ALK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y1062 Sugiyama POTEF A26C1B GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O00592 T556 Sugiyama PODXL PCLP PCLP1 DsWIVPLDNLTKDDLDEEEDtHL__________________
O15067 S530 Sugiyama PFAS KIAA0361 PICsLHDQGAGGNGNVLKELsDPAGAIIytsRFQLGDPTLN
O15427 S464 Sugiyama SLC16A3 MCT3 MCT4 EHFLKAEPEKNGEVVHtPEtsV___________________
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390 T137 Sugiyama HNRNPR HNRPR ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43396 T117 Sugiyama TXNL1 TRP32 TXL TXNL VGLEEKIKQHLENDPGsNEDtDIPKGYMDLMPFINKAGCEC
O43615 S94 Sugiyama TIMM44 MIMT44 TIM44 NKEMKESIKKFRDEARRLEEsDVLQEARRKyKtIESETVRT
O43823 T681 Sugiyama AKAP8 AKAP95 ESAQTRVAPAPAAADAEVEQtDAEsKDAVPTE_________
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60220 S96 Sugiyama TIMM8A DDP DDP1 TIM8A FILNRLEQTQKSKPVFSEsLsD___________________
O60231 S107 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 ARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKH
O60271 S813 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 LCIASVPGARETDYPAGEDLsEsGQVDKASLCGSMTSNSSA
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506 T134 Sugiyama SYNCRIP HNRPQ NSAP1 DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60664 T145 Sugiyama PLIN3 M6PRBP1 TIP47 VssKVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKT
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60927 S74 Sugiyama PPP1R11 HCGV TCTE5 GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O75400 S938 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 SPKKKtGKDsGNWDtsGsELsEGELEKRRRtLLEQLDDDQ_
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75822 S127 Sugiyama EIF3J EIF3S1 PRO0391 VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95551 T88 GPS6|SIGNOR|EPSD|PSP TDP2 EAP2 TTRAP AD-022 ESALERRPETISEPKTyVDLtNEEtTDsttsKISPSEDTQQ
O95551 T92 GPS6|SIGNOR|EPSD|PSP TDP2 EAP2 TTRAP AD-022 ERRPETISEPKTyVDLtNEEtTDsttsKISPSEDTQQENGS
O95831 S116 Sugiyama AIFM1 AIF PDCD8 NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00505 S118 Sugiyama GOT2 KYAT4 PIGGLAEFCKASAELALGENsEVLKSGRFVTVQTIsGtGAL
P00558 S390 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T376 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG
P00558 T378 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGGGA
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T119 Sugiyama ALDOA ALDA KsKGGVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYK
P04075 T123 Sugiyama ALDOA ALDA GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T52 Sugiyama ALDOA ALDA AADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDRVNP
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04083 T169 Sugiyama ANXA1 ANX1 LPC1 IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S304 Sugiyama RPLP0 AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05455 S83 Sugiyama SSB TDFNVIVEALSKSKAELMEIsEDKTKIRRsPsKPLPEVTDE
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 S37 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733 S40 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S390 Sugiyama PGK2 PGKB VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07900 S164 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGT
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S159 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGT
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09104 S37 Sugiyama ENO2 NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104 T41 Sugiyama ENO2 EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG38 Y1062 Sugiyama POTEI GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 Y1025 Sugiyama POTEJ GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P10599 T100 Sugiyama TXN TRDX TRX TRX1 FKKGQKVGEFSGANKEKLEAtINELV_______________
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P10809 S67 Sugiyama HSPD1 HSP60 LADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLK
P10809 T105 Sugiyama HSPD1 HSP60 DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12004 S261 Sugiyama PCNA IADMGHLKyyLAPKIEDEEGs____________________
P12956 S27 Sugiyama XRCC6 G22P1 YYKtEGDEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKA
P12956 S560 Sugiyama XRCC6 G22P1 VtKRKHDNEGSGSKRPKVEysEEELKTHISKGTLGKFTVPM
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13797 S113 Sugiyama PLS3 FRKAINRKEGICALGGTsELssEGtQHsysEEEKyAFVNWI
P13798 S185 Sugiyama APEH D3F15S2 D3S48E DNF15S2 VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P13929 S37 Sugiyama ENO3 NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929 T41 Sugiyama ENO3 EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P14314 T103 Sugiyama PRKCSH G19P1 KPLyIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKE
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618 T409 Sugiyama PKM OIP3 PK2 PK3 PKM2 IyHLQLFEELRRLAPITsDPtEAtAVGAVEAsFKCCsGAII
P14618 T412 Sugiyama PKM OIP3 PK2 PK3 PKM2 LQLFEELRRLAPITsDPtEAtAVGAVEAsFKCCsGAIIVLT
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S306 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TETVEEPMEEEEAAKEEKEEsDDEAAVEEEEEEKKPKTKKV
P14625 S439 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TDDFHDMMPKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKV
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P17096 S103 Sugiyama HMGA1 HMGIY PRGRPKKLEKEEEEGIsQEssEEEQ________________
P17812 S578 Sugiyama CTPS1 CTPS GCRLsPRDtysDRsGsssPDsEItELKFPsINHD_______
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20042 T111 Sugiyama EIF2S2 EIF2B IDEAEEGVKDLKIEsDVQEPtEPEDDLDIMLGNKKKKKKNV
P20618 Y158 Sugiyama PSMB1 PSC5 IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24386 S652 Sugiyama CHM REP1 TCD PEANSETFKESTNLGNLEEssE___________________
P25705 S52 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM AARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETG
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25705 S65 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348 S37 Sugiyama YWHAQ ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348 T141 Sugiyama YWHAQ MKGDYFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQ
P27816 S1151 Sugiyama MAP4 LSGGGDQREAQtLDsQIQEtsI___________________
P27816 S643 Sugiyama MAP4 IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31153 S38 Sugiyama MAT2A AMS2 MATA2 FLFTSESVGEGHPDKICDQIsDAVLDAHLQQDPDAKVACET
P31946 S39 Sugiyama YWHAB ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31948 S459 Sugiyama STIP1 EAMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRH
P31948 S460 Sugiyama STIP1 AMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRHD
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 S415 Sugiyama HSPA4 APG2 HSPH2 TDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTFy
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35269 S218 Sugiyama GTF2F1 RAP74 GRRKASELRIHDLEDDLEMssDAsDAsGEEGGRVPKAKKKA
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35659 S231 Sugiyama DEK SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P35659 S306 Sugiyama DEK DSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDEELK
P36871 S477 Sugiyama PGM1 KQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDG
P36896 S168 Sugiyama ACVR1B ACVRLK4 ALK4 VINYHQRVYHNRQRLDMEDPsCEMCLsKDKTLQDLVYDLST
P36896 S174 Sugiyama ACVR1B ACVRLK4 ALK4 RVYHNRQRLDMEDPsCEMCLsKDKTLQDLVYDLSTSGSGSG
P36896 S498 Sugiyama ACVR1B ACVRLK4 ALK4 YANGAARLTALRIKKTLSQLsVQEDVKI_____________
P36896 T364 Sugiyama ACVR1B ACVRLK4 ALK4 KKNGMCAIADLGLAVRHDAVtDtIDIAPNQRVGTKRyMAPE
P36896 T366 Sugiyama ACVR1B ACVRLK4 ALK4 NGMCAIADLGLAVRHDAVtDtIDIAPNQRVGTKRyMAPEVL
P36896 T389 Sugiyama ACVR1B ACVRLK4 ALK4 IAPNQRVGTKRyMAPEVLDEtINMKHFDSFKCADIYALGLV
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T480 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 RNTTIPTKKSQVFstAADGQtQVEIKVCQGEREMAGDNKLL
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43121 T299 Sugiyama MCAM MUC18 PPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRYE
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P45974 S785 Sugiyama USP5 ISOT DLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQLFA
P46063 S53 Sugiyama RECQL RECQ1 RECQL1 QELIQKKKVLTKKIKQCLEDsDAGAsNEyDssPAAWNKEDF
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P48643 S539 Sugiyama CCT5 CCTE KIAA0098 LATQMVRMILKIDDIRKPGEsEE__________________
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P49321 S432 Sugiyama NASP EKVRAKLVPsQEEtKLsVEEsEAAGDGVDTKVAQGAtEKsP
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49589 S305 Sugiyama CARS1 CARS KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49589 S307 Sugiyama CARS1 CARS VPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASK
P50502 S79 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 KPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDAPQEM
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54105 S102 Sugiyama CLNS1A CLCI ICLN VNAKFEEEsKEPVADEEEEDsDDDVEPITEFRFVPSDKSAL
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60228 S442 Sugiyama EIF3E EIF3S6 INT6 IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T303 Sugiyama ACTB MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y362 Sugiyama ACTB GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61604 S21 Sugiyama HSPE1 MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 S77 Sugiyama HNRNPK HNRPK VIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIETI
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S145 Sugiyama YWHAZ YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T232 Sugiyama YWHAZ KDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_______
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63146 S148 Sugiyama UBE2B RAD6B UBCH1 QLYQENKREYEKRVsAIVEQsWNDS________________
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T303 Sugiyama ACTG1 ACTG MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y362 Sugiyama ACTG1 ACTG GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S314 Sugiyama YBX1 NSEP1 YB1 NPKPQDGKETKAADPPAENssAPEAEQGGAE__________
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y451 Sugiyama TUBA1B DyEEVGVDsVEGEGEEEGEEy____________________
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00341 S35 Sugiyama HDLBP HBP VGL HRSGLVPQQIKVAtLNsEEEsDPPtyKDAFPPLPEKAACLE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q04637 S1430 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q08J23 T733 Sugiyama NSUN2 SAKI TRM4 EGVILtNEsAAstGQPDNDVtEGQRAGEPNsPDAEEANsPD
Q12792 T348 Sugiyama TWF1 PTK9 GPAGKRGIRRLIRGPAEtEAttD__________________
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q12952 S174 Sugiyama FOXL1 FKHL11 FREAC7 AKRPRAETHQRSAEAQPEAGsGAGGSGPAISRLQAAPAGPS
Q13155 S48 Sugiyama AIMP2 JTV1 PRO0992 PNVHGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYE
Q13263 S479 Sugiyama TRIM28 KAP1 RNF96 TIF1B ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13283 S149 Sugiyama G3BP1 G3BP DIFRyQDEVFGGFVtEPQEEsEEEVEEPEERQQtPEVVPDD
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13371 S25 Sugiyama PDCL PHLOP1 PhLP1 DDKLLGEKLQyyysssEDEDsDHEDKDRGRCAPAsssVPAE
Q13404 S146 Sugiyama UBE2V1 CROC1 UBE2V UEV1 P/OKcl.19 RLMMSKENMKLPQPPEGQCysN___________________
Q13428 S765 Sugiyama TCOF1 GKTGPTVTQVKAEKQEDsEssEEEsDSEEAAAsPAQVKTSV
Q13428 S88 Sugiyama TCOF1 DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q13442 S60 Sugiyama PDAP1 HASPP28 QKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGL
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13501 S276 Sugiyama SQSTM1 ORCA OSIL DIDVEHGGKRsRLtPVsPEssstEEKsssQPssCCsDPsKP
Q13501 T278 Sugiyama SQSTM1 ORCA OSIL DVEHGGKRsRLtPVsPEssstEEKsssQPssCCsDPsKPGG
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13547 S421 Sugiyama HDAC1 RPD3L1 PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK
Q13610 S57 Sugiyama PWP1 AEAKEKLQEEGGGsDEEEtGsPsEDGMQsARTQARPREPLE
Q13610 T55 Sugiyama PWP1 LIAEAKEKLQEEGGGsDEEEtGsPsEDGMQsARTQARPREP
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q13765 T119 Sugiyama NACA HSD48 SKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAA
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14257 T137 Sugiyama RCN2 ERC55 VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR
Q14568 S164 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGT
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14677 S164 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 RLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKW
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15527 T190 Sugiyama SURF2 LYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAKPPREKAT
Q15796 S464 iPTMNet SMAD2 MADH2 MADR2 GPLQWLDKVLTQMGsPsVRCssMs_________________
Q15796 S465 iPTMNet SMAD2 MADH2 MADR2 PLQWLDKVLTQMGsPsVRCssMs__________________
Q15796 S467 iPTMNet SMAD2 MADH2 MADR2 QWLDKVLTQMGsPsVRCssMs____________________
Q15819 T142 Sugiyama UBE2V2 MMS2 UEV2 LRRLMMSKENMKLPQPPEGQtyNN_________________
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y1062 Sugiyama POTEE A26C1A POTE2 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y451 Sugiyama TUBA1A TUBA3 DyEEVGVDsVEGEGEEEGEEy____________________
Q7Z3K3 S28 Sugiyama POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003 MECEEEELEPWQKISDVIEDsVVEDyNsVDKTTTVSVSQQP
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86TG7 S10 Sugiyama PEG10 EDR KIAA1051e MAR2 MART2 MEF3L1 RGAG3 ___________MTERRRDELsEEINNLREKVMKQSEENNNL
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NEM2 S42 Sugiyama SHCBP1 GWAVEQELASLEKGLFQDEDsCsDCsYRDKPGssLQSFMPE
Q8NHW5 S304 Sugiyama RPLP0P6 DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WU90 S231 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 LPPGFVLKKDKKKEEKEDEIsLEDLIERERSALGPNVTKIT
Q8WUM4 T464 Sugiyama PDCD6IP AIP1 ALIX KIAA1375 LQRNREILDEsLRLLDEEEAtDNDLRAKFKERWQRtPSNEL
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q92882 S213 Sugiyama OSTF1 QGTDAVRtLsNAEDyLDDEDsD___________________
Q96C86 S72 Sugiyama DCPS DCS1 HINT5 HSPC015 VLRESARDKIIFLHGKVNEAsGDGDGEDAVVILEKTPFQVE
Q96D46 T470 Sugiyama NMD3 CGI-07 EAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAEMLEDLHIs
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 S145 Sugiyama ERO1A ERO1L UNQ434/PRO865 NNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNF
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96IR7 S365 Sugiyama HPDL GLOXD1 GATGFGQGNIRALWQsVQEQsARSQEA______________
Q96QK1 S760 Sugiyama VPS35 MEM3 TCCCTA00141 IQVLNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLR
Q96QK1 T763 Sugiyama VPS35 MEM3 TCCCTA00141 LNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLRREs
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99733 S53 Sugiyama NAP1L4 NAP2 QNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQL
Q99733 Y55 Sugiyama NAP1L4 NAP2 PRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQLQV
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 Y449 Sugiyama TUBA1C TUBA6 EKDyEEVGADsADGEDEGEEy____________________
Q9BS26 T154 Sugiyama ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 DyIRQQKSDPIQEIRDLAEIttLDRSKRNIIGYFEQKDSDN
Q9BXJ9 S855 Sugiyama NAA15 GA19 NARG1 NATH TBDN100 ALAFMPPGYEEDMKItVNGDssAEAEELANEI_________
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7 Y362 Sugiyama POTEKP ACTBL3 FKSG30 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9C0C2 S1173 Sugiyama TNKS1BP1 KIAA1741 TAB182 KttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMG
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H6T3 S503 Sugiyama RPAP3 DDLFPTsDtPRAKVLKIEEVsDTssLQPQAsLKQDVCQsYs
Q9HCC0 S256 Sugiyama MCCC2 MCCB QGTIFLAGPPLVKAATGEEVsAEDLGGADLHCRKSGVSDHW
Q9HCN8 S75 Sugiyama SDF2L1 UNQ1941/PRO4424 SHDIKYGSGSGQQSVtGVEAsDDANSyWRIRGGSEGGCPRG
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NWX6 S298 Sugiyama THG1L ICF45 HCDIIGDAFWKEHPEILDEDs____________________
Q9NZ53 S596 Sugiyama PODXL2 UNQ1861/PRO3742 ALNGPGsWGALMGGKRDPEDsDVFEEDtHL___________
Q9UHI6 S677 Sugiyama DDX20 DP103 GEMIN3 DSySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLE
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UI30 T123 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 SGRMFPISRGIPNMLLsEEEtEs__________________
Q9UNZ2 S165 Sugiyama NSFL1C UBXN2C SKPRPFAGGGYRLGAAPEEEsAyVAGEKRQHssQDVHVVLK
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9Y265 S434 Sugiyama RUVBL1 INO80H NMP238 TIP49 TIP49A NLLAKINGKDSIEKEHVEEIsELFyDAKSSAKILADQQDKY
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3B8 S201 Sugiyama REXO2 SFN SMFN CGI-114 PEEYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDE
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y3F4 S312 Sugiyama STRAP MAWD UNRIP WQTVVGKtyGLWKCVLPEEDsGELAKPKIGFPETTEEELEE
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 0.000001 5.945 0 0
Chromatin organization R-HSA-4839726 0.000001 5.829 0 0
Cell Cycle R-HSA-1640170 0.000003 5.600 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.000004 5.425 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.000005 5.295 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.000031 4.515 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.000062 4.208 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000074 4.133 0 0
Cell Cycle Checkpoints R-HSA-69620 0.000100 3.998 0 0
Apoptotic execution phase R-HSA-75153 0.000171 3.766 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000223 3.653 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000376 3.425 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000390 3.409 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000456 3.341 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 0.000558 3.253 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.000563 3.249 0 0
Regulation of TP53 Activity R-HSA-5633007 0.000626 3.203 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.000914 3.039 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.000990 3.004 0 0
Signaling by Hippo R-HSA-2028269 0.001207 2.918 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.001291 2.889 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.001405 2.852 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.001438 2.842 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.001509 2.821 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.001550 2.810 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.001590 2.798 0 0
M Phase R-HSA-68886 0.001699 2.770 0 0
G2/M Checkpoints R-HSA-69481 0.001698 2.770 0 0
Metabolism of RNA R-HSA-8953854 0.002076 2.683 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.002160 2.666 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.002217 2.654 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.002340 2.631 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.002521 2.598 0 0
Cellular response to heat stress R-HSA-3371556 0.002521 2.598 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.002889 2.539 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.003351 2.475 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.003806 2.419 0 0
Gene expression (Transcription) R-HSA-74160 0.003711 2.431 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.004012 2.397 0 0
DNA Repair R-HSA-73894 0.003940 2.405 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.005108 2.292 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.005108 2.292 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.004994 2.302 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.005110 2.292 0 0
Syndecan interactions R-HSA-3000170 0.004672 2.331 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.004994 2.302 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.005095 2.293 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.005194 2.284 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.005706 2.244 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.006230 2.205 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.006490 2.188 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.007353 2.134 0 0
Myogenesis R-HSA-525793 0.007409 2.130 0 0
Ephrin signaling R-HSA-3928664 0.007800 2.108 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.007696 2.114 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.008197 2.086 0 0
Signaling by VEGF R-HSA-194138 0.008187 2.087 0 0
G1/S-Specific Transcription R-HSA-69205 0.008297 2.081 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.008950 2.048 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.008950 2.048 0 0
NF-kB is activated and signals survival R-HSA-209560 0.008488 2.071 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.009252 2.034 0 0
mRNA Splicing R-HSA-72172 0.008723 2.059 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.010552 1.977 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.010881 1.963 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.010881 1.963 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.010881 1.963 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.010881 1.963 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.010450 1.981 0 0
Mitotic Prometaphase R-HSA-68877 0.009680 2.014 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.010355 1.985 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.010710 1.970 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.011552 1.937 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.012070 1.918 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.012070 1.918 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.012646 1.898 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.012944 1.888 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.012981 1.887 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.014280 1.845 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.014280 1.845 0 0
mRNA 3'-end processing R-HSA-72187 0.015062 1.822 0 0
Mitotic Anaphase R-HSA-68882 0.014783 1.830 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.014400 1.842 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.015409 1.812 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.015590 1.807 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.015816 1.801 0 0
G0 and Early G1 R-HSA-1538133 0.016055 1.794 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.016195 1.791 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.016278 1.788 0 0
Separation of Sister Chromatids R-HSA-2467813 0.017584 1.755 0 0
MTOR signalling R-HSA-165159 0.017564 1.755 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.017977 1.745 0 0
p75NTR signals via NF-kB R-HSA-193639 0.018591 1.731 0 0
p38MAPK events R-HSA-171007 0.018591 1.731 0 0
EPH-Ephrin signaling R-HSA-2682334 0.020605 1.686 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.020759 1.683 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.020752 1.683 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.020052 1.698 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.021156 1.675 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.021973 1.658 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.022035 1.657 0 0
Nuclear import of Rev protein R-HSA-180746 0.022283 1.652 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.023181 1.635 0 0
Homology Directed Repair R-HSA-5693538 0.024195 1.616 0 0
Signalling to ERKs R-HSA-187687 0.024675 1.608 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.024675 1.608 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.023643 1.626 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.024834 1.605 0 0
HDMs demethylate histones R-HSA-3214842 0.024834 1.605 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.025300 1.597 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.025939 1.586 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.025939 1.586 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.028804 1.541 0 0
Metabolism of non-coding RNA R-HSA-194441 0.026746 1.573 0 0
snRNP Assembly R-HSA-191859 0.026746 1.573 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.026921 1.570 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.026746 1.573 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.027166 1.566 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.028804 1.541 0 0
Mitotic Prophase R-HSA-68875 0.026844 1.571 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.029630 1.528 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.029961 1.523 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.030448 1.516 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.030998 1.509 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.030998 1.509 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.031246 1.505 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.031246 1.505 0 0
HIV elongation arrest and recovery R-HSA-167287 0.034807 1.458 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.034807 1.458 0 0
Heme signaling R-HSA-9707616 0.033288 1.478 0 0
Glycolysis R-HSA-70171 0.034771 1.459 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.031756 1.498 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.035939 1.444 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.036549 1.437 0 0
PECAM1 interactions R-HSA-210990 0.038196 1.418 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.038207 1.418 0 0
Interferon Signaling R-HSA-913531 0.038358 1.416 0 0
Regulation of signaling by CBL R-HSA-912631 0.038747 1.412 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.038747 1.412 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.039195 1.407 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.040092 1.397 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.040092 1.397 0 0
Translation initiation complex formation R-HSA-72649 0.047119 1.327 0 0
DNA Double Strand Break Response R-HSA-5693606 0.046462 1.333 0 0
HIV Life Cycle R-HSA-162587 0.045997 1.337 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.043592 1.361 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.042632 1.370 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.046253 1.335 0 0
Signalling to RAS R-HSA-167044 0.049295 1.307 0 0
HDACs deacetylate histones R-HSA-3214815 0.050489 1.297 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.051005 1.292 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.052181 1.282 0 0
Signaling by ALK in cancer R-HSA-9700206 0.052181 1.282 0 0
RNA Polymerase II Transcription R-HSA-73857 0.052553 1.279 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.052755 1.278 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.052755 1.278 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.055103 1.259 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.055103 1.259 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.054008 1.268 0 0
mTORC1-mediated signalling R-HSA-166208 0.061263 1.213 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.061300 1.213 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.056268 1.250 0 0
Signaling by EGFR R-HSA-177929 0.054008 1.268 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.055103 1.259 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.059164 1.228 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.060694 1.217 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.055103 1.259 0 0
Apoptosis R-HSA-109581 0.055794 1.253 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.061494 1.211 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.099412 1.003 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.099412 1.003 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 0.099412 1.003 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.099412 1.003 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.099412 1.003 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.099412 1.003 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 0.145352 0.838 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 0.145352 0.838 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 0.145352 0.838 0 0
