VRK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

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Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O14920	S177	GPS6\|PSP	IKBKB IKKB	EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14920	S181	GPS6\|PSP	IKBKB IKKB	IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O75531	S4	GPS6\|SIGNOR\|EPSD\|PSP	BANF1 BAF BCRG1	_________________MttsQKHRDFVAEPMGEKPVGSLA
O75531	T2	GPS6\|SIGNOR\|EPSD\|PSP	BANF1 BAF BCRG1	___________________MttsQKHRDFVAEPMGEKPVGS
O75531	T3	GPS6\|SIGNOR\|EPSD\|PSP	BANF1 BAF BCRG1	__________________MttsQKHRDFVAEPMGEKPVGSL
P04406	S151	SIGNOR	GAPDH GAPD CDABP0047 OK/SW-cl.12	FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04637	T18	GPS6	TP53 P53	___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S86	Sugiyama	HSPB1 HSP27 HSP28	PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P10809	T117	Sugiyama	HSPD1 HSP60	LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P29401	T287	SIGNOR	TKT	AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P35579	Y9	Sugiyama	MYH9	____________MAQQAADKyLyVDKNFINNPLAQADWAAK
P38432	S184	EPSD\|PSP	COIL CLN80	RKNKATCGTVGDDNEEAKRKsPKKKEKCEYKKKAKNPKsPK
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778	Y30	Sugiyama	RPL21	GTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQK
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P53350	T210	PSP	PLK1 PLK	VKIGDFGLATKVEYDGERKKtLCGtPNyIAPEVLSKKGHSF
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62424	T93	Sugiyama	RPL7A SURF-3 SURF3	RLKVPPAINQFtQALDRQTAtQLLKLAHKYRPEtKQEKKQR
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q13469	S31	SIGNOR	NFATC2 NFAT1 NFATP	DGGDAPGHEPGGSPQDELDFsILFDYEYLNPNEEEPNAHKV
Q14444	T303	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q86Y07	S190	Sugiyama	VRK2	ANLLLGYKNPDQVYLADYGLsYRYCPNGNHKQYQENPRKGH
Q86Y07	S218	Sugiyama	VRK2	NHKQYQENPRKGHNGTIEFTsLDAHKGVALSRRSDVEILGY
Q86Y07	S339	Sugiyama	VRK2	PLGPLDFSTKGQSINVHtPNsQKVDSQKAATKQVNKAHNRL
Q86Y07	T397	Sugiyama	VRK2	KVQKEEKLIGLMNNEAAQEstRRRQKyQEsQEPLNEVNSFP
Q86Y07	Y403	Sugiyama	VRK2	KLIGLMNNEAAQEstRRRQKyQEsQEPLNEVNSFPQKISYT
Q8IWS0	T358	Sugiyama	PHF6 CENP-31 KIAA1823	EDEERESKsRGKVEIDQQQLtQQQLNGN_____________
Q96EV8	S297	SIGNOR\|PSP	DTNBP1 BLOC1S8 My031	CQNEITLQVPNPSELRAKPPssssTCTDSATRDIsEGGEsP
Q96EV8	S299	SIGNOR\|PSP	DTNBP1 BLOC1S8 My031	NEITLQVPNPSELRAKPPssssTCTDSATRDIsEGGEsPVV
Q9UHP3	S745	SIGNOR\|EPSD\|PSP	USP25 USP21	SEtSVTTAQAAGDPEyLEQPsRSDFSKHLKEETIQIITKAS
Q9UHP3	T680	SIGNOR\|EPSD\|PSP	USP25 USP21	QFLIQEEFNKETGQPLVGIEtLPPDLRDFVEEDNQRFEKEL
Q9UHP3	T727	SIGNOR\|EPSD\|PSP	USP25 USP21	LAQKALQEKLLASQKLRESEtSVTTAQAAGDPEyLEQPsRS
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000001	5.852	0
Signal Transduction	R-HSA-162582	0.000001	5.906	1
Apoptotic execution phase	R-HSA-75153	0.000007	5.164	0
Chromatin organization	R-HSA-4839726	0.000084	4.075	0
Chromatin modifying enzymes	R-HSA-3247509	0.000083	4.080	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.000194	3.711	0
mRNA Splicing - Major Pathway	R-HSA-72163	0.000252	3.598	0
PKMTs methylate histone lysines	R-HSA-3214841	0.000329	3.483	0
mRNA Splicing	R-HSA-72172	0.000491	3.309	0
Signaling by Hippo	R-HSA-2028269	0.000482	3.317	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.001019	2.992	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.001520	2.818	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.001889	2.724	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.002768	2.558	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.003612	2.442	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.003612	2.442	0
Diseases of Telomere Maintenance	R-HSA-9673013	0.003612	2.442	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.003612	2.442	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.003612	2.442	0
MITF-M-dependent gene expression	R-HSA-9856651	0.003655	2.437	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	0.003806	2.420	0
PTEN Regulation	R-HSA-6807070	0.004403	2.356	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.005144	2.289	0
Transcriptional Regulation by VENTX	R-HSA-8853884	0.005799	2.237	0
Apoptosis	R-HSA-109581	0.006887	2.162	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.007230	2.141	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.007775	2.109	0
Signaling by NTRKs	R-HSA-166520	0.007570	2.121	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.008074	2.093	0
Notch-HLH transcription pathway	R-HSA-350054	0.008373	2.077	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.008348	2.078	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.009067	2.043	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.010301	1.987	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	0.010144	1.994	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.010209	1.991	0
Signalling to ERKs	R-HSA-187687	0.011308	1.947	0
Regulation of PTEN gene transcription	R-HSA-8943724	0.011239	1.949	0
ATP-dependent chromatin remodelers	R-HSA-9932444	0.012538	1.902	0
SWI/SNF chromatin remodelers	R-HSA-9932451	0.012538	1.902	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.012105	1.917	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.012105	1.917	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.011801	1.928	0
ISG15 antiviral mechanism	R-HSA-1169408	0.012107	1.917	0
Regulation of TP53 Expression	R-HSA-6804754	0.013641	1.865	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.013920	1.856	0
Myogenesis	R-HSA-525793	0.014190	1.848	0
Cell junction organization	R-HSA-446728	0.013777	1.861	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.014190	1.848	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.016914	1.772	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.015974	1.797	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.015974	1.797	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.016340	1.787	0
Cellular Senescence	R-HSA-2559583	0.016346	1.787	0
Mitotic Prophase	R-HSA-68875	0.016822	1.774	0
Uptake and function of anthrax toxins	R-HSA-5210891	0.016734	1.776	0
Cell Cycle	R-HSA-1640170	0.014542	1.837	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.017526	1.756	0
Signaling by ALK in cancer	R-HSA-9700206	0.017526	1.756	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.018568	1.731	0
Metabolism of RNA	R-HSA-8953854	0.017635	1.754	0
Cell-cell junction organization	R-HSA-421270	0.018289	1.738	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.018618	1.730	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.018618	1.730	0
MET interacts with TNS proteins	R-HSA-8875513	0.020712	1.684	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.020124	1.696	0
Adherens junctions interactions	R-HSA-418990	0.019656	1.707	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.022244	1.653	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.024640	1.608	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.024640	1.608	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.024187	1.616	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.024623	1.609	0
Amplification of signal from the kinetochores	R-HSA-141424	0.024623	1.609	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	0.024350	1.613	0
MTOR signalling	R-HSA-165159	0.024187	1.616	0
Suppression of apoptosis	R-HSA-9635465	0.024350	1.613	0
NRAGE signals death through JNK	R-HSA-193648	0.024231	1.616	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.025231	1.598	0
Nuclear Envelope Breakdown	R-HSA-2980766	0.026048	1.584	0
Transcriptional regulation by RUNX1	R-HSA-8878171	0.026076	1.584	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.026498	1.577	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.027957	1.554	0
Signalling to RAS	R-HSA-167044	0.028545	1.544	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	0.028545	1.544	0
Cell Cycle, Mitotic	R-HSA-69278	0.029085	1.536	0
Oxidative Stress Induced Senescence	R-HSA-2559580	0.029460	1.531	0
SHC-related events triggered by IGF1R	R-HSA-2428933	0.034123	1.467	0
IPs transport between nucleus and cytosol	R-HSA-1855170	0.029912	1.524	0
Signaling downstream of RAS mutants	R-HSA-9649948	0.033301	1.478	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.033301	1.478	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.033301	1.478	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.030001	1.523	0
Signaling by RAS mutants	R-HSA-6802949	0.033301	1.478	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.034400	1.463	0
Regulation of MECP2 expression and activity	R-HSA-9022692	0.029912	1.524	0
M Phase	R-HSA-68886	0.034861	1.458	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.032795	1.484	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.033974	1.469	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.030842	1.511	0
Signaling by LTK	R-HSA-9842663	0.034123	1.467	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.032106	1.493	0
MITF-M-regulated melanocyte development	R-HSA-9730414	0.030645	1.514	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	0.042837	1.368	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.042837	1.368	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	0.042837	1.368	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	0.042837	1.368	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	0.039661	1.402	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.039064	1.408	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.039661	1.402	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.037936	1.421	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	0.038350	1.416	0
mTORC1-mediated signalling	R-HSA-166208	0.035916	1.445	0
Oncogene Induced Senescence	R-HSA-2559585	0.039064	1.408	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	0.038350	1.416	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.038591	1.414	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.039976	1.398	0
PIP3 activates AKT signaling	R-HSA-1257604	0.040605	1.391	0
Cellular response to heat stress	R-HSA-3371556	0.038362	1.416	0
G alpha (12/13) signalling events	R-HSA-416482	0.037936	1.421	0
Cellular responses to stress	R-HSA-2262752	0.036357	1.439	0
Nervous system development	R-HSA-9675108	0.040337	1.394	0
Gene Silencing by RNA	R-HSA-211000	0.039497	1.403	0
Axon guidance	R-HSA-422475	0.042248	1.374	0
Semaphorin interactions	R-HSA-373755	0.038917	1.410	0
Nuclear import of Rev protein	R-HSA-180746	0.035845	1.446	0
NGF-stimulated transcription	R-HSA-9031628	0.038591	1.414	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.035922	1.445	0
Programmed Cell Death	R-HSA-5357801	0.042587	1.371	0
Cell-Cell communication	R-HSA-1500931	0.043204	1.364	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.045624	1.341	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.048692	1.313	0
TGFBR3 expression	R-HSA-9839394	0.048847	1.311	0
HSF1-dependent transactivation	R-HSA-3371571	0.047480	1.323	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.048692	1.313	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.048692	1.313	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.046015	1.337	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.048532	1.314	0
HDMs demethylate histones	R-HSA-3214842	0.048847	1.311	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	0.048692	1.313	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	0.048692	1.313	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.045307	1.344	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.046015	1.337	0
MyD88-independent TLR4 cascade	R-HSA-166166	0.045307	1.344	0
Interleukin-7 signaling	R-HSA-1266695	0.048847	1.311	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.049750	1.303	0
Formation of RNA Pol II elongation complex	R-HSA-112382	0.050702	1.295	0
Erythropoietin activates RAS	R-HSA-9027284	0.052004	1.284	0
p38MAPK events	R-HSA-171007	0.052004	1.284	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.059912	1.222	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.054054	1.267	0
Mitotic Spindle Checkpoint	R-HSA-69618	0.058667	1.232	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.053608	1.271	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.053608	1.271	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.053608	1.271	0
Transcriptional Regulation by E2F6	R-HSA-8953750	0.053657	1.270	0
Interactions of Rev with host cellular proteins	R-HSA-177243	0.057737	1.239	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.057737	1.239	0
MAPK6/MAPK4 signaling	R-HSA-5687128	0.054980	1.260	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.053657	1.270	0
XBP1(S) activates chaperone genes	R-HSA-381038	0.060620	1.217	0
p75 NTR receptor-mediated signalling	R-HSA-193704	0.056101	1.251	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.061991	1.208	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.061991	1.208	0
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	0.083842	1.077	0
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	0.083842	1.077	0
Signaling by TCF7L2 mutants	R-HSA-5339700	0.123093	0.910	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	0.123093	0.910	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	0.123093	0.910	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	0.123093	0.910	0
XAV939 stabilizes AXIN	R-HSA-5545619	0.123093	0.910	0
Defective ALG1 causes CDG-1k	R-HSA-4549380	0.123093	0.910	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	0.123093	0.910	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	0.123093	0.910	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.160664	0.794	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.160664	0.794	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.160664	0.794	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.160664	0.794	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.160664	0.794	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.160664	0.794	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.160664	0.794	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.160664	0.794	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.160664	0.794	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.160664	0.794	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.160664	0.794	0
RUNX3 regulates WNT signaling	R-HSA-8951430	0.071918	1.143	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.071918	1.143	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.071918	1.143	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	0.196628	0.706	0
Classical Kir channels	R-HSA-1296053	0.196628	0.706	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	0.196628	0.706	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	0.084620	1.073	0
Lipophagy	R-HSA-9613354	0.097937	1.009	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	0.231053	0.636	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	0.231053	0.636	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	0.231053	0.636	0
Signaling by MAP2K mutants	R-HSA-9652169	0.231053	0.636	0
Defective LFNG causes SCDO3	R-HSA-5083630	0.231053	0.636	0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	0.231053	0.636	0
Activated NTRK3 signals through RAS	R-HSA-9034864	0.126121	0.899	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	0.126121	0.899	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	0.264004	0.578	0
IRS activation	R-HSA-74713	0.264004	0.578	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.264004	0.578	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.073528	1.134	0
Activated NTRK2 signals through RAS	R-HSA-9026519	0.140851	0.851	0
Ephrin signaling	R-HSA-3928664	0.081454	1.089	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	0.155924	0.807	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.155924	0.807	0
IkBA variant leads to EDA-ID	R-HSA-5603029	0.295546	0.529	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.295546	0.529	0
Phosphorylation of Emi1	R-HSA-176417	0.295546	0.529	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	0.295546	0.529	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.171283	0.766	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.107271	0.970	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	0.107271	0.970	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	0.116503	0.934	0
Erythropoietin activates STAT5	R-HSA-9027283	0.325738	0.487	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	0.325738	0.487	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	0.202657	0.693	0
Signaling by RAF1 mutants	R-HSA-9656223	0.066416	1.178	0
Deadenylation of mRNA	R-HSA-429947	0.145840	0.836	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	0.218579	0.660	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.218579	0.660	0
Phase 4 - resting membrane potential	R-HSA-5576886	0.218579	0.660	0
Defective GALNT3 causes HFTC	R-HSA-5083625	0.218579	0.660	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	0.218579	0.660	0
Glycoprotein hormones	R-HSA-209822	0.354637	0.450	0
IFNG signaling activates MAPKs	R-HSA-9732724	0.354637	0.450	0
SOS-mediated signalling	R-HSA-112412	0.354637	0.450	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	0.354637	0.450	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	0.354637	0.450	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	0.354637	0.450	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	0.354637	0.450	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.354637	0.450	0
Interaction between L1 and Ankyrins	R-HSA-445095	0.177280	0.751	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	0.250688	0.601	0
MET receptor recycling	R-HSA-8875656	0.382300	0.418	0
Signaling by MRAS-complex mutants	R-HSA-9660537	0.382300	0.418	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.382300	0.418	0
HIV elongation arrest and recovery	R-HSA-167287	0.188147	0.726	0
Formation of the Early Elongation Complex	R-HSA-113418	0.188147	0.726	0
Pausing and recovery of HIV elongation	R-HSA-167290	0.188147	0.726	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.068419	1.165	0
Signaling by Erythropoietin	R-HSA-9006335	0.199180	0.701	0
Late endosomal microautophagy	R-HSA-9615710	0.199180	0.701	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.153178	0.815	0
DAP12 signaling	R-HSA-2424491	0.210363	0.677	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.210363	0.677	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.282912	0.548	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	0.408778	0.389	0
ARMS-mediated activation	R-HSA-170984	0.408778	0.389	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	0.408778	0.389	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.104485	0.981	0
MAP2K and MAPK activation	R-HSA-5674135	0.169741	0.770	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	0.298989	0.524	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.298989	0.524	0
HDACs deacetylate histones	R-HSA-3214815	0.145498	0.837	0
Diseases of mitotic cell cycle	R-HSA-9675126	0.233113	0.632	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.103959	0.983	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	0.315007	0.502	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	0.315007	0.502	0
MET activates RAP1 and RAC1	R-HSA-8875555	0.434123	0.362	0
MAPK3 (ERK1) activation	R-HSA-110056	0.434123	0.362	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.434123	0.362	0
Folding of actin by CCT/TriC	R-HSA-390450	0.434123	0.362	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.166159	0.779	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.166159	0.779	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	0.256274	0.591	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.330941	0.480	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	0.330941	0.480	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.330941	0.480	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.180540	0.743	0
Signaling by NOTCH2	R-HSA-1980145	0.267972	0.572	0
Dual Incision in GG-NER	R-HSA-5696400	0.267972	0.572	0
FGFR2 alternative splicing	R-HSA-6803529	0.346769	0.460	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.158448	0.800	0
Regulation of PTEN mRNA translation	R-HSA-8943723	0.362470	0.441	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.362470	0.441	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.362470	0.441	0
Termination of O-glycan biosynthesis	R-HSA-977068	0.362470	0.441	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.155443	0.808	0
TRAF6 mediated NF-kB activation	R-HSA-933542	0.378027	0.422	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	0.378027	0.422	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.181075	0.742	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.181075	0.742	0
Translation initiation complex formation	R-HSA-72649	0.288963	0.539	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.338957	0.470	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.338957	0.470	0
Ribosomal scanning and start codon recognition	R-HSA-72702	0.308411	0.511	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	0.350807	0.455	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.362632	0.441	0
HIV Transcription Initiation	R-HSA-167161	0.362632	0.441	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.362632	0.441	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	0.423675	0.373	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.423675	0.373	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.423675	0.373	0
RNA Polymerase II Promoter Escape	R-HSA-73776	0.386170	0.413	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.275343	0.560	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.275343	0.560	0
Formation of a pool of free 40S subunits	R-HSA-72689	0.321077	0.493	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.409497	0.388	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.379245	0.421	0
Transcription of the HIV genome	R-HSA-167172	0.119951	0.921	0
Formation of definitive endoderm	R-HSA-9823730	0.298989	0.524	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.127296	0.895	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	0.210363	0.677	0
Condensation of Prophase Chromosomes	R-HSA-2299718	0.091091	1.041	0
VxPx cargo-targeting to cilium	R-HSA-5620916	0.298989	0.524	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	0.315007	0.502	0
Regulation of endogenous retroelements	R-HSA-9842860	0.374745	0.426	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.338957	0.470	0
HIV Transcription Elongation	R-HSA-167169	0.338957	0.470	0
Signal attenuation	R-HSA-74749	0.111795	0.952	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.098341	1.007	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	0.354637	0.450	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.210363	0.677	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.393758	0.405	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.253871	0.595	0
Leishmania phagocytosis	R-HSA-9664417	0.253871	0.595	0
Parasite infection	R-HSA-9664407	0.253871	0.595	0
CD28 dependent Vav1 pathway	R-HSA-389359	0.171283	0.766	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.129582	0.887	0
Oncogenic MAPK signaling	R-HSA-6802957	0.117664	0.929	0
Eukaryotic Translation Initiation	R-HSA-72613	0.214059	0.669	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.152257	0.817	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.323769	0.490	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	0.084620	1.073	0
Signaling by Activin	R-HSA-1502540	0.202657	0.693	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.188147	0.726	0
Transcriptional regulation by small RNAs	R-HSA-5578749	0.064997	1.187	0
PI3K/AKT activation	R-HSA-198203	0.434123	0.362	0
Peptide hormone biosynthesis	R-HSA-209952	0.434123	0.362	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.330941	0.480	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	0.315228	0.501	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.327094	0.485	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.338957	0.470	0
Peptide chain elongation	R-HSA-156902	0.419391	0.377	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.126020	0.900	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.233113	0.632	0
Cap-dependent Translation Initiation	R-HSA-72737	0.214059	0.669	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.076929	1.114	0
EPHB-mediated forward signaling	R-HSA-3928662	0.397864	0.400	0
EPH-Ephrin signaling	R-HSA-2682334	0.290919	0.536	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.248895	0.604	0
Activation of HOX genes during differentiation	R-HSA-5619507	0.248895	0.604	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	0.155924	0.807	0
Integrin signaling	R-HSA-354192	0.094070	1.027	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.234602	0.630	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.122079	0.913	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	0.382300	0.418	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.330941	0.480	0
Epigenetic regulation of gene expression	R-HSA-212165	0.336461	0.473	0
Germ layer formation at gastrulation	R-HSA-9754189	0.089730	1.047	0
Repression of WNT target genes	R-HSA-4641265	0.155924	0.807	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.116503	0.934	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.081200	1.090	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.081200	1.090	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.081200	1.090	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.081200	1.090	0
Long-term potentiation	R-HSA-9620244	0.393423	0.405	0
Regulation of TP53 Activity	R-HSA-5633007	0.096374	1.016	0
Signaling by BMP	R-HSA-201451	0.423675	0.373	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.085822	1.066	0
Transcriptional Regulation by TP53	R-HSA-3700989	0.126825	0.897	0
Signaling by WNT in cancer	R-HSA-4791275	0.233113	0.632	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.102505	0.989	0
Calcineurin activates NFAT	R-HSA-2025928	0.097937	1.009	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	0.081454	1.089	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.186877	0.728	0
PTK6 Expression	R-HSA-8849473	0.354637	0.450	0
RAF activation	R-HSA-5673000	0.107661	0.968	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.129582	0.887	0
Signaling by NODAL	R-HSA-1181150	0.298989	0.524	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.267972	0.572	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.241270	0.617	0
Tight junction interactions	R-HSA-420029	0.393423	0.405	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.259508	0.586	0
IGF1R signaling cascade	R-HSA-2428924	0.386902	0.412	0
Chaperone Mediated Autophagy	R-HSA-9613829	0.081454	1.089	0
Rab regulation of trafficking	R-HSA-9007101	0.219769	0.658	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	0.171283	0.766	0
DNA Double Strand Break Response	R-HSA-5693606	0.114675	0.941	0
Separation of Sister Chromatids	R-HSA-2467813	0.278695	0.555	0
Meiosis	R-HSA-1500620	0.385189	0.414	0
Signaling by NOTCH3	R-HSA-9012852	0.298668	0.525	0
Signaling by NOTCH	R-HSA-157118	0.069596	1.157	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.378027	0.422	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.109519	0.961	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.119951	0.921	0
Late Phase of HIV Life Cycle	R-HSA-162599	0.097805	1.010	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	0.231053	0.636	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	0.231053	0.636	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.186877	0.728	0
CRMPs in Sema3A signaling	R-HSA-399956	0.186877	0.728	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	0.325738	0.487	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.166595	0.778	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.346769	0.460	0
Attenuation phase	R-HSA-3371568	0.338957	0.470	0
Clathrin-mediated endocytosis	R-HSA-8856828	0.276648	0.558	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.159146	0.798	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.081200	1.090	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.160425	0.795	0
MET promotes cell motility	R-HSA-8875878	0.315228	0.501	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	0.408644	0.389	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.408644	0.389	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.328690	0.483	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.396686	0.402	0
Mitophagy	R-HSA-5205647	0.267972	0.572	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	0.065969	1.181	0
Adipogenesis	R-HSA-9843745	0.317494	0.498	0
Regulation of PTEN stability and activity	R-HSA-8948751	0.132381	0.878	0
Signaling by Nuclear Receptors	R-HSA-9006931	0.083043	1.081	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.266802	0.574	0
G1 Phase	R-HSA-69236	0.195675	0.708	0
Cyclin D associated events in G1	R-HSA-69231	0.195675	0.708	0
Negative regulation of MAPK pathway	R-HSA-5675221	0.362632	0.441	0
Prolonged ERK activation events	R-HSA-169893	0.218579	0.660	0
DNA Double-Strand Break Repair	R-HSA-5693532	0.077363	1.111	0
Co-inhibition by PD-1	R-HSA-389948	0.256407	0.591	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.220551	0.656	0
DAP12 interactions	R-HSA-2172127	0.397864	0.400	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.327094	0.485	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.160664	0.794	0
TGFBR3 regulates activin signaling	R-HSA-9839406	0.160664	0.794	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.196628	0.706	0
Inactivation of CDC42 and RAC1	R-HSA-428543	0.097937	1.009	0
Alanine metabolism	R-HSA-8964540	0.231053	0.636	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.231053	0.636	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	0.155924	0.807	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	0.155924	0.807	0
Pentose phosphate pathway disease	R-HSA-6791465	0.295546	0.529	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	0.295546	0.529	0
NADPH regeneration	R-HSA-389542	0.325738	0.487	0
G2/M DNA replication checkpoint	R-HSA-69478	0.325738	0.487	0
Cell-extracellular matrix interactions	R-HSA-446353	0.202657	0.693	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.085822	1.066	0
Gap junction degradation	R-HSA-190873	0.408778	0.389	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	0.434123	0.362	0
DNA replication initiation	R-HSA-68952	0.434123	0.362	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.330941	0.480	0
Estrogen-dependent gene expression	R-HSA-9018519	0.077529	1.111	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.127177	0.896	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.378027	0.422	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	0.393423	0.405	0
Mitotic Anaphase	R-HSA-68882	0.159366	0.798	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.162889	0.788	0
Gene expression (Transcription)	R-HSA-74160	0.198106	0.703	0
Regulation of T cell activation by CD28 family	R-HSA-388841	0.433659	0.363	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.376613	0.424	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.191819	0.717	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.316237	0.500	0
Signaling by TGFB family members	R-HSA-9006936	0.378416	0.422	0
RNA Polymerase II Transcription	R-HSA-73857	0.214873	0.668	0
Homology Directed Repair	R-HSA-5693538	0.225536	0.647	0
Autophagy	R-HSA-9612973	0.146917	0.833	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.279730	0.553	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.098341	1.007	0
Neurofascin interactions	R-HSA-447043	0.325738	0.487	0
Regulation of signaling by CBL	R-HSA-912631	0.282912	0.548	0
Cell Cycle Checkpoints	R-HSA-69620	0.108927	0.963	0
TCF dependent signaling in response to WNT	R-HSA-201681	0.180818	0.743	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.085145	1.070	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	0.222725	0.652	0
Signaling by NOTCH1	R-HSA-1980143	0.166230	0.779	0
Generic Transcription Pathway	R-HSA-212436	0.166089	0.780	0
HIV Life Cycle	R-HSA-162587	0.150846	0.821	0
CHL1 interactions	R-HSA-447041	0.071918	1.143	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	0.097937	1.009	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	0.231053	0.636	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.295546	0.529	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	0.354637	0.450	0
Intracellular signaling by second messengers	R-HSA-9006925	0.080556	1.094	0
Macroautophagy	R-HSA-1632852	0.160204	0.795	0
MAPK family signaling cascades	R-HSA-5683057	0.133056	0.876	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.142217	0.847	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.180540	0.743	0
ESR-mediated signaling	R-HSA-8939211	0.064129	1.193	0
MAP kinase activation	R-HSA-450294	0.085602	1.068	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.088466	1.053	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.393366	0.405	0
Signaling by WNT	R-HSA-195721	0.321905	0.492	0
ER-Phagosome pathway	R-HSA-1236974	0.427897	0.369	0
Transcriptional regulation by RUNX3	R-HSA-8878159	0.336327	0.473	0
Mitotic Prometaphase	R-HSA-68877	0.144225	0.841	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	0.153178	0.815	0
Diseases of Immune System	R-HSA-5260271	0.153178	0.815	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.143042	0.845	0
Selective autophagy	R-HSA-9663891	0.254145	0.595	0
HIV Infection	R-HSA-162906	0.200254	0.698	0
Interleukin-17 signaling	R-HSA-448424	0.130856	0.883	0
Breakdown of the nuclear lamina	R-HSA-352238	0.123093	0.910	0
Intracellular oxygen transport	R-HSA-8981607	0.196628	0.706	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	0.186877	0.728	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	0.354637	0.450	0
VLDL clearance	R-HSA-8964046	0.354637	0.450	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	0.382300	0.418	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.266802	0.574	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.090132	1.045	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	0.408778	0.389	0
Regulation of signaling by NODAL	R-HSA-1433617	0.408778	0.389	0
Nuclear RNA decay	R-HSA-9930044	0.244650	0.611	0
Metabolism of non-coding RNA	R-HSA-194441	0.173291	0.761	0
snRNP Assembly	R-HSA-191859	0.173291	0.761	0
Viral Messenger RNA Synthesis	R-HSA-168325	0.187899	0.726	0
G2/M DNA damage checkpoint	R-HSA-69473	0.291453	0.535	0
Amyloid fiber formation	R-HSA-977225	0.350891	0.455	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.421060	0.376	0
Post NMDA receptor activation events	R-HSA-438064	0.410863	0.386	0
G2/M Checkpoints	R-HSA-69481	0.428637	0.368	0
Developmental Biology	R-HSA-1266738	0.305089	0.516	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.102505	0.989	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.113821	0.944	0
Ub-specific processing proteases	R-HSA-5689880	0.334377	0.476	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.374423	0.427	0
Organelle biogenesis and maintenance	R-HSA-1852241	0.323775	0.490	0
RUNX2 regulates bone development	R-HSA-8941326	0.122079	0.913	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.142767	0.845	0
G2/M Transition	R-HSA-69275	0.193321	0.714	0
Signaling by TGFBR3	R-HSA-9839373	0.091091	1.041	0
Cellular responses to stimuli	R-HSA-8953897	0.140024	0.854	0
Cyclin E associated events during G1/S transition	R-HSA-69202	0.130856	0.883	0
Mitotic G2-G2/M phases	R-HSA-453274	0.201870	0.695	0
Cardiogenesis	R-HSA-9733709	0.244650	0.611	0
Histamine receptors	R-HSA-390650	0.196628	0.706	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	0.325738	0.487	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.100759	0.997	0
Rap1 signalling	R-HSA-392517	0.282912	0.548	0
TBC/RABGAPs	R-HSA-8854214	0.186896	0.728	0
ERK/MAPK targets	R-HSA-198753	0.315007	0.502	0
Signaling by ERBB2	R-HSA-1227986	0.347623	0.459	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.089241	1.049	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.350807	0.455	0
Toll-like Receptor Cascades	R-HSA-168898	0.137363	0.862	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.250688	0.601	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.142217	0.847	0
Signaling by EGFR	R-HSA-177929	0.308411	0.511	0
Deubiquitination	R-HSA-5688426	0.428609	0.368	0
Extra-nuclear estrogen signaling	R-HSA-9009391	0.122747	0.911	0
Circadian clock	R-HSA-9909396	0.119875	0.921	0
The NLRP1 inflammasome	R-HSA-844455	0.196628	0.706	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	0.231053	0.636	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	0.231053	0.636	0
NrCAM interactions	R-HSA-447038	0.264004	0.578	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.264004	0.578	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	0.264004	0.578	0
Phase 3 - rapid repolarisation	R-HSA-5576890	0.354637	0.450	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.064997	1.187	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.199180	0.701	0
WNT mediated activation of DVL	R-HSA-201688	0.408778	0.389	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	0.408778	0.389	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	0.315007	0.502	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.362470	0.441	0
Stimuli-sensing channels	R-HSA-2672351	0.160425	0.795	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.390162	0.409	0
Sema4D in semaphorin signaling	R-HSA-400685	0.156110	0.807	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	0.434123	0.362	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.290304	0.537	0
Maturation of nucleoprotein	R-HSA-9683610	0.171283	0.766	0
Protein methylation	R-HSA-8876725	0.202657	0.693	0
GP1b-IX-V activation signalling	R-HSA-430116	0.408778	0.389	0
Mitochondrial biogenesis	R-HSA-1592230	0.066108	1.180	0
Ca2+ pathway	R-HSA-4086398	0.283094	0.548	0
Host Interactions of HIV factors	R-HSA-162909	0.261212	0.583	0
Ion channel transport	R-HSA-983712	0.305997	0.514	0
Signaling by ROBO receptors	R-HSA-376176	0.181197	0.742	0
Ovarian tumor domain proteases	R-HSA-5689896	0.303370	0.518	0
G1/S Transition	R-HSA-69206	0.414545	0.382	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.094070	1.027	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.330941	0.480	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	0.126121	0.899	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	0.264004	0.578	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	0.295546	0.529	0
Nef and signal transduction	R-HSA-164944	0.325738	0.487	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	0.354637	0.450	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.091091	1.041	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.145139	0.838	0
Heme signaling	R-HSA-9707616	0.090132	1.045	0
Regulated proteolysis of p75NTR	R-HSA-193692	0.408778	0.389	0
Interleukin-1 processing	R-HSA-448706	0.408778	0.389	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	0.434123	0.362	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.088466	1.053	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.402020	0.396	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	0.408644	0.389	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.208406	0.681	0
RMTs methylate histone arginines	R-HSA-3214858	0.080718	1.093	0
Regulation of NPAS4 gene expression	R-HSA-9768759	0.250688	0.601	0
Signal transduction by L1	R-HSA-445144	0.298989	0.524	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.199180	0.701	0
PKR-mediated signaling	R-HSA-9833482	0.191819	0.717	0
Signaling by VEGF	R-HSA-194138	0.273468	0.563	0
Glycolysis	R-HSA-70171	0.118400	0.927	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.094070	1.027	0
Interleukin-1 signaling	R-HSA-9020702	0.223287	0.651	0
Inositol phosphate metabolism	R-HSA-1483249	0.302470	0.519	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.234602	0.630	0
Adrenoceptors	R-HSA-390696	0.382300	0.418	0
Creatine metabolism	R-HSA-71288	0.298989	0.524	0
Apoptosis induced DNA fragmentation	R-HSA-140342	0.434123	0.362	0
FOXO-mediated transcription	R-HSA-9614085	0.210848	0.676	0
SARS-CoV-2-host interactions	R-HSA-9705683	0.403605	0.394	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.099593	1.002	0
Transcriptional Regulation by MECP2	R-HSA-8986944	0.076258	1.118	0
ChREBP activates metabolic gene expression	R-HSA-163765	0.126121	0.899	0
Signaling by PTK6	R-HSA-8848021	0.377098	0.424	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.377098	0.424	0
Glucose metabolism	R-HSA-70326	0.219769	0.658	0
RSV-host interactions	R-HSA-9833110	0.397870	0.400	0
SARS-CoV-1-host interactions	R-HSA-9692914	0.413268	0.384	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	0.295546	0.529	0
TRP channels	R-HSA-3295583	0.166595	0.778	0
Maturation of nucleoprotein	R-HSA-9694631	0.282912	0.548	0
Receptor Mediated Mitophagy	R-HSA-8934903	0.434123	0.362	0
tRNA processing in the nucleus	R-HSA-6784531	0.195364	0.709	0
Signaling by Interleukins	R-HSA-449147	0.086533	1.063	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	0.298989	0.524	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.081454	1.089	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.397864	0.400	0
Influenza Infection	R-HSA-168255	0.254575	0.594	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	0.266802	0.574	0
Response of Mtb to phagocytosis	R-HSA-9637690	0.186896	0.728	0
Cytokine Signaling in Immune system	R-HSA-1280215	0.162840	0.788	0
Interferon Signaling	R-HSA-913531	0.408144	0.389	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	0.186877	0.728	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.354637	0.450	0
Maturation of hRSV A proteins	R-HSA-9828806	0.423675	0.373	0
Uptake and actions of bacterial toxins	R-HSA-5339562	0.269697	0.569	0
TNF signaling	R-HSA-75893	0.308411	0.511	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.377098	0.424	0
NOD1/2 Signaling Pathway	R-HSA-168638	0.107661	0.968	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.143337	0.844	0
Interleukin-2 signaling	R-HSA-9020558	0.126121	0.899	0
Signaling by Leptin	R-HSA-2586552	0.434123	0.362	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.423675	0.373	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	0.382300	0.418	0
Regulation of CDH11 function	R-HSA-9762292	0.434123	0.362	0
Regulation of TNFR1 signaling	R-HSA-5357905	0.421060	0.376	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	0.171283	0.766	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.327094	0.485	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	0.250688	0.601	0
Nuclear signaling by ERBB4	R-HSA-1251985	0.338957	0.470	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.099575	1.002	0
Death Receptor Signaling	R-HSA-73887	0.079920	1.097	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.423675	0.373	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	0.186877	0.728	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	0.408644	0.389	0
IRE1alpha activates chaperones	R-HSA-381070	0.079650	1.099	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	0.282912	0.548	0
Growth hormone receptor signaling	R-HSA-982772	0.362470	0.441	0
SARS-CoV-1 Infection	R-HSA-9678108	0.345774	0.461	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.068419	1.165	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	0.396686	0.402	0
Unfolded Protein Response (UPR)	R-HSA-381119	0.375816	0.425	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.438506	0.358	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	0.438506	0.358	0
Phase 0 - rapid depolarisation	R-HSA-5576892	0.438506	0.358	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.438506	0.358	0
Inflammasomes	R-HSA-622312	0.438506	0.358	0
GPER1 signaling	R-HSA-9634597	0.443947	0.353	0
Gluconeogenesis	R-HSA-70263	0.443947	0.353	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.444833	0.352	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.445115	0.352	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.445941	0.351	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.453126	0.344	0
mRNA Capping	R-HSA-72086	0.453126	0.344	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.453126	0.344	0
Downstream signaling of activated FGFR3	R-HSA-5654708	0.453126	0.344	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.454668	0.342	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.454668	0.342	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	0.458383	0.339	0
Signaling by APC mutants	R-HSA-4839744	0.458383	0.339	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.458383	0.339	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.458383	0.339	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.458383	0.339	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	0.458383	0.339	0
Formation of the posterior neural plate	R-HSA-9832991	0.458383	0.339	0
vRNA Synthesis	R-HSA-192814	0.458383	0.339	0
Hormone ligand-binding receptors	R-HSA-375281	0.458383	0.339	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	0.458383	0.339	0
PECAM1 interactions	R-HSA-210990	0.458383	0.339	0
Prostanoid ligand receptors	R-HSA-391908	0.458383	0.339	0
Eukaryotic Translation Elongation	R-HSA-156842	0.461642	0.336	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.467299	0.330	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.467525	0.330	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.467525	0.330	0
Activation of BH3-only proteins	R-HSA-114452	0.467525	0.330	0
Downstream signaling of activated FGFR4	R-HSA-5654716	0.467525	0.330	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.467525	0.330	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.470337	0.328	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.473605	0.325	0
Protein localization	R-HSA-9609507	0.473762	0.324	0
Meiotic recombination	R-HSA-912446	0.477579	0.321	0
Viral Infection Pathways	R-HSA-9824446	0.477662	0.321	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.480208	0.319	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	0.481604	0.317	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.481604	0.317	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.481604	0.317	0
Signaling by GSK3beta mutants	R-HSA-5339716	0.481604	0.317	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	0.481604	0.317	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	0.481604	0.317	0
Signaling by AMER1 mutants	R-HSA-4839748	0.481604	0.317	0
Signaling by AXIN mutants	R-HSA-4839735	0.481604	0.317	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	0.481604	0.317	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.481604	0.317	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	0.481604	0.317	0
DS-GAG biosynthesis	R-HSA-2022923	0.481604	0.317	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	0.481604	0.317	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	0.481604	0.317	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.481697	0.317	0
Trafficking of AMPA receptors	R-HSA-399719	0.481697	0.317	0
Signaling by ERBB4	R-HSA-1236394	0.482981	0.316	0
RAF/MAP kinase cascade	R-HSA-5673001	0.485381	0.314	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.486564	0.313	0
PPARA activates gene expression	R-HSA-1989781	0.486633	0.313	0
mRNA 3'-end processing	R-HSA-72187	0.488579	0.311	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.489214	0.311	0
Centrosome maturation	R-HSA-380287	0.492290	0.308	0
Cellular response to chemical stress	R-HSA-9711123	0.493936	0.306	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.494782	0.306	0
Eukaryotic Translation Termination	R-HSA-72764	0.494782	0.306	0
G0 and Early G1	R-HSA-1538133	0.495633	0.305	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.499419	0.302	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.499465	0.301	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.499465	0.301	0
Meiotic synapsis	R-HSA-1221632	0.499465	0.301	0
Interleukin-12 signaling	R-HSA-9020591	0.501528	0.300	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.503831	0.298	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.503831	0.298	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.503831	0.298	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.503831	0.298	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.503831	0.298	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.503831	0.298	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.503831	0.298	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	0.503831	0.298	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.503831	0.298	0
MET activates RAS signaling	R-HSA-8851805	0.503831	0.298	0
Interleukin-15 signaling	R-HSA-8983432	0.503831	0.298	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	0.503831	0.298	0
Pervasive developmental disorders	R-HSA-9005895	0.503831	0.298	0
Disorders of Nervous System Development	R-HSA-9697154	0.503831	0.298	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	0.503831	0.298	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	0.503831	0.298	0
p75NTR recruits signalling complexes	R-HSA-209543	0.503831	0.298	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.503831	0.298	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.503831	0.298	0
L1CAM interactions	R-HSA-373760	0.504057	0.298	0
Beta-catenin independent WNT signaling	R-HSA-3858494	0.504978	0.297	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.509329	0.293	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.509329	0.293	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.509329	0.293	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.509329	0.293	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.511067	0.292	0
Ribosome-associated quality control	R-HSA-9948299	0.518524	0.285	0
MAPK1/MAPK3 signaling	R-HSA-5684996	0.518820	0.285	0
Nuclear Receptor transcription pathway	R-HSA-383280	0.519779	0.284	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.522778	0.282	0
Resolution of D-Loop Structures	R-HSA-5693537	0.522778	0.282	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.522778	0.282	0
Platelet activation, signaling and aggregation	R-HSA-76002	0.523594	0.281	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.525106	0.280	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.525106	0.280	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	0.525106	0.280	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.525106	0.280	0
Frs2-mediated activation	R-HSA-170968	0.525106	0.280	0
Mtb iron assimilation by chelation	R-HSA-1222449	0.525106	0.280	0
Formation of axial mesoderm	R-HSA-9796292	0.525106	0.280	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	0.525106	0.280	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.528785	0.277	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.531394	0.275	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	0.531394	0.275	0
Hedgehog 'off' state	R-HSA-5610787	0.535081	0.272	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	0.535978	0.271	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.535978	0.271	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.535978	0.271	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.535978	0.271	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	0.535978	0.271	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.535978	0.271	0
Signaling by MET	R-HSA-6806834	0.537709	0.269	0
Signaling by FGFR2	R-HSA-5654738	0.537709	0.269	0
Selenocysteine synthesis	R-HSA-2408557	0.542966	0.265	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	0.545471	0.263	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	0.545471	0.263	0
cGMP effects	R-HSA-418457	0.545471	0.263	0
Regulation of KIT signaling	R-HSA-1433559	0.545471	0.263	0
Malate-aspartate shuttle	R-HSA-9856872	0.545471	0.263	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	0.545471	0.263	0
Synthesis of IPs in the nucleus	R-HSA-1855191	0.545471	0.263	0
Processing of DNA double-strand break ends	R-HSA-5693607	0.546546	0.262	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.548924	0.260	0
Downstream signaling of activated FGFR2	R-HSA-5654696	0.548924	0.260	0
Downstream signaling of activated FGFR1	R-HSA-5654687	0.548924	0.260	0
SARS-CoV-2 Infection	R-HSA-9694516	0.549880	0.260	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.550788	0.259	0
Dual incision in TC-NER	R-HSA-6782135	0.552033	0.258	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.553466	0.257	0
Viral mRNA Translation	R-HSA-192823	0.558544	0.253	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.561615	0.251	0
RNA Polymerase III Transcription	R-HSA-74158	0.561615	0.251	0
Regulation of TP53 Degradation	R-HSA-6804757	0.561615	0.251	0
RET signaling	R-HSA-8853659	0.561615	0.251	0
GPVI-mediated activation cascade	R-HSA-114604	0.561615	0.251	0
G1/S-Specific Transcription	R-HSA-69205	0.561615	0.251	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	0.561615	0.251	0
Formation of the cornified envelope	R-HSA-6809371	0.561715	0.250	0
Deadenylation-dependent mRNA decay	R-HSA-429914	0.562148	0.250	0
Cytoprotection by HMOX1	R-HSA-9707564	0.563953	0.249	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	0.564963	0.248	0
SHC1 events in EGFR signaling	R-HSA-180336	0.564963	0.248	0
Beta-catenin phosphorylation cascade	R-HSA-196299	0.564963	0.248	0
RNA Polymerase III Chain Elongation	R-HSA-73780	0.564963	0.248	0
G beta:gamma signalling through BTK	R-HSA-8964315	0.564963	0.248	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	0.564963	0.248	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	0.564963	0.248	0
Formation of the anterior neural plate	R-HSA-9823739	0.564963	0.248	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.564963	0.248	0
Lysosphingolipid and LPA receptors	R-HSA-419408	0.564963	0.248	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	0.564963	0.248	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	0.564963	0.248	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.564963	0.248	0
DCC mediated attractive signaling	R-HSA-418885	0.564963	0.248	0
p75NTR signals via NF-kB	R-HSA-193639	0.564963	0.248	0
DNA Damage Reversal	R-HSA-73942	0.564963	0.248	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.572123	0.243	0
Kinesins	R-HSA-983189	0.572123	0.243	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.572518	0.242	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.574048	0.241	0
Degradation of AXIN	R-HSA-4641257	0.574048	0.241	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.577631	0.238	0
RNA Polymerase II Transcription Termination	R-HSA-73856	0.581956	0.235	0
Formation of paraxial mesoderm	R-HSA-9793380	0.581956	0.235	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.583620	0.234	0
Class I peroxisomal membrane protein import	R-HSA-9603798	0.583620	0.234	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	0.583620	0.234	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.583620	0.234	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.583620	0.234	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	0.583620	0.234	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	0.583620	0.234	0
Regulation of NF-kappa B signaling	R-HSA-9758274	0.583620	0.234	0
Mineralocorticoid biosynthesis	R-HSA-193993	0.583620	0.234	0
Negative regulation of FLT3	R-HSA-9706369	0.583620	0.234	0
S Phase	R-HSA-69242	0.590291	0.229	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.591645	0.228	0
DNA Repair	R-HSA-73894	0.596791	0.224	0
Stabilization of p53	R-HSA-69541	0.598136	0.223	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	0.598136	0.223	0
Signaling by ALK	R-HSA-201556	0.598136	0.223	0
HCMV Early Events	R-HSA-9609690	0.598556	0.223	0
G1/S DNA Damage Checkpoints	R-HSA-69615	0.601187	0.221	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.601187	0.221	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	0.601479	0.221	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	0.601479	0.221	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.601479	0.221	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	0.601479	0.221	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.601479	0.221	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.601479	0.221	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	0.601479	0.221	0
Heme assimilation	R-HSA-9927020	0.601479	0.221	0
Disorders of Developmental Biology	R-HSA-9675151	0.601479	0.221	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	0.601479	0.221	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.601479	0.221	0
Antigen processing-Cross presentation	R-HSA-1236975	0.603616	0.219	0
Chaperonin-mediated protein folding	R-HSA-390466	0.605807	0.218	0
Interleukin-12 family signaling	R-HSA-447115	0.605807	0.218	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.609791	0.215	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.609791	0.215	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.609791	0.215	0
Interleukin-2 family signaling	R-HSA-451927	0.609791	0.215	0
Ion transport by P-type ATPases	R-HSA-936837	0.610581	0.214	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.613878	0.212	0
Interleukin-1 family signaling	R-HSA-446652	0.615028	0.211	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.618572	0.209	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.618572	0.209	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.618572	0.209	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	0.618572	0.209	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.621186	0.207	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.621186	0.207	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.621186	0.207	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	0.621186	0.207	0
FLT3 Signaling	R-HSA-9607240	0.621186	0.207	0
Membrane Trafficking	R-HSA-199991	0.622395	0.206	0
Cardiac conduction	R-HSA-5576891	0.622523	0.206	0
SARS-CoV Infections	R-HSA-9679506	0.625634	0.204	0
AURKA Activation by TPX2	R-HSA-8854518	0.628921	0.201	0
Base Excision Repair	R-HSA-73884	0.629711	0.201	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.632323	0.199	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.632323	0.199	0
Degradation of CRY and PER proteins	R-HSA-9932298	0.632323	0.199	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.632323	0.199	0
Heme biosynthesis	R-HSA-189451	0.632323	0.199	0
Translation of Structural Proteins	R-HSA-9683701	0.632323	0.199	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.632323	0.199	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	0.634933	0.197	0
RNA Polymerase III Transcription Termination	R-HSA-73980	0.634933	0.197	0
Platelet sensitization by LDL	R-HSA-432142	0.634933	0.197	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	0.634933	0.197	0
Synaptic adhesion-like molecules	R-HSA-8849932	0.634933	0.197	0
Tie2 Signaling	R-HSA-210993	0.634933	0.197	0
Polo-like kinase mediated events	R-HSA-156711	0.634933	0.197	0
Vitamin D (calciferol) metabolism	R-HSA-196791	0.634933	0.197	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.637865	0.195	0
Cytosolic tRNA aminoacylation	R-HSA-379716	0.643202	0.192	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.643202	0.192	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	0.643202	0.192	0
Cleavage of the damaged pyrimidine	R-HSA-110329	0.643202	0.192	0
Depyrimidination	R-HSA-73928	0.643202	0.192	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.646656	0.189	0
Cellular response to starvation	R-HSA-9711097	0.650565	0.187	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	0.650594	0.187	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.650594	0.187	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.650594	0.187	0
E2F mediated regulation of DNA replication	R-HSA-113510	0.650594	0.187	0
Specification of the neural plate border	R-HSA-9834899	0.650594	0.187	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	0.650594	0.187	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	0.650594	0.187	0
STING mediated induction of host immune responses	R-HSA-1834941	0.650594	0.187	0
The NLRP3 inflammasome	R-HSA-844456	0.650594	0.187	0
Protein folding	R-HSA-391251	0.652666	0.185	0
Signaling by SCF-KIT	R-HSA-1433557	0.653825	0.185	0
Signaling by FGFR4	R-HSA-5654743	0.653825	0.185	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.663782	0.178	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.663782	0.178	0
Amine ligand-binding receptors	R-HSA-375280	0.664195	0.178	0
Netrin-1 signaling	R-HSA-373752	0.664195	0.178	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	0.665583	0.177	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.665583	0.177	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.665583	0.177	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.665583	0.177	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.665583	0.177	0
Co-inhibition by CTLA4	R-HSA-389513	0.665583	0.177	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.665583	0.177	0
Eicosanoid ligand-binding receptors	R-HSA-391903	0.665583	0.177	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	0.666020	0.177	0
Parasitic Infection Pathways	R-HSA-9824443	0.666676	0.176	0
Leishmania infection	R-HSA-9658195	0.666676	0.176	0
Regulation of mitotic cell cycle	R-HSA-453276	0.672116	0.173	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.672116	0.173	0
NoRC negatively regulates rRNA expression	R-HSA-427413	0.672116	0.173	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	0.672116	0.173	0
Hedgehog 'on' state	R-HSA-5632684	0.672116	0.173	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.672116	0.173	0
Signaling by Hedgehog	R-HSA-5358351	0.672301	0.172	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.674313	0.171	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.674313	0.171	0
Nucleosome assembly	R-HSA-774815	0.674313	0.171	0
Asymmetric localization of PCP proteins	R-HSA-4608870	0.674313	0.171	0
Somitogenesis	R-HSA-9824272	0.674313	0.171	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.674313	0.171	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.674313	0.171	0
Signaling by FGFR3	R-HSA-5654741	0.674313	0.171	0
Degradation of cysteine and homocysteine	R-HSA-1614558	0.674313	0.171	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.679931	0.168	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.679931	0.168	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.679931	0.168	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.679931	0.168	0
Zygotic genome activation (ZGA)	R-HSA-9819196	0.679931	0.168	0
Basigin interactions	R-HSA-210991	0.679931	0.168	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	0.679931	0.168	0
Innate Immune System	R-HSA-168249	0.682700	0.166	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.684182	0.165	0
mRNA Splicing - Minor Pathway	R-HSA-72165	0.684182	0.165	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.688326	0.162	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.688764	0.162	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.688764	0.162	0
Transcriptional regulation by RUNX2	R-HSA-8878166	0.691601	0.160	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	0.693663	0.159	0
Androgen biosynthesis	R-HSA-193048	0.693663	0.159	0
Signaling by PDGFR in disease	R-HSA-9671555	0.693663	0.159	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.693805	0.159	0
Neutrophil degranulation	R-HSA-6798695	0.696187	0.157	0
Signaling by NOTCH4	R-HSA-9013694	0.696203	0.157	0
Signaling by FGFR	R-HSA-190236	0.702437	0.153	0
Co-stimulation by CD28	R-HSA-389356	0.703184	0.153	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.703184	0.153	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	0.703878	0.153	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.703928	0.152	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.703928	0.152	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	0.706807	0.151	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	0.706807	0.151	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.706807	0.151	0
RAF-independent MAPK1/3 activation	R-HSA-112409	0.706807	0.151	0
Signaling by KIT in disease	R-HSA-9669938	0.706807	0.151	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.706807	0.151	0
Reactions specific to the complex N-glycan synthesis pathway	R-HSA-975578	0.706807	0.151	0
LDL clearance	R-HSA-8964038	0.706807	0.151	0
HATs acetylate histones	R-HSA-3214847	0.709109	0.149	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.711502	0.148	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.712323	0.147	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.712323	0.147	0
DNA Damage Bypass	R-HSA-73893	0.712323	0.147	0
Interleukin receptor SHC signaling	R-HSA-912526	0.719388	0.143	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	0.719388	0.143	0
ABC transporters in lipid homeostasis	R-HSA-1369062	0.719388	0.143	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	0.719388	0.143	0
Syndecan interactions	R-HSA-3000170	0.719388	0.143	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.719388	0.143	0
Regulation of RAS by GAPs	R-HSA-5658442	0.721225	0.142	0
C-type lectin receptors (CLRs)	R-HSA-5621481	0.725487	0.139	0
RNA Polymerase I Transcription	R-HSA-73864	0.726202	0.139	0
Integrin cell surface interactions	R-HSA-216083	0.726202	0.139	0
Hedgehog ligand biogenesis	R-HSA-5358346	0.729893	0.137	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	0.731430	0.136	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	0.731430	0.136	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.731430	0.136	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	0.731430	0.136	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.731430	0.136	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	0.731430	0.136	0
Neurodegenerative Diseases	R-HSA-8863678	0.731430	0.136	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.731430	0.136	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.733068	0.135	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.733068	0.135	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.733068	0.135	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.738332	0.132	0
RNA Polymerase I Promoter Escape	R-HSA-73772	0.738332	0.132	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.738332	0.132	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.738332	0.132	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.738332	0.132	0
Gastrulation	R-HSA-9758941	0.738682	0.132	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.740308	0.131	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.742956	0.129	0
G protein gated Potassium channels	R-HSA-1296059	0.742956	0.129	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	0.742956	0.129	0
Activation of G protein gated Potassium channels	R-HSA-1296041	0.742956	0.129	0
Hyaluronan degradation	R-HSA-2160916	0.742956	0.129	0
Acyl chain remodelling of PS	R-HSA-1482801	0.742956	0.129	0
Formation of the nephric duct	R-HSA-9830364	0.742956	0.129	0
Potential therapeutics for SARS	R-HSA-9679191	0.743753	0.129	0
HCMV Infection	R-HSA-9609646	0.743777	0.129	0
Platelet degranulation	R-HSA-114608	0.744141	0.128	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.746545	0.127	0
Nucleotide biosynthesis	R-HSA-8956320	0.746545	0.127	0
Nucleotide Excision Repair	R-HSA-5696398	0.752762	0.123	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.753988	0.123	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	0.753988	0.123	0
Signaling by EGFR in Cancer	R-HSA-1643713	0.753988	0.123	0
Suppression of phagosomal maturation	R-HSA-9637687	0.753988	0.123	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.754535	0.122	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.754535	0.122	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.755269	0.122	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.760111	0.119	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.762308	0.118	0
Packaging Of Telomere Ends	R-HSA-171306	0.764547	0.117	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	0.764547	0.117	0
RNA Polymerase I Transcription Termination	R-HSA-73863	0.764547	0.117	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	0.764547	0.117	0
Cristae formation	R-HSA-8949613	0.764547	0.117	0
RNA Polymerase I Promoter Opening	R-HSA-73728	0.764547	0.117	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.764547	0.117	0
EPHA-mediated growth cone collapse	R-HSA-3928663	0.764547	0.117	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.764547	0.117	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.764547	0.117	0
Reproduction	R-HSA-1474165	0.765265	0.116	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.766784	0.115	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.769866	0.114	0
Ion homeostasis	R-HSA-5578775	0.769866	0.114	0
Signaling by FGFR1	R-HSA-5654736	0.769866	0.114	0
rRNA processing	R-HSA-72312	0.773012	0.112	0
Pyrimidine salvage	R-HSA-73614	0.774654	0.111	0
Pyroptosis	R-HSA-5620971	0.774654	0.111	0
Dectin-2 family	R-HSA-5621480	0.777213	0.109	0
HCMV Late Events	R-HSA-9610379	0.777271	0.109	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.779175	0.108	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.780223	0.108	0
Infectious disease	R-HSA-5663205	0.783004	0.106	0
DNA methylation	R-HSA-5334118	0.784327	0.106	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.784327	0.106	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.784327	0.106	0
Termination of translesion DNA synthesis	R-HSA-5656169	0.784327	0.106	0
Thyroxine biosynthesis	R-HSA-209968	0.784327	0.106	0
Platelet calcium homeostasis	R-HSA-418360	0.784327	0.106	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	0.784327	0.106	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.784355	0.105	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.785165	0.105	0
FCERI mediated MAPK activation	R-HSA-2871796	0.791199	0.102	0
Peroxisomal protein import	R-HSA-9033241	0.791295	0.102	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.793585	0.100	0
Activation of the pre-replicative complex	R-HSA-68962	0.793585	0.100	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	0.793585	0.100	0
Downregulation of ERBB2 signaling	R-HSA-8863795	0.793585	0.100	0
Neurotransmitter clearance	R-HSA-112311	0.793585	0.100	0
Diseases of programmed cell death	R-HSA-9645723	0.796742	0.099	0
RAB geranylgeranylation	R-HSA-8873719	0.798037	0.098	0
tRNA Aminoacylation	R-HSA-379724	0.798037	0.098	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	0.802447	0.096	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.802447	0.096	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	0.802447	0.096	0
EGFR downregulation	R-HSA-182971	0.802447	0.096	0
Cargo concentration in the ER	R-HSA-5694530	0.802447	0.096	0
Evasion by RSV of host interferon responses	R-HSA-9833109	0.802447	0.096	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.802447	0.096	0
Downstream signal transduction	R-HSA-186763	0.802447	0.096	0
Molecules associated with elastic fibres	R-HSA-2129379	0.802447	0.096	0
Aspartate and asparagine metabolism	R-HSA-8963693	0.802447	0.096	0
Selenoamino acid metabolism	R-HSA-2408522	0.807385	0.093	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.807792	0.093	0
Cilium Assembly	R-HSA-5617833	0.808336	0.092	0
Inwardly rectifying K+ channels	R-HSA-1296065	0.810929	0.091	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.810929	0.091	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	0.810929	0.091	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.810944	0.091	0
Mitochondrial protein import	R-HSA-1268020	0.810944	0.091	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.810944	0.091	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.810944	0.091	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.817118	0.088	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.817118	0.088	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.819047	0.087	0
G-protein beta:gamma signalling	R-HSA-397795	0.819047	0.087	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	0.819047	0.087	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.819047	0.087	0
SLC transporter disorders	R-HSA-5619102	0.819280	0.087	0
Insulin receptor signalling cascade	R-HSA-74751	0.823111	0.085	0
Peptide hormone metabolism	R-HSA-2980736	0.824697	0.084	0
Striated Muscle Contraction	R-HSA-390522	0.826817	0.083	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	0.826817	0.083	0
Vpu mediated degradation of CD4	R-HSA-180534	0.826817	0.083	0
Miscellaneous transport and binding events	R-HSA-5223345	0.826817	0.083	0
Effects of PIP2 hydrolysis	R-HSA-114508	0.826817	0.083	0
Glutamate and glutamine metabolism	R-HSA-8964539	0.826817	0.083	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	0.826817	0.083	0
Cellular response to hypoxia	R-HSA-1234174	0.828927	0.081	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.829100	0.081	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.833219	0.079	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.834254	0.079	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.834254	0.079	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	0.834254	0.079	0
Hyaluronan metabolism	R-HSA-2142845	0.834254	0.079	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.834254	0.079	0
Signal amplification	R-HSA-392518	0.834254	0.079	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	0.834254	0.079	0
Immune System	R-HSA-168256	0.834552	0.079	0
Hemostasis	R-HSA-109582	0.839689	0.076	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.841371	0.075	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.841371	0.075	0
Regulation of Apoptosis	R-HSA-169911	0.841371	0.075	0
Chromosome Maintenance	R-HSA-73886	0.841760	0.075	0
O-linked glycosylation of mucins	R-HSA-913709	0.845354	0.073	0
COPI-mediated anterograde transport	R-HSA-6807878	0.847044	0.072	0
PRC2 methylates histones and DNA	R-HSA-212300	0.848184	0.072	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.848184	0.072	0
FLT3 signaling in disease	R-HSA-9682385	0.848184	0.072	0
HSF1 activation	R-HSA-3371511	0.848184	0.072	0
Calmodulin induced events	R-HSA-111933	0.848184	0.072	0
CaM pathway	R-HSA-111997	0.848184	0.072	0
Lysosome Vesicle Biogenesis	R-HSA-432720	0.848184	0.072	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.849755	0.071	0
Telomere Maintenance	R-HSA-157579	0.851427	0.070	0
Voltage gated Potassium channels	R-HSA-1296072	0.854705	0.068	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	0.854705	0.068	0
TRAF6 mediated IRF7 activation	R-HSA-933541	0.854705	0.068	0
Ubiquinol biosynthesis	R-HSA-2142789	0.854705	0.068	0
Degradation of DVL	R-HSA-4641258	0.854705	0.068	0
Cleavage of the damaged purine	R-HSA-110331	0.854705	0.068	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	0.854705	0.068	0
Metabolism of folate and pterines	R-HSA-196757	0.854705	0.068	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.855496	0.068	0
Post-translational protein phosphorylation	R-HSA-8957275	0.855699	0.068	0
Metabolism of cofactors	R-HSA-8978934	0.860336	0.065	0
Metabolism of porphyrins	R-HSA-189445	0.860336	0.065	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.860945	0.065	0
Depurination	R-HSA-73927	0.860945	0.065	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	0.860945	0.065	0
Elastic fibre formation	R-HSA-1566948	0.860945	0.065	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.860945	0.065	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.866918	0.062	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.866918	0.062	0
Pentose phosphate pathway	R-HSA-71336	0.866918	0.062	0
Plasma lipoprotein clearance	R-HSA-8964043	0.866918	0.062	0
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	0.866918	0.062	0
Developmental Cell Lineages	R-HSA-9734767	0.871121	0.060	0
PI Metabolism	R-HSA-1483255	0.871732	0.060	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	0.872635	0.059	0
Generation of second messenger molecules	R-HSA-202433	0.872635	0.059	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.872635	0.059	0
Aggrephagy	R-HSA-9646399	0.872635	0.059	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.872635	0.059	0
N-glycan antennae elongation in the medial/trans-Golgi	R-HSA-975576	0.872635	0.059	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	0.878107	0.056	0
Hh mutants are degraded by ERAD	R-HSA-5362768	0.878107	0.056	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.878107	0.056	0
Citric acid cycle (TCA cycle)	R-HSA-71403	0.878247	0.056	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.879142	0.056	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.881237	0.055	0
Muscle contraction	R-HSA-397014	0.881237	0.055	0
UCH proteinases	R-HSA-5689603	0.882381	0.054	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.883344	0.054	0
Intra-Golgi traffic	R-HSA-6811438	0.883344	0.054	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	0.883344	0.054	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.883556	0.054	0
Translation of Structural Proteins	R-HSA-9694635	0.886385	0.052	0
Translation	R-HSA-72766	0.886435	0.052	0
Golgi-to-ER retrograde transport	R-HSA-8856688	0.887849	0.052	0
Activation of GABAB receptors	R-HSA-991365	0.888356	0.051	0
GABA B receptor activation	R-HSA-977444	0.888356	0.051	0
Ca-dependent events	R-HSA-111996	0.888356	0.051	0
Platelet homeostasis	R-HSA-418346	0.889544	0.051	0
PCP/CE pathway	R-HSA-4086400	0.890263	0.050	0
Defective pyroptosis	R-HSA-9710421	0.893153	0.049	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.893153	0.049	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.893153	0.049	0
Proteasome assembly	R-HSA-9907900	0.897744	0.047	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.897744	0.047	0
Gap junction trafficking	R-HSA-190828	0.897744	0.047	0
Methylation	R-HSA-156581	0.897744	0.047	0
Surfactant metabolism	R-HSA-5683826	0.897744	0.047	0
DNA Replication Pre-Initiation	R-HSA-69002	0.899139	0.046	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.902138	0.045	0
DAG and IP3 signaling	R-HSA-1489509	0.902138	0.045	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	0.902138	0.045	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.904576	0.044	0
Antimicrobial peptides	R-HSA-6803157	0.905111	0.043	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.906344	0.043	0
Diseases of DNA repair	R-HSA-9675135	0.906344	0.043	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	0.906344	0.043	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	0.906344	0.043	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.907871	0.042	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.910369	0.041	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.910369	0.041	0
Synthesis of PC	R-HSA-1483191	0.910369	0.041	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	0.910369	0.041	0
Vesicle-mediated transport	R-HSA-5653656	0.911698	0.040	0
Protein-protein interactions at synapses	R-HSA-6794362	0.914145	0.039	0
Intraflagellar transport	R-HSA-5620924	0.914222	0.039	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	0.916107	0.038	0
tRNA processing	R-HSA-72306	0.916295	0.038	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.917077	0.038	0
Degradation of CDH1	R-HSA-9766229	0.917909	0.037	0
Gap junction trafficking and regulation	R-HSA-157858	0.917909	0.037	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	0.917909	0.037	0
Sulfur amino acid metabolism	R-HSA-1614635	0.920016	0.036	0
PI3K Cascade	R-HSA-109704	0.921438	0.036	0
Azathioprine ADME	R-HSA-9748787	0.921438	0.036	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	0.921438	0.036	0
Activation of NF-kappaB in B cells	R-HSA-1169091	0.924815	0.034	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.924815	0.034	0
Orc1 removal from chromatin	R-HSA-68949	0.928047	0.032	0
Neurexins and neuroligins	R-HSA-6794361	0.928047	0.032	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.928047	0.032	0
ER to Golgi Anterograde Transport	R-HSA-199977	0.930173	0.031	0
Keratinization	R-HSA-6805567	0.930184	0.031	0
Downstream TCR signaling	R-HSA-202424	0.930643	0.031	0
Amino acids regulate mTORC1	R-HSA-9639288	0.931141	0.031	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.931141	0.031	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.934102	0.030	0
G alpha (z) signalling events	R-HSA-418597	0.936935	0.028	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	0.936935	0.028	0
Signaling by Insulin receptor	R-HSA-74752	0.937723	0.028	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.937723	0.028	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.939289	0.027	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.939647	0.027	0
Metabolism of amine-derived hormones	R-HSA-209776	0.939647	0.027	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	0.939647	0.027	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.939926	0.027	0
Assembly of the pre-replicative complex	R-HSA-68867	0.939926	0.027	0
Mitochondrial protein degradation	R-HSA-9837999	0.942055	0.026	0
Diseases of glycosylation	R-HSA-3781865	0.942226	0.026	0
IRS-mediated signalling	R-HSA-112399	0.942242	0.026	0
Regulation of CDH1 Function	R-HSA-9764561	0.942242	0.026	0
Synthesis of PA	R-HSA-1483166	0.942242	0.026	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.944113	0.025	0
Disorders of transmembrane transporters	R-HSA-5619115	0.947024	0.024	0
Regulation of beta-cell development	R-HSA-186712	0.947104	0.024	0
Amino acid transport across the plasma membrane	R-HSA-352230	0.947104	0.024	0
Potassium Channels	R-HSA-1296071	0.948021	0.023	0
GABA receptor activation	R-HSA-977443	0.949379	0.023	0
Signaling by Retinoic Acid	R-HSA-5362517	0.949379	0.023	0
Metabolism of polyamines	R-HSA-351202	0.949379	0.023	0
IRS-related events triggered by IGF1R	R-HSA-2428928	0.951556	0.022	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.951556	0.022	0
PLC beta mediated events	R-HSA-112043	0.951556	0.022	0
Nucleotide salvage	R-HSA-8956321	0.951556	0.022	0
Collagen degradation	R-HSA-1442490	0.951556	0.022	0
Neddylation	R-HSA-8951664	0.952281	0.021	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.953381	0.021	0
Signaling by PDGF	R-HSA-186797	0.953640	0.021	0
ABC-family proteins mediated transport	R-HSA-382556	0.955070	0.020	0
Complex I biogenesis	R-HSA-6799198	0.955635	0.020	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	0.959370	0.018	0
G-protein mediated events	R-HSA-112040	0.962792	0.016	0
Metabolism of steroid hormones	R-HSA-196071	0.962792	0.016	0
Nicotinate metabolism	R-HSA-196807	0.962792	0.016	0
SLC-mediated transport of amino acids	R-HSA-9958863	0.962792	0.016	0
Kidney development	R-HSA-9830369	0.962792	0.016	0
Integration of energy metabolism	R-HSA-163685	0.963468	0.016	0
Transmission across Chemical Synapses	R-HSA-112315	0.964316	0.016	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.964393	0.016	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	0.964393	0.016	0
Regulated Necrosis	R-HSA-5218859	0.964393	0.016	0
Transport to the Golgi and subsequent modification	R-HSA-948021	0.964868	0.016	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.965925	0.015	0
Synthesis of DNA	R-HSA-69239	0.966522	0.015	0
G alpha (s) signalling events	R-HSA-418555	0.966610	0.015	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.967392	0.014	0
Leishmania parasite growth and survival	R-HSA-9664433	0.968582	0.014	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	0.968582	0.014	0
ECM proteoglycans	R-HSA-3000178	0.968795	0.014	0
Metal ion assimilation from the host	R-HSA-9638482	0.968795	0.014	0
TCR signaling	R-HSA-202403	0.970046	0.013	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.970138	0.013	0
Purine catabolism	R-HSA-74259	0.970138	0.013	0
Switching of origins to a post-replicative state	R-HSA-69052	0.971424	0.013	0
Diseases of carbohydrate metabolism	R-HSA-5663084	0.971424	0.013	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.973831	0.012	0
Protein ubiquitination	R-HSA-8852135	0.973831	0.012	0
Iron uptake and transport	R-HSA-917937	0.973831	0.012	0
Disease	R-HSA-1643685	0.974372	0.011	0
Interferon alpha/beta signaling	R-HSA-909733	0.976933	0.010	0
ABC transporter disorders	R-HSA-5619084	0.977068	0.010	0
Sensory processing of sound	R-HSA-9659379	0.978056	0.010	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.979001	0.009	0
DNA Replication	R-HSA-69306	0.979988	0.009	0
Peroxisomal lipid metabolism	R-HSA-390918	0.982391	0.008	0
MHC class II antigen presentation	R-HSA-2132295	0.982934	0.007	0
Regulation of Complement cascade	R-HSA-977606	0.984179	0.007	0
Phospholipid metabolism	R-HSA-1483257	0.984581	0.007	0
Pyruvate metabolism	R-HSA-70268	0.985235	0.006	0
Bacterial Infection Pathways	R-HSA-9824439	0.985516	0.006	0
Classical antibody-mediated complement activation	R-HSA-173623	0.985872	0.006	0
Nucleotide catabolism	R-HSA-8956319	0.986918	0.006	0
Neurotransmitter release cycle	R-HSA-112310	0.987063	0.006	0
Metabolism of nucleotides	R-HSA-15869	0.987386	0.006	0
Glycerophospholipid biosynthesis	R-HSA-1483206	0.987741	0.005	0
Cell surface interactions at the vascular wall	R-HSA-202733	0.987762	0.005	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.988665	0.005	0
FCGR activation	R-HSA-2029481	0.989153	0.005	0
Post-translational protein modification	R-HSA-597592	0.989194	0.005	0
Collagen formation	R-HSA-1474290	0.989621	0.005	0
Neuronal System	R-HSA-112316	0.990414	0.004	0
Scavenging of heme from plasma	R-HSA-2168880	0.990496	0.004	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	0.990906	0.004	0
O-linked glycosylation	R-HSA-5173105	0.991081	0.004	0
Regulation of insulin secretion	R-HSA-422356	0.991674	0.004	0
Synthesis of bile acids and bile salts	R-HSA-192105	0.992033	0.003	0
Metabolism of steroids	R-HSA-8957322	0.993101	0.003	0
Opioid Signalling	R-HSA-111885	0.993609	0.003	0
Response of endothelial cells to shear stress	R-HSA-9860931	0.993609	0.003	0
Complement cascade	R-HSA-166658	0.993701	0.003	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	0.993760	0.003	0
Extracellular matrix organization	R-HSA-1474244	0.994351	0.002	0
Creation of C4 and C2 activators	R-HSA-166786	0.994401	0.002	0
G alpha (q) signalling events	R-HSA-416476	0.994688	0.002	0
Adaptive Immune System	R-HSA-1280218	0.995167	0.002	0
Bile acid and bile salt metabolism	R-HSA-194068	0.995307	0.002	0
Cellular responses to mechanical stimuli	R-HSA-9855142	0.996066	0.002	0
Initial triggering of complement	R-HSA-166663	0.996236	0.002	0
Interferon gamma signaling	R-HSA-877300	0.996351	0.002	0
Sphingolipid metabolism	R-HSA-428157	0.996416	0.002	0
Role of phospholipids in phagocytosis	R-HSA-2029485	0.996554	0.001	0
GPCR downstream signalling	R-HSA-388396	0.997901	0.001	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	0.997971	0.001	0
Metabolism of proteins	R-HSA-392499	0.998288	0.001	0
Respiratory electron transport	R-HSA-611105	0.998343	0.001	0
Degradation of the extracellular matrix	R-HSA-1474228	0.998511	0.001	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	0.998543	0.001	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	0.998805	0.001	0
Glycosaminoglycan metabolism	R-HSA-1630316	0.999089	0.000	0
FCERI mediated NF-kB activation	R-HSA-2871837	0.999198	0.000	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	0.999385	0.000	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.999437	0.000	0
Arachidonate metabolism	R-HSA-2142753	0.999437	0.000	0
Metabolism of amino acids and derivatives	R-HSA-71291	0.999529	0.000	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	0.999549	0.000	0
Signaling by GPCR	R-HSA-372790	0.999696	0.000	0
Diseases of metabolism	R-HSA-5668914	0.999707	0.000	0
Metabolism of vitamins and cofactors	R-HSA-196854	0.999810	0.000	0
G alpha (i) signalling events	R-HSA-418594	0.999837	0.000	0
Asparagine N-linked glycosylation	R-HSA-446203	0.999902	0.000	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	0.999936	0.000	0
Infection with Enterobacteria	R-HSA-9640148	0.999944	0.000	0
Transport of small molecules	R-HSA-382551	0.999971	0.000	0
Drug ADME	R-HSA-9748784	0.999972	0.000	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	0.999983	0.000	0
Phase II - Conjugation of compounds	R-HSA-156580	0.999989	0.000	0
SLC-mediated transmembrane transport	R-HSA-425407	0.999998	0.000	0
Fatty acid metabolism	R-HSA-8978868	0.999999	0.000	0
GPCR ligand binding	R-HSA-500792	1.000000	0.000	0
Metabolism of lipids	R-HSA-556833	1.000000	0.000	0
Biological oxidations	R-HSA-211859	1.000000	0.000	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000	0.000	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000	-0.000	0
Metabolism	R-HSA-1430728	1.000000	-0.000	0
Sensory Perception	R-HSA-9709957	1.000000	-0.000	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path
Cell Cycle	R-HSA-1640170	1.740198e-08	7.759	0
Cell Cycle Checkpoints	R-HSA-69620	5.116684e-08	7.291	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.599248e-07	6.252	0
Regulation of TP53 Activity	R-HSA-5633007	9.579969e-07	6.019	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.101158e-06	5.958	0
Cell Cycle, Mitotic	R-HSA-69278	8.194898e-07	6.086	0
Signaling by ALK in cancer	R-HSA-9700206	1.101158e-06	5.958	0
Metabolism of RNA	R-HSA-8953854	1.288104e-06	5.890	0
M Phase	R-HSA-68886	3.165750e-06	5.500	0
Chromatin organization	R-HSA-4839726	3.189577e-06	5.496	0
Transcriptional Regulation by TP53	R-HSA-3700989	4.478947e-06	5.349	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.329715e-06	5.135	0
Cellular responses to stimuli	R-HSA-8953897	1.404665e-05	4.852	0
Chromatin modifying enzymes	R-HSA-3247509	1.553863e-05	4.809	0
Influenza Infection	R-HSA-168255	1.869110e-05	4.728	0
Cellular Senescence	R-HSA-2559583	2.036426e-05	4.691	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.614910e-05	4.583	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.833046e-05	4.548	0
Cellular responses to stress	R-HSA-2262752	3.026539e-05	4.519	0
FLT3 signaling by CBL mutants	R-HSA-9706377	4.741407e-05	4.324	0
Translation initiation complex formation	R-HSA-72649	4.847458e-05	4.314	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.689298e-05	4.329	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.689298e-05	4.329	0
Eukaryotic Translation Initiation	R-HSA-72613	4.432942e-05	4.353	0
Cap-dependent Translation Initiation	R-HSA-72737	4.432942e-05	4.353	0
SARS-CoV-1-host interactions	R-HSA-9692914	3.763552e-05	4.424	0
G2/M Checkpoints	R-HSA-69481	5.034115e-05	4.298	0
Mitotic Anaphase	R-HSA-68882	5.886211e-05	4.230	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.773466e-05	4.239	0
Eukaryotic Translation Elongation	R-HSA-156842	6.272801e-05	4.203	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.327631e-05	4.199	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.035920e-05	4.153	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.167543e-05	4.145	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.167543e-05	4.145	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.841898e-05	4.053	0
DNA Double Strand Break Response	R-HSA-5693606	8.569768e-05	4.067	0
Apoptosis induced DNA fragmentation	R-HSA-140342	9.216023e-05	4.035	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.989729e-05	4.046	0
Cell-extracellular matrix interactions	R-HSA-446353	9.807014e-05	4.008	0
Spry regulation of FGF signaling	R-HSA-1295596	9.807014e-05	4.008	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.089881e-04	3.963	0
Regulation of NF-kappa B signaling	R-HSA-9758274	1.340715e-04	3.873	0
Oncogene Induced Senescence	R-HSA-2559585	1.288219e-04	3.890	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.288219e-04	3.890	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.419404e-04	3.848	0
Apoptosis	R-HSA-109581	1.913284e-04	3.718	0
NF-kB is activated and signals survival	R-HSA-209560	1.985592e-04	3.702	0
Separation of Sister Chromatids	R-HSA-2467813	2.232583e-04	3.651	0
Signaling by NOTCH3	R-HSA-9012852	2.236679e-04	3.650	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.380540e-04	3.623	0
ISG15 antiviral mechanism	R-HSA-1169408	2.395026e-04	3.621	0
Apoptotic execution phase	R-HSA-75153	2.303703e-04	3.638	0
Ribosomal scanning and start codon recognition	R-HSA-72702	2.574299e-04	3.589	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.574858e-04	3.589	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.744138e-04	3.562	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.868483e-04	3.542	0
Formation of a pool of free 40S subunits	R-HSA-72689	3.040359e-04	3.517	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.103977e-04	3.508	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.123663e-04	3.505	0
ATP-dependent chromatin remodelers	R-HSA-9932444	3.526411e-04	3.453	0
SWI/SNF chromatin remodelers	R-HSA-9932451	3.526411e-04	3.453	0
Peptide chain elongation	R-HSA-156902	3.615211e-04	3.442	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.842188e-04	3.415	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.716512e-04	3.430	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.804092e-04	3.420	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.929369e-04	3.307	0
Processing of DNA double-strand break ends	R-HSA-5693607	4.748282e-04	3.323	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.173962e-04	3.286	0
Metalloprotease DUBs	R-HSA-5689901	4.338194e-04	3.363	0
Homology Directed Repair	R-HSA-5693538	4.366415e-04	3.360	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.391565e-04	3.357	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.391565e-04	3.357	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.391565e-04	3.357	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.391565e-04	3.357	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.931871e-04	3.307	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.399030e-04	3.357	0
NRIF signals cell death from the nucleus	R-HSA-205043	5.173962e-04	3.286	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.391565e-04	3.357	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.449658e-04	3.264	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.646080e-04	3.248	0
Signaling by FGFR4	R-HSA-5654743	5.841624e-04	3.233	0
MITF-M-regulated melanocyte development	R-HSA-9730414	5.832037e-04	3.234	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.290206e-04	3.201	0
Cyclin D associated events in G1	R-HSA-69231	6.763627e-04	3.170	0
G1 Phase	R-HSA-69236	6.763627e-04	3.170	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.839659e-04	3.165	0
G1/S DNA Damage Checkpoints	R-HSA-69615	6.378417e-04	3.195	0
p75NTR signals via NF-kB	R-HSA-193639	6.839659e-04	3.165	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.375154e-04	3.196	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.375154e-04	3.196	0
G2/M DNA damage checkpoint	R-HSA-69473	6.941187e-04	3.159	0
Host Interactions of HIV factors	R-HSA-162909	7.228938e-04	3.141	0
Signaling by FGFR3	R-HSA-5654741	7.802443e-04	3.108	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.928851e-04	3.101	0
Pexophagy	R-HSA-9664873	8.027836e-04	3.095	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.081707e-04	3.092	0
mRNA Splicing - Major Pathway	R-HSA-72163	8.171421e-04	3.088	0
Regulation of BACH1 activity	R-HSA-9708530	8.892813e-04	3.051	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.969054e-04	3.047	0
Signaling by EGFR	R-HSA-177929	9.237774e-04	3.034	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	9.237774e-04	3.034	0
Signaling by FGFR1	R-HSA-5654736	9.237774e-04	3.034	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.767306e-04	3.010	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.022840e-03	2.990	0
Ribosome-associated quality control	R-HSA-9948299	1.071618e-03	2.970	0
Stabilization of p53	R-HSA-69541	1.097226e-03	2.960	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.097226e-03	2.960	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.097226e-03	2.960	0
Maturation of protein E	R-HSA-9694493	1.039131e-03	2.983	0
Maturation of protein E	R-HSA-9683683	1.039131e-03	2.983	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.112653e-03	2.954	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.139051e-03	2.943	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.270281e-03	2.896	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.335483e-03	2.874	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.441598e-03	2.841	0
Signaling by ERBB2	R-HSA-1227986	1.486151e-03	2.828	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.378250e-03	2.861	0
Epigenetic regulation of gene expression	R-HSA-212165	1.417886e-03	2.848	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.503283e-03	2.823	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.396260e-03	2.855	0
Signaling by ROBO receptors	R-HSA-376176	1.409395e-03	2.851	0
mRNA Splicing	R-HSA-72172	1.582346e-03	2.801	0
Programmed Cell Death	R-HSA-5357801	1.675440e-03	2.776	0
Mitotic Prometaphase	R-HSA-68877	1.676064e-03	2.776	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.731725e-03	2.762	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.780293e-03	2.750	0
Striated Muscle Contraction	R-HSA-390522	1.780293e-03	2.750	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.986448e-03	2.702	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.909762e-03	2.719	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.986448e-03	2.702	0
Switching of origins to a post-replicative state	R-HSA-69052	1.915814e-03	2.718	0
IRAK1 recruits IKK complex	R-HSA-937039	1.986448e-03	2.702	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.986448e-03	2.702	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.925130e-03	2.716	0
p75NTR recruits signalling complexes	R-HSA-209543	1.986448e-03	2.702	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.069762e-03	2.684	0
Dual Incision in GG-NER	R-HSA-5696400	2.070571e-03	2.684	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.070571e-03	2.684	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.070571e-03	2.684	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.216832e-03	2.654	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.293389e-03	2.640	0
Amplification of signal from the kinetochores	R-HSA-141424	2.293389e-03	2.640	0
Eukaryotic Translation Termination	R-HSA-72764	2.401805e-03	2.619	0
Regulation of PTEN localization	R-HSA-8948747	2.330386e-03	2.633	0
Signaling by TGFB family members	R-HSA-9006936	2.200963e-03	2.657	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.442558e-03	2.612	0
Cellular response to hypoxia	R-HSA-1234174	2.554761e-03	2.593	0
Signaling by NOTCH1	R-HSA-1980143	2.566515e-03	2.591	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.574203e-03	2.589	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.574203e-03	2.589	0
MITF-M-dependent gene expression	R-HSA-9856651	2.608533e-03	2.584	0
SARS-CoV-1 Infection	R-HSA-9678108	2.668991e-03	2.574	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.707466e-03	2.567	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.707466e-03	2.567	0
Negative regulation of MET activity	R-HSA-6807004	2.707466e-03	2.567	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.762044e-03	2.559	0
Regulation of TP53 Degradation	R-HSA-6804757	2.762044e-03	2.559	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.779728e-03	2.556	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.825191e-03	2.549	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.825191e-03	2.549	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.052308e-03	2.515	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.092636e-03	2.510	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.270478e-03	2.485	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.886931e-03	2.540	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.270478e-03	2.485	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.169280e-03	2.499	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.270478e-03	2.485	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.270478e-03	2.485	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.960224e-03	2.529	0
Modulation by Mtb of host immune system	R-HSA-9637628	3.270478e-03	2.485	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.275245e-03	2.485	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.275245e-03	2.485	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	3.278760e-03	2.484	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.378280e-03	2.471	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.399626e-03	2.469	0
Nuclear Envelope Breakdown	R-HSA-2980766	3.399626e-03	2.469	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.523298e-03	2.453	0
Cellular response to heat stress	R-HSA-3371556	3.523298e-03	2.453	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.590236e-03	2.445	0
Signaling by FGFR2	R-HSA-5654738	3.702834e-03	2.431	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.742214e-03	2.427	0
Selenocysteine synthesis	R-HSA-2408557	3.883301e-03	2.411	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.112373e-03	2.386	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.927263e-03	2.406	0
Viral mRNA Translation	R-HSA-192823	4.516969e-03	2.345	0
EGFR downregulation	R-HSA-182971	4.549463e-03	2.342	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.440322e-03	2.353	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.509037e-03	2.346	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.509037e-03	2.346	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.448968e-03	2.352	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.112373e-03	2.386	0
HIV Life Cycle	R-HSA-162587	4.016069e-03	2.396	0
Membrane Trafficking	R-HSA-199991	4.519797e-03	2.345	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.122530e-03	2.385	0
Evasion by RSV of host interferon responses	R-HSA-9833109	4.549463e-03	2.342	0
Cell junction organization	R-HSA-446728	4.288552e-03	2.368	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.577824e-03	2.339	0
Regulation of mitotic cell cycle	R-HSA-453276	4.577824e-03	2.339	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.633077e-03	2.334	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.670707e-03	2.331	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.670707e-03	2.331	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.675089e-03	2.330	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.863813e-03	2.313	0
Assembly of the pre-replicative complex	R-HSA-68867	4.880813e-03	2.312	0
Negative regulation of FLT3	R-HSA-9706369	5.087221e-03	2.294	0
HIV Infection	R-HSA-162906	5.274926e-03	2.278	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.480765e-03	2.261	0
Nucleotide Excision Repair	R-HSA-5696398	5.621998e-03	2.250	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.863388e-03	2.232	0
Josephin domain DUBs	R-HSA-5689877	5.863388e-03	2.232	0
Signaling by NOTCH4	R-HSA-9013694	5.982024e-03	2.223	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.003546e-03	2.222	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.003546e-03	2.222	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.003546e-03	2.222	0
Nervous system development	R-HSA-9675108	6.148971e-03	2.211	0
G beta:gamma signalling through CDC42	R-HSA-8964616	6.215302e-03	2.207	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.215302e-03	2.207	0
Orc1 removal from chromatin	R-HSA-68949	6.218822e-03	2.206	0
Cell-Cell communication	R-HSA-1500931	6.399171e-03	2.194	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.460809e-03	2.190	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.854177e-03	2.164	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.422519e-03	2.129	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.518631e-03	2.186	0
Nuclear import of Rev protein	R-HSA-180746	7.779114e-03	2.109	0
Mitophagy	R-HSA-5205647	7.779114e-03	2.109	0
Mitotic Prophase	R-HSA-68875	7.603670e-03	2.119	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.779114e-03	2.109	0
Sema4D in semaphorin signaling	R-HSA-400685	7.521905e-03	2.124	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.561539e-03	2.121	0
Signaling by FGFR	R-HSA-190236	7.640115e-03	2.117	0
Signaling by NOTCH2	R-HSA-1980145	7.779114e-03	2.109	0
Axon guidance	R-HSA-422475	7.975996e-03	2.098	0
p75 NTR receptor-mediated signalling	R-HSA-193704	8.200723e-03	2.086	0
G alpha (12/13) signalling events	R-HSA-416482	8.357118e-03	2.078	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.388482e-03	2.076	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.703221e-03	2.060	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.877876e-03	2.052	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.977661e-03	2.047	0
Chaperone Mediated Autophagy	R-HSA-9613829	8.977661e-03	2.047	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.977661e-03	2.047	0
Signaling by NOTCH	R-HSA-157118	9.496005e-03	2.022	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	9.554838e-03	2.020	0
FLT3 signaling in disease	R-HSA-9682385	9.914968e-03	2.004	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.007864e-02	1.997	0
Regulation of CDH1 Function	R-HSA-9764561	1.012580e-02	1.995	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.027966e-02	1.988	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.027966e-02	1.988	0
Regulation of signaling by CBL	R-HSA-912631	1.063418e-02	1.973	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.063418e-02	1.973	0
S Phase	R-HSA-69242	1.070767e-02	1.970	0
Manipulation of host energy metabolism	R-HSA-9636667	1.186492e-02	1.926	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.345762e-02	1.871	0
SHC-related events triggered by IGF1R	R-HSA-2428933	1.186141e-02	1.926	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.303776e-02	1.885	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.303776e-02	1.885	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.137038e-02	1.944	0
Metabolism of non-coding RNA	R-HSA-194441	1.212093e-02	1.916	0
snRNP Assembly	R-HSA-191859	1.212093e-02	1.916	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.145439e-02	1.941	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.321666e-02	1.879	0
Degradation of AXIN	R-HSA-4641257	1.113003e-02	1.954	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.137038e-02	1.944	0
GPER1 signaling	R-HSA-9634597	1.254413e-02	1.902	0
Mitotic G2-G2/M phases	R-HSA-453274	1.082348e-02	1.966	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.186141e-02	1.926	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.186141e-02	1.926	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.254413e-02	1.902	0
Signaling by LTK	R-HSA-9842663	1.186141e-02	1.926	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.339062e-02	1.873	0
VLDLR internalisation and degradation	R-HSA-8866427	1.186141e-02	1.926	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.141624e-02	1.942	0
Degradation of CDH1	R-HSA-9766229	1.380435e-02	1.860	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.387799e-02	1.858	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.439532e-02	1.842	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.454964e-02	1.837	0
Gene expression (Transcription)	R-HSA-74160	1.475554e-02	1.831	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.476832e-02	1.831	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.476832e-02	1.831	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.476832e-02	1.831	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.476832e-02	1.831	0
Synthesis of DNA	R-HSA-69239	1.482647e-02	1.829	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.542004e-02	1.812	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.542004e-02	1.812	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.542004e-02	1.812	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.564388e-02	1.806	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.587772e-02	1.799	0
SARS-CoV Infections	R-HSA-9679506	1.612238e-02	1.793	0
Cellular response to chemical stress	R-HSA-9711123	1.639918e-02	1.785	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.659780e-02	1.780	0
Activation of NF-kappaB in B cells	R-HSA-1169091	1.659780e-02	1.780	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.665225e-02	1.779	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.665225e-02	1.779	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.665225e-02	1.779	0
Budding and maturation of HIV virion	R-HSA-162588	1.665225e-02	1.779	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.667653e-02	1.778	0
DNA Replication Pre-Initiation	R-HSA-69002	1.673925e-02	1.776	0
Assembly Of The HIV Virion	R-HSA-175474	1.682748e-02	1.774	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.708006e-02	1.768	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.710724e-02	1.767	0
Circadian clock	R-HSA-9909396	1.718796e-02	1.765	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.747660e-02	1.758	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.747660e-02	1.758	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.755169e-02	1.756	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.774623e-02	1.751	0
Cellular response to starvation	R-HSA-9711097	1.782125e-02	1.749	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.813765e-02	1.741	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.869547e-02	1.728	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.886232e-02	1.724	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.886232e-02	1.724	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.886232e-02	1.724	0
Notch-HLH transcription pathway	R-HSA-350054	1.933019e-02	1.714	0
Regulation of TP53 Expression	R-HSA-6804754	2.035775e-02	1.691	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.081109e-02	1.682	0
G beta:gamma signalling through BTK	R-HSA-8964315	2.081109e-02	1.682	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.451054e-02	1.611	0
Translesion synthesis by POLI	R-HSA-5656121	2.451054e-02	1.611	0
Deadenylation of mRNA	R-HSA-429947	2.504017e-02	1.601	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.090355e-02	1.680	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.090355e-02	1.680	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.328178e-02	1.633	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.977721e-02	1.704	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.532483e-02	1.596	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.986614e-02	1.702	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.583505e-02	1.588	0
G-protein beta:gamma signalling	R-HSA-397795	2.090355e-02	1.680	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.081109e-02	1.682	0
Regulation of endogenous retroelements	R-HSA-9842860	2.265903e-02	1.645	0
Translesion synthesis by REV1	R-HSA-110312	2.081109e-02	1.682	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.583505e-02	1.588	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.943351e-02	1.711	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.090355e-02	1.680	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.042045e-02	1.690	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.498293e-02	1.602	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.583505e-02	1.588	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.151960e-02	1.667	0
Vpu mediated degradation of CD4	R-HSA-180534	2.328178e-02	1.633	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.328178e-02	1.633	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	2.583505e-02	1.588	0
TNF signaling	R-HSA-75893	2.532483e-02	1.596	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.544901e-02	1.594	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.081109e-02	1.682	0
Beta-catenin independent WNT signaling	R-HSA-3858494	2.225338e-02	1.653	0
Inositol phosphate metabolism	R-HSA-1483249	1.995204e-02	1.700	0
Glycolysis	R-HSA-70171	2.010147e-02	1.697	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.498293e-02	1.602	0
Smooth Muscle Contraction	R-HSA-445355	1.977721e-02	1.704	0
Response of Mtb to phagocytosis	R-HSA-9637690	2.280989e-02	1.642	0
SARS-CoV-2 Infection	R-HSA-9694516	2.059164e-02	1.686	0
Selenoamino acid metabolism	R-HSA-2408522	2.357380e-02	1.628	0
DNA Replication	R-HSA-69306	2.707930e-02	1.567	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.727811e-02	1.564	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.729363e-02	1.564	0
Activation of G protein gated Potassium channels	R-HSA-1296041	2.826047e-02	1.549	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	2.826047e-02	1.549	0
G protein gated Potassium channels	R-HSA-1296059	2.826047e-02	1.549	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.833239e-02	1.548	0
Death Receptor Signaling	R-HSA-73887	2.833239e-02	1.548	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.834877e-02	1.547	0
Unwinding of DNA	R-HSA-176974	2.834877e-02	1.547	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.834877e-02	1.547	0
Regulated proteolysis of p75NTR	R-HSA-193692	2.834877e-02	1.547	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.856789e-02	1.544	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.856789e-02	1.544	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.856789e-02	1.544	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.856789e-02	1.544	0
Regulation of Apoptosis	R-HSA-169911	2.856789e-02	1.544	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.856789e-02	1.544	0
Translesion synthesis by POLK	R-HSA-5655862	2.858263e-02	1.544	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.858263e-02	1.544	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.863984e-02	1.543	0
Dual incision in TC-NER	R-HSA-6782135	2.957619e-02	1.529	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.974537e-02	1.527	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.067587e-02	1.513	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.070498e-02	1.513	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.113429e-02	1.507	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.148445e-02	1.502	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.173166e-02	1.499	0
Suppression of phagosomal maturation	R-HSA-9637687	3.173166e-02	1.499	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.253586e-02	1.488	0
Regulation of FZD by ubiquitination	R-HSA-4641263	3.303297e-02	1.481	0
Signaling by Hippo	R-HSA-2028269	3.303297e-02	1.481	0
Glycogen storage diseases	R-HSA-3229121	3.303297e-02	1.481	0
G2/M Transition	R-HSA-69275	3.402938e-02	1.468	0
Ovarian tumor domain proteases	R-HSA-5689896	3.458846e-02	1.461	0
Degradation of DVL	R-HSA-4641258	3.458846e-02	1.461	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.458846e-02	1.461	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.458846e-02	1.461	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.466096e-02	1.460	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.504599e-02	1.455	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.545821e-02	1.450	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.545821e-02	1.450	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.545821e-02	1.450	0
Signaling by ERBB4	R-HSA-1236394	3.738390e-02	1.427	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.786520e-02	1.422	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.788324e-02	1.422	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.788324e-02	1.422	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	5.277174e-02	1.278	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	5.277174e-02	1.278	0
G2 Phase	R-HSA-68911	5.610491e-02	1.251	0
Activated NTRK3 signals through RAS	R-HSA-9034864	4.163580e-02	1.381	0
Activated NTRK2 signals through RAS	R-HSA-9026519	4.925857e-02	1.308	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.925857e-02	1.308	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.751039e-02	1.240	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.308108e-02	1.366	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.868052e-02	1.313	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.868052e-02	1.313	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.868052e-02	1.313	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.868052e-02	1.313	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.868052e-02	1.313	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.369119e-02	1.360	0
Late endosomal microautophagy	R-HSA-9615710	4.369119e-02	1.360	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.820244e-02	1.317	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.757780e-02	1.323	0
AURKA Activation by TPX2	R-HSA-8854518	5.142615e-02	1.289	0
PKR-mediated signaling	R-HSA-9833482	5.365445e-02	1.270	0
Translesion Synthesis by POLH	R-HSA-110320	4.308108e-02	1.366	0
G-protein activation	R-HSA-202040	5.466173e-02	1.262	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.268771e-02	1.370	0
Interleukin-1 signaling	R-HSA-9020702	4.507025e-02	1.346	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.925857e-02	1.308	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	5.466173e-02	1.262	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.505625e-02	1.346	0
Integration of provirus	R-HSA-162592	4.925857e-02	1.308	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.925857e-02	1.308	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.893897e-02	1.310	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.109176e-02	1.292	0
G1/S Transition	R-HSA-69206	4.530214e-02	1.344	0
PTEN Regulation	R-HSA-6807070	4.889177e-02	1.311	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.610491e-02	1.251	0
Degradation of CRY and PER proteins	R-HSA-9932298	5.302144e-02	1.276	0
STING mediated induction of host immune responses	R-HSA-1834941	4.308108e-02	1.366	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	4.308108e-02	1.366	0
HATs acetylate histones	R-HSA-3214847	4.057468e-02	1.392	0
Activation of BH3-only proteins	R-HSA-114452	4.820244e-02	1.317	0
DNA Repair	R-HSA-73894	4.461484e-02	1.351	0
TCF dependent signaling in response to WNT	R-HSA-201681	5.301213e-02	1.276	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.302144e-02	1.276	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.949857e-02	1.403	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.744112e-02	1.324	0
Translation	R-HSA-72766	5.304891e-02	1.275	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.297871e-02	1.276	0
Transcriptional Regulation by VENTX	R-HSA-8853884	4.893897e-02	1.310	0
Inwardly rectifying K+ channels	R-HSA-1296065	5.802040e-02	1.236	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.137168e-02	1.383	0
Generic Transcription Pathway	R-HSA-212436	5.495555e-02	1.260	0
Cellular responses to mechanical stimuli	R-HSA-9855142	4.540842e-02	1.343	0
Semaphorin interactions	R-HSA-373755	4.228789e-02	1.374	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	5.610491e-02	1.251	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.466173e-02	1.262	0
Hh mutants are degraded by ERAD	R-HSA-5362768	4.893897e-02	1.310	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.893897e-02	1.310	0
Signaling by MET	R-HSA-6806834	5.365445e-02	1.270	0
Opioid Signalling	R-HSA-111885	5.243410e-02	1.280	0
EPH-Ephrin signaling	R-HSA-2682334	5.475444e-02	1.262	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.466173e-02	1.262	0
Glucose metabolism	R-HSA-70326	5.733032e-02	1.242	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.893897e-02	1.310	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.610491e-02	1.251	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.757780e-02	1.323	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	5.466173e-02	1.262	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	3.944378e-02	1.404	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.369119e-02	1.360	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.802040e-02	1.236	0
FLT3 Signaling	R-HSA-9607240	4.893897e-02	1.310	0
Glycogen synthesis	R-HSA-3322077	4.868052e-02	1.313	0
Translation of Structural Proteins	R-HSA-9683701	5.302144e-02	1.276	0
HDACs deacetylate histones	R-HSA-3214815	5.859916e-02	1.232	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.996443e-02	1.222	0
Signaling by PDGFR in disease	R-HSA-9671555	6.102131e-02	1.215	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.102131e-02	1.215	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.102131e-02	1.215	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	6.178972e-02	1.209	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.327204e-02	1.199	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.327204e-02	1.199	0
Regulation of necroptotic cell death	R-HSA-5675482	6.332712e-02	1.198	0
Regulation of MECP2 expression and activity	R-HSA-9022692	6.332712e-02	1.198	0
Nuclear RNA decay	R-HSA-9930044	6.332712e-02	1.198	0
Adherens junctions interactions	R-HSA-418990	6.459970e-02	1.190	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.545730e-02	1.184	0
Interleukin-17 signaling	R-HSA-448424	6.545730e-02	1.184	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.636900e-02	1.178	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	6.636900e-02	1.178	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.636900e-02	1.178	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	6.636900e-02	1.178	0
Antigen processing-Cross presentation	R-HSA-1236975	6.642215e-02	1.178	0
RMTs methylate histone arginines	R-HSA-3214858	6.647653e-02	1.177	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.775432e-02	1.169	0
mTORC1-mediated signalling	R-HSA-166208	6.775432e-02	1.169	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.872123e-02	1.163	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.889773e-02	1.162	0
Hedgehog 'on' state	R-HSA-5632684	6.930104e-02	1.159	0
Signaling by WNT	R-HSA-195721	6.930685e-02	1.159	0
Oncogenic MAPK signaling	R-HSA-6802957	7.028709e-02	1.153	0
MAPK6/MAPK4 signaling	R-HSA-5687128	7.028709e-02	1.153	0
IkBA variant leads to EDA-ID	R-HSA-5603029	7.077217e-02	1.150	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	7.077217e-02	1.150	0
Noncanonical activation of NOTCH3	R-HSA-9017802	7.077217e-02	1.150	0
RNA Polymerase II Transcription	R-HSA-73857	7.106163e-02	1.148	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.136504e-02	1.147	0
Fanconi Anemia Pathway	R-HSA-6783310	7.136504e-02	1.147	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.136504e-02	1.147	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.136504e-02	1.147	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.136504e-02	1.147	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.395903e-02	1.131	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.419368e-02	1.130	0
RAF activation	R-HSA-5673000	7.473036e-02	1.127	0
Calnexin/calreticulin cycle	R-HSA-901042	7.473036e-02	1.127	0
NOD1/2 Signaling Pathway	R-HSA-168638	7.473036e-02	1.127	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.485444e-02	1.126	0
Deadenylation-dependent mRNA decay	R-HSA-429914	7.555417e-02	1.122	0
Diseases of DNA repair	R-HSA-9675135	7.645470e-02	1.117	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.645470e-02	1.117	0
Ca2+ pathway	R-HSA-4086398	7.739500e-02	1.111	0
Deubiquitination	R-HSA-5688426	7.743791e-02	1.111	0
Regulation of PTEN gene transcription	R-HSA-8943724	8.019863e-02	1.096	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.100724e-02	1.091	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.227596e-02	1.085	0
Thromboxane signalling through TP receptor	R-HSA-428930	8.231405e-02	1.085	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.231405e-02	1.085	0
Viral Messenger RNA Synthesis	R-HSA-168325	8.500481e-02	1.071	0
MAP kinase activation	R-HSA-450294	8.500481e-02	1.071	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.580374e-02	1.066	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.580374e-02	1.066	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.580374e-02	1.066	0
Autointegration results in viral DNA circles	R-HSA-177539	8.652052e-02	1.063	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.652052e-02	1.063	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	8.652052e-02	1.063	0
ER-Phagosome pathway	R-HSA-1236974	8.980904e-02	1.047	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.012435e-02	1.045	0
HDMs demethylate histones	R-HSA-3214842	9.012435e-02	1.045	0
UCH proteinases	R-HSA-5689603	9.055231e-02	1.043	0
Viral Infection Pathways	R-HSA-9824446	9.075351e-02	1.042	0
DNA Damage Bypass	R-HSA-73893	9.291855e-02	1.032	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	9.509912e-02	1.022	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	9.509912e-02	1.022	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	9.509912e-02	1.022	0
Signaling by PTK6	R-HSA-8848021	9.509912e-02	1.022	0
Translation of Structural Proteins	R-HSA-9694635	9.520790e-02	1.021	0
Phosphorylation of the APC/C	R-HSA-176412	9.632325e-02	1.016	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	9.632325e-02	1.016	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	9.632325e-02	1.016	0
Autophagy	R-HSA-9612973	9.662355e-02	1.015	0
rRNA processing	R-HSA-72312	9.780251e-02	1.010	0
Hereditary fructose intolerance	R-HSA-5657560	1.027617e-01	0.988	0
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.027617e-01	0.988	0
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.027617e-01	0.988	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.027617e-01	0.988	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.027617e-01	0.988	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	1.501162e-01	0.824	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	1.501162e-01	0.824	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	1.501162e-01	0.824	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	1.501162e-01	0.824	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	1.501162e-01	0.824	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.501162e-01	0.824	0
IKBKB deficiency causes SCID	R-HSA-5602636	1.501162e-01	0.824	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.949742e-01	0.710	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.949742e-01	0.710	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.949742e-01	0.710	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.949742e-01	0.710	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	1.949742e-01	0.710	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.031953e-01	0.986	0
Type I hemidesmosome assembly	R-HSA-446107	1.206551e-01	0.918	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.206551e-01	0.918	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.206551e-01	0.918	0
ALK mutants bind TKIs	R-HSA-9700645	1.387710e-01	0.858	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.574251e-01	0.803	0
Folding of actin by CCT/TriC	R-HSA-390450	1.574251e-01	0.803	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.073372e-01	0.969	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.765105e-01	0.753	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.765105e-01	0.753	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.765105e-01	0.753	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.959299e-01	0.708	0
Proton-coupled monocarboxylate transport	R-HSA-433692	1.959299e-01	0.708	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.959299e-01	0.708	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.959299e-01	0.708	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.307211e-01	0.884	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.686992e-01	0.773	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.340588e-01	0.873	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.820021e-01	0.740	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	1.820021e-01	0.740	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.820021e-01	0.740	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.077110e-01	0.968	0
mRNA 3'-end processing	R-HSA-72187	1.111333e-01	0.954	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.383846e-01	0.859	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.724145e-01	0.763	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.724145e-01	0.763	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.724145e-01	0.763	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.724145e-01	0.763	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.524789e-01	0.817	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.353335e-01	0.869	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.547783e-01	0.810	0
Protein ubiquitination	R-HSA-8852135	1.684162e-01	0.774	0
Centrosome maturation	R-HSA-380287	1.684162e-01	0.774	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.611467e-01	0.793	0
Chaperonin-mediated protein folding	R-HSA-390466	1.549788e-01	0.810	0
Ub-specific processing proteases	R-HSA-5689880	1.052006e-01	0.978	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.738182e-01	0.760	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.481583e-01	0.829	0
Signaling by RAF1 mutants	R-HSA-9656223	1.303830e-01	0.885	0
G0 and Early G1	R-HSA-1538133	1.536771e-01	0.813	0
Regulation of CDH11 function	R-HSA-9762292	1.574251e-01	0.803	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.955733e-01	0.709	0
Signaling by RAS mutants	R-HSA-6802949	1.724145e-01	0.763	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.031953e-01	0.986	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	1.206551e-01	0.918	0
HSF1-dependent transactivation	R-HSA-3371571	1.048714e-01	0.979	0
Signal attenuation	R-HSA-74749	1.574251e-01	0.803	0
Selective autophagy	R-HSA-9663891	1.611467e-01	0.793	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	1.959299e-01	0.708	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.827546e-02	1.008	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.246610e-01	0.904	0
Adipogenesis	R-HSA-9843745	1.087343e-01	0.964	0
Protein folding	R-HSA-391251	1.936230e-01	0.713	0
Signal amplification	R-HSA-392518	1.849435e-01	0.733	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.614812e-01	0.792	0
Resolution of D-Loop Structures	R-HSA-5693537	1.742960e-01	0.759	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.765105e-01	0.753	0
Polo-like kinase mediated events	R-HSA-156711	1.307211e-01	0.884	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.111333e-01	0.954	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.067565e-01	0.972	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.638689e-01	0.786	0
Macroautophagy	R-HSA-1632852	1.559536e-01	0.807	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.150394e-01	0.939	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.150394e-01	0.939	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.387710e-01	0.858	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.318023e-01	0.880	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.073372e-01	0.969	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.318023e-01	0.880	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.314843e-01	0.881	0
Interleukin-1 family signaling	R-HSA-446652	1.393746e-01	0.856	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.087710e-01	0.963	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.481583e-01	0.829	0
Inhibition of PKR	R-HSA-169131	1.027617e-01	0.988	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	1.501162e-01	0.824	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	1.501162e-01	0.824	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	1.501162e-01	0.824	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	1.949742e-01	0.710	0
Interleukin-33 signaling	R-HSA-9014843	1.949742e-01	0.710	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.387710e-01	0.858	0
Signaling by APC mutants	R-HSA-4839744	1.765105e-01	0.753	0
Signaling by AXIN mutants	R-HSA-4839735	1.959299e-01	0.708	0
Signaling by AMER1 mutants	R-HSA-4839748	1.959299e-01	0.708	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.820021e-01	0.740	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.753799e-01	0.756	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.450177e-01	0.839	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.428255e-01	0.845	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.428255e-01	0.845	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.428255e-01	0.845	0
Interferon Signaling	R-HSA-913531	1.152908e-01	0.938	0
Regulation of PTEN stability and activity	R-HSA-8948751	1.175814e-01	0.930	0
Heme signaling	R-HSA-9707616	1.833099e-01	0.737	0
Signalling to ERKs	R-HSA-187687	1.957959e-01	0.708	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.188139e-01	0.925	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.820021e-01	0.740	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.099742e-01	0.959	0
PKMTs methylate histone lysines	R-HSA-3214841	1.225990e-01	0.912	0
Vesicle-mediated transport	R-HSA-5653656	1.248592e-01	0.904	0
Regulation of RAS by GAPs	R-HSA-5658442	9.879885e-02	1.005	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.481583e-01	0.829	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.188139e-01	0.925	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.188139e-01	0.925	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	1.340588e-01	0.873	0
Activation of GABAB receptors	R-HSA-991365	1.383846e-01	0.859	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.913788e-01	0.718	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.272768e-01	0.895	0
Breakdown of the nuclear lamina	R-HSA-352238	1.501162e-01	0.824	0
DSCAM interactions	R-HSA-376172	1.949742e-01	0.710	0
Diseases of cellular response to stress	R-HSA-9675132	1.949742e-01	0.710	0
Diseases of Cellular Senescence	R-HSA-9630747	1.949742e-01	0.710	0
TGFBR3 PTM regulation	R-HSA-9839383	1.206551e-01	0.918	0
SLC-mediated bile acid transport	R-HSA-9958517	1.206551e-01	0.918	0
ARMS-mediated activation	R-HSA-170984	1.387710e-01	0.858	0
2-LTR circle formation	R-HSA-164843	1.574251e-01	0.803	0
Disorders of Developmental Biology	R-HSA-9675151	1.073372e-01	0.969	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.959299e-01	0.708	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.686992e-01	0.773	0
GABA B receptor activation	R-HSA-977444	1.383846e-01	0.859	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.002533e-01	0.999	0
Cell-cell junction organization	R-HSA-421270	1.575918e-01	0.802	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.006198e-01	0.997	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.436092e-01	0.843	0
Signaling by TGFBR3	R-HSA-9839373	1.724145e-01	0.763	0
Downstream signaling of activated FGFR1	R-HSA-5654687	1.957959e-01	0.708	0
Downstream TCR signaling	R-HSA-202424	1.738182e-01	0.760	0
Aquaporin-mediated transport	R-HSA-445717	1.753799e-01	0.756	0
EPHB-mediated forward signaling	R-HSA-3928662	1.550108e-01	0.810	0
RSV-host interactions	R-HSA-9833110	1.832672e-01	0.737	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.686992e-01	0.773	0
MECP2 regulates transcription factors	R-HSA-9022707	1.031953e-01	0.986	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.067565e-01	0.972	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.820021e-01	0.740	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.416757e-01	0.849	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.067565e-01	0.972	0
Gluconeogenesis	R-HSA-70263	1.905284e-01	0.720	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.067565e-01	0.972	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.820021e-01	0.740	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.387710e-01	0.858	0
Basigin interactions	R-HSA-210991	1.686992e-01	0.773	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.003850e-01	0.998	0
Regulation of pyruvate metabolism	R-HSA-9861718	1.724145e-01	0.763	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.380053e-01	0.860	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.636196e-01	0.786	0
ABC transporter disorders	R-HSA-5619084	1.898133e-01	0.722	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.383846e-01	0.859	0
Glucagon signaling in metabolic regulation	R-HSA-163359	1.742960e-01	0.759	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	1.849435e-01	0.733	0
tRNA processing in the nucleus	R-HSA-6784531	1.833099e-01	0.737	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.803163e-01	0.744	0
Hedgehog ligand biogenesis	R-HSA-5358346	1.048714e-01	0.979	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.387710e-01	0.858	0
Glucagon-type ligand receptors	R-HSA-420092	1.246610e-01	0.904	0
PCP/CE pathway	R-HSA-4086400	1.898133e-01	0.722	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	1.936230e-01	0.713	0
Plasma lipoprotein clearance	R-HSA-8964043	1.077110e-01	0.968	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.998296e-01	0.699	0
Gene Silencing by RNA	R-HSA-211000	2.020098e-01	0.695	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.046584e-01	0.689	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.084286e-01	0.681	0
Interleukin receptor SHC signaling	R-HSA-912526	2.093816e-01	0.679	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.093816e-01	0.679	0
Amyloid fiber formation	R-HSA-977225	2.122425e-01	0.673	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.143128e-01	0.669	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.149289e-01	0.668	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.155949e-01	0.666	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.155949e-01	0.666	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.155949e-01	0.666	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.155949e-01	0.666	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.155949e-01	0.666	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.155949e-01	0.666	0
MET activates RAS signaling	R-HSA-8851805	2.155949e-01	0.666	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.155949e-01	0.666	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.155949e-01	0.666	0
Interleukin-15 signaling	R-HSA-8983432	2.155949e-01	0.666	0
Disorders of Nervous System Development	R-HSA-9697154	2.155949e-01	0.666	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.155949e-01	0.666	0
Pervasive developmental disorders	R-HSA-9005895	2.155949e-01	0.666	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.163590e-01	0.665	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	2.163590e-01	0.665	0
Meiotic recombination	R-HSA-912446	2.188753e-01	0.660	0
Protein localization	R-HSA-9609507	2.230469e-01	0.652	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.233965e-01	0.651	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	2.233965e-01	0.651	0
Neurodegenerative Diseases	R-HSA-8863678	2.233965e-01	0.651	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.233965e-01	0.651	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.233965e-01	0.651	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.285545e-01	0.641	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.294299e-01	0.639	0
Regulated Necrosis	R-HSA-5218859	2.335960e-01	0.632	0
Frs2-mediated activation	R-HSA-170968	2.354257e-01	0.628	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.354257e-01	0.628	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.354257e-01	0.628	0
ESR-mediated signaling	R-HSA-8939211	2.368680e-01	0.625	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.374671e-01	0.624	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.374671e-01	0.624	0
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	2.374671e-01	0.624	0
Defective ABCC2 causes DJS	R-HSA-5679001	2.374671e-01	0.624	0
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	2.374671e-01	0.624	0
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	2.374671e-01	0.624	0
Inhibition of nitric oxide production	R-HSA-9636249	2.374671e-01	0.624	0
STAT6-mediated induction of chemokines	R-HSA-3249367	2.374671e-01	0.624	0
MET interacts with TNS proteins	R-HSA-8875513	2.374671e-01	0.624	0
TGFBR3 expression	R-HSA-9839394	2.375884e-01	0.624	0
Long-term potentiation	R-HSA-9620244	2.375884e-01	0.624	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.384501e-01	0.623	0
Developmental Biology	R-HSA-1266738	2.388352e-01	0.622	0
RAS processing	R-HSA-9648002	2.409490e-01	0.618	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.416913e-01	0.617	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.515996e-01	0.599	0
Myogenesis	R-HSA-525793	2.519286e-01	0.599	0
Aggrephagy	R-HSA-9646399	2.525967e-01	0.598	0
Glycogen metabolism	R-HSA-8982491	2.525967e-01	0.598	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.553501e-01	0.593	0
Zinc transporters	R-HSA-435354	2.553501e-01	0.593	0
Regulation of KIT signaling	R-HSA-1433559	2.553501e-01	0.593	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.624848e-01	0.581	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.643580e-01	0.578	0
Extra-nuclear estrogen signaling	R-HSA-9009391	2.655264e-01	0.576	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	2.663893e-01	0.574	0
NRAGE signals death through JNK	R-HSA-193648	2.686410e-01	0.571	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.686410e-01	0.571	0
Interferon alpha/beta signaling	R-HSA-909733	2.695381e-01	0.569	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.695381e-01	0.569	0
DCC mediated attractive signaling	R-HSA-418885	2.753031e-01	0.560	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.753031e-01	0.560	0
SHC1 events in EGFR signaling	R-HSA-180336	2.753031e-01	0.560	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.753031e-01	0.560	0
Erythropoietin activates RAS	R-HSA-9027284	2.753031e-01	0.560	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.753031e-01	0.560	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.753031e-01	0.560	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.753031e-01	0.560	0
HCN channels	R-HSA-1296061	2.777194e-01	0.556	0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.777194e-01	0.556	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.777194e-01	0.556	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.777194e-01	0.556	0
Nucleotide catabolism defects	R-HSA-9735786	2.777194e-01	0.556	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.777194e-01	0.556	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.777194e-01	0.556	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.777194e-01	0.556	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	2.777194e-01	0.556	0
Sensory perception of sour taste	R-HSA-9729555	2.777194e-01	0.556	0
Diseases of carbohydrate metabolism	R-HSA-5663084	2.783610e-01	0.555	0
Muscle contraction	R-HSA-397014	2.815210e-01	0.550	0
Rab regulation of trafficking	R-HSA-9007101	2.838101e-01	0.547	0
MTOR signalling	R-HSA-165159	2.881631e-01	0.540	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.881631e-01	0.540	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.892115e-01	0.539	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.933281e-01	0.533	0
Signaling by NTRKs	R-HSA-166520	2.933281e-01	0.533	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	2.952263e-01	0.530	0
Prolonged ERK activation events	R-HSA-169893	2.952263e-01	0.530	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.952263e-01	0.530	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.955671e-01	0.529	0
DARPP-32 events	R-HSA-180024	2.955671e-01	0.529	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.955671e-01	0.529	0
Downstream signaling of activated FGFR3	R-HSA-5654708	2.955671e-01	0.529	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	2.968003e-01	0.528	0
Iron uptake and transport	R-HSA-917937	2.968003e-01	0.528	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.982826e-01	0.525	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.982826e-01	0.525	0
Transcriptional regulation by RUNX2	R-HSA-8878166	2.982826e-01	0.525	0
Peroxisomal protein import	R-HSA-9033241	2.996021e-01	0.523	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.013714e-01	0.521	0
Co-inhibition by PD-1	R-HSA-389948	3.042955e-01	0.517	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.061084e-01	0.514	0
GABA receptor activation	R-HSA-977443	3.100508e-01	0.509	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.102342e-01	0.508	0
Activation of the pre-replicative complex	R-HSA-68962	3.102342e-01	0.508	0
Downstream signaling of activated FGFR4	R-HSA-5654716	3.102342e-01	0.508	0
Netrin-1 signaling	R-HSA-373752	3.122498e-01	0.505	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.150673e-01	0.502	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.150673e-01	0.502	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.150673e-01	0.502	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.150673e-01	0.502	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.150673e-01	0.502	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.150673e-01	0.502	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.150673e-01	0.502	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.158493e-01	0.501	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.158493e-01	0.501	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.158493e-01	0.501	0
Reelin signalling pathway	R-HSA-8866376	3.158493e-01	0.501	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.158493e-01	0.501	0
Interleukin-36 pathway	R-HSA-9014826	3.158493e-01	0.501	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.158493e-01	0.501	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	3.158493e-01	0.501	0
Nectin/Necl trans heterodimerization	R-HSA-420597	3.158493e-01	0.501	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	3.158493e-01	0.501	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.203141e-01	0.494	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.203141e-01	0.494	0
Intracellular signaling by second messengers	R-HSA-9006925	3.236301e-01	0.490	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.243644e-01	0.489	0
RNA Polymerase I Transcription	R-HSA-73864	3.248696e-01	0.488	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.249221e-01	0.488	0
Molecules associated with elastic fibres	R-HSA-2129379	3.249221e-01	0.488	0
Trafficking of AMPA receptors	R-HSA-399719	3.249221e-01	0.488	0
tRNA processing	R-HSA-72306	3.310398e-01	0.480	0
Mitochondrial protein import	R-HSA-1268020	3.310868e-01	0.480	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.310868e-01	0.480	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.347792e-01	0.475	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.347792e-01	0.475	0
Specification of primordial germ cells	R-HSA-9827857	3.347792e-01	0.475	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.396087e-01	0.469	0
DNA strand elongation	R-HSA-69190	3.396087e-01	0.469	0
TCR signaling	R-HSA-202403	3.437698e-01	0.464	0
Signaling by VEGF	R-HSA-194138	3.501634e-01	0.456	0
PIP3 activates AKT signaling	R-HSA-1257604	3.512426e-01	0.454	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.519684e-01	0.453	0
Pentose phosphate pathway disease	R-HSA-6791465	3.519684e-01	0.453	0
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	3.519684e-01	0.453	0
Phosphorylation of Emi1	R-HSA-176417	3.519684e-01	0.453	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.519684e-01	0.453	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.519684e-01	0.453	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.519684e-01	0.453	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.519684e-01	0.453	0
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	3.519684e-01	0.453	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.519684e-01	0.453	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.519684e-01	0.453	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.519684e-01	0.453	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.519684e-01	0.453	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.542730e-01	0.451	0
Activation of ATR in response to replication stress	R-HSA-176187	3.542730e-01	0.451	0
Cardiogenesis	R-HSA-9733709	3.542730e-01	0.451	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.542730e-01	0.451	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.542730e-01	0.451	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.542730e-01	0.451	0
Tie2 Signaling	R-HSA-210993	3.543206e-01	0.451	0
Nephron development	R-HSA-9831926	3.543206e-01	0.451	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.543206e-01	0.451	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.608370e-01	0.443	0
NGF-stimulated transcription	R-HSA-9031628	3.608370e-01	0.443	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.616370e-01	0.442	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.616370e-01	0.442	0
Potassium Channels	R-HSA-1296071	3.616370e-01	0.442	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.688952e-01	0.433	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.688952e-01	0.433	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	3.723264e-01	0.429	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.727992e-01	0.429	0
Germ layer formation at gastrulation	R-HSA-9754189	3.736546e-01	0.428	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.736546e-01	0.428	0
Specification of the neural plate border	R-HSA-9834899	3.736546e-01	0.428	0
Rap1 signalling	R-HSA-392517	3.736546e-01	0.428	0
The NLRP3 inflammasome	R-HSA-844456	3.736546e-01	0.428	0
Maturation of nucleoprotein	R-HSA-9694631	3.736546e-01	0.428	0
Disorders of transmembrane transporters	R-HSA-5619115	3.778496e-01	0.423	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.861827e-01	0.413	0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	3.861827e-01	0.413	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	3.861827e-01	0.413	0
Hydrolysis of LPE	R-HSA-1483152	3.861827e-01	0.413	0
NADPH regeneration	R-HSA-389542	3.861827e-01	0.413	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.861827e-01	0.413	0
CREB3 factors activate genes	R-HSA-8874211	3.861827e-01	0.413	0
Meiosis	R-HSA-1500620	3.914040e-01	0.407	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.922097e-01	0.406	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.927485e-01	0.406	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	3.927485e-01	0.406	0
Signal transduction by L1	R-HSA-445144	3.927485e-01	0.406	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.946925e-01	0.404	0
Hedgehog 'off' state	R-HSA-5610787	3.965492e-01	0.402	0
ABC-family proteins mediated transport	R-HSA-382556	3.965492e-01	0.402	0
Downstream signaling of activated FGFR2	R-HSA-5654696	3.979403e-01	0.400	0
Signalling to RAS	R-HSA-167044	4.115740e-01	0.386	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.115740e-01	0.386	0
RAF/MAP kinase cascade	R-HSA-5673001	4.118752e-01	0.385	0
G1/S-Specific Transcription	R-HSA-69205	4.123293e-01	0.385	0
PRC2 methylates histones and DNA	R-HSA-212300	4.123293e-01	0.385	0
HSF1 activation	R-HSA-3371511	4.123293e-01	0.385	0
Calmodulin induced events	R-HSA-111933	4.123293e-01	0.385	0
CaM pathway	R-HSA-111997	4.123293e-01	0.385	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.185925e-01	0.378	0
Netrin mediated repulsion signals	R-HSA-418886	4.185925e-01	0.378	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.185925e-01	0.378	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	4.185925e-01	0.378	0
SOS-mediated signalling	R-HSA-112412	4.185925e-01	0.378	0
Cohesin Loading onto Chromatin	R-HSA-2470946	4.185925e-01	0.378	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.185925e-01	0.378	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	4.185925e-01	0.378	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.185925e-01	0.378	0
RUNX3 regulates WNT signaling	R-HSA-8951430	4.185925e-01	0.378	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.185925e-01	0.378	0
Ca2+ activated K+ channels	R-HSA-1296052	4.185925e-01	0.378	0
Cation-coupled Chloride cotransporters	R-HSA-426117	4.185925e-01	0.378	0
CHL1 interactions	R-HSA-447041	4.185925e-01	0.378	0
Pyruvate metabolism	R-HSA-70268	4.199793e-01	0.377	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.266086e-01	0.370	0
Potential therapeutics for SARS	R-HSA-9679191	4.268744e-01	0.370	0
Regulation of T cell activation by CD28 family	R-HSA-388841	4.280773e-01	0.368	0
Ribavirin ADME	R-HSA-9755088	4.301062e-01	0.366	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.301062e-01	0.366	0
MAPK family signaling cascades	R-HSA-5683057	4.315902e-01	0.365	0
Neddylation	R-HSA-8951664	4.342034e-01	0.362	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.368809e-01	0.360	0
Elastic fibre formation	R-HSA-1566948	4.407640e-01	0.356	0
G alpha (z) signalling events	R-HSA-418597	4.451952e-01	0.351	0
FGFR2 alternative splicing	R-HSA-6803529	4.483236e-01	0.348	0
Estrogen-dependent gene expression	R-HSA-9018519	4.487058e-01	0.348	0
MAPK1/MAPK3 signaling	R-HSA-5684996	4.487560e-01	0.348	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.492930e-01	0.347	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.492930e-01	0.347	0
Formation of annular gap junctions	R-HSA-196025	4.492930e-01	0.347	0
Signaling by ALK	R-HSA-201556	4.547823e-01	0.342	0
Signal Transduction	R-HSA-162582	4.551082e-01	0.342	1
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.562627e-01	0.341	0
Platelet homeostasis	R-HSA-418346	4.574574e-01	0.340	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.577399e-01	0.339	0
Cilium Assembly	R-HSA-5617833	4.603936e-01	0.337	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	4.662077e-01	0.331	0
Syndecan interactions	R-HSA-3000170	4.662077e-01	0.331	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.662077e-01	0.331	0
Toll-like Receptor Cascades	R-HSA-168898	4.668719e-01	0.331	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.686514e-01	0.329	0
Attenuation phase	R-HSA-3371568	4.686514e-01	0.329	0
Interleukin-2 family signaling	R-HSA-451927	4.686514e-01	0.329	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.686514e-01	0.329	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.746588e-01	0.324	0
Gap junction degradation	R-HSA-190873	4.783741e-01	0.320	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.783741e-01	0.320	0
GP1b-IX-V activation signalling	R-HSA-430116	4.783741e-01	0.320	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.783741e-01	0.320	0
WNT mediated activation of DVL	R-HSA-201688	4.783741e-01	0.320	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.783741e-01	0.320	0
Interleukin-1 processing	R-HSA-448706	4.783741e-01	0.320	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.783741e-01	0.320	0
Cellular response to mitochondrial stress	R-HSA-9840373	4.783741e-01	0.320	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.786037e-01	0.320	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.823602e-01	0.317	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.837431e-01	0.315	0
TRAF6 mediated NF-kB activation	R-HSA-933542	4.837431e-01	0.315	0
Complex III assembly	R-HSA-9865881	4.837431e-01	0.315	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.837431e-01	0.315	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.839587e-01	0.315	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.885945e-01	0.311	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.888621e-01	0.311	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.888621e-01	0.311	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.888621e-01	0.311	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.958984e-01	0.305	0
HIV Transcription Initiation	R-HSA-167161	4.958984e-01	0.305	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.958984e-01	0.305	0
MAP2K and MAPK activation	R-HSA-5674135	4.958984e-01	0.305	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	4.958984e-01	0.305	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.958984e-01	0.305	0
SLC-mediated transport of organic anions	R-HSA-9955298	4.987413e-01	0.302	0
HCMV Early Events	R-HSA-9609690	4.990571e-01	0.302	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	5.009167e-01	0.300	0
Acyl chain remodelling of PS	R-HSA-1482801	5.009167e-01	0.300	0
Laminin interactions	R-HSA-3000157	5.009167e-01	0.300	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.009167e-01	0.300	0
RAB geranylgeranylation	R-HSA-8873719	5.033332e-01	0.298	0
Kinesins	R-HSA-983189	5.033332e-01	0.298	0
Platelet degranulation	R-HSA-114608	5.046434e-01	0.297	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.059211e-01	0.296	0
EGFR Transactivation by Gastrin	R-HSA-2179392	5.059211e-01	0.296	0
Receptor Mediated Mitophagy	R-HSA-8934903	5.059211e-01	0.296	0
Regulation of the apoptosome activity	R-HSA-9627069	5.059211e-01	0.296	0
Interleukin-27 signaling	R-HSA-9020956	5.059211e-01	0.296	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.059211e-01	0.296	0
Maturation of spike protein	R-HSA-9683686	5.059211e-01	0.296	0
Formation of apoptosome	R-HSA-111458	5.059211e-01	0.296	0
Sensory processing of sound	R-HSA-9659379	5.088105e-01	0.293	0
Signaling by Nuclear Receptors	R-HSA-9006931	5.092406e-01	0.293	0
Cytosolic tRNA aminoacylation	R-HSA-379716	5.092568e-01	0.293	0
Ca-dependent events	R-HSA-111996	5.092568e-01	0.293	0
PLC beta mediated events	R-HSA-112043	5.146444e-01	0.288	0
Formation of paraxial mesoderm	R-HSA-9793380	5.146444e-01	0.288	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.169777e-01	0.287	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.177177e-01	0.286	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.177177e-01	0.286	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	5.177177e-01	0.286	0
COPI-mediated anterograde transport	R-HSA-6807878	5.222673e-01	0.282	0
RNA Polymerase II Promoter Escape	R-HSA-73776	5.224270e-01	0.282	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.286972e-01	0.277	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.320150e-01	0.274	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	5.320150e-01	0.274	0
Dissolution of Fibrin Clot	R-HSA-75205	5.320150e-01	0.274	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	5.320150e-01	0.274	0
vRNA Synthesis	R-HSA-192814	5.320150e-01	0.274	0
vRNP Assembly	R-HSA-192905	5.320150e-01	0.274	0
Synthesis of PI	R-HSA-1483226	5.320150e-01	0.274	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.320150e-01	0.274	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.320150e-01	0.274	0
PECAM1 interactions	R-HSA-210990	5.320150e-01	0.274	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.320150e-01	0.274	0
Interleukin-2 signaling	R-HSA-9020558	5.320150e-01	0.274	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.341378e-01	0.272	0
Cristae formation	R-HSA-8949613	5.341378e-01	0.272	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.341378e-01	0.272	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.341378e-01	0.272	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.341378e-01	0.272	0
Reproduction	R-HSA-1474165	5.357248e-01	0.271	0
Regulation of insulin secretion	R-HSA-422356	5.401428e-01	0.267	0
IGF1R signaling cascade	R-HSA-2428924	5.478326e-01	0.261	0
Ion transport by P-type ATPases	R-HSA-936837	5.478326e-01	0.261	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.481731e-01	0.261	0
DAG and IP3 signaling	R-HSA-1489509	5.481731e-01	0.261	0
Cytoprotection by HMOX1	R-HSA-9707564	5.482192e-01	0.261	0
FOXO-mediated transcription	R-HSA-9614085	5.489713e-01	0.260	0
HIV elongation arrest and recovery	R-HSA-167287	5.501702e-01	0.260	0
Pausing and recovery of HIV elongation	R-HSA-167290	5.501702e-01	0.260	0
Phase 0 - rapid depolarisation	R-HSA-5576892	5.501702e-01	0.260	0
Pyrimidine salvage	R-HSA-73614	5.501702e-01	0.260	0
Inflammasomes	R-HSA-622312	5.501702e-01	0.260	0
Golgi-to-ER retrograde transport	R-HSA-8856688	5.509863e-01	0.259	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.567323e-01	0.254	0
Activation of RAC1	R-HSA-428540	5.567323e-01	0.254	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.567323e-01	0.254	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.567323e-01	0.254	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.585395e-01	0.253	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.586294e-01	0.253	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.586294e-01	0.253	0
Signaling by Erythropoietin	R-HSA-9006335	5.658101e-01	0.247	0
Mitochondrial biogenesis	R-HSA-1592230	5.660301e-01	0.247	0
Protein-protein interactions at synapses	R-HSA-6794362	5.673451e-01	0.246	0
Synthesis of PC	R-HSA-1483191	5.730856e-01	0.242	0
PI Metabolism	R-HSA-1483255	5.749836e-01	0.240	0
G-protein mediated events	R-HSA-112040	5.797971e-01	0.237	0
GRB2 events in EGFR signaling	R-HSA-179812	5.801456e-01	0.236	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.801456e-01	0.236	0
Repression of WNT target genes	R-HSA-4641265	5.801456e-01	0.236	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.801456e-01	0.236	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.801456e-01	0.236	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.801456e-01	0.236	0
Regulation of IFNG signaling	R-HSA-877312	5.801456e-01	0.236	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.801456e-01	0.236	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.801456e-01	0.236	0
Interleukin-35 Signalling	R-HSA-8984722	5.801456e-01	0.236	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	5.801456e-01	0.236	0
DAP12 signaling	R-HSA-2424491	5.810543e-01	0.236	0
Interleukin-37 signaling	R-HSA-9008059	5.810543e-01	0.236	0
Transcription of the HIV genome	R-HSA-167172	5.901602e-01	0.229	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.901602e-01	0.229	0
Interleukin-12 family signaling	R-HSA-447115	5.952320e-01	0.225	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	5.974219e-01	0.224	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.023235e-01	0.220	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.023235e-01	0.220	0
Processing of SMDT1	R-HSA-8949664	6.023235e-01	0.220	0
Formation of axial mesoderm	R-HSA-9796292	6.023235e-01	0.220	0
Diseases of nucleotide metabolism	R-HSA-9735804	6.023235e-01	0.220	0
Platelet Adhesion to exposed collagen	R-HSA-75892	6.023235e-01	0.220	0
Maturation of nucleoprotein	R-HSA-9683610	6.023235e-01	0.220	0
Interleukin-6 signaling	R-HSA-1059683	6.023235e-01	0.220	0
Signaling by Hedgehog	R-HSA-5358351	6.026489e-01	0.220	0
HCMV Infection	R-HSA-9609646	6.027203e-01	0.220	0
Diseases of programmed cell death	R-HSA-9645723	6.043020e-01	0.219	0
Signaling by WNT in cancer	R-HSA-4791275	6.103493e-01	0.214	0
COPII-mediated vesicle transport	R-HSA-204005	6.104283e-01	0.214	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.104283e-01	0.214	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.233311e-01	0.205	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.233311e-01	0.205	0
CRMPs in Sema3A signaling	R-HSA-399956	6.233311e-01	0.205	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.233311e-01	0.205	0
Retrograde neurotrophin signalling	R-HSA-177504	6.233311e-01	0.205	0
cGMP effects	R-HSA-418457	6.233311e-01	0.205	0
Signal regulatory protein family interactions	R-HSA-391160	6.233311e-01	0.205	0
Hydrolysis of LPC	R-HSA-1483115	6.233311e-01	0.205	0
Physiological factors	R-HSA-5578768	6.233311e-01	0.205	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.233311e-01	0.205	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.244003e-01	0.205	0
Integrin signaling	R-HSA-354192	6.244003e-01	0.205	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.244003e-01	0.205	0
Platelet activation, signaling and aggregation	R-HSA-76002	6.284328e-01	0.202	0
Formation of RNA Pol II elongation complex	R-HSA-112382	6.314868e-01	0.200	0
Neurexins and neuroligins	R-HSA-6794361	6.314868e-01	0.200	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.314868e-01	0.200	0
Stimuli-sensing channels	R-HSA-2672351	6.325936e-01	0.199	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.380554e-01	0.195	0
Miscellaneous transport and binding events	R-HSA-5223345	6.380554e-01	0.195	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.424789e-01	0.192	0
Amino acids regulate mTORC1	R-HSA-9639288	6.424789e-01	0.192	0
Meiotic synapsis	R-HSA-1221632	6.424789e-01	0.192	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.432303e-01	0.192	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.432303e-01	0.192	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.432303e-01	0.192	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.432303e-01	0.192	0
Protein repair	R-HSA-5676934	6.432303e-01	0.192	0
Protein methylation	R-HSA-8876725	6.432303e-01	0.192	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	6.432303e-01	0.192	0
Other semaphorin interactions	R-HSA-416700	6.432303e-01	0.192	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.432303e-01	0.192	0
Formation of the anterior neural plate	R-HSA-9823739	6.432303e-01	0.192	0
DNA Damage Reversal	R-HSA-73942	6.432303e-01	0.192	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.478543e-01	0.189	0
FCERI mediated NF-kB activation	R-HSA-2871837	6.511397e-01	0.186	0
NPAS4 regulates expression of target genes	R-HSA-9768919	6.513173e-01	0.186	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.583108e-01	0.182	0
Activation of SMO	R-HSA-5635838	6.620793e-01	0.179	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.620793e-01	0.179	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	6.620793e-01	0.179	0
Activation of the phototransduction cascade	R-HSA-2485179	6.620793e-01	0.179	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.620793e-01	0.179	0
Fructose catabolism	R-HSA-70350	6.620793e-01	0.179	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.620793e-01	0.179	0
Atorvastatin ADME	R-HSA-9754706	6.620793e-01	0.179	0
Virus Assembly and Release	R-HSA-168268	6.620793e-01	0.179	0
Interleukin-12 signaling	R-HSA-9020591	6.673950e-01	0.176	0
ER to Golgi Anterograde Transport	R-HSA-199977	6.708375e-01	0.173	0
SLC transporter disorders	R-HSA-5619102	6.718054e-01	0.173	0
Neutrophil degranulation	R-HSA-6798695	6.761629e-01	0.170	0
Lysosome Vesicle Biogenesis	R-HSA-432720	6.766758e-01	0.170	0
RET signaling	R-HSA-8853659	6.766758e-01	0.170	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.799335e-01	0.168	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.799335e-01	0.168	0
Fibronectin matrix formation	R-HSA-1566977	6.799335e-01	0.168	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.799335e-01	0.168	0
Passive transport by Aquaporins	R-HSA-432047	6.799335e-01	0.168	0
Gastrulation	R-HSA-9758941	6.835886e-01	0.165	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.853634e-01	0.164	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.887815e-01	0.162	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.887815e-01	0.162	0
Ion channel transport	R-HSA-983712	6.902425e-01	0.161	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.968454e-01	0.157	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.968454e-01	0.157	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.968454e-01	0.157	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.968454e-01	0.157	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.005116e-01	0.155	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.005116e-01	0.155	0
G alpha (s) signalling events	R-HSA-418555	7.014315e-01	0.154	0
C-type lectin receptors (CLRs)	R-HSA-5621481	7.014315e-01	0.154	0
Post-translational protein phosphorylation	R-HSA-8957275	7.035098e-01	0.153	0
L1CAM interactions	R-HSA-373760	7.063948e-01	0.151	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.118722e-01	0.148	0
Pentose phosphate pathway	R-HSA-71336	7.118722e-01	0.148	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.118722e-01	0.148	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.120452e-01	0.147	0
Ephrin signaling	R-HSA-3928664	7.128647e-01	0.147	0
RNA Polymerase III Transcription Termination	R-HSA-73980	7.128647e-01	0.147	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.128647e-01	0.147	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	7.128647e-01	0.147	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	7.128647e-01	0.147	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	7.128647e-01	0.147	0
Synaptic adhesion-like molecules	R-HSA-8849932	7.128647e-01	0.147	0
Platelet sensitization by LDL	R-HSA-432142	7.128647e-01	0.147	0
GAB1 signalosome	R-HSA-180292	7.128647e-01	0.147	0
Apoptotic factor-mediated response	R-HSA-111471	7.128647e-01	0.147	0
tRNA Aminoacylation	R-HSA-379724	7.128858e-01	0.147	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.128858e-01	0.147	0
Metabolism of polyamines	R-HSA-351202	7.128858e-01	0.147	0
Infectious disease	R-HSA-5663205	7.169628e-01	0.145	0
PPARA activates gene expression	R-HSA-1989781	7.199563e-01	0.143	0
Nucleotide salvage	R-HSA-8956321	7.220162e-01	0.141	0
Integration of energy metabolism	R-HSA-163685	7.225147e-01	0.141	0
Signaling by Interleukins	R-HSA-449147	7.225990e-01	0.141	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.228694e-01	0.141	0
HIV Transcription Elongation	R-HSA-167169	7.228694e-01	0.141	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.228694e-01	0.141	0
Diseases of Immune System	R-HSA-5260271	7.228694e-01	0.141	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.228694e-01	0.141	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.280384e-01	0.138	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.280384e-01	0.138	0
Pyrimidine biosynthesis	R-HSA-500753	7.280384e-01	0.138	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.280384e-01	0.138	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.280384e-01	0.138	0
Other interleukin signaling	R-HSA-449836	7.280384e-01	0.138	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.280384e-01	0.138	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.309188e-01	0.136	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.314383e-01	0.136	0
HCMV Late Events	R-HSA-9610379	7.314383e-01	0.136	0
Maturation of spike protein	R-HSA-9694548	7.335100e-01	0.135	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.335100e-01	0.135	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.424112e-01	0.129	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.424112e-01	0.129	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.424112e-01	0.129	0
Co-inhibition by CTLA4	R-HSA-389513	7.424112e-01	0.129	0
Creatine metabolism	R-HSA-71288	7.424112e-01	0.129	0
Protein hydroxylation	R-HSA-9629569	7.424112e-01	0.129	0
Nephrin family interactions	R-HSA-373753	7.424112e-01	0.129	0
Signaling by FGFR1 in disease	R-HSA-5655302	7.438009e-01	0.129	0
MHC class II antigen presentation	R-HSA-2132295	7.516714e-01	0.124	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.520823e-01	0.124	0
Activation of HOX genes during differentiation	R-HSA-5619507	7.527405e-01	0.123	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.527405e-01	0.123	0
ERK/MAPK targets	R-HSA-198753	7.560252e-01	0.121	0
Abacavir metabolism	R-HSA-2161541	7.560252e-01	0.121	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.562788e-01	0.121	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.625109e-01	0.118	0
Signaling by SCF-KIT	R-HSA-1433557	7.633629e-01	0.117	0
Post NMDA receptor activation events	R-HSA-438064	7.633653e-01	0.117	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.689204e-01	0.114	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.689204e-01	0.114	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	7.689204e-01	0.114	0
Kidney development	R-HSA-9830369	7.720936e-01	0.112	0
DAP12 interactions	R-HSA-2172127	7.726489e-01	0.112	0
Proteasome assembly	R-HSA-9907900	7.726489e-01	0.112	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.811348e-01	0.107	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.811348e-01	0.107	0
Fructose metabolism	R-HSA-5652084	7.811348e-01	0.107	0
Signaling by KIT in disease	R-HSA-9669938	7.811348e-01	0.107	0
LDL clearance	R-HSA-8964038	7.811348e-01	0.107	0
Nucleosome assembly	R-HSA-774815	7.816153e-01	0.107	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.816153e-01	0.107	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.816153e-01	0.107	0
Somitogenesis	R-HSA-9824272	7.816153e-01	0.107	0
Cytokine Signaling in Immune system	R-HSA-1280215	7.826297e-01	0.106	0
Base Excision Repair	R-HSA-73884	7.836624e-01	0.106	0
Class B/2 (Secretin family receptors)	R-HSA-373080	7.836624e-01	0.106	0
Condensation of Prophase Chromosomes	R-HSA-2299718	7.902698e-01	0.102	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.902698e-01	0.102	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.902698e-01	0.102	0
Disease	R-HSA-1643685	7.923202e-01	0.101	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.927043e-01	0.101	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.927043e-01	0.101	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.927043e-01	0.101	0
Free fatty acids regulate insulin secretion	R-HSA-400451	7.927043e-01	0.101	0
Carnitine shuttle	R-HSA-200425	7.927043e-01	0.101	0
Formation of the ureteric bud	R-HSA-9830674	7.927043e-01	0.101	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.927043e-01	0.101	0
IRE1alpha activates chaperones	R-HSA-381070	7.964080e-01	0.099	0
Recycling pathway of L1	R-HSA-437239	7.986204e-01	0.098	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.986204e-01	0.098	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.011964e-01	0.096	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.036628e-01	0.095	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.036628e-01	0.095	0
Interleukin-6 family signaling	R-HSA-6783589	8.036628e-01	0.095	0
Adaptive Immune System	R-HSA-1280218	8.047438e-01	0.094	0
Co-stimulation by CD28	R-HSA-389356	8.066750e-01	0.093	0
Metal ion SLC transporters	R-HSA-425410	8.066750e-01	0.093	0
Phospholipid metabolism	R-HSA-1483257	8.067691e-01	0.093	0
Purine catabolism	R-HSA-74259	8.079659e-01	0.093	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.140427e-01	0.089	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	8.140427e-01	0.089	0
Interleukin-7 signaling	R-HSA-1266695	8.140427e-01	0.089	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.145400e-01	0.089	0
Signaling by FGFR in disease	R-HSA-1226099	8.209222e-01	0.086	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.219279e-01	0.085	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	8.219279e-01	0.085	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.238744e-01	0.084	0
MET activates PTK2 signaling	R-HSA-8874081	8.238744e-01	0.084	0
TRP channels	R-HSA-3295583	8.238744e-01	0.084	0
Abacavir ADME	R-HSA-2161522	8.238744e-01	0.084	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	8.244519e-01	0.084	0
Complex IV assembly	R-HSA-9864848	8.291420e-01	0.081	0
Interaction between L1 and Ankyrins	R-HSA-445095	8.331869e-01	0.079	0
Packaging Of Telomere Ends	R-HSA-171306	8.331869e-01	0.079	0
RNA Polymerase I Promoter Opening	R-HSA-73728	8.331869e-01	0.079	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	8.331869e-01	0.079	0
Signaling by BMP	R-HSA-201451	8.331869e-01	0.079	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.331869e-01	0.079	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.331869e-01	0.079	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.420075e-01	0.075	0
Formation of the Early Elongation Complex	R-HSA-113418	8.420075e-01	0.075	0
Telomere Extension By Telomerase	R-HSA-171319	8.420075e-01	0.075	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.420075e-01	0.075	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.420075e-01	0.075	0
Pyroptosis	R-HSA-5620971	8.420075e-01	0.075	0
Interferon gamma signaling	R-HSA-877300	8.437058e-01	0.074	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.446083e-01	0.073	0
Synthesis of bile acids and bile salts	R-HSA-192105	8.464296e-01	0.072	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.500880e-01	0.071	0
DNA methylation	R-HSA-5334118	8.503622e-01	0.070	0
mRNA Capping	R-HSA-72086	8.503622e-01	0.070	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	8.503622e-01	0.070	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.503622e-01	0.070	0
Platelet calcium homeostasis	R-HSA-418360	8.503622e-01	0.070	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.503622e-01	0.070	0
Parasite infection	R-HSA-9664407	8.525531e-01	0.069	0
Leishmania phagocytosis	R-HSA-9664417	8.525531e-01	0.069	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.525531e-01	0.069	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.582756e-01	0.066	0
Neurotransmitter clearance	R-HSA-112311	8.582756e-01	0.066	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.606212e-01	0.065	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.614011e-01	0.065	0
Ion homeostasis	R-HSA-5578775	8.614011e-01	0.065	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.657709e-01	0.063	0
Cargo concentration in the ER	R-HSA-5694530	8.657709e-01	0.063	0
Downstream signal transduction	R-HSA-186763	8.657709e-01	0.063	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.728703e-01	0.059	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.779783e-01	0.057	0
Regulation of beta-cell development	R-HSA-186712	8.779783e-01	0.057	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.779783e-01	0.057	0
FGFR1 mutant receptor activation	R-HSA-1839124	8.795946e-01	0.056	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.795946e-01	0.056	0
Signaling by Retinoic Acid	R-HSA-5362517	8.830845e-01	0.054	0
Acyl chain remodelling of PC	R-HSA-1482788	8.859636e-01	0.053	0
Heme degradation	R-HSA-189483	8.859636e-01	0.053	0
Leishmania infection	R-HSA-9658195	8.902603e-01	0.050	0
Parasitic Infection Pathways	R-HSA-9824443	8.902603e-01	0.050	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.919961e-01	0.050	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.919961e-01	0.050	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.919961e-01	0.050	0
RA biosynthesis pathway	R-HSA-5365859	8.919961e-01	0.050	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.919961e-01	0.050	0
Signaling by PDGF	R-HSA-186797	8.927085e-01	0.049	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.931938e-01	0.049	0
Bile acid and bile salt metabolism	R-HSA-194068	8.966480e-01	0.047	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.972396e-01	0.047	0
Acyl chain remodelling of PE	R-HSA-1482839	8.977098e-01	0.047	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	8.977098e-01	0.047	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.978630e-01	0.047	0
Insulin receptor signalling cascade	R-HSA-74751	9.015919e-01	0.045	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.031216e-01	0.044	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.031216e-01	0.044	0
RNA Polymerase III Transcription	R-HSA-74158	9.031216e-01	0.044	0
Cleavage of the damaged purine	R-HSA-110331	9.082474e-01	0.042	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.082474e-01	0.042	0
Metabolism of folate and pterines	R-HSA-196757	9.082474e-01	0.042	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.111789e-01	0.040	0
Depurination	R-HSA-73927	9.131022e-01	0.039	0
Purine salvage	R-HSA-74217	9.131022e-01	0.039	0
MET promotes cell motility	R-HSA-8875878	9.131022e-01	0.039	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.131022e-01	0.039	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.135278e-01	0.039	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.136381e-01	0.039	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.136381e-01	0.039	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.177005e-01	0.037	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.177005e-01	0.037	0
Mitochondrial protein degradation	R-HSA-9837999	9.204648e-01	0.036	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.220557e-01	0.035	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.220557e-01	0.035	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.220557e-01	0.035	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.236580e-01	0.034	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.247033e-01	0.034	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.261806e-01	0.033	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.261806e-01	0.033	0
ECM proteoglycans	R-HSA-3000178	9.275565e-01	0.033	0
Intra-Golgi traffic	R-HSA-6811438	9.300875e-01	0.031	0
Transmission across Chemical Synapses	R-HSA-112315	9.302590e-01	0.031	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.306897e-01	0.031	0
Aspirin ADME	R-HSA-9749641	9.336944e-01	0.030	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.337879e-01	0.030	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.337879e-01	0.030	0
Depyrimidination	R-HSA-73928	9.337879e-01	0.030	0
Defective pyroptosis	R-HSA-9710421	9.372926e-01	0.028	0
TBC/RABGAPs	R-HSA-8854214	9.372926e-01	0.028	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.393375e-01	0.027	0
Gap junction trafficking	R-HSA-190828	9.406120e-01	0.027	0
Surfactant metabolism	R-HSA-5683826	9.406120e-01	0.027	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.467336e-01	0.024	0
Integrin cell surface interactions	R-HSA-216083	9.469544e-01	0.024	0
Neuronal System	R-HSA-112316	9.490610e-01	0.023	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.495537e-01	0.022	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.515164e-01	0.022	0
Intraflagellar transport	R-HSA-5620924	9.522247e-01	0.021	0
Gap junction trafficking and regulation	R-HSA-157858	9.547545e-01	0.020	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.578841e-01	0.019	0
Degradation of the extracellular matrix	R-HSA-1474228	9.589410e-01	0.018	0
The phototransduction cascade	R-HSA-2514856	9.594196e-01	0.018	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.615688e-01	0.017	0
Nucleotide biosynthesis	R-HSA-8956320	9.636042e-01	0.016	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.647073e-01	0.016	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.655320e-01	0.015	0
Metabolism of nucleotides	R-HSA-15869	9.672124e-01	0.014	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.673578e-01	0.014	0
Paracetamol ADME	R-HSA-9753281	9.673578e-01	0.014	0
IRS-mediated signalling	R-HSA-112399	9.707246e-01	0.013	0
Synthesis of PA	R-HSA-1483166	9.707246e-01	0.013	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.719604e-01	0.012	0
Extension of Telomeres	R-HSA-180786	9.737446e-01	0.012	0
Signaling by Insulin receptor	R-HSA-74752	9.744114e-01	0.011	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.751357e-01	0.011	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.755675e-01	0.011	0
IRS-related events triggered by IGF1R	R-HSA-2428928	9.764533e-01	0.010	0
Collagen degradation	R-HSA-1442490	9.764533e-01	0.010	0
Collagen formation	R-HSA-1474290	9.766730e-01	0.010	0
Chromosome Maintenance	R-HSA-73886	9.771247e-01	0.010	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.777011e-01	0.010	0
Leishmania parasite growth and survival	R-HSA-9664433	9.781625e-01	0.010	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.781625e-01	0.010	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.789587e-01	0.009	0
Metabolism of proteins	R-HSA-392499	9.795515e-01	0.009	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.797067e-01	0.009	0
Telomere Maintenance	R-HSA-157579	9.806303e-01	0.008	0
Asparagine N-linked glycosylation	R-HSA-446203	9.815597e-01	0.008	0
Respiratory electron transport	R-HSA-611105	9.817894e-01	0.008	0
Extracellular matrix organization	R-HSA-1474244	9.828615e-01	0.008	0
Hemostasis	R-HSA-109582	9.833331e-01	0.007	0
Nucleotide catabolism	R-HSA-8956319	9.843349e-01	0.007	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.855769e-01	0.006	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.857449e-01	0.006	0
Developmental Cell Lineages	R-HSA-9734767	9.858688e-01	0.006	0
Cardiac conduction	R-HSA-5576891	9.862117e-01	0.006	0
G alpha (q) signalling events	R-HSA-416476	9.863173e-01	0.006	0
NoRC negatively regulates rRNA expression	R-HSA-427413	9.863417e-01	0.006	0
Retinoid metabolism and transport	R-HSA-975634	9.863417e-01	0.006	0
Metabolism of cofactors	R-HSA-8978934	9.863417e-01	0.006	0
Metabolism of porphyrins	R-HSA-189445	9.863417e-01	0.006	0
Post-translational protein modification	R-HSA-597592	9.870678e-01	0.006	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.884013e-01	0.005	0
SLC-mediated transmembrane transport	R-HSA-425407	9.899042e-01	0.004	0
FCERI mediated MAPK activation	R-HSA-2871796	9.908831e-01	0.004	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.911679e-01	0.004	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.920802e-01	0.003	0
G alpha (i) signalling events	R-HSA-418594	9.924107e-01	0.003	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.928169e-01	0.003	0
Transport of small molecules	R-HSA-382551	9.931813e-01	0.003	0
Peroxisomal lipid metabolism	R-HSA-390918	9.932751e-01	0.003	0
Peptide hormone metabolism	R-HSA-2980736	9.934726e-01	0.003	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.937781e-01	0.003	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.942900e-01	0.002	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.955863e-01	0.002	0
Immune System	R-HSA-168256	9.959285e-01	0.002	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.965052e-01	0.002	0
Sensory perception of taste	R-HSA-9717189	9.969846e-01	0.001	0
Innate Immune System	R-HSA-168249	9.981554e-01	0.001	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.981847e-01	0.001	0
GPCR downstream signalling	R-HSA-388396	9.983656e-01	0.001	0
Visual phototransduction	R-HSA-2187338	9.987505e-01	0.001	0
Bacterial Infection Pathways	R-HSA-9824439	9.988646e-01	0.000	0
Drug ADME	R-HSA-9748784	9.989303e-01	0.000	0
Peptide ligand-binding receptors	R-HSA-375276	9.989515e-01	0.000	0
Arachidonate metabolism	R-HSA-2142753	9.990237e-01	0.000	0
Metabolism of steroids	R-HSA-8957322	9.993962e-01	0.000	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.994238e-01	0.000	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.996665e-01	0.000	0
Signaling by GPCR	R-HSA-372790	9.998245e-01	0.000	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.999053e-01	0.000	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999280e-01	0.000	0
Diseases of metabolism	R-HSA-5668914	9.999677e-01	0.000	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999818e-01	0.000	0
Diseases of glycosylation	R-HSA-3781865	9.999845e-01	0.000	0
Sphingolipid metabolism	R-HSA-428157	9.999939e-01	0.000	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999988e-01	0.000	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999997e-01	0.000	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999998e-01	0.000	0
Fatty acid metabolism	R-HSA-8978868	9.999998e-01	0.000	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0