JNK3

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0MZ66	S444	Sugiyama	SHTN1 KIAA1598	RPVNQTARPKTKPESSKGCEsAVDELKGILGtLNKSTSSRs
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0	Y1062	Sugiyama	POTEF A26C1B	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00151	S130	Sugiyama	PDLIM1 CLIM1 CLP36	PQEVLHIGsAHNRsAMPFtAsPAsSTTARVItNQyNNPAGL
O00151	S90	Sugiyama	PDLIM1 CLIM1 CLP36	IKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKMNLASEP
O00232	S335	Sugiyama	PSMD12	MRWSTLVEDYGMELRKGsLEsPAtDVFGsTEEGEKRWKDLK
O00429	S126	Sugiyama	DNM1L DLP1 DRP1	EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O14545	S327	Sugiyama	TRAFD1 FLN29	DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O14672	S630	Sugiyama	ADAM10 KUZ MADM	TGSVQWSRHFSGRTITLQPGsPCNDFRGYCDVFMRCRLVDA
O15085	S1452	Sugiyama	ARHGEF11 KIAA0380	LTLKLNRLKDMELAHRELLKsLGGEssGGttPVGSFHTEAA
O15085	S1457	Sugiyama	ARHGEF11 KIAA0380	NRLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDG
O15085	S1458	Sugiyama	ARHGEF11 KIAA0380	RLKDMELAHRELLKsLGGEssGGttPVGSFHTEAARWTDGs
O15372	S183	Sugiyama	EIF3H EIF3S3	SLKAYRLTPKLMEVCKEKDFsPEALKKANITFEYMFEEVPI
O43521	S59	SIGNOR\|EPSD	BCL2L11 BIM	EPQGNPEGNHGGEGDSCPHGsPQGPLAPPAsPGPFATRsPL
O43521	S69	SIGNOR\|EPSD	BCL2L11 BIM	GGEGDSCPHGsPQGPLAPPAsPGPFATRsPLFIFMRRSsLL
O43521	S77	SIGNOR	BCL2L11 BIM	HGsPQGPLAPPAsPGPFATRsPLFIFMRRSsLLSRsssGYF
O43521	T116	SIGNOR	BCL2L11 BIM	YFsFDTDRsPAPMSCDKSTQtPsPPCQAFNHYLSAMASMRQ
O43765	S77	Sugiyama	SGTA SGT SGT1	TLPEIFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTE
O43765	T81	Sugiyama	SGTA SGT SGT1	IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60271	T226	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	IFPLPAGDGLLtPDAQKGGEtPGsEQWKFQELsQPRsHtsL
O60282	S176	SIGNOR	KIF5C KIAA0531 NKHC2	VHEDKNRVPYVKGCTERFVSsPEEVMDVIDEGKANRHVAVT
O60333	T647	Sugiyama	KIF1B KIAA0591 KIAA1448	GKNHVFRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELL
O60333	T652	Sugiyama	KIF1B KIAA0591 KIAA1448	FRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELLEKQGI
O60568	S367	Sugiyama	PLOD3	WPQLQDHFSAVKLVGPEEALsPGEARDMAMDLCRQDPECEF
O60701	T185	Sugiyama	UGDH	EGTAIKDLKNPDRVLIGGDEtPEGQRAVQALCAVYEHWVPR
O75179	Y2038	Sugiyama	ANKRD17 GTAR KIAA0697	SNNNTAPTNATYPMPTAKEHyPVssPssPsPPAQPGGVsRN
O75391	S158	Sugiyama	SPAG7	LKELAQRQEEEAAQQGPVVVsPAsDyKDKYSHLIGKGAAKD
O75822	T109	Sugiyama	EIF3J EIF3S1 PRO0391	KKRQEEIKKRLEEPEEPKVLtPEEQLADKLRLKKLQEEsDL
O95067	S392	Sugiyama	CCNB2	KLLKISMIPQLNSKAVKDLAsPLIGRs______________
O95359	S2512	Sugiyama	TACC2	KQDYPQPSDLSTFVNETKFssPtEELDyRNsYEIEyMEKIG
O95644	S172	SIGNOR\|EPSD\|PSP	NFATC1 NFAT2 NFATC	PstATLSLPsLEAYRDPsCLsPAssLSSRSCNSEAsSYESN
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S319	Sugiyama	LDHA PIG19	GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00367	T409	Sugiyama	GLUD1 GLUD	TKSNAPRVKAKIIAEGANGPttPEADKIFLERNIMVIPDLY
P00367	T410	Sugiyama	GLUD1 GLUD	KSNAPRVKAKIIAEGANGPttPEADKIFLERNIMVIPDLYL
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P01106	S77	PSP	MYC BHLHE39	PPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVTPFsL
P01106	S86	PSP	MYC BHLHE39	KKFELLPtPPLsPsRRsGLCsPSyVAVTPFsLRGDNDGGGG
P01106	T73	PSP	MYC BHLHE39	SELQPPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVT
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05067	T743	GPS6\|SIGNOR	APP A4 AD1	LKKKQYtsIHHGVVEVDAAVtPEERHLSKMQQNGyENPtyK
P05198	T279	Sugiyama	EIF2S1 EIF2A	KEKIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAE
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05412	S63	SIGNOR	JUN	ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05412	S73	SIGNOR	JUN	LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt
P05787	S291	Sugiyama	KRT8 CYK8	ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733	S272	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06744	S455	Sugiyama	GPI	ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07686	T307	Sugiyama	HEXB HCC7	PEFDTPGHTLSWGKGQKDLLtPCySRQNKLDSFGPINPTLN
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07741	S30	Sugiyama	APRT	EQRIRsFPDFPTPGVVFRDIsPVLKDPASFRAAIGLLARHL
P07814	S886	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLFD
P07814	T737	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S391	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07942	S1237	Sugiyama	LAMB1	RETVDsVERKVSEIKDILAQsPAAEPLKNIGNLFEEAEKLI
P07942	T1141	Sugiyama	LAMB1	FWGDPDVECRACDCDPRGIEtPQCDQSTGQCVCVEGVEGPR
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S383	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	Y484	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08865	T97	Sugiyama	RPSA LAMBR LAMR1	IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG38	Y1062	Sugiyama	POTEI	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39	Y1025	Sugiyama	POTEJ	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P10809	S159	Sugiyama	HSPD1 HSP60	EIRRGVMLAVDAVIAELKKQsKPVttPEEIAQVAtIsANGD
P10809	S175	Sugiyama	HSPD1 HSP60	LKKQsKPVttPEEIAQVAtIsANGDKEIGNIIsDAMKKVGR
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P10809	T164	Sugiyama	HSPD1 HSP60	VMLAVDAVIAELKKQsKPVttPEEIAQVAtIsANGDKEIGN
P10809	T173	Sugiyama	HSPD1 HSP60	AELKKQsKPVttPEEIAQVAtIsANGDKEIGNIIsDAMKKV
P10809	T455	Sugiyama	HSPD1 HSP60	GIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLKIP
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P12270	S2155	Sugiyama	TPR	PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12277	T35	Sugiyama	CKB CKBB	PAEDEFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDD
P13639	S595	Sugiyama	EEF2 EF2	PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S552	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	KEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEPV
P14649	S87	Sugiyama	MYL6B MLC1SA	EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14866	S101	Sugiyama	HNRNPL HNRPL P/OKcl.14	GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15336	T69	Sugiyama	ATF2 CREB2 CREBP1	HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA
P15336	T71	Sugiyama	ATF2 CREB2 CREBP1	MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P16278	S434	Sugiyama	GLB1 ELNR1	GFVLYRTTLPQDCSNPAPLssPLNGVHDRAyVAVDGIPQGV
P16949	S25	Sugiyama	STMN1 C1orf215 LAP18 OP18	DIQVKELEKRAsGQAFELILsPRsKEsVPEFPLsPPKKKDL
P16949	S38	SIGNOR\|Sugiyama	STMN1 C1orf215 LAP18 OP18	QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17544	T51	Sugiyama	ATF7 ATFA	HEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELA
P17544	T53	Sugiyama	ATF7 ATFA	MTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELASS
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18669	S31	Sugiyama	PGAM1 PGAMA CDABP0006	HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P20618	S151	Sugiyama	PSMB1 PSC5	PYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASA
P21333	S1084	Sugiyama	FLNA FLN FLN1	PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22314	T233	Sugiyama	UBA1 A1S9T UBE1	GEQPLSAMVSMVTKDNPGVVtCLDEARHGFESGDFVSFSEV
P23921	S559	Sugiyama	RRM1 RR1	ALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNVTPTDLW
P24752	S218	Sugiyama	ACAT1 ACAT MAT	ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27816	S280	Sugiyama	MAP4	LAKDMALATKTEVALAKDMEsPtKLDVtLAKDMQPSMESDM
P28074	S175	Sugiyama	PSMB5 LMPX MB1 X	SMGTMICGWDKRGPGLyyVDsEGNRISGATFSVGSGSVYAY
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401	T287	Sugiyama	TKT	AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29692	S65	Sugiyama	EEF1D EF1D	VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29966	S27	Sugiyama	MARCKS MACS PRKCSL	KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P30041	T44	Sugiyama	PRDX6 AOP2 KIAA0106	RFHDFLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKR
P30043	S82	Sugiyama	BLVRB FLR SCAN	DKTVAGQDAVIVLLGTRNDLsPTTVMSEGARNIVAAMKAHG
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30050	S165	Sugiyama	RPL12	GRHPHDIIDDINsGAVECPAs____________________
P30050	S26	Sugiyama	RPL12	DPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDDI
P30101	S443	Sugiyama	PDIA3 ERP57 ERP60 GRP58	LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P30307	S168	SIGNOR	CDC25C	SANKENDNGNLVDSEMKYLGsPITTVPKLDKNPNLGEDQAE
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S186	SIGNOR	SFN HME1	NPIRLGLALNFSVFHYEIANsPEEAISLAKTtFDEAMADLH
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32969	Y180	Sugiyama	RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9	LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33316	Y167	Sugiyama	DUT	PPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDVGAG
P33992	S315	Sugiyama	MCM5 CDC46	RVLGIQVDTDGSGRSFAGAVsPQEEEEFRRLAALPNVYEVI
P34897	S417	Sugiyama	SHMT2	ERVLELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFR
P34897	T420	Sugiyama	SHMT2	LELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFREDD
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35606	T828	Sugiyama	COPB2	EEWVKETHADLWPAKQyPLVtPNEERNVMEEGKDFQPSRst
P35998	T193	Sugiyama	PSMC2 MSS1	TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P36578	S295	Sugiyama	RPL4 RPL1	sNyNLPMHKMINtDLsRILKsPEIQRALRAPRKKIHRRVLK
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38936	S130	EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	HVDLsLSCTLVPRsGEQAEGsPGGPGDSQGRKRRQtsMTDF
P38936	S98	EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	LPtGPRRGRDELGGGRRPGtsPALLQGTAEEDHVDLsLSCT
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43121	T107	Sugiyama	MCAM MUC18	EYEQRLsLQDRGAtLALtQVtPQDERIFLCQGKRPRSQEYR
P45983	S179	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	VKSDCTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILG
P45983	T178	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	VVKSDCTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVIL
P45983	T183	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P45983	T188	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	LDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKENVDL
P45983	T243	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	ILFPGRDYIDQWNKVIEQLGtPCPEFMKKLQPTVRTYVENR
P45983	Y185	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P45983	Y190	Sugiyama	MAPK8 JNK1 PRKM8 SAPK1 SAPK1C	FGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKENVDLWS
P45985	T60	Sugiyama	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	KRKALKLNFANPPFKstARFtLNPNPtGVQNPHIERLRTHs
P45985	T66	Sugiyama	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	LNFANPPFKstARFtLNPNPtGVQNPHIERLRTHsIEsSGK
P46013	T1923	Sugiyama	MKI67	AMHTPKAAVGEEKDINtFVGtPVEKLDLLGNLPGsKRRPQt
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937	S367	Sugiyama	YAP1 YAP65	ALRSQLPtLEQDGGtQNPVssPGMsQELRTMttNssDPFLN
P46937	T119	Sugiyama	YAP1 YAP65	PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P47756	S207	Sugiyama	CAPZB	MNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMENKIRst
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49023	S106	Sugiyama	PXN	PVyGssAKtssVsNPQDsVGsPCsRVGEEEHVysFPNKQKs
P49321	T390	Sugiyama	NASP	EAPVLPKDGAVNGPsVVGDQtPIEPQtsIERLtEtKDGsGL
P49327	S831	Sugiyama	FASN FAS	NPNALFPPVEFPAPRGtPLIsPLIKWDHSLAWDVPAAEDFP
P49327	T827	Sugiyama	FASN FAS	GIDANPNALFPPVEFPAPRGtPLIsPLIKWDHSLAWDVPAA
P49448	T409	Sugiyama	GLUD2 GLUDP1	TKSNAPRVKAKIIAEGANGPttPEADKIFLERNILVIPDLY
P49448	T410	Sugiyama	GLUD2 GLUDP1	KSNAPRVKAKIIAEGANGPttPEADKIFLERNILVIPDLYL
P49792	T1144	Sugiyama	RANBP2 NUP358	GFRRsDDMFTFHGPGKsVFGtPtLETANKNHEtDGGsAHGD
P50502	S181	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P51991	S358	Sugiyama	HNRNPA3 HNRPA3	QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P52565	T160	Sugiyama	ARHGDIA GDIA1	DKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYsIKSR
P52948	S623	Sugiyama	NUP98 ADAR2	KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53779	S217	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	VKSDCTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILG
P53779	T216	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	VVKSDCTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVIL
P53779	T221	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P53779	T226	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	LDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKENVDI
P53779	T281	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	ILFPGRDYIDQWNKVIEQLGtPCPEFMKKLQPTVRNYVENR
P53779	T308	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	KKLQPTVRNYVENRPKyAGLtFPKLFPDSLFPADSEHNKLK
P53779	Y223	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P53779	Y228	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	FGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKENVDIWS
P53779	Y304	Sugiyama	MAPK10 JNK3 JNK3A PRKM10 SAPK1B	PEFMKKLQPTVRNYVENRPKyAGLtFPKLFPDSLFPADSEH
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54259	S739	GPS6\|SIGNOR\|EPSD\|PSP	ATN1 D12S755E DRPLA	PPLSATQIKQEPAEEyEtPEsPVPPARsPsPPPKVVDVPSH
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55036	S115	Sugiyama	PSMD4 MCB1	LALKHRQGKNHKMRIIAFVGsPVEDNEKDLVKLAKRLKKEK
P55209	T62	Sugiyama	NAP1L1 NRP	MMQNPQILAALQERLDGLVEtPtGyIEsLPRVVKRRVNALK
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P55809	S509	Sugiyama	OXCT1 OXCT SCOT	LWEGLTVDDVQKSTGCDFAVsPKLMPMQQIAN_________
P55957	T59	EPSD\|PSP	BID	ALGHELPVLAPQWEGyDELQtDGNRssHsRLGRIEADsEsQ
P60660	S30	Sugiyama	MYL6	AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709	Y362	Sugiyama	ACTB	GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P60866	T6	Sugiyama	RPS20	_______________MAFKDtGKtPVEPEVAIHRIRITLTS
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P61604	S64	Sugiyama	HSPE1	AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P61916	S40	Sugiyama	NPC2 HE1	EPVQFKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVT
P61978	S216	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	HNRNPK HNRPK	GGKPDRVVECIKIILDLIsEsPIKGRAQPyDPNFyDETyDy
P61978	S284	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	HNRNPK HNRPK	MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P61978	S353	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	HNRNPK HNRPK	YDGMVGFSADETWDSAIDtWsPSEWQMAYEPQGGSGYDYSY
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62195	T109	Sugiyama	PSMC5 SUG1	VHPEGKFVVDVDKNIDINDVtPNCRVALRNDsytLHKILPN
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62714	S212	Sugiyama	PPP2CB	EGPMCDLLWSDPDDRGGWGIsPRGAGYTFGQDISETFNHAN
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750	Y144	Sugiyama	RPL23A	VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63104	S184	SIGNOR	YWHAZ	HPIRLGLALNFSVFYYEILNsPEKACSLAKtAFDEAIAELD
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261	Y362	Sugiyama	ACTG1 ACTG	GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67775	S212	Sugiyama	PPP2CA	EGPMCDLLWSDPDDRGGWGIsPRGAGYTFGQDISETFNHAN
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104	T261	Sugiyama	EEF1A1 EEF1A EF1A LENG7	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P78347	S210	Sugiyama	GTF2I BAP135 WBSCR6	EPKKHVGGRVMVtDADRsILsPGGsCGPIKVKTEPTEDSGI
P85037	S420	Sugiyama	FOXK1 MNF	RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037	S428	Sugiyama	FOXK1 MNF	PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q01082	S2197	Sugiyama	SPTBN1 SPTB2	KTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNKKA
Q01082	T2192	Sugiyama	SPTBN1 SPTB2	sDRKAKTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEA
Q01814	S1234	Sugiyama	ATP2B2 PMCA2	DSGINLTTDtsKSATSSsPGsPIHSLEtsL___________
Q04637	S1231	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	tEDRDRGRDAVKREAALPPVsPLKAALsEEELEKKsKAIIE
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639	T261	Sugiyama	EEF1A2 EEF1AL STN	PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q06481	T736	EPSD\|PSP	APLP2 APPL2	LRKRQYGtISHGIVEVDPMLtPEERHLNKMQNHGyENPtyK
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07866	S460	Sugiyama	KLC1 KLC KNS2	QKDGTsFGEyGGWyKACKVDsPtVTTtLKNLGALyRRQGKF
Q08AD1	S673	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	DASKFLQDyDIRTGNTREALsPCPsTVsTKSQPGSSAssss
Q08J23	S743	Sugiyama	NSUN2 SAKI TRM4	AstGQPDNDVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGV
Q08J23	S751	Sugiyama	NSUN2 SAKI TRM4	DVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGVHPPR____
Q09666	S216	Sugiyama	AHNAK PM227	DVEtQsGKtVIRLPsGsGAAsPtGsAVDIRAGAIsAsGPEL
Q09666	S41	Sugiyama	AHNAK PM227	HGLTIAQRDDGVFVQEVtQNsPAARTGVVKEGDQIVGATIy
Q09666	T4564	Sugiyama	AHNAK PM227	LEGDLKGPKVDVKGPKVGIDtPDIDIHGPEGKLKGPKFKMP
Q12931	S568	Sugiyama	TRAP1 HSP75 HSPC5	ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q13017	S968	Sugiyama	ARHGAP5 RHOGAP5	SYLsDNtRESTHQSEDVFLPsPRDCFPyNNyPDsDDDtEAP
Q13045	S856	Sugiyama	FLII FLIL	KNWDDVLTVDYTRNAEAVLQsPGLsGKVKRDAEKKDQMKAD
Q13066	T39	Sugiyama	GAGE2B GAGE2; GAGE2C	PPEMIGPMRPEQFsDEVEPAtPEEGEPATQRQDPAAAQEGE
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13409	T95	Sugiyama	DYNC1I2 DNCI2 DNCIC2	IVFSEYWVPPPMsPSSKsVStPsEAGsQDsGDGAVGsRTLH
Q13428	T1014	Sugiyama	TCOF1	ARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPRIAPK
Q13451	S13	Sugiyama	FKBP5 AIG6 FKBP51	________MttDEGAKNNEEsPtAtVAEQGEDITsKKDRGV
Q13459	S1308	Sugiyama	MYO9B MYR5	PDsPGGstQIQRYLDAERLAsAVELWRGKKLVAAAsPsAML
Q14103	S190	Sugiyama	HNRNPD AUF1 HNRPD	KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14103	T193	Sugiyama	HNRNPD AUF1 HNRPD	KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14160	S504	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14204	S2410	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	GEDEAQRRRKGKEDEGEEAAsPMLQIQRDAATIMQPYFTSN
Q14204	S3082	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	LHVVFTMNPSSEGLKDRAAtsPALFNRCVLNWFGDWSTEAL
Q14247	S418	Sugiyama	CTTN EMS1	KtQtPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVs
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14684	T708	Sugiyama	RRP1B KIAA0179	LNRNMtAEFKKTDKsILVsPtGPsRVAFDPEQKPLHGVLKt
Q14847	T104	Sugiyama	LASP1 MLN50	VRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsNIKyHE
Q14980	S1757	Sugiyama	NUMA1 NMP22 NUMA	ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15393	T1200	Sugiyama	SF3B3 KIAA0017 SAP130	EQFNsMEPNKQKNVSEELDRtPPEVSKKLEDIRTRYAF___
Q15545	S201	Sugiyama	TAF7 TAF2F TAFII55	WEIIAEDETKEAENQGLDIssPGMsGHRQGHDsLEHDELRE
Q15637	S80	Sugiyama	SF1 ZFM1 ZNF162	DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15642	S298	Sugiyama	TRIP10 CIP4 STOT STP	RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT
Q15773	S238	Sugiyama	MLF2	GAGGRRAEGPPRLAIQGPEDsPsRQsRRYDW__________
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16600	S129	GPS6	ZNF239 HOK2 MOK2	GESCSENLQVKLVSDGQELAsPLLNGEATCQNGQLKESLDP
Q16600	S38	GPS6	ZNF239 HOK2 MOK2	EVDGEPELDIsPCQQWGEAssPISRNRDsVMTLQSGCFENI
Q16643	T346	Sugiyama	DBN1 D0S117E	RRMAPtPIPtRsPsDsstAstPVAEQIERALDEVTsSQPPP
Q16881	T413	Sugiyama	TXNRD1 GRIM12 KDRF	HGIKFIRQFVPIKVEQIEAGtPGRLRVVAQSTNSEEIIEGE
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF8	Y260	Sugiyama	HSP90AB2P HSP90BB	VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q5JR12	S93	SIGNOR	PPM1J PPP2CZ	LQLsPGGLRRADDHAGRAVQsPPDTGRRLPWSTGYAEVINA
Q5JSH3	S96	Sugiyama	WDR44 RPH11	QLEDDsLDSKGKELsDQAtAsPIVARTDLSNIPGLLAIDQV
Q5R3I4	S362	Sugiyama	TTC38	GAHDPQTTQELLTTLRDASEsPGENCQHLLARDVGLPLCQA
Q5T4S7	S178	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q5T4S7	S181	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	PQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLTSVF
Q5VT52	T723	Sugiyama	RPRD2 KIAA0460 HSPC099	SHPSDFQRGPtstsIDNIDGtPVRDERsGtPtQDEMMDKPt
Q5VTE0	T261	Sugiyama	EEF1A1P5 EEF1AL3	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q66K74	S759	Sugiyama	MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1	LVsPCEFEHRKAVPMAPAPAsPGssNDssARsQERAGGLGA
Q6EMK4	S322	Sugiyama	VASN SLITL2 UNQ314/PRO357/PRO1282	CVCPLSWFGPWVRESHVTLAsPEETRCHFPPKNAGRLLLEL
Q6NT46	T39	Sugiyama	GAGE2A GAGE2	PPEMIGPMRPEQFsDEVEPAtPEEGEPATQRQDPAAAQEGQ
Q6NZY4	S598	Sugiyama	ZCCHC8	LDEPEVPEIFTKKsEAGHAssPDsEVTsLCQKEKAELAPVN
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3	Y1062	Sugiyama	POTEE A26C1A POTE2	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6XQN6	S513	Sugiyama	NAPRT FHIP NAPRT1	SRALAQLsLSRLSPEHRRLRsPAQYQVVLSERLQALVNSLC
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7L2J0	S216	Sugiyama	MEPCE BCDIN3	NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0	S217	Sugiyama	MEPCE BCDIN3	LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417	S692	Sugiyama	NUFIP2 KIAA1321 PIG1	IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q7Z5K2	T388	Sugiyama	WAPL FOE KIAA0261 WAPAL	VCNVTIQDTMERsMDEFTAstPADLGEAGRLRKKADIATSK
Q7Z6Z7	T2889	Sugiyama	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	EAVGDTSAAGSSEQPRAGsstPGDAPPAVAEVQGRSDGsGE
Q86UE4	T143	Sugiyama	MTDH AEG1 LYRIC	SEKPKPNGRTVEVAEGEAVRtPQsVtAKQPPEIDKKNEKSK
Q8N1F7	S430	Sugiyama	NUP93 KIAA0095	TEDYLWLKLNQVCFDDDGTssPQDRLTLsQFQKQLLEDYGE
Q8N556	S265	Sugiyama	AFAP1 AFAP	KEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssDG
Q8N684	S205	Sugiyama	CPSF7	IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ7	T278	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	IDtADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPP
Q8NEY1	S1000	Sugiyama	NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1	PsPPALPMSLSAKGQLTNIVsPtAAttPRITRsNsIPTHEA
Q8NEY1	T1006	Sugiyama	NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1	PMSLSAKGQLTNIVsPtAAttPRITRsNsIPTHEAAFELYS
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NFI4	S181	Sugiyama	ST13P5 FAM10A5	LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8TB72	S82	Sugiyama	PUM2 KIAA0235 PUMH2	MVQRRsGQGFHGNsEVNAILsPRsEsGGLGVsMVEYVLsss
Q8TCS8	S754	Sugiyama	PNPT1 PNPASE	KYFGRDPADGRMRLSRKVLQsPAtTVVRTLNDRssIVMGEP
Q8WUF5	S567	Sugiyama	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	ISRLFHRHGGPGPGGPEPELsPItEGSEARAGPPAPAPPAP
Q8WUI4	S109	Sugiyama	HDAC7 HDAC7A	LAEVILKKQQAALERtVHPNsPGIPYRTLEPLETEGATRSM
Q8WWM7	S111	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q8WXI9	S135	Sugiyama	GATAD2B KIAA1150	ERGRLtPsPDIIVLsDNEAssPRsSsRMEERLKAANLEMFK
Q8WXI9	T120	Sugiyama	GATAD2B KIAA1150	INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q92530	S152	Sugiyama	PSMF1	SRIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIP
Q92530	S153	Sugiyama	PSMF1	RIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIPP
Q92688	S104	Sugiyama	ANP32B APRIL PHAPI2	AEKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCE
Q92688	T105	Sugiyama	ANP32B APRIL PHAPI2	EKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCEV
Q92945	S184	Sugiyama	KHSRP FUBP2	GEQINKIQQDSGCKVQIsPDsGGLPERsVsLtGAPEsVQKA
Q93045	S62	SIGNOR	STMN2 SCG10 SCGN10	VKQINKRAsGQAFELILKPPsPISEAPRTLAsPKKKDLsLE
Q93045	S73	SIGNOR	STMN2 SCG10 SCGN10	AFELILKPPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEE
Q969R2	S762	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	AHYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSA
Q969R2	S763	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	HYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAK
Q969R2	S766	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	LSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLW
Q969R2	S768	PSP	OSBP2 KIAA1664 ORP4 OSBPL4	GSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLWKK
Q96AE4	S140	Sugiyama	FUBP1	GEQISRIQQESGCKIQIAPDsGGLPERsCMLtGtPESVQSA
Q96AE4	S630	Sugiyama	FUBP1	DYSAAWAEYYRQQAAyyAQtsPQGMPQHPPAPQGQ______
Q96AG4	S47	Sugiyama	LRRC59 PRO1855	LNEVPVKELAALPKATILDLsCNKLTTLPSDFCGLtHLVKL
Q96B36	S212	Sugiyama	AKT1S1 PRAS40	GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D15	T72	Sugiyama	RCN3 UNQ239/PRO272	FQYDHEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGD
Q96G03	S186	Sugiyama	PGM2 MSTP006	HNPKQDNGYKVyWDNGAQIIsPHDKGISQAIEENLEPWPQA
Q96HE7	S143	Sugiyama	ERO1A ERO1L UNQ434/PRO865	EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96K76	S910	Sugiyama	USP47	DGDNGDssKstEtsDFENIEsPLNERDsSAsVDNRELEQHI
Q9BQ16	T118	Sugiyama	SPOCK3 TICN3 UNQ409/PRO771	HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9BX68	T47	Sugiyama	HINT2	QVRGAAGVTDGNEVAKAQQAtPGGAAPtIFsRILDKsLPAD
Q9BYN0	T133	Sugiyama	SRXN1 C20orf139 SRX SRX1	IPAKLVQSTLSDLRVYLGAStPDLQ________________
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7	Y362	Sugiyama	POTEKP ACTBL3 FKSG30	GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S1297	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GQADWtPDLGLRNMAPGAVCsPGEsKELGVGQMDWGNNLGL
Q9C0C2	S435	Sugiyama	TNKS1BP1 KIAA1741 TAB182	DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2	S494	Sugiyama	TNKS1BP1 KIAA1741 TAB182	QSFEWTFPTRPSGLGVWRLDsPPPsPItEAsEAAEAAEAGN
Q9C0C2	S498	Sugiyama	TNKS1BP1 KIAA1741 TAB182	WTFPTRPSGLGVWRLDsPPPsPItEAsEAAEAAEAGNLAVS
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9C0C2	S712	Sugiyama	TNKS1BP1 KIAA1741 TAB182	PPPsGGGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEF
Q9C0C2	S717	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEFGITGD
Q9C0C2	T715	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sGGGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEFGIT
Q9H078	S668	Sugiyama	CLPB SKD3	TLRITVEDSDKQLLKsPELPsPQAEKRLPKLRLEIIDKDSK
Q9H0B6	S445	Sugiyama	KLC2	RRDsAPyGEyGsWYKACKVDsPtVNTTLRSLGALYRRQGKL
Q9H0L4	T570	Sugiyama	CSTF2T KIAA0689	GASKQGGsQPssFsPGQsQVtPQDQEKAALIMQVLQLTADQ
Q9H2U2	S313	Sugiyama	PPA2 HSPC124	VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H6F5	S80	Sugiyama	CCDC86 CYCLON	ERPPKtsPGsPRLQQGAGLEsPQGQPEPGAAsPQRQQDLHL
Q9H8Y8	S432	Sugiyama	GORASP2 GOLPH6	VDVtPPtAKAPttVEDRVGDstPVsEKPVsAAVDANAsEsP
Q9H8Y8	S441	Sugiyama	GORASP2 GOLPH6	APttVEDRVGDstPVsEKPVsAAVDANAsEsP_________
Q9HBL0	S858	Sugiyama	TNS1 TNS	NMLMLDLEPASAAAPLHKSQsVPGAWPGASPLSSQPLSGSS
Q9HCD6	S169	Sugiyama	TANC2 KIAA1148 KIAA1636	tLPPISTNATAKDCSyGAVtsPtstLESRDSGIIATLTSYS
Q9HDC9	T190	Sugiyama	APMAP C20orf3 UNQ1869/PRO4305	KGLFEVNPWKREVKLLLSsEtPIEGKNMSFVNDLTVTQDGR
Q9NPI6	S523	Sugiyama	DCP1A SMIF	APSVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILS
Q9NPI6	T528	Sugiyama	DCP1A SMIF	QQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKsQLQ
Q9NPI6	T531	Sugiyama	DCP1A SMIF	VTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKsQLQDTL
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NSK0	S460	Sugiyama	KLC4 KNSL8	HEGGtPYAEYGGWYKACKVssPTVNTTLRNLGALyRRQGKL
Q9NZB2	S990	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	FPLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKN
Q9NZT2	S378	Sugiyama	OGFR	LERsQGDEAGGHGEDRPEPLsPKEsKKRKLELSRREQPPTE
Q9P2J9	S118	Sugiyama	PDP2 KIAA1348	LESRVPNSVLRFESNQLAANsPVEDRRGVASCLQTNGLMFG
Q9UGV2	S361	Sugiyama	NDRG3	sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UHB6	S490	Sugiyama	LIMA1 EPLIN SREBP3 PP624	ENEEILERPAQLANAREtPHsPGVEDAPIAKVGVLAAsMEA
Q9UKS6	S319	Sugiyama	PACSIN3	FEEWsLDtQRtIsRKEKGGRsPDEVtLtsIVPTRDGTAPPP
Q9ULD2	S1264	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	RsPtssAIPLQsPRNsGsFPsPsIsPR______________
Q9ULD2	S1268	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ssAIPLQsPRNsGsFPsPsIsPR__________________
Q9UPT6	T265	SIGNOR\|iPTMNet	MAPK8IP3 JIP3 KIAA1066	SSYQCPQDEMSESGQSSAAAtPSTTGTKsNtPtssVPSAAV
Q9UPT6	T275	SIGNOR\|iPTMNet	MAPK8IP3 JIP3 KIAA1066	SESGQSSAAAtPSTTGTKsNtPtssVPSAAVtPLNESLQPL
Q9UPT6	T286	SIGNOR\|iPTMNet	MAPK8IP3 JIP3 KIAA1066	PSTTGTKsNtPtssVPSAAVtPLNESLQPLGDYGVGSKNSK
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2272	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tAVNLADsRtPAAAAAMNLAsPRtAVAPsAVNLADPRtPtA
Q9UQ35	T383	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	PPAPtPLLAERHGGsPQPLAttPLsQEPVNPPsEAsPtRDR
Q9UQF2	T103	GPS6	MAPK8IP1 IB1 JIP1 PRKM8IP	AGSRLQAEMLQMDLIDATGDtPGAEDDEEDDDEERAARRPG
Q9UQF2	T205	GPS6	MAPK8IP1 IB1 JIP1 PRKM8IP	KHSWQDRVSRSSsPLKTGEQtPPHEHICLSDELPPQSGPAP
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2	S41	Sugiyama	CARHSP1	LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2W2	S237	Sugiyama	WBP11 NPWBP SIPP1 SNP70	RKVGFALDLPPRRRDEDMLysPELAQRGHDDDVSSTSEDDG
Q9Y2X7	S362	Sugiyama	GIT1	TLIIDILSEAKRRQQGKsLssPtDNLELsLRSQSDLDDQHD
Q9Y5M8	S257	Sugiyama	SRPRB PSEC0230	LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Q9Y6G9	S516	Sugiyama	DYNC1LI1 DNCLI1	HAELDRITRKPVtVsPttPtsPtEGEAs_____________

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Chromatin organization	R-HSA-4839726	2.935932e-07	6.532	0	0
Chromatin modifying enzymes	R-HSA-3247509	4.158156e-06	5.381	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.237655e-06	5.205	0	0
Signal Transduction	R-HSA-162582	1.048046e-05	4.980	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.404918e-05	4.130	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	9.772664e-05	4.010	0	0
Cellular Senescence	R-HSA-2559583	9.855458e-05	4.006	1	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.598963e-04	3.796	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.691800e-04	3.772	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	2.256836e-04	3.647	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.256836e-04	3.647	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.236468e-04	3.650	0	0
Repression of WNT target genes	R-HSA-4641265	2.518368e-04	3.599	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.870135e-04	3.542	0	0
Signaling by NTRKs	R-HSA-166520	3.140371e-04	3.503	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.184851e-04	3.378	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.148591e-04	3.288	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.086220e-04	3.294	0	0
Gene expression (Transcription)	R-HSA-74160	5.243926e-04	3.280	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	7.003654e-04	3.155	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.913415e-04	3.050	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.932193e-04	3.049	0	0
ESR-mediated signaling	R-HSA-8939211	8.359312e-04	3.078	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	8.622467e-04	3.064	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.363181e-03	2.865	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.485411e-03	2.828	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.331371e-03	2.876	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.033697e-03	2.986	0	0
CREB phosphorylation	R-HSA-199920	1.485411e-03	2.828	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.066221e-03	2.972	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.628662e-03	2.788	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.631214e-03	2.787	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.596382e-03	2.797	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.760205e-03	2.754	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.366943e-03	2.626	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.366943e-03	2.626	0	0
RET signaling	R-HSA-8853659	2.452703e-03	2.610	0	0
Nervous system development	R-HSA-9675108	2.681948e-03	2.572	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.536593e-03	2.451	1	1
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.670453e-03	2.435	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.787589e-03	2.422	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.166054e-03	2.380	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.253813e-03	2.371	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.252764e-03	2.371	0	0
Cell Cycle	R-HSA-1640170	4.451670e-03	2.351	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.346227e-03	2.362	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.460207e-03	2.351	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.414356e-03	2.266	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.414356e-03	2.266	0	0
Generic Transcription Pathway	R-HSA-212436	5.340771e-03	2.272	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.450019e-03	2.264	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.733939e-03	2.242	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.492217e-03	2.260	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.492217e-03	2.260	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.181874e-03	2.209	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	6.866208e-03	2.163	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	6.866208e-03	2.163	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.932545e-03	2.159	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.932545e-03	2.159	0	0
TGFBR3 expression	R-HSA-9839394	6.866208e-03	2.163	0	0
HDMs demethylate histones	R-HSA-3214842	6.866208e-03	2.163	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.741787e-03	2.171	0	0
Nuclear import of Rev protein	R-HSA-180746	7.027683e-03	2.153	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	7.069507e-03	2.151	0	0
Signaling by WNT	R-HSA-195721	7.653845e-03	2.116	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	7.672798e-03	2.115	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.296014e-03	2.081	0	0
Activation of RAC1	R-HSA-428540	8.940223e-03	2.049	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	9.326852e-03	2.030	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.326852e-03	2.030	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.110723e-02	1.954	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	1.110723e-02	1.954	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	1.110723e-02	1.954	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.834810e-03	2.007	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.006682e-02	1.997	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.834810e-03	2.007	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.048219e-02	1.980	0	0
Signaling by LTK	R-HSA-9842663	1.110723e-02	1.954	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.128518e-02	1.947	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.144841e-02	1.941	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.155894e-02	1.937	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.231528e-02	1.910	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.347789e-02	1.870	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.347789e-02	1.870	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.346626e-02	1.871	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.283177e-02	1.892	0	0
Signaling by ALK	R-HSA-201556	1.259069e-02	1.900	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.353732e-02	1.868	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.353732e-02	1.868	0	0
Axon guidance	R-HSA-422475	1.390931e-02	1.857	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.400147e-02	1.854	0	0
HIV Life Cycle	R-HSA-162587	1.432646e-02	1.844	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.527684e-02	1.816	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.527684e-02	1.816	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.560058e-02	1.807	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.590778e-02	1.798	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.552179e-02	1.809	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.685770e-02	1.773	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.920859e-02	1.717	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.920859e-02	1.717	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.962635e-02	1.707	0	0
Signaling by FGFR2	R-HSA-5654738	2.126740e-02	1.672	0	0
Signaling by MET	R-HSA-6806834	2.126740e-02	1.672	0	0
Signaling by FGFR4	R-HSA-5654743	2.078079e-02	1.682	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.141150e-02	1.669	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.048962e-02	1.688	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.141150e-02	1.669	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.013046e-02	1.696	0	0
RSK activation	R-HSA-444257	2.158818e-02	1.666	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.228863e-02	1.652	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.277940e-02	1.642	0	0
NRAGE signals death through JNK	R-HSA-193648	2.289782e-02	1.640	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	2.478886e-02	1.606	0	0
MAPK family signaling cascades	R-HSA-5683057	2.483767e-02	1.605	0	0
Signaling by FGFR3	R-HSA-5654741	2.490688e-02	1.604	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.519233e-02	1.599	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.631579e-02	1.580	0	0
snRNP Assembly	R-HSA-191859	2.889313e-02	1.539	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.889313e-02	1.539	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.889313e-02	1.539	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.757733e-02	1.559	0	0
Signalling to ERKs	R-HSA-187687	2.631579e-02	1.580	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.902594e-02	1.537	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.942514e-02	1.531	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.953607e-02	1.530	0	0
Myogenesis	R-HSA-525793	2.953607e-02	1.530	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.303089e-02	1.481	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.303089e-02	1.481	0	0
Signaling by ERBB2	R-HSA-1227986	3.111137e-02	1.507	0	0
Signal attenuation	R-HSA-74749	3.299867e-02	1.482	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.323756e-02	1.478	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.111137e-02	1.507	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.191332e-02	1.496	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.303089e-02	1.481	0	0
Mitotic Prophase	R-HSA-68875	2.980659e-02	1.526	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.299867e-02	1.482	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.303089e-02	1.481	0	0
MAP kinase activation	R-HSA-450294	3.344346e-02	1.476	1	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.359232e-02	1.474	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.371869e-02	1.472	0	0
Regulation of gap junction activity	R-HSA-191650	4.120938e-02	1.385	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.120938e-02	1.385	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.120938e-02	1.385	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.120938e-02	1.385	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	3.966796e-02	1.402	0	0
Ephrin signaling	R-HSA-3928664	3.565134e-02	1.448	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.677257e-02	1.434	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.677257e-02	1.434	0	0
HIV elongation arrest and recovery	R-HSA-167287	3.677257e-02	1.434	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	3.677257e-02	1.434	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.076429e-02	1.390	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.500844e-02	1.347	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.167161e-02	1.380	0	0
IGF1R signaling cascade	R-HSA-2428924	4.114401e-02	1.386	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	4.076429e-02	1.390	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	4.500844e-02	1.347	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.395195e-02	1.357	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	4.529869e-02	1.344	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.120938e-02	1.385	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.120938e-02	1.385	0	0
Cell Cycle Checkpoints	R-HSA-69620	4.529513e-02	1.344	0	0
HATs acetylate histones	R-HSA-3214847	3.610497e-02	1.442	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.120938e-02	1.385	0	0
tRNA processing in the nucleus	R-HSA-6784531	3.589159e-02	1.445	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.321740e-02	1.364	0	0
FLT3 Signaling	R-HSA-9607240	4.529869e-02	1.344	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.076429e-02	1.390	1	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.167161e-02	1.380	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.529869e-02	1.344	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.966796e-02	1.402	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.823328e-02	1.418	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	5.177119e-02	1.286	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	5.177119e-02	1.286	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.177119e-02	1.286	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	4.696447e-02	1.328	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.487148e-02	1.261	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.487148e-02	1.261	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	5.425993e-02	1.266	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.911640e-02	1.309	0	0
HIV Transcription Initiation	R-HSA-167161	4.911640e-02	1.309	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.911640e-02	1.309	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.692893e-02	1.329	0	0
Transcription of the HIV genome	R-HSA-167172	5.312143e-02	1.275	0	0
MET activates RAS signaling	R-HSA-8851805	5.487148e-02	1.261	0	0
Interleukin-15 signaling	R-HSA-8983432	5.487148e-02	1.261	0	0
Adipogenesis	R-HSA-9843745	5.442954e-02	1.264	0	0
DNA Double Strand Break Response	R-HSA-5693606	4.993929e-02	1.302	0	0
Signalling to RAS	R-HSA-167044	5.158309e-02	1.287	0	0
Intracellular signaling by second messengers	R-HSA-9006925	5.275497e-02	1.278	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.318384e-02	1.274	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.487148e-02	1.261	0	0
Rab regulation of trafficking	R-HSA-9007101	5.099769e-02	1.292	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.158309e-02	1.287	0	0
L1CAM interactions	R-HSA-373760	4.870088e-02	1.312	0	0
ERK/MAPK targets	R-HSA-198753	5.158309e-02	1.287	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.336712e-02	1.273	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.700222e-02	1.328	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.425993e-02	1.266	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	5.732917e-02	1.242	0	0
TBC/RABGAPs	R-HSA-8854214	5.732917e-02	1.242	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.762771e-02	1.239	0	0
Signaling by EGFR	R-HSA-177929	5.763275e-02	1.239	0	0
Signaling by FGFR1	R-HSA-5654736	5.763275e-02	1.239	0	0
Interleukin-17 signaling	R-HSA-448424	5.986824e-02	1.223	1	0
Cyclin D associated events in G1	R-HSA-69231	6.172598e-02	1.210	0	0
G1 Phase	R-HSA-69236	6.172598e-02	1.210	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	6.336887e-02	1.198	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	6.336887e-02	1.198	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	6.336887e-02	1.198	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.336887e-02	1.198	0	0
Formation of axial mesoderm	R-HSA-9796292	6.336887e-02	1.198	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.346880e-02	1.197	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.346880e-02	1.197	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.554198e-02	1.183	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.631687e-02	1.178	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	6.631687e-02	1.178	0	0
Membrane Trafficking	R-HSA-199991	6.675894e-02	1.175	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.243376e-02	1.140	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.243376e-02	1.140	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.204100e-02	1.086	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.204100e-02	1.086	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.079681e-02	1.150	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.079681e-02	1.150	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.790951e-02	1.108	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.081924e-02	1.150	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.366708e-02	1.077	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.581568e-02	1.120	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.491302e-02	1.125	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.581568e-02	1.120	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.243376e-02	1.140	0	0
Oncogene Induced Senescence	R-HSA-2559585	7.581568e-02	1.120	0	0
Signaling by FGFR	R-HSA-190236	6.981289e-02	1.156	0	0
Signaling by NOTCH1	R-HSA-1980143	8.321690e-02	1.080	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.368850e-02	1.077	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.243376e-02	1.140	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.790951e-02	1.108	0	0
Neurodegenerative Diseases	R-HSA-8863678	7.790951e-02	1.108	0	0
Kinesins	R-HSA-983189	7.407516e-02	1.130	0	0
DCC mediated attractive signaling	R-HSA-418885	8.204100e-02	1.086	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	6.713066e-02	1.173	0	0
NGF-stimulated transcription	R-HSA-9031628	8.125078e-02	1.090	0	0
Signaling by TGFBR3	R-HSA-9839373	7.110171e-02	1.148	0	0
Regulation of KIT signaling	R-HSA-1433559	7.243376e-02	1.140	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.110171e-02	1.148	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.981289e-02	1.156	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.981289e-02	1.156	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.981289e-02	1.156	1	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.095668e-02	1.149	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.437760e-02	1.074	1	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.661280e-02	1.062	0	0
Negative regulation of FLT3	R-HSA-9706369	9.216359e-02	1.035	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	9.216359e-02	1.035	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	9.216442e-02	1.035	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.315296e-02	1.031	0	0
MET promotes cell motility	R-HSA-8875878	9.459976e-02	1.024	0	0
PTK6 Expression	R-HSA-8849473	9.988153e-02	1.001	0	0
SOS-mediated signalling	R-HSA-112412	9.988153e-02	1.001	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.008651e-01	0.996	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.008651e-01	0.996	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.008651e-01	0.996	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.008651e-01	0.996	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.008651e-01	0.996	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.008651e-01	0.996	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.012653e-01	0.995	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.013421e-01	0.994	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.013421e-01	0.994	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.013421e-01	0.994	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	1.026744e-01	0.989	0	0
Deubiquitination	R-HSA-5688426	1.027071e-01	0.988	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.027731e-01	0.988	0	0
mRNA 3'-end processing	R-HSA-72187	1.038281e-01	0.984	0	0
Gene Silencing by RNA	R-HSA-211000	1.073774e-01	0.969	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.083174e-01	0.965	0	0
HIV Transcription Elongation	R-HSA-167169	1.083174e-01	0.965	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.083174e-01	0.965	0	0
Cellular response to heat stress	R-HSA-3371556	1.105987e-01	0.956	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.116684e-01	0.952	1	0
PI3K events in ERBB2 signaling	R-HSA-1963642	1.138402e-01	0.944	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	1.138402e-01	0.944	0	0
HIV Infection	R-HSA-162906	1.151117e-01	0.939	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.160553e-01	0.935	1	0
Formation of annular gap junctions	R-HSA-196025	1.168548e-01	0.932	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.168548e-01	0.932	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.168548e-01	0.932	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	1.474200e-01	0.831	0	0
Defective VWF binding to collagen type I	R-HSA-9845622	1.474200e-01	0.831	0	0
Gap junction degradation	R-HSA-190873	1.344845e-01	0.871	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.526572e-01	0.816	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.494823e-01	0.825	0	0
Signaling by Erythropoietin	R-HSA-9006335	1.184187e-01	0.927	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.184187e-01	0.927	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.274365e-01	0.895	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.274365e-01	0.895	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.561023e-01	0.807	0	0
FOXO-mediated transcription	R-HSA-9614085	1.366855e-01	0.864	0	0
mRNA Capping	R-HSA-72086	1.184187e-01	0.927	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.561023e-01	0.807	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.344845e-01	0.871	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.253346e-01	0.902	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.297066e-01	0.887	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.462915e-01	0.835	0	0
PTEN Regulation	R-HSA-6807070	1.331400e-01	0.876	0	0
HDACs deacetylate histones	R-HSA-3214815	1.226845e-01	0.911	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.508012e-01	0.822	0	0
M Phase	R-HSA-68886	1.344776e-01	0.871	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	1.474200e-01	0.831	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	1.526572e-01	0.816	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	1.372256e-01	0.863	0	0
Co-inhibition by PD-1	R-HSA-389948	1.293063e-01	0.888	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.293063e-01	0.888	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.259659e-01	0.900	0	0
Oligomerization of connexins into connexons	R-HSA-190704	1.474200e-01	0.831	0	0
Breakdown of the nuclear lamina	R-HSA-352238	1.474200e-01	0.831	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	1.472890e-01	0.832	0	0
Signal transduction by L1	R-HSA-445144	1.494823e-01	0.825	0	0
Polo-like kinase mediated events	R-HSA-156711	1.253346e-01	0.902	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.381102e-01	0.860	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.561023e-01	0.807	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.344845e-01	0.871	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.345457e-01	0.871	1	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.253346e-01	0.902	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.366855e-01	0.864	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.915671e-01	0.718	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.915671e-01	0.718	0	0
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	1.915671e-01	0.718	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.915671e-01	0.718	0	0
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.915671e-01	0.718	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.915671e-01	0.718	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	1.915671e-01	0.718	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.915671e-01	0.718	0	0
Axonal growth stimulation	R-HSA-209563	2.334308e-01	0.632	0	0
MET activates PTPN11	R-HSA-8865999	2.334308e-01	0.632	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.334308e-01	0.632	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.334308e-01	0.632	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.731290e-01	0.564	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.731290e-01	0.564	0	0
Signaling by MAP2K mutants	R-HSA-9652169	2.731290e-01	0.564	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.731290e-01	0.564	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.712696e-01	0.766	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.712696e-01	0.766	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.712696e-01	0.766	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.107736e-01	0.508	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.107736e-01	0.508	0	0
NrCAM interactions	R-HSA-447038	3.107736e-01	0.508	0	0
IRS activation	R-HSA-74713	3.107736e-01	0.508	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.107736e-01	0.508	0	0
G2 Phase	R-HSA-68911	3.107736e-01	0.508	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	3.107736e-01	0.508	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	3.107736e-01	0.508	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	3.107736e-01	0.508	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.902277e-01	0.721	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.902277e-01	0.721	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.094460e-01	0.679	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.094460e-01	0.679	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.094460e-01	0.679	0	0
GRB2 events in EGFR signaling	R-HSA-179812	2.094460e-01	0.679	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.094460e-01	0.679	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.094460e-01	0.679	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.094460e-01	0.679	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.094460e-01	0.679	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.464708e-01	0.460	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.464708e-01	0.460	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.464708e-01	0.460	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.464708e-01	0.460	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.464708e-01	0.460	0	0
Phosphorylation of Emi1	R-HSA-176417	3.464708e-01	0.460	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.464708e-01	0.460	0	0
Signaling by RNF43 mutants	R-HSA-5340588	3.464708e-01	0.460	0	0
Signaling by MAPK mutants	R-HSA-9652817	3.464708e-01	0.460	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.620741e-01	0.790	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	1.749701e-01	0.757	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.483597e-01	0.605	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.483597e-01	0.605	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.803211e-01	0.420	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.803211e-01	0.420	0	0
Signaling by LTK in cancer	R-HSA-9842640	3.803211e-01	0.420	0	0
Erythropoietin activates STAT5	R-HSA-9027283	3.803211e-01	0.420	0	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	3.803211e-01	0.420	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.881401e-01	0.726	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.679213e-01	0.572	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.679213e-01	0.572	0	0
Interleukin receptor SHC signaling	R-HSA-912526	2.015544e-01	0.696	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	2.151838e-01	0.667	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.874743e-01	0.541	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.874743e-01	0.541	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	4.124201e-01	0.385	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	4.124201e-01	0.385	0	0
Disinhibition of SNARE formation	R-HSA-114516	4.124201e-01	0.385	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	3.069672e-01	0.513	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.069672e-01	0.513	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.069672e-01	0.513	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.069672e-01	0.513	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.069672e-01	0.513	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.631652e-01	0.787	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	2.570829e-01	0.590	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.570829e-01	0.590	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.428582e-01	0.354	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.428582e-01	0.354	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.428582e-01	0.354	0	0
MET receptor recycling	R-HSA-8875656	4.428582e-01	0.354	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.428582e-01	0.354	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.428582e-01	0.354	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.575089e-01	0.803	0	0
GAB1 signalosome	R-HSA-180292	3.455931e-01	0.461	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	2.172451e-01	0.663	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	3.646482e-01	0.438	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.646482e-01	0.438	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.646482e-01	0.438	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.717213e-01	0.326	0	0
ALK mutants bind TKIs	R-HSA-9700645	4.717213e-01	0.326	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.267594e-01	0.644	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	2.648969e-01	0.577	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.042136e-01	0.690	0	0
EGFR downregulation	R-HSA-182971	3.143381e-01	0.503	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	3.834867e-01	0.416	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.834867e-01	0.416	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.834867e-01	0.416	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.834867e-01	0.416	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.834867e-01	0.416	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.020799e-01	0.396	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.369234e-01	0.625	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.369234e-01	0.625	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.718375e-01	0.430	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.419250e-01	0.616	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	4.384336e-01	0.358	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.384336e-01	0.358	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.270489e-01	0.485	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.270489e-01	0.485	0	0
PPARA activates gene expression	R-HSA-1989781	2.154533e-01	0.667	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	2.483219e-01	0.605	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.070580e-01	0.390	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.559675e-01	0.341	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.559675e-01	0.341	0	0
mRNA Splicing	R-HSA-72172	3.079159e-01	0.512	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.695556e-01	0.328	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.115263e-01	0.386	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.308279e-01	0.366	0	0
Centrosome maturation	R-HSA-380287	4.513381e-01	0.345	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	2.263385e-01	0.645	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.431394e-01	0.465	0	0
G0 and Early G1	R-HSA-1538133	3.287421e-01	0.483	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.162328e-01	0.665	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.162328e-01	0.665	0	0
EPH-Ephrin signaling	R-HSA-2682334	4.579144e-01	0.339	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.162328e-01	0.665	0	0
Cellular response to hypoxia	R-HSA-1234174	3.477812e-01	0.459	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.301587e-01	0.366	0	0
Insulin receptor signalling cascade	R-HSA-74751	1.881106e-01	0.726	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.124201e-01	0.385	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.215342e-01	0.655	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.183348e-01	0.497	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.124201e-01	0.385	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.661503e-01	0.779	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.802515e-01	0.744	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.431394e-01	0.465	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.833321e-01	0.416	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.283696e-01	0.368	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.069672e-01	0.513	0	0
UCH proteinases	R-HSA-5689603	1.640149e-01	0.785	0	0
Homology Directed Repair	R-HSA-5693538	4.038032e-01	0.394	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.561928e-01	0.448	0	0
Hedgehog 'off' state	R-HSA-5610787	2.419250e-01	0.616	0	0
Activation of SMO	R-HSA-5635838	2.874743e-01	0.541	0	0
IRS-mediated signalling	R-HSA-112399	2.659277e-01	0.575	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	4.204029e-01	0.376	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	4.384336e-01	0.358	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.731290e-01	0.564	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.464708e-01	0.460	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.069672e-01	0.513	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	4.428582e-01	0.354	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	3.064515e-01	0.514	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.561533e-01	0.341	0	0
Oncogenic MAPK signaling	R-HSA-6802957	3.741281e-01	0.427	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.881401e-01	0.726	0	0
Fanconi Anemia Pathway	R-HSA-6783310	3.118606e-01	0.506	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	2.094460e-01	0.679	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.718375e-01	0.430	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.429752e-01	0.614	0	0
GPER1 signaling	R-HSA-9634597	1.805622e-01	0.743	0	0
Frs2-mediated activation	R-HSA-170968	2.288467e-01	0.640	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.204029e-01	0.376	0	0
G alpha (z) signalling events	R-HSA-418597	4.305985e-01	0.366	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.461275e-01	0.461	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.107736e-01	0.508	0	0
Activation of AKT2	R-HSA-165158	3.107736e-01	0.508	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.902277e-01	0.721	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.263539e-01	0.486	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.765297e-01	0.558	0	0
Negative regulation of MET activity	R-HSA-6807004	3.834867e-01	0.416	0	0
PI3K Cascade	R-HSA-109704	3.714240e-01	0.430	0	0
Stabilization of p53	R-HSA-69541	4.422351e-01	0.354	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.543329e-01	0.451	0	0
Hedgehog 'on' state	R-HSA-5632684	4.101642e-01	0.387	0	0
Signaling by Insulin receptor	R-HSA-74752	4.579144e-01	0.339	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.999481e-01	0.523	0	0
Interleukin-2 signaling	R-HSA-9020558	1.712696e-01	0.766	0	0
Mitotic Anaphase	R-HSA-68882	3.767243e-01	0.424	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.825674e-01	0.417	0	0
CRMPs in Sema3A signaling	R-HSA-399956	2.483597e-01	0.605	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.204029e-01	0.376	0	0
Mitotic Prometaphase	R-HSA-68877	2.431314e-01	0.614	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.594995e-01	0.444	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.594995e-01	0.444	0	0
Signaling by Hedgehog	R-HSA-5358351	4.409989e-01	0.356	0	0
G2/M Checkpoints	R-HSA-69481	2.284138e-01	0.641	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.306209e-01	0.637	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.419285e-01	0.616	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.419285e-01	0.616	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	4.101642e-01	0.387	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.695556e-01	0.328	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.717213e-01	0.326	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.394086e-01	0.357	0	0
Interleukin-2 family signaling	R-HSA-451927	4.559675e-01	0.341	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.276463e-01	0.369	0	0
Regulation of endogenous retroelements	R-HSA-9842860	2.564778e-01	0.591	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.752852e-01	0.426	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	1.915671e-01	0.718	0	0
C6 deamination of adenosine	R-HSA-75102	1.915671e-01	0.718	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.915671e-01	0.718	0	0
MET interacts with TNS proteins	R-HSA-8875513	2.334308e-01	0.632	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.731290e-01	0.564	0	0
Signaling by APC mutants	R-HSA-4839744	1.712696e-01	0.766	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.107736e-01	0.508	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.902277e-01	0.721	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.902277e-01	0.721	0	0
PDE3B signalling	R-HSA-165160	3.464708e-01	0.460	0	0
PKB-mediated events	R-HSA-109703	3.464708e-01	0.460	0	0
Synthesis of PS	R-HSA-1483101	3.464708e-01	0.460	0	0
G2/M DNA replication checkpoint	R-HSA-69478	3.803211e-01	0.420	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	1.881401e-01	0.726	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.679213e-01	0.572	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.661503e-01	0.779	0	0
Adrenoceptors	R-HSA-390696	4.428582e-01	0.354	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.712973e-01	0.567	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.649454e-01	0.783	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.455931e-01	0.461	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.855936e-01	0.544	0	0
p75NTR regulates axonogenesis	R-HSA-193697	4.717213e-01	0.326	0	0
Unwinding of DNA	R-HSA-176974	4.717213e-01	0.326	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.717213e-01	0.326	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.000248e-01	0.523	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.718375e-01	0.430	0	0
Regulation of TP53 Degradation	R-HSA-6804757	4.002896e-01	0.398	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.545532e-01	0.342	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.802515e-01	0.744	0	0
Prolonged ERK activation events	R-HSA-169893	2.874743e-01	0.541	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.874743e-01	0.541	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.431394e-01	0.465	0	0
Nuclear RNA decay	R-HSA-9930044	3.431394e-01	0.465	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.695556e-01	0.328	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	2.429752e-01	0.614	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.702233e-01	0.769	0	0
Rap1 signalling	R-HSA-392517	3.646482e-01	0.438	0	0
DNA Repair	R-HSA-73894	2.237641e-01	0.650	0	0
Metabolism of RNA	R-HSA-8953854	2.203522e-01	0.657	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.731290e-01	0.564	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	1.902277e-01	0.721	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.620741e-01	0.790	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.679213e-01	0.572	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.124201e-01	0.385	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.263539e-01	0.486	0	0
Specification of the neural plate border	R-HSA-9834899	3.646482e-01	0.438	0	0
Heme signaling	R-HSA-9707616	3.167293e-01	0.499	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.384336e-01	0.358	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.765297e-01	0.558	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	2.223148e-01	0.653	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.369234e-01	0.625	0	0
Cellular responses to stress	R-HSA-2262752	3.692746e-01	0.433	1	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.094460e-01	0.679	0	0
Platelet calcium homeostasis	R-HSA-418360	2.855936e-01	0.544	0	0
Ca2+ pathway	R-HSA-4086398	2.640070e-01	0.578	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.263581e-01	0.486	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.263581e-01	0.486	0	0
Spry regulation of FGF signaling	R-HSA-1295596	2.679213e-01	0.572	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.143381e-01	0.503	0	0
Developmental Biology	R-HSA-1266738	1.763792e-01	0.754	0	0
Vesicle-mediated transport	R-HSA-5653656	4.038281e-01	0.394	0	0
Post NMDA receptor activation events	R-HSA-438064	4.021858e-01	0.396	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.169985e-01	0.499	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.178474e-01	0.662	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.708095e-01	0.767	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.356451e-01	0.474	0	0
Cellular responses to stimuli	R-HSA-8953897	4.136370e-01	0.383	1	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.799558e-01	0.420	0	0
G2/M Transition	R-HSA-69275	2.993551e-01	0.524	0	0
Signaling by NOTCH	R-HSA-157118	2.272930e-01	0.643	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.464708e-01	0.460	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.679213e-01	0.572	0	0
VLDL clearance	R-HSA-8964046	4.124201e-01	0.385	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.069672e-01	0.513	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	2.570829e-01	0.590	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.428582e-01	0.354	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.455931e-01	0.461	0	0
mRNA Editing	R-HSA-75072	4.717213e-01	0.326	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.717213e-01	0.326	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.167293e-01	0.499	0	0
Signaling by ROBO receptors	R-HSA-376176	2.967776e-01	0.528	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.456923e-01	0.610	0	0
Diseases of programmed cell death	R-HSA-9645723	4.115263e-01	0.386	0	0
Semaphorin interactions	R-HSA-373755	3.270489e-01	0.485	0	0
Activation of BH3-only proteins	R-HSA-114452	2.999481e-01	0.523	0	0
Signaling by VEGF	R-HSA-194138	4.671465e-01	0.331	0	0
MTOR signalling	R-HSA-165159	2.765297e-01	0.558	0	0
S Phase	R-HSA-69242	1.792234e-01	0.747	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.475694e-01	0.459	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.167779e-01	0.664	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.533585e-01	0.596	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.377986e-01	0.624	0	0
Cardiogenesis	R-HSA-9733709	3.431394e-01	0.465	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.729050e-01	0.564	0	0
Ovarian tumor domain proteases	R-HSA-5689896	2.084301e-01	0.681	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.261186e-01	0.370	0	0
FLT3 signaling in disease	R-HSA-9682385	4.002896e-01	0.398	0	0
Signaling by Hippo	R-HSA-2028269	3.263539e-01	0.486	0	0
The NLRP1 inflammasome	R-HSA-844455	2.334308e-01	0.632	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.288467e-01	0.640	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.874743e-01	0.541	0	0
Differentiation of T cells	R-HSA-9945266	2.874743e-01	0.541	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.124201e-01	0.385	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	4.124201e-01	0.385	0	0
Regulation of PTEN localization	R-HSA-8948747	4.124201e-01	0.385	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	2.290000e-01	0.640	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.428582e-01	0.354	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.717213e-01	0.326	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.422351e-01	0.354	0	0
Signaling by ERBB4	R-HSA-1236394	4.411053e-01	0.355	0	0
Signaling by PTK6	R-HSA-8848021	3.270489e-01	0.485	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.270489e-01	0.485	0	0
Ion homeostasis	R-HSA-5578775	4.422767e-01	0.354	0	0
Biotin transport and metabolism	R-HSA-196780	2.679213e-01	0.572	0	0
Nephrin family interactions	R-HSA-373753	3.834867e-01	0.416	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.118606e-01	0.506	0	0
Recycling pathway of L1	R-HSA-437239	1.717780e-01	0.765	0	0
Tie2 Signaling	R-HSA-210993	3.455931e-01	0.461	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.646482e-01	0.438	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.749701e-01	0.757	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.084301e-01	0.681	0	0
Signaling by PDGFR in disease	R-HSA-9671555	4.204029e-01	0.376	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.107736e-01	0.508	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.464708e-01	0.460	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.464708e-01	0.460	0	0
p38MAPK events	R-HSA-171007	2.679213e-01	0.572	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.630131e-01	0.334	0	0
MHC class II antigen presentation	R-HSA-2132295	4.434971e-01	0.353	0	0
Signaling by NOTCH2	R-HSA-1980145	3.718375e-01	0.430	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.758421e-01	0.755	1	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.677494e-01	0.775	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	4.717213e-01	0.326	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.758421e-01	0.755	1	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.927023e-01	0.715	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.927023e-01	0.715	1	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.422767e-01	0.354	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.059939e-01	0.686	1	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.559867e-01	0.592	0	0
Signaling by Interleukins	R-HSA-449147	3.449311e-01	0.462	1	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.059939e-01	0.686	1	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.755124e-01	0.756	1	0
Cytokine Signaling in Immune system	R-HSA-1280215	4.229490e-01	0.374	1	0
Host Interactions of HIV factors	R-HSA-162909	4.514001e-01	0.345	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.464708e-01	0.460	0	0
Neurofascin interactions	R-HSA-447043	3.803211e-01	0.420	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.204029e-01	0.376	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.100957e-01	0.678	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.483597e-01	0.605	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.124201e-01	0.385	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.726703e-01	0.564	1	0
Signaling by TGFB family members	R-HSA-9006936	2.430694e-01	0.614	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.520416e-01	0.453	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.679213e-01	0.572	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.428582e-01	0.354	0	0
Apoptotic execution phase	R-HSA-75153	1.631652e-01	0.787	0	0
Toll-like Receptor Cascades	R-HSA-168898	4.403269e-01	0.356	1	0
XBP1(S) activates chaperone genes	R-HSA-381038	3.928358e-01	0.406	0	0
ISG15 antiviral mechanism	R-HSA-1169408	2.818738e-01	0.550	0	0
Death Receptor Signaling	R-HSA-73887	3.105576e-01	0.508	0	0
IRE1alpha activates chaperones	R-HSA-381070	4.486944e-01	0.348	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	4.002896e-01	0.398	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.721387e-01	0.326	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.735457e-01	0.325	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	4.735457e-01	0.325	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.735457e-01	0.325	0	0
Deadenylation of mRNA	R-HSA-429947	4.735457e-01	0.325	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	4.735457e-01	0.325	0	0
Influenza Infection	R-HSA-168255	4.827810e-01	0.316	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.829888e-01	0.316	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.829888e-01	0.316	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	4.829888e-01	0.316	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	4.829888e-01	0.316	0	0
Apoptosis	R-HSA-109581	4.874635e-01	0.312	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.881854e-01	0.311	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.881854e-01	0.311	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.881854e-01	0.311	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.881854e-01	0.311	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.881854e-01	0.311	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.881854e-01	0.311	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.882004e-01	0.311	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	4.905974e-01	0.309	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.905974e-01	0.309	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.905974e-01	0.309	0	0
Acyl chain remodelling of PS	R-HSA-1482801	4.905974e-01	0.309	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.905974e-01	0.309	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	4.905974e-01	0.309	0	0
Adherens junctions interactions	R-HSA-418990	4.986715e-01	0.302	0	0
MAPK3 (ERK1) activation	R-HSA-110056	4.990908e-01	0.302	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.990908e-01	0.302	0	0
Regulation of CDH11 function	R-HSA-9762292	4.990908e-01	0.302	0	0
PI3K/AKT activation	R-HSA-198203	4.990908e-01	0.302	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.990908e-01	0.302	0	0
Formation of intermediate mesoderm	R-HSA-9761174	4.990908e-01	0.302	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.990908e-01	0.302	0	0
Arachidonate production from DAG	R-HSA-426048	4.990908e-01	0.302	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.990908e-01	0.302	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.990908e-01	0.302	0	0
Sperm Motility And Taxes	R-HSA-1300642	4.990908e-01	0.302	0	0
Josephin domain DUBs	R-HSA-5689877	4.990908e-01	0.302	0	0
Signaling by Leptin	R-HSA-2586552	4.990908e-01	0.302	0	0
Pexophagy	R-HSA-9664873	4.990908e-01	0.302	0	0
Separation of Sister Chromatids	R-HSA-2467813	5.012657e-01	0.300	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.016397e-01	0.300	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.016397e-01	0.300	0	0
PKR-mediated signaling	R-HSA-9833482	5.016397e-01	0.300	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.072968e-01	0.295	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.072968e-01	0.295	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.072968e-01	0.295	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.072968e-01	0.295	0	0
MET activates PTK2 signaling	R-HSA-8874081	5.072968e-01	0.295	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.072968e-01	0.295	0	0
Signaling by SCF-KIT	R-HSA-1433557	5.093534e-01	0.293	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.105571e-01	0.292	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	5.114915e-01	0.291	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.114915e-01	0.291	0	0
EPHB-mediated forward signaling	R-HSA-3928662	5.222681e-01	0.282	0	0
Netrin-1 signaling	R-HSA-373752	5.222681e-01	0.282	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	5.236348e-01	0.281	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.236348e-01	0.281	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.236348e-01	0.281	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	5.236348e-01	0.281	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.250439e-01	0.280	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.250439e-01	0.280	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.250439e-01	0.280	0	0
Dissolution of Fibrin Clot	R-HSA-75205	5.250439e-01	0.280	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.250439e-01	0.280	0	0
Synthesis of PI	R-HSA-1483226	5.250439e-01	0.280	0	0
Chylomicron assembly	R-HSA-8963888	5.250439e-01	0.280	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.250439e-01	0.280	0	0
Gastrulation	R-HSA-9758941	5.286920e-01	0.277	0	0
Circadian clock	R-HSA-9909396	5.289433e-01	0.277	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.349946e-01	0.272	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.349946e-01	0.272	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.349946e-01	0.272	0	0
Glycolysis	R-HSA-70171	5.387198e-01	0.269	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.396040e-01	0.268	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.405477e-01	0.267	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.432481e-01	0.265	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	5.475265e-01	0.262	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.496538e-01	0.260	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.496538e-01	0.260	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.496538e-01	0.260	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.496538e-01	0.260	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.496538e-01	0.260	0	0
ERKs are inactivated	R-HSA-202670	5.496538e-01	0.260	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.496538e-01	0.260	0	0
Anchoring fibril formation	R-HSA-2214320	5.496538e-01	0.260	0	0
DS-GAG biosynthesis	R-HSA-2022923	5.496538e-01	0.260	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.551987e-01	0.256	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.551987e-01	0.256	0	0
Regulation of gene expression in beta cells	R-HSA-210745	5.551987e-01	0.256	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.559860e-01	0.255	0	0
PI Metabolism	R-HSA-1483255	5.559860e-01	0.255	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.598582e-01	0.252	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.644052e-01	0.248	0	0
Ub-specific processing proteases	R-HSA-5689880	5.684855e-01	0.245	0	0
DAP12 signaling	R-HSA-2424491	5.704149e-01	0.244	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.704149e-01	0.244	0	0
Interferon Signaling	R-HSA-913531	5.713322e-01	0.243	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.719845e-01	0.243	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.729473e-01	0.242	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.729899e-01	0.242	0	0
Pervasive developmental disorders	R-HSA-9005895	5.729899e-01	0.242	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.729899e-01	0.242	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.729899e-01	0.242	0	0
OAS antiviral response	R-HSA-8983711	5.729899e-01	0.242	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.747796e-01	0.240	0	0
Chaperonin-mediated protein folding	R-HSA-390466	5.779821e-01	0.238	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.813071e-01	0.236	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	5.813071e-01	0.236	0	0
RSV-host interactions	R-HSA-9833110	5.813071e-01	0.236	0	0
Gap junction trafficking and regulation	R-HSA-157858	5.839013e-01	0.234	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.850131e-01	0.233	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.852499e-01	0.233	0	0
Downstream signal transduction	R-HSA-186763	5.852499e-01	0.233	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.922768e-01	0.227	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.951022e-01	0.225	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.951181e-01	0.225	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.951181e-01	0.225	0	0
Adenylate cyclase activating pathway	R-HSA-170660	5.951181e-01	0.225	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	5.951181e-01	0.225	0	0
Chylomicron remodeling	R-HSA-8963901	5.951181e-01	0.225	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.951181e-01	0.225	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.951181e-01	0.225	0	0
Maturation of nucleoprotein	R-HSA-9683610	5.951181e-01	0.225	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.951181e-01	0.225	0	0
Interleukin-6 signaling	R-HSA-1059683	5.951181e-01	0.225	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.951181e-01	0.225	0	0
Regulation of RAS by GAPs	R-HSA-5658442	5.956046e-01	0.225	0	0
DNA strand elongation	R-HSA-69190	5.997024e-01	0.222	0	0
Regulation of mitotic cell cycle	R-HSA-453276	6.050441e-01	0.218	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.050441e-01	0.218	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.050441e-01	0.218	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.137365e-01	0.212	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.137721e-01	0.212	0	0
Activation of ATR in response to replication stress	R-HSA-176187	6.137721e-01	0.212	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	6.137721e-01	0.212	0	0
Integrin signaling	R-HSA-354192	6.137721e-01	0.212	0	0
Recycling of bile acids and salts	R-HSA-159418	6.137721e-01	0.212	0	0
Cell-Cell communication	R-HSA-1500931	6.143356e-01	0.212	0	0
G1/S Transition	R-HSA-69206	6.147538e-01	0.211	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	6.148360e-01	0.211	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.161009e-01	0.210	0	0
Retrograde neurotrophin signalling	R-HSA-177504	6.161009e-01	0.210	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.161009e-01	0.210	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.183590e-01	0.209	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.183590e-01	0.209	0	0
Cell junction organization	R-HSA-446728	6.191744e-01	0.208	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.274600e-01	0.202	0	0
Striated Muscle Contraction	R-HSA-390522	6.274600e-01	0.202	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	6.274600e-01	0.202	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	6.274600e-01	0.202	0	0
Neddylation	R-HSA-8951664	6.288109e-01	0.201	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.294054e-01	0.201	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.294054e-01	0.201	0	0
Protein folding	R-HSA-391251	6.309338e-01	0.200	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.359975e-01	0.197	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.359975e-01	0.197	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	6.359975e-01	0.197	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	6.359975e-01	0.197	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.359975e-01	0.197	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.359975e-01	0.197	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.359975e-01	0.197	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.359975e-01	0.197	0	0
Formation of the anterior neural plate	R-HSA-9823739	6.359975e-01	0.197	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.359975e-01	0.197	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.359975e-01	0.197	0	0
Processive synthesis on the lagging strand	R-HSA-69183	6.359975e-01	0.197	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.359975e-01	0.197	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.359975e-01	0.197	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.407678e-01	0.193	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.407678e-01	0.193	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.407678e-01	0.193	0	0
RAF activation	R-HSA-5673000	6.407678e-01	0.193	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.407678e-01	0.193	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.432904e-01	0.192	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.476575e-01	0.189	0	0
Programmed Cell Death	R-HSA-5357801	6.500736e-01	0.187	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.506741e-01	0.187	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.508282e-01	0.187	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.524621e-01	0.185	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.525422e-01	0.185	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.536981e-01	0.185	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.536981e-01	0.185	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.536981e-01	0.185	0	0
Phosphorylation of the APC/C	R-HSA-176412	6.548640e-01	0.184	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.548640e-01	0.184	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.548640e-01	0.184	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.548640e-01	0.184	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.548640e-01	0.184	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.548640e-01	0.184	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	6.548640e-01	0.184	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	6.548640e-01	0.184	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	6.599816e-01	0.180	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.612029e-01	0.180	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.612029e-01	0.180	0	0
Calmodulin induced events	R-HSA-111933	6.662543e-01	0.176	0	0
CaM pathway	R-HSA-111997	6.662543e-01	0.176	0	0
G1/S-Specific Transcription	R-HSA-69205	6.662543e-01	0.176	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	6.668259e-01	0.176	0	0
Potential therapeutics for SARS	R-HSA-9679191	6.691066e-01	0.175	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	6.703279e-01	0.174	0	0
RNA Polymerase I Transcription	R-HSA-73864	6.703279e-01	0.174	0	0
COPI-mediated anterograde transport	R-HSA-6807878	6.718301e-01	0.173	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.727537e-01	0.172	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.727537e-01	0.172	0	0
Fibronectin matrix formation	R-HSA-1566977	6.727537e-01	0.172	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.727537e-01	0.172	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	6.727537e-01	0.172	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.727537e-01	0.172	0	0
tRNA processing	R-HSA-72306	6.737766e-01	0.171	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.745598e-01	0.171	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.784405e-01	0.168	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.784405e-01	0.168	0	0
Collagen chain trimerization	R-HSA-8948216	6.784405e-01	0.168	0	0
Sensory processing of sound	R-HSA-9659379	6.790203e-01	0.168	0	0
Telomere Maintenance	R-HSA-157579	6.796399e-01	0.168	0	0
Cell-cell junction organization	R-HSA-421270	6.821668e-01	0.166	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	6.897172e-01	0.161	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	6.897172e-01	0.161	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.897172e-01	0.161	0	0
Glycogen storage diseases	R-HSA-3229121	6.897172e-01	0.161	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.897172e-01	0.161	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.897172e-01	0.161	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.897172e-01	0.161	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.897172e-01	0.161	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.902612e-01	0.161	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.909773e-01	0.161	0	0
Regulation of beta-cell development	R-HSA-186712	6.909773e-01	0.161	0	0
Mitochondrial biogenesis	R-HSA-1592230	6.956630e-01	0.158	0	0
Glucose metabolism	R-HSA-70326	6.956630e-01	0.158	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.017215e-01	0.154	0	0
HCMV Early Events	R-HSA-9609690	7.058008e-01	0.151	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	7.058023e-01	0.151	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	7.058023e-01	0.151	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	7.058023e-01	0.151	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.058023e-01	0.151	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.058023e-01	0.151	0	0
PKA activation in glucagon signalling	R-HSA-164378	7.058023e-01	0.151	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	7.058023e-01	0.151	0	0
PKA activation	R-HSA-163615	7.058023e-01	0.151	0	0
Mismatch Repair	R-HSA-5358508	7.058023e-01	0.151	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.097072e-01	0.149	0	0
Endogenous sterols	R-HSA-211976	7.097072e-01	0.149	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.100696e-01	0.149	0	0
Cytoprotection by HMOX1	R-HSA-9707564	7.121761e-01	0.147	0	0
Attenuation phase	R-HSA-3371568	7.128271e-01	0.147	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.128271e-01	0.147	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	7.128271e-01	0.147	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.187395e-01	0.143	0	0
Signaling by PDGF	R-HSA-186797	7.187395e-01	0.143	0	0
Regulation of signaling by CBL	R-HSA-912631	7.210545e-01	0.142	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	7.210545e-01	0.142	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.210545e-01	0.142	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.210545e-01	0.142	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.210545e-01	0.142	0	0
Germ layer formation at gastrulation	R-HSA-9754189	7.210545e-01	0.142	0	0
Diseases of hemostasis	R-HSA-9671793	7.210545e-01	0.142	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.210545e-01	0.142	0	0
STING mediated induction of host immune responses	R-HSA-1834941	7.210545e-01	0.142	0	0
HDL remodeling	R-HSA-8964058	7.210545e-01	0.142	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.210545e-01	0.142	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	7.223070e-01	0.141	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.223503e-01	0.141	0	0
Chromosome Maintenance	R-HSA-73886	7.223503e-01	0.141	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.275520e-01	0.138	0	0
Protein-protein interactions at synapses	R-HSA-6794362	7.277862e-01	0.138	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	7.307783e-01	0.136	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.339983e-01	0.134	0	0
Intra-Golgi traffic	R-HSA-6811438	7.339983e-01	0.134	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.339983e-01	0.134	0	0
Heme biosynthesis	R-HSA-189451	7.339983e-01	0.134	0	0
Macroautophagy	R-HSA-1632852	7.341882e-01	0.134	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.355168e-01	0.133	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.355168e-01	0.133	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.355168e-01	0.133	0	0
Glycogen synthesis	R-HSA-3322077	7.355168e-01	0.133	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.355168e-01	0.133	0	0
Co-inhibition by CTLA4	R-HSA-389513	7.355168e-01	0.133	0	0
Formation of definitive endoderm	R-HSA-9823730	7.355168e-01	0.133	0	0
Synthesis of Ketone Bodies	R-HSA-77111	7.355168e-01	0.133	0	0
Signaling by NODAL	R-HSA-1181150	7.355168e-01	0.133	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.357069e-01	0.133	0	0
Activation of GABAB receptors	R-HSA-991365	7.440768e-01	0.128	0	0
GABA B receptor activation	R-HSA-977444	7.440768e-01	0.128	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.440768e-01	0.128	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.440768e-01	0.128	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	7.440768e-01	0.128	0	0
Ca-dependent events	R-HSA-111996	7.440768e-01	0.128	0	0
Nucleotide Excision Repair	R-HSA-5696398	7.442500e-01	0.128	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.457120e-01	0.127	0	0
G-protein activation	R-HSA-202040	7.492301e-01	0.125	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.492301e-01	0.125	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.492301e-01	0.125	1	1
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.492301e-01	0.125	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.492301e-01	0.125	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.492301e-01	0.125	0	0
Basigin interactions	R-HSA-210991	7.492301e-01	0.125	0	0
Lagging Strand Synthesis	R-HSA-69186	7.492301e-01	0.125	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.492301e-01	0.125	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.492301e-01	0.125	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.538261e-01	0.123	0	0
SARS-CoV-2 Infection	R-HSA-9694516	7.560448e-01	0.121	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	7.606451e-01	0.119	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.622332e-01	0.118	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.622332e-01	0.118	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.622332e-01	0.118	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.622332e-01	0.118	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.622332e-01	0.118	0	0
Gap junction trafficking	R-HSA-190828	7.632535e-01	0.117	0	0
DAP12 interactions	R-HSA-2172127	7.632535e-01	0.117	0	0
Stimuli-sensing channels	R-HSA-2672351	7.635149e-01	0.117	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	7.683909e-01	0.114	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.700632e-01	0.113	0	0
Base Excision Repair	R-HSA-73884	7.708011e-01	0.113	0	0
SARS-CoV Infections	R-HSA-9679506	7.721858e-01	0.112	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	7.723659e-01	0.112	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.723659e-01	0.112	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.723659e-01	0.112	0	0
DAG and IP3 signaling	R-HSA-1489509	7.723659e-01	0.112	0	0
mTORC1-mediated signalling	R-HSA-166208	7.745628e-01	0.111	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.745628e-01	0.111	0	0
Notch-HLH transcription pathway	R-HSA-350054	7.745628e-01	0.111	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.745628e-01	0.111	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.745628e-01	0.111	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.745628e-01	0.111	0	0
Signaling by KIT in disease	R-HSA-9669938	7.745628e-01	0.111	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.745628e-01	0.111	0	0
LDL clearance	R-HSA-8964038	7.745628e-01	0.111	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.811707e-01	0.107	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.811707e-01	0.107	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.811707e-01	0.107	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.811707e-01	0.107	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	7.811707e-01	0.107	0	0
Signaling by RAS mutants	R-HSA-6802949	7.811707e-01	0.107	0	0
Diseases of DNA repair	R-HSA-9675135	7.811707e-01	0.107	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	7.811707e-01	0.107	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.832686e-01	0.106	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.855642e-01	0.105	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.862538e-01	0.104	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.862538e-01	0.104	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	7.862538e-01	0.104	0	0
Carnitine shuttle	R-HSA-200425	7.862538e-01	0.104	0	0
Ketone body metabolism	R-HSA-74182	7.862538e-01	0.104	0	0
Formation of the ureteric bud	R-HSA-9830674	7.862538e-01	0.104	0	0
Syndecan interactions	R-HSA-3000170	7.862538e-01	0.104	0	0
Growth hormone receptor signaling	R-HSA-982772	7.862538e-01	0.104	0	0
FCERI mediated MAPK activation	R-HSA-2871796	7.874681e-01	0.104	1	1
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.896753e-01	0.103	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.902178e-01	0.102	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.931679e-01	0.101	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.973391e-01	0.098	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.973391e-01	0.098	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.973391e-01	0.098	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.973391e-01	0.098	0	0
Plasma lipoprotein assembly	R-HSA-8963898	7.973391e-01	0.098	0	0
Interleukin-6 family signaling	R-HSA-6783589	7.973391e-01	0.098	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.973478e-01	0.098	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	7.973478e-01	0.098	0	0
Co-stimulation by CD28	R-HSA-389356	7.978872e-01	0.098	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	7.978872e-01	0.098	0	0
Adaptive Immune System	R-HSA-1280218	8.021933e-01	0.096	0	0
Switching of origins to a post-replicative state	R-HSA-69052	8.040960e-01	0.095	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.040960e-01	0.095	0	0
Degradation of CDH1	R-HSA-9766229	8.058137e-01	0.094	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.078502e-01	0.093	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.078502e-01	0.093	0	0
G protein gated Potassium channels	R-HSA-1296059	8.078502e-01	0.093	0	0
Laminin interactions	R-HSA-3000157	8.078502e-01	0.093	0	0
Long-term potentiation	R-HSA-9620244	8.078502e-01	0.093	0	0
Sema4D in semaphorin signaling	R-HSA-400685	8.078502e-01	0.093	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	8.078502e-01	0.093	0	0
Fertilization	R-HSA-1187000	8.078502e-01	0.093	0	0
Interleukin-7 signaling	R-HSA-1266695	8.078502e-01	0.093	0	0
Autophagy	R-HSA-9612973	8.164816e-01	0.088	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.170259e-01	0.088	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.170259e-01	0.088	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.178167e-01	0.087	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.178167e-01	0.087	0	0
Metalloprotease DUBs	R-HSA-5689901	8.178167e-01	0.087	0	0
Attachment of bacteria to epithelial cells	R-HSA-9638630	8.178167e-01	0.087	0	0
TRP channels	R-HSA-3295583	8.178167e-01	0.087	0	0
Suppression of phagosomal maturation	R-HSA-9637687	8.178167e-01	0.087	0	0
HSF1-dependent transactivation	R-HSA-3371571	8.208409e-01	0.086	0	0
Meiotic recombination	R-HSA-912446	8.208409e-01	0.086	0	0
HCMV Late Events	R-HSA-9610379	8.208906e-01	0.086	0	0
Integration of energy metabolism	R-HSA-163685	8.219591e-01	0.085	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.272668e-01	0.082	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.272668e-01	0.082	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.272668e-01	0.082	0	0
Cristae formation	R-HSA-8949613	8.272668e-01	0.082	0	0
Insulin processing	R-HSA-264876	8.272668e-01	0.082	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	8.279565e-01	0.082	0	0
Orc1 removal from chromatin	R-HSA-68949	8.279565e-01	0.082	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.279565e-01	0.082	0	0
Translation of Structural Proteins	R-HSA-9694635	8.292237e-01	0.081	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.348165e-01	0.078	0	0
Smooth Muscle Contraction	R-HSA-445355	8.348165e-01	0.078	0	0
PCP/CE pathway	R-HSA-4086400	8.350568e-01	0.078	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.362273e-01	0.078	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.362273e-01	0.078	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.362273e-01	0.078	0	0
Pyrimidine salvage	R-HSA-73614	8.362273e-01	0.078	0	0
Pyroptosis	R-HSA-5620971	8.362273e-01	0.078	0	0
Inflammasomes	R-HSA-622312	8.362273e-01	0.078	0	0
Cellular response to chemical stress	R-HSA-9711123	8.372856e-01	0.077	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.414285e-01	0.075	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.414285e-01	0.075	0	0
DNA methylation	R-HSA-5334118	8.447235e-01	0.073	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	8.447235e-01	0.073	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.447235e-01	0.073	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.447235e-01	0.073	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.447235e-01	0.073	0	0
Interleukin-1 signaling	R-HSA-9020702	8.455541e-01	0.073	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.462096e-01	0.073	0	0
Signaling by NOTCH3	R-HSA-9012852	8.477996e-01	0.072	0	0
HCMV Infection	R-HSA-9609646	8.487224e-01	0.071	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.523933e-01	0.069	0	0
Activation of the pre-replicative complex	R-HSA-68962	8.527794e-01	0.069	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.527794e-01	0.069	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.527794e-01	0.069	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.527794e-01	0.069	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.539370e-01	0.069	0	0
TNF signaling	R-HSA-75893	8.539370e-01	0.069	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.595496e-01	0.066	0	0
Regulation of CDH1 Function	R-HSA-9764561	8.598478e-01	0.066	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.604178e-01	0.065	0	0
Trafficking of AMPA receptors	R-HSA-399719	8.604178e-01	0.065	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.604178e-01	0.065	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.604178e-01	0.065	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.604178e-01	0.065	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.638070e-01	0.064	0	0
Cilium Assembly	R-HSA-5617833	8.654307e-01	0.063	0	0
Dual incision in TC-NER	R-HSA-6782135	8.655390e-01	0.063	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.665622e-01	0.062	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.674141e-01	0.062	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	8.676603e-01	0.062	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.676603e-01	0.062	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.676603e-01	0.062	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.676603e-01	0.062	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	8.709819e-01	0.060	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.710174e-01	0.060	0	0
Extension of Telomeres	R-HSA-180786	8.710174e-01	0.060	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.710174e-01	0.060	0	0
Meiosis	R-HSA-1500620	8.712647e-01	0.060	0	0
Platelet homeostasis	R-HSA-418346	8.724486e-01	0.059	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.724486e-01	0.059	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.745275e-01	0.058	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.745275e-01	0.058	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.745275e-01	0.058	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.745275e-01	0.058	0	0
GABA receptor activation	R-HSA-977443	8.762899e-01	0.057	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.762899e-01	0.057	0	0
Synthesis of DNA	R-HSA-69239	8.765153e-01	0.057	0	0
G alpha (s) signalling events	R-HSA-418555	8.775077e-01	0.057	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.810387e-01	0.055	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.810387e-01	0.055	0	0
Vpu mediated degradation of CD4	R-HSA-180534	8.810387e-01	0.055	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.810387e-01	0.055	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	8.810387e-01	0.055	0	0
Aquaporin-mediated transport	R-HSA-445717	8.813629e-01	0.055	0	0
Collagen degradation	R-HSA-1442490	8.813629e-01	0.055	0	0
Formation of paraxial mesoderm	R-HSA-9793380	8.813629e-01	0.055	0	0
PLC beta mediated events	R-HSA-112043	8.813629e-01	0.055	0	0
Nucleotide salvage	R-HSA-8956321	8.813629e-01	0.055	0	0
Developmental Cell Lineages	R-HSA-9734767	8.857759e-01	0.053	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.862431e-01	0.052	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.862431e-01	0.052	0	0
Signal amplification	R-HSA-392518	8.872124e-01	0.052	0	0
Gap junction assembly	R-HSA-190861	8.872124e-01	0.052	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.872124e-01	0.052	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.872124e-01	0.052	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.872124e-01	0.052	0	0
Mitophagy	R-HSA-5205647	8.872124e-01	0.052	0	0
Selective autophagy	R-HSA-9663891	8.886395e-01	0.051	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.930661e-01	0.049	0	0
Acyl chain remodelling of PE	R-HSA-1482839	8.930661e-01	0.049	0	0
Regulation of Apoptosis	R-HSA-169911	8.930661e-01	0.049	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.930661e-01	0.049	0	0
PERK regulates gene expression	R-HSA-381042	8.930661e-01	0.049	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.930661e-01	0.049	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.968077e-01	0.047	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.986163e-01	0.046	0	0
HSF1 activation	R-HSA-3371511	8.986163e-01	0.046	0	0
RNA Polymerase III Transcription	R-HSA-74158	8.986163e-01	0.046	0	0
PRC2 methylates histones and DNA	R-HSA-212300	8.986163e-01	0.046	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.986163e-01	0.046	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.986163e-01	0.046	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.986163e-01	0.046	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.997888e-01	0.046	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	9.038787e-01	0.044	0	0
Cleavage of the damaged purine	R-HSA-110331	9.038787e-01	0.044	0	0
Degradation of DVL	R-HSA-4641258	9.038787e-01	0.044	0	0
Degradation of AXIN	R-HSA-4641257	9.038787e-01	0.044	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.038787e-01	0.044	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.038787e-01	0.044	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.051856e-01	0.043	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.073915e-01	0.042	0	0
G-protein mediated events	R-HSA-112040	9.079674e-01	0.042	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.079674e-01	0.042	0	0
Interferon gamma signaling	R-HSA-877300	9.082033e-01	0.042	0	0
Depurination	R-HSA-73927	9.088683e-01	0.041	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.088683e-01	0.041	0	0
Biofilm formation	R-HSA-9931953	9.088683e-01	0.041	0	0
Purine salvage	R-HSA-74217	9.088683e-01	0.041	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.088683e-01	0.041	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.088683e-01	0.041	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.107803e-01	0.041	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.107803e-01	0.041	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.110360e-01	0.040	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.113631e-01	0.040	0	0
Regulated Necrosis	R-HSA-5218859	9.118185e-01	0.040	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.135992e-01	0.039	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.135992e-01	0.039	0	0
RAS processing	R-HSA-9648002	9.135992e-01	0.039	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.135992e-01	0.039	0	0
Collagen formation	R-HSA-1474290	9.140561e-01	0.039	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.172221e-01	0.038	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.180847e-01	0.037	0	0
Glycogen metabolism	R-HSA-8982491	9.180847e-01	0.037	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.180847e-01	0.037	0	0
Aggrephagy	R-HSA-9646399	9.180847e-01	0.037	0	0
Generation of second messenger molecules	R-HSA-202433	9.180847e-01	0.037	0	0
rRNA processing	R-HSA-72312	9.186666e-01	0.037	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.220502e-01	0.035	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.223377e-01	0.035	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.223377e-01	0.035	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.223377e-01	0.035	0	0
Maturation of spike protein	R-HSA-9694548	9.223377e-01	0.035	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.223377e-01	0.035	0	0
ECM proteoglycans	R-HSA-3000178	9.224840e-01	0.035	0	0
Metabolism of porphyrins	R-HSA-189445	9.224840e-01	0.035	0	0
Muscle contraction	R-HSA-397014	9.255107e-01	0.034	0	0
MAP2K and MAPK activation	R-HSA-5674135	9.263700e-01	0.033	0	0
Signaling by RAF1 mutants	R-HSA-9656223	9.263700e-01	0.033	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.263700e-01	0.033	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.263700e-01	0.033	0	0
Translation of Structural Proteins	R-HSA-9683701	9.263700e-01	0.033	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.263700e-01	0.033	0	0
SLC transporter disorders	R-HSA-5619102	9.275170e-01	0.033	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.288499e-01	0.032	0	0
Regulation of insulin secretion	R-HSA-422356	9.288499e-01	0.032	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.301933e-01	0.031	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.315126e-01	0.031	0	0
Hemostasis	R-HSA-109582	9.316086e-01	0.031	0	0
Signaling by NOTCH4	R-HSA-9013694	9.319257e-01	0.031	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.319257e-01	0.031	0	0
Defective pyroptosis	R-HSA-9710421	9.338182e-01	0.030	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.338182e-01	0.030	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.338182e-01	0.030	0	0
Iron uptake and transport	R-HSA-917937	9.348235e-01	0.029	0	0
G alpha (q) signalling events	R-HSA-416476	9.349019e-01	0.029	0	0
Amine ligand-binding receptors	R-HSA-375280	9.372551e-01	0.028	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.372551e-01	0.028	0	0
Surfactant metabolism	R-HSA-5683826	9.372551e-01	0.028	0	0
Proteasome assembly	R-HSA-9907900	9.372551e-01	0.028	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.372551e-01	0.028	0	0
Interleukin-12 signaling	R-HSA-9020591	9.376041e-01	0.028	0	0
Nucleosome assembly	R-HSA-774815	9.405137e-01	0.027	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.405137e-01	0.027	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.405137e-01	0.027	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.405137e-01	0.027	0	0
Somitogenesis	R-HSA-9824272	9.405137e-01	0.027	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.405137e-01	0.027	0	0
Interleukin-10 signaling	R-HSA-6783783	9.428313e-01	0.026	0	0
Platelet degranulation	R-HSA-114608	9.434674e-01	0.025	0	0
Opioid Signalling	R-HSA-111885	9.435007e-01	0.025	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.436033e-01	0.025	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.436033e-01	0.025	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.448879e-01	0.025	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.465326e-01	0.024	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.465326e-01	0.024	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.471447e-01	0.024	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.471447e-01	0.024	0	0
Intraflagellar transport	R-HSA-5620924	9.493099e-01	0.023	0	0
Reproduction	R-HSA-1474165	9.509617e-01	0.022	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.516567e-01	0.022	0	0
DNA Damage Bypass	R-HSA-73893	9.519431e-01	0.021	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.519431e-01	0.021	0	0
Cardiac conduction	R-HSA-5576891	9.526870e-01	0.021	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.535168e-01	0.021	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.535168e-01	0.021	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.543564e-01	0.020	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.544397e-01	0.020	0	0
DNA Replication Pre-Initiation	R-HSA-69002	9.553098e-01	0.020	0	0
Viral Infection Pathways	R-HSA-9824446	9.555872e-01	0.020	0	0
Complex IV assembly	R-HSA-9864848	9.568067e-01	0.019	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.568067e-01	0.019	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.568067e-01	0.019	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.568067e-01	0.019	0	0
The phototransduction cascade	R-HSA-2514856	9.568067e-01	0.019	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.570380e-01	0.019	0	0
Neurexins and neuroligins	R-HSA-6794361	9.590509e-01	0.018	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.590509e-01	0.018	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.590509e-01	0.018	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.598592e-01	0.018	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.603082e-01	0.018	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.603082e-01	0.018	0	0
Meiotic synapsis	R-HSA-1221632	9.611786e-01	0.017	0	0
Translation initiation complex formation	R-HSA-72649	9.631958e-01	0.016	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.631958e-01	0.016	0	0
Interleukin-12 family signaling	R-HSA-447115	9.632866e-01	0.016	0	0
Ion channel transport	R-HSA-983712	9.645828e-01	0.016	0	0
Peptide chain elongation	R-HSA-156902	9.648932e-01	0.016	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.651084e-01	0.015	0	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.651084e-01	0.015	0	0
ER-Phagosome pathway	R-HSA-1236974	9.664320e-01	0.015	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	9.669217e-01	0.015	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.669217e-01	0.015	0	0
Leishmania phagocytosis	R-HSA-9664417	9.671122e-01	0.015	0	0
Parasite infection	R-HSA-9664407	9.671122e-01	0.015	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.671122e-01	0.015	0	0
Neurotransmitter release cycle	R-HSA-112310	9.679059e-01	0.014	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.687707e-01	0.014	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.687707e-01	0.014	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.693173e-01	0.014	0	0
Peptide hormone metabolism	R-HSA-2980736	9.700037e-01	0.013	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.702708e-01	0.013	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.702708e-01	0.013	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.706689e-01	0.013	0	0
Phospholipid metabolism	R-HSA-1483257	9.713566e-01	0.013	0	0
Peroxisomal protein import	R-HSA-9033241	9.718160e-01	0.012	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.719630e-01	0.012	0	0
Metabolism of polyamines	R-HSA-351202	9.732811e-01	0.012	0	0
tRNA Aminoacylation	R-HSA-379724	9.732811e-01	0.012	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.741291e-01	0.011	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.755230e-01	0.011	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.758950e-01	0.011	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.766095e-01	0.010	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.766095e-01	0.010	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.766095e-01	0.010	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.768798e-01	0.010	0	0
Complex I biogenesis	R-HSA-6799198	9.772354e-01	0.010	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.776393e-01	0.010	1	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.776492e-01	0.010	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.784190e-01	0.009	0	0
Xenobiotics	R-HSA-211981	9.784190e-01	0.009	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.784190e-01	0.009	0	0
Interleukin-1 family signaling	R-HSA-446652	9.797836e-01	0.009	0	0
DNA Replication	R-HSA-69306	9.805379e-01	0.009	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.806051e-01	0.009	0	0
Kidney development	R-HSA-9830369	9.816137e-01	0.008	0	0
Selenocysteine synthesis	R-HSA-2408557	9.822119e-01	0.008	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.825699e-01	0.008	0	0
Viral mRNA Translation	R-HSA-192823	9.837717e-01	0.007	0	0
Cellular response to starvation	R-HSA-9711097	9.839273e-01	0.007	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.839273e-01	0.007	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.843359e-01	0.007	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.843359e-01	0.007	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.843359e-01	0.007	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.851507e-01	0.006	0	0
Retinoid metabolism and transport	R-HSA-975634	9.851507e-01	0.006	0	0
Immune System	R-HSA-168256	9.862112e-01	0.006	1	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.866555e-01	0.006	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.876947e-01	0.005	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.878862e-01	0.005	0	0
TCR signaling	R-HSA-202403	9.887840e-01	0.005	0	0
Ribosome-associated quality control	R-HSA-9948299	9.888661e-01	0.005	0	0
ABC transporter disorders	R-HSA-5619084	9.897842e-01	0.004	0	0
Integrin cell surface interactions	R-HSA-216083	9.897842e-01	0.004	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.897842e-01	0.004	0	0
Cholesterol biosynthesis	R-HSA-191273	9.897842e-01	0.004	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.903159e-01	0.004	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.912977e-01	0.004	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.919049e-01	0.004	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.921801e-01	0.003	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.925872e-01	0.003	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.933759e-01	0.003	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.949018e-01	0.002	0	0
Downstream TCR signaling	R-HSA-202424	9.949018e-01	0.002	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.960983e-01	0.002	0	0
Neuronal System	R-HSA-112316	9.965436e-01	0.002	0	0
Potassium Channels	R-HSA-1296071	9.966769e-01	0.001	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.966769e-01	0.001	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.969436e-01	0.001	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.973173e-01	0.001	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.974515e-01	0.001	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.975477e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.980579e-01	0.001	0	0
Extracellular matrix organization	R-HSA-1474244	9.982606e-01	0.001	0	0
Visual phototransduction	R-HSA-2187338	9.985375e-01	0.001	0	0
GPCR downstream signalling	R-HSA-388396	9.986752e-01	0.001	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.987155e-01	0.001	0	0
Leishmania infection	R-HSA-9658195	9.987155e-01	0.001	0	0
Arachidonate metabolism	R-HSA-2142753	9.988512e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.989055e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.992197e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.992583e-01	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.993584e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.993685e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.994623e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.995422e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.996064e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.996064e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.996920e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.998169e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.998258e-01	0.000	0	0
Neutrophil degranulation	R-HSA-6798695	9.998569e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.998589e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998738e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.998783e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999011e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999431e-01	0.000	0	0
Disease	R-HSA-1643685	9.999714e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999768e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999779e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999808e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999827e-01	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	9.999833e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999846e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999850e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999882e-01	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	9.999931e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999944e-01	0.000	0	0
Translation	R-HSA-72766	9.999973e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999978e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999990e-01	0.000	1	0
Phase II - Conjugation of compounds	R-HSA-156580	9.999991e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999997e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999998e-01	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	9.999998e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.000000e+00	0.000	1	1

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	6.217249e-15	14.206	0	0
Cell Cycle, Mitotic	R-HSA-69278	4.589662e-13	12.338	0	0
Cellular response to heat stress	R-HSA-3371556	4.779399e-12	11.321	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.850418e-10	9.414	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.344963e-09	8.871	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	4.554289e-09	8.342	0	0
M Phase	R-HSA-68886	8.725780e-09	8.059	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.139488e-08	7.943	0	0
Cellular responses to stress	R-HSA-2262752	5.561443e-08	7.255	1	0
Mitotic Prometaphase	R-HSA-68877	1.254324e-07	6.902	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.665294e-07	6.436	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.622573e-07	6.250	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.241043e-07	6.281	0	0
Mitotic Anaphase	R-HSA-68882	5.654447e-07	6.248	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.397456e-07	6.194	0	0
Nuclear import of Rev protein	R-HSA-180746	7.410615e-07	6.130	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.123421e-07	6.090	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.123421e-07	6.090	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.011875e-07	6.045	0	0
Cellular responses to stimuli	R-HSA-8953897	8.702081e-07	6.060	1	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.011875e-07	6.045	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.036703e-06	5.984	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.229166e-06	5.910	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.634904e-06	5.787	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.657013e-06	5.781	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.759420e-06	5.755	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.874378e-06	5.727	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.968819e-06	5.706	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.310210e-06	5.636	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.280244e-06	5.642	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.609239e-06	5.443	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.753633e-06	5.426	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.134089e-06	5.384	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.811426e-06	5.318	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	4.811426e-06	5.318	0	0
Membrane Trafficking	R-HSA-199991	5.947443e-06	5.226	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.373411e-06	5.196	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.745525e-06	5.111	0	0
Signaling by ALK in cancer	R-HSA-9700206	7.745525e-06	5.111	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.533760e-06	5.069	0	0
Separation of Sister Chromatids	R-HSA-2467813	9.570108e-06	5.019	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.036754e-05	4.984	0	0
Activation of BH3-only proteins	R-HSA-114452	1.103689e-05	4.957	0	0
Chromatin organization	R-HSA-4839726	1.074445e-05	4.969	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.366865e-05	4.864	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.889247e-05	4.724	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.982270e-05	4.703	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.026969e-05	4.693	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.064697e-05	4.514	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.064697e-05	4.514	0	0
Mitotic Prophase	R-HSA-68875	2.966534e-05	4.528	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.612636e-05	4.442	0	0
Apoptosis	R-HSA-109581	3.579986e-05	4.446	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.821181e-05	4.418	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.048966e-05	4.393	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.048966e-05	4.393	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.894814e-05	4.410	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	4.569777e-05	4.340	1	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	4.773939e-05	4.321	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.107033e-05	4.214	0	0
Chromatin modifying enzymes	R-HSA-3247509	6.991287e-05	4.155	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.685683e-05	4.114	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.842460e-05	4.106	0	0
HSF1-dependent transactivation	R-HSA-3371571	8.937047e-05	4.049	0	0
Apoptotic execution phase	R-HSA-75153	9.583333e-05	4.018	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.583333e-05	4.018	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.033424e-04	3.986	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.077906e-04	3.967	0	0
MTOR signalling	R-HSA-165159	1.263980e-04	3.898	0	0
G2/M Transition	R-HSA-69275	1.261603e-04	3.899	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.462532e-04	3.835	0	0
snRNP Assembly	R-HSA-191859	1.462532e-04	3.835	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.554078e-04	3.809	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.616843e-04	3.791	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.661283e-04	3.780	0	0
Interferon Signaling	R-HSA-913531	1.835995e-04	3.736	0	0
Kinesins	R-HSA-983189	1.758031e-04	3.755	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.104658e-04	3.677	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.215710e-04	3.654	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.258761e-04	3.646	0	0
PKR-mediated signaling	R-HSA-9833482	2.643208e-04	3.578	0	0
tRNA processing in the nucleus	R-HSA-6784531	2.509699e-04	3.600	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.694289e-04	3.570	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.981235e-04	3.526	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.981235e-04	3.526	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.485016e-04	3.458	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.485016e-04	3.458	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.434112e-04	3.464	0	0
Metabolism of RNA	R-HSA-8953854	3.460994e-04	3.461	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.521777e-04	3.453	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.521777e-04	3.453	0	0
MITF-M-dependent gene expression	R-HSA-9856651	3.698300e-04	3.432	0	0
Programmed Cell Death	R-HSA-5357801	4.264048e-04	3.370	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.751480e-04	3.323	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	4.800609e-04	3.319	0	0
MHC class II antigen presentation	R-HSA-2132295	4.832125e-04	3.316	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.888683e-04	3.311	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	5.283190e-04	3.277	0	0
Signal Transduction	R-HSA-162582	5.368134e-04	3.270	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.865219e-04	3.232	0	0
Gene expression (Transcription)	R-HSA-74160	6.344111e-04	3.198	0	0
Attenuation phase	R-HSA-3371568	6.489725e-04	3.188	0	0
Aggrephagy	R-HSA-9646399	6.489725e-04	3.188	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	6.536657e-04	3.185	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.576306e-04	3.121	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	7.576306e-04	3.121	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	8.527886e-04	3.069	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.527886e-04	3.069	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.527886e-04	3.069	0	0
Signaling by RAS mutants	R-HSA-6802949	8.527886e-04	3.069	0	0
Interleukin-12 signaling	R-HSA-9020591	8.810779e-04	3.055	0	0
G0 and Early G1	R-HSA-1538133	9.402607e-04	3.027	0	0
MAP2K and MAPK activation	R-HSA-5674135	9.608808e-04	3.017	0	0
Signaling by RAF1 mutants	R-HSA-9656223	9.608808e-04	3.017	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	9.712920e-04	3.013	0	0
Recycling pathway of L1	R-HSA-437239	1.020393e-03	2.991	0	0
mTORC1-mediated signalling	R-HSA-166208	9.929091e-04	3.003	0	0
Glycolysis	R-HSA-70171	1.069025e-03	2.971	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.123124e-03	2.950	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.123124e-03	2.950	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.160613e-03	2.935	0	0
Formation of annular gap junctions	R-HSA-196025	1.280647e-03	2.893	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.284887e-03	2.891	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.380628e-03	2.860	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.412271e-03	2.850	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.510358e-03	2.821	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.575752e-03	2.803	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.639393e-03	2.785	0	0
Centrosome maturation	R-HSA-380287	1.808295e-03	2.743	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.820335e-03	2.740	0	0
Interleukin-12 family signaling	R-HSA-447115	1.845303e-03	2.734	0	0
Gap junction degradation	R-HSA-190873	1.976160e-03	2.704	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.983671e-03	2.703	0	0
HDMs demethylate histones	R-HSA-3214842	2.078530e-03	2.682	0	0
Inositol phosphate metabolism	R-HSA-1483249	2.156628e-03	2.666	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.386684e-03	2.622	0	0
HSF1 activation	R-HSA-3371511	2.586979e-03	2.587	0	0
Signaling by Hippo	R-HSA-2028269	2.761244e-03	2.559	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	2.806472e-03	2.552	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.053459e-03	2.515	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.957247e-03	2.529	0	0
Cellular Senescence	R-HSA-2559583	3.145551e-03	2.502	1	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.533306e-03	2.452	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.559167e-03	2.449	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.964395e-03	2.402	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.087118e-03	2.389	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.087118e-03	2.389	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.087118e-03	2.389	0	0
FOXO-mediated transcription	R-HSA-9614085	4.192338e-03	2.378	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.252509e-03	2.371	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	4.615571e-03	2.336	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.615571e-03	2.336	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.829683e-03	2.316	1	0
Vesicle-mediated transport	R-HSA-5653656	4.353044e-03	2.361	0	0
Selective autophagy	R-HSA-9663891	4.442943e-03	2.352	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	5.849894e-03	2.233	0	0
HCMV Early Events	R-HSA-9609690	5.878994e-03	2.231	0	0
Regulation of TP53 Activity	R-HSA-5633007	5.949079e-03	2.226	0	0
Intracellular signaling by second messengers	R-HSA-9006925	5.953574e-03	2.225	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.038029e-03	2.219	0	0
G2/M Checkpoints	R-HSA-69481	6.095641e-03	2.215	0	0
RET signaling	R-HSA-8853659	7.127878e-03	2.147	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.396172e-03	2.131	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.804089e-03	2.167	0	0
Axon guidance	R-HSA-422475	6.591295e-03	2.181	0	0
Macroautophagy	R-HSA-1632852	6.927076e-03	2.159	0	0
Autophagy	R-HSA-9612973	7.666412e-03	2.115	0	0
Host Interactions of HIV factors	R-HSA-162909	7.980995e-03	2.098	0	0
Cell-Cell communication	R-HSA-1500931	7.984551e-03	2.098	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	8.102396e-03	2.091	0	0
Glucose metabolism	R-HSA-70326	8.104971e-03	2.091	0	0
Post NMDA receptor activation events	R-HSA-438064	8.197722e-03	2.086	0	0
HIV Life Cycle	R-HSA-162587	8.254886e-03	2.083	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	8.335634e-03	2.079	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.105101e-03	2.041	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.662740e-03	2.015	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	9.683829e-03	2.014	0	0
UCH proteinases	R-HSA-5689603	9.756705e-03	2.011	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.898484e-03	2.004	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.030606e-02	1.987	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.030606e-02	1.987	0	0
PTEN Regulation	R-HSA-6807070	1.047413e-02	1.980	0	0
Nervous system development	R-HSA-9675108	1.061819e-02	1.974	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.095758e-02	1.960	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.236512e-02	1.908	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.241425e-02	1.906	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.236512e-02	1.908	0	0
Gap junction trafficking	R-HSA-190828	1.089822e-02	1.963	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.133434e-02	1.946	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.221352e-02	1.913	0	0
Signaling by Interleukins	R-HSA-449147	1.112096e-02	1.954	1	0
S Phase	R-HSA-69242	1.264681e-02	1.898	0	0
Signaling by NTRKs	R-HSA-166520	1.264681e-02	1.898	0	0
Cell junction organization	R-HSA-446728	1.310234e-02	1.883	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.315628e-02	1.881	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.315628e-02	1.881	0	0
L1CAM interactions	R-HSA-373760	1.360786e-02	1.866	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.389096e-02	1.857	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.405630e-02	1.852	0	0
Influenza Infection	R-HSA-168255	1.420111e-02	1.848	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.505729e-02	1.822	0	0
HATs acetylate histones	R-HSA-3214847	1.572994e-02	1.803	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.577904e-02	1.802	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.577904e-02	1.802	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.603759e-02	1.795	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.603759e-02	1.795	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.615957e-02	1.792	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.667119e-02	1.778	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.688298e-02	1.773	0	0
G1/S-Specific Transcription	R-HSA-69205	1.814069e-02	1.741	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.906276e-02	1.720	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.906276e-02	1.720	0	0
G1/S Transition	R-HSA-69206	1.669591e-02	1.777	0	0
MAP kinase activation	R-HSA-450294	1.745090e-02	1.758	1	0
Signaling by VEGF	R-HSA-194138	1.669591e-02	1.777	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.814069e-02	1.741	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.943529e-02	1.711	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.946429e-02	1.711	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.946429e-02	1.711	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.946429e-02	1.711	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.946429e-02	1.711	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.946429e-02	1.711	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.021441e-02	1.694	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.046813e-02	1.689	0	0
Gap junction trafficking and regulation	R-HSA-157858	2.061168e-02	1.686	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	2.066610e-02	1.685	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.247447e-02	1.648	0	0
Myogenesis	R-HSA-525793	2.247447e-02	1.648	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.247447e-02	1.648	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.247447e-02	1.648	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.272401e-02	1.644	0	0
MECP2 regulates transcription factors	R-HSA-9022707	2.272401e-02	1.644	0	0
Activation of RAC1	R-HSA-428540	2.292701e-02	1.640	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.292701e-02	1.640	0	0
Regulation of CDH1 Function	R-HSA-9764561	2.367922e-02	1.626	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.372616e-02	1.625	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	2.372616e-02	1.625	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.464772e-02	1.608	0	0
HIV Infection	R-HSA-162906	2.511267e-02	1.600	0	0
mRNA Splicing	R-HSA-72172	2.620392e-02	1.582	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.628477e-02	1.580	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.667736e-02	1.574	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.667736e-02	1.574	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.669705e-02	1.574	0	0
Cilium Assembly	R-HSA-5617833	2.734960e-02	1.563	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.769991e-02	1.558	0	0
Repression of WNT target genes	R-HSA-4641265	2.910603e-02	1.536	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.910603e-02	1.536	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	3.023915e-02	1.519	0	0
Deubiquitination	R-HSA-5688426	3.049508e-02	1.516	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.052482e-02	1.515	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.064746e-02	1.514	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	3.067944e-02	1.513	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.067944e-02	1.513	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.132189e-02	1.504	0	0
Ephrin signaling	R-HSA-3928664	3.763209e-02	1.424	0	0
Signaling by ERBB2	R-HSA-1227986	3.221871e-02	1.492	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.457042e-02	1.461	0	0
Adherens junctions interactions	R-HSA-418990	3.577902e-02	1.446	0	0
Gene Silencing by RNA	R-HSA-211000	3.207889e-02	1.494	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.924781e-02	1.406	0	0
IRS activation	R-HSA-74713	3.924781e-02	1.406	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.924781e-02	1.406	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.924781e-02	1.406	0	0
NGF-stimulated transcription	R-HSA-9031628	3.935517e-02	1.405	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.937942e-02	1.405	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.969302e-02	1.401	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.001093e-02	1.398	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.008189e-02	1.397	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.008189e-02	1.397	1	1
Unwinding of DNA	R-HSA-176974	4.008189e-02	1.397	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.040790e-02	1.394	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.040790e-02	1.394	0	0
Manipulation of host energy metabolism	R-HSA-9636667	4.087912e-02	1.388	0	0
Breakdown of the nuclear lamina	R-HSA-352238	4.087912e-02	1.388	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.106741e-02	1.387	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.134541e-02	1.384	0	0
Interleukin-17 signaling	R-HSA-448424	4.191372e-02	1.378	1	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.293350e-02	1.367	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.338643e-02	1.363	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.437158e-02	1.353	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.459499e-02	1.351	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.605183e-02	1.337	0	0
Nucleotide Excision Repair	R-HSA-5696398	4.747418e-02	1.324	0	0
TGFBR3 expression	R-HSA-9839394	4.950768e-02	1.305	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	4.958828e-02	1.305	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.053195e-02	1.296	0	0
Signal attenuation	R-HSA-74749	5.094486e-02	1.293	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.094486e-02	1.293	0	0
tRNA processing	R-HSA-72306	5.142838e-02	1.289	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.231111e-02	1.281	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.231111e-02	1.281	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.350346e-02	1.272	0	0
DCC mediated attractive signaling	R-HSA-418885	5.350346e-02	1.272	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.382480e-02	1.269	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.430328e-02	1.265	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.787950e-02	1.168	0	0
Regulation of TP53 Expression	R-HSA-6804754	6.787950e-02	1.168	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.787950e-02	1.168	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.787950e-02	1.168	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.787950e-02	1.168	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.787950e-02	1.168	0	0
Prolonged ERK activation events	R-HSA-169893	6.364526e-02	1.196	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.882602e-02	1.230	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.668623e-02	1.247	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.952750e-02	1.225	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	6.068528e-02	1.217	1	1
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.447742e-02	1.191	0	0
DAG and IP3 signaling	R-HSA-1489509	5.928455e-02	1.227	0	0
Signaling by TGFBR3	R-HSA-9839373	6.532763e-02	1.185	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.294483e-02	1.201	0	0
Signaling by PDGFR in disease	R-HSA-9671555	7.003866e-02	1.155	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	7.036450e-02	1.153	0	0
HCMV Infection	R-HSA-9609646	7.159699e-02	1.145	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	7.170086e-02	1.144	0	0
CREB phosphorylation	R-HSA-199920	7.170086e-02	1.144	0	0
Death Receptor Signaling	R-HSA-73887	7.398961e-02	1.131	0	0
Cell-cell junction organization	R-HSA-421270	7.448590e-02	1.128	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.479070e-02	1.126	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.479070e-02	1.126	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	7.486070e-02	1.126	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.726502e-02	1.112	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.726502e-02	1.112	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.726502e-02	1.112	1	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.798616e-02	1.108	1	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.816131e-02	1.107	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.005218e-02	1.097	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	8.053987e-02	1.094	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	8.053987e-02	1.094	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.217428e-02	1.085	0	0
NRAGE signals death through JNK	R-HSA-193648	8.274343e-02	1.082	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.277405e-02	1.082	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.004153e-01	0.998	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.004153e-01	0.998	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.004153e-01	0.998	0	0
MET activates STAT3	R-HSA-8875791	9.912906e-02	1.004	0	0
MET interacts with TNS proteins	R-HSA-8875513	9.912906e-02	1.004	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.125288e-02	1.040	0	0
SOS-mediated signalling	R-HSA-112412	9.125288e-02	1.040	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	9.206342e-02	1.036	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.084330e-01	0.965	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.084330e-01	0.965	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.084330e-01	0.965	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.000155e-01	1.000	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.000155e-01	1.000	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.000155e-01	1.000	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.140331e-01	0.943	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.082338e-02	1.042	0	0
Deadenylation of mRNA	R-HSA-429947	1.023384e-01	0.990	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.050204e-02	1.043	0	0
Interleukin-15 signaling	R-HSA-8983432	9.206342e-02	1.036	0	0
Activation of the pre-replicative complex	R-HSA-68962	9.155073e-02	1.038	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	9.206342e-02	1.036	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.050204e-02	1.043	0	0
Polo-like kinase mediated events	R-HSA-156711	1.000155e-01	1.000	0	0
DNA strand elongation	R-HSA-69190	1.126393e-01	0.948	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.000155e-01	1.000	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.155073e-02	1.038	0	0
Frs2-mediated activation	R-HSA-170968	1.084330e-01	0.965	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	9.125288e-02	1.040	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.127422e-01	0.948	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.153537e-01	0.938	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.787509e-02	1.056	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.127422e-01	0.948	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.127422e-01	0.948	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	9.497583e-02	1.022	0	0
The NLRP3 inflammasome	R-HSA-844456	1.140331e-01	0.943	0	0
Generic Transcription Pathway	R-HSA-212436	9.643917e-02	1.016	0	0
Ovarian tumor domain proteases	R-HSA-5689896	9.970490e-02	1.001	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.038191e-01	0.984	1	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.832336e-02	1.054	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.038191e-01	0.984	1	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.084330e-01	0.965	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.127422e-01	0.948	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	9.125288e-02	1.040	0	0
Interleukin-37 signaling	R-HSA-9008059	9.155073e-02	1.038	0	0
SARS-CoV Infections	R-HSA-9679506	1.082701e-01	0.965	0	0
SARS-CoV-2 Infection	R-HSA-9694516	8.865164e-02	1.052	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.165017e-01	0.934	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.166183e-01	0.933	0	0
Signaling by ALK	R-HSA-201556	1.196188e-01	0.922	0	0
DNA Repair	R-HSA-73894	1.238443e-01	0.907	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.240633e-01	0.906	0	0
G-protein beta:gamma signalling	R-HSA-397795	1.240633e-01	0.906	0	0
Regulation of KIT signaling	R-HSA-1433559	1.260040e-01	0.900	0	0
Signaling by NOTCH	R-HSA-157118	1.265012e-01	0.898	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.289325e-01	0.890	0	0
Nephrin family interactions	R-HSA-373753	1.289325e-01	0.890	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.305888e-01	0.884	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.305888e-01	0.884	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.306615e-01	0.884	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.335032e-01	0.875	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.335032e-01	0.875	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.335032e-01	0.875	0	0
ARMS-mediated activation	R-HSA-170984	1.359344e-01	0.867	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.359344e-01	0.867	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.359344e-01	0.867	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	1.359344e-01	0.867	0	0
Signaling by NOTCH3	R-HSA-9012852	1.369465e-01	0.863	0	0
HDACs deacetylate histones	R-HSA-3214815	1.369465e-01	0.863	0	0
Semaphorin interactions	R-HSA-373755	1.384178e-01	0.859	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.390875e-01	0.857	0	0
MAPK family signaling cascades	R-HSA-5683057	1.403468e-01	0.853	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.410916e-01	0.850	1	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.411297e-01	0.850	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.414756e-01	0.849	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.414756e-01	0.849	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.414756e-01	0.849	0	0
FLT3 Signaling	R-HSA-9607240	1.414756e-01	0.849	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.416581e-01	0.849	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.427583e-01	0.845	1	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.446640e-01	0.840	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.446805e-01	0.840	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.446805e-01	0.840	0	0
Signaling by EGFR	R-HSA-177929	1.467747e-01	0.833	0	0
RAF activation	R-HSA-5673000	1.485834e-01	0.828	0	0
Gap junction assembly	R-HSA-190861	1.485834e-01	0.828	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.499170e-01	0.824	1	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.530986e-01	0.815	0	0
Inflammasomes	R-HSA-622312	1.553801e-01	0.809	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.561193e-01	0.807	0	0
Switching of origins to a post-replicative state	R-HSA-69052	1.569515e-01	0.804	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.605872e-01	0.794	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.605872e-01	0.794	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	1.605872e-01	0.794	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.605872e-01	0.794	0	0
Signaling by Leptin	R-HSA-2586552	1.605872e-01	0.794	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.605872e-01	0.794	0	0
Signalling to ERKs	R-HSA-187687	1.616357e-01	0.791	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.907527e-01	0.720	0	0
MGMT-mediated DNA damage reversal	R-HSA-5657655	1.907527e-01	0.720	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.907527e-01	0.720	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.907527e-01	0.720	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.907527e-01	0.720	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.720231e-01	0.565	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.720231e-01	0.565	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.720231e-01	0.565	0	0
G2 Phase	R-HSA-68911	1.700602e-01	0.769	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.700602e-01	0.769	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	2.080156e-01	0.682	0	0
Phosphorylation of Emi1	R-HSA-176417	2.080156e-01	0.682	0	0
Signaling by RNF43 mutants	R-HSA-5340588	2.080156e-01	0.682	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.451360e-01	0.462	0	0
Defective ABCD1 causes ALD	R-HSA-5684045	3.451360e-01	0.462	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.451360e-01	0.462	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.451360e-01	0.462	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.451360e-01	0.462	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.451360e-01	0.462	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.451360e-01	0.462	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.451360e-01	0.462	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.467206e-01	0.608	0	0
G2/M DNA replication checkpoint	R-HSA-69478	2.467206e-01	0.608	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.467206e-01	0.608	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.643586e-01	0.784	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.643586e-01	0.784	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.133105e-01	0.671	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.133105e-01	0.671	0	0
Disinhibition of SNARE formation	R-HSA-114516	2.856421e-01	0.544	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.856421e-01	0.544	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	4.109099e-01	0.386	0	0
PLC-gamma1 signalling	R-HSA-167021	4.109099e-01	0.386	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.109099e-01	0.386	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.109099e-01	0.386	0	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.109099e-01	0.386	0	0
Signalling to STAT3	R-HSA-198745	4.109099e-01	0.386	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.109099e-01	0.386	0	0
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	4.109099e-01	0.386	0	0
MET activates PTPN11	R-HSA-8865999	4.109099e-01	0.386	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.109099e-01	0.386	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.849287e-01	0.733	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.409164e-01	0.618	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.062780e-01	0.686	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.062780e-01	0.686	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.062780e-01	0.686	0	0
Type I hemidesmosome assembly	R-HSA-446107	3.243468e-01	0.489	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.243468e-01	0.489	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.702327e-01	0.769	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.147357e-01	0.668	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.147357e-01	0.668	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.508584e-01	0.601	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.975446e-01	0.526	0	0
Retrograde neurotrophin signalling	R-HSA-177504	2.975446e-01	0.526	0	0
Lipophagy	R-HSA-9613354	3.624858e-01	0.441	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.624858e-01	0.441	0	0
Regulation of gap junction activity	R-HSA-191650	4.700810e-01	0.328	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	4.700810e-01	0.328	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.700810e-01	0.328	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.700810e-01	0.328	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.700810e-01	0.328	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.700810e-01	0.328	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.751828e-01	0.757	0	0
Processive synthesis on the lagging strand	R-HSA-69183	3.261827e-01	0.487	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.261827e-01	0.487	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.261827e-01	0.487	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.972009e-01	0.527	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.972009e-01	0.527	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.972009e-01	0.527	1	1
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.972009e-01	0.527	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	3.997827e-01	0.398	0	0
MAPK3 (ERK1) activation	R-HSA-110056	3.997827e-01	0.398	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.997827e-01	0.398	0	0
Folding of actin by CCT/TriC	R-HSA-390450	3.997827e-01	0.398	0	0
DNA replication initiation	R-HSA-68952	3.997827e-01	0.398	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.674711e-01	0.776	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.729508e-01	0.564	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.729508e-01	0.564	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.729508e-01	0.564	0	0
mRNA 3'-end processing	R-HSA-72187	1.904690e-01	0.720	0	0
Striated Muscle Contraction	R-HSA-390522	2.520655e-01	0.598	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.520655e-01	0.598	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.548081e-01	0.450	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.548081e-01	0.450	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.337311e-01	0.631	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.207645e-01	0.494	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.930670e-01	0.533	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.930670e-01	0.533	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.930670e-01	0.533	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.930670e-01	0.533	0	0
Translation initiation complex formation	R-HSA-72649	2.153620e-01	0.667	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	2.651674e-01	0.576	0	0
HIV Transcription Initiation	R-HSA-167161	2.651674e-01	0.576	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	2.651674e-01	0.576	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.444554e-01	0.463	0	0
FGFR2 alternative splicing	R-HSA-6803529	3.444554e-01	0.463	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.832702e-01	0.416	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.832702e-01	0.416	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.832702e-01	0.416	0	0
Signaling by APC mutants	R-HSA-4839744	4.360218e-01	0.360	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.360218e-01	0.360	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.360218e-01	0.360	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.360218e-01	0.360	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	2.414462e-01	0.617	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.339571e-01	0.476	0	0
Interleukin receptor SHC signaling	R-HSA-912526	3.681797e-01	0.434	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	2.976756e-01	0.526	0	0
Orc1 removal from chromatin	R-HSA-68949	3.051453e-01	0.515	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.051453e-01	0.515	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.918497e-01	0.407	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.710397e-01	0.327	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.710397e-01	0.327	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	4.710397e-01	0.327	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.682440e-01	0.571	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.965260e-01	0.528	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.309699e-01	0.480	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.205146e-01	0.494	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.205146e-01	0.494	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.391856e-01	0.357	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	4.391856e-01	0.357	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.478232e-01	0.459	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.647673e-01	0.438	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.516438e-01	0.454	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.939724e-01	0.532	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.673485e-01	0.435	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.673485e-01	0.435	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	4.387080e-01	0.358	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.664193e-01	0.331	0	0
Cap-dependent Translation Initiation	R-HSA-72737	3.062828e-01	0.514	0	0
Dual Incision in GG-NER	R-HSA-5696400	4.370897e-01	0.359	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	4.496948e-01	0.347	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.665056e-01	0.331	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.665056e-01	0.331	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.434426e-01	0.353	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.403651e-01	0.356	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.403651e-01	0.356	0	0
Transcription of the HIV genome	R-HSA-167172	2.883458e-01	0.540	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.129201e-01	0.672	0	0
Eukaryotic Translation Initiation	R-HSA-72613	3.062828e-01	0.514	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.856481e-01	0.731	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.576501e-01	0.339	0	0
Regulation of mitotic cell cycle	R-HSA-453276	4.576501e-01	0.339	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.905335e-01	0.720	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.151003e-01	0.502	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.856481e-01	0.731	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.738641e-01	0.562	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.665983e-01	0.436	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.972009e-01	0.527	0	0
Activation of SMO	R-HSA-5635838	3.548081e-01	0.450	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.313675e-01	0.636	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.134245e-01	0.504	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.191593e-01	0.378	0	0
RNA Polymerase III Transcription	R-HSA-74158	1.751828e-01	0.757	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.723063e-01	0.326	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.783175e-01	0.749	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.037981e-01	0.691	0	0
EGFR downregulation	R-HSA-182971	3.546005e-01	0.450	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.574337e-01	0.447	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.444554e-01	0.463	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.251700e-01	0.488	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.817683e-01	0.418	0	0
Resolution of D-Loop Structures	R-HSA-5693537	4.165916e-01	0.380	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.045734e-01	0.516	0	0
Chaperonin-mediated protein folding	R-HSA-390466	2.231706e-01	0.651	0	0
Chromosome Maintenance	R-HSA-73886	4.599247e-01	0.337	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.153840e-01	0.382	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.959751e-01	0.402	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.959751e-01	0.402	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.936964e-01	0.405	0	0
Assembly of the pre-replicative complex	R-HSA-68867	2.999560e-01	0.523	0	0
Cyclin D associated events in G1	R-HSA-69231	4.716622e-01	0.326	0	0
G1 Phase	R-HSA-69236	4.716622e-01	0.326	0	0
Synthesis of DNA	R-HSA-69239	2.007890e-01	0.697	0	0
Regulation of CDH11 function	R-HSA-9762292	3.997827e-01	0.398	0	0
PI3K/AKT activation	R-HSA-198203	3.997827e-01	0.398	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.114352e-01	0.386	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.710397e-01	0.327	0	0
Protein folding	R-HSA-391251	2.885227e-01	0.540	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.370897e-01	0.359	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.337159e-01	0.631	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.339571e-01	0.476	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.663041e-01	0.779	0	0
NTRK3 as a dependence receptor	R-HSA-9603505	2.720231e-01	0.565	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.133105e-01	0.671	0	0
VLDLR internalisation and degradation	R-HSA-8866427	2.409164e-01	0.618	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.243468e-01	0.489	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	2.508584e-01	0.601	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.261827e-01	0.487	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.207645e-01	0.494	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.681797e-01	0.434	0	0
Trafficking of AMPA receptors	R-HSA-399719	3.546005e-01	0.450	0	0
NF-kB is activated and signals survival	R-HSA-209560	4.710397e-01	0.327	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	4.617534e-01	0.336	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.589936e-01	0.445	0	0
Interleukin-2 signaling	R-HSA-9020558	4.360218e-01	0.360	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.387080e-01	0.358	0	0
Interleukin-2 family signaling	R-HSA-451927	3.793797e-01	0.421	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	2.062780e-01	0.686	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.282924e-01	0.642	0	0
Homology Directed Repair	R-HSA-5693538	2.406035e-01	0.619	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.752115e-01	0.560	0	0
Ca2+ pathway	R-HSA-4086398	3.561659e-01	0.448	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.962731e-01	0.707	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	2.824464e-01	0.549	0	0
Signaling by NOTCH4	R-HSA-9013694	2.561024e-01	0.592	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.874769e-01	0.541	0	0
Signaling by WNT in cancer	R-HSA-4791275	3.752928e-01	0.426	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.601541e-01	0.585	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.601541e-01	0.585	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.772288e-01	0.751	1	0
PTK6 Expression	R-HSA-8849473	2.856421e-01	0.544	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.849287e-01	0.733	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.243468e-01	0.489	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	2.975446e-01	0.526	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.975446e-01	0.526	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.360218e-01	0.360	0	0
Synthesis of PI	R-HSA-1483226	4.360218e-01	0.360	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.710397e-01	0.327	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.391856e-01	0.357	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.793797e-01	0.421	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.936964e-01	0.405	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.772288e-01	0.751	1	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.009812e-01	0.697	1	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.348392e-01	0.629	0	0
RNA Polymerase I Transcription	R-HSA-73864	3.056939e-01	0.515	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	4.165916e-01	0.380	0	0
Signaling by SCF-KIT	R-HSA-1433557	2.976756e-01	0.526	0	0
Signaling by NOTCH1	R-HSA-1980143	3.979024e-01	0.400	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.009812e-01	0.697	1	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.147357e-01	0.668	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.664193e-01	0.331	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.133606e-01	0.384	0	0
Oncogene Induced Senescence	R-HSA-2559585	2.874769e-01	0.541	0	0
Platelet calcium homeostasis	R-HSA-418360	1.702327e-01	0.769	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.671870e-01	0.777	0	0
ESR-mediated signaling	R-HSA-8939211	1.998026e-01	0.699	0	0
Signaling by WNT	R-HSA-195721	1.968491e-01	0.706	0	0
Signaling by PTK6	R-HSA-8848021	2.247200e-01	0.648	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.247200e-01	0.648	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.080156e-01	0.682	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.643586e-01	0.784	0	0
Inhibition of nitric oxide production	R-HSA-9636249	4.109099e-01	0.386	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.700810e-01	0.328	0	0
Co-inhibition by CTLA4	R-HSA-389513	2.738641e-01	0.562	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.114352e-01	0.386	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.979024e-01	0.400	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.070200e-01	0.390	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	3.581570e-01	0.446	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.467206e-01	0.608	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	2.975446e-01	0.526	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.832702e-01	0.416	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.387080e-01	0.358	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	2.348392e-01	0.629	0	0
p75NTR recruits signalling complexes	R-HSA-209543	2.409164e-01	0.618	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.624858e-01	0.441	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.561024e-01	0.592	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	4.159301e-01	0.381	0	0
RAF/MAP kinase cascade	R-HSA-5673001	4.327653e-01	0.364	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.348392e-01	0.629	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.396891e-01	0.469	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	3.918497e-01	0.407	0	0
Diseases of programmed cell death	R-HSA-9645723	3.334014e-01	0.477	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.345701e-01	0.630	1	0
Circadian clock	R-HSA-9909396	2.292936e-01	0.640	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.134245e-01	0.504	0	0
PLC beta mediated events	R-HSA-112043	3.107747e-01	0.508	0	0
Ion homeostasis	R-HSA-5578775	3.673485e-01	0.435	0	0
Neurexins and neuroligins	R-HSA-6794361	1.904690e-01	0.720	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.207645e-01	0.494	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.968588e-01	0.527	0	0
Calmodulin induced events	R-HSA-111933	1.751828e-01	0.757	0	0
Cellular response to chemical stress	R-HSA-9711123	2.268304e-01	0.644	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	4.636754e-01	0.334	0	0
Developmental Biology	R-HSA-1266738	4.016691e-01	0.396	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.907527e-01	0.720	0	0
Inhibition of PKR	R-HSA-169131	1.907527e-01	0.720	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.720231e-01	0.565	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	2.720231e-01	0.565	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.451360e-01	0.462	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.451360e-01	0.462	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.451360e-01	0.462	0	0
C6 deamination of adenosine	R-HSA-75102	3.451360e-01	0.462	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.451360e-01	0.462	0	0
Activation of BMF and translocation to mitochondria	R-HSA-139910	4.109099e-01	0.386	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.109099e-01	0.386	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.109099e-01	0.386	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.690611e-01	0.570	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	3.624858e-01	0.441	0	0
CaM pathway	R-HSA-111997	1.751828e-01	0.757	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.997827e-01	0.398	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.997827e-01	0.398	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.894795e-01	0.722	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.832702e-01	0.416	0	0
Bicarbonate transporters	R-HSA-425381	4.360218e-01	0.360	0	0
Signaling by AXIN mutants	R-HSA-4839735	4.710397e-01	0.327	0	0
Signaling by AMER1 mutants	R-HSA-4839748	4.710397e-01	0.327	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	3.107747e-01	0.508	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.793797e-01	0.421	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.377644e-01	0.624	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.831922e-01	0.316	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	4.434426e-01	0.353	0	0
Rab regulation of trafficking	R-HSA-9007101	2.315375e-01	0.635	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.865921e-01	0.729	0	0
Co-stimulation by CD28	R-HSA-389356	2.456218e-01	0.610	0	0
FLT3 signaling in disease	R-HSA-9682385	1.751828e-01	0.757	0	0
Pexophagy	R-HSA-9664873	3.997827e-01	0.398	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.429276e-01	0.354	0	0
PCP/CE pathway	R-HSA-4086400	4.258548e-01	0.371	0	0
PERK regulates gene expression	R-HSA-381042	4.574202e-01	0.340	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.770251e-01	0.321	0	0
Ca-dependent events	R-HSA-111996	2.813053e-01	0.551	0	0
Downstream signal transduction	R-HSA-186763	3.546005e-01	0.450	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.823294e-01	0.317	0	0
Rap1 signalling	R-HSA-392517	2.508584e-01	0.601	0	0
ERK/MAPK targets	R-HSA-198753	2.972009e-01	0.527	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.832702e-01	0.416	0	0
TBC/RABGAPs	R-HSA-8854214	2.976756e-01	0.526	0	0
TRP channels	R-HSA-3295583	4.387080e-01	0.358	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	4.844589e-01	0.315	0	0
HCMV Late Events	R-HSA-9610379	4.864096e-01	0.313	0	0
Mitochondrial biogenesis	R-HSA-1592230	3.166284e-01	0.499	0	0
G-protein mediated events	R-HSA-112040	3.985560e-01	0.400	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.804550e-01	0.744	1	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.080156e-01	0.682	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	3.624858e-01	0.441	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.624858e-01	0.441	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.348392e-01	0.629	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.444554e-01	0.463	0	0
Heme signaling	R-HSA-9707616	3.251700e-01	0.488	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.856421e-01	0.544	0	0
Smooth Muscle Contraction	R-HSA-445355	2.027569e-01	0.693	0	0
Signaling by ROBO receptors	R-HSA-376176	2.592677e-01	0.586	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.849316e-01	0.545	0	0
Platelet degranulation	R-HSA-114608	3.379852e-01	0.471	0	0
Hedgehog 'off' state	R-HSA-5610787	3.948977e-01	0.404	0	0
Toll-like Receptor Cascades	R-HSA-168898	4.625465e-01	0.335	1	0
Oligomerization of connexins into connexons	R-HSA-190704	2.720231e-01	0.565	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.080156e-01	0.682	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.133105e-01	0.671	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.700810e-01	0.328	0	0
NADE modulates death signalling	R-HSA-205025	4.700810e-01	0.328	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.348392e-01	0.629	0	0
Regulation of gene expression in beta cells	R-HSA-210745	3.134245e-01	0.504	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.959751e-01	0.402	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.618757e-01	0.335	0	0
Gluconeogenesis	R-HSA-70263	3.817683e-01	0.418	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.350288e-01	0.361	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.080156e-01	0.682	0	0
PECAM1 interactions	R-HSA-210990	4.360218e-01	0.360	0	0
PKMTs methylate histone lysines	R-HSA-3214841	2.492975e-01	0.603	0	0
Netrin-1 signaling	R-HSA-373752	3.142423e-01	0.503	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.856421e-01	0.544	0	0
Regulation of PTEN localization	R-HSA-8948747	2.856421e-01	0.544	0	0
The NLRP1 inflammasome	R-HSA-844455	4.109099e-01	0.386	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.849287e-01	0.733	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.700810e-01	0.328	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.997827e-01	0.398	0	0
LDL clearance	R-HSA-8964038	3.444554e-01	0.463	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	4.374272e-01	0.359	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.496948e-01	0.347	0	0
Viral Infection Pathways	R-HSA-9824446	4.564605e-01	0.341	0	0
Activation of ATR in response to replication stress	R-HSA-176187	2.348392e-01	0.629	0	0
Miscellaneous transport and binding events	R-HSA-5223345	2.520655e-01	0.598	0	0
Potential therapeutics for SARS	R-HSA-9679191	4.168344e-01	0.380	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.624858e-01	0.441	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.243468e-01	0.489	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.624858e-01	0.441	0	0
Interleukin-38 signaling	R-HSA-9007892	4.700810e-01	0.328	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.710397e-01	0.327	0	0
Insulin processing	R-HSA-264876	4.617534e-01	0.336	0	0
Josephin domain DUBs	R-HSA-5689877	3.997827e-01	0.398	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.832702e-01	0.416	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.239403e-01	0.650	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	4.360218e-01	0.360	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.864583e-01	0.729	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	3.089218e-01	0.510	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.409164e-01	0.618	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	4.664193e-01	0.331	0	0
IRE1alpha activates chaperones	R-HSA-381070	3.833897e-01	0.416	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.258548e-01	0.371	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.897333e-01	0.310	0	0
Nucleosome assembly	R-HSA-774815	4.897333e-01	0.310	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.908579e-01	0.309	0	0
SLC transporter disorders	R-HSA-5619102	4.920733e-01	0.308	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.929136e-01	0.307	0	0
Negative regulation of MET activity	R-HSA-6807004	4.930491e-01	0.307	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.930491e-01	0.307	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.930491e-01	0.307	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.930491e-01	0.307	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.930491e-01	0.307	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.930491e-01	0.307	0	0
Protein hydroxylation	R-HSA-9629569	4.930491e-01	0.307	0	0
Signal transduction by L1	R-HSA-445144	4.930491e-01	0.307	0	0
Cellular response to starvation	R-HSA-9711097	4.962809e-01	0.304	0	0
MET activates RAS signaling	R-HSA-8851805	5.047161e-01	0.297	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.047161e-01	0.297	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.047161e-01	0.297	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.047161e-01	0.297	0	0
Polymerase switching	R-HSA-69091	5.047161e-01	0.297	0	0
Leading Strand Synthesis	R-HSA-69109	5.047161e-01	0.297	0	0
GRB2 events in EGFR signaling	R-HSA-179812	5.047161e-01	0.297	0	0
Scavenging by Class F Receptors	R-HSA-3000484	5.047161e-01	0.297	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.047161e-01	0.297	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.047161e-01	0.297	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.047161e-01	0.297	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.047161e-01	0.297	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.047161e-01	0.297	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.047161e-01	0.297	0	0
Signaling by LTK	R-HSA-9842663	5.047161e-01	0.297	0	0
Pervasive developmental disorders	R-HSA-9005895	5.047161e-01	0.297	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.047161e-01	0.297	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.047161e-01	0.297	0	0
OAS antiviral response	R-HSA-8983711	5.047161e-01	0.297	0	0
Late endosomal microautophagy	R-HSA-9615710	5.067696e-01	0.295	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.067696e-01	0.295	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.075987e-01	0.294	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	5.075987e-01	0.294	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.075987e-01	0.294	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	5.075987e-01	0.294	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	5.075987e-01	0.294	0	0
Eukaryotic Translation Elongation	R-HSA-156842	5.155499e-01	0.288	0	0
TNF signaling	R-HSA-75893	5.160923e-01	0.287	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.160923e-01	0.287	0	0
Lagging Strand Synthesis	R-HSA-69186	5.190014e-01	0.285	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.190014e-01	0.285	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.190014e-01	0.285	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	5.233118e-01	0.281	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.233118e-01	0.281	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.233118e-01	0.281	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.233118e-01	0.281	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.233118e-01	0.281	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.233118e-01	0.281	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.233118e-01	0.281	0	0
Activation of AKT2	R-HSA-165158	5.233118e-01	0.281	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.233118e-01	0.281	0	0
Reelin signalling pathway	R-HSA-8866376	5.233118e-01	0.281	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	5.233118e-01	0.281	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	5.233118e-01	0.281	0	0
Pyrophosphate hydrolysis	R-HSA-71737	5.233118e-01	0.281	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.252299e-01	0.280	0	0
Interleukin-1 family signaling	R-HSA-446652	5.308327e-01	0.275	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.362106e-01	0.271	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.362106e-01	0.271	0	0
Stabilization of p53	R-HSA-69541	5.362106e-01	0.271	0	0
Plasma lipoprotein clearance	R-HSA-8964043	5.362106e-01	0.271	0	0
Formation of axial mesoderm	R-HSA-9796292	5.369671e-01	0.270	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.369671e-01	0.270	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.369671e-01	0.270	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.369671e-01	0.270	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.369671e-01	0.270	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.384356e-01	0.269	0	0
DNA Replication	R-HSA-69306	5.407658e-01	0.267	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.426004e-01	0.266	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.442156e-01	0.264	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.442156e-01	0.264	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.442156e-01	0.264	0	0
Dual incision in TC-NER	R-HSA-6782135	5.482100e-01	0.261	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.500187e-01	0.260	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.500187e-01	0.260	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.532603e-01	0.257	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.550926e-01	0.256	0	0
HIV Transcription Elongation	R-HSA-167169	5.550926e-01	0.256	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.550926e-01	0.256	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	5.550926e-01	0.256	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.550926e-01	0.256	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.550926e-01	0.256	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	5.550926e-01	0.256	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.596862e-01	0.252	0	0
Degradation of CDH1	R-HSA-9766229	5.596862e-01	0.252	0	0
DNA Damage Bypass	R-HSA-73893	5.596862e-01	0.252	0	0
Regulation of beta-cell development	R-HSA-186712	5.639246e-01	0.249	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.677395e-01	0.246	0	0
Removal of the Flap Intermediate	R-HSA-69166	5.677395e-01	0.246	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.677395e-01	0.246	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.677395e-01	0.246	0	0
Notch-HLH transcription pathway	R-HSA-350054	5.686428e-01	0.245	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	5.686428e-01	0.245	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.686428e-01	0.245	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	5.686428e-01	0.245	0	0
Signaling by KIT in disease	R-HSA-9669938	5.686428e-01	0.245	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.711983e-01	0.243	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.711983e-01	0.243	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.711983e-01	0.243	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.711983e-01	0.243	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.711983e-01	0.243	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.711983e-01	0.243	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.711983e-01	0.243	0	0
Signaling by MAPK mutants	R-HSA-9652817	5.711983e-01	0.243	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.711983e-01	0.243	0	0
PDE3B signalling	R-HSA-165160	5.711983e-01	0.243	0	0
PKB-mediated events	R-HSA-109703	5.711983e-01	0.243	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.711983e-01	0.243	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.711983e-01	0.243	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.711983e-01	0.243	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.711983e-01	0.243	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.711983e-01	0.243	0	0
Muscle contraction	R-HSA-397014	5.720740e-01	0.243	0	0
SARS-CoV-1 Infection	R-HSA-9678108	5.768042e-01	0.239	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.822895e-01	0.235	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.851501e-01	0.233	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.911853e-01	0.228	0	0
Integrin signaling	R-HSA-354192	5.911853e-01	0.228	0	0
Cardiogenesis	R-HSA-9733709	5.911853e-01	0.228	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.916717e-01	0.228	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.922447e-01	0.227	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.922447e-01	0.227	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.922447e-01	0.227	0	0
Growth hormone receptor signaling	R-HSA-982772	5.922447e-01	0.227	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.945770e-01	0.226	0	0
Hedgehog 'on' state	R-HSA-5632684	5.964659e-01	0.224	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.970047e-01	0.224	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.970047e-01	0.224	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.970047e-01	0.224	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.970047e-01	0.224	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	5.970047e-01	0.224	0	0
SHC1 events in EGFR signaling	R-HSA-180336	5.970047e-01	0.224	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.970047e-01	0.224	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.970047e-01	0.224	0	0
Protein methylation	R-HSA-8876725	5.970047e-01	0.224	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.970047e-01	0.224	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	5.984871e-01	0.223	0	0
Signaling by TGFB family members	R-HSA-9006936	6.082356e-01	0.216	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.090297e-01	0.215	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	6.094843e-01	0.215	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.142768e-01	0.212	0	0
Signaling by LTK in cancer	R-HSA-9842640	6.142768e-01	0.212	0	0
STAT5 Activation	R-HSA-9645135	6.142768e-01	0.212	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.142768e-01	0.212	0	0
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	6.142768e-01	0.212	0	0
MET Receptor Activation	R-HSA-6806942	6.142768e-01	0.212	0	0
Chylomicron clearance	R-HSA-8964026	6.142768e-01	0.212	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.142768e-01	0.212	0	0
CREB3 factors activate genes	R-HSA-8874211	6.142768e-01	0.212	0	0
Mitochondrial RNA degradation	R-HSA-9836573	6.149931e-01	0.211	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.149931e-01	0.211	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	6.240946e-01	0.205	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.247551e-01	0.204	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	6.247551e-01	0.204	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.247551e-01	0.204	0	0
Killing mechanisms	R-HSA-9664420	6.247551e-01	0.204	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.247551e-01	0.204	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.247551e-01	0.204	0	0
Amino acids regulate mTORC1	R-HSA-9639288	6.247816e-01	0.204	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	6.247816e-01	0.204	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	6.252672e-01	0.204	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	6.265251e-01	0.203	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.300437e-01	0.201	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.300437e-01	0.201	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.300437e-01	0.201	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.368682e-01	0.196	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.368682e-01	0.196	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.368682e-01	0.196	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.368682e-01	0.196	0	0
Interleukin-7 signaling	R-HSA-1266695	6.368682e-01	0.196	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.383965e-01	0.195	0	0
IGF1R signaling cascade	R-HSA-2428924	6.383965e-01	0.195	0	0
Ion transport by P-type ATPases	R-HSA-936837	6.383965e-01	0.195	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.485589e-01	0.188	0	0
Regulation of Apoptosis	R-HSA-169911	6.485589e-01	0.188	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.485589e-01	0.188	0	0
PI Metabolism	R-HSA-1483255	6.490299e-01	0.188	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	6.509995e-01	0.186	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.509995e-01	0.186	0	0
Synthesis of PG	R-HSA-1483148	6.509995e-01	0.186	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	6.509995e-01	0.186	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.523799e-01	0.185	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.530299e-01	0.185	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.530299e-01	0.185	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.530299e-01	0.185	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.530299e-01	0.185	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.530299e-01	0.185	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.530299e-01	0.185	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.530299e-01	0.185	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	6.530299e-01	0.185	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.530299e-01	0.185	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.530299e-01	0.185	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	6.530299e-01	0.185	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.530299e-01	0.185	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.530299e-01	0.185	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.530299e-01	0.185	0	0
VLDL clearance	R-HSA-8964046	6.530299e-01	0.185	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	6.530299e-01	0.185	0	0
CHL1 interactions	R-HSA-447041	6.530299e-01	0.185	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	6.578583e-01	0.182	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.578583e-01	0.182	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.595215e-01	0.181	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.595215e-01	0.181	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.595215e-01	0.181	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	6.660362e-01	0.177	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.697649e-01	0.174	0	0
Signaling by Hedgehog	R-HSA-5358351	6.699053e-01	0.174	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.721447e-01	0.173	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	6.752946e-01	0.171	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.757606e-01	0.170	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	6.757606e-01	0.170	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.757606e-01	0.170	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.757606e-01	0.170	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.757606e-01	0.170	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.757606e-01	0.170	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.757606e-01	0.170	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.779583e-01	0.169	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.779583e-01	0.169	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.779583e-01	0.169	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	6.779583e-01	0.169	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.779583e-01	0.169	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	6.833087e-01	0.165	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.837030e-01	0.165	0	0
IRS-mediated signalling	R-HSA-112399	6.839709e-01	0.165	0	0
Interferon gamma signaling	R-HSA-877300	6.878812e-01	0.162	0	0
RSK activation	R-HSA-444257	6.878915e-01	0.162	0	0
MET receptor recycling	R-HSA-8875656	6.878915e-01	0.162	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.878915e-01	0.162	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.878915e-01	0.162	0	0
Interleukin-23 signaling	R-HSA-9020933	6.878915e-01	0.162	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.878915e-01	0.162	0	0
Co-stimulation by ICOS	R-HSA-9927354	6.878915e-01	0.162	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.878915e-01	0.162	0	0
Interleukin-9 signaling	R-HSA-8985947	6.878915e-01	0.162	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.878915e-01	0.162	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	6.878915e-01	0.162	0	0
Nucleotide salvage defects	R-HSA-9734207	6.878915e-01	0.162	0	0
Sodium/Proton exchangers	R-HSA-425986	6.878915e-01	0.162	0	0
Adrenoceptors	R-HSA-390696	6.878915e-01	0.162	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.883058e-01	0.162	0	0
Adipogenesis	R-HSA-9843745	6.888462e-01	0.162	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	6.905744e-01	0.161	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.905744e-01	0.161	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.971696e-01	0.157	0	0
GAB1 signalosome	R-HSA-180292	6.990713e-01	0.155	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.990713e-01	0.155	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.990713e-01	0.155	0	0
PKA activation	R-HSA-163615	6.990713e-01	0.155	0	0
PKA activation in glucagon signalling	R-HSA-164378	6.990713e-01	0.155	0	0
Mismatch Repair	R-HSA-5358508	6.990713e-01	0.155	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.003203e-01	0.155	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.003203e-01	0.155	0	0
Sensory processing of sound	R-HSA-9659379	7.003647e-01	0.155	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.042990e-01	0.152	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.049375e-01	0.152	0	0
Intraflagellar transport	R-HSA-5620924	7.053561e-01	0.152	0	0
Extension of Telomeres	R-HSA-180786	7.111627e-01	0.148	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.120529e-01	0.147	0	0
Signaling by FGFR2	R-HSA-5654738	7.120529e-01	0.147	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.125870e-01	0.147	0	0
Signaling by Erythropoietin	R-HSA-9006335	7.154985e-01	0.145	0	0
mRNA Capping	R-HSA-72086	7.154985e-01	0.145	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	7.154985e-01	0.145	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	7.154985e-01	0.145	0	0
Pentose phosphate pathway	R-HSA-71336	7.162990e-01	0.145	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.162990e-01	0.145	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.192523e-01	0.143	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.192523e-01	0.143	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.192523e-01	0.143	0	0
Interleukin-21 signaling	R-HSA-9020958	7.192523e-01	0.143	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.192523e-01	0.143	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.192523e-01	0.143	0	0
mRNA Editing	R-HSA-75072	7.192523e-01	0.143	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.192523e-01	0.143	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.192523e-01	0.143	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.192523e-01	0.143	0	0
Interleukin-1 processing	R-HSA-448706	7.192523e-01	0.143	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	7.192523e-01	0.143	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.192523e-01	0.143	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.201803e-01	0.143	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.209731e-01	0.142	0	0
STING mediated induction of host immune responses	R-HSA-1834941	7.209731e-01	0.142	0	0
Maturation of nucleoprotein	R-HSA-9694631	7.209731e-01	0.142	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.241419e-01	0.140	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.241419e-01	0.140	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.241419e-01	0.140	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.241419e-01	0.140	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.241419e-01	0.140	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.292026e-01	0.137	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.316412e-01	0.136	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	7.329561e-01	0.135	0	0
PI3K Cascade	R-HSA-109704	7.334179e-01	0.135	0	0
Regulation of RAS by GAPs	R-HSA-5658442	7.334179e-01	0.135	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.334179e-01	0.135	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.367078e-01	0.133	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	7.378030e-01	0.132	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.407878e-01	0.130	0	0
Signaling by NODAL	R-HSA-1181150	7.415137e-01	0.130	0	0
Interleukin-1 signaling	R-HSA-9020702	7.453138e-01	0.128	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.463518e-01	0.127	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.463518e-01	0.127	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	7.466989e-01	0.127	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.466989e-01	0.127	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.474636e-01	0.126	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.474636e-01	0.126	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.474636e-01	0.126	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.474636e-01	0.126	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.474636e-01	0.126	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.474636e-01	0.126	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.474636e-01	0.126	0	0
Interleukin-27 signaling	R-HSA-9020956	7.474636e-01	0.126	0	0
Signaling by PDGF	R-HSA-186797	7.488606e-01	0.126	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.495572e-01	0.125	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	7.504851e-01	0.125	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.557491e-01	0.122	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.594835e-01	0.119	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.594835e-01	0.119	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.604380e-01	0.119	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.604380e-01	0.119	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	7.604380e-01	0.119	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.604380e-01	0.119	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.604380e-01	0.119	0	0
Signalling to RAS	R-HSA-167044	7.607455e-01	0.119	0	0
Basigin interactions	R-HSA-210991	7.607455e-01	0.119	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.607455e-01	0.119	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.610511e-01	0.119	0	0
Signaling by ERBB4	R-HSA-1236394	7.629011e-01	0.118	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.653202e-01	0.116	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.683507e-01	0.114	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.693354e-01	0.114	0	0
Meiotic synapsis	R-HSA-1221632	7.717763e-01	0.113	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.728415e-01	0.112	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.728415e-01	0.112	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.728415e-01	0.112	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	7.728415e-01	0.112	0	0
vRNA Synthesis	R-HSA-192814	7.728415e-01	0.112	0	0
vRNP Assembly	R-HSA-192905	7.728415e-01	0.112	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	7.728415e-01	0.112	0	0
Transport of RCbl within the body	R-HSA-9758890	7.728415e-01	0.112	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.728415e-01	0.112	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.728415e-01	0.112	0	0
Suppression of apoptosis	R-HSA-9635465	7.728415e-01	0.112	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.728415e-01	0.112	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.734312e-01	0.112	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	7.739089e-01	0.111	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.739089e-01	0.111	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.787240e-01	0.109	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.787240e-01	0.109	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.787240e-01	0.109	0	0
Immune System	R-HSA-168256	7.788342e-01	0.109	1	0
Regulation of necroptotic cell death	R-HSA-5675482	7.802660e-01	0.108	0	0
Nuclear RNA decay	R-HSA-9930044	7.802660e-01	0.108	0	0
Cellular response to hypoxia	R-HSA-1234174	7.828590e-01	0.106	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	7.854051e-01	0.105	0	0
Signaling by FGFR4	R-HSA-5654743	7.867756e-01	0.104	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.875846e-01	0.104	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.944176e-01	0.100	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.944176e-01	0.100	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.944176e-01	0.100	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.955069e-01	0.099	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.955069e-01	0.099	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.955069e-01	0.099	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	7.956705e-01	0.099	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	7.956705e-01	0.099	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.956705e-01	0.099	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	7.956705e-01	0.099	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.956705e-01	0.099	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.956705e-01	0.099	0	0
Integration of provirus	R-HSA-162592	7.956705e-01	0.099	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.963036e-01	0.099	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.963036e-01	0.099	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.990506e-01	0.097	0	0
Ub-specific processing proteases	R-HSA-5689880	8.003212e-01	0.097	0	0
Hemostasis	R-HSA-109582	8.022946e-01	0.096	0	0
Peptide chain elongation	R-HSA-156902	8.034783e-01	0.095	0	0
Telomere Maintenance	R-HSA-157579	8.047548e-01	0.094	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.057690e-01	0.094	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.066588e-01	0.093	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.078001e-01	0.093	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.078001e-01	0.093	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.078001e-01	0.093	0	0
Signaling by NOTCH2	R-HSA-1980145	8.078001e-01	0.093	0	0
Mitophagy	R-HSA-5205647	8.078001e-01	0.093	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.078001e-01	0.093	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.078001e-01	0.093	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.107479e-01	0.091	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.107479e-01	0.091	0	0
Signaling by FGFR3	R-HSA-5654741	8.107479e-01	0.091	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.107479e-01	0.091	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.111528e-01	0.091	0	0
Formation of the ureteric bud	R-HSA-9830674	8.111528e-01	0.091	0	0
Syndecan interactions	R-HSA-3000170	8.111528e-01	0.091	0	0
Disorders of transmembrane transporters	R-HSA-5619115	8.151186e-01	0.089	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.162065e-01	0.088	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.162065e-01	0.088	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.162065e-01	0.088	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.162065e-01	0.088	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.162065e-01	0.088	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.162065e-01	0.088	0	0
Interleukin-35 Signalling	R-HSA-8984722	8.162065e-01	0.088	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	8.204397e-01	0.086	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	8.204397e-01	0.086	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.204397e-01	0.086	0	0
Base Excision Repair	R-HSA-73884	8.204717e-01	0.086	0	0
Signaling by MET	R-HSA-6806834	8.209267e-01	0.086	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	8.218824e-01	0.085	0	0
Diseases of DNA repair	R-HSA-9675135	8.218824e-01	0.085	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.226052e-01	0.085	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.261100e-01	0.083	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.270031e-01	0.082	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.285324e-01	0.082	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.315843e-01	0.080	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.323637e-01	0.080	0	0
RUNX2 regulates bone development	R-HSA-8941326	8.323637e-01	0.080	0	0
Glycosphingolipid transport	R-HSA-9845576	8.323637e-01	0.080	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.346796e-01	0.078	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.346796e-01	0.078	0	0
Interleukin-6 signaling	R-HSA-1059683	8.346796e-01	0.078	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	8.346796e-01	0.078	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	8.346796e-01	0.078	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.346796e-01	0.078	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.346796e-01	0.078	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.392692e-01	0.076	0	0
Long-term potentiation	R-HSA-9620244	8.392692e-01	0.076	0	0
Tight junction interactions	R-HSA-420029	8.392692e-01	0.076	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.392692e-01	0.076	0	0
Formation of the nephric duct	R-HSA-9830364	8.392692e-01	0.076	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.436001e-01	0.074	0	0
Degradation of DVL	R-HSA-4641258	8.436001e-01	0.074	0	0
Degradation of AXIN	R-HSA-4641257	8.436001e-01	0.074	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.436001e-01	0.074	0	0
Cytoprotection by HMOX1	R-HSA-9707564	8.454621e-01	0.073	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.512969e-01	0.070	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.512969e-01	0.070	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.512969e-01	0.070	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.512969e-01	0.070	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.512969e-01	0.070	0	0
cGMP effects	R-HSA-418457	8.512969e-01	0.070	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.512969e-01	0.070	0	0
Physiological factors	R-HSA-5578768	8.512969e-01	0.070	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.512969e-01	0.070	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.512969e-01	0.070	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.515219e-01	0.070	0	0
Metalloprotease DUBs	R-HSA-5689901	8.518560e-01	0.070	0	0
Linoleic acid (LA) metabolism	R-HSA-2046105	8.518560e-01	0.070	0	0
Urea cycle	R-HSA-70635	8.518560e-01	0.070	0	0
Suppression of phagosomal maturation	R-HSA-9637687	8.518560e-01	0.070	0	0
Formation of paraxial mesoderm	R-HSA-9793380	8.533455e-01	0.069	0	0
MET promotes cell motility	R-HSA-8875878	8.541774e-01	0.068	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.541774e-01	0.068	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.541774e-01	0.068	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.541774e-01	0.068	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.541774e-01	0.068	0	0
Opioid Signalling	R-HSA-111885	8.566702e-01	0.067	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.582015e-01	0.066	0	0
Meiosis	R-HSA-1500620	8.602657e-01	0.065	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.635375e-01	0.064	0	0
Cristae formation	R-HSA-8949613	8.635375e-01	0.064	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.635375e-01	0.064	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.641239e-01	0.063	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.641239e-01	0.063	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.662448e-01	0.062	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.662448e-01	0.062	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.662448e-01	0.062	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.662448e-01	0.062	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.662448e-01	0.062	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.662448e-01	0.062	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.662448e-01	0.062	0	0
p38MAPK events	R-HSA-171007	8.662448e-01	0.062	0	0
Spry regulation of FGF signaling	R-HSA-1295596	8.662448e-01	0.062	0	0
DNA Damage Reversal	R-HSA-73942	8.662448e-01	0.062	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.694549e-01	0.061	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.710936e-01	0.060	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.734684e-01	0.059	0	0
Generation of second messenger molecules	R-HSA-202433	8.734684e-01	0.059	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.743684e-01	0.058	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.743684e-01	0.058	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.743684e-01	0.058	0	0
Neutrophil degranulation	R-HSA-6798695	8.774608e-01	0.057	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	8.778037e-01	0.057	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.796909e-01	0.056	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.796909e-01	0.056	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.796909e-01	0.056	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.796909e-01	0.056	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.796909e-01	0.056	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	8.796909e-01	0.056	0	0
Differentiation of T cells	R-HSA-9945266	8.796909e-01	0.056	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.796909e-01	0.056	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.796909e-01	0.056	0	0
Negative regulation of FLT3	R-HSA-9706369	8.796909e-01	0.056	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.822389e-01	0.054	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.822389e-01	0.054	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.822389e-01	0.054	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.832635e-01	0.054	0	0
Integration of energy metabolism	R-HSA-163685	8.833215e-01	0.054	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.844017e-01	0.053	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.844017e-01	0.053	0	0
DARPP-32 events	R-HSA-180024	8.844017e-01	0.053	0	0
Co-inhibition by PD-1	R-HSA-389948	8.858013e-01	0.053	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.878233e-01	0.052	0	0
Signaling by FGFR	R-HSA-190236	8.888952e-01	0.051	0	0
Regulation of insulin secretion	R-HSA-422356	8.888952e-01	0.051	0	0
Intra-Golgi traffic	R-HSA-6811438	8.904635e-01	0.050	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.904635e-01	0.050	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.917860e-01	0.050	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.917860e-01	0.050	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.917860e-01	0.050	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.917860e-01	0.050	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.917860e-01	0.050	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.917860e-01	0.050	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.927208e-01	0.049	0	0
DAP12 signaling	R-HSA-2424491	8.936883e-01	0.049	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.936883e-01	0.049	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.936883e-01	0.049	0	0
Gastrulation	R-HSA-9758941	8.967877e-01	0.047	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.969011e-01	0.047	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.981694e-01	0.047	0	0
G alpha (z) signalling events	R-HSA-418597	8.995622e-01	0.046	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.022767e-01	0.045	0	0
Cargo concentration in the ER	R-HSA-5694530	9.022767e-01	0.045	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.026658e-01	0.044	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.026658e-01	0.044	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.026658e-01	0.044	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	9.026658e-01	0.044	0	0
Glycogen storage diseases	R-HSA-3229121	9.026658e-01	0.044	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.026658e-01	0.044	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.031957e-01	0.044	0	0
Selenocysteine synthesis	R-HSA-2408557	9.045992e-01	0.044	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.053835e-01	0.043	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.053835e-01	0.043	0	0
Signaling by FGFR1	R-HSA-5654736	9.060157e-01	0.043	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.083230e-01	0.042	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.102136e-01	0.041	0	0
Proteasome assembly	R-HSA-9907900	9.121319e-01	0.040	0	0
RMTs methylate histone arginines	R-HSA-3214858	9.121319e-01	0.040	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.124523e-01	0.040	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.124523e-01	0.040	0	0
Tie2 Signaling	R-HSA-210993	9.124523e-01	0.040	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	9.124523e-01	0.040	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	9.124523e-01	0.040	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.124523e-01	0.040	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.130526e-01	0.040	0	0
Signaling by Insulin receptor	R-HSA-74752	9.131778e-01	0.039	0	0
Viral mRNA Translation	R-HSA-192823	9.139895e-01	0.039	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.145275e-01	0.039	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.175430e-01	0.037	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.175430e-01	0.037	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.184397e-01	0.037	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.184397e-01	0.037	0	0
Somitogenesis	R-HSA-9824272	9.184397e-01	0.037	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.212554e-01	0.036	0	0
Regulation of signaling by CBL	R-HSA-912631	9.212554e-01	0.036	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.212554e-01	0.036	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.212554e-01	0.036	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.212554e-01	0.036	0	0
Specification of the neural plate border	R-HSA-9834899	9.212554e-01	0.036	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	9.243069e-01	0.034	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.243069e-01	0.034	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	9.243069e-01	0.034	0	0
rRNA processing	R-HSA-72312	9.243851e-01	0.034	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.247947e-01	0.034	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.247947e-01	0.034	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.247947e-01	0.034	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.264838e-01	0.033	0	0
tRNA Aminoacylation	R-HSA-379724	9.282945e-01	0.032	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.282945e-01	0.032	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.291737e-01	0.032	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.291737e-01	0.032	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.291737e-01	0.032	0	0
Glycogen synthesis	R-HSA-3322077	9.291737e-01	0.032	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.291737e-01	0.032	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.291737e-01	0.032	0	0
Formation of definitive endoderm	R-HSA-9823730	9.291737e-01	0.032	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.291737e-01	0.032	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.298306e-01	0.032	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	9.305448e-01	0.031	0	0
eNOS activation	R-HSA-203615	9.305448e-01	0.031	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.305448e-01	0.031	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.305448e-01	0.031	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.314420e-01	0.031	0	0
Ribosome-associated quality control	R-HSA-9948299	9.362143e-01	0.029	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.362963e-01	0.029	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.362963e-01	0.029	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.362963e-01	0.029	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.362963e-01	0.029	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.362963e-01	0.029	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.362963e-01	0.029	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.362963e-01	0.029	0	0
Stimuli-sensing channels	R-HSA-2672351	9.375523e-01	0.028	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.414355e-01	0.026	0	0
PRC2 methylates histones and DNA	R-HSA-212300	9.415899e-01	0.026	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.415899e-01	0.026	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.427029e-01	0.026	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.427029e-01	0.026	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.427029e-01	0.026	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.427029e-01	0.026	0	0
Serine metabolism	R-HSA-977347	9.427029e-01	0.026	0	0
TCR signaling	R-HSA-202403	9.440394e-01	0.025	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.452999e-01	0.024	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.464653e-01	0.024	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.467965e-01	0.024	0	0
Protein localization	R-HSA-9609507	9.482899e-01	0.023	0	0
Meiotic recombination	R-HSA-912446	9.483415e-01	0.023	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.483415e-01	0.023	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.484656e-01	0.023	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.484656e-01	0.023	0	0
Ethanol oxidation	R-HSA-71384	9.484656e-01	0.023	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.484656e-01	0.023	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.484656e-01	0.023	0	0
PPARA activates gene expression	R-HSA-1989781	9.530500e-01	0.021	0	0
Ion channel transport	R-HSA-983712	9.535376e-01	0.021	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.536490e-01	0.021	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.536490e-01	0.021	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.536490e-01	0.021	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.536490e-01	0.021	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.536490e-01	0.021	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.536490e-01	0.021	0	0
Carnitine shuttle	R-HSA-200425	9.536490e-01	0.021	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.550767e-01	0.020	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.583113e-01	0.018	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.583113e-01	0.018	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.583113e-01	0.018	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.583113e-01	0.018	0	0
Complex III assembly	R-HSA-9865881	9.583113e-01	0.018	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.583113e-01	0.018	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.584772e-01	0.018	1	0
Parasitic Infection Pathways	R-HSA-9824443	9.585644e-01	0.018	0	0
Leishmania infection	R-HSA-9658195	9.585644e-01	0.018	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.588689e-01	0.018	0	0
Diseases of Immune System	R-HSA-5260271	9.588689e-01	0.018	0	0
Regulated Necrosis	R-HSA-5218859	9.591445e-01	0.018	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.606072e-01	0.017	0	0
RSV-host interactions	R-HSA-9833110	9.612217e-01	0.017	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.623530e-01	0.017	0	0
Maturation of spike protein	R-HSA-9694548	9.623530e-01	0.017	0	0
Neuronal System	R-HSA-112316	9.623938e-01	0.017	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.625049e-01	0.017	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.625049e-01	0.017	0	0
Hyaluronan degradation	R-HSA-2160916	9.625049e-01	0.017	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.625049e-01	0.017	0	0
Laminin interactions	R-HSA-3000157	9.625049e-01	0.017	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.632810e-01	0.016	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.636166e-01	0.016	0	0
Adaptive Immune System	R-HSA-1280218	9.661497e-01	0.015	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.662768e-01	0.015	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.662768e-01	0.015	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.662768e-01	0.015	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.662768e-01	0.015	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.662768e-01	0.015	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.684898e-01	0.014	0	0
Leishmania phagocytosis	R-HSA-9664417	9.687459e-01	0.014	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.687459e-01	0.014	0	0
Parasite infection	R-HSA-9664407	9.687459e-01	0.014	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.696696e-01	0.013	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.696696e-01	0.013	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.696696e-01	0.013	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.696696e-01	0.013	0	0
Defective pyroptosis	R-HSA-9710421	9.711849e-01	0.013	0	0
Peroxisomal protein import	R-HSA-9033241	9.725298e-01	0.012	0	0
Cardiac conduction	R-HSA-5576891	9.725639e-01	0.012	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.727211e-01	0.012	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.727211e-01	0.012	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.727211e-01	0.012	0	0
Pyrimidine salvage	R-HSA-73614	9.727211e-01	0.012	0	0
Pyroptosis	R-HSA-5620971	9.727211e-01	0.012	0	0
DAP12 interactions	R-HSA-2172127	9.736568e-01	0.012	0	0
Amine ligand-binding receptors	R-HSA-375280	9.736568e-01	0.012	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.746156e-01	0.011	0	0
Metabolism of polyamines	R-HSA-351202	9.746554e-01	0.011	0	0
DNA methylation	R-HSA-5334118	9.754658e-01	0.011	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.754658e-01	0.011	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.759232e-01	0.011	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.762838e-01	0.010	1	1
ABC-family proteins mediated transport	R-HSA-382556	9.765130e-01	0.010	0	0
ER-Phagosome pathway	R-HSA-1236974	9.773147e-01	0.010	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.779345e-01	0.010	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.779345e-01	0.010	0	0
Neurotransmitter clearance	R-HSA-112311	9.779345e-01	0.010	0	0
Mitochondrial protein import	R-HSA-1268020	9.784469e-01	0.009	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.784469e-01	0.009	0	0
Developmental Cell Lineages	R-HSA-9734767	9.785179e-01	0.009	0	0
Downstream TCR signaling	R-HSA-202424	9.788513e-01	0.009	0	0
Translation of Structural Proteins	R-HSA-9694635	9.789300e-01	0.009	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.801549e-01	0.009	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.803799e-01	0.009	0	0
Cholesterol biosynthesis	R-HSA-191273	9.804578e-01	0.009	0	0
ABC transporter disorders	R-HSA-5619084	9.804578e-01	0.009	0	0
GPER1 signaling	R-HSA-9634597	9.816465e-01	0.008	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.821520e-01	0.008	0	0
DAG1 glycosylations	R-HSA-8931838	9.821520e-01	0.008	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.827354e-01	0.008	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.828969e-01	0.007	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.828969e-01	0.007	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	9.831777e-01	0.007	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.831777e-01	0.007	0	0
Azathioprine ADME	R-HSA-9748787	9.847031e-01	0.007	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.847031e-01	0.007	0	0
Platelet homeostasis	R-HSA-418346	9.853110e-01	0.006	0	0
Phospholipid metabolism	R-HSA-1483257	9.854470e-01	0.006	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.855638e-01	0.006	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.855638e-01	0.006	0	0
Kidney development	R-HSA-9830369	9.857022e-01	0.006	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.870169e-01	0.006	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.870169e-01	0.006	0	0
Hyaluronan metabolism	R-HSA-2142845	9.870169e-01	0.006	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.870169e-01	0.006	0	0
RA biosynthesis pathway	R-HSA-5365859	9.870169e-01	0.006	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.870169e-01	0.006	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.870169e-01	0.006	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.870169e-01	0.006	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.871886e-01	0.006	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.883237e-01	0.005	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.883237e-01	0.005	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.883237e-01	0.005	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.883801e-01	0.005	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.888607e-01	0.005	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.894022e-01	0.005	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.894991e-01	0.005	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.894991e-01	0.005	0	0
Translation	R-HSA-72766	9.901023e-01	0.004	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.905562e-01	0.004	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.905562e-01	0.004	0	0
Cleavage of the damaged purine	R-HSA-110331	9.905562e-01	0.004	0	0
Metabolism of folate and pterines	R-HSA-196757	9.905562e-01	0.004	0	0
Neddylation	R-HSA-8951664	9.906750e-01	0.004	0	0
Depurination	R-HSA-73927	9.915070e-01	0.004	0	0
Purine salvage	R-HSA-74217	9.915070e-01	0.004	0	0
Synthesis of PA	R-HSA-1483166	9.919695e-01	0.004	0	0
RAS processing	R-HSA-9648002	9.923621e-01	0.003	0	0
Glycogen metabolism	R-HSA-8982491	9.931311e-01	0.003	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.931311e-01	0.003	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.933317e-01	0.003	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.938228e-01	0.003	0	0
RAB geranylgeranylation	R-HSA-8873719	9.939251e-01	0.003	0	0
Peptide hormone metabolism	R-HSA-2980736	9.940771e-01	0.003	0	0
Interleukin-10 signaling	R-HSA-6783783	9.943379e-01	0.002	0	0
Reproduction	R-HSA-1474165	9.944302e-01	0.002	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.944448e-01	0.002	0	0
Heme biosynthesis	R-HSA-189451	9.944448e-01	0.002	0	0
Translation of Structural Proteins	R-HSA-9683701	9.944448e-01	0.002	0	0
Nucleotide salvage	R-HSA-8956321	9.944667e-01	0.002	0	0
Aquaporin-mediated transport	R-HSA-445717	9.944667e-01	0.002	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.950043e-01	0.002	0	0
Depyrimidination	R-HSA-73928	9.950043e-01	0.002	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.951981e-01	0.002	0	0
Complex I biogenesis	R-HSA-6799198	9.954117e-01	0.002	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.955074e-01	0.002	0	0
Infectious disease	R-HSA-5663205	9.957315e-01	0.002	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.959599e-01	0.002	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.959599e-01	0.002	0	0
Surfactant metabolism	R-HSA-5683826	9.959599e-01	0.002	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.962930e-01	0.002	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.967328e-01	0.001	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.967328e-01	0.001	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.968510e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.970453e-01	0.001	0	0
Synthesis of PC	R-HSA-1483191	9.970619e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.971373e-01	0.001	0	0
Metal ion SLC transporters	R-HSA-425410	9.973579e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.973993e-01	0.001	0	0
Pyruvate metabolism	R-HSA-70268	9.976170e-01	0.001	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.976241e-01	0.001	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.977322e-01	0.001	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.978439e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.978439e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.979746e-01	0.001	0	0
Purine catabolism	R-HSA-74259	9.980394e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.980787e-01	0.001	0	0
The phototransduction cascade	R-HSA-2514856	9.980787e-01	0.001	0	0
Neurotransmitter release cycle	R-HSA-112310	9.981688e-01	0.001	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.982723e-01	0.001	0	0
Protein ubiquitination	R-HSA-8852135	9.985269e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.985269e-01	0.001	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.985848e-01	0.001	0	0
Glucuronidation	R-HSA-156588	9.986030e-01	0.001	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.986060e-01	0.001	0	0
Paracetamol ADME	R-HSA-9753281	9.987438e-01	0.001	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.988074e-01	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.988944e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.989055e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.989843e-01	0.000	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.989940e-01	0.000	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.990867e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.991020e-01	0.000	0	0
Amyloid fiber formation	R-HSA-977225	9.991711e-01	0.000	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.991787e-01	0.000	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.992615e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.992796e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.993792e-01	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.996491e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.996845e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.996849e-01	0.000	0	0
Disease	R-HSA-1643685	9.997427e-01	0.000	0	0
ECM proteoglycans	R-HSA-3000178	9.997706e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.997706e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.997706e-01	0.000	0	0
Collagen formation	R-HSA-1474290	9.998064e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.998146e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.998333e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.998432e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.998502e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998556e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998779e-01	0.000	0	0
Integrin cell surface interactions	R-HSA-216083	9.998911e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999021e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999208e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999228e-01	0.000	1	0
G alpha (q) signalling events	R-HSA-416476	9.999447e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.999470e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999475e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999475e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999542e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999792e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999822e-01	0.000	0	0
Potassium Channels	R-HSA-1296071	9.999884e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999955e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999963e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999969e-01	0.000	0	0
G alpha (s) signalling events	R-HSA-418555	9.999973e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999974e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999979e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999979e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999986e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999993e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999996e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999996e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999997e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999998e-01	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000	0	0
Keratinization	R-HSA-6805567	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0