IKBKB deficiency causes SCID R-HSA-5602636 0.145352 0.838 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 0.145352 0.838 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.188952 0.724 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 0.188952 0.724 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.188952 0.724 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.188952 0.724 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.188952 0.724 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.188952 0.724 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.188952 0.724 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.097368 1.012 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.097368 1.012 0 0
Recycling of eIF2:GDP R-HSA-72731 0.097368 1.012 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 0.230330 0.638 0 0
PLC-gamma1 signalling R-HSA-167021 0.230330 0.638 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.230330 0.638 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 0.230330 0.638 0 0
Invadopodia formation R-HSA-8941237 0.230330 0.638 0 0
Type I hemidesmosome assembly R-HSA-446107 0.113970 0.943 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.113970 0.943 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.131227 0.882 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 0.269599 0.569 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.269599 0.569 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.269599 0.569 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.149031 0.827 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.089034 1.050 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 0.306867 0.513 0 0
IRS activation R-HSA-74713 0.306867 0.513 0 0
G2 Phase R-HSA-68911 0.306867 0.513 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 0.306867 0.513 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.074623 1.127 0 0
Deadenylation of mRNA R-HSA-429947 0.074623 1.127 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.185883 0.731 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.185883 0.731 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.185883 0.731 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.185883 0.731 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.204756 0.689 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.204756 0.689 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.204756 0.689 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.204756 0.689 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.204756 0.689 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.342235 0.466 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.342235 0.466 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 0.342235 0.466 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.342235 0.466 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.342235 0.466 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.097157 1.013 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.144786 0.839 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.144786 0.839 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.105299 0.978 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.105299 0.978 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.105299 0.978 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.113740 0.944 0 0
Activation of the pre-replicative complex R-HSA-68962 0.122468 0.912 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.169645 0.770 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.375801 0.425 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.375801 0.425 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.375801 0.425 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 0.375801 0.425 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 0.375801 0.425 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.375801 0.425 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.071903 1.143 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.182506 0.739 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.103311 0.986 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.262275 0.581 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.262275 0.581 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.262275 0.581 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.262275 0.581 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.262275 0.581 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.195617 0.709 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.195617 0.709 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.098416 1.007 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.160016 0.796 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.208948 0.680 0 0
Phosphorylation of the APC/C R-HSA-176412 0.281540 0.550 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.407656 0.390 0 0
SOS-mediated signalling R-HSA-112412 0.407656 0.390 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 0.407656 0.390 0 0
Disinhibition of SNARE formation R-HSA-114516 0.407656 0.390 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.407656 0.390 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.104265 0.982 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.104265 0.982 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.300760 0.522 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.300760 0.522 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 0.300760 0.522 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 0.300760 0.522 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.190581 0.720 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.156231 0.806 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.249997 0.602 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 0.319892 0.495 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.437887 0.359 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.437887 0.359 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.437887 0.359 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.437887 0.359 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.437887 0.359 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.263945 0.578 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.338893 0.470 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.338893 0.470 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.136677 0.864 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.277985 0.556 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.149110 0.826 0 0
Centrosome maturation R-HSA-380287 0.149110 0.826 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.357727 0.446 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.357727 0.446 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.123233 0.909 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.376363 0.424 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.376363 0.424 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.149496 0.825 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.394771 0.404 0 0
Dual incision in TC-NER R-HSA-6782135 0.265901 0.575 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.182487 0.739 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.313994 0.503 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.313994 0.503 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.313994 0.503 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.285721 0.544 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.362924 0.440 0 0
Recycling pathway of L1 R-HSA-437239 0.325697 0.487 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.248894 0.604 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.430805 0.366 0 0
FGFR2 alternative splicing R-HSA-6803529 0.430805 0.366 0 0
Notch-HLH transcription pathway R-HSA-350054 0.430805 0.366 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.315921 0.500 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.315921 0.500 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.297207 0.527 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.346494 0.460 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.384389 0.415 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.384389 0.415 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.396088 0.402 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.396088 0.402 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.377231 0.423 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.290524 0.537 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.419367 0.377 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.430929 0.366 0 0
Transcription of the HIV genome R-HSA-167172 0.366979 0.435 0 0
EGFR downregulation R-HSA-182971 0.306249 0.514 0 0
Nucleotide Excision Repair R-HSA-5696398 0.092031 1.036 0 0
HIV Transcription Elongation R-HSA-167169 0.103311 0.986 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.334614 0.475 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.223824 0.650 0 0
RAF activation R-HSA-5673000 0.362924 0.440 0 0
mRNA Capping R-HSA-72086 0.277985 0.556 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.149496 0.825 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.199562 0.700 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.210994 0.676 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.275347 0.560 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.080046 1.097 0 0
DNA Damage Bypass R-HSA-73893 0.349172 0.457 0 0
RNA Polymerase III Transcription R-HSA-74158 0.190581 0.720 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.103311 0.986 0 0
Integrin signaling R-HSA-354192 0.150259 0.823 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.169645 0.770 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.117394 0.930 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.156231 0.806 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.156231 0.806 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.292094 0.534 0 0
Frs2-mediated activation R-HSA-170968 0.223824 0.650 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.123365 0.909 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.150259 0.823 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.397717 0.400 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.397717 0.400 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.430805 0.366 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.148075 0.830 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.069899 1.156 0 0
PI3K/AKT activation R-HSA-198203 0.149031 0.827 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.081810 1.087 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.081810 1.087 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.096603 1.015 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.262275 0.581 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.281540 0.550 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.320429 0.494 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.169997 0.770 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.201155 0.696 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.387479 0.412 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.066580 1.177 0 0
Signaling by RAS mutants R-HSA-6802949 0.156231 0.806 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.122468 0.912 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.290714 0.537 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.412926 0.384 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.261831 0.582 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.380096 0.420 0 0
Signaling by FGFR2 R-HSA-5654738 0.182370 0.739 0 0
Signaling by FGFR4 R-HSA-5654743 0.132332 0.878 0 0
Regulation of gap junction activity R-HSA-191650 0.269599 0.569 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.079213 1.101 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.169645 0.770 0 0
Trafficking of AMPA receptors R-HSA-399719 0.131472 0.881 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.300760 0.522 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.338893 0.470 0 0
Translesion Synthesis by POLH R-HSA-110320 0.357727 0.446 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.182370 0.739 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.277985 0.556 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.292094 0.534 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.377013 0.424 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.227671 0.643 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.202544 0.693 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.357727 0.446 0 0
Signaling by FGFR3 R-HSA-5654741 0.148075 0.830 0 0
Long-term potentiation R-HSA-9620244 0.081810 1.087 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.249997 0.602 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.236077 0.627 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.377013 0.424 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.325697 0.487 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.418135 0.379 0 0
Prolonged ERK activation events R-HSA-169893 0.281540 0.550 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.139884 0.854 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.069899 1.156 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.306867 0.513 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.121271 0.916 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.204756 0.689 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.150259 0.823 0 0
PTK6 Expression R-HSA-8849473 0.407656 0.390 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.222472 0.653 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.300760 0.522 0 0
MET promotes cell motility R-HSA-8875878 0.211899 0.674 0 0
DARPP-32 events R-HSA-180024 0.277985 0.556 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.267686 0.572 0 0
Negative regulation of MET activity R-HSA-6807004 0.376363 0.424 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 0.376363 0.424 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.394771 0.404 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.217203 0.663 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.404978 0.393 0 0
Signaling by FGFR R-HSA-190236 0.346463 0.460 0 0
Signaling by FGFR1 R-HSA-5654736 0.246410 0.608 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.121271 0.916 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.244576 0.612 0 0
HSF1-dependent transactivation R-HSA-3371571 0.372664 0.429 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.202544 0.693 0 0
Integrin cell surface interactions R-HSA-216083 0.297207 0.527 0 0
G2/M Transition R-HSA-69275 0.193226 0.714 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.236164 0.627 0 0
L1CAM interactions R-HSA-373760 0.149496 0.825 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.097368 1.012 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.167280 0.777 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.182506 0.739 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.062650 1.203 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.236164 0.627 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.412926 0.384 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.430805 0.366 0 0
S Phase R-HSA-69242 0.257195 0.590 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.292094 0.534 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.277985 0.556 0 0
DAP12 signaling R-HSA-2424491 0.292094 0.534 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.329769 0.482 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.236164 0.627 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.305803 0.515 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.404978 0.393 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.397717 0.400 0 0
Signaling by WNT in cancer R-HSA-4791275 0.320429 0.494 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.113746 0.944 0 0
Signal transduction by L1 R-HSA-445144 0.376363 0.424 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.117394 0.930 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.095075 1.022 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.203073 0.692 0 0
G1/S Transition R-HSA-69206 0.203570 0.691 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.121271 0.916 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.066261 1.179 0 0
Chromosome Maintenance R-HSA-73886 0.279208 0.554 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.265488 0.576 0 0
Signaling by FGFR in disease R-HSA-1226099 0.142828 0.845 0 0
Manipulation of host energy metabolism R-HSA-9636667 0.145352 0.838 0 0
MET interacts with TNS proteins R-HSA-8875513 0.230330 0.638 0 0
Unwinding of DNA R-HSA-176974 0.131227 0.882 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.269599 0.569 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.306867 0.513 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.185883 0.731 0 0
Phosphorylation of Emi1 R-HSA-176417 0.342235 0.466 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.066580 1.177 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.223824 0.650 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.223824 0.650 0 0
CREB phosphorylation R-HSA-199920 0.375801 0.425 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.262275 0.581 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 0.407656 0.390 0 0
Mitochondrial ABC transporters R-HSA-1369007 0.407656 0.390 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.156231 0.806 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.319892 0.495 0 0
Co-stimulation by ICOS R-HSA-9927354 0.437887 0.359 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.233841 0.631 0 0
Diseases of Immune System R-HSA-5260271 0.233841 0.631 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.171923 0.765 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.357727 0.446 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.348785 0.457 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.275774 0.559 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.265488 0.576 0 0
Orc1 removal from chromatin R-HSA-68949 0.384389 0.415 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.286142 0.543 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.157638 0.802 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.286142 0.543 0 0
Synthesis of DNA R-HSA-69239 0.287796 0.541 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.249997 0.602 0 0
Neurexins and neuroligins R-HSA-6794361 0.208683 0.681 0 0
HATs acetylate histones R-HSA-3214847 0.222940 0.652 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.245012 0.611 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.156231 0.806 0 0
Membrane Trafficking R-HSA-199991 0.101025 0.996 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.371633 0.430 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.325697 0.487 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.310421 0.508 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.131227 0.882 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.204756 0.689 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.372143 0.429 0 0
Axon guidance R-HSA-422475 0.137067 0.863 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.310421 0.508 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.272953 0.564 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.069899 1.156 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.348785 0.457 0 0
HIV Infection R-HSA-162906 0.157874 0.802 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.218399 0.661 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.262388 0.581 0 0
Nervous system development R-HSA-9675108 0.183760 0.736 0 0
Autophagy R-HSA-9612973 0.427025 0.370 0 0
ABC-family proteins mediated transport R-HSA-382556 0.229874 0.639 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.079213 1.101 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.089034 1.050 0 0
Muscarinic acetylcholine receptors R-HSA-390648 0.306867 0.513 0 0
Signaling by LTK R-HSA-9842663 0.204756 0.689 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.090124 1.045 0 0
DNA strand elongation R-HSA-69190 0.140740 0.852 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.150259 0.823 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.407656 0.390 0 0
Laminin interactions R-HSA-3000157 0.222472 0.653 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.249997 0.602 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.320429 0.494 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.295293 0.530 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.219200 0.659 0 0
TNF signaling R-HSA-75893 0.246410 0.608 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.104678 0.980 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.190582 0.720 0 0
Macroautophagy R-HSA-1632852 0.317106 0.499 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.089034 1.050 0 0
Regulation of KIT signaling R-HSA-1433559 0.243018 0.614 0 0
Smooth Muscle Contraction R-HSA-445355 0.217937 0.662 0 0
Downstream signal transduction R-HSA-186763 0.306249 0.514 0 0
Rab regulation of trafficking R-HSA-9007101 0.380038 0.420 0 0
Signaling by ERBB2 R-HSA-1227986 0.285721 0.544 0 0
TCR signaling R-HSA-202403 0.194441 0.711 0 0
Lagging Strand Synthesis R-HSA-69186 0.394771 0.404 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.366979 0.435 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.334614 0.475 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.084586 1.073 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.136677 0.864 0 0
Signaling by MET R-HSA-6806834 0.182370 0.739 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.157062 0.804 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.157062 0.804 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.062602 1.203 0 0
ECM proteoglycans R-HSA-3000178 0.397717 0.400 0 0
Signaling by KIT in disease R-HSA-9669938 0.430805 0.366 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.216085 0.665 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.097157 1.013 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.216085 0.665 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.216085 0.665 0 0
TGFBR3 PTM regulation R-HSA-9839383 0.113970 0.943 0 0
Sensory perception of sour taste R-HSA-9729555 0.269599 0.569 0 0
NADE modulates death signalling R-HSA-205025 0.269599 0.569 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.110092 0.958 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.110092 0.958 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.342235 0.466 0 0
Abacavir transmembrane transport R-HSA-2161517 0.375801 0.425 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.150259 0.823 0 0
VLDL clearance R-HSA-8964046 0.407656 0.390 0 0
Ca2+ activated K+ channels R-HSA-1296052 0.407656 0.390 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.236164 0.627 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.319892 0.495 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 0.437887 0.359 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 0.437887 0.359 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.338893 0.470 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.245012 0.611 0 0
Specification of the neural plate border R-HSA-9834899 0.357727 0.446 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.396970 0.401 0 0
Death Receptor Signaling R-HSA-73887 0.072985 1.137 0 0
Developmental Biology R-HSA-1266738 0.096287 1.016 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.067633 1.170 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.302836 0.519 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.169645 0.770 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.277985 0.556 0 0
Deubiquitination R-HSA-5688426 0.092005 1.036 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.071558 1.145 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.143435 0.843 0 0
Formation of definitive endoderm R-HSA-9823730 0.144786 0.839 0 0
Post NMDA receptor activation events R-HSA-438064 0.069191 1.160 0 0
Signal Transduction R-HSA-162582 0.148242 0.829 1 0
Signaling by NTRKs R-HSA-166520 0.166928 0.777 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.077521 1.111 0 0
Basigin interactions R-HSA-210991 0.157062 0.804 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.096603 1.015 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.319892 0.495 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.338102 0.471 0 0
Mismatch Repair R-HSA-5358508 0.338893 0.470 0 0
Ion transport by P-type ATPases R-HSA-936837 0.326081 0.487 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.333397 0.477 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.356633 0.448 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.081543 1.089 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.131227 0.882 0 0
Rap1 signalling R-HSA-392517 0.132846 0.877 0 0
ERK/MAPK targets R-HSA-198753 0.157062 0.804 0 0
Kinesins R-HSA-983189 0.069585 1.157 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.150259 0.823 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.180190 0.744 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.285721 0.544 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.207209 0.684 0 0
Ub-specific processing proteases R-HSA-5689880 0.308419 0.511 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.121271 0.916 0 0
GAB1 signalosome R-HSA-180292 0.338893 0.470 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.302329 0.520 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.302329 0.520 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.270576 0.568 0 0
FLT3 signaling in disease R-HSA-9682385 0.190581 0.720 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.282852 0.548 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.124759 0.904 0 0
Co-stimulation by CD28 R-HSA-389356 0.337427 0.472 0 0
Co-inhibition by PD-1 R-HSA-389948 0.362651 0.441 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.185107 0.733 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 0.269599 0.569 0 0
Bicarbonate transporters R-HSA-425381 0.167280 0.777 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 0.306867 0.513 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.342235 0.466 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.169645 0.770 0 0
Signaling by LTK in cancer R-HSA-9842640 0.375801 0.425 0 0
NADPH regeneration R-HSA-389542 0.375801 0.425 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.375801 0.425 0 0
Regulation of PTEN localization R-HSA-8948747 0.407656 0.390 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.407656 0.390 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.407656 0.390 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.437887 0.359 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.338893 0.470 0 0
Signaling by NOTCH4 R-HSA-9013694 0.428303 0.368 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.315921 0.500 0 0
Host Interactions of HIV factors R-HSA-162909 0.300145 0.523 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.067626 1.170 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.157062 0.804 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.306249 0.514 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.275774 0.559 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.150259 0.823 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.356731 0.448 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.225708 0.646 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.387479 0.412 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.222234 0.653 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.222360 0.653 0 0
Diseases of DNA repair R-HSA-9675135 0.156231 0.806 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.097368 1.012 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.131227 0.882 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.079213 1.101 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.306867 0.513 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.342235 0.466 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.342235 0.466 0 0
Nef and signal transduction R-HSA-164944 0.375801 0.425 0 0
Lipid particle organization R-HSA-8964572 0.375801 0.425 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.182506 0.739 0 0
CHL1 interactions R-HSA-447041 0.407656 0.390 0 0
PKR-mediated signaling R-HSA-9833482 0.182370 0.739 0 0
Semaphorin interactions R-HSA-373755 0.315921 0.500 0 0
Potential therapeutics for SARS R-HSA-9679191 0.176485 0.753 0 0
Signaling by ALK R-HSA-201556 0.222799 0.652 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.209311 0.679 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.407938 0.389 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.342572 0.465 0 0
Glucose metabolism R-HSA-70326 0.087887 1.056 0 0
Inositol phosphate metabolism R-HSA-1483249 0.325705 0.487 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 0.342235 0.466 0 0
Metalloprotease DUBs R-HSA-5689901 0.236164 0.627 0 0
Adrenoceptors R-HSA-390696 0.437887 0.359 0 0
Mitochondrial biogenesis R-HSA-1592230 0.087887 1.056 0 0
Signaling by NOTCH3 R-HSA-9012852 0.419367 0.377 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.279162 0.554 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 0.394771 0.404 0 0
Generic Transcription Pathway R-HSA-212436 0.201926 0.695 0 0
Gene Silencing by RNA R-HSA-211000 0.176636 0.753 0 0
Programmed Cell Death R-HSA-5357801 0.206980 0.684 0 0
Signaling by TGFB family members R-HSA-9006936 0.227957 0.642 1 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.079213 1.101 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.375801 0.425 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.169997 0.770 0 0
tRNA processing in the nucleus R-HSA-6784531 0.164466 0.784 0 0
Maturation of nucleoprotein R-HSA-9694631 0.357727 0.446 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.334614 0.475 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.326195 0.487 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.290714 0.537 0 0
Signaling by TGFBR3 R-HSA-9839373 0.313994 0.503 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 0.306867 0.513 0 0
RET signaling R-HSA-8853659 0.391036 0.408 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.222799 0.652 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.226633 0.645 0 0
Nephron development R-HSA-9831926 0.338893 0.470 0 0
Gluconeogenesis R-HSA-70263 0.337427 0.472 0 0
Interleukin-7 signaling R-HSA-1266695 0.222472 0.653 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.122468 0.912 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.384389 0.415 0 0
DAG and IP3 signaling R-HSA-1489509 0.302329 0.520 0 0
Specification of primordial germ cells R-HSA-9827857 0.319892 0.495 0 0
Activation of BH3-only proteins R-HSA-114452 0.292094 0.534 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.280349 0.552 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.190581 0.720 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.384389 0.415 0 0
SARS-CoV Infections R-HSA-9679506 0.089868 1.046 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.418826 0.378 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.324313 0.489 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.357727 0.446 0 0
Calmodulin induced events R-HSA-111933 0.391036 0.408 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.222799 0.652 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.113740 0.944 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.187244 0.728 0 0
CaM pathway R-HSA-111997 0.391036 0.408 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.204756 0.689 0 0
Regulation of beta-cell development R-HSA-186712 0.275774 0.559 0 0
DNA Damage Reversal R-HSA-73942 0.262275 0.581 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.169997 0.770 0 0
Interleukin-12 signaling R-HSA-9020591 0.279390 0.554 0 0
Interleukin-12 family signaling R-HSA-447115 0.388552 0.411 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.439073 0.357 0 0
Cellular response to chemical stress R-HSA-9711123 0.439860 0.357 0 0
Aggrephagy R-HSA-9646399 0.446182 0.350 0 0
Generation of second messenger molecules R-HSA-202433 0.446182 0.350 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.446182 0.350 0 0
Interferon gamma signaling R-HSA-877300 0.447791 0.349 0 0
rRNA processing R-HSA-72312 0.448255 0.348 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.448391 0.348 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.448391 0.348 0 0
HCMV Early Events R-HSA-9609690 0.451391 0.345 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.452720 0.344 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.453858 0.343 0 0
MAPK family signaling cascades R-HSA-5683057 0.458981 0.338 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.459668 0.338 0 0
Extension of Telomeres R-HSA-180786 0.465209 0.332 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.465666 0.332 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.465666 0.332 0 0
Neurodegenerative Diseases R-HSA-8863678 0.465666 0.332 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.465666 0.332 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.465666 0.332 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.465666 0.332 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.466577 0.331 0 0
WNT mediated activation of DVL R-HSA-201688 0.466577 0.331 0 0
ALK mutants bind TKIs R-HSA-9700645 0.466577 0.331 0 0
Calcineurin activates NFAT R-HSA-2025928 0.466577 0.331 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.466577 0.331 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.466577 0.331 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.466577 0.331 0 0
ARMS-mediated activation R-HSA-170984 0.466577 0.331 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.466577 0.331 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.466577 0.331 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.466577 0.331 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 0.466577 0.331 0 0
Lipophagy R-HSA-9613354 0.466577 0.331 0 0
Interleukin-1 processing R-HSA-448706 0.466577 0.331 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.466577 0.331 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.466577 0.331 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.466577 0.331 0 0
RNA Polymerase I Transcription R-HSA-73864 0.468558 0.329 0 0
MAP2K and MAPK activation R-HSA-5674135 0.473011 0.325 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.476475 0.322 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.476475 0.322 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.476475 0.322 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.476475 0.322 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.476475 0.322 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.476475 0.322 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.476475 0.322 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.482616 0.316 0 0
TGFBR3 expression R-HSA-9839394 0.482616 0.316 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.482616 0.316 0 0
Vesicle-mediated transport R-HSA-5653656 0.484380 0.315 0 0
Ca-dependent events R-HSA-111996 0.486201 0.313 0 0
MAP kinase activation R-HSA-450294 0.487649 0.312 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.488255 0.311 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.488734 0.311 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.488937 0.311 0 0
Cell-Cell communication R-HSA-1500931 0.493165 0.307 0 0
Cell junction organization R-HSA-446728 0.493745 0.306 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.493804 0.306 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.493804 0.306 0 0
Regulation of CDH11 function R-HSA-9762292 0.493804 0.306 0 0
Binding and entry of HIV virion R-HSA-173107 0.493804 0.306 0 0
2-LTR circle formation R-HSA-164843 0.493804 0.306 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.493804 0.306 0 0
Signal attenuation R-HSA-74749 0.493804 0.306 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.493804 0.306 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.493804 0.306 0 0
Pexophagy R-HSA-9664873 0.493804 0.306 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.493804 0.306 0 0
Signaling by Leptin R-HSA-2586552 0.493804 0.306 0 0
Signaling by ROBO receptors R-HSA-376176 0.495049 0.305 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.496212 0.304 0 0
Telomere Maintenance R-HSA-157579 0.497623 0.303 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.498724 0.302 0 0
Signaling by PDGF R-HSA-186797 0.498724 0.302 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.498724 0.302 0 0
MET activates PTK2 signaling R-HSA-8874081 0.499229 0.302 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.499229 0.302 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.499229 0.302 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.499229 0.302 0 0
Signaling by SCF-KIT R-HSA-1433557 0.499230 0.302 0 0
TBC/RABGAPs R-HSA-8854214 0.499230 0.302 0 0
SLC transporter disorders R-HSA-5619102 0.502582 0.299 0 0
Adipogenesis R-HSA-9843745 0.504254 0.297 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.505269 0.296 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.509695 0.293 0 0
Signaling by PTK6 R-HSA-8848021 0.509695 0.293 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.509695 0.293 0 0
Circadian clock R-HSA-9909396 0.511823 0.291 0 0
DAP12 interactions R-HSA-2172127 0.512089 0.291 0 0
RMTs methylate histone arginines R-HSA-3214858 0.512089 0.291 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.515496 0.288 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.515496 0.288 0 0
Cristae formation R-HSA-8949613 0.515496 0.288 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.515496 0.288 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.519643 0.284 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.519643 0.284 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.519643 0.284 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.519643 0.284 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.519643 0.284 0 0
Signaling by APC mutants R-HSA-4839744 0.519643 0.284 0 0
Synthesis of PI R-HSA-1483226 0.519643 0.284 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.519643 0.284 0 0
Suppression of apoptosis R-HSA-9635465 0.519643 0.284 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.519643 0.284 0 0
Prostanoid ligand receptors R-HSA-391908 0.519643 0.284 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.524771 0.280 0 0
Nucleosome assembly R-HSA-774815 0.524771 0.280 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.524771 0.280 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.524771 0.280 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.527119 0.278 0 0
Telomere Extension By Telomerase R-HSA-171319 0.531408 0.275 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.531408 0.275 0 0
Interleukin-1 signaling R-HSA-9020702 0.532608 0.274 0 0
Cilium Assembly R-HSA-5617833 0.533818 0.273 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.534043 0.272 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.536608 0.270 0 0
DS-GAG biosynthesis R-HSA-2022923 0.544165 0.264 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.544165 0.264 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 0.544165 0.264 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 0.544165 0.264 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.544165 0.264 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.544165 0.264 0 0
Signaling by AXIN mutants R-HSA-4839735 0.544165 0.264 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.544165 0.264 0 0
Activation of RAC1 R-HSA-428540 0.544165 0.264 0 0
Integration of provirus R-HSA-162592 0.544165 0.264 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.546008 0.263 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.546008 0.263 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.546960 0.262 0 0
Signaling by Erythropoietin R-HSA-9006335 0.546960 0.262 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.549054 0.260 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.551765 0.258 0 0
Kidney development R-HSA-9830369 0.552428 0.258 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.552533 0.258 0 0
Opioid Signalling R-HSA-111885 0.558162 0.253 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.560934 0.251 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.562147 0.250 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.562291 0.250 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.564531 0.248 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.566534 0.247 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.566534 0.247 0 0
Adaptive Immune System R-HSA-1280218 0.566940 0.246 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 0.567436 0.246 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 0.567436 0.246 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.567436 0.246 0 0
Leading Strand Synthesis R-HSA-69109 0.567436 0.246 0 0
Polymerase switching R-HSA-69091 0.567436 0.246 0 0
Repression of WNT target genes R-HSA-4641265 0.567436 0.246 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.567436 0.246 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.567436 0.246 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.567436 0.246 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.567436 0.246 0 0
Regulation of IFNG signaling R-HSA-877312 0.567436 0.246 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.567436 0.246 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.567436 0.246 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.567436 0.246 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.567436 0.246 0 0
Pervasive developmental disorders R-HSA-9005895 0.567436 0.246 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.567436 0.246 0 0
Disorders of Nervous System Development R-HSA-9697154 0.567436 0.246 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 0.567436 0.246 0 0
Gap junction trafficking and regulation R-HSA-157858 0.573604 0.241 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.573604 0.241 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.573604 0.241 0 0
Selective autophagy R-HSA-9663891 0.573647 0.241 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.575100 0.240 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.576965 0.239 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.576965 0.239 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.576965 0.239 0 0
Cargo concentration in the ER R-HSA-5694530 0.576965 0.239 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.576965 0.239 0 0
Interleukin-17 signaling R-HSA-448424 0.583143 0.234 0 0
PI3K Cascade R-HSA-109704 0.585313 0.233 0 0
ESR-mediated signaling R-HSA-8939211 0.587073 0.231 0 0
Influenza Infection R-HSA-168255 0.587887 0.231 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.589520 0.230 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.589520 0.230 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.589520 0.230 0 0
Formation of axial mesoderm R-HSA-9796292 0.589520 0.230 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.589520 0.230 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.589520 0.230 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.589520 0.230 0 0
Maturation of nucleoprotein R-HSA-9683610 0.589520 0.230 0 0
Interleukin-6 signaling R-HSA-1059683 0.589520 0.230 0 0
Adherens junctions interactions R-HSA-418990 0.591006 0.228 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.591413 0.228 0 0
Downstream TCR signaling R-HSA-202424 0.591574 0.228 0 0
Cellular Senescence R-HSA-2559583 0.594179 0.226 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.598905 0.223 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.598905 0.223 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.598905 0.223 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.605490 0.218 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.605490 0.218 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.606023 0.218 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.607195 0.217 0 0
Neutrophil degranulation R-HSA-6798695 0.610252 0.214 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 0.610478 0.214 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.610478 0.214 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.610478 0.214 0 0
cGMP effects R-HSA-418457 0.610478 0.214 0 0
Signal regulatory protein family interactions R-HSA-391160 0.610478 0.214 0 0
Zinc transporters R-HSA-435354 0.610478 0.214 0 0
Protein folding R-HSA-391251 0.617665 0.209 0 0
Meiotic synapsis R-HSA-1221632 0.619187 0.208 0 0
Striated Muscle Contraction R-HSA-390522 0.619196 0.208 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.619196 0.208 0 0
Cellular responses to stimuli R-HSA-8953897 0.625783 0.204 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.630051 0.201 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.630051 0.201 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.630368 0.200 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 0.630368 0.200 0 0
DCC mediated attractive signaling R-HSA-418885 0.630368 0.200 0 0
Translesion synthesis by REV1 R-HSA-110312 0.630368 0.200 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.630368 0.200 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.630368 0.200 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.630368 0.200 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.630368 0.200 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.630368 0.200 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.630368 0.200 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.630368 0.200 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.630368 0.200 0 0
Protein methylation R-HSA-8876725 0.630368 0.200 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.630368 0.200 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.632532 0.199 0 0
Dual Incision in GG-NER R-HSA-5696400 0.632532 0.199 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 0.632532 0.199 0 0
Gap junction assembly R-HSA-190861 0.632532 0.199 0 0
Signaling by NOTCH2 R-HSA-1980145 0.632532 0.199 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.640744 0.193 0 0
Signaling by NOTCH1 R-HSA-1980143 0.640744 0.193 0 0
UCH proteinases R-HSA-5689603 0.640744 0.193 0 0
Regulation of Apoptosis R-HSA-169911 0.645500 0.190 0 0
Gastrulation R-HSA-9758941 0.646225 0.190 0 0
Translesion synthesis by POLI R-HSA-5656121 0.649243 0.188 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.649243 0.188 0 0
Killing mechanisms R-HSA-9664420 0.649243 0.188 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.649243 0.188 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.649243 0.188 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.649243 0.188 0 0
Negative regulation of FLT3 R-HSA-9706369 0.649243 0.188 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.649243 0.188 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.649243 0.188 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.649243 0.188 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.649243 0.188 0 0
Atorvastatin ADME R-HSA-9754706 0.649243 0.188 0 0
NRAGE signals death through JNK R-HSA-193648 0.651130 0.186 0 0
Ion homeostasis R-HSA-5578775 0.651130 0.186 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.651130 0.186 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.651130 0.186 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.651130 0.186 0 0
Hemostasis R-HSA-109582 0.654595 0.184 0 0
Translation R-HSA-72766 0.656424 0.183 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.658103 0.182 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.658103 0.182 0 0
HSF1 activation R-HSA-3371511 0.658103 0.182 0 0
GPVI-mediated activation cascade R-HSA-114604 0.658103 0.182 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.658103 0.182 0 0
PCP/CE pathway R-HSA-4086400 0.658744 0.181 0 0
ABC transporter disorders R-HSA-5619084 0.658744 0.181 0 0
Toll-like Receptor Cascades R-HSA-168898 0.660218 0.180 0 0
IRS-mediated signalling R-HSA-112399 0.661343 0.180 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.661343 0.180 0 0
Cell-cell junction organization R-HSA-421270 0.661473 0.179 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.662695 0.179 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.665420 0.177 0 0
Translesion synthesis by POLK R-HSA-5655862 0.667155 0.176 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.667155 0.176 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.667155 0.176 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.667155 0.176 0 0
Fibronectin matrix formation R-HSA-1566977 0.667155 0.176 0 0
Synthesis of PG R-HSA-1483148 0.667155 0.176 0 0
Disorders of Developmental Biology R-HSA-9675151 0.667155 0.176 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.667155 0.176 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.667512 0.176 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.669412 0.174 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.670344 0.174 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.670344 0.174 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.670344 0.174 0 0
Degradation of DVL R-HSA-4641258 0.670344 0.174 0 0
Degradation of AXIN R-HSA-4641257 0.670344 0.174 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.670344 0.174 0 0
DNA Replication R-HSA-69306 0.671678 0.173 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.674298 0.171 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.674298 0.171 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.676125 0.170 0 0
Viral Infection Pathways R-HSA-9824446 0.679681 0.168 0 0
Elastic fibre formation R-HSA-1566948 0.682229 0.166 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 0.684153 0.165 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.684153 0.165 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.684153 0.165 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.684153 0.165 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.684153 0.165 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.684153 0.165 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.688115 0.162 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.688969 0.162 0 0
Signaling by WNT R-HSA-195721 0.692356 0.160 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.693760 0.159 0 0
Stabilization of p53 R-HSA-69541 0.693760 0.159 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.697133 0.157 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.700014 0.155 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.700014 0.155 0 0
PLC beta mediated events R-HSA-112043 0.700014 0.155 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.700285 0.155 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.700285 0.155 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.700285 0.155 0 0
Polo-like kinase mediated events R-HSA-156711 0.700285 0.155 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 0.700285 0.155 0 0
Platelet sensitization by LDL R-HSA-432142 0.700285 0.155 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.700285 0.155 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.700285 0.155 0 0
Tie2 Signaling R-HSA-210993 0.700285 0.155 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.700285 0.155 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.704417 0.152 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.704943 0.152 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.704943 0.152 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.704943 0.152 0 0
Attenuation phase R-HSA-3371568 0.704943 0.152 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.704943 0.152 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.704943 0.152 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.704943 0.152 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.704943 0.152 0 0
PTEN Regulation R-HSA-6807070 0.707791 0.150 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.709140 0.149 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.709140 0.149 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.709140 0.149 0 0
Pyrimidine biosynthesis R-HSA-500753 0.715593 0.145 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.715593 0.145 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 0.715593 0.145 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.715593 0.145 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 0.715593 0.145 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.715593 0.145 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 0.715593 0.145 0 0
Other interleukin signaling R-HSA-449836 0.715593 0.145 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.715593 0.145 0 0
The NLRP3 inflammasome R-HSA-844456 0.715593 0.145 0 0
Neddylation R-HSA-8951664 0.715778 0.145 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.715784 0.145 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.715784 0.145 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.715784 0.145 0 0
FLT3 Signaling R-HSA-9607240 0.715784 0.145 0 0
Meiosis R-HSA-1500620 0.716841 0.145 0 0
MHC class II antigen presentation R-HSA-2132295 0.721846 0.142 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.724749 0.140 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.726288 0.139 0 0
HIV Transcription Initiation R-HSA-167161 0.726288 0.139 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.726288 0.139 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.726288 0.139 0 0
Intra-Golgi traffic R-HSA-6811438 0.726288 0.139 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.726288 0.139 0 0
Neuronal System R-HSA-112316 0.726616 0.139 0 0
Insulin receptor signalling cascade R-HSA-74751 0.726748 0.139 0 0
IGF1R signaling cascade R-HSA-2428924 0.726748 0.139 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 0.730120 0.137 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.730120 0.137 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.730120 0.137 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.730120 0.137 0 0
Creatine metabolism R-HSA-71288 0.730120 0.137 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.730120 0.137 0 0
Nephrin family interactions R-HSA-373753 0.730120 0.137 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 0.730120 0.137 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.735233 0.134 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.743907 0.128 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 0.743907 0.128 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.743907 0.128 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.743907 0.128 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.743907 0.128 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.743907 0.128 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.746311 0.127 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.746311 0.127 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.746311 0.127 0 0
Cellular responses to stress R-HSA-2262752 0.750168 0.125 0 0
G-protein mediated events R-HSA-112040 0.751579 0.124 0 0
Platelet degranulation R-HSA-114608 0.752444 0.124 0 0
HCMV Infection R-HSA-9609646 0.753325 0.123 0 0
ER-Phagosome pathway R-HSA-1236974 0.753662 0.123 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.755843 0.122 0 0
Netrin-1 signaling R-HSA-373752 0.755843 0.122 0 0
Gap junction trafficking R-HSA-190828 0.755843 0.122 0 0
Amine ligand-binding receptors R-HSA-375280 0.755843 0.122 0 0
CS-GAG biosynthesis R-HSA-2022870 0.756989 0.121 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.756989 0.121 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.756989 0.121 0 0
Attachment and Entry R-HSA-9694614 0.756989 0.121 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.756989 0.121 0 0
Serine metabolism R-HSA-977347 0.756989 0.121 0 0
Immune System R-HSA-168256 0.757013 0.121 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.759443 0.120 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.759443 0.120 0 0
Base Excision Repair R-HSA-73884 0.760566 0.119 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.765063 0.116 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.765063 0.116 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.765063 0.116 0 0
Somitogenesis R-HSA-9824272 0.765063 0.116 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.765063 0.116 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.767318 0.115 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.769404 0.114 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.769404 0.114 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.769404 0.114 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.769404 0.114 0 0
LDL clearance R-HSA-8964038 0.769404 0.114 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.769404 0.114 0 0
Muscle contraction R-HSA-397014 0.771994 0.112 0 0
Signaling by Interleukins R-HSA-449147 0.772353 0.112 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.773980 0.111 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.774565 0.111 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.774565 0.111 0 0
Reproduction R-HSA-1474165 0.775104 0.111 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.776530 0.110 0 0
Signaling by Insulin receptor R-HSA-74752 0.780376 0.108 0 0
Formation of the ureteric bud R-HSA-9830674 0.781186 0.107 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.781186 0.107 0 0
Carnitine shuttle R-HSA-200425 0.781186 0.107 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.781186 0.107 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.781186 0.107 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.781186 0.107 0 0
Growth hormone receptor signaling R-HSA-982772 0.781186 0.107 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.782600 0.106 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.782600 0.106 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.784946 0.105 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.786683 0.104 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.787399 0.104 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.788900 0.103 0 0
Intraflagellar transport R-HSA-5620924 0.790930 0.102 0 0
NGF-stimulated transcription R-HSA-9031628 0.790930 0.102 0 0
Transmission across Chemical Synapses R-HSA-112315 0.791857 0.101 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.792366 0.101 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.792366 0.101 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.792366 0.101 0 0
Interleukin-6 family signaling R-HSA-6783589 0.792366 0.101 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.792846 0.101 0 0
Ca2+ pathway R-HSA-4086398 0.795779 0.099 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.798977 0.097 0 0
Degradation of CDH1 R-HSA-9766229 0.798977 0.097 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.798977 0.097 0 0
Signaling by ERBB4 R-HSA-1236394 0.802469 0.096 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.802976 0.095 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.802976 0.095 0 0
Tight junction interactions R-HSA-420029 0.802976 0.095 0 0
Formation of the nephric duct R-HSA-9830364 0.802976 0.095 0 0
Hyaluronan degradation R-HSA-2160916 0.802976 0.095 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.802976 0.095 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.802976 0.095 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.802976 0.095 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.806748 0.093 0 0
HCMV Late Events R-HSA-9610379 0.809011 0.092 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.810477 0.091 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.813044 0.090 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.813044 0.090 0 0
Sphingolipid catabolism R-HSA-9845614 0.813044 0.090 0 0
Abacavir ADME R-HSA-2161522 0.813044 0.090 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.813044 0.090 0 0
Meiotic recombination R-HSA-912446 0.814250 0.089 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.814250 0.089 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.815691 0.088 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.816545 0.088 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.819798 0.086 0 0
Ribosome-associated quality control R-HSA-9948299 0.820333 0.086 0 0
Translation of Structural Proteins R-HSA-9694635 0.821444 0.085 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.821491 0.085 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.822598 0.085 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.822598 0.085 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.822598 0.085 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.822598 0.085 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.822598 0.085 0 0
FOXO-mediated transcription R-HSA-9614085 0.826864 0.083 0 0
G alpha (12/13) signalling events R-HSA-416482 0.827415 0.082 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.827415 0.082 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.828478 0.082 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.828478 0.082 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.831665 0.080 0 0
Insulin receptor recycling R-HSA-77387 0.831665 0.080 0 0
Prednisone ADME R-HSA-9757110 0.831665 0.080 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.831665 0.080 0 0
Pyrimidine salvage R-HSA-73614 0.831665 0.080 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.831665 0.080 0 0
Inflammasomes R-HSA-622312 0.831665 0.080 0 0
Sensory processing of sound R-HSA-9659379 0.833213 0.079 0 0
Late endosomal microautophagy R-HSA-9615710 0.840269 0.076 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.840269 0.076 0 0
DNA methylation R-HSA-5334118 0.840269 0.076 0 0
Platelet calcium homeostasis R-HSA-418360 0.840269 0.076 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.840269 0.076 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.840269 0.076 0 0
G alpha (z) signalling events R-HSA-418597 0.841717 0.075 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.841717 0.075 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.848433 0.071 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.848433 0.071 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.848433 0.071 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.849613 0.071 0 0
Regulation of CDH1 Function R-HSA-9764561 0.854023 0.069 0 0
RSV-host interactions R-HSA-9833110 0.856117 0.067 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.856181 0.067 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.859750 0.066 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.859843 0.066 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.859843 0.066 0 0
HS-GAG degradation R-HSA-2024096 0.863533 0.064 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.863533 0.064 0 0
DAG1 glycosylations R-HSA-8931838 0.863533 0.064 0 0
tRNA processing R-HSA-72306 0.864556 0.063 0 0
Peroxisomal protein import R-HSA-9033241 0.865449 0.063 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.865449 0.063 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.865680 0.063 0 0
Nuclear RNA decay R-HSA-9930044 0.870509 0.060 0 0
G-protein beta:gamma signalling R-HSA-397795 0.870509 0.060 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.870509 0.060 0 0
Cardiogenesis R-HSA-9733709 0.870509 0.060 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.873193 0.059 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.873832 0.059 0 0
CS/DS degradation R-HSA-2024101 0.877130 0.057 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.877130 0.057 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.877130 0.057 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.877130 0.057 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.877752 0.057 0 0
Extracellular matrix organization R-HSA-1474244 0.878223 0.056 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.879384 0.056 0 0
Interleukin-1 family signaling R-HSA-446652 0.879384 0.056 0 0
Mitochondrial protein import R-HSA-1268020 0.881057 0.055 0 0
Diseases of programmed cell death R-HSA-9645723 0.882511 0.054 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.883412 0.054 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.883412 0.054 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.883412 0.054 0 0
Mitophagy R-HSA-5205647 0.883412 0.054 0 0
Signal amplification R-HSA-392518 0.883412 0.054 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.883412 0.054 0 0
Hyaluronan metabolism R-HSA-2142845 0.883412 0.054 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.883412 0.054 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.888492 0.051 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.888492 0.051 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.889373 0.051 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.889373 0.051 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.889373 0.051 0 0
PERK regulates gene expression R-HSA-381042 0.889373 0.051 0 0
Neurotransmitter release cycle R-HSA-112310 0.890654 0.050 0 0
Cellular response to hypoxia R-HSA-1234174 0.894976 0.048 0 0
HS-GAG biosynthesis R-HSA-2022928 0.895030 0.048 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.895030 0.048 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.895030 0.048 0 0
Glycosphingolipid transport R-HSA-9845576 0.895030 0.048 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.895030 0.048 0 0
RUNX2 regulates bone development R-HSA-8941326 0.895030 0.048 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.897647 0.047 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.897805 0.047 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.898288 0.047 0 0
IRE1alpha activates chaperones R-HSA-381070 0.898288 0.047 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.899829 0.046 0 0
Voltage gated Potassium channels R-HSA-1296072 0.900398 0.046 0 0
Metabolism of folate and pterines R-HSA-196757 0.900398 0.046 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.901923 0.045 0 0
Nicotinate metabolism R-HSA-196807 0.903398 0.044 0 0
Purine salvage R-HSA-74217 0.905492 0.043 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.910325 0.041 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.910325 0.041 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.910325 0.041 0 0
RAS processing R-HSA-9648002 0.910325 0.041 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.910325 0.041 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.910325 0.041 0 0
Parasite infection R-HSA-9664407 0.913295 0.039 0 0
Leishmania phagocytosis R-HSA-9664417 0.913295 0.039 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.913295 0.039 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.914912 0.039 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.914912 0.039 0 0
Interleukin-2 family signaling R-HSA-451927 0.914912 0.039 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.915315 0.038 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.915315 0.038 0 0
Eukaryotic Translation Termination R-HSA-72764 0.915315 0.038 0 0
Ion channel transport R-HSA-983712 0.918070 0.037 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.918381 0.037 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.919264 0.037 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.919264 0.037 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.919264 0.037 0 0
Maturation of spike protein R-HSA-9694548 0.919264 0.037 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.921770 0.035 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.923394 0.035 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.923394 0.035 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.923394 0.035 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.923394 0.035 0 0
Translation of Structural Proteins R-HSA-9683701 0.923394 0.035 0 0
Developmental Cell Lineages R-HSA-9734767 0.925717 0.034 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.927313 0.033 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.927313 0.033 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.927611 0.033 0 0
Hedgehog 'off' state R-HSA-5610787 0.929707 0.032 0 0
Formation of the cornified envelope R-HSA-6809371 0.930036 0.032 0 0
Defective pyroptosis R-HSA-9710421 0.931032 0.031 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.931158 0.031 0 0
Protein ubiquitination R-HSA-8852135 0.931158 0.031 0 0
Proteasome assembly R-HSA-9907900 0.934561 0.029 0 0
Methylation R-HSA-156581 0.934561 0.029 0 0
Cyclin D associated events in G1 R-HSA-69231 0.934561 0.029 0 0
G1 Phase R-HSA-69236 0.934561 0.029 0 0
Surfactant metabolism R-HSA-5683826 0.934561 0.029 0 0
PI Metabolism R-HSA-1483255 0.934807 0.029 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.936814 0.028 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.937226 0.028 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.937909 0.028 0 0
Interleukin-10 signaling R-HSA-6783783 0.939474 0.027 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.941086 0.026 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.941086 0.026 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.941086 0.026 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.941086 0.026 0 0
Protein localization R-HSA-9609507 0.944304 0.025 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.945053 0.025 0 0
Platelet homeostasis R-HSA-418346 0.946099 0.024 0 0
Metal ion SLC transporters R-HSA-425410 0.946961 0.024 0 0
PPARA activates gene expression R-HSA-1989781 0.947805 0.023 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.949676 0.022 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.951106 0.022 0 0
Azathioprine ADME R-HSA-9748787 0.952252 0.021 0 0
Complex IV assembly R-HSA-9864848 0.954696 0.020 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.954696 0.020 0 0
The phototransduction cascade R-HSA-2514856 0.954696 0.020 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.957015 0.019 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.957244 0.019 0 0
Nucleotide biosynthesis R-HSA-8956320 0.959215 0.018 0 0
Signaling by Hedgehog R-HSA-5358351 0.961433 0.017 0 0
Signaling by NOTCH R-HSA-157118 0.962044 0.017 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.962794 0.016 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.963284 0.016 0 0
Paracetamol ADME R-HSA-9753281 0.963284 0.016 0 0
Innate Immune System R-HSA-168249 0.964228 0.016 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.964362 0.016 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.965164 0.015 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.965384 0.015 0 0
Synthesis of PA R-HSA-1483166 0.966948 0.015 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.967155 0.015 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.969939 0.013 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.969987 0.013 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.970068 0.013 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.970246 0.013 0 0
Sialic acid metabolism R-HSA-4085001 0.970246 0.013 0 0
Post-translational protein modification R-HSA-597592 0.970850 0.013 0 0
tRNA Aminoacylation R-HSA-379724 0.971770 0.012 0 0
Metabolism of polyamines R-HSA-351202 0.971770 0.012 0 0
Mitochondrial protein degradation R-HSA-9837999 0.972496 0.012 0 0
Collagen formation R-HSA-1474290 0.972496 0.012 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.973216 0.012 0 0
Nucleotide salvage R-HSA-8956321 0.973216 0.012 0 0
Aquaporin-mediated transport R-HSA-445717 0.973216 0.012 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.973694 0.012 0 0
Parasitic Infection Pathways R-HSA-9824443 0.975899 0.011 0 0
Leishmania infection R-HSA-9658195 0.975899 0.011 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.975941 0.011 0 0
Mitochondrial translation elongation R-HSA-5389840 0.975941 0.011 0 0
Potassium Channels R-HSA-1296071 0.975941 0.011 0 0
Mitochondrial translation initiation R-HSA-5368286 0.978002 0.010 0 0
Regulation of insulin secretion R-HSA-422356 0.978002 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.979408 0.009 0 0
O-linked glycosylation of mucins R-HSA-913709 0.981464 0.008 0 0
Cardiac conduction R-HSA-5576891 0.982925 0.007 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.983210 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 0.983315 0.007 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.983315 0.007 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.984170 0.007 0 0
Retinoid metabolism and transport R-HSA-975634 0.984170 0.007 0 0
Hedgehog 'on' state R-HSA-5632684 0.984170 0.007 0 0
Metabolism of cofactors R-HSA-8978934 0.984170 0.007 0 0
Aspirin ADME R-HSA-9749641 0.985751 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.986482 0.006 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.986616 0.006 0 0
Integration of energy metabolism R-HSA-163685 0.986652 0.006 0 0
Iron uptake and transport R-HSA-917937 0.987175 0.006 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.987175 0.006 0 0
Mitochondrial translation termination R-HSA-5419276 0.987212 0.006 0 0
Mitochondrial translation R-HSA-5368287 0.987711 0.005 0 0
G alpha (i) signalling events R-HSA-418594 0.988505 0.005 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.989346 0.005 0 0
Sphingolipid metabolism R-HSA-428157 0.989751 0.004 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.990648 0.004 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.991132 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.991132 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.991582 0.004 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.992477 0.003 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.993275 0.003 0 0
Pyruvate metabolism R-HSA-70268 0.993531 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.993853 0.003 0 0
Peptide chain elongation R-HSA-156902 0.993863 0.003 0 0
Peptide ligand-binding receptors R-HSA-375276 0.994207 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.994476 0.002 0 0
Infectious disease R-HSA-5663205 0.994725 0.002 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.994760 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.994908 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.995284 0.002 0 0
FCGR activation R-HSA-2029481 0.995526 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.996327 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.996381 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.996906 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 0.997216 0.001 0 0
O-linked glycosylation R-HSA-5173105 0.997228 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.997448 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.997448 0.001 0 0
Viral mRNA Translation R-HSA-192823 0.997494 0.001 0 0
Keratinization R-HSA-6805567 0.997513 0.001 0 0
Metabolism of proteins R-HSA-392499 0.997787 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.998075 0.001 0 0
Stimuli-sensing channels R-HSA-2672351 0.998174 0.001 0 0
Visual phototransduction R-HSA-2187338 0.998351 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.998357 0.001 0 0
Diseases of glycosylation R-HSA-3781865 0.998422 0.001 0 0
Antimicrobial peptides R-HSA-6803157 0.998441 0.001 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.998940 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.998978 0.000 0 0
Cellular response to starvation R-HSA-9711097 0.999023 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.999040 0.000 0 0
Phospholipid metabolism R-HSA-1483257 0.999102 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 0.999267 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999285 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999321 0.000 0 0
Regulation of Complement cascade R-HSA-977606 0.999330 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999501 0.000 0 0
Sensory perception of taste R-HSA-9717189 0.999561 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.999561 0.000 0 0
Drug ADME R-HSA-9748784 0.999669 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999784 0.000 0 0
Transport of small molecules R-HSA-382551 0.999791 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 0.999791 0.000 0 0
Disease R-HSA-1643685 0.999798 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999808 0.000 0 0
Complement cascade R-HSA-166658 0.999812 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.999853 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999855 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 0.999900 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999926 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999948 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999969 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999987 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999991 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 0.999999 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 0.999999 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Signaling by NODAL R-HSA-1181150 1.000000 0.000 1 1
Regulation of signaling by NODAL R-HSA-1433617 1.000000 0.000 1 1
Signaling by Activin R-HSA-1502540 1.000000 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 9.992007e-16 15.000 0 0
Cellular responses to stress R-HSA-2262752 1.332268e-15 14.875 0 0
Cell Cycle R-HSA-1640170 5.551115e-15 14.256 0 0
HSF1-dependent transactivation R-HSA-3371571 2.320366e-14 13.634 0 0
Cell Cycle Checkpoints R-HSA-69620 1.182388e-13 12.927 0 0
Cellular responses to stimuli R-HSA-8953897 1.251221e-13 12.903 0 0
Attenuation phase R-HSA-3371568 4.767298e-13 12.322 0 0
Metabolism of RNA R-HSA-8953854 1.425748e-12 11.846 0 0
Cell Cycle, Mitotic R-HSA-69278 2.466360e-12 11.608 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.818257e-12 11.317 0 0
M Phase R-HSA-68886 6.743162e-12 11.171 0 0
HSF1 activation R-HSA-3371511 1.374156e-11 10.862 0 0
G2/M Checkpoints R-HSA-69481 4.359435e-11 10.361 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.457546e-11 10.263 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.457546e-11 10.263 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.256835e-10 9.901 0 0
Cellular Senescence R-HSA-2559583 1.958489e-10 9.708 0 0
Adherens junctions interactions R-HSA-418990 3.669879e-10 9.435 0 0
Cell-Cell communication R-HSA-1500931 6.893324e-10 9.162 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.094815e-09 8.961 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.374108e-09 8.862 0 0
Mitotic Anaphase R-HSA-68882 1.739002e-09 8.760 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.021729e-09 8.694 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.661266e-09 8.116 0 0
Cell-cell junction organization R-HSA-421270 7.346179e-09 8.134 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.000901e-09 8.046 0 0
Cell junction organization R-HSA-446728 8.795074e-09 8.056 0 0
DNA Double Strand Break Response R-HSA-5693606 1.477690e-08 7.830 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.522990e-08 7.817 0 0
Apoptotic execution phase R-HSA-75153 2.783369e-08 7.555 0 0
Separation of Sister Chromatids R-HSA-2467813 2.982255e-08 7.525 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.887649e-08 7.410 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.441500e-08 7.352 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.288985e-08 7.277 0 0
Chromatin organization R-HSA-4839726 6.781865e-08 7.169 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.960759e-08 7.048 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.060805e-07 6.974 0 0
Protein ubiquitination R-HSA-8852135 1.154454e-07 6.938 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.407270e-07 6.852 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.499044e-07 6.824 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.874612e-07 6.727 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.275823e-07 6.643 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.361270e-07 6.627 0 0
Chromatin modifying enzymes R-HSA-3247509 2.632839e-07 6.580 0 0
Ub-specific processing proteases R-HSA-5689880 3.341624e-07 6.476 0 0
Apoptosis R-HSA-109581 3.527742e-07 6.453 0 0
Regulation of CDH1 Function R-HSA-9764561 6.798410e-07 6.168 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.789537e-07 6.168 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.984401e-07 6.098 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.660557e-07 6.062 0 0
Homology Directed Repair R-HSA-5693538 9.224105e-07 6.035 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.075306e-06 5.968 0 0
Mitotic Prophase R-HSA-68875 1.283346e-06 5.892 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.492618e-06 5.826 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.509332e-06 5.821 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.747169e-06 5.758 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.403165e-06 5.619 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.526027e-06 5.598 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.480084e-06 5.606 0 0
Deubiquitination R-HSA-5688426 2.832987e-06 5.548 0 0
Meiotic synapsis R-HSA-1221632 3.087207e-06 5.510 0 0
Programmed Cell Death R-HSA-5357801 4.334281e-06 5.363 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.757725e-06 5.323 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.800378e-06 5.319 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.006325e-06 5.300 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.531396e-06 5.257 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.513745e-06 5.186 0 0
mRNA Splicing R-HSA-72172 8.235610e-06 5.084 0 0
Meiosis R-HSA-1500620 9.022093e-06 5.045 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.976757e-06 5.001 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.147135e-05 4.940 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.374385e-05 4.862 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.399153e-05 4.854 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.474872e-05 4.831 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.807583e-05 4.743 0 0
Nucleosome assembly R-HSA-774815 1.807583e-05 4.743 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.860904e-05 4.730 0 0
Mitotic Prometaphase R-HSA-68877 2.029264e-05 4.693 0 0
Gene expression (Transcription) R-HSA-74160 2.102057e-05 4.677 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.594920e-05 4.586 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.577155e-05 4.589 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.581599e-05 4.588 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.696320e-05 4.569 0 0
ESR-mediated signaling R-HSA-8939211 2.987983e-05 4.525 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.143127e-05 4.503 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.674596e-05 4.435 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.015159e-05 4.396 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.494785e-05 4.347 0 0
HDACs deacetylate histones R-HSA-3214815 5.207698e-05 4.283 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.383245e-05 4.269 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.575329e-05 4.254 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.511125e-05 4.186 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.247826e-05 4.140 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.183912e-05 4.087 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.800426e-05 4.108 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.560232e-05 4.068 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.263147e-05 4.033 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.318287e-05 4.031 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.830722e-05 4.007 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.205661e-04 3.919 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.327278e-04 3.877 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.327278e-04 3.877 0 0
rRNA processing R-HSA-72312 1.332656e-04 3.875 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.348249e-04 3.870 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.348249e-04 3.870 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.352775e-04 3.869 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.474730e-04 3.831 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.472268e-04 3.832 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.532390e-04 3.815 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.532390e-04 3.815 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.653779e-04 3.782 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.994804e-04 3.700 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.994804e-04 3.700 0 0
PKR-mediated signaling R-HSA-9833482 2.029484e-04 3.693 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.952752e-04 3.709 0 0
Signaling by ALK in cancer R-HSA-9700206 1.952752e-04 3.709 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.221988e-04 3.653 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.255154e-04 3.647 0 0
Meiotic recombination R-HSA-912446 2.128954e-04 3.672 0 0
S Phase R-HSA-69242 2.121266e-04 3.673 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.113434e-04 3.675 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.112841e-04 3.675 0 0
Nervous system development R-HSA-9675108 2.216857e-04 3.654 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.112841e-04 3.675 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.651641e-04 3.576 0 0
DNA Repair R-HSA-73894 2.766744e-04 3.558 0 0
Interleukin-12 signaling R-HSA-9020591 2.794785e-04 3.554 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.832332e-04 3.548 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.289730e-04 3.483 0 0
DNA Replication R-HSA-69306 3.575558e-04 3.447 0 0
Regulation of TP53 Activity R-HSA-5633007 3.602845e-04 3.443 0 0
RNA Polymerase I Transcription R-HSA-73864 3.782148e-04 3.422 0 0
Degradation of CDH1 R-HSA-9766229 4.254184e-04 3.371 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.363014e-04 3.360 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.014135e-04 3.300 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.240883e-04 3.281 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.280969e-04 3.277 0 0
Aggrephagy R-HSA-9646399 5.381551e-04 3.269 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.622799e-04 3.250 0 0
Co-inhibition by PD-1 R-HSA-389948 5.987053e-04 3.223 0 0
Oncogene Induced Senescence R-HSA-2559585 5.912836e-04 3.228 0 0
Axon guidance R-HSA-422475 6.042157e-04 3.219 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.252309e-04 3.204 0 0
Interleukin-12 family signaling R-HSA-447115 6.388024e-04 3.195 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.540313e-04 3.184 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.561430e-04 3.183 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.975133e-04 3.156 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.027089e-04 3.153 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.027089e-04 3.153 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.027089e-04 3.153 0 0
Signaling by RAS mutants R-HSA-6802949 7.027089e-04 3.153 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.193236e-04 3.143 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.372960e-04 3.132 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.646777e-04 3.117 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.869136e-04 3.052 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.869136e-04 3.052 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.869136e-04 3.052 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.869136e-04 3.052 0 0
Packaging Of Telomere Ends R-HSA-171306 8.442425e-04 3.074 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.442425e-04 3.074 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.984018e-04 3.047 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 9.210012e-04 3.036 0 0
Translation initiation complex formation R-HSA-72649 1.018894e-03 2.992 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.081483e-03 2.966 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.931097e-04 3.003 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.107733e-03 2.956 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.134593e-03 2.945 0 0
Membrane Trafficking R-HSA-199991 1.150427e-03 2.939 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.160379e-03 2.935 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.160379e-03 2.935 0 0
Defective pyroptosis R-HSA-9710421 1.161160e-03 2.935 0 0
Interferon Signaling R-HSA-913531 1.235118e-03 2.908 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.328262e-03 2.877 0 0
DNA methylation R-HSA-5334118 1.341656e-03 2.872 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.365342e-03 2.865 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.394102e-03 2.856 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.449011e-03 2.839 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.565175e-03 2.805 0 0
RNA Polymerase II Transcription R-HSA-73857 1.455673e-03 2.837 0 0
Signaling by NOTCH R-HSA-157118 1.462624e-03 2.835 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.576141e-03 2.802 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.502360e-03 2.823 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.590519e-03 2.798 0 0
HATs acetylate histones R-HSA-3214847 1.595883e-03 2.797 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.632036e-03 2.787 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.637355e-03 2.786 0 0
Selective autophagy R-HSA-9663891 1.655814e-03 2.781 0 0
Diseases of programmed cell death R-HSA-9645723 1.655814e-03 2.781 0 0
Activation of BH3-only proteins R-HSA-114452 1.668477e-03 2.778 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.822156e-03 2.739 0 0
Reproduction R-HSA-1474165 1.875386e-03 2.727 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.884243e-03 2.725 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.884243e-03 2.725 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.884243e-03 2.725 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.919431e-03 2.717 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.919431e-03 2.717 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.919431e-03 2.717 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.953275e-03 2.709 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.953275e-03 2.709 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.008500e-03 2.697 0 0
Signaling by VEGF R-HSA-194138 2.070874e-03 2.684 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.284501e-03 2.641 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.266077e-03 2.645 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.287082e-03 2.641 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.267281e-03 2.644 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.418067e-03 2.617 0 0
Smooth Muscle Contraction R-HSA-445355 2.267800e-03 2.644 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.517308e-03 2.599 0 0
Chromosome Maintenance R-HSA-73886 2.518400e-03 2.599 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.540299e-03 2.595 0 0
Signaling by ERBB2 R-HSA-1227986 2.540299e-03 2.595 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.635728e-03 2.579 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.659270e-03 2.575 0 0
Josephin domain DUBs R-HSA-5689877 2.659270e-03 2.575 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.659270e-03 2.575 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.707777e-03 2.567 0 0
MTOR signalling R-HSA-165159 2.710650e-03 2.567 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.733055e-03 2.563 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.754180e-03 2.560 0 0
Signal Transduction R-HSA-162582 2.763138e-03 2.559 1 0
Macroautophagy R-HSA-1632852 2.924675e-03 2.534 0 0
EPH-Ephrin signaling R-HSA-2682334 2.955598e-03 2.529 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.056699e-03 2.515 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.056699e-03 2.515 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.056699e-03 2.515 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.203731e-03 2.494 0 0
Autophagy R-HSA-9612973 3.306794e-03 2.481 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.348238e-03 2.475 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.348238e-03 2.475 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.175013e-03 2.379 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.175013e-03 2.379 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.175013e-03 2.379 0 0
Regulation of signaling by CBL R-HSA-912631 4.119963e-03 2.385 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.685275e-03 2.434 0 0
Striated Muscle Contraction R-HSA-390522 3.685275e-03 2.434 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.768616e-03 2.424 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.068411e-03 2.391 0 0
Translesion Synthesis by POLH R-HSA-110320 4.119963e-03 2.385 0 0
Stabilization of p53 R-HSA-69541 3.768616e-03 2.424 0 0
G2/M Transition R-HSA-69275 3.667563e-03 2.436 0 0
Semaphorin interactions R-HSA-373755 3.825386e-03 2.417 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.750362e-03 2.426 0 0
Influenza Infection R-HSA-168255 3.802939e-03 2.420 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.227689e-03 2.374 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.244868e-03 2.372 0 0
Regulation of PTEN localization R-HSA-8948747 4.255263e-03 2.371 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.379784e-03 2.359 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.449613e-03 2.352 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.449613e-03 2.352 0 0
PTEN Regulation R-HSA-6807070 4.580247e-03 2.339 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.885393e-03 2.311 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.885393e-03 2.311 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.185236e-03 2.285 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.225679e-03 2.282 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.282661e-03 2.277 0 0
NF-kB is activated and signals survival R-HSA-209560 5.282661e-03 2.277 0 0
snRNP Assembly R-HSA-191859 5.289732e-03 2.277 0 0
Metabolism of non-coding RNA R-HSA-194441 5.289732e-03 2.277 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.477342e-03 2.261 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.611814e-03 2.251 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.611814e-03 2.251 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.830896e-03 2.234 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.851465e-03 2.233 0 0
Recycling pathway of L1 R-HSA-437239 5.893375e-03 2.230 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.893375e-03 2.230 0 0
Formation of annular gap junctions R-HSA-196025 6.302140e-03 2.201 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.062319e-03 2.151 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.119556e-03 2.148 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.084848e-03 2.216 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.062319e-03 2.151 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.520126e-03 2.186 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.209133e-03 2.207 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.520126e-03 2.186 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.119612e-03 2.148 0 0
Host Interactions of HIV factors R-HSA-162909 6.344593e-03 2.198 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.150891e-03 2.146 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.099208e-03 2.149 0 0
Depyrimidination R-HSA-73928 7.099208e-03 2.149 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.299673e-03 2.137 0 0
Cleavage of the damaged purine R-HSA-110331 7.299673e-03 2.137 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.324247e-03 2.135 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.718368e-03 2.112 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.797476e-03 2.108 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.797476e-03 2.108 0 0
Synthesis of DNA R-HSA-69239 8.035804e-03 2.095 0 0
Gene Silencing by RNA R-HSA-211000 8.035804e-03 2.095 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.102301e-03 2.091 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.102301e-03 2.091 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.215520e-03 2.085 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.323806e-03 2.080 0 0
Depurination R-HSA-73927 8.534021e-03 2.069 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.587762e-03 2.066 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.587762e-03 2.066 0 0
Gap junction degradation R-HSA-190873 8.956503e-03 2.048 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.956503e-03 2.048 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.956503e-03 2.048 0 0
Signaling by Hippo R-HSA-2028269 8.963957e-03 2.048 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.065659e-03 2.043 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.464515e-03 2.024 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.602021e-03 2.018 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.026215e-02 1.989 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.229612e-02 1.910 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.220157e-02 1.914 0 0
Ephrin signaling R-HSA-3928664 1.121611e-02 1.950 0 0
mTORC1-mediated signalling R-HSA-166208 9.921846e-03 2.003 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.202845e-02 1.920 0 0
Late endosomal microautophagy R-HSA-9615710 1.219963e-02 1.914 0 0
Dual Incision in GG-NER R-HSA-5696400 1.196477e-02 1.922 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.240061e-02 1.907 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.152746e-02 1.938 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.107292e-02 1.956 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.070223e-02 1.971 0 0
HCMV Early Events R-HSA-9609690 1.212944e-02 1.916 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.006896e-02 1.997 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.999208e-03 2.000 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.999208e-03 2.000 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.220157e-02 1.914 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.196477e-02 1.922 0 0
TCR signaling R-HSA-202403 1.045771e-02 1.981 0 0
L1CAM interactions R-HSA-373760 1.106433e-02 1.956 0 0
Orc1 removal from chromatin R-HSA-68949 1.152746e-02 1.938 0 0
Nuclear import of Rev protein R-HSA-180746 1.196477e-02 1.922 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.026215e-02 1.989 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.148200e-02 1.940 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.921846e-03 2.003 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.220157e-02 1.914 0 0
Signaling by WNT R-HSA-195721 1.178617e-02 1.929 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.121611e-02 1.950 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.924098e-03 2.003 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.148200e-02 1.940 0 0
Pexophagy R-HSA-9664873 1.229612e-02 1.910 0 0
Maturation of protein E R-HSA-9683683 1.026215e-02 1.989 0 0
Maturation of protein E R-HSA-9694493 1.026215e-02 1.989 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.026215e-02 1.989 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.303756e-02 1.885 0 0
FLT3 Signaling R-HSA-9607240 1.321993e-02 1.879 0 0
Ribosome-associated quality control R-HSA-9948299 1.350017e-02 1.870 0 0
Neutrophil degranulation R-HSA-6798695 1.362027e-02 1.866 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.366261e-02 1.864 0 0
Amyloid fiber formation R-HSA-977225 1.368161e-02 1.864 0 0
Generic Transcription Pathway R-HSA-212436 1.370392e-02 1.863 0 0
Signaling by NOTCH4 R-HSA-9013694 1.373175e-02 1.862 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.391605e-02 1.856 0 0
Glycolysis R-HSA-70171 1.422885e-02 1.847 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.438092e-02 1.842 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.444647e-02 1.840 0 0
Peptide chain elongation R-HSA-156902 1.485646e-02 1.828 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.489496e-02 1.827 0 0
Nef and signal transduction R-HSA-164944 1.517064e-02 1.819 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.549931e-02 1.810 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.549931e-02 1.810 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.549931e-02 1.810 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.549931e-02 1.810 0 0
Translesion synthesis by REV1 R-HSA-110312 1.549931e-02 1.810 0 0
p75NTR signals via NF-kB R-HSA-193639 1.549931e-02 1.810 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.583867e-02 1.800 0 0
FLT3 signaling in disease R-HSA-9682385 1.609605e-02 1.793 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.639168e-02 1.785 0 0
Signaling by NOTCH3 R-HSA-9012852 1.650973e-02 1.782 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.683724e-02 1.774 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.683724e-02 1.774 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.683724e-02 1.774 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.685346e-02 1.773 0 0
Negative regulation of MET activity R-HSA-6807004 1.690355e-02 1.772 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.690355e-02 1.772 0 0
Nephrin family interactions R-HSA-373753 1.690355e-02 1.772 0 0
Eukaryotic Translation Termination R-HSA-72764 1.734673e-02 1.761 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.734673e-02 1.761 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.805248e-02 1.743 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.817678e-02 1.740 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.848914e-02 1.733 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.851947e-02 1.732 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.851947e-02 1.732 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.864583e-02 1.729 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.866754e-02 1.729 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.866754e-02 1.729 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.866754e-02 1.729 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.876778e-02 1.727 0 0
Translesion synthesis by POLI R-HSA-5656121 1.936761e-02 1.713 0 0
Phosphorylation of the APC/C R-HSA-176412 1.936761e-02 1.713 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.936761e-02 1.713 0 0
Negative regulation of FLT3 R-HSA-9706369 1.936761e-02 1.713 0 0
G0 and Early G1 R-HSA-1538133 1.958670e-02 1.708 0 0
Myogenesis R-HSA-525793 2.031112e-02 1.692 0 0
Telomere Maintenance R-HSA-157579 2.051854e-02 1.688 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.538176e-02 1.595 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.708911e-02 1.567 0 0
Disorders of Nervous System Development R-HSA-9697154 2.708911e-02 1.567 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.708911e-02 1.567 0 0
Pervasive developmental disorders R-HSA-9005895 2.708911e-02 1.567 0 0
Disorders of Developmental Biology R-HSA-9675151 2.384589e-02 1.623 0 0
Translesion synthesis by POLK R-HSA-5655862 2.384589e-02 1.623 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.437362e-02 1.613 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.437362e-02 1.613 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.264681e-02 1.645 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.264681e-02 1.645 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.603432e-02 1.584 0 0
mRNA 3'-end processing R-HSA-72187 2.544410e-02 1.594 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.544410e-02 1.594 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.530140e-02 1.597 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.701798e-02 1.568 0 0
Nucleotide Excision Repair R-HSA-5696398 2.321514e-02 1.634 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.739183e-02 1.562 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.516836e-02 1.599 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.708911e-02 1.567 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.769459e-02 1.558 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.739183e-02 1.562 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.130526e-02 1.672 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.380257e-02 1.623 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.810362e-02 1.551 0 0
G1/S Transition R-HSA-69206 2.361968e-02 1.627 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.437362e-02 1.613 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.544410e-02 1.594 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.120068e-02 1.674 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.708911e-02 1.567 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.739183e-02 1.562 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.264681e-02 1.645 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.603432e-02 1.584 0 0
Viral Infection Pathways R-HSA-9824446 2.313545e-02 1.636 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.822777e-02 1.549 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.822777e-02 1.549 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.822777e-02 1.549 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.822777e-02 1.549 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.822777e-02 1.549 0 0
Signaling by Interleukins R-HSA-449147 2.287069e-02 1.641 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.686371e-02 1.571 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.834019e-02 1.548 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.834019e-02 1.548 0 0
Signaling by ROBO receptors R-HSA-376176 2.856898e-02 1.544 0 0
Notch-HLH transcription pathway R-HSA-350054 2.884651e-02 1.540 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.884651e-02 1.540 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.886342e-02 1.540 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.886342e-02 1.540 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.886342e-02 1.540 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.886342e-02 1.540 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.896902e-02 1.538 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.934110e-02 1.533 0 0
SARS-CoV Infections R-HSA-9679506 2.937838e-02 1.532 0 0
HIV Infection R-HSA-162906 2.955809e-02 1.529 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.976507e-02 1.526 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.976507e-02 1.526 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.984423e-02 1.525 0 0
HIV Life Cycle R-HSA-162587 3.019443e-02 1.520 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.092794e-02 1.510 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.092794e-02 1.510 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.143484e-02 1.503 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.146777e-02 1.502 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.200614e-02 1.495 0 0
Cellular response to starvation R-HSA-9711097 3.202964e-02 1.494 0 0
Translation R-HSA-72766 3.238065e-02 1.490 0 0
Base Excision Repair R-HSA-73884 3.302208e-02 1.481 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.378490e-02 1.471 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.385382e-02 1.470 0 0
Regulation of Apoptosis R-HSA-169911 3.385382e-02 1.470 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.476678e-02 1.459 0 0
MAP2K and MAPK activation R-HSA-5674135 3.477404e-02 1.459 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.520984e-02 1.453 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.687402e-02 1.433 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.719590e-02 1.430 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.739492e-02 1.427 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.739492e-02 1.427 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.739492e-02 1.427 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.739492e-02 1.427 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.776543e-02 1.423 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.776543e-02 1.423 0 0
G1/S-Specific Transcription R-HSA-69205 3.831414e-02 1.417 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.845169e-02 1.415 0 0
TNF signaling R-HSA-75893 3.845169e-02 1.415 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.857307e-02 1.414 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.857307e-02 1.414 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.946779e-02 1.404 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.946779e-02 1.404 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.056493e-02 1.392 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.126350e-02 1.384 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.126350e-02 1.384 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.142330e-02 1.383 0 0
EGFR downregulation R-HSA-182971 4.195466e-02 1.377 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.195466e-02 1.377 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.232397e-02 1.373 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.343993e-02 1.362 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.356392e-02 1.361 0 0
Regulation of TP53 Expression R-HSA-6804754 6.561994e-02 1.183 0 0
Diseases of cellular response to stress R-HSA-9675132 6.561994e-02 1.183 0 0
Diseases of Cellular Senescence R-HSA-9630747 6.561994e-02 1.183 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 6.561994e-02 1.183 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.181237e-02 1.286 0 0
2-LTR circle formation R-HSA-164843 4.807131e-02 1.318 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.807131e-02 1.318 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.002386e-02 1.301 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.847779e-02 1.314 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.847779e-02 1.314 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.847779e-02 1.314 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.847779e-02 1.314 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.847779e-02 1.314 0 0
Long-term potentiation R-HSA-9620244 4.548584e-02 1.342 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.942349e-02 1.226 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.942349e-02 1.226 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.376142e-02 1.270 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.403963e-02 1.267 0 0
Dual incision in TC-NER R-HSA-6782135 4.645954e-02 1.333 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.491600e-02 1.188 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.732983e-02 1.325 0 0
Centrosome maturation R-HSA-380287 5.552984e-02 1.255 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.052309e-02 1.297 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.249275e-02 1.204 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.642241e-02 1.249 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.391620e-02 1.194 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.391620e-02 1.194 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.391620e-02 1.194 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.830742e-02 1.234 0 0
Regulation of CDH11 function R-HSA-9762292 4.807131e-02 1.318 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.510423e-02 1.186 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.762002e-02 1.322 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.349591e-02 1.272 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.399575e-02 1.194 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.807131e-02 1.318 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.468228e-02 1.262 0 0
UCH proteinases R-HSA-5689603 5.997293e-02 1.222 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.649936e-02 1.248 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.649936e-02 1.248 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.756671e-02 1.323 0 0
HCMV Infection R-HSA-9609646 5.774172e-02 1.239 0 0
Protein methylation R-HSA-8876725 5.002386e-02 1.301 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.642241e-02 1.249 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.376142e-02 1.270 0 0
Downstream TCR signaling R-HSA-202424 5.830742e-02 1.234 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.346716e-02 1.272 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.346716e-02 1.272 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.346716e-02 1.272 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.346716e-02 1.272 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.050838e-02 1.218 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.361646e-02 1.271 0 0
Basigin interactions R-HSA-210991 5.642241e-02 1.249 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.038746e-02 1.219 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.756671e-02 1.323 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.901085e-02 1.229 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.234347e-02 1.281 0 0
Signaling by NOTCH1 R-HSA-1980143 5.997293e-02 1.222 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.510423e-02 1.186 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.002386e-02 1.301 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.942349e-02 1.226 0 0
Cellular response to chemical stress R-HSA-9711123 6.041362e-02 1.219 0 0
Glucose metabolism R-HSA-70326 6.032603e-02 1.219 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.002386e-02 1.301 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.618126e-02 1.250 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.744084e-02 1.324 0 0
tRNA processing in the nucleus R-HSA-6784531 6.575613e-02 1.182 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.656550e-02 1.177 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.656550e-02 1.177 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.656550e-02 1.177 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.728273e-02 1.172 0 0
Signaling by NOTCH2 R-HSA-1980145 6.750434e-02 1.171 0 0
Mitophagy R-HSA-5205647 6.750434e-02 1.171 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.750434e-02 1.171 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.795114e-02 1.168 0 0
Muscle contraction R-HSA-397014 6.844206e-02 1.165 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.013528e-02 1.154 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.013528e-02 1.154 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.013528e-02 1.154 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.013528e-02 1.154 0 0
Vesicle-mediated transport R-HSA-5653656 7.033709e-02 1.153 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.129319e-02 1.147 0 0
Signaling by PTK6 R-HSA-8848021 7.129319e-02 1.147 0 0
Platelet degranulation R-HSA-114608 7.149897e-02 1.146 0 0
Activation of RAC1 R-HSA-428540 7.284926e-02 1.138 0 0
Integration of provirus R-HSA-162592 7.284926e-02 1.138 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.329565e-02 1.135 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.345901e-02 1.134 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.345901e-02 1.134 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.345901e-02 1.134 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.452429e-02 1.128 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.452429e-02 1.128 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.511583e-02 1.124 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.511583e-02 1.124 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.511583e-02 1.124 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.572195e-02 1.121 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.572195e-02 1.121 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.572195e-02 1.121 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.572195e-02 1.121 0 0
Developmental Biology R-HSA-1266738 7.627041e-02 1.118 1 0
ABC-family proteins mediated transport R-HSA-382556 7.652922e-02 1.116 0 0
DNA Damage Bypass R-HSA-73893 7.782739e-02 1.109 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.077685e-02 1.093 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.077685e-02 1.093 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.083458e-02 1.092 0 0
Interleukin-1 signaling R-HSA-9020702 8.134216e-02 1.090 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.163214e-02 1.088 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.163214e-02 1.088 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.322323e-02 1.080 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.467794e-02 1.072 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.476122e-02 1.072 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.476122e-02 1.072 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.476122e-02 1.072 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.724678e-02 1.059 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.724678e-02 1.059 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.724678e-02 1.059 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.724678e-02 1.059 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.724678e-02 1.059 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.724678e-02 1.059 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.730697e-02 1.059 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.730697e-02 1.059 0 0
Recycling of eIF2:GDP R-HSA-72731 8.730697e-02 1.059 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.730697e-02 1.059 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.851976e-02 1.053 0 0
Degradation of DVL R-HSA-4641258 9.182540e-02 1.037 0 0
Degradation of AXIN R-HSA-4641257 9.182540e-02 1.037 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.182540e-02 1.037 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.406448e-02 1.027 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.406448e-02 1.027 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.438923e-02 1.025 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.438923e-02 1.025 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.438923e-02 1.025 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.555509e-02 1.020 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.594956e-02 1.018 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.641779e-02 1.016 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.668674e-02 1.015 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.734167e-02 1.012 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.750164e-02 1.011 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.750164e-02 1.011 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.782894e-02 1.010 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 9.856984e-02 1.006 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.856984e-02 1.006 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.856984e-02 1.006 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 9.856984e-02 1.006 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.856984e-02 1.006 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.856984e-02 1.006 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.009188e-01 0.996 0 0
Kinesins R-HSA-983189 1.021142e-01 0.991 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.029046e-01 0.988 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.029046e-01 0.988 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.033949e-01 0.986 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.038979e-01 0.983 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.045982e-01 0.980 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.052750e-01 0.978 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.052750e-01 0.978 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.052750e-01 0.978 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.071027e-01 0.970 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.071405e-01 0.970 0 0
HDMs demethylate histones R-HSA-3214842 1.071405e-01 0.970 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.074025e-01 0.969 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.093838e-01 0.961 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.093838e-01 0.961 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.093838e-01 0.961 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.107801e-01 0.956 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.153769e-01 0.938 0 0
G-protein beta:gamma signalling R-HSA-397795 1.153769e-01 0.938 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.153769e-01 0.938 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.153769e-01 0.938 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.153769e-01 0.938 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.874289e-01 0.727 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.874289e-01 0.727 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.874289e-01 0.727 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.874289e-01 0.727 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.874289e-01 0.727 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.874289e-01 0.727 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.874289e-01 0.727 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.874289e-01 0.727 0 0
Hereditary fructose intolerance R-HSA-5657560 1.874289e-01 0.727 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.874289e-01 0.727 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.874289e-01 0.727 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.874289e-01 0.727 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.874289e-01 0.727 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.874289e-01 0.727 0 0
Regulation of gap junction activity R-HSA-191650 1.293800e-01 0.888 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.293800e-01 0.888 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.293800e-01 0.888 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.293800e-01 0.888 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.293800e-01 0.888 0 0
IRS activation R-HSA-74713 1.650061e-01 0.782 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.650061e-01 0.782 0 0
Lipophagy R-HSA-9613354 1.304042e-01 0.885 0 0
ALK mutants bind TKIs R-HSA-9700645 1.304042e-01 0.885 0 0
Phosphorylation of Emi1 R-HSA-176417 2.020709e-01 0.694 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.020709e-01 0.694 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.020709e-01 0.694 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.542552e-01 0.812 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.542552e-01 0.812 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.216087e-01 0.915 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.566228e-01 0.805 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.566228e-01 0.805 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.566228e-01 0.805 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.054216e-01 0.687 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.054216e-01 0.687 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.054216e-01 0.687 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.366391e-01 0.864 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.764606e-01 0.753 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.322942e-01 0.634 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.322942e-01 0.634 0 0
Polymerase switching R-HSA-69091 2.322942e-01 0.634 0 0
Leading Strand Synthesis R-HSA-69109 2.322942e-01 0.634 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.322942e-01 0.634 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.322942e-01 0.634 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.322942e-01 0.634 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.322942e-01 0.634 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.322942e-01 0.634 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.322942e-01 0.634 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.524439e-01 0.817 0 0
Cristae formation R-HSA-8949613 1.323509e-01 0.878 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.970921e-01 0.705 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.970921e-01 0.705 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.459228e-01 0.836 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.267113e-01 0.897 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.600974e-01 0.796 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.600974e-01 0.796 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.039390e-01 0.690 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.638627e-01 0.786 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.534681e-01 0.814 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.220766e-01 0.653 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.343723e-01 0.872 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.826701e-01 0.738 0 0
Viral mRNA Translation R-HSA-192823 1.427416e-01 0.845 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.528564e-01 0.816 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.510472e-01 0.821 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.042694e-01 0.690 0 0
RNA Polymerase III Transcription R-HSA-74158 1.638627e-01 0.786 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.176497e-01 0.929 0 0
Signaling by EGFR R-HSA-177929 1.346380e-01 0.871 0 0
RAF activation R-HSA-5673000 1.385841e-01 0.858 0 0
PERK regulates gene expression R-HSA-381042 1.509754e-01 0.821 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.054216e-01 0.687 0 0
DCC mediated attractive signaling R-HSA-418885 1.376841e-01 0.861 0 0
Metalloprotease DUBs R-HSA-5689901 1.194139e-01 0.923 0 0
Generation of second messenger molecules R-HSA-202433 2.198510e-01 0.658 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.515707e-01 0.819 0 0
Post NMDA receptor activation events R-HSA-438064 1.321165e-01 0.879 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 1.650061e-01 0.782 0 0
PI3K/AKT activation R-HSA-198203 1.542552e-01 0.812 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.689682e-01 0.772 0 0
DNA strand elongation R-HSA-69190 2.058701e-01 0.686 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.183032e-01 0.927 0 0
Co-stimulation by CD28 R-HSA-389356 1.335142e-01 0.874 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.323509e-01 0.878 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.385841e-01 0.858 0 0
Protein localization R-HSA-9609507 1.826447e-01 0.738 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.376841e-01 0.861 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.376841e-01 0.861 0 0
Budding and maturation of HIV virion R-HSA-162588 1.901103e-01 0.721 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.652851e-01 0.782 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.162465e-01 0.935 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.575108e-01 0.803 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.575108e-01 0.803 0 0
Repression of WNT target genes R-HSA-4641265 2.322942e-01 0.634 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.031772e-01 0.692 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.125550e-01 0.673 0 0
Gap junction trafficking and regulation R-HSA-157858 1.437261e-01 0.842 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.094017e-01 0.679 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.563443e-01 0.806 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.650061e-01 0.782 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.184101e-01 0.661 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.220766e-01 0.653 0 0
Gap junction trafficking R-HSA-190828 1.775521e-01 0.751 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.263701e-01 0.645 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.263701e-01 0.645 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.020709e-01 0.694 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.197462e-01 0.922 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.216087e-01 0.915 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 1.689682e-01 0.772 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.793373e-01 0.746 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.268673e-01 0.897 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.239782e-01 0.907 0 0
MAPK family signaling cascades R-HSA-5683057 1.467976e-01 0.833 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.874289e-01 0.727 0 0
Inhibition of PKR R-HSA-169131 1.874289e-01 0.727 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.293800e-01 0.888 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.293800e-01 0.888 0 0
Unwinding of DNA R-HSA-176974 1.304042e-01 0.885 0 0
Regulation of KIT signaling R-HSA-1433559 1.197462e-01 0.922 0 0
Bicarbonate transporters R-HSA-425381 1.793361e-01 0.746 0 0
Protein hydroxylation R-HSA-9629569 1.216087e-01 0.915 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.566228e-01 0.805 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.970921e-01 0.705 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.184101e-01 0.661 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.385841e-01 0.858 0 0
Cellular response to hypoxia R-HSA-1234174 1.438096e-01 0.842 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.856835e-01 0.731 0 0
MHC class II antigen presentation R-HSA-2132295 1.876913e-01 0.727 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.112805e-01 0.675 0 0
Neurexins and neuroligins R-HSA-6794361 1.766062e-01 0.753 0 0
HCMV Late Events R-HSA-9610379 1.527861e-01 0.816 0 0
MAP kinase activation R-HSA-450294 1.856835e-01 0.731 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.167754e-01 0.933 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.005183e-01 0.698 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.366391e-01 0.864 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.656543e-01 0.781 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.334349e-01 0.875 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.304042e-01 0.885 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.304042e-01 0.885 0 0
Suppression of apoptosis R-HSA-9635465 1.793361e-01 0.746 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.194139e-01 0.923 0 0
Death Receptor Signaling R-HSA-73887 1.353600e-01 0.869 0 0
Signaling by TGFB family members R-HSA-9006936 1.218424e-01 0.914 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.258394e-01 0.646 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.304042e-01 0.885 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.020709e-01 0.694 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.970921e-01 0.705 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.420520e-01 0.848 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.420520e-01 0.848 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.770719e-01 0.752 0 0
Immune System R-HSA-168256 1.556625e-01 0.808 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.251431e-01 0.648 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.437261e-01 0.842 0 0
Formation of definitive endoderm R-HSA-9823730 1.216087e-01 0.915 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.385841e-01 0.858 0 0
Regulation of beta-cell development R-HSA-186712 1.642984e-01 0.784 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.910250e-01 0.719 0 0
TGFBR3 expression R-HSA-9839394 2.222603e-01 0.653 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.772215e-01 0.751 0 0
Hedgehog 'off' state R-HSA-5610787 1.855475e-01 0.732 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.454335e-01 0.837 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.669693e-01 0.777 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.293800e-01 0.888 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.267113e-01 0.897 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.861538e-01 0.730 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.165861e-01 0.933 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.220766e-01 0.653 0 0
PCP/CE pathway R-HSA-4086400 1.891670e-01 0.723 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.748393e-01 0.757 0 0
Mitochondrial biogenesis R-HSA-1592230 1.442311e-01 0.841 0 0
Hedgehog 'on' state R-HSA-5632684 1.261943e-01 0.899 0 0
PECAM1 interactions R-HSA-210990 1.793361e-01 0.746 0 0
Selenocysteine synthesis R-HSA-2408557 1.287786e-01 0.890 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.376841e-01 0.861 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.199184e-01 0.658 0 0
Gluconeogenesis R-HSA-70263 1.335142e-01 0.874 0 0
Sensory processing of sound R-HSA-9659379 1.991890e-01 0.701 0 0
Neurodegenerative Diseases R-HSA-8863678 2.039390e-01 0.690 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.039390e-01 0.690 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.366391e-01 0.864 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.323509e-01 0.878 0 0
Inositol phosphate metabolism R-HSA-1483249 2.240691e-01 0.650 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.650061e-01 0.782 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.764606e-01 0.753 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.184101e-01 0.661 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.542552e-01 0.812 0 0
Translation of Structural Proteins R-HSA-9683701 1.420520e-01 0.848 0 0
Regulation of BACH1 activity R-HSA-9708530 1.566228e-01 0.805 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.346380e-01 0.871 0 0
Glycogen storage diseases R-HSA-3229121 1.970921e-01 0.705 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.331516e-01 0.632 0 0
Signaling by ERBB4 R-HSA-1236394 2.372216e-01 0.625 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.386861e-01 0.622 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.386861e-01 0.622 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.399451e-01 0.620 0 0
Signaling by LTK in cancer R-HSA-9842640 2.399451e-01 0.620 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.399451e-01 0.620 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.399451e-01 0.620 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.399451e-01 0.620 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 2.399451e-01 0.620 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 2.399451e-01 0.620 0 0
Neurofascin interactions R-HSA-447043 2.399451e-01 0.620 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.399451e-01 0.620 0 0
CREB phosphorylation R-HSA-199920 2.399451e-01 0.620 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.399451e-01 0.620 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.403070e-01 0.619 0 0
Rap1 signalling R-HSA-392517 2.403070e-01 0.619 0 0
Other interleukin signaling R-HSA-449836 2.403070e-01 0.619 0 0
Maturation of nucleoprotein R-HSA-9694631 2.403070e-01 0.619 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.410526e-01 0.618 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.410526e-01 0.618 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.410526e-01 0.618 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.500967e-01 0.602 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.532047e-01 0.597 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.532047e-01 0.597 0 0
IRE1alpha activates chaperones R-HSA-381070 2.555551e-01 0.593 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.583442e-01 0.588 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.597476e-01 0.585 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.597476e-01 0.585 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.597476e-01 0.585 0 0
Formation of axial mesoderm R-HSA-9796292 2.597476e-01 0.585 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.597476e-01 0.585 0 0
Maturation of nucleoprotein R-HSA-9683610 2.597476e-01 0.585 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.602505e-01 0.585 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.602505e-01 0.585 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.602505e-01 0.585 0 0
Insulin processing R-HSA-264876 2.602505e-01 0.585 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.626765e-01 0.581 0 0
Signal transduction by L1 R-HSA-445144 2.626765e-01 0.581 0 0
Glycogen synthesis R-HSA-3322077 2.626765e-01 0.581 0 0
Signaling by Hedgehog R-HSA-5358351 2.639029e-01 0.579 0 0
Protein folding R-HSA-391251 2.663394e-01 0.575 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.675333e-01 0.573 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.675333e-01 0.573 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.675333e-01 0.573 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.675333e-01 0.573 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.675333e-01 0.573 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.675333e-01 0.573 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.675333e-01 0.573 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.675333e-01 0.573 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.675333e-01 0.573 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.675333e-01 0.573 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.675333e-01 0.573 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.697882e-01 0.569 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.729354e-01 0.564 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.781093e-01 0.556 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.781093e-01 0.556 0 0
SOS-mediated signalling R-HSA-112412 2.781093e-01 0.556 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.781093e-01 0.556 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.781093e-01 0.556 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.781093e-01 0.556 0 0
CHL1 interactions R-HSA-447041 2.781093e-01 0.556 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.781093e-01 0.556 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.781093e-01 0.556 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.795188e-01 0.554 0 0
HIV elongation arrest and recovery R-HSA-167287 2.797883e-01 0.553 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.797883e-01 0.553 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.797883e-01 0.553 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.797883e-01 0.553 0 0
ABC transporter disorders R-HSA-5619084 2.847199e-01 0.546 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.854145e-01 0.545 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.854145e-01 0.545 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.868254e-01 0.542 0 0
Zinc transporters R-HSA-435354 2.875885e-01 0.541 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.894308e-01 0.538 0 0
Interleukin-17 signaling R-HSA-448424 2.948313e-01 0.530 0 0
Cyclin D associated events in G1 R-HSA-69231 2.975566e-01 0.526 0 0
G1 Phase R-HSA-69236 2.975566e-01 0.526 0 0
RMTs methylate histone arginines R-HSA-3214858 2.975566e-01 0.526 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.995639e-01 0.524 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.996012e-01 0.523 0 0
Assembly Of The HIV Virion R-HSA-175474 3.084207e-01 0.511 0 0
Adaptive Immune System R-HSA-1280218 3.152787e-01 0.501 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.156380e-01 0.501 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.156380e-01 0.501 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.161387e-01 0.500 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.161387e-01 0.500 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.161387e-01 0.500 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.161387e-01 0.500 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.161387e-01 0.500 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.161387e-01 0.500 0 0
Adrenoceptors R-HSA-390696 3.161387e-01 0.500 0 0
Activation of the pre-replicative complex R-HSA-68962 3.196256e-01 0.495 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.196256e-01 0.495 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.196256e-01 0.495 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.197523e-01 0.495 0 0
ER-Phagosome pathway R-HSA-1236974 3.223522e-01 0.492 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.301992e-01 0.481 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.301992e-01 0.481 0 0
Signaling by TGFBR3 R-HSA-9839373 3.301992e-01 0.481 0 0
Diseases of DNA repair R-HSA-9675135 3.301992e-01 0.481 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.315986e-01 0.479 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.315986e-01 0.479 0 0
Cilium Assembly R-HSA-5617833 3.367854e-01 0.473 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.397452e-01 0.469 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.397452e-01 0.469 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.397452e-01 0.469 0 0
Signalling to ERK5 R-HSA-198765 3.397452e-01 0.469 0 0
C6 deamination of adenosine R-HSA-75102 3.397452e-01 0.469 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.397452e-01 0.469 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.397452e-01 0.469 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.397452e-01 0.469 0 0
Trafficking of AMPA receptors R-HSA-399719 3.397993e-01 0.469 0 0
Atorvastatin ADME R-HSA-9754706 3.437325e-01 0.464 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.437325e-01 0.464 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.442906e-01 0.463 0 0
Signaling by ALK R-HSA-201556 3.442906e-01 0.463 0 0
Toll-like Receptor Cascades R-HSA-168898 3.451305e-01 0.462 0 0
Ion homeostasis R-HSA-5578775 3.478929e-01 0.459 0 0
ARMS-mediated activation R-HSA-170984 3.536892e-01 0.451 0 0
Calcineurin activates NFAT R-HSA-2025928 3.536892e-01 0.451 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.536892e-01 0.451 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.536892e-01 0.451 0 0
Regulation of signaling by NODAL R-HSA-1433617 3.536892e-01 0.451 1 1
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.536892e-01 0.451 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.536892e-01 0.451 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.536892e-01 0.451 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.536892e-01 0.451 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.536892e-01 0.451 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.548569e-01 0.450 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.548569e-01 0.450 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.548569e-01 0.450 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.557549e-01 0.449 0 0
Iron uptake and transport R-HSA-917937 3.615980e-01 0.442 0 0
Glycogen metabolism R-HSA-8982491 3.624653e-01 0.441 0 0
Circadian clock R-HSA-9909396 3.703149e-01 0.431 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.717242e-01 0.430 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.717242e-01 0.430 0 0
Synthesis of PG R-HSA-1483148 3.717242e-01 0.430 0 0
Deadenylation of mRNA R-HSA-429947 3.781096e-01 0.422 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.781096e-01 0.422 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.781096e-01 0.422 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.781096e-01 0.422 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.781096e-01 0.422 0 0
Integrin signaling R-HSA-354192 3.803574e-01 0.420 0 0
Nuclear RNA decay R-HSA-9930044 3.803574e-01 0.420 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.803574e-01 0.420 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.803574e-01 0.420 0 0
Cardiogenesis R-HSA-9733709 3.803574e-01 0.420 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.803574e-01 0.420 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.806890e-01 0.419 0 0
Signal attenuation R-HSA-74749 3.904858e-01 0.408 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.904858e-01 0.408 0 0
Signaling by Leptin R-HSA-2586552 3.904858e-01 0.408 0 0
Regulated Necrosis R-HSA-5218859 3.915734e-01 0.407 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.994805e-01 0.399 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.994805e-01 0.399 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.012766e-01 0.397 0 0
Interleukin-7 signaling R-HSA-1266695 4.012766e-01 0.397 0 0
Interleukin-1 family signaling R-HSA-446652 4.039974e-01 0.394 0 0
MET interacts with TNS proteins R-HSA-8875513 4.048418e-01 0.393 0 0
Axonal growth stimulation R-HSA-209563 4.048418e-01 0.393 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.048418e-01 0.393 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.048418e-01 0.393 0 0
MET activates PTPN11 R-HSA-8865999 4.048418e-01 0.393 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.048418e-01 0.393 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.048418e-01 0.393 0 0
MET activates STAT3 R-HSA-8875791 4.048418e-01 0.393 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.048418e-01 0.393 0 0
Histamine receptors R-HSA-390650 4.048418e-01 0.393 0 0
Ca-dependent events R-HSA-111996 4.171232e-01 0.380 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.208265e-01 0.376 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.208265e-01 0.376 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.208265e-01 0.376 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.242837e-01 0.372 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.242837e-01 0.372 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.242837e-01 0.372 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.251772e-01 0.371 0 0
Signaling by APC mutants R-HSA-4839744 4.263124e-01 0.370 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.263124e-01 0.370 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.263124e-01 0.370 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.263124e-01 0.370 0 0
Formation of the posterior neural plate R-HSA-9832991 4.263124e-01 0.370 0 0
Synthesis of PI R-HSA-1483226 4.263124e-01 0.370 0 0
vRNP Assembly R-HSA-192905 4.263124e-01 0.370 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.263124e-01 0.370 0 0
LGI-ADAM interactions R-HSA-5682910 4.263124e-01 0.370 0 0
Interleukin-2 signaling R-HSA-9020558 4.263124e-01 0.370 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.263124e-01 0.370 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.268844e-01 0.370 0 0
GAB1 signalosome R-HSA-180292 4.268844e-01 0.370 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.320928e-01 0.364 0 0
Signaling by SCF-KIT R-HSA-1433557 4.352577e-01 0.361 0 0
Signaling by FGFR4 R-HSA-5654743 4.352577e-01 0.361 0 0
Mitochondrial protein import R-HSA-1268020 4.406238e-01 0.356 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.433650e-01 0.353 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.538334e-01 0.343 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.538334e-01 0.343 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.538334e-01 0.343 0 0
CaM pathway R-HSA-111997 4.608033e-01 0.336 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.608033e-01 0.336 0 0
Calmodulin induced events R-HSA-111933 4.608033e-01 0.336 0 0
GPVI-mediated activation cascade R-HSA-114604 4.608033e-01 0.336 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.610026e-01 0.336 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.610026e-01 0.336 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.610026e-01 0.336 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.610026e-01 0.336 0 0
Signaling by AXIN mutants R-HSA-4839735 4.610026e-01 0.336 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.610026e-01 0.336 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.610026e-01 0.336 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.610026e-01 0.336 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.625302e-01 0.335 0 0
HCN channels R-HSA-1296061 4.635237e-01 0.334 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.635237e-01 0.334 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.635237e-01 0.334 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.635237e-01 0.334 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.635237e-01 0.334 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.635237e-01 0.334 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.635237e-01 0.334 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.635237e-01 0.334 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.635237e-01 0.334 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.635237e-01 0.334 0 0
NADE modulates death signalling R-HSA-205025 4.635237e-01 0.334 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.635237e-01 0.334 0 0
Ca2+ pathway R-HSA-4086398 4.639838e-01 0.333 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.695519e-01 0.328 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.695519e-01 0.328 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.711852e-01 0.327 0 0
DAG and IP3 signaling R-HSA-1489509 4.711852e-01 0.327 0 0
Somitogenesis R-HSA-9824272 4.711852e-01 0.327 0 0
Signaling by FGFR3 R-HSA-5654741 4.711852e-01 0.327 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.768217e-01 0.322 0 0
Potential therapeutics for SARS R-HSA-9679191 4.778362e-01 0.321 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.802388e-01 0.319 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.802388e-01 0.319 0 0
Signaling by Erythropoietin R-HSA-9006335 4.916954e-01 0.308 0 0
Platelet calcium homeostasis R-HSA-418360 4.916954e-01 0.308 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.916954e-01 0.308 0 0
Rab regulation of trafficking R-HSA-9007101 4.922136e-01 0.308 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.944323e-01 0.306 0 0
Signaling by LTK R-HSA-9842663 4.944323e-01 0.306 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.944323e-01 0.306 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.999359e-01 0.301 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.047504e-01 0.297 0 0
Lagging Strand Synthesis R-HSA-69186 5.060253e-01 0.296 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.064457e-01 0.295 0 0
DAP12 signaling R-HSA-2424491 5.134436e-01 0.290 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.134436e-01 0.290 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.134436e-01 0.290 0 0
G2 Phase R-HSA-68911 5.164228e-01 0.287 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.164228e-01 0.287 0 0
Defective F9 activation R-HSA-9673221 5.164228e-01 0.287 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.164228e-01 0.287 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.164228e-01 0.287 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.164228e-01 0.287 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.164228e-01 0.287 0 0
Activation of AKT2 R-HSA-165158 5.164228e-01 0.287 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.164228e-01 0.287 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.164228e-01 0.287 0 0
NrCAM interactions R-HSA-447038 5.164228e-01 0.287 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.164228e-01 0.287 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.164228e-01 0.287 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.164228e-01 0.287 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.164228e-01 0.287 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.190902e-01 0.285 0 0
RAS processing R-HSA-9648002 5.190902e-01 0.285 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.190902e-01 0.285 0 0
Selenoamino acid metabolism R-HSA-2408522 5.205636e-01 0.284 0 0
Translation of Structural Proteins R-HSA-9694635 5.207515e-01 0.283 0 0
Metal ion SLC transporters R-HSA-425410 5.237542e-01 0.281 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.265129e-01 0.279 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.265129e-01 0.279 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.311299e-01 0.275 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.311603e-01 0.275 0 0
Pyruvate metabolism R-HSA-70268 5.376522e-01 0.269 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.379256e-01 0.269 0 0
HIV Transcription Elongation R-HSA-167169 5.379256e-01 0.269 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.379256e-01 0.269 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.379256e-01 0.269 0 0
Extension of Telomeres R-HSA-180786 5.434938e-01 0.265 0 0
Peroxisomal protein import R-HSA-9033241 5.434938e-01 0.265 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.434938e-01 0.265 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.434938e-01 0.265 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.455732e-01 0.263 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.483894e-01 0.261 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.555008e-01 0.255 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.555008e-01 0.255 0 0
Signaling by KIT in disease R-HSA-9669938 5.555008e-01 0.255 0 0
Signaling by WNT in cancer R-HSA-4791275 5.555838e-01 0.255 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.555838e-01 0.255 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.564130e-01 0.255 0 0
Removal of the Flap Intermediate R-HSA-69166 5.571853e-01 0.254 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.571853e-01 0.254 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.571853e-01 0.254 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.571853e-01 0.254 0 0
Malate-aspartate shuttle R-HSA-9856872 5.571853e-01 0.254 0 0
Signal regulatory protein family interactions R-HSA-391160 5.571853e-01 0.254 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.571853e-01 0.254 0 0
Signaling by MET R-HSA-6806834 5.619727e-01 0.250 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.641086e-01 0.249 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.641086e-01 0.249 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.641086e-01 0.249 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.641086e-01 0.249 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.641086e-01 0.249 0 0
PDE3B signalling R-HSA-165160 5.641086e-01 0.249 0 0
PKB-mediated events R-HSA-109703 5.641086e-01 0.249 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.641086e-01 0.249 0 0
Cam-PDE 1 activation R-HSA-111957 5.641086e-01 0.249 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.641086e-01 0.249 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.641086e-01 0.249 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.641086e-01 0.249 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.641086e-01 0.249 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.641086e-01 0.249 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.641086e-01 0.249 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.641086e-01 0.249 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.641086e-01 0.249 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.641086e-01 0.249 0 0
PLC beta mediated events R-HSA-112043 5.742229e-01 0.241 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.745267e-01 0.241 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.745267e-01 0.241 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.746907e-01 0.241 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.771706e-01 0.239 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.790968e-01 0.237 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.790968e-01 0.237 0 0
Growth hormone receptor signaling R-HSA-982772 5.790968e-01 0.237 0 0
Erythropoietin activates RAS R-HSA-9027284 5.864155e-01 0.232 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.864155e-01 0.232 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.864155e-01 0.232 0 0
Formation of the anterior neural plate R-HSA-9823739 5.864155e-01 0.232 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.896385e-01 0.229 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.956876e-01 0.225 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.016362e-01 0.221 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.061419e-01 0.217 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.070946e-01 0.217 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.070946e-01 0.217 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.070946e-01 0.217 0 0
MET Receptor Activation R-HSA-6806942 6.070946e-01 0.217 0 0
Abacavir transmembrane transport R-HSA-2161517 6.070946e-01 0.217 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.070946e-01 0.217 0 0
VLDL assembly R-HSA-8866423 6.070946e-01 0.217 0 0
HDL clearance R-HSA-8964011 6.070946e-01 0.217 0 0
TBC/RABGAPs R-HSA-8854214 6.095447e-01 0.215 0 0
Prolonged ERK activation events R-HSA-169893 6.141896e-01 0.212 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.141896e-01 0.212 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.141896e-01 0.212 0 0
Gap junction assembly R-HSA-190861 6.149095e-01 0.211 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.149095e-01 0.211 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.149095e-01 0.211 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.149095e-01 0.211 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.183779e-01 0.209 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.220318e-01 0.206 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.224740e-01 0.206 0 0
Formation of the nephric duct R-HSA-9830364 6.238458e-01 0.205 0 0
Developmental Cell Lineages R-HSA-9734767 6.258387e-01 0.204 0 0
Netrin-1 signaling R-HSA-373752 6.264126e-01 0.203 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.293912e-01 0.201 0 0
Mitochondrial protein degradation R-HSA-9837999 6.371529e-01 0.196 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.394570e-01 0.194 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.396541e-01 0.194 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.405104e-01 0.193 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.405104e-01 0.193 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.405104e-01 0.193 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.405104e-01 0.193 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.458438e-01 0.190 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.458438e-01 0.190 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.458438e-01 0.190 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.458438e-01 0.190 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.458438e-01 0.190 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.458438e-01 0.190 0 0
Disinhibition of SNARE formation R-HSA-114516 6.458438e-01 0.190 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.458438e-01 0.190 0 0
LDL remodeling R-HSA-8964041 6.458438e-01 0.190 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.458438e-01 0.190 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.458438e-01 0.190 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.458438e-01 0.190 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.458438e-01 0.190 0 0
RET signaling R-HSA-8853659 6.516012e-01 0.186 0 0
Signaling by FGFR1 R-HSA-5654736 6.516128e-01 0.186 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.516147e-01 0.186 0 0
RSV-host interactions R-HSA-9833110 6.574324e-01 0.182 0 0
Gastrulation R-HSA-9758941 6.588646e-01 0.181 0 0
G-protein mediated events R-HSA-112040 6.599086e-01 0.181 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.599086e-01 0.181 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.652208e-01 0.177 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.652208e-01 0.177 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.652208e-01 0.177 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.653944e-01 0.177 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.653944e-01 0.177 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.653944e-01 0.177 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.653944e-01 0.177 0 0
Specification of primordial germ cells R-HSA-9827857 6.653944e-01 0.177 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.653944e-01 0.177 0 0
Synthesis of PA R-HSA-1483166 6.660324e-01 0.177 0 0
G alpha (12/13) signalling events R-HSA-416482 6.677620e-01 0.175 0 0
tRNA processing R-HSA-72306 6.739336e-01 0.171 0 0
Type I hemidesmosome assembly R-HSA-446107 6.807735e-01 0.167 0 0
RSK activation R-HSA-444257 6.807735e-01 0.167 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.807735e-01 0.167 0 0
phospho-PLA2 pathway R-HSA-111995 6.807735e-01 0.167 0 0
MET receptor recycling R-HSA-8875656 6.807735e-01 0.167 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.807735e-01 0.167 0 0
Co-stimulation by ICOS R-HSA-9927354 6.807735e-01 0.167 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.807735e-01 0.167 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.807735e-01 0.167 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.807735e-01 0.167 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.807735e-01 0.167 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.807735e-01 0.167 0 0
Sodium/Proton exchangers R-HSA-425986 6.807735e-01 0.167 0 0
Interleukin-23 signaling R-HSA-9020933 6.807735e-01 0.167 0 0
Infectious disease R-HSA-5663205 6.845189e-01 0.165 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.846254e-01 0.165 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.846254e-01 0.165 0 0
Insulin receptor recycling R-HSA-77387 6.846254e-01 0.165 0 0
Neddylation R-HSA-8951664 6.846533e-01 0.165 0 0
Interferon alpha/beta signaling R-HSA-909733 6.857464e-01 0.164 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.888690e-01 0.162 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.888690e-01 0.162 0 0
Mismatch Repair R-HSA-5358508 6.888690e-01 0.162 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.888690e-01 0.162 0 0
Polo-like kinase mediated events R-HSA-156711 6.888690e-01 0.162 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.888690e-01 0.162 0 0
Apoptotic factor-mediated response R-HSA-111471 6.888690e-01 0.162 0 0
Nephron development R-HSA-9831926 6.888690e-01 0.162 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.888690e-01 0.162 0 0
Intraflagellar transport R-HSA-5620924 6.893111e-01 0.162 0 0
Signaling by FGFR2 R-HSA-5654738 6.919656e-01 0.160 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.940792e-01 0.159 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.021030e-01 0.154 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.021030e-01 0.154 0 0
mRNA Capping R-HSA-72086 7.031768e-01 0.153 0 0
FOXO-mediated transcription R-HSA-9614085 7.035735e-01 0.153 0 0
Post-translational protein modification R-HSA-597592 7.051810e-01 0.152 0 0
tRNA Aminoacylation R-HSA-379724 7.069742e-01 0.151 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.109701e-01 0.148 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.109701e-01 0.148 0 0
Specification of the neural plate border R-HSA-9834899 7.109701e-01 0.148 0 0
The NLRP3 inflammasome R-HSA-844456 7.109701e-01 0.148 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.109701e-01 0.148 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.122600e-01 0.147 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.122600e-01 0.147 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.122600e-01 0.147 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.122600e-01 0.147 0 0
mRNA Editing R-HSA-75072 7.122600e-01 0.147 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.122600e-01 0.147 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.122600e-01 0.147 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.122600e-01 0.147 0 0
Interleukin-1 processing R-HSA-448706 7.122600e-01 0.147 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.122600e-01 0.147 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.177103e-01 0.144 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.177103e-01 0.144 0 0
Diseases of Immune System R-HSA-5260271 7.177103e-01 0.144 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.177103e-01 0.144 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.198345e-01 0.143 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.208826e-01 0.142 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.227015e-01 0.141 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.239192e-01 0.140 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.240296e-01 0.140 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.298380e-01 0.137 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.317402e-01 0.136 0 0
Signaling by NODAL R-HSA-1181150 7.317402e-01 0.136 1 1
VxPx cargo-targeting to cilium R-HSA-5620916 7.317402e-01 0.136 0 0
Heme signaling R-HSA-9707616 7.322976e-01 0.135 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.373616e-01 0.132 0 0
Downstream signal transduction R-HSA-186763 7.377544e-01 0.132 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.406426e-01 0.130 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.406426e-01 0.130 0 0
Binding and entry of HIV virion R-HSA-173107 7.406426e-01 0.130 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.406426e-01 0.130 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.406426e-01 0.130 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.406426e-01 0.130 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.406426e-01 0.130 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.406426e-01 0.130 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.406426e-01 0.130 0 0
Interleukin-27 signaling R-HSA-9020956 7.406426e-01 0.130 0 0
Maturation of spike protein R-HSA-9683686 7.406426e-01 0.130 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.445915e-01 0.128 0 0
Intra-Golgi traffic R-HSA-6811438 7.470944e-01 0.127 0 0
Hemostasis R-HSA-109582 7.480178e-01 0.126 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.498725e-01 0.125 0 0
G-protein activation R-HSA-202040 7.512269e-01 0.124 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.512269e-01 0.124 0 0
ERK/MAPK targets R-HSA-198753 7.512269e-01 0.124 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.512269e-01 0.124 0 0
Opioid Signalling R-HSA-111885 7.526827e-01 0.123 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.538073e-01 0.123 0 0
Ion transport by P-type ATPases R-HSA-936837 7.560322e-01 0.121 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.608828e-01 0.119 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.643842e-01 0.117 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.662270e-01 0.116 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.662270e-01 0.116 0 0
vRNA Synthesis R-HSA-192814 7.662270e-01 0.116 0 0
Chylomicron assembly R-HSA-8963888 7.662270e-01 0.116 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.662270e-01 0.116 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.662270e-01 0.116 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.662270e-01 0.116 0 0
Glutathione synthesis and recycling R-HSA-174403 7.694811e-01 0.114 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.694811e-01 0.114 0 0
Serine metabolism R-HSA-977347 7.694811e-01 0.114 0 0
Ribavirin ADME R-HSA-9755088 7.694811e-01 0.114 0 0
Innate Immune System R-HSA-168249 7.742594e-01 0.111 0 0
Metabolism of proteins R-HSA-392499 7.863901e-01 0.104 0 0
FGFR2 alternative splicing R-HSA-6803529 7.865563e-01 0.104 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.865563e-01 0.104 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.865563e-01 0.104 0 0
Proteasome assembly R-HSA-9907900 7.866960e-01 0.104 0 0
DAP12 interactions R-HSA-2172127 7.866960e-01 0.104 0 0
Amine ligand-binding receptors R-HSA-375280 7.866960e-01 0.104 0 0
Integrin cell surface interactions R-HSA-216083 7.869558e-01 0.104 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.892890e-01 0.103 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.892890e-01 0.103 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.892890e-01 0.103 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.892890e-01 0.103 0 0
Plasmalogen biosynthesis R-HSA-75896 7.892890e-01 0.103 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.892890e-01 0.103 0 0
Sodium/Calcium exchangers R-HSA-425561 7.892890e-01 0.103 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.892890e-01 0.103 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.972434e-01 0.098 0 0
eNOS activation R-HSA-203615 7.972434e-01 0.098 0 0
Transcription of the HIV genome R-HSA-167172 7.987945e-01 0.098 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.025074e-01 0.096 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.057023e-01 0.094 0 0
MET activates RAS signaling R-HSA-8851805 8.100771e-01 0.091 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.100771e-01 0.091 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.100771e-01 0.091 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.100771e-01 0.091 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.100771e-01 0.091 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.100771e-01 0.091 0 0
Regulation of IFNG signaling R-HSA-877312 8.100771e-01 0.091 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.100771e-01 0.091 0 0
Interleukin-35 Signalling R-HSA-8984722 8.100771e-01 0.091 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.100771e-01 0.091 0 0
OAS antiviral response R-HSA-8983711 8.100771e-01 0.091 0 0
Signalling to ERKs R-HSA-187687 8.102217e-01 0.091 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.102217e-01 0.091 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.133301e-01 0.090 0 0
Signaling by NTRKs R-HSA-166520 8.149625e-01 0.089 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.173901e-01 0.088 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.173901e-01 0.088 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.235217e-01 0.084 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.288154e-01 0.082 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.288154e-01 0.082 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.288154e-01 0.082 0 0
Frs2-mediated activation R-HSA-170968 8.288154e-01 0.082 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.288154e-01 0.082 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.288154e-01 0.082 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.288154e-01 0.082 0 0
Interleukin-6 signaling R-HSA-1059683 8.288154e-01 0.082 0 0
Tight junction interactions R-HSA-420029 8.312597e-01 0.080 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.312597e-01 0.080 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.312597e-01 0.080 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.312597e-01 0.080 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.314114e-01 0.080 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.316054e-01 0.080 0 0
NGF-stimulated transcription R-HSA-9031628 8.316054e-01 0.080 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.326604e-01 0.080 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.330486e-01 0.079 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.395634e-01 0.076 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.416956e-01 0.075 0 0
MET activates PTK2 signaling R-HSA-8874081 8.441714e-01 0.074 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.450033e-01 0.073 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.457060e-01 0.073 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.457060e-01 0.073 0 0
cGMP effects R-HSA-418457 8.457060e-01 0.073 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.457060e-01 0.073 0 0
Hydrolysis of LPC R-HSA-1483115 8.457060e-01 0.073 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.457060e-01 0.073 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.457060e-01 0.073 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.457060e-01 0.073 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.457060e-01 0.073 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.503251e-01 0.070 0 0
Signaling by PDGF R-HSA-186797 8.503251e-01 0.070 0 0
PI3K Cascade R-HSA-109704 8.509320e-01 0.070 0 0
Signaling by FGFR in disease R-HSA-1226099 8.517566e-01 0.070 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.553006e-01 0.068 0 0
Pentose phosphate pathway R-HSA-71336 8.553006e-01 0.068 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.564653e-01 0.067 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.609309e-01 0.065 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.609309e-01 0.065 0 0
Signaling by Activin R-HSA-1502540 8.609309e-01 0.065 1 1
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.609309e-01 0.065 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.609309e-01 0.065 0 0
Other semaphorin interactions R-HSA-416700 8.609309e-01 0.065 0 0
p38MAPK events R-HSA-171007 8.609309e-01 0.065 0 0
DNA Damage Reversal R-HSA-73942 8.609309e-01 0.065 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.649945e-01 0.063 0 0
Interleukin-2 family signaling R-HSA-451927 8.649945e-01 0.063 0 0
IGF1R signaling cascade R-HSA-2428924 8.664132e-01 0.062 0 0
Ion channel transport R-HSA-983712 8.669187e-01 0.062 0 0
Telomere Extension By Telomerase R-HSA-171319 8.673351e-01 0.062 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.673351e-01 0.062 0 0
Prednisone ADME R-HSA-9757110 8.673351e-01 0.062 0 0
Inflammasomes R-HSA-622312 8.673351e-01 0.062 0 0
Pyroptosis R-HSA-5620971 8.673351e-01 0.062 0 0
Stimuli-sensing channels R-HSA-2672351 8.733672e-01 0.059 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.738951e-01 0.059 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.746543e-01 0.058 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.746543e-01 0.058 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.746543e-01 0.058 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.746543e-01 0.058 0 0
Activation of SMO R-HSA-5635838 8.746543e-01 0.058 0 0
Fructose catabolism R-HSA-70350 8.746543e-01 0.058 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.746543e-01 0.058 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.746543e-01 0.058 0 0
Attachment and Entry R-HSA-9678110 8.746543e-01 0.058 0 0
Virus Assembly and Release R-HSA-168268 8.746543e-01 0.058 0 0
Signaling by FGFR R-HSA-190236 8.766145e-01 0.057 0 0
DARPP-32 events R-HSA-180024 8.776909e-01 0.057 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.810184e-01 0.055 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.826791e-01 0.054 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.870242e-01 0.052 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.870242e-01 0.052 0 0
Passive transport by Aquaporins R-HSA-432047 8.870242e-01 0.052 0 0
Fibronectin matrix formation R-HSA-1566977 8.870242e-01 0.052 0 0
Coenzyme A biosynthesis R-HSA-196783 8.870242e-01 0.052 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.870242e-01 0.052 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.870242e-01 0.052 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.870242e-01 0.052 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.870242e-01 0.052 0 0
Interleukin-37 signaling R-HSA-9008059 8.872957e-01 0.052 0 0
Kidney development R-HSA-9830369 8.877951e-01 0.052 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.961967e-01 0.048 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.961967e-01 0.048 0 0
NRAGE signals death through JNK R-HSA-193648 8.979690e-01 0.047 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.979690e-01 0.047 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.981740e-01 0.047 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.981740e-01 0.047 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.981740e-01 0.047 0 0
Choline catabolism R-HSA-6798163 8.981740e-01 0.047 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.981740e-01 0.047 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.014306e-01 0.045 0 0
Signaling by Insulin receptor R-HSA-74752 9.033384e-01 0.044 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.033384e-01 0.044 0 0
IRS-mediated signalling R-HSA-112399 9.043905e-01 0.044 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.082240e-01 0.042 0 0
PKA activation R-HSA-163615 9.082240e-01 0.042 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.082240e-01 0.042 0 0
Platelet sensitization by LDL R-HSA-432142 9.082240e-01 0.042 0 0
Tie2 Signaling R-HSA-210993 9.082240e-01 0.042 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.083432e-01 0.042 0 0
SLC transporter disorders R-HSA-5619102 9.101067e-01 0.041 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.166918e-01 0.038 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.169046e-01 0.038 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.172826e-01 0.037 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.172826e-01 0.037 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.172826e-01 0.037 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.172826e-01 0.037 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.172826e-01 0.037 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.172826e-01 0.037 0 0
Diseases of hemostasis R-HSA-9671793 9.172826e-01 0.037 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.172826e-01 0.037 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.181670e-01 0.037 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.181670e-01 0.037 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.191201e-01 0.037 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.191201e-01 0.037 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.191201e-01 0.037 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.191201e-01 0.037 0 0
Heme degradation R-HSA-189483 9.191201e-01 0.037 0 0
Metabolism of polyamines R-HSA-351202 9.215564e-01 0.035 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.218556e-01 0.035 0 0
Interferon gamma signaling R-HSA-877300 9.221709e-01 0.035 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.239664e-01 0.034 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.254476e-01 0.034 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.254476e-01 0.034 0 0
Creatine metabolism R-HSA-71288 9.254476e-01 0.034 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.254476e-01 0.034 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.254476e-01 0.034 0 0
Signal amplification R-HSA-392518 9.256384e-01 0.034 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.279335e-01 0.032 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.316584e-01 0.031 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.328071e-01 0.030 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.328071e-01 0.030 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.328071e-01 0.030 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.328071e-01 0.030 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.328071e-01 0.030 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.328071e-01 0.030 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.328071e-01 0.030 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.328071e-01 0.030 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.328071e-01 0.030 0 0
Signalling to RAS R-HSA-167044 9.328071e-01 0.030 0 0
Leishmania phagocytosis R-HSA-9664417 9.329606e-01 0.030 0 0
Parasite infection R-HSA-9664407 9.329606e-01 0.030 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.329606e-01 0.030 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.344500e-01 0.029 0 0
RUNX2 regulates bone development R-HSA-8941326 9.372151e-01 0.028 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.372151e-01 0.028 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.389786e-01 0.027 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.391405e-01 0.027 0 0
Azathioprine ADME R-HSA-9748787 9.391762e-01 0.027 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.394404e-01 0.027 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.394404e-01 0.027 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.394404e-01 0.027 0 0
Attachment and Entry R-HSA-9694614 9.394404e-01 0.027 0 0
Insulin receptor signalling cascade R-HSA-74751 9.401283e-01 0.027 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.423411e-01 0.026 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.428864e-01 0.026 0 0
Neurotransmitter release cycle R-HSA-112310 9.431028e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.454193e-01 0.024 0 0
LDL clearance R-HSA-8964038 9.454193e-01 0.024 0 0
Fructose metabolism R-HSA-5652084 9.454193e-01 0.024 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.454193e-01 0.024 0 0
MET promotes cell motility R-HSA-8875878 9.470673e-01 0.024 0 0
Elastic fibre formation R-HSA-1566948 9.470673e-01 0.024 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.470673e-01 0.024 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.508082e-01 0.022 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.508082e-01 0.022 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.508082e-01 0.022 0 0
Formation of the ureteric bud R-HSA-9830674 9.508082e-01 0.022 0 0
Syndecan interactions R-HSA-3000170 9.508082e-01 0.022 0 0
Biosynthesis of maresins R-HSA-9018682 9.508082e-01 0.022 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.514228e-01 0.022 0 0
Tryptophan catabolism R-HSA-71240 9.554345e-01 0.020 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.556653e-01 0.020 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.556653e-01 0.020 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.556653e-01 0.020 0 0
Complex III assembly R-HSA-9865881 9.556653e-01 0.020 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.556653e-01 0.020 0 0
Interleukin-6 family signaling R-HSA-6783589 9.556653e-01 0.020 0 0
G alpha (z) signalling events R-HSA-418597 9.584136e-01 0.018 0 0
Paracetamol ADME R-HSA-9753281 9.584136e-01 0.018 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.591280e-01 0.018 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.600431e-01 0.018 0 0
G protein gated Potassium channels R-HSA-1296059 9.600431e-01 0.018 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.600431e-01 0.018 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.600431e-01 0.018 0 0
Hyaluronan degradation R-HSA-2160916 9.600431e-01 0.018 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.600431e-01 0.018 0 0
Platelet homeostasis R-HSA-418346 9.605613e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.605663e-01 0.017 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.625269e-01 0.017 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.639889e-01 0.016 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.639889e-01 0.016 0 0
TRP channels R-HSA-3295583 9.639889e-01 0.016 0 0
Abacavir ADME R-HSA-2161522 9.639889e-01 0.016 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.639889e-01 0.016 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.639889e-01 0.016 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.656533e-01 0.015 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.656533e-01 0.015 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.670439e-01 0.015 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.675452e-01 0.014 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.675452e-01 0.014 0 0
Triglyceride biosynthesis R-HSA-75109 9.675452e-01 0.014 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.675452e-01 0.014 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.675452e-01 0.014 0 0
Adipogenesis R-HSA-9843745 9.677814e-01 0.014 0 0
Cardiac conduction R-HSA-5576891 9.677814e-01 0.014 0 0
Disease R-HSA-1643685 9.680692e-01 0.014 0 0
Aspirin ADME R-HSA-9749641 9.681585e-01 0.014 0 0
Surfactant metabolism R-HSA-5683826 9.711700e-01 0.013 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.735974e-01 0.012 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.736394e-01 0.012 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.736394e-01 0.012 0 0
Glucagon-type ligand receptors R-HSA-420092 9.736394e-01 0.012 0 0
Transmission across Chemical Synapses R-HSA-112315 9.750757e-01 0.011 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.758268e-01 0.011 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.759454e-01 0.011 0 0
PI Metabolism R-HSA-1483255 9.762262e-01 0.010 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.762431e-01 0.010 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.762431e-01 0.010 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.778565e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.778735e-01 0.010 0 0
Cargo concentration in the ER R-HSA-5694530 9.785898e-01 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.797554e-01 0.009 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.807048e-01 0.008 0 0
DAG1 glycosylations R-HSA-8931838 9.807048e-01 0.008 0 0
Peptide hormone metabolism R-HSA-2980736 9.821367e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.826110e-01 0.008 0 0
Neuronal System R-HSA-112316 9.826489e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.830558e-01 0.007 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.843290e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.843290e-01 0.007 0 0
The phototransduction cascade R-HSA-2514856 9.845051e-01 0.007 0 0
Complex IV assembly R-HSA-9864848 9.845051e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.851361e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.858773e-01 0.006 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.858773e-01 0.006 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.858773e-01 0.006 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.861388e-01 0.006 0 0
Nucleotide biosynthesis R-HSA-8956320 9.870507e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.872728e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.872728e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.873678e-01 0.006 0 0
Regulation of insulin secretion R-HSA-422356 9.879736e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.883592e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.885290e-01 0.005 0 0
Triglyceride catabolism R-HSA-163560 9.885304e-01 0.005 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.885304e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.896638e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.896638e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.896638e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.896638e-01 0.005 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.909040e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.909780e-01 0.004 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.916261e-01 0.004 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.924356e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.924780e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.924780e-01 0.003 0 0
Glutathione conjugation R-HSA-156590 9.931335e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.931833e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.931833e-01 0.003 0 0
Aquaporin-mediated transport R-HSA-445717 9.937330e-01 0.003 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.938571e-01 0.003 0 0
HIV Transcription Initiation R-HSA-167161 9.938571e-01 0.003 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.938571e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.943603e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.944643e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.944643e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.948316e-01 0.002 0 0
Peptide ligand-binding receptors R-HSA-375276 9.948491e-01 0.002 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.950116e-01 0.002 0 0
Methylation R-HSA-156581 9.955048e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.955048e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.956661e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.958593e-01 0.002 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.959493e-01 0.002 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.959493e-01 0.002 0 0
Bacterial Infection Pathways R-HSA-9824439 9.961343e-01 0.002 0 0
GPER1 signaling R-HSA-9634597 9.970360e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.970360e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.973291e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.975079e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.975079e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.975933e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.978313e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.980760e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.980760e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.981884e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.984410e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.984664e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.987038e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.989093e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.989171e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.989171e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.989543e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.989686e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.991076e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.991508e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.991508e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.991508e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.992349e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.992514e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.993719e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993788e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.993918e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994403e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.994403e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994869e-01 0.000 0 0
Integration of energy metabolism R-HSA-163685 9.995786e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995906e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997123e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997302e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997462e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997462e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997570e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997889e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998223e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998233e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998541e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998675e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998755e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998906e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999049e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999098e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999146e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999305e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999524e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999541e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999665e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999821e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999936e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999942e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999952e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999956e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999965e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999973e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999984e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999985e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999989e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999993e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999994e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
G alpha (s) signalling events R-HSA-418555 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways