MEKK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43852 T89 Sugiyama CALU sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05976 T146 Sugiyama MYL1 QATYEDFVEGLRVFDKEGNGtVMGAELRHVLATLGEKMKEE
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P08151 S1078 EPSD|PSP GLI1 GLI GLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRSLPGE
P08151 S201 EPSD|PSP GLI1 GLI SELDMLVGKCREEPLEGDMSsPNsTGIQDPLLGMLDGREDL
P08151 S204 EPSD|PSP GLI1 GLI DMLVGKCREEPLEGDMSsPNsTGIQDPLLGMLDGREDLERE
P08151 S243 EPSD|PSP GLI1 GLI REEKREPESVYETDCRWDGCsQEFDSQEQLVHHINSEHIHG
P08151 S968 EPSD|PSP GLI1 GLI YGPGFGPNLPNHKSGSYPTPsPCHENFVVGANRAsHRAAAP
P08151 T1074 EPSD|PSP GLI1 GLI DEPQGLSPPPSHDQRGSsGHtPPPsGPPNMAVGNMsVLLRS
P08590 T147 Sugiyama MYL3 tGtYEDFVEGLRVFDKEGNGtVMGAELRHVLAtLGERLtED
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09972 T125 Sugiyama ALDOC ALDC VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P35579 T1208 Sugiyama MYH9 QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P38117 T172 Sugiyama ETFB FP585 QVTLEGDKLKVEREIDGGLEtLRLKLPAVVTADLRLNEPRy
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P45985 S257 GPS6 MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 LDRSGNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDP
P45985 T261 GPS6 MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 GNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDPSASR
P46734 S218 SIGNOR MAP2K3 MEK3 MKK3 PRKMK3 SKK2 INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P48454 T153 Sugiyama PPP3CC CALNA3 CNA3 KINHPKTLFLLRGNHECRHLtDYFtFKQECRIKYSEQVYDA
P48454 T157 Sugiyama PPP3CC CALNA3 CNA3 PKTLFLLRGNHECRHLtDYFtFKQECRIKYSEQVYDACMET
P52948 S683 Sugiyama NUP98 ADAR2 IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53805 S163 EPSD|PSP RCAN1 ADAPT78 CSP1 DSC1 DSCR1 TLHIGSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVIN
P53805 S167 SIGNOR|EPSD|PSP RCAN1 ADAPT78 CSP1 DSC1 DSCR1 GSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVINYDLL
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63220 S31 Sugiyama RPS21 LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78371 T246 Sugiyama CCT2 99D8.1 CCTB VNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstAKVAE
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z2W4 T294 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 PsPDQIsHRAsLEDAPVDDLtRKFtyLGsQDRARPPsGsSK
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWI9 Y864 Sugiyama MGA KIAA0518 MAD5 FSSNAPTSPVVYQLPTKStsyVRtLDsVLKKQSTISPSTSY
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q99759 S145 Sugiyama MAP3K3 MAPKKK3 MEKK3 RNHNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHL
Q99759 S147 Sugiyama MAP3K3 MAPKKK3 MEKK3 HNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsV
Q99759 S166 Sugiyama MAP3K3 MAPKKK3 MEKK3 QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759 S175 Sugiyama MAP3K3 MAPKKK3 MEKK3 yQPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSY
Q99759 S176 Sugiyama MAP3K3 MAPKKK3 MEKK3 QPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSYT
Q99759 S250 Sugiyama MAP3K3 MAPKKK3 MEKK3 SLDRSADSPSFRKSRMSRAQsFPDNRQEysDREtQLYDKGV
Q99759 S259 Sugiyama MAP3K3 MAPKKK3 MEKK3 SFRKSRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRRY
Q99759 S337 Sugiyama MAP3K3 MAPKKK3 MEKK3 tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99759 S340 Sugiyama MAP3K3 MAPKKK3 MEKK3 ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q99759 S345 Sugiyama MAP3K3 MAPKKK3 MEKK3 AVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPINWRRG
Q99759 S399 Sugiyama MAP3K3 MAPKKK3 MEKK3 CYDVDtGRELASKQVQFDPDsPETSKEVSALECEIQLLKNL
Q99759 S526 GPS6|SIGNOR|EPSD MAP3K3 MAPKKK3 MEKK3 GDFGASKRLQtICMsGTGMRsVtGtPYWMSPEVISGEGYGR
Q99759 T153 Sugiyama MAP3K3 MAPKKK3 MEKK3 HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q99759 T263 Sugiyama MAP3K3 MAPKKK3 MEKK3 SRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRRYHVSV
Q99759 T384 Sugiyama MAP3K3 MAPKKK3 MEKK3 RGKLLGQGAFGRVYLCYDVDtGRELASKQVQFDPDsPETSK
Q99759 T462 Sugiyama MAP3K3 MAPKKK3 MEKK3 FMEYMPGGSVKDQLKAYGALtESVTRKYTRQILEGMSYLHS
Q99759 Y155 Sugiyama MAP3K3 MAPKKK3 MEKK3 GVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPGRs
Q99759 Y258 Sugiyama MAP3K3 MAPKKK3 MEKK3 PSFRKSRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRR
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2U5 S393 Sugiyama MAP3K2 MAPKKK2 MEKK2 CYDVDTGRELAVKQVQFDPDsPETSKEVNALECEIQLLKNL
Q9Y490 T2204 Sugiyama TLN1 KIAA1027 TLN MATAKAVAAGNSCRQEDVIAtANLSRRAIADMLRACKEAAy
Q9Y4G6 T2205 Sugiyama TLN2 KIAA0320 MATAKAVAAGNSCRQEDVIAtANLSRKAVSDMLTACKQASF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic cleavage of cellular proteins R-HSA-111465 1.119952e-08 7.951 0 0
Apoptotic execution phase R-HSA-75153 1.317411e-08 7.880 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.063613e-08 7.685 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.280199e-08 7.642 0 0
Signal Transduction R-HSA-162582 2.864019e-08 7.543 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 9.692616e-07 6.014 0 0
Signaling by ROBO receptors R-HSA-376176 9.540133e-07 6.020 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.234430e-06 5.909 0 0
Axon guidance R-HSA-422475 1.269831e-06 5.896 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.423330e-06 5.616 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.471842e-06 5.607 0 0
Apoptosis R-HSA-109581 2.715779e-06 5.566 0 0
M Phase R-HSA-68886 3.048098e-06 5.516 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.425248e-06 5.465 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.343974e-06 5.362 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.343974e-06 5.362 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.609883e-06 5.336 0 0
Death Receptor Signaling R-HSA-73887 4.379825e-06 5.359 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.379825e-06 5.359 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.917695e-06 5.308 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.630364e-06 5.249 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.750927e-06 5.240 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.838130e-06 5.165 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.316750e-06 5.136 0 0
Nervous system development R-HSA-9675108 6.927558e-06 5.159 0 0
Cell Cycle, Mitotic R-HSA-69278 7.328966e-06 5.135 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.852057e-06 5.105 0 0
Cell Cycle R-HSA-1640170 7.722547e-06 5.112 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.493947e-06 5.071 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.820924e-06 5.008 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.820924e-06 5.008 0 0
Nuclear import of Rev protein R-HSA-180746 1.048508e-05 4.979 0 0
Programmed Cell Death R-HSA-5357801 1.098120e-05 4.959 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.286633e-05 4.891 0 0
p75NTR signals via NF-kB R-HSA-193639 1.723105e-05 4.764 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.905294e-05 4.720 0 0
Signaling by EGFR R-HSA-177929 1.914031e-05 4.718 0 0
Josephin domain DUBs R-HSA-5689877 1.996454e-05 4.700 0 0
Glycolysis R-HSA-70171 2.138154e-05 4.670 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.300408e-05 4.638 0 0
Mitotic Anaphase R-HSA-68882 2.389992e-05 4.622 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.558012e-05 4.592 0 0
Host Interactions of HIV factors R-HSA-162909 2.470089e-05 4.607 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.763809e-05 4.558 0 0
Degradation of CDH1 R-HSA-9766229 3.261315e-05 4.487 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.304940e-05 4.481 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.304940e-05 4.481 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.934215e-05 4.405 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.160495e-05 4.287 0 0
Cell Cycle Checkpoints R-HSA-69620 4.972467e-05 4.303 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.320623e-05 4.274 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.595545e-05 4.252 0 0
HIV Life Cycle R-HSA-162587 5.562797e-05 4.255 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.256928e-05 4.204 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.256928e-05 4.204 0 0
Mitotic Prophase R-HSA-68875 5.749267e-05 4.240 0 0
Regulation of PTEN localization R-HSA-8948747 6.822835e-05 4.166 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.006994e-05 4.154 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.842818e-05 4.053 0 0
Negative regulation of MET activity R-HSA-6807004 9.530985e-05 4.021 0 0
Separation of Sister Chromatids R-HSA-2467813 9.375324e-05 4.028 0 0
Membrane Trafficking R-HSA-199991 9.139610e-05 4.039 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.062509e-04 3.974 0 0
Regulation of CDH1 Function R-HSA-9764561 1.033236e-04 3.986 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.062509e-04 3.974 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.028167e-04 3.988 0 0
Glucose metabolism R-HSA-70326 1.439481e-04 3.842 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.582369e-04 3.801 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.522949e-04 3.817 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.582369e-04 3.801 0 0
EGFR downregulation R-HSA-182971 1.792173e-04 3.747 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.723065e-04 3.764 0 0
Cell-Cell communication R-HSA-1500931 1.971437e-04 3.705 0 0
Cellular response to heat stress R-HSA-3371556 2.007865e-04 3.697 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.242052e-04 3.649 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.020747e-04 3.520 0 0
HIV Infection R-HSA-162906 3.151391e-04 3.501 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.436784e-04 3.464 0 0
Long-term potentiation R-HSA-9620244 3.482956e-04 3.458 0 0
Maturation of protein E R-HSA-9683683 3.703234e-04 3.431 0 0
Maturation of protein E R-HSA-9694493 3.703234e-04 3.431 0 0
Ephrin signaling R-HSA-3928664 4.340203e-04 3.362 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.340203e-04 3.362 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.340203e-04 3.362 0 0
NF-kB is activated and signals survival R-HSA-209560 4.381164e-04 3.358 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.799804e-04 3.319 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.350393e-04 3.272 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.268832e-04 3.278 0 0
Signaling by ALK in cancer R-HSA-9700206 5.268832e-04 3.278 0 0
snRNP Assembly R-HSA-191859 5.561938e-04 3.255 0 0
Metabolism of non-coding RNA R-HSA-194441 5.561938e-04 3.255 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.850751e-04 3.233 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.983623e-04 3.223 0 0
Signaling by ERBB2 R-HSA-1227986 6.222202e-04 3.206 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.917142e-04 3.101 0 0
Post NMDA receptor activation events R-HSA-438064 7.707720e-04 3.113 0 0
MAPK family signaling cascades R-HSA-5683057 7.901890e-04 3.102 0 0
Cell junction organization R-HSA-446728 7.875005e-04 3.104 0 0
tRNA processing in the nucleus R-HSA-6784531 7.737628e-04 3.111 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.476487e-04 3.072 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.862274e-04 3.006 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.905462e-04 3.004 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.905462e-04 3.004 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.750749e-04 3.011 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.531266e-04 3.069 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.247057e-04 3.084 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.531266e-04 3.069 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.333934e-04 3.079 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.905462e-04 3.004 0 0
Orc1 removal from chromatin R-HSA-68949 1.000321e-03 3.000 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.905462e-04 3.004 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.231513e-04 3.085 0 0
G2/M Checkpoints R-HSA-69481 9.975765e-04 3.001 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.602141e-04 3.065 0 0
Signaling by PTK6 R-HSA-8848021 8.602141e-04 3.065 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.109667e-03 2.955 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.170795e-03 2.932 0 0
mTORC1-mediated signalling R-HSA-166208 1.190716e-03 2.924 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.190716e-03 2.924 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.201749e-03 2.920 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.201749e-03 2.920 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.206310e-03 2.919 0 0
Translesion synthesis by REV1 R-HSA-110312 1.249991e-03 2.903 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.249991e-03 2.903 0 0
Signaling by MET R-HSA-6806834 1.256770e-03 2.901 0 0
MTOR signalling R-HSA-165159 1.259197e-03 2.900 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.648221e-03 2.783 0 0
Translesion synthesis by POLI R-HSA-5656121 1.562532e-03 2.806 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.648221e-03 2.783 0 0
TNF signaling R-HSA-75893 1.550995e-03 2.809 0 0
Negative regulation of FLT3 R-HSA-9706369 1.562532e-03 2.806 0 0
NRAGE signals death through JNK R-HSA-193648 1.550995e-03 2.809 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.682523e-03 2.774 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.927096e-03 2.715 0 0
Translesion synthesis by POLK R-HSA-5655862 1.928995e-03 2.715 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.928995e-03 2.715 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.090950e-03 2.680 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.090950e-03 2.680 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.198526e-03 2.658 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.990635e-03 2.701 0 0
Regulation of Apoptosis R-HSA-169911 1.990635e-03 2.701 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.198526e-03 2.658 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.244838e-03 2.649 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.265945e-03 2.645 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.054820e-03 2.687 0 0
Pexophagy R-HSA-9664873 2.198526e-03 2.658 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.267156e-03 2.645 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.267156e-03 2.645 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.354613e-03 2.628 0 0
Glycogen storage diseases R-HSA-3229121 2.354613e-03 2.628 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.552894e-03 2.593 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.572391e-03 2.590 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.691361e-03 2.570 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.844675e-03 2.546 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.863903e-03 2.543 0 0
Ion channel transport R-HSA-983712 2.940649e-03 2.532 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.942064e-03 2.531 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.942064e-03 2.531 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.404498e-03 2.468 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.579295e-03 2.446 0 0
Translesion Synthesis by POLH R-HSA-110320 3.404498e-03 2.468 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.579295e-03 2.446 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.129708e-03 2.504 0 0
Mitotic Prometaphase R-HSA-68877 3.573464e-03 2.447 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.111758e-03 2.507 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.579295e-03 2.446 0 0
Stabilization of p53 R-HSA-69541 3.276704e-03 2.485 0 0
