BRSK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A6NKT7	S978	Sugiyama	RGPD3 RGP3	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O00273	S37	Sugiyama	DFFA DFF1 DFF45 H13	TLKPCLLRRNysREQHGVAAsCLEDLRSKACDILAIDKSLT
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14715	S977	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14974	S445	Sugiyama	PPP1R12A MBS MYPT1	EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O43815	S229	Sugiyama	STRN	TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O94885	T460	Sugiyama	SASH1 KIAA0790 PEPE1	IKsPtASRISLGKKVKSVKEtMRKRMSKKYSSSVSEQDsGL
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95714	S2928	Sugiyama	HERC2	ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05423	S250	Sugiyama	POLR3D BN51 BN51T	AKMKAPPKAARKTPGLPKDVsVAELLRELSLTKEEELLFLQ
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DJD0	S962	Sugiyama	RGPD1 RANBP2L6 RGP1	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSG
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P10636	S579	GPS6\|EPSD	MAPT MAPTL MTBT1 TAU	RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P12004	S172	Sugiyama	PCNA	sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16949	S46	Sugiyama	STMN1 C1orf215 LAP18 OP18	PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615	S51	Sugiyama	NELFE RD RDBP	ALKKQSSSSTTSQGGVKRsLsEQPVMDTATATEQAKQLVKS
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22059	S240	Sugiyama	OSBP OSBP1	DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27797	S53	Sugiyama	CALR CRTC	WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P30291	S642	GPS6\|iPTMNet\|EPSD	WEE1	STTQSNRTSRLIGKKMNRSVsLTIY________________
P30307	S216	iPTMNet	CDC25C	EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31943	S23	Sugiyama	HNRNPH1 HNRPH HNRPH1	LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P35221	S641	Sugiyama	CTNNA1	GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49792	S1953	Sugiyama	RANBP2 NUP358	GRGVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSG
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P49815	S1387	EPSD\|PSP	TSC2 TSC4	GGRPsVDLsFQPsQPLsKssssPELQtLQDILGDPGDKADV
P52565	S174	PSP	ARHGDIA GDIA1	EEyEFLtPVEEAPKGMLARGsYsIKSRFTDDDKTDHLSWEW
P52594	S293	Sugiyama	AGFG1 HRB RAB RIP	GSAASVNANFAHFDNFPKsssADFGtFNTsQSHQTASAVSK
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00536	S12	EPSD\|PSP	CDK16 PCTAIRE1 PCTK1	_________MDRMKKIKRQLsMTLRGGRGIDKTNGAPEQIG
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q13131	T183	SIGNOR\|EPSD\|PSP	PRKAA1 AMPK1	NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13464	S576	Sugiyama	ROCK1	TESDTAVRLRKSHTEMSKSIsQLESLNRELQERNRILENSK
Q13615	S613	Sugiyama	MTMR3 KIAA0371 ZFYVE10	YPAPGTSPDDPPLSRLPKtRsyDNLttACDNTVPLASRRCs
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15751	S1512	Sugiyama	HERC1	LtAESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRR
Q16531	T1125	Sugiyama	DDB1 XAP1	MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z3J3	S978	Sugiyama	RGPD4 RGP4	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSG
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWQ3	S367	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	QEDEDLPPRNEIDPPRKRVDsPMLNRHGKRRPERKsMEVLS
Q8IWQ3	S382	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	RKRVDsPMLNRHGKRRPERKsMEVLSVtDGGsPVPARRAIE
Q8IWQ3	S393	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	HGKRRPERKsMEVLSVtDGGsPVPARRAIEMAQHGQRsRsI
Q8IWQ3	S410	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	DGGsPVPARRAIEMAQHGQRsRsIsGASSGLStsPLssPRV
Q8IWQ3	S423	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	MAQHGQRsRsIsGASSGLStsPLssPRVtPHPsPRGsPLPt
Q8IWQ3	S426	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	HGQRsRsIsGASSGLStsPLssPRVtPHPsPRGsPLPtPKG
Q8IWQ3	S427	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	GQRsRsIsGASSGLStsPLssPRVtPHPsPRGsPLPtPKGT
Q8IWQ3	S513	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	HRRKLQVPtPEEMSNLtPEssPELAKKSWFGNFISLEKEEQ
Q8IWQ3	T389	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	MLNRHGKRRPERKsMEVLSVtDGGsPVPARRAIEMAQHGQR
Q8IWQ3	T501	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	SIKNSFLGsPRFHRRKLQVPtPEEMSNLtPEssPELAKKSW
Q8IWQ3	T509	Sugiyama	BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12	sPRFHRRKLQVPtPEEMSNLtPEssPELAKKSWFGNFISLE
Q8WUF5	S102	Sugiyama	PPP1R13L IASPP NKIP1 PPP1R13BL RAI	RGsPRKAATDGADtPFGRsEsAPtLHPysPLsPKGRPssPR
Q8WWI1	S706	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WWI1	T932	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q93045	S80	Sugiyama	STMN2 SCG10 SCGN10	PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA
Q96JJ7	S268	Sugiyama	TMX3 KIAA1830 TXNDC10	LVALAVIDEKNTSVEHTRLKsIIQEVARDYRDLFHRDFQFG
Q96L92	S51	Sugiyama	SNX27 KIAA0488 My014	AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q99666	S977	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GRGVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSG
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9NQP4	S125	Sugiyama	PFDN4 PFD4	VEsIQRVLADLKVQLYAKFGsNINLEADEs___________
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NWS0	S175	Sugiyama	PIH1D1 NOP17	NLQLNPEWRMMKNRPFMGsIsQQNIRSEQRPRIQELGDLyt
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UPU5	S2047	Sugiyama	USP24 KIAA1057	VRRRYWNAYMLFYQRVSDQNsPVLPKKSRVSVVRQEAEDLs
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y450	S69	Sugiyama	HBS1L HBS1 KIAA1038	sVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDHMR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	5.652970e-08	7.248
Cell Cycle	R-HSA-1640170	2.913894e-07	6.536
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.283135e-06	5.892
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.247493e-06	5.904
Cell Cycle, Mitotic	R-HSA-69278	3.378763e-06	5.471
Mitotic Prometaphase	R-HSA-68877	5.579935e-06	5.253
Axon guidance	R-HSA-422475	7.865633e-06	5.104
Mitotic Spindle Checkpoint	R-HSA-69618	1.787698e-05	4.748
Cell Cycle Checkpoints	R-HSA-69620	2.508680e-05	4.601
Amplification of signal from the kinetochores	R-HSA-141424	3.323975e-05	4.478
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.323975e-05	4.478
Nervous system development	R-HSA-9675108	9.605478e-05	4.017
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.927576e-04	3.715
NRAGE signals death through JNK	R-HSA-193648	2.267011e-04	3.645
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.796771e-04	3.553
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.102236e-04	3.508
G alpha (12/13) signalling events	R-HSA-416482	2.975385e-04	3.526
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.388701e-04	3.470
Regulation of TP53 Activity	R-HSA-5633007	3.648889e-04	3.438
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.925091e-04	3.406
Centrosome maturation	R-HSA-380287	4.317273e-04	3.365
Intracellular signaling by second messengers	R-HSA-9006925	4.525849e-04	3.344
Neurodegenerative Diseases	R-HSA-8863678	4.939312e-04	3.306
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.939312e-04	3.306
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.082261e-04	3.294
Long-term potentiation	R-HSA-9620244	6.550012e-04	3.184
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.188910e-04	3.143
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.188910e-04	3.143
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.949836e-04	3.100
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.033686e-03	2.986
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.033686e-03	2.986
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.048468e-03	2.979
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.084902e-03	2.965
Mitotic G2-G2/M phases	R-HSA-453274	1.055696e-03	2.976
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.212946e-03	2.916
Post NMDA receptor activation events	R-HSA-438064	1.316791e-03	2.880
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.401154e-03	2.854
Integrin signaling	R-HSA-354192	1.520881e-03	2.818
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.570241e-03	2.804
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.664746e-03	2.779
Transcriptional Regulation by E2F6	R-HSA-8953750	2.339564e-03	2.631
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.442599e-03	2.612
G2/M Transition	R-HSA-69275	2.636250e-03	2.579
PIP3 activates AKT signaling	R-HSA-1257604	2.586770e-03	2.587
TRP channels	R-HSA-3295583	2.686578e-03	2.571
M Phase	R-HSA-68886	2.738282e-03	2.563
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.758544e-03	2.559
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.837935e-03	2.547
AURKA Activation by TPX2	R-HSA-8854518	2.979467e-03	2.526
Muscle contraction	R-HSA-397014	2.963315e-03	2.528
Activation of RAC1	R-HSA-428540	3.089814e-03	2.510
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.118545e-03	2.506
Separation of Sister Chromatids	R-HSA-2467813	3.183335e-03	2.497
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.309963e-03	2.480
RET signaling	R-HSA-8853659	3.469277e-03	2.460
Apoptotic execution phase	R-HSA-75153	3.875161e-03	2.412
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.282738e-03	2.368
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.282738e-03	2.368
Activation of ATR in response to replication stress	R-HSA-176187	4.247088e-03	2.372
Neurexins and neuroligins	R-HSA-6794361	4.288014e-03	2.368
Signaling by LTK	R-HSA-9842663	4.370140e-03	2.360
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.316676e-03	2.365
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.709587e-03	2.327
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.933550e-03	2.307
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.048053e-03	2.297
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.182767e-03	2.285
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.182767e-03	2.285
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.412884e-03	2.267
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.800138e-03	2.237
Signaling by ERBB2	R-HSA-1227986	6.148831e-03	2.211
Netrin-1 signaling	R-HSA-373752	6.673943e-03	2.176
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.894344e-03	2.162
Signaling by NTRKs	R-HSA-166520	6.996102e-03	2.155
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	7.132420e-03	2.147
Transcriptional activation of p53 responsive genes	R-HSA-69560	7.132420e-03	2.147
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.594750e-03	2.119
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.430423e-03	2.129
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.798379e-03	2.108
Autophagy	R-HSA-9612973	7.980918e-03	2.098
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.040285e-03	2.095
Polo-like kinase mediated events	R-HSA-156711	9.065038e-03	2.043
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.065038e-03	2.043
Notch-HLH transcription pathway	R-HSA-350054	9.465536e-03	2.024
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.763473e-03	2.010
Signaling by FGFR1 in disease	R-HSA-5655302	9.763473e-03	2.010
Potassium Channels	R-HSA-1296071	9.513740e-03	2.022
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.475172e-03	2.023
PI Metabolism	R-HSA-1483255	9.402056e-03	2.027
DNA Double-Strand Break Repair	R-HSA-5693532	1.045521e-02	1.981
Phase 0 - rapid depolarisation	R-HSA-5576892	1.146482e-02	1.941
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.199952e-02	1.921
Signaling by GSK3beta mutants	R-HSA-5339716	1.209622e-02	1.917
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.224117e-02	1.912
Cardiac conduction	R-HSA-5576891	1.195556e-02	1.922
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.415100e-02	1.849
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.415100e-02	1.849
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.415100e-02	1.849
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.415100e-02	1.849
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.429969e-02	1.845
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.295281e-02	1.888
Nephrin family interactions	R-HSA-373753	1.429969e-02	1.845
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.455186e-02	1.837
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.608851e-02	1.793
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.608851e-02	1.793
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.608851e-02	1.793
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.608851e-02	1.793
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.608851e-02	1.793
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.608851e-02	1.793
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.537240e-02	1.813
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.537240e-02	1.813
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.484340e-02	1.828
Homology Directed Repair	R-HSA-5693538	1.686099e-02	1.773
G2/M DNA damage checkpoint	R-HSA-69473	1.661030e-02	1.780
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.633789e-02	1.787
Mitotic Anaphase	R-HSA-68882	1.536305e-02	1.814
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.630494e-02	1.788
Rab regulation of trafficking	R-HSA-9007101	1.550763e-02	1.809
Macroautophagy	R-HSA-1632852	1.711231e-02	1.767
Sema4D in semaphorin signaling	R-HSA-400685	1.717695e-02	1.765
HDMs demethylate histones	R-HSA-3214842	1.717695e-02	1.765
Inactivation of CDC42 and RAC1	R-HSA-428543	1.811915e-02	1.742
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.811915e-02	1.742
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.859838e-02	1.731
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.798139e-02	1.745
Semaphorin interactions	R-HSA-373755	1.855432e-02	1.732
FLT3 Signaling	R-HSA-9607240	1.914216e-02	1.718
Programmed Cell Death	R-HSA-5357801	1.790475e-02	1.747
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.811915e-02	1.742
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.993658e-02	1.700
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.993658e-02	1.700
Signaling downstream of RAS mutants	R-HSA-9649948	1.993658e-02	1.700
Signaling by RAS mutants	R-HSA-6802949	1.993658e-02	1.700
Transcriptional Regulation by TP53	R-HSA-3700989	2.054273e-02	1.687
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.055297e-02	1.687
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.055297e-02	1.687
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.173220e-02	1.663
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.173220e-02	1.663
Cellular response to heat stress	R-HSA-3371556	2.148888e-02	1.668
Diseases of programmed cell death	R-HSA-9645723	2.180822e-02	1.661
p75 NTR receptor-mediated signalling	R-HSA-193704	2.263571e-02	1.645
Signaling by RAF1 mutants	R-HSA-9656223	2.198816e-02	1.658
Signaling by WNT in cancer	R-HSA-4791275	2.268412e-02	1.644
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.317805e-02	1.635
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.620345e-02	1.582
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.620345e-02	1.582
CREB phosphorylation	R-HSA-199920	2.707925e-02	1.567
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.675436e-02	1.573
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.583556e-02	1.588
Interaction between L1 and Ankyrins	R-HSA-445095	2.438236e-02	1.613
Voltage gated Potassium channels	R-HSA-1296072	2.416592e-02	1.617
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.546898e-02	1.594
Death Receptor Signaling	R-HSA-73887	2.879898e-02	1.541
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.930353e-02	1.533
Chromatin modifying enzymes	R-HSA-3247509	2.924768e-02	1.534
Oncogenic MAPK signaling	R-HSA-6802957	2.691594e-02	1.570
Protein-protein interactions at synapses	R-HSA-6794362	2.691594e-02	1.570
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.411135e-02	1.618
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.642789e-02	1.578
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.642789e-02	1.578
FGFR1 mutant receptor activation	R-HSA-1839124	2.642789e-02	1.578
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.813311e-02	1.551
Signaling by ALK in cancer	R-HSA-9700206	2.813311e-02	1.551
Transcriptional Regulation by MECP2	R-HSA-8986944	2.863901e-02	1.543
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.059362e-02	1.514
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.176906e-02	1.498
Signaling by APC mutants	R-HSA-4839744	3.213931e-02	1.493
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.213931e-02	1.493
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.213931e-02	1.493
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.213931e-02	1.493
Signaling by EGFR	R-HSA-177929	3.251502e-02	1.488
Ion homeostasis	R-HSA-5578775	3.251502e-02	1.488
DCC mediated attractive signaling	R-HSA-418885	3.328381e-02	1.478
Beta-catenin phosphorylation cascade	R-HSA-196299	3.328381e-02	1.478
Signaling by ROBO receptors	R-HSA-376176	3.347349e-02	1.475
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.520219e-02	1.453
Interleukin-2 family signaling	R-HSA-451927	3.614790e-02	1.442
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.753446e-02	1.426
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.094024e-02	1.388
HSF1-dependent transactivation	R-HSA-3371571	3.652775e-02	1.437
IGF1R signaling cascade	R-HSA-2428924	3.941677e-02	1.404
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.753446e-02	1.426
DAG and IP3 signaling	R-HSA-1489509	3.654229e-02	1.437
Diseases of DNA repair	R-HSA-9675135	4.104884e-02	1.387
Sodium/Calcium exchangers	R-HSA-425561	4.113328e-02	1.386
Signaling by AXIN mutants	R-HSA-4839735	4.113328e-02	1.386
Signaling by AMER1 mutants	R-HSA-4839748	4.113328e-02	1.386
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.344032e-02	1.362
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.428758e-02	1.354
Downstream signal transduction	R-HSA-186763	4.476270e-02	1.349
FLT3 signaling in disease	R-HSA-9682385	4.582252e-02	1.339
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.637869e-02	1.334
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.637869e-02	1.334
Apoptosis	R-HSA-109581	4.728634e-02	1.325
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	5.439310e-02	1.264
Signaling by TCF7L2 mutants	R-HSA-5339700	5.439310e-02	1.264
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	5.439310e-02	1.264
Type I hemidesmosome assembly	R-HSA-446107	5.000125e-02	1.301
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.150559e-02	1.288
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.059792e-02	1.296
Ovarian tumor domain proteases	R-HSA-5689896	5.186654e-02	1.285
NGF-stimulated transcription	R-HSA-9031628	5.119591e-02	1.291
Diseases of mitotic cell cycle	R-HSA-9675126	5.123437e-02	1.290
Adrenoceptors	R-HSA-390696	5.000125e-02	1.301
Regulation of PTEN gene transcription	R-HSA-8943724	4.908638e-02	1.309
MTOR signalling	R-HSA-165159	5.178121e-02	1.286
Interleukin-15 signaling	R-HSA-8983432	5.150559e-02	1.288
G0 and Early G1	R-HSA-1538133	5.123437e-02	1.290
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.453911e-02	1.263
MITF-M-dependent gene expression	R-HSA-9856651	5.225957e-02	1.282
MAPK family signaling cascades	R-HSA-5683057	5.510461e-02	1.259
Signaling by ERBB4	R-HSA-1236394	5.516921e-02	1.258
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.667448e-02	1.247
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.716415e-02	1.243
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.716415e-02	1.243
Regulated Necrosis	R-HSA-5218859	5.723742e-02	1.242
Processing of DNA double-strand break ends	R-HSA-5693607	5.761623e-02	1.239
Signaling by SCF-KIT	R-HSA-1433557	5.786784e-02	1.238
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.794374e-02	1.237
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.794374e-02	1.237
NrCAM interactions	R-HSA-447038	5.794374e-02	1.237
Heme signaling	R-HSA-9707616	5.925533e-02	1.227
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.935694e-02	1.227
Chromatin organization	R-HSA-4839726	6.102702e-02	1.214
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.446672e-02	1.191
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.326981e-02	1.199
Chaperone Mediated Autophagy	R-HSA-9613829	7.014783e-02	1.154
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.240721e-02	1.205
Resolution of D-Loop Structures	R-HSA-5693537	6.594358e-02	1.181
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.324395e-02	1.199
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.718144e-02	1.173
GP1b-IX-V activation signalling	R-HSA-430116	6.446672e-02	1.191
Effects of PIP2 hydrolysis	R-HSA-114508	6.594358e-02	1.181
Synaptic adhesion-like molecules	R-HSA-8849932	7.014783e-02	1.154
EPHB-mediated forward signaling	R-HSA-3928662	6.440949e-02	1.191
Selective autophagy	R-HSA-9663891	6.445346e-02	1.191
Membrane Trafficking	R-HSA-199991	6.966278e-02	1.157
Neuronal System	R-HSA-112316	6.622657e-02	1.179
L1CAM interactions	R-HSA-373760	6.238017e-02	1.205
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.141367e-02	1.146
RAF/MAP kinase cascade	R-HSA-5673001	7.268043e-02	1.139
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.446672e-02	1.191
Signaling by ALK	R-HSA-201556	6.548586e-02	1.184
Aggrephagy	R-HSA-9646399	7.307917e-02	1.136
NPAS4 regulates expression of target genes	R-HSA-9768919	7.420039e-02	1.130
RAF activation	R-HSA-5673000	7.420039e-02	1.130
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.446936e-02	1.128
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.446936e-02	1.128
Formation of RNA Pol II elongation complex	R-HSA-112382	7.629963e-02	1.117
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.641796e-02	1.117
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.641796e-02	1.117
Regulation of TP53 Expression	R-HSA-6804754	8.929188e-02	1.049
Regulation of cortical dendrite branching	R-HSA-8985801	8.929188e-02	1.049
Potassium transport channels	R-HSA-1296067	8.929188e-02	1.049
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	7.917374e-02	1.101
MET activates RAP1 and RAC1	R-HSA-8875555	8.087405e-02	1.092
Folding of actin by CCT/TriC	R-HSA-390450	8.087405e-02	1.092
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	8.087405e-02	1.092
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.092197e-02	1.041
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.418659e-02	1.075
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.418659e-02	1.075
G1/S-Specific Transcription	R-HSA-69205	9.253977e-02	1.034
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.361748e-02	1.078
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	8.672276e-02	1.062
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.315872e-02	1.031
Rap1 signalling	R-HSA-392517	8.199420e-02	1.086
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	7.855382e-02	1.105
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.990859e-02	1.097
PKMTs methylate histone lysines	R-HSA-3214841	8.120254e-02	1.090
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.904200e-02	1.102
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.418659e-02	1.075
Cellular Senescence	R-HSA-2559583	8.910507e-02	1.050
Calmodulin induced events	R-HSA-111933	9.253977e-02	1.034
CaM pathway	R-HSA-111997	9.253977e-02	1.034
Tandem pore domain potassium channels	R-HSA-1296346	8.087405e-02	1.092
Cell-extracellular matrix interactions	R-HSA-446353	9.092197e-02	1.041
Kinesins	R-HSA-983189	8.747404e-02	1.058
Trafficking of AMPA receptors	R-HSA-399719	9.461251e-02	1.024
MAPK1/MAPK3 signaling	R-HSA-5684996	9.508442e-02	1.022
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.524597e-02	1.021
Co-stimulation by CD28	R-HSA-389356	9.524597e-02	1.021
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.904609e-02	1.004
Regulation of localization of FOXO transcription factors	R-HSA-9614399	9.912929e-02	1.004
ChREBP activates metabolic gene expression	R-HSA-163765	9.912929e-02	1.004
TCF dependent signaling in response to WNT	R-HSA-201681	1.024172e-01	0.990
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.032590e-01	0.986
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.041343e-01	0.982
Late Phase of HIV Life Cycle	R-HSA-162599	1.058961e-01	0.975
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.168555e-01	0.932
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.168555e-01	0.932
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.168555e-01	0.932
Diseases of Telomere Maintenance	R-HSA-9673013	2.200618e-01	0.657
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.200618e-01	0.657
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.200618e-01	0.657
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.200618e-01	0.657
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	2.200618e-01	0.657
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.200618e-01	0.657
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.200618e-01	0.657
Defective MOGS causes CDG-2b	R-HSA-4793954	2.200618e-01	0.657
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.200618e-01	0.657
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.200618e-01	0.657
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.717754e-01	0.765
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.717754e-01	0.765
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.717754e-01	0.765
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.717754e-01	0.765
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.717754e-01	0.765
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.112125e-01	0.507
Mitochondrial transcription initiation	R-HSA-163282	3.112125e-01	0.507
Interactions of Tat with host cellular proteins	R-HSA-176034	3.112125e-01	0.507
NFG and proNGF binds to p75NTR	R-HSA-205017	3.112125e-01	0.507
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	3.112125e-01	0.507
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.112125e-01	0.507
XAV939 stabilizes AXIN	R-HSA-5545619	3.112125e-01	0.507
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.112125e-01	0.507
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.112125e-01	0.507
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.112125e-01	0.507
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.112125e-01	0.507
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.112125e-01	0.507
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.112125e-01	0.507
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.112125e-01	0.507
MyD88 deficiency (TLR5)	R-HSA-5602680	3.112125e-01	0.507
Intestinal infectious diseases	R-HSA-8942233	3.112125e-01	0.507
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.112125e-01	0.507
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.298329e-01	0.887
RUNX3 regulates WNT signaling	R-HSA-8951430	1.298329e-01	0.887
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.298329e-01	0.887
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.298329e-01	0.887
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.164912e-01	0.665
G2 Phase	R-HSA-68911	2.164912e-01	0.665
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.164912e-01	0.665
Regulation by c-FLIP	R-HSA-3371378	1.585068e-01	0.800
RSK activation	R-HSA-444257	1.585068e-01	0.800
Dimerization of procaspase-8	R-HSA-69416	1.585068e-01	0.800
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.191083e-01	0.924
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.191083e-01	0.924
Phosphorylation of the APC/C	R-HSA-176412	1.067356e-01	0.972
SHC-related events triggered by IGF1R	R-HSA-2428933	1.406635e-01	0.852
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.888876e-01	0.724
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.888876e-01	0.724
Interleukin-21 signaling	R-HSA-9020958	1.888876e-01	0.724
CASP8 activity is inhibited	R-HSA-5218900	1.888876e-01	0.724
ALK mutants bind TKIs	R-HSA-9700645	1.888876e-01	0.724
TRAIL signaling	R-HSA-75158	2.620703e-01	0.582
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.620703e-01	0.582
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.620703e-01	0.582
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.620703e-01	0.582
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.620703e-01	0.582
TWIK related potassium channel (TREK)	R-HSA-1299503	3.917151e-01	0.407
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.917151e-01	0.407
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.917151e-01	0.407
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.917151e-01	0.407
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.917151e-01	0.407
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.917151e-01	0.407
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.237964e-01	0.907
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.636301e-01	0.786
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.205920e-01	0.656
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.420282e-01	0.848
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.420282e-01	0.848
STAT5 Activation	R-HSA-9645135	3.077007e-01	0.512
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.077007e-01	0.512
Signaling by EGFR in Cancer	R-HSA-1643713	1.080224e-01	0.966
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.613433e-01	0.792
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	1.394961e-01	0.855
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.532551e-01	0.596
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.532551e-01	0.596
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.532551e-01	0.596
Activated NTRK3 signals through RAS	R-HSA-9034864	2.532551e-01	0.596
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.212113e-01	0.916
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.212113e-01	0.916
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.130858e-01	0.671
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.816448e-01	0.741
Interleukin receptor SHC signaling	R-HSA-912526	1.562058e-01	0.806
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.562058e-01	0.806
HIV elongation arrest and recovery	R-HSA-167287	1.351840e-01	0.869
Pausing and recovery of HIV elongation	R-HSA-167290	1.351840e-01	0.869
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.175576e-01	0.930
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.300484e-01	0.886
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.300484e-01	0.886
Downstream signaling of activated FGFR3	R-HSA-5654708	1.499082e-01	0.824
Late endosomal microautophagy	R-HSA-9615710	1.499082e-01	0.824
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.737426e-01	0.760
Co-inhibition by CTLA4	R-HSA-389513	2.028289e-01	0.693
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.028289e-01	0.693
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.028289e-01	0.693
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.028289e-01	0.693
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.028289e-01	0.693
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.392076e-01	0.621
Activated NTRK2 signals through RAS	R-HSA-9026519	2.865374e-01	0.543
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.865374e-01	0.543
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.865374e-01	0.543
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.527483e-01	0.453
MET activates PI3K/AKT signaling	R-HSA-8851907	3.527483e-01	0.453
Netrin mediated repulsion signals	R-HSA-418886	3.527483e-01	0.453
TRIF-mediated programmed cell death	R-HSA-2562578	3.527483e-01	0.453
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.527483e-01	0.453
SOS-mediated signalling	R-HSA-112412	3.527483e-01	0.453
Axonal growth stimulation	R-HSA-209563	4.628131e-01	0.335
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.628131e-01	0.335
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.628131e-01	0.335
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.628131e-01	0.335
MET activates PTPN11	R-HSA-8865999	4.628131e-01	0.335
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	4.628131e-01	0.335
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.628131e-01	0.335
Defective CYP7B1 causes SPG5A and CBAS3	R-HSA-5579013	4.628131e-01	0.335
Defective GCLC causes HAGGSD	R-HSA-5578999	4.628131e-01	0.335
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.628131e-01	0.335
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.245690e-01	0.905
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.245690e-01	0.905
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.431919e-01	0.844
Downstream signaling of activated FGFR4	R-HSA-5654716	1.653462e-01	0.782
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.653462e-01	0.782
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.920418e-01	0.717
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.247867e-01	0.648
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.247867e-01	0.648
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.247867e-01	0.648
HIV Transcription Elongation	R-HSA-167169	1.364143e-01	0.865
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.364143e-01	0.865
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.364143e-01	0.865
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.364143e-01	0.865
Downstream signaling of activated FGFR1	R-HSA-5654687	1.569630e-01	0.804
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.660142e-01	0.575
p75NTR recruits signalling complexes	R-HSA-209543	3.201284e-01	0.495
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	3.201284e-01	0.495
Leading Strand Synthesis	R-HSA-69109	3.201284e-01	0.495
Polymerase switching	R-HSA-69091	3.201284e-01	0.495
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.201284e-01	0.495
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.474069e-01	0.607
mRNA 3'-end processing	R-HSA-72187	1.335906e-01	0.874
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.265570e-01	0.898
Recycling pathway of L1	R-HSA-437239	1.527626e-01	0.816
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.306463e-01	0.637
PI3K events in ERBB2 signaling	R-HSA-1963642	2.933275e-01	0.533
FGFR1b ligand binding and activation	R-HSA-190370	3.967264e-01	0.402
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.967264e-01	0.402
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.508031e-01	0.601
Striated Muscle Contraction	R-HSA-390522	2.333299e-01	0.632
Nuclear Receptor transcription pathway	R-HSA-383280	1.235528e-01	0.908
GAB1 signalosome	R-HSA-180292	3.209766e-01	0.494
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.190738e-01	0.924
Downstream signaling of activated FGFR2	R-HSA-5654696	2.703380e-01	0.568
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.703380e-01	0.568
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.924408e-01	0.534
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.181194e-01	0.497
PI-3K cascade:FGFR3	R-HSA-5654710	3.488000e-01	0.457
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.488000e-01	0.457
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.488000e-01	0.457
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.871521e-01	0.412
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	3.871521e-01	0.412
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.871521e-01	0.412
CRMPs in Sema3A signaling	R-HSA-399956	3.871521e-01	0.412
ARMS-mediated activation	R-HSA-170984	4.392699e-01	0.357
Regulated proteolysis of p75NTR	R-HSA-193692	4.392699e-01	0.357
WNT mediated activation of DVL	R-HSA-201688	4.392699e-01	0.357
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	4.392699e-01	0.357
TNFR1-mediated ceramide production	R-HSA-5626978	5.256047e-01	0.279
NADE modulates death signalling	R-HSA-205025	5.256047e-01	0.279
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.256047e-01	0.279
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.256047e-01	0.279
ATP sensitive Potassium channels	R-HSA-1296025	5.256047e-01	0.279
Defective LFNG causes SCDO3	R-HSA-5083630	5.256047e-01	0.279
Signaling by LRP5 mutants	R-HSA-5339717	5.256047e-01	0.279
EGFR downregulation	R-HSA-182971	3.137663e-01	0.503
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.137663e-01	0.503
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.137663e-01	0.503
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.137663e-01	0.503
PI-3K cascade:FGFR4	R-HSA-5654720	3.766466e-01	0.424
RNA Polymerase II Transcription Termination	R-HSA-73856	2.445296e-01	0.612
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.087594e-01	0.510
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.735331e-01	0.761
Transcription of the HIV genome	R-HSA-167172	2.416696e-01	0.617
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	3.353271e-01	0.475
Spry regulation of FGF signaling	R-HSA-1295596	4.201226e-01	0.377
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.201226e-01	0.377
Translesion synthesis by REV1	R-HSA-110312	4.201226e-01	0.377
SHC1 events in EGFR signaling	R-HSA-180336	4.201226e-01	0.377
mRNA Splicing - Major Pathway	R-HSA-72163	1.208875e-01	0.918
IPs transport between nucleus and cytosol	R-HSA-1855170	3.570483e-01	0.447
Lagging Strand Synthesis	R-HSA-69186	4.043772e-01	0.393
SHC-mediated cascade:FGFR3	R-HSA-5654704	4.043772e-01	0.393
Formation of apoptosome	R-HSA-111458	4.801134e-01	0.319
Regulation of the apoptosome activity	R-HSA-9627069	4.801134e-01	0.319
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.801134e-01	0.319
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.801134e-01	0.319
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.908415e-01	0.408
Formation of a pool of free 40S subunits	R-HSA-72689	2.512431e-01	0.600
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.397444e-01	0.469
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.788571e-01	0.422
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	4.524756e-01	0.344
Translesion synthesis by POLI	R-HSA-5656121	4.524756e-01	0.344
snRNP Assembly	R-HSA-191859	3.243255e-01	0.489
Metabolism of non-coding RNA	R-HSA-194441	3.243255e-01	0.489
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.794462e-01	0.554
SHC-mediated cascade:FGFR4	R-HSA-5654719	4.318650e-01	0.365
mRNA Splicing	R-HSA-72172	1.846669e-01	0.734
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.150625e-01	0.382
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.150625e-01	0.382
Formation of the Early Elongation Complex	R-HSA-113418	4.150625e-01	0.382
Translation initiation complex formation	R-HSA-72649	3.661710e-01	0.436
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.167079e-01	0.499
PERK regulates gene expression	R-HSA-381042	4.224614e-01	0.374
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.391255e-01	0.357
PI-3K cascade:FGFR1	R-HSA-5654689	4.589955e-01	0.338
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.840558e-01	0.315
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.840558e-01	0.315
Translesion synthesis by POLK	R-HSA-5655862	4.840558e-01	0.315
Phase 2 - plateau phase	R-HSA-5576893	4.840558e-01	0.315
RHOBTB3 ATPase cycle	R-HSA-9706019	5.190734e-01	0.285
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.008517e-01	0.397
Ribosomal scanning and start codon recognition	R-HSA-72702	4.008517e-01	0.397
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.639547e-01	0.439
HSF1 activation	R-HSA-3371511	4.441271e-01	0.352
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.593587e-01	0.444
Regulation of FZD by ubiquitination	R-HSA-4641263	5.147347e-01	0.288
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.147347e-01	0.288
Deadenylation of mRNA	R-HSA-429947	5.117906e-01	0.291
SHC-mediated cascade:FGFR1	R-HSA-5654688	5.117906e-01	0.291
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.562563e-01	0.341
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.064604e-01	0.295
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.161996e-01	0.287
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.108255e-01	0.292
Transcriptional regulation by RUNX2	R-HSA-8878166	3.903394e-01	0.409
Signaling by FGFR2	R-HSA-5654738	3.039053e-01	0.517
FOXO-mediated transcription	R-HSA-9614085	1.492950e-01	0.826
RUNX2 regulates bone development	R-HSA-8941326	1.713331e-01	0.766
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.150625e-01	0.382
Eukaryotic Translation Initiation	R-HSA-72613	1.978487e-01	0.704
Signaling by FGFR4	R-HSA-5654743	1.087628e-01	0.964
Nucleotide Excision Repair	R-HSA-5696398	3.846002e-01	0.415
Cap-dependent Translation Initiation	R-HSA-72737	1.978487e-01	0.704
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.132998e-01	0.946
Specification of the neural plate border	R-HSA-9834899	1.816448e-01	0.741
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.397902e-01	0.855
HATs acetylate histones	R-HSA-3214847	3.943942e-01	0.404
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.323107e-01	0.274
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.660142e-01	0.575
Extra-nuclear estrogen signaling	R-HSA-9009391	2.363531e-01	0.626
Insulin receptor signalling cascade	R-HSA-74751	1.914294e-01	0.718
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.175576e-01	0.930
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.537490e-01	0.451
Apoptosis induced DNA fragmentation	R-HSA-140342	4.801134e-01	0.319
Signaling by FGFR	R-HSA-190236	3.812553e-01	0.419
Germ layer formation at gastrulation	R-HSA-9754189	1.816448e-01	0.741
Ephrin signaling	R-HSA-3928664	3.209766e-01	0.494
Signaling by FGFR3	R-HSA-5654741	1.297568e-01	0.887
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	2.865374e-01	0.543
MET activates RAS signaling	R-HSA-8851805	3.201284e-01	0.495
Telomere Extension By Telomerase	R-HSA-171319	2.508031e-01	0.601
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.665482e-01	0.436
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.592042e-01	0.445
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.147347e-01	0.288
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.363962e-01	0.865
Signaling by FGFR1	R-HSA-5654736	1.081167e-01	0.966
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.110341e-01	0.676
Prolonged ERK activation events	R-HSA-169893	4.524756e-01	0.344
Extension of Telomeres	R-HSA-180786	2.173186e-01	0.663
IRS-mediated signalling	R-HSA-112399	1.914432e-01	0.718
Killing mechanisms	R-HSA-9664420	4.524756e-01	0.344
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.524756e-01	0.344
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.079896e-01	0.389
Transcriptional regulation of testis differentiation	R-HSA-9690406	4.840558e-01	0.315
ESR-mediated signaling	R-HSA-8939211	3.799795e-01	0.420
G1/S Transition	R-HSA-69206	3.812410e-01	0.419
Interleukin-7 signaling	R-HSA-1266695	1.920418e-01	0.717
DNA Damage Bypass	R-HSA-73893	4.136681e-01	0.383
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.748088e-01	0.323
DNA strand elongation	R-HSA-69190	5.096059e-01	0.293
Estrogen-dependent gene expression	R-HSA-9018519	5.320648e-01	0.274
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.017392e-01	0.695
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.406635e-01	0.852
Signal attenuation	R-HSA-74749	2.205920e-01	0.656
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.924408e-01	0.534
Inwardly rectifying K+ channels	R-HSA-1296065	3.353271e-01	0.475
Cellular response to starvation	R-HSA-9711097	5.177370e-01	0.286
Interleukin-9 signaling	R-HSA-8985947	1.585068e-01	0.800
p75NTR signals via NF-kB	R-HSA-193639	4.201226e-01	0.377
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.856729e-01	0.544
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.888876e-01	0.724
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.562058e-01	0.806
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	1.737426e-01	0.760
IRS-related events triggered by IGF1R	R-HSA-2428928	1.572744e-01	0.803
PI3K Cascade	R-HSA-109704	1.907771e-01	0.719
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.181194e-01	0.497
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.422750e-01	0.466
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.355895e-01	0.361
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.684911e-01	0.571
Mitophagy	R-HSA-5205647	4.006837e-01	0.397
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.591363e-01	0.445
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.840558e-01	0.315
Regulation of necroptotic cell death	R-HSA-5675482	1.175576e-01	0.930
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.717754e-01	0.765
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.888876e-01	0.724
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.888876e-01	0.724
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.132998e-01	0.946
Signalling to RAS	R-HSA-167044	2.247867e-01	0.648
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.488189e-01	0.827
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.933275e-01	0.533
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.154986e-01	0.667
Regulation of CDH11 function	R-HSA-9762292	4.801134e-01	0.319
PI3K/AKT activation	R-HSA-198203	4.801134e-01	0.319
Peptide chain elongation	R-HSA-156902	3.238174e-01	0.490
Regulation of IFNA/IFNB signaling	R-HSA-912694	4.589955e-01	0.338
G2/M Checkpoints	R-HSA-69481	1.763923e-01	0.754
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.962354e-01	0.528
Downregulation of ERBB2 signaling	R-HSA-8863795	1.653462e-01	0.782
Signalling to ERKs	R-HSA-187687	1.569630e-01	0.804
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.392699e-01	0.357
Eukaryotic Translation Elongation	R-HSA-156842	2.077513e-01	0.682
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.636827e-01	0.439
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.318650e-01	0.365
Signaling by Insulin receptor	R-HSA-74752	3.911363e-01	0.408
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.406635e-01	0.852
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.077007e-01	0.512
Interactions of Rev with host cellular proteins	R-HSA-177243	1.364143e-01	0.865
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	3.201284e-01	0.495
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.967264e-01	0.402
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.537490e-01	0.451
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	2.941844e-01	0.531
cGMP effects	R-HSA-418457	3.871521e-01	0.412
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.392699e-01	0.357
Regulation of gap junction activity	R-HSA-191650	5.256047e-01	0.279
Negative regulation of MET activity	R-HSA-6807004	3.766466e-01	0.424
DARPP-32 events	R-HSA-180024	4.391255e-01	0.357
Cyclin E associated events during G1/S transition	R-HSA-69202	3.784545e-01	0.422
TRAF6 mediated NF-kB activation	R-HSA-933542	5.117906e-01	0.291
Meiosis	R-HSA-1500620	4.870444e-01	0.312
Signaling by Hippo	R-HSA-2028269	1.420282e-01	0.848
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.376096e-01	0.624
DNA Double Strand Break Response	R-HSA-5693606	2.286559e-01	0.641
S Phase	R-HSA-69242	1.411869e-01	0.850
G1/S DNA Damage Checkpoints	R-HSA-69615	3.891857e-01	0.410
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.326085e-01	0.877
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.509497e-01	0.600
Repression of WNT target genes	R-HSA-4641265	1.406635e-01	0.852
Nuclear import of Rev protein	R-HSA-180746	2.516285e-01	0.599
NRIF signals cell death from the nucleus	R-HSA-205043	3.871521e-01	0.412
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	4.201226e-01	0.377
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	4.201226e-01	0.377
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.080224e-01	0.966
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	2.392076e-01	0.621
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	2.205920e-01	0.656
RNA Polymerase II Transcription	R-HSA-73857	2.464939e-01	0.608
Gene expression (Transcription)	R-HSA-74160	3.338462e-01	0.476
Host Interactions of HIV factors	R-HSA-162909	3.582398e-01	0.446
EPH-Ephrin signaling	R-HSA-2682334	2.077513e-01	0.682
Generic Transcription Pathway	R-HSA-212436	3.491034e-01	0.457
Signaling by WNT	R-HSA-195721	3.087962e-01	0.510
Inositol transporters	R-HSA-429593	2.164912e-01	0.665
Calcineurin activates NFAT	R-HSA-2025928	1.888876e-01	0.724
Transcription from mitochondrial promoters	R-HSA-75944	3.917151e-01	0.407
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.237964e-01	0.907
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.527483e-01	0.453
Ca2+ activated K+ channels	R-HSA-1296052	3.527483e-01	0.453
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.862702e-01	0.730
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	3.967264e-01	0.402
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	3.967264e-01	0.402
Cellular response to mitochondrial stress	R-HSA-9840373	4.392699e-01	0.357
MAP2K and MAPK activation	R-HSA-5674135	2.681488e-01	0.572
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.159326e-01	0.666
Josephin domain DUBs	R-HSA-5689877	4.801134e-01	0.319
Arachidonate production from DAG	R-HSA-426048	4.801134e-01	0.319
Signaling by MET	R-HSA-6806834	3.039053e-01	0.517
Formation of the posterior neural plate	R-HSA-9832991	5.190734e-01	0.285
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.710144e-01	0.327
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.603999e-01	0.337
Signaling by Nuclear Receptors	R-HSA-9006931	4.961017e-01	0.304
Signaling by VEGF	R-HSA-194138	2.220501e-01	0.654
Cilium Assembly	R-HSA-5617833	2.376836e-01	0.624
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.255452e-01	0.647
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.318264e-01	0.479
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.412114e-01	0.850
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.255452e-01	0.647
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.548494e-01	0.594
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.535474e-01	0.596
Signaling by FGFR in disease	R-HSA-1226099	1.491903e-01	0.826
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.427047e-01	0.354
DNA Repair	R-HSA-73894	1.423674e-01	0.847
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.412114e-01	0.850
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.412114e-01	0.850
mTORC1-mediated signalling	R-HSA-166208	1.394961e-01	0.855
Platelet calcium homeostasis	R-HSA-418360	1.499082e-01	0.824
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.201284e-01	0.495
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.537490e-01	0.451
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.548494e-01	0.594
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.466384e-01	0.834
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.466384e-01	0.834
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.466384e-01	0.834
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.466384e-01	0.834
Signaling by FGFR3 in disease	R-HSA-5655332	3.908415e-01	0.408
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.391255e-01	0.357
Organelle biogenesis and maintenance	R-HSA-1852241	3.001742e-01	0.523
Signaling by NOTCH1	R-HSA-1980143	1.077076e-01	0.968
HIV Infection	R-HSA-162906	1.888733e-01	0.724
Deubiquitination	R-HSA-5688426	1.776440e-01	0.750
Response of endothelial cells to shear stress	R-HSA-9860931	4.603999e-01	0.337
Lipophagy	R-HSA-9613354	1.888876e-01	0.724
Formation of intermediate mesoderm	R-HSA-9761174	2.205920e-01	0.656
Mitochondrial calcium ion transport	R-HSA-8949215	1.236723e-01	0.908
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.532551e-01	0.596
Signaling by Erythropoietin	R-HSA-9006335	1.499082e-01	0.824
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.865374e-01	0.543
FasL/ CD95L signaling	R-HSA-75157	4.628131e-01	0.335
Downregulation of ERBB4 signaling	R-HSA-1253288	3.967264e-01	0.402
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.177024e-01	0.662
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.256047e-01	0.279
Oxidative Stress Induced Senescence	R-HSA-2559580	1.750329e-01	0.757
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.147347e-01	0.288
Nuclear RNA decay	R-HSA-9930044	5.323107e-01	0.274
HIV Life Cycle	R-HSA-162587	1.101631e-01	0.958
G-protein mediated events	R-HSA-112040	3.323274e-01	0.478
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.422750e-01	0.466
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.430323e-01	0.614
Evasion by RSV of host interferon responses	R-HSA-9833109	4.864663e-01	0.313
Activation of BH3-only proteins	R-HSA-114452	1.653462e-01	0.782
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.551609e-01	0.450
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.554575e-01	0.593
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.585068e-01	0.800
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.509497e-01	0.600
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.803634e-01	0.744
Cellular responses to stress	R-HSA-2262752	3.083434e-01	0.511
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.972496e-01	0.527
Opioid Signalling	R-HSA-111885	3.593587e-01	0.444
Protein methylation	R-HSA-8876725	2.130858e-01	0.671
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.816448e-01	0.741
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.660142e-01	0.575
Toll-like Receptor Cascades	R-HSA-168898	3.797033e-01	0.421
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	1.920418e-01	0.717
Cellular responses to stimuli	R-HSA-8953897	4.400248e-01	0.357
Regulation of TP53 Degradation	R-HSA-6804757	2.894009e-01	0.539
Nuclear signaling by ERBB4	R-HSA-1251985	2.341198e-01	0.631
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.289484e-01	0.890
Manipulation of host energy metabolism	R-HSA-9636667	3.112125e-01	0.507
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.112125e-01	0.507
Phase 3 - rapid repolarisation	R-HSA-5576890	1.298329e-01	0.887
Co-stimulation by ICOS	R-HSA-9927354	1.585068e-01	0.800
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.888876e-01	0.724
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	3.917151e-01	0.407
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.917151e-01	0.407
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.636301e-01	0.786
Regulation of KIT signaling	R-HSA-1433559	1.878317e-01	0.726
Regulation of MECP2 expression and activity	R-HSA-9022692	1.175576e-01	0.930
Negative regulation of FLT3	R-HSA-9706369	2.392076e-01	0.621
Phase 4 - resting membrane potential	R-HSA-5576886	2.392076e-01	0.621
Regulation of PTEN localization	R-HSA-8948747	3.527483e-01	0.453
Activation of BMF and translocation to mitochondria	R-HSA-139910	4.628131e-01	0.335
Metalloprotease DUBs	R-HSA-5689901	2.110341e-01	0.676
Signaling by PDGFR in disease	R-HSA-9671555	2.474069e-01	0.607
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.967264e-01	0.402
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.967264e-01	0.402
MAP kinase activation	R-HSA-450294	1.572744e-01	0.803
Electric Transmission Across Gap Junctions	R-HSA-112303	5.256047e-01	0.279
Transmission across Electrical Synapses	R-HSA-112307	5.256047e-01	0.279
EGFR Transactivation by Gastrin	R-HSA-2179392	4.801134e-01	0.319
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.524756e-01	0.344
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.680330e-01	0.434
Smooth Muscle Contraction	R-HSA-445355	3.489388e-01	0.457
Ionotropic activity of kainate receptors	R-HSA-451306	5.190734e-01	0.285
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	5.190734e-01	0.285
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.856671e-01	0.314
Budding and maturation of HIV virion	R-HSA-162588	4.864663e-01	0.313
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.382944e-01	0.358
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.078813e-01	0.294
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.255578e-01	0.279
Platelet activation, signaling and aggregation	R-HSA-76002	1.592483e-01	0.798
MyD88-independent TLR4 cascade	R-HSA-166166	1.912197e-01	0.718
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.912197e-01	0.718
Ca-dependent events	R-HSA-111996	1.752251e-01	0.756
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.682933e-01	0.774
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.655048e-01	0.332
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.236723e-01	0.908
Signaling by PTK6	R-HSA-8848021	5.210040e-01	0.283
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.210040e-01	0.283
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.255578e-01	0.279
PLC beta mediated events	R-HSA-112043	2.445296e-01	0.612
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.486943e-01	0.828
Signaling by FGFR4 in disease	R-HSA-5655291	1.878317e-01	0.726
Pyroptosis	R-HSA-5620971	1.351840e-01	0.869
Interleukin-17 signaling	R-HSA-448424	2.684911e-01	0.571
Regulation of NF-kappa B signaling	R-HSA-9758274	4.524756e-01	0.344
Platelet degranulation	R-HSA-114608	4.981318e-01	0.303
PECAM1 interactions	R-HSA-210990	2.532551e-01	0.596
Activated NTRK2 signals through FYN	R-HSA-9032500	3.967264e-01	0.402
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.583695e-01	0.800
Receptor Mediated Mitophagy	R-HSA-8934903	4.801134e-01	0.319
Selenocysteine synthesis	R-HSA-2408557	5.271146e-01	0.278
Signaling by KIT in disease	R-HSA-9669938	1.394961e-01	0.855
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.793392e-01	0.746
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.772798e-01	0.557
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.981895e-01	0.703
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.191989e-01	0.285
Muscarinic acetylcholine receptors	R-HSA-390648	2.164912e-01	0.665
G-protein beta:gamma signalling	R-HSA-397795	3.570483e-01	0.447
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.788571e-01	0.422
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.581177e-01	0.446
Cytokine Signaling in Immune system	R-HSA-1280215	2.810244e-01	0.551
Growth hormone receptor signaling	R-HSA-982772	4.856671e-01	0.314
Signaling by Interleukins	R-HSA-449147	1.737052e-01	0.760
Glycolysis	R-HSA-70171	2.258081e-01	0.646
Golgi-to-ER retrograde transport	R-HSA-8856688	4.744551e-01	0.324
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.466384e-01	0.834
Sensory processing of sound	R-HSA-9659379	2.009725e-01	0.697
Transcriptional Regulation by VENTX	R-HSA-8853884	3.880032e-01	0.411
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.333822e-01	0.875
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.537490e-01	0.451
ISG15 antiviral mechanism	R-HSA-1169408	1.589205e-01	0.799
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.524756e-01	0.344
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.154986e-01	0.667
Formation of the nephric duct	R-HSA-9830364	1.920418e-01	0.717
Signaling by Leptin	R-HSA-2586552	4.801134e-01	0.319
Interleukin-2 signaling	R-HSA-9020558	5.190734e-01	0.285
Amine ligand-binding receptors	R-HSA-375280	3.215159e-01	0.493
GPVI-mediated activation cascade	R-HSA-114604	4.441271e-01	0.352
Tie2 Signaling	R-HSA-210993	3.209766e-01	0.494
TBC/RABGAPs	R-HSA-8854214	3.034770e-01	0.518
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.790571e-01	0.747
Interleukin-6 signaling	R-HSA-1059683	3.537490e-01	0.451
Signaling by TGFBR3	R-HSA-9839373	5.064604e-01	0.295
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.303737e-01	0.366
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.164912e-01	0.665
DSCAM interactions	R-HSA-376172	3.917151e-01	0.407
Synthesis of PI	R-HSA-1483226	2.532551e-01	0.596
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.175576e-01	0.930
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.865374e-01	0.543
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.628131e-01	0.335
Maturation of nucleoprotein	R-HSA-9683610	3.537490e-01	0.451
Regulation of gene expression in beta cells	R-HSA-210745	2.714272e-01	0.566
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.392699e-01	0.357
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.256047e-01	0.279
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.380003e-01	0.623
Signaling by PDGF	R-HSA-186797	5.042020e-01	0.297
PTEN Regulation	R-HSA-6807070	4.745960e-01	0.324
Signaling by TGFB family members	R-HSA-9006936	3.718230e-01	0.430
MITF-M-regulated melanocyte development	R-HSA-9730414	1.125195e-01	0.949
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.585068e-01	0.800
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.537490e-01	0.451
Glucose metabolism	R-HSA-70326	4.617494e-01	0.336
Zygotic genome activation (ZGA)	R-HSA-9819196	2.247867e-01	0.648
Maturation of nucleoprotein	R-HSA-9694631	3.488000e-01	0.457
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.801134e-01	0.319
Suppression of apoptosis	R-HSA-9635465	5.190734e-01	0.285
Stimuli-sensing channels	R-HSA-2672351	5.256067e-01	0.279
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.355895e-01	0.361
Syndecan interactions	R-HSA-3000170	2.941844e-01	0.531
Formation of the anterior neural plate	R-HSA-9823739	4.201226e-01	0.377
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.164912e-01	0.665
MECP2 regulates transcription factors	R-HSA-9022707	3.527483e-01	0.453
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.628131e-01	0.335
Sodium/Proton exchangers	R-HSA-425986	3.967264e-01	0.402
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.154986e-01	0.667
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.256047e-01	0.279
Dopamine receptors	R-HSA-390651	5.256047e-01	0.279
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.772798e-01	0.557
Maturation of spike protein	R-HSA-9683686	4.801134e-01	0.319
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.801134e-01	0.319
Bicarbonate transporters	R-HSA-425381	5.190734e-01	0.285
Inositol phosphate metabolism	R-HSA-1483249	4.738456e-01	0.324
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.748088e-01	0.323
Metal ion SLC transporters	R-HSA-425410	2.653053e-01	0.576
Interleukin-12 family signaling	R-HSA-447115	5.306023e-01	0.275
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.620703e-01	0.582
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.620703e-01	0.582
Uptake and function of diphtheria toxin	R-HSA-5336415	3.527483e-01	0.453
OAS antiviral response	R-HSA-8983711	3.201284e-01	0.495
Respiratory syncytial virus genome replication	R-HSA-9834752	4.392699e-01	0.357
Interleukin-38 signaling	R-HSA-9007892	5.256047e-01	0.279
Unfolded Protein Response (UPR)	R-HSA-381119	4.745960e-01	0.324
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.022306e-01	0.520
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.078813e-01	0.294
XBP1(S) activates chaperone genes	R-HSA-381038	5.161996e-01	0.287
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.247867e-01	0.648
Interleukin-12 signaling	R-HSA-9020591	4.717362e-01	0.326
Interleukin-37 signaling	R-HSA-9008059	2.924408e-01	0.534
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	1.394961e-01	0.855
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	1.613433e-01	0.792
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.326496e-01	0.274
ATP-dependent chromatin remodelers	R-HSA-9932444	5.372890e-01	0.270
SWI/SNF chromatin remodelers	R-HSA-9932451	5.372890e-01	0.270
PI-3K cascade:FGFR2	R-HSA-5654695	5.372890e-01	0.270
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	5.372890e-01	0.270
Activation of G protein gated Potassium channels	R-HSA-1296041	5.372890e-01	0.270
G protein gated Potassium channels	R-HSA-1296059	5.372890e-01	0.270
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.372890e-01	0.270
TGFBR3 expression	R-HSA-9839394	5.372890e-01	0.270
Neutrophil degranulation	R-HSA-6798695	5.389396e-01	0.268
TNF signaling	R-HSA-75893	5.406985e-01	0.267
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.424908e-01	0.266
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.444091e-01	0.264
Apoptotic factor-mediated response	R-HSA-111471	5.444091e-01	0.264
Mismatch Repair	R-HSA-5358508	5.444091e-01	0.264
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.475277e-01	0.262
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.488508e-01	0.261
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.488508e-01	0.261
TCR signaling	R-HSA-202403	5.510949e-01	0.259
Developmental Biology	R-HSA-1266738	5.522643e-01	0.258
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.560320e-01	0.255
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.560320e-01	0.255
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.560320e-01	0.255
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.560320e-01	0.255
NF-kB is activated and signals survival	R-HSA-209560	5.560320e-01	0.255
Eukaryotic Translation Termination	R-HSA-72764	5.560752e-01	0.255
Nuclear Envelope Breakdown	R-HSA-2980766	5.580449e-01	0.253
Mitochondrial biogenesis	R-HSA-1592230	5.611258e-01	0.251
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.620969e-01	0.250
Myogenesis	R-HSA-525793	5.620969e-01	0.250
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.620969e-01	0.250
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.620969e-01	0.250
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.687489e-01	0.245
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.695102e-01	0.244
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.695102e-01	0.244
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.722549e-01	0.242
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.729981e-01	0.242
Translesion Synthesis by POLH	R-HSA-110320	5.729981e-01	0.242
The NLRP3 inflammasome	R-HSA-844456	5.729981e-01	0.242
Early SARS-CoV-2 Infection Events	R-HSA-9772572	5.751064e-01	0.240
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.761029e-01	0.239
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.761029e-01	0.239
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.762145e-01	0.239
Dual Incision in GG-NER	R-HSA-5696400	5.762145e-01	0.239
NOD1/2 Signaling Pathway	R-HSA-168638	5.762145e-01	0.239
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.794121e-01	0.237
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.810598e-01	0.236
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.810598e-01	0.236
IRS activation	R-HSA-74713	5.810598e-01	0.236
Defective CYP17A1 causes AH5	R-HSA-5579028	5.810598e-01	0.236
NOSIP mediated eNOS trafficking	R-HSA-203754	5.810598e-01	0.236
Defective F9 activation	R-HSA-9673221	5.810598e-01	0.236
FLT3 signaling by CBL mutants	R-HSA-9706377	5.810598e-01	0.236
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.810598e-01	0.236
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.810598e-01	0.236
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.810598e-01	0.236
PTK6 Down-Regulation	R-HSA-8849472	5.810598e-01	0.236
Activation of AKT2	R-HSA-165158	5.810598e-01	0.236
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.810598e-01	0.236
Activation of C3 and C5	R-HSA-174577	5.810598e-01	0.236
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.810598e-01	0.236
Telomere Maintenance	R-HSA-157579	5.827832e-01	0.234
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.861598e-01	0.232
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.861598e-01	0.232
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.861598e-01	0.232
RUNX3 regulates p14-ARF	R-HSA-8951936	5.909248e-01	0.228
IRAK1 recruits IKK complex	R-HSA-937039	5.909248e-01	0.228
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.909248e-01	0.228
GRB2 events in EGFR signaling	R-HSA-179812	5.909248e-01	0.228
Scavenging by Class F Receptors	R-HSA-3000484	5.909248e-01	0.228
Regulation of IFNG signaling	R-HSA-877312	5.909248e-01	0.228
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.909248e-01	0.228
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.909248e-01	0.228
Regulation of beta-cell development	R-HSA-186712	5.918600e-01	0.228
Phospholipid metabolism	R-HSA-1483257	5.951813e-01	0.225
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.973292e-01	0.224
Meiotic recombination	R-HSA-912446	5.987716e-01	0.223
IRE1alpha activates chaperones	R-HSA-381070	6.002404e-01	0.222
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.004417e-01	0.222
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.004417e-01	0.222
Formation of definitive endoderm	R-HSA-9823730	6.004417e-01	0.222
Cellular responses to mechanical stimuli	R-HSA-9855142	6.005482e-01	0.221
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.072044e-01	0.217
GABA receptor activation	R-HSA-977443	6.082851e-01	0.216
Chromosome Maintenance	R-HSA-73886	6.086301e-01	0.216
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.094338e-01	0.215
Clathrin-mediated endocytosis	R-HSA-8856828	6.199584e-01	0.208
Transmission across Chemical Synapses	R-HSA-112315	6.203064e-01	0.207
Frs2-mediated activation	R-HSA-170968	6.237298e-01	0.205
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.237298e-01	0.205
FGFR1c ligand binding and activation	R-HSA-190373	6.237298e-01	0.205
Chylomicron remodeling	R-HSA-8963901	6.237298e-01	0.205
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.237298e-01	0.205
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.237298e-01	0.205
Processing of SMDT1	R-HSA-8949664	6.237298e-01	0.205
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.243635e-01	0.205
RMTs methylate histone arginines	R-HSA-3214858	6.257070e-01	0.204
G1 Phase	R-HSA-69236	6.257070e-01	0.204
Cyclin D associated events in G1	R-HSA-69231	6.257070e-01	0.204
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.266977e-01	0.203
Basigin interactions	R-HSA-210991	6.266977e-01	0.203
ERK/MAPK targets	R-HSA-198753	6.266977e-01	0.203
Interleukin-1 family signaling	R-HSA-446652	6.268889e-01	0.203
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.300352e-01	0.201
PDE3B signalling	R-HSA-165160	6.300352e-01	0.201
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.300352e-01	0.201
PKB-mediated events	R-HSA-109703	6.300352e-01	0.201
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.300352e-01	0.201
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.300352e-01	0.201
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.300352e-01	0.201
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.300352e-01	0.201
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.300352e-01	0.201
Signaling by RNF43 mutants	R-HSA-5340588	6.300352e-01	0.201
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.300352e-01	0.201
CLEC7A/inflammasome pathway	R-HSA-5660668	6.300352e-01	0.201
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.300352e-01	0.201
NGF-independant TRKA activation	R-HSA-187024	6.300352e-01	0.201
Pentose phosphate pathway disease	R-HSA-6791465	6.300352e-01	0.201
CDC6 association with the ORC:origin complex	R-HSA-68689	6.300352e-01	0.201
Ceramide signalling	R-HSA-193681	6.300352e-01	0.201
Phosphorylation of Emi1	R-HSA-176417	6.300352e-01	0.201
Formation of the Editosome	R-HSA-75094	6.300352e-01	0.201
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.300352e-01	0.201
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.300352e-01	0.201
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.300352e-01	0.201
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.300352e-01	0.201
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.300352e-01	0.201
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.300352e-01	0.201
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.300352e-01	0.201
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	6.318843e-01	0.199
Termination of translesion DNA synthesis	R-HSA-5656169	6.318843e-01	0.199
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	6.318843e-01	0.199
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.320035e-01	0.199
Meiotic synapsis	R-HSA-1221632	6.331001e-01	0.199
Vesicle-mediated transport	R-HSA-5653656	6.338836e-01	0.198
Interleukin-1 signaling	R-HSA-9020702	6.340320e-01	0.198
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.377194e-01	0.195
NCAM signaling for neurite out-growth	R-HSA-375165	6.400787e-01	0.194
Interferon Signaling	R-HSA-913531	6.431106e-01	0.192
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.466937e-01	0.189
Regulation of mitotic cell cycle	R-HSA-453276	6.466937e-01	0.189
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.517402e-01	0.186
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.517402e-01	0.186
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.517402e-01	0.186
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.517402e-01	0.186
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.523198e-01	0.186
Activation of the pre-replicative complex	R-HSA-68962	6.534858e-01	0.185
DAP12 signaling	R-HSA-2424491	6.534858e-01	0.185
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.544582e-01	0.184
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.544582e-01	0.184
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.544582e-01	0.184
Prolactin receptor signaling	R-HSA-1170546	6.544582e-01	0.184
Signal regulatory protein family interactions	R-HSA-391160	6.544582e-01	0.184
P2Y receptors	R-HSA-417957	6.544582e-01	0.184
Zinc transporters	R-HSA-435354	6.544582e-01	0.184
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.544582e-01	0.184
Influenza Infection	R-HSA-168255	6.551927e-01	0.184
MET promotes cell motility	R-HSA-8875878	6.569466e-01	0.182
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.569466e-01	0.182
Viral mRNA Translation	R-HSA-192823	6.584152e-01	0.182
Regulation of TNFR1 signaling	R-HSA-5357905	6.611551e-01	0.180
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.647476e-01	0.177
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.656951e-01	0.177
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.703651e-01	0.174
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.732878e-01	0.172
Erythropoietin activates STAT5	R-HSA-9027283	6.732878e-01	0.172
Autointegration results in viral DNA circles	R-HSA-177539	6.732878e-01	0.172
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.732878e-01	0.172
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.732878e-01	0.172
Hydrolysis of LPE	R-HSA-1483152	6.732878e-01	0.172
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.732878e-01	0.172
Neurofascin interactions	R-HSA-447043	6.732878e-01	0.172
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.732878e-01	0.172
Signaling by LTK in cancer	R-HSA-9842640	6.732878e-01	0.172
HDL clearance	R-HSA-8964011	6.732878e-01	0.172
Leukotriene receptors	R-HSA-391906	6.732878e-01	0.172
Nef and signal transduction	R-HSA-164944	6.732878e-01	0.172
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.755570e-01	0.170
FGFR2 alternative splicing	R-HSA-6803529	6.755570e-01	0.170
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.755570e-01	0.170
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.755570e-01	0.170
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.755570e-01	0.170
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	6.755570e-01	0.170
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.755570e-01	0.170
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.755570e-01	0.170
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	6.755570e-01	0.170
Ub-specific processing proteases	R-HSA-5689880	6.771346e-01	0.169
Signaling by NOTCH	R-HSA-157118	6.830686e-01	0.166
Processive synthesis on the lagging strand	R-HSA-69183	6.831472e-01	0.165
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.831472e-01	0.165
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.831472e-01	0.165
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.831472e-01	0.165
Erythropoietin activates RAS	R-HSA-9027284	6.831472e-01	0.165
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.831472e-01	0.165
Telomere C-strand synthesis initiation	R-HSA-174430	6.831472e-01	0.165
p38MAPK events	R-HSA-171007	6.831472e-01	0.165
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.831472e-01	0.165
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.831472e-01	0.165
Downstream TCR signaling	R-HSA-202424	6.843211e-01	0.165
Base Excision Repair	R-HSA-73884	6.843211e-01	0.165
Cell-Cell communication	R-HSA-1500931	6.879061e-01	0.162
Transcriptional regulation by RUNX3	R-HSA-8878159	6.888381e-01	0.162
Attenuation phase	R-HSA-3371568	6.933835e-01	0.159
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.933835e-01	0.159
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.933835e-01	0.159
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.933835e-01	0.159
Glycogen metabolism	R-HSA-8982491	6.933835e-01	0.159
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.940791e-01	0.159
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.959292e-01	0.157
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.981480e-01	0.156
Interleukin-20 family signaling	R-HSA-8854691	6.981480e-01	0.156
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.098535e-01	0.149
Activation of SMO	R-HSA-5635838	7.098535e-01	0.149
Attachment and Entry	R-HSA-9678110	7.098535e-01	0.149
Differentiation of T cells	R-HSA-9945266	7.098535e-01	0.149
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.098535e-01	0.149
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.098535e-01	0.149
Serotonin and melatonin biosynthesis	R-HSA-209931	7.098535e-01	0.149
Integration of energy metabolism	R-HSA-163685	7.100145e-01	0.149
Maturation of spike protein	R-HSA-9694548	7.105747e-01	0.148
Dual incision in TC-NER	R-HSA-6782135	7.111164e-01	0.148
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.114860e-01	0.148
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.114860e-01	0.148
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.114860e-01	0.148
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.114860e-01	0.148
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.114860e-01	0.148
Recycling of eIF2:GDP	R-HSA-72731	7.114860e-01	0.148
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.114860e-01	0.148
Cohesin Loading onto Chromatin	R-HSA-2470946	7.114860e-01	0.148
mRNA Editing: C to U Conversion	R-HSA-72200	7.114860e-01	0.148
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.114860e-01	0.148
VLDL clearance	R-HSA-8964046	7.114860e-01	0.148
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.114860e-01	0.148
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.114860e-01	0.148
Activation of TRKA receptors	R-HSA-187015	7.114860e-01	0.148
Cation-coupled Chloride cotransporters	R-HSA-426117	7.114860e-01	0.148
CHL1 interactions	R-HSA-447041	7.114860e-01	0.148
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.114860e-01	0.148
Maturation of replicase proteins	R-HSA-9694301	7.114860e-01	0.148
Kidney development	R-HSA-9830369	7.127820e-01	0.147
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.130571e-01	0.147
Cardiogenesis	R-HSA-9733709	7.130571e-01	0.147
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.152802e-01	0.146
Complex III assembly	R-HSA-9865881	7.195235e-01	0.143
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	7.195235e-01	0.143
Interleukin-6 family signaling	R-HSA-6783589	7.195235e-01	0.143
SARS-CoV-2-host interactions	R-HSA-9705683	7.201574e-01	0.143
Deadenylation-dependent mRNA decay	R-HSA-429914	7.253000e-01	0.139
Signaling by FGFR2 in disease	R-HSA-5655253	7.254501e-01	0.139
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.260897e-01	0.139
Negative regulation of MAPK pathway	R-HSA-5675221	7.270757e-01	0.138
Translation of Structural Proteins	R-HSA-9683701	7.270757e-01	0.138
Translation of Structural Proteins	R-HSA-9694635	7.275023e-01	0.138
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.311570e-01	0.136
Miscellaneous transport and binding events	R-HSA-5223345	7.311570e-01	0.136
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.346486e-01	0.134
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.346486e-01	0.134
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.346486e-01	0.134
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.346486e-01	0.134
Disorders of Developmental Biology	R-HSA-9675151	7.346486e-01	0.134
Synthesis of PG	R-HSA-1483148	7.346486e-01	0.134
Adipogenesis	R-HSA-9843745	7.349499e-01	0.134
SARS-CoV-2 Infection	R-HSA-9694516	7.377909e-01	0.132
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.389752e-01	0.131
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.389988e-01	0.131
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.389988e-01	0.131
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.397022e-01	0.131
GABA B receptor activation	R-HSA-977444	7.428871e-01	0.129
Activation of GABAB receptors	R-HSA-991365	7.428871e-01	0.129
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.428871e-01	0.129
ROBO receptors bind AKAP5	R-HSA-9010642	7.452201e-01	0.128
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.452201e-01	0.128
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.452201e-01	0.128
MET receptor recycling	R-HSA-8875656	7.452201e-01	0.128
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.452201e-01	0.128
Formation of annular gap junctions	R-HSA-196025	7.452201e-01	0.128
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.452201e-01	0.128
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.452201e-01	0.128
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.452201e-01	0.128
TGFBR3 PTM regulation	R-HSA-9839383	7.452201e-01	0.128
Alpha-defensins	R-HSA-1462054	7.452201e-01	0.128
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.483860e-01	0.126
Signaling by NOTCH2	R-HSA-1980145	7.483860e-01	0.126
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.483860e-01	0.126
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.483860e-01	0.126
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.514369e-01	0.124
Chaperonin-mediated protein folding	R-HSA-390466	7.521469e-01	0.124
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.576141e-01	0.121
Uptake and function of anthrax toxins	R-HSA-5210891	7.576141e-01	0.121
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.576141e-01	0.121
Specification of primordial germ cells	R-HSA-9827857	7.576141e-01	0.121
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.587099e-01	0.120
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.629283e-01	0.118
Oncogene Induced Senescence	R-HSA-2559585	7.647560e-01	0.116
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.649395e-01	0.116
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.649395e-01	0.116
tRNA processing in the nucleus	R-HSA-6784531	7.649395e-01	0.116
SARS-CoV-1 Infection	R-HSA-9678108	7.654976e-01	0.116
Transcriptional regulation by RUNX1	R-HSA-8878171	7.668247e-01	0.115
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.677200e-01	0.115
Amino acids regulate mTORC1	R-HSA-9639288	7.677200e-01	0.115
Interferon gamma signaling	R-HSA-877300	7.685542e-01	0.114
COPI-mediated anterograde transport	R-HSA-6807878	7.737526e-01	0.111
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.750116e-01	0.111
Gap junction degradation	R-HSA-190873	7.750116e-01	0.111
p75NTR regulates axonogenesis	R-HSA-193697	7.750116e-01	0.111
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.750116e-01	0.111
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.750116e-01	0.111
Unwinding of DNA	R-HSA-176974	7.750116e-01	0.111
Interleukin-1 processing	R-HSA-448706	7.750116e-01	0.111
mRNA Editing	R-HSA-75072	7.750116e-01	0.111
Regulation of CDH11 gene transcription	R-HSA-9762293	7.750116e-01	0.111
Transcriptional regulation by small RNAs	R-HSA-5578749	7.750893e-01	0.111
Mitotic Prophase	R-HSA-68875	7.762984e-01	0.110
EPHA-mediated growth cone collapse	R-HSA-3928663	7.765785e-01	0.110
Packaging Of Telomere Ends	R-HSA-171306	7.765785e-01	0.110
Insulin processing	R-HSA-264876	7.765785e-01	0.110
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.771849e-01	0.109
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.788389e-01	0.109
FGFR1 ligand binding and activation	R-HSA-190242	7.788389e-01	0.109
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.788389e-01	0.109
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.788389e-01	0.109
Nucleotide-like (purinergic) receptors	R-HSA-418038	7.788389e-01	0.109
Nephron development	R-HSA-9831926	7.788389e-01	0.109
Platelet sensitization by LDL	R-HSA-432142	7.788389e-01	0.109
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.788389e-01	0.109
Developmental Cell Lineages	R-HSA-9734767	7.834886e-01	0.106
Epigenetic regulation of gene expression	R-HSA-212165	7.835082e-01	0.106
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.862383e-01	0.104
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.862383e-01	0.104
Ca2+ pathway	R-HSA-4086398	7.862836e-01	0.104
Ion transport by P-type ATPases	R-HSA-936837	7.889517e-01	0.103
Platelet homeostasis	R-HSA-418346	7.928698e-01	0.101
HDACs deacetylate histones	R-HSA-3214815	7.930889e-01	0.101
Signaling by NOTCH3	R-HSA-9012852	7.930889e-01	0.101
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.933443e-01	0.101
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.933443e-01	0.101
Inflammasomes	R-HSA-622312	7.933443e-01	0.101
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.937012e-01	0.100
TRAF6 mediated IRF7 activation	R-HSA-933541	7.949847e-01	0.100
Cleavage of the damaged purine	R-HSA-110331	7.949847e-01	0.100
Regulation of signaling by CBL	R-HSA-912631	7.984160e-01	0.098
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.984160e-01	0.098
E2F mediated regulation of DNA replication	R-HSA-113510	7.984160e-01	0.098
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.984160e-01	0.098
Condensation of Prophase Chromosomes	R-HSA-2299718	7.993591e-01	0.097
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.993591e-01	0.097
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.013212e-01	0.096
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.013212e-01	0.096
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.013212e-01	0.096
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.013212e-01	0.096
2-LTR circle formation	R-HSA-164843	8.013212e-01	0.096
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.013212e-01	0.096
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.013212e-01	0.096
Interleukin-27 signaling	R-HSA-9020956	8.013212e-01	0.096
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.013212e-01	0.096
Sperm Motility And Taxes	R-HSA-1300642	8.013212e-01	0.096
Defective factor IX causes hemophilia B	R-HSA-9668250	8.013212e-01	0.096
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.013212e-01	0.096
Serotonin receptors	R-HSA-390666	8.013212e-01	0.096
Reproduction	R-HSA-1474165	8.022913e-01	0.096
Ribosome-associated quality control	R-HSA-9948299	8.029649e-01	0.095
Ion channel transport	R-HSA-983712	8.031322e-01	0.095
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.049502e-01	0.094
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.049502e-01	0.094
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.074254e-01	0.093
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.074254e-01	0.093
Depurination	R-HSA-73927	8.088839e-01	0.092
mRNA Capping	R-HSA-72086	8.090471e-01	0.092
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.090471e-01	0.092
Cellular response to chemical stress	R-HSA-9711123	8.124469e-01	0.090
Protein folding	R-HSA-391251	8.124661e-01	0.090
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.124661e-01	0.090
MAPK6/MAPK4 signaling	R-HSA-5687128	8.144864e-01	0.089
Glycogen synthesis	R-HSA-3322077	8.164404e-01	0.088
Acyl chain remodelling of PI	R-HSA-1482922	8.164404e-01	0.088
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.164404e-01	0.088
Protein hydroxylation	R-HSA-9629569	8.164404e-01	0.088
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.164404e-01	0.088
Signal transduction by L1	R-HSA-445144	8.164404e-01	0.088
GPER1 signaling	R-HSA-9634597	8.236859e-01	0.084
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.237296e-01	0.084
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.237296e-01	0.084
FGFR2b ligand binding and activation	R-HSA-190377	8.245555e-01	0.084
vRNP Assembly	R-HSA-192905	8.245555e-01	0.084
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.245555e-01	0.084
vRNA Synthesis	R-HSA-192814	8.245555e-01	0.084
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.245555e-01	0.084
Chylomicron assembly	R-HSA-8963888	8.245555e-01	0.084
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.245555e-01	0.084
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.279957e-01	0.082
Potential therapeutics for SARS	R-HSA-9679191	8.319264e-01	0.080
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.330074e-01	0.079
PKA-mediated phosphorylation of CREB	R-HSA-111931	8.330074e-01	0.079
Early Phase of HIV Life Cycle	R-HSA-162594	8.330074e-01	0.079
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.343708e-01	0.079
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.343708e-01	0.079
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.349242e-01	0.078
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.349242e-01	0.078
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.351989e-01	0.078
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.374361e-01	0.077
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.374361e-01	0.077
Regulation of T cell activation by CD28 family	R-HSA-388841	8.412102e-01	0.075
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.448136e-01	0.073
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.448805e-01	0.073
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.450739e-01	0.073
PI3K events in ERBB4 signaling	R-HSA-1250342	8.450739e-01	0.073
Integration of provirus	R-HSA-162592	8.450739e-01	0.073
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.450739e-01	0.073
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.450739e-01	0.073
Plasmalogen biosynthesis	R-HSA-75896	8.450739e-01	0.073
ERKs are inactivated	R-HSA-202670	8.450739e-01	0.073
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.450739e-01	0.073
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.450739e-01	0.073
Regulation of RAS by GAPs	R-HSA-5658442	8.455696e-01	0.073
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.460111e-01	0.073
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.471511e-01	0.072
Attachment and Entry	R-HSA-9694614	8.482115e-01	0.071
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	8.482115e-01	0.071
Assembly Of The HIV Virion	R-HSA-175474	8.482115e-01	0.071
Activation of HOX genes during differentiation	R-HSA-5619507	8.511241e-01	0.070
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.511241e-01	0.070
Activation of NF-kappaB in B cells	R-HSA-1169091	8.556410e-01	0.068
Viral Messenger RNA Synthesis	R-HSA-168325	8.564536e-01	0.067
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.569530e-01	0.067
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.569530e-01	0.067
HIV Transcription Initiation	R-HSA-167161	8.569530e-01	0.067
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.569530e-01	0.067
Intra-Golgi traffic	R-HSA-6811438	8.569530e-01	0.067
Hedgehog 'on' state	R-HSA-5632684	8.585088e-01	0.066
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.585088e-01	0.066
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.621041e-01	0.064
LDL clearance	R-HSA-8964038	8.621446e-01	0.064
VLDLR internalisation and degradation	R-HSA-8866427	8.631937e-01	0.064
Interleukin-35 Signalling	R-HSA-8984722	8.631937e-01	0.064
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.631937e-01	0.064
Diseases associated with surfactant metabolism	R-HSA-5687613	8.631937e-01	0.064
Pervasive developmental disorders	R-HSA-9005895	8.631937e-01	0.064
Disorders of Nervous System Development	R-HSA-9697154	8.631937e-01	0.064
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.631937e-01	0.064
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.631937e-01	0.064
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.631937e-01	0.064
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.631937e-01	0.064
Signaling by Hedgehog	R-HSA-5358351	8.643994e-01	0.063
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.651581e-01	0.063
Uptake and actions of bacterial toxins	R-HSA-5339562	8.651581e-01	0.063
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.652851e-01	0.063
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.672252e-01	0.062
MHC class II antigen presentation	R-HSA-2132295	8.672502e-01	0.062
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.672857e-01	0.062
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.672857e-01	0.062
Synthesis of DNA	R-HSA-69239	8.717458e-01	0.060
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.724945e-01	0.059
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.731579e-01	0.059
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.741413e-01	0.058
Regulation of PTEN stability and activity	R-HSA-8948751	8.741413e-01	0.058
Switching of origins to a post-replicative state	R-HSA-69052	8.745495e-01	0.058
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.748960e-01	0.058
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.748960e-01	0.058
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.748960e-01	0.058
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.748960e-01	0.058
Carnitine shuttle	R-HSA-200425	8.748960e-01	0.058
RNA Polymerase II Promoter Escape	R-HSA-73776	8.768568e-01	0.057
Defective pyroptosis	R-HSA-9710421	8.768568e-01	0.057
Response of Mtb to phagocytosis	R-HSA-9637690	8.768568e-01	0.057
G alpha (q) signalling events	R-HSA-416476	8.778840e-01	0.057
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.789952e-01	0.056
Acetylcholine binding and downstream events	R-HSA-181431	8.791952e-01	0.056
Adenylate cyclase activating pathway	R-HSA-170660	8.791952e-01	0.056
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.791952e-01	0.056
FGFR2c ligand binding and activation	R-HSA-190375	8.791952e-01	0.056
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.791952e-01	0.056
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.791952e-01	0.056
FGFR4 ligand binding and activation	R-HSA-190322	8.791952e-01	0.056
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.791952e-01	0.056
Mtb iron assimilation by chelation	R-HSA-1222449	8.791952e-01	0.056
Formation of axial mesoderm	R-HSA-9796292	8.791952e-01	0.056
FGFR3 mutant receptor activation	R-HSA-2033514	8.791952e-01	0.056
rRNA modification in the mitochondrion	R-HSA-6793080	8.791952e-01	0.056
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.791952e-01	0.056
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.791952e-01	0.056
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.791952e-01	0.056
Platelet Adhesion to exposed collagen	R-HSA-75892	8.791952e-01	0.056
Gastrulation	R-HSA-9758941	8.800384e-01	0.055
Hedgehog 'off' state	R-HSA-5610787	8.812827e-01	0.055
Signaling by NOTCH4	R-HSA-9013694	8.819874e-01	0.055
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.826111e-01	0.054
Metabolism of RNA	R-HSA-8953854	8.828342e-01	0.054
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.834195e-01	0.054
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.834195e-01	0.054
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.834195e-01	0.054
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.848637e-01	0.053
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.848637e-01	0.053
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.848637e-01	0.053
DAP12 interactions	R-HSA-2172127	8.858771e-01	0.053
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.865516e-01	0.052
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.865516e-01	0.052
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.865516e-01	0.052
TNFs bind their physiological receptors	R-HSA-5669034	8.865516e-01	0.052
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.905885e-01	0.050
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.914498e-01	0.050
Removal of the Flap Intermediate	R-HSA-69166	8.933259e-01	0.049
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.933259e-01	0.049
Retrograde neurotrophin signalling	R-HSA-177504	8.933259e-01	0.049
FGFR3c ligand binding and activation	R-HSA-190372	8.933259e-01	0.049
Transport of fatty acids	R-HSA-804914	8.933259e-01	0.049
Hydrolysis of LPC	R-HSA-1483115	8.933259e-01	0.049
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.933259e-01	0.049
Physiological factors	R-HSA-5578768	8.933259e-01	0.049
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.943153e-01	0.049
Nucleosome assembly	R-HSA-774815	8.943153e-01	0.049
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.943153e-01	0.049
Fanconi Anemia Pathway	R-HSA-6783310	8.943153e-01	0.049
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.971320e-01	0.047
Tight junction interactions	R-HSA-420029	8.971930e-01	0.047
Laminin interactions	R-HSA-3000157	8.971930e-01	0.047
Cell junction organization	R-HSA-446728	8.973919e-01	0.047
Mitochondrial protein degradation	R-HSA-9837999	8.974326e-01	0.047
G alpha (s) signalling events	R-HSA-418555	9.014806e-01	0.045
C-type lectin receptors (CLRs)	R-HSA-5621481	9.014806e-01	0.045
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.017451e-01	0.045
Triglyceride catabolism	R-HSA-163560	9.017451e-01	0.045
mRNA Splicing - Minor Pathway	R-HSA-72165	9.022002e-01	0.045
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.022002e-01	0.045
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.022002e-01	0.045
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.022002e-01	0.045
Regulation of CDH1 Function	R-HSA-9764561	9.051492e-01	0.043
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.056791e-01	0.043
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.058045e-01	0.043
G beta:gamma signalling through BTK	R-HSA-8964315	9.058045e-01	0.043
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.058045e-01	0.043
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.058045e-01	0.043
Lysosphingolipid and LPA receptors	R-HSA-419408	9.058045e-01	0.043
Biotin transport and metabolism	R-HSA-196780	9.058045e-01	0.043
FGFR3 ligand binding and activation	R-HSA-190239	9.058045e-01	0.043
Protein repair	R-HSA-5676934	9.058045e-01	0.043
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.058045e-01	0.043
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	9.058045e-01	0.043
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.058045e-01	0.043
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.068981e-01	0.042
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.068981e-01	0.042
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.068981e-01	0.042
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.095604e-01	0.041
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.098961e-01	0.041
NCAM1 interactions	R-HSA-419037	9.098961e-01	0.041
Adaptive Immune System	R-HSA-1280218	9.143213e-01	0.039
Cristae formation	R-HSA-8949613	9.157403e-01	0.038
RNA Polymerase I Promoter Opening	R-HSA-73728	9.157403e-01	0.038
RNA Polymerase I Transcription Termination	R-HSA-73863	9.157403e-01	0.038
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.157403e-01	0.038
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.157403e-01	0.038
Intraflagellar transport	R-HSA-5620924	9.164238e-01	0.038
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.164238e-01	0.038
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.168239e-01	0.038
Defective GALNT3 causes HFTC	R-HSA-5083625	9.168239e-01	0.038
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.168239e-01	0.038
Class I peroxisomal membrane protein import	R-HSA-9603798	9.168239e-01	0.038
Induction of Cell-Cell Fusion	R-HSA-9733458	9.168239e-01	0.038
WNT5A-dependent internalization of FZD4	R-HSA-5099900	9.168239e-01	0.038
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.168239e-01	0.038
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	9.168239e-01	0.038
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.168239e-01	0.038
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.174284e-01	0.037
PKR-mediated signaling	R-HSA-9833482	9.192503e-01	0.037
Hemostasis	R-HSA-109582	9.197994e-01	0.036
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.201580e-01	0.036
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.208484e-01	0.036
Circadian clock	R-HSA-9909396	9.227449e-01	0.035
Gap junction trafficking and regulation	R-HSA-157858	9.228176e-01	0.035
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.228176e-01	0.035
Regulation of insulin secretion	R-HSA-422356	9.233550e-01	0.035
Insulin receptor recycling	R-HSA-77387	9.237885e-01	0.034
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.237885e-01	0.034
RAB geranylgeranylation	R-HSA-8873719	9.238143e-01	0.034
Plasma lipoprotein clearance	R-HSA-8964043	9.243818e-01	0.034
Pentose phosphate pathway	R-HSA-71336	9.243818e-01	0.034
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.243818e-01	0.034
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	9.261451e-01	0.033
Acetylcholine regulates insulin secretion	R-HSA-399997	9.265549e-01	0.033
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.265549e-01	0.033
Galactose catabolism	R-HSA-70370	9.265549e-01	0.033
tRNA modification in the mitochondrion	R-HSA-6787450	9.265549e-01	0.033
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.265549e-01	0.033
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.265549e-01	0.033
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.298270e-01	0.032
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	9.307945e-01	0.031
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.307945e-01	0.031
Diseases of Immune System	R-HSA-5260271	9.307945e-01	0.031
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.307945e-01	0.031
Generation of second messenger molecules	R-HSA-202433	9.307945e-01	0.031
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.311075e-01	0.031
Glucagon-type ligand receptors	R-HSA-420092	9.311075e-01	0.031
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.311273e-01	0.031
GPCR downstream signalling	R-HSA-388396	9.324691e-01	0.030
Mitochondrial protein import	R-HSA-1268020	9.343736e-01	0.029
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.351479e-01	0.029
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.351479e-01	0.029
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.351479e-01	0.029
Glycogen storage diseases	R-HSA-3229121	9.351479e-01	0.029
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.377577e-01	0.028
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.391453e-01	0.027
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.394423e-01	0.027
Assembly of the pre-replicative complex	R-HSA-68867	9.406200e-01	0.027
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.421423e-01	0.026
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.421423e-01	0.026
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.427359e-01	0.026
Activated point mutants of FGFR2	R-HSA-2033519	9.427359e-01	0.026
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.427359e-01	0.026
PKA activation in glucagon signalling	R-HSA-164378	9.427359e-01	0.026
Transport of connexons to the plasma membrane	R-HSA-190872	9.427359e-01	0.026
PKA activation	R-HSA-163615	9.427359e-01	0.026
Molecules associated with elastic fibres	R-HSA-2129379	9.437954e-01	0.025
Cargo concentration in the ER	R-HSA-5694530	9.437954e-01	0.025
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.437954e-01	0.025
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.442141e-01	0.025
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.442141e-01	0.025
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.463305e-01	0.024
Cleavage of the damaged pyrimidine	R-HSA-110329	9.471451e-01	0.024
Depyrimidination	R-HSA-73928	9.471451e-01	0.024
UCH proteinases	R-HSA-5689603	9.482047e-01	0.023
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.486397e-01	0.023
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.486397e-01	0.023
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.494365e-01	0.023
Pyrimidine biosynthesis	R-HSA-500753	9.494365e-01	0.023
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.494365e-01	0.023
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.494365e-01	0.023
Diseases of hemostasis	R-HSA-9671793	9.494365e-01	0.023
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.494365e-01	0.023
HDL remodeling	R-HSA-8964058	9.494365e-01	0.023
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.494365e-01	0.023
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.515551e-01	0.022
G alpha (z) signalling events	R-HSA-418597	9.527410e-01	0.021
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.542383e-01	0.020
Recycling of bile acids and salts	R-HSA-159418	9.542383e-01	0.020
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.542383e-01	0.020
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.553534e-01	0.020
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.553534e-01	0.020
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.553534e-01	0.020
VxPx cargo-targeting to cilium	R-HSA-5620916	9.553534e-01	0.020
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.553534e-01	0.020
Pregnenolone biosynthesis	R-HSA-196108	9.553534e-01	0.020
Signaling by NODAL	R-HSA-1181150	9.553534e-01	0.020
Eicosanoid ligand-binding receptors	R-HSA-391903	9.553534e-01	0.020
Gap junction trafficking	R-HSA-190828	9.559647e-01	0.020
Surfactant metabolism	R-HSA-5683826	9.559647e-01	0.020
SARS-CoV-1-host interactions	R-HSA-9692914	9.560162e-01	0.020
Interferon alpha/beta signaling	R-HSA-909733	9.579260e-01	0.019
Acyl chain remodelling of PC	R-HSA-1482788	9.587368e-01	0.018
Gene Silencing by RNA	R-HSA-211000	9.587433e-01	0.018
FGFR2 ligand binding and activation	R-HSA-190241	9.605783e-01	0.017
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.605783e-01	0.017
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.605783e-01	0.017
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.605783e-01	0.017
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.613759e-01	0.017
DNA Replication	R-HSA-69306	9.618543e-01	0.017
eNOS activation	R-HSA-203615	9.628094e-01	0.016
Calnexin/calreticulin cycle	R-HSA-901042	9.628094e-01	0.016
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.628094e-01	0.016
Gap junction assembly	R-HSA-190861	9.628094e-01	0.016
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.633909e-01	0.016
DNA Replication Pre-Initiation	R-HSA-69002	9.637482e-01	0.016
Selenoamino acid metabolism	R-HSA-2408522	9.640415e-01	0.016
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.651919e-01	0.015
Androgen biosynthesis	R-HSA-193048	9.651919e-01	0.015
Molybdenum cofactor biosynthesis	R-HSA-947581	9.651919e-01	0.015
Serine metabolism	R-HSA-977347	9.651919e-01	0.015
Glutathione synthesis and recycling	R-HSA-174403	9.651919e-01	0.015
Glucocorticoid biosynthesis	R-HSA-194002	9.651919e-01	0.015
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.663046e-01	0.015
Acyl chain remodelling of PE	R-HSA-1482839	9.664943e-01	0.015
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.666456e-01	0.015
Synthesis of PC	R-HSA-1483191	9.666456e-01	0.015
NoRC negatively regulates rRNA expression	R-HSA-427413	9.673846e-01	0.014
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.680946e-01	0.014
SARS-CoV Infections	R-HSA-9679506	9.687480e-01	0.014
Cytoprotection by HMOX1	R-HSA-9707564	9.691661e-01	0.014
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.692658e-01	0.014
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.692658e-01	0.014
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.692658e-01	0.014
Cellular hexose transport	R-HSA-189200	9.692658e-01	0.014
Regulation of endogenous retroelements	R-HSA-9842860	9.695178e-01	0.013
Plasma lipoprotein remodeling	R-HSA-8963899	9.696257e-01	0.013
Gluconeogenesis	R-HSA-70263	9.696257e-01	0.013
ER to Golgi Anterograde Transport	R-HSA-199977	9.696380e-01	0.013
PRC2 methylates histones and DNA	R-HSA-212300	9.698264e-01	0.013
Lysosome Vesicle Biogenesis	R-HSA-432720	9.698264e-01	0.013
RNA Polymerase III Transcription	R-HSA-74158	9.698264e-01	0.013
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.698264e-01	0.013
FGFR2 mutant receptor activation	R-HSA-1839126	9.698264e-01	0.013
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.699003e-01	0.013
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.714235e-01	0.013
Collagen degradation	R-HSA-1442490	9.716348e-01	0.012
Degradation of CDH1	R-HSA-9766229	9.723527e-01	0.012
Degradation of DVL	R-HSA-4641258	9.728377e-01	0.012
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.728377e-01	0.012
SLC-mediated transport of organic cations	R-HSA-549127	9.728377e-01	0.012
Termination of O-glycan biosynthesis	R-HSA-977068	9.728632e-01	0.012
Formation of the ureteric bud	R-HSA-9830674	9.728632e-01	0.012
ABC transporters in lipid homeostasis	R-HSA-1369062	9.728632e-01	0.012
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.754882e-01	0.011
Elastic fibre formation	R-HSA-1566948	9.755577e-01	0.011
Co-inhibition by PD-1	R-HSA-389948	9.756734e-01	0.011
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.760396e-01	0.011
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.760396e-01	0.011
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.760396e-01	0.011
Mitochondrial RNA degradation	R-HSA-9836573	9.760396e-01	0.011
Plasma lipoprotein assembly	R-HSA-8963898	9.760396e-01	0.011
Protein ubiquitination	R-HSA-8852135	9.764087e-01	0.010
Citric acid cycle (TCA cycle)	R-HSA-71403	9.764087e-01	0.010
Hedgehog ligand biogenesis	R-HSA-5358346	9.771253e-01	0.010
The phototransduction cascade	R-HSA-2514856	9.771253e-01	0.010
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.780133e-01	0.010
RAS processing	R-HSA-9648002	9.780133e-01	0.010
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.782687e-01	0.010
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.788444e-01	0.009
Acyl chain remodelling of PS	R-HSA-1482801	9.788444e-01	0.009
Fertilization	R-HSA-1187000	9.788444e-01	0.009
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.788444e-01	0.009
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.788444e-01	0.009
Orc1 removal from chromatin	R-HSA-68949	9.792069e-01	0.009
RNA Polymerase I Promoter Escape	R-HSA-73772	9.792069e-01	0.009
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.792069e-01	0.009
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.802291e-01	0.009
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.802291e-01	0.009
PPARA activates gene expression	R-HSA-1989781	9.811385e-01	0.008
MET activates PTK2 signaling	R-HSA-8874081	9.813211e-01	0.008
Urea cycle	R-HSA-70635	9.813211e-01	0.008
Suppression of phagosomal maturation	R-HSA-9637687	9.813211e-01	0.008
RNA Polymerase I Transcription	R-HSA-73864	9.815846e-01	0.008
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.817073e-01	0.008
Beta-catenin independent WNT signaling	R-HSA-3858494	9.821946e-01	0.008
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.822277e-01	0.008
SLC-mediated transport of amino acids	R-HSA-9958863	9.832658e-01	0.007
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.833112e-01	0.007
HCMV Late Events	R-HSA-9610379	9.833112e-01	0.007
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.835079e-01	0.007
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.835079e-01	0.007
Synthesis of PE	R-HSA-1483213	9.835079e-01	0.007
Signaling by BMP	R-HSA-201451	9.835079e-01	0.007
Maturation of hRSV A proteins	R-HSA-9828806	9.835079e-01	0.007
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.840294e-01	0.007
Adherens junctions interactions	R-HSA-418990	9.850118e-01	0.007
Pyrimidine salvage	R-HSA-73614	9.854388e-01	0.006
Cytosolic tRNA aminoacylation	R-HSA-379716	9.856530e-01	0.006
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.869562e-01	0.006
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.871154e-01	0.006
DNA methylation	R-HSA-5334118	9.871437e-01	0.006
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.871781e-01	0.006
Immune System	R-HSA-168256	9.876029e-01	0.005
rRNA processing	R-HSA-72312	9.879200e-01	0.005
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.882336e-01	0.005
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.884322e-01	0.005
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.886491e-01	0.005
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.886491e-01	0.005
Formation of the cornified envelope	R-HSA-6809371	9.886838e-01	0.005
Protein localization	R-HSA-9609507	9.889761e-01	0.005
RSV-host interactions	R-HSA-9833110	9.891852e-01	0.005
Peroxisomal protein import	R-HSA-9033241	9.894558e-01	0.005
Triglyceride metabolism	R-HSA-8979227	9.894558e-01	0.005
Amino acid transport across the plasma membrane	R-HSA-352230	9.894558e-01	0.005
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.896174e-01	0.005
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.896174e-01	0.005
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.896174e-01	0.005
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.899783e-01	0.004
HCMV Early Events	R-HSA-9609690	9.902470e-01	0.004
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.903899e-01	0.004
Signaling by Retinoic Acid	R-HSA-5362517	9.904448e-01	0.004
ROS and RNS production in phagocytes	R-HSA-1222556	9.911276e-01	0.004
Formation of paraxial mesoderm	R-HSA-9793380	9.913439e-01	0.004
Endogenous sterols	R-HSA-211976	9.913439e-01	0.004
Signaling by GPCR	R-HSA-372790	9.917076e-01	0.004
HCMV Infection	R-HSA-9609646	9.921737e-01	0.003
Cell-cell junction organization	R-HSA-421270	9.925956e-01	0.003
Post-translational protein phosphorylation	R-HSA-8957275	9.926416e-01	0.003
Vpu mediated degradation of CD4	R-HSA-180534	9.931031e-01	0.003
Glucagon signaling in metabolic regulation	R-HSA-163359	9.931031e-01	0.003
Heme degradation	R-HSA-189483	9.931031e-01	0.003
Synthesis of bile acids and bile salts	R-HSA-192105	9.932291e-01	0.003
Bile acid and bile salt metabolism	R-HSA-194068	9.932582e-01	0.003
ABC-family proteins mediated transport	R-HSA-382556	9.937719e-01	0.003
Interleukin-10 signaling	R-HSA-6783783	9.938755e-01	0.003
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.939109e-01	0.003
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.939109e-01	0.003
RA biosynthesis pathway	R-HSA-5365859	9.939109e-01	0.003
Hyaluronan metabolism	R-HSA-2142845	9.939109e-01	0.003
Signal amplification	R-HSA-392518	9.939109e-01	0.003
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.944222e-01	0.002
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.944222e-01	0.002
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.946242e-01	0.002
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.946242e-01	0.002
Transferrin endocytosis and recycling	R-HSA-917977	9.946242e-01	0.002
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.951634e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.952481e-01	0.002
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.952481e-01	0.002
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.952539e-01	0.002
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.952539e-01	0.002
Amyloid fiber formation	R-HSA-977225	9.953781e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.954948e-01	0.002
FCERI mediated NF-kB activation	R-HSA-2871837	9.955211e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.956675e-01	0.002
Degradation of AXIN	R-HSA-4641257	9.958099e-01	0.002
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.958099e-01	0.002
Metabolism of folate and pterines	R-HSA-196757	9.958099e-01	0.002
Collagen chain trimerization	R-HSA-8948216	9.958099e-01	0.002
Collagen formation	R-HSA-1474290	9.961292e-01	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	9.961742e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.963008e-01	0.002
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.964620e-01	0.002
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.964933e-01	0.002
COPII-mediated vesicle transport	R-HSA-204005	9.964933e-01	0.002
Stabilization of p53	R-HSA-69541	9.967342e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.967342e-01	0.001
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.967342e-01	0.001
tRNA processing	R-HSA-72306	9.967604e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.968328e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.968900e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.970469e-01	0.001
rRNA processing in the mitochondrion	R-HSA-8868766	9.971169e-01	0.001
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.971402e-01	0.001
Synthesis of PA	R-HSA-1483166	9.972165e-01	0.001
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.972639e-01	0.001
Leishmania phagocytosis	R-HSA-9664417	9.972639e-01	0.001
Parasite infection	R-HSA-9664407	9.972639e-01	0.001
Hh mutants are degraded by ERAD	R-HSA-5362768	9.974547e-01	0.001
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.974547e-01	0.001
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.974547e-01	0.001
Degradation of CRY and PER proteins	R-HSA-9932298	9.977530e-01	0.001
Scavenging by Class A Receptors	R-HSA-3000480	9.977530e-01	0.001
tRNA Aminoacylation	R-HSA-379724	9.980067e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.980163e-01	0.001
SLC transporter disorders	R-HSA-5619102	9.980959e-01	0.001
Neddylation	R-HSA-8951664	9.981135e-01	0.001
Aquaporin-mediated transport	R-HSA-445717	9.982173e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.982263e-01	0.001
Defensins	R-HSA-1461973	9.982488e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.984583e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.984583e-01	0.001
PCP/CE pathway	R-HSA-4086400	9.984583e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.984583e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.984684e-01	0.001
Somitogenesis	R-HSA-9824272	9.986352e-01	0.001
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.986352e-01	0.001
Leishmania infection	R-HSA-9658195	9.987351e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.987351e-01	0.001
Regulation of pyruvate metabolism	R-HSA-9861718	9.987952e-01	0.001
Cellular response to hypoxia	R-HSA-1234174	9.988615e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.989022e-01	0.000
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.989364e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.989364e-01	0.000
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.990846e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.990910e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.991880e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.991880e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.991911e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.992403e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.992684e-01	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	9.992720e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.993369e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.993523e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.993918e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.993990e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.994217e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.994217e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.994217e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.995391e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.995625e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.995980e-01	0.000
Innate Immune System	R-HSA-168249	9.996204e-01	0.000
Digestion	R-HSA-8935690	9.996539e-01	0.000
Dectin-2 family	R-HSA-5621480	9.996945e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.997619e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.997686e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.997809e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.997890e-01	0.000
Glutathione conjugation	R-HSA-156590	9.997899e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.998022e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.998145e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.998150e-01	0.000
Translation	R-HSA-72766	9.998282e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.998555e-01	0.000
Digestion and absorption	R-HSA-8963743	9.998555e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.998724e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.998724e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.998828e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.998874e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999173e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999370e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999397e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999415e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999468e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999468e-01	0.000
Purine catabolism	R-HSA-74259	9.999530e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999634e-01	0.000
Iron uptake and transport	R-HSA-917937	9.999677e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999707e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999771e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999787e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999841e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999869e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999895e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999895e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999918e-01	0.000
Keratinization	R-HSA-6805567	9.999924e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999944e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999944e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999944e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999968e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999968e-01	0.000
FCGR activation	R-HSA-2029481	9.999973e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999980e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999981e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999992e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999993e-01	0.000
Disease	R-HSA-1643685	9.999995e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999997e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999998e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999998e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999999e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	3.910192e-08	7.408
Cell Cycle, Mitotic	R-HSA-69278	6.274009e-08	7.202
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.452133e-07	6.610
Metabolism of RNA	R-HSA-8953854	4.294370e-07	6.367
Apoptotic execution phase	R-HSA-75153	4.877981e-07	6.312
Chromatin organization	R-HSA-4839726	7.594410e-07	6.120
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.215894e-07	6.035
Ribosomal scanning and start codon recognition	R-HSA-72702	6.562878e-06	5.183
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.530320e-06	5.185
M Phase	R-HSA-68886	6.379037e-06	5.195
Chromatin modifying enzymes	R-HSA-3247509	1.187626e-05	4.925
Translation initiation complex formation	R-HSA-72649	1.367605e-05	4.864
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.371443e-05	4.625
Downregulation of ERBB4 signaling	R-HSA-1253288	2.620742e-05	4.582
Eukaryotic Translation Initiation	R-HSA-72613	2.936644e-05	4.532
Cap-dependent Translation Initiation	R-HSA-72737	2.936644e-05	4.532
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.247797e-05	4.488
ISG15 antiviral mechanism	R-HSA-1169408	3.411858e-05	4.467
Downregulation of ERBB2 signaling	R-HSA-8863795	3.717905e-05	4.430
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.142628e-05	4.383
mRNA Splicing - Major Pathway	R-HSA-72163	4.909313e-05	4.309
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.490706e-05	4.260
mRNA Splicing	R-HSA-72172	7.427139e-05	4.129
Axon guidance	R-HSA-422475	7.203376e-05	4.142
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.318764e-05	4.080
Cell-Cell communication	R-HSA-1500931	1.077656e-04	3.968
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.243845e-04	3.905
SWI/SNF chromatin remodelers	R-HSA-9932451	1.356561e-04	3.868
ATP-dependent chromatin remodelers	R-HSA-9932444	1.356561e-04	3.868
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.448012e-04	3.839
Formation of a pool of free 40S subunits	R-HSA-72689	1.942366e-04	3.712
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.149941e-04	3.668
Nervous system development	R-HSA-9675108	2.396610e-04	3.620
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.835166e-04	3.547
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.896160e-04	3.538
Interleukin-12 signaling	R-HSA-9020591	2.882908e-04	3.540
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.706475e-04	3.431
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.007060e-04	3.397
Signaling by ERBB2	R-HSA-1227986	3.940859e-04	3.404
Membrane Trafficking	R-HSA-199991	3.943403e-04	3.404
Signaling by ROBO receptors	R-HSA-376176	4.366750e-04	3.360
Transcriptional Regulation by E2F6	R-HSA-8953750	4.476632e-04	3.349
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.577885e-04	3.339
Signaling by ALK in cancer	R-HSA-9700206	4.577885e-04	3.339
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.043292e-04	3.297
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.516231e-04	3.258
Mitotic Prophase	R-HSA-68875	5.608810e-04	3.251
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.256124e-04	3.139
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.256124e-04	3.139
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.700205e-04	3.113
Chaperone Mediated Autophagy	R-HSA-9613829	8.336371e-04	3.079
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	9.177605e-04	3.037
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	9.042378e-04	3.044
FLT3 signaling by CBL mutants	R-HSA-9706377	9.307657e-04	3.031
Cell-extracellular matrix interactions	R-HSA-446353	1.008195e-03	2.996
Activation of ATR in response to replication stress	R-HSA-176187	1.012137e-03	2.995
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.039623e-03	2.983
Clathrin-mediated endocytosis	R-HSA-8856828	1.086036e-03	2.964
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.088469e-03	2.963
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.138139e-03	2.944
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.174477e-03	2.930
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.174477e-03	2.930
DNA Replication Pre-Initiation	R-HSA-69002	1.248240e-03	2.904
Nephrin family interactions	R-HSA-373753	1.472580e-03	2.832
Interleukin-12 family signaling	R-HSA-447115	1.507423e-03	2.822
Cell junction organization	R-HSA-446728	1.536857e-03	2.813
Regulation of CDH1 Function	R-HSA-9764561	1.675259e-03	2.776
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.814993e-03	2.741
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.914489e-03	2.718
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.914489e-03	2.718
Cell Cycle Checkpoints	R-HSA-69620	1.864746e-03	2.729
mRNA 3'-end processing	R-HSA-72187	1.987665e-03	2.702
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.314794e-03	2.635
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.314794e-03	2.635
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.599475e-03	2.585
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.902272e-03	2.537
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	3.162419e-03	2.500
Assembly of the pre-replicative complex	R-HSA-68867	3.388349e-03	2.470
Spry regulation of FGF signaling	R-HSA-1295596	4.228654e-03	2.374
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	4.228654e-03	2.374
Regulation of signaling by CBL	R-HSA-912631	4.178217e-03	2.379
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.750621e-03	2.426
Striated Muscle Contraction	R-HSA-390522	3.750621e-03	2.426
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.839347e-03	2.416
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.194331e-03	2.377
RMTs methylate histone arginines	R-HSA-3214858	3.824612e-03	2.417
DCC mediated attractive signaling	R-HSA-418885	4.228654e-03	2.374
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.824612e-03	2.417
Nuclear Envelope Breakdown	R-HSA-2980766	4.133297e-03	2.384
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.839347e-03	2.416
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.849554e-03	2.415
Influenza Infection	R-HSA-168255	3.940668e-03	2.404
Late endosomal microautophagy	R-HSA-9615710	4.297333e-03	2.367
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.490411e-03	2.348
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.532170e-03	2.344
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.543528e-03	2.343
Glycogen synthesis	R-HSA-3322077	5.298657e-03	2.276
Activation of the pre-replicative complex	R-HSA-68962	5.201156e-03	2.284
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.342547e-03	2.272
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.342547e-03	2.272
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.668604e-03	2.247
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.671957e-03	2.246
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.573921e-03	2.182
ROBO receptors bind AKAP5	R-HSA-9010642	6.363945e-03	2.196
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.363945e-03	2.196
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.635016e-03	2.178
Long-term potentiation	R-HSA-9620244	5.939228e-03	2.226
CaM pathway	R-HSA-111997	6.315266e-03	2.200
Calmodulin induced events	R-HSA-111933	6.315266e-03	2.200
Mitotic Prometaphase	R-HSA-68877	6.247597e-03	2.204
Eukaryotic Translation Elongation	R-HSA-156842	6.282572e-03	2.202
Smooth Muscle Contraction	R-HSA-445355	5.725012e-03	2.242
FLT3 signaling in disease	R-HSA-9682385	6.315266e-03	2.200
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.363945e-03	2.196
rRNA processing	R-HSA-72312	6.865814e-03	2.163
RNA Polymerase II Transcription Termination	R-HSA-73856	6.967853e-03	2.157
VLDLR internalisation and degradation	R-HSA-8866427	7.220524e-03	2.141
Signaling by EGFR in Cancer	R-HSA-1643713	7.224856e-03	2.141
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.226376e-03	2.141
SARS-CoV-1-host interactions	R-HSA-9692914	7.530684e-03	2.123
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.804774e-03	2.055
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.804774e-03	2.055
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.804774e-03	2.055
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.804774e-03	2.055
Interaction between L1 and Ankyrins	R-HSA-445095	8.712997e-03	2.060
Transport of the SLBP independent Mature mRNA	R-HSA-159227	8.824580e-03	2.054
Peptide chain elongation	R-HSA-156902	7.665439e-03	2.115
Unwinding of DNA	R-HSA-176974	9.042590e-03	2.044
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	9.042590e-03	2.044
Adherens junctions interactions	R-HSA-418990	7.557896e-03	2.122
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.946663e-03	2.100
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.877955e-03	2.052
Signaling by PTK6	R-HSA-8848021	8.877955e-03	2.052
G2/M Checkpoints	R-HSA-69481	9.095330e-03	2.041
Apoptosis	R-HSA-109581	9.494192e-03	2.023
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.534138e-03	2.021
S Phase	R-HSA-69242	1.029548e-02	1.987
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.030292e-02	1.987
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.034488e-02	1.985
Maturation of protein E	R-HSA-9683683	1.034488e-02	1.985
Maturation of protein E	R-HSA-9694493	1.034488e-02	1.985
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.038507e-02	1.984
G2/M Transition	R-HSA-69275	1.087658e-02	1.964
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.096506e-02	1.960
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.096506e-02	1.960
DAG and IP3 signaling	R-HSA-1489509	1.104375e-02	1.957
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.104375e-02	1.957
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.137161e-02	1.944
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.233259e-02	1.909
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.233259e-02	1.909
Cellular Senescence	R-HSA-2559583	1.216209e-02	1.915
Mitotic G2-G2/M phases	R-HSA-453274	1.235597e-02	1.908
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.249613e-02	1.903
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.268422e-02	1.897
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.268422e-02	1.897
Nucleotide Excision Repair	R-HSA-5696398	1.303348e-02	1.885
HATs acetylate histones	R-HSA-3214847	1.334924e-02	1.875
PKMTs methylate histone lysines	R-HSA-3214841	1.343202e-02	1.872
FLT3 Signaling	R-HSA-9607240	1.343202e-02	1.872
Ribosome-associated quality control	R-HSA-9948299	1.386821e-02	1.858
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.401589e-02	1.853
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.463296e-02	1.835
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.463296e-02	1.835
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.549625e-02	1.810
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.540062e-02	1.812
DNA Replication	R-HSA-69306	1.463671e-02	1.835
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.412493e-02	1.850
p75NTR signals via NF-kB	R-HSA-193639	1.566270e-02	1.805
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.548518e-02	1.810
Selenocysteine synthesis	R-HSA-2408557	1.585164e-02	1.800
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.654290e-02	1.781
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.670481e-02	1.777
Mitotic Anaphase	R-HSA-68882	1.704121e-02	1.768
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.706896e-02	1.768
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.708574e-02	1.767
Diseases of Telomere Maintenance	R-HSA-9673013	1.885163e-02	1.725
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.885163e-02	1.725
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.885163e-02	1.725
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.885163e-02	1.725
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.885163e-02	1.725
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.885163e-02	1.725
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.878984e-02	1.726
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.900438e-02	1.721
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.900438e-02	1.721
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.854754e-02	1.732
Regulation of endogenous retroelements	R-HSA-9842860	1.723361e-02	1.764
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.817147e-02	1.741
HDMs demethylate histones	R-HSA-3214842	1.741827e-02	1.759
Ca-dependent events	R-HSA-111996	1.755482e-02	1.756
Epigenetic regulation of gene expression	R-HSA-212165	1.856592e-02	1.731
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.854754e-02	1.732
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.801757e-02	1.744
Eukaryotic Translation Termination	R-HSA-72764	1.772736e-02	1.751
HIV Life Cycle	R-HSA-162587	1.907517e-02	1.720
Negative regulation of FLT3	R-HSA-9706369	1.956798e-02	1.708
Metalloprotease DUBs	R-HSA-5689901	2.056514e-02	1.687
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.096542e-02	1.678
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.149773e-02	1.668
NF-kB is activated and signals survival	R-HSA-209560	2.149773e-02	1.668
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.149773e-02	1.668
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.151093e-02	1.667
Regulation of PTEN localization	R-HSA-8948747	2.151093e-02	1.667
Programmed Cell Death	R-HSA-5357801	2.241727e-02	1.649
Regulation of MECP2 expression and activity	R-HSA-9022692	2.294931e-02	1.639
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.294931e-02	1.639
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.332524e-02	1.632
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.336431e-02	1.631
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.464758e-02	1.608
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.464758e-02	1.608
AURKA Activation by TPX2	R-HSA-8854518	2.574214e-02	1.589
Post NMDA receptor activation events	R-HSA-438064	2.634748e-02	1.579
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.408797e-02	1.618
Mitotic Spindle Checkpoint	R-HSA-69618	2.663486e-02	1.575
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.581857e-02	1.588
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.732870e-02	1.563
Orc1 removal from chromatin	R-HSA-68949	2.584674e-02	1.588
EPH-Ephrin signaling	R-HSA-2682334	2.349408e-02	1.629
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.483252e-02	1.605
Switching of origins to a post-replicative state	R-HSA-69052	2.535977e-02	1.596
MAPK family signaling cascades	R-HSA-5683057	2.565008e-02	1.591
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.552535e-02	1.593
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.464758e-02	1.608
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	2.732870e-02	1.563
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	2.732870e-02	1.563
p75NTR recruits signalling complexes	R-HSA-209543	2.732870e-02	1.563
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.777504e-02	1.556
Glycogen metabolism	R-HSA-8982491	2.777504e-02	1.556
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.777504e-02	1.556
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.777504e-02	1.556
Condensation of Prophase Chromosomes	R-HSA-2299718	2.851984e-02	1.545
Signaling by RAS mutants	R-HSA-6802949	2.851984e-02	1.545
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.851984e-02	1.545
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.851984e-02	1.545
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.851984e-02	1.545
Signaling downstream of RAS mutants	R-HSA-9649948	2.851984e-02	1.545
Type I hemidesmosome assembly	R-HSA-446107	2.908004e-02	1.536
Modulation by Mtb of host immune system	R-HSA-9637628	2.908004e-02	1.536
Signaling by Hippo	R-HSA-2028269	2.925752e-02	1.534
Regulation of FZD by ubiquitination	R-HSA-4641263	2.925752e-02	1.534
Glycogen storage diseases	R-HSA-3229121	2.925752e-02	1.534
Cell-cell junction organization	R-HSA-421270	2.969630e-02	1.527
Nuclear import of Rev protein	R-HSA-180746	3.015072e-02	1.521
DNA Repair	R-HSA-73894	3.094232e-02	1.509
SARS-CoV-2-host interactions	R-HSA-9705683	3.197870e-02	1.495
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.761706e-02	1.425
IRS activation	R-HSA-74713	3.761706e-02	1.425
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.804201e-02	1.420
Gap junction degradation	R-HSA-190873	3.804201e-02	1.420
PKA activation	R-HSA-163615	3.510636e-02	1.455
Termination of translesion DNA synthesis	R-HSA-5656169	3.238736e-02	1.490
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.718498e-02	1.430
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.428572e-02	1.465
PRC2 methylates histones and DNA	R-HSA-212300	3.879536e-02	1.411
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.524656e-02	1.453
Viral mRNA Translation	R-HSA-192823	3.339971e-02	1.476
Oncogenic MAPK signaling	R-HSA-6802957	3.786355e-02	1.422
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.718498e-02	1.430
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.238736e-02	1.490
Signaling by RAF1 mutants	R-HSA-9656223	3.524656e-02	1.453
RET signaling	R-HSA-8853659	3.879536e-02	1.411
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.268885e-02	1.486
TCF dependent signaling in response to WNT	R-HSA-201681	3.668505e-02	1.436
ESR-mediated signaling	R-HSA-8939211	3.327638e-02	1.478
Response of endothelial cells to shear stress	R-HSA-9860931	3.591549e-02	1.445
Estrogen-dependent gene expression	R-HSA-9018519	3.418288e-02	1.466
Semaphorin interactions	R-HSA-373755	3.826555e-02	1.417
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.510636e-02	1.455
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.554238e-02	1.449
DNA Double-Strand Break Repair	R-HSA-5693532	3.894441e-02	1.410
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.902889e-02	1.409
Signaling by EGFR	R-HSA-177929	3.902889e-02	1.409
G alpha (12/13) signalling events	R-HSA-416482	3.930491e-02	1.406
DNA Damage Bypass	R-HSA-73893	3.947434e-02	1.404
Manipulation of host energy metabolism	R-HSA-9636667	3.963785e-02	1.402
Signaling by TCF7L2 mutants	R-HSA-5339700	3.963785e-02	1.402
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	3.963785e-02	1.402
Breakdown of the nuclear lamina	R-HSA-352238	3.963785e-02	1.402
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.980368e-02	1.400
G1/S Transition	R-HSA-69206	4.045885e-02	1.393
Amplification of signal from the kinetochores	R-HSA-141424	4.097218e-02	1.388
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.097218e-02	1.388
Translesion Synthesis by POLH	R-HSA-110320	4.165869e-02	1.380
2-LTR circle formation	R-HSA-164843	4.841471e-02	1.315
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.043834e-02	1.297
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.043834e-02	1.297
EGFR downregulation	R-HSA-182971	4.243795e-02	1.372
Trafficking of AMPA receptors	R-HSA-399719	4.243795e-02	1.372
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.243795e-02	1.372
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.243795e-02	1.372
Dual incision in TC-NER	R-HSA-6782135	4.713829e-02	1.327
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.808651e-02	1.318
Signaling by ERBB4	R-HSA-1236394	5.212699e-02	1.283
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.841471e-02	1.315
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.177417e-02	1.379
DNA strand elongation	R-HSA-69190	4.815933e-02	1.317
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.159793e-02	1.287
Translesion synthesis by REV1	R-HSA-110312	5.043834e-02	1.297
Regulation of KIT signaling	R-HSA-1433559	4.177417e-02	1.379
Separation of Sister Chromatids	R-HSA-2467813	4.593100e-02	1.338
Late Phase of HIV Life Cycle	R-HSA-162599	5.169675e-02	1.287
Defective pyroptosis	R-HSA-9710421	4.401293e-02	1.356
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.043834e-02	1.297
Negative regulation of MET activity	R-HSA-6807004	4.893292e-02	1.310
Evasion by RSV of host interferon responses	R-HSA-9833109	4.243795e-02	1.372
Vesicle-mediated transport	R-HSA-5653656	4.840880e-02	1.315
Josephin domain DUBs	R-HSA-5689877	4.841471e-02	1.315
Muscle contraction	R-HSA-397014	4.829675e-02	1.316
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.893292e-02	1.310
Apoptosis induced DNA fragmentation	R-HSA-140342	4.841471e-02	1.315
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.169675e-02	1.287
Transcriptional regulation by small RNAs	R-HSA-5578749	4.426921e-02	1.354
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.841471e-02	1.315
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.808651e-02	1.318
Sensory processing of sound	R-HSA-9659379	4.264787e-02	1.370
Pexophagy	R-HSA-9664873	4.841471e-02	1.315
RAF/MAP kinase cascade	R-HSA-5673001	5.227712e-02	1.282
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.269819e-02	1.278
Formation of RNA Pol II elongation complex	R-HSA-112382	5.305580e-02	1.275
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.305580e-02	1.275
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.338122e-02	1.273
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.387758e-02	1.269
DNA Double Strand Break Response	R-HSA-5693606	5.428191e-02	1.265
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.435992e-02	1.265
IPs transport between nucleus and cytosol	R-HSA-1855170	5.435992e-02	1.265
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.435992e-02	1.265
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.435992e-02	1.265
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.007805e-02	1.221
Translesion synthesis by POLI	R-HSA-5656121	6.007805e-02	1.221
Disorders of Developmental Biology	R-HSA-9675151	7.069082e-02	1.151
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.069082e-02	1.151
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.069082e-02	1.151
Translesion synthesis by POLK	R-HSA-5655862	7.069082e-02	1.151
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.069082e-02	1.151
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.569116e-02	1.182
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.569116e-02	1.182
RAF activation	R-HSA-5673000	6.823004e-02	1.166
Dual Incision in GG-NER	R-HSA-5696400	6.823004e-02	1.166
Aggrephagy	R-HSA-9646399	6.080163e-02	1.216
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.820206e-02	1.235
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.820206e-02	1.235
HDACs deacetylate histones	R-HSA-3214815	6.945701e-02	1.158
Centrosome maturation	R-HSA-380287	5.639530e-02	1.249
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	5.627112e-02	1.250
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.794147e-02	1.168
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.733676e-02	1.172
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	5.694156e-02	1.245
UCH proteinases	R-HSA-5689603	6.089566e-02	1.215
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.823004e-02	1.166
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.694156e-02	1.245
Glucagon signaling in metabolic regulation	R-HSA-163359	6.104815e-02	1.214
PLC beta mediated events	R-HSA-112043	6.135633e-02	1.212
Homology Directed Repair	R-HSA-5693538	6.521493e-02	1.186
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.823004e-02	1.166
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.569116e-02	1.182
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.733676e-02	1.172
tRNA processing in the nucleus	R-HSA-6784531	6.666469e-02	1.176
MAPK1/MAPK3 signaling	R-HSA-5684996	6.830729e-02	1.166
Autophagy	R-HSA-9612973	7.048404e-02	1.152
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.572144e-02	1.182
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.007805e-02	1.221
Macroautophagy	R-HSA-1632852	7.184315e-02	1.144
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.889041e-02	1.162
Signaling by VEGF	R-HSA-194138	6.514827e-02	1.186
HIV Infection	R-HSA-162906	6.500424e-02	1.187
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.689957e-02	1.245
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.589246e-02	1.181
NOD1/2 Signaling Pathway	R-HSA-168638	6.823004e-02	1.166
Interactions of Rev with host cellular proteins	R-HSA-177243	6.080163e-02	1.216
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.226431e-02	1.141
Regulation of PTEN gene transcription	R-HSA-8943724	5.633556e-02	1.249
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.069082e-02	1.151
MAPK6/MAPK4 signaling	R-HSA-5687128	6.699730e-02	1.174
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.104815e-02	1.214
Regulation of BACH1 activity	R-HSA-9708530	6.007805e-02	1.221
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.893017e-02	1.162
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.694156e-02	1.245
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.366765e-02	1.196
Assembly Of The HIV Virion	R-HSA-175474	6.569116e-02	1.182
Transcriptional regulation by RUNX1	R-HSA-8878171	6.229592e-02	1.206
p75 NTR receptor-mediated signalling	R-HSA-193704	7.310820e-02	1.136
Regulation of NF-kappa B signaling	R-HSA-9758274	6.007805e-02	1.221
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.569116e-02	1.182
Integration of provirus	R-HSA-162592	7.334386e-02	1.135
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.334386e-02	1.135
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.334446e-02	1.135
Cellular responses to mechanical stimuli	R-HSA-9855142	7.334446e-02	1.135
Negative regulation of MAPK pathway	R-HSA-5675221	7.429609e-02	1.129
FGFR2 alternative splicing	R-HSA-6803529	7.518240e-02	1.124
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.518240e-02	1.124
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.518240e-02	1.124
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.557361e-02	1.122
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.645708e-02	1.117
Cellular response to starvation	R-HSA-9711097	7.773917e-02	1.109
Synthesis of DNA	R-HSA-69239	7.785476e-02	1.109
Degradation of CDH1	R-HSA-9766229	7.876303e-02	1.104
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.001126e-02	1.097
Signaling by FGFR2	R-HSA-5654738	8.128506e-02	1.090
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.168196e-02	1.088
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.201990e-02	1.086
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.226409e-02	1.085
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.226409e-02	1.085
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.408652e-02	1.075
Cellular response to hypoxia	R-HSA-1234174	8.434803e-02	1.074
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.556838e-02	1.068
Regulation of RAS by GAPs	R-HSA-5658442	8.584246e-02	1.066
Processing of DNA double-strand break ends	R-HSA-5693607	8.699179e-02	1.061
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	8.743647e-02	1.058
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.757843e-02	1.058
Diseases of programmed cell death	R-HSA-9645723	8.757843e-02	1.058
Oxidative Stress Induced Senescence	R-HSA-2559580	8.773805e-02	1.057
SOS-mediated signalling	R-HSA-112412	8.778134e-02	1.057
Cohesin Loading onto Chromatin	R-HSA-2470946	8.778134e-02	1.057
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.782395e-02	1.056
Pervasive developmental disorders	R-HSA-9005895	8.782395e-02	1.056
Disorders of Nervous System Development	R-HSA-9697154	8.782395e-02	1.056
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.782395e-02	1.056
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.782395e-02	1.056
IRAK1 recruits IKK complex	R-HSA-937039	8.782395e-02	1.056
Host Interactions of HIV factors	R-HSA-162909	9.098944e-02	1.041
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	9.276079e-02	1.033
Ovarian tumor domain proteases	R-HSA-5689896	9.276079e-02	1.033
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.477593e-02	1.023
PKA activation in glucagon signalling	R-HSA-164378	9.477593e-02	1.023
Ephrin signaling	R-HSA-3928664	9.477593e-02	1.023
Polo-like kinase mediated events	R-HSA-156711	9.477593e-02	1.023
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	9.477593e-02	1.023
Regulation of TP53 Activity through Methylation	R-HSA-6804760	9.477593e-02	1.023
snRNP Assembly	R-HSA-191859	9.590619e-02	1.018
Metabolism of non-coding RNA	R-HSA-194441	9.590619e-02	1.018
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	9.633337e-02	1.016
G-protein mediated events	R-HSA-112040	9.762082e-02	1.010
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.762082e-02	1.010
EPHB-mediated forward signaling	R-HSA-3928662	9.773372e-02	1.010
Netrin-1 signaling	R-HSA-373752	9.773372e-02	1.010
Opioid Signalling	R-HSA-111885	9.846831e-02	1.007
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.879373e-02	1.005
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.912704e-02	1.004
Deubiquitination	R-HSA-5688426	9.976379e-02	1.001
Intracellular signaling by second messengers	R-HSA-9006925	1.005990e-01	0.997
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.011205e-01	0.995
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.019281e-01	0.992
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.035677e-01	0.985
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.045461e-01	0.981
G0 and Early G1	R-HSA-1538133	1.055559e-01	0.977
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.055559e-01	0.977
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.063954e-01	0.973
Nucleosome assembly	R-HSA-774815	1.063954e-01	0.973
Fanconi Anemia Pathway	R-HSA-6783310	1.063954e-01	0.973
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.063954e-01	0.973
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.298782e-01	0.886
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.298782e-01	0.886
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.298782e-01	0.886
Formation of annular gap junctions	R-HSA-196025	1.085815e-01	0.964
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.310702e-01	0.882
ALK mutants bind TKIs	R-HSA-9700645	1.310702e-01	0.882
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.550185e-01	0.810
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.204974e-01	0.919
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.385248e-01	0.858
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.081959e-01	0.966
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.224859e-01	0.912
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.334008e-01	0.875
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.334008e-01	0.875
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.334008e-01	0.875
HIV elongation arrest and recovery	R-HSA-167287	1.470549e-01	0.833
Pausing and recovery of HIV elongation	R-HSA-167290	1.470549e-01	0.833
DNA methylation	R-HSA-5334118	1.613117e-01	0.792
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.613117e-01	0.792
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.217147e-01	0.915
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.154751e-01	0.938
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.093158e-01	0.961
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.249665e-01	0.903
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.348614e-01	0.870
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.268011e-01	0.897
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.360799e-01	0.866
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.264154e-01	0.898
Chromosome Maintenance	R-HSA-73886	1.187877e-01	0.925
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.397783e-01	0.855
Ub-specific processing proteases	R-HSA-5689880	1.095808e-01	0.960
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.164124e-01	0.934
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.164124e-01	0.934
EGFR Transactivation by Gastrin	R-HSA-2179392	1.550185e-01	0.810
Meiotic synapsis	R-HSA-1221632	1.093158e-01	0.961
MAP2K and MAPK activation	R-HSA-5674135	1.433693e-01	0.844
PI3K/AKT activation	R-HSA-198203	1.550185e-01	0.810
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.323146e-01	0.878
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.533192e-01	0.814
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.470549e-01	0.833
DARPP-32 events	R-HSA-180024	1.613117e-01	0.792
L1CAM interactions	R-HSA-373760	1.396409e-01	0.855
Cilium Assembly	R-HSA-5617833	1.520578e-01	0.818
Adrenoceptors	R-HSA-390696	1.085815e-01	0.964
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.575531e-01	0.803
COPI-mediated anterograde transport	R-HSA-6807878	1.548527e-01	0.810
MTOR signalling	R-HSA-165159	1.548639e-01	0.810
Selective autophagy	R-HSA-9663891	1.415070e-01	0.849
Platelet degranulation	R-HSA-114608	1.114019e-01	0.953
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.203823e-01	0.919
Mitophagy	R-HSA-5205647	1.397783e-01	0.855
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.433693e-01	0.844
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.433693e-01	0.844
Cyclin E associated events during G1/S transition	R-HSA-69202	1.197559e-01	0.922
Signaling by WNT	R-HSA-195721	1.309218e-01	0.883
Signal attenuation	R-HSA-74749	1.550185e-01	0.810
RNA Polymerase I Transcription	R-HSA-73864	1.197152e-01	0.922
Hedgehog 'off' state	R-HSA-5610787	1.238602e-01	0.907
Interleukin-7 signaling	R-HSA-1266695	1.080284e-01	0.966
RNA Polymerase I Promoter Opening	R-HSA-73728	1.334008e-01	0.875
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.417930e-01	0.848
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.359721e-01	0.867
NRIF signals cell death from the nucleus	R-HSA-205043	1.204974e-01	0.919
Regulation of necroptotic cell death	R-HSA-5675482	1.164124e-01	0.934
Signaling by PDGFR in disease	R-HSA-9671555	1.534911e-01	0.814
Cellular responses to stimuli	R-HSA-8953897	1.454574e-01	0.837
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.334008e-01	0.875
TNF signaling	R-HSA-75893	1.360799e-01	0.866
Glycolysis	R-HSA-70171	1.238602e-01	0.907
Cellular response to mitochondrial stress	R-HSA-9840373	1.310702e-01	0.882
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.385248e-01	0.858
Plasma lipoprotein clearance	R-HSA-8964043	1.115822e-01	0.952
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.363628e-01	0.865
Death Receptor Signaling	R-HSA-73887	1.376821e-01	0.861
Signaling by NOTCH3	R-HSA-9012852	1.268011e-01	0.897
Sema4D in semaphorin signaling	R-HSA-400685	1.080284e-01	0.966
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.385248e-01	0.858
Signaling by NOTCH4	R-HSA-9013694	1.533192e-01	0.814
Gene Silencing by RNA	R-HSA-211000	1.222908e-01	0.913
NRAGE signals death through JNK	R-HSA-193648	1.360799e-01	0.866
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.376011e-01	0.861
SARS-CoV-1 Infection	R-HSA-9678108	1.190052e-01	0.924
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.624031e-01	0.789
NrCAM interactions	R-HSA-447038	1.656173e-01	0.781
Reelin signalling pathway	R-HSA-8866376	1.656173e-01	0.781
Co-inhibition by BTLA	R-HSA-9927353	1.656173e-01	0.781
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.656173e-01	0.781
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.656173e-01	0.781
NOSIP mediated eNOS trafficking	R-HSA-203754	1.656173e-01	0.781
Signaling by SCF-KIT	R-HSA-1433557	1.667817e-01	0.778
Signaling by FGFR4	R-HSA-5654743	1.667817e-01	0.778
Signal Transduction	R-HSA-162582	1.690628e-01	0.772
Notch-HLH transcription pathway	R-HSA-350054	1.701005e-01	0.769
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.701005e-01	0.769
mTORC1-mediated signalling	R-HSA-166208	1.701005e-01	0.769
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.717516e-01	0.765
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.743520e-01	0.759
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.749397e-01	0.757
Interleukin-37 signaling	R-HSA-9008059	1.761355e-01	0.754
Kinesins	R-HSA-983189	1.765831e-01	0.753
G beta:gamma signalling through CDC42	R-HSA-8964616	1.774799e-01	0.751
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.774799e-01	0.751
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.774799e-01	0.751
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.774799e-01	0.751
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.774799e-01	0.751
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.774799e-01	0.751
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.774799e-01	0.751
Meiosis	R-HSA-1500620	1.779696e-01	0.750
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.782615e-01	0.749
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.786555e-01	0.748
Viral Messenger RNA Synthesis	R-HSA-168325	1.875048e-01	0.727
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.878325e-01	0.726
TICAM1 deficiency - HSE	R-HSA-5602566	1.878325e-01	0.726
Inhibition of PKR	R-HSA-169131	1.878325e-01	0.726
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.880581e-01	0.726
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.900006e-01	0.721
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.912121e-01	0.718
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.914875e-01	0.718
Budding and maturation of HIV virion	R-HSA-162588	1.914875e-01	0.718
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.914875e-01	0.718
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	1.918120e-01	0.717
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.918120e-01	0.717
Signaling by FGFR3	R-HSA-5654741	1.918120e-01	0.717
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.925379e-01	0.715
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.950593e-01	0.710
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.981988e-01	0.703
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.987208e-01	0.702
Cellular responses to stress	R-HSA-2262752	1.997911e-01	0.699
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.020646e-01	0.695
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.680790e-01	0.572
Defective APRT disrupts adenine salvage	R-HSA-9734195	2.680790e-01	0.572
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.680790e-01	0.572
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.680790e-01	0.572
TRAF3 deficiency - HSE	R-HSA-5602571	2.680790e-01	0.572
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.680790e-01	0.572
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.680790e-01	0.572
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.680790e-01	0.572
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.027905e-01	0.693
Cam-PDE 1 activation	R-HSA-111957	2.027905e-01	0.693
CDC6 association with the ORC:origin complex	R-HSA-68689	2.027905e-01	0.693
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.027905e-01	0.693
Regulation of cortical dendrite branching	R-HSA-8985801	3.404010e-01	0.468
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.404010e-01	0.468
Glycogen storage disease type 0 (liver GYS2)	R-HSA-3858516	3.404010e-01	0.468
Defective AHCY causes HMAHCHD	R-HSA-5578997	3.404010e-01	0.468
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.404010e-01	0.468
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.404010e-01	0.468
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	3.404010e-01	0.468
Signaling by RAS GAP mutants	R-HSA-9753510	3.404010e-01	0.468
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.407660e-01	0.618
Signaling by LTK in cancer	R-HSA-9842640	2.407660e-01	0.618
Autointegration results in viral DNA circles	R-HSA-177539	2.407660e-01	0.618
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	2.407660e-01	0.618
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.407660e-01	0.618
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.407660e-01	0.618
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.063743e-01	0.685
Signaling by GSK3beta mutants	R-HSA-5339716	2.063743e-01	0.685
MECP2 regulates transcription factors	R-HSA-9022707	2.790228e-01	0.554
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.790228e-01	0.554
Recycling of eIF2:GDP	R-HSA-72731	2.790228e-01	0.554
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.055806e-01	0.392
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.055806e-01	0.392
Axonal growth stimulation	R-HSA-209563	4.055806e-01	0.392
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.055806e-01	0.392
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.055806e-01	0.392
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	4.055806e-01	0.392
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	4.055806e-01	0.392
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	4.055806e-01	0.392
Leading Strand Synthesis	R-HSA-69109	2.333364e-01	0.632
Polymerase switching	R-HSA-69091	2.333364e-01	0.632
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.333364e-01	0.632
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.333364e-01	0.632
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.333364e-01	0.632
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.333364e-01	0.632
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.333364e-01	0.632
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.171349e-01	0.499
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.608744e-01	0.584
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.196018e-01	0.658
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.547578e-01	0.450
Lipophagy	R-HSA-9613354	3.547578e-01	0.450
Inactivation of CDC42 and RAC1	R-HSA-428543	3.547578e-01	0.450
Polymerase switching on the C-strand of the telomere	R-HSA-174411	2.236397e-01	0.650
Erythropoietin activates RAS	R-HSA-9027284	3.169160e-01	0.499
Beta-catenin phosphorylation cascade	R-HSA-196299	3.169160e-01	0.499
G beta:gamma signalling through BTK	R-HSA-8964315	3.169160e-01	0.499
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.916162e-01	0.407
Folding of actin by CCT/TriC	R-HSA-390450	3.916162e-01	0.407
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.916162e-01	0.407
EPHA-mediated growth cone collapse	R-HSA-3928663	2.617826e-01	0.582
Packaging Of Telomere Ends	R-HSA-171306	2.617826e-01	0.582
Phosphorylation of the APC/C	R-HSA-176412	3.450760e-01	0.462
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.450760e-01	0.462
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.215177e-01	0.655
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.365533e-01	0.626
Recycling pathway of L1	R-HSA-437239	2.182956e-01	0.661
Interleukin receptor SHC signaling	R-HSA-912526	3.564722e-01	0.448
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.564722e-01	0.448
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.564722e-01	0.448
mRNA Splicing - Minor Pathway	R-HSA-72165	3.323289e-01	0.478
Nuclear Receptor transcription pathway	R-HSA-383280	2.872401e-01	0.542
Nuclear signaling by ERBB4	R-HSA-1251985	3.645140e-01	0.438
Protein ubiquitination	R-HSA-8852135	3.642993e-01	0.439
Post-translational protein phosphorylation	R-HSA-8957275	3.485356e-01	0.458
HCMV Early Events	R-HSA-9609690	3.919255e-01	0.407
Neutrophil degranulation	R-HSA-6798695	3.908086e-01	0.408
Transcription of the HIV genome	R-HSA-167172	3.942130e-01	0.404
Telomere Maintenance	R-HSA-157579	2.402416e-01	0.619
Signaling by NOTCH2	R-HSA-1980145	2.573374e-01	0.589
Transcriptional Regulation by MECP2	R-HSA-8986944	3.494966e-01	0.457
HIV Transcription Elongation	R-HSA-167169	2.215177e-01	0.655
GPER1 signaling	R-HSA-9634597	2.320255e-01	0.634
Interferon alpha/beta signaling	R-HSA-909733	3.679169e-01	0.434
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.215177e-01	0.655
HSF1-dependent transactivation	R-HSA-3371571	2.748721e-01	0.561
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.213592e-01	0.493
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.995693e-01	0.524
Resolution of D-Loop Structures	R-HSA-5693537	4.025673e-01	0.395
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	3.281492e-01	0.484
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.822517e-01	0.418
Regulation of mitotic cell cycle	R-HSA-453276	2.058066e-01	0.687
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.058066e-01	0.687
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.731260e-01	0.428
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.389289e-01	0.470
Diseases of mitotic cell cycle	R-HSA-9675126	2.073270e-01	0.683
Regulation of CDH11 function	R-HSA-9762292	3.916162e-01	0.407
MET activates RAP1 and RAC1	R-HSA-8875555	3.916162e-01	0.407
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.068354e-01	0.684
Deadenylation-dependent mRNA decay	R-HSA-429914	2.666224e-01	0.574
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.333364e-01	0.632
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.460484e-01	0.609
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.333463e-01	0.632
Activation of HOX genes during differentiation	R-HSA-5619507	2.333463e-01	0.632
NoRC negatively regulates rRNA expression	R-HSA-427413	2.058066e-01	0.687
PI3K events in ERBB2 signaling	R-HSA-1963642	4.009333e-01	0.397
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.344408e-01	0.476
Activation of NF-kappaB in B cells	R-HSA-1169091	2.748721e-01	0.561
Signaling by WNT in cancer	R-HSA-4791275	2.073270e-01	0.683
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.680790e-01	0.572
VLDL clearance	R-HSA-8964046	2.790228e-01	0.554
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.415805e-01	0.617
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.746887e-01	0.561
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.746887e-01	0.561
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.802445e-01	0.552
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.802445e-01	0.552
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.802445e-01	0.552
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.802445e-01	0.552
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.972702e-01	0.527
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.120898e-01	0.506
Degradation of CRY and PER proteins	R-HSA-9932298	4.010585e-01	0.397
Cyclin D associated events in G1	R-HSA-69231	2.995693e-01	0.524
G1 Phase	R-HSA-69236	2.995693e-01	0.524
Signal transduction by L1	R-HSA-445144	2.640280e-01	0.578
RAS processing	R-HSA-9648002	3.462883e-01	0.461
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.027905e-01	0.693
Inhibition of nitric oxide production	R-HSA-9636249	4.055806e-01	0.392
Formation of intermediate mesoderm	R-HSA-9761174	3.916162e-01	0.407
Intra-Golgi traffic	R-HSA-6811438	4.010585e-01	0.397
Extra-nuclear estrogen signaling	R-HSA-9009391	2.816347e-01	0.550
Protein-protein interactions at synapses	R-HSA-6794362	3.760877e-01	0.425
Degradation of DVL	R-HSA-4641258	3.101399e-01	0.508
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.797771e-01	0.420
Asymmetric localization of PCP proteins	R-HSA-4608870	3.158730e-01	0.500
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.827842e-01	0.417
Cellular response to heat stress	R-HSA-3371556	2.470453e-01	0.607
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.371790e-01	0.472
Regulation of T cell activation by CD28 family	R-HSA-388841	3.579599e-01	0.446
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.080331e-01	0.511
Signaling by NOTCH1	R-HSA-1980143	2.629987e-01	0.580
Organelle biogenesis and maintenance	R-HSA-1852241	3.496994e-01	0.456
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.680790e-01	0.572
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.680790e-01	0.572
Interleukin-33 signaling	R-HSA-9014843	3.404010e-01	0.468
MET interacts with TNS proteins	R-HSA-8875513	4.055806e-01	0.392
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.055806e-01	0.392
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.171349e-01	0.499
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.052380e-01	0.688
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.547578e-01	0.450
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.813916e-01	0.551
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.923047e-01	0.534
Degradation of AXIN	R-HSA-4641257	3.101399e-01	0.508
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.101399e-01	0.508
Glycogen breakdown (glycogenolysis)	R-HSA-70221	4.029902e-01	0.395
PCP/CE pathway	R-HSA-4086400	2.872401e-01	0.542
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.802445e-01	0.552
Hedgehog 'on' state	R-HSA-5632684	2.058066e-01	0.687
FGFR1 mutant receptor activation	R-HSA-1839124	3.822517e-01	0.418
Signaling by Hedgehog	R-HSA-5358351	3.517624e-01	0.454
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.182956e-01	0.661
Interleukin-17 signaling	R-HSA-448424	2.972702e-01	0.527
Signaling by FGFR1 in disease	R-HSA-5655302	4.010585e-01	0.397
Golgi-to-ER retrograde transport	R-HSA-8856688	2.847500e-01	0.546
Aquaporin-mediated transport	R-HSA-445717	2.940551e-01	0.532
Regulation of TNFR1 signaling	R-HSA-5357905	3.323289e-01	0.478
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.462883e-01	0.461
Gene expression (Transcription)	R-HSA-74160	2.166473e-01	0.664
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.564722e-01	0.448
PTEN Regulation	R-HSA-6807070	2.759956e-01	0.559
ER to Golgi Anterograde Transport	R-HSA-199977	3.595295e-01	0.444
RSV-host interactions	R-HSA-9833110	3.250993e-01	0.488
MAP kinase activation	R-HSA-450294	2.940551e-01	0.532
Nef and signal transduction	R-HSA-164944	2.407660e-01	0.618
Basigin interactions	R-HSA-210991	2.868397e-01	0.542
Vpu mediated degradation of CD4	R-HSA-180534	2.402964e-01	0.619
Mitochondrial calcium ion transport	R-HSA-8949215	3.099146e-01	0.509
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.573374e-01	0.589
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	2.573374e-01	0.589
Regulation of Apoptosis	R-HSA-169911	2.746887e-01	0.561
Co-inhibition by PD-1	R-HSA-389948	3.473676e-01	0.459
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.445536e-01	0.463
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.270969e-01	0.644
Signaling by MET	R-HSA-6806834	3.120898e-01	0.506
Signaling by Nuclear Receptors	R-HSA-9006931	3.859320e-01	0.413
Iron uptake and transport	R-HSA-917937	3.642993e-01	0.439
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.027905e-01	0.693
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.407660e-01	0.618
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.055806e-01	0.392
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.236113e-01	0.651
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.645140e-01	0.438
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.645140e-01	0.438
Signaling by FGFR1	R-HSA-5654736	3.502448e-01	0.456
Hh mutants are degraded by ERAD	R-HSA-5362768	3.827842e-01	0.417
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.827842e-01	0.417
Glucose metabolism	R-HSA-70326	2.936919e-01	0.532
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.494966e-01	0.457
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.834515e-01	0.548
Early Phase of HIV Life Cycle	R-HSA-162594	2.868397e-01	0.542
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.021189e-01	0.396
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.010585e-01	0.397
Regulation of TP53 Degradation	R-HSA-6804757	2.923047e-01	0.534
Suppression of phagosomal maturation	R-HSA-9637687	2.425100e-01	0.615
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.236113e-01	0.651
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.331560e-01	0.477
Neurodegenerative Diseases	R-HSA-8863678	2.052380e-01	0.688
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.052380e-01	0.688
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.158730e-01	0.500
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.158730e-01	0.500
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.822773e-01	0.418
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.822773e-01	0.418
Stabilization of p53	R-HSA-69541	3.462883e-01	0.461
Regulation of TP53 Activity	R-HSA-5633007	3.107834e-01	0.508
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.462883e-01	0.461
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.404010e-01	0.468
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.617826e-01	0.582
Signaling by FGFR	R-HSA-190236	2.503630e-01	0.601
Transcriptional Regulation by TP53	R-HSA-3700989	3.302404e-01	0.481
Response of Mtb to phagocytosis	R-HSA-9637690	2.834515e-01	0.548
Inositol phosphate metabolism	R-HSA-1483249	3.140874e-01	0.503
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.617826e-01	0.582
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	3.827842e-01	0.417
Miscellaneous transport and binding events	R-HSA-5223345	4.025673e-01	0.395
Regulation of CDH11 gene transcription	R-HSA-9762293	3.547578e-01	0.450
STING mediated induction of host immune responses	R-HSA-1834941	2.415805e-01	0.617
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.027905e-01	0.693
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.171349e-01	0.499
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.048832e-01	0.688
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.619081e-01	0.441
MITF-M-dependent gene expression	R-HSA-9856651	3.026430e-01	0.519
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.868397e-01	0.542
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.731260e-01	0.428
Tandem pore domain potassium channels	R-HSA-1296346	3.916162e-01	0.407
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.573374e-01	0.589
Selenoamino acid metabolism	R-HSA-2408522	2.682214e-01	0.572
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.868397e-01	0.542
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.573374e-01	0.589
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.012718e-01	0.521
SARS-CoV-2 Infection	R-HSA-9694516	3.562425e-01	0.448
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.099146e-01	0.509
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.547578e-01	0.450
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.099146e-01	0.509
Signaling by Leptin	R-HSA-2586552	3.916162e-01	0.407
SARS-CoV Infections	R-HSA-9679506	4.098032e-01	0.387
Meiotic recombination	R-HSA-912446	4.157403e-01	0.381
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	4.157403e-01	0.381
Hedgehog ligand biogenesis	R-HSA-5358346	4.157403e-01	0.381
Cleavage of the damaged pyrimidine	R-HSA-110329	4.192978e-01	0.377
Depyrimidination	R-HSA-73928	4.192978e-01	0.377
Calnexin/calreticulin cycle	R-HSA-901042	4.228026e-01	0.374
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.233150e-01	0.373
Beta-catenin independent WNT signaling	R-HSA-3858494	4.255373e-01	0.371
Myogenesis	R-HSA-525793	4.260373e-01	0.371
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	4.260373e-01	0.371
Signaling by APC mutants	R-HSA-4839744	4.274940e-01	0.369
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.274940e-01	0.369
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.274940e-01	0.369
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.274940e-01	0.369
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.274940e-01	0.369
Formation of the posterior neural plate	R-HSA-9832991	4.274940e-01	0.369
Ionotropic activity of kainate receptors	R-HSA-451306	4.274940e-01	0.369
PECAM1 interactions	R-HSA-210990	4.274940e-01	0.369
Bicarbonate transporters	R-HSA-425381	4.274940e-01	0.369
ChREBP activates metabolic gene expression	R-HSA-163765	4.274940e-01	0.369
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.277315e-01	0.369
G beta:gamma signalling through PLC beta	R-HSA-418217	4.283807e-01	0.368
Platelet sensitization by LDL	R-HSA-432142	4.283807e-01	0.368
Presynaptic function of Kainate receptors	R-HSA-500657	4.283807e-01	0.368
RNA Polymerase I Promoter Escape	R-HSA-73772	4.324298e-01	0.364
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.324298e-01	0.364
Neurexins and neuroligins	R-HSA-6794361	4.324298e-01	0.364
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.328723e-01	0.364
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.362894e-01	0.360
TBC/RABGAPs	R-HSA-8854214	4.374650e-01	0.359
Hh mutants abrogate ligand secretion	R-HSA-5387390	4.374650e-01	0.359
PIP3 activates AKT signaling	R-HSA-1257604	4.374871e-01	0.359
Oncogene Induced Senescence	R-HSA-2559585	4.429089e-01	0.354
Amyloid fiber formation	R-HSA-977225	4.465834e-01	0.350
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.487301e-01	0.348
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.490532e-01	0.348
Signaling by NOTCH	R-HSA-157118	4.525008e-01	0.344
Downstream TCR signaling	R-HSA-202424	4.542743e-01	0.343
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.553656e-01	0.342
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.553656e-01	0.342
Specification of the neural plate border	R-HSA-9834899	4.553656e-01	0.342
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	4.553656e-01	0.342
E2F mediated regulation of DNA replication	R-HSA-113510	4.553656e-01	0.342
Rap1 signalling	R-HSA-392517	4.553656e-01	0.342
The NLRP3 inflammasome	R-HSA-844456	4.553656e-01	0.342
MHC class II antigen presentation	R-HSA-2132295	4.562014e-01	0.341
G1/S DNA Damage Checkpoints	R-HSA-69615	4.586210e-01	0.339
Interferon Signaling	R-HSA-913531	4.605277e-01	0.337
Activation of RAC1	R-HSA-428540	4.622252e-01	0.335
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.622252e-01	0.335
PI3K events in ERBB4 signaling	R-HSA-1250342	4.622252e-01	0.335
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.622252e-01	0.335
Signaling by AXIN mutants	R-HSA-4839735	4.622252e-01	0.335
Signaling by AMER1 mutants	R-HSA-4839748	4.622252e-01	0.335
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.622252e-01	0.335
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.622252e-01	0.335
Triglyceride catabolism	R-HSA-163560	4.628404e-01	0.335
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.643228e-01	0.333
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.643228e-01	0.333
Defective LFNG causes SCDO3	R-HSA-5083630	4.643228e-01	0.333
Regulation of gap junction activity	R-HSA-191650	4.643228e-01	0.333
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.643228e-01	0.333
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.643228e-01	0.333
TNFR1-mediated ceramide production	R-HSA-5626978	4.643228e-01	0.333
Electric Transmission Across Gap Junctions	R-HSA-112303	4.643228e-01	0.333
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.643228e-01	0.333
Transmission across Electrical Synapses	R-HSA-112307	4.643228e-01	0.333
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.643228e-01	0.333
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.713675e-01	0.327
Formation of the Early Elongation Complex	R-HSA-113418	4.713675e-01	0.327
Circadian clock	R-HSA-9909396	4.724529e-01	0.326
Defective CFTR causes cystic fibrosis	R-HSA-5678895	4.734440e-01	0.325
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.734440e-01	0.325
Signaling by Interleukins	R-HSA-449147	4.772778e-01	0.321
Stimuli-sensing channels	R-HSA-2672351	4.792069e-01	0.319
G2/M DNA damage checkpoint	R-HSA-69473	4.811287e-01	0.318
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.817998e-01	0.317
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.817998e-01	0.317
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.817998e-01	0.317
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.817998e-01	0.317
VxPx cargo-targeting to cilium	R-HSA-5620916	4.817998e-01	0.317
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.817998e-01	0.317
G alpha (z) signalling events	R-HSA-418597	4.819953e-01	0.317
SIRT1 negatively regulates rRNA expression	R-HSA-427359	4.825548e-01	0.316
Cleavage of the damaged purine	R-HSA-110331	4.825548e-01	0.316
Regulation of pyruvate metabolism	R-HSA-9861718	4.911912e-01	0.309
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.918396e-01	0.308
RNA Polymerase II Transcription	R-HSA-73857	4.923989e-01	0.308
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	4.930369e-01	0.307
Signaling by Erythropoietin	R-HSA-9006335	4.935330e-01	0.307
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.935330e-01	0.307
mRNA Capping	R-HSA-72086	4.935330e-01	0.307
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.935330e-01	0.307
Platelet activation, signaling and aggregation	R-HSA-76002	4.941761e-01	0.306
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.956860e-01	0.305
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.956860e-01	0.305
Maple Syrup Urine Disease	R-HSA-9865114	4.956860e-01	0.305
Interleukin-15 signaling	R-HSA-8983432	4.956860e-01	0.305
SHC-related events triggered by IGF1R	R-HSA-2428933	4.956860e-01	0.305
Serotonin clearance from the synaptic cleft	R-HSA-380615	4.956860e-01	0.305
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.956860e-01	0.305
GRB2 events in EGFR signaling	R-HSA-179812	4.956860e-01	0.305
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.956860e-01	0.305
Regulation of IFNG signaling	R-HSA-877312	4.956860e-01	0.305
Signaling by LTK	R-HSA-9842663	4.956860e-01	0.305
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.956860e-01	0.305
Repression of WNT target genes	R-HSA-4641265	4.956860e-01	0.305
OAS antiviral response	R-HSA-8983711	4.956860e-01	0.305
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.956860e-01	0.305
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.956860e-01	0.305
Rab regulation of trafficking	R-HSA-9007101	4.957558e-01	0.305
Interleukin-1 signaling	R-HSA-9020702	4.981153e-01	0.303
Interleukin-1 family signaling	R-HSA-446652	5.017940e-01	0.299
Depurination	R-HSA-73927	5.020132e-01	0.299
TCR signaling	R-HSA-202403	5.027591e-01	0.299
Lagging Strand Synthesis	R-HSA-69186	5.076079e-01	0.294
G-protein activation	R-HSA-202040	5.076079e-01	0.294
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	5.076079e-01	0.294
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.152973e-01	0.288
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.152973e-01	0.288
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.152973e-01	0.288
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.152973e-01	0.288
NTRK2 activates RAC1	R-HSA-9032759	5.172631e-01	0.286
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.172631e-01	0.286
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.172631e-01	0.286
Activation of C3 and C5	R-HSA-174577	5.172631e-01	0.286
Muscarinic acetylcholine receptors	R-HSA-390648	5.172631e-01	0.286
Interleukin-36 pathway	R-HSA-9014826	5.172631e-01	0.286
Nectin/Necl trans heterodimerization	R-HSA-420597	5.172631e-01	0.286
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.172631e-01	0.286
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.172631e-01	0.286
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.211799e-01	0.283
Signaling by ALK	R-HSA-201556	5.211799e-01	0.283
Integration of energy metabolism	R-HSA-163685	5.252092e-01	0.280
Gluconeogenesis	R-HSA-70263	5.260554e-01	0.279
NGF-stimulated transcription	R-HSA-9031628	5.260554e-01	0.279
XBP1(S) activates chaperone genes	R-HSA-381038	5.275150e-01	0.278
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.277885e-01	0.278
CD28 dependent Vav1 pathway	R-HSA-389359	5.277885e-01	0.278
Adenylate cyclase activating pathway	R-HSA-170660	5.277885e-01	0.278
Frs2-mediated activation	R-HSA-170968	5.277885e-01	0.278
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.277885e-01	0.278
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.311154e-01	0.275
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.327273e-01	0.273
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.327273e-01	0.273
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.340548e-01	0.272
Regulated Necrosis	R-HSA-5218859	5.340548e-01	0.272
Attenuation phase	R-HSA-3371568	5.400229e-01	0.268
Extension of Telomeres	R-HSA-180786	5.459918e-01	0.263
Reproduction	R-HSA-1474165	5.538833e-01	0.257
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.559697e-01	0.255
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.559697e-01	0.255
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.571065e-01	0.254
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.571065e-01	0.254
Ethanol oxidation	R-HSA-71384	5.571065e-01	0.254
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.571065e-01	0.254
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.581924e-01	0.253
CRMPs in Sema3A signaling	R-HSA-399956	5.584744e-01	0.253
Removal of the Flap Intermediate	R-HSA-69166	5.584744e-01	0.253
Signal regulatory protein family interactions	R-HSA-391160	5.584744e-01	0.253
HDL assembly	R-HSA-8963896	5.584744e-01	0.253
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	5.585132e-01	0.253
Transcriptional Regulation by VENTX	R-HSA-8853884	5.585132e-01	0.253
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	5.603325e-01	0.252
Adipogenesis	R-HSA-9843745	5.643987e-01	0.248
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.649742e-01	0.248
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.649742e-01	0.248
IkBA variant leads to EDA-ID	R-HSA-5603029	5.649742e-01	0.248
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.649742e-01	0.248
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.649742e-01	0.248
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.649742e-01	0.248
Signaling by RNF43 mutants	R-HSA-5340588	5.649742e-01	0.248
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.649742e-01	0.248
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.649742e-01	0.248
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.649742e-01	0.248
Pentose phosphate pathway disease	R-HSA-6791465	5.649742e-01	0.248
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	5.649742e-01	0.248
Signalling to p38 via RIT and RIN	R-HSA-187706	5.649742e-01	0.248
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.649742e-01	0.248
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.649742e-01	0.248
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.649742e-01	0.248
CLEC7A/inflammasome pathway	R-HSA-5660668	5.649742e-01	0.248
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.649742e-01	0.248
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.649742e-01	0.248
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.649742e-01	0.248
Translation	R-HSA-72766	5.680058e-01	0.246
Transmission across Chemical Synapses	R-HSA-112315	5.687557e-01	0.245
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.766251e-01	0.239
Translation of Structural Proteins	R-HSA-9683701	5.766251e-01	0.239
IRS-related events triggered by IGF1R	R-HSA-2428928	5.767160e-01	0.239
Formation of paraxial mesoderm	R-HSA-9793380	5.767160e-01	0.239
G-protein beta:gamma signalling	R-HSA-397795	5.777742e-01	0.238
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.777742e-01	0.238
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.777742e-01	0.238
Potential therapeutics for SARS	R-HSA-9679191	5.779931e-01	0.238
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.782147e-01	0.238
Regulation of insulin secretion	R-HSA-422356	5.803045e-01	0.236
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.807047e-01	0.236
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.807047e-01	0.236
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.807047e-01	0.236
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	5.807047e-01	0.236
Syndecan interactions	R-HSA-3000170	5.807047e-01	0.236
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.807047e-01	0.236
Growth hormone receptor signaling	R-HSA-982772	5.807047e-01	0.236
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.877100e-01	0.231
SHC1 events in EGFR signaling	R-HSA-180336	5.877100e-01	0.231
Processive synthesis on the lagging strand	R-HSA-69183	5.877100e-01	0.231
Telomere C-strand synthesis initiation	R-HSA-174430	5.877100e-01	0.231
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.877100e-01	0.231
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.877100e-01	0.231
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.877100e-01	0.231
Protein methylation	R-HSA-8876725	5.877100e-01	0.231
Formation of the anterior neural plate	R-HSA-9823739	5.877100e-01	0.231
NCAM signaling for neurite out-growth	R-HSA-375165	5.916990e-01	0.228
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.916990e-01	0.228
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.916990e-01	0.228
Activation of GABAB receptors	R-HSA-991365	5.943361e-01	0.226
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.943361e-01	0.226
GABA B receptor activation	R-HSA-977444	5.943361e-01	0.226
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.943361e-01	0.226
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.975521e-01	0.224
Deadenylation of mRNA	R-HSA-429947	6.034905e-01	0.219
Thromboxane signalling through TP receptor	R-HSA-428930	6.034905e-01	0.219
Plasma lipoprotein assembly	R-HSA-8963898	6.034905e-01	0.219
ABC-family proteins mediated transport	R-HSA-382556	6.040486e-01	0.219
IRE1alpha activates chaperones	R-HSA-381070	6.041081e-01	0.219
Cytoprotection by HMOX1	R-HSA-9707564	6.044462e-01	0.219
Ca2+ pathway	R-HSA-4086398	6.051630e-01	0.218
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.079723e-01	0.216
STAT5 Activation	R-HSA-9645135	6.079723e-01	0.216
Erythropoietin activates STAT5	R-HSA-9027283	6.079723e-01	0.216
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.079723e-01	0.216
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.079723e-01	0.216
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.079723e-01	0.216
Hydrolysis of LPE	R-HSA-1483152	6.079723e-01	0.216
HDL clearance	R-HSA-8964011	6.079723e-01	0.216
VLDL assembly	R-HSA-8866423	6.079723e-01	0.216
Neurofascin interactions	R-HSA-447043	6.079723e-01	0.216
Regulation of PTEN stability and activity	R-HSA-8948751	6.084282e-01	0.216
MyD88-independent TLR4 cascade	R-HSA-166166	6.153492e-01	0.211
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.153492e-01	0.211
Activation of SMO	R-HSA-5635838	6.154823e-01	0.211
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.154823e-01	0.211
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.154823e-01	0.211
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.154823e-01	0.211
Prolonged ERK activation events	R-HSA-169893	6.154823e-01	0.211
Phase 4 - resting membrane potential	R-HSA-5576886	6.154823e-01	0.211
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.154823e-01	0.211
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.154823e-01	0.211
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.167644e-01	0.210
eNOS activation	R-HSA-203615	6.167644e-01	0.210
Signal amplification	R-HSA-392518	6.167644e-01	0.210
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.167644e-01	0.210
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.167644e-01	0.210
Signaling by FGFR in disease	R-HSA-1226099	6.187093e-01	0.209
IGF1R signaling cascade	R-HSA-2428924	6.208365e-01	0.207
Ion transport by P-type ATPases	R-HSA-936837	6.208365e-01	0.207
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.239292e-01	0.205
G protein gated Potassium channels	R-HSA-1296059	6.254412e-01	0.204
Activation of G protein gated Potassium channels	R-HSA-1296041	6.254412e-01	0.204
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	6.254412e-01	0.204
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.254412e-01	0.204
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.254412e-01	0.204
Formation of the nephric duct	R-HSA-9830364	6.254412e-01	0.204
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.271393e-01	0.203
MITF-M-regulated melanocyte development	R-HSA-9730414	6.277262e-01	0.202
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.349673e-01	0.197
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.353930e-01	0.197
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.390719e-01	0.194
Galactose catabolism	R-HSA-70370	6.417949e-01	0.193
Acetylcholine regulates insulin secretion	R-HSA-399997	6.417949e-01	0.193
Synthesis of PG	R-HSA-1483148	6.417949e-01	0.193
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.422114e-01	0.192
Somitogenesis	R-HSA-9824272	6.448832e-01	0.191
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.465418e-01	0.189
TRP channels	R-HSA-3295583	6.465418e-01	0.189
RUNX3 regulates WNT signaling	R-HSA-8951430	6.467227e-01	0.189
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.467227e-01	0.189
TRIF-mediated programmed cell death	R-HSA-2562578	6.467227e-01	0.189
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	6.467227e-01	0.189
Disinhibition of SNARE formation	R-HSA-114516	6.467227e-01	0.189
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.467227e-01	0.189
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.467227e-01	0.189
PTK6 Expression	R-HSA-8849473	6.467227e-01	0.189
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.467227e-01	0.189
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.467227e-01	0.189
LDL remodeling	R-HSA-8964041	6.467227e-01	0.189
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.467227e-01	0.189
Cation-coupled Chloride cotransporters	R-HSA-426117	6.467227e-01	0.189
Uptake and function of diphtheria toxin	R-HSA-5336415	6.467227e-01	0.189
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.467227e-01	0.189
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.467227e-01	0.189
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.478539e-01	0.189
RNA Polymerase III Transcription	R-HSA-74158	6.534241e-01	0.185
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.534241e-01	0.185
HSF1 activation	R-HSA-3371511	6.534241e-01	0.185
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.608241e-01	0.180
Diseases of DNA repair	R-HSA-9675135	6.608241e-01	0.180
Cytokine Signaling in Immune system	R-HSA-1280215	6.611145e-01	0.180
Cellular response to chemical stress	R-HSA-9711123	6.660767e-01	0.176
Chaperonin-mediated protein folding	R-HSA-390466	6.662404e-01	0.176
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.666650e-01	0.176
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.666650e-01	0.176
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.666650e-01	0.176
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.666650e-01	0.176
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.666650e-01	0.176
Specification of primordial germ cells	R-HSA-9827857	6.666650e-01	0.176
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.667841e-01	0.176
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.667841e-01	0.176
Insulin processing	R-HSA-264876	6.667841e-01	0.176
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.667841e-01	0.176
Ion channel transport	R-HSA-983712	6.678581e-01	0.175
TRAF6 mediated IRF7 activation	R-HSA-933541	6.708478e-01	0.173
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.762942e-01	0.170
HCMV Infection	R-HSA-9609646	6.802149e-01	0.167
Activated NTRK2 signals through FYN	R-HSA-9032500	6.816449e-01	0.166
RSK activation	R-HSA-444257	6.816449e-01	0.166
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.816449e-01	0.166
Signaling by MRAS-complex mutants	R-HSA-9660537	6.816449e-01	0.166
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.816449e-01	0.166
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.816449e-01	0.166
Interleukin-9 signaling	R-HSA-8985947	6.816449e-01	0.166
Co-stimulation by ICOS	R-HSA-9927354	6.816449e-01	0.166
Activation of RAS in B cells	R-HSA-1169092	6.816449e-01	0.166
Fructose biosynthesis	R-HSA-5652227	6.816449e-01	0.166
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.816449e-01	0.166
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.816449e-01	0.166
Nucleotide salvage defects	R-HSA-9734207	6.816449e-01	0.166
Interleukin-23 signaling	R-HSA-9020933	6.816449e-01	0.166
Telomere Extension By Telomerase	R-HSA-171319	6.861664e-01	0.164
Phase 0 - rapid depolarisation	R-HSA-5576892	6.861664e-01	0.164
Inflammasomes	R-HSA-622312	6.861664e-01	0.164
MET promotes cell motility	R-HSA-8875878	6.876577e-01	0.163
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.876577e-01	0.163
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.901207e-01	0.161
GAB1 signalosome	R-HSA-180292	6.901207e-01	0.161
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.901207e-01	0.161
Mismatch Repair	R-HSA-5358508	6.901207e-01	0.161
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.901207e-01	0.161
Nephron development	R-HSA-9831926	6.901207e-01	0.161
Tie2 Signaling	R-HSA-210993	6.901207e-01	0.161
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.901207e-01	0.161
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.901207e-01	0.161
Co-stimulation by CD28	R-HSA-389356	6.912872e-01	0.160
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.955790e-01	0.158
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.955790e-01	0.158
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.955790e-01	0.158
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.958199e-01	0.158
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.958199e-01	0.158
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.958199e-01	0.158
Developmental Cell Lineages	R-HSA-9734767	7.001695e-01	0.155
Base Excision Repair	R-HSA-73884	7.004421e-01	0.155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.021060e-01	0.154
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.038507e-01	0.153
Glucagon-type ligand receptors	R-HSA-420092	7.046918e-01	0.152
Gap junction trafficking and regulation	R-HSA-157858	7.057988e-01	0.151
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.057988e-01	0.151
GABA receptor activation	R-HSA-977443	7.090932e-01	0.149
Viral Infection Pathways	R-HSA-9824446	7.095594e-01	0.149
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.120121e-01	0.148
Germ layer formation at gastrulation	R-HSA-9754189	7.121984e-01	0.147
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.121984e-01	0.147
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	7.121984e-01	0.147
O2/CO2 exchange in erythrocytes	R-HSA-1480926	7.121984e-01	0.147
Maturation of nucleoprotein	R-HSA-9694631	7.121984e-01	0.147
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.130823e-01	0.147
Interleukin-21 signaling	R-HSA-9020958	7.131167e-01	0.147
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.131167e-01	0.147
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.131167e-01	0.147
Calcineurin activates NFAT	R-HSA-2025928	7.131167e-01	0.147
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.131167e-01	0.147
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.131167e-01	0.147
p75NTR regulates axonogenesis	R-HSA-193697	7.131167e-01	0.147
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.131167e-01	0.147
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.131167e-01	0.147
ARMS-mediated activation	R-HSA-170984	7.131167e-01	0.147
Regulation of signaling by NODAL	R-HSA-1433617	7.131167e-01	0.147
WNT mediated activation of DVL	R-HSA-201688	7.131167e-01	0.147
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.131167e-01	0.147
Regulated proteolysis of p75NTR	R-HSA-193692	7.131167e-01	0.147
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.131167e-01	0.147
Interleukin-1 processing	R-HSA-448706	7.131167e-01	0.147
Lysosomal oligosaccharide catabolism	R-HSA-8853383	7.131167e-01	0.147
Respiratory syncytial virus genome replication	R-HSA-9834752	7.131167e-01	0.147
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.131167e-01	0.147
GP1b-IX-V activation signalling	R-HSA-430116	7.131167e-01	0.147
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.175626e-01	0.144
Hemostasis	R-HSA-109582	7.176205e-01	0.144
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.194269e-01	0.143
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.194269e-01	0.143
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.194269e-01	0.143
Interleukin-2 family signaling	R-HSA-451927	7.194269e-01	0.143
Generation of second messenger molecules	R-HSA-202433	7.194269e-01	0.143
Azathioprine ADME	R-HSA-9748787	7.198268e-01	0.143
DAP12 signaling	R-HSA-2424491	7.223684e-01	0.141
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.223684e-01	0.141
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.223684e-01	0.141
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.229542e-01	0.141
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.249388e-01	0.140
Neuronal System	R-HSA-112316	7.283203e-01	0.138
Protein folding	R-HSA-391251	7.323381e-01	0.135
Co-inhibition by CTLA4	R-HSA-389513	7.329415e-01	0.135
Protein hydroxylation	R-HSA-9629569	7.329415e-01	0.135
The phototransduction cascade	R-HSA-2514856	7.333709e-01	0.135
Heme signaling	R-HSA-9707616	7.343457e-01	0.134
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.343889e-01	0.134
PI Metabolism	R-HSA-1483255	7.363572e-01	0.133
Diseases of carbohydrate metabolism	R-HSA-5663084	7.364554e-01	0.133
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.392082e-01	0.131
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.392082e-01	0.131
Downstream signal transduction	R-HSA-186763	7.392082e-01	0.131
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.403123e-01	0.131
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.414791e-01	0.130
DNA replication initiation	R-HSA-68952	7.414791e-01	0.130
Metabolism of serotonin	R-HSA-380612	7.414791e-01	0.130
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.414791e-01	0.130
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.414791e-01	0.130
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.414791e-01	0.130
PAOs oxidise polyamines to amines	R-HSA-141334	7.414791e-01	0.130
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.414791e-01	0.130
Receptor Mediated Mitophagy	R-HSA-8934903	7.414791e-01	0.130
CASP4 inflammasome assembly	R-HSA-9948001	7.414791e-01	0.130
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.414791e-01	0.130
Unfolded Protein Response (UPR)	R-HSA-381119	7.447766e-01	0.128
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.463730e-01	0.127
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.487416e-01	0.126
HIV Transcription Initiation	R-HSA-167161	7.487416e-01	0.126
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.487416e-01	0.126
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.495140e-01	0.125
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.522907e-01	0.124
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.550112e-01	0.122
Inwardly rectifying K+ channels	R-HSA-1296065	7.552267e-01	0.122
Insulin receptor signalling cascade	R-HSA-74751	7.580019e-01	0.120
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.616273e-01	0.118
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.616273e-01	0.118
Transport to the Golgi and subsequent modification	R-HSA-948021	7.632659e-01	0.117
C-type lectin receptors (CLRs)	R-HSA-5621481	7.647997e-01	0.116
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.670389e-01	0.115
Interleukin-2 signaling	R-HSA-9020558	7.670389e-01	0.115
vRNP Assembly	R-HSA-192905	7.670389e-01	0.115
Chylomicron assembly	R-HSA-8963888	7.670389e-01	0.115
RHOBTB3 ATPase cycle	R-HSA-9706019	7.670389e-01	0.115
Synthesis of PI	R-HSA-1483226	7.670389e-01	0.115
Activated NTRK3 signals through RAS	R-HSA-9034864	7.670389e-01	0.115
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.670389e-01	0.115
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.670389e-01	0.115
Nuclear RNA decay	R-HSA-9930044	7.704421e-01	0.113
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.706191e-01	0.113
Ribavirin ADME	R-HSA-9755088	7.706191e-01	0.113
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.753790e-01	0.110
RNA Polymerase II Promoter Escape	R-HSA-73776	7.756499e-01	0.110
Translation of Structural Proteins	R-HSA-9694635	7.791210e-01	0.108
Pyruvate metabolism	R-HSA-70268	7.792973e-01	0.108
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.853225e-01	0.105
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.876593e-01	0.104
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.876593e-01	0.104
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.876593e-01	0.104
Signaling by KIT in disease	R-HSA-9669938	7.876593e-01	0.104
Fructose metabolism	R-HSA-5652084	7.876593e-01	0.104
LDL clearance	R-HSA-8964038	7.876593e-01	0.104
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.876593e-01	0.104
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.876593e-01	0.104
Proteasome assembly	R-HSA-9907900	7.882252e-01	0.103
Amine ligand-binding receptors	R-HSA-375280	7.882252e-01	0.103
Gap junction trafficking	R-HSA-190828	7.882252e-01	0.103
Transcriptional regulation by RUNX3	R-HSA-8878159	7.890305e-01	0.103
Endosomal/Vacuolar pathway	R-HSA-1236977	7.900730e-01	0.102
Proton-coupled monocarboxylate transport	R-HSA-433692	7.900730e-01	0.102
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.900730e-01	0.102
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.900730e-01	0.102
Activated NTRK2 signals through RAS	R-HSA-9026519	7.900730e-01	0.102
Sodium/Calcium exchangers	R-HSA-425561	7.900730e-01	0.102
Ion homeostasis	R-HSA-5578775	7.939296e-01	0.100
ER-Phagosome pathway	R-HSA-1236974	7.975548e-01	0.098
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.984358e-01	0.098
NPAS4 regulates expression of target genes	R-HSA-9768919	7.985484e-01	0.098
Mitochondrial biogenesis	R-HSA-1592230	7.993019e-01	0.097
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.002303e-01	0.097
Interleukin-20 family signaling	R-HSA-8854691	8.035738e-01	0.095
IRS-mediated signalling	R-HSA-112399	8.046473e-01	0.094
Synthesis of PA	R-HSA-1483166	8.046473e-01	0.094
HCMV Late Events	R-HSA-9610379	8.063593e-01	0.093
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.108308e-01	0.091
Scavenging by Class F Receptors	R-HSA-3000484	8.108308e-01	0.091
MET activates RAS signaling	R-HSA-8851805	8.108308e-01	0.091
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.108308e-01	0.091
Synthesis of GDP-mannose	R-HSA-446205	8.108308e-01	0.091
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.108308e-01	0.091
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.108308e-01	0.091
Signalling to ERKs	R-HSA-187687	8.114859e-01	0.091
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.114859e-01	0.091
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.149182e-01	0.089
Signaling by NTRKs	R-HSA-166520	8.175208e-01	0.088
TRAF6 mediated NF-kB activation	R-HSA-933542	8.184186e-01	0.087
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.184186e-01	0.087
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.184186e-01	0.087
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.184186e-01	0.087
Interferon gamma signaling	R-HSA-877300	8.190726e-01	0.087
GPVI-mediated activation cascade	R-HSA-114604	8.237131e-01	0.084
G1/S-Specific Transcription	R-HSA-69205	8.237131e-01	0.084
Gastrulation	R-HSA-9758941	8.238662e-01	0.084
Peroxisomal protein import	R-HSA-9033241	8.247517e-01	0.084
Triglyceride metabolism	R-HSA-8979227	8.247517e-01	0.084
tRNA processing	R-HSA-72306	8.266793e-01	0.083
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.295372e-01	0.081
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.295372e-01	0.081
Processing of SMDT1	R-HSA-8949664	8.295372e-01	0.081
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.295372e-01	0.081
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.295372e-01	0.081
Platelet Adhesion to exposed collagen	R-HSA-75892	8.295372e-01	0.081
Reversible hydration of carbon dioxide	R-HSA-1475029	8.295372e-01	0.081
Formation of axial mesoderm	R-HSA-9796292	8.295372e-01	0.081
Diseases of nucleotide metabolism	R-HSA-9735804	8.295372e-01	0.081
rRNA modification in the mitochondrion	R-HSA-6793080	8.295372e-01	0.081
Interconversion of polyamines	R-HSA-351200	8.295372e-01	0.081
Maturation of nucleoprotein	R-HSA-9683610	8.295372e-01	0.081
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.295372e-01	0.081
Interleukin-6 signaling	R-HSA-1059683	8.295372e-01	0.081
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.295372e-01	0.081
TGFBR3 expression	R-HSA-9839394	8.322495e-01	0.080
Acyl chain remodelling of PS	R-HSA-1482801	8.322495e-01	0.080
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.322495e-01	0.080
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.322495e-01	0.080
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.331668e-01	0.079
tRNA Aminoacylation	R-HSA-379724	8.341578e-01	0.079
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.371359e-01	0.077
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.451218e-01	0.073
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.451218e-01	0.073
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.451218e-01	0.073
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.451218e-01	0.073
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.451218e-01	0.073
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.451218e-01	0.073
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.461414e-01	0.073
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.463947e-01	0.072
Retrograde neurotrophin signalling	R-HSA-177504	8.463947e-01	0.072
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.463947e-01	0.072
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	8.463947e-01	0.072
Transport of fatty acids	R-HSA-804914	8.463947e-01	0.072
Hydrolysis of LPC	R-HSA-1483115	8.463947e-01	0.072
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.463947e-01	0.072
Physiological factors	R-HSA-5578768	8.463947e-01	0.072
Non-canonical inflammasome activation	R-HSA-9686114	8.463947e-01	0.072
Zinc transporters	R-HSA-435354	8.463947e-01	0.072
P2Y receptors	R-HSA-417957	8.463947e-01	0.072
Signaling by FGFR4 in disease	R-HSA-5655291	8.463947e-01	0.072
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.463947e-01	0.072
PI3K Cascade	R-HSA-109704	8.521999e-01	0.069
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.559657e-01	0.068
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.563962e-01	0.067
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.570898e-01	0.067
RNA Polymerase I Transcription Termination	R-HSA-73863	8.570898e-01	0.067
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.570898e-01	0.067
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.570898e-01	0.067
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.570898e-01	0.067
Maturation of hRSV A proteins	R-HSA-9828806	8.570898e-01	0.067
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.608397e-01	0.065
Lysosphingolipid and LPA receptors	R-HSA-419408	8.615861e-01	0.065
p38MAPK events	R-HSA-171007	8.615861e-01	0.065
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.615861e-01	0.065
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.615861e-01	0.065
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.615861e-01	0.065
Transport and metabolism of PAPS	R-HSA-174362	8.615861e-01	0.065
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.615861e-01	0.065
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.615861e-01	0.065
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.615861e-01	0.065
DNA Damage Reversal	R-HSA-73942	8.615861e-01	0.065
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.682065e-01	0.061
Insulin receptor recycling	R-HSA-77387	8.682065e-01	0.061
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.695238e-01	0.061
Antigen processing-Cross presentation	R-HSA-1236975	8.750251e-01	0.058
Class I peroxisomal membrane protein import	R-HSA-9603798	8.752758e-01	0.058
Atorvastatin ADME	R-HSA-9754706	8.752758e-01	0.058
Activation of the phototransduction cascade	R-HSA-2485179	8.752758e-01	0.058
Fructose catabolism	R-HSA-70350	8.752758e-01	0.058
Killing mechanisms	R-HSA-9664420	8.752758e-01	0.058
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.752758e-01	0.058
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.752758e-01	0.058
Amino acids regulate mTORC1	R-HSA-9639288	8.775105e-01	0.057
Generic Transcription Pathway	R-HSA-212436	8.782592e-01	0.056
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.785231e-01	0.056
ABC transporter disorders	R-HSA-5619084	8.816182e-01	0.055
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.835291e-01	0.054
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.835291e-01	0.054
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.836483e-01	0.054
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.876123e-01	0.052
Heme assimilation	R-HSA-9927020	8.876123e-01	0.052
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.876123e-01	0.052
Passive transport by Aquaporins	R-HSA-432047	8.876123e-01	0.052
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.876123e-01	0.052
Coenzyme A biosynthesis	R-HSA-196783	8.876123e-01	0.052
tRNA modification in the mitochondrion	R-HSA-6787450	8.876123e-01	0.052
Neurotransmitter clearance	R-HSA-112311	8.880891e-01	0.052
Class B/2 (Secretin family receptors)	R-HSA-373080	8.882832e-01	0.051
Cytosolic tRNA aminoacylation	R-HSA-379716	8.916507e-01	0.050
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.983320e-01	0.047
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.983320e-01	0.047
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.987293e-01	0.046
Regulation of NPAS4 gene expression	R-HSA-9768759	8.987293e-01	0.046
Sulfide oxidation to sulfate	R-HSA-1614517	8.987293e-01	0.046
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.987293e-01	0.046
Uptake and function of anthrax toxins	R-HSA-5210891	8.987293e-01	0.046
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.987293e-01	0.046
Signaling by Insulin receptor	R-HSA-74752	9.045797e-01	0.044
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.045797e-01	0.044
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.051573e-01	0.043
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.051573e-01	0.043
DAP12 interactions	R-HSA-2172127	9.061891e-01	0.043
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.087472e-01	0.042
Synaptic adhesion-like molecules	R-HSA-8849932	9.087472e-01	0.042
Apoptotic factor-mediated response	R-HSA-111471	9.087472e-01	0.042
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.087472e-01	0.042
Integrin signaling	R-HSA-354192	9.127483e-01	0.040
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.127483e-01	0.040
Cardiogenesis	R-HSA-9733709	9.127483e-01	0.040
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.170530e-01	0.038
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.177746e-01	0.037
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.177746e-01	0.037
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.177746e-01	0.037
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.177746e-01	0.037
Amine Oxidase reactions	R-HSA-140179	9.177746e-01	0.037
Transport of nucleotide sugars	R-HSA-727802	9.177746e-01	0.037
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.177746e-01	0.037
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.197662e-01	0.036
Acyl chain remodelling of PC	R-HSA-1482788	9.197662e-01	0.036
Effects of PIP2 hydrolysis	R-HSA-114508	9.197662e-01	0.036
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.197662e-01	0.036
Glutamate and glutamine metabolism	R-HSA-8964539	9.197662e-01	0.036
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.224024e-01	0.035
Platelet homeostasis	R-HSA-418346	9.225565e-01	0.035
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.254279e-01	0.034
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	9.259095e-01	0.033
Signaling by NODAL	R-HSA-1181150	9.259095e-01	0.033
Acyl chain remodelling of PI	R-HSA-1482922	9.259095e-01	0.033
Formation of definitive endoderm	R-HSA-9823730	9.259095e-01	0.033
Pregnenolone biosynthesis	R-HSA-196108	9.259095e-01	0.033
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.262501e-01	0.033
Signaling by TGFB family members	R-HSA-9006936	9.268272e-01	0.033
Potassium Channels	R-HSA-1296071	9.272295e-01	0.033
Collagen degradation	R-HSA-1442490	9.274398e-01	0.033
Mitochondrial protein import	R-HSA-1268020	9.321804e-01	0.031
Transferrin endocytosis and recycling	R-HSA-917977	9.322369e-01	0.030
Acyl chain remodelling of PE	R-HSA-1482839	9.322369e-01	0.030
PERK regulates gene expression	R-HSA-381042	9.322369e-01	0.030
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.332400e-01	0.030
Signalling to RAS	R-HSA-167044	9.332400e-01	0.030
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.332400e-01	0.030
ERK/MAPK targets	R-HSA-198753	9.332400e-01	0.030
Zygotic genome activation (ZGA)	R-HSA-9819196	9.332400e-01	0.030
Transcriptional regulation by RUNX2	R-HSA-8878166	9.335092e-01	0.030
Developmental Biology	R-HSA-1266738	9.357655e-01	0.029
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.371807e-01	0.028
Glycosphingolipid transport	R-HSA-9845576	9.377615e-01	0.028
FGFR2 mutant receptor activation	R-HSA-1839126	9.377615e-01	0.028
FOXO-mediated transcription	R-HSA-9614085	9.384373e-01	0.028
Signaling by FGFR2 in disease	R-HSA-5655253	9.398061e-01	0.027
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.398456e-01	0.027
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.398456e-01	0.027
Glutathione synthesis and recycling	R-HSA-174403	9.398456e-01	0.027
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.398456e-01	0.027
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.399190e-01	0.027
Neddylation	R-HSA-8951664	9.424042e-01	0.026
Voltage gated Potassium channels	R-HSA-1296072	9.428567e-01	0.026
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.457979e-01	0.024
RAF-independent MAPK1/3 activation	R-HSA-112409	9.457979e-01	0.024
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.457979e-01	0.024
SLC transporter disorders	R-HSA-5619102	9.464457e-01	0.024
Purine salvage	R-HSA-74217	9.475533e-01	0.023
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.484614e-01	0.023
PKR-mediated signaling	R-HSA-9833482	9.504376e-01	0.022
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.510257e-01	0.022
Regulation of PTEN mRNA translation	R-HSA-8943723	9.511616e-01	0.022
Mitochondrial mRNA modification	R-HSA-9937008	9.511616e-01	0.022
Organic anion transport by SLCO transporters	R-HSA-879518	9.511616e-01	0.022
Carnitine shuttle	R-HSA-200425	9.511616e-01	0.022
Biosynthesis of maresins	R-HSA-9018682	9.511616e-01	0.022
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.518804e-01	0.021
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.518804e-01	0.021
Pentose phosphate pathway	R-HSA-71336	9.518804e-01	0.021
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.530754e-01	0.021
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.548087e-01	0.020
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.558650e-01	0.020
Diseases of Immune System	R-HSA-5260271	9.558650e-01	0.020
rRNA processing in the mitochondrion	R-HSA-8868766	9.558650e-01	0.020
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.558650e-01	0.020
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.559948e-01	0.020
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.559948e-01	0.020
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.559948e-01	0.020
Mitochondrial RNA degradation	R-HSA-9836573	9.559948e-01	0.020
TNFs bind their physiological receptors	R-HSA-5669034	9.559948e-01	0.020
Interleukin-6 family signaling	R-HSA-6783589	9.559948e-01	0.020
Paracetamol ADME	R-HSA-9753281	9.588932e-01	0.018
Aflatoxin activation and detoxification	R-HSA-5423646	9.595326e-01	0.018
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.595326e-01	0.018
Tight junction interactions	R-HSA-420029	9.603499e-01	0.018
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.603499e-01	0.018
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.603499e-01	0.018
Hyaluronan degradation	R-HSA-2160916	9.603499e-01	0.018
Laminin interactions	R-HSA-3000157	9.603499e-01	0.018
COPII-mediated vesicle transport	R-HSA-204005	9.610832e-01	0.017
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.619555e-01	0.017
Scavenging by Class A Receptors	R-HSA-3000480	9.629068e-01	0.016
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.637564e-01	0.016
Leishmania phagocytosis	R-HSA-9664417	9.639180e-01	0.016
Parasite infection	R-HSA-9664407	9.639180e-01	0.016
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.639180e-01	0.016
MET activates PTK2 signaling	R-HSA-8874081	9.642743e-01	0.016
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.642743e-01	0.016
Urea cycle	R-HSA-70635	9.642743e-01	0.016
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.642743e-01	0.016
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.660098e-01	0.015
Protein localization	R-HSA-9609507	9.669672e-01	0.015
Parasitic Infection Pathways	R-HSA-9824443	9.673996e-01	0.014
Leishmania infection	R-HSA-9658195	9.673996e-01	0.014
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.674474e-01	0.014
Cristae formation	R-HSA-8949613	9.678104e-01	0.014
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.678104e-01	0.014
Signaling by FGFR3 in disease	R-HSA-5655332	9.678104e-01	0.014
Disorders of transmembrane transporters	R-HSA-5619115	9.682014e-01	0.014
Cardiac conduction	R-HSA-5576891	9.683988e-01	0.014
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.689223e-01	0.014
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.709967e-01	0.013
Pyrimidine salvage	R-HSA-73614	9.709967e-01	0.013
Prednisone ADME	R-HSA-9757110	9.709967e-01	0.013
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.709967e-01	0.013
Pyroptosis	R-HSA-5620971	9.709967e-01	0.013
Metabolism of polyamines	R-HSA-351202	9.721843e-01	0.012
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.723030e-01	0.012
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.738678e-01	0.011
Downstream signaling of activated FGFR3	R-HSA-5654708	9.738678e-01	0.011
Platelet calcium homeostasis	R-HSA-418360	9.738678e-01	0.011
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.738678e-01	0.011
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.738905e-01	0.011
Degradation of cysteine and homocysteine	R-HSA-1614558	9.738905e-01	0.011
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.761009e-01	0.011
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.761009e-01	0.011
Signaling by TGFBR3	R-HSA-9839373	9.761009e-01	0.011
Signaling by PDGF	R-HSA-186797	9.762627e-01	0.010
Downstream signaling of activated FGFR4	R-HSA-5654716	9.764549e-01	0.010
G alpha (s) signalling events	R-HSA-418555	9.765795e-01	0.010
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.786292e-01	0.009
Cargo concentration in the ER	R-HSA-5694530	9.787859e-01	0.009
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.788799e-01	0.009
Leishmania parasite growth and survival	R-HSA-9664433	9.788799e-01	0.009
Intraflagellar transport	R-HSA-5620924	9.799913e-01	0.009
Metal ion SLC transporters	R-HSA-425410	9.799913e-01	0.009
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.827789e-01	0.008
Recycling of bile acids and salts	R-HSA-159418	9.827789e-01	0.008
Collagen formation	R-HSA-1474290	9.831793e-01	0.007
Kidney development	R-HSA-9830369	9.841148e-01	0.007
Toll-like Receptor Cascades	R-HSA-168898	9.841848e-01	0.007
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.844841e-01	0.007
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.844841e-01	0.007
Heme degradation	R-HSA-189483	9.844841e-01	0.007
Branched-chain amino acid catabolism	R-HSA-70895	9.846995e-01	0.007
G alpha (q) signalling events	R-HSA-416476	9.849027e-01	0.007
Uptake and actions of bacterial toxins	R-HSA-5339562	9.860146e-01	0.006
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.860206e-01	0.006
Hyaluronan metabolism	R-HSA-2142845	9.860206e-01	0.006
RA biosynthesis pathway	R-HSA-5365859	9.860206e-01	0.006
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.864215e-01	0.006
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.864992e-01	0.006
FCERI mediated NF-kB activation	R-HSA-2871837	9.866367e-01	0.006
Nucleotide biosynthesis	R-HSA-8956320	9.872194e-01	0.006
Downstream signaling of activated FGFR2	R-HSA-5654696	9.874050e-01	0.006
Downstream signaling of activated FGFR1	R-HSA-5654687	9.874050e-01	0.006
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.874050e-01	0.006
Metabolism of cofactors	R-HSA-8978934	9.885377e-01	0.005
RUNX2 regulates bone development	R-HSA-8941326	9.886524e-01	0.005
Phospholipid metabolism	R-HSA-1483257	9.890517e-01	0.005
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.894425e-01	0.005
NCAM1 interactions	R-HSA-419037	9.897763e-01	0.004
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.897763e-01	0.004
Collagen chain trimerization	R-HSA-8948216	9.897763e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.897763e-01	0.004
Aspirin ADME	R-HSA-9749641	9.902783e-01	0.004
tRNA processing in the mitochondrion	R-HSA-6785470	9.907890e-01	0.004
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.907890e-01	0.004
ROS and RNS production in phagocytes	R-HSA-1222556	9.910500e-01	0.004
Tryptophan catabolism	R-HSA-71240	9.925235e-01	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	9.925869e-01	0.003
Regulation of beta-cell development	R-HSA-186712	9.925869e-01	0.003
Peptide hormone metabolism	R-HSA-2980736	9.930600e-01	0.003
PPARA activates gene expression	R-HSA-1989781	9.931460e-01	0.003
RAB geranylgeranylation	R-HSA-8873719	9.932346e-01	0.003
Maturation of spike protein	R-HSA-9694548	9.932642e-01	0.003
Cholesterol biosynthesis	R-HSA-191273	9.935861e-01	0.003
Nucleotide salvage	R-HSA-8956321	9.938268e-01	0.003
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.939315e-01	0.003
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.939478e-01	0.003
Mitochondrial protein degradation	R-HSA-9837999	9.944689e-01	0.002
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.952107e-01	0.002
Methylation	R-HSA-156581	9.955626e-01	0.002
Extracellular matrix organization	R-HSA-1474244	9.964142e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.964490e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.964490e-01	0.002
Synthesis of PC	R-HSA-1483191	9.967554e-01	0.001
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.967634e-01	0.001
Sulfur amino acid metabolism	R-HSA-1614635	9.970067e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.970770e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.973122e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.974555e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.975621e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.976278e-01	0.001
Complex IV assembly	R-HSA-9864848	9.978629e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.978772e-01	0.001
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.981495e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.982262e-01	0.001
Glucuronidation	R-HSA-156588	9.984376e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.984987e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.986984e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.987285e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.987285e-01	0.001
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.987321e-01	0.001
Dectin-2 family	R-HSA-5621480	9.988579e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.989410e-01	0.000
Glutathione conjugation	R-HSA-156590	9.991651e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.991651e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.991779e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.991862e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.992703e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.992783e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.993893e-01	0.000
Infectious disease	R-HSA-5663205	9.994025e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.994503e-01	0.000
Xenobiotics	R-HSA-211981	9.994503e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.994503e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.994571e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.995982e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.996104e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.996572e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.997063e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.997355e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.997355e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.997355e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.997355e-01	0.000
FCGR activation	R-HSA-2029481	9.997469e-01	0.000
Purine catabolism	R-HSA-74259	9.997617e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.997657e-01	0.000
Immune System	R-HSA-168256	9.997710e-01	0.000
Transport of small molecules	R-HSA-382551	9.998386e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998458e-01	0.000
Post-translational protein modification	R-HSA-597592	9.998809e-01	0.000
Innate Immune System	R-HSA-168249	9.998836e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998854e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998854e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999070e-01	0.000
Drug ADME	R-HSA-9748784	9.999180e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999740e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999744e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999843e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999905e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999906e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999931e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999939e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999945e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999965e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999973e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999974e-01	0.000
Disease	R-HSA-1643685	9.999977e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999983e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999986e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999986e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999986e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999994e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999994e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999995e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999997e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999997e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999998e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999998e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000