e-01	0.380
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.533249e-01	0.452
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.695811e-01	0.569
Frs2-mediated activation	R-HSA-170968	4.580934e-01	0.339
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.978834e-01	0.303
Chaperonin-mediated protein folding	R-HSA-390466	1.718782e-01	0.765
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.147332e-01	0.382
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.160659e-01	0.287
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.994554e-01	0.524
UCH proteinases	R-HSA-5689603	2.402699e-01	0.619
Regulation of CDH11 function	R-HSA-9762292	3.314302e-01	0.480
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.749194e-01	0.561
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	3.962876e-01	0.402
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.596498e-01	0.586
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.950763e-01	0.403
Translesion synthesis by REV1	R-HSA-110312	5.160659e-01	0.287
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.679137e-01	0.246
Chaperone Mediated Autophagy	R-HSA-9613829	3.487382e-01	0.458
Protein folding	R-HSA-391251	2.250232e-01	0.648
Synthesis of DNA	R-HSA-69239	2.927762e-01	0.533
VLDLR internalisation and degradation	R-HSA-8866427	1.802792e-01	0.744
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.802792e-01	0.744
Adrenoceptors	R-HSA-390696	2.647667e-01	0.577
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.014580e-01	0.696
Budding and maturation of HIV virion	R-HSA-162588	2.498361e-01	0.602
NF-kB is activated and signals survival	R-HSA-209560	3.962876e-01	0.402
Translesion Synthesis by POLH	R-HSA-110320	3.732808e-01	0.428
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.844572e-01	0.546
RNA Polymerase I Transcription Termination	R-HSA-73863	5.779997e-01	0.238
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	1.701999e-01	0.769
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.345177e-01	0.362
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.637673e-01	0.579
Activation of HOX genes during differentiation	R-HSA-5619507	2.637673e-01	0.579
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.276302e-01	0.369
NoRC negatively regulates rRNA expression	R-HSA-427413	2.960065e-01	0.529
Cellular response to starvation	R-HSA-9711097	1.882015e-01	0.725
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.128228e-01	0.290
Deadenylation-dependent mRNA decay	R-HSA-429914	2.695811e-01	0.569
DNA Double-Strand Break Repair	R-HSA-5693532	4.901623e-01	0.310
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.877191e-01	0.726
Early Phase of HIV Life Cycle	R-HSA-162594	4.217273e-01	0.375
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.454815e-01	0.351
DNA Double Strand Break Response	R-HSA-5693606	3.756040e-01	0.425
Prolonged ERK activation events	R-HSA-169893	5.434673e-01	0.265
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.656799e-01	0.781
Calcineurin activates NFAT	R-HSA-2025928	2.982242e-01	0.525
Negative regulation of MET activity	R-HSA-6807004	1.956726e-01	0.708
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.743616e-01	0.759
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.713407e-01	0.327
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.331542e-01	0.632
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.240973e-01	0.489
Activation of ATR in response to replication stress	R-HSA-176187	2.840230e-01	0.547
Intraflagellar transport	R-HSA-5620924	2.520747e-01	0.598
Defective pyroptosis	R-HSA-9710421	3.215717e-01	0.493
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.434673e-01	0.265
Killing mechanisms	R-HSA-9664420	5.434673e-01	0.265
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.705461e-01	0.244
Processing of DNA double-strand break ends	R-HSA-5693607	5.616690e-01	0.251
Homology Directed Repair	R-HSA-5693538	5.408398e-01	0.267
Circadian clock	R-HSA-9909396	2.790647e-01	0.554
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.580934e-01	0.339
DNA Replication Pre-Initiation	R-HSA-69002	2.194694e-01	0.659
Meiosis	R-HSA-1500620	3.424950e-01	0.465
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.160659e-01	0.287
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.573045e-01	0.254
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.209320e-01	0.376
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.209320e-01	0.376
Cell-extracellular matrix interactions	R-HSA-446353	2.506049e-01	0.601
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.713407e-01	0.327
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.173640e-01	0.286
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.173640e-01	0.286
Eukaryotic Translation Termination	R-HSA-72764	1.758127e-01	0.755
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.593831e-01	0.252
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.593831e-01	0.252
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.688374e-01	0.329
Switching of origins to a post-replicative state	R-HSA-69052	4.569947e-01	0.340
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.779997e-01	0.238
Signaling by NOTCH3	R-HSA-9012852	5.111907e-01	0.291
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.614125e-01	0.792
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.716496e-01	0.566
Signaling by EGFR	R-HSA-177929	2.321853e-01	0.634
Signaling by WNT	R-HSA-195721	4.471247e-01	0.350
Neurexins and neuroligins	R-HSA-6794361	1.855382e-01	0.732
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.523491e-01	0.817
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.962876e-01	0.402
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.160659e-01	0.287
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.160659e-01	0.287
DNA Replication	R-HSA-69306	3.909970e-01	0.408
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.994554e-01	0.524
S Phase	R-HSA-69242	1.874762e-01	0.727
p75NTR signals via NF-kB	R-HSA-193639	5.160659e-01	0.287
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.543268e-01	0.595
Signalling to ERKs	R-HSA-187687	5.315575e-01	0.274
Protein-protein interactions at synapses	R-HSA-6794362	2.324761e-01	0.634
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.045379e-01	0.689
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.276894e-01	0.278
Formation of editosomes by ADAR proteins	R-HSA-77042	1.664730e-01	0.779
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.390155e-01	0.622
Transport of connexins along the secretory pathway	R-HSA-190827	2.390155e-01	0.622
mRNA Editing: A to I Conversion	R-HSA-75064	3.052485e-01	0.515
Regulation of cortical dendrite branching	R-HSA-8985801	3.052485e-01	0.515
C6 deamination of adenosine	R-HSA-75102	3.052485e-01	0.515
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.981616e-01	0.703
MET interacts with TNS proteins	R-HSA-8875513	3.657204e-01	0.437
Signaling by LTK	R-HSA-9842663	1.802792e-01	0.744
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.647667e-01	0.577
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.314302e-01	0.480
Platelet calcium homeostasis	R-HSA-418360	2.168057e-01	0.664
Disorders of Developmental Biology	R-HSA-9675151	2.994554e-01	0.524
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.994554e-01	0.524
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.713407e-01	0.327
Reelin signalling pathway	R-HSA-8866376	4.713407e-01	0.327
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.713407e-01	0.327
Interleukin receptor SHC signaling	R-HSA-912526	2.726842e-01	0.564
RMTs methylate histone arginines	R-HSA-3214858	1.997679e-01	0.699
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.931235e-01	0.714
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.988657e-01	0.701
Synthesis of PS	R-HSA-1483101	5.173640e-01	0.286
RNA Polymerase I Promoter Opening	R-HSA-73728	3.537290e-01	0.451
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.580934e-01	0.339
G2/M DNA replication checkpoint	R-HSA-69478	5.593831e-01	0.252
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.160659e-01	0.287
Meiotic recombination	R-HSA-912446	4.490202e-01	0.348
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.647632e-01	0.333
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.434673e-01	0.265
Metalloprotease DUBs	R-HSA-5689901	5.573045e-01	0.254
Lysosome Vesicle Biogenesis	R-HSA-432720	5.499288e-01	0.260
Assembly of the pre-replicative complex	R-HSA-68867	3.392895e-01	0.469
Negative regulation of MAPK pathway	R-HSA-5675221	2.902665e-01	0.537
Cell junction organization	R-HSA-446728	1.958824e-01	0.708
Signaling by FGFR4 in disease	R-HSA-5655291	4.875930e-01	0.312
Signaling by VEGF	R-HSA-194138	2.986096e-01	0.525
Regulation of TNFR1 signaling	R-HSA-5357905	3.692967e-01	0.433
Cellular responses to mechanical stimuli	R-HSA-9855142	4.769832e-01	0.321
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.722806e-01	0.429
G2/M Checkpoints	R-HSA-69481	5.293603e-01	0.276
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.840230e-01	0.547
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.732808e-01	0.428
Spry regulation of FGF signaling	R-HSA-1295596	5.160659e-01	0.287
PERK regulates gene expression	R-HSA-381042	5.315575e-01	0.274
ESR-mediated signaling	R-HSA-8939211	3.967959e-01	0.401
Adherens junctions interactions	R-HSA-418990	2.001030e-01	0.699
Regulation of NPAS4 gene transcription	R-HSA-9768777	2.982242e-01	0.525
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.697681e-01	0.244
Cell-cell junction organization	R-HSA-421270	3.448284e-01	0.462
MAP kinase activation	R-HSA-450294	4.389417e-01	0.358
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.960065e-01	0.529
Cell-Cell communication	R-HSA-1500931	2.329621e-01	0.633
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.713407e-01	0.327
Selenocysteine synthesis	R-HSA-2408557	1.495140e-01	0.825
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.944883e-01	0.404
Neurofascin interactions	R-HSA-447043	5.593831e-01	0.252
Coenzyme A biosynthesis	R-HSA-196783	5.697681e-01	0.244
Acetylcholine regulates insulin secretion	R-HSA-399997	5.697681e-01	0.244
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.328266e-01	0.273
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.328266e-01	0.273
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.328266e-01	0.273
Cilium Assembly	R-HSA-5617833	2.756155e-01	0.560
DCC mediated attractive signaling	R-HSA-418885	2.506049e-01	0.601
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.741365e-01	0.427
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.520747e-01	0.598
Gene expression (Transcription)	R-HSA-74160	3.622030e-01	0.441
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.564737e-01	0.591
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.656799e-01	0.781
CHL1 interactions	R-HSA-447041	2.313111e-01	0.636
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.031480e-01	0.692
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.276302e-01	0.369
Pervasive developmental disorders	R-HSA-9005895	4.276302e-01	0.369
Disorders of Nervous System Development	R-HSA-9697154	4.276302e-01	0.369
Heme signaling	R-HSA-9707616	3.085315e-01	0.511
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.852944e-01	0.414
Interleukin-17 signaling	R-HSA-448424	5.656250e-01	0.247
TNF signaling	R-HSA-75893	3.657958e-01	0.437
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.566238e-01	0.805
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.321853e-01	0.634
Signaling by MET	R-HSA-6806834	2.844572e-01	0.546
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.313111e-01	0.636
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.276302e-01	0.369
Smooth Muscle Contraction	R-HSA-445355	3.222357e-01	0.492
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.875930e-01	0.312
Downstream signal transduction	R-HSA-186763	4.348239e-01	0.362
Acyl chain remodelling of PS	R-HSA-1482801	5.360107e-01	0.271
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.921441e-01	0.716
Base Excision Repair	R-HSA-73884	5.464509e-01	0.262
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.348239e-01	0.362
Organelle biogenesis and maintenance	R-HSA-1852241	3.791881e-01	0.421
Ion homeostasis	R-HSA-5578775	5.263358e-01	0.279
Deubiquitination	R-HSA-5688426	4.499407e-01	0.347
RUNX2 regulates bone development	R-HSA-8941326	3.544760e-01	0.450
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.803754e-01	0.420
Oligomerization of connexins into connexons	R-HSA-190704	2.390155e-01	0.622
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.581775e-01	0.801
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.852853e-01	0.732
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.994554e-01	0.524
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.240973e-01	0.489
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.931235e-01	0.714
Signalling to p38 via RIT and RIN	R-HSA-187706	5.173640e-01	0.286
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.366787e-01	0.473
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.307015e-01	0.481
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.547166e-01	0.342
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.160659e-01	0.287
Effects of PIP2 hydrolysis	R-HSA-114508	4.937508e-01	0.306
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.944883e-01	0.404
Transcriptional Regulation by VENTX	R-HSA-8853884	2.748569e-01	0.561
Nephrin family interactions	R-HSA-373753	3.976369e-01	0.401
PTEN Regulation	R-HSA-6807070	2.610377e-01	0.583
Transcriptional Regulation by E2F6	R-HSA-8953750	2.446760e-01	0.611
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.240973e-01	0.489
Protein hydroxylation	R-HSA-9629569	3.976369e-01	0.401
VxPx cargo-targeting to cilium	R-HSA-5620916	3.976369e-01	0.401
Basigin interactions	R-HSA-210991	4.217273e-01	0.375
Transport to the Golgi and subsequent modification	R-HSA-948021	3.659299e-01	0.437
Reproduction	R-HSA-1474165	5.692056e-01	0.245
Gluconeogenesis	R-HSA-70263	5.768908e-01	0.239
Signaling by TGFB family members	R-HSA-9006936	2.740212e-01	0.562
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.778890e-01	0.321
Histamine receptors	R-HSA-390650	3.657204e-01	0.437
Regulation of CDH11 gene transcription	R-HSA-9762293	2.982242e-01	0.525
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.528825e-01	0.597
PECAM1 interactions	R-HSA-210990	3.641750e-01	0.439
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.608942e-01	0.793
Tie2 Signaling	R-HSA-210993	3.487382e-01	0.458
Ovarian tumor domain proteases	R-HSA-5689896	3.722806e-01	0.429
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.743711e-01	0.324
TBC/RABGAPs	R-HSA-8854214	4.949941e-01	0.305
Hedgehog 'off' state	R-HSA-5610787	5.556491e-01	0.255
The NLRP3 inflammasome	R-HSA-844456	3.732808e-01	0.428
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.600827e-01	0.796
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.662770e-01	0.436
FLT3 signaling in disease	R-HSA-9682385	5.499288e-01	0.260
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.533249e-01	0.452
Signaling by PDGF	R-HSA-186797	4.534711e-01	0.343
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.052485e-01	0.515
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.313111e-01	0.636
Regulation of KIT signaling	R-HSA-1433559	2.266367e-01	0.645
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.982242e-01	0.525
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.749194e-01	0.561
NrCAM interactions	R-HSA-447038	4.713407e-01	0.327
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.840230e-01	0.547
CLEC7A/inflammasome pathway	R-HSA-5660668	5.173640e-01	0.286
CREB phosphorylation	R-HSA-199920	5.593831e-01	0.252
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.078508e-01	0.389
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.949941e-01	0.305
G2/M DNA damage checkpoint	R-HSA-69473	4.704312e-01	0.328
Viral Infection Pathways	R-HSA-9824446	2.686646e-01	0.571
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.616690e-01	0.251
Signaling by ALK	R-HSA-201556	2.446760e-01	0.611
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.749194e-01	0.561
Mismatch Repair	R-HSA-5358508	3.487382e-01	0.458
Zygotic genome activation (ZGA)	R-HSA-9819196	4.217273e-01	0.375
Programmed Cell Death	R-HSA-5357801	1.835034e-01	0.736
Sensory processing of sound	R-HSA-9659379	2.731883e-01	0.564
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.927353e-01	0.534
Neurodegenerative Diseases	R-HSA-8863678	2.927353e-01	0.534
Transcriptional Regulation by TP53	R-HSA-3700989	2.535215e-01	0.596
Maturation of nucleoprotein	R-HSA-9683610	4.580934e-01	0.339
Protein methylation	R-HSA-8876725	5.160659e-01	0.287
Collagen chain trimerization	R-HSA-8948216	3.722806e-01	0.429
PI Metabolism	R-HSA-1483255	4.529939e-01	0.344
STING mediated induction of host immune responses	R-HSA-1834941	3.732808e-01	0.428
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.537290e-01	0.451
Netrin-1 signaling	R-HSA-373752	5.118855e-01	0.291
Signaling by SCF-KIT	R-HSA-1433557	4.949941e-01	0.305
Interleukin-1 processing	R-HSA-448706	2.982242e-01	0.525
Formation of intermediate mesoderm	R-HSA-9761174	3.314302e-01	0.480
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.487382e-01	0.458
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.173640e-01	0.286
LDL clearance	R-HSA-8964038	4.688374e-01	0.329
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.160659e-01	0.287
Syndecan interactions	R-HSA-3000170	4.917408e-01	0.308
Diseases of programmed cell death	R-HSA-9645723	3.902398e-01	0.409
SARS-CoV-1-host interactions	R-HSA-9692914	2.829992e-01	0.548
FLT3 Signaling	R-HSA-9607240	4.431373e-01	0.353
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.600827e-01	0.796
Cytokine Signaling in Immune system	R-HSA-1280215	1.543843e-01	0.811
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.890279e-01	0.723
Regulation of gene expression in beta cells	R-HSA-210745	2.168057e-01	0.664
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.173640e-01	0.286
tRNA processing	R-HSA-72306	2.078627e-01	0.682
Interleukin-7 signaling	R-HSA-1266695	1.556203e-01	0.808
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.919933e-01	0.535
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.173640e-01	0.286
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.593831e-01	0.252
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.160659e-01	0.287
TRP channels	R-HSA-3295583	5.573045e-01	0.254
Unfolded Protein Response (UPR)	R-HSA-381119	1.864976e-01	0.729
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.321853e-01	0.634
Pre-NOTCH Processing in Golgi	R-HSA-1912420	3.732808e-01	0.428
SARS-CoV-2 Infection	R-HSA-9694516	1.936853e-01	0.713
Regulation of beta-cell development	R-HSA-186712	2.695811e-01	0.569
SARS-CoV Infections	R-HSA-9679506	2.789968e-01	0.554
SARS-CoV-1 Infection	R-HSA-9678108	4.997886e-01	0.301
SLC transporter disorders	R-HSA-5619102	3.301575e-01	0.481
Growth hormone receptor signaling	R-HSA-982772	4.917408e-01	0.308
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	4.688374e-01	0.329
Signaling by ERBB2	R-HSA-1227986	5.848278e-01	0.233
MET promotes cell motility	R-HSA-8875878	5.854923e-01	0.232
Selenoamino acid metabolism	R-HSA-2408522	5.894028e-01	0.230
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.924132e-01	0.227
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.949521e-01	0.226
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.949521e-01	0.226
Regulation of NPAS4 gene expression	R-HSA-9768759	5.949521e-01	0.226
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.949521e-01	0.226
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.949521e-01	0.226
Uptake and function of anthrax toxins	R-HSA-5210891	5.949521e-01	0.226
Specification of primordial germ cells	R-HSA-9827857	5.949521e-01	0.226
IFNG signaling activates MAPKs	R-HSA-9732724	5.977462e-01	0.223
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.977462e-01	0.223
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	5.977462e-01	0.223
NOSTRIN mediated eNOS trafficking	R-HSA-203641	5.977462e-01	0.223
PTK6 Expression	R-HSA-8849473	5.977462e-01	0.223
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.977462e-01	0.223
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.977462e-01	0.223
VLDL clearance	R-HSA-8964046	5.977462e-01	0.223
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.977462e-01	0.223
Regulation of PTEN localization	R-HSA-8948747	5.977462e-01	0.223
Cation-coupled Chloride cotransporters	R-HSA-426117	5.977462e-01	0.223
Uptake and function of diphtheria toxin	R-HSA-5336415	5.977462e-01	0.223
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	5.977462e-01	0.223
Maturation of replicase proteins	R-HSA-9694301	5.977462e-01	0.223
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.980748e-01	0.223
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.980748e-01	0.223
Inflammasomes	R-HSA-622312	5.980748e-01	0.223
IRS-related events triggered by IGF1R	R-HSA-2428928	5.988614e-01	0.223
Response of endothelial cells to shear stress	R-HSA-9860931	5.998895e-01	0.222
Plasma lipoprotein clearance	R-HSA-8964043	6.026477e-01	0.220
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.092045e-01	0.215
Signaling by Interleukins	R-HSA-449147	6.136979e-01	0.212
Co-inhibition by PD-1	R-HSA-389948	6.144177e-01	0.212
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.160421e-01	0.210
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.161015e-01	0.210
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.175136e-01	0.209
Termination of translesion DNA synthesis	R-HSA-5656169	6.175136e-01	0.209
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.175136e-01	0.209
Synaptic adhesion-like molecules	R-HSA-8849932	6.190144e-01	0.208
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.190144e-01	0.208
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.190144e-01	0.208
Polo-like kinase mediated events	R-HSA-156711	6.190144e-01	0.208
Nephron development	R-HSA-9831926	6.190144e-01	0.208
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.190144e-01	0.208
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.193658e-01	0.208
Diseases of Immune System	R-HSA-5260271	6.193658e-01	0.208
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.193658e-01	0.208
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.193658e-01	0.208
Interleukin-2 family signaling	R-HSA-451927	6.193658e-01	0.208
Semaphorin interactions	R-HSA-373755	6.261440e-01	0.203
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.300334e-01	0.201
Reverse Transcription of HIV RNA	R-HSA-162589	6.327713e-01	0.199
Minus-strand DNA synthesis	R-HSA-164516	6.327713e-01	0.199
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.327713e-01	0.199
MET receptor recycling	R-HSA-8875656	6.327713e-01	0.199
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.327713e-01	0.199
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.327713e-01	0.199
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.327713e-01	0.199
Co-stimulation by ICOS	R-HSA-9927354	6.327713e-01	0.199
FGFR1b ligand binding and activation	R-HSA-190370	6.327713e-01	0.199
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.327713e-01	0.199
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.327713e-01	0.199
Nucleotide salvage defects	R-HSA-9734207	6.327713e-01	0.199
SLC-mediated bile acid transport	R-HSA-9958517	6.327713e-01	0.199
Sodium/Proton exchangers	R-HSA-425986	6.327713e-01	0.199
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.356349e-01	0.197
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.356349e-01	0.197
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.356349e-01	0.197
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.363046e-01	0.196
Orc1 removal from chromatin	R-HSA-68949	6.370129e-01	0.196
IGF1R signaling cascade	R-HSA-2428924	6.393755e-01	0.194
Platelet degranulation	R-HSA-114608	6.403163e-01	0.194
Regulation of signaling by CBL	R-HSA-912631	6.419595e-01	0.192
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.419595e-01	0.192
Rap1 signalling	R-HSA-392517	6.419595e-01	0.192
Maturation of nucleoprotein	R-HSA-9694631	6.419595e-01	0.192
Rab regulation of trafficking	R-HSA-9007101	6.458111e-01	0.190
Mitochondrial biogenesis	R-HSA-1592230	6.458111e-01	0.190
PIP3 activates AKT signaling	R-HSA-1257604	6.499260e-01	0.187
Meiotic synapsis	R-HSA-1221632	6.511908e-01	0.186
Signaling by FGFR1 in disease	R-HSA-5655302	6.514461e-01	0.186
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.520510e-01	0.186
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.520510e-01	0.186
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.523239e-01	0.186
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.542292e-01	0.184
Evasion by RSV of host interferon responses	R-HSA-9833109	6.544404e-01	0.184
Gastrulation	R-HSA-9758941	6.570377e-01	0.182
Intracellular signaling by second messengers	R-HSA-9006925	6.589561e-01	0.181
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.620151e-01	0.179
Signal transduction by L1	R-HSA-445144	6.637994e-01	0.178
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	6.637994e-01	0.178
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.647486e-01	0.177
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.647486e-01	0.177
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.647486e-01	0.177
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.647486e-01	0.177
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.647486e-01	0.177
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.647486e-01	0.177
p75NTR regulates axonogenesis	R-HSA-193697	6.647486e-01	0.177
mRNA Editing	R-HSA-75072	6.647486e-01	0.177
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.647486e-01	0.177
ARMS-mediated activation	R-HSA-170984	6.647486e-01	0.177
Regulation of signaling by NODAL	R-HSA-1433617	6.647486e-01	0.177
Respiratory syncytial virus genome replication	R-HSA-9834752	6.647486e-01	0.177
Regulated proteolysis of p75NTR	R-HSA-193692	6.647486e-01	0.177
Cellular response to mitochondrial stress	R-HSA-9840373	6.647486e-01	0.177
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.647486e-01	0.177
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.649090e-01	0.177
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.649090e-01	0.177
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.667925e-01	0.176
G0 and Early G1	R-HSA-1538133	6.719175e-01	0.173
Signaling by WNT in cancer	R-HSA-4791275	6.719175e-01	0.173
Signaling by FGFR4	R-HSA-5654743	6.816694e-01	0.166
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.845526e-01	0.165
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.845526e-01	0.165
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.845526e-01	0.165
Signalling to RAS	R-HSA-167044	6.845526e-01	0.165
ERK/MAPK targets	R-HSA-198753	6.845526e-01	0.165
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.845526e-01	0.165
Signaling by FGFR2	R-HSA-5654738	6.886907e-01	0.162
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.887358e-01	0.162
Nuclear RNA decay	R-HSA-9930044	6.887358e-01	0.162
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.887358e-01	0.162
Regulation of MECP2 expression and activity	R-HSA-9022692	6.887358e-01	0.162
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.887358e-01	0.162
Signaling by FGFR1	R-HSA-5654736	6.915629e-01	0.160
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.924270e-01	0.160
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.924270e-01	0.160
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.939431e-01	0.159
DNA replication initiation	R-HSA-68952	6.939431e-01	0.159
Folding of actin by CCT/TriC	R-HSA-390450	6.939431e-01	0.159
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.939431e-01	0.159
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.939431e-01	0.159
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.939431e-01	0.159
MET activates RAP1 and RAC1	R-HSA-8875555	6.939431e-01	0.159
EGFR Transactivation by Gastrin	R-HSA-2179392	6.939431e-01	0.159
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.939431e-01	0.159
Pexophagy	R-HSA-9664873	6.939431e-01	0.159
Receptor Mediated Mitophagy	R-HSA-8934903	6.939431e-01	0.159
Sperm Motility And Taxes	R-HSA-1300642	6.939431e-01	0.159
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.939431e-01	0.159
Formation of apoptosome	R-HSA-111458	6.939431e-01	0.159
Regulation of the apoptosome activity	R-HSA-9627069	6.939431e-01	0.159
DNA Repair	R-HSA-73894	6.959084e-01	0.157
Cyclin D associated events in G1	R-HSA-69231	6.960743e-01	0.157
G1 Phase	R-HSA-69236	6.960743e-01	0.157
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.960743e-01	0.157
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.001891e-01	0.155
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.001891e-01	0.155
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.026503e-01	0.153
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.042427e-01	0.152
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.042427e-01	0.152
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.042427e-01	0.152
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.042427e-01	0.152
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.042427e-01	0.152
Assembly Of The HIV Virion	R-HSA-175474	7.042427e-01	0.152
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.042427e-01	0.152
Regulation of CDH1 Function	R-HSA-9764561	7.042864e-01	0.152
IRS-mediated signalling	R-HSA-112399	7.042864e-01	0.152
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.048981e-01	0.152
Miscellaneous transport and binding events	R-HSA-5223345	7.048981e-01	0.152
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.092987e-01	0.149
Nucleosome assembly	R-HSA-774815	7.100062e-01	0.149
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.100062e-01	0.149
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.100062e-01	0.149
Signaling by FGFR3	R-HSA-5654741	7.100062e-01	0.149
DAG and IP3 signaling	R-HSA-1489509	7.100062e-01	0.149
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.126418e-01	0.147
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.204101e-01	0.142
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.204101e-01	0.142
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.204101e-01	0.142
Mitophagy	R-HSA-5205647	7.204101e-01	0.142
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.204101e-01	0.142
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.205968e-01	0.142
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.205968e-01	0.142
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.205968e-01	0.142
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.205968e-01	0.142
Activated NTRK3 signals through RAS	R-HSA-9034864	7.205968e-01	0.142
vRNA Synthesis	R-HSA-192814	7.205968e-01	0.142
Signaling by APC mutants	R-HSA-4839744	7.205968e-01	0.142
RHOBTB3 ATPase cycle	R-HSA-9706019	7.205968e-01	0.142
Bicarbonate transporters	R-HSA-425381	7.205968e-01	0.142
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.205968e-01	0.142
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.205968e-01	0.142
Suppression of apoptosis	R-HSA-9635465	7.205968e-01	0.142
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.205968e-01	0.142
Dissolution of Fibrin Clot	R-HSA-75205	7.205968e-01	0.142
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.228974e-01	0.141
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.228974e-01	0.141
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.228974e-01	0.141
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.228974e-01	0.141
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.228974e-01	0.141
Signaling by KIT in disease	R-HSA-9669938	7.228974e-01	0.141
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.228974e-01	0.141
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.234659e-01	0.141
G1/S Transition	R-HSA-69206	7.269096e-01	0.139
Developmental Lineages of the Mammary Gland	R-HSA-9924644	7.346480e-01	0.134
Oncogene Induced Senescence	R-HSA-2559585	7.352798e-01	0.134
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.352798e-01	0.134
Developmental Cell Lineages	R-HSA-9734767	7.356915e-01	0.133
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.364557e-01	0.133
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.364557e-01	0.133
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.365428e-01	0.133
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.405477e-01	0.130
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.405477e-01	0.130
MAPK6/MAPK4 signaling	R-HSA-5687128	7.410160e-01	0.130
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.429090e-01	0.129
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.449308e-01	0.128
Signaling by GSK3beta mutants	R-HSA-5339716	7.449308e-01	0.128
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.449308e-01	0.128
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	7.449308e-01	0.128
Activated NTRK2 signals through RAS	R-HSA-9026519	7.449308e-01	0.128
Plasmalogen biosynthesis	R-HSA-75896	7.449308e-01	0.128
Signaling by AMER1 mutants	R-HSA-4839748	7.449308e-01	0.128
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.449308e-01	0.128
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.449308e-01	0.128
Anchoring fibril formation	R-HSA-2214320	7.449308e-01	0.128
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.449308e-01	0.128
Integration of provirus	R-HSA-162592	7.449308e-01	0.128
MAPK family signaling cascades	R-HSA-5683057	7.484697e-01	0.126
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.495170e-01	0.125
RNA Polymerase III Transcription	R-HSA-74158	7.495170e-01	0.125
Calmodulin induced events	R-HSA-111933	7.495170e-01	0.125
CaM pathway	R-HSA-111997	7.495170e-01	0.125
G1/S-Specific Transcription	R-HSA-69205	7.495170e-01	0.125
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.506999e-01	0.125
Signaling by FGFR in disease	R-HSA-1226099	7.554306e-01	0.122
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.572271e-01	0.121
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.572271e-01	0.121
Complex III assembly	R-HSA-9865881	7.572271e-01	0.121
Potential therapeutics for SARS	R-HSA-9679191	7.574184e-01	0.121
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.601822e-01	0.119
Degradation of CDH1	R-HSA-9766229	7.610416e-01	0.119
Stimuli-sensing channels	R-HSA-2672351	7.622486e-01	0.118
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.623521e-01	0.118
Regulation of T cell activation by CD28 family	R-HSA-388841	7.626165e-01	0.118
TRAF6 mediated IRF7 activation	R-HSA-933541	7.631334e-01	0.117
Degradation of DVL	R-HSA-4641258	7.631334e-01	0.117
Protein ubiquitination	R-HSA-8852135	7.653651e-01	0.116
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.671468e-01	0.115
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.671468e-01	0.115
GRB2 events in EGFR signaling	R-HSA-179812	7.671468e-01	0.115
Scavenging by Class F Receptors	R-HSA-3000484	7.671468e-01	0.115
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.671468e-01	0.115
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.671468e-01	0.115
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.671468e-01	0.115
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.671468e-01	0.115
MET activates RAS signaling	R-HSA-8851805	7.671468e-01	0.115
p75NTR recruits signalling complexes	R-HSA-209543	7.671468e-01	0.115
SHC-related events triggered by IGF1R	R-HSA-2428933	7.671468e-01	0.115
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	7.671468e-01	0.115
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.671468e-01	0.115
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.671468e-01	0.115
IRAK1 recruits IKK complex	R-HSA-937039	7.671468e-01	0.115
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.671468e-01	0.115
OAS antiviral response	R-HSA-8983711	7.671468e-01	0.115
Interleukin-15 signaling	R-HSA-8983432	7.671468e-01	0.115
Signaling by FGFR2 in disease	R-HSA-5655253	7.726486e-01	0.112
PI3K Cascade	R-HSA-109704	7.726486e-01	0.112
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.728650e-01	0.112
Signaling by PTK6	R-HSA-8848021	7.728650e-01	0.112
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.728650e-01	0.112
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.729706e-01	0.112
Formation of the nephric duct	R-HSA-9830364	7.729706e-01	0.112
Sema4D in semaphorin signaling	R-HSA-400685	7.729706e-01	0.112
Signaling by FGFR	R-HSA-190236	7.737002e-01	0.111
Signaling by NOTCH1	R-HSA-1980143	7.749973e-01	0.111
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.761425e-01	0.110
Neutrophil degranulation	R-HSA-6798695	7.770939e-01	0.110
Disorders of transmembrane transporters	R-HSA-5619115	7.781742e-01	0.109
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.783741e-01	0.109
MyD88-independent TLR4 cascade	R-HSA-166166	7.783741e-01	0.109
Muscle contraction	R-HSA-397014	7.825701e-01	0.106
Insulin receptor signalling cascade	R-HSA-74751	7.830185e-01	0.106
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.830185e-01	0.106
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.831690e-01	0.106
Platelet Adhesion to exposed collagen	R-HSA-75892	7.874290e-01	0.104
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.874290e-01	0.104
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.874290e-01	0.104
FGFR1c ligand binding and activation	R-HSA-190373	7.874290e-01	0.104
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.874290e-01	0.104
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.874290e-01	0.104
Diseases of nucleotide metabolism	R-HSA-9735804	7.874290e-01	0.104
CD28 dependent Vav1 pathway	R-HSA-389359	7.874290e-01	0.104
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.874290e-01	0.104
Interleukin-6 signaling	R-HSA-1059683	7.874290e-01	0.104
Signaling by EGFR in Cancer	R-HSA-1643713	7.878148e-01	0.104
MET activates PTK2 signaling	R-HSA-8874081	7.878148e-01	0.104
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.878148e-01	0.104
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	7.878148e-01	0.104
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.885585e-01	0.103
Cellular response to hypoxia	R-HSA-1234174	7.928171e-01	0.101
PCP/CE pathway	R-HSA-4086400	7.933656e-01	0.101
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.945256e-01	0.100
Uptake and actions of bacterial toxins	R-HSA-5339562	7.945256e-01	0.100
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.945256e-01	0.100
Interleukin-1 signaling	R-HSA-9020702	7.978946e-01	0.098
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.002407e-01	0.097
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.003970e-01	0.097
Cristae formation	R-HSA-8949613	8.017969e-01	0.096
Signaling by FGFR3 in disease	R-HSA-5655332	8.017969e-01	0.096
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.017969e-01	0.096
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.017969e-01	0.096
Insulin processing	R-HSA-264876	8.017969e-01	0.096
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.021079e-01	0.096
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.033696e-01	0.095
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.048120e-01	0.094
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.048120e-01	0.094
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.059457e-01	0.094
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.059457e-01	0.094
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.059457e-01	0.094
NRIF signals cell death from the nucleus	R-HSA-205043	8.059457e-01	0.094
Physiological factors	R-HSA-5578768	8.059457e-01	0.094
Prolactin receptor signaling	R-HSA-1170546	8.059457e-01	0.094
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.059457e-01	0.094
Malate-aspartate shuttle	R-HSA-9856872	8.059457e-01	0.094
HDL assembly	R-HSA-8963896	8.059457e-01	0.094
RAF/MAP kinase cascade	R-HSA-5673001	8.093612e-01	0.092
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.113708e-01	0.091
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.116744e-01	0.091
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.146758e-01	0.089
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.149543e-01	0.089
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.149543e-01	0.089
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.201377e-01	0.086
Signaling by Nuclear Receptors	R-HSA-9006931	8.203277e-01	0.086
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.224077e-01	0.085
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.228505e-01	0.085
Beta-catenin phosphorylation cascade	R-HSA-196299	8.228505e-01	0.085
RNA Polymerase III Chain Elongation	R-HSA-73780	8.228505e-01	0.085
Telomere C-strand synthesis initiation	R-HSA-174430	8.228505e-01	0.085
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.228505e-01	0.085
SHC1 events in EGFR signaling	R-HSA-180336	8.228505e-01	0.085
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.228505e-01	0.085
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.228505e-01	0.085
p38MAPK events	R-HSA-171007	8.228505e-01	0.085
DNA Damage Reversal	R-HSA-73942	8.228505e-01	0.085
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.228505e-01	0.085
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.241268e-01	0.084
rRNA processing	R-HSA-72312	8.242367e-01	0.084
Signaling by Erythropoietin	R-HSA-9006335	8.273246e-01	0.082
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.273246e-01	0.082
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	8.273246e-01	0.082
Downstream signaling of activated FGFR3	R-HSA-5654708	8.273246e-01	0.082
Ca-dependent events	R-HSA-111996	8.326144e-01	0.080
Cleavage of the damaged pyrimidine	R-HSA-110329	8.326144e-01	0.080
Depyrimidination	R-HSA-73928	8.326144e-01	0.080
Signaling by Hedgehog	R-HSA-5358351	8.328371e-01	0.079
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.331753e-01	0.079
Collagen formation	R-HSA-1474290	8.334627e-01	0.079
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.366846e-01	0.077
RNA Polymerase II Transcription	R-HSA-73857	8.376016e-01	0.077
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.382835e-01	0.077
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.382835e-01	0.077
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.382835e-01	0.077
Regulation of NF-kappa B signaling	R-HSA-9758274	8.382835e-01	0.077
Class I peroxisomal membrane protein import	R-HSA-9603798	8.382835e-01	0.077
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.382835e-01	0.077
Differentiation of T cells	R-HSA-9945266	8.382835e-01	0.077
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.382835e-01	0.077
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.382835e-01	0.077
Attachment and Entry	R-HSA-9678110	8.382835e-01	0.077
DAP12 signaling	R-HSA-2424491	8.389450e-01	0.076
Downstream signaling of activated FGFR4	R-HSA-5654716	8.389450e-01	0.076
Downregulation of ERBB2 signaling	R-HSA-8863795	8.389450e-01	0.076
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.389450e-01	0.076
Interleukin-37 signaling	R-HSA-9008059	8.389450e-01	0.076
MAPK1/MAPK3 signaling	R-HSA-5684996	8.396117e-01	0.076
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.408860e-01	0.075
Response of Mtb to phagocytosis	R-HSA-9637690	8.423123e-01	0.075
Platelet activation, signaling and aggregation	R-HSA-76002	8.486402e-01	0.071
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.498523e-01	0.071
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.501077e-01	0.071
EPHB-mediated forward signaling	R-HSA-3928662	8.515196e-01	0.070
Amine ligand-binding receptors	R-HSA-375280	8.515196e-01	0.070
G beta:gamma signalling through CDC42	R-HSA-8964616	8.523728e-01	0.069
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.523728e-01	0.069
Processing of Intronless Pre-mRNAs	R-HSA-77595	8.523728e-01	0.069
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.523728e-01	0.069
Fibronectin matrix formation	R-HSA-1566977	8.523728e-01	0.069
Synthesis of PG	R-HSA-1483148	8.523728e-01	0.069
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.523728e-01	0.069
tRNA modification in the mitochondrion	R-HSA-6787450	8.523728e-01	0.069
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	8.523728e-01	0.069
Asymmetric localization of PCP proteins	R-HSA-4608870	8.602544e-01	0.065
PPARA activates gene expression	R-HSA-1989781	8.614743e-01	0.065
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.652354e-01	0.063
Glycogen storage diseases	R-HSA-3229121	8.652354e-01	0.063
Regulation of FZD by ubiquitination	R-HSA-4641263	8.652354e-01	0.063
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.652354e-01	0.063
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.652354e-01	0.063
Choline catabolism	R-HSA-6798163	8.652354e-01	0.063
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	8.655613e-01	0.063
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	8.655613e-01	0.063
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	8.655613e-01	0.063
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	8.655613e-01	0.063
Signaling by NOTCH1 in Cancer	R-HSA-2644603	8.655613e-01	0.063
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.685349e-01	0.061
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.685349e-01	0.061
Diseases of DNA repair	R-HSA-9675135	8.685349e-01	0.061
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.696708e-01	0.061
G-protein beta:gamma signalling	R-HSA-397795	8.696708e-01	0.061
FGFR1 mutant receptor activation	R-HSA-1839124	8.696708e-01	0.061
Cardiogenesis	R-HSA-9733709	8.696708e-01	0.061
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.709517e-01	0.060
PLC beta mediated events	R-HSA-112043	8.727620e-01	0.059
Collagen degradation	R-HSA-1442490	8.727620e-01	0.059
Formation of paraxial mesoderm	R-HSA-9793380	8.727620e-01	0.059
G beta:gamma signalling through PLC beta	R-HSA-418217	8.769780e-01	0.057
RNA Polymerase III Transcription Termination	R-HSA-73980	8.769780e-01	0.057
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.769780e-01	0.057
PKA activation	R-HSA-163615	8.769780e-01	0.057
PKA activation in glucagon signalling	R-HSA-164378	8.769780e-01	0.057
Presynaptic function of Kainate receptors	R-HSA-500657	8.769780e-01	0.057
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.769780e-01	0.057
FGFR1 ligand binding and activation	R-HSA-190242	8.769780e-01	0.057
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.769780e-01	0.057
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.769780e-01	0.057
GAB1 signalosome	R-HSA-180292	8.769780e-01	0.057
Apoptotic factor-mediated response	R-HSA-111471	8.769780e-01	0.057
Resolution of D-Loop Structures	R-HSA-5693537	8.786512e-01	0.056
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.786512e-01	0.056
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.786512e-01	0.056
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.796273e-01	0.056
NCAM signaling for neurite out-growth	R-HSA-375165	8.796273e-01	0.056
Co-stimulation by CD28	R-HSA-389356	8.838052e-01	0.054
Translation	R-HSA-72766	8.840215e-01	0.054
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.861688e-01	0.052
Signaling by NOTCH2	R-HSA-1980145	8.870569e-01	0.052
NOD1/2 Signaling Pathway	R-HSA-168638	8.870569e-01	0.052
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.870569e-01	0.052
Impaired BRCA2 binding to PALB2	R-HSA-9709603	8.876981e-01	0.052
PI-3K cascade:FGFR3	R-HSA-5654710	8.876981e-01	0.052
Crosslinking of collagen fibrils	R-HSA-2243919	8.876981e-01	0.052
Pyrimidine biosynthesis	R-HSA-500753	8.876981e-01	0.052
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.876981e-01	0.052
E2F mediated regulation of DNA replication	R-HSA-113510	8.876981e-01	0.052
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.876981e-01	0.052
Diseases of hemostasis	R-HSA-9671793	8.876981e-01	0.052
Specification of the neural plate border	R-HSA-9834899	8.876981e-01	0.052
Integrin cell surface interactions	R-HSA-216083	8.908094e-01	0.050
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.908307e-01	0.050
Ion transport by P-type ATPases	R-HSA-936837	8.923978e-01	0.049
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.926750e-01	0.049
Downstream signaling of activated FGFR2	R-HSA-5654696	8.949198e-01	0.048
Downstream signaling of activated FGFR1	R-HSA-5654687	8.949198e-01	0.048
Regulation of Apoptosis	R-HSA-169911	8.949198e-01	0.048
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.953128e-01	0.048
Regulation of RAS by GAPs	R-HSA-5658442	8.974730e-01	0.047
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.974846e-01	0.047
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.974846e-01	0.047
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.974846e-01	0.047
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.974846e-01	0.047
PI-3K cascade:FGFR4	R-HSA-5654720	8.974846e-01	0.047
Glycogen synthesis	R-HSA-3322077	8.974846e-01	0.047
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.974846e-01	0.047
Wax and plasmalogen biosynthesis	R-HSA-8848584	8.974846e-01	0.047
Signaling by NODAL	R-HSA-1181150	8.974846e-01	0.047
Creatine metabolism	R-HSA-71288	8.974846e-01	0.047
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.974846e-01	0.047
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.016445e-01	0.045
RSV-host interactions	R-HSA-9833110	9.022505e-01	0.045
GPVI-mediated activation cascade	R-HSA-114604	9.022708e-01	0.045
Glycosphingolipid transport	R-HSA-9845576	9.022708e-01	0.045
Regulation of TP53 Degradation	R-HSA-6804757	9.022708e-01	0.045
FGFR2 mutant receptor activation	R-HSA-1839126	9.022708e-01	0.045
Activation of NF-kappaB in B cells	R-HSA-1169091	9.037492e-01	0.044
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.037492e-01	0.044
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.064188e-01	0.043
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.064188e-01	0.043
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.064188e-01	0.043
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.064188e-01	0.043
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.064188e-01	0.043
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.064188e-01	0.043
Amyloid fiber formation	R-HSA-977225	9.067026e-01	0.043
Toll-like Receptor Cascades	R-HSA-168898	9.074478e-01	0.042
Degradation of AXIN	R-HSA-4641257	9.091391e-01	0.041
G-protein mediated events	R-HSA-112040	9.093239e-01	0.041
Kidney development	R-HSA-9830369	9.093239e-01	0.041
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.096760e-01	0.041
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.096760e-01	0.041
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.145748e-01	0.039
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.145748e-01	0.039
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.145748e-01	0.039
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.145748e-01	0.039
Molybdenum cofactor biosynthesis	R-HSA-947581	9.145748e-01	0.039
Serine metabolism	R-HSA-977347	9.145748e-01	0.039
Attachment and Entry	R-HSA-9694614	9.145748e-01	0.039
Amino acids regulate mTORC1	R-HSA-9639288	9.152696e-01	0.038
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.155532e-01	0.038
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.155532e-01	0.038
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.205458e-01	0.036
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.215400e-01	0.035
Regulation of TP53 Expression and Degradation	R-HSA-6806003	9.215400e-01	0.035
PI-3K cascade:FGFR1	R-HSA-5654689	9.220205e-01	0.035
Neurotoxicity of clostridium toxins	R-HSA-168799	9.220205e-01	0.035
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.220205e-01	0.035
Ethanol oxidation	R-HSA-71384	9.220205e-01	0.035
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.220205e-01	0.035
RAF-independent MAPK1/3 activation	R-HSA-112409	9.220205e-01	0.035
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.231433e-01	0.035
TCR signaling	R-HSA-202403	9.264251e-01	0.033
Nuclear signaling by ERBB4	R-HSA-1251985	9.271252e-01	0.033
Generation of second messenger molecules	R-HSA-202433	9.271252e-01	0.033
Interferon gamma signaling	R-HSA-877300	9.275044e-01	0.033
Regulation of mitotic cell cycle	R-HSA-453276	9.281940e-01	0.032
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.281940e-01	0.032
Regulation of PTEN mRNA translation	R-HSA-8943723	9.288176e-01	0.032
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.288176e-01	0.032
Free fatty acids regulate insulin secretion	R-HSA-400451	9.288176e-01	0.032
Organic anion transport by SLCO transporters	R-HSA-879518	9.288176e-01	0.032
Carnitine shuttle	R-HSA-200425	9.288176e-01	0.032
Post-translational protein phosphorylation	R-HSA-8957275	9.306091e-01	0.031
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.323215e-01	0.030
Hh mutants are degraded by ERAD	R-HSA-5362768	9.323333e-01	0.030
Maturation of spike protein	R-HSA-9694548	9.323333e-01	0.030
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.325238e-01	0.030
FOXO-mediated transcription	R-HSA-9614085	9.340961e-01	0.030
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.348017e-01	0.029
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.350226e-01	0.029
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.350226e-01	0.029
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	9.350226e-01	0.029
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.350226e-01	0.029
Plasma lipoprotein assembly	R-HSA-8963898	9.350226e-01	0.029
Interleukin-6 family signaling	R-HSA-6783589	9.350226e-01	0.029
Beta-catenin independent WNT signaling	R-HSA-3858494	9.366336e-01	0.028
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.371876e-01	0.028
Degradation of CRY and PER proteins	R-HSA-9932298	9.371876e-01	0.028
Intra-Golgi traffic	R-HSA-6811438	9.371876e-01	0.028
Translation of Structural Proteins	R-HSA-9683701	9.371876e-01	0.028
Signaling by NOTCH	R-HSA-157118	9.376293e-01	0.028
Ion channel transport	R-HSA-983712	9.389530e-01	0.027
Signaling by NOTCH4	R-HSA-9013694	9.399382e-01	0.027
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.406870e-01	0.027
PI-3K cascade:FGFR2	R-HSA-5654695	9.406870e-01	0.027
Long-term potentiation	R-HSA-9620244	9.406870e-01	0.027
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.406870e-01	0.027
Tight junction interactions	R-HSA-420029	9.406870e-01	0.027
Hyaluronan degradation	R-HSA-2160916	9.406870e-01	0.027
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.406870e-01	0.027
Fertilization	R-HSA-1187000	9.406870e-01	0.027
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.406870e-01	0.027
Laminin interactions	R-HSA-3000157	9.406870e-01	0.027
Cytosolic tRNA aminoacylation	R-HSA-379716	9.417103e-01	0.026
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.417103e-01	0.026
Peroxisomal protein import	R-HSA-9033241	9.426867e-01	0.026
Amino acid transport across the plasma membrane	R-HSA-352230	9.426867e-01	0.026
Phospholipid metabolism	R-HSA-1483257	9.443200e-01	0.025
Interleukin-1 family signaling	R-HSA-446652	9.451009e-01	0.025
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.458580e-01	0.024
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.458580e-01	0.024
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.458580e-01	0.024
Sphingolipid catabolism	R-HSA-9845614	9.458580e-01	0.024
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.458580e-01	0.024
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.459221e-01	0.024
Downstream TCR signaling	R-HSA-202424	9.459846e-01	0.024
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.463638e-01	0.024
Protein localization	R-HSA-9609507	9.474657e-01	0.023
Transcriptional Regulation by MECP2	R-HSA-8986944	9.489464e-01	0.023
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.495208e-01	0.022
DAP12 interactions	R-HSA-2172127	9.498429e-01	0.022
Translation of Structural Proteins	R-HSA-9694635	9.499067e-01	0.022
Packaging Of Telomere Ends	R-HSA-171306	9.505784e-01	0.022
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.505784e-01	0.022
Triglyceride biosynthesis	R-HSA-75109	9.505784e-01	0.022
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.505784e-01	0.022
Maturation of hRSV A proteins	R-HSA-9828806	9.505784e-01	0.022
Generic Transcription Pathway	R-HSA-212436	9.522606e-01	0.021
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.534915e-01	0.021
Fanconi Anemia Pathway	R-HSA-6783310	9.534915e-01	0.021
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.534915e-01	0.021
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.534915e-01	0.021
Signaling by Insulin receptor	R-HSA-74752	9.544319e-01	0.020
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.544319e-01	0.020
Telomere Extension By Telomerase	R-HSA-171319	9.548875e-01	0.020
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.548875e-01	0.020
Pyroptosis	R-HSA-5620971	9.548875e-01	0.020
G1/S DNA Damage Checkpoints	R-HSA-69615	9.561190e-01	0.019
Transcriptional regulation by RUNX2	R-HSA-8878166	9.574692e-01	0.019
Signaling by ERBB2 KD Mutants	R-HSA-9664565	9.588212e-01	0.018
DARPP-32 events	R-HSA-180024	9.588212e-01	0.018
Synthesis of PC	R-HSA-1483191	9.600414e-01	0.018
Activation of BH3-only proteins	R-HSA-114452	9.624120e-01	0.017
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.624120e-01	0.017
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.624120e-01	0.017
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.641928e-01	0.016
Hemostasis	R-HSA-109582	9.652547e-01	0.015
Cytoprotection by HMOX1	R-HSA-9707564	9.654345e-01	0.015
Trafficking of AMPA receptors	R-HSA-399719	9.656899e-01	0.015
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.656899e-01	0.015
Cargo concentration in the ER	R-HSA-5694530	9.656899e-01	0.015
Molecules associated with elastic fibres	R-HSA-2129379	9.656899e-01	0.015
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.657011e-01	0.015
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.657011e-01	0.015
SLC-mediated transport of amino acids	R-HSA-9958863	9.665576e-01	0.015
Formation of the cornified envelope	R-HSA-6809371	9.671999e-01	0.014
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.686822e-01	0.014
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.686822e-01	0.014
Hedgehog ligand biogenesis	R-HSA-5358346	9.705854e-01	0.013
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.714136e-01	0.013
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	9.714136e-01	0.013
Regulation of necroptotic cell death	R-HSA-5675482	9.714136e-01	0.013
Cyclin E associated events during G1/S transition	R-HSA-69202	9.727979e-01	0.012
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.737310e-01	0.012
Acyl chain remodelling of PC	R-HSA-1482788	9.739070e-01	0.011
Vpu mediated degradation of CD4	R-HSA-180534	9.739070e-01	0.011
Glucagon signaling in metabolic regulation	R-HSA-163359	9.739070e-01	0.011
ECM proteoglycans	R-HSA-3000178	9.746203e-01	0.011
Hedgehog 'on' state	R-HSA-5632684	9.746203e-01	0.011
Nucleotide biosynthesis	R-HSA-8956320	9.747953e-01	0.011
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.751729e-01	0.011
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.761830e-01	0.010
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.761830e-01	0.010
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.761830e-01	0.010
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.761830e-01	0.010
Hyaluronan metabolism	R-HSA-2142845	9.761830e-01	0.010
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.761830e-01	0.010
NPAS4 regulates expression of target genes	R-HSA-9768919	9.761830e-01	0.010
ER-Phagosome pathway	R-HSA-1236974	9.778543e-01	0.010
Ca2+ pathway	R-HSA-4086398	9.779229e-01	0.010
C-type lectin receptors (CLRs)	R-HSA-5621481	9.782013e-01	0.010
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.782606e-01	0.010
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.782606e-01	0.010
Acyl chain remodelling of PE	R-HSA-1482839	9.782606e-01	0.010
Transferrin endocytosis and recycling	R-HSA-917977	9.782606e-01	0.010
G alpha (z) signalling events	R-HSA-418597	9.784198e-01	0.009
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.786659e-01	0.009
Neurotransmitter release cycle	R-HSA-112310	9.792397e-01	0.009
Signaling by ERBB4	R-HSA-1236394	9.794166e-01	0.009
Cardiac conduction	R-HSA-5576891	9.797629e-01	0.009
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.800373e-01	0.009
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.801571e-01	0.009
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.801571e-01	0.009
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.808135e-01	0.008
Degradation of the extracellular matrix	R-HSA-1474228	9.808422e-01	0.008
Voltage gated Potassium channels	R-HSA-1296072	9.818883e-01	0.008
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.818883e-01	0.008
Cleavage of the damaged purine	R-HSA-110331	9.818883e-01	0.008
NCAM1 interactions	R-HSA-419037	9.818883e-01	0.008
SLC-mediated transport of organic cations	R-HSA-549127	9.818883e-01	0.008
Metabolism of folate and pterines	R-HSA-196757	9.818883e-01	0.008
Platelet homeostasis	R-HSA-418346	9.823422e-01	0.008
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.829214e-01	0.007
tRNA processing in the mitochondrion	R-HSA-6785470	9.834685e-01	0.007
Depurination	R-HSA-73927	9.834685e-01	0.007
Elastic fibre formation	R-HSA-1566948	9.834685e-01	0.007
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.834685e-01	0.007
Purine salvage	R-HSA-74217	9.834685e-01	0.007
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.834685e-01	0.007
Antigen processing-Cross presentation	R-HSA-1236975	9.843842e-01	0.007
SLC-mediated transport of organic anions	R-HSA-9955298	9.844815e-01	0.007
Cholesterol biosynthesis	R-HSA-191273	9.844815e-01	0.007
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.849109e-01	0.007
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.849109e-01	0.007
Stabilization of p53	R-HSA-69541	9.849109e-01	0.007
Pentose phosphate pathway	R-HSA-71336	9.849109e-01	0.007
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.850226e-01	0.007
tRNA Aminoacylation	R-HSA-379724	9.854087e-01	0.006
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.855472e-01	0.006
Glycogen metabolism	R-HSA-8982491	9.862276e-01	0.006
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.862276e-01	0.006
rRNA processing in the mitochondrion	R-HSA-8868766	9.862276e-01	0.006
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.862276e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.862276e-01	0.006
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.862276e-01	0.006
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.865142e-01	0.006
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.874294e-01	0.005
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.874294e-01	0.005
Mitochondrial protein import	R-HSA-1268020	9.875379e-01	0.005
Cellular response to chemical stress	R-HSA-9711123	9.877956e-01	0.005
Parasite infection	R-HSA-9664407	9.884134e-01	0.005
Leishmania phagocytosis	R-HSA-9664417	9.884134e-01	0.005
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.884134e-01	0.005
Complex I biogenesis	R-HSA-6799198	9.884857e-01	0.005
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.885264e-01	0.005
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.885264e-01	0.005
Scavenging by Class A Receptors	R-HSA-3000480	9.885264e-01	0.005
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.891489e-01	0.005
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.895278e-01	0.005
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.904262e-01	0.004
Adaptive Immune System	R-HSA-1280218	9.904350e-01	0.004
Extra-nuclear estrogen signaling	R-HSA-9009391	9.912162e-01	0.004
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.912655e-01	0.004
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.912761e-01	0.004
Proteasome assembly	R-HSA-9907900	9.912761e-01	0.004
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.912761e-01	0.004
Nicotinate metabolism	R-HSA-196807	9.916216e-01	0.004
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.920376e-01	0.003
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.920376e-01	0.003
Somitogenesis	R-HSA-9824272	9.920376e-01	0.003
Regulated Necrosis	R-HSA-5218859	9.922646e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.924488e-01	0.003
Regulation of pyruvate metabolism	R-HSA-9861718	9.927327e-01	0.003
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.927327e-01	0.003
Opioid Signalling	R-HSA-111885	9.928328e-01	0.003
Transmission across Chemical Synapses	R-HSA-112315	9.930062e-01	0.003
Infectious disease	R-HSA-5663205	9.930746e-01	0.003
COPII-mediated vesicle transport	R-HSA-204005	9.934089e-01	0.003
GPER1 signaling	R-HSA-9634597	9.939462e-01	0.003
Metal ion SLC transporters	R-HSA-425410	9.939462e-01	0.003
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.943870e-01	0.002
Chemokine receptors bind chemokines	R-HSA-380108	9.944747e-01	0.002
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.946870e-01	0.002
Azathioprine ADME	R-HSA-9748787	9.949572e-01	0.002
Neuronal System	R-HSA-112316	9.950722e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.952223e-01	0.002
Complex IV assembly	R-HSA-9864848	9.953975e-01	0.002
The phototransduction cascade	R-HSA-2514856	9.953975e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.954875e-01	0.002
Glycerophospholipid biosynthesis	R-HSA-1483206	9.957806e-01	0.002
Ub-specific processing proteases	R-HSA-5689880	9.961307e-01	0.002
FCERI mediated MAPK activation	R-HSA-2871796	9.961441e-01	0.002
Regulation of PTEN stability and activity	R-HSA-8948751	9.961663e-01	0.002
Asparagine N-linked glycosylation	R-HSA-446203	9.964826e-01	0.002
Neddylation	R-HSA-8951664	9.965155e-01	0.002
ABC transporter disorders	R-HSA-5619084	9.965435e-01	0.002
Interleukin-10 signaling	R-HSA-6783783	9.965435e-01	0.002
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.968598e-01	0.001
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.968743e-01	0.001
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.970856e-01	0.001
Regulation of insulin secretion	R-HSA-422356	9.971152e-01	0.001
Synthesis of PA	R-HSA-1483166	9.973402e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.973919e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.975178e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.976411e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.977846e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.979782e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.979782e-01	0.001
Aquaporin-mediated transport	R-HSA-445717	9.981548e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.981548e-01	0.001
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.982672e-01	0.001
Immune System	R-HSA-168256	9.983645e-01	0.001
Post-translational protein modification	R-HSA-597592	9.983991e-01	0.001
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.984010e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.985369e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.992118e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.992631e-01	0.000
Leishmania infection	R-HSA-9658195	9.992631e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.993727e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.993843e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.993848e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.994873e-01	0.000
Iron uptake and transport	R-HSA-917937	9.994873e-01	0.000
Integration of energy metabolism	R-HSA-163685	9.995186e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.996066e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.997529e-01	0.000
Keratinization	R-HSA-6805567	9.998437e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999028e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999172e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999251e-01	0.000
Potassium Channels	R-HSA-1296071	9.999431e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999568e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999696e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999856e-01	0.000
Disease	R-HSA-1643685	9.999858e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999869e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999924e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999952e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999952e-01	0.000
Innate Immune System	R-HSA-168249	9.999956e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999958e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999965e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999972e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999975e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999981e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999986e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999994e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999996e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999996e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999997e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999998e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999998e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000