PCP/CE pathway R-HSA-4086400 3.417637e-03 2.466 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.276704e-03 2.485 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.390548e-03 2.470 0 0
NrCAM interactions R-HSA-447038 3.180879e-03 2.497 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.655273e-03 2.437 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.655273e-03 2.437 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.684012e-03 2.434 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.811771e-03 2.419 0 0
Glycogen synthesis R-HSA-3322077 4.039395e-03 2.394 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.201109e-03 2.377 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.544725e-03 2.342 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.583150e-03 2.339 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.583150e-03 2.339 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.583150e-03 2.339 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.597617e-03 2.337 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.597617e-03 2.337 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 4.606996e-03 2.337 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.754651e-03 2.323 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.555495e-03 2.255 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.754651e-03 2.323 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.754651e-03 2.323 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.416744e-03 2.266 0 0
Trafficking of AMPA receptors R-HSA-399719 4.668235e-03 2.331 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.951158e-03 2.305 0 0
Vesicle-mediated transport R-HSA-5653656 4.902356e-03 2.310 0 0
TCR signaling R-HSA-202403 5.330810e-03 2.273 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.555495e-03 2.255 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.754651e-03 2.323 0 0
Stimuli-sensing channels R-HSA-2672351 4.698904e-03 2.328 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.604779e-03 2.251 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.657570e-03 2.247 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.678388e-03 2.246 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.822220e-03 2.235 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.983237e-03 2.223 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.983237e-03 2.223 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.983237e-03 2.223 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.983237e-03 2.223 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.983237e-03 2.223 0 0
Inositol phosphate metabolism R-HSA-1483249 6.028540e-03 2.220 0 0
Signaling by VEGF R-HSA-194138 6.082499e-03 2.216 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.185503e-03 2.209 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.447072e-03 2.191 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.559810e-03 2.183 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.733359e-03 2.172 0 0
RAF activation R-HSA-5673000 7.549387e-03 2.122 0 0
Dual Incision in GG-NER R-HSA-5696400 7.549387e-03 2.122 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.641609e-03 2.117 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.641609e-03 2.117 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.641609e-03 2.117 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.641609e-03 2.117 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.395662e-03 2.076 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.283468e-03 2.082 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.888037e-03 2.162 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.549387e-03 2.122 0 0
Signaling by RAS mutants R-HSA-6802949 7.641609e-03 2.117 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.978764e-03 2.156 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.434409e-03 2.074 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.888037e-03 2.162 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.549387e-03 2.122 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.549387e-03 2.122 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.549387e-03 2.122 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.217269e-03 2.142 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.283468e-03 2.082 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.872034e-03 2.163 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.872034e-03 2.163 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.938784e-03 2.159 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.938784e-03 2.159 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.888037e-03 2.162 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.419681e-03 2.075 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.472702e-03 2.072 0 0
Disinhibition of SNARE formation R-HSA-114516 8.472702e-03 2.072 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.391474e-03 2.027 0 0
Calmodulin induced events R-HSA-111933 9.391474e-03 2.027 0 0
CaM pathway R-HSA-111997 9.391474e-03 2.027 0 0
Cellular Senescence R-HSA-2559583 9.431927e-03 2.025 0 0
Interleukin-7 signaling R-HSA-1266695 9.715970e-03 2.013 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.852160e-03 2.006 0 0
Regulation of BACH1 activity R-HSA-9708530 9.852160e-03 2.006 0 0
S Phase R-HSA-69242 9.993907e-03 2.000 0 0
DNA Damage Bypass R-HSA-73893 1.006584e-02 1.997 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.006584e-02 1.997 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.006584e-02 1.997 0 0
Nucleotide Excision Repair R-HSA-5696398 1.017805e-02 1.992 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.018341e-02 1.992 0 0
G alpha (12/13) signalling events R-HSA-416482 1.018341e-02 1.992 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.042358e-02 1.982 0 0
Degradation of DVL R-HSA-4641258 1.042358e-02 1.982 0 0
Degradation of AXIN R-HSA-4641257 1.042358e-02 1.982 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.042358e-02 1.982 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.042358e-02 1.982 0 0
Interferon Signaling R-HSA-913531 1.048524e-02 1.979 0 0
Type I hemidesmosome assembly R-HSA-446107 1.094409e-02 1.961 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.094409e-02 1.961 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.101953e-02 1.958 0 0
Metalloprotease DUBs R-HSA-5689901 1.101953e-02 1.958 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.101953e-02 1.958 0 0
Deubiquitination R-HSA-5688426 1.130450e-02 1.947 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.134057e-02 1.945 0 0
Synthesis of DNA R-HSA-69239 1.141938e-02 1.942 0 0
Gene Silencing by RNA R-HSA-211000 1.141938e-02 1.942 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.243757e-02 1.905 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.300730e-02 1.886 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.411222e-02 1.850 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.160176e-02 1.935 0 0
Aggrephagy R-HSA-9646399 1.399928e-02 1.854 0 0
Generation of second messenger molecules R-HSA-202433 1.399928e-02 1.854 0 0
Unwinding of DNA R-HSA-176974 1.378966e-02 1.860 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.196594e-02 1.922 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.208184e-02 1.918 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.514040e-02 1.820 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.440981e-02 1.841 0 0
Signaling by Hippo R-HSA-2028269 1.353923e-02 1.868 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.378966e-02 1.860 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.528263e-02 1.816 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.411222e-02 1.850 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.160176e-02 1.935 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.272464e-02 1.895 0 0
Autophagy R-HSA-9612973 1.445415e-02 1.840 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.196594e-02 1.922 0 0
Macroautophagy R-HSA-1632852 1.529583e-02 1.815 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.263075e-02 1.899 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.247950e-02 1.904 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.153368e-02 1.938 0 0
Glycogen metabolism R-HSA-8982491 1.399928e-02 1.854 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.399928e-02 1.854 0 0
DNA Double Strand Break Response R-HSA-5693606 1.347548e-02 1.870 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.160176e-02 1.935 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.485394e-02 1.828 0 0
Signaling by FGFR2 R-HSA-5654738 1.167515e-02 1.933 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.277318e-02 1.894 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.184185e-02 1.927 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.536032e-02 1.814 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.536032e-02 1.814 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.536032e-02 1.814 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.536032e-02 1.814 0 0
Late endosomal microautophagy R-HSA-9615710 1.563373e-02 1.806 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.567087e-02 1.805 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.611381e-02 1.793 0 0
Signaling by FGFR R-HSA-190236 1.615892e-02 1.792 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.652046e-02 1.782 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.662296e-02 1.779 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.668952e-02 1.778 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.681039e-02 1.774 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.681039e-02 1.774 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.681039e-02 1.774 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.681039e-02 1.774 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.701676e-02 1.769 0 0
Signaling by Leptin R-HSA-2586552 1.701676e-02 1.769 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.778095e-02 1.750 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.778095e-02 1.750 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.782757e-02 1.749 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.782757e-02 1.749 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.782757e-02 1.749 0 0
Signaling by FGFR1 R-HSA-5654736 1.782757e-02 1.749 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.800226e-02 1.745 0 0
Regulation of signaling by CBL R-HSA-912631 1.800226e-02 1.745 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.812691e-02 1.742 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.819704e-02 1.740 0 0
Ca-dependent events R-HSA-111996 1.835203e-02 1.736 0 0
MET activates STAT3 R-HSA-8875791 1.836966e-02 1.736 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.848464e-02 1.733 0 0
Cell-cell junction organization R-HSA-421270 1.865478e-02 1.729 0 0
Influenza Infection R-HSA-168255 1.885150e-02 1.725 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.899570e-02 1.721 0 0
Budding and maturation of HIV virion R-HSA-162588 1.933558e-02 1.714 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.933558e-02 1.714 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.998768e-02 1.699 0 0
Signaling by FGFR4 R-HSA-5654743 1.998768e-02 1.699 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.998768e-02 1.699 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.012251e-02 1.696 0 0
Formation of definitive endoderm R-HSA-9823730 2.053831e-02 1.687 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.062990e-02 1.686 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.062990e-02 1.686 0 0
Dual incision in TC-NER R-HSA-6782135 2.065688e-02 1.685 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.129670e-02 1.672 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.138485e-02 1.670 0 0
Adherens junctions interactions R-HSA-418990 2.151233e-02 1.667 0 0
Signaling by ERBB4 R-HSA-1236394 2.160093e-02 1.666 0 0
ER-Phagosome pathway R-HSA-1236974 2.167942e-02 1.664 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.171968e-02 1.663 0 0
G1 Phase R-HSA-69236 2.171968e-02 1.663 0 0
Cyclin D associated events in G1 R-HSA-69231 2.171968e-02 1.663 0 0
Homology Directed Repair R-HSA-5693538 2.249935e-02 1.648 0 0
SLC transporter disorders R-HSA-5619102 2.291532e-02 1.640 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.328320e-02 1.633 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.328320e-02 1.633 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.328320e-02 1.633 0 0
DAG and IP3 signaling R-HSA-1489509 2.355024e-02 1.628 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.355024e-02 1.628 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.355024e-02 1.628 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.355024e-02 1.628 0 0
Signaling by FGFR3 R-HSA-5654741 2.355024e-02 1.628 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.371250e-02 1.625 0 0
Kinesins R-HSA-983189 2.378450e-02 1.624 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.425174e-02 1.615 0 0
Activation of RAC1 R-HSA-428540 2.463100e-02 1.609 0 0
G2/M Transition R-HSA-69275 2.463396e-02 1.608 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.546427e-02 1.594 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.548144e-02 1.594 0 0
IRE1alpha activates chaperones R-HSA-381070 2.561620e-02 1.591 0 0
Developmental Biology R-HSA-1266738 2.586238e-02 1.587 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.624046e-02 1.581 0 0
Assembly Of The HIV Virion R-HSA-175474 2.624046e-02 1.581 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.624046e-02 1.581 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.650692e-02 1.577 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.654769e-02 1.576 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.722341e-02 1.565 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.751528e-02 1.560 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.836177e-02 1.547 0 0
Mitophagy R-HSA-5205647 2.836177e-02 1.547 0 0
MHC class II antigen presentation R-HSA-2132295 2.837244e-02 1.547 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.021841e-02 1.396 0 0
IRS activation R-HSA-74713 3.413078e-02 1.467 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.413078e-02 1.467 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.340968e-02 1.362 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.340968e-02 1.362 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.663249e-02 1.436 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.928383e-02 1.406 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.928383e-02 1.406 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.196751e-02 1.377 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.508172e-02 1.455 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.340968e-02 1.362 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.454950e-02 1.462 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.010601e-02 1.521 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.641147e-02 1.439 0 0
Neurodegenerative Diseases R-HSA-8863678 3.641147e-02 1.439 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.024001e-02 1.395 0 0
Cellular response to hypoxia R-HSA-1234174 3.299125e-02 1.482 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.052774e-02 1.392 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.340968e-02 1.362 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.266420e-02 1.370 0 0
PTEN Regulation R-HSA-6807070 3.011912e-02 1.521 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.671666e-02 1.435 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.678405e-02 1.434 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.288879e-02 1.368 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.906337e-02 1.537 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.967977e-02 1.528 1 0
Regulated Necrosis R-HSA-5218859 3.952149e-02 1.403 0 0
Cellular responses to stress R-HSA-2262752 3.396066e-02 1.469 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.340968e-02 1.362 0 0
Regulation of TP53 Activity R-HSA-5633007 3.515316e-02 1.454 0 0
ABC-family proteins mediated transport R-HSA-382556 4.235062e-02 1.373 0 0
Oncogene Induced Senescence R-HSA-2559585 3.097218e-02 1.509 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.131436e-02 1.384 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.671184e-02 1.435 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.008100e-02 1.522 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.725810e-02 1.429 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.428865e-02 1.354 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.431314e-02 1.353 0 0
Interleukin-1 signaling R-HSA-9020702 4.435100e-02 1.353 1 1
DCC mediated attractive signaling R-HSA-418885 4.447814e-02 1.352 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.447814e-02 1.352 0 0
Signaling by NTRKs R-HSA-166520 4.451457e-02 1.351 0 0
Hedgehog 'on' state R-HSA-5632684 4.684315e-02 1.329 0 0
Interleukin-12 family signaling R-HSA-447115 4.715736e-02 1.326 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.855710e-02 1.314 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.855710e-02 1.314 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.855710e-02 1.314 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.946364e-02 1.306 0 0
Selective autophagy R-HSA-9663891 4.951542e-02 1.305 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.974937e-02 1.303 0 0
FLT3 Signaling R-HSA-9607240 4.974937e-02 1.303 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.095903e-02 1.293 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.142129e-02 1.289 0 0
Interleukin-1 family signaling R-HSA-446652 5.142129e-02 1.289 1 0
HIV elongation arrest and recovery R-HSA-167287 5.304453e-02 1.275 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.304453e-02 1.275 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.304453e-02 1.275 0 0
MAP2K and MAPK activation R-HSA-5674135 5.340766e-02 1.272 0 0
Translation of Structural Proteins R-HSA-9683701 5.340766e-02 1.272 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.350443e-02 1.272 0 0
Ub-specific processing proteases R-HSA-5689880 5.713526e-02 1.243 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.768021e-02 1.239 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.774955e-02 1.238 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.774955e-02 1.238 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.787401e-02 1.238 0 0
Cellular responses to stimuli R-HSA-8953897 5.853548e-02 1.233 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.067239e-02 1.217 0 0
UCH proteinases R-HSA-5689603 6.086202e-02 1.216 0 0
Interleukin-12 signaling R-HSA-9020591 6.086202e-02 1.216 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.089641e-02 1.215 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.133163e-02 1.212 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.264030e-02 1.203 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.267029e-02 1.203 0 0
Specification of primordial germ cells R-HSA-9827857 6.323800e-02 1.199 0 0
Translation of Structural Proteins R-HSA-9694635 6.394289e-02 1.194 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.433460e-02 1.192 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.433460e-02 1.192 0 0
SOS-mediated signalling R-HSA-112412 6.433460e-02 1.192 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.433460e-02 1.192 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.433460e-02 1.192 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.433460e-02 1.192 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.529510e-02 1.185 0 0
Gene expression (Transcription) R-HSA-74160 6.720279e-02 1.173 0 0
Signaling by TGFB family members R-HSA-9006936 6.733940e-02 1.172 0 0
PLC beta mediated events R-HSA-112043 6.754941e-02 1.170 0 0
MAP kinase activation R-HSA-450294 6.754941e-02 1.170 0 0
Downstream signal transduction R-HSA-186763 6.780438e-02 1.169 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.780438e-02 1.169 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.956044e-02 1.158 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.956044e-02 1.158 0 0
GAB1 signalosome R-HSA-180292 7.018263e-02 1.154 0 0
DNA Repair R-HSA-73894 7.077991e-02 1.150 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.126679e-02 1.147 0 0
DNA strand elongation R-HSA-69190 7.314902e-02 1.136 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.374425e-02 1.132 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.397594e-02 1.131 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.417159e-02 1.130 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.509959e-02 1.124 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.509959e-02 1.124 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.582492e-02 1.120 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.582492e-02 1.120 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.582492e-02 1.120 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.582492e-02 1.120 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.582492e-02 1.120 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.582492e-02 1.120 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.619695e-02 1.118 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.745452e-02 1.111 0 0
Specification of the neural plate border R-HSA-9834899 7.745452e-02 1.111 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.745452e-02 1.111 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.870096e-02 1.104 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.882164e-02 1.103 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 7.882164e-02 1.103 0 0
Hereditary fructose intolerance R-HSA-5657560 7.882164e-02 1.103 0 0
Activation and oligomerization of BAK protein R-HSA-111452 7.882164e-02 1.103 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 7.882164e-02 1.103 0 0
Ion transport by P-type ATPases R-HSA-936837 7.904740e-02 1.102 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.904740e-02 1.102 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.310970e-02 1.080 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.325277e-02 1.080 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.378503e-02 1.077 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.378503e-02 1.077 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.378503e-02 1.077 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.438348e-02 1.074 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.445656e-02 1.073 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.504154e-02 1.070 0 0
ARMS-mediated activation R-HSA-170984 8.790493e-02 1.056 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.790493e-02 1.056 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.790493e-02 1.056 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.790493e-02 1.056 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.790493e-02 1.056 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.811123e-02 1.055 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.041182e-02 1.044 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.041182e-02 1.044 0 0
Signaling by NOTCH2 R-HSA-1980145 9.041182e-02 1.044 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.117800e-02 1.040 0 0
L1CAM interactions R-HSA-373760 9.141996e-02 1.039 0 0
G-protein mediated events R-HSA-112040 9.157494e-02 1.038 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 1.158745e-01 0.936 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.158745e-01 0.936 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 1.158745e-01 0.936 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.158745e-01 0.936 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.514391e-01 0.820 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.514391e-01 0.820 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.514391e-01 0.820 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.514391e-01 0.820 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.514391e-01 0.820 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.514391e-01 0.820 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.514391e-01 0.820 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.514391e-01 0.820 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.514391e-01 0.820 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.514391e-01 0.820 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.514391e-01 0.820 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.514391e-01 0.820 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.005088e-01 0.998 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.005088e-01 0.998 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.005088e-01 0.998 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.270460e-01 0.896 0 0
MET activates RAS signaling R-HSA-8851805 1.408684e-01 0.851 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.408684e-01 0.851 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.408684e-01 0.851 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.408684e-01 0.851 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.408684e-01 0.851 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.408684e-01 0.851 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.408684e-01 0.851 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.408684e-01 0.851 0 0
FGFR2 alternative splicing R-HSA-6803529 1.095640e-01 0.960 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.839610e-01 0.735 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.554818e-01 0.808 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.554818e-01 0.808 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.300717e-01 0.886 0 0
Meiotic synapsis R-HSA-1221632 1.089689e-01 0.963 0 0
Translation initiation complex formation R-HSA-72649 1.145281e-01 0.941 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.260425e-01 0.899 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.380652e-01 0.860 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.196234e-01 0.922 0 0
Protein ubiquitination R-HSA-8852135 1.298217e-01 0.887 0 0
Centrosome maturation R-HSA-380287 1.298217e-01 0.887 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.081438e-01 0.966 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.714430e-01 0.766 0 0
Activation of the pre-replicative complex R-HSA-68962 1.854400e-01 0.732 0 0
EPH-Ephrin signaling R-HSA-2682334 1.303893e-01 0.885 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.005088e-01 0.998 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.246713e-01 0.904 0 0
Regulation of CDH11 function R-HSA-9762292 1.005088e-01 0.998 0 0
PI3K/AKT activation R-HSA-198203 1.005088e-01 0.998 0 0
LGI-ADAM interactions R-HSA-5682910 1.135750e-01 0.945 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.303893e-01 0.885 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 1.221437e-01 0.913 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.182802e-01 0.927 0 0
Myogenesis R-HSA-525793 1.458593e-01 0.836 0 0
HCMV Early Events R-HSA-9609690 1.104293e-01 0.957 0 0
p38MAPK events R-HSA-171007 1.839610e-01 0.735 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.458593e-01 0.836 0 0
Peroxisomal protein import R-HSA-9033241 1.442595e-01 0.841 0 0
Signaling by SCF-KIT R-HSA-1433557 1.598515e-01 0.796 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.158745e-01 0.936 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.514391e-01 0.820 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.270460e-01 0.896 0 0
Regulation of KIT signaling R-HSA-1433559 1.693708e-01 0.771 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.839610e-01 0.735 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.839610e-01 0.735 0 0
Signalling to ERKs R-HSA-187687 9.656238e-02 1.015 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.652955e-01 0.782 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.013526e-01 0.994 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.013526e-01 0.994 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.118780e-01 0.951 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.196234e-01 0.922 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.118780e-01 0.951 0 0
Signaling by WNT R-HSA-195721 1.662195e-01 0.779 0 0
Signal attenuation R-HSA-74749 1.005088e-01 0.998 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.500678e-01 0.824 0 0
DNA Replication R-HSA-69306 9.875362e-02 1.005 0 0
Toll-like Receptor Cascades R-HSA-168898 9.694817e-02 1.013 0 0
Circadian clock R-HSA-9909396 1.596754e-01 0.797 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 1.640201e-01 0.785 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.291399e-01 0.889 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.752862e-01 0.756 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.249497e-01 0.903 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.372868e-01 0.862 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.017308e-01 0.993 0 0
Semaphorin interactions R-HSA-373755 1.701768e-01 0.769 0 0
RNA Polymerase II Transcription R-HSA-73857 1.843215e-01 0.734 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.408684e-01 0.851 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.839610e-01 0.735 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.652955e-01 0.782 0 0
Metabolism of RNA R-HSA-8953854 1.358930e-01 0.867 0 0
HCMV Late Events R-HSA-9610379 1.108734e-01 0.955 0 0
Generic Transcription Pathway R-HSA-212436 1.810365e-01 0.742 0 0
Netrin-1 signaling R-HSA-373752 1.676586e-01 0.776 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.005088e-01 0.998 0 0
Adaptive Immune System R-HSA-1280218 1.476366e-01 0.831 0 0
Hedgehog 'off' state R-HSA-5610787 1.755839e-01 0.756 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.673470e-01 0.776 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.635335e-01 0.786 0 0
Signaling by Interleukins R-HSA-449147 1.197770e-01 0.922 1 0
Immune System R-HSA-168256 1.329800e-01 0.876 1 0
Biotin transport and metabolism R-HSA-196780 1.839610e-01 0.735 0 0
Interleukin-17 signaling R-HSA-448424 1.051107e-01 0.978 0 0
Signal regulatory protein family interactions R-HSA-391160 1.693708e-01 0.771 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.839610e-01 0.735 0 0
Signaling by PDGF R-HSA-186797 1.635335e-01 0.786 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.797550e-02 1.009 0 0
G1/S Transition R-HSA-69206 1.268177e-01 0.897 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.547240e-01 0.810 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.161378e-01 0.935 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.182802e-01 0.927 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.035452e-01 0.985 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.161378e-01 0.935 0 0
Interleukin-37 signaling R-HSA-9008059 1.854400e-01 0.732 0 0
ABC transporter disorders R-HSA-5619084 1.458693e-01 0.836 0 0
RET signaling R-HSA-8853659 1.029036e-01 0.988 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 1.196234e-01 0.922 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.288923e-01 0.890 0 0
Signaling by NOTCH3 R-HSA-9012852 1.202203e-01 0.920 0 0
Growth hormone receptor signaling R-HSA-982772 1.182802e-01 0.927 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 1.298217e-01 0.887 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.051107e-01 0.978 0 0
Signaling by NOTCH4 R-HSA-9013694 1.246713e-01 0.904 0 0
RAS processing R-HSA-9648002 1.230201e-01 0.910 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 1.303893e-01 0.885 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.305334e-01 0.884 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.230201e-01 0.910 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.521830e-01 0.818 0 0
FLT3 signaling in disease R-HSA-9682385 1.029036e-01 0.988 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.855752e-01 0.731 0 0
MET interacts with TNS proteins R-HSA-8875513 1.855752e-01 0.731 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.855752e-01 0.731 0 0
MET activates PTPN11 R-HSA-8865999 1.855752e-01 0.731 0 0
Signalling to STAT3 R-HSA-198745 1.855752e-01 0.731 0 0
Type II Na+/Pi cotransporters R-HSA-427589 1.855752e-01 0.731 0 0
Ribosome-associated quality control R-HSA-9948299 1.914411e-01 0.718 0 0
Recycling pathway of L1 R-HSA-437239 1.918451e-01 0.717 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.918451e-01 0.717 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.919250e-01 0.717 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.948999e-01 0.710 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.975715e-01 0.704 0 0
Opioid Signalling R-HSA-111885 1.975715e-01 0.704 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.987227e-01 0.702 0 0
Prolonged ERK activation events R-HSA-169893 1.987227e-01 0.702 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.987227e-01 0.702 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.987227e-01 0.702 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.001404e-01 0.699 0 0
NGF-stimulated transcription R-HSA-9031628 2.001404e-01 0.699 0 0
Pyruvate metabolism R-HSA-70268 2.051724e-01 0.688 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.052737e-01 0.688 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.085411e-01 0.681 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.089530e-01 0.680 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.129412e-01 0.672 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.136185e-01 0.670 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.136185e-01 0.670 0 0
mRNA Splicing R-HSA-72172 2.150076e-01 0.668 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.167441e-01 0.664 0 0
Integrin signaling R-HSA-354192 2.167441e-01 0.664 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.167441e-01 0.664 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.167441e-01 0.664 0 0
Nucleotide catabolism defects R-HSA-9735786 2.183400e-01 0.661 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.183400e-01 0.661 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.183400e-01 0.661 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.183400e-01 0.661 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.183400e-01 0.661 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.183400e-01 0.661 0 0
Regulation of gap junction activity R-HSA-191650 2.183400e-01 0.661 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.183400e-01 0.661 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.193556e-01 0.659 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.244559e-01 0.649 0 0
Downstream TCR signaling R-HSA-202424 2.244559e-01 0.649 0 0
HSF1-dependent transactivation R-HSA-3371571 2.256322e-01 0.647 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.264678e-01 0.645 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.264678e-01 0.645 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.286138e-01 0.641 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.325431e-01 0.633 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.341485e-01 0.631 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.341485e-01 0.631 0 0
mRNA 3'-end processing R-HSA-72187 2.343093e-01 0.630 0 0
Neurexins and neuroligins R-HSA-6794361 2.343093e-01 0.630 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.384164e-01 0.623 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.384164e-01 0.623 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.410269e-01 0.618 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.436765e-01 0.613 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.436765e-01 0.613 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.436765e-01 0.613 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.436765e-01 0.613 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.486530e-01 0.604 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.487885e-01 0.604 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.490366e-01 0.604 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.492119e-01 0.603 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 2.497886e-01 0.602 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.497886e-01 0.602 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.497886e-01 0.602 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.497886e-01 0.602 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.497886e-01 0.602 0 0
Reelin signalling pathway R-HSA-8866376 2.497886e-01 0.602 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.497886e-01 0.602 0 0
Suppression of autophagy R-HSA-9636569 2.497886e-01 0.602 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.497886e-01 0.602 0 0
Gastrulation R-HSA-9758941 2.514527e-01 0.600 0 0
tRNA processing R-HSA-72306 2.529713e-01 0.597 0 0
Reproduction R-HSA-1474165 2.544302e-01 0.594 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.578079e-01 0.589 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.579270e-01 0.589 0 0
Rap1 signalling R-HSA-392517 2.587771e-01 0.587 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 2.587771e-01 0.587 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 2.587771e-01 0.587 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.587771e-01 0.587 0 0
RUNX2 regulates bone development R-HSA-8941326 2.599618e-01 0.585 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.620254e-01 0.582 0 0
Signaling by NOTCH1 R-HSA-1980143 2.645134e-01 0.578 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.646351e-01 0.577 0 0
Ion homeostasis R-HSA-5578775 2.697413e-01 0.569 0 0
Nephrin family interactions R-HSA-373753 2.738882e-01 0.562 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.738882e-01 0.562 0 0
Developmental Cell Lineages R-HSA-9734767 2.774694e-01 0.557 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.780605e-01 0.556 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.784241e-01 0.555 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.799738e-01 0.553 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.799738e-01 0.553 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.799738e-01 0.553 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.799738e-01 0.553 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 2.799738e-01 0.553 0 0
Signaling by MAPK mutants R-HSA-9652817 2.799738e-01 0.553 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 2.799738e-01 0.553 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.799738e-01 0.553 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.799738e-01 0.553 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.799738e-01 0.553 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 2.799738e-01 0.553 0 0
Interleukin-10 signaling R-HSA-6783783 2.800203e-01 0.553 0 0
MET promotes cell motility R-HSA-8875878 2.819832e-01 0.550 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.878408e-01 0.541 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.880360e-01 0.541 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.880360e-01 0.541 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.889845e-01 0.539 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.889845e-01 0.539 0 0
Signalling to RAS R-HSA-167044 2.889845e-01 0.539 0 0
Co-inhibition by PD-1 R-HSA-389948 2.919512e-01 0.535 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.930569e-01 0.533 0 0
Signaling by ALK R-HSA-201556 2.930569e-01 0.533 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.930569e-01 0.533 0 0
HATs acetylate histones R-HSA-3214847 2.994013e-01 0.524 0 0
Cellular response to starvation R-HSA-9711097 3.000371e-01 0.523 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.008596e-01 0.522 0 0
Amyloid fiber formation R-HSA-977225 3.035959e-01 0.518 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.040429e-01 0.517 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.040429e-01 0.517 0 0
HIV Transcription Elongation R-HSA-167169 3.041584e-01 0.517 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.041584e-01 0.517 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.060247e-01 0.514 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.060247e-01 0.514 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.060247e-01 0.514 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.060247e-01 0.514 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.060247e-01 0.514 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.060247e-01 0.514 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.089462e-01 0.510 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.089462e-01 0.510 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.089462e-01 0.510 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.089462e-01 0.510 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 3.089462e-01 0.510 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.089462e-01 0.510 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 3.089462e-01 0.510 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.089462e-01 0.510 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.089462e-01 0.510 0 0
MET Receptor Activation R-HSA-6806942 3.089462e-01 0.510 0 0
CREB phosphorylation R-HSA-199920 3.089462e-01 0.510 0 0
Nef and signal transduction R-HSA-164944 3.089462e-01 0.510 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.089462e-01 0.510 0 0
Chromatin organization R-HSA-4839726 3.150131e-01 0.502 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.151824e-01 0.501 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.152774e-01 0.501 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.152774e-01 0.501 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.190419e-01 0.496 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.190419e-01 0.496 0 0
Signaling by KIT in disease R-HSA-9669938 3.190419e-01 0.496 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.190419e-01 0.496 0 0
HCMV Infection R-HSA-9609646 3.195616e-01 0.495 0 0
PI Metabolism R-HSA-1483255 3.206638e-01 0.494 0 0
Neutrophil degranulation R-HSA-6798695 3.228474e-01 0.491 0 0
Intra-Golgi traffic R-HSA-6811438 3.264040e-01 0.486 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.335611e-01 0.477 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.339620e-01 0.476 0 0
Carnitine shuttle R-HSA-200425 3.339620e-01 0.476 0 0
Syndecan interactions R-HSA-3000170 3.339620e-01 0.476 0 0
Meiosis R-HSA-1500620 3.354532e-01 0.474 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.367545e-01 0.473 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.367545e-01 0.473 0 0
Recycling of eIF2:GDP R-HSA-72731 3.367545e-01 0.473 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.367545e-01 0.473 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.367545e-01 0.473 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.367545e-01 0.473 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.367545e-01 0.473 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.367545e-01 0.473 0 0
Netrin mediated repulsion signals R-HSA-418886 3.367545e-01 0.473 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.367545e-01 0.473 0 0
Transmission across Chemical Synapses R-HSA-112315 3.375364e-01 0.472 0 0
RSV-host interactions R-HSA-9833110 3.421371e-01 0.466 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.487854e-01 0.457 0 0
Deadenylation of mRNA R-HSA-429947 3.487854e-01 0.457 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.487854e-01 0.457 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.487854e-01 0.457 0 0
Chromatin modifying enzymes R-HSA-3247509 3.520491e-01 0.453 0 0
Cilium Assembly R-HSA-5617833 3.569578e-01 0.447 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.597366e-01 0.444 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.634454e-01 0.440 0 0
MET receptor recycling R-HSA-8875656 3.634454e-01 0.440 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.634454e-01 0.440 0 0
Interleukin-23 signaling R-HSA-9020933 3.634454e-01 0.440 0 0
Formation of annular gap junctions R-HSA-196025 3.634454e-01 0.440 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.634454e-01 0.440 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.634454e-01 0.440 0 0
Interleukin-9 signaling R-HSA-8985947 3.634454e-01 0.440 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.634454e-01 0.440 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.634454e-01 0.440 0 0
Tight junction interactions R-HSA-420029 3.634957e-01 0.440 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.634957e-01 0.440 0 0
TGFBR3 expression R-HSA-9839394 3.634957e-01 0.440 0 0
Platelet degranulation R-HSA-114608 3.661067e-01 0.436 0 0
Peptide chain elongation R-HSA-156902 3.675727e-01 0.435 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.708027e-01 0.431 0 0
Somitogenesis R-HSA-9824272 3.708027e-01 0.431 0 0
MET activates PTK2 signaling R-HSA-8874081 3.780779e-01 0.422 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 3.780779e-01 0.422 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.780779e-01 0.422 0 0
Sphingolipid catabolism R-HSA-9845614 3.780779e-01 0.422 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.780779e-01 0.422 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.780779e-01 0.422 0 0
Transcription of the HIV genome R-HSA-167172 3.796206e-01 0.421 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.818327e-01 0.418 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.818327e-01 0.418 0 0
Signaling by TGFBR3 R-HSA-9839373 3.818327e-01 0.418 0 0
ALK mutants bind TKIs R-HSA-9700645 3.890637e-01 0.410 0 0
Gap junction degradation R-HSA-190873 3.890637e-01 0.410 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.890637e-01 0.410 0 0
Calcineurin activates NFAT R-HSA-2025928 3.890637e-01 0.410 0 0
Lipophagy R-HSA-9613354 3.890637e-01 0.410 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.890637e-01 0.410 0 0
Interleukin-21 signaling R-HSA-9020958 3.890637e-01 0.410 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.890637e-01 0.410 0 0
Regulation of signaling by NODAL R-HSA-1433617 3.890637e-01 0.410 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.890637e-01 0.410 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.890637e-01 0.410 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.890637e-01 0.410 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.890637e-01 0.410 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.890637e-01 0.410 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.925187e-01 0.406 0 0
Insulin processing R-HSA-264876 3.925187e-01 0.406 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.925187e-01 0.406 0 0
Cellular response to chemical stress R-HSA-9711123 4.034869e-01 0.394 0 0
Gluconeogenesis R-HSA-70263 4.037548e-01 0.394 0 0
Co-stimulation by CD28 R-HSA-389356 4.037548e-01 0.394 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.068058e-01 0.391 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.068058e-01 0.391 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.077446e-01 0.390 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.136526e-01 0.383 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.136526e-01 0.383 0 0
Binding and entry of HIV virion R-HSA-173107 4.136526e-01 0.383 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.136526e-01 0.383 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.136526e-01 0.383 0 0
Interleukin-27 signaling R-HSA-9020956 4.136526e-01 0.383 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.136526e-01 0.383 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.136526e-01 0.383 0 0
SARS-CoV Infections R-HSA-9679506 4.165787e-01 0.380 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.209282e-01 0.376 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.209282e-01 0.376 0 0
Azathioprine ADME R-HSA-9748787 4.254466e-01 0.371 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.317024e-01 0.365 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.348761e-01 0.362 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.348761e-01 0.362 0 0
Interferon alpha/beta signaling R-HSA-909733 4.359019e-01 0.361 0 0
Signaling by APC mutants R-HSA-4839744 4.372532e-01 0.359 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.372532e-01 0.359 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.372532e-01 0.359 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.372532e-01 0.359 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.372532e-01 0.359 0 0
Bicarbonate transporters R-HSA-425381 4.372532e-01 0.359 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.372532e-01 0.359 0 0
Suppression of apoptosis R-HSA-9635465 4.372532e-01 0.359 0 0
PECAM1 interactions R-HSA-210990 4.372532e-01 0.359 0 0
Iron uptake and transport R-HSA-917937 4.434033e-01 0.353 0 0
Neuronal System R-HSA-112316 4.474493e-01 0.349 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.486406e-01 0.348 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 4.486406e-01 0.348 0 0
Cargo concentration in the ER R-HSA-5694530 4.486406e-01 0.348 0 0
Signaling by Hedgehog R-HSA-5358351 4.519922e-01 0.345 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.574431e-01 0.340 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.599053e-01 0.337 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.599053e-01 0.337 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.599053e-01 0.337 0 0
Signaling by AXIN mutants R-HSA-4839735 4.599053e-01 0.337 0 0
Signaling by WNT in cancer R-HSA-4791275 4.622139e-01 0.335 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.622139e-01 0.335 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.622139e-01 0.335 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.650740e-01 0.332 0 0
Leishmania phagocytosis R-HSA-9664417 4.650740e-01 0.332 0 0
Parasite infection R-HSA-9664407 4.650740e-01 0.332 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.755891e-01 0.323 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.755891e-01 0.323 0 0
Cardiogenesis R-HSA-9733709 4.755891e-01 0.323 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.769225e-01 0.322 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.785721e-01 0.320 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.816469e-01 0.317 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.816469e-01 0.317 0 0
Maple Syrup Urine Disease R-HSA-9865114 4.816469e-01 0.317 0 0
Polymerase switching R-HSA-69091 4.816469e-01 0.317 0 0
Leading Strand Synthesis R-HSA-69109 4.816469e-01 0.317 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.816469e-01 0.317 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.816469e-01 0.317 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.816469e-01 0.317 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.816469e-01 0.317 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.816469e-01 0.317 0 0
Signaling by LTK R-HSA-9842663 4.816469e-01 0.317 0 0
Interleukin-15 signaling R-HSA-8983432 4.816469e-01 0.317 0 0
Disorders of Nervous System Development R-HSA-9697154 4.816469e-01 0.317 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.816469e-01 0.317 0 0
Pervasive developmental disorders R-HSA-9005895 4.816469e-01 0.317 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 4.816469e-01 0.317 0 0
Repression of WNT target genes R-HSA-4641265 4.816469e-01 0.317 0 0
OAS antiviral response R-HSA-8983711 4.816469e-01 0.317 0 0
Interleukin-35 Signalling R-HSA-8984722 4.816469e-01 0.317 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.816469e-01 0.317 0 0
FCERI mediated NF-kB activation R-HSA-2871837 4.974329e-01 0.303 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.017220e-01 0.300 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.017220e-01 0.300 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 5.017220e-01 0.300 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.017220e-01 0.300 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.017220e-01 0.300 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.017220e-01 0.300 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.025145e-01 0.299 0 0
Frs2-mediated activation R-HSA-170968 5.025145e-01 0.299 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.025145e-01 0.299 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.025145e-01 0.299 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.025145e-01 0.299 0 0
Interleukin-6 signaling R-HSA-1059683 5.025145e-01 0.299 0 0
Formation of axial mesoderm R-HSA-9796292 5.025145e-01 0.299 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.025145e-01 0.299 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.025145e-01 0.299 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.025145e-01 0.299 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.025145e-01 0.299 0 0
Maturation of nucleoprotein R-HSA-9683610 5.025145e-01 0.299 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.089786e-01 0.293 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.134397e-01 0.290 0 0
PERK regulates gene expression R-HSA-381042 5.144699e-01 0.289 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.144699e-01 0.289 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.189776e-01 0.285 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.189776e-01 0.285 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 5.225433e-01 0.282 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.225433e-01 0.282 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.225433e-01 0.282 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.225433e-01 0.282 0 0
cGMP effects R-HSA-418457 5.225433e-01 0.282 0 0
HDL assembly R-HSA-8963896 5.225433e-01 0.282 0 0
Zinc transporters R-HSA-435354 5.225433e-01 0.282 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.270002e-01 0.278 0 0
RNA Polymerase III Transcription R-HSA-74158 5.270002e-01 0.278 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.270002e-01 0.278 0 0
HSF1 activation R-HSA-3371511 5.270002e-01 0.278 0 0
GPVI-mediated activation cascade R-HSA-114604 5.270002e-01 0.278 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.288655e-01 0.277 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.288655e-01 0.277 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.386391e-01 0.269 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.417669e-01 0.266 0 0
Erythropoietin activates RAS R-HSA-9027284 5.417669e-01 0.266 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.417669e-01 0.266 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.417669e-01 0.266 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.417669e-01 0.266 0 0
Protein methylation R-HSA-8876725 5.417669e-01 0.266 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.417669e-01 0.266 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.417669e-01 0.266 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.417669e-01 0.266 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.417669e-01 0.266 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.417669e-01 0.266 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.482956e-01 0.261 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.513960e-01 0.259 0 0
Protein localization R-HSA-9609507 5.539624e-01 0.257 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.547198e-01 0.256 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.554038e-01 0.255 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.601075e-01 0.252 0 0
Phosphorylation of the APC/C R-HSA-176412 5.602176e-01 0.252 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.602176e-01 0.252 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.602176e-01 0.252 0 0
Fructose catabolism R-HSA-70350 5.602176e-01 0.252 0 0
Differentiation of T cells R-HSA-9945266 5.602176e-01 0.252 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.602176e-01 0.252 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.632570e-01 0.249 0 0
Pentose phosphate pathway R-HSA-71336 5.632570e-01 0.249 0 0
Diseases of programmed cell death R-HSA-9645723 5.635248e-01 0.249 0 0
Diseases of Immune System R-HSA-5260271 5.748912e-01 0.240 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.748912e-01 0.240 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 5.748912e-01 0.240 0 0
Translation R-HSA-72766 5.767436e-01 0.239 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.779265e-01 0.238 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.779265e-01 0.238 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.779265e-01 0.238 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.779265e-01 0.238 0 0
Heme assimilation R-HSA-9927020 5.779265e-01 0.238 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.779265e-01 0.238 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.779265e-01 0.238 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.779265e-01 0.238 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.779265e-01 0.238 0 0
Disorders of Developmental Biology R-HSA-9675151 5.779265e-01 0.238 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.779265e-01 0.238 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.857031e-01 0.232 0 0
Maturation of spike protein R-HSA-9694548 5.862978e-01 0.232 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.873908e-01 0.231 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.949234e-01 0.226 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.949234e-01 0.226 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.949234e-01 0.226 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.949234e-01 0.226 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.949234e-01 0.226 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.951751e-01 0.225 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.974762e-01 0.224 0 0
Hemostasis R-HSA-109582 5.989013e-01 0.223 0 0
Protein folding R-HSA-391251 6.028715e-01 0.220 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.037505e-01 0.219 0 0
Peptide ligand-binding receptors R-HSA-375276 6.044980e-01 0.219 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.084262e-01 0.216 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.112367e-01 0.214 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.112367e-01 0.214 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.112367e-01 0.214 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.112367e-01 0.214 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.112367e-01 0.214 0 0
Tie2 Signaling R-HSA-210993 6.112367e-01 0.214 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.268941e-01 0.203 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.268941e-01 0.203 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.268941e-01 0.203 0 0
The NLRP3 inflammasome R-HSA-844456 6.268941e-01 0.203 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.268941e-01 0.203 0 0
Maturation of nucleoprotein R-HSA-9694631 6.268941e-01 0.203 0 0
Other interleukin signaling R-HSA-449836 6.268941e-01 0.203 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.295869e-01 0.201 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.295869e-01 0.201 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.295869e-01 0.201 0 0
Proteasome assembly R-HSA-9907900 6.296426e-01 0.201 0 0
Surfactant metabolism R-HSA-5683826 6.296426e-01 0.201 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.299349e-01 0.201 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.327551e-01 0.199 0 0
Eukaryotic Translation Termination R-HSA-72764 6.327551e-01 0.199 0 0
Nucleosome assembly R-HSA-774815 6.399105e-01 0.194 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.399105e-01 0.194 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.419217e-01 0.193 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.419217e-01 0.193 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.419217e-01 0.193 0 0
Signaling by NODAL R-HSA-1181150 6.419217e-01 0.193 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.419217e-01 0.193 0 0
Synthesis of Ketone Bodies R-HSA-77111 6.419217e-01 0.193 0 0
Protein hydroxylation R-HSA-9629569 6.419217e-01 0.193 0 0
Signal transduction by L1 R-HSA-445144 6.419217e-01 0.193 0 0
Ca2+ pathway R-HSA-4086398 6.462156e-01 0.190 0 0
Diseases of DNA repair R-HSA-9675135 6.499530e-01 0.187 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.541946e-01 0.184 0 0
Signaling by FGFR in disease R-HSA-1226099 6.543292e-01 0.184 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.563450e-01 0.183 0 0
Lagging Strand Synthesis R-HSA-69186 6.563450e-01 0.183 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.563450e-01 0.183 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.563450e-01 0.183 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.597718e-01 0.181 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.623086e-01 0.179 0 0
Formation of the cornified envelope R-HSA-6809371 6.686224e-01 0.175 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.701882e-01 0.174 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.701882e-01 0.174 0 0
Ribavirin ADME R-HSA-9755088 6.701882e-01 0.174 0 0
Selenocysteine synthesis R-HSA-2408557 6.747802e-01 0.171 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.784890e-01 0.168 0 0
Gap junction trafficking and regulation R-HSA-157858 6.787448e-01 0.168 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.834745e-01 0.165 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.834745e-01 0.165 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.834745e-01 0.165 0 0
Fructose metabolism R-HSA-5652084 6.834745e-01 0.165 0 0
PI3K Cascade R-HSA-109704 6.879033e-01 0.162 0 0
Viral mRNA Translation R-HSA-192823 6.880242e-01 0.162 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.962264e-01 0.157 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.962264e-01 0.157 0 0
Interleukin-20 family signaling R-HSA-8854691 6.962264e-01 0.157 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.962264e-01 0.157 0 0
Ketone body metabolism R-HSA-74182 6.962264e-01 0.157 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.962264e-01 0.157 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.962264e-01 0.157 0 0
Branched-chain amino acid catabolism R-HSA-70895 6.968461e-01 0.157 0 0
PKR-mediated signaling R-HSA-9833482 7.001933e-01 0.155 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.055758e-01 0.151 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.055758e-01 0.151 0 0
rRNA processing R-HSA-72312 7.065072e-01 0.151 0 0
GPCR downstream signalling R-HSA-388396 7.067385e-01 0.151 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.084653e-01 0.150 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.084653e-01 0.150 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.084653e-01 0.150 0 0
Interleukin-6 family signaling R-HSA-6783589 7.084653e-01 0.150 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.084653e-01 0.150 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.084653e-01 0.150 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.084653e-01 0.150 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.140949e-01 0.146 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.140949e-01 0.146 0 0
Smooth Muscle Contraction R-HSA-445355 7.140949e-01 0.146 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.194471e-01 0.143 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.202118e-01 0.143 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.202118e-01 0.143 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.202118e-01 0.143 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.202118e-01 0.143 0 0
HDMs demethylate histones R-HSA-3214842 7.202118e-01 0.143 0 0
Formation of the nephric duct R-HSA-9830364 7.202118e-01 0.143 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.202118e-01 0.143 0 0
Laminin interactions R-HSA-3000157 7.202118e-01 0.143 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.202118e-01 0.143 0 0
Cardiac conduction R-HSA-5576891 7.207152e-01 0.142 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.213261e-01 0.142 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.224063e-01 0.141 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.305129e-01 0.136 0 0
G alpha (z) signalling events R-HSA-418597 7.305129e-01 0.136 0 0
Paracetamol ADME R-HSA-9753281 7.305129e-01 0.136 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.314857e-01 0.136 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.314857e-01 0.136 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.314857e-01 0.136 0 0
TRP channels R-HSA-3295583 7.314857e-01 0.136 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.314857e-01 0.136 0 0
Muscle contraction R-HSA-397014 7.356226e-01 0.133 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.384177e-01 0.132 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.389530e-01 0.131 0 0
Signaling by NOTCH R-HSA-157118 7.397431e-01 0.131 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.412814e-01 0.130 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.423059e-01 0.129 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.423059e-01 0.129 0 0
Signaling by BMP R-HSA-201451 7.423059e-01 0.129 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.423059e-01 0.129 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.423059e-01 0.129 0 0
IRS-mediated signalling R-HSA-112399 7.461238e-01 0.127 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.476758e-01 0.126 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.484717e-01 0.126 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.484717e-01 0.126 0 0
Innate Immune System R-HSA-168249 7.516123e-01 0.124 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.520443e-01 0.124 0 0
Integration of energy metabolism R-HSA-163685 7.520443e-01 0.124 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.526908e-01 0.123 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.526908e-01 0.123 0 0
Telomere Extension By Telomerase R-HSA-171319 7.526908e-01 0.123 0 0
Inflammasomes R-HSA-622312 7.526908e-01 0.123 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.526908e-01 0.123 0 0
Pyroptosis R-HSA-5620971 7.526908e-01 0.123 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.594191e-01 0.120 0 0
Extension of Telomeres R-HSA-180786 7.609525e-01 0.119 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.623756e-01 0.118 0 0
Signaling by Erythropoietin R-HSA-9006335 7.626578e-01 0.118 0 0
mRNA Capping R-HSA-72086 7.626578e-01 0.118 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.626578e-01 0.118 0 0
Platelet calcium homeostasis R-HSA-418360 7.626578e-01 0.118 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.626578e-01 0.118 0 0
DARPP-32 events R-HSA-180024 7.626578e-01 0.118 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.626578e-01 0.118 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.647528e-01 0.116 0 0
tRNA Aminoacylation R-HSA-379724 7.680817e-01 0.115 0 0
Metabolism of polyamines R-HSA-351202 7.680817e-01 0.115 0 0
Neddylation R-HSA-8951664 7.719785e-01 0.112 0 0
DAP12 signaling R-HSA-2424491 7.722237e-01 0.112 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.722237e-01 0.112 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.722237e-01 0.112 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.722237e-01 0.112 0 0
Activation of BH3-only proteins R-HSA-114452 7.722237e-01 0.112 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.750252e-01 0.111 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.814046e-01 0.107 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.814046e-01 0.107 0 0
Rab regulation of trafficking R-HSA-9007101 7.851689e-01 0.105 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.883686e-01 0.103 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.902160e-01 0.102 0 0
G0 and Early G1 R-HSA-1538133 7.902160e-01 0.102 0 0
IGF1R signaling cascade R-HSA-2428924 7.947754e-01 0.100 0 0
Insulin receptor signalling cascade R-HSA-74751 7.947754e-01 0.100 0 0
G-protein beta:gamma signalling R-HSA-397795 7.986727e-01 0.098 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.986727e-01 0.098 0 0
Collagen formation R-HSA-1474290 7.996633e-01 0.097 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.010102e-01 0.096 0 0
Chromosome Maintenance R-HSA-73886 8.041495e-01 0.095 0 0
Striated Muscle Contraction R-HSA-390522 8.067891e-01 0.093 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.067891e-01 0.093 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.067891e-01 0.093 0 0
Heme degradation R-HSA-189483 8.067891e-01 0.093 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.145787e-01 0.089 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.145787e-01 0.089 0 0
Hyaluronan metabolism R-HSA-2142845 8.145787e-01 0.089 0 0
Signal amplification R-HSA-392518 8.145787e-01 0.089 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.187169e-01 0.087 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.187169e-01 0.087 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.187169e-01 0.087 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.220547e-01 0.085 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.220547e-01 0.085 0 0
ESR-mediated signaling R-HSA-8939211 8.274113e-01 0.082 0 0
Signaling by GPCR R-HSA-372790 8.282643e-01 0.082 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.292297e-01 0.081 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.292297e-01 0.081 0 0
COPII-mediated vesicle transport R-HSA-204005 8.297244e-01 0.081 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.338967e-01 0.079 0 0
Collagen chain trimerization R-HSA-8948216 8.361158e-01 0.078 0 0
Metabolism of folate and pterines R-HSA-196757 8.361158e-01 0.078 0 0
G alpha (i) signalling events R-HSA-418594 8.376045e-01 0.077 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.380491e-01 0.077 0 0
Purine salvage R-HSA-74217 8.427246e-01 0.074 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.427246e-01 0.074 0 0
Elastic fibre formation R-HSA-1566948 8.427246e-01 0.074 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.490674e-01 0.071 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.507181e-01 0.070 0 0
Interferon gamma signaling R-HSA-877300 8.513463e-01 0.070 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.551547e-01 0.068 0 0
Attenuation phase R-HSA-3371568 8.551547e-01 0.068 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.551547e-01 0.068 0 0
Interleukin-2 family signaling R-HSA-451927 8.551547e-01 0.068 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.551547e-01 0.068 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.592197e-01 0.066 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.609968e-01 0.065 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.609968e-01 0.065 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.666037e-01 0.062 0 0
HIV Transcription Initiation R-HSA-167161 8.666037e-01 0.062 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.666037e-01 0.062 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.666037e-01 0.062 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.666037e-01 0.062 0 0
Selenoamino acid metabolism R-HSA-2408522 8.672475e-01 0.062 0 0
RNA Polymerase I Transcription R-HSA-73864 8.679639e-01 0.061 0 0
Integrin cell surface interactions R-HSA-216083 8.679639e-01 0.061 0 0
Parasitic Infection Pathways R-HSA-9824443 8.692902e-01 0.061 0 0
Leishmania infection R-HSA-9658195 8.692902e-01 0.061 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.700338e-01 0.060 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.719847e-01 0.059 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.719847e-01 0.059 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.719847e-01 0.059 0 0
Sensory processing of sound R-HSA-9659379 8.721465e-01 0.059 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.762068e-01 0.057 0 0
Viral Infection Pathways R-HSA-9824446 8.771422e-01 0.057 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.771490e-01 0.057 0 0
TBC/RABGAPs R-HSA-8854214 8.771490e-01 0.057 0 0
DAP12 interactions R-HSA-2172127 8.821052e-01 0.054 0 0
Gap junction trafficking R-HSA-190828 8.821052e-01 0.054 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.821052e-01 0.054 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.836756e-01 0.054 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.868618e-01 0.052 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.868618e-01 0.052 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.914268e-01 0.050 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.914268e-01 0.050 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.914268e-01 0.050 0 0
Synthesis of PC R-HSA-1483191 8.958078e-01 0.048 0 0
Intraflagellar transport R-HSA-5620924 9.000123e-01 0.046 0 0
GPER1 signaling R-HSA-9634597 9.000123e-01 0.046 0 0
Metal ion SLC transporters R-HSA-425410 9.000123e-01 0.046 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.040474e-01 0.044 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.040474e-01 0.044 0 0
Peptide hormone metabolism R-HSA-2980736 9.046567e-01 0.044 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.079199e-01 0.042 0 0
Post-translational protein modification R-HSA-597592 9.107741e-01 0.041 0 0
The phototransduction cascade R-HSA-2514856 9.116363e-01 0.040 0 0
Bacterial Infection Pathways R-HSA-9824439 9.134338e-01 0.039 0 0
Neurotransmitter release cycle R-HSA-112310 9.136421e-01 0.039 0 0
Nucleotide biosynthesis R-HSA-8956320 9.186259e-01 0.037 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.198512e-01 0.036 0 0
Signaling by Insulin receptor R-HSA-74752 9.218375e-01 0.035 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.244026e-01 0.034 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.280888e-01 0.032 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.280888e-01 0.032 0 0
Dectin-2 family R-HSA-5621480 9.309922e-01 0.031 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.309922e-01 0.031 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.338903e-01 0.030 0 0
Telomere Maintenance R-HSA-157579 9.360798e-01 0.029 0 0
Regulation of beta-cell development R-HSA-186712 9.364527e-01 0.029 0 0
RAB geranylgeranylation R-HSA-8873719 9.390189e-01 0.027 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.402543e-01 0.027 0 0
Nucleotide salvage R-HSA-8956321 9.414817e-01 0.026 0 0
Collagen degradation R-HSA-1442490 9.414817e-01 0.026 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.422310e-01 0.026 0 0
Heme signaling R-HSA-9707616 9.438451e-01 0.025 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.438451e-01 0.025 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.438451e-01 0.025 0 0
Transport of small molecules R-HSA-382551 9.439522e-01 0.025 0 0
Sphingolipid metabolism R-HSA-428157 9.472001e-01 0.024 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.512786e-01 0.022 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.512786e-01 0.022 0 0
Kidney development R-HSA-9830369 9.543070e-01 0.020 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.543070e-01 0.020 0 0
Platelet homeostasis R-HSA-418346 9.545010e-01 0.020 0 0
Keratinization R-HSA-6805567 9.547583e-01 0.020 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.561531e-01 0.019 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.596249e-01 0.018 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.603450e-01 0.018 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.612565e-01 0.017 0 0
Metal ion assimilation from the host R-HSA-9638482 9.612565e-01 0.017 0 0
Metabolism of porphyrins R-HSA-189445 9.612565e-01 0.017 0 0
Purine catabolism R-HSA-74259 9.628222e-01 0.016 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.688826e-01 0.014 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.704680e-01 0.013 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.709754e-01 0.013 0 0
Mitochondrial biogenesis R-HSA-1592230 9.709772e-01 0.013 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.721488e-01 0.012 0 0
PPARA activates gene expression R-HSA-1989781 9.731158e-01 0.012 0 0
Disease R-HSA-1643685 9.732632e-01 0.012 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.732749e-01 0.012 0 0
Phospholipid metabolism R-HSA-1483257 9.740967e-01 0.011 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.743555e-01 0.011 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.747543e-01 0.011 0 0
G alpha (q) signalling events R-HSA-416476 9.757427e-01 0.011 0 0
Extracellular matrix organization R-HSA-1474244 9.759276e-01 0.011 0 0
Diseases of metabolism R-HSA-5668914 9.764473e-01 0.010 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.788344e-01 0.009 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.788344e-01 0.009 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.788344e-01 0.009 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.795682e-01 0.009 0 0
Infectious disease R-HSA-5663205 9.796209e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.799822e-01 0.009 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.830302e-01 0.007 0 0
Base Excision Repair R-HSA-73884 9.830302e-01 0.007 0 0
Adipogenesis R-HSA-9843745 9.834797e-01 0.007 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.837168e-01 0.007 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.840566e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.843445e-01 0.007 0 0
FCGR activation R-HSA-2029481 9.856147e-01 0.006 0 0
Mitochondrial protein degradation R-HSA-9837999 9.861969e-01 0.006 0 0
Scavenging of heme from plasma R-HSA-2168880 9.872917e-01 0.006 0 0
Metabolism of steroids R-HSA-8957322 9.874821e-01 0.005 0 0
Mitochondrial translation elongation R-HSA-5389840 9.878061e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.878061e-01 0.005 0 0
Potassium Channels R-HSA-1296071 9.878061e-01 0.005 0 0
Drug ADME R-HSA-9748784 9.882129e-01 0.005 0 0
Mitochondrial translation initiation R-HSA-5368286 9.887734e-01 0.005 0 0
Regulation of insulin secretion R-HSA-422356 9.887734e-01 0.005 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.889110e-01 0.005 0 0
FOXO-mediated transcription R-HSA-9614085 9.892279e-01 0.005 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.904842e-01 0.004 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.908696e-01 0.004 0 0
Potential therapeutics for SARS R-HSA-9679191 9.922246e-01 0.003 0 0
Mitochondrial translation termination R-HSA-5419276 9.931643e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.934161e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.935469e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.937070e-01 0.003 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.942067e-01 0.003 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.951021e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.967660e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.967660e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.970693e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.973615e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.978833e-01 0.001 0 0
Mitochondrial translation R-HSA-5368287 9.983273e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.988950e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.990243e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.991020e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.994653e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997069e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.998431e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.998965e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998965e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999231e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999417e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999664e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999826e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999966e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 5.551115e-16 15.256 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.125278e-13 12.505 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.062440e-13 12.094 0 0
Mitotic Prophase R-HSA-68875 3.063994e-12 11.514 0 0
Cellular Senescence R-HSA-2559583 4.797385e-12 11.319 0 0
Chromatin modifying enzymes R-HSA-3247509 9.675705e-12 11.014 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.753575e-11 10.560 0 0
Chromatin organization R-HSA-4839726 3.629785e-11 10.440 0 0
HDACs deacetylate histones R-HSA-3214815 2.624102e-10 9.581 0 0
Cell Cycle Checkpoints R-HSA-69620 4.030344e-10 9.395 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.573647e-10 9.254 0 0
Cellular response to heat stress R-HSA-3371556 4.419040e-09 8.355 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.356621e-09 8.197 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.302589e-09 8.200 0 0
HATs acetylate histones R-HSA-3214847 6.173883e-09 8.209 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.541139e-09 8.068 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.520716e-09 8.021 0 0
Nucleosome assembly R-HSA-774815 9.520716e-09 8.021 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.089732e-08 7.963 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.277854e-08 7.894 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.276243e-08 7.894 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.786274e-08 7.748 0 0
Mitotic Prometaphase R-HSA-68877 2.462036e-08 7.609 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.798161e-08 7.420 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.642386e-08 7.333 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.997172e-08 7.301 0 0
Defective pyroptosis R-HSA-9710421 5.401808e-08 7.267 0 0
Meiotic synapsis R-HSA-1221632 5.897439e-08 7.229 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.633036e-08 7.249 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.164711e-08 7.210 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.443046e-08 7.191 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.443046e-08 7.191 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.489876e-08 7.071 0 0
HSF1-dependent transactivation R-HSA-3371571 9.441158e-08 7.025 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.248905e-08 7.034 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.576138e-08 7.019 0 0
Cell-Cell communication R-HSA-1500931 9.501616e-08 7.022 0 0
DNA methylation R-HSA-5334118 1.504477e-07 6.823 0 0
Axon guidance R-HSA-422475 1.724950e-07 6.763 0 0
Diseases of programmed cell death R-HSA-9645723 1.953804e-07 6.709 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.965122e-07 6.707 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.193399e-07 6.659 0 0
Nervous system development R-HSA-9675108 2.156339e-07 6.666 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.919746e-07 6.535 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.656887e-07 6.437 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.652390e-07 6.437 0 0
Cell junction organization R-HSA-446728 5.034992e-07 6.298 0 0
Signal Transduction R-HSA-162582 5.630559e-07 6.249 0 0
G2/M Checkpoints R-HSA-69481 6.779967e-07 6.169 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.361970e-07 6.133 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.524908e-07 6.069 0 0
Packaging Of Telomere Ends R-HSA-171306 9.372598e-07 6.028 0 0
Meiosis R-HSA-1500620 1.246474e-06 5.904 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.366509e-06 5.864 0 0
Attenuation phase R-HSA-3371568 1.601588e-06 5.795 0 0
Apoptotic execution phase R-HSA-75153 1.738820e-06 5.760 0 0
Signaling by WNT R-HSA-195721 1.951018e-06 5.710 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.962931e-06 5.707 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.118788e-06 5.674 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.279468e-06 5.642 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.392168e-06 5.621 0 0
Adherens junctions interactions R-HSA-418990 2.989164e-06 5.524 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.298187e-06 5.482 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.335746e-06 5.477 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.542501e-06 5.451 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.591761e-06 5.445 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.138176e-06 5.289 0 0
Deubiquitination R-HSA-5688426 5.560285e-06 5.255 0 0
ESR-mediated signaling R-HSA-8939211 6.003396e-06 5.222 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.192414e-06 5.143 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.393505e-06 5.131 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.393505e-06 5.131 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.411521e-06 5.130 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.572583e-06 5.121 0 0
Mitotic Anaphase R-HSA-68882 7.870041e-06 5.104 0 0
Meiotic recombination R-HSA-912446 8.105351e-06 5.091 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.980728e-06 5.047 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.439551e-05 4.842 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.552199e-05 4.809 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.594579e-05 4.797 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.859255e-05 4.731 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.940855e-05 4.712 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.177960e-05 4.662 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.222331e-05 4.653 0 0
DNA Double Strand Break Response R-HSA-5693606 2.745075e-05 4.561 0 0
Co-inhibition by PD-1 R-HSA-389948 3.174798e-05 4.498 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.197387e-05 4.495 0 0
Cell-cell junction organization R-HSA-421270 3.266643e-05 4.486 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.463928e-05 4.460 0 0
mRNA Splicing R-HSA-72172 3.320026e-05 4.479 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.507666e-05 4.455 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.950767e-05 4.403 0 0
Depyrimidination R-HSA-73928 3.950767e-05 4.403 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.031926e-05 4.394 0 0
HSF1 activation R-HSA-3371511 4.121343e-05 4.385 0 0
Metabolism of RNA R-HSA-8953854 5.076109e-05 4.294 0 0
Gene Silencing by RNA R-HSA-211000 4.960596e-05 4.304 0 0
RNA Polymerase I Transcription R-HSA-73864 5.357702e-05 4.271 0 0
Cleavage of the damaged purine R-HSA-110331 5.614816e-05 4.251 0 0
Separation of Sister Chromatids R-HSA-2467813 5.707346e-05 4.244 0 0
Depurination R-HSA-73927 7.571540e-05 4.121 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.797153e-05 4.108 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.849949e-05 4.105 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.024399e-05 4.045 0 0
Homology Directed Repair R-HSA-5693538 1.010407e-04 3.996 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.022102e-04 3.991 0 0
Ub-specific processing proteases R-HSA-5689880 1.158952e-04 3.936 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.438505e-04 3.842 0 0
Chromosome Maintenance R-HSA-73886 1.600635e-04 3.796 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.532250e-04 3.815 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.572008e-04 3.804 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.589249e-04 3.799 0 0
Gene expression (Transcription) R-HSA-74160 1.746380e-04 3.758 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.896177e-04 3.722 0 0
Selective autophagy R-HSA-9663891 1.988621e-04 3.701 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.092736e-04 3.679 0 0
Signaling by ALK in cancer R-HSA-9700206 2.092736e-04 3.679 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.489147e-04 3.604 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.489147e-04 3.604 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.446971e-04 3.611 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.371062e-04 3.625 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.547979e-04 3.594 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.594275e-04 3.586 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.605294e-04 3.584 0 0
G alpha (12/13) signalling events R-HSA-416482 2.716638e-04 3.566 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.855110e-04 3.544 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.878696e-04 3.541 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.878696e-04 3.541 0 0
L1CAM interactions R-HSA-373760 2.878696e-04 3.541 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.098484e-04 3.509 0 0
Translation initiation complex formation R-HSA-72649 3.112486e-04 3.507 0 0
UCH proteinases R-HSA-5689603 4.087814e-04 3.389 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.690056e-04 3.329 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.777095e-04 3.321 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.778921e-04 3.321 0 0
NRAGE signals death through JNK R-HSA-193648 4.778921e-04 3.321 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.800987e-04 3.319 0 0
Ephrin signaling R-HSA-3928664 5.007166e-04 3.300 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.123636e-04 3.290 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.330575e-04 3.273 0 0
DNA Repair R-HSA-73894 5.389598e-04 3.268 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.528282e-04 3.257 0 0
HCMV Early Events R-HSA-9609690 5.540257e-04 3.256 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.129998e-04 3.213 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.068968e-04 3.151 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.355031e-04 3.133 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.614978e-04 3.118 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.903505e-04 3.102 0 0
Signaling by NTRKs R-HSA-166520 8.482928e-04 3.071 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.694027e-04 3.061 0 0
DNA Replication R-HSA-69306 8.725407e-04 3.059 0 0
EPH-Ephrin signaling R-HSA-2682334 9.264485e-04 3.033 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.427087e-04 3.026 0 0
Metalloprotease DUBs R-HSA-5689901 9.811256e-04 3.008 0 0
Macroautophagy R-HSA-1632852 1.011108e-03 2.995 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.124603e-03 2.949 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.119979e-03 2.951 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.119979e-03 2.951 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.119979e-03 2.951 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.158930e-03 2.936 0 0
RMTs methylate histone arginines R-HSA-3214858 1.170841e-03 2.932 0 0
Signaling by Hippo R-HSA-2028269 1.179174e-03 2.928 0 0
Autophagy R-HSA-9612973 1.224920e-03 2.912 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.308600e-03 2.883 0 0
DCC mediated attractive signaling R-HSA-418885 1.335237e-03 2.874 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.335237e-03 2.874 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.439036e-03 2.842 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.835380e-03 2.736 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.858032e-03 2.731 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.858032e-03 2.731 0 0
Signaling by VEGF R-HSA-194138 1.992266e-03 2.701 0 0
Recycling pathway of L1 R-HSA-437239 2.175325e-03 2.662 0 0
Base Excision Repair R-HSA-73884 2.242100e-03 2.649 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.280405e-03 2.642 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.282123e-03 2.642 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.549708e-03 2.594 0 0
G2/M Transition R-HSA-69275 2.394334e-03 2.621 0 0
GPER1 signaling R-HSA-9634597 2.640665e-03 2.578 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.735987e-03 2.563 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.821979e-03 2.549 0 0
Regulation of CDH1 Function R-HSA-9764561 2.873817e-03 2.542 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.889280e-03 2.539 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.889280e-03 2.539 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.202916e-03 2.494 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.386671e-03 2.470 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.450355e-03 2.462 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.467224e-03 2.460 0 0
Signaling by NOTCH R-HSA-157118 3.539767e-03 2.451 0 0
Semaphorin interactions R-HSA-373755 3.771435e-03 2.423 0 0
Amyloid fiber formation R-HSA-977225 3.778431e-03 2.423 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.915295e-03 2.407 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.018784e-03 2.396 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.018784e-03 2.396 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.018784e-03 2.396 0 0
Signaling by RAS mutants R-HSA-6802949 4.018784e-03 2.396 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.320059e-03 2.365 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.351713e-03 2.361 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.425775e-03 2.354 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.567912e-03 2.340 0 0
mRNA 3'-end processing R-HSA-72187 5.415195e-03 2.266 0 0
NGF-stimulated transcription R-HSA-9031628 5.757143e-03 2.240 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.954800e-03 2.225 0 0
Apoptosis R-HSA-109581 6.071863e-03 2.217 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.093432e-03 2.215 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.212259e-03 2.207 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.430727e-03 2.192 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.430727e-03 2.192 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.500946e-03 2.187 0 0
Reproduction R-HSA-1474165 6.564509e-03 2.183 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.704432e-03 2.174 0 0
Signaling by ROBO receptors R-HSA-376176 6.840905e-03 2.165 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.082268e-03 2.150 0 0
mTORC1-mediated signalling R-HSA-166208 7.082268e-03 2.150 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.114195e-03 2.148 0 0
Myogenesis R-HSA-525793 7.174294e-03 2.144 0 0
Telomere Maintenance R-HSA-157579 7.192337e-03 2.143 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.360967e-03 2.133 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.518520e-03 2.124 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.518520e-03 2.124 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.793848e-03 2.056 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.793848e-03 2.056 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.630284e-03 2.064 0 0
G alpha (z) signalling events R-HSA-418597 8.785902e-03 2.056 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.439709e-03 2.074 0 0
Nuclear import of Rev protein R-HSA-180746 8.490351e-03 2.071 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.729859e-03 2.012 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.952423e-03 2.002 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.963629e-03 2.002 0 0
RNA Polymerase II Transcription R-HSA-73857 1.006113e-02 1.997 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.037976e-02 1.984 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.040687e-02 1.983 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.058125e-02 1.975 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.058125e-02 1.975 0 0
PTEN Regulation R-HSA-6807070 1.066915e-02 1.972 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.090011e-02 1.963 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.114235e-02 1.953 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.138294e-02 1.944 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.149537e-02 1.939 0 0
Aggrephagy R-HSA-9646399 1.165493e-02 1.933 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.165493e-02 1.933 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.171544e-02 1.931 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.239223e-02 1.907 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.239223e-02 1.907 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.273074e-02 1.895 0 0
Netrin-1 signaling R-HSA-373752 1.287251e-02 1.890 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.287251e-02 1.890 0 0
Programmed Cell Death R-HSA-5357801 1.287902e-02 1.890 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.374547e-02 1.862 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.434045e-02 1.843 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.434045e-02 1.843 0 0
HDMs demethylate histones R-HSA-3214842 1.416382e-02 1.849 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.307423e-02 1.884 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.478900e-02 1.830 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.505804e-02 1.822 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.418121e-02 1.848 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.418121e-02 1.848 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.307423e-02 1.884 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.382458e-02 1.859 0 0
Membrane Trafficking R-HSA-199991 1.411994e-02 1.850 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.480153e-02 1.830 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.548765e-02 1.810 0 0
HCMV Infection R-HSA-9609646 1.566496e-02 1.805 0 0
Metabolism of non-coding RNA R-HSA-194441 1.570590e-02 1.804 0 0
snRNP Assembly R-HSA-191859 1.570590e-02 1.804 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.574043e-02 1.803 0 0
Striated Muscle Contraction R-HSA-390522 1.574043e-02 1.803 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.574043e-02 1.803 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.592017e-02 1.798 0 0
Activation of the pre-replicative complex R-HSA-68962 1.664059e-02 1.779 0 0
Nef and signal transduction R-HSA-164944 1.674238e-02 1.776 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.674293e-02 1.776 0 0
IRE1alpha activates chaperones R-HSA-381070 1.680189e-02 1.775 0 0
Repression of WNT target genes R-HSA-4641265 1.699842e-02 1.770 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.699842e-02 1.770 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.739052e-02 1.760 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.739052e-02 1.760 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.743206e-02 1.759 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.805625e-02 1.743 0 0
Peptide chain elongation R-HSA-156902 1.850291e-02 1.733 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.865926e-02 1.729 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.880142e-02 1.726 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.884475e-02 1.725 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.911012e-02 1.719 0 0
Centrosome maturation R-HSA-380287 1.970577e-02 1.705 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.970577e-02 1.705 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.065920e-02 1.685 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.079762e-02 1.682 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.079762e-02 1.682 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.123119e-02 1.673 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.123119e-02 1.673 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.153994e-02 1.667 0 0
Developmental Biology R-HSA-1266738 2.181928e-02 1.661 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.269711e-02 1.644 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.300327e-02 1.638 0 0
Signal transduction by L1 R-HSA-445144 2.300327e-02 1.638 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.303269e-02 1.638 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.325811e-02 1.633 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.844148e-02 1.546 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.844148e-02 1.546 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.844148e-02 1.546 0 0
IRS activation R-HSA-74713 2.844148e-02 1.546 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.844148e-02 1.546 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.491185e-02 1.604 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.838996e-02 1.547 0 0
Nuclear RNA decay R-HSA-9930044 2.838996e-02 1.547 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.838996e-02 1.547 0 0
Post NMDA receptor activation events R-HSA-438064 2.800294e-02 1.553 0 0
Death Receptor Signaling R-HSA-73887 2.648083e-02 1.577 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.418086e-02 1.617 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.850921e-02 1.545 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.943161e-02 1.531 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.959382e-02 1.529 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.968030e-02 1.528 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.059845e-02 1.514 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.091767e-02 1.510 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.130601e-02 1.504 0 0
MAP2K and MAPK activation R-HSA-5674135 3.253461e-02 1.488 0 0
Kinesins R-HSA-983189 3.270563e-02 1.485 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.279847e-02 1.484 0 0
HCMV Late Events R-HSA-9610379 3.305513e-02 1.481 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.388906e-02 1.470 0 0
PKR-mediated signaling R-HSA-9833482 3.415530e-02 1.467 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.487845e-02 1.457 0 0
Type I hemidesmosome assembly R-HSA-446107 3.527459e-02 1.453 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.527459e-02 1.453 0 0
Ribosome-associated quality control R-HSA-9948299 3.560742e-02 1.448 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.563634e-02 1.448 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.610320e-02 1.442 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.664816e-02 1.436 0 0
Influenza Infection R-HSA-168255 3.737768e-02 1.427 0 0
MTOR signalling R-HSA-165159 3.741844e-02 1.427 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.768352e-02 1.424 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.768352e-02 1.424 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.777854e-02 1.423 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.813331e-02 1.419 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.881036e-02 1.411 0 0
Mitophagy R-HSA-5205647 3.899077e-02 1.409 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.016759e-02 1.396 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.060647e-02 1.391 0 0
Regulation of TP53 Activity R-HSA-5633007 4.082043e-02 1.389 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.114290e-02 1.386 0 0
tRNA processing in the nucleus R-HSA-6784531 4.121512e-02 1.385 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.121512e-02 1.385 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 4.253246e-02 1.371 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 4.253246e-02 1.371 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 4.253246e-02 1.371 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.259252e-02 1.371 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.286829e-02 1.368 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.286829e-02 1.368 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.286829e-02 1.368 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.286829e-02 1.368 0 0
Eukaryotic Translation Termination R-HSA-72764 4.482502e-02 1.348 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.533647e-02 1.344 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.903989e-02 1.309 0 0
MET activates PTPN11 R-HSA-8865999 4.903989e-02 1.309 0 0
WNT mediated activation of DVL R-HSA-201688 4.795082e-02 1.319 0 0
ALK mutants bind TKIs R-HSA-9700645 4.795082e-02 1.319 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.040635e-02 1.298 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.623167e-02 1.335 0 0
Integrin signaling R-HSA-354192 5.748376e-02 1.240 0 0
Ca2+ pathway R-HSA-4086398 4.627558e-02 1.335 0 0
Signaling by ERBB2 R-HSA-1227986 5.679817e-02 1.246 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.867697e-02 1.313 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.641720e-02 1.333 0 0
Circadian clock R-HSA-9909396 4.625399e-02 1.335 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.625399e-02 1.335 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.748376e-02 1.240 0 0
Protein ubiquitination R-HSA-8852135 5.633129e-02 1.249 0 0
rRNA processing R-HSA-72312 5.131935e-02 1.290 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.641720e-02 1.333 0 0
RET signaling R-HSA-8853659 5.210101e-02 1.283 0 0
Unwinding of DNA R-HSA-176974 4.795082e-02 1.319 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.389602e-02 1.268 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.739796e-02 1.241 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.827905e-02 1.234 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.827905e-02 1.234 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.964361e-02 1.224 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.964361e-02 1.224 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.966047e-02 1.224 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.968440e-02 1.224 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.072053e-02 1.217 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.072053e-02 1.217 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.072053e-02 1.217 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.118423e-02 1.213 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.145468e-02 1.211 0 0
Formation of axial mesoderm R-HSA-9796292 6.145468e-02 1.211 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.164319e-02 1.210 0 0
MAPK family signaling cascades R-HSA-5683057 6.188821e-02 1.208 0 0
Interleukin-12 signaling R-HSA-9020591 6.189548e-02 1.208 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.219075e-02 1.206 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.243106e-02 1.205 0 0
Signal attenuation R-HSA-74749 6.299472e-02 1.201 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.299472e-02 1.201 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.299472e-02 1.201 0 0
Regulation of CDH11 function R-HSA-9762292 6.299472e-02 1.201 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.299472e-02 1.201 0 0
Signaling by EGFR R-HSA-177929 6.304780e-02 1.200 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.340788e-02 1.198 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.340788e-02 1.198 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.389234e-02 1.195 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.395059e-02 1.194 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.496560e-02 1.187 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.509639e-02 1.186 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.598957e-02 1.181 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.608012e-02 1.180 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.676963e-02 1.175 0 0
Heme signaling R-HSA-9707616 6.974291e-02 1.156 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.989972e-02 1.156 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.989972e-02 1.156 0 0
Long-term potentiation R-HSA-9620244 6.989972e-02 1.156 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.067690e-02 1.151 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.067690e-02 1.151 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.181167e-02 1.144 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.323028e-02 1.135 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.323028e-02 1.135 0 0
RAF activation R-HSA-5673000 7.546717e-02 1.122 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.546717e-02 1.122 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.546717e-02 1.122 0 0
Regulation of gap junction activity R-HSA-191650 7.547713e-02 1.122 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 7.547713e-02 1.122 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 7.547713e-02 1.122 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 7.547713e-02 1.122 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 7.547713e-02 1.122 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.603586e-02 1.119 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.611518e-02 1.119 0 0
Signaling by ALK R-HSA-201556 7.687988e-02 1.114 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.695889e-02 1.114 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.695889e-02 1.114 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.695889e-02 1.114 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.766351e-02 1.110 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.920389e-02 1.101 0 0
Manipulation of host energy metabolism R-HSA-9636667 8.621448e-02 1.064 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 8.621448e-02 1.064 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 8.621448e-02 1.064 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 8.621448e-02 1.064 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.068741e-01 0.971 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.068741e-01 0.971 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.068741e-01 0.971 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.068741e-01 0.971 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.191006e-02 1.087 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.062359e-01 0.974 0 0
MET receptor recycling R-HSA-8875656 1.062359e-01 0.974 0 0
Formation of annular gap junctions R-HSA-196025 1.062359e-01 0.974 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.240547e-02 1.034 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.240547e-02 1.034 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.118946e-02 1.091 0 0
Trafficking of AMPA receptors R-HSA-399719 8.395591e-02 1.076 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.696963e-02 1.013 0 0
Oncogene Induced Senescence R-HSA-2559585 8.565527e-02 1.067 0 0
Nucleotide Excision Repair R-HSA-5696398 1.052930e-01 0.978 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.674348e-02 1.014 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.674348e-02 1.014 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.240547e-02 1.034 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.656312e-02 1.063 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.673525e-02 1.062 0 0
Generic Transcription Pