AMPKA2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00418 S366 SIGNOR|ELM|iPTMNet|EPSD EEF2K AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS
O00418 S398 SIGNOR|ELM|iPTMNet|EPSD|PSP EEF2K ENSGDENMSDVTFDsLPSsPsSATPHSQKLDHLHWPVFSDL
O00418 S78 SIGNOR|ELM|iPTMNet|EPSD EEF2K KYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKHMPDP
O00763 S222 SIGNOR|ELM|iPTMNet|EPSD ACACB ACC2 ACCB EAYLTTGEAETRVPTMRPSMsGLHLVKRGREHKKLDLHRDF
O14920 S177 SIGNOR|EPSD|PSP IKBKB IKKB EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14920 S181 SIGNOR|EPSD|PSP IKBKB IKKB IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O14929 S190 SIGNOR HAT1 KAT1 GFREYHERLQTFLMWFIETAsFIDVDDERWHYFLVFEKYNK
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43524 S399 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A NDGLTENLMDDLLDNITLPPsQPSPTGGLMQRSSsFPYTTK
O43524 S413 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A NITLPPsQPSPTGGLMQRSSsFPYTTKGsGLGsPtssFNst
O43524 S555 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A HHQHQTQGALGGSRALsNsVsNMGLSESSSLGSAKHQQQsP
O43524 S588 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A AKHQQQsPVSQSMQTLSDSLsGSSLYSTSANLPVMGHEKFP
O43524 S626 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A KFPSDLDLDMFNGSLECDMEsIIRSELMDADGLDFNFDsLI
O43524 T179 SIGNOR|EPSD|PSP FOXO3 FKHRL1 FOXO3A NLSYADLITRAIESSPDKRLtLSQIYEWMVRCVPYFKDKGD
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60825 S466 SIGNOR|ELM|iPTMNet|EPSD PFKFB2 RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O75128 S1171 Sugiyama COBL KIAA0633 SALLAAIRGHSGTCSLRKVAsSAsEELQSFRDAALSAQGSE
O75128 S1174 Sugiyama COBL KIAA0633 LAAIRGHSGTCSLRKVAsSAsEELQSFRDAALSAQGSESPL
O75151 S655 PSP PHF2 CENP-35 KIAA0662 FSFsFsNKKLLGSKALRPPtsPGVFGALQNFKEDKPKPVRD
O75385 S317 SIGNOR ULK1 KIAA0722 ssGSGSSSSSSSTSHLASPPsLGEMQQLQKTLAsPADTAGF
O75385 S556 SIGNOR ULK1 KIAA0722 PGssAPEHsPRTSGLGCRLHsAPNLSDLHVVRPKLPKPPTD
O75385 S638 SIGNOR ULK1 KIAA0722 PPILGsPtKAVPSFDFPKtPssQNLLALLARQGVVMTPPRN
O95278 S25 SIGNOR EPM2A FGVVVPPAVAGARPELLVVGsRPELGRWEPRGAVRLRPAGT
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338 S105 Sugiyama LDHA PIG19 VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S319 Sugiyama LDHA PIG19 GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04049 S259 SIGNOR RAF1 RAF tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04049 S621 SIGNOR RAF1 RAF QILssIELLQHsLPKINRsAsEPsLHRAAHtEDINACtLtt
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083 T172 Sugiyama ANXA1 ANX1 LPC1 INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S122 SIGNOR GAPDH GAPD CDABP0047 OK/SW-cl.12 FttMEKAGAHLQGGAKRVIIsAPsADAPMFVMGVNHEKYDN
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637 S15 SIGNOR TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05091 T356 SIGNOR ALDH2 ALDM VERSVARAKSRVVGNPFDSKtEQGPQVDETQFKKILGYINT
P05187 S114 Sugiyama ALPP PLAP DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05549 S219 EPSD|PSP TFAP2A AP2TF TFAP2 NLFGGVVNPNEVFCSVPGRLsLLsstsKYKVTVAEVQRRLs
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06400 S811 SIGNOR RB1 KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P07195 S106 Sugiyama LDHB VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07602 S29 Sugiyama PSAP GLBA SAP1 SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07711 S329 Sugiyama CTSL CTSL1 GGyVKMAKDRRNHCGIAsAAsyPtV________________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07954 S75 SIGNOR FH DtFGELKVPNDKYYGAQTVRsTMNFKIGGVTERMPtPVIKA
P08151 S102 SIGNOR|EPSD|PSP GLI1 GLI ALsISPLSDASLDLQTVIRTsPSSLVAFINSRCTsPGGSYG
P08151 S408 SIGNOR|EPSD|PSP GLI1 GLI GPDAHVtKRHRGDGPLPRAPsISTVEPKREREGGPIREESR
P08151 T1074 SIGNOR|EPSD|PSP GLI1 GLI DEPQGLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRS
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T94 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSGtKAFM
P08559 S295 SIGNOR|PSP PDHA1 PHE1A SGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsD
P08559 S314 SIGNOR|PSP PDHA1 PHE1A MsDPGVsyRtREEIQEVRsKsDPIMLLKDRMVNSNLAsVEE
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09874 S177 EPSD|PSP PARP1 ADPRT PPOL WYHPGCFVKNREELGFRPEYsAsQLKGFsLLAtEDKEALKK
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10636 S214 SIGNOR MAPT MAPTL MTBT1 TAU GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P10636 S396 SIGNOR MAPT MAPTL MTBT1 TAU ARMVSKSKDGtGSDDKKAKTsTRSsAKtLKNRPCLsPKHPT
P10636 S420 SIGNOR MAPT MAPTL MTBT1 TAU sAKtLKNRPCLsPKHPTPGSsDPLIQPssPAVCPEPPssPK
P10696 S111 Sugiyama ALPG ALPPL ALPPL2 DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11532 S3624 Sugiyama DMD AKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEED
P11586 S318 Sugiyama MTHFD1 MTHFC MTHFD FKPGKWMIQYNNLNLKTPVPsDIDIsRSCKPKPIGKLAREI
P11908 S180 SIGNOR PRPS2 AEWKNCIIVSPDAGGAKRVTsIADRLNVEFALIHKERKKAN
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13569 S737 SIGNOR CFTR ABCC7 TPLQMNGIEEDSDEPLERRLsLVPDSEQGEAILPRIsVIST
P13569 S768 SIGNOR CFTR ABCC7 ILPRIsVISTGPTLQARRRQsVLNLMTHSVNQGQNIHRKTT
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13797 S540 Sugiyama PLS3 NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798 S187 Sugiyama APEH D3F15S2 D3S48E DNF15S2 EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13807 S8 SIGNOR GYS1 GYS _____________MPLNRTLsMssLPGLEDWEDEFDLENAV
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S139 Sugiyama NELFE RD RDBP DLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGAG
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18669 S152 Sugiyama PGAM1 PGAMA CDABP0006 FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P22460 S559 SIGNOR KCNA5 QGTQSQGPGLDRGVQRKVSGsRGSFCKAGGTLENADSARRG
P22460 S592 SIGNOR KCNA5 NADSARRGSCPLEKCNVKAKsNVDLRRSLYALCLDTSRETD
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25398 S107 Sugiyama RPS12 EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25705 S76 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P26358 S714 SIGNOR DNMT1 AIM CXXC9 DNMT MAMKEADDDEEVDDNIPEMPsPKKMHQGKKKKQNKNRIsWV
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28562 S334 SIGNOR|EPSD|PSP DUSP1 CL100 MKP1 PTPN10 VH1 APHCSAEAGsPAMAVLDRGTsTTTVFNFPVSIPVHSTNSAL
P29401 S105 Sugiyama TKT VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29474 S1177 SIGNOR NOS3 EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30260 S379 SIGNOR|EPSD|PSP CDC27 ANAPC3 D0S1430E D17S978E tPQVLsPtItsPPNALPRRSsRLFtsDssTTKENsKKLKMK
P30622 S195 Sugiyama CLIP1 CYLN1 RSN AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32929 S346 SIGNOR CTH EIFLKNLKLFTLAESLGGFEsLAELPAIMtHASVLKNDRDV
P32929 T355 SIGNOR CTH FTLAESLGGFEsLAELPAIMtHASVLKNDRDVLGISDtLIR
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35568 S794 ELM IRS1 tQRPGEPEEGARHQHLRLSTsSGRLLYAATADDSSSStSSD
P35790 S279 SIGNOR|PSP CHKA CHK CKI EVLRIKFTEESRIKKLHKLLsYNLPLELENLRSLLESTPSP
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36956 S396 SIGNOR SREBF1 BHLHD1 SREBP1 SNQKLKQENLSLRTAVHKsKsLKDLVSACGSGGNTDVLMEG
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41235 S303 SIGNOR HNF4A HNF4 NR2A1 TCF14 DNEyAyLKAIIFFDPDAKGLsDPGKIKRLRsQVQVsLEDYI
P41235 S313 SIGNOR|ELM|iPTMNet|EPSD HNF4A HNF4 NR2A1 TCF14 IFFDPDAKGLsDPGKIKRLRsQVQVsLEDYINDRQYDSRGR
P42345 S1261 SIGNOR MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 QGDALASGPVETGPMKKLHVstINLQKAWGAARRVSKDDWL
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46013 S651 Sugiyama MKI67 ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46937 S382 Sugiyama YAP1 YAP65 QNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstDsGL
P46937 S94 SIGNOR YAP1 YAP65 NPKtANVPQtVPMRLRKLPDsFFKPPEPKsHsRQAstDAGt
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48764 S555 SIGNOR SLC9A3 NHE3 FHELNLKDAISYVAEGERRGsLAFIRsPsTDNVVNVDFTPR
P48764 S563 SIGNOR SLC9A3 NHE3 AISYVAEGERRGsLAFIRsPsTDNVVNVDFTPRSSTVEASV
P49116 S351 SIGNOR NR2C2 TAK1 TR4 LADGIDTSGGGSIHVISRDQstPIIEVEGPLLSDTHVTFKL
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49674 S389 SIGNOR CSNK1E RVDRERKVSMRLHRGAPANVsssDLTGRQEVSRIPAsQtsV
P49815 S1387 SIGNOR TSC2 TSC4 GGRPsVDLsFQPsQPLsKssssPELQtLQDILGDPGDKADV
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50552 S322 SIGNOR VASP QSEsVRRPWEKNstTLPRMKssssVttsEtQPCtPsSSDyS
P50552 T278 SIGNOR VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P50552 T327 Sugiyama VASP RRPWEKNstTLPRMKssssVttsEtQPCtPsSSDySDLQRV
P52292 S105 SIGNOR|ELM KPNA2 RCH1 SRP1 INssNVENQLQATQAARKLLsREKQPPIDNIIRAGLIPKFV
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52943 S115 Sugiyama CRIP2 CRP2 AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54646 S377 Sugiyama PRKAA2 AMPK AMPK2 MHIPPGLKPHPERMPPLIADsPKARCPLDALNTTKPKSLAV
P54646 S481 Sugiyama PRKAA2 AMPK AMPK2 DNRSYLLDFKSIDDEVVEQRsGsstPQRSCsAAGLHRPRss
P54646 S483 Sugiyama PRKAA2 AMPK AMPK2 RSYLLDFKSIDDEVVEQRsGsstPQRSCsAAGLHRPRssFD
P54646 S484 Sugiyama PRKAA2 AMPK AMPK2 SYLLDFKSIDDEVVEQRsGsstPQRSCsAAGLHRPRssFDs
P54646 S54 Sugiyama PRKAA2 AMPK AMPK2 EHQLTGHKVAVKILNRQKIRsLDVVGKIKREIQNLKLFRHP
P54646 T172 ELM|PSP PRKAA2 AMPK AMPK2 NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P54646 T485 Sugiyama PRKAA2 AMPK AMPK2 YLLDFKSIDDEVVEQRsGsstPQRSCsAAGLHRPRssFDst
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54840 S8 SIGNOR GYS2 _____________MLRGRSLsVTSLGGLPQWEVEELPVEEL
P55011 S77 SIGNOR SLC12A2 NKCC1 RDEGPAAAGDGLGRPLGPtPsQsRFQVDLVSENAGRAAAAA
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060 S931 Sugiyama CSE1L CAS XPO2 KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55212 S257 ELM CASP6 MCH2 GKYGSSLEFTELLTLVNRKVsQRRVDFCKDPSAIGKKQVPC
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60891 S180 SIGNOR PRPS1 SEWRNCTIVSPDAGGAKRVTsIADRLNVDFALIHKERKKAN
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00587 S192 Sugiyama CDC42EP1 BORG5 CEP1 MSE55 PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q05469 S855 SIGNOR|ELM LIPE SGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKNLT
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09472 S89 ELM EP300 P300 GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q12888 S1317 PSP TP53BP1 GDLGDISSFSSKAssLHRtssGtsLsAMHSSGssGKGAGPL
Q13085 S1201 ELM ACACA ACAC ACC1 ACCA QFMLPTSHPNRGNIPTLNRMsFssNLNHyGMtHVAsVsDVL
Q13085 S80 SIGNOR|ELM|EPSD|PSP ACACA ACAC ACC1 ACCA sDLGISSLQDGLALHIRssMsGLHLVKQGRDRKKIDSQRDF
Q13098 S483 Sugiyama GPS1 COPS1 CSN1 QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13131 S486 SIGNOR PRKAA1 AMPK1 DsRTYLLDFRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRs
Q13131 S65 Sugiyama PRKAA1 AMPK1 KHELTGHKVAVKILNRQKIRsLDVVGKIRREIQNLKLFRHP
Q13177 S20 SIGNOR|EPSD|PSP PAK2 _MsDNGELEDKPPAPPVRMsstIFsTGGKDPLsANHsLKPL
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13363 S158 SIGNOR CTBP1 CTBP NLYRRAtWLHQALREGTRVQsVEQIREVASGAARIRGETLG
Q13393 S505 SIGNOR|EPSD|PSP PLD1 GRWDDNEHRLTDVGsVKRVtsGPsLGSLPPAAMEsMEsLRL
Q13621 S122 SIGNOR SLC12A1 NKCC2 GHNtMDAVPKIEYYRNtGsIsGPKVNRPsLLEIHEQLAKNV
Q13625 S480 Sugiyama TP53BP2 ASPP2 BBP FDAVDQSNAPPSFGTLRKNQssEDILRDAQVANKNVAKVPP
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14157 S859 Sugiyama UBAP2L KIAA0144 NICE4 FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14524 T101 SIGNOR SCN5A EDLDPFYSTQKTFIVLNKGKtIFRFSATNALYVLSPFHPIR
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S85 Sugiyama PTGES3 P23 TEBP KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15293 S80 Sugiyama RCN1 RCN HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q15818 S91 Sugiyama NPTX1 TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16526 S280 SIGNOR CRY1 PHLL1 LSCRLFYFKLTDLYKKVKKNsSPPLSLYGQLLWREFFYTAA
Q16526 S71 SIGNOR CRY1 PHLL1 RWRFLLQCLEDLDANLRKLNsRLFVIRGQPADVFPRLFKEW
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S314 SIGNOR RBBP7 RBAP46 DKTVALWDLRNLKLKLHTFEsHKDEIFQVHWSPHNETILAS
Q16658 S237 Sugiyama FSCN1 FAN1 HSN SNL RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q16875 S461 SIGNOR|ELM PFKFB3 THRERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEE
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q53ET0 S170 SIGNOR CRTC2 TORC2 GNFPAEKGQLFRLPSALNRtssDsALHtsVMNPsPQDtYPG
Q53ET0 S171 SIGNOR CRTC2 TORC2 NFPAEKGQLFRLPSALNRtssDsALHtsVMNPsPQDtYPGP
Q5SYE7 S1495 Sugiyama NHSL1 C6orf63 KIAA1357 KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5T5Y3 S1398 Sugiyama CAMSAP1 sCSDsGTKCSSTPDNLSRtQsGssLsLAsAAttEPESVHSG
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6GYQ0 S797 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6N021 S99 SIGNOR TET2 KIAA1546 Nbla00191 TQESRGYSKCLQNGGIKRtVsEPsLSGLLQIKKLKQDQKAN
Q6TCH7 T32 SIGNOR PAQR3 IELGSYQYWPVLVPRGIRLYtYEQIPGSLKDNPYITDGYRA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z3C6 S761 SIGNOR ATG9A APG9L1 sAPDEGGEGARAPQSIPRsAsYPCAAPRPGAPETTALHGGF
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z460 S545 Sugiyama CLASP1 KIAA0622 MAST1 yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86TI0 S237 SIGNOR|PSP TBC1D1 KIAA1108 PHAAPTGSQEPVRRPMRKsFsQPGLRSLAFRKELQDGGLRs
Q86TI0 T596 PSP TBC1D1 KIAA1108 HLPEEPAPLsPQQAFRRRANtLsHFPIECQEPPQPARGsPG
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IY63 S793 SIGNOR AMOTL1 QQRSRKDAGKTDsssLRPARsVPsIAAATGtHsRQtsLtSS
Q8N122 S722 SIGNOR RPTOR KIAA1303 RAPTOR GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N122 S792 SIGNOR|PSP RPTOR KIAA1303 RAPTOR PENEEHILSFETIDKMRRAssYSSLNSLIGVSFNSVYTQIW
Q8N2F6 S45 SIGNOR|PSP ARMC10 SVH PSEC0198 YRLTRGRRRGDRELGIRssKsAGALEEGtsEGQLCGRSARP
Q8N806 S265 Sugiyama UBR7 C14orf130 KDDVREVKVEQNsEPCAGsssEsDLQtVFKNESLNAESKSG
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND76 S326 SIGNOR CCNY C10orf9 CBCP1 CFP1 SRLCEDKYKDLRRSARKRsAsADNLtLPRWsPAIIS_____
Q8NE86 S57 SIGNOR MCU C10orf42 CCDC109A LGVSRHRQQQHHRTVHQRIAsWQNLGAVYCSTVVPSDDVTV
Q8WUF5 S102 Sugiyama PPP1R13L IASPP NKIP1 PPP1R13BL RAI RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q8WUI4 S155 SIGNOR HDAC7 HDAC7A PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WUI4 S358 SIGNOR HDAC7 HDAC7A LMTTERLSGSGLHWPLSRtRsEPLPPSATAPPPPGPMQPRL
Q8WUI4 S405 Sugiyama HDAC7 HDAC7A VQVIKRSAKPSEKPRLRQIPsAEDLEtDGGGPGQVVDDGLE
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q92786 S79 SIGNOR|PSP PROX1 VQHADGEKSNVLRKLLKRANsYEDAMMPFPGATIISQLLKN
Q92819 T110 SIGNOR|EPSD|PSP HAS2 AAYQEDPDYLRKCLQSVKRLtYPGIKVVMVIDGNSEDDLYM
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96L92 S51 Sugiyama SNX27 KIAA0488 My014 AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q96P16 S285 Sugiyama RPRD1A P15RS YKRKLARVSLVRKELRSRIQsLPDLSRLPNVTGSHMHLPFA
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96PU5 S795 SIGNOR NEDD4L KIAA0439 NEDL3 FCIDEENFGQTYQVDLKPNGsEIMVTNENKREYIDLVIQWR
Q99961 S64 Sugiyama SH3GL1 CNSA1 SH3D2B SKAVTEVLARTIEyLQPNPAsRAKLTMLNTVSKIRGQVKNP
Q99962 S64 Sugiyama SH3GL2 CNSA2 SH3D2A SRAVMEIMTKTIEyLQPNPAsRAKLSMINTMsKIRGQEKGP
Q9BRK0 S150 PSP REEP2 C5orf19 SGC32445 ANAAVTAAAKGVLSEKLRSFsMQDLTLIRDEDALPLQRPDG
Q9BU19 S470 SIGNOR ZNF692 AREBP ZFP692 CEFCGKRFEKPDSVAAHRSKsHPALLLAPQESPSGPLEPCP
Q9BXM7 S228 EPSD|PSP PINK1 APGAPAFPLAIKMMWNISAGsSSEAILNTMSQELVPASRVA
Q9BXM7 S284 EPSD|PSP PINK1 GPKQLAPHPNIIRVLRAFTSsVPLLPGALVDYPDVLPSRLH
Q9BXM7 S495 EPSD|PSP PINK1 PESVPPDVRQLVRALLQREAsKRPSARVAANVLHLSLWGEH
Q9BZL4 S452 SIGNOR|EPSD|PSP PPP1R12C LENG3 MBS85 GPPERRTAEGAPGAGLQRsAsssWLEGTSTQAKELRLARIT
Q9GZY8 S155 SIGNOR MFF C2orf33 AD030 AD033 GL004 PPttPQNEEIRAVGRLKRERsMsENAVRQNGQLVRNDsLWH
Q9GZY8 S172 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 RERsMsENAVRQNGQLVRNDsLWHRsDsAPRNKISRFQAPI
Q9H0B6 S582 SIGNOR KLC2 KKLQGGtPQEPPNPRMKRAssLNFLNKsVEEPTQPGGTGLs
Q9H2X6 S121 SIGNOR|PSP HIPK2 TSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIENT
Q9H2X6 T1114 PSP HIPK2 AHLPTQPHLYTYTAPAALGStGtVAHLVASQGSARHTVQHT
Q9H2X6 T1116 SIGNOR HIPK2 LPTQPHLYTYTAPAALGStGtVAHLVASQGSARHTVQHTAY
Q9H2X6 T119 SIGNOR|PSP HIPK2 SSTSVTGQVLGGPHNLMRRstVsLLDtyQKCGLKRKSEEIE
Q9H3M7 S308 SIGNOR TXNIP VDUP1 VILDLPLVIGSRSGLSSRTSsMASRTSSEMSWVDLNIPDTP
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9H902 S152 PSP REEP1 C2orf23 SPG31 AAVMAASKGQGALSERLRSFsMQDLTTIRGDGAPAPSGPPP
Q9HCN8 S40 Sugiyama SDF2L1 UNQ1941/PRO4424 ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9NP71 S556 SIGNOR MLXIPL BHLHD14 MIO WBSCR14 KPEQALEPPLVSSTLLRSPGsPQETVPEFPCTFLPPTPAPT
Q9NQP4 S125 Sugiyama PFDN4 PFD4 VEsIQRVLADLKVQLYAKFGsNINLEADEs___________
Q9NR19 S659 SIGNOR ACSS2 ACAS2 IGPIAtPDYIQNAPGLPKTRsGKIMRRVLRKIAQNDHDLGD
Q9NRC8 T153 SIGNOR SIRT7 SIR2L7 RsVsAADLSEAEPTLTHMSItRLHEQKLVQHVVSQNCDGLH
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NSK0 S590 PSP KLC4 KNSL8 VRKLQGTEPRPSSSNMKRAAsLNyLNQPsAAPLQVSRGLsA
Q9NVU7 T552 Sugiyama SDAD1 NUC130 SMPMEERKAKAAAISTSRVLtQEDFQKIRMAQMRKELDAAP
Q9NYB9 S22 Sugiyama ABI2 ARGBPIA AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NYV6 S635 SIGNOR RRN3 TIFIA QNDTVIGItPSsFDtHFRsPsssVGsPPVLyMQPsPL____
Q9UBK2 S539 SIGNOR PPARGC1A LEM6 PGC1 PGC1A PPARGC1 DKLSYPWDGTQSYSLFNVSPsCSSFNSPCRDSVSPPKSLFS
Q9UBK2 T178 SIGNOR PPARGC1A LEM6 PGC1 PGC1A PPARGC1 YNECSGLSTQNHANHNHRIRtNPAIVKTENSWSNKAKSICQ
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UNF1 S85 Sugiyama MAGED2 BCG1 KAtEVsKtPEAREAPAtQAssttQLtDtQVLAAENKSLAAD
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQB8 S366 SIGNOR|EPSD|PSP BAIAP2 SVTPKNSYATtENKtLPRsssMAAGLERNGRMRVKAIFsHA
Q9UQK1 S33 SIGNOR PPP1R3C PPP1R5 RPLTSSVMPVDVAMRLCLAHsPPVKSFLGPYDEFQRRHFVN
Q9UQL6 S259 SIGNOR|EPSD|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR|EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y243 S472 Sugiyama AKT3 PKBG YDEDGMDCMDNERRPHFPQFsysAsGRE_____________
Q9Y243 S474 Sugiyama AKT3 PKBG EDGMDCMDNERRPHFPQFsysAsGRE_______________
Q9Y243 S476 Sugiyama AKT3 PKBG GMDCMDNERRPHFPQFsysAsGRE_________________
Q9Y243 Y473 Sugiyama AKT3 PKBG DEDGMDCMDNERRPHFPQFsysAsGRE______________
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2I7 S307 SIGNOR PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2T7 T115 SIGNOR YBX2 CSDA3 MSY2 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL
Q9Y478 S101 Sugiyama PRKAB1 AMPK VFRWTGGGKEVYLSGsFNNWsKLPLtRsHNNFVAILDLPEG
Q9Y478 S170 Sugiyama PRKAB1 AMPK NNIIQVKKtDFEVFDALMVDsQKCsDVsELsssPPGPyHQE
Q9Y478 S40 Sugiyama PRKAB1 AMPK PRRDssGGTKDGDRPKILMDsPEDADLFHsEEIKAPEKEEF
Q9Y478 S49 Sugiyama PRKAB1 AMPK KDGDRPKILMDsPEDADLFHsEEIKAPEKEEFLAWQHDLEV
Q9Y478 S96 Sugiyama PRKAB1 AMPK QARPtVFRWTGGGKEVYLSGsFNNWsKLPLtRsHNNFVAIL
Q9Y478 T158 Sugiyama PRKAB1 AMPK SEPIVTSQLGtVNNIIQVKKtDFEVFDALMVDsQKCsDVsE
Q9Y478 T80 Sugiyama PRKAB1 AMPK FLAWQHDLEVNDKAPAQARPtVFRWTGGGKEVYLSGsFNNW
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
NRAGE signals death through JNK R-HSA-193648 8.376700e-08 7.077 0 0
Signal Transduction R-HSA-162582 1.068086e-07 6.971 1 0
Cell Cycle R-HSA-1640170 1.644468e-07 6.784 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.680706e-07 6.775 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.088876e-07 6.510 0 0
G alpha (12/13) signalling events R-HSA-416482 4.670993e-07 6.331 0 0
Axon guidance R-HSA-422475 9.129110e-07 6.040 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.011347e-06 5.521 0 0
Mitotic Prometaphase R-HSA-68877 5.079796e-06 5.294 0 0
Nervous system development R-HSA-9675108 7.160657e-06 5.145 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.940036e-05 4.712 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.940036e-05 4.712 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.419285e-05 4.466 0 0
Cell Cycle, Mitotic R-HSA-69278 4.459760e-05 4.351 0 0
Apoptotic execution phase R-HSA-75153 4.356763e-05 4.361 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.292173e-05 4.367 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.784082e-05 4.320 0 0
Death Receptor Signaling R-HSA-73887 8.725453e-05 4.059 0 0
Cell Cycle Checkpoints R-HSA-69620 1.335101e-04 3.874 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.432137e-04 3.844 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.707661e-04 3.768 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.963981e-04 3.707 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.101974e-04 3.677 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.135580e-04 3.670 0 0
M Phase R-HSA-68886 2.136034e-04 3.670 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.933631e-04 3.533 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.255063e-04 3.487 0 0
Regulation of TP53 Activity R-HSA-5633007 3.412323e-04 3.467 1 0
Sema4D in semaphorin signaling R-HSA-400685 5.899182e-04 3.229 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.819781e-04 3.235 0 0
Semaphorin interactions R-HSA-373755 6.555985e-04 3.183 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.083515e-04 3.150 0 0
TRP channels R-HSA-3295583 7.854998e-04 3.105 0 0
Signaling by RAS mutants R-HSA-6802949 8.750318e-04 3.058 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.750318e-04 3.058 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.750318e-04 3.058 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.750318e-04 3.058 0 0
RAF activation R-HSA-5673000 9.265242e-04 3.033 0 0
Muscle contraction R-HSA-397014 9.546064e-04 3.020 0 0
PI Metabolism R-HSA-1483255 9.605089e-04 3.017 0 0
Centrosome maturation R-HSA-380287 9.801778e-04 3.009 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.071963e-03 2.970 0 0
Cellular response to heat stress R-HSA-3371556 1.112482e-03 2.954 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.196548e-03 2.922 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.334388e-03 2.875 1 1
Activation of RAC1 R-HSA-428540 1.507062e-03 2.822 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.763500e-03 2.754 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.763500e-03 2.754 0 0
EPH-Ephrin signaling R-HSA-2682334 1.736863e-03 2.760 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.880995e-03 2.726 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.936122e-03 2.713 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.075053e-03 2.683 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.008921e-03 2.697 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.080038e-03 2.682 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.765745e-03 2.558 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.098401e-03 2.509 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.257693e-03 2.487 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.525825e-03 2.453 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.125437e-03 2.385 0 0
Neurodegenerative Diseases R-HSA-8863678 4.130741e-03 2.384 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.130741e-03 2.384 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.053480e-03 2.392 0 0
DAG and IP3 signaling R-HSA-1489509 4.239353e-03 2.373 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.261009e-03 2.370 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.261009e-03 2.370 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.591020e-03 2.338 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.612966e-03 2.336 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.224768e-03 2.282 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.111101e-03 2.291 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.850436e-03 2.314 0 0
Homology Directed Repair R-HSA-5693538 4.856794e-03 2.314 0 0
HDMs demethylate histones R-HSA-3214842 5.235243e-03 2.281 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.109751e-03 2.292 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.681431e-03 2.246 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.681431e-03 2.246 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.451571e-03 2.263 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.689853e-03 2.245 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.880222e-03 2.231 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.571726e-03 2.254 0 0
Programmed Cell Death R-HSA-5357801 5.850616e-03 2.233 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.681431e-03 2.246 0 0
Post NMDA receptor activation events R-HSA-438064 5.959283e-03 2.225 1 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.969136e-03 2.224 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.017687e-03 2.221 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.355660e-03 2.197 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.355660e-03 2.197 0 0
Apoptosis R-HSA-109581 6.487568e-03 2.188 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.684356e-03 2.175 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.715318e-03 2.173 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.877608e-03 2.163 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.877608e-03 2.163 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.667578e-03 2.115 0 0
ALK mutants bind TKIs R-HSA-9700645 7.667578e-03 2.115 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.482089e-03 2.126 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.672990e-03 2.115 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.827669e-03 2.106 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.135627e-03 2.090 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.242157e-03 2.084 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.290041e-03 2.081 0 0
Mitotic Anaphase R-HSA-68882 8.540643e-03 2.069 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.824757e-03 2.054 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.031523e-03 2.044 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.167337e-03 2.038 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.522748e-03 2.021 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.001403e-02 1.999 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.001403e-02 1.999 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.001403e-02 1.999 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.001403e-02 1.999 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.001403e-02 1.999 0 0
Glycolysis R-HSA-70171 9.541966e-03 2.020 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.080269e-02 1.966 0 0
Integrin signaling R-HSA-354192 1.058958e-02 1.975 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.058958e-02 1.975 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.058958e-02 1.975 0 0
Signaling by VEGF R-HSA-194138 1.059664e-02 1.975 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.080425e-02 1.966 0 0
Signaling by ROBO receptors R-HSA-376176 1.117081e-02 1.952 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.215099e-02 1.915 0 0
Separation of Sister Chromatids R-HSA-2467813 1.222452e-02 1.913 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.267927e-02 1.897 0 0
Neurexins and neuroligins R-HSA-6794361 1.272736e-02 1.895 0 0
mRNA Splicing R-HSA-72172 1.285055e-02 1.891 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.383714e-02 1.859 0 0
Long-term potentiation R-HSA-9620244 1.387359e-02 1.858 0 0
Signaling by NTRKs R-HSA-166520 1.373914e-02 1.862 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.493294e-02 1.826 1 0
Co-stimulation by CD28 R-HSA-389356 1.494357e-02 1.826 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.521651e-02 1.818 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.534263e-02 1.814 0 0
snRNP Assembly R-HSA-191859 1.617335e-02 1.791 0 0
Metabolism of non-coding RNA R-HSA-194441 1.617335e-02 1.791 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.795500e-02 1.746 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.762472e-02 1.754 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.762472e-02 1.754 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.777699e-02 1.750 0 0
Netrin-1 signaling R-HSA-373752 1.755931e-02 1.755 0 0
Trafficking of AMPA receptors R-HSA-399719 1.752132e-02 1.756 0 0
G2/M Transition R-HSA-69275 1.797959e-02 1.745 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.950125e-02 1.710 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.950125e-02 1.710 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.950125e-02 1.710 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.950125e-02 1.710 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.939920e-02 1.712 0 0
Notch-HLH transcription pathway R-HSA-350054 1.934159e-02 1.714 0 0
Chromatin modifying enzymes R-HSA-3247509 1.886223e-02 1.724 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.015211e-02 1.696 0 0
Cardiac conduction R-HSA-5576891 1.935404e-02 1.713 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.033224e-02 1.692 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.068809e-02 1.684 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.068809e-02 1.684 0 0
Type I hemidesmosome assembly R-HSA-446107 2.074059e-02 1.683 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.074059e-02 1.683 0 0
G0 and Early G1 R-HSA-1538133 2.078973e-02 1.682 0 0
Calmodulin induced events R-HSA-111933 2.085967e-02 1.681 0 0
CaM pathway R-HSA-111997 2.085967e-02 1.681 0 0
Ion homeostasis R-HSA-5578775 2.161404e-02 1.665 0 0
Rap1 signalling R-HSA-392517 2.199957e-02 1.658 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.448591e-02 1.611 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.430672e-02 1.614 0 0
HSF1-dependent transactivation R-HSA-3371571 2.245800e-02 1.649 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.334326e-02 1.632 0 0
Diseases of DNA repair R-HSA-9675135 2.322050e-02 1.634 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.448591e-02 1.611 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.670832e-02 1.573 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.717146e-02 1.566 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.717146e-02 1.566 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.717146e-02 1.566 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.717146e-02 1.566 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.717146e-02 1.566 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.717146e-02 1.566 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.749699e-02 1.561 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.815405e-02 1.550 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.815405e-02 1.550 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.865750e-02 1.543 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.865750e-02 1.543 0 0
Platelet calcium homeostasis R-HSA-418360 2.874882e-02 1.541 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.907713e-02 1.536 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.025234e-02 1.519 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.375182e-02 1.472 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.377334e-02 1.471 0 0
Signaling by ERBB2 R-HSA-1227986 3.455871e-02 1.461 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.351773e-02 1.475 1 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.440393e-02 1.463 0 0
Interleukin-12 signaling R-HSA-9020591 3.217423e-02 1.492 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.487304e-02 1.458 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.487304e-02 1.458 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.582475e-02 1.446 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.713891e-02 1.430 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.816167e-02 1.418 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.825984e-02 1.417 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.841188e-02 1.416 0 0
PLC beta mediated events R-HSA-112043 3.853076e-02 1.414 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.938101e-02 1.405 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.938101e-02 1.405 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.955792e-02 1.403 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.986823e-02 1.399 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.231758e-02 1.373 0 0
Heme signaling R-HSA-9707616 4.282204e-02 1.368 0 0
Signaling by APC mutants R-HSA-4839744 4.961189e-02 1.304 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.961189e-02 1.304 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.961189e-02 1.304 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.961189e-02 1.304 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.710352e-02 1.327 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.559735e-02 1.341 0 0
Polo-like kinase mediated events R-HSA-156711 4.639481e-02 1.334 0 0
MAP2K and MAPK activation R-HSA-5674135 4.797830e-02 1.319 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.797830e-02 1.319 0 0
Chromatin organization R-HSA-4839726 4.366383e-02 1.360 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.797830e-02 1.319 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.385524e-02 1.358 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.408098e-02 1.356 0 0
MAPK family signaling cascades R-HSA-5683057 4.979463e-02 1.303 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.996451e-02 1.301 0 0
L1CAM interactions R-HSA-373760 5.039348e-02 1.298 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.244440e-02 1.280 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.244440e-02 1.280 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.244440e-02 1.280 0 0
Potassium Channels R-HSA-1296071 5.341839e-02 1.272 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.374319e-02 1.270 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.374319e-02 1.270 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.374319e-02 1.270 0 0
Dopamine receptors R-HSA-390651 5.374319e-02 1.270 0 0
Glucose metabolism R-HSA-70326 5.412980e-02 1.267 0 0
MTOR signalling R-HSA-165159 5.413705e-02 1.267 1 0
Ca-dependent events R-HSA-111996 5.413705e-02 1.267 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.416131e-02 1.266 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.420136e-02 1.266 0 0
Regulation of PTEN localization R-HSA-8948747 5.420136e-02 1.266 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.420136e-02 1.266 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.425497e-02 1.266 0 0
Signaling by NOTCH1 R-HSA-1980143 5.512391e-02 1.259 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.568324e-02 1.254 0 0
The NLRP3 inflammasome R-HSA-844456 5.568324e-02 1.254 0 0
Interleukin-12 family signaling R-HSA-447115 5.682129e-02 1.245 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.708221e-02 1.243 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.179308e-02 1.209 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.158963e-02 1.210 0 0
NGF-stimulated transcription R-HSA-9031628 5.725580e-02 1.242 0 0
Mitotic Prophase R-HSA-68875 6.652426e-02 1.177 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.737192e-02 1.241 0 0
Sodium/Calcium exchangers R-HSA-425561 6.274091e-02 1.202 0 0
Kinesins R-HSA-983189 6.179308e-02 1.209 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.274091e-02 1.202 0 0
Signaling by AXIN mutants R-HSA-4839735 6.274091e-02 1.202 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.581482e-02 1.182 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.994047e-02 1.222 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.444558e-02 1.191 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.444558e-02 1.191 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.736869e-02 1.172 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 6.736869e-02 1.172 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.736869e-02 1.172 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.800123e-02 1.167 0 0
Nuclear import of Rev protein R-HSA-180746 6.809983e-02 1.167 0 0
G-protein mediated events R-HSA-112040 6.942931e-02 1.158 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.165220e-02 1.145 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.165220e-02 1.145 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.181528e-02 1.144 0 0
Formation of the nephric duct R-HSA-9830364 7.490226e-02 1.126 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.572692e-02 1.121 0 0
Neuronal System R-HSA-112316 7.661356e-02 1.116 1 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.693249e-02 1.114 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.721452e-02 1.112 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.721452e-02 1.112 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.721452e-02 1.112 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.721452e-02 1.112 0 0
NrCAM interactions R-HSA-447038 7.721452e-02 1.112 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.750169e-02 1.111 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.763867e-02 1.110 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.780373e-02 1.109 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.881969e-02 1.103 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.098197e-02 1.041 0 0
ARMS-mediated activation R-HSA-170984 9.098197e-02 1.041 0 0
Lipophagy R-HSA-9613354 9.098197e-02 1.041 1 1
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.316088e-02 1.031 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.316088e-02 1.031 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.010847e-02 1.045 0 0
mRNA 3'-end processing R-HSA-72187 8.625463e-02 1.064 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.376447e-02 1.077 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.839746e-02 1.054 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.517666e-02 1.021 0 0
IGF1R signaling cascade R-HSA-2428924 8.905087e-02 1.050 0 0
Recycling pathway of L1 R-HSA-437239 9.279657e-02 1.032 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.098197e-02 1.041 0 0
Signaling by WNT in cancer R-HSA-4791275 9.214749e-02 1.036 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.597575e-02 1.066 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.765274e-02 1.057 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.985437e-02 1.046 0 0
Rab regulation of trafficking R-HSA-9007101 8.149734e-02 1.089 0 0
Smooth Muscle Contraction R-HSA-445355 9.472300e-02 1.024 0 0
FLT3 Signaling R-HSA-9607240 8.095270e-02 1.092 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.959983e-02 1.048 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 9.098197e-02 1.041 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.272054e-02 1.082 0 0
Specification of primordial germ cells R-HSA-9827857 9.316088e-02 1.031 0 0
Signaling by ALK in cancer R-HSA-9700206 8.272054e-02 1.082 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.604786e-02 1.018 0 0
Voltage gated Potassium channels R-HSA-1296072 9.663594e-02 1.015 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.663594e-02 1.015 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.689256e-02 1.014 0 0
Diseases of programmed cell death R-HSA-9645723 9.706183e-02 1.013 0 0
Peptide chain elongation R-HSA-156902 9.706183e-02 1.013 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.795340e-02 1.009 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.795340e-02 1.009 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.795340e-02 1.009 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.795340e-02 1.009 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.035586e-01 0.985 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.043712e-01 0.981 0 0
TRAIL signaling R-HSA-75158 1.043712e-01 0.981 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.043712e-01 0.981 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.046452e-01 0.980 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.046452e-01 0.980 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.046452e-01 0.980 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.046452e-01 0.980 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.046452e-01 0.980 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.050305e-01 0.979 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.052887e-01 0.978 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.088054e-01 0.963 0 0
Ephrin signaling R-HSA-3928664 1.088054e-01 0.963 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.088054e-01 0.963 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.088054e-01 0.963 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.310547e-01 0.883 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.310547e-01 0.883 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.094992e-01 0.961 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.094992e-01 0.961 0 0
Potassium transport channels R-HSA-1296067 1.094992e-01 0.961 0 0
CREB phosphorylation R-HSA-199920 1.346860e-01 0.871 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.346860e-01 0.871 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.128638e-01 0.947 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.368190e-01 0.864 0 0
DCC mediated attractive signaling R-HSA-418885 1.323901e-01 0.878 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.323901e-01 0.878 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.339637e-01 0.873 0 0
Striated Muscle Contraction R-HSA-390522 1.157345e-01 0.937 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.327254e-01 0.877 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.179990e-01 0.928 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.297966e-01 0.887 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.136115e-01 0.945 1 1
Apoptosis induced DNA fragmentation R-HSA-140342 1.128638e-01 0.947 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.128638e-01 0.947 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.286599e-01 0.891 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.169525e-01 0.932 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.157345e-01 0.937 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.214873e-01 0.915 0 0
Bicarbonate transporters R-HSA-425381 1.368190e-01 0.864 0 0
Nef and signal transduction R-HSA-164944 1.346860e-01 0.871 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.230744e-01 0.910 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.128638e-01 0.947 0 0
Syndecan interactions R-HSA-3000170 1.183009e-01 0.927 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.230744e-01 0.910 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.312378e-01 0.882 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.391544e-01 0.857 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.437921e-01 0.842 0 0
Nephrin family interactions R-HSA-373753 1.437921e-01 0.842 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.439521e-01 0.842 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.440740e-01 0.841 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.448392e-01 0.839 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.448392e-01 0.839 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.449958e-01 0.839 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.487433e-01 0.828 1 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 1.505901e-01 0.822 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.505901e-01 0.822 0 0
FOXO-mediated transcription R-HSA-9614085 1.507097e-01 0.822 0 0
Signaling by WNT R-HSA-195721 1.511313e-01 0.821 0 0
G2/M Checkpoints R-HSA-69481 1.528349e-01 0.816 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.536773e-01 0.813 0 0
Prolonged ERK activation events R-HSA-169893 1.536773e-01 0.813 0 0
Activation of SMO R-HSA-5635838 1.536773e-01 0.813 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.536773e-01 0.813 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.536773e-01 0.813 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.449406e-01 0.611 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.449406e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.449406e-01 0.611 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.449406e-01 0.611 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.449406e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.449406e-01 0.611 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.449406e-01 0.611 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.449406e-01 0.611 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.449406e-01 0.611 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.449406e-01 0.611 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.449406e-01 0.611 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.449406e-01 0.611 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.449406e-01 0.611 0 0
Axonal growth stimulation R-HSA-209563 1.566074e-01 0.805 0 0
HCN channels R-HSA-1296061 2.066665e-01 0.685 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.066665e-01 0.685 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.066665e-01 0.685 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.439061e-01 0.464 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.439061e-01 0.464 0 0
Mitochondrial transcription initiation R-HSA-163282 3.439061e-01 0.464 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.439061e-01 0.464 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.439061e-01 0.464 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.439061e-01 0.464 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.439061e-01 0.464 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 3.439061e-01 0.464 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.439061e-01 0.464 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.439061e-01 0.464 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.439061e-01 0.464 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.439061e-01 0.464 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.439061e-01 0.464 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.439061e-01 0.464 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.439061e-01 0.464 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.439061e-01 0.464 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.439061e-01 0.464 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.439061e-01 0.464 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.439061e-01 0.464 0 0
Intestinal infectious diseases R-HSA-8942233 3.439061e-01 0.464 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.439061e-01 0.464 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.675962e-01 0.776 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.675962e-01 0.776 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.675962e-01 0.776 0 0
SOS-mediated signalling R-HSA-112412 1.675962e-01 0.776 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.675962e-01 0.776 0 0
IRS activation R-HSA-74713 2.580947e-01 0.588 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.580947e-01 0.588 0 0
G2 Phase R-HSA-68911 2.580947e-01 0.588 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.580947e-01 0.588 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.025366e-01 0.693 0 0
Regulation by c-FLIP R-HSA-3371378 2.025366e-01 0.693 0 0
Dimerization of procaspase-8 R-HSA-69416 2.025366e-01 0.693 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.025366e-01 0.693 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.025366e-01 0.693 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.025366e-01 0.693 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.626148e-01 0.789 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.626148e-01 0.789 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.899984e-01 0.721 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.899984e-01 0.721 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.389624e-01 0.622 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.389624e-01 0.622 0 0
CASP8 activity is inhibited R-HSA-5218900 2.389624e-01 0.622 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.096739e-01 0.509 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.096739e-01 0.509 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.096739e-01 0.509 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.096739e-01 0.509 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.096739e-01 0.509 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.096739e-01 0.509 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.096739e-01 0.509 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.096739e-01 0.509 0 0
Signaling by MAPK mutants R-HSA-9652817 3.096739e-01 0.509 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.299052e-01 0.367 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.299052e-01 0.367 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.299052e-01 0.367 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.299052e-01 0.367 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.299052e-01 0.367 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.762742e-01 0.754 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.187058e-01 0.660 0 0
PI3K/AKT activation R-HSA-198203 2.763641e-01 0.559 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.763641e-01 0.559 1 1
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.763641e-01 0.559 0 0
cGMP effects R-HSA-418457 2.484706e-01 0.605 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.681258e-01 0.774 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.247996e-01 0.648 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.142774e-01 0.503 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.142774e-01 0.503 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.707265e-01 0.768 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.790302e-01 0.554 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.790302e-01 0.554 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.790302e-01 0.554 0 0
RET signaling R-HSA-8853659 1.566711e-01 0.805 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.263512e-01 0.645 0 0
Telomere Extension By Telomerase R-HSA-171319 2.056711e-01 0.687 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.051974e-01 0.688 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.255386e-01 0.647 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.255386e-01 0.647 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.101314e-01 0.508 0 0
Phosphorylation of the APC/C R-HSA-176412 3.101314e-01 0.508 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.101314e-01 0.508 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.522883e-01 0.453 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.522883e-01 0.453 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.098346e-01 0.387 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.098346e-01 0.387 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.098346e-01 0.387 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.098346e-01 0.387 0 0
Disinhibition of SNARE formation R-HSA-114516 4.098346e-01 0.387 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.046361e-01 0.297 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.046361e-01 0.297 0 0
Invadopodia formation R-HSA-8941237 5.046361e-01 0.297 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.046361e-01 0.297 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.046361e-01 0.297 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 5.046361e-01 0.297 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.046361e-01 0.297 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.460337e-01 0.609 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.460337e-01 0.609 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.460337e-01 0.609 1 1
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.035243e-01 0.518 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.415345e-01 0.467 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.415345e-01 0.467 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.797888e-01 0.745 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.900349e-01 0.409 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.900349e-01 0.409 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.307058e-01 0.481 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.284478e-01 0.641 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.015170e-01 0.696 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.236893e-01 0.650 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.203154e-01 0.494 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.203154e-01 0.494 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.730163e-01 0.428 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.730163e-01 0.428 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.572413e-01 0.340 0 0
RSK activation R-HSA-444257 4.572413e-01 0.340 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.572413e-01 0.340 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.439648e-01 0.613 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.755087e-01 0.756 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.782419e-01 0.749 0 0
HIV elongation arrest and recovery R-HSA-167287 3.447612e-01 0.462 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.447612e-01 0.462 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.272072e-01 0.369 0 0
Formation of axial mesoderm R-HSA-9796292 4.272072e-01 0.369 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.215306e-01 0.493 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.296731e-01 0.639 0 0
Late endosomal microautophagy R-HSA-9615710 3.693709e-01 0.433 0 0
HIV Transcription Elongation R-HSA-167169 3.421449e-01 0.466 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.421449e-01 0.466 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.421449e-01 0.466 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.237474e-01 0.650 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.237474e-01 0.650 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.129564e-01 0.384 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.129564e-01 0.384 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.635449e-01 0.334 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.635449e-01 0.334 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.635449e-01 0.334 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.023642e-01 0.299 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.023642e-01 0.299 0 0
Interleukin-21 signaling R-HSA-9020958 5.023642e-01 0.299 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.023642e-01 0.299 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.695747e-01 0.244 0 0
NADE modulates death signalling R-HSA-205025 5.695747e-01 0.244 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.695747e-01 0.244 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.695747e-01 0.244 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.695747e-01 0.244 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.695747e-01 0.244 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.695747e-01 0.244 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.695747e-01 0.244 0 0
G1/S-Specific Transcription R-HSA-69205 4.001691e-01 0.398 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.659902e-01 0.332 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.190274e-01 0.496 0 0
Viral mRNA Translation R-HSA-192823 3.416043e-01 0.466 0 0
Transcription of the HIV genome R-HSA-167172 3.819989e-01 0.418 0 0
Erythropoietin activates RAS R-HSA-9027284 4.988350e-01 0.302 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.988350e-01 0.302 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.988350e-01 0.302 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.988350e-01 0.302 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.959446e-01 0.305 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.959446e-01 0.305 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 4.959446e-01 0.305 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.959446e-01 0.305 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.449875e-01 0.264 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.449875e-01 0.264 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.935355e-01 0.307 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.935355e-01 0.307 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.935355e-01 0.307 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.332629e-01 0.363 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.914616e-01 0.309 0 0
Attenuation phase R-HSA-3371568 4.896296e-01 0.310 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.251587e-01 0.280 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.864715e-01 0.313 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.195146e-01 0.284 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.195146e-01 0.284 1 1
Signaling by NOTCH2 R-HSA-1980145 5.150880e-01 0.288 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.150880e-01 0.288 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.083473e-01 0.294 0 0
PERK regulates gene expression R-HSA-381042 5.382815e-01 0.269 0 0
Signaling by Erythropoietin R-HSA-9006335 5.449083e-01 0.264 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.449083e-01 0.264 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.535290e-01 0.257 0 0
FGFR2 alternative splicing R-HSA-6803529 5.535290e-01 0.257 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.656300e-01 0.247 0 0
Phase 2 - plateau phase R-HSA-5576893 5.656300e-01 0.247 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.849912e-01 0.233 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.849912e-01 0.233 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.849912e-01 0.233 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.260035e-01 0.203 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.260035e-01 0.203 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.260035e-01 0.203 0 0
HSF1 activation R-HSA-3371511 5.609840e-01 0.251 0 0
DAP12 signaling R-HSA-2424491 5.696465e-01 0.244 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.809703e-01 0.236 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.809703e-01 0.236 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.969076e-01 0.224 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.969076e-01 0.224 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.969076e-01 0.224 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.223296e-01 0.206 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.223296e-01 0.206 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.223296e-01 0.206 0 0
ERKs are inactivated R-HSA-202670 6.223296e-01 0.206 0 0
Signaling by FGFR2 R-HSA-5654738 5.794677e-01 0.237 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.382815e-01 0.269 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.693709e-01 0.433 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.940415e-01 0.404 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.382815e-01 0.269 0 0
EGFR downregulation R-HSA-182971 5.936693e-01 0.226 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.590513e-01 0.798 0 0
Circadian clock R-HSA-9909396 4.239972e-01 0.373 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.590513e-01 0.798 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.841073e-01 0.547 0 0
DNA Double Strand Break Response R-HSA-5693606 1.771229e-01 0.752 0 0
Specification of the neural plate border R-HSA-9834899 2.504117e-01 0.601 0 0
Signaling by FGFR3 R-HSA-5654741 4.673907e-01 0.330 0 0
Signaling by FGFR4 R-HSA-5654743 4.257468e-01 0.371 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.850993e-01 0.314 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.155182e-01 0.501 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.936693e-01 0.226 0 0
ESR-mediated signaling R-HSA-8939211 3.973411e-01 0.401 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.272072e-01 0.369 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.685315e-01 0.571 0 0
Signaling by EGFR R-HSA-177929 4.112880e-01 0.386 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.969076e-01 0.224 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.905640e-01 0.229 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.905640e-01 0.229 0 0
Extension of Telomeres R-HSA-180786 3.436222e-01 0.464 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.675962e-01 0.776 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.104678e-01 0.508 0 0
IRS-mediated signalling R-HSA-112399 3.093936e-01 0.509 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.656300e-01 0.247 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.061764e-01 0.391 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.722538e-01 0.326 0 0
Insulin receptor signalling cascade R-HSA-74751 3.160198e-01 0.500 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.905640e-01 0.229 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.899984e-01 0.721 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.373566e-01 0.472 0 0
Signaling by FGFR1 R-HSA-5654736 5.433058e-01 0.265 0 0
Aggrephagy R-HSA-9646399 3.421449e-01 0.466 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.656300e-01 0.247 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.223296e-01 0.206 0 0
Signal attenuation R-HSA-74749 2.763641e-01 0.559 0 0
Myogenesis R-HSA-525793 4.670526e-01 0.331 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.959446e-01 0.305 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.690671e-01 0.245 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.236221e-01 0.205 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.803182e-01 0.420 0 0
Frs2-mediated activation R-HSA-170968 2.187058e-01 0.660 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.205957e-01 0.376 0 0
MHC class II antigen presentation R-HSA-2132295 4.617543e-01 0.336 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.626148e-01 0.789 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.763641e-01 0.559 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.763641e-01 0.559 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.263512e-01 0.645 0 0
PI3K Cascade R-HSA-109704 3.016180e-01 0.521 0 0
DARPP-32 events R-HSA-180024 5.449083e-01 0.264 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.074150e-01 0.217 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.346447e-01 0.475 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.155534e-01 0.381 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.857490e-01 0.731 0 0
Selective autophagy R-HSA-9663891 2.120054e-01 0.674 1 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.885635e-01 0.230 1 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.415345e-01 0.467 0 0
Signalling to ERKs R-HSA-187687 2.421455e-01 0.616 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.449083e-01 0.264 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.656971e-01 0.781 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.675962e-01 0.776 0 0
Formation of apoptosome R-HSA-111458 2.763641e-01 0.559 0 0
LGI-ADAM interactions R-HSA-5682910 3.142774e-01 0.503 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.098346e-01 0.387 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.572413e-01 0.340 0 0
Processing of SMDT1 R-HSA-8949664 4.272072e-01 0.369 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.023642e-01 0.299 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.155534e-01 0.381 0 0
Regulation of CDH11 function R-HSA-9762292 5.449875e-01 0.264 0 0
Intra-Golgi traffic R-HSA-6811438 5.329277e-01 0.273 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.535290e-01 0.257 0 0
Meiotic recombination R-HSA-912446 5.867535e-01 0.232 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.223296e-01 0.206 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.491507e-01 0.348 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.760707e-01 0.559 0 0
Autophagy R-HSA-9612973 2.014168e-01 0.696 1 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.150880e-01 0.288 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.479483e-01 0.349 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.504117e-01 0.601 0 0
TNF signaling R-HSA-75893 1.956469e-01 0.709 0 0
Formation of definitive endoderm R-HSA-9823730 2.767070e-01 0.558 0 0
Interleukin-9 signaling R-HSA-8985947 4.572413e-01 0.340 0 0
Triglyceride catabolism R-HSA-163560 4.001691e-01 0.398 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.681258e-01 0.774 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.390105e-01 0.268 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.580947e-01 0.588 0 0
Adrenoceptors R-HSA-390696 2.025366e-01 0.693 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.899984e-01 0.721 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.899984e-01 0.721 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.389624e-01 0.622 1 1
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.604817e-01 0.443 0 0
Apoptotic factor-mediated response R-HSA-111471 2.247996e-01 0.648 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.101314e-01 0.508 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 4.272072e-01 0.369 0 0
WNT mediated activation of DVL R-HSA-201688 5.023642e-01 0.299 0 0
Meiosis R-HSA-1500620 3.311161e-01 0.480 0 0
Cellular response to starvation R-HSA-9711097 3.490181e-01 0.457 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.260035e-01 0.203 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.609840e-01 0.251 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.160731e-01 0.210 0 0
NF-kB is activated and signals survival R-HSA-209560 6.223296e-01 0.206 0 0
Opioid Signalling R-HSA-111885 1.979450e-01 0.703 0 0
Macroautophagy R-HSA-1632852 2.348447e-01 0.629 1 1
CD209 (DC-SIGN) signaling R-HSA-5621575 2.490464e-01 0.604 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.535290e-01 0.257 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.655044e-01 0.781 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.961406e-01 0.529 0 0
Regulated Necrosis R-HSA-5218859 1.891322e-01 0.723 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.025366e-01 0.693 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.763641e-01 0.559 0 0
Repression of WNT target genes R-HSA-4641265 3.900349e-01 0.409 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.449083e-01 0.264 0 0
Hedgehog 'on' state R-HSA-5632684 4.323619e-01 0.364 0 0
Signaling by Hippo R-HSA-2028269 2.000335e-01 0.699 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.832187e-01 0.737 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.421455e-01 0.616 0 0
Integration of energy metabolism R-HSA-163685 1.898679e-01 0.722 1 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.626148e-01 0.789 0 0
Calcineurin activates NFAT R-HSA-2025928 2.389624e-01 0.622 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.299052e-01 0.367 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.522883e-01 0.453 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.098346e-01 0.387 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.046361e-01 0.297 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.844412e-01 0.734 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.415345e-01 0.467 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.730163e-01 0.428 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.572413e-01 0.340 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.572413e-01 0.340 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.572413e-01 0.340 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.572413e-01 0.340 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.272072e-01 0.369 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.272072e-01 0.369 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.043725e-01 0.393 0 0
Arachidonate production from DAG R-HSA-426048 5.449875e-01 0.264 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.449875e-01 0.264 0 0
DNA Repair R-HSA-73894 2.790547e-01 0.554 0 0
Meiotic synapsis R-HSA-1221632 4.864715e-01 0.313 0 0
Formation of the posterior neural plate R-HSA-9832991 5.849912e-01 0.233 0 0
Activation of AKT2 R-HSA-165158 6.260035e-01 0.203 0 0
PTK6 Down-Regulation R-HSA-8849472 6.260035e-01 0.203 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.969076e-01 0.224 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.050306e-01 0.218 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.223296e-01 0.206 0 0
Interleukin-2 family signaling R-HSA-451927 2.204524e-01 0.657 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.671182e-01 0.331 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.263512e-01 0.645 0 0
Signaling by FGFR in disease R-HSA-1226099 3.690187e-01 0.433 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.104678e-01 0.508 0 0
Signaling by SCF-KIT R-HSA-1433557 1.862079e-01 0.730 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.681258e-01 0.774 0 0
Interleukin-2 signaling R-HSA-9020558 3.142774e-01 0.503 0 0
Activation of BH3-only proteins R-HSA-114452 2.460337e-01 0.609 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.685160e-01 0.245 0 0
Ca2+ pathway R-HSA-4086398 4.658905e-01 0.332 0 0
Regulation of KIT signaling R-HSA-1433559 4.635449e-01 0.334 0 0
Cilium Assembly R-HSA-5617833 2.730843e-01 0.564 0 0
Host Interactions of HIV factors R-HSA-162909 1.724142e-01 0.763 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.371568e-01 0.472 1 0
FasL/ CD95L signaling R-HSA-75157 1.566074e-01 0.805 0 0
Signaling by LTK R-HSA-9842663 1.899984e-01 0.721 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.187058e-01 0.660 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.763641e-01 0.559 0 0
Leukotriene receptors R-HSA-391906 3.604817e-01 0.443 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.681258e-01 0.774 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.790302e-01 0.554 0 0
G-protein beta:gamma signalling R-HSA-397795 1.876244e-01 0.727 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.522883e-01 0.453 0 0
Eukaryotic Translation Termination R-HSA-72764 2.412985e-01 0.617 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.023642e-01 0.299 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.695747e-01 0.244 0 0
Nuclear RNA decay R-HSA-9930044 4.674678e-01 0.330 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.488773e-01 0.261 0 0
Complex III assembly R-HSA-9865881 6.074150e-01 0.217 0 0
PTEN Regulation R-HSA-6807070 2.811239e-01 0.551 0 0
Membrane Trafficking R-HSA-199991 1.577109e-01 0.802 1 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.247996e-01 0.648 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.654087e-01 0.332 0 0
Mitochondrial biogenesis R-HSA-1592230 5.690014e-01 0.245 1 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.936693e-01 0.226 0 0
Transmission across Chemical Synapses R-HSA-112315 5.303357e-01 0.275 1 0
Gene expression (Transcription) R-HSA-74160 1.857188e-01 0.731 1 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.626148e-01 0.789 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.789149e-01 0.747 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.635449e-01 0.334 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.114458e-01 0.291 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.656300e-01 0.247 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.531187e-01 0.257 0 0
Developmental Biology R-HSA-1266738 5.465594e-01 0.262 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.055085e-01 0.687 0 0
Signaling by PTK6 R-HSA-8848021 2.055085e-01 0.687 0 0
Cellular responses to stress R-HSA-2262752 2.567304e-01 0.591 1 0
RNA Polymerase II Transcription R-HSA-73857 2.338318e-01 0.631 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.762663e-01 0.239 0 0
HIV Infection R-HSA-162906 2.029057e-01 0.693 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.580997e-01 0.446 0 0
Metabolism of RNA R-HSA-8953854 3.074032e-01 0.512 0 0
Deubiquitination R-HSA-5688426 5.627089e-01 0.250 0 0
Cellular responses to stimuli R-HSA-8953897 2.140929e-01 0.669 1 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.722201e-01 0.429 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.564849e-01 0.448 0 0
HIV Life Cycle R-HSA-162587 1.588917e-01 0.799 0 0
Generic Transcription Pathway R-HSA-212436 2.706687e-01 0.568 1 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.066665e-01 0.685 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.675962e-01 0.776 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.580947e-01 0.588 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.389624e-01 0.622 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.096739e-01 0.509 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.299052e-01 0.367 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.763641e-01 0.559 0 0
Metalloprotease DUBs R-HSA-5689901 1.681258e-01 0.774 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.247996e-01 0.648 0 0
mTORC1-mediated signalling R-HSA-166208 2.043726e-01 0.690 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.142774e-01 0.503 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.046361e-01 0.297 0 0
Amine ligand-binding receptors R-HSA-375280 2.013698e-01 0.696 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.900349e-01 0.409 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.572413e-01 0.340 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.572413e-01 0.340 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.572413e-01 0.340 0 0
Co-stimulation by ICOS R-HSA-9927354 4.572413e-01 0.340 0 0
Cellular Senescence R-HSA-2559583 1.911204e-01 0.719 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.984558e-01 0.525 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.047984e-01 0.393 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.136274e-01 0.383 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.914616e-01 0.309 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.260035e-01 0.203 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.831442e-01 0.234 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.074150e-01 0.217 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.223296e-01 0.206 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.841073e-01 0.547 0 0
Signaling by ERBB4 R-HSA-1236394 4.825531e-01 0.316 0 0
GPVI-mediated activation cascade R-HSA-114604 4.001691e-01 0.398 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.072745e-01 0.295 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.170369e-01 0.663 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.062996e-01 0.514 0 0
Platelet homeostasis R-HSA-418346 4.911566e-01 0.309 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.865090e-01 0.729 0 0
Protein methylation R-HSA-8876725 4.988350e-01 0.302 0 0
FLT3 signaling in disease R-HSA-9682385 5.609840e-01 0.251 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.449083e-01 0.264 0 0
Reproduction R-HSA-1474165 3.996033e-01 0.398 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.790302e-01 0.554 0 0
TBC/RABGAPs R-HSA-8854214 1.862079e-01 0.730 0 0
Selenocysteine synthesis R-HSA-2408557 2.352152e-01 0.629 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.695747e-01 0.244 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.819989e-01 0.418 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.656300e-01 0.247 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.142606e-01 0.669 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.033403e-01 0.692 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.674678e-01 0.330 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.885814e-01 0.540 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.323619e-01 0.364 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.237116e-01 0.490 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.096739e-01 0.509 0 0
CHL1 interactions R-HSA-447041 4.098346e-01 0.387 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.580997e-01 0.446 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.695747e-01 0.244 0 0
Protein hydroxylation R-HSA-9629569 4.659902e-01 0.332 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.260035e-01 0.203 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.177715e-01 0.286 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.685160e-01 0.245 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.165182e-01 0.210 0 0
Inflammasomes R-HSA-622312 2.056711e-01 0.687 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.988941e-01 0.223 0 0
Phospholipid metabolism R-HSA-1483257 3.043206e-01 0.517 0 0
Sensory processing of sound R-HSA-9659379 4.493558e-01 0.347 0 0
Downstream signal transduction R-HSA-186763 2.670755e-01 0.573 0 0
RUNX2 regulates bone development R-HSA-8941326 4.001691e-01 0.398 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.112880e-01 0.386 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.168484e-01 0.499 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.312379e-01 0.365 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.043725e-01 0.393 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.047839e-01 0.218 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.580997e-01 0.446 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.298278e-01 0.367 0 0
Interleukin-15 signaling R-HSA-8983432 3.900349e-01 0.409 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.307058e-01 0.481 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.209329e-01 0.283 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.969076e-01 0.224 0 0
Signaling by TGFB family members R-HSA-9006936 3.704785e-01 0.431 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.439061e-01 0.464 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.096739e-01 0.509 0 0
DSCAM interactions R-HSA-376172 4.299052e-01 0.367 0 0
Synthesis of PI R-HSA-1483226 3.142774e-01 0.503 0 0
Formation of the anterior neural plate R-HSA-9823739 2.790302e-01 0.554 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.255386e-01 0.647 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.307058e-01 0.481 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 5.023642e-01 0.299 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.695747e-01 0.244 0 0
Sensory perception of sour taste R-HSA-9729555 5.695747e-01 0.244 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.227373e-01 0.374 0 0
Serotonin receptors R-HSA-390666 5.449875e-01 0.264 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 5.449875e-01 0.264 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.032464e-01 0.298 0 0
Inositol transporters R-HSA-429593 6.260035e-01 0.203 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.897180e-01 0.229 0 0
Signaling by Interleukins R-HSA-449147 2.653602e-01 0.576 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.504117e-01 0.601 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.251587e-01 0.280 0 0
Stimuli-sensing channels R-HSA-2672351 2.514599e-01 0.600 0 0
Signaling by KIT in disease R-HSA-9669938 5.535290e-01 0.257 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.679326e-01 0.434 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.025366e-01 0.693 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.272072e-01 0.369 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.272072e-01 0.369 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.272072e-01 0.369 0 0
Carnitine shuttle R-HSA-200425 5.809703e-01 0.236 1 1
Histamine receptors R-HSA-390650 5.046361e-01 0.297 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.452144e-01 0.351 0 0
Signaling by ALK R-HSA-201556 4.675329e-01 0.330 0 0
PECAM1 interactions R-HSA-210990 5.849912e-01 0.233 0 0
Inositol phosphate metabolism R-HSA-1483249 3.832795e-01 0.416 0 0
Kidney development R-HSA-9830369 3.653150e-01 0.437 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.669851e-01 0.574 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.299052e-01 0.367 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.098346e-01 0.387 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.098346e-01 0.387 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.695747e-01 0.244 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.695747e-01 0.244 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.449875e-01 0.264 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 4.914616e-01 0.309 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.803182e-01 0.420 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.999472e-01 0.523 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.674678e-01 0.330 0 0
Maturation of nucleoprotein R-HSA-9694631 2.504117e-01 0.601 0 0
Metal ion SLC transporters R-HSA-425410 5.284484e-01 0.277 0 0
Growth hormone receptor signaling R-HSA-982772 5.809703e-01 0.236 0 0
Influenza Infection R-HSA-168255 1.837156e-01 0.736 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.096739e-01 0.509 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.790302e-01 0.554 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.098346e-01 0.387 0 0
OAS antiviral response R-HSA-8983711 3.900349e-01 0.409 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.023642e-01 0.299 0 0
Interleukin-1 processing R-HSA-448706 5.023642e-01 0.299 0 0
LDL clearance R-HSA-8964038 5.535290e-01 0.257 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.260035e-01 0.203 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.637968e-01 0.249 0 0
Regulation of beta-cell development R-HSA-186712 5.975739e-01 0.224 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.043725e-01 0.393 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.378051e-01 0.269 0 0
Nephron development R-HSA-9831926 4.043725e-01 0.393 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.959446e-01 0.305 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.251587e-01 0.280 0 0
tRNA processing in the nucleus R-HSA-6784531 5.212347e-01 0.283 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.023642e-01 0.299 0 0
Maturation of nucleoprotein R-HSA-9683610 4.272072e-01 0.369 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.256669e-01 0.204 0 0
Signaling by Leptin R-HSA-2586552 5.449875e-01 0.264 0 0
Interleukin-37 signaling R-HSA-9008059 3.940415e-01 0.404 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.266741e-01 0.203 0 0
PKA activation in glucagon signalling R-HSA-164378 6.266741e-01 0.203 0 0
Mismatch Repair R-HSA-5358508 6.266741e-01 0.203 0 0
PKA activation R-HSA-163615 6.266741e-01 0.203 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.266741e-01 0.203 0 0
Tie2 Signaling R-HSA-210993 6.266741e-01 0.203 0 0
Platelet sensitization by LDL R-HSA-432142 6.266741e-01 0.203 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.328112e-01 0.199 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.328112e-01 0.199 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.328112e-01 0.199 0 0
Tight junction interactions R-HSA-420029 6.328112e-01 0.199 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.328112e-01 0.199 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.328112e-01 0.199 0 0
Interleukin-7 signaling R-HSA-1266695 6.328112e-01 0.199 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.337808e-01 0.198 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.337808e-01 0.198 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.337808e-01 0.198 0 0
Signaling by TGFBR3 R-HSA-9839373 6.337808e-01 0.198 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.393808e-01 0.194 0 0
Cardiogenesis R-HSA-9733709 6.393808e-01 0.194 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.403244e-01 0.194 0 0
Translation initiation complex formation R-HSA-72649 6.413739e-01 0.193 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.413739e-01 0.193 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.416230e-01 0.193 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.416230e-01 0.193 0 0
Generation of second messenger molecules R-HSA-202433 6.459607e-01 0.190 0 0
Diseases of Immune System R-HSA-5260271 6.459607e-01 0.190 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.459607e-01 0.190 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.469940e-01 0.189 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.548903e-01 0.184 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.548903e-01 0.184 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.548903e-01 0.184 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.548903e-01 0.184 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.548903e-01 0.184 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.548903e-01 0.184 0 0
Other interleukin signaling R-HSA-449836 6.548903e-01 0.184 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.570140e-01 0.182 0 0
Polymerase switching R-HSA-69091 6.570140e-01 0.182 0 0
Leading Strand Synthesis R-HSA-69109 6.570140e-01 0.182 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.570140e-01 0.182 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.570140e-01 0.182 0 0
Regulation of IFNG signaling R-HSA-877312 6.570140e-01 0.182 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.570140e-01 0.182 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.570140e-01 0.182 0 0
MET activates RAS signaling R-HSA-8851805 6.570140e-01 0.182 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.570140e-01 0.182 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.570140e-01 0.182 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.570140e-01 0.182 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.571217e-01 0.182 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.571217e-01 0.182 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 6.571217e-01 0.182 0 0
Signaling by NOTCH3 R-HSA-9012852 6.586424e-01 0.181 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.609988e-01 0.180 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.655739e-01 0.177 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.655739e-01 0.177 0 0
Regulation of insulin secretion R-HSA-422356 6.666279e-01 0.176 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.692553e-01 0.174 0 0
Signaling by Insulin receptor R-HSA-74752 6.737384e-01 0.172 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.739401e-01 0.171 0 0
PKB-mediated events R-HSA-109703 6.750373e-01 0.171 0 0
PDE3B signalling R-HSA-165160 6.750373e-01 0.171 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.750373e-01 0.171 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.750373e-01 0.171 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.750373e-01 0.171 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.750373e-01 0.171 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.750373e-01 0.171 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.750373e-01 0.171 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.750373e-01 0.171 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.750373e-01 0.171 0 0
NGF-independant TRKA activation R-HSA-187024 6.750373e-01 0.171 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.750373e-01 0.171 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.750373e-01 0.171 0 0
Ceramide signalling R-HSA-193681 6.750373e-01 0.171 0 0
Formation of the Editosome R-HSA-75094 6.750373e-01 0.171 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.750373e-01 0.171 0 0
Phosphorylation of Emi1 R-HSA-176417 6.750373e-01 0.171 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.750373e-01 0.171 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.750373e-01 0.171 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.750373e-01 0.171 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.750373e-01 0.171 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.750373e-01 0.171 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.750373e-01 0.171 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.750373e-01 0.171 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.750373e-01 0.171 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.750373e-01 0.171 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.754106e-01 0.170 0 0
Ribosome-associated quality control R-HSA-9948299 6.780408e-01 0.169 0 0
HATs acetylate histones R-HSA-3214847 6.793728e-01 0.168 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.803225e-01 0.167 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.803225e-01 0.167 0 0
Insulin processing R-HSA-264876 6.803225e-01 0.167 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.815293e-01 0.167 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.815293e-01 0.167 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.815400e-01 0.167 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.815400e-01 0.167 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.815400e-01 0.167 0 0
Negative regulation of MET activity R-HSA-6807004 6.815400e-01 0.167 0 0
Signal transduction by L1 R-HSA-445144 6.815400e-01 0.167 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.817590e-01 0.166 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.817590e-01 0.166 0 0
Dual Incision in GG-NER R-HSA-5696400 6.817590e-01 0.166 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.817590e-01 0.166 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.837469e-01 0.165 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.844872e-01 0.165 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.844872e-01 0.165 0 0
Ion channel transport R-HSA-983712 6.855529e-01 0.164 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.878932e-01 0.162 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.878932e-01 0.162 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.886262e-01 0.162 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.890983e-01 0.162 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.890983e-01 0.162 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.890983e-01 0.162 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.890983e-01 0.162 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.890983e-01 0.162 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.890983e-01 0.162 0 0
Interleukin-6 signaling R-HSA-1059683 6.890983e-01 0.162 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.890983e-01 0.162 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.890983e-01 0.162 0 0
Hedgehog 'off' state R-HSA-5610787 6.918357e-01 0.160 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.941023e-01 0.159 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.024011e-01 0.153 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.024011e-01 0.153 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.024011e-01 0.153 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.024011e-01 0.153 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.024011e-01 0.153 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.026867e-01 0.153 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.026867e-01 0.153 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.026867e-01 0.153 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.047394e-01 0.152 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.061120e-01 0.151 1 1
Chromosome Maintenance R-HSA-73886 7.061120e-01 0.151 0 0
Lagging Strand Synthesis R-HSA-69186 7.066261e-01 0.151 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.066261e-01 0.151 0 0
Signalling to RAS R-HSA-167044 7.066261e-01 0.151 0 0
ERK/MAPK targets R-HSA-198753 7.066261e-01 0.151 0 0
Basigin interactions R-HSA-210991 7.066261e-01 0.151 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.066261e-01 0.151 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.073933e-01 0.150 0 0
S Phase R-HSA-69242 7.136358e-01 0.147 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.176449e-01 0.144 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.176449e-01 0.144 0 0
STAT5 Activation R-HSA-9645135 7.176449e-01 0.144 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.176449e-01 0.144 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.176449e-01 0.144 0 0
Hydrolysis of LPE R-HSA-1483152 7.176449e-01 0.144 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.176449e-01 0.144 0 0
Neurofascin interactions R-HSA-447043 7.176449e-01 0.144 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.176449e-01 0.144 0 0
NADPH regeneration R-HSA-389542 7.176449e-01 0.144 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 7.186682e-01 0.143 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.186682e-01 0.143 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.186682e-01 0.143 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.186682e-01 0.143 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.186682e-01 0.143 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.186682e-01 0.143 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.186682e-01 0.143 0 0
P2Y receptors R-HSA-417957 7.186682e-01 0.143 0 0
Zinc transporters R-HSA-435354 7.186682e-01 0.143 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.201635e-01 0.143 0 0
Triglyceride metabolism R-HSA-8979227 7.225890e-01 0.141 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.225890e-01 0.141 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.231135e-01 0.141 0 0
Gastrulation R-HSA-9758941 7.233071e-01 0.141 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.301675e-01 0.137 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.301675e-01 0.137 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.301675e-01 0.137 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.349191e-01 0.134 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.357296e-01 0.133 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.365868e-01 0.133 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.365868e-01 0.133 0 0
RMTs methylate histone arginines R-HSA-3214858 7.369133e-01 0.133 0 0
G1 Phase R-HSA-69236 7.369133e-01 0.133 0 0
Cyclin D associated events in G1 R-HSA-69231 7.369133e-01 0.133 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.372463e-01 0.132 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.424060e-01 0.129 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.458312e-01 0.127 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.458312e-01 0.127 0 0
Translesion synthesis by REV1 R-HSA-110312 7.458312e-01 0.127 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.458312e-01 0.127 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.458312e-01 0.127 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.458312e-01 0.127 0 0
p75NTR signals via NF-kB R-HSA-193639 7.458312e-01 0.127 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.458312e-01 0.127 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.458312e-01 0.127 0 0
p38MAPK events R-HSA-171007 7.458312e-01 0.127 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.458312e-01 0.127 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.458312e-01 0.127 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.458312e-01 0.127 0 0
Telomere Maintenance R-HSA-157579 7.471556e-01 0.127 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.511500e-01 0.124 0 0
Cell-Cell communication R-HSA-1500931 7.513785e-01 0.124 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.515807e-01 0.124 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.521962e-01 0.124 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.521962e-01 0.124 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.529358e-01 0.123 0 0
Nucleosome assembly R-HSA-774815 7.529358e-01 0.123 0 0
Signaling by Hedgehog R-HSA-5358351 7.539942e-01 0.123 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.546682e-01 0.122 0 0
Netrin mediated repulsion signals R-HSA-418886 7.546682e-01 0.122 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.546682e-01 0.122 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.546682e-01 0.122 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.546682e-01 0.122 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.546682e-01 0.122 0 0
Recycling of eIF2:GDP R-HSA-72731 7.546682e-01 0.122 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.546682e-01 0.122 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.546682e-01 0.122 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.546682e-01 0.122 0 0
VLDL clearance R-HSA-8964046 7.546682e-01 0.122 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.546682e-01 0.122 0 0
Activation of TRKA receptors R-HSA-187015 7.546682e-01 0.122 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.546682e-01 0.122 0 0
Maturation of replicase proteins R-HSA-9694301 7.546682e-01 0.122 0 0
Elastic fibre formation R-HSA-1566948 7.560279e-01 0.121 0 0
IRE1alpha activates chaperones R-HSA-381070 7.562741e-01 0.121 0 0
G1/S Transition R-HSA-69206 7.577385e-01 0.120 0 0
Signaling by FGFR R-HSA-190236 7.582495e-01 0.120 0 0
Nucleotide Excision Repair R-HSA-5696398 7.603763e-01 0.119 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.619274e-01 0.118 0 0
Budding and maturation of HIV virion R-HSA-162588 7.619274e-01 0.118 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.647937e-01 0.116 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.682349e-01 0.115 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.682349e-01 0.115 0 0
Translesion synthesis by POLI R-HSA-5656121 7.707101e-01 0.113 0 0
Differentiation of T cells R-HSA-9945266 7.707101e-01 0.113 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.707101e-01 0.113 0 0
Negative regulation of FLT3 R-HSA-9706369 7.707101e-01 0.113 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.707101e-01 0.113 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.707101e-01 0.113 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.707101e-01 0.113 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.727547e-01 0.112 0 0
Platelet degranulation R-HSA-114608 7.766161e-01 0.110 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.771885e-01 0.109 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.771885e-01 0.109 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.795809e-01 0.108 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.795809e-01 0.108 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.828174e-01 0.106 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.868387e-01 0.104 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.868387e-01 0.104 0 0
MET receptor recycling R-HSA-8875656 7.868387e-01 0.104 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.868387e-01 0.104 0 0
Formation of annular gap junctions R-HSA-196025 7.868387e-01 0.104 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.868387e-01 0.104 0 0
Activation of RAS in B cells R-HSA-1169092 7.868387e-01 0.104 0 0
Fructose biosynthesis R-HSA-5652227 7.868387e-01 0.104 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.868387e-01 0.104 0 0
Nucleotide salvage defects R-HSA-9734207 7.868387e-01 0.104 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.868387e-01 0.104 0 0
Sodium/Proton exchangers R-HSA-425986 7.868387e-01 0.104 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.879333e-01 0.104 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.879333e-01 0.104 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.879333e-01 0.104 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.891052e-01 0.103 0 0
Ion transport by P-type ATPases R-HSA-936837 7.904708e-01 0.102 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.916711e-01 0.101 1 1
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.916711e-01 0.101 0 0
Deadenylation of mRNA R-HSA-429947 7.918938e-01 0.101 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.918938e-01 0.101 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.918938e-01 0.101 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.928622e-01 0.101 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.934368e-01 0.100 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.934368e-01 0.100 0 0
Translesion synthesis by POLK R-HSA-5655862 7.934368e-01 0.100 0 0
Galactose catabolism R-HSA-70370 7.934368e-01 0.100 0 0
Disorders of Developmental Biology R-HSA-9675151 7.934368e-01 0.100 0 0
Synthesis of PG R-HSA-1483148 7.934368e-01 0.100 0 0
Cell junction organization R-HSA-446728 7.964676e-01 0.099 0 0
GPER1 signaling R-HSA-9634597 7.966935e-01 0.099 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.026212e-01 0.095 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.096703e-01 0.092 0 0
TGFBR3 expression R-HSA-9839394 8.096703e-01 0.092 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.117559e-01 0.091 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.141478e-01 0.089 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.141478e-01 0.089 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.141478e-01 0.089 0 0
Gap junction degradation R-HSA-190873 8.147922e-01 0.089 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.147922e-01 0.089 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.147922e-01 0.089 0 0
mRNA Editing R-HSA-75072 8.147922e-01 0.089 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.147922e-01 0.089 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.147922e-01 0.089 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.147922e-01 0.089 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.164921e-01 0.088 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.164921e-01 0.088 0 0
HIV Transcription Initiation R-HSA-167161 8.164921e-01 0.088 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.164921e-01 0.088 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.173648e-01 0.088 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.220325e-01 0.085 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.261457e-01 0.083 0 0
Mitophagy R-HSA-5205647 8.263435e-01 0.083 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.263435e-01 0.083 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.263435e-01 0.083 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.263435e-01 0.083 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.272036e-01 0.082 0 0
Vesicle-mediated transport R-HSA-5653656 8.278025e-01 0.082 1 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.287408e-01 0.082 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.329809e-01 0.079 0 0
GAB1 signalosome R-HSA-180292 8.329809e-01 0.079 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.329809e-01 0.079 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.329809e-01 0.079 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 8.329809e-01 0.079 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.329809e-01 0.079 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.359260e-01 0.078 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.359260e-01 0.078 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.359260e-01 0.078 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.390814e-01 0.076 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.390814e-01 0.076 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.390814e-01 0.076 0 0
Pexophagy R-HSA-9664873 8.390814e-01 0.076 0 0
2-LTR circle formation R-HSA-164843 8.390814e-01 0.076 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.390814e-01 0.076 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.390814e-01 0.076 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.390814e-01 0.076 0 0
Interleukin-27 signaling R-HSA-9020956 8.390814e-01 0.076 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.390814e-01 0.076 0 0
Sperm Motility And Taxes R-HSA-1300642 8.390814e-01 0.076 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.390814e-01 0.076 0 0
Packaging Of Telomere Ends R-HSA-171306 8.413841e-01 0.075 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.413841e-01 0.075 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.413841e-01 0.075 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.413841e-01 0.075 0 0
Developmental Cell Lineages R-HSA-9734767 8.417458e-01 0.075 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.418773e-01 0.075 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.425392e-01 0.074 0 0
Pyrimidine biosynthesis R-HSA-500753 8.500722e-01 0.071 0 0
Regulation of signaling by CBL R-HSA-912631 8.500722e-01 0.071 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.500722e-01 0.071 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.500722e-01 0.071 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.527063e-01 0.069 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.527063e-01 0.069 0 0
RNA Polymerase III Transcription R-HSA-74158 8.527063e-01 0.069 0 0
DAP12 interactions R-HSA-2172127 8.534437e-01 0.069 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.554518e-01 0.068 0 0
Pyroptosis R-HSA-5620971 8.554518e-01 0.068 0 0
Ub-specific processing proteases R-HSA-5689880 8.566896e-01 0.067 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.566896e-01 0.067 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.566896e-01 0.067 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.585481e-01 0.066 0 0
Signaling by PDGF R-HSA-186797 8.595303e-01 0.066 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.601864e-01 0.065 0 0
vRNA Synthesis R-HSA-192814 8.601864e-01 0.065 0 0
vRNP Assembly R-HSA-192905 8.601864e-01 0.065 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.601864e-01 0.065 0 0
Transport of RCbl within the body R-HSA-9758890 8.601864e-01 0.065 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.601864e-01 0.065 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.601864e-01 0.065 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.601864e-01 0.065 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.601864e-01 0.065 0 0
Mitochondrial protein degradation R-HSA-9837999 8.620793e-01 0.064 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.636016e-01 0.064 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.636016e-01 0.064 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.642966e-01 0.063 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.642966e-01 0.063 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.642966e-01 0.063 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.645622e-01 0.063 0 0
Cleavage of the damaged purine R-HSA-110331 8.645622e-01 0.063 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.655547e-01 0.063 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.655547e-01 0.063 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.655547e-01 0.063 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.655547e-01 0.063 0 0
Pregnenolone biosynthesis R-HSA-196108 8.655547e-01 0.063 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.655547e-01 0.063 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.657711e-01 0.063 0 0
Signaling by MET R-HSA-6806834 8.679481e-01 0.062 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.682190e-01 0.061 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.684153e-01 0.061 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.684153e-01 0.061 0 0
TCR signaling R-HSA-202403 8.727001e-01 0.059 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.744650e-01 0.058 0 0
HDACs deacetylate histones R-HSA-3214815 8.753589e-01 0.058 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.753589e-01 0.058 0 0
Adipogenesis R-HSA-9843745 8.754875e-01 0.058 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.755899e-01 0.058 0 0
Depurination R-HSA-73927 8.755899e-01 0.058 0 0
MET promotes cell motility R-HSA-8875878 8.755899e-01 0.058 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.785245e-01 0.056 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.785245e-01 0.056 0 0
Plasmalogen biosynthesis R-HSA-75896 8.785245e-01 0.056 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.785245e-01 0.056 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.785245e-01 0.056 0 0
Integration of provirus R-HSA-162592 8.785245e-01 0.056 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.795563e-01 0.056 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.795563e-01 0.056 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.795563e-01 0.056 0 0
Activation of the pre-replicative complex R-HSA-68962 8.803412e-01 0.055 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.803412e-01 0.055 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.803412e-01 0.055 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.803412e-01 0.055 0 0
rRNA processing R-HSA-72312 8.811936e-01 0.055 0 0
Signaling by NOTCH R-HSA-157118 8.817445e-01 0.055 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.834076e-01 0.054 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.839788e-01 0.054 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.841927e-01 0.053 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.858317e-01 0.053 0 0
Pentose phosphate pathway R-HSA-71336 8.858317e-01 0.053 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.858317e-01 0.053 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.878206e-01 0.052 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.878206e-01 0.052 0 0
Selenoamino acid metabolism R-HSA-2408522 8.897041e-01 0.051 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.899592e-01 0.051 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.899592e-01 0.051 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.905607e-01 0.050 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.912950e-01 0.050 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.912950e-01 0.050 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.912950e-01 0.050 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.917902e-01 0.050 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.921990e-01 0.050 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.921990e-01 0.050 0 0
Glutathione synthesis and recycling R-HSA-174403 8.921990e-01 0.050 0 0
Gluconeogenesis R-HSA-70263 8.928681e-01 0.049 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.944583e-01 0.048 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.944583e-01 0.048 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.944583e-01 0.048 0 0
Interleukin-35 Signalling R-HSA-8984722 8.944583e-01 0.048 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.944583e-01 0.048 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.944583e-01 0.048 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.944583e-01 0.048 0 0
Pervasive developmental disorders R-HSA-9005895 8.944583e-01 0.048 0 0
Disorders of Nervous System Development R-HSA-9697154 8.944583e-01 0.048 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.944583e-01 0.048 0 0
Estrogen biosynthesis R-HSA-193144 8.944583e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.944583e-01 0.048 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.953298e-01 0.048 0 0
Glycogen metabolism R-HSA-8982491 8.953298e-01 0.048 0 0
Interferon Signaling R-HSA-913531 8.956237e-01 0.048 0 0
Cellular response to chemical stress R-HSA-9711123 8.997179e-01 0.046 1 0
Dual incision in TC-NER R-HSA-6782135 9.002770e-01 0.046 0 0
DNA Damage Bypass R-HSA-73893 9.011629e-01 0.045 0 0
GPCR downstream signalling R-HSA-388396 9.012655e-01 0.045 0 0
DNA strand elongation R-HSA-69190 9.013408e-01 0.045 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.019605e-01 0.045 0 0
Fructose metabolism R-HSA-5652084 9.035984e-01 0.044 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.035984e-01 0.044 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.037762e-01 0.044 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.041258e-01 0.044 0 0
Gene Silencing by RNA R-HSA-211000 9.055490e-01 0.043 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.064181e-01 0.043 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.064181e-01 0.043 0 0
Toll-like Receptor Cascades R-HSA-168898 9.068980e-01 0.042 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.075675e-01 0.042 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.083028e-01 0.042 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.083028e-01 0.042 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.083028e-01 0.042 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.083028e-01 0.042 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.083028e-01 0.042 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.083028e-01 0.042 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.083028e-01 0.042 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.083028e-01 0.042 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.083028e-01 0.042 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.083028e-01 0.042 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.083028e-01 0.042 0 0
Translation of Structural Proteins R-HSA-9694635 9.084266e-01 0.042 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.088933e-01 0.041 0 0
Neutrophil degranulation R-HSA-6798695 9.090627e-01 0.041 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.102684e-01 0.041 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.105406e-01 0.041 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.105406e-01 0.041 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.105406e-01 0.041 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.122607e-01 0.040 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.122607e-01 0.040 0 0
G alpha (q) signalling events R-HSA-416476 9.138370e-01 0.039 0 0
Interleukin-20 family signaling R-HSA-8854691 9.138629e-01 0.039 0 0
GABA receptor activation R-HSA-977443 9.144039e-01 0.039 0 0
RAB geranylgeranylation R-HSA-8873719 9.144039e-01 0.039 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.144039e-01 0.039 0 0
RNA Polymerase I Transcription R-HSA-73864 9.145261e-01 0.039 0 0
PCP/CE pathway R-HSA-4086400 9.145261e-01 0.039 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.160889e-01 0.038 0 0
Collagen formation R-HSA-1474290 9.171284e-01 0.038 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.189136e-01 0.037 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.189543e-01 0.037 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.189543e-01 0.037 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.197747e-01 0.036 0 0
Depyrimidination R-HSA-73928 9.197747e-01 0.036 0 0
Removal of the Flap Intermediate R-HSA-69166 9.203320e-01 0.036 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.203320e-01 0.036 0 0
Transport of fatty acids R-HSA-804914 9.203320e-01 0.036 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.203320e-01 0.036 0 0
Hydrolysis of LPC R-HSA-1483115 9.203320e-01 0.036 0 0
Signal regulatory protein family interactions R-HSA-391160 9.203320e-01 0.036 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.203320e-01 0.036 0 0
Physiological factors R-HSA-5578768 9.203320e-01 0.036 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.203320e-01 0.036 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.203320e-01 0.036 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.203320e-01 0.036 0 0
HDL assembly R-HSA-8963896 9.203320e-01 0.036 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.203320e-01 0.036 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.207906e-01 0.036 0 0
MAP kinase activation R-HSA-450294 9.207906e-01 0.036 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.227788e-01 0.035 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.227788e-01 0.035 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.230942e-01 0.035 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.230942e-01 0.035 0 0
Interleukin-6 family signaling R-HSA-6783589 9.230942e-01 0.035 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.230942e-01 0.035 0 0
G alpha (s) signalling events R-HSA-418555 9.246000e-01 0.034 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.256864e-01 0.034 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.257840e-01 0.033 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.266390e-01 0.033 0 0
eNOS activation R-HSA-203615 9.266390e-01 0.033 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.266390e-01 0.033 0 0
Defective pyroptosis R-HSA-9710421 9.267064e-01 0.033 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.267561e-01 0.033 0 0
Mitochondrial protein import R-HSA-1268020 9.267561e-01 0.033 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.267561e-01 0.033 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.282355e-01 0.032 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.289915e-01 0.032 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.289915e-01 0.032 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.289915e-01 0.032 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.307837e-01 0.031 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.307837e-01 0.031 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.307837e-01 0.031 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.307837e-01 0.031 0 0
Biotin transport and metabolism R-HSA-196780 9.307837e-01 0.031 0 0
Other semaphorin interactions R-HSA-416700 9.307837e-01 0.031 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.307837e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.307837e-01 0.031 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.313866e-01 0.031 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.313866e-01 0.031 0 0
G protein gated Potassium channels R-HSA-1296059 9.313866e-01 0.031 0 0
Laminin interactions R-HSA-3000157 9.313866e-01 0.031 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.317663e-01 0.031 0 0
Surfactant metabolism R-HSA-5683826 9.330935e-01 0.030 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.336494e-01 0.030 0 0
Oncogene Induced Senescence R-HSA-2559585 9.336494e-01 0.030 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.347547e-01 0.029 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.350682e-01 0.029 0 0
Base Excision Repair R-HSA-73884 9.356200e-01 0.029 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.388275e-01 0.027 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.389720e-01 0.027 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.389720e-01 0.027 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.398648e-01 0.027 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.398648e-01 0.027 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.398648e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.398648e-01 0.027 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.398648e-01 0.027 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.398648e-01 0.027 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.398648e-01 0.027 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.398648e-01 0.027 0 0
Fructose catabolism R-HSA-70350 9.398648e-01 0.027 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.398648e-01 0.027 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.398648e-01 0.027 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.398648e-01 0.027 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.398648e-01 0.027 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.400371e-01 0.027 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.400371e-01 0.027 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.400371e-01 0.027 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.400951e-01 0.027 0 0
G alpha (z) signalling events R-HSA-418597 9.400951e-01 0.027 0 0
Signaling by NOTCH4 R-HSA-9013694 9.407862e-01 0.027 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.442682e-01 0.025 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.443765e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.443765e-01 0.025 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.453136e-01 0.024 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.454976e-01 0.024 0 0
Cristae formation R-HSA-8949613 9.454976e-01 0.024 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.454976e-01 0.024 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.477550e-01 0.023 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.477550e-01 0.023 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.477550e-01 0.023 0 0
Coenzyme A biosynthesis R-HSA-196783 9.477550e-01 0.023 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.477550e-01 0.023 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.477550e-01 0.023 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.477805e-01 0.023 0 0
Hemostasis R-HSA-109582 9.478314e-01 0.023 0 0
UCH proteinases R-HSA-5689603 9.492322e-01 0.023 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.493399e-01 0.023 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.504043e-01 0.022 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.509253e-01 0.022 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.514710e-01 0.022 0 0
Pyrimidine salvage R-HSA-73614 9.514710e-01 0.022 0 0
SARS-CoV Infections R-HSA-9679506 9.519356e-01 0.021 0 0
Intraflagellar transport R-HSA-5620924 9.538937e-01 0.021 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.538937e-01 0.021 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.543300e-01 0.020 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.546102e-01 0.020 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.546102e-01 0.020 0 0
Catecholamine biosynthesis R-HSA-209905 9.546102e-01 0.020 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.546102e-01 0.020 0 0
Stabilization of p53 R-HSA-69541 9.559376e-01 0.020 0 0
RAS processing R-HSA-9648002 9.559376e-01 0.020 0 0
mRNA Capping R-HSA-72086 9.568156e-01 0.019 0 0
DNA methylation R-HSA-5334118 9.568156e-01 0.019 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.568156e-01 0.019 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.568156e-01 0.019 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.568156e-01 0.019 0 0
Glucagon-type ligand receptors R-HSA-420092 9.568156e-01 0.019 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.585622e-01 0.018 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.586190e-01 0.018 0 0
Potential therapeutics for SARS R-HSA-9679191 9.600567e-01 0.018 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.602939e-01 0.018 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.602939e-01 0.018 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.602939e-01 0.018 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.605664e-01 0.017 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.605664e-01 0.017 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.605664e-01 0.017 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.605664e-01 0.017 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.605664e-01 0.017 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.605664e-01 0.017 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.613276e-01 0.017 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.615936e-01 0.017 0 0
Interleukin-17 signaling R-HSA-448424 9.618293e-01 0.017 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.642430e-01 0.016 0 0
Maturation of spike protein R-HSA-9694548 9.642430e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.653859e-01 0.015 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.657412e-01 0.015 0 0
Translesion Synthesis by POLH R-HSA-110320 9.657412e-01 0.015 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.657412e-01 0.015 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.657412e-01 0.015 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.657412e-01 0.015 0 0
Downstream TCR signaling R-HSA-202424 9.671040e-01 0.015 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.676889e-01 0.014 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.678197e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9683701 9.678197e-01 0.014 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.685818e-01 0.014 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.695607e-01 0.013 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.702372e-01 0.013 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.702372e-01 0.013 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.702372e-01 0.013 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.702372e-01 0.013 0 0
Signaling by NODAL R-HSA-1181150 9.702372e-01 0.013 0 0
Glycogen synthesis R-HSA-3322077 9.702372e-01 0.013 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.704234e-01 0.013 0 0
Activation of GABAB receptors R-HSA-991365 9.710565e-01 0.013 0 0
GABA B receptor activation R-HSA-977444 9.710565e-01 0.013 0 0
Adaptive Immune System R-HSA-1280218 9.729570e-01 0.012 0 0
Protein folding R-HSA-391251 9.739800e-01 0.011 0 0
G-protein activation R-HSA-202040 9.741434e-01 0.011 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.741434e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.741434e-01 0.011 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.741434e-01 0.011 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.741638e-01 0.011 0 0
Co-inhibition by PD-1 R-HSA-389948 9.744872e-01 0.011 0 0
Interleukin-1 signaling R-HSA-9020702 9.749535e-01 0.011 0 0
Cellular response to hypoxia R-HSA-1234174 9.754376e-01 0.011 0 0
Signaling by GPCR R-HSA-372790 9.755954e-01 0.011 0 0
SLC transporter disorders R-HSA-5619102 9.756559e-01 0.011 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.759622e-01 0.011 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.759622e-01 0.011 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.760979e-01 0.011 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.766273e-01 0.010 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.775372e-01 0.010 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.775372e-01 0.010 0 0
Assembly Of The HIV Virion R-HSA-175474 9.775372e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.775372e-01 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.776094e-01 0.010 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.787957e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.787957e-01 0.009 0 0
Signal amplification R-HSA-392518 9.787957e-01 0.009 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.787957e-01 0.009 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.788044e-01 0.009 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.788044e-01 0.009 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.790144e-01 0.009 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.790144e-01 0.009 0 0
Interleukin-1 family signaling R-HSA-446652 9.795517e-01 0.009 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.796008e-01 0.009 0 0
HCMV Early Events R-HSA-9609690 9.804784e-01 0.009 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.804856e-01 0.009 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.804856e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.804856e-01 0.009 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.804856e-01 0.009 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.804856e-01 0.009 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.804856e-01 0.009 0 0
Cellular hexose transport R-HSA-189200 9.804856e-01 0.009 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.804856e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.808185e-01 0.008 0 0
Protein localization R-HSA-9609507 9.808393e-01 0.008 0 0
Integrin cell surface interactions R-HSA-216083 9.808900e-01 0.008 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.811679e-01 0.008 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.825173e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.826507e-01 0.008 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.830472e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.830472e-01 0.007 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.830472e-01 0.007 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.830472e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.830472e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.830472e-01 0.007 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.830472e-01 0.007 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.830472e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.830472e-01 0.007 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.830472e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.831092e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.831964e-01 0.007 0 0
PKR-mediated signaling R-HSA-9833482 9.840144e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.843163e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.843163e-01 0.007 0 0
Cell-cell junction organization R-HSA-421270 9.844605e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.851602e-01 0.006 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.852338e-01 0.006 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.852338e-01 0.006 0 0
Degradation of AXIN R-HSA-4641257 9.852338e-01 0.006 0 0
Degradation of DVL R-HSA-4641258 9.852338e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.852338e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.852338e-01 0.006 0 0
CYP2E1 reactions R-HSA-211999 9.852727e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.852727e-01 0.006 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.852727e-01 0.006 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.852727e-01 0.006 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.852727e-01 0.006 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.852727e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.852727e-01 0.006 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.852727e-01 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.852864e-01 0.006 0 0
Amyloid fiber formation R-HSA-977225 9.853908e-01 0.006 0 0
Synthesis of DNA R-HSA-69239 9.854774e-01 0.006 0 0
Adherens junctions interactions R-HSA-418990 9.858574e-01 0.006 0 0
Degradation of CDH1 R-HSA-9766229 9.864325e-01 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.864325e-01 0.006 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.866174e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.871362e-01 0.006 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.872030e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.872030e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.872061e-01 0.006 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.872061e-01 0.006 0 0
Fertilization R-HSA-1187000 9.872061e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.872061e-01 0.006 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.876243e-01 0.005 0 0
Urea cycle R-HSA-70635 9.888858e-01 0.005 0 0
Sphingolipid catabolism R-HSA-9845614 9.888858e-01 0.005 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.888858e-01 0.005 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.888858e-01 0.005 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.891228e-01 0.005 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.897534e-01 0.004 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.897534e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.897534e-01 0.004 0 0
Orc1 removal from chromatin R-HSA-68949 9.902674e-01 0.004 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.903451e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.903451e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.903451e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.903451e-01 0.004 0 0
Protein ubiquitination R-HSA-8852135 9.904997e-01 0.004 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.904997e-01 0.004 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.904997e-01 0.004 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.907553e-01 0.004 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.909349e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.909349e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.912953e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.916128e-01 0.004 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.919829e-01 0.003 0 0
HCMV Late Events R-HSA-9610379 9.922500e-01 0.003 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.927009e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.927142e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.929121e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.929238e-01 0.003 0 0
Nicotinate metabolism R-HSA-196807 9.931284e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.935869e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.935869e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.936710e-01 0.003 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.937355e-01 0.003 0 0
tRNA processing R-HSA-72306 9.944285e-01 0.002 0 0
Regulation of CDH1 Function R-HSA-9764561 9.944532e-01 0.002 0 0
Gap junction trafficking R-HSA-190828 9.944650e-01 0.002 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.945021e-01 0.002 0 0
Cargo concentration in the ER R-HSA-5694530 9.945021e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.945021e-01 0.002 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.949946e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.949946e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.949946e-01 0.002 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.951109e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.951109e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.952242e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.955001e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.955001e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.956582e-01 0.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.957068e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.958515e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.960594e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.960600e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.961265e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.961887e-01 0.002 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.962689e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.963964e-01 0.002 0 0
Heme degradation R-HSA-189483 9.963964e-01 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 9.964871e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.964871e-01 0.002 0 0
RSV-host interactions R-HSA-9833110 9.967796e-01 0.001 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.968698e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.968698e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.968698e-01 0.001 0 0
Gap junction trafficking and regulation R-HSA-157858 9.970321e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.970321e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.970802e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.971424e-01 0.001 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.972810e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.972810e-01 0.001 0 0
Regulation of Apoptosis R-HSA-169911 9.972810e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.972810e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.973123e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.973123e-01 0.001 0 0
DNA Replication R-HSA-69306 9.976025e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.976382e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.976382e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.979485e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.979485e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.979485e-01 0.001 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.979643e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.981227e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.982008e-01 0.001 0 0
Purine salvage R-HSA-74217 9.982180e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.982474e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.984409e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.984522e-01 0.001 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.984522e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.984522e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.986067e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.986556e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.988322e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.988322e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.988721e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.989857e-01 0.000 0 0
Immune System R-HSA-168256 9.990282e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.991190e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.991463e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992318e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.992348e-01 0.000 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.992348e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.992624e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.992624e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.993023e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.993354e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.993354e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.993424e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.993886e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994093e-01 0.000 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.994227e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.994430e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.994680e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.994680e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.994680e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.994975e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.995025e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.995232e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996218e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.996487e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997147e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997147e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997151e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997359e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.997489e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997522e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.997522e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997692e-01 0.000 0 0
Neddylation R-HSA-8951664 9.997871e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.998010e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998208e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998405e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.998426e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998426e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998431e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998431e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998629e-01 0.000 0 0
Digestion R-HSA-8935690 9.998776e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.998937e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999198e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999279e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999304e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999367e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999395e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999544e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999593e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999604e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999604e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999604e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999632e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999632e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999654e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999656e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999684e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999706e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999712e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999736e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999741e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999790e-01 0.000 0 0
Translation R-HSA-72766 9.999822e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999830e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999846e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999853e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999853e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999889e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999889e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999903e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999936e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999945e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999949e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999956e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999964e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999964e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999973e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999976e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999988e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999989e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999990e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999995e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999995e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999999e-01 0.000 0 0
Disease R-HSA-1643685 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 1 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 3.280964e-11 10.484 0 0
HSF1-dependent transactivation R-HSA-3371571 1.827872e-10 9.738 0 0
Cellular response to heat stress R-HSA-3371556 2.704225e-10 9.568 0 0
Apoptotic execution phase R-HSA-75153 5.967754e-10 9.224 0 0
HSF1 activation R-HSA-3371511 2.026363e-08 7.693 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.915595e-08 7.718 0 0
Cellular responses to stress R-HSA-2262752 5.582097e-08 7.253 1 0
Cellular responses to stimuli R-HSA-8953897 1.725035e-07 6.763 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.407087e-06 5.852 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.288251e-06 5.137 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.438427e-06 5.025 0 0
Axon guidance R-HSA-422475 8.488050e-05 4.071 0 0
FLT3 Signaling R-HSA-9607240 9.417622e-05 4.026 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.032702e-04 3.986 0 0
Apoptosis R-HSA-109581 1.013842e-04 3.994 0 0
Nervous system development R-HSA-9675108 1.237753e-04 3.907 0 0
Neurodegenerative Diseases R-HSA-8863678 1.344428e-04 3.871 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.344428e-04 3.871 0 0
Membrane Trafficking R-HSA-199991 1.555590e-04 3.808 1 0
ChREBP activates metabolic gene expression R-HSA-163765 1.701765e-04 3.769 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.874216e-04 3.727 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.264620e-04 3.645 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.706099e-04 3.568 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.160042e-04 3.500 0 0
Programmed Cell Death R-HSA-5357801 3.069935e-04 3.513 0 0
Cellular Senescence R-HSA-2559583 3.556689e-04 3.449 0 0
Cell-Cell communication R-HSA-1500931 4.098690e-04 3.387 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.447936e-04 3.073 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.279324e-04 3.082 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.037316e-03 2.984 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.037316e-03 2.984 0 0
HIV Life Cycle R-HSA-162587 9.424113e-04 3.026 0 0
Signal Transduction R-HSA-162582 1.014256e-03 2.994 1 0
Interleukin-12 signaling R-HSA-9020591 1.046448e-03 2.980 0 0
HIV Infection R-HSA-162906 1.062174e-03 2.974 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.215202e-03 2.915 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.243946e-03 2.905 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.318772e-03 2.880 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.354208e-03 2.868 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.376330e-03 2.861 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.440745e-03 2.841 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.414630e-03 2.849 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.623900e-03 2.789 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.623615e-03 2.790 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.703538e-03 2.769 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.786739e-03 2.748 0 0
Cell junction organization R-HSA-446728 1.750321e-03 2.757 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.870090e-03 2.728 0 0
Cell Cycle R-HSA-1640170 1.816718e-03 2.741 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.146636e-03 2.668 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.034677e-03 2.692 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.173724e-03 2.663 0 0
Influenza Infection R-HSA-168255 2.064125e-03 2.685 0 0
Interleukin-12 family signaling R-HSA-447115 2.186170e-03 2.660 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.303642e-03 2.638 0 0
Signaling by ROBO receptors R-HSA-376176 2.488282e-03 2.604 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.564106e-03 2.591 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.157770e-03 2.501 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.139382e-03 2.503 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.754796e-03 2.560 0 0
MAP2K and MAPK activation R-HSA-5674135 3.045789e-03 2.516 0 0
CREB phosphorylation R-HSA-199920 3.157770e-03 2.501 0 0
Cell Cycle, Mitotic R-HSA-69278 2.904524e-03 2.537 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.443890e-03 2.463 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.443890e-03 2.463 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.516713e-03 2.454 0 0
Translation initiation complex formation R-HSA-72649 3.598559e-03 2.444 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.003882e-03 2.398 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.003882e-03 2.398 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.301072e-03 2.366 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.326748e-03 2.364 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.776186e-03 2.321 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.674656e-03 2.330 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.674656e-03 2.330 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.004898e-03 2.301 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.902933e-03 2.310 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.923538e-03 2.308 0 0
Chromatin modifying enzymes R-HSA-3247509 4.936848e-03 2.307 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.773089e-03 2.321 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.246534e-03 2.280 0 0
Signaling by PTK6 R-HSA-8848021 5.246534e-03 2.280 0 0
Late endosomal microautophagy R-HSA-9615710 5.328944e-03 2.273 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.103326e-03 2.214 0 0
Signaling by VEGF R-HSA-194138 6.127034e-03 2.213 0 0
Signaling by ALK in cancer R-HSA-9700206 6.103326e-03 2.214 0 0
Cellular response to starvation R-HSA-9711097 6.221046e-03 2.206 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.248872e-03 2.204 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.359155e-03 2.197 0 0
Signaling by RAS mutants R-HSA-6802949 6.677303e-03 2.175 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.677303e-03 2.175 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.677303e-03 2.175 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.677303e-03 2.175 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.677303e-03 2.175 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.693907e-03 2.174 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.922985e-03 2.160 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.329098e-03 2.135 0 0
Type I hemidesmosome assembly R-HSA-446107 7.240373e-03 2.140 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.457281e-03 2.127 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.143346e-03 2.146 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.703906e-03 2.113 0 0
Chromatin organization R-HSA-4839726 7.821550e-03 2.107 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.871386e-03 2.104 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.902370e-03 2.102 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.941149e-03 2.100 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.976566e-03 2.098 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.357559e-03 2.078 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.357559e-03 2.078 0 0
Signaling by NTRKs R-HSA-166520 8.790492e-03 2.056 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.589788e-03 2.018 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.589788e-03 2.018 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.589788e-03 2.018 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.589788e-03 2.018 0 0
Autophagy R-HSA-9612973 9.247396e-03 2.034 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.026111e-02 1.989 0 0
Peptide chain elongation R-HSA-156902 1.043610e-02 1.981 0 0
Diseases of programmed cell death R-HSA-9645723 1.043610e-02 1.981 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.046004e-02 1.980 0 0
Signaling by Hippo R-HSA-2028269 1.065228e-02 1.973 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.150413e-02 1.939 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.100623e-02 1.958 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.155512e-02 1.937 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.188296e-02 1.925 0 0
NRAGE signals death through JNK R-HSA-193648 1.093542e-02 1.961 0 0
Notch-HLH transcription pathway R-HSA-350054 1.196768e-02 1.922 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.201605e-02 1.920 0 0
Regulation of CDH1 Function R-HSA-9764561 1.234893e-02 1.908 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.234893e-02 1.908 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.329025e-02 1.876 0 0
Ephrin signaling R-HSA-3928664 1.329025e-02 1.876 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.488850e-02 1.827 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.481389e-02 1.829 0 0
MAPK family signaling cascades R-HSA-5683057 1.462823e-02 1.835 0 0
S Phase R-HSA-69242 1.500528e-02 1.824 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.524677e-02 1.817 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.636654e-02 1.786 0 0
Nef and signal transduction R-HSA-164944 1.696099e-02 1.771 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.732442e-02 1.761 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.749938e-02 1.757 0 0
FOXO-mediated transcription R-HSA-9614085 1.803863e-02 1.744 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.778166e-02 1.750 0 0
HATs acetylate histones R-HSA-3214847 1.803863e-02 1.744 0 0
Cell Cycle Checkpoints R-HSA-69620 1.968597e-02 1.706 0 0
FLT3 signaling in disease R-HSA-9682385 1.981219e-02 1.703 0 0
mRNA Splicing R-HSA-72172 2.036709e-02 1.691 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.042887e-02 1.690 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.042887e-02 1.690 0 0
Selenocysteine synthesis R-HSA-2408557 2.129896e-02 1.672 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.151619e-02 1.667 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.380251e-02 1.623 0 0
SOS-mediated signalling R-HSA-112412 2.380251e-02 1.623 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.420727e-02 1.616 0 0
Activation of RAC1 R-HSA-428540 2.420727e-02 1.616 0 0
Negative regulation of FLT3 R-HSA-9706369 2.241221e-02 1.650 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.272866e-02 1.643 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.272866e-02 1.643 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.352501e-02 1.628 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.312243e-02 1.636 1 1
G0 and Early G1 R-HSA-1538133 2.369616e-02 1.625 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.272267e-02 1.644 0 0
Semaphorin interactions R-HSA-373755 2.401429e-02 1.620 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.424498e-02 1.615 0 0
M Phase R-HSA-68886 2.441642e-02 1.612 0 0
Vesicle-mediated transport R-HSA-5653656 2.457801e-02 1.609 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.538172e-02 1.595 1 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.594375e-02 1.586 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.598969e-02 1.585 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.619104e-02 1.582 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.731951e-02 1.564 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.749208e-02 1.561 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.768202e-02 1.558 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.768202e-02 1.558 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.768202e-02 1.558 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.830004e-02 1.548 0 0
Adherens junctions interactions R-HSA-418990 2.852004e-02 1.545 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.871900e-02 1.542 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.871900e-02 1.542 0 0
RSK activation R-HSA-444257 3.209903e-02 1.494 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.069540e-02 1.513 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.131607e-02 1.504 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.947196e-02 1.531 0 0
Ribosome-associated quality control R-HSA-9948299 3.244223e-02 1.489 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.131607e-02 1.504 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.332695e-02 1.477 0 0
Metabolism of RNA R-HSA-8953854 3.226869e-02 1.491 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.332695e-02 1.477 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.131607e-02 1.504 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.929871e-02 1.533 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.333762e-02 1.477 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.333762e-02 1.477 0 0
Specification of primordial germ cells R-HSA-9827857 3.333762e-02 1.477 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.369992e-02 1.472 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.485523e-02 1.458 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.508864e-02 1.455 0 0
Smooth Muscle Contraction R-HSA-445355 3.525666e-02 1.453 0 0
Nuclear import of Rev protein R-HSA-180746 3.570172e-02 1.447 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.752148e-02 1.426 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.752148e-02 1.426 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.068201e-02 1.391 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.068201e-02 1.391 0 0
Lipophagy R-HSA-9613354 4.188940e-02 1.378 1 1
Gap junction degradation R-HSA-190873 4.188940e-02 1.378 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.783904e-02 1.422 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.333097e-02 1.363 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.333097e-02 1.363 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.049089e-02 1.393 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.867951e-02 1.413 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.905162e-02 1.408 0 0
Transcription of the HIV genome R-HSA-167172 3.879398e-02 1.411 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.354138e-02 1.361 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.289336e-02 1.368 0 0
Polo-like kinase mediated events R-HSA-156711 3.990009e-02 1.399 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.196083e-02 1.377 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.188940e-02 1.378 0 0
Eukaryotic Translation Termination R-HSA-72764 4.168094e-02 1.380 0 0
G2/M Transition R-HSA-69275 3.972639e-02 1.401 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.817952e-02 1.418 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.408068e-02 1.356 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.827570e-02 1.417 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.990009e-02 1.399 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.575565e-02 1.340 0 0
Deadenylation of mRNA R-HSA-429947 4.575565e-02 1.340 0 0
L1CAM interactions R-HSA-373760 4.603976e-02 1.337 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.668654e-02 1.331 0 0
Host Interactions of HIV factors R-HSA-162909 4.711040e-02 1.327 0 0
Signaling by EGFR R-HSA-177929 4.742348e-02 1.324 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.774017e-02 1.321 0 0
G alpha (12/13) signalling events R-HSA-416482 4.907565e-02 1.309 0 0
Budding and maturation of HIV virion R-HSA-162588 4.932399e-02 1.307 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.996534e-02 1.301 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.114646e-02 1.291 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.114646e-02 1.291 0 0
TBC/RABGAPs R-HSA-8854214 5.225362e-02 1.282 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.318303e-02 1.274 0 0
Signaling by Leptin R-HSA-2586552 5.318303e-02 1.274 0 0
Circadian clock R-HSA-9909396 5.409434e-02 1.267 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.423020e-02 1.192 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.423020e-02 1.192 0 0
Integrin signaling R-HSA-354192 6.285627e-02 1.202 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.285627e-02 1.202 0 0
mRNA 3'-end processing R-HSA-72187 6.331040e-02 1.199 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.697343e-02 1.244 0 0
Cell-cell junction organization R-HSA-421270 6.260707e-02 1.203 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.027017e-02 1.220 0 0
ERK/MAPK targets R-HSA-198753 6.423020e-02 1.192 0 0
Neurexins and neuroligins R-HSA-6794361 6.331040e-02 1.199 0 0
Mitotic Prophase R-HSA-68875 5.915541e-02 1.228 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.524615e-02 1.185 0 0
Post NMDA receptor activation events R-HSA-438064 5.969516e-02 1.224 1 0
Death Receptor Signaling R-HSA-73887 5.572557e-02 1.254 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.572557e-02 1.254 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.913405e-02 1.228 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.596252e-02 1.181 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.681390e-02 1.175 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.681390e-02 1.175 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.681390e-02 1.175 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.773187e-02 1.169 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.898431e-02 1.161 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.960823e-02 1.157 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.039034e-02 1.152 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.087855e-02 1.149 0 0
Viral mRNA Translation R-HSA-192823 7.192942e-02 1.143 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.210261e-02 1.142 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.355156e-02 1.133 0 0
MAP kinase activation R-HSA-450294 7.357558e-02 1.133 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.391644e-02 1.131 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.391644e-02 1.131 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.391644e-02 1.131 0 0
Assembly Of The HIV Virion R-HSA-175474 7.391644e-02 1.131 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.416430e-02 1.130 0 0
PTK6 Expression R-HSA-8849473 9.429069e-02 1.026 0 0
Recycling of eIF2:GDP R-HSA-72731 9.429069e-02 1.026 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.429069e-02 1.026 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.429069e-02 1.026 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.104744e-02 1.041 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.616934e-02 1.065 0 0
HIV Transcription Initiation R-HSA-167161 8.616934e-02 1.065 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.616934e-02 1.065 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.620694e-02 1.064 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.620694e-02 1.064 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.710950e-02 1.060 0 0
Co-inhibition by PD-1 R-HSA-389948 7.787591e-02 1.109 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.988601e-02 1.098 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.651675e-02 1.116 0 0
Separation of Sister Chromatids R-HSA-2467813 9.168994e-02 1.038 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.018690e-02 1.096 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.620694e-02 1.064 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.973325e-02 1.098 0 0
Cellular response to chemical stress R-HSA-9711123 8.804167e-02 1.055 1 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.207169e-02 1.036 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.207169e-02 1.036 0 0
G1/S Transition R-HSA-69206 8.339936e-02 1.079 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.668286e-02 1.115 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.210540e-02 1.086 0 0
Mitotic Prometaphase R-HSA-68877 8.188175e-02 1.087 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.653778e-02 1.116 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.829645e-02 1.106 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.925086e-02 1.049 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.018690e-02 1.096 0 0
Regulation of TP53 Activity R-HSA-5633007 7.582350e-02 1.120 1 0
Signaling by Interleukins R-HSA-449147 8.842714e-02 1.053 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.842639e-02 1.106 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.324654e-02 1.030 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.438851e-02 1.074 0 0
MTOR signalling R-HSA-165159 9.449670e-02 1.025 1 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 9.579483e-02 1.019 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.579483e-02 1.019 0 0
RET signaling R-HSA-8853659 9.625270e-02 1.017 0 0
G1/S-Specific Transcription R-HSA-69205 9.625270e-02 1.017 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.689093e-02 1.014 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.689093e-02 1.014 1 1
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.690491e-02 1.014 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.754695e-02 1.011 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.762724e-02 1.010 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.000934e-01 1.000 0 0
MET activates PTPN11 R-HSA-8865999 1.015572e-01 0.993 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.018109e-01 0.992 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.018109e-01 0.992 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.018109e-01 0.992 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.018109e-01 0.992 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.018109e-01 0.992 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.018109e-01 0.992 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.018109e-01 0.992 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.018109e-01 0.992 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.018109e-01 0.992 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.018109e-01 0.992 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.018109e-01 0.992 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.018109e-01 0.992 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.018109e-01 0.992 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.018109e-01 0.992 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.018109e-01 0.992 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.018109e-01 0.992 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.018109e-01 0.992 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.021426e-01 0.991 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.023424e-01 0.990 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.032760e-01 0.986 0 0
Signaling by SCF-KIT R-HSA-1433557 1.032760e-01 0.986 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.366464e-01 0.864 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.366464e-01 0.864 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.366464e-01 0.864 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.366464e-01 0.864 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.163770e-01 0.934 0 0
Formation of annular gap junctions R-HSA-196025 1.163770e-01 0.934 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.163770e-01 0.934 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.163770e-01 0.934 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.127080e-01 0.948 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.308344e-01 0.883 0 0
TGFBR3 expression R-HSA-9839394 1.203810e-01 0.919 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.338297e-01 0.873 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.379642e-01 0.860 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.221705e-01 0.913 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.075306e-01 0.968 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.295758e-01 0.887 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.316821e-01 0.880 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.330522e-01 0.876 0 0
Signaling by ERBB2 R-HSA-1227986 1.208178e-01 0.918 0 0
IRE1alpha activates chaperones R-HSA-381070 1.341929e-01 0.872 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.265101e-01 0.898 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.136357e-01 0.944 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.189412e-01 0.925 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.076404e-01 0.968 0 0
Developmental Cell Lineages R-HSA-9734767 1.327406e-01 0.877 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.366464e-01 0.864 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.366464e-01 0.864 0 0
Sodium/Proton exchangers R-HSA-425986 1.163770e-01 0.934 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.308344e-01 0.883 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.208178e-01 0.918 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.208178e-01 0.918 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.208178e-01 0.918 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.208178e-01 0.918 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.204678e-01 0.919 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.308344e-01 0.883 0 0
Selective autophagy R-HSA-9663891 1.062145e-01 0.974 1 0
MyD88-independent TLR4 cascade R-HSA-166166 1.142364e-01 0.942 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.338702e-01 0.873 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.142364e-01 0.942 0 0
PTEN Regulation R-HSA-6807070 1.238571e-01 0.907 0 0
Macroautophagy R-HSA-1632852 1.354583e-01 0.868 1 1
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.208178e-01 0.918 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.238571e-01 0.907 0 0
Signal regulatory protein family interactions R-HSA-391160 1.308344e-01 0.883 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.221705e-01 0.913 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.295758e-01 0.887 0 0
PI Metabolism R-HSA-1483255 1.078975e-01 0.967 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.078975e-01 0.967 1 0
Signaling by FGFR4 in disease R-HSA-5655291 1.308344e-01 0.883 0 0
Interleukin-6 signaling R-HSA-1059683 1.127080e-01 0.948 0 0
Signaling by NOTCH1 R-HSA-1980143 1.250562e-01 0.903 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.271078e-01 0.896 0 0
Muscle contraction R-HSA-397014 1.309990e-01 0.883 0 0
Regulation of KIT signaling R-HSA-1433559 1.308344e-01 0.883 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.308586e-01 0.883 0 0
Kinesins R-HSA-983189 1.208178e-01 0.918 0 0
Cytoprotection by HMOX1 R-HSA-9707564 1.187832e-01 0.925 0 0
Dopamine receptors R-HSA-390651 1.366464e-01 0.864 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.127080e-01 0.948 0 0
Heme signaling R-HSA-9707616 1.386710e-01 0.858 0 0
tRNA processing in the nucleus R-HSA-6784531 1.386710e-01 0.858 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.401765e-01 0.853 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.401765e-01 0.853 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.401765e-01 0.853 0 0
Interleukin-17 signaling R-HSA-448424 1.403463e-01 0.853 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.413251e-01 0.850 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.414641e-01 0.849 0 0
Recycling pathway of L1 R-HSA-437239 1.427937e-01 0.845 0 0
Striated Muscle Contraction R-HSA-390522 1.433451e-01 0.844 0 0
HDACs deacetylate histones R-HSA-3214815 1.460243e-01 0.836 0 0
Glycolysis R-HSA-70171 1.489681e-01 0.827 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.493090e-01 0.826 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.499313e-01 0.824 1 1
Erythropoietin activates RAS R-HSA-9027284 1.500714e-01 0.824 0 0
DCC mediated attractive signaling R-HSA-418885 1.500714e-01 0.824 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.500714e-01 0.824 0 0
Protein methylation R-HSA-8876725 1.500714e-01 0.824 0 0
Mitotic Anaphase R-HSA-68882 1.509657e-01 0.821 0 0
NGF-stimulated transcription R-HSA-9031628 1.537270e-01 0.813 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.559651e-01 0.807 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.562204e-01 0.806 0 0
TNF signaling R-HSA-75893 1.563280e-01 0.806 0 0
RAF activation R-HSA-5673000 1.563776e-01 0.806 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.563776e-01 0.806 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.585641e-01 0.800 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.585641e-01 0.800 0 0
Signaling by MET R-HSA-6806834 1.586829e-01 0.799 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.932617e-01 0.714 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.932617e-01 0.714 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.932617e-01 0.714 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.932617e-01 0.714 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.932617e-01 0.714 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.932617e-01 0.714 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.932617e-01 0.714 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.932617e-01 0.714 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.754061e-01 0.560 0 0
Intestinal infectious diseases R-HSA-8942233 2.754061e-01 0.560 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.754061e-01 0.560 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.754061e-01 0.560 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.754061e-01 0.560 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.754061e-01 0.560 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.754061e-01 0.560 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.754061e-01 0.560 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.754061e-01 0.560 0 0
Reelin signalling pathway R-HSA-8866376 1.739060e-01 0.760 0 0
IRS activation R-HSA-74713 1.739060e-01 0.760 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 1.739060e-01 0.760 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.739060e-01 0.760 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.125311e-01 0.673 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.125311e-01 0.673 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.125311e-01 0.673 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.125311e-01 0.673 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.491907e-01 0.457 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.491907e-01 0.457 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.491907e-01 0.457 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.491907e-01 0.457 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.491907e-01 0.457 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.491907e-01 0.457 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.491907e-01 0.457 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.654358e-01 0.781 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.654358e-01 0.781 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.518578e-01 0.599 0 0
STAT5 Activation R-HSA-9645135 2.518578e-01 0.599 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.518578e-01 0.599 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.919021e-01 0.717 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.703085e-01 0.769 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.193295e-01 0.659 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.193295e-01 0.659 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.913433e-01 0.536 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.913433e-01 0.536 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.913433e-01 0.536 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.913433e-01 0.536 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.913433e-01 0.536 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 2.913433e-01 0.536 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 2.913433e-01 0.536 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.913433e-01 0.536 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.154657e-01 0.381 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.154657e-01 0.381 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.154657e-01 0.381 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.154657e-01 0.381 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.154657e-01 0.381 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.914300e-01 0.718 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.914300e-01 0.718 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.474829e-01 0.606 0 0
Regulation of IFNG signaling R-HSA-877312 2.474829e-01 0.606 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.474829e-01 0.606 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.474829e-01 0.606 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.474829e-01 0.606 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.474829e-01 0.606 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.474829e-01 0.606 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.474829e-01 0.606 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.133177e-01 0.671 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.305479e-01 0.481 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.305479e-01 0.481 0 0
MET receptor recycling R-HSA-8875656 3.305479e-01 0.481 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.305479e-01 0.481 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.305479e-01 0.481 0 0
FGFR2 alternative splicing R-HSA-6803529 1.856670e-01 0.731 0 0
HIV elongation arrest and recovery R-HSA-167287 1.627190e-01 0.789 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.627190e-01 0.789 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.761414e-01 0.559 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.358523e-01 0.627 0 0
GAB1 signalosome R-HSA-180292 2.358523e-01 0.627 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.589155e-01 0.587 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.589155e-01 0.587 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.050997e-01 0.516 0 0
ARMS-mediated activation R-HSA-170984 3.691196e-01 0.433 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.691196e-01 0.433 0 0
WNT mediated activation of DVL R-HSA-201688 3.691196e-01 0.433 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.691196e-01 0.433 0 0
ALK mutants bind TKIs R-HSA-9700645 3.691196e-01 0.433 0 0
HCN channels R-HSA-1296061 4.749952e-01 0.323 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.749952e-01 0.323 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.749952e-01 0.323 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.749952e-01 0.323 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.749952e-01 0.323 0 0
EGFR downregulation R-HSA-182971 2.104398e-01 0.677 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.823916e-01 0.549 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.823916e-01 0.549 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.823916e-01 0.549 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.823916e-01 0.549 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.823916e-01 0.549 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.341701e-01 0.476 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.341701e-01 0.476 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.341701e-01 0.476 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.341701e-01 0.476 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.446543e-01 0.611 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.067810e-01 0.391 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.826571e-01 0.549 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.826571e-01 0.549 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.012737e-01 0.696 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.012737e-01 0.696 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.631825e-01 0.440 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 3.631825e-01 0.440 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.631825e-01 0.440 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.444339e-01 0.612 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.681042e-01 0.774 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.284475e-01 0.641 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.301395e-01 0.481 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.140284e-01 0.670 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.031969e-01 0.518 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.031969e-01 0.518 0 0
Dual Incision in GG-NER R-HSA-5696400 2.803349e-01 0.552 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.270920e-01 0.644 0 0
Centrosome maturation R-HSA-380287 1.880072e-01 0.726 0 0
Signaling by Erythropoietin R-HSA-9006335 3.239510e-01 0.490 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.919846e-01 0.407 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.919846e-01 0.407 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.433176e-01 0.353 0 0
Signaling by APC mutants R-HSA-4839744 4.433176e-01 0.353 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.433176e-01 0.353 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.433176e-01 0.353 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.433176e-01 0.353 0 0
Degradation of CDH1 R-HSA-9766229 2.725039e-01 0.565 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.782617e-01 0.422 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.272703e-01 0.643 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.272703e-01 0.643 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.820069e-01 0.550 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.204418e-01 0.376 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.204418e-01 0.376 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.658309e-01 0.437 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.488275e-01 0.604 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.107440e-01 0.508 0 0
Meiotic synapsis R-HSA-1221632 3.343903e-01 0.476 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.733357e-01 0.428 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.612422e-01 0.442 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.612422e-01 0.442 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.260214e-01 0.371 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.260214e-01 0.371 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.957554e-01 0.403 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.286375e-01 0.368 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.758673e-01 0.323 0 0
Regulation of signaling by CBL R-HSA-912631 4.758673e-01 0.323 0 0
Signaling by NOTCH2 R-HSA-1980145 4.493407e-01 0.347 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.727906e-01 0.325 0 0
Cristae formation R-HSA-8949613 4.727906e-01 0.325 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.698427e-01 0.328 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.298578e-01 0.367 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.644971e-01 0.333 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.770850e-01 0.752 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.298382e-01 0.367 0 0
HIV Transcription Elongation R-HSA-167169 2.444339e-01 0.612 0 0
Nucleotide Excision Repair R-HSA-5696398 3.787953e-01 0.422 0 0
MET promotes cell motility R-HSA-8875878 3.544966e-01 0.450 0 0
Prolonged ERK activation events R-HSA-169893 1.703085e-01 0.769 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.143632e-01 0.669 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.495646e-01 0.347 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.474829e-01 0.606 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.444339e-01 0.612 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.919846e-01 0.407 0 0
Aggrephagy R-HSA-9646399 3.922012e-01 0.406 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.133177e-01 0.671 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.006245e-01 0.698 0 0
Degradation of DVL R-HSA-4641258 3.357294e-01 0.474 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.890924e-01 0.539 0 0
Interleukin-9 signaling R-HSA-8985947 3.305479e-01 0.481 0 0
Frs2-mediated activation R-HSA-170968 2.761414e-01 0.559 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.006245e-01 0.698 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.623363e-01 0.581 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.358523e-01 0.627 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.446543e-01 0.611 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.325573e-01 0.364 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.150749e-01 0.667 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.597686e-01 0.337 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.810212e-01 0.419 0 0
Regulation of CDH11 function R-HSA-9762292 1.654358e-01 0.781 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.691196e-01 0.433 0 0
Interleukin-21 signaling R-HSA-9020958 3.691196e-01 0.433 0 0
PI3K/AKT activation R-HSA-198203 4.067810e-01 0.391 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.287446e-01 0.641 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.681042e-01 0.774 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.542023e-01 0.451 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.433176e-01 0.353 0 0
Regulation of Apoptosis R-HSA-169911 4.698427e-01 0.328 0 0
Homology Directed Repair R-HSA-5693538 4.479691e-01 0.349 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.907645e-01 0.408 0 0
Adipogenesis R-HSA-9843745 4.124763e-01 0.385 0 0
Myogenesis R-HSA-525793 4.495646e-01 0.347 0 0
Mitophagy R-HSA-5205647 4.493407e-01 0.347 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.050997e-01 0.516 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.301395e-01 0.481 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.542023e-01 0.451 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.260214e-01 0.371 0 0
EPH-Ephrin signaling R-HSA-2682334 2.136739e-01 0.670 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.914300e-01 0.718 0 0
Unwinding of DNA R-HSA-176974 3.691196e-01 0.433 0 0
Regulation of gap junction activity R-HSA-191650 4.749952e-01 0.323 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.839747e-01 0.735 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.170810e-01 0.499 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.253507e-01 0.488 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.922012e-01 0.406 0 0
Interleukin-2 signaling R-HSA-9020558 1.919021e-01 0.717 0 0
Oncogene Induced Senescence R-HSA-2559585 2.985997e-01 0.525 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.583806e-01 0.588 1 1
Glycogen synthesis R-HSA-3322077 2.823916e-01 0.549 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.761201e-01 0.322 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.761201e-01 0.322 0 0
Signal attenuation R-HSA-74749 1.654358e-01 0.781 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.493407e-01 0.347 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.727906e-01 0.325 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.896775e-01 0.538 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.644620e-01 0.578 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.239510e-01 0.490 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.448509e-01 0.462 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.698427e-01 0.328 0 0
Signalling to ERKs R-HSA-187687 2.985997e-01 0.525 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.617321e-01 0.791 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.378512e-01 0.624 0 0
Insulin receptor signalling cascade R-HSA-74751 3.698402e-01 0.432 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.125311e-01 0.673 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.940057e-01 0.712 0 0
Calcineurin activates NFAT R-HSA-2025928 3.691196e-01 0.433 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.061687e-01 0.514 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.919846e-01 0.407 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.932956e-01 0.533 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.448509e-01 0.462 0 0
IRS-mediated signalling R-HSA-112399 2.679236e-01 0.572 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.868280e-01 0.412 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.485283e-01 0.348 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.698427e-01 0.328 0 0
Synthesis of DNA R-HSA-69239 4.023835e-01 0.395 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.597686e-01 0.337 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.174705e-01 0.498 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.782617e-01 0.422 0 0
IGF1R signaling cascade R-HSA-2428924 3.698402e-01 0.432 0 0
Signaling by WNT R-HSA-195721 3.972565e-01 0.401 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.914300e-01 0.718 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.031920e-01 0.518 0 0
UCH proteinases R-HSA-5689603 4.151263e-01 0.382 0 0
Signaling by FGFR2 R-HSA-5654738 2.421079e-01 0.616 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.322483e-01 0.479 0 0
Signaling by FGFR4 R-HSA-5654743 3.100568e-01 0.509 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.154657e-01 0.381 0 0
FasL/ CD95L signaling R-HSA-75157 4.154657e-01 0.381 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.341701e-01 0.476 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.624017e-01 0.581 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.542023e-01 0.451 0 0
Rab regulation of trafficking R-HSA-9007101 1.766436e-01 0.753 0 0
Nuclear RNA decay R-HSA-9930044 4.077824e-01 0.390 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.039766e-01 0.690 0 0
Generation of second messenger molecules R-HSA-202433 3.922012e-01 0.406 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.544966e-01 0.450 0 0
Signaling by FGFR3 R-HSA-5654741 3.440669e-01 0.463 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.848152e-01 0.415 0 0
Rap1 signalling R-HSA-392517 2.589155e-01 0.587 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.446543e-01 0.611 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.446543e-01 0.611 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.922012e-01 0.406 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.922012e-01 0.406 0 0
The NLRP3 inflammasome R-HSA-844456 2.589155e-01 0.587 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.803349e-01 0.552 0 0
ESR-mediated signaling R-HSA-8939211 3.473850e-01 0.459 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.784834e-01 0.422 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.481550e-01 0.458 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.341701e-01 0.476 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.542023e-01 0.451 0 0
Signaling by NOTCH R-HSA-157118 4.436402e-01 0.353 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.260214e-01 0.371 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.780837e-01 0.749 0 0
Adaptive Immune System R-HSA-1280218 4.205322e-01 0.376 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.617321e-01 0.791 0 0
Glycogen metabolism R-HSA-8982491 3.922012e-01 0.406 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.597119e-01 0.797 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.932617e-01 0.714 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.754061e-01 0.560 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.491907e-01 0.457 0 0
Signalling to ERK5 R-HSA-198765 3.491907e-01 0.457 0 0
C6 deamination of adenosine R-HSA-75102 3.491907e-01 0.457 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.654358e-01 0.781 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.154657e-01 0.381 0 0
MET interacts with TNS proteins R-HSA-8875513 4.154657e-01 0.381 0 0
Signaling by LTK R-HSA-9842663 2.474829e-01 0.606 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.305479e-01 0.481 0 0
mTORC1-mediated signalling R-HSA-166208 1.856670e-01 0.731 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.761414e-01 0.559 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.230319e-01 0.652 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.446543e-01 0.611 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.067810e-01 0.391 1 1
Deadenylation-dependent mRNA decay R-HSA-429914 1.892929e-01 0.723 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.803349e-01 0.552 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.239510e-01 0.490 0 0
Disorders of Developmental Biology R-HSA-9675151 3.919846e-01 0.407 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.433176e-01 0.353 0 0
Orc1 removal from chromatin R-HSA-68949 3.186689e-01 0.497 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.544966e-01 0.450 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.484365e-01 0.348 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.758673e-01 0.323 0 0
PI3K Cascade R-HSA-109704 4.302587e-01 0.366 0 0
Integration of energy metabolism R-HSA-163685 3.808014e-01 0.419 1 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.446543e-01 0.611 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 3.089812e-01 0.510 0 0
Signaling by FGFR in disease R-HSA-1226099 2.707372e-01 0.567 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.604468e-01 0.584 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.357294e-01 0.474 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.919846e-01 0.407 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.653277e-01 0.576 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.616096e-01 0.792 0 0
rRNA processing R-HSA-72312 3.094364e-01 0.509 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.077824e-01 0.390 0 0
Developmental Biology R-HSA-1266738 3.220223e-01 0.492 0 0
Integration of provirus R-HSA-162592 2.193295e-01 0.659 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.341701e-01 0.476 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.341701e-01 0.476 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.698427e-01 0.328 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.664559e-01 0.574 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.485283e-01 0.348 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.782617e-01 0.422 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.127143e-01 0.505 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.227673e-01 0.652 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.620663e-01 0.335 0 0
HDMs demethylate histones R-HSA-3214842 2.425024e-01 0.615 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.273389e-01 0.643 0 0
Signaling by NOTCH3 R-HSA-9012852 2.404436e-01 0.619 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.125311e-01 0.673 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.913433e-01 0.536 0 0
Carnitine shuttle R-HSA-200425 3.782617e-01 0.422 1 1
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.727906e-01 0.325 0 0
Signaling by TGFB family members R-HSA-9006936 3.621249e-01 0.441 0 0
Regulated Necrosis R-HSA-5218859 4.298578e-01 0.367 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.957746e-01 0.708 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.542023e-01 0.451 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.067810e-01 0.391 0 0
MHC class II antigen presentation R-HSA-2132295 4.020910e-01 0.396 0 0
Netrin-1 signaling R-HSA-373752 3.269929e-01 0.485 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.620663e-01 0.335 0 0
G2/M Checkpoints R-HSA-69481 4.572782e-01 0.340 0 0
ABC-family proteins mediated transport R-HSA-382556 4.146491e-01 0.382 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.940057e-01 0.712 0 0
Interleukin-20 family signaling R-HSA-8854691 3.782617e-01 0.422 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.342795e-01 0.630 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.055020e-01 0.687 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.871317e-01 0.542 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.871317e-01 0.542 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.871317e-01 0.542 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.125311e-01 0.673 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.691196e-01 0.433 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.691196e-01 0.433 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.749952e-01 0.323 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.067810e-01 0.391 0 0
Signaling by ALK R-HSA-201556 2.287446e-01 0.641 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.826571e-01 0.549 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.631825e-01 0.440 0 0
snRNP Assembly R-HSA-191859 1.892929e-01 0.723 0 0
Metabolism of non-coding RNA R-HSA-194441 1.892929e-01 0.723 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.239510e-01 0.490 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.919846e-01 0.407 0 0
Synthesis of PI R-HSA-1483226 4.433176e-01 0.353 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.433176e-01 0.353 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.236555e-01 0.490 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.727906e-01 0.325 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.542023e-01 0.451 0 0
Downstream signal transduction R-HSA-186763 2.104398e-01 0.677 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.681756e-01 0.572 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.585711e-01 0.445 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.067810e-01 0.391 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.922012e-01 0.406 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.682509e-01 0.434 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.284475e-01 0.641 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.022923e-01 0.395 0 0
Neurofascin interactions R-HSA-447043 2.518578e-01 0.599 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.302587e-01 0.366 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.957554e-01 0.403 0 0
Mitochondrial biogenesis R-HSA-1592230 3.367677e-01 0.473 1 0
Potential therapeutics for SARS R-HSA-9679191 3.520404e-01 0.453 0 0
Glucose metabolism R-HSA-70326 3.367677e-01 0.473 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.714025e-01 0.430 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.287446e-01 0.641 0 0
Signaling by ERBB4 R-HSA-1236394 3.867789e-01 0.413 0 0
Inositol phosphate metabolism R-HSA-1483249 4.615706e-01 0.336 0 0
Interleukin-6 family signaling R-HSA-6783589 4.022287e-01 0.396 0 0
DNA Damage Bypass R-HSA-73893 4.130247e-01 0.384 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.301395e-01 0.481 0 0
Co-stimulation by CD28 R-HSA-389356 3.957554e-01 0.403 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.754061e-01 0.560 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.040628e-01 0.690 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.691196e-01 0.433 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.749952e-01 0.323 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.067810e-01 0.391 0 0
Metal ion SLC transporters R-HSA-425410 2.575458e-01 0.589 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.413651e-01 0.355 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.826571e-01 0.549 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.844972e-01 0.734 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.826571e-01 0.549 0 0
Zinc transporters R-HSA-435354 3.050997e-01 0.516 0 0
Regulation of beta-cell development R-HSA-186712 1.892929e-01 0.723 0 0
Signaling by KIT in disease R-HSA-9669938 3.542023e-01 0.451 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.474829e-01 0.606 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.597686e-01 0.337 0 0
Tie2 Signaling R-HSA-210993 4.484365e-01 0.348 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.125311e-01 0.673 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.913433e-01 0.536 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.761414e-01 0.559 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.691196e-01 0.433 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.341701e-01 0.476 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.631121e-01 0.788 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.204418e-01 0.376 0 0
Selenoamino acid metabolism R-HSA-2408522 2.439683e-01 0.613 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.803349e-01 0.552 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.270920e-01 0.644 0 0
Nephrin family interactions R-HSA-373753 2.823916e-01 0.549 0 0
Signaling by NOTCH4 R-HSA-9013694 1.779215e-01 0.750 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.911496e-01 0.536 0 0
Growth hormone receptor signaling R-HSA-982772 3.782617e-01 0.422 0 0
PKR-mediated signaling R-HSA-9833482 4.716529e-01 0.326 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.758673e-01 0.323 0 0
Interleukin-37 signaling R-HSA-9008059 1.940057e-01 0.712 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.766052e-01 0.322 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.778670e-01 0.321 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.778670e-01 0.321 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.785681e-01 0.320 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.785681e-01 0.320 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.785681e-01 0.320 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.785681e-01 0.320 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.785681e-01 0.320 0 0
Signaling by AXIN mutants R-HSA-4839735 4.785681e-01 0.320 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.785681e-01 0.320 0 0
Sodium/Calcium exchangers R-HSA-425561 4.785681e-01 0.320 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.790631e-01 0.320 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.805436e-01 0.318 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.814435e-01 0.317 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.814435e-01 0.317 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.814435e-01 0.317 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.814435e-01 0.317 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.851120e-01 0.314 0 0
G1 Phase R-HSA-69236 4.854640e-01 0.314 0 0
Cyclin D associated events in G1 R-HSA-69231 4.854640e-01 0.314 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.856486e-01 0.314 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.876879e-01 0.312 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.897293e-01 0.310 1 0
Deubiquitination R-HSA-5688426 4.900379e-01 0.310 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.900983e-01 0.310 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.900983e-01 0.310 0 0
RUNX2 regulates bone development R-HSA-8941326 4.900983e-01 0.310 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.935522e-01 0.307 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.956385e-01 0.305 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.956385e-01 0.305 1 1
FRS-mediated FGFR2 signaling R-HSA-5654700 4.956385e-01 0.305 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.956385e-01 0.305 0 0
Inflammasomes R-HSA-622312 4.956385e-01 0.305 0 0
Reproduction R-HSA-1474165 5.011467e-01 0.300 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.026482e-01 0.299 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.026482e-01 0.299 0 0
Negative regulation of MET activity R-HSA-6807004 5.026482e-01 0.299 0 0
Signal transduction by L1 R-HSA-445144 5.026482e-01 0.299 0 0
Formation of definitive endoderm R-HSA-9823730 5.026482e-01 0.299 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.036416e-01 0.298 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.036416e-01 0.298 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.036416e-01 0.298 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.036416e-01 0.298 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.036416e-01 0.298 0 0
Signaling by FGFR R-HSA-190236 5.043851e-01 0.297 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.049541e-01 0.297 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.084583e-01 0.294 1 1
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.100661e-01 0.292 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.124156e-01 0.290 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.124156e-01 0.290 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.124156e-01 0.290 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.124156e-01 0.290 0 0
Interleukin-15 signaling R-HSA-8983432 5.124156e-01 0.290 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.124156e-01 0.290 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.124156e-01 0.290 0 0
Repression of WNT target genes R-HSA-4641265 5.124156e-01 0.290 0 0
MET activates RAS signaling R-HSA-8851805 5.124156e-01 0.290 0 0
Disorders of Nervous System Development R-HSA-9697154 5.124156e-01 0.290 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.124156e-01 0.290 0 0
Pervasive developmental disorders R-HSA-9005895 5.124156e-01 0.290 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.124156e-01 0.290 0 0
OAS antiviral response R-HSA-8983711 5.124156e-01 0.290 0 0
Leading Strand Synthesis R-HSA-69109 5.124156e-01 0.290 0 0
Polymerase switching R-HSA-69091 5.124156e-01 0.290 0 0
Gene Silencing by RNA R-HSA-211000 5.125244e-01 0.290 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.148567e-01 0.288 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.151717e-01 0.288 0 0
mRNA Capping R-HSA-72086 5.180541e-01 0.286 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.180541e-01 0.286 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.180541e-01 0.286 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.180541e-01 0.286 0 0
Glucagon-type ligand receptors R-HSA-420092 5.180541e-01 0.286 0 0
DARPP-32 events R-HSA-180024 5.180541e-01 0.286 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.215844e-01 0.283 0 0
Signaling by TGFBR3 R-HSA-9839373 5.215844e-01 0.283 0 0
Diseases of DNA repair R-HSA-9675135 5.215844e-01 0.283 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.228109e-01 0.282 0 0
Cellular response to hypoxia R-HSA-1234174 5.244925e-01 0.280 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.284653e-01 0.277 0 0
PTK6 Down-Regulation R-HSA-8849472 5.284653e-01 0.277 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.284653e-01 0.277 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.284653e-01 0.277 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.284653e-01 0.277 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.284653e-01 0.277 0 0
Inositol transporters R-HSA-429593 5.284653e-01 0.277 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.284653e-01 0.277 0 0
Co-inhibition by BTLA R-HSA-9927353 5.284653e-01 0.277 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.284653e-01 0.277 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.284653e-01 0.277 0 0
Basigin interactions R-HSA-210991 5.287072e-01 0.277 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.287072e-01 0.277 0 0
G-protein activation R-HSA-202040 5.287072e-01 0.277 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.287072e-01 0.277 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.287072e-01 0.277 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.287072e-01 0.277 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.292594e-01 0.276 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.312749e-01 0.275 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.312749e-01 0.275 0 0
Signaling by FGFR1 R-HSA-5654736 5.312749e-01 0.275 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.329867e-01 0.273 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.329867e-01 0.273 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.364192e-01 0.270 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.392643e-01 0.268 0 0
Activation of the pre-replicative complex R-HSA-68962 5.399902e-01 0.268 0 0
DAP12 signaling R-HSA-2424491 5.399902e-01 0.268 0 0
Activation of BH3-only proteins R-HSA-114452 5.399902e-01 0.268 0 0
Meiosis R-HSA-1500620 5.406164e-01 0.267 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.447802e-01 0.264 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.447802e-01 0.264 0 0
Formation of axial mesoderm R-HSA-9796292 5.447802e-01 0.264 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.447802e-01 0.264 0 0
TCR signaling R-HSA-202403 5.482254e-01 0.261 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.489914e-01 0.260 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.489914e-01 0.260 0 0
Stabilization of p53 R-HSA-69541 5.489914e-01 0.260 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.489914e-01 0.260 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.539725e-01 0.257 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.539858e-01 0.257 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.539858e-01 0.257 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.539858e-01 0.257 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.539858e-01 0.257 0 0
Gene expression (Transcription) R-HSA-74160 5.594315e-01 0.252 1 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.614058e-01 0.251 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.614058e-01 0.251 0 0
Dual incision in TC-NER R-HSA-6782135 5.634256e-01 0.249 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.654998e-01 0.248 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.654998e-01 0.248 0 0
Interleukin-2 family signaling R-HSA-451927 5.678850e-01 0.246 0 0
Gap junction trafficking and regulation R-HSA-157858 5.737356e-01 0.241 0 0
PCP/CE pathway R-HSA-4086400 5.751684e-01 0.240 0 0
Removal of the Flap Intermediate R-HSA-69166 5.756129e-01 0.240 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.756129e-01 0.240 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.756129e-01 0.240 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.756129e-01 0.240 0 0
Physiological factors R-HSA-5578768 5.756129e-01 0.240 0 0
Prolactin receptor signaling R-HSA-1170546 5.756129e-01 0.240 0 0
Plus-strand DNA synthesis R-HSA-164525 5.764924e-01 0.239 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.764924e-01 0.239 0 0
PDE3B signalling R-HSA-165160 5.764924e-01 0.239 0 0
PKB-mediated events R-HSA-109703 5.764924e-01 0.239 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.764924e-01 0.239 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.764924e-01 0.239 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.764924e-01 0.239 0 0
Phosphorylation of Emi1 R-HSA-176417 5.764924e-01 0.239 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.764924e-01 0.239 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 5.764924e-01 0.239 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.764924e-01 0.239 0 0
TRAIL signaling R-HSA-75158 5.764924e-01 0.239 0 0
NGF-independant TRKA activation R-HSA-187024 5.764924e-01 0.239 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.764924e-01 0.239 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.764924e-01 0.239 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.764924e-01 0.239 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.764924e-01 0.239 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.764924e-01 0.239 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.764924e-01 0.239 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.764924e-01 0.239 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.784372e-01 0.238 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.784372e-01 0.238 0 0
Pyruvate metabolism R-HSA-70268 5.803937e-01 0.236 0 0
DNA strand elongation R-HSA-69190 5.822660e-01 0.235 0 0
Ub-specific processing proteases R-HSA-5689880 5.842410e-01 0.233 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.863627e-01 0.232 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.863627e-01 0.232 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.975582e-01 0.224 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.984964e-01 0.223 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.984964e-01 0.223 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.020260e-01 0.220 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.020260e-01 0.220 0 0
Syndecan interactions R-HSA-3000170 6.020260e-01 0.220 0 0
G-protein beta:gamma signalling R-HSA-397795 6.025419e-01 0.220 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.025419e-01 0.220 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.025419e-01 0.220 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.025419e-01 0.220 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.044015e-01 0.219 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.048901e-01 0.218 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.048901e-01 0.218 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.048901e-01 0.218 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.048901e-01 0.218 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.048901e-01 0.218 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.048901e-01 0.218 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.048901e-01 0.218 0 0
Biotin transport and metabolism R-HSA-196780 6.048901e-01 0.218 0 0
Other semaphorin interactions R-HSA-416700 6.048901e-01 0.218 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.048901e-01 0.218 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.068797e-01 0.217 0 0
SARS-CoV Infections R-HSA-9679506 6.123462e-01 0.213 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.125862e-01 0.213 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.125862e-01 0.213 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.196304e-01 0.208 0 0
Signaling by LTK in cancer R-HSA-9842640 6.196304e-01 0.208 0 0
Chylomicron clearance R-HSA-8964026 6.196304e-01 0.208 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.196304e-01 0.208 0 0
Uncoating of the HIV Virion R-HSA-162585 6.196304e-01 0.208 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.196304e-01 0.208 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.196304e-01 0.208 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.196304e-01 0.208 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.196304e-01 0.208 0 0
HDL clearance R-HSA-8964011 6.196304e-01 0.208 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.222097e-01 0.206 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.222097e-01 0.206 0 0
Heme degradation R-HSA-189483 6.222097e-01 0.206 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.222097e-01 0.206 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.229093e-01 0.206 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.244782e-01 0.204 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.247126e-01 0.204 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.247262e-01 0.204 0 0
Complex III assembly R-HSA-9865881 6.247262e-01 0.204 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.309088e-01 0.200 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.309088e-01 0.200 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.326086e-01 0.199 0 0
Phosphorylation of the APC/C R-HSA-176412 6.326086e-01 0.199 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.326086e-01 0.199 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.326086e-01 0.199 0 0
Killing mechanisms R-HSA-9664420 6.326086e-01 0.199 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.326086e-01 0.199 0 0
Atorvastatin ADME R-HSA-9754706 6.326086e-01 0.199 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.326086e-01 0.199 0 0
Differentiation of T cells R-HSA-9945266 6.326086e-01 0.199 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.390873e-01 0.194 0 0
Defective pyroptosis R-HSA-9710421 6.390873e-01 0.194 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.390873e-01 0.194 0 0
Ca2+ pathway R-HSA-4086398 6.399885e-01 0.194 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.412510e-01 0.193 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.412510e-01 0.193 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.412510e-01 0.193 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.412510e-01 0.193 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.412510e-01 0.193 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.465212e-01 0.189 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.465212e-01 0.189 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.465212e-01 0.189 0 0
Long-term potentiation R-HSA-9620244 6.465212e-01 0.189 0 0
Interleukin-7 signaling R-HSA-1266695 6.465212e-01 0.189 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.465212e-01 0.189 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.465212e-01 0.189 0 0
Cilium Assembly R-HSA-5617833 6.492136e-01 0.188 0 0
Ion transport by P-type ATPases R-HSA-936837 6.531506e-01 0.185 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.539161e-01 0.184 0 0
Gap junction trafficking R-HSA-190828 6.557045e-01 0.183 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.583767e-01 0.182 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.583767e-01 0.182 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.583767e-01 0.182 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.583767e-01 0.182 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.583767e-01 0.182 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.583767e-01 0.182 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.583767e-01 0.182 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.583767e-01 0.182 0 0
VLDL clearance R-HSA-8964046 6.583767e-01 0.182 0 0
Activation of TRKA receptors R-HSA-187015 6.583767e-01 0.182 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.583767e-01 0.182 0 0
Netrin mediated repulsion signals R-HSA-418886 6.583767e-01 0.182 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.583767e-01 0.182 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.583767e-01 0.182 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.583767e-01 0.182 0 0
CHL1 interactions R-HSA-447041 6.583767e-01 0.182 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.583767e-01 0.182 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.583767e-01 0.182 0 0
Maturation of replicase proteins R-HSA-9694301 6.583767e-01 0.182 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.587823e-01 0.181 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.587823e-01 0.181 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.587823e-01 0.181 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.596518e-01 0.181 0 0
PERK regulates gene expression R-HSA-381042 6.596518e-01 0.181 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.674018e-01 0.176 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.674018e-01 0.176 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.674018e-01 0.176 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.674018e-01 0.176 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.674018e-01 0.176 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.674018e-01 0.176 0 0
Somitogenesis R-HSA-9824272 6.718228e-01 0.173 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.718228e-01 0.173 0 0
Neddylation R-HSA-8951664 6.719770e-01 0.173 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.774026e-01 0.169 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.782204e-01 0.169 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.782204e-01 0.169 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.784683e-01 0.168 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.789615e-01 0.168 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.831082e-01 0.166 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.834382e-01 0.165 0 0
Glycogen storage diseases R-HSA-3229121 6.834382e-01 0.165 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.834382e-01 0.165 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.834382e-01 0.165 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.834382e-01 0.165 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.873661e-01 0.163 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.874346e-01 0.163 0 0
Opioid Signalling R-HSA-111885 6.889676e-01 0.162 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.931781e-01 0.159 0 0
Minus-strand DNA synthesis R-HSA-164516 6.931781e-01 0.159 0 0
Regulation by c-FLIP R-HSA-3371378 6.931781e-01 0.159 0 0
Dimerization of procaspase-8 R-HSA-69416 6.931781e-01 0.159 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.931781e-01 0.159 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.931781e-01 0.159 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.931781e-01 0.159 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.931781e-01 0.159 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.931781e-01 0.159 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.931781e-01 0.159 0 0
Activation of RAS in B cells R-HSA-1169092 6.931781e-01 0.159 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.931781e-01 0.159 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.931781e-01 0.159 0 0
Alpha-defensins R-HSA-1462054 6.931781e-01 0.159 0 0
Degradation of AXIN R-HSA-4641257 6.944978e-01 0.158 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.014635e-01 0.154 0 0
Viral Infection Pathways R-HSA-9824446 7.016048e-01 0.154 0 0
RNA Polymerase I Transcription R-HSA-73864 7.034434e-01 0.153 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.063992e-01 0.151 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.064178e-01 0.151 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.064178e-01 0.151 0 0
Pyroptosis R-HSA-5620971 7.064178e-01 0.151 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.066138e-01 0.151 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.066138e-01 0.151 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.066138e-01 0.151 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.066138e-01 0.151 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.066138e-01 0.151 0 0
Platelet sensitization by LDL R-HSA-432142 7.066138e-01 0.151 0 0
Nephron development R-HSA-9831926 7.066138e-01 0.151 0 0
Mismatch Repair R-HSA-5358508 7.066138e-01 0.151 0 0
Parasite infection R-HSA-9664407 7.087614e-01 0.149 0 0
Leishmania phagocytosis R-HSA-9664417 7.087614e-01 0.149 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.087614e-01 0.149 0 0
Extension of Telomeres R-HSA-180786 7.239164e-01 0.140 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.244361e-01 0.140 0 0
CASP8 activity is inhibited R-HSA-5218900 7.244361e-01 0.140 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.244361e-01 0.140 1 1
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.244361e-01 0.140 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.244361e-01 0.140 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.244361e-01 0.140 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.244361e-01 0.140 0 0
mRNA Editing R-HSA-75072 7.244361e-01 0.140 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.244361e-01 0.140 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.244361e-01 0.140 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.244361e-01 0.140 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.244361e-01 0.140 0 0
Interleukin-1 processing R-HSA-448706 7.244361e-01 0.140 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.244361e-01 0.140 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.244361e-01 0.140 0 0
DNA methylation R-HSA-5334118 7.245663e-01 0.140 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.245663e-01 0.140 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 7.245663e-01 0.140 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.266830e-01 0.139 0 0
Pentose phosphate pathway R-HSA-71336 7.267169e-01 0.139 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.267169e-01 0.139 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.283549e-01 0.138 0 0
Pyrimidine biosynthesis R-HSA-500753 7.283549e-01 0.138 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.283549e-01 0.138 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.308875e-01 0.136 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.339057e-01 0.134 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.378304e-01 0.132 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.418461e-01 0.130 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.418461e-01 0.130 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.418461e-01 0.130 0 0
DNA Replication R-HSA-69306 7.421359e-01 0.130 0 0
Hedgehog 'on' state R-HSA-5632684 7.425882e-01 0.129 0 0
DNA Repair R-HSA-73894 7.479145e-01 0.126 0 0
RNA Polymerase II Transcription R-HSA-73857 7.479718e-01 0.126 1 0
Co-inhibition by CTLA4 R-HSA-389513 7.487132e-01 0.126 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.487132e-01 0.126 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.487132e-01 0.126 0 0
Pregnenolone biosynthesis R-HSA-196108 7.487132e-01 0.126 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.487132e-01 0.126 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.487132e-01 0.126 0 0
Signaling by NODAL R-HSA-1181150 7.487132e-01 0.126 0 0
Protein hydroxylation R-HSA-9629569 7.487132e-01 0.126 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.487132e-01 0.126 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.488874e-01 0.126 1 0
Neutrophil degranulation R-HSA-6798695 7.491003e-01 0.125 0 0
Binding and entry of HIV virion R-HSA-173107 7.525114e-01 0.123 0 0
2-LTR circle formation R-HSA-164843 7.525114e-01 0.123 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.525114e-01 0.123 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.525114e-01 0.123 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.525114e-01 0.123 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.525114e-01 0.123 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.525114e-01 0.123 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.525114e-01 0.123 0 0
Interleukin-27 signaling R-HSA-9020956 7.525114e-01 0.123 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.525114e-01 0.123 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.525114e-01 0.123 0 0
Serotonin receptors R-HSA-390666 7.525114e-01 0.123 0 0
Josephin domain DUBs R-HSA-5689877 7.525114e-01 0.123 0 0
Platelet degranulation R-HSA-114608 7.534580e-01 0.123 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.563299e-01 0.121 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.563299e-01 0.121 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.563299e-01 0.121 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.577866e-01 0.120 0 0
Cargo concentration in the ER R-HSA-5694530 7.582118e-01 0.120 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.607525e-01 0.119 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.609040e-01 0.119 0 0
Signaling by PDGF R-HSA-186797 7.609040e-01 0.119 0 0
Protein folding R-HSA-391251 7.645570e-01 0.117 0 0
Signaling by Insulin receptor R-HSA-74752 7.645570e-01 0.117 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.677446e-01 0.115 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.677446e-01 0.115 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.677446e-01 0.115 0 0
Lagging Strand Synthesis R-HSA-69186 7.677446e-01 0.115 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.677446e-01 0.115 0 0
Signalling to RAS R-HSA-167044 7.677446e-01 0.115 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.677446e-01 0.115 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.701773e-01 0.113 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.701773e-01 0.113 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.701773e-01 0.113 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.701773e-01 0.113 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.701773e-01 0.113 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.703227e-01 0.113 0 0
Signaling by WNT in cancer R-HSA-4791275 7.737469e-01 0.111 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.755165e-01 0.110 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.777277e-01 0.109 0 0
LGI-ADAM interactions R-HSA-5682910 7.777277e-01 0.109 0 0
vRNP Assembly R-HSA-192905 7.777277e-01 0.109 0 0
vRNA Synthesis R-HSA-192814 7.777277e-01 0.109 0 0
Bicarbonate transporters R-HSA-425381 7.777277e-01 0.109 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 7.777277e-01 0.109 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.777277e-01 0.109 0 0
Chylomicron assembly R-HSA-8963888 7.777277e-01 0.109 0 0
PECAM1 interactions R-HSA-210990 7.777277e-01 0.109 0 0
Transport of RCbl within the body R-HSA-9758890 7.777277e-01 0.109 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.777277e-01 0.109 0 0
Chromosome Maintenance R-HSA-73886 7.806105e-01 0.108 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.833432e-01 0.106 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.855082e-01 0.105 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.855082e-01 0.105 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.855082e-01 0.105 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.855082e-01 0.105 0 0
Cardiogenesis R-HSA-9733709 7.884537e-01 0.103 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.003761e-01 0.097 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.003761e-01 0.097 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.003761e-01 0.097 0 0
NF-kB is activated and signals survival R-HSA-209560 8.003761e-01 0.097 0 0
ERKs are inactivated R-HSA-202670 8.003761e-01 0.097 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.003761e-01 0.097 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.003761e-01 0.097 0 0
LDL clearance R-HSA-8964038 8.020646e-01 0.096 0 0
Toll-like Receptor Cascades R-HSA-168898 8.022685e-01 0.096 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.023575e-01 0.096 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.023575e-01 0.096 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.079964e-01 0.093 0 0
Proteasome assembly R-HSA-9907900 8.080194e-01 0.093 0 0
DAP12 interactions R-HSA-2172127 8.080194e-01 0.093 0 0
RMTs methylate histone arginines R-HSA-3214858 8.080194e-01 0.093 0 0
Amine ligand-binding receptors R-HSA-375280 8.080194e-01 0.093 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.094385e-01 0.092 0 0
DNA Double Strand Break Response R-HSA-5693606 8.141967e-01 0.089 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.144328e-01 0.089 0 0
ABC transporter disorders R-HSA-5619084 8.144328e-01 0.089 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.154851e-01 0.089 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.154851e-01 0.089 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.154851e-01 0.089 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.155356e-01 0.089 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.155356e-01 0.089 0 0
Interferon Signaling R-HSA-913531 8.159276e-01 0.088 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.174755e-01 0.088 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.174755e-01 0.088 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.174755e-01 0.088 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.174755e-01 0.088 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.174755e-01 0.088 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.174755e-01 0.088 0 0
Telomere Maintenance R-HSA-157579 8.175904e-01 0.087 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.194470e-01 0.086 0 0
Nucleosome assembly R-HSA-774815 8.194470e-01 0.086 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.194470e-01 0.086 0 0
DAG and IP3 signaling R-HSA-1489509 8.194470e-01 0.086 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.207179e-01 0.086 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.207179e-01 0.086 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.207179e-01 0.086 0 0
Interleukin-35 Signalling R-HSA-8984722 8.207179e-01 0.086 0 0
Proline catabolism R-HSA-70688 8.207179e-01 0.086 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.207179e-01 0.086 0 0
Synthesis of GDP-mannose R-HSA-446205 8.207179e-01 0.086 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.207179e-01 0.086 0 0
Sensory processing of sound R-HSA-9659379 8.232972e-01 0.084 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.296675e-01 0.081 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.303079e-01 0.081 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.303079e-01 0.081 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.318022e-01 0.080 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.318022e-01 0.080 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.318022e-01 0.080 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.318022e-01 0.080 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.318022e-01 0.080 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.318022e-01 0.080 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.318022e-01 0.080 0 0
Neuronal System R-HSA-112316 8.368445e-01 0.077 1 0
Adenylate cyclase activating pathway R-HSA-170660 8.389880e-01 0.076 0 0
Chylomicron remodeling R-HSA-8963901 8.389880e-01 0.076 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.389880e-01 0.076 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.389880e-01 0.076 0 0
Processing of SMDT1 R-HSA-8949664 8.389880e-01 0.076 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.389880e-01 0.076 0 0
Maturation of nucleoprotein R-HSA-9683610 8.389880e-01 0.076 0 0
Triglyceride catabolism R-HSA-163560 8.395253e-01 0.076 0 0
Calmodulin induced events R-HSA-111933 8.395253e-01 0.076 0 0
CaM pathway R-HSA-111997 8.395253e-01 0.076 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.395253e-01 0.076 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.405826e-01 0.075 0 0
HCMV Late Events R-HSA-9610379 8.405826e-01 0.075 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.406193e-01 0.075 0 0
COPII-mediated vesicle transport R-HSA-204005 8.413992e-01 0.075 0 0
Generic Transcription Pathway R-HSA-212436 8.423905e-01 0.074 1 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.445295e-01 0.073 0 0
Triglyceride metabolism R-HSA-8979227 8.445295e-01 0.073 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.445295e-01 0.073 0 0
G protein gated Potassium channels R-HSA-1296059 8.451058e-01 0.073 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.451058e-01 0.073 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.451058e-01 0.073 0 0
Tight junction interactions R-HSA-420029 8.451058e-01 0.073 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.451058e-01 0.073 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.451058e-01 0.073 0 0
Laminin interactions R-HSA-3000157 8.451058e-01 0.073 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.451058e-01 0.073 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.497170e-01 0.071 0 0
Voltage gated Potassium channels R-HSA-1296072 8.504964e-01 0.070 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.504964e-01 0.070 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.533175e-01 0.069 0 0
Metabolism of polyamines R-HSA-351202 8.533175e-01 0.069 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.553972e-01 0.068 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.553972e-01 0.068 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.553972e-01 0.068 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.553972e-01 0.068 0 0
TRP channels R-HSA-3295583 8.574457e-01 0.067 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.574457e-01 0.067 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.574457e-01 0.067 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.574457e-01 0.067 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.608078e-01 0.065 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.608078e-01 0.065 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.612494e-01 0.065 0 0
Cardiac conduction R-HSA-5576891 8.630673e-01 0.064 0 0
Packaging Of Telomere Ends R-HSA-171306 8.688803e-01 0.061 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.688803e-01 0.061 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.688803e-01 0.061 0 0
Signaling by BMP R-HSA-201451 8.688803e-01 0.061 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.688803e-01 0.061 0 0
Triglyceride biosynthesis R-HSA-75109 8.688803e-01 0.061 0 0
Insulin processing R-HSA-264876 8.688803e-01 0.061 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.701349e-01 0.060 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.701349e-01 0.060 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.701349e-01 0.060 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.701349e-01 0.060 0 0
p38MAPK events R-HSA-171007 8.701349e-01 0.060 0 0
Protein lipoylation R-HSA-9857492 8.701349e-01 0.060 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.701349e-01 0.060 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.701349e-01 0.060 0 0
p75NTR signals via NF-kB R-HSA-193639 8.701349e-01 0.060 0 0
DNA Damage Reversal R-HSA-73942 8.701349e-01 0.060 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.704893e-01 0.060 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.711645e-01 0.060 0 0
Interleukin-1 family signaling R-HSA-446652 8.711645e-01 0.060 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.744514e-01 0.058 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.767329e-01 0.057 0 0
Telomere Extension By Telomerase R-HSA-171319 8.794659e-01 0.056 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.794659e-01 0.056 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.795705e-01 0.056 0 0
Diseases of Immune System R-HSA-5260271 8.795705e-01 0.056 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.833714e-01 0.054 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.833714e-01 0.054 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.833714e-01 0.054 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.833714e-01 0.054 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.833714e-01 0.054 0 0
Activation of SMO R-HSA-5635838 8.833714e-01 0.054 0 0
Attachment and Entry R-HSA-9678110 8.833714e-01 0.054 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.841365e-01 0.053 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.841365e-01 0.053 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.841365e-01 0.053 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.844243e-01 0.053 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.845717e-01 0.053 0 0
Potassium Channels R-HSA-1296071 8.864638e-01 0.052 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.880808e-01 0.052 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.880808e-01 0.052 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.919723e-01 0.050 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.952594e-01 0.048 0 0
Phase 2 - plateau phase R-HSA-5576893 8.952594e-01 0.048 0 0
Galactose catabolism R-HSA-70370 8.952594e-01 0.048 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.952594e-01 0.048 0 0
Coenzyme A biosynthesis R-HSA-196783 8.952594e-01 0.048 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.952594e-01 0.048 0 0
Intra-Golgi traffic R-HSA-6811438 8.960489e-01 0.048 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.983046e-01 0.047 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.983046e-01 0.047 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.983046e-01 0.047 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.985088e-01 0.046 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.989165e-01 0.046 0 0
Immune System R-HSA-168256 9.031821e-01 0.044 0 0
Activation of GABAB receptors R-HSA-991365 9.035029e-01 0.044 0 0
GABA B receptor activation R-HSA-977444 9.035029e-01 0.044 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.035029e-01 0.044 0 0
Ca-dependent events R-HSA-111996 9.035029e-01 0.044 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.035029e-01 0.044 0 0
Depyrimidination R-HSA-73928 9.035029e-01 0.044 0 0
Translation R-HSA-72766 9.038771e-01 0.044 0 0
Downstream TCR signaling R-HSA-202424 9.055258e-01 0.043 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.057206e-01 0.043 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.059364e-01 0.043 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.059364e-01 0.043 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.059364e-01 0.043 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.059364e-01 0.043 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.059364e-01 0.043 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.066594e-01 0.043 0 0
Trafficking of AMPA receptors R-HSA-399719 9.066594e-01 0.043 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.095656e-01 0.041 0 0
Interleukin-1 signaling R-HSA-9020702 9.123634e-01 0.040 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.143683e-01 0.039 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.143683e-01 0.039 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.155255e-01 0.038 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.155255e-01 0.038 0 0
PKA activation in glucagon signalling R-HSA-164378 9.155255e-01 0.038 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.155255e-01 0.038 0 0
PKA activation R-HSA-163615 9.155255e-01 0.038 0 0
Apoptotic factor-mediated response R-HSA-111471 9.155255e-01 0.038 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.210660e-01 0.036 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.214762e-01 0.036 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.214762e-01 0.036 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.214762e-01 0.036 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.214762e-01 0.036 0 0
HCMV Early Events R-HSA-9609690 9.218314e-01 0.035 0 0
Leishmania infection R-HSA-9658195 9.221608e-01 0.035 0 0
Parasitic Infection Pathways R-HSA-9824443 9.221608e-01 0.035 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.230509e-01 0.035 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.241375e-01 0.034 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.241375e-01 0.034 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.241375e-01 0.034 0 0
Specification of the neural plate border R-HSA-9834899 9.241375e-01 0.034 0 0
Translesion Synthesis by POLH R-HSA-110320 9.241375e-01 0.034 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.241375e-01 0.034 0 0
Other interleukin signaling R-HSA-449836 9.241375e-01 0.034 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.241375e-01 0.034 0 0
HDL remodeling R-HSA-8964058 9.241375e-01 0.034 0 0
Maturation of nucleoprotein R-HSA-9694631 9.241375e-01 0.034 0 0
HCMV Infection R-HSA-9609646 9.247800e-01 0.034 0 0
Metabolism of porphyrins R-HSA-189445 9.253419e-01 0.034 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.280254e-01 0.032 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.280254e-01 0.032 0 0
PPARA activates gene expression R-HSA-1989781 9.286148e-01 0.032 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.314691e-01 0.031 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.318721e-01 0.031 0 0
Creatine metabolism R-HSA-71288 9.318721e-01 0.031 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.330462e-01 0.030 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.339927e-01 0.030 0 0
eNOS activation R-HSA-203615 9.340559e-01 0.030 0 0
Signal amplification R-HSA-392518 9.340559e-01 0.030 0 0
Hyaluronan metabolism R-HSA-2142845 9.340559e-01 0.030 0 0
PLC beta mediated events R-HSA-112043 9.375899e-01 0.028 0 0
Aquaporin-mediated transport R-HSA-445717 9.375899e-01 0.028 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.388185e-01 0.027 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.388185e-01 0.027 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.388185e-01 0.027 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.388185e-01 0.027 0 0
GPER1 signaling R-HSA-9634597 9.389082e-01 0.027 0 0
Gluconeogenesis R-HSA-70263 9.389082e-01 0.027 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.413106e-01 0.026 0 0
Protein ubiquitination R-HSA-8852135 9.424359e-01 0.026 0 0
tRNA processing R-HSA-72306 9.424708e-01 0.026 0 0
Stimuli-sensing channels R-HSA-2672351 9.432859e-01 0.025 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.447093e-01 0.025 0 0
RNA Polymerase III Transcription R-HSA-74158 9.447093e-01 0.025 0 0
GPVI-mediated activation cascade R-HSA-114604 9.447093e-01 0.025 0 0
Glycosphingolipid transport R-HSA-9845576 9.447093e-01 0.025 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.450570e-01 0.025 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.450570e-01 0.025 0 0
Attachment and Entry R-HSA-9694614 9.450570e-01 0.025 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.473597e-01 0.023 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.494007e-01 0.023 0 0
Cleavage of the damaged purine R-HSA-110331 9.494007e-01 0.023 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.506597e-01 0.022 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.506597e-01 0.022 0 0
Ethanol oxidation R-HSA-71384 9.506597e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.506597e-01 0.022 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.506597e-01 0.022 0 0
ER-Phagosome pathway R-HSA-1236974 9.507577e-01 0.022 0 0
Meiotic recombination R-HSA-912446 9.516930e-01 0.022 0 0
Integrin cell surface interactions R-HSA-216083 9.528474e-01 0.021 0 0
Depurination R-HSA-73927 9.537106e-01 0.021 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.537106e-01 0.021 0 0
Base Excision Repair R-HSA-73884 9.537662e-01 0.021 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.547837e-01 0.020 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.553672e-01 0.020 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.553672e-01 0.020 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.556913e-01 0.020 0 0
Biosynthesis of maresins R-HSA-9018682 9.556913e-01 0.020 0 0
Nucleotide biosynthesis R-HSA-8956320 9.587784e-01 0.018 0 0
G-protein mediated events R-HSA-112040 9.594337e-01 0.018 0 0
Ion channel transport R-HSA-983712 9.594983e-01 0.018 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.602101e-01 0.018 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.602101e-01 0.018 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.602101e-01 0.018 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.602101e-01 0.018 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.618206e-01 0.017 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.619438e-01 0.017 0 0
Transmission across Chemical Synapses R-HSA-112315 9.626090e-01 0.017 1 0
Hyaluronan degradation R-HSA-2160916 9.642683e-01 0.016 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.642683e-01 0.016 0 0
Formation of the nephric duct R-HSA-9830364 9.642683e-01 0.016 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.646319e-01 0.016 0 0
G alpha (z) signalling events R-HSA-418597 9.648795e-01 0.016 0 0
Paracetamol ADME R-HSA-9753281 9.648795e-01 0.016 0 0
RSV-host interactions R-HSA-9833110 9.650045e-01 0.015 0 0
Interferon alpha/beta signaling R-HSA-909733 9.662018e-01 0.015 0 0
Mitochondrial protein degradation R-HSA-9837999 9.664565e-01 0.015 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.674725e-01 0.014 0 0
Ion homeostasis R-HSA-5578775 9.676007e-01 0.014 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.676869e-01 0.014 0 0
MET activates PTK2 signaling R-HSA-8874081 9.679129e-01 0.014 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.679129e-01 0.014 0 0
Metalloprotease DUBs R-HSA-5689901 9.679129e-01 0.014 0 0
Sphingolipid catabolism R-HSA-9845614 9.679129e-01 0.014 0 0
Gastrulation R-HSA-9758941 9.692181e-01 0.014 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.698039e-01 0.013 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.698039e-01 0.013 0 0
Dectin-2 family R-HSA-5621480 9.701219e-01 0.013 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.711858e-01 0.013 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.711858e-01 0.013 0 0
Synthesis of PE R-HSA-1483213 9.711858e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.711858e-01 0.013 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.727212e-01 0.012 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.730521e-01 0.012 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.741251e-01 0.011 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.741251e-01 0.011 0 0
Prednisone ADME R-HSA-9757110 9.741251e-01 0.011 0 0
Regulation of insulin secretion R-HSA-422356 9.758793e-01 0.011 0 0
Metabolism of steroids R-HSA-8957322 9.764206e-01 0.010 0 0
GABA receptor activation R-HSA-977443 9.766168e-01 0.010 0 0
tRNA Aminoacylation R-HSA-379724 9.766168e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.767648e-01 0.010 0 0
Platelet calcium homeostasis R-HSA-418360 9.767648e-01 0.010 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.775518e-01 0.010 0 0
SLC transporter disorders R-HSA-5619102 9.776971e-01 0.010 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.780087e-01 0.010 0 0
Hedgehog 'off' state R-HSA-5610787 9.789097e-01 0.009 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.791352e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.791352e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.804145e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.809068e-01 0.008 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.809068e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.812640e-01 0.008 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.812640e-01 0.008 0 0
Synthesis of PC R-HSA-1483191 9.813199e-01 0.008 0 0
Interferon gamma signaling R-HSA-877300 9.821883e-01 0.008 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.829661e-01 0.007 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.831757e-01 0.007 0 0
Xenobiotics R-HSA-211981 9.832121e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.848924e-01 0.007 0 0
Signaling by Hedgehog R-HSA-5358351 9.849456e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.857086e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.858011e-01 0.006 0 0
Amyloid fiber formation R-HSA-977225 9.859145e-01 0.006 0 0
Collagen formation R-HSA-1474290 9.867172e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.869466e-01 0.006 0 0
Kidney development R-HSA-9830369 9.869474e-01 0.006 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.878185e-01 0.005 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.878185e-01 0.005 0 0
Gap junction assembly R-HSA-190861 9.878185e-01 0.005 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.879526e-01 0.005 0 0
O-linked glycosylation of mucins R-HSA-913709 9.880044e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.890617e-01 0.005 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.911266e-01 0.004 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.911806e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.911806e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.911806e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.911806e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.911806e-01 0.004 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.914895e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.916363e-01 0.004 0 0
Digestion R-HSA-8935690 9.919227e-01 0.004 0 0
Elastic fibre formation R-HSA-1566948 9.920809e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.921673e-01 0.003 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.921673e-01 0.003 0 0
RAS processing R-HSA-9648002 9.928893e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.928893e-01 0.003 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.933109e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.936152e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.936152e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.939144e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.939144e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.942670e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.942670e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.948523e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.948523e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.948523e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.949167e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.949167e-01 0.002 0 0
Endogenous sterols R-HSA-211976 9.949658e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.949658e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.953779e-01 0.002 0 0
Mitochondrial protein import R-HSA-1268020 9.954224e-01 0.002 0 0
Digestion and absorption R-HSA-8963743 9.958383e-01 0.002 0 0
Defensins R-HSA-1461973 9.958499e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.962045e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.962415e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.962737e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.962737e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.962737e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.966039e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.971613e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.971613e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.971613e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.971854e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.975783e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.978256e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.978256e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.980433e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.980478e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.980683e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.980683e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.982462e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.982472e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.984810e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.985573e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.986342e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.987314e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.989200e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.990819e-01 0.000 0 0
Disease R-HSA-1643685 9.993374e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.993577e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.993866e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.994549e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995193e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.995684e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.995684e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.995940e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.996565e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996877e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997197e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997454e-01 0.000 0 0
Protein localization R-HSA-9609507 9.997650e-01 0.000 0 0
Hemostasis R-HSA-109582 9.997666e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997741e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.997965e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997972e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998157e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998179e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998194e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998203e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.998489e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998533e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998659e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998683e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998683e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998761e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998974e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998985e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999145e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999145e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999150e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999311e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999311e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999425e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999583e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999583e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999742e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999800e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999813e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999824e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999835e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999841e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999899e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999901e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999903e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999904e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999926e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999939e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999939e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999948e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999954e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999968e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999970e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999971e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999978e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999986e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999988e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999988e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999990e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999992e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999993e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999996e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999996e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999997e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 1 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 1 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways