TLK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A6NMY6	S127	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
O00115	S57	Sugiyama	DNASE2 DNASE2A DNL2	ALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGR
O00115	S58	Sugiyama	DNASE2 DNASE2A DNL2	LRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGRS
O00170	T48	Sugiyama	AIP XAP2	FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00273	S90	Sugiyama	DFFA DFF1 DFF45 H13	VDDDDYFLCLPSNTKFVALAsNEKWAYNNSDGGTAWIsQEs
O00592	T556	Sugiyama	PODXL PCLP PCLP1	DsWIVPLDNLTKDDLDEEEDtHL__________________
O15212	S53	Sugiyama	PFDN6 HKE2 PFD6	LEAQLtENNIVKEELALLDGsNVVFKLLGPVLVKQELGEAR
O43290	T430	Sugiyama	SART1	RKKEKEVVVRADDLLPLGDQtQDGDFGsRLRGRGRRRVsEV
O43615	S193	Sugiyama	TIMM44 MIMT44 TIM44	TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43719	S702	Sugiyama	HTATSF1	EDADGKEVEDADEKLFEDDDsNEKLFDEEEDssEKLFDDsD
O43719	S713	Sugiyama	HTATSF1	DEKLFEDDDsNEKLFDEEEDssEKLFDDsDERGTLGGFGSV
O43852	T177	Sugiyama	CALU	ERRFKMADKDGDLIATKEEFtAFLHPEEyDyMKDIVVQEtM
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852	T254	Sugiyama	CALU	REQFVEFRDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLV
O60231	S106	Sugiyama	DHX16 DBP2 DDX16 KIAA0577 PRP2	EARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRK
O60343	S304	Sugiyama	TBC1D4 AS160 KIAA0603	ASQPALTSSRVCFPERILEDsGFDEQQEFRsRCssVTGVQR
O60610	S542	Sugiyama	DIAPH1 DIAP1	ALHSEKQQIATEKQDLEAEVsQLtGEVAKLTKELEDAKKEM
O60610	S793	Sugiyama	DIAPH1 DIAP1	YKPEVQLRRPNWSKLVAEDLsQDCFWtKVKEDRFENNELFA
O75533	T316	Sugiyama	SF3B1 SAP155	tPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKs
O75534	S782	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	LDDAsAPRLMVLRQPRGPDNsMGFGAERKIRQAGVID____
O75821	T206	Sugiyama	EIF3G EIF3S4	LGLstGEKEKLPGELEPVQAtQNKtGKYVPPsLRDGAsRRG
O75934	T40	Sugiyama	BCAS2 DAM1	DQGYEAPGVREAAAALVEEEtRRYRPTKNYLSYLTAPDYSA
O94888	S288	Sugiyama	UBXN7 KIAA0794 UBXD7	sssPPKKCARsEsLIDAsEDsQLEAAIRASLQETHFDstQT
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95433	T20	Sugiyama	AHSA1 C14orf3 HSPC322	_MAKWGEGDPRWIVEERADAtNVNNWHWtERDASNWSTDKL
O95551	T92	Sugiyama	TDP2 EAP2 TTRAP AD-022	ERRPETISEPKTyVDLtNEEtTDsttsKISPSEDTQQENGS
O95816	S208	Sugiyama	BAG2	IKLLEHSKGAGSKTLQQNAEsRFN_________________
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P02545	S463	Sugiyama	LMNA LMN1	EEVDEEGKFVRLRNKsNEDQsMGNWQIKRQNGDDPLLtYRF
P04040	T441	Sugiyama	CAT	HSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEEQRKRLCE
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	T123	Sugiyama	ALDOA ALDA	GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	T169	Sugiyama	ANXA1 ANX1 LPC1	IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198	T284	Sugiyama	EIF2S1 EIF2A	EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05362	S88	Sugiyama	ICAM1	ELLLPGNNRKVYELSNVQEDsQPMCYSNCPDGQSTAKTFLT
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455	S325	Sugiyama	SSB	VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237	T462	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	tLKFFPAsADRtVIDyNGERtLDGFKKFLESGGQDGAGDDD
P07355	S127	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07602	T26	Sugiyama	PSAP GLBA SAP1	LLASLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVK
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	S85	Sugiyama	PFN1	tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07814	T745	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	KNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVR
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S641	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900	T305	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238	Y457	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08621	S410	Sugiyama	SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1	DEARGGGGGQDNGLEGLGNDsRDMYMESEGGDGYLAPENGY
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08708	Y84	Sugiyama	RPS17 RPS17L	GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P08758	S37	Sugiyama	ANXA5 ANX5 ENX2 PP4	ERADAEtLRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAF
P08758	T40	Sugiyama	ANXA5 ANX5 ENX2 PP4	DAEtLRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAFKTL
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	T51	Sugiyama	TUBA3C TUBA2	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P0DPH7	T73	Sugiyama	TUBA3C TUBA2	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7	T80	Sugiyama	TUBA3C TUBA2	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P0DPH7	T82	Sugiyama	TUBA3C TUBA2	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANN
P0DPH7	Y83	Sugiyama	TUBA3C TUBA2	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANNy
P10109	S148	Sugiyama	FDX1 ADX	DAITDEENDMLDLAyGLTDRsRLGCQICLTKsMDNMTVRVP
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11387	S10	Sugiyama	TOP1	___________MsGDHLHNDsQIEADFRLNDsHKHKDKHKD
P13073	S34	Sugiyama	COX4I1 COX4	AISTSVCVRAHESVVKsEDFsLPAyMDRRDHPLPEVAHVKH
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13667	T380	Sugiyama	PDIA4 ERP70 ERP72	PEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHR
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P14314	T115	Sugiyama	PRKCSH G19P1	GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14314	T134	Sugiyama	PRKCSH G19P1	NtCKEKGRKEREsLQQMAEVtREGFRLKKILIEDWKKAREE
P14314	T78	Sugiyama	PRKCSH G19P1	CKDGSDEPGTAACPNGSFHCtNtGyKPLyIPSNRVNDGVCD
P14625	T522	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	NRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMA
P14649	S87	Sugiyama	MYL6B MLC1SA	EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338	T583	Sugiyama	NCL	sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD
P20042	T31	Sugiyama	EIF2S2 EIF2B	tMsKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtED
P20042	T36	Sugiyama	EIF2S2 EIF2B	KKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKDLEA
P20810	T334	Sugiyama	CAST	EVDEAKAKEEKLEKCGEDDEtIPsEyRLKPATDKDGKPLLP
P23526	T157	Sugiyama	AHCY SAHH	NLIHTKYPQLLPGIRGIsEEtTTGVHNLyKMMANGILKVPA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26639	S522	Sugiyama	TARS1 TARS	PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P26639	T700	Sugiyama	TARS1 TARS	EKISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAE
P27348	S145	Sugiyama	YWHAQ	YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27797	S214	Sugiyama	CALR CRTC	GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S1151	Sugiyama	MAP4	LSGGGDQREAQtLDsQIQEtsI___________________
P27816	S643	Sugiyama	MAP4	IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P27816	T57	Sugiyama	MAP4	VVGETVGKTDyIPLLDVDEKtGNsESKKKPCsEtsQIEDtP
P28340	S1042	Sugiyama	POLD1 POLD	QGAVCEFCQPRESELYQKEVsHLNALEERFSRLWTQCQRCQ
P29083	S284	Sugiyama	GTF2E1 TF2E1	LHRAsLEGKSAKERPIWLREstVQGAYGsEDMKEGGIDMDA
P29083	T285	Sugiyama	GTF2E1 TF2E1	HRAsLEGKSAKERPIWLREstVQGAYGsEDMKEGGIDMDAF
P29401	T342	Sugiyama	TKT	GQALAKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIEC
P29692	S37	Sugiyama	EEF1D EF1D	KYDDAERRFyEQMNGPVAGAsRQENGAsVILRDIARARENI
P30101	S343	Sugiyama	PDIA3 ERP57 ERP60 GRP58	IPVVAIRTAKGEKFVMQEEFsRDGKALERFLQDyFDGNLKR
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31327	T54	Sugiyama	CPS1	PGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPSSVAGEVVFN
P34741	T128	Sugiyama	SDC2 HSPG1	DKEKVHLSDSERKMDPAEEDtNVyTEKHSDSLFKRTEVLAA
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34932	S414	Sugiyama	HSPA4 APG2 HSPH2	ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P35269	S217	Sugiyama	GTF2F1 RAP74	RGRRKASELRIHDLEDDLEMssDAsDAsGEEGGRVPKAKKK
P35579	S1308	Sugiyama	MYH9	LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579	S1915	Sugiyama	MYH9	KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579	T1151	Sugiyama	MYH9	EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI
P35579	T1904	Sugiyama	MYH9	EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579	T1906	Sugiyama	MYH9	AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35580	T1718	Sugiyama	MYH10	SsERARRHAEQERDELADEItNSASGKSALLDEKRRLEARI
P35637	S462	Sugiyama	FUS TLS	NECNQCKAPKPDGPGGGPGGsHMGGNyGDDRRGGRGGYDRG
P35659	S231	Sugiyama	DEK	SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P35659	S306	Sugiyama	DEK	DSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDEELK
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T84	Sugiyama	RPL4 RPL1	AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P36954	S73	Sugiyama	POLR2I	IyVNKITHEVDELtQIIADVsQDPTLPRTEDHPCQKCGHKE
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38398	S1271	Sugiyama	BRCA1 RNF53	CLsKNTEENLLSLKNsLNDCsNQVILAKAsQEHHLsEETKC
P38646	T111	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687	S27	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	IHLELRNRtPsDVKELVLDNsRsNEGKLEGLTDEFEELEFL
P39687	T126	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	IEPLKKLENLKsLDLFNCEVtNLNDyRENVFKLLPQLtyLD
P39687	T143	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	CEVtNLNDyRENVFKLLPQLtyLDGyDRDDKEAPDsDAEGY
P41091	T21	Sugiyama	EIF2S3 EIF2G	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P43243	S234	Sugiyama	MATR3 KIAA0723	yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43243	T239	Sugiyama	MATR3 KIAA0723	yEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGP
P43243	Y243	Sugiyama	MATR3 KIAA0723	RLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGPLQER
P46013	T1967	Sugiyama	MKI67	KAKALEDLAGFKELFQtPGHtEEsMtDDKITEVsCKsPQPD
P46013	T1972	Sugiyama	MKI67	EDLAGFKELFQtPGHtEEsMtDDKITEVsCKsPQPDPVKtP
P46013	T2094	Sugiyama	MKI67	EDLAGFKELFQtPDHTEESttDDKTTKIACKsPPPEsMDtP
P46937	S382	Sugiyama	YAP1 YAP65	QNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstDsGL
P46937	T379	Sugiyama	YAP1 YAP65	GGtQNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstD
P46940	S1448	Sugiyama	IQGAP1 KIAA0051	AIRDAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGLKKLTE
P46940	T1451	Sugiyama	IQGAP1 KIAA0051	DAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGLKKLTELGt
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P54105	S42	Sugiyama	CLNS1A CLCI ICLN	DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P56385	S66	Sugiyama	ATP5ME ATP5I ATP5K	EEKKKQDELKRIARELAEDDsILK_________________
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60660	S30	Sugiyama	MYL6	AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60660	T103	Sugiyama	MYL6	QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61353	T33	Sugiyama	RPL27	VLAGRYSGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKV
P61604	S21	Sugiyama	HSPE1	MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62495	S295	Sugiyama	ETF1 ERF1 RF1 SUP45L1	LSNVKFIQEKKLIGRyFDEIsQDtGKyCFGVEDTLKALEMG
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62854	S57	Sugiyama	RPS26	KKFVIRNIVEAAAVRDIsEAsVFDAyVLPKLYVKLHYCVSC
P62857	S39	Sugiyama	RPS28	GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL
P62857	T38	Sugiyama	RPS28	LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62857	T57	Sugiyama	RPS28	DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220	S31	Sugiyama	RPS21	LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	T51	Sugiyama	TUBA1B	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P78371	T474	Sugiyama	CCT2 99D8.1 CCTB	AGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGIT
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01082	S2115	Sugiyama	SPTBN1 SPTB2	ERKRRPPsPEPstKVsEEAEsQQQWDtsKGEQVsQNGLPAE
Q01082	S35	Sugiyama	SPTBN1 SPTB2	QQQYSDVNNRWDVDDWDNENsSARLFERSRIKALADEREAV
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	T126	Sugiyama	SET	SALLGEEDEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPy
Q02952	T597	Sugiyama	AKAP12 AKAP250	tCLEKGLAEVQQDGEAEEGAtsDGEKKREGVtPWAsFKKMV
Q05682	S129	Sugiyama	CALD1 CAD CDM	KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157	S1064	Sugiyama	TJP1 ZO1	PYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRV
Q08J23	T453	Sugiyama	NSUN2 SAKI TRM4	MPWNKRQPKLQGKSAEtREstQLsPADLTEGKPTDPSKLEs
Q09666	T38	Sugiyama	AHNAK PM227	sGsHGLTIAQRDDGVFVQEVtQNsPAARTGVVKEGDQIVGA
Q12888	S523	Sugiyama	TP53BP1	DLGLsLtGDsCKLMLstsEysQsPKMEsLssHRIDEDGENt
Q13155	S48	Sugiyama	AIMP2 JTV1 PRO0992	PNVHGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYE
Q13242	S178	Sugiyama	SRSF9 SFRS9 SRP30C	MEYALRKLDDTKFRsHEGEtsYIRVYPERstsYGYsRsRSG
Q13263	S479	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13541	S112	Sugiyama	EIF4EBP1	EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13642	T152	Sugiyama	FHL1 SLIM1	CKQVIGtGSFFPKGEDFyCVtCHETKFAKHCVKCNKAITSG
Q13765	S132	Sugiyama	NACA HSD48	YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14151	S207	Sugiyama	SAFB2 KIAA0138	FKNtLEtssLNFKVtPDIEEsLLEPENEKILDILGEtCKsE
Q14152	S1256	Sugiyama	EIF3A EIF3S10 KIAA0139	EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152	S1257	Sugiyama	EIF3A EIF3S10 KIAA0139	DRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRER
Q14152	T1378	Sugiyama	EIF3A EIF3S10 KIAA0139	AEKDREsLRRTKNEtDEDGWttVRR________________
Q14247	S332	Sugiyama	CTTN EMS1	VQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRA
Q14247	T328	Sugiyama	CTTN EMS1	GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q14257	T137	Sugiyama	RCN2 ERC55	VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14671	S175	Sugiyama	PUM1 KIAA0099 PUMH1	TDESSKDGPKGIFLGDQWRDsAWGTsDHsVsQPIMVQRRPG
Q14671	S180	Sugiyama	PUM1 KIAA0099 PUMH1	KDGPKGIFLGDQWRDsAWGTsDHsVsQPIMVQRRPGQsFHV
Q14671	S183	Sugiyama	PUM1 KIAA0099 PUMH1	PKGIFLGDQWRDsAWGTsDHsVsQPIMVQRRPGQsFHVNsE
Q14671	S185	Sugiyama	PUM1 KIAA0099 PUMH1	GIFLGDQWRDsAWGTsDHsVsQPIMVQRRPGQsFHVNsEVN
Q14676	S498	Sugiyama	MDC1 KIAA0170 NFBD1	RALVRAHsEKDQPPFGDsDDsVEADKssPGIHLERsQAstt
Q14676	S763	Sugiyama	MDC1 KIAA0170 NFBD1	LDEPWEVLATQPFCLREsEDsEtQPFDtHLEAyGPCLsPPR
Q14676	T765	Sugiyama	MDC1 KIAA0170 NFBD1	EPWEVLATQPFCLREsEDsEtQPFDtHLEAyGPCLsPPRAI
Q14978	S637	Sugiyama	NOLC1 KIAA0035 NS5ATP13	GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14978	S643	Sugiyama	NOLC1 KIAA0035 NS5ATP13	sPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGERANQVLK
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q15185	S118	Sugiyama	PTGES3 P23 TEBP	WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293	S69	Sugiyama	RCN1 RCN	PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15293	T318	Sugiyama	RCN1 RCN	EKLTKEEILENWNMFVGsQAtNyGEDLtKNHDEL_______
Q15293	T325	Sugiyama	RCN1 RCN	ILENWNMFVGsQAtNyGEDLtKNHDEL______________
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15398	T784	Sugiyama	DLGAP5 DLG7 KIAA0008	LMssPEKNTAsQNsILEEGEtKIsQsELFDNKsLttECHLL
Q15650	S341	Sugiyama	TRIP4 RQT4	RLSKKVTIDFAGRKILEEENsLAEyHSRLDETIQAIANGTL
Q15853	T344	Sugiyama	USF2 BHLHB12	ENALLRAQLQQHNLEMVGEGtRQ__________________
Q16513	T605	Sugiyama	PKN2 PRK2 PRKCL2	GEIDEssELRVLDIPGQDsEtVFDIQNDRNsILPKsQsEyK
Q16531	T1137	Sugiyama	DDB1 XAP1	GSGMKREAtADDLIKVVEELtRIH_________________
Q16576	T10	Sugiyama	RBBP7 RBAP46	___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q2VIR3	T21	Sugiyama	EIF2S3B	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q5JSH3	S71	Sugiyama	WDR44 RPH11	PVQELKQDVSKKIIEsIIEEsQKVLQLEDDsLDSKGKELsD
Q5JSH3	S81	Sugiyama	WDR44 RPH11	KKIIEsIIEEsQKVLQLEDDsLDSKGKELsDQAtAsPIVAR
Q5QJE6	T241	Sugiyama	DNTTIP2 ERBP TDIF2	IVPGNEKQIVGtPVNsEDsDtRQtsHLQARsLsEINKPNFY
Q5RKV6	S14	Sugiyama	EXOSC6 MTR3	_______MPGDHRRIRGPEEsQPPQLyAADEEEAPGTRDPT
Q5T3I0	T356	Sugiyama	GPATCH4 GPATC4	RKKRQQQEEEDLNLEDRGEEtVLGGGTREAESRACSDGRSR
Q5UIP0	T1806	Sugiyama	RIF1	QFLDEHHsVNFHLGLKEDNDtINDsLIVSETKSKENTMQEs
Q5VTR2	S138	Sugiyama	RNF20 BRE1A	GDLLTERKALVVPEPEPDsDsNQERKDDRERGEGQEPAFSF
Q6FI81	S307	Sugiyama	CIAPIN1 CUA001 PRO0915	sCPyLGMPAFKPGEKVLLsDsNLHDA_______________
Q6P996	S779	Sugiyama	PDXDC1 KIAA0251	QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	T51	Sugiyama	TUBA3E	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PEY2	T73	Sugiyama	TUBA3E	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2	T80	Sugiyama	TUBA3E	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6PEY2	T82	Sugiyama	TUBA3E	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASN
Q6PEY2	Y83	Sugiyama	TUBA3E	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASNY
Q6UXH1	S295	Sugiyama	CRELD2 UNQ185/PRO211	KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	T51	Sugiyama	TUBA1A TUBA3	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7KZF4	S473	Sugiyama	SND1 TDRD11	ALVSKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGL
Q7LBC6	S314	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	GCDPASKKLKGDRGEVDsNGsDGGEAsRGPWKGGNASGEPG
Q7LBC6	S320	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	KKLKGDRGEVDsNGsDGGEAsRGPWKGGNASGEPGLDQRAK
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417	T117	Sugiyama	NUFIP2 KIAA1321 PIG1	LNGNAGEREISLKNLssDEAtNPIsRVLNGNQQVVDTsLKQ
Q7Z5K2	T127	Sugiyama	WAPL FOE KIAA0261 WAPAL	EEVTSVLEANSKISHVVVEDtVVsDKCFPLEDTLLGKEKST
Q86TU7	S505	Sugiyama	SETD3 C14orf154	NREYYRQQMEEKAPLPKyEEsNLGLLEssVGDSRLPLVLRN
Q86UE4	S323	Sugiyama	MTDH AEG1 LYRIC	KWNsVsPAsAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDR
Q86UE4	T326	Sugiyama	MTDH AEG1 LYRIC	sVsPAsAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDRsIF
Q86UE4	T331	Sugiyama	MTDH AEG1 LYRIC	sAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDRsIFsGIGs
Q86UE8	S103	Sugiyama	TLK2	KIsDyFEFAGGsAPGtsPGRsVPPVARssPQHsLsNPLPRR
Q86UE8	S111	Sugiyama	TLK2	AGGsAPGtsPGRsVPPVARssPQHsLsNPLPRRVEQPLYGL
Q86UE8	S115	Sugiyama	TLK2	APGtsPGRsVPPVARssPQHsLsNPLPRRVEQPLYGLDGsA
Q86UE8	S117	Sugiyama	TLK2	GtsPGRsVPPVARssPQHsLsNPLPRRVEQPLYGLDGsAAK
Q86UE8	S134	Sugiyama	TLK2	HsLsNPLPRRVEQPLYGLDGsAAKEATEEQSALPTLMSVML
Q86UE8	S307	Sugiyama	TLK2	DKSMQDRLRLGHFtTVRHGAsFtEQWtDGYAFQNLIKQQER
Q86UE8	S450	Sugiyama	TLK2	LERVRNLHIRELKRIHNEDNsQFKDHPTLNDRYLLLHLLGR
Q86UE8	S686	Sugiyama	TLK2	SVGVIFYQCLYGRKPFGHNQsQQDILQENtILKATEVQFPP
Q86UE8	S85	Sugiyama	TLK2	RKAEPYETsQGKGtPRGHKIsDyFEFAGGsAPGtsPGRsVP
Q86UE8	S94	Sugiyama	TLK2	QGKGtPRGHKIsDyFEFAGGsAPGtsPGRsVPPVARssPQH
Q86UE8	S99	Sugiyama	TLK2	PRGHKIsDyFEFAGGsAPGtsPGRsVPPVARssPQHsLsNP
Q86UE8	T161	Sugiyama	TLK2	EEQSALPTLMSVMLAKPRLDtEQLAQRGAGLCFTFVsAQQN
Q86UE8	T300	Sugiyama	TLK2	QEKMACRDKSMQDRLRLGHFtTVRHGAsFtEQWtDGYAFQN
Q86UE8	T309	Sugiyama	TLK2	SMQDRLRLGHFtTVRHGAsFtEQWtDGYAFQNLIKQQERIN
Q86UE8	T313	Sugiyama	TLK2	RLRLGHFtTVRHGAsFtEQWtDGYAFQNLIKQQERINSQRE
Q86UE8	T357	Sugiyama	TLK2	RQRKMLAKRKPPAMGQAPPAtNEQKQRKSKTNGAENETPSS
Q86UE8	T483	Sugiyama	TLK2	LLLHLLGRGGFSEVYKAFDLtEQRYVAVKIHQLNKNWRDEK
Q86UE8	T695	Sugiyama	TLK2	LYGRKPFGHNQsQQDILQENtILKATEVQFPPKPVVTPEAK
Q86UE8	T98	Sugiyama	TLK2	tPRGHKIsDyFEFAGGsAPGtsPGRsVPPVARssPQHsLsN
Q86W92	S1009	Sugiyama	PPFIBP1 KIAA1230	DDMFKDFAARsPsAsItDEDsNV__________________
Q86W92	T798	Sugiyama	PPFIBP1 KIAA1230	VLRINNFEPNCLRRRPsDENtIAPSEVQKWTNHRVMEWLRS
Q8N392	S209	Sugiyama	ARHGAP18	TEsQSLRTNENKYQGRDDEAsNLVGEEKLIPPEETPAPETD
Q8N6T3	S174	Sugiyama	ARFGAP1 ARF1GAP	QsVtAssDKAFEDWLNDDLGsyQGAQGNRyVGFGNtPPPQK
Q8N6T3	S348	Sugiyama	ARFGAP1 ARF1GAP	FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8N6T3	T350	Sugiyama	ARFGAP1 ARF1GAP	ETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSA
Q8N6T3	T354	Sugiyama	ARFGAP1 ARF1GAP	SAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSASTNR
Q8NBK3	S357	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	HRSYCYRYRCAARSQNTPDSsAsNLGFRCAADRLPtMD___
Q8NBK3	S359	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	SYCYRYRCAARSQNTPDSsAsNLGFRCAADRLPtMD_____
Q8NDV7	S883	Sugiyama	TNRC6A CAGH26 KIAA1460 TNRC6	NNHWGEANKKSSsGGsDSDRsVSGWNELGKTSSFTWGNNIN
Q8NE71	S595	Sugiyama	ABCF1 ABC50	TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NEF9	S279	Sugiyama	SRFBP1	EYFDDstEERFYKQSsMSEDsDsGDDFFIGKVRRTRKKESS
Q8NEF9	S281	Sugiyama	SRFBP1	FDDstEERFYKQSsMSEDsDsGDDFFIGKVRRTRKKESSCH
Q8TA86	T168	Sugiyama	RP9	NKRHEKDVRIQQLKQLLEDstSDEDRSSSSSSEGKEKHKKK
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WVC0	S72	Sugiyama	LEO1 RDL	DSGQPSNKELFGDDsEDEGAsHHsGSDNHSERSDNRsEAsE
Q8WWM7	S563	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	EELRKFGAQFKLQPsssPENsLDPFPPRILKEEPKGKEKEV
Q92688	T126	Sugiyama	ANP32B APRIL PHAPI2	LEPLKKLECLKsLDLFNCEVtNLNDyREsVFKLLPQLTYLD
Q92688	Y131	Sugiyama	ANP32B APRIL PHAPI2	KLECLKsLDLFNCEVtNLNDyREsVFKLLPQLTYLDGyDRE
Q92900	S1107	Sugiyama	UPF1 KIAA0221 RENT1	ELsQDSYLGDEFKsQIDVALsQDstyQGERAyQHGGVtGLs
Q92974	S953	Sugiyama	ARHGEF2 KIAA0651 LFP40	PEERLQDssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEE
Q92974	S976	Sugiyama	ARHGEF2 KIAA0651 LFP40	sPPHsPRDFtRMQDIPEEtEsRDGEAVASES__________
Q96B36	T233	Sugiyama	AKT1S1 PRAS40	PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96CT7	S141	Sugiyama	CCDC124	KsHLEVPLEENVNRRVLEEGsVEARTIEDAIAVLsVAEEAA
Q96D15	S76	Sugiyama	RCN3 UNQ239/PRO272	HEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGDGDGW
Q96G46	T82	Sugiyama	DUS3L	PAGNELAEPEAKRIRLEDGQtADGQtEEAAEPGEQLQtQKR
Q96HE7	T148	Sugiyama	ERO1A ERO1L UNQ434/PRO865	IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q99460	S305	Sugiyama	PSMD1	GTVPGsEKDsDsMEtEEKTSsAFVGKtPEAsPEPKDQTLKM
Q99832	T351	Sugiyama	CCT7 CCTH NIP7-1	QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	T51	Sugiyama	TUBA1C TUBA6	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BRA2	S8	Sugiyama	TXNDC17 TXNL5	_____________MARYEEVsVSGFEEFHRAVEQHNGKTIF
Q9BRS2	S21	Sugiyama	RIOK1 RIO1	MDYRRLLMSRVVPGQFDDADssDsENRDLKTVKEKDDILFE
Q9BSJ8	S1086	Sugiyama	ESYT1 FAM62A KIAA0747 MBC2	MsRERELLGKVQLDLAETDLsQGVARWYDLMDNKDKGss__
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVS4	S385	Sugiyama	RIOK2 RIO2	CYCRssGDPEQIKEDsLsEEsADARsFEMTEFNQALEEIKG
Q9BW91	S343	Sugiyama	NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771	SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BY43	T98	Sugiyama	CHMP4A C14orf123 SHAX2 CDA04 HSPC134	QTDGtLStLEFQREAIENATtNAEVLRTMELAAQSMKKAYQ
Q9C086	S127	Sugiyama	INO80B HMGA1L4 PAPA1 ZNHIT4	EEEPMEGVPLEQYRAWLDEDsNLsPsPLRDLsGGLGGQEEE
Q9C0C2	S1054	Sugiyama	TNKS1BP1 KIAA1741 TAB182	HVPDGALGQRDQssWQNsDAsQEVGGHQERQQAGAQGPGsA
Q9C0C2	S1110	Sugiyama	TNKS1BP1 KIAA1741 TAB182	FSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQFGIIGND
Q9C0C2	S1173	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMG
Q9C0C2	S804	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EGSTREWASRCGIGQEEMEAsSsQDQSKVSAPGVLTAQDRV
Q9H4L7	S239	Sugiyama	SMARCAD1 KIAA1122	EDEFNDDQSIKKtRLDHGEEsNEsAEsSsNWEKQESIVLKL
Q9H4L7	T231	Sugiyama	SMARCAD1 KIAA1122	ssssEPyEEDEFNDDQSIKKtRLDHGEEsNEsAEsSsNWEK
Q9H501	S79	Sugiyama	ESF1 ABTAP C20orf6 HDCMC28P	PISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKKKT
Q9H7L9	T91	Sugiyama	SUDS3 SAP45 SDS3	QMYQDKLASLKRQLQQLQEGtLQEYQKRMKKLDQQYKERIR
Q9H814	S226	Sugiyama	PHAX RNUXA	RLGNRPEMNYKGRYEITAEDsQEKVADEISFRLQEPKKDLI
Q9NP61	S374	Sugiyama	ARFGAP3 ARFGAP1	SSYFDEPVELRsssFssWDDssDSyWKKETSKDTETVLKTT
Q9NQC3	T432	Sugiyama	RTN4 KIAA0886 NOGO My043 SP1507	IESNLESKVDKKCFADSLEQtNHEKDSEssNDDTsFPstPE
Q9NRX4	T119	Sugiyama	PHPT1 PHP14 CGI-202 HSPC141	PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NUU7	T73	Sugiyama	DDX19A DDX19L	EDRAAQsLLNKLIRSNLVDNtNQVEVLQRDPNsPLysVKsF
Q9NVP2	S198	GPS6\|SIGNOR\|EPSD\|PSP	ASF1B	CtPIKGLGLPGCIPGLLPENsMDCI________________
Q9NW75	S54	Sugiyama	GPATCH2 GPATC2	sALEESSEQARGGFAEtGDHsRsIsCPLKRQARKRRGRKRR
Q9NW75	S56	Sugiyama	GPATCH2 GPATC2	LEESSEQARGGFAEtGDHsRsIsCPLKRQARKRRGRKRRSY
Q9NXG6	S485	Sugiyama	P4HTM PH4	ARQALFQQEMARLAREGGtDsQPEWALDRAYRDARVEL___
Q9P2E9	T1120	Sugiyama	RRBP1 KIAA1398	PPAPAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEG
Q9P2E9	T1123	Sugiyama	RRBP1 KIAA1398	PAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEGMLR
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI30	S125	Sugiyama	TRMT112 AD-001 HSPC152 HSPC170	RMFPISRGIPNMLLsEEEtEs____________________
Q9UKI8	S679	Sugiyama	TLK1 KIAA0137	SVGVIFFQCLYGRKPFGHNQsQQDILQENtILKATEVQFPV
Q9UKI8	T304	Sugiyama	TLK1 KIAA0137	QEKLSSREKSMQDRLRLGHFtTVRHGASFTEQWTDGFAFQN
Q9UKI8	T688	Sugiyama	TLK1 KIAA0137	LYGRKPFGHNQsQQDILQENtILKATEVQFPVKPVVSSEAK
Q9UMR2	T74	Sugiyama	DDX19B DBP5 DDX19 TDBP	EDRAAQsLLNKLIRSNLVDNtNQVEVLQRDPNsPLysVKsF
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPQ0	S204	Sugiyama	LIMCH1 KIAA1102	DsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRG
Q9UQ35	S2459	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	LLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQSLSSGA
Q9Y294	S192	GPS6\|SIGNOR\|EPSD\|PSP	ASF1A CGI-98 HSPC146	sLLstDALPsAsKGWSTSENsLNVMLESHMDCM________
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y450	S67	Sugiyama	HBS1L HBS1 KIAA1038	KPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDH
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	2.442491e-15	14.612
Cell Cycle, Mitotic	R-HSA-69278	1.139089e-13	12.943
Mitotic Prometaphase	R-HSA-68877	1.211521e-09	8.917
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.704030e-09	8.769
M Phase	R-HSA-68886	1.357470e-08	7.867
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.041006e-08	7.517
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.313457e-08	7.365
Mitotic Anaphase	R-HSA-68882	4.344795e-08	7.362
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.123879e-08	7.290
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.715477e-08	7.173
Signaling by ALK in cancer	R-HSA-9700206	6.715477e-08	7.173
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	8.382905e-08	7.077
Mitotic G2-G2/M phases	R-HSA-453274	1.076823e-07	6.968
Separation of Sister Chromatids	R-HSA-2467813	1.151693e-07	6.939
Aggrephagy	R-HSA-9646399	1.453804e-07	6.837
G2/M Transition	R-HSA-69275	3.280249e-07	6.484
Chromatin organization	R-HSA-4839726	8.488296e-07	6.071
Cellular response to heat stress	R-HSA-3371556	9.355737e-07	6.029
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.147422e-06	5.668
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.223088e-06	5.653
Cell Cycle Checkpoints	R-HSA-69620	2.798427e-06	5.553
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.245416e-06	5.489
Kinesins	R-HSA-983189	4.944757e-06	5.306
PKR-mediated signaling	R-HSA-9833482	6.403069e-06	5.194
Gene expression (Transcription)	R-HSA-74160	6.570216e-06	5.182
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.222830e-06	5.085
Intracellular signaling by second messengers	R-HSA-9006925	1.212093e-05	4.916
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.243000e-05	4.906
Signaling by ERBB2	R-HSA-1227986	1.329024e-05	4.876
Chromatin modifying enzymes	R-HSA-3247509	1.465378e-05	4.834
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.903484e-05	4.720
SWI/SNF chromatin remodelers	R-HSA-9932451	2.166415e-05	4.664
ATP-dependent chromatin remodelers	R-HSA-9932444	2.166415e-05	4.664
Golgi-to-ER retrograde transport	R-HSA-8856688	2.098848e-05	4.678
Signaling by VEGF	R-HSA-194138	2.343419e-05	4.630
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.754708e-05	4.560
MAP kinase activation	R-HSA-450294	4.396014e-05	4.357
Downregulation of ERBB2 signaling	R-HSA-8863795	4.121117e-05	4.385
L1CAM interactions	R-HSA-373760	3.836447e-05	4.416
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.657065e-05	4.437
Selective autophagy	R-HSA-9663891	4.389089e-05	4.358
Post NMDA receptor activation events	R-HSA-438064	3.598790e-05	4.444
Regulation of TP53 Activity	R-HSA-5633007	3.529032e-05	4.452
Apoptotic execution phase	R-HSA-75153	4.549113e-05	4.342
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.146018e-05	4.289
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.017556e-05	4.300
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.545763e-05	4.256
Transcriptional regulation by RUNX1	R-HSA-8878171	5.354952e-05	4.271
Regulation of signaling by CBL	R-HSA-912631	5.860739e-05	4.232
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.849553e-05	4.233
MITF-M-dependent gene expression	R-HSA-9856651	5.828466e-05	4.234
PIP3 activates AKT signaling	R-HSA-1257604	6.413573e-05	4.193
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.650275e-05	4.177
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.831431e-05	4.106
Cellular responses to stress	R-HSA-2262752	7.883854e-05	4.103
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.226923e-05	4.085
Cellular responses to stimuli	R-HSA-8953897	8.449836e-05	4.073
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	8.493626e-05	4.071
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.322573e-05	4.030
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.348316e-05	4.029
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.382123e-05	4.028
Transcriptional Regulation by TP53	R-HSA-3700989	1.040998e-04	3.983
Downregulation of ERBB4 signaling	R-HSA-1253288	1.045595e-04	3.981
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.045595e-04	3.981
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.052396e-04	3.978
Regulation of MECP2 expression and activity	R-HSA-9022692	1.109270e-04	3.955
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.214550e-04	3.916
Amplification of signal from the kinetochores	R-HSA-141424	1.214550e-04	3.916
Interleukin-17 signaling	R-HSA-448424	1.342158e-04	3.872
Transport of connexons to the plasma membrane	R-HSA-190872	1.437819e-04	3.842
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.462983e-04	3.835
DNA Double-Strand Break Repair	R-HSA-5693532	1.642152e-04	3.785
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.685994e-04	3.773
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.685994e-04	3.773
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.826160e-04	3.738
MyD88-independent TLR4 cascade	R-HSA-166166	1.778541e-04	3.750
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.778541e-04	3.750
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.195499e-04	3.658
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.443448e-04	3.612
RNA Polymerase II Transcription	R-HSA-73857	2.514644e-04	3.600
Regulation of PTEN localization	R-HSA-8948747	2.896266e-04	3.538
mRNA Splicing - Major Pathway	R-HSA-72163	2.827702e-04	3.549
AURKA Activation by TPX2	R-HSA-8854518	3.133548e-04	3.504
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.167318e-04	3.499
Myogenesis	R-HSA-525793	3.391790e-04	3.470
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.444214e-04	3.463
Centrosome maturation	R-HSA-380287	3.566656e-04	3.448
p75NTR signals via NF-kB	R-HSA-193639	3.718054e-04	3.430
Attenuation phase	R-HSA-3371568	3.751774e-04	3.426
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.768256e-04	3.424
DNA Repair	R-HSA-73894	3.933223e-04	3.405
Recycling pathway of L1	R-HSA-437239	3.996627e-04	3.398
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	4.030971e-04	3.395
HSF1-dependent transactivation	R-HSA-3371571	4.036280e-04	3.394
FLT3 Signaling	R-HSA-9607240	4.817968e-04	3.317
ESR-mediated signaling	R-HSA-8939211	4.871367e-04	3.312
Mitotic Spindle Checkpoint	R-HSA-69618	5.012406e-04	3.300
Chaperone Mediated Autophagy	R-HSA-9613829	5.141511e-04	3.289
COPI-mediated anterograde transport	R-HSA-6807878	5.356077e-04	3.271
Axon guidance	R-HSA-422475	5.194886e-04	3.284
MITF-M-regulated melanocyte development	R-HSA-9730414	5.116311e-04	3.291
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.434335e-04	3.265
Membrane Trafficking	R-HSA-199991	5.770138e-04	3.239
Estrogen-dependent gene expression	R-HSA-9018519	5.800250e-04	3.237
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.084452e-04	3.216
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.263140e-04	3.203
Nucleotide Excision Repair	R-HSA-5696398	6.303840e-04	3.200
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.422966e-04	3.192
Nervous system development	R-HSA-9675108	7.148753e-04	3.146
Heme signaling	R-HSA-9707616	7.247789e-04	3.140
Oncogene Induced Senescence	R-HSA-2559585	7.305759e-04	3.136
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.635113e-04	3.117
Homology Directed Repair	R-HSA-5693538	7.635113e-04	3.117
Epigenetic regulation of gene expression	R-HSA-212165	8.069177e-04	3.093
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.345320e-04	3.079
Cellular Senescence	R-HSA-2559583	8.486865e-04	3.071
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.405403e-04	3.075
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.758343e-04	3.058
Signaling by PTK6	R-HSA-8848021	8.758343e-04	3.058
Apoptosis	R-HSA-109581	8.712549e-04	3.060
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	8.970621e-04	3.047
mRNA Splicing	R-HSA-72172	9.070742e-04	3.042
HSF1 activation	R-HSA-3371511	9.392762e-04	3.027
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.571183e-04	3.019
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.627348e-04	3.016
NF-kB is activated and signals survival	R-HSA-209560	9.627348e-04	3.016
EPH-Ephrin signaling	R-HSA-2682334	9.714489e-04	3.013
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.044918e-03	2.981
Interleukin-37 signaling	R-HSA-9008059	1.098606e-03	2.959
Signaling by Hippo	R-HSA-2028269	1.207759e-03	2.918
PKMTs methylate histone lysines	R-HSA-3214841	1.212821e-03	2.916
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.213485e-03	2.916
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.249949e-03	2.903
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.264583e-03	2.898
Spry regulation of FGF signaling	R-HSA-1295596	1.365323e-03	2.865
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.400006e-03	2.854
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.400006e-03	2.854
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.400006e-03	2.854
Signal Transduction	R-HSA-162582	1.296602e-03	2.887
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.391889e-03	2.856
Cohesin Loading onto Chromatin	R-HSA-2470946	1.463981e-03	2.834
Dual Incision in GG-NER	R-HSA-5696400	1.484978e-03	2.828
NOD1/2 Signaling Pathway	R-HSA-168638	1.484978e-03	2.828
p75NTR recruits signalling complexes	R-HSA-209543	1.492932e-03	2.826
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.519606e-03	2.818
Josephin domain DUBs	R-HSA-5689877	1.548158e-03	2.810
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.582185e-03	2.801
ISG15 antiviral mechanism	R-HSA-1169408	1.582802e-03	2.801
Deubiquitination	R-HSA-5688426	1.593928e-03	2.798
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.629248e-03	2.788
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.629248e-03	2.788
Ephrin signaling	R-HSA-3928664	1.704663e-03	2.768
Processing of DNA double-strand break ends	R-HSA-5693607	2.026200e-03	2.693
Macroautophagy	R-HSA-1632852	1.854418e-03	2.732
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.967772e-03	2.706
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.130042e-03	2.672
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.279128e-03	2.642
RUNX2 regulates bone development	R-HSA-8941326	2.367693e-03	2.626
Regulation of PTEN gene transcription	R-HSA-8943724	2.367963e-03	2.626
Transcriptional regulation by RUNX3	R-HSA-8878159	2.292370e-03	2.640
Oxidative Stress Induced Senescence	R-HSA-2559580	2.412334e-03	2.618
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.346069e-03	2.630
Cell-Cell communication	R-HSA-1500931	2.298989e-03	2.638
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.292370e-03	2.640
Autophagy	R-HSA-9612973	2.186232e-03	2.660
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.346069e-03	2.630
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.434432e-03	2.614
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.484445e-03	2.605
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.494853e-03	2.603
PTEN Regulation	R-HSA-6807070	2.531688e-03	2.597
S Phase	R-HSA-69242	2.620310e-03	2.582
G2/M Checkpoints	R-HSA-69481	2.646491e-03	2.577
Transcriptional Regulation by MECP2	R-HSA-8986944	2.691698e-03	2.570
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.911931e-03	2.536
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.951212e-03	2.530
Nuclear Envelope Breakdown	R-HSA-2980766	2.974962e-03	2.527
Generic Transcription Pathway	R-HSA-212436	3.086405e-03	2.511
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.241884e-03	2.489
Regulation of KIT signaling	R-HSA-1433559	3.246058e-03	2.489
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.246058e-03	2.489
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.471927e-03	2.459
DNA Damage Bypass	R-HSA-73893	3.291059e-03	2.483
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.661585e-03	2.436
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.353501e-03	2.475
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.432872e-03	2.464
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.555096e-03	2.449
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.675886e-03	2.435
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.702881e-03	2.431
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.702881e-03	2.431
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.702881e-03	2.431
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.703255e-03	2.431
Specification of primordial germ cells	R-HSA-9827857	3.852255e-03	2.414
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.466180e-03	2.350
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.466180e-03	2.350
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.466180e-03	2.350
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.466180e-03	2.350
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.979911e-03	2.400
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.323607e-03	2.364
Programmed Cell Death	R-HSA-5357801	3.976233e-03	2.401
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.574189e-03	2.340
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.585228e-03	2.339
Cell-extracellular matrix interactions	R-HSA-446353	4.585228e-03	2.339
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.589461e-03	2.338
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.590292e-03	2.338
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.631310e-03	2.334
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.648629e-03	2.333
Transcriptional regulation by RUNX2	R-HSA-8878166	4.861935e-03	2.313
FOXO-mediated transcription of cell death genes	R-HSA-9614657	5.211195e-03	2.283
Signaling by SCF-KIT	R-HSA-1433557	5.223414e-03	2.282
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.240688e-03	2.281
Metabolism of RNA	R-HSA-8953854	5.273162e-03	2.278
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.358059e-03	2.271
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	6.262649e-03	2.203
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.262649e-03	2.203
FLT3 signaling by CBL mutants	R-HSA-9706377	6.262649e-03	2.203
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	6.074575e-03	2.216
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.074575e-03	2.216
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.596267e-03	2.252
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.931258e-03	2.227
mRNA 3'-end processing	R-HSA-72187	5.585494e-03	2.253
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.105108e-03	2.214
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.780144e-03	2.238
Pexophagy	R-HSA-9664873	6.074575e-03	2.216
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.931258e-03	2.227
Activation of ATR in response to replication stress	R-HSA-176187	5.780144e-03	2.238
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.596267e-03	2.252
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.839217e-03	2.234
Cytokine Signaling in Immune system	R-HSA-1280215	5.812502e-03	2.236
EPHB-mediated forward signaling	R-HSA-3928662	6.270351e-03	2.203
Organelle biogenesis and maintenance	R-HSA-1852241	6.301991e-03	2.201
MECP2 regulates transcription factors	R-HSA-9022707	6.522958e-03	2.186
MAPK6/MAPK4 signaling	R-HSA-5687128	6.745112e-03	2.171
Ovarian tumor domain proteases	R-HSA-5689896	6.882792e-03	2.162
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.919381e-03	2.160
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.919381e-03	2.160
Translesion Synthesis by POLH	R-HSA-110320	6.919381e-03	2.160
Clathrin-mediated endocytosis	R-HSA-8856828	6.985827e-03	2.156
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.036034e-03	2.153
Gap junction trafficking and regulation	R-HSA-157858	7.036034e-03	2.153
Dual incision in TC-NER	R-HSA-6782135	7.203853e-03	2.142
Signaling by KIT in disease	R-HSA-9669938	7.235659e-03	2.141
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.235659e-03	2.141
Notch-HLH transcription pathway	R-HSA-350054	7.235659e-03	2.141
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.285988e-03	2.138
Fanconi Anemia Pathway	R-HSA-6783310	7.481144e-03	2.126
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.191814e-03	2.087
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.191814e-03	2.087
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.331436e-03	2.079
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.368327e-03	2.077
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.389157e-03	2.076
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.517734e-03	2.070
Disorders of Developmental Biology	R-HSA-9675151	8.517734e-03	2.070
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	8.517734e-03	2.070
Interferon Signaling	R-HSA-913531	8.715534e-03	2.060
Cilium Assembly	R-HSA-5617833	8.751397e-03	2.058
PECAM1 interactions	R-HSA-210990	8.898251e-03	2.051
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.071004e-02	1.970
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.071004e-02	1.970
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.071004e-02	1.970
Nephrin family interactions	R-HSA-373753	9.031893e-03	2.044
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.031893e-03	2.044
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	9.031893e-03	2.044
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	9.031893e-03	2.044
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	9.031893e-03	2.044
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	9.031893e-03	2.044
EPHA-mediated growth cone collapse	R-HSA-3928663	9.194559e-03	2.036
Interaction between L1 and Ankyrins	R-HSA-445095	9.194559e-03	2.036
Nuclear Receptor transcription pathway	R-HSA-383280	9.134407e-03	2.039
G1/S Transition	R-HSA-69206	1.010371e-02	1.996
Cell junction organization	R-HSA-446728	9.097472e-03	2.041
Signaling by EGFR	R-HSA-177929	1.052994e-02	1.978
Evasion by RSV of host interferon responses	R-HSA-9833109	9.002439e-03	2.046
p75 NTR receptor-mediated signalling	R-HSA-193704	9.416462e-03	2.026
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.010255e-02	1.996
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.448223e-03	2.025
G0 and Early G1	R-HSA-1538133	1.102057e-02	1.958
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.107679e-02	1.956
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.109722e-02	1.955
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.109722e-02	1.955
RNA Polymerase II Transcription Termination	R-HSA-73856	1.123199e-02	1.950
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.160558e-02	1.935
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.160558e-02	1.935
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.160558e-02	1.935
TCR signaling	R-HSA-202403	1.202860e-02	1.920
Co-stimulation by CD28	R-HSA-389356	1.227540e-02	1.911
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.258161e-02	1.900
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.258161e-02	1.900
Signaling by TGFB family members	R-HSA-9006936	1.298225e-02	1.887
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.320837e-02	1.879
Gap junction trafficking	R-HSA-190828	1.320837e-02	1.879
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.337325e-02	1.874
DCC mediated attractive signaling	R-HSA-418885	1.397352e-02	1.855
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.397352e-02	1.855
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.397352e-02	1.855
Translesion synthesis by REV1	R-HSA-110312	1.397352e-02	1.855
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.398295e-02	1.854
Termination of translesion DNA synthesis	R-HSA-5656169	1.398295e-02	1.854
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.409529e-02	1.851
Polo-like kinase mediated events	R-HSA-156711	1.459681e-02	1.836
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.459681e-02	1.836
Mitotic Prophase	R-HSA-68875	1.480016e-02	1.830
GP1b-IX-V activation signalling	R-HSA-430116	1.489436e-02	1.827
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.489436e-02	1.827
XBP1(S) activates chaperone genes	R-HSA-381038	1.530061e-02	1.815
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.756414e-02	1.755
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.693968e-02	1.771
Nef and signal transduction	R-HSA-164944	1.693968e-02	1.771
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	1.693968e-02	1.771
Signaling by LTK in cancer	R-HSA-9842640	1.693968e-02	1.771
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.725138e-02	1.763
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.725138e-02	1.763
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.725138e-02	1.763
Pervasive developmental disorders	R-HSA-9005895	1.725138e-02	1.763
Disorders of Nervous System Development	R-HSA-9697154	1.725138e-02	1.763
IRAK1 recruits IKK complex	R-HSA-937039	1.725138e-02	1.763
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.725138e-02	1.763
Translesion synthesis by POLI	R-HSA-5656121	1.834851e-02	1.736
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.919505e-02	1.717
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.617444e-02	1.791
Activation of the pre-replicative complex	R-HSA-68962	1.699372e-02	1.770
Hedgehog 'off' state	R-HSA-5610787	1.771326e-02	1.752
Metalloprotease DUBs	R-HSA-5689901	1.778039e-02	1.750
Late Phase of HIV Life Cycle	R-HSA-162599	1.588819e-02	1.799
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.596888e-02	1.797
Signaling by NOTCH2	R-HSA-1980145	1.921561e-02	1.716
Signaling by NTRKs	R-HSA-166520	1.713749e-02	1.766
Negative regulation of FLT3	R-HSA-9706369	1.834851e-02	1.736
Diseases of DNA repair	R-HSA-9675135	1.804621e-02	1.744
Gap junction assembly	R-HSA-190861	1.921561e-02	1.716
Signaling by MET	R-HSA-6806834	2.070731e-02	1.684
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.092470e-02	1.679
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.107120e-02	1.676
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	2.107120e-02	1.676
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.107120e-02	1.676
Transcriptional Regulation by E2F6	R-HSA-8953750	2.113080e-02	1.675
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.121320e-02	1.673
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.209106e-02	1.656
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.277177e-02	1.643
Regulation of CDH1 Function	R-HSA-9764561	2.307016e-02	1.637
HIV Life Cycle	R-HSA-162587	2.330370e-02	1.633
Co-inhibition by CTLA4	R-HSA-389513	2.339578e-02	1.631
Negative regulation of MET activity	R-HSA-6807004	2.339578e-02	1.631
Translesion synthesis by POLK	R-HSA-5655862	2.362524e-02	1.627
ER to Golgi Anterograde Transport	R-HSA-199977	2.397214e-02	1.620
DNA Double Strand Break Response	R-HSA-5693606	2.454598e-02	1.610
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.472276e-02	1.607
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.472276e-02	1.607
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.507842e-02	1.601
RUNX3 regulates WNT signaling	R-HSA-8951430	2.519592e-02	1.599
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.519592e-02	1.599
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.519592e-02	1.599
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.519592e-02	1.599
Cation-coupled Chloride cotransporters	R-HSA-426117	2.519592e-02	1.599
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.574911e-02	1.589
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.574911e-02	1.589
Cyclin D associated events in G1	R-HSA-69231	2.635699e-02	1.579
G1 Phase	R-HSA-69236	2.635699e-02	1.579
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.679454e-02	1.572
Regulation of TP53 Degradation	R-HSA-6804757	2.679454e-02	1.572
Semaphorin interactions	R-HSA-373755	2.700234e-02	1.569
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.761475e-02	1.559
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.765251e-02	1.558
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.844067e-02	1.546
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.871492e-02	1.542
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.871492e-02	1.542
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.871492e-02	1.542
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.874922e-02	1.541
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.874922e-02	1.541
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.878283e-02	1.541
IRE1alpha activates chaperones	R-HSA-381070	2.893150e-02	1.539
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.895720e-02	1.538
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.895720e-02	1.538
ERK/MAPK targets	R-HSA-198753	2.898420e-02	1.538
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.898420e-02	1.538
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.898420e-02	1.538
Metabolism of non-coding RNA	R-HSA-194441	2.971341e-02	1.527
snRNP Assembly	R-HSA-191859	2.971341e-02	1.527
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	3.001084e-02	1.523
NRIF signals cell death from the nucleus	R-HSA-205043	3.001084e-02	1.523
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.001084e-02	1.523
MHC class II antigen presentation	R-HSA-2132295	3.038723e-02	1.517
Late endosomal microautophagy	R-HSA-9615710	3.117226e-02	1.506
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.136783e-02	1.504
G2/M DNA damage checkpoint	R-HSA-69473	3.136783e-02	1.504
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.566353e-02	1.448
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.829620e-02	1.417
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.829620e-02	1.417
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.719763e-02	1.429
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.337291e-02	1.477
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.691378e-02	1.433
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.691378e-02	1.433
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.404465e-02	1.468
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.973810e-02	1.401
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.196458e-02	1.377
Circadian clock	R-HSA-9909396	3.212353e-02	1.493
Oncogenic MAPK signaling	R-HSA-6802957	3.519671e-02	1.453
Signaling by EGFR in Cancer	R-HSA-1643713	3.987326e-02	1.399
MTOR signalling	R-HSA-165159	3.821066e-02	1.418
TGFBR3 expression	R-HSA-9839394	3.337291e-02	1.477
MAPK family signaling cascades	R-HSA-5683057	3.920448e-02	1.407
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.140674e-02	1.383
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.352609e-02	1.475
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.352609e-02	1.475
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.352609e-02	1.475
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.352609e-02	1.475
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.078025e-02	1.390
HIV Infection	R-HSA-162906	4.042084e-02	1.393
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.196458e-02	1.377
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.544565e-02	1.450
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.829620e-02	1.417
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.352609e-02	1.475
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.719763e-02	1.429
Signaling by PDGFR in disease	R-HSA-9671555	3.544565e-02	1.450
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.856380e-02	1.414
Modulation by Mtb of host immune system	R-HSA-9637628	3.566353e-02	1.448
Toll-like Receptor Cascades	R-HSA-168898	4.228285e-02	1.374
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	4.276579e-02	1.369
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	4.276579e-02	1.369
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	4.276579e-02	1.369
Diseases of Telomere Maintenance	R-HSA-9673013	4.276579e-02	1.369
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	4.276579e-02	1.369
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	4.276579e-02	1.369
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	4.276579e-02	1.369
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	4.276579e-02	1.369
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	4.276579e-02	1.369
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.283187e-02	1.368
Aryl hydrocarbon receptor signalling	R-HSA-8937144	4.326485e-02	1.364
IkBA variant leads to EDA-ID	R-HSA-5603029	4.326485e-02	1.364
Maturation of protein E	R-HSA-9683683	4.326485e-02	1.364
Maturation of protein E	R-HSA-9694493	4.326485e-02	1.364
EGFR downregulation	R-HSA-182971	4.335693e-02	1.363
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.335693e-02	1.363
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.335693e-02	1.363
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.369433e-02	1.360
Signaling by Interleukins	R-HSA-449147	4.460106e-02	1.351
Adherens junctions interactions	R-HSA-418990	4.496869e-02	1.347
Rap1 signalling	R-HSA-392517	4.562479e-02	1.341
Cell-cell junction organization	R-HSA-421270	4.580226e-02	1.339
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.600801e-02	1.337
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.719316e-02	1.326
Regulation of BACH1 activity	R-HSA-9708530	4.795328e-02	1.319
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.814602e-02	1.317
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.814602e-02	1.317
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.846171e-02	1.315
Unwinding of DNA	R-HSA-176974	4.846171e-02	1.315
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.846171e-02	1.315
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.926131e-02	1.307
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.926131e-02	1.307
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.940373e-02	1.306
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.940373e-02	1.306
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.940373e-02	1.306
Host Interactions of HIV factors	R-HSA-162909	4.964388e-02	1.304
Interleukin-1 family signaling	R-HSA-446652	5.064402e-02	1.295
Degradation of CDH1	R-HSA-9766229	5.085003e-02	1.294
Syndecan interactions	R-HSA-3000170	5.118635e-02	1.291
Signaling by ERBB4	R-HSA-1236394	5.240223e-02	1.281
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.289800e-02	1.277
GPVI-mediated activation cascade	R-HSA-114604	5.305780e-02	1.275
RET signaling	R-HSA-8853659	5.305780e-02	1.275
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.492900e-02	1.260
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.492900e-02	1.260
Signal transduction by L1	R-HSA-445144	5.521335e-02	1.258
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.536598e-02	1.257
DAG and IP3 signaling	R-HSA-1489509	5.627460e-02	1.250
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.715341e-02	1.243
Protein ubiquitination	R-HSA-8852135	5.771214e-02	1.239
Death Receptor Signaling	R-HSA-73887	5.779867e-02	1.238
FGFR1 mutant receptor activation	R-HSA-1839124	5.846980e-02	1.233
IPs transport between nucleus and cytosol	R-HSA-1855170	5.846980e-02	1.233
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.846980e-02	1.233
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.846980e-02	1.233
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.903295e-02	1.229
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.039609e-02	1.219
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.073241e-02	1.217
Neurofascin interactions	R-HSA-447043	6.126053e-02	1.213
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.126053e-02	1.213
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.216939e-02	1.206
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.216939e-02	1.206
Signaling by FGFR1 in disease	R-HSA-5655302	6.233251e-02	1.205
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.233251e-02	1.205
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.233251e-02	1.205
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.233251e-02	1.205
HIV Transcription Initiation	R-HSA-167161	6.233251e-02	1.205
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.233251e-02	1.205
Negative regulation of MAPK pathway	R-HSA-5675221	6.233251e-02	1.205
Signaling by NOTCH1	R-HSA-1980143	6.338742e-02	1.198
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.340694e-02	1.198
Regulation of the apoptosome activity	R-HSA-9627069	6.364278e-02	1.196
MET activates RAP1 and RAC1	R-HSA-8875555	6.364278e-02	1.196
Formation of apoptosome	R-HSA-111458	6.364278e-02	1.196
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	6.388966e-02	1.195
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.424587e-02	1.192
Signaling by FGFR1	R-HSA-5654736	6.437827e-02	1.191
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.437827e-02	1.191
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.441815e-02	1.191
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.442255e-02	1.191
Resolution of D-Loop Structures	R-HSA-5693537	6.718770e-02	1.173
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.718770e-02	1.173
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.764994e-02	1.170
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.910894e-02	1.160
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.018142e-02	1.154
Sema4D in semaphorin signaling	R-HSA-400685	7.092727e-02	1.149
Interleukin-7 signaling	R-HSA-1266695	7.092727e-02	1.149
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.112009e-02	1.148
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.146131e-02	1.146
PI3K events in ERBB2 signaling	R-HSA-1963642	7.156454e-02	1.145
AKT-mediated inactivation of FOXO1A	R-HSA-211163	7.601159e-02	1.119
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	7.601159e-02	1.119
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	7.601159e-02	1.119
Inhibition of TSC complex formation by PKB	R-HSA-165181	7.601159e-02	1.119
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.075956e-01	0.968
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.075956e-01	0.968
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	8.260974e-02	1.083
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.071068e-01	0.970
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.119487e-02	1.090
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.119487e-02	1.090
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.689204e-02	1.114
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.689204e-02	1.114
p38MAPK events	R-HSA-171007	9.341227e-02	1.030
ERBB2 Regulates Cell Motility	R-HSA-6785631	9.341227e-02	1.030
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.555545e-02	1.068
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.555545e-02	1.068
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.799422e-02	1.108
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.009915e-01	0.996
mTORC1-mediated signalling	R-HSA-166208	9.120972e-02	1.040
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	9.120972e-02	1.040
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.235201e-02	1.084
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.235201e-02	1.084
DAP12 signaling	R-HSA-2424491	7.436869e-02	1.129
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.482089e-02	1.023
Nuclear signaling by ERBB4	R-HSA-1251985	8.801692e-02	1.055
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.801692e-02	1.055
RNA Polymerase II Promoter Escape	R-HSA-73776	7.905983e-02	1.102
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.940479e-02	1.100
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.840773e-02	1.007
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.840773e-02	1.007
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.840773e-02	1.007
Signaling by RAF1 mutants	R-HSA-9656223	1.098316e-01	0.959
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.098316e-01	0.959
Signaling by RAS mutants	R-HSA-6802949	1.090721e-01	0.962
Signaling downstream of RAS mutants	R-HSA-9649948	1.090721e-01	0.962
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.090721e-01	0.962
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.090721e-01	0.962
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.582188e-02	1.019
Chaperonin-mediated protein folding	R-HSA-390466	7.358927e-02	1.133
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.010473e-01	0.995
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.056328e-01	0.976
UCH proteinases	R-HSA-5689603	9.946971e-02	1.002
DNA strand elongation	R-HSA-69190	9.700191e-02	1.013
Signaling by Nuclear Receptors	R-HSA-9006931	9.852292e-02	1.006
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.010473e-01	0.995
Regulation of necroptotic cell death	R-HSA-5675482	1.096831e-01	0.960
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.172211e-02	1.038
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.043811e-01	0.981
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.482089e-02	1.023
FLT3 signaling through SRC family kinases	R-HSA-9706374	7.601159e-02	1.119
Regulation of T cell activation by CD28 family	R-HSA-388841	1.008230e-01	0.996
HATs acetylate histones	R-HSA-3214847	9.622196e-02	1.017
Suppression of apoptosis	R-HSA-9635465	8.119487e-02	1.090
Vesicle-mediated transport	R-HSA-5653656	8.609661e-02	1.065
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.702458e-02	1.060
Intraflagellar transport	R-HSA-5620924	7.942482e-02	1.100
Response of endothelial cells to shear stress	R-HSA-9860931	9.395548e-02	1.027
Calmodulin induced events	R-HSA-111933	9.815676e-02	1.008
Signaling by Hedgehog	R-HSA-5358351	7.720928e-02	1.112
Gastrulation	R-HSA-9758941	8.305756e-02	1.081
Signalling to ERKs	R-HSA-187687	8.702458e-02	1.060
CaM pathway	R-HSA-111997	9.815676e-02	1.008
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.852294e-02	1.105
Signaling by FGFR4	R-HSA-5654743	7.905983e-02	1.102
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.235201e-02	1.084
ROBO receptors bind AKAP5	R-HSA-9010642	1.071068e-01	0.970
Signaling by FGFR3	R-HSA-5654741	9.840773e-02	1.007
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.071068e-01	0.970
Interactions of Rev with host cellular proteins	R-HSA-177243	8.801692e-02	1.055
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.071068e-01	0.970
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.820087e-02	1.107
Nuclear import of Rev protein	R-HSA-180746	7.670273e-02	1.115
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.777537e-02	1.109
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.750355e-02	1.011
Unfolded Protein Response (UPR)	R-HSA-381119	8.225058e-02	1.085
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.107294e-01	0.956
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.116805e-01	0.952
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.116805e-01	0.952
Regulation of NF-kappa B signaling	R-HSA-9758274	1.116805e-01	0.952
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.116805e-01	0.952
SARS-CoV-1-host interactions	R-HSA-9692914	1.152943e-01	0.938
Protein folding	R-HSA-391251	1.165948e-01	0.933
Formation of definitive endoderm	R-HSA-9823730	1.178377e-01	0.929
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.178377e-01	0.929
Potential therapeutics for SARS	R-HSA-9679191	1.203046e-01	0.920
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.203926e-01	0.919
Ca-dependent events	R-HSA-111996	1.218229e-01	0.914
Transcription of the HIV genome	R-HSA-167172	1.220995e-01	0.913
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.228512e-01	0.911
RUNX3 regulates p14-ARF	R-HSA-8951936	1.230778e-01	0.910
Striated Muscle Contraction	R-HSA-390522	1.232596e-01	0.909
G1/S DNA Damage Checkpoints	R-HSA-69615	1.247960e-01	0.904
Sensory processing of sound	R-HSA-9659379	1.258577e-01	0.900
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.269188e-01	0.896
Beta-catenin independent WNT signaling	R-HSA-3858494	1.312450e-01	0.882
Ub-specific processing proteases	R-HSA-5689880	1.316122e-01	0.881
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.316176e-01	0.881
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.316176e-01	0.881
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.316176e-01	0.881
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.316176e-01	0.881
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.344591e-01	0.871
Inactivation of CDC42 and RAC1	R-HSA-428543	1.344591e-01	0.871
Calcineurin activates NFAT	R-HSA-2025928	1.344591e-01	0.871
Regulation of CDH11 gene transcription	R-HSA-9762293	1.344591e-01	0.871
Response of Mtb to phagocytosis	R-HSA-9637690	1.345234e-01	0.871
Cellular responses to mechanical stimuli	R-HSA-9855142	1.354018e-01	0.868
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.363564e-01	0.865
Downstream TCR signaling	R-HSA-202424	1.375910e-01	0.861
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.377109e-01	0.861
NPAS4 regulates expression of target genes	R-HSA-9768919	1.377109e-01	0.861
Long-term potentiation	R-HSA-9620244	1.379885e-01	0.860
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.383669e-01	0.859
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.383669e-01	0.859
FOXO-mediated transcription	R-HSA-9614085	1.388318e-01	0.858
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.389691e-01	0.857
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.428739e-01	0.845
Cyclin E associated events during G1/S transition	R-HSA-69202	1.428739e-01	0.845
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.433355e-01	0.844
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.433355e-01	0.844
Phosphorylation of Emi1	R-HSA-176417	1.433355e-01	0.844
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.433355e-01	0.844
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.433355e-01	0.844
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.433355e-01	0.844
CD28 dependent Vav1 pathway	R-HSA-389359	1.471212e-01	0.832
Formation of axial mesoderm	R-HSA-9796292	1.471212e-01	0.832
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.471212e-01	0.832
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.471212e-01	0.832
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.471212e-01	0.832
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.471212e-01	0.832
Glycolysis	R-HSA-70171	1.479077e-01	0.830
Drug resistance of KIT mutants	R-HSA-9669937	1.502132e-01	0.823
KIT mutants bind TKIs	R-HSA-9669921	1.502132e-01	0.823
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.502132e-01	0.823
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.502132e-01	0.823
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.502132e-01	0.823
Imatinib-resistant KIT mutants	R-HSA-9669917	1.502132e-01	0.823
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.502132e-01	0.823
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.502132e-01	0.823
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.502132e-01	0.823
Masitinib-resistant KIT mutants	R-HSA-9669924	1.502132e-01	0.823
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.531185e-01	0.815
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.531185e-01	0.815
Regulation of NPAS4 gene expression	R-HSA-9768759	1.531185e-01	0.815
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.539589e-01	0.813
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.548363e-01	0.810
Budding and maturation of HIV virion	R-HSA-162588	1.548363e-01	0.810
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.555267e-01	0.808
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.555267e-01	0.808
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.558318e-01	0.807
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.558318e-01	0.807
Regulation of RAS by GAPs	R-HSA-5658442	1.581894e-01	0.801
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.643125e-01	0.784
Regulation of CDH11 function	R-HSA-9762292	1.643125e-01	0.784
PI3K/AKT activation	R-HSA-198203	1.643125e-01	0.784
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.643125e-01	0.784
Signal attenuation	R-HSA-74749	1.643125e-01	0.784
SARS-CoV-2-host interactions	R-HSA-9705683	1.647142e-01	0.783
Transcriptional Regulation by VENTX	R-HSA-8853884	1.656596e-01	0.781
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.656596e-01	0.781
NRAGE signals death through JNK	R-HSA-193648	1.673734e-01	0.776
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.673734e-01	0.776
MGMT-mediated DNA damage reversal	R-HSA-5657655	2.778697e-01	0.556
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.778697e-01	0.556
TICAM1 deficiency - HSE	R-HSA-5602566	2.778697e-01	0.556
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.778697e-01	0.556
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.778697e-01	0.556
Hereditary fructose intolerance	R-HSA-5657560	2.778697e-01	0.556
Signaling by FGFR1 amplification mutants	R-HSA-1839120	1.961748e-01	0.707
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.961748e-01	0.707
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.961748e-01	0.707
CREB phosphorylation	R-HSA-199920	1.823538e-01	0.739
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.823538e-01	0.739
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.823538e-01	0.739
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	2.556276e-01	0.592
Regulation of gap junction activity	R-HSA-191650	2.556276e-01	0.592
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.556276e-01	0.592
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.556276e-01	0.592
Signaling by MAP2K mutants	R-HSA-9652169	2.556276e-01	0.592
Activated NTRK2 signals through CDK5	R-HSA-9032845	2.237802e-01	0.650
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.237802e-01	0.650
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.237802e-01	0.650
IFNG signaling activates MAPKs	R-HSA-9732724	2.237802e-01	0.650
Recycling of eIF2:GDP	R-HSA-72731	2.237802e-01	0.650
SOS-mediated signalling	R-HSA-112412	2.237802e-01	0.650
ChREBP activates metabolic gene expression	R-HSA-163765	1.962745e-01	0.707
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.962745e-01	0.707
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.153624e-01	0.501
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.153624e-01	0.501
NrCAM interactions	R-HSA-447038	3.153624e-01	0.501
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.153624e-01	0.501
IRS activation	R-HSA-74713	3.153624e-01	0.501
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.153624e-01	0.501
G2 Phase	R-HSA-68911	3.153624e-01	0.501
NTRK2 activates RAC1	R-HSA-9032759	3.153624e-01	0.501
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	3.153624e-01	0.501
Activated NTRK2 signals through FYN	R-HSA-9032500	2.667935e-01	0.574
Type I hemidesmosome assembly	R-HSA-446107	2.667935e-01	0.574
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.667935e-01	0.574
Formation of annular gap junctions	R-HSA-196025	2.667935e-01	0.574
MET receptor recycling	R-HSA-8875656	2.667935e-01	0.574
ERKs are inactivated	R-HSA-202670	2.299338e-01	0.638
PI3K events in ERBB4 signaling	R-HSA-1250342	2.299338e-01	0.638
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.299338e-01	0.638
Signaling by GSK3beta mutants	R-HSA-5339716	2.299338e-01	0.638
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.004242e-01	0.698
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.004242e-01	0.698
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.648773e-01	0.577
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.648773e-01	0.577
Scavenging by Class F Receptors	R-HSA-3000484	2.648773e-01	0.577
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.648773e-01	0.577
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.648773e-01	0.577
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.648773e-01	0.577
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.648773e-01	0.577
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.106474e-01	0.508
Lipophagy	R-HSA-9613354	3.106474e-01	0.508
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.106474e-01	0.508
Gap junction degradation	R-HSA-190873	3.106474e-01	0.508
ALK mutants bind TKIs	R-HSA-9700645	3.106474e-01	0.508
Regulation of PTEN mRNA translation	R-HSA-8943723	1.979919e-01	0.703
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.591086e-01	0.587
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.591086e-01	0.587
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.591086e-01	0.587
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.007024e-01	0.522
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.007024e-01	0.522
TRAF6 mediated NF-kB activation	R-HSA-933542	2.207594e-01	0.656
G1/S-Specific Transcription	R-HSA-69205	1.691193e-01	0.772
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.691193e-01	0.772
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.152477e-01	0.667
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.152477e-01	0.667
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.860002e-01	0.730
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.898438e-01	0.538
mRNA Splicing - Minor Pathway	R-HSA-72165	1.766972e-01	0.753
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.370280e-01	0.472
CRMPs in Sema3A signaling	R-HSA-399956	3.370280e-01	0.472
Removal of the Flap Intermediate	R-HSA-69166	3.370280e-01	0.472
GAB1 signalosome	R-HSA-180292	3.211746e-01	0.493
Platelet sensitization by LDL	R-HSA-432142	3.211746e-01	0.493
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.589397e-01	0.587
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.496125e-01	0.603
Regulation of PTEN stability and activity	R-HSA-8948751	2.013618e-01	0.696
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.937618e-01	0.532
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.937618e-01	0.532
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.937618e-01	0.532
HIV elongation arrest and recovery	R-HSA-167287	3.192363e-01	0.496
Pausing and recovery of HIV elongation	R-HSA-167290	3.192363e-01	0.496
MAP2K and MAPK activation	R-HSA-5674135	2.801435e-01	0.553
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.491910e-01	0.603
Ribosomal scanning and start codon recognition	R-HSA-72702	2.491910e-01	0.603
Transcriptional regulation by small RNAs	R-HSA-5578749	2.378317e-01	0.624
Formation of RNA Pol II elongation complex	R-HSA-112382	2.766765e-01	0.558
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.832044e-01	0.548
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.832044e-01	0.548
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.949082e-01	0.530
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.949082e-01	0.530
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.949082e-01	0.530
Translation initiation complex formation	R-HSA-72649	3.134653e-01	0.504
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.322988e-01	0.478
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.856605e-01	0.544
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.246602e-01	0.648
RNA Polymerase III Transcription	R-HSA-74158	1.691193e-01	0.772
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.036044e-01	0.691
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.801487e-01	0.553
NGF-stimulated transcription	R-HSA-9031628	2.079449e-01	0.682
MET promotes cell motility	R-HSA-8875878	2.036044e-01	0.691
Neurodegenerative Diseases	R-HSA-8863678	2.207594e-01	0.656
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.207594e-01	0.656
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.001440e-01	0.699
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.207594e-01	0.656
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.036044e-01	0.691
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.519775e-01	0.599
Generation of second messenger molecules	R-HSA-202433	2.407687e-01	0.618
Platelet Adhesion to exposed collagen	R-HSA-75892	3.007024e-01	0.522
Extra-nuclear estrogen signaling	R-HSA-9009391	2.161933e-01	0.665
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.519775e-01	0.599
Degradation of DVL	R-HSA-4641258	1.860002e-01	0.730
Asymmetric localization of PCP proteins	R-HSA-4608870	2.505017e-01	0.601
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.292178e-01	0.640
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.106474e-01	0.508
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.937618e-01	0.532
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.938832e-01	0.532
Germ layer formation at gastrulation	R-HSA-9754189	2.002854e-01	0.698
MAPK1/MAPK3 signaling	R-HSA-5684996	3.263237e-01	0.486
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.762107e-01	0.754
Diseases of mitotic cell cycle	R-HSA-9675126	1.722132e-01	0.764
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.898438e-01	0.538
Regulation of Apoptosis	R-HSA-169911	2.496125e-01	0.603
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.096511e-01	0.679
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.881305e-01	0.540
RAF/MAP kinase cascade	R-HSA-5673001	2.697902e-01	0.569
PCP/CE pathway	R-HSA-4086400	2.434242e-01	0.614
TCF dependent signaling in response to WNT	R-HSA-201681	2.057336e-01	0.687
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	1.823538e-01	0.739
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.556276e-01	0.592
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.153624e-01	0.501
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.106474e-01	0.508
Apoptotic factor-mediated response	R-HSA-111471	3.211746e-01	0.493
Synaptic adhesion-like molecules	R-HSA-8849932	3.211746e-01	0.493
Orc1 removal from chromatin	R-HSA-68949	2.766765e-01	0.558
Meiosis	R-HSA-1500620	2.623980e-01	0.581
Cellular response to hypoxia	R-HSA-1234174	3.057864e-01	0.515
Signaling by WNT	R-HSA-195721	2.488379e-01	0.604
Synthesis of DNA	R-HSA-69239	1.715818e-01	0.766
Prolonged ERK activation events	R-HSA-169893	2.292178e-01	0.640
Stabilization of p53	R-HSA-69541	3.361718e-01	0.473
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.097690e-01	0.678
Platelet activation, signaling and aggregation	R-HSA-76002	2.027705e-01	0.693
DNA Replication Pre-Initiation	R-HSA-69002	3.302650e-01	0.481
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.236606e-01	0.650
Mismatch Repair	R-HSA-5358508	3.211746e-01	0.493
Reproduction	R-HSA-1474165	2.164622e-01	0.665
Signaling by NOTCH3	R-HSA-9012852	2.327850e-01	0.633
Signaling by NOTCH4	R-HSA-9013694	1.898799e-01	0.722
Interleukin-1 signaling	R-HSA-9020702	2.161933e-01	0.665
TNFR1-mediated ceramide production	R-HSA-5626978	2.556276e-01	0.592
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.153624e-01	0.501
Protein methylation	R-HSA-8876725	2.004242e-01	0.698
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.860002e-01	0.730
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.370280e-01	0.472
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.977713e-01	0.704
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.407687e-01	0.618
Regulation of TNFR1 signaling	R-HSA-5357905	1.766972e-01	0.753
Adaptive Immune System	R-HSA-1280218	1.966382e-01	0.706
TBC/RABGAPs	R-HSA-8854214	2.147851e-01	0.668
Gene Silencing by RNA	R-HSA-211000	3.034421e-01	0.518
TNF signaling	R-HSA-75893	2.491910e-01	0.603
C-type lectin receptors (CLRs)	R-HSA-5621481	2.011960e-01	0.696
Signaling by FGFR	R-HSA-190236	3.259544e-01	0.487
Signaling by FGFR2	R-HSA-5654738	2.722660e-01	0.565
CHL1 interactions	R-HSA-447041	2.237802e-01	0.650
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.729782e-01	0.762
Signalling to RAS	R-HSA-167044	2.519775e-01	0.599
HDACs deacetylate histones	R-HSA-3214815	3.322988e-01	0.478
Developmental Biology	R-HSA-1266738	1.982850e-01	0.703
Formation of paraxial mesoderm	R-HSA-9793380	3.366158e-01	0.473
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.153624e-01	0.501
Downstream signal transduction	R-HSA-186763	2.589397e-01	0.587
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.192363e-01	0.496
PLC beta mediated events	R-HSA-112043	2.401439e-01	0.620
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.560325e-01	0.592
HDMs demethylate histones	R-HSA-3214842	2.443941e-01	0.612
Activation of BH3-only proteins	R-HSA-114452	2.367461e-01	0.626
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	1.838697e-01	0.735
Formation of editosomes by ADAR proteins	R-HSA-77042	2.778697e-01	0.556
Inhibition of PKR	R-HSA-169131	2.778697e-01	0.556
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.961748e-01	0.707
Nectin/Necl trans heterodimerization	R-HSA-420597	3.153624e-01	0.501
Reelin signalling pathway	R-HSA-8866376	3.153624e-01	0.501
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.667935e-01	0.574
Co-stimulation by ICOS	R-HSA-9927354	2.667935e-01	0.574
Activation of RAC1	R-HSA-428540	2.299338e-01	0.638
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.760560e-01	0.754
The NLRP3 inflammasome	R-HSA-844456	2.002854e-01	0.698
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.106474e-01	0.508
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.007024e-01	0.522
Regulation of FZD by ubiquitination	R-HSA-4641263	2.898438e-01	0.538
MicroRNA (miRNA) biogenesis	R-HSA-203927	2.443941e-01	0.612
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.211746e-01	0.493
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.505017e-01	0.601
Viral Messenger RNA Synthesis	R-HSA-168325	2.401439e-01	0.620
Signaling by FGFR in disease	R-HSA-1226099	2.674525e-01	0.573
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.350270e-01	0.475
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.747058e-01	0.758
Smooth Muscle Contraction	R-HSA-445355	2.949082e-01	0.530
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.645358e-01	0.578
tRNA processing in the nucleus	R-HSA-6784531	2.560325e-01	0.592
Uptake and function of diphtheria toxin	R-HSA-5336415	2.237802e-01	0.650
Regulated proteolysis of p75NTR	R-HSA-193692	3.106474e-01	0.508
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.766972e-01	0.753
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.519775e-01	0.599
Mitochondrial biogenesis	R-HSA-1592230	1.798511e-01	0.745
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.937618e-01	0.532
Signaling by TGFBR3	R-HSA-9839373	2.691038e-01	0.570
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	2.648773e-01	0.577
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	2.648773e-01	0.577
Cellular response to mitochondrial stress	R-HSA-9840373	3.106474e-01	0.508
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.068408e-01	0.513
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.068408e-01	0.513
FLT3 signaling in disease	R-HSA-9682385	1.691193e-01	0.772
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.760560e-01	0.754
Regulation of HMOX1 expression and activity	R-HSA-9707587	2.556276e-01	0.592
VLDLR internalisation and degradation	R-HSA-8866427	2.648773e-01	0.577
Assembly Of The HIV Virion	R-HSA-175474	2.790999e-01	0.554
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.038187e-01	0.517
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.057864e-01	0.515
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.139496e-01	0.503
Growth hormone receptor signaling	R-HSA-982772	3.350270e-01	0.475
Leishmania phagocytosis	R-HSA-9664417	3.393126e-01	0.469
Parasite infection	R-HSA-9664407	3.393126e-01	0.469
FCGR3A-mediated phagocytosis	R-HSA-9664422	3.393126e-01	0.469
G-protein mediated events	R-HSA-112040	3.403319e-01	0.468
Cellular response to chemical stress	R-HSA-9711123	3.420956e-01	0.466
Activation of HOX genes during differentiation	R-HSA-5619507	3.421834e-01	0.466
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.421834e-01	0.466
RSV-host interactions	R-HSA-9833110	3.421834e-01	0.466
DAP12 interactions	R-HSA-2172127	3.422130e-01	0.466
Ca2+ pathway	R-HSA-4086398	3.435579e-01	0.464
Switching of origins to a post-replicative state	R-HSA-69052	3.435579e-01	0.464
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.526795e-01	0.453
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.526795e-01	0.453
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.526795e-01	0.453
Mitophagy	R-HSA-5205647	3.526795e-01	0.453
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.528606e-01	0.452
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.528606e-01	0.452
STING mediated induction of host immune responses	R-HSA-1834941	3.528606e-01	0.452
Formation of intermediate mesoderm	R-HSA-9761174	3.546839e-01	0.450
Signaling by Leptin	R-HSA-2586552	3.546839e-01	0.450
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.548867e-01	0.450
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.627631e-01	0.440
Deadenylation of mRNA	R-HSA-429947	3.634896e-01	0.440
Activation of NF-kappaB in B cells	R-HSA-1169091	3.673483e-01	0.435
Co-inhibition by PD-1	R-HSA-389948	3.679349e-01	0.434
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	3.711216e-01	0.430
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.711216e-01	0.430
Erythropoietin activates RAS	R-HSA-9027284	3.735010e-01	0.428
Beta-catenin phosphorylation cascade	R-HSA-196299	3.735010e-01	0.428
Processive synthesis on the lagging strand	R-HSA-69183	3.735010e-01	0.428
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	3.735010e-01	0.428
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	3.735010e-01	0.428
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.739535e-01	0.427
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.739535e-01	0.427
Noncanonical activation of NOTCH3	R-HSA-9017802	3.739535e-01	0.427
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.739535e-01	0.427
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.739535e-01	0.427
Proton/oligopeptide cotransporters	R-HSA-427975	3.739535e-01	0.427
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.739535e-01	0.427
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.768511e-01	0.424
Regulation of endogenous retroelements	R-HSA-9842860	3.840152e-01	0.416
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.846741e-01	0.415
VxPx cargo-targeting to cilium	R-HSA-5620916	3.846741e-01	0.415
Signaling by NODAL	R-HSA-1181150	3.846741e-01	0.415
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.848064e-01	0.415
Glucose metabolism	R-HSA-70326	3.861599e-01	0.413
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.863556e-01	0.413
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.863556e-01	0.413
Interactions of Tat with host cellular proteins	R-HSA-176034	3.863556e-01	0.413
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.863556e-01	0.413
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.863556e-01	0.413
PTEN Loss of Function in Cancer	R-HSA-5674404	3.863556e-01	0.413
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.863556e-01	0.413
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.863556e-01	0.413
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.863556e-01	0.413
Defective VWF binding to collagen type I	R-HSA-9845622	3.863556e-01	0.413
TRAF3 deficiency - HSE	R-HSA-5602571	3.863556e-01	0.413
IKBKB deficiency causes SCID	R-HSA-5602636	3.863556e-01	0.413
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.863556e-01	0.413
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.863556e-01	0.413
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.863556e-01	0.413
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.863556e-01	0.413
Signaling by TCF7L2 mutants	R-HSA-5339700	3.863556e-01	0.413
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.863556e-01	0.413
Manipulation of host energy metabolism	R-HSA-9636667	3.863556e-01	0.413
Inhibition of membrane repair	R-HSA-9635644	3.863556e-01	0.413
Breakdown of the nuclear lamina	R-HSA-352238	3.863556e-01	0.413
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.876421e-01	0.412
Transport to the Golgi and subsequent modification	R-HSA-948021	3.889540e-01	0.410
HCMV Early Events	R-HSA-9609690	3.889936e-01	0.410
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.899579e-01	0.409
Tight junction interactions	R-HSA-420029	3.920663e-01	0.407
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.920663e-01	0.407
Signaling by APC mutants	R-HSA-4839744	3.983388e-01	0.400
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.983388e-01	0.400
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.983388e-01	0.400
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.983388e-01	0.400
Signaling by ROBO receptors	R-HSA-376176	3.995434e-01	0.398
Vif-mediated degradation of APOBEC3G	R-HSA-180585	4.011193e-01	0.397
Degradation of CRY and PER proteins	R-HSA-9932298	4.040234e-01	0.394
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.062645e-01	0.391
Meiotic synapsis	R-HSA-1221632	4.080169e-01	0.389
Regulation of beta-cell development	R-HSA-186712	4.093982e-01	0.388
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.098017e-01	0.387
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.098017e-01	0.387
Killing mechanisms	R-HSA-9664420	4.098017e-01	0.387
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.098017e-01	0.387
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.098017e-01	0.387
Regulation of mitotic cell cycle	R-HSA-453276	4.113547e-01	0.386
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.113547e-01	0.386
Hedgehog 'on' state	R-HSA-5632684	4.113547e-01	0.386
NoRC negatively regulates rRNA expression	R-HSA-427413	4.113547e-01	0.386
Lagging Strand Synthesis	R-HSA-69186	4.164030e-01	0.380
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.164030e-01	0.380
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.206035e-01	0.376
Suppression of phagosomal maturation	R-HSA-9637687	4.206035e-01	0.376
SARS-CoV-1 Infection	R-HSA-9678108	4.232184e-01	0.373
TRAF6 mediated IRF7 activation	R-HSA-933541	4.253900e-01	0.371
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.259133e-01	0.371
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.292754e-01	0.367
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	4.303969e-01	0.366
Erythropoietin activates STAT5	R-HSA-9027283	4.303969e-01	0.366
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	4.303969e-01	0.366
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	4.303969e-01	0.366
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	4.303969e-01	0.366
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	4.303969e-01	0.366
Adipogenesis	R-HSA-9843745	4.399991e-01	0.357
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.411411e-01	0.355
Integration of provirus	R-HSA-162592	4.411411e-01	0.355
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.411411e-01	0.355
Signaling by AMER1 mutants	R-HSA-4839748	4.411411e-01	0.355
Signaling by AXIN mutants	R-HSA-4839735	4.411411e-01	0.355
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.456461e-01	0.351
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.456461e-01	0.351
RNA Polymerase I Transcription Termination	R-HSA-73863	4.489575e-01	0.348
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.489575e-01	0.348
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.491787e-01	0.348
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.491787e-01	0.348
G-protein beta:gamma signalling	R-HSA-397795	4.494508e-01	0.347
Integrin signaling	R-HSA-354192	4.494508e-01	0.347
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.494508e-01	0.347
Hh mutants abrogate ligand secretion	R-HSA-5387390	4.494567e-01	0.347
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.638802e-01	0.334
NCAM signaling for neurite out-growth	R-HSA-375165	4.677055e-01	0.330
Rab regulation of trafficking	R-HSA-9007101	4.703412e-01	0.328
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.710011e-01	0.327
Netrin-1 signaling	R-HSA-373752	4.720104e-01	0.326
RMTs methylate histone arginines	R-HSA-3214858	4.720104e-01	0.326
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.735843e-01	0.325
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.752430e-01	0.323
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.752430e-01	0.323
Effects of PIP2 hydrolysis	R-HSA-114508	4.752430e-01	0.323
Vpu mediated degradation of CD4	R-HSA-180534	4.752430e-01	0.323
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.760802e-01	0.322
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.769961e-01	0.321
Formation of the Early Elongation Complex	R-HSA-113418	4.769961e-01	0.321
Inflammasomes	R-HSA-622312	4.769961e-01	0.321
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.785489e-01	0.320
Defective ALG9 causes CDG-1l	R-HSA-4720454	4.785489e-01	0.320
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.785489e-01	0.320
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.785489e-01	0.320
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	4.785489e-01	0.320
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.785489e-01	0.320
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	4.785489e-01	0.320
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.785489e-01	0.320
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.785489e-01	0.320
Signaling by RAS GAP mutants	R-HSA-9753510	4.785489e-01	0.320
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	4.785489e-01	0.320
mRNA Editing: A to I Conversion	R-HSA-75064	4.785489e-01	0.320
Signalling to ERK5	R-HSA-198765	4.785489e-01	0.320
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.785489e-01	0.320
C6 deamination of adenosine	R-HSA-75102	4.785489e-01	0.320
Influenza Virus Induced Apoptosis	R-HSA-168277	4.785489e-01	0.320
DSCAM interactions	R-HSA-376172	4.785489e-01	0.320
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	4.788492e-01	0.320
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.788492e-01	0.320
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.807876e-01	0.318
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.807876e-01	0.318
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.807876e-01	0.318
Uptake and function of anthrax toxins	R-HSA-5210891	4.807876e-01	0.318
Glycogen storage diseases	R-HSA-3229121	4.807876e-01	0.318
Polymerase switching	R-HSA-69091	4.827085e-01	0.316
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.827085e-01	0.316
Leading Strand Synthesis	R-HSA-69109	4.827085e-01	0.316
Repression of WNT target genes	R-HSA-4641265	4.827085e-01	0.316
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.827085e-01	0.316
Signaling by LTK	R-HSA-9842663	4.827085e-01	0.316
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.840157e-01	0.315
MET activates PI3K/AKT signaling	R-HSA-8851907	4.840157e-01	0.315
Netrin mediated repulsion signals	R-HSA-418886	4.840157e-01	0.315
VLDL clearance	R-HSA-8964046	4.840157e-01	0.315
TRIF-mediated programmed cell death	R-HSA-2562578	4.840157e-01	0.315
PTK6 Expression	R-HSA-8849473	4.840157e-01	0.315
SLC-mediated transport of oligopeptides	R-HSA-9959399	4.840157e-01	0.315
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.840157e-01	0.315
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.892386e-01	0.310
Defective CFTR causes cystic fibrosis	R-HSA-5678895	4.943649e-01	0.306
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.943649e-01	0.306
Interleukin-12 family signaling	R-HSA-447115	4.958924e-01	0.305
HIV Transcription Elongation	R-HSA-167169	4.973435e-01	0.303
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.973435e-01	0.303
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.973435e-01	0.303
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.981860e-01	0.303
Interleukin-12 signaling	R-HSA-9020591	5.006355e-01	0.300
RAF activation	R-HSA-5673000	5.007094e-01	0.300
SARS-CoV Infections	R-HSA-9679506	5.040934e-01	0.297
Signaling by Erythropoietin	R-HSA-9006335	5.045994e-01	0.297
DARPP-32 events	R-HSA-180024	5.045994e-01	0.297
Insulin receptor signalling cascade	R-HSA-74751	5.061142e-01	0.296
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.092364e-01	0.293
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.092364e-01	0.293
DNA Replication	R-HSA-69306	5.128652e-01	0.290
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.148579e-01	0.288
PKA activation	R-HSA-163615	5.150164e-01	0.288
Tie2 Signaling	R-HSA-210993	5.150164e-01	0.288
Cytoprotection by HMOX1	R-HSA-9707564	5.151700e-01	0.288
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.164575e-01	0.287
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.207772e-01	0.283
Hh mutants are degraded by ERAD	R-HSA-5362768	5.207772e-01	0.283
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.207772e-01	0.283
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.227405e-01	0.282
Frs2-mediated activation	R-HSA-170968	5.227405e-01	0.282
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.316599e-01	0.274
Activated NTRK2 signals through PI3K	R-HSA-9028335	5.343849e-01	0.272
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	5.343849e-01	0.272
Adrenoceptors	R-HSA-390696	5.343849e-01	0.272
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.343849e-01	0.272
RSK activation	R-HSA-444257	5.343849e-01	0.272
Platelet degranulation	R-HSA-114608	5.374492e-01	0.270
Inositol phosphate metabolism	R-HSA-1483249	5.463080e-01	0.263
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.479473e-01	0.261
Specification of the neural plate border	R-HSA-9834899	5.481587e-01	0.261
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.481587e-01	0.261
Hemostasis	R-HSA-109582	5.491465e-01	0.260
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.537142e-01	0.257
MET activates STAT3	R-HSA-8875791	5.568956e-01	0.254
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.568956e-01	0.254
Axonal growth stimulation	R-HSA-209563	5.568956e-01	0.254
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	5.568956e-01	0.254
MET activates PTPN11	R-HSA-8865999	5.568956e-01	0.254
Invadopodia formation	R-HSA-8941237	5.568956e-01	0.254
Signalling to STAT3	R-HSA-198745	5.568956e-01	0.254
Classical Kir channels	R-HSA-1296053	5.568956e-01	0.254
Defective ABCC2 causes DJS	R-HSA-5679001	5.568956e-01	0.254
STAT6-mediated induction of chemokines	R-HSA-3249367	5.568956e-01	0.254
MET interacts with TNS proteins	R-HSA-8875513	5.568956e-01	0.254
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.568956e-01	0.254
Trafficking of AMPA receptors	R-HSA-399719	5.580828e-01	0.253
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.608172e-01	0.251
Signaling by FGFR4 in disease	R-HSA-5655291	5.610108e-01	0.251
HDL assembly	R-HSA-8963896	5.610108e-01	0.251
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.651132e-01	0.248
IRS-related events triggered by IGF1R	R-HSA-2428928	5.676612e-01	0.246
PI Metabolism	R-HSA-1483255	5.680830e-01	0.246
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.737297e-01	0.241
Degradation of AXIN	R-HSA-4641257	5.743174e-01	0.241
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.800746e-01	0.237
Glycogen synthesis	R-HSA-3322077	5.800746e-01	0.237
ARMS-mediated activation	R-HSA-170984	5.812705e-01	0.236
WNT mediated activation of DVL	R-HSA-201688	5.812705e-01	0.236
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.812705e-01	0.236
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	5.812705e-01	0.236
p75NTR regulates axonogenesis	R-HSA-193697	5.812705e-01	0.236
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.812705e-01	0.236
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	5.812705e-01	0.236
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.812705e-01	0.236
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.812705e-01	0.236
Respiratory syncytial virus genome replication	R-HSA-9834752	5.812705e-01	0.236
Interleukin-1 processing	R-HSA-448706	5.812705e-01	0.236
Butyrophilin (BTN) family interactions	R-HSA-8851680	5.812705e-01	0.236
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.865116e-01	0.232
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.920684e-01	0.228
Signaling by Insulin receptor	R-HSA-74752	5.921549e-01	0.228
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.954958e-01	0.225
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.973576e-01	0.224
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.973576e-01	0.224
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.973576e-01	0.224
Signaling by Activin	R-HSA-1502540	5.973576e-01	0.224
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.973576e-01	0.224
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.973576e-01	0.224
Formation of the anterior neural plate	R-HSA-9823739	5.973576e-01	0.224
Opioid Signalling	R-HSA-111885	5.974870e-01	0.224
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.982039e-01	0.223
PI3K Cascade	R-HSA-109704	6.011192e-01	0.221
Immune System	R-HSA-168256	6.017771e-01	0.221
Signaling by NOTCH	R-HSA-157118	6.020434e-01	0.220
rRNA modification in the nucleus and cytosol	R-HSA-6790901	6.049900e-01	0.218
Nuclear RNA decay	R-HSA-9930044	6.087008e-01	0.216
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.087008e-01	0.216
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	6.100068e-01	0.215
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.106558e-01	0.214
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	6.106558e-01	0.214
IRS-mediated signalling	R-HSA-112399	6.125682e-01	0.213
Signaling by ALK	R-HSA-201556	6.203815e-01	0.207
RAS processing	R-HSA-9648002	6.203815e-01	0.207
Plasma lipoprotein clearance	R-HSA-8964043	6.203815e-01	0.207
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.211282e-01	0.207
Hedgehog ligand biogenesis	R-HSA-5358346	6.211282e-01	0.207
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.222959e-01	0.206
IGF1R signaling cascade	R-HSA-2428924	6.230674e-01	0.205
PLCG1 events in ERBB2 signaling	R-HSA-1251932	6.234748e-01	0.205
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	6.234748e-01	0.205
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	6.234748e-01	0.205
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	6.234748e-01	0.205
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	6.234748e-01	0.205
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	6.234748e-01	0.205
Activation of NOXA and translocation to mitochondria	R-HSA-111448	6.234748e-01	0.205
NADE modulates death signalling	R-HSA-205025	6.234748e-01	0.205
Transmission across Electrical Synapses	R-HSA-112307	6.234748e-01	0.205
Electric Transmission Across Gap Junctions	R-HSA-112303	6.234748e-01	0.205
Dopamine receptors	R-HSA-390651	6.234748e-01	0.205
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	6.234748e-01	0.205
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.245823e-01	0.204
2-LTR circle formation	R-HSA-164843	6.245823e-01	0.204
Folding of actin by CCT/TriC	R-HSA-390450	6.245823e-01	0.204
EGFR Transactivation by Gastrin	R-HSA-2179392	6.245823e-01	0.204
DNA replication initiation	R-HSA-68952	6.245823e-01	0.204
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.245823e-01	0.204
Interleukin-27 signaling	R-HSA-9020956	6.245823e-01	0.204
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.245823e-01	0.204
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.309318e-01	0.200
Nucleosome assembly	R-HSA-774815	6.309318e-01	0.200
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.309318e-01	0.200
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.316757e-01	0.200
Phosphorylation of the APC/C	R-HSA-176412	6.316757e-01	0.200
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.316757e-01	0.200
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.316757e-01	0.200
Defective GALNT3 causes HFTC	R-HSA-5083625	6.316757e-01	0.200
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.316757e-01	0.200
Differentiation of T cells	R-HSA-9945266	6.316757e-01	0.200
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.316757e-01	0.200
Leishmania infection	R-HSA-9658195	6.327237e-01	0.199
Parasitic Infection Pathways	R-HSA-9824443	6.327237e-01	0.199
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.327691e-01	0.199
Muscle contraction	R-HSA-397014	6.359009e-01	0.197
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.398227e-01	0.194
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.398227e-01	0.194
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.406003e-01	0.193
Uptake and actions of bacterial toxins	R-HSA-5339562	6.406003e-01	0.193
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.407176e-01	0.193
G alpha (12/13) signalling events	R-HSA-416482	6.418484e-01	0.193
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.423523e-01	0.192
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.423523e-01	0.192
Deadenylation-dependent mRNA decay	R-HSA-429914	6.495555e-01	0.187
Protein-protein interactions at synapses	R-HSA-6794362	6.503511e-01	0.187
Regulation of pyruvate metabolism	R-HSA-9861718	6.512238e-01	0.186
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.559451e-01	0.183
G beta:gamma signalling through CDC42	R-HSA-8964616	6.639078e-01	0.178
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.639078e-01	0.178
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.639078e-01	0.178
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.639078e-01	0.178
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	6.643357e-01	0.178
Formation of the posterior neural plate	R-HSA-9832991	6.643357e-01	0.178
RHOBTB3 ATPase cycle	R-HSA-9706019	6.643357e-01	0.178
Bicarbonate transporters	R-HSA-425381	6.643357e-01	0.178
CD163 mediating an anti-inflammatory response	R-HSA-9662834	6.643357e-01	0.178
Dissolution of Fibrin Clot	R-HSA-75205	6.643357e-01	0.178
PI-3K cascade:FGFR1	R-HSA-5654689	6.675218e-01	0.176
FGFR2 alternative splicing	R-HSA-6803529	6.675218e-01	0.176
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.675218e-01	0.176
mRNA Capping	R-HSA-72086	6.725808e-01	0.172
Regulation of gene expression in beta cells	R-HSA-210745	6.725808e-01	0.172
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.751795e-01	0.171
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.751795e-01	0.171
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.751795e-01	0.171
PERK regulates gene expression	R-HSA-381042	6.781939e-01	0.169
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.797117e-01	0.168
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.800532e-01	0.167
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.800532e-01	0.167
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	6.800532e-01	0.167
NOSIP mediated eNOS trafficking	R-HSA-203754	6.800532e-01	0.167
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.800532e-01	0.167
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.800532e-01	0.167
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.800532e-01	0.167
PTK6 Activates STAT3	R-HSA-8849474	6.800532e-01	0.167
Activation of AKT2	R-HSA-165158	6.800532e-01	0.167
Muscarinic acetylcholine receptors	R-HSA-390648	6.800532e-01	0.167
Inositol transporters	R-HSA-429593	6.800532e-01	0.167
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	6.800532e-01	0.167
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	6.800532e-01	0.167
Assembly of Viral Components at the Budding Site	R-HSA-168316	6.800532e-01	0.167
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.839905e-01	0.165
Intra-Golgi traffic	R-HSA-6811438	6.839905e-01	0.165
Translation of Structural Proteins	R-HSA-9683701	6.839905e-01	0.165
Neutrophil degranulation	R-HSA-6798695	6.848660e-01	0.164
Regulated Necrosis	R-HSA-5218859	6.908925e-01	0.161
Chromosome Maintenance	R-HSA-73886	6.929257e-01	0.159
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.937225e-01	0.159
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.937225e-01	0.159
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.937225e-01	0.159
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.940363e-01	0.159
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.940363e-01	0.159
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.940363e-01	0.159
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.940363e-01	0.159
Iron uptake and transport	R-HSA-917937	6.970326e-01	0.157
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.970326e-01	0.157
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.975533e-01	0.156
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.006220e-01	0.155
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.006220e-01	0.155
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.006220e-01	0.155
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.006220e-01	0.155
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.006220e-01	0.155
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.006220e-01	0.155
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	7.006220e-01	0.155
Signaling by PDGF	R-HSA-186797	7.011529e-01	0.154
RNA Polymerase I Promoter Clearance	R-HSA-73854	7.119764e-01	0.148
Ion homeostasis	R-HSA-5578775	7.126186e-01	0.147
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.164807e-01	0.145
Molecules associated with elastic fibres	R-HSA-2129379	7.182255e-01	0.144
Plasma lipoprotein assembly	R-HSA-8963898	7.184140e-01	0.144
ABC-family proteins mediated transport	R-HSA-382556	7.193975e-01	0.143
SARS-CoV-2 Infection	R-HSA-9694516	7.196464e-01	0.143
RNA Polymerase III Transcription Termination	R-HSA-73980	7.220764e-01	0.141
PKA activation in glucagon signalling	R-HSA-164378	7.220764e-01	0.141
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.220764e-01	0.141
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.264508e-01	0.139
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.281327e-01	0.138
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	7.281327e-01	0.138
Plus-strand DNA synthesis	R-HSA-164525	7.281327e-01	0.138
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	7.281327e-01	0.138
PTK6 Regulates Cell Cycle	R-HSA-8849470	7.281327e-01	0.138
Signaling by MAPK mutants	R-HSA-9652817	7.281327e-01	0.138
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	7.281327e-01	0.138
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	7.281327e-01	0.138
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.281327e-01	0.138
PDE3B signalling	R-HSA-165160	7.281327e-01	0.138
PKB-mediated events	R-HSA-109703	7.281327e-01	0.138
CDC6 association with the ORC:origin complex	R-HSA-68689	7.281327e-01	0.138
CLEC7A/inflammasome pathway	R-HSA-5660668	7.281327e-01	0.138
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	7.281327e-01	0.138
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.335855e-01	0.135
Interleukin-35 Signalling	R-HSA-8984722	7.335855e-01	0.135
OAS antiviral response	R-HSA-8983711	7.335855e-01	0.135
Signaling by WNT in cancer	R-HSA-4791275	7.392750e-01	0.131
RNA Polymerase I Transcription	R-HSA-73864	7.404490e-01	0.131
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.416030e-01	0.130
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.416030e-01	0.130
Acyl chain remodelling of PS	R-HSA-1482801	7.416030e-01	0.130
Meiotic recombination	R-HSA-912446	7.423683e-01	0.129
HCMV Infection	R-HSA-9609646	7.463732e-01	0.127
E2F mediated regulation of DNA replication	R-HSA-113510	7.480695e-01	0.126
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.480695e-01	0.126
Other interleukin signaling	R-HSA-449836	7.480695e-01	0.126
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.572398e-01	0.121
Somitogenesis	R-HSA-9824272	7.575012e-01	0.121
Cardiogenesis	R-HSA-9733709	7.591473e-01	0.120
Transmission across Chemical Synapses	R-HSA-112315	7.613065e-01	0.118
MET activates PTK2 signaling	R-HSA-8874081	7.633105e-01	0.117
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.633105e-01	0.117
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.633105e-01	0.117
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	7.634053e-01	0.117
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.634053e-01	0.117
Interleukin-6 signaling	R-HSA-1059683	7.634053e-01	0.117
Maturation of nucleoprotein	R-HSA-9683610	7.634053e-01	0.117
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.634053e-01	0.117
VLDL assembly	R-HSA-8866423	7.689894e-01	0.114
Chylomicron clearance	R-HSA-8964026	7.689894e-01	0.114
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	7.689894e-01	0.114
Uncoating of the HIV Virion	R-HSA-162585	7.689894e-01	0.114
Autointegration results in viral DNA circles	R-HSA-177539	7.689894e-01	0.114
Defective CHST6 causes MCDC1	R-HSA-3656225	7.689894e-01	0.114
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	7.689894e-01	0.114
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	7.689894e-01	0.114
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	7.689894e-01	0.114
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.689894e-01	0.114
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	7.689894e-01	0.114
G2/M DNA replication checkpoint	R-HSA-69478	7.689894e-01	0.114
Integration of viral DNA into host genomic DNA	R-HSA-175567	7.689894e-01	0.114
HDL clearance	R-HSA-8964011	7.689894e-01	0.114
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.695261e-01	0.114
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.737943e-01	0.111
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.749575e-01	0.111
Diseases of Immune System	R-HSA-5260271	7.749575e-01	0.111
Glycogen metabolism	R-HSA-8982491	7.749575e-01	0.111
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.778574e-01	0.109
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.835695e-01	0.106
Signaling by BMP	R-HSA-201451	7.835695e-01	0.106
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.835695e-01	0.106
Insulin processing	R-HSA-264876	7.835695e-01	0.106
Assembly of the pre-replicative complex	R-HSA-68867	7.840462e-01	0.106
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.902816e-01	0.102
Zinc transporters	R-HSA-435354	7.902816e-01	0.102
Signal regulatory protein family interactions	R-HSA-391160	7.902816e-01	0.102
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.915188e-01	0.102
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.915188e-01	0.102
Early Phase of HIV Life Cycle	R-HSA-162594	7.941782e-01	0.100
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.941782e-01	0.100
Basigin interactions	R-HSA-210991	7.941782e-01	0.100
Zygotic genome activation (ZGA)	R-HSA-9819196	7.941782e-01	0.100
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.954280e-01	0.099
Calnexin/calreticulin cycle	R-HSA-901042	7.954280e-01	0.099
Pre-NOTCH Expression and Processing	R-HSA-1912422	8.014845e-01	0.096
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.016804e-01	0.096
Insulin receptor recycling	R-HSA-77387	8.024228e-01	0.096
Phase 0 - rapid depolarisation	R-HSA-5576892	8.024228e-01	0.096
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.024228e-01	0.096
NOSTRIN mediated eNOS trafficking	R-HSA-203641	8.037081e-01	0.095
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	8.037081e-01	0.095
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	8.037081e-01	0.095
Disinhibition of SNARE formation	R-HSA-114516	8.037081e-01	0.095
DAG1 core M1 glycosylations	R-HSA-8932506	8.037081e-01	0.095
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	8.037081e-01	0.095
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	8.037081e-01	0.095
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	8.037081e-01	0.095
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.037081e-01	0.095
Phase 3 - rapid repolarisation	R-HSA-5576890	8.037081e-01	0.095
LDL remodeling	R-HSA-8964041	8.037081e-01	0.095
Opsins	R-HSA-419771	8.037081e-01	0.095
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	8.037081e-01	0.095
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	8.037081e-01	0.095
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	8.037081e-01	0.095
Nef Mediated CD4 Down-regulation	R-HSA-167590	8.037081e-01	0.095
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.069256e-01	0.093
PPARA activates gene expression	R-HSA-1989781	8.096240e-01	0.092
Downstream signaling of activated FGFR1	R-HSA-5654687	8.118882e-01	0.091
Transferrin endocytosis and recycling	R-HSA-917977	8.118882e-01	0.091
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.144257e-01	0.089
RNA Polymerase III Chain Elongation	R-HSA-73780	8.144257e-01	0.089
G beta:gamma signalling through BTK	R-HSA-8964315	8.144257e-01	0.089
Lysosphingolipid and LPA receptors	R-HSA-419408	8.144257e-01	0.089
Biotin transport and metabolism	R-HSA-196780	8.144257e-01	0.089
DNA Damage Reversal	R-HSA-73942	8.144257e-01	0.089
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.144600e-01	0.089
Attachment and Entry	R-HSA-9694614	8.144600e-01	0.089
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.144600e-01	0.089
Base Excision Repair	R-HSA-73884	8.151058e-01	0.089
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.178291e-01	0.087
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.215251e-01	0.085
Integrin cell surface interactions	R-HSA-216083	8.248801e-01	0.084
Ion transport by P-type ATPases	R-HSA-936837	8.262871e-01	0.083
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.330196e-01	0.079
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.330196e-01	0.079
Reverse Transcription of HIV RNA	R-HSA-162589	8.332106e-01	0.079
Minus-strand DNA synthesis	R-HSA-164516	8.332106e-01	0.079
DAG1 core M2 glycosylations	R-HSA-8932504	8.332106e-01	0.079
FGFR1b ligand binding and activation	R-HSA-190370	8.332106e-01	0.079
Signaling by MRAS-complex mutants	R-HSA-9660537	8.332106e-01	0.079
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.332106e-01	0.079
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.332106e-01	0.079
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.332106e-01	0.079
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	8.332106e-01	0.079
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.332106e-01	0.079
Interleukin-23 signaling	R-HSA-9020933	8.332106e-01	0.079
Activation of RAS in B cells	R-HSA-1169092	8.332106e-01	0.079
Interleukin-9 signaling	R-HSA-8985947	8.332106e-01	0.079
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.332106e-01	0.079
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.332106e-01	0.079
phospho-PLA2 pathway	R-HSA-111995	8.332106e-01	0.079
TGFBR3 PTM regulation	R-HSA-9839383	8.332106e-01	0.079
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	8.332106e-01	0.079
Class I peroxisomal membrane protein import	R-HSA-9603798	8.360514e-01	0.078
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.360514e-01	0.078
Induction of Cell-Cell Fusion	R-HSA-9733458	8.360514e-01	0.078
Attachment and Entry	R-HSA-9678110	8.360514e-01	0.078
Activation of SMO	R-HSA-5635838	8.360514e-01	0.078
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.361201e-01	0.078
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.362391e-01	0.078
Interferon alpha/beta signaling	R-HSA-909733	8.379486e-01	0.077
Post-translational protein phosphorylation	R-HSA-8957275	8.446304e-01	0.073
Cap-dependent Translation Initiation	R-HSA-72737	8.462316e-01	0.073
Eukaryotic Translation Initiation	R-HSA-72613	8.462316e-01	0.073
Termination of O-glycan biosynthesis	R-HSA-977068	8.499581e-01	0.071
Interleukin receptor SHC signaling	R-HSA-912526	8.499581e-01	0.071
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.510811e-01	0.070
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.510811e-01	0.070
Peroxisomal protein import	R-HSA-9033241	8.511264e-01	0.070
Extension of Telomeres	R-HSA-180786	8.511264e-01	0.070
FCERI mediated MAPK activation	R-HSA-2871796	8.537018e-01	0.069
Elastic fibre formation	R-HSA-1566948	8.549682e-01	0.068
tRNA modification in the mitochondrion	R-HSA-6787450	8.553704e-01	0.068
Acetylcholine regulates insulin secretion	R-HSA-399997	8.553704e-01	0.068
MAPK1 (ERK2) activation	R-HSA-112411	8.582804e-01	0.066
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.582804e-01	0.066
Interleukin-21 signaling	R-HSA-9020958	8.582804e-01	0.066
mRNA Editing	R-HSA-75072	8.582804e-01	0.066
Regulation of signaling by NODAL	R-HSA-1433617	8.582804e-01	0.066
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.582804e-01	0.066
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.582804e-01	0.066
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.582804e-01	0.066
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.601029e-01	0.065
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.648671e-01	0.063
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.653788e-01	0.063
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.653788e-01	0.063
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.653788e-01	0.063
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.653788e-01	0.063
TNFs bind their physiological receptors	R-HSA-5669034	8.653788e-01	0.063
Developmental Cell Lineages	R-HSA-9734767	8.711754e-01	0.060
ER-Phagosome pathway	R-HSA-1236974	8.713156e-01	0.060
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.713255e-01	0.060
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.713255e-01	0.060
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.725873e-01	0.059
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.725873e-01	0.059
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.727899e-01	0.059
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.759972e-01	0.057
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.766056e-01	0.057
Antigen processing-Cross presentation	R-HSA-1236975	8.766056e-01	0.057
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.775434e-01	0.057
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.788569e-01	0.056
Interleukin-2 family signaling	R-HSA-451927	8.788569e-01	0.056
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.793854e-01	0.056
Activation of G protein gated Potassium channels	R-HSA-1296041	8.793854e-01	0.056
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.793854e-01	0.056
G protein gated Potassium channels	R-HSA-1296059	8.793854e-01	0.056
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.793854e-01	0.056
Formation of the nephric duct	R-HSA-9830364	8.793854e-01	0.056
Binding and entry of HIV virion	R-HSA-173107	8.795831e-01	0.056
Apoptosis induced DNA fragmentation	R-HSA-140342	8.795831e-01	0.056
MAPK3 (ERK1) activation	R-HSA-110056	8.795831e-01	0.056
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.795831e-01	0.056
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.795831e-01	0.056
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.795831e-01	0.056
Receptor Mediated Mitophagy	R-HSA-8934903	8.795831e-01	0.056
Maturation of spike protein	R-HSA-9683686	8.795831e-01	0.056
COPII-mediated vesicle transport	R-HSA-204005	8.860721e-01	0.053
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.878976e-01	0.052
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.878976e-01	0.052
FGFR1 ligand binding and activation	R-HSA-190242	8.878976e-01	0.052
Glucagon signaling in metabolic regulation	R-HSA-163359	8.891754e-01	0.051
ABC transporter disorders	R-HSA-5619084	8.911279e-01	0.050
TRP channels	R-HSA-3295583	8.920801e-01	0.050
Sphingolipid catabolism	R-HSA-9845614	8.920801e-01	0.050
Chylomicron assembly	R-HSA-8963888	8.976848e-01	0.047
DAG1 core M3 glycosylations	R-HSA-8932505	8.976848e-01	0.047
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.976848e-01	0.047
vRNA Synthesis	R-HSA-192814	8.976848e-01	0.047
vRNP Assembly	R-HSA-192905	8.976848e-01	0.047
Synthesis of PI	R-HSA-1483226	8.976848e-01	0.047
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.976848e-01	0.047
Activated NTRK3 signals through RAS	R-HSA-9034864	8.976848e-01	0.047
Vitamin B1 (thiamin) metabolism	R-HSA-196819	8.976848e-01	0.047
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.976848e-01	0.047
Prostanoid ligand receptors	R-HSA-391908	8.976848e-01	0.047
Interleukin-2 signaling	R-HSA-9020558	8.976848e-01	0.047
PI-3K cascade:FGFR3	R-HSA-5654710	9.014852e-01	0.045
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.014852e-01	0.045
Maturation of nucleoprotein	R-HSA-9694631	9.014852e-01	0.045
Signaling by FGFR3 in disease	R-HSA-5655332	9.035624e-01	0.044
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.073280e-01	0.042
Signaling by FGFR2 in disease	R-HSA-5655253	9.089489e-01	0.041
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.103960e-01	0.041
Scavenging by Class H Receptors	R-HSA-3000497	9.130662e-01	0.039
Synthesis of diphthamide-EEF2	R-HSA-5358493	9.130662e-01	0.039
Plasmalogen biosynthesis	R-HSA-75896	9.130662e-01	0.039
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	9.130662e-01	0.039
Anchoring fibril formation	R-HSA-2214320	9.130662e-01	0.039
Endosomal/Vacuolar pathway	R-HSA-1236977	9.130662e-01	0.039
Activated NTRK2 signals through RAS	R-HSA-9026519	9.130662e-01	0.039
PI-3K cascade:FGFR4	R-HSA-5654720	9.135220e-01	0.039
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.135220e-01	0.039
Protein hydroxylation	R-HSA-9629569	9.135220e-01	0.039
Pyrimidine salvage	R-HSA-73614	9.139283e-01	0.039
Glycosphingolipid transport	R-HSA-9845576	9.184549e-01	0.037
Triglyceride catabolism	R-HSA-163560	9.184549e-01	0.037
Influenza Infection	R-HSA-168255	9.191947e-01	0.037
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.194528e-01	0.036
Viral Infection Pathways	R-HSA-9824446	9.198693e-01	0.036
Downstream signaling of activated FGFR3	R-HSA-5654708	9.232696e-01	0.035
Platelet calcium homeostasis	R-HSA-418360	9.232696e-01	0.035
RNA Polymerase I Promoter Escape	R-HSA-73772	9.238991e-01	0.034
Neurexins and neuroligins	R-HSA-6794361	9.238991e-01	0.034
Innate Immune System	R-HSA-168249	9.246002e-01	0.034
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.246013e-01	0.034
Maple Syrup Urine Disease	R-HSA-9865114	9.261360e-01	0.033
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	9.261360e-01	0.033
Defective EXT2 causes exostoses 2	R-HSA-3656237	9.261360e-01	0.033
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.261360e-01	0.033
Role of second messengers in netrin-1 signaling	R-HSA-418890	9.261360e-01	0.033
Proline catabolism	R-HSA-70688	9.261360e-01	0.033
GRB2 events in EGFR signaling	R-HSA-179812	9.261360e-01	0.033
MET activates RAS signaling	R-HSA-8851805	9.261360e-01	0.033
Interleukin-15 signaling	R-HSA-8983432	9.261360e-01	0.033
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.261360e-01	0.033
SHC-related events triggered by IGF1R	R-HSA-2428933	9.261360e-01	0.033
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.261360e-01	0.033
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	9.261360e-01	0.033
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	9.261360e-01	0.033
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.313664e-01	0.031
Downstream signaling of activated FGFR4	R-HSA-5654716	9.316734e-01	0.031
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.316734e-01	0.031
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.316734e-01	0.031
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.321629e-01	0.031
Mitochondrial calcium ion transport	R-HSA-8949215	9.335670e-01	0.030
Telomere Maintenance	R-HSA-157579	9.345317e-01	0.029
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	9.372415e-01	0.028
Chylomicron remodeling	R-HSA-8963901	9.372415e-01	0.028
FGFR1c ligand binding and activation	R-HSA-190373	9.372415e-01	0.028
Processing of SMDT1	R-HSA-8949664	9.372415e-01	0.028
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	9.372415e-01	0.028
Condensation of Prophase Chromosomes	R-HSA-2299718	9.378021e-01	0.028
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.406051e-01	0.027
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.406051e-01	0.027
Pentose phosphate pathway	R-HSA-71336	9.406051e-01	0.027
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.406051e-01	0.027
Eukaryotic Translation Elongation	R-HSA-156842	9.415038e-01	0.026
RAF-independent MAPK1/3 activation	R-HSA-112409	9.418552e-01	0.026
Neurotoxicity of clostridium toxins	R-HSA-168799	9.418552e-01	0.026
LDL clearance	R-HSA-8964038	9.418552e-01	0.026
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.418552e-01	0.026
G alpha (z) signalling events	R-HSA-418597	9.422817e-01	0.026
ECM proteoglycans	R-HSA-3000178	9.422864e-01	0.026
Inwardly rectifying K+ channels	R-HSA-1296065	9.459912e-01	0.024
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.459912e-01	0.024
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.466709e-01	0.024
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	9.466778e-01	0.024
Synthesis of IPs in the nucleus	R-HSA-1855191	9.466778e-01	0.024
cGMP effects	R-HSA-418457	9.466778e-01	0.024
Prolactin receptor signaling	R-HSA-1170546	9.466778e-01	0.024
Physiological factors	R-HSA-5578768	9.466778e-01	0.024
Glycerophospholipid catabolism	R-HSA-6814848	9.466778e-01	0.024
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.466778e-01	0.024
Malate-aspartate shuttle	R-HSA-9856872	9.466778e-01	0.024
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.476838e-01	0.023
Neuronal System	R-HSA-112316	9.490047e-01	0.023
GPER1 signaling	R-HSA-9634597	9.490702e-01	0.023
Gluconeogenesis	R-HSA-70263	9.490702e-01	0.023
Interleukin-20 family signaling	R-HSA-8854691	9.491535e-01	0.023
Formation of the ureteric bud	R-HSA-9830674	9.491535e-01	0.023
ABC transporters in lipid homeostasis	R-HSA-1369062	9.491535e-01	0.023
Carnitine shuttle	R-HSA-200425	9.491535e-01	0.023
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.500467e-01	0.022
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.525168e-01	0.021
SHC1 events in EGFR signaling	R-HSA-180336	9.546958e-01	0.020
Other semaphorin interactions	R-HSA-416700	9.546958e-01	0.020
Interleukin-6 family signaling	R-HSA-6783589	9.555722e-01	0.020
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.555722e-01	0.020
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.565885e-01	0.019
Scavenging by Class A Receptors	R-HSA-3000480	9.571323e-01	0.019
Acyl chain remodelling of PC	R-HSA-1482788	9.574757e-01	0.019
Miscellaneous transport and binding events	R-HSA-5223345	9.574757e-01	0.019
Amino acid transport across the plasma membrane	R-HSA-352230	9.605901e-01	0.017
PI-3K cascade:FGFR2	R-HSA-5654695	9.612107e-01	0.017
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.612107e-01	0.017
Laminin interactions	R-HSA-3000157	9.612107e-01	0.017
Integration of energy metabolism	R-HSA-163685	9.614031e-01	0.017
Phase 4 - resting membrane potential	R-HSA-5576886	9.615085e-01	0.017
Activation of the phototransduction cascade	R-HSA-2485179	9.615085e-01	0.017
Fructose catabolism	R-HSA-70350	9.615085e-01	0.017
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.615085e-01	0.017
Atorvastatin ADME	R-HSA-9754706	9.615085e-01	0.017
Virus Assembly and Release	R-HSA-168268	9.615085e-01	0.017
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.623184e-01	0.017
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.623184e-01	0.017
Signal amplification	R-HSA-392518	9.623184e-01	0.017
eNOS activation	R-HSA-203615	9.623184e-01	0.017
FCERI mediated NF-kB activation	R-HSA-2871837	9.651916e-01	0.015
Translation of Structural Proteins	R-HSA-9694635	9.657298e-01	0.015
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.661585e-01	0.015
Ribosome-associated quality control	R-HSA-9948299	9.662730e-01	0.015
Downstream signaling of activated FGFR2	R-HSA-5654696	9.666386e-01	0.015
Acyl chain remodelling of PE	R-HSA-1482839	9.666386e-01	0.015
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.672970e-01	0.014
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.672970e-01	0.014
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.672970e-01	0.014
Scavenging by Class B Receptors	R-HSA-3000471	9.672970e-01	0.014
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.672970e-01	0.014
Phase 2 - plateau phase	R-HSA-5576893	9.672970e-01	0.014
Passive transport by Aquaporins	R-HSA-432047	9.672970e-01	0.014
Fibronectin matrix formation	R-HSA-1566977	9.672970e-01	0.014
Synthesis of PG	R-HSA-1483148	9.672970e-01	0.014
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.672970e-01	0.014
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.683500e-01	0.014
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.683500e-01	0.014
Ion channel transport	R-HSA-983712	9.689376e-01	0.014
Proteasome assembly	R-HSA-9907900	9.693153e-01	0.014
Amine ligand-binding receptors	R-HSA-375280	9.693153e-01	0.014
Amino acids regulate mTORC1	R-HSA-9639288	9.695898e-01	0.013
Lysosome Vesicle Biogenesis	R-HSA-432720	9.704880e-01	0.013
FGFR2 mutant receptor activation	R-HSA-1839126	9.704880e-01	0.013
Cristae formation	R-HSA-8949613	9.704958e-01	0.013
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.704958e-01	0.013
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.722154e-01	0.012
Catecholamine biosynthesis	R-HSA-209905	9.722154e-01	0.012
Pyruvate metabolism	R-HSA-70268	9.734056e-01	0.012
Stimuli-sensing channels	R-HSA-2672351	9.735202e-01	0.012
tRNA processing	R-HSA-72306	9.743786e-01	0.011
Paracetamol ADME	R-HSA-9753281	9.754032e-01	0.011
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.755496e-01	0.011
Diseases of programmed cell death	R-HSA-9645723	9.756467e-01	0.011
G beta:gamma signalling through PLC beta	R-HSA-418217	9.763942e-01	0.010
Presynaptic function of Kainate receptors	R-HSA-500657	9.763942e-01	0.010
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	9.763942e-01	0.010
Nephron development	R-HSA-9831926	9.763942e-01	0.010
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.769603e-01	0.010
Cell surface interactions at the vascular wall	R-HSA-202733	9.773472e-01	0.010
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.776178e-01	0.010
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.776178e-01	0.010
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.779048e-01	0.010
Interferon gamma signaling	R-HSA-877300	9.790099e-01	0.009
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.791583e-01	0.009
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.796658e-01	0.009
Crosslinking of collagen fibrils	R-HSA-2243919	9.799448e-01	0.009
Pyrimidine biosynthesis	R-HSA-500753	9.799448e-01	0.009
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.799448e-01	0.009
Diseases of hemostasis	R-HSA-9671793	9.799448e-01	0.009
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.799448e-01	0.009
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.799448e-01	0.009
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.799448e-01	0.009
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.799448e-01	0.009
Dectin-2 family	R-HSA-5621480	9.801670e-01	0.009
SLC-mediated transport of amino acids	R-HSA-9958863	9.823357e-01	0.008
Kidney development	R-HSA-9830369	9.823357e-01	0.008
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.829615e-01	0.007
Keratan sulfate degradation	R-HSA-2022857	9.829615e-01	0.007
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.829615e-01	0.007
Creatine metabolism	R-HSA-71288	9.829615e-01	0.007
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.829615e-01	0.007
Eicosanoid ligand-binding receptors	R-HSA-391903	9.829615e-01	0.007
Cargo concentration in the ER	R-HSA-5694530	9.830614e-01	0.007
Platelet homeostasis	R-HSA-418346	9.838263e-01	0.007
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.840554e-01	0.007
Triglyceride metabolism	R-HSA-8979227	9.840554e-01	0.007
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.841947e-01	0.007
Azathioprine ADME	R-HSA-9748787	9.846182e-01	0.007
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.849980e-01	0.007
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.855246e-01	0.006
G-protein activation	R-HSA-202040	9.855246e-01	0.006
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.855246e-01	0.006
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.855246e-01	0.006
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.855246e-01	0.006
Acyl chain remodelling of PG	R-HSA-1482925	9.855246e-01	0.006
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.855246e-01	0.006
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.855246e-01	0.006
RAB geranylgeranylation	R-HSA-8873719	9.857188e-01	0.006
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.857188e-01	0.006
Glutathione conjugation	R-HSA-156590	9.857188e-01	0.006
FCGR activation	R-HSA-2029481	9.858372e-01	0.006
The phototransduction cascade	R-HSA-2514856	9.863256e-01	0.006
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.870829e-01	0.006
Aquaporin-mediated transport	R-HSA-445717	9.872174e-01	0.006
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.877022e-01	0.005
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.877022e-01	0.005
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.877022e-01	0.005
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.877022e-01	0.005
Serine metabolism	R-HSA-977347	9.877022e-01	0.005
Glutathione synthesis and recycling	R-HSA-174403	9.877022e-01	0.005
GABA B receptor activation	R-HSA-977444	9.877476e-01	0.005
Activation of GABAB receptors	R-HSA-991365	9.877476e-01	0.005
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.877476e-01	0.005
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.885183e-01	0.005
Cardiac conduction	R-HSA-5576891	9.891589e-01	0.005
Protein localization	R-HSA-9609507	9.893560e-01	0.005
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.895524e-01	0.005
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.895524e-01	0.005
Fructose metabolism	R-HSA-5652084	9.895524e-01	0.005
Ethanol oxidation	R-HSA-71384	9.895524e-01	0.005
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.895524e-01	0.005
Cellular hexose transport	R-HSA-189200	9.895524e-01	0.005
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.903606e-01	0.004
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.903606e-01	0.004
Biosynthesis of maresins	R-HSA-9018682	9.911242e-01	0.004
Organic anion transport by SLCO transporters	R-HSA-879518	9.911242e-01	0.004
ROS and RNS production in phagocytes	R-HSA-1222556	9.915679e-01	0.004
Regulation of insulin secretion	R-HSA-422356	9.919441e-01	0.004
CYP2E1 reactions	R-HSA-211999	9.924597e-01	0.003
Thromboxane signalling through TP receptor	R-HSA-428930	9.924597e-01	0.003
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.924686e-01	0.003
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.927278e-01	0.003
PRC2 methylates histones and DNA	R-HSA-212300	9.927489e-01	0.003
HS-GAG biosynthesis	R-HSA-2022928	9.927489e-01	0.003
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.928802e-01	0.003
Leishmania parasite growth and survival	R-HSA-9664433	9.928802e-01	0.003
Synthesis of PA	R-HSA-1483166	9.933408e-01	0.003
Hyaluronan degradation	R-HSA-2160916	9.935943e-01	0.003
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.937151e-01	0.003
Voltage gated Potassium channels	R-HSA-1296072	9.937151e-01	0.003
SLC-mediated transport of organic cations	R-HSA-549127	9.937151e-01	0.003
Collagen chain trimerization	R-HSA-8948216	9.937151e-01	0.003
Metabolism of folate and pterines	R-HSA-196757	9.937151e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.938902e-01	0.003
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.945582e-01	0.002
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.945582e-01	0.002
Linoleic acid (LA) metabolism	R-HSA-2046105	9.945582e-01	0.002
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.945582e-01	0.002
Urea cycle	R-HSA-70635	9.945582e-01	0.002
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.949680e-01	0.002
rRNA processing	R-HSA-72312	9.952925e-01	0.002
RNA Polymerase I Promoter Opening	R-HSA-73728	9.953772e-01	0.002
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.953772e-01	0.002
Triglyceride biosynthesis	R-HSA-75109	9.953772e-01	0.002
Maturation of hRSV A proteins	R-HSA-9828806	9.953772e-01	0.002
Formation of a pool of free 40S subunits	R-HSA-72689	9.954567e-01	0.002
Peptide chain elongation	R-HSA-156902	9.954879e-01	0.002
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.959239e-01	0.002
Telomere Extension By Telomerase	R-HSA-171319	9.960729e-01	0.002
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.960729e-01	0.002
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.960729e-01	0.002
Pyroptosis	R-HSA-5620971	9.960729e-01	0.002
Amyloid fiber formation	R-HSA-977225	9.960932e-01	0.002
Cellular response to starvation	R-HSA-9711097	9.962248e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.963573e-01	0.002
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.964667e-01	0.002
Maturation of spike protein	R-HSA-9694548	9.964667e-01	0.002
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.964667e-01	0.002
Glucagon-type ligand receptors	R-HSA-420092	9.966639e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.967788e-01	0.001
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.969898e-01	0.001
Nucleotide biosynthesis	R-HSA-8956320	9.970999e-01	0.001
Neurotransmitter clearance	R-HSA-112311	9.971661e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.971973e-01	0.001
Cleavage of the damaged pyrimidine	R-HSA-110329	9.973565e-01	0.001
Depyrimidination	R-HSA-73928	9.973565e-01	0.001
Mitochondrial protein degradation	R-HSA-9837999	9.978856e-01	0.001
DAG1 glycosylations	R-HSA-8931838	9.979550e-01	0.001
HS-GAG degradation	R-HSA-2024096	9.979550e-01	0.001
HCMV Late Events	R-HSA-9610379	9.979777e-01	0.001
Neddylation	R-HSA-8951664	9.981054e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.982272e-01	0.001
Defective B3GALTL causes PpS	R-HSA-5083635	9.982629e-01	0.001
Keratan sulfate biosynthesis	R-HSA-2022854	9.982629e-01	0.001
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.982629e-01	0.001
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.982934e-01	0.001
Eukaryotic Translation Termination	R-HSA-72764	9.983048e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.984831e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.985189e-01	0.001
Heme degradation	R-HSA-189483	9.985244e-01	0.001
Hyaluronan metabolism	R-HSA-2142845	9.987466e-01	0.001
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.987466e-01	0.001
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.987466e-01	0.001
GABA receptor activation	R-HSA-977443	9.988742e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.988742e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.988742e-01	0.000
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.988920e-01	0.000
Metal ion SLC transporters	R-HSA-425410	9.989012e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.989284e-01	0.000
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.989353e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.990180e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.990517e-01	0.000
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.990956e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.991283e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.991357e-01	0.000
Mitochondrial protein import	R-HSA-1268020	9.991438e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.991789e-01	0.000
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.992318e-01	0.000
Complex IV assembly	R-HSA-9864848	9.992943e-01	0.000
Collagen formation	R-HSA-1474290	9.993087e-01	0.000
tRNA processing in the mitochondrion	R-HSA-6785470	9.993475e-01	0.000
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.993475e-01	0.000
Xenobiotics	R-HSA-211981	9.993498e-01	0.000
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.994457e-01	0.000
Post-translational protein modification	R-HSA-597592	9.994736e-01	0.000
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.995292e-01	0.000
rRNA processing in the mitochondrion	R-HSA-8868766	9.995292e-01	0.000
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.995477e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.995921e-01	0.000
Aflatoxin activation and detoxification	R-HSA-5423646	9.996001e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.996265e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.996265e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.996427e-01	0.000
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.996604e-01	0.000
Heme biosynthesis	R-HSA-189451	9.996604e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.996965e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.997115e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.997476e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.997543e-01	0.000
Defective pyroptosis	R-HSA-9710421	9.997550e-01	0.000
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.997550e-01	0.000
Pyrimidine catabolism	R-HSA-73621	9.997550e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.997855e-01	0.000
Surfactant metabolism	R-HSA-5683826	9.997919e-01	0.000
Infectious disease	R-HSA-5663205	9.997923e-01	0.000
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.998232e-01	0.000
Collagen degradation	R-HSA-1442490	9.998411e-01	0.000
Endogenous sterols	R-HSA-211976	9.998411e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998654e-01	0.000
Translation	R-HSA-72766	9.998682e-01	0.000
Potassium Channels	R-HSA-1296071	9.998712e-01	0.000
Synthesis of PC	R-HSA-1483191	9.998725e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.998725e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.998917e-01	0.000
Keratan sulfate/keratin metabolism	R-HSA-1638074	9.999080e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.999080e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.999219e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.999337e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.999356e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.999480e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.999591e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999649e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999649e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.999707e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999739e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999741e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999747e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999777e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999848e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999867e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.999879e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999896e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.999907e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999924e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999924e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999957e-01	0.000
Disease	R-HSA-1643685	9.999959e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999967e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999970e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999970e-01	0.000
Classical antibody-mediated complement activation	R-HSA-173623	9.999978e-01	0.000
Purine catabolism	R-HSA-74259	9.999979e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.999979e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999984e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999987e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999988e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999992e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999994e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999994e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999995e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999996e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999997e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999997e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999997e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999997e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999997e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999998e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999998e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999999e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999999e-01	0.000
Creation of C4 and C2 activators	R-HSA-166786	9.999999e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999999e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	3.330669e-16	15.477
Cellular responses to stress	R-HSA-2262752	3.330669e-15	14.477
Cellular responses to stimuli	R-HSA-8953897	5.329071e-15	14.273
Mitotic Anaphase	R-HSA-68882	1.232348e-14	13.909
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.509903e-14	13.821
Separation of Sister Chromatids	R-HSA-2467813	8.426593e-14	13.074
M Phase	R-HSA-68886	2.102762e-13	12.677
Cell Cycle, Mitotic	R-HSA-69278	4.251044e-13	12.372
Mitotic Prometaphase	R-HSA-68877	1.665890e-12	11.778
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.951328e-12	11.710
Metabolism of RNA	R-HSA-8953854	2.107314e-12	11.676
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.356559e-12	11.628
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.733258e-12	11.563
Cellular response to heat stress	R-HSA-3371556	2.235001e-11	10.651
Aggrephagy	R-HSA-9646399	1.569543e-10	9.804
Cell-Cell communication	R-HSA-1500931	2.139049e-10	9.670
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.307381e-10	9.637
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.553603e-10	9.449
Apoptotic execution phase	R-HSA-75153	5.422436e-10	9.266
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.950497e-10	9.225
Recycling pathway of L1	R-HSA-437239	7.900113e-10	9.102
mRNA Splicing - Major Pathway	R-HSA-72163	8.585316e-10	9.066
Axon guidance	R-HSA-422475	9.122889e-10	9.040
Transport of connexons to the plasma membrane	R-HSA-190872	1.147146e-09	8.940
mRNA Splicing	R-HSA-72172	1.976955e-09	8.704
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.305141e-09	8.637
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.245387e-09	8.489
Nervous system development	R-HSA-9675108	4.073913e-09	8.390
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.287668e-09	8.277
L1CAM interactions	R-HSA-373760	7.225777e-09	8.141
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.298722e-09	8.081
G2/M Transition	R-HSA-69275	2.534037e-08	7.596
Cell junction organization	R-HSA-446728	2.655863e-08	7.576
Mitotic G2-G2/M phases	R-HSA-453274	3.425353e-08	7.465
Post NMDA receptor activation events	R-HSA-438064	3.813302e-08	7.419
Cell Cycle Checkpoints	R-HSA-69620	5.216004e-08	7.283
HSF1-dependent transactivation	R-HSA-3371571	5.603301e-08	7.252
PKR-mediated signaling	R-HSA-9833482	6.232591e-08	7.205
Regulation of CDH1 Function	R-HSA-9764561	8.514535e-08	7.070
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.231977e-08	7.035
Gap junction trafficking and regulation	R-HSA-157858	1.206458e-07	6.918
Apoptosis	R-HSA-109581	1.286691e-07	6.891
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.521169e-07	6.818
Selective autophagy	R-HSA-9663891	1.521169e-07	6.818
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.533698e-07	6.814
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.965047e-07	6.528
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.137940e-07	6.503
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.137940e-07	6.503
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.220482e-07	6.375
Gap junction trafficking	R-HSA-190828	4.130684e-07	6.384
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.502191e-07	6.347
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.280192e-07	6.032
Adherens junctions interactions	R-HSA-418990	9.659000e-07	6.015
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	9.902883e-07	6.004
Macroautophagy	R-HSA-1632852	1.034189e-06	5.985
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.264651e-06	5.898
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.307253e-06	5.884
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.445884e-06	5.840
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.408124e-06	5.851
Cohesin Loading onto Chromatin	R-HSA-2470946	1.894286e-06	5.723
Programmed Cell Death	R-HSA-5357801	2.047965e-06	5.689
Cell-cell junction organization	R-HSA-421270	2.146020e-06	5.668
Kinesins	R-HSA-983189	2.325312e-06	5.634
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.597400e-06	5.585
Downregulation of ERBB2 signaling	R-HSA-8863795	2.905367e-06	5.537
SARS-CoV-1-host interactions	R-HSA-9692914	3.053844e-06	5.515
Gap junction assembly	R-HSA-190861	3.581049e-06	5.446
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.617240e-06	5.442
Signaling by ALK in cancer	R-HSA-9700206	3.617240e-06	5.442
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.198165e-06	5.377
Autophagy	R-HSA-9612973	4.269939e-06	5.370
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.744388e-06	5.324
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.129618e-06	5.147
Cap-dependent Translation Initiation	R-HSA-72737	8.268973e-06	5.083
Eukaryotic Translation Initiation	R-HSA-72613	8.268973e-06	5.083
Membrane Trafficking	R-HSA-199991	9.082907e-06	5.042
Ribosomal scanning and start codon recognition	R-HSA-72702	9.795975e-06	5.009
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.022338e-05	4.990
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.098458e-05	4.959
Transcriptional Regulation by TP53	R-HSA-3700989	1.143439e-05	4.942
Nuclear Envelope Breakdown	R-HSA-2980766	1.228318e-05	4.911
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.512513e-05	4.820
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.532599e-05	4.815
Translation initiation complex formation	R-HSA-72649	1.997969e-05	4.699
G2/M Checkpoints	R-HSA-69481	1.970036e-05	4.706
MITF-M-regulated melanocyte development	R-HSA-9730414	2.198070e-05	4.658
MITF-M-dependent gene expression	R-HSA-9856651	2.253108e-05	4.647
COPI-mediated anterograde transport	R-HSA-6807878	2.284829e-05	4.641
Signal Transduction	R-HSA-162582	2.380318e-05	4.623
SARS-CoV-2-host interactions	R-HSA-9705683	2.577397e-05	4.589
Regulation of MECP2 expression and activity	R-HSA-9022692	3.066482e-05	4.513
Downregulation of ERBB4 signaling	R-HSA-1253288	3.167981e-05	4.499
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.167981e-05	4.499
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.284983e-05	4.483
Influenza Infection	R-HSA-168255	3.677260e-05	4.434
Nucleotide Excision Repair	R-HSA-5696398	4.280975e-05	4.368
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.769349e-05	4.239
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.829048e-05	4.234
Degradation of CDH1	R-HSA-9766229	6.605651e-05	4.180
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.357995e-05	4.197
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.605677e-05	4.180
Signaling by ERBB2	R-HSA-1227986	7.000205e-05	4.155
Attenuation phase	R-HSA-3371568	7.035629e-05	4.153
Regulation of TP53 Activity	R-HSA-5633007	7.395575e-05	4.131
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.622335e-05	4.118
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.851971e-05	4.053
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	8.851971e-05	4.053
Cellular Senescence	R-HSA-2559583	8.383598e-05	4.077
MAPK family signaling cascades	R-HSA-5683057	8.356556e-05	4.078
Regulation of TP53 Degradation	R-HSA-6804757	8.979105e-05	4.047
SARS-CoV-1 Infection	R-HSA-9678108	1.000257e-04	4.000
MAPK6/MAPK4 signaling	R-HSA-5687128	1.038791e-04	3.983
Mitotic Spindle Checkpoint	R-HSA-69618	1.042246e-04	3.982
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.077086e-04	3.968
PTEN Regulation	R-HSA-6807070	1.178580e-04	3.929
Gene expression (Transcription)	R-HSA-74160	1.498445e-04	3.824
Smooth Muscle Contraction	R-HSA-445355	1.511239e-04	3.821
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.649643e-04	3.783
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.766862e-04	3.753
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.818665e-04	3.740
Intracellular signaling by second messengers	R-HSA-9006925	1.698402e-04	3.770
S Phase	R-HSA-69242	1.748672e-04	3.757
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.765992e-04	3.753
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.822848e-04	3.739
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.843885e-04	3.734
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.844604e-04	3.734
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.882580e-04	3.725
Clathrin-mediated endocytosis	R-HSA-8856828	2.085234e-04	3.681
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.202481e-04	3.657
HIV Life Cycle	R-HSA-162587	2.255037e-04	3.647
Cilium Assembly	R-HSA-5617833	2.282472e-04	3.642
Hedgehog 'off' state	R-HSA-5610787	2.452452e-04	3.610
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.610872e-04	3.583
NF-kB is activated and signals survival	R-HSA-209560	2.610872e-04	3.583
p75NTR signals via NF-kB	R-HSA-193639	2.616902e-04	3.582
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.616902e-04	3.582
Cell-extracellular matrix interactions	R-HSA-446353	2.616902e-04	3.582
mTORC1-mediated signalling	R-HSA-166208	2.814786e-04	3.551
HSF1 activation	R-HSA-3371511	3.021672e-04	3.520
Amplification of signal from the kinetochores	R-HSA-141424	3.002636e-04	3.522
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.002636e-04	3.522
Host Interactions of HIV factors	R-HSA-162909	2.986955e-04	3.525
Signaling downstream of RAS mutants	R-HSA-9649948	3.275004e-04	3.485
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.275004e-04	3.485
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.275004e-04	3.485
Signaling by RAS mutants	R-HSA-6802949	3.275004e-04	3.485
ISG15 antiviral mechanism	R-HSA-1169408	3.506139e-04	3.455
Signaling by RAF1 mutants	R-HSA-9656223	3.553857e-04	3.449
mRNA 3'-end processing	R-HSA-72187	3.589927e-04	3.445
Estrogen-dependent gene expression	R-HSA-9018519	3.698587e-04	3.432
Late Phase of HIV Life Cycle	R-HSA-162599	3.840455e-04	3.416
PIP3 activates AKT signaling	R-HSA-1257604	3.941877e-04	3.404
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.984801e-04	3.400
Interleukin-12 signaling	R-HSA-9020591	4.085173e-04	3.389
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.706390e-04	3.327
Cellular response to starvation	R-HSA-9711097	4.965173e-04	3.304
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.074199e-04	3.295
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.074199e-04	3.295
Regulation of PTEN gene transcription	R-HSA-8943724	5.376305e-04	3.270
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.812712e-04	3.236
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.904784e-04	3.229
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.148128e-04	3.211
Oncogenic MAPK signaling	R-HSA-6802957	6.213010e-04	3.207
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.428509e-04	3.192
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	6.428509e-04	3.192
ATP-dependent chromatin remodelers	R-HSA-9932444	6.482834e-04	3.188
SWI/SNF chromatin remodelers	R-HSA-9932451	6.482834e-04	3.188
Long-term potentiation	R-HSA-9620244	6.482834e-04	3.188
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	7.132238e-04	3.147
Signaling by Hippo	R-HSA-2028269	7.394056e-04	3.131
Interactions of Rev with host cellular proteins	R-HSA-177243	7.132238e-04	3.147
Signaling by ROBO receptors	R-HSA-376176	7.317514e-04	3.136
Listeria monocytogenes entry into host cells	R-HSA-8876384	8.160496e-04	3.088
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.602590e-04	3.065
Centrosome maturation	R-HSA-380287	8.602590e-04	3.065
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.720665e-04	3.059
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.720665e-04	3.059
Semaphorin interactions	R-HSA-373755	8.720665e-04	3.059
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.883061e-04	3.005
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.883061e-04	3.005
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.883061e-04	3.005
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.883061e-04	3.005
Ribosome-associated quality control	R-HSA-9948299	9.194126e-04	3.036
Transcriptional regulation by RUNX1	R-HSA-8878171	8.991036e-04	3.046
Eukaryotic Translation Elongation	R-HSA-156842	8.905812e-04	3.050
Golgi-to-ER retrograde transport	R-HSA-8856688	8.977344e-04	3.047
HIV Infection	R-HSA-162906	9.718408e-04	3.012
Chromatin organization	R-HSA-4839726	9.863673e-04	3.006
Chaperonin-mediated protein folding	R-HSA-390466	9.292241e-04	3.032
Interleukin-12 family signaling	R-HSA-447115	9.292241e-04	3.032
Chaperone Mediated Autophagy	R-HSA-9613829	1.004829e-03	2.998
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.004829e-03	2.998
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.009751e-03	2.996
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.048665e-03	2.979
FLT3 signaling by CBL mutants	R-HSA-9706377	1.048665e-03	2.979
p75 NTR receptor-mediated signalling	R-HSA-193704	1.081876e-03	2.966
DNA Double-Strand Break Repair	R-HSA-5693532	1.146346e-03	2.941
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.166649e-03	2.933
Metabolism of non-coding RNA	R-HSA-194441	1.183802e-03	2.927
snRNP Assembly	R-HSA-191859	1.183802e-03	2.927
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.195204e-03	2.923
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.195204e-03	2.923
ESR-mediated signaling	R-HSA-8939211	1.196216e-03	2.922
SARS-CoV-2 Infection	R-HSA-9694516	1.210280e-03	2.917
Death Receptor Signaling	R-HSA-73887	1.257448e-03	2.901
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.269024e-03	2.897
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.269024e-03	2.897
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.340790e-03	2.873
AURKA Activation by TPX2	R-HSA-8854518	1.370407e-03	2.863
Formation of a pool of free 40S subunits	R-HSA-72689	1.453609e-03	2.838
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.360697e-03	2.866
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.346200e-03	2.871
Intraflagellar transport	R-HSA-5620924	1.336955e-03	2.874
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.303681e-03	2.885
DNA Repair	R-HSA-73894	1.484010e-03	2.829
Transcriptional Regulation by MECP2	R-HSA-8986944	1.538277e-03	2.813
Switching of origins to a post-replicative state	R-HSA-69052	1.542202e-03	2.812
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.563311e-03	2.806
RNA Polymerase II Transcription Termination	R-HSA-73856	1.606739e-03	2.794
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.765163e-03	2.753
G2/M DNA damage checkpoint	R-HSA-69473	1.765778e-03	2.753
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.766410e-03	2.753
Nephrin family interactions	R-HSA-373753	1.766410e-03	2.753
Cytokine Signaling in Immune system	R-HSA-1280215	1.784218e-03	2.749
Signaling by Hedgehog	R-HSA-5358351	1.788276e-03	2.748
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.814697e-03	2.741
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.834235e-03	2.737
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.874131e-03	2.727
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.878749e-03	2.726
Nuclear import of Rev protein	R-HSA-180746	1.911621e-03	2.719
p75NTR recruits signalling complexes	R-HSA-209543	1.923685e-03	2.716
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.947779e-03	2.710
Protein folding	R-HSA-391251	1.953388e-03	2.709
TCR signaling	R-HSA-202403	1.988183e-03	2.702
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.063527e-03	2.685
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.075530e-03	2.683
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.091280e-03	2.680
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.214216e-03	2.655
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.214216e-03	2.655
TGFBR3 expression	R-HSA-9839394	2.230751e-03	2.652
Oncogene Induced Senescence	R-HSA-2559585	2.321117e-03	2.634
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.572136e-03	2.590
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.572136e-03	2.590
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.540137e-03	2.595
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.731526e-03	2.564
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.540137e-03	2.595
Interferon Signaling	R-HSA-913531	2.420996e-03	2.616
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.685863e-03	2.571
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.475284e-03	2.606
Chromatin modifying enzymes	R-HSA-3247509	2.770379e-03	2.557
Myogenesis	R-HSA-525793	2.790267e-03	2.554
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.799478e-03	2.553
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.925081e-03	2.534
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.932364e-03	2.533
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.069589e-03	2.513
Josephin domain DUBs	R-HSA-5689877	3.069589e-03	2.513
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.108128e-03	2.508
Transcriptional regulation by small RNAs	R-HSA-5578749	3.108128e-03	2.508
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.254585e-03	2.488
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.298824e-03	2.482
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.354894e-03	2.474
Interaction between L1 and Ankyrins	R-HSA-445095	3.456589e-03	2.461
NRIF signals cell death from the nucleus	R-HSA-205043	3.660773e-03	2.436
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.660773e-03	2.436
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.660773e-03	2.436
Platelet degranulation	R-HSA-114608	3.697647e-03	2.432
IPs transport between nucleus and cytosol	R-HSA-1855170	3.801035e-03	2.420
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.801035e-03	2.420
Ephrin signaling	R-HSA-3928664	3.815931e-03	2.418
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.905850e-03	2.408
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.991423e-03	2.399
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.019177e-03	2.396
Regulation of PTEN localization	R-HSA-8948747	4.809399e-03	2.318
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.883626e-03	2.311
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.883626e-03	2.311
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.894675e-03	2.310
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	4.635205e-03	2.334
Striated Muscle Contraction	R-HSA-390522	4.570655e-03	2.340
Peptide chain elongation	R-HSA-156902	4.936562e-03	2.307
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.822926e-03	2.317
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.822926e-03	2.317
Processing of DNA double-strand break ends	R-HSA-5693607	4.230153e-03	2.374
Regulation of T cell activation by CD28 family	R-HSA-388841	4.385542e-03	2.358
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.381863e-03	2.358
Translesion Synthesis by POLH	R-HSA-110320	4.894675e-03	2.310
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.381863e-03	2.358
tRNA processing in the nucleus	R-HSA-6784531	4.412887e-03	2.355
Vesicle-mediated transport	R-HSA-5653656	4.345843e-03	2.362
ER to Golgi Anterograde Transport	R-HSA-199977	4.319980e-03	2.365
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.570655e-03	2.340
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.732032e-03	2.325
RAF/MAP kinase cascade	R-HSA-5673001	5.085890e-03	2.294
Organelle biogenesis and maintenance	R-HSA-1852241	5.113428e-03	2.291
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.160884e-03	2.287
Glycolysis	R-HSA-70171	5.189476e-03	2.285
Homology Directed Repair	R-HSA-5693538	5.313724e-03	2.275
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.459028e-03	2.263
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.552420e-03	2.256
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.635869e-03	2.249
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.790759e-03	2.237
Dual incision in TC-NER	R-HSA-6782135	6.002494e-03	2.222
Interleukin-37 signaling	R-HSA-9008059	6.236383e-03	2.205
Formation of RNA Pol II elongation complex	R-HSA-112382	6.252408e-03	2.204
Orc1 removal from chromatin	R-HSA-68949	6.252408e-03	2.204
Mitotic Prophase	R-HSA-68875	6.356200e-03	2.197
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.437877e-03	2.191
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.478243e-03	2.189
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.478243e-03	2.189
rRNA processing	R-HSA-72312	6.520369e-03	2.186
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.527188e-03	2.185
Transcriptional Regulation by VENTX	R-HSA-8853884	6.527188e-03	2.185
Deubiquitination	R-HSA-5688426	6.575644e-03	2.182
Sema4D in semaphorin signaling	R-HSA-400685	7.022999e-03	2.153
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.105520e-03	2.148
Formation of annular gap junctions	R-HSA-196025	7.105520e-03	2.148
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.163142e-03	2.145
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.163142e-03	2.145
Meiotic synapsis	R-HSA-1221632	7.163142e-03	2.145
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	7.213788e-03	2.142
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	7.213788e-03	2.142
NrCAM interactions	R-HSA-447038	7.213788e-03	2.142
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	7.502464e-03	2.125
MAPK1/MAPK3 signaling	R-HSA-5684996	7.543763e-03	2.122
MAP2K and MAPK activation	R-HSA-5674135	7.606564e-03	2.119
FLT3 signaling in disease	R-HSA-9682385	7.640797e-03	2.117
Muscle contraction	R-HSA-397014	7.746766e-03	2.111
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.746766e-03	2.111
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.754807e-03	2.110
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.176409e-03	2.087
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.181514e-03	2.087
DNA Double Strand Break Response	R-HSA-5693606	8.224299e-03	2.085
MHC class II antigen presentation	R-HSA-2132295	8.232282e-03	2.084
Gap junction degradation	R-HSA-190873	1.007389e-02	1.997
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.050601e-02	1.979
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.299880e-03	2.032
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.054139e-02	1.977
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.016350e-02	1.993
Co-inhibition by PD-1	R-HSA-389948	8.873055e-03	2.052
Signaling by EGFR	R-HSA-177929	1.054139e-02	1.977
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.892603e-03	2.005
Epigenetic regulation of gene expression	R-HSA-212165	9.083542e-03	2.042
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.007389e-02	1.997
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.190244e-03	2.037
MTOR signalling	R-HSA-165159	8.821135e-03	2.054
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.552693e-03	2.020
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.036465e-02	1.984
Signaling by VEGF	R-HSA-194138	1.053917e-02	1.977
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.018170e-02	1.992
RNA Polymerase II Transcription	R-HSA-73857	1.024541e-02	1.989
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.552693e-03	2.020
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.552693e-03	2.020
SARS-CoV Infections	R-HSA-9679506	8.904225e-03	2.050
UCH proteinases	R-HSA-5689603	1.066551e-02	1.972
Synthesis of DNA	R-HSA-69239	1.097796e-02	1.959
Gene Silencing by RNA	R-HSA-211000	1.097796e-02	1.959
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.114307e-02	1.953
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.132737e-02	1.946
Maturation of protein E	R-HSA-9694493	1.132737e-02	1.946
Maturation of protein E	R-HSA-9683683	1.132737e-02	1.946
Viral Infection Pathways	R-HSA-9824446	1.159577e-02	1.936
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.166851e-02	1.933
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.166851e-02	1.933
Unfolded Protein Response (UPR)	R-HSA-381119	1.177130e-02	1.929
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.213197e-02	1.916
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.260822e-02	1.899
Regulation of mitotic cell cycle	R-HSA-453276	1.286771e-02	1.890
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.286771e-02	1.890
Meiosis	R-HSA-1500620	1.327073e-02	1.877
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.338489e-02	1.873
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.379701e-02	1.860
Pexophagy	R-HSA-9664873	1.379701e-02	1.860
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.391103e-02	1.857
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.398439e-02	1.854
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.411053e-02	1.850
MyD88-independent TLR4 cascade	R-HSA-166166	1.417273e-02	1.849
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.417273e-02	1.849
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.429611e-02	1.845
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.434881e-02	1.843
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.434881e-02	1.843
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.434881e-02	1.843
Developmental Biology	R-HSA-1266738	1.439171e-02	1.842
Dual Incision in GG-NER	R-HSA-5696400	1.439351e-02	1.842
Transcriptional regulation by RUNX3	R-HSA-8878159	1.452394e-02	1.838
Signaling by TGFBR3	R-HSA-9839373	1.524975e-02	1.817
EPH-Ephrin signaling	R-HSA-2682334	1.599257e-02	1.796
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.605996e-02	1.794
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.618665e-02	1.791
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	1.670658e-02	1.777
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.670658e-02	1.777
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.690485e-02	1.772
Neurodegenerative Diseases	R-HSA-8863678	1.690485e-02	1.772
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.690485e-02	1.772
Diseases of Telomere Maintenance	R-HSA-9673013	1.982728e-02	1.703
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.982728e-02	1.703
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.982728e-02	1.703
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.982728e-02	1.703
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.982728e-02	1.703
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.982728e-02	1.703
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.710945e-02	1.767
PECAM1 interactions	R-HSA-210990	1.834875e-02	1.736
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	1.834875e-02	1.736
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.762789e-02	1.754
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.762789e-02	1.754
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.762789e-02	1.754
Negative regulation of FLT3	R-HSA-9706369	2.197431e-02	1.658
Translesion synthesis by POLI	R-HSA-5656121	2.197431e-02	1.658
Regulation of PD-L1(CD274) translation	R-HSA-9909620	1.947912e-02	1.710
Negative regulation of MET activity	R-HSA-6807004	1.947912e-02	1.710
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.704236e-02	1.768
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.990330e-02	1.701
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.730498e-02	1.762
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.956162e-02	1.709
Protein ubiquitination	R-HSA-8852135	1.934683e-02	1.713
Regulation of endogenous retroelements	R-HSA-9842860	2.213806e-02	1.655
DNA Damage Bypass	R-HSA-73893	2.203056e-02	1.657
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.990330e-02	1.701
MicroRNA (miRNA) biogenesis	R-HSA-203927	2.007667e-02	1.697
EGFR downregulation	R-HSA-182971	1.990330e-02	1.701
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.762789e-02	1.754
HCMV Early Events	R-HSA-9609690	1.782237e-02	1.749
Translesion synthesis by REV1	R-HSA-110312	1.762789e-02	1.754
Evasion by RSV of host interferon responses	R-HSA-9833109	1.990330e-02	1.701
Trafficking of AMPA receptors	R-HSA-399719	1.990330e-02	1.701
Assembly of the pre-replicative complex	R-HSA-68867	1.747848e-02	1.757
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.990330e-02	1.701
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.953242e-02	1.709
Ovarian tumor domain proteases	R-HSA-5689896	2.211042e-02	1.655
Formation of definitive endoderm	R-HSA-9823730	1.947912e-02	1.710
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.089142e-02	1.680
Eukaryotic Translation Termination	R-HSA-72764	2.258539e-02	1.646
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.174678e-02	1.663
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.947912e-02	1.710
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.934683e-02	1.713
Viral Messenger RNA Synthesis	R-HSA-168325	1.880179e-02	1.726
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.730498e-02	1.762
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.764003e-02	1.754
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.956162e-02	1.709
Activation of BH3-only proteins	R-HSA-114452	1.704236e-02	1.768
NRAGE signals death through JNK	R-HSA-193648	2.277898e-02	1.642
TNF signaling	R-HSA-75893	2.277898e-02	1.642
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.340593e-02	1.631
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.345241e-02	1.630
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.345241e-02	1.630
Recycling of eIF2:GDP	R-HSA-72731	2.345408e-02	1.630
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.364999e-02	1.626
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.379271e-02	1.624
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.379271e-02	1.624
Activation of ATR in response to replication stress	R-HSA-176187	2.663781e-02	1.575
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.663781e-02	1.575
Translesion synthesis by POLK	R-HSA-5655862	2.699050e-02	1.569
Regulation of gap junction activity	R-HSA-191650	2.735836e-02	1.563
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.735836e-02	1.563
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	2.764733e-02	1.558
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.764733e-02	1.558
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.764733e-02	1.558
Activation of NF-kappaB in B cells	R-HSA-1169091	2.764772e-02	1.558
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.795079e-02	1.554
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.795079e-02	1.554
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.795079e-02	1.554
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.816509e-02	1.550
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.830788e-02	1.548
Glucose metabolism	R-HSA-70326	2.831201e-02	1.548
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.869317e-02	1.542
Stabilization of p53	R-HSA-69541	2.869317e-02	1.542
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.018101e-02	1.520
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.018101e-02	1.520
Interleukin-1 family signaling	R-HSA-446652	3.037221e-02	1.518
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.081631e-02	1.511
Signaling by TGFB family members	R-HSA-9006936	3.090956e-02	1.510
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.122648e-02	1.505
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.164064e-02	1.500
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.164064e-02	1.500
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.164064e-02	1.500
Modulation by Mtb of host immune system	R-HSA-9637628	3.164064e-02	1.500
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.164064e-02	1.500
Signaling by Interleukins	R-HSA-449147	3.180240e-02	1.498
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.245916e-02	1.489
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.245916e-02	1.489
Regulation of TNFR1 signaling	R-HSA-5357905	3.362816e-02	1.473
Cellular responses to mechanical stimuli	R-HSA-9855142	3.375373e-02	1.472
Signaling by NOTCH4	R-HSA-9013694	3.392952e-02	1.469
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.423783e-02	1.465
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.423783e-02	1.465
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.429733e-02	1.465
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.442628e-02	1.463
RAF activation	R-HSA-5673000	3.483824e-02	1.458
Selenocysteine synthesis	R-HSA-2408557	3.612628e-02	1.442
FLT3 Signaling	R-HSA-9607240	3.655888e-02	1.437
Hh mutants are degraded by ERAD	R-HSA-5362768	3.655888e-02	1.437
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.655888e-02	1.437
PKMTs methylate histone lysines	R-HSA-3214841	3.655888e-02	1.437
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.699510e-02	1.432
Late endosomal microautophagy	R-HSA-9615710	3.699510e-02	1.432
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.727719e-02	1.429
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.755365e-02	1.425
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.755365e-02	1.425
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.755365e-02	1.425
MAP kinase activation	R-HSA-450294	3.790548e-02	1.421
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.792135e-02	1.421
Regulation of PTEN mRNA translation	R-HSA-8943723	3.862368e-02	1.413
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.874682e-02	1.412
Oxidative Stress Induced Senescence	R-HSA-2559580	3.886513e-02	1.410
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.916515e-02	1.407
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.916515e-02	1.407
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.916515e-02	1.407
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.916515e-02	1.407
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.952701e-02	1.403
Regulation of Apoptosis	R-HSA-169911	3.952701e-02	1.403
IRS activation	R-HSA-74713	4.022021e-02	1.396
DNA Replication Pre-Initiation	R-HSA-69002	4.024497e-02	1.395
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.100412e-02	1.387
Manipulation of host energy metabolism	R-HSA-9636667	4.161352e-02	1.381
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.560850e-02	1.255
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.560850e-02	1.255
IkBA variant leads to EDA-ID	R-HSA-5603029	5.560850e-02	1.255
Regulation of KIT signaling	R-HSA-1433559	4.593810e-02	1.338
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.593810e-02	1.338
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.534943e-02	1.257
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.534943e-02	1.257
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.534943e-02	1.257
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	5.435575e-02	1.265
Signaling by EGFR in Cancer	R-HSA-1643713	5.910856e-02	1.228
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.910856e-02	1.228
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.580558e-02	1.339
Viral mRNA Translation	R-HSA-192823	4.175260e-02	1.379
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.269362e-02	1.370
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.910856e-02	1.228
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.593810e-02	1.338
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.480942e-02	1.349
NoRC negatively regulates rRNA expression	R-HSA-427413	4.876753e-02	1.312
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.296210e-02	1.276
Apoptosis induced DNA fragmentation	R-HSA-140342	5.246108e-02	1.280
DCC mediated attractive signaling	R-HSA-418885	5.534943e-02	1.257
Metalloprotease DUBs	R-HSA-5689901	5.910856e-02	1.228
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.162719e-02	1.381
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.560850e-02	1.255
Regulation of CDH11 function	R-HSA-9762292	5.246108e-02	1.280
Diseases of mitotic cell cycle	R-HSA-9675126	5.464713e-02	1.262
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.534943e-02	1.257
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.914833e-02	1.228
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.480942e-02	1.349
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.097275e-02	1.293
Breakdown of the nuclear lamina	R-HSA-352238	4.161352e-02	1.381
G alpha (12/13) signalling events	R-HSA-416482	4.753076e-02	1.323
Response of endothelial cells to shear stress	R-HSA-9860931	4.479250e-02	1.349
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.876753e-02	1.312
Regulation of signaling by CBL	R-HSA-912631	4.637471e-02	1.334
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.622783e-02	1.335
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.622783e-02	1.335
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.989573e-02	1.302
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.649143e-02	1.333
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.989573e-02	1.302
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.989573e-02	1.302
Beta-catenin independent WNT signaling	R-HSA-3858494	4.407708e-02	1.356
Unwinding of DNA	R-HSA-176974	4.130607e-02	1.384
Hedgehog ligand biogenesis	R-HSA-5358346	5.622000e-02	1.250
Downstream TCR signaling	R-HSA-202424	4.147072e-02	1.382
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.483999e-02	1.348
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.130607e-02	1.384
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.559841e-02	1.341
Cellular response to mitochondrial stress	R-HSA-9840373	4.130607e-02	1.384
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.610788e-02	1.336
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.246108e-02	1.280
Spry regulation of FGF signaling	R-HSA-1295596	5.534943e-02	1.257
ABC-family proteins mediated transport	R-HSA-382556	5.722582e-02	1.242
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.154837e-02	1.211
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.560850e-02	1.255
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.171551e-02	1.210
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.239919e-02	1.205
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.243582e-02	1.205
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.243582e-02	1.205
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.243582e-02	1.205
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.311747e-02	1.200
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.311747e-02	1.200
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.311747e-02	1.200
Ub-specific processing proteases	R-HSA-5689880	6.575116e-02	1.182
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.579054e-02	1.182
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.579054e-02	1.182
Regulation of NF-kappa B signaling	R-HSA-9758274	6.579054e-02	1.182
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.642337e-02	1.178
EPHA-mediated growth cone collapse	R-HSA-3928663	6.717937e-02	1.173
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.717937e-02	1.173
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.717937e-02	1.173
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.717937e-02	1.173
Regulation of PTEN stability and activity	R-HSA-8948751	6.755126e-02	1.170
mRNA Splicing - Minor Pathway	R-HSA-72165	6.874413e-02	1.163
Vpu mediated degradation of CD4	R-HSA-180534	6.897108e-02	1.161
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	6.905347e-02	1.161
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.905347e-02	1.161
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.905347e-02	1.161
Generation of second messenger molecules	R-HSA-202433	6.932420e-02	1.159
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.266249e-02	1.139
Nef and signal transduction	R-HSA-164944	7.337194e-02	1.134
Signaling by NOTCH	R-HSA-157118	7.432030e-02	1.129
HIV elongation arrest and recovery	R-HSA-167287	7.588010e-02	1.120
Pausing and recovery of HIV elongation	R-HSA-167290	7.588010e-02	1.120
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.588010e-02	1.120
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.660830e-02	1.116
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.660830e-02	1.116
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.691888e-02	1.114
Mitophagy	R-HSA-5205647	7.691888e-02	1.114
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.691888e-02	1.114
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.691888e-02	1.114
Calnexin/calreticulin cycle	R-HSA-901042	7.691888e-02	1.114
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.725281e-02	1.112
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.725281e-02	1.112
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.725281e-02	1.112
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.725281e-02	1.112
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.915376e-02	1.102
Signaling by NOTCH3	R-HSA-9012852	8.025886e-02	1.096
G1/S Transition	R-HSA-69206	8.050264e-02	1.094
Mitotic G1 phase and G1/S transition	R-HSA-453279	8.069618e-02	1.093
Cyclin E associated events during G1/S transition	R-HSA-69202	8.085304e-02	1.092
Interleukin-17 signaling	R-HSA-448424	8.085304e-02	1.092
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.298701e-02	1.081
G1/S DNA Damage Checkpoints	R-HSA-69615	8.404317e-02	1.075
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.404317e-02	1.075
Signaling by PTK6	R-HSA-8848021	8.404317e-02	1.075
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.427728e-02	1.074
Degradation of CRY and PER proteins	R-HSA-9932298	8.434304e-02	1.074
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.434304e-02	1.074
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.434304e-02	1.074
Negative regulation of MAPK pathway	R-HSA-5675221	8.434304e-02	1.074
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.472411e-02	1.072
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.472411e-02	1.072
Termination of translesion DNA synthesis	R-HSA-5656169	8.520985e-02	1.070
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.520985e-02	1.070
PERK regulates gene expression	R-HSA-381042	8.539262e-02	1.069
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.539262e-02	1.069
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.971678e-02	1.047
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.971678e-02	1.047
Regulation of NPAS4 gene expression	R-HSA-9768759	8.971678e-02	1.047
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.002045e-02	1.046
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.002045e-02	1.046
Ion transport by P-type ATPases	R-HSA-936837	9.069802e-02	1.042
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.069802e-02	1.042
XBP1(S) activates chaperone genes	R-HSA-381038	9.104587e-02	1.041
Ca-dependent events	R-HSA-111996	9.252837e-02	1.034
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.252837e-02	1.034
Generic Transcription Pathway	R-HSA-212436	9.297701e-02	1.032
RUNX3 regulates WNT signaling	R-HSA-8951430	9.331409e-02	1.030
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	9.331409e-02	1.030
Cation-coupled Chloride cotransporters	R-HSA-426117	9.331409e-02	1.030
Uptake and function of diphtheria toxin	R-HSA-5336415	9.331409e-02	1.030
Syndecan interactions	R-HSA-3000170	9.408102e-02	1.026
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.439041e-02	1.025
RNA Polymerase III Transcription	R-HSA-74158	9.439041e-02	1.025
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.439041e-02	1.025
Calmodulin induced events	R-HSA-111933	9.439041e-02	1.025
CaM pathway	R-HSA-111997	9.439041e-02	1.025
RET signaling	R-HSA-8853659	9.439041e-02	1.025
Repression of WNT target genes	R-HSA-4641265	9.459312e-02	1.024
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	9.459312e-02	1.024
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	9.459312e-02	1.024
IRAK1 recruits IKK complex	R-HSA-937039	9.459312e-02	1.024
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	9.459312e-02	1.024
VLDLR internalisation and degradation	R-HSA-8866427	9.459312e-02	1.024
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.516372e-02	1.022
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.551546e-02	1.020
Adaptive Immune System	R-HSA-1280218	9.750995e-02	1.011
Cellular response to hypoxia	R-HSA-1234174	9.766731e-02	1.010
Regulation of RAS by GAPs	R-HSA-5658442	9.790004e-02	1.009
Transmission across Chemical Synapses	R-HSA-112315	9.799834e-02	1.009
Interleukin-1 signaling	R-HSA-9020702	9.891142e-02	1.005
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.954742e-02	1.002
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.954742e-02	1.002
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.955751e-02	1.002
Ca2+ pathway	R-HSA-4086398	1.001568e-01	0.999
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.007784e-01	0.997
MET interacts with TNS proteins	R-HSA-8875513	1.007784e-01	0.997
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.007784e-01	0.997
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.007784e-01	0.997
Drug resistance of FLT3 mutants	R-HSA-9702506	1.013645e-01	0.994
Drug resistance of KIT mutants	R-HSA-9669937	1.013645e-01	0.994
KIT mutants bind TKIs	R-HSA-9669921	1.013645e-01	0.994
FLT3 mutants bind TKIs	R-HSA-9702509	1.013645e-01	0.994
quizartinib-resistant FLT3 mutants	R-HSA-9702620	1.013645e-01	0.994
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.013645e-01	0.994
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	1.013645e-01	0.994
sorafenib-resistant FLT3 mutants	R-HSA-9702624	1.013645e-01	0.994
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.013645e-01	0.994
ponatinib-resistant FLT3 mutants	R-HSA-9702614	1.013645e-01	0.994
linifanib-resistant FLT3 mutants	R-HSA-9702998	1.013645e-01	0.994
tandutinib-resistant FLT3 mutants	R-HSA-9702636	1.013645e-01	0.994
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	1.013645e-01	0.994
KW2449-resistant FLT3 mutants	R-HSA-9702569	1.013645e-01	0.994
sunitinib-resistant FLT3 mutants	R-HSA-9702632	1.013645e-01	0.994
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.013645e-01	0.994
midostaurin-resistant FLT3 mutants	R-HSA-9702600	1.013645e-01	0.994
Masitinib-resistant KIT mutants	R-HSA-9669924	1.013645e-01	0.994
semaxanib-resistant FLT3 mutants	R-HSA-9702577	1.013645e-01	0.994
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.013645e-01	0.994
crenolanib-resistant FLT3 mutants	R-HSA-9702581	1.013645e-01	0.994
Imatinib-resistant KIT mutants	R-HSA-9669917	1.013645e-01	0.994
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.013645e-01	0.994
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	1.013645e-01	0.994
tamatinib-resistant FLT3 mutants	R-HSA-9703009	1.013645e-01	0.994
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.031531e-01	0.987
Degradation of DVL	R-HSA-4641258	1.039076e-01	0.983
Degradation of AXIN	R-HSA-4641257	1.039076e-01	0.983
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.039076e-01	0.983
Platelet activation, signaling and aggregation	R-HSA-76002	1.039263e-01	0.983
Budding and maturation of HIV virion	R-HSA-162588	1.057330e-01	0.976
TRAF6 mediated NF-kB activation	R-HSA-933542	1.059286e-01	0.975
HCMV Infection	R-HSA-9609646	1.086886e-01	0.964
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.924597e-01	0.716
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.924597e-01	0.716
Defective ACTH causes obesity and POMCD	R-HSA-5579031	1.924597e-01	0.716
TICAM1 deficiency - HSE	R-HSA-5602566	1.924597e-01	0.716
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.924597e-01	0.716
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.924597e-01	0.716
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.924597e-01	0.716
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.356388e-01	0.868
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.356388e-01	0.868
NADE modulates death signalling	R-HSA-205025	1.356388e-01	0.868
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.356388e-01	0.868
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.726738e-01	0.763
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.726738e-01	0.763
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.726738e-01	0.763
Type I hemidesmosome assembly	R-HSA-446107	1.152091e-01	0.939
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.152091e-01	0.939
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.388142e-01	0.858
Regulated proteolysis of p75NTR	R-HSA-193692	1.388142e-01	0.858
Noncanonical activation of NOTCH3	R-HSA-9017802	2.110851e-01	0.676
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.110851e-01	0.676
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.113320e-01	0.953
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.483380e-01	0.829
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.175235e-01	0.930
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.175235e-01	0.930
Phosphorylation of the APC/C	R-HSA-176412	1.683963e-01	0.774
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.173996e-01	0.663
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.173996e-01	0.663
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.488753e-01	0.827
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.893418e-01	0.723
Disorders of Developmental Biology	R-HSA-9675151	1.893418e-01	0.723
G beta:gamma signalling through CDC42	R-HSA-8964616	1.893418e-01	0.723
RNA Polymerase I Transcription Termination	R-HSA-73863	1.457545e-01	0.836
PI3K events in ERBB2 signaling	R-HSA-1963642	2.110577e-01	0.676
FGFR2 alternative splicing	R-HSA-6803529	1.833287e-01	0.737
Notch-HLH transcription pathway	R-HSA-350054	1.833287e-01	0.737
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.603545e-01	0.795
Formation of the Early Elongation Complex	R-HSA-113418	1.603545e-01	0.795
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.244689e-01	0.905
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.015589e-01	0.696
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.015589e-01	0.696
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.755556e-01	0.756
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.538633e-01	0.813
HIV Transcription Elongation	R-HSA-167169	1.354909e-01	0.868
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.354909e-01	0.868
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.354909e-01	0.868
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.354909e-01	0.868
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.354909e-01	0.868
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.400747e-01	0.854
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.589450e-01	0.799
HIV Transcription Initiation	R-HSA-167161	1.589450e-01	0.799
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.589450e-01	0.799
HDACs deacetylate histones	R-HSA-3214815	1.430865e-01	0.844
Transcription of the HIV genome	R-HSA-167172	1.204527e-01	0.919
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.204527e-01	0.919
RNA Polymerase II Promoter Escape	R-HSA-73776	1.841582e-01	0.735
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.109597e-01	0.676
Post-translational protein phosphorylation	R-HSA-8957275	1.305805e-01	0.884
Signaling by ERBB4	R-HSA-1236394	1.741622e-01	0.759
G0 and Early G1	R-HSA-1538133	1.169051e-01	0.932
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.122948e-01	0.673
Signaling by SCF-KIT	R-HSA-1433557	1.841582e-01	0.735
Prolonged ERK activation events	R-HSA-169893	1.683963e-01	0.774
Co-stimulation by CD28	R-HSA-389356	1.508537e-01	0.821
Activation of the pre-replicative complex	R-HSA-68962	1.913159e-01	0.718
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.102407e-01	0.958
NPAS4 regulates expression of target genes	R-HSA-9768919	1.538633e-01	0.813
EPHB-mediated forward signaling	R-HSA-3928662	1.102407e-01	0.958
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.913159e-01	0.718
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.755556e-01	0.756
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	1.726738e-01	0.763
DNA strand elongation	R-HSA-69190	1.169051e-01	0.932
RNA Polymerase I Transcription	R-HSA-73864	1.379975e-01	0.860
GP1b-IX-V activation signalling	R-HSA-430116	1.388142e-01	0.858
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.538633e-01	0.813
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.197577e-01	0.922
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.113320e-01	0.953
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.483380e-01	0.829
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.893418e-01	0.723
Fanconi Anemia Pathway	R-HSA-6783310	2.109597e-01	0.676
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.893418e-01	0.723
Integration of provirus	R-HSA-162592	2.173996e-01	0.663
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.942988e-01	0.712
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.672560e-01	0.777
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.087385e-01	0.964
Activation and oligomerization of BAK protein	R-HSA-111452	1.924597e-01	0.716
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.356388e-01	0.868
TNFR1-mediated ceramide production	R-HSA-5626978	1.356388e-01	0.868
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.726738e-01	0.763
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.173996e-01	0.663
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.286642e-01	0.891
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.913159e-01	0.718
Translation	R-HSA-72766	1.400011e-01	0.854
Signal transduction by L1	R-HSA-445144	1.327818e-01	0.877
ER-Phagosome pathway	R-HSA-1236974	1.718252e-01	0.765
Neurexins and neuroligins	R-HSA-6794361	1.977887e-01	0.704
DNA Replication	R-HSA-69306	1.124517e-01	0.949
TCF dependent signaling in response to WNT	R-HSA-201681	1.442618e-01	0.841
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.292804e-01	0.888
Signaling by NOTCH1	R-HSA-1980143	1.942988e-01	0.712
Ion homeostasis	R-HSA-5578775	1.532379e-01	0.815
Signal attenuation	R-HSA-74749	1.638795e-01	0.785
Asymmetric localization of PCP proteins	R-HSA-4608870	1.197577e-01	0.922
Signaling by WNT	R-HSA-195721	1.688666e-01	0.772
Cellular response to chemical stress	R-HSA-9711123	1.130498e-01	0.947
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.550601e-01	0.809
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.924597e-01	0.716
Inhibition of PKR	R-HSA-169131	1.924597e-01	0.716
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.356388e-01	0.868
Basigin interactions	R-HSA-210991	1.488753e-01	0.827
Regulation of FZD by ubiquitination	R-HSA-4641263	2.110577e-01	0.676
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.538633e-01	0.813
Regulation of necroptotic cell death	R-HSA-5675482	1.286642e-01	0.891
Signaling by Nuclear Receptors	R-HSA-9006931	1.496448e-01	0.825
Protein methylation	R-HSA-8876725	1.483380e-01	0.829
The NLRP3 inflammasome	R-HSA-844456	1.175235e-01	0.930
Regulation of CDH11 gene transcription	R-HSA-9762293	1.388142e-01	0.858
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	1.893418e-01	0.723
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.317941e-01	0.880
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.603545e-01	0.795
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.755556e-01	0.756
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.204527e-01	0.919
Iron uptake and transport	R-HSA-917937	1.841004e-01	0.735
G1 Phase	R-HSA-69236	1.973721e-01	0.705
Cyclin D associated events in G1	R-HSA-69231	1.973721e-01	0.705
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.102707e-01	0.677
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.102707e-01	0.677
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.954903e-01	0.709
PCP/CE pathway	R-HSA-4086400	2.154368e-01	0.667
Reproduction	R-HSA-1474165	1.097671e-01	0.960
DAG and IP3 signaling	R-HSA-1489509	2.109597e-01	0.676
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.726738e-01	0.763
Inflammasomes	R-HSA-622312	1.603545e-01	0.795
Signal regulatory protein family interactions	R-HSA-391160	1.292804e-01	0.888
Transport to the Golgi and subsequent modification	R-HSA-948021	1.139948e-01	0.943
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.286642e-01	0.891
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.672560e-01	0.777
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	2.075425e-01	0.683
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.388142e-01	0.858
Assembly Of The HIV Virion	R-HSA-175474	1.657453e-01	0.781
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.532379e-01	0.815
RMTs methylate histone arginines	R-HSA-3214858	1.973721e-01	0.705
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.657453e-01	0.781
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.457545e-01	0.836
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.893418e-01	0.723
Inositol phosphate metabolism	R-HSA-1483249	1.823657e-01	0.739
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.755556e-01	0.756
Signaling by PDGFR in disease	R-HSA-9671555	1.657453e-01	0.781
IRE1alpha activates chaperones	R-HSA-381070	1.307238e-01	0.884
Regulation of BACH1 activity	R-HSA-9708530	1.683963e-01	0.774
Glycogen storage diseases	R-HSA-3229121	2.110577e-01	0.676
Assembly of Viral Components at the Budding Site	R-HSA-168316	1.726738e-01	0.763
Antigen processing-Cross presentation	R-HSA-1236975	2.204172e-01	0.657
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.243353e-01	0.649
Diseases of DNA repair	R-HSA-9675135	2.248962e-01	0.648
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.254495e-01	0.647
Signaling by ALK	R-HSA-201556	2.254495e-01	0.647
Sensory processing of sound	R-HSA-9659379	2.263549e-01	0.645
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.288837e-01	0.640
Hedgehog 'on' state	R-HSA-5632684	2.299682e-01	0.638
RNA Polymerase III Transcription Termination	R-HSA-73980	2.334266e-01	0.632
GAB1 signalosome	R-HSA-180292	2.334266e-01	0.632
Platelet sensitization by LDL	R-HSA-432142	2.334266e-01	0.632
Nuclear signaling by ERBB4	R-HSA-1251985	2.409922e-01	0.618
G-protein beta:gamma signalling	R-HSA-397795	2.415004e-01	0.617
Integrin signaling	R-HSA-354192	2.415004e-01	0.617
Nuclear RNA decay	R-HSA-9930044	2.415004e-01	0.617
FGFR1 mutant receptor activation	R-HSA-1839124	2.415004e-01	0.617
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.415004e-01	0.617
Polymerase switching	R-HSA-69091	2.453786e-01	0.610
Leading Strand Synthesis	R-HSA-69109	2.453786e-01	0.610
Scavenging by Class F Receptors	R-HSA-3000484	2.453786e-01	0.610
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.500011e-01	0.602
STAT5 Activation	R-HSA-9645135	2.502136e-01	0.602
Autointegration results in viral DNA circles	R-HSA-177539	2.502136e-01	0.602
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	2.502136e-01	0.602
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	2.502136e-01	0.602
CREB phosphorylation	R-HSA-199920	2.502136e-01	0.602
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.502136e-01	0.602
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.502136e-01	0.602
Neurofascin interactions	R-HSA-447043	2.502136e-01	0.602
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.502136e-01	0.602
Toll-like Receptor Cascades	R-HSA-168898	2.515871e-01	0.599
Gluconeogenesis	R-HSA-70263	2.537106e-01	0.596
Germ layer formation at gastrulation	R-HSA-9754189	2.563316e-01	0.591
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.563316e-01	0.591
STING mediated induction of host immune responses	R-HSA-1834941	2.563316e-01	0.591
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.594306e-01	0.586
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.600195e-01	0.585
Signaling by FGFR1 in disease	R-HSA-5655302	2.730269e-01	0.564
Translation of Structural Proteins	R-HSA-9683701	2.730269e-01	0.564
CD28 dependent Vav1 pathway	R-HSA-389359	2.738736e-01	0.562
Frs2-mediated activation	R-HSA-170968	2.738736e-01	0.562
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.743252e-01	0.562
NFG and proNGF binds to p75NTR	R-HSA-205017	2.743252e-01	0.562
Interactions of Tat with host cellular proteins	R-HSA-176034	2.743252e-01	0.562
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.743252e-01	0.562
TRAF3 deficiency - HSE	R-HSA-5602571	2.743252e-01	0.562
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.743252e-01	0.562
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.743252e-01	0.562
PTEN Loss of Function in Cancer	R-HSA-5674404	2.743252e-01	0.562
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.743252e-01	0.562
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.743252e-01	0.562
Signaling by TCF7L2 mutants	R-HSA-5339700	2.743252e-01	0.562
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.743252e-01	0.562
Transport of connexins along the secretory pathway	R-HSA-190827	2.743252e-01	0.562
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.743252e-01	0.562
Oligomerization of connexins into connexons	R-HSA-190704	2.743252e-01	0.562
Signaling by NOTCH2	R-HSA-1980145	2.768978e-01	0.558
NOD1/2 Signaling Pathway	R-HSA-168638	2.768978e-01	0.558
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.768978e-01	0.558
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	2.795437e-01	0.554
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.795437e-01	0.554
Insulin processing	R-HSA-264876	2.795437e-01	0.554
VxPx cargo-targeting to cilium	R-HSA-5620916	2.796583e-01	0.553
Co-inhibition by CTLA4	R-HSA-389513	2.796583e-01	0.553
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.796583e-01	0.553
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.796583e-01	0.553
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.796583e-01	0.553
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.796583e-01	0.553
Glycogen synthesis	R-HSA-3322077	2.796583e-01	0.553
Chromosome Maintenance	R-HSA-73886	2.815891e-01	0.550
MECP2 regulates transcription factors	R-HSA-9022707	2.895196e-01	0.538
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.895196e-01	0.538
SOS-mediated signalling	R-HSA-112412	2.895196e-01	0.538
Disinhibition of SNARE formation	R-HSA-114516	2.895196e-01	0.538
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.895196e-01	0.538
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.895196e-01	0.538
CHL1 interactions	R-HSA-447041	2.895196e-01	0.538
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.895196e-01	0.538
HATs acetylate histones	R-HSA-3214847	2.925674e-01	0.534
FOXO-mediated transcription	R-HSA-9614085	2.925674e-01	0.534
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.939169e-01	0.532
Signalling to ERKs	R-HSA-187687	2.950313e-01	0.530
Protein-protein interactions at synapses	R-HSA-6794362	2.959966e-01	0.529
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.988715e-01	0.525
Phase 0 - rapid depolarisation	R-HSA-5576892	2.999493e-01	0.523
CRMPs in Sema3A signaling	R-HSA-399956	3.026811e-01	0.519
Early Phase of HIV Life Cycle	R-HSA-162594	3.032958e-01	0.518
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.032958e-01	0.518
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.032958e-01	0.518
Response of Mtb to phagocytosis	R-HSA-9637690	3.060838e-01	0.514
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.061774e-01	0.514
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.061774e-01	0.514
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.061774e-01	0.514
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.061774e-01	0.514
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.061774e-01	0.514
ABC transporter disorders	R-HSA-5619084	3.166480e-01	0.499
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.204709e-01	0.494
mRNA Capping	R-HSA-72086	3.205781e-01	0.494
Platelet calcium homeostasis	R-HSA-418360	3.205781e-01	0.494
PLC beta mediated events	R-HSA-112043	3.206716e-01	0.494
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.206716e-01	0.494
Circadian clock	R-HSA-9909396	3.232052e-01	0.491
Ribavirin ADME	R-HSA-9755088	3.271377e-01	0.485
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.271377e-01	0.485
Activated NTRK2 signals through FYN	R-HSA-9032500	3.285652e-01	0.483
Signaling by MRAS-complex mutants	R-HSA-9660537	3.285652e-01	0.483
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.285652e-01	0.483
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	3.285652e-01	0.483
ROBO receptors bind AKAP5	R-HSA-9010642	3.285652e-01	0.483
Adrenoceptors	R-HSA-390696	3.285652e-01	0.483
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.285652e-01	0.483
Amino acids regulate mTORC1	R-HSA-9639288	3.299392e-01	0.482
G beta:gamma signalling through BTK	R-HSA-8964315	3.316145e-01	0.479
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.316145e-01	0.479
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.398686e-01	0.469
Signaling by MET	R-HSA-6806834	3.427638e-01	0.465
Signaling by FGFR2	R-HSA-5654738	3.427638e-01	0.465
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.478959e-01	0.459
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.478959e-01	0.459
Signalling to ERK5	R-HSA-198765	3.478959e-01	0.459
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.478959e-01	0.459
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.478959e-01	0.459
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.478959e-01	0.459
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.478959e-01	0.459
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.478959e-01	0.459
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.510831e-01	0.455
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.533773e-01	0.452
Regulation of pyruvate metabolism	R-HSA-9861718	3.569430e-01	0.447
Neutrophil degranulation	R-HSA-6798695	3.585133e-01	0.445
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.605044e-01	0.443
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.629782e-01	0.440
ARMS-mediated activation	R-HSA-170984	3.669997e-01	0.435
Lipophagy	R-HSA-9613354	3.669997e-01	0.435
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.669997e-01	0.435
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.669997e-01	0.435
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.669997e-01	0.435
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.669997e-01	0.435
Calcineurin activates NFAT	R-HSA-2025928	3.669997e-01	0.435
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.669997e-01	0.435
Inactivation of CDC42 and RAC1	R-HSA-428543	3.669997e-01	0.435
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.669997e-01	0.435
Interleukin-1 processing	R-HSA-448706	3.669997e-01	0.435
Respiratory syncytial virus genome replication	R-HSA-9834752	3.669997e-01	0.435
Transcriptional Regulation by E2F6	R-HSA-8953750	3.693222e-01	0.433
RAS processing	R-HSA-9648002	3.693222e-01	0.433
Plasma lipoprotein clearance	R-HSA-8964043	3.693222e-01	0.433
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.750370e-01	0.426
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.750370e-01	0.426
Signaling by FGFR in disease	R-HSA-1226099	3.814120e-01	0.419
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.833613e-01	0.416
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.837577e-01	0.416
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.880986e-01	0.411
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.880986e-01	0.411
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.880986e-01	0.411
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.880986e-01	0.411
Diseases of Immune System	R-HSA-5260271	3.880986e-01	0.411
Glycogen metabolism	R-HSA-8982491	3.880986e-01	0.411
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.891993e-01	0.410
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.891993e-01	0.410
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.891993e-01	0.410
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.933498e-01	0.405
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.951143e-01	0.403
Developmental Cell Lineages	R-HSA-9734767	3.981996e-01	0.400
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	3.989107e-01	0.399
Deadenylation of mRNA	R-HSA-429947	3.989107e-01	0.399
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.989107e-01	0.399
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	3.989107e-01	0.399
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.033935e-01	0.394
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.040070e-01	0.394
Binding and entry of HIV virion	R-HSA-173107	4.045458e-01	0.393
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.045458e-01	0.393
MET activates RAP1 and RAC1	R-HSA-8875555	4.045458e-01	0.393
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.045458e-01	0.393
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.045458e-01	0.393
EGFR Transactivation by Gastrin	R-HSA-2179392	4.045458e-01	0.393
PI3K/AKT activation	R-HSA-198203	4.045458e-01	0.393
2-LTR circle formation	R-HSA-164843	4.045458e-01	0.393
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.045458e-01	0.393
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.045458e-01	0.393
Signaling by Leptin	R-HSA-2586552	4.045458e-01	0.393
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.068671e-01	0.391
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.068671e-01	0.391
G-protein mediated events	R-HSA-112040	4.096332e-01	0.388
Signaling by NTRKs	R-HSA-166520	4.134175e-01	0.384
Axonal growth stimulation	R-HSA-209563	4.140117e-01	0.383
Defective ABCC2 causes DJS	R-HSA-5679001	4.140117e-01	0.383
MET activates PTPN11	R-HSA-8865999	4.140117e-01	0.383
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.140117e-01	0.383
MET activates STAT3	R-HSA-8875791	4.140117e-01	0.383
Intracellular oxygen transport	R-HSA-8981607	4.140117e-01	0.383
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.140117e-01	0.383
Histamine receptors	R-HSA-390650	4.140117e-01	0.383
The NLRP1 inflammasome	R-HSA-844455	4.140117e-01	0.383
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.175646e-01	0.379
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.175646e-01	0.379
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.175646e-01	0.379
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.175646e-01	0.379
Specification of primordial germ cells	R-HSA-9827857	4.175646e-01	0.379
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.226226e-01	0.374
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.226226e-01	0.374
Tight junction interactions	R-HSA-420029	4.226226e-01	0.374
Gastrulation	R-HSA-9758941	4.234600e-01	0.373
Translation of Structural Proteins	R-HSA-9694635	4.237307e-01	0.373
Deadenylation-dependent mRNA decay	R-HSA-429914	4.252498e-01	0.371
Hemostasis	R-HSA-109582	4.292475e-01	0.367
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.395067e-01	0.357
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.409887e-01	0.356
Formation of the posterior neural plate	R-HSA-9832991	4.409887e-01	0.356
Synthesis of PI	R-HSA-1483226	4.409887e-01	0.356
Ionotropic activity of kainate receptors	R-HSA-451306	4.409887e-01	0.356
vRNP Assembly	R-HSA-192905	4.409887e-01	0.356
Bicarbonate transporters	R-HSA-425381	4.409887e-01	0.356
ChREBP activates metabolic gene expression	R-HSA-163765	4.409887e-01	0.356
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.454276e-01	0.351
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.454829e-01	0.351
Mismatch Repair	R-HSA-5358508	4.454829e-01	0.351
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.454829e-01	0.351
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.460976e-01	0.351
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.460976e-01	0.351
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.460976e-01	0.351
Suppression of phagosomal maturation	R-HSA-9637687	4.460976e-01	0.351
Opioid Signalling	R-HSA-111885	4.573462e-01	0.340
Signaling by FGFR4	R-HSA-5654743	4.627185e-01	0.335
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.692678e-01	0.329
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.692678e-01	0.329
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.704600e-01	0.327
NCAM signaling for neurite out-growth	R-HSA-375165	4.727617e-01	0.325
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.728524e-01	0.325
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.728524e-01	0.325
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.728524e-01	0.325
Rap1 signalling	R-HSA-392517	4.728524e-01	0.325
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.734276e-01	0.325
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.734276e-01	0.325
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	4.734276e-01	0.325
Nucleotide catabolism defects	R-HSA-9735786	4.734276e-01	0.325
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.734276e-01	0.325
Defective LFNG causes SCDO3	R-HSA-5083630	4.734276e-01	0.325
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.734276e-01	0.325
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.734276e-01	0.325
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.734276e-01	0.325
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.734276e-01	0.325
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.734276e-01	0.325
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	4.734276e-01	0.325
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.761662e-01	0.322
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.761662e-01	0.322
PI3K events in ERBB4 signaling	R-HSA-1250342	4.761662e-01	0.322
Signaling by GSK3beta mutants	R-HSA-5339716	4.761662e-01	0.322
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.761662e-01	0.322
Activation of RAC1	R-HSA-428540	4.761662e-01	0.322
Neuronal System	R-HSA-112316	4.778761e-01	0.321
Selenoamino acid metabolism	R-HSA-2408522	4.806632e-01	0.318
Proteasome assembly	R-HSA-9907900	4.810594e-01	0.318
Telomere Maintenance	R-HSA-157579	4.854236e-01	0.314
Lysosome Vesicle Biogenesis	R-HSA-432720	4.860907e-01	0.313
G1/S-Specific Transcription	R-HSA-69205	4.860907e-01	0.313
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	4.920721e-01	0.308
Activation of kainate receptors upon glutamate binding	R-HSA-451326	4.920721e-01	0.308
Post-translational protein modification	R-HSA-597592	4.973940e-01	0.303
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.992054e-01	0.302
Nucleosome assembly	R-HSA-774815	4.992054e-01	0.302
Signaling by FGFR3	R-HSA-5654741	4.992054e-01	0.302
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.995866e-01	0.301
Common Pathway of Fibrin Clot Formation	R-HSA-140875	4.995866e-01	0.301
TRAF6 mediated IRF7 activation	R-HSA-933541	5.060270e-01	0.296
Pervasive developmental disorders	R-HSA-9005895	5.099604e-01	0.292
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.099604e-01	0.292
Disorders of Nervous System Development	R-HSA-9697154	5.099604e-01	0.292
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.099604e-01	0.292
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.099604e-01	0.292
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.099604e-01	0.292
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.099604e-01	0.292
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.099604e-01	0.292
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.099604e-01	0.292
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.099604e-01	0.292
Lagging Strand Synthesis	R-HSA-69186	5.256133e-01	0.279
ERK/MAPK targets	R-HSA-198753	5.256133e-01	0.279
G-protein activation	R-HSA-202040	5.256133e-01	0.279
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.256133e-01	0.279
MET promotes cell motility	R-HSA-8875878	5.256481e-01	0.279
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.256481e-01	0.279
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.268222e-01	0.278
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.268222e-01	0.278
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.268222e-01	0.278
NTRK2 activates RAC1	R-HSA-9032759	5.268222e-01	0.278
G2 Phase	R-HSA-68911	5.268222e-01	0.278
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.268222e-01	0.278
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.268222e-01	0.278
Activation of AKT2	R-HSA-165158	5.268222e-01	0.278
Muscarinic acetylcholine receptors	R-HSA-390648	5.268222e-01	0.278
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.268222e-01	0.278
Nectin/Necl trans heterodimerization	R-HSA-420597	5.268222e-01	0.278
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.268222e-01	0.278
Reelin signalling pathway	R-HSA-8866376	5.268222e-01	0.278
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.268222e-01	0.278
Co-inhibition by BTLA	R-HSA-9927353	5.268222e-01	0.278
Extra-nuclear estrogen signaling	R-HSA-9009391	5.353492e-01	0.271
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.363723e-01	0.271
Formation of axial mesoderm	R-HSA-9796292	5.422901e-01	0.266
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	5.422901e-01	0.266
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.422901e-01	0.266
Maturation of nucleoprotein	R-HSA-9683610	5.422901e-01	0.266
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.422901e-01	0.266
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.449200e-01	0.264
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.449200e-01	0.264
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.449200e-01	0.264
Ion channel transport	R-HSA-983712	5.483995e-01	0.261
Serine metabolism	R-HSA-977347	5.508730e-01	0.259
NGF-stimulated transcription	R-HSA-9031628	5.521798e-01	0.258
C-type lectin receptors (CLRs)	R-HSA-5621481	5.573906e-01	0.254
Protein localization	R-HSA-9609507	5.575559e-01	0.254
Molecules associated with elastic fibres	R-HSA-2129379	5.577790e-01	0.254
Regulated Necrosis	R-HSA-5218859	5.643632e-01	0.248
Integrin cell surface interactions	R-HSA-216083	5.696703e-01	0.244
Removal of the Flap Intermediate	R-HSA-69166	5.731049e-01	0.242
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.731049e-01	0.242
Extension of Telomeres	R-HSA-180786	5.742847e-01	0.241
Peroxisomal protein import	R-HSA-9033241	5.742847e-01	0.241
Plus-strand DNA synthesis	R-HSA-164525	5.748054e-01	0.240
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.748054e-01	0.240
Phosphorylation of Emi1	R-HSA-176417	5.748054e-01	0.240
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.748054e-01	0.240
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.748054e-01	0.240
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.748054e-01	0.240
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	5.748054e-01	0.240
PKB-mediated events	R-HSA-109703	5.748054e-01	0.240
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.748054e-01	0.240
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.748054e-01	0.240
CDC6 association with the ORC:origin complex	R-HSA-68689	5.748054e-01	0.240
PDE3B signalling	R-HSA-165160	5.748054e-01	0.240
Ceramide signalling	R-HSA-193681	5.748054e-01	0.240
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.748054e-01	0.240
CLEC7A/inflammasome pathway	R-HSA-5660668	5.748054e-01	0.240
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.748054e-01	0.240
Signaling by KIT in disease	R-HSA-9669938	5.753183e-01	0.240
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	5.753183e-01	0.240
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	5.753183e-01	0.240
Neurotoxicity of clostridium toxins	R-HSA-168799	5.753183e-01	0.240
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.753183e-01	0.240
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.753183e-01	0.240
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.763631e-01	0.239
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.786410e-01	0.238
PI3K Cascade	R-HSA-109704	5.860240e-01	0.232
Diseases of programmed cell death	R-HSA-9645723	5.875393e-01	0.231
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.933373e-01	0.227
Immune System	R-HSA-168256	5.980020e-01	0.223
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.989129e-01	0.223
Growth hormone receptor signaling	R-HSA-982772	5.989129e-01	0.223
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.989287e-01	0.223
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.003528e-01	0.222
Erythropoietin activates RAS	R-HSA-9027284	6.023796e-01	0.220
Beta-catenin phosphorylation cascade	R-HSA-196299	6.023796e-01	0.220
RNA Polymerase III Chain Elongation	R-HSA-73780	6.023796e-01	0.220
Processive synthesis on the lagging strand	R-HSA-69183	6.023796e-01	0.220
p38MAPK events	R-HSA-171007	6.023796e-01	0.220
Formation of the anterior neural plate	R-HSA-9823739	6.023796e-01	0.220
Meiotic recombination	R-HSA-912446	6.024411e-01	0.220
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.059448e-01	0.218
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.101474e-01	0.215
Signaling by FGFR	R-HSA-190236	6.155863e-01	0.211
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.179254e-01	0.209
Signaling by LTK in cancer	R-HSA-9842640	6.179254e-01	0.209
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.179254e-01	0.209
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.179254e-01	0.209
Erythropoietin activates STAT5	R-HSA-9027283	6.179254e-01	0.209
Uncoating of the HIV Virion	R-HSA-162585	6.179254e-01	0.209
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.179254e-01	0.209
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.179254e-01	0.209
MET Receptor Activation	R-HSA-6806942	6.179254e-01	0.209
Abacavir transmembrane transport	R-HSA-2161517	6.179254e-01	0.209
NADPH regeneration	R-HSA-389542	6.179254e-01	0.209
Leukotriene receptors	R-HSA-391906	6.179254e-01	0.209
HDL clearance	R-HSA-8964011	6.179254e-01	0.209
VLDL assembly	R-HSA-8866423	6.179254e-01	0.209
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.179580e-01	0.209
Uptake and actions of bacterial toxins	R-HSA-5339562	6.184987e-01	0.209
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.186177e-01	0.209
Resolution of D-Loop Structures	R-HSA-5693537	6.186177e-01	0.209
Glucagon signaling in metabolic regulation	R-HSA-163359	6.186177e-01	0.209
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.186177e-01	0.209
Mitochondrial protein import	R-HSA-1268020	6.197151e-01	0.208
Heme signaling	R-HSA-9707616	6.197151e-01	0.208
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.216301e-01	0.206
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.216301e-01	0.206
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.301096e-01	0.201
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.301096e-01	0.201
Activation of SMO	R-HSA-5635838	6.301096e-01	0.201
Class I peroxisomal membrane protein import	R-HSA-9603798	6.301096e-01	0.201
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.301096e-01	0.201
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.301096e-01	0.201
Atorvastatin ADME	R-HSA-9754706	6.301096e-01	0.201
Virus Assembly and Release	R-HSA-168268	6.301096e-01	0.201
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.360300e-01	0.197
Signal amplification	R-HSA-392518	6.376890e-01	0.195
Acyl chain remodelling of PS	R-HSA-1482801	6.434522e-01	0.191
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.434522e-01	0.191
HDMs demethylate histones	R-HSA-3214842	6.434522e-01	0.191
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	6.434522e-01	0.191
Insulin receptor signalling cascade	R-HSA-74751	6.484687e-01	0.188
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.493388e-01	0.188
Netrin-1 signaling	R-HSA-373752	6.517534e-01	0.186
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.563071e-01	0.183
Acetylcholine regulates insulin secretion	R-HSA-399997	6.563071e-01	0.183
MET activates PI3K/AKT signaling	R-HSA-8851907	6.566747e-01	0.183
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.566747e-01	0.183
TRIF-mediated programmed cell death	R-HSA-2562578	6.566747e-01	0.183
DAG1 core M1 glycosylations	R-HSA-8932506	6.566747e-01	0.183
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.566747e-01	0.183
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.566747e-01	0.183
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.566747e-01	0.183
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.566747e-01	0.183
Opsins	R-HSA-419771	6.566747e-01	0.183
VLDL clearance	R-HSA-8964046	6.566747e-01	0.183
LDL remodeling	R-HSA-8964041	6.566747e-01	0.183
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.566747e-01	0.183
Netrin mediated repulsion signals	R-HSA-418886	6.566747e-01	0.183
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.566747e-01	0.183
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.566747e-01	0.183
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.577220e-01	0.182
Infectious disease	R-HSA-5663205	6.624884e-01	0.179
Transcriptional regulation by RUNX2	R-HSA-8878166	6.631801e-01	0.178
MET activates PTK2 signaling	R-HSA-8874081	6.643693e-01	0.178
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	6.643693e-01	0.178
Somitogenesis	R-HSA-9824272	6.679187e-01	0.175
Signaling by FGFR1	R-HSA-5654736	6.788770e-01	0.168
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.809977e-01	0.167
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.809977e-01	0.167
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.809977e-01	0.167
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.809977e-01	0.167
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.835837e-01	0.165
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.835837e-01	0.165
Cristae formation	R-HSA-8949613	6.843782e-01	0.165
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.843782e-01	0.165
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.843782e-01	0.165
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.865207e-01	0.163
Reverse Transcription of HIV RNA	R-HSA-162589	6.914962e-01	0.160
Minus-strand DNA synthesis	R-HSA-164516	6.914962e-01	0.160
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.914962e-01	0.160
phospho-PLA2 pathway	R-HSA-111995	6.914962e-01	0.160
DAG1 core M2 glycosylations	R-HSA-8932504	6.914962e-01	0.160
MET receptor recycling	R-HSA-8875656	6.914962e-01	0.160
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.914962e-01	0.160
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	6.914962e-01	0.160
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.914962e-01	0.160
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.914962e-01	0.160
TGFBR3 PTM regulation	R-HSA-9839383	6.914962e-01	0.160
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.914962e-01	0.160
Sodium/Proton exchangers	R-HSA-425986	6.914962e-01	0.160
Interleukin-23 signaling	R-HSA-9020933	6.914962e-01	0.160
IRS-mediated signalling	R-HSA-112399	6.929616e-01	0.159
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.938622e-01	0.159
Activation of HOX genes during differentiation	R-HSA-5619507	6.938622e-01	0.159
RSV-host interactions	R-HSA-9833110	6.938622e-01	0.159
Nuclear Receptor transcription pathway	R-HSA-383280	6.986737e-01	0.156
Adipogenesis	R-HSA-9843745	7.023639e-01	0.153
Telomere Extension By Telomerase	R-HSA-171319	7.034822e-01	0.153
G beta:gamma signalling through PLC beta	R-HSA-418217	7.042176e-01	0.152
Polo-like kinase mediated events	R-HSA-156711	7.042176e-01	0.152
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.042176e-01	0.152
PKA activation	R-HSA-163615	7.042176e-01	0.152
Presynaptic function of Kainate receptors	R-HSA-500657	7.042176e-01	0.152
PKA activation in glucagon signalling	R-HSA-164378	7.042176e-01	0.152
Synaptic adhesion-like molecules	R-HSA-8849932	7.042176e-01	0.152
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.042176e-01	0.152
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.066299e-01	0.151
Elastic fibre formation	R-HSA-1566948	7.075689e-01	0.150
Disorders of transmembrane transporters	R-HSA-5619115	7.096373e-01	0.149
Potential therapeutics for SARS	R-HSA-9679191	7.110188e-01	0.148
GPER1 signaling	R-HSA-9634597	7.133920e-01	0.147
Platelet homeostasis	R-HSA-418346	7.143393e-01	0.146
DARPP-32 events	R-HSA-180024	7.216895e-01	0.142
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.227878e-01	0.141
ALK mutants bind TKIs	R-HSA-9700645	7.227878e-01	0.141
p75NTR regulates axonogenesis	R-HSA-193697	7.227878e-01	0.141
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.227878e-01	0.141
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.227878e-01	0.141
Regulation of signaling by NODAL	R-HSA-1433617	7.227878e-01	0.141
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.227878e-01	0.141
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.227878e-01	0.141
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.227878e-01	0.141
Pentose phosphate pathway	R-HSA-71336	7.234146e-01	0.141
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.260110e-01	0.139
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.260110e-01	0.139
Specification of the neural plate border	R-HSA-9834899	7.260110e-01	0.139
Maturation of nucleoprotein	R-HSA-9694631	7.260110e-01	0.139
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.260110e-01	0.139
Neddylation	R-HSA-8951664	7.349116e-01	0.134
ECM proteoglycans	R-HSA-3000178	7.383564e-01	0.132
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.390129e-01	0.131
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.390129e-01	0.131
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.390129e-01	0.131
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.390129e-01	0.131
Mitochondrial biogenesis	R-HSA-1592230	7.410411e-01	0.130
Azathioprine ADME	R-HSA-9748787	7.411586e-01	0.130
IRS-related events triggered by IGF1R	R-HSA-2428928	7.451120e-01	0.128
Formation of paraxial mesoderm	R-HSA-9793380	7.451120e-01	0.128
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.464283e-01	0.127
Creatine metabolism	R-HSA-71288	7.464283e-01	0.127
Protein hydroxylation	R-HSA-9629569	7.464283e-01	0.127
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.497746e-01	0.125
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.509072e-01	0.124
Folding of actin by CCT/TriC	R-HSA-390450	7.509072e-01	0.124
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.509072e-01	0.124
Peptide hormone biosynthesis	R-HSA-209952	7.509072e-01	0.124
Interleukin-27 signaling	R-HSA-9020956	7.509072e-01	0.124
Receptor Mediated Mitophagy	R-HSA-8934903	7.509072e-01	0.124
Maturation of spike protein	R-HSA-9683686	7.509072e-01	0.124
Maturation of spike protein	R-HSA-9694548	7.531705e-01	0.123
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.655245e-01	0.116
Matriglycan biosynthesis on DAG1	R-HSA-9939291	7.655245e-01	0.116
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.655245e-01	0.116
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.655245e-01	0.116
Signalling to RAS	R-HSA-167044	7.655245e-01	0.116
Zygotic genome activation (ZGA)	R-HSA-9819196	7.655245e-01	0.116
RNA Polymerase I Promoter Escape	R-HSA-73772	7.668954e-01	0.115
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.686641e-01	0.114
Signaling by WNT in cancer	R-HSA-4791275	7.710778e-01	0.113
DAG1 core M3 glycosylations	R-HSA-8932505	7.761757e-01	0.110
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.761757e-01	0.110
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.761757e-01	0.110
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.761757e-01	0.110
vRNA Synthesis	R-HSA-192814	7.761757e-01	0.110
Signaling by APC mutants	R-HSA-4839744	7.761757e-01	0.110
Chylomicron assembly	R-HSA-8963888	7.761757e-01	0.110
RHOBTB3 ATPase cycle	R-HSA-9706019	7.761757e-01	0.110
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.761757e-01	0.110
Suppression of apoptosis	R-HSA-9635465	7.761757e-01	0.110
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.761757e-01	0.110
Dissolution of Fibrin Clot	R-HSA-75205	7.761757e-01	0.110
IGF1R signaling cascade	R-HSA-2428924	7.798159e-01	0.108
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.833574e-01	0.106
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.833574e-01	0.106
Cardiogenesis	R-HSA-9733709	7.858616e-01	0.105
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.905569e-01	0.102
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.928258e-01	0.101
tRNA processing	R-HSA-72306	7.930715e-01	0.101
Metabolism of proteins	R-HSA-392499	7.937146e-01	0.100
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.988822e-01	0.098
ERKs are inactivated	R-HSA-202670	7.988822e-01	0.098
Proton-coupled monocarboxylate transport	R-HSA-433692	7.988822e-01	0.098
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.988822e-01	0.098
Plasmalogen biosynthesis	R-HSA-75896	7.988822e-01	0.098
Signaling by AMER1 mutants	R-HSA-4839748	7.988822e-01	0.098
Signaling by AXIN mutants	R-HSA-4839735	7.988822e-01	0.098
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.988822e-01	0.098
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.988822e-01	0.098
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.998452e-01	0.097
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.998452e-01	0.097
Miscellaneous transport and binding events	R-HSA-5223345	7.998452e-01	0.097
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.999868e-01	0.097
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.999868e-01	0.097
G alpha (z) signalling events	R-HSA-418597	8.017845e-01	0.096
Pyruvate metabolism	R-HSA-70268	8.030985e-01	0.095
Amine ligand-binding receptors	R-HSA-375280	8.051856e-01	0.094
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.124540e-01	0.090
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.130548e-01	0.090
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.130548e-01	0.090
Interleukin receptor SHC signaling	R-HSA-912526	8.154732e-01	0.089
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.166999e-01	0.088
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.166999e-01	0.088
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.173139e-01	0.088
MET activates RAS signaling	R-HSA-8851805	8.192864e-01	0.087
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.192864e-01	0.087
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.192864e-01	0.087
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.192864e-01	0.087
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.192864e-01	0.087
GRB2 events in EGFR signaling	R-HSA-179812	8.192864e-01	0.087
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.192864e-01	0.087
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.192864e-01	0.087
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	8.192864e-01	0.087
Signaling by LTK	R-HSA-9842663	8.192864e-01	0.087
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.192864e-01	0.087
RUNX3 regulates p14-ARF	R-HSA-8951936	8.192864e-01	0.087
Regulation of IFNG signaling	R-HSA-877312	8.192864e-01	0.087
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.192864e-01	0.087
Interleukin-15 signaling	R-HSA-8983432	8.192864e-01	0.087
Interleukin-35 Signalling	R-HSA-8984722	8.192864e-01	0.087
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.192864e-01	0.087
OAS antiviral response	R-HSA-8983711	8.192864e-01	0.087
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.197729e-01	0.086
Regulation of insulin secretion	R-HSA-422356	8.215356e-01	0.085
Base Excision Repair	R-HSA-73884	8.284266e-01	0.082
Thromboxane signalling through TP receptor	R-HSA-428930	8.298773e-01	0.081
Complex III assembly	R-HSA-9865881	8.298773e-01	0.081
Mitochondrial RNA degradation	R-HSA-9836573	8.298773e-01	0.081
Plasma lipoprotein assembly	R-HSA-8963898	8.298773e-01	0.081
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.324112e-01	0.080
Amyloid fiber formation	R-HSA-977225	8.366928e-01	0.077
Triglyceride catabolism	R-HSA-163560	8.372629e-01	0.077
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.372629e-01	0.077
FGFR2 mutant receptor activation	R-HSA-1839126	8.372629e-01	0.077
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.376216e-01	0.077
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.376216e-01	0.077
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.376216e-01	0.077
Diseases of nucleotide metabolism	R-HSA-9735804	8.376216e-01	0.077
Platelet Adhesion to exposed collagen	R-HSA-75892	8.376216e-01	0.077
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.376216e-01	0.077
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.376216e-01	0.077
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.376216e-01	0.077
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.380485e-01	0.077
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.432594e-01	0.074
Activation of G protein gated Potassium channels	R-HSA-1296041	8.432594e-01	0.074
G protein gated Potassium channels	R-HSA-1296059	8.432594e-01	0.074
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.432594e-01	0.074
Interleukin-7 signaling	R-HSA-1266695	8.432594e-01	0.074
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.506007e-01	0.070
Signaling by Insulin receptor	R-HSA-74752	8.511414e-01	0.070
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.511414e-01	0.070
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.540975e-01	0.068
Signaling by FGFR4 in disease	R-HSA-5655291	8.540975e-01	0.068
Hydrolysis of LPC	R-HSA-1483115	8.540975e-01	0.068
Retrograde neurotrophin signalling	R-HSA-177504	8.540975e-01	0.068
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.540975e-01	0.068
Malate-aspartate shuttle	R-HSA-9856872	8.540975e-01	0.068
HDL assembly	R-HSA-8963896	8.540975e-01	0.068
Acyl chain remodeling of CL	R-HSA-1482798	8.540975e-01	0.068
Zinc transporters	R-HSA-435354	8.540975e-01	0.068
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.547525e-01	0.068
Parasite infection	R-HSA-9664407	8.547525e-01	0.068
Leishmania phagocytosis	R-HSA-9664417	8.547525e-01	0.068
TRP channels	R-HSA-3295583	8.556784e-01	0.068
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.587154e-01	0.066
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.587154e-01	0.066
Mitochondrial protein degradation	R-HSA-9837999	8.649019e-01	0.063
Disease	R-HSA-1643685	8.659746e-01	0.062
Signaling by FGFR2 in disease	R-HSA-5655253	8.661327e-01	0.062
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.671196e-01	0.062
Signaling by PDGF	R-HSA-186797	8.671196e-01	0.062
Packaging Of Telomere Ends	R-HSA-171306	8.671919e-01	0.062
Maturation of hRSV A proteins	R-HSA-9828806	8.671919e-01	0.062
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.684816e-01	0.061
SHC1 events in EGFR signaling	R-HSA-180336	8.689025e-01	0.061
Protein lipoylation	R-HSA-9857492	8.689025e-01	0.061
Telomere C-strand synthesis initiation	R-HSA-174430	8.689025e-01	0.061
Biotin transport and metabolism	R-HSA-196780	8.689025e-01	0.061
Lysosphingolipid and LPA receptors	R-HSA-419408	8.689025e-01	0.061
DNA Damage Reversal	R-HSA-73942	8.689025e-01	0.061
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.734773e-01	0.059
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.748649e-01	0.058
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.778559e-01	0.057
Asparagine N-linked glycosylation	R-HSA-446203	8.781100e-01	0.056
Activation of the phototransduction cascade	R-HSA-2485179	8.822061e-01	0.054
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.822061e-01	0.054
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.822061e-01	0.054
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.822061e-01	0.054
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.822061e-01	0.054
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.822061e-01	0.054
Killing mechanisms	R-HSA-9664420	8.822061e-01	0.054
Attachment and Entry	R-HSA-9678110	8.822061e-01	0.054
Differentiation of T cells	R-HSA-9945266	8.822061e-01	0.054
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.822061e-01	0.054
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.835865e-01	0.054
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.862402e-01	0.052
SLC transporter disorders	R-HSA-5619102	8.873670e-01	0.052
Signaling by Erythropoietin	R-HSA-9006335	8.877241e-01	0.052
DNA methylation	R-HSA-5334118	8.877241e-01	0.052
Regulation of gene expression in beta cells	R-HSA-210745	8.877241e-01	0.052
Glucagon-type ligand receptors	R-HSA-420092	8.877241e-01	0.052
Integration of energy metabolism	R-HSA-163685	8.906459e-01	0.050
HCMV Late Events	R-HSA-9610379	8.911171e-01	0.050
Rab regulation of trafficking	R-HSA-9007101	8.915919e-01	0.050
Stimuli-sensing channels	R-HSA-2672351	8.928433e-01	0.049
Glycine degradation	R-HSA-6783984	8.941602e-01	0.049
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.941602e-01	0.049
Synthesis of PG	R-HSA-1483148	8.941602e-01	0.049
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.941602e-01	0.049
Scavenging by Class A Receptors	R-HSA-3000480	8.942901e-01	0.049
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.942901e-01	0.049
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.942901e-01	0.049
DAP12 signaling	R-HSA-2424491	8.968481e-01	0.047
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.018243e-01	0.045
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.049019e-01	0.043
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.049019e-01	0.043
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.052774e-01	0.043
Downstream signal transduction	R-HSA-186763	9.052774e-01	0.043
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.056308e-01	0.043
TBC/RABGAPs	R-HSA-8854214	9.088702e-01	0.041
Extracellular matrix organization	R-HSA-1474244	9.108477e-01	0.041
DAG1 glycosylations	R-HSA-8931838	9.130589e-01	0.040
Inwardly rectifying K+ channels	R-HSA-1296065	9.130589e-01	0.040
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.130589e-01	0.040
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.130589e-01	0.040
Cardiac conduction	R-HSA-5576891	9.131754e-01	0.039
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.145540e-01	0.039
Apoptotic factor-mediated response	R-HSA-111471	9.145540e-01	0.039
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.202372e-01	0.036
Cytoprotection by HMOX1	R-HSA-9707564	9.223718e-01	0.035
PI-3K cascade:FGFR3	R-HSA-5654710	9.232269e-01	0.035
Pyrimidine biosynthesis	R-HSA-500753	9.232269e-01	0.035
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.232269e-01	0.035
E2F mediated regulation of DNA replication	R-HSA-113510	9.232269e-01	0.035
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.232269e-01	0.035
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.232269e-01	0.035
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.232269e-01	0.035
Other interleukin signaling	R-HSA-449836	9.232269e-01	0.035
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.266429e-01	0.033
Acyl chain remodelling of PC	R-HSA-1482788	9.268547e-01	0.033
Glutamate and glutamine metabolism	R-HSA-8964539	9.268547e-01	0.033
FCERI mediated NF-kB activation	R-HSA-2871837	9.268888e-01	0.033
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.273380e-01	0.033
PI-3K cascade:FGFR4	R-HSA-5654720	9.310200e-01	0.031
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.310200e-01	0.031
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.310200e-01	0.031
Signaling by NODAL	R-HSA-1181150	9.310200e-01	0.031
Acyl chain remodelling of PI	R-HSA-1482922	9.310200e-01	0.031
Eicosanoid ligand-binding receptors	R-HSA-391903	9.310200e-01	0.031
Metabolism of polyamines	R-HSA-351202	9.315576e-01	0.031
Interferon alpha/beta signaling	R-HSA-909733	9.319255e-01	0.031
eNOS activation	R-HSA-203615	9.329511e-01	0.030
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.329511e-01	0.030
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.329511e-01	0.030
Aquaporin-mediated transport	R-HSA-445717	9.361725e-01	0.029
Metal ion SLC transporters	R-HSA-425410	9.376696e-01	0.028
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.380224e-01	0.028
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.380224e-01	0.028
Acyl chain remodelling of PG	R-HSA-1482925	9.380224e-01	0.028
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.380224e-01	0.028
Transferrin endocytosis and recycling	R-HSA-917977	9.385640e-01	0.028
Acyl chain remodelling of PE	R-HSA-1482839	9.385640e-01	0.028
Peptide hormone metabolism	R-HSA-2980736	9.387048e-01	0.027
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.405030e-01	0.027
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.409650e-01	0.026
PRC2 methylates histones and DNA	R-HSA-212300	9.437288e-01	0.025
GPVI-mediated activation cascade	R-HSA-114604	9.437288e-01	0.025
RUNX2 regulates bone development	R-HSA-8941326	9.437288e-01	0.025
Glycosphingolipid transport	R-HSA-9845576	9.437288e-01	0.025
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.443144e-01	0.025
Androgen biosynthesis	R-HSA-193048	9.443144e-01	0.025
Glucocorticoid biosynthesis	R-HSA-194002	9.443144e-01	0.025
Mitochondrial calcium ion transport	R-HSA-8949215	9.443144e-01	0.025
Attachment and Entry	R-HSA-9694614	9.443144e-01	0.025
Cleavage of the damaged purine	R-HSA-110331	9.484785e-01	0.023
Collagen chain trimerization	R-HSA-8948216	9.484785e-01	0.023
PI-3K cascade:FGFR1	R-HSA-5654689	9.499679e-01	0.022
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.499679e-01	0.022
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.499679e-01	0.022
LDL clearance	R-HSA-8964038	9.499679e-01	0.022
The phototransduction cascade	R-HSA-2514856	9.506433e-01	0.022
Purine salvage	R-HSA-74217	9.528442e-01	0.021
Depurination	R-HSA-73927	9.528442e-01	0.021
Mitochondrial mRNA modification	R-HSA-9937008	9.550478e-01	0.020
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.556263e-01	0.020
Formation of the cornified envelope	R-HSA-6809371	9.580018e-01	0.019
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.596121e-01	0.018
Interleukin-2 family signaling	R-HSA-451927	9.605375e-01	0.017
Leishmania infection	R-HSA-9658195	9.631052e-01	0.016
Parasitic Infection Pathways	R-HSA-9824443	9.631052e-01	0.016
PI-3K cascade:FGFR2	R-HSA-5654695	9.637132e-01	0.016
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.637132e-01	0.016
Hyaluronan degradation	R-HSA-2160916	9.637132e-01	0.016
Formation of the nephric duct	R-HSA-9830364	9.637132e-01	0.016
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.637132e-01	0.016
Laminin interactions	R-HSA-3000157	9.637132e-01	0.016
Paracetamol ADME	R-HSA-9753281	9.640477e-01	0.016
Intra-Golgi traffic	R-HSA-6811438	9.670182e-01	0.015
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.673982e-01	0.014
Urea cycle	R-HSA-70635	9.673982e-01	0.014
Abacavir ADME	R-HSA-2161522	9.673982e-01	0.014
Sphingolipid catabolism	R-HSA-9845614	9.673982e-01	0.014
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.673982e-01	0.014
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.673982e-01	0.014
Cytosolic tRNA aminoacylation	R-HSA-379716	9.698615e-01	0.013
Activation of GABAB receptors	R-HSA-991365	9.698615e-01	0.013
GABA B receptor activation	R-HSA-977444	9.698615e-01	0.013
Cleavage of the damaged pyrimidine	R-HSA-110329	9.698615e-01	0.013
Depyrimidination	R-HSA-73928	9.698615e-01	0.013
RNA Polymerase I Promoter Opening	R-HSA-73728	9.707091e-01	0.013
Signaling by FGFR3 in disease	R-HSA-5655332	9.707091e-01	0.013
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.707091e-01	0.013
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.707091e-01	0.013
Defective pyroptosis	R-HSA-9710421	9.724677e-01	0.012
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.726663e-01	0.012
Diseases of carbohydrate metabolism	R-HSA-5663084	9.732636e-01	0.012
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.736839e-01	0.012
Insulin receptor recycling	R-HSA-77387	9.736839e-01	0.012
Prednisone ADME	R-HSA-9757110	9.736839e-01	0.012
Pyrimidine salvage	R-HSA-73614	9.736839e-01	0.012
Pyroptosis	R-HSA-5620971	9.736839e-01	0.012
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.738262e-01	0.012
Regulation of beta-cell development	R-HSA-186712	9.739664e-01	0.011
Triglyceride metabolism	R-HSA-8979227	9.739664e-01	0.011
Amino acid transport across the plasma membrane	R-HSA-352230	9.739664e-01	0.011
DAP12 interactions	R-HSA-2172127	9.748556e-01	0.011
Surfactant metabolism	R-HSA-5683826	9.748556e-01	0.011
RAB geranylgeranylation	R-HSA-8873719	9.760055e-01	0.011
Downstream signaling of activated FGFR3	R-HSA-5654708	9.763568e-01	0.010
Thyroxine biosynthesis	R-HSA-209968	9.763568e-01	0.010
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.763568e-01	0.010
Collagen degradation	R-HSA-1442490	9.778920e-01	0.010
Downstream signaling of activated FGFR4	R-HSA-5654716	9.787583e-01	0.009
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.787583e-01	0.009
Neurotransmitter clearance	R-HSA-112311	9.787583e-01	0.009
Condensation of Prophase Chromosomes	R-HSA-2299718	9.790450e-01	0.009
Neurotransmitter release cycle	R-HSA-112310	9.802703e-01	0.009
Synthesis of PC	R-HSA-1483191	9.808775e-01	0.008
PI Metabolism	R-HSA-1483255	9.809178e-01	0.008
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.819693e-01	0.008
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.819693e-01	0.008
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.819693e-01	0.008
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.840877e-01	0.007
Chemokine receptors bind chemokines	R-HSA-380108	9.840877e-01	0.007
Recycling of bile acids and salts	R-HSA-159418	9.845965e-01	0.007
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.854897e-01	0.006
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.861615e-01	0.006
Heme degradation	R-HSA-189483	9.861615e-01	0.006
Innate Immune System	R-HSA-168249	9.862187e-01	0.006
Collagen formation	R-HSA-1474290	9.862416e-01	0.006
SLC-mediated transport of amino acids	R-HSA-9958863	9.865607e-01	0.006
Complex IV assembly	R-HSA-9864848	9.867713e-01	0.006
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.875675e-01	0.005
Hyaluronan metabolism	R-HSA-2142845	9.875675e-01	0.005
RA biosynthesis pathway	R-HSA-5365859	9.875675e-01	0.005
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.875675e-01	0.005
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.876431e-01	0.005
Downstream signaling of activated FGFR2	R-HSA-5654696	9.888308e-01	0.005
Downstream signaling of activated FGFR1	R-HSA-5654687	9.888308e-01	0.005
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.888308e-01	0.005
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.888308e-01	0.005
Nucleotide biosynthesis	R-HSA-8956320	9.890120e-01	0.005
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.893101e-01	0.005
COPII-mediated vesicle transport	R-HSA-204005	9.895619e-01	0.005
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.899889e-01	0.004
Voltage gated Potassium channels	R-HSA-1296072	9.909854e-01	0.004
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.909854e-01	0.004
NCAM1 interactions	R-HSA-419037	9.909854e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.909854e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.909854e-01	0.004
Interferon gamma signaling	R-HSA-877300	9.910024e-01	0.004
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.934641e-01	0.003
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.934641e-01	0.003
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.941285e-01	0.003
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.941285e-01	0.003
Aflatoxin activation and detoxification	R-HSA-5423646	9.941285e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.942972e-01	0.002
GABA receptor activation	R-HSA-977443	9.942972e-01	0.002
Nucleotide salvage	R-HSA-8956321	9.948111e-01	0.002
Endogenous sterols	R-HSA-211976	9.948111e-01	0.002
FCGR activation	R-HSA-2029481	9.952078e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.952078e-01	0.002
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.954624e-01	0.002
Degradation of the extracellular matrix	R-HSA-1474228	9.956184e-01	0.002
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.961760e-01	0.002
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.965648e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.974194e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.975098e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.977976e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.979991e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.979991e-01	0.001
Cytosolic sulfonation of small molecules	R-HSA-156584	9.981950e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.982374e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.983210e-01	0.001
Aspirin ADME	R-HSA-9749641	9.983492e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.985008e-01	0.001
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.985670e-01	0.001
Leishmania parasite growth and survival	R-HSA-9664433	9.985670e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.989443e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.989816e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.990115e-01	0.000
Synthesis of PA	R-HSA-1483166	9.990518e-01	0.000
Dectin-2 family	R-HSA-5621480	9.990518e-01	0.000
Potassium Channels	R-HSA-1296071	9.991812e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.992815e-01	0.000
PPARA activates gene expression	R-HSA-1989781	9.992910e-01	0.000
Glutathione conjugation	R-HSA-156590	9.993128e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.993128e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.993761e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.993998e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.995020e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.995527e-01	0.000
Xenobiotics	R-HSA-211981	9.995527e-01	0.000
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.996391e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.996759e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.996759e-01	0.000
Kidney development	R-HSA-9830369	9.996759e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.996759e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.997307e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.997651e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.997890e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.997890e-01	0.000
Transport of small molecules	R-HSA-382551	9.997892e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.998034e-01	0.000
Purine catabolism	R-HSA-74259	9.998105e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.998106e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.998274e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.998472e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.998627e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998699e-01	0.000
Keratinization	R-HSA-6805567	9.998747e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998784e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.998812e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999005e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999177e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999280e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999468e-01	0.000
Drug ADME	R-HSA-9748784	9.999492e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999617e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999704e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999712e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999776e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999826e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999855e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999858e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999871e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999896e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999916e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999935e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999951e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999977e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999977e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999988e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999990e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999991e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999994e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999995e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999996e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999997e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999997e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999998e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999999e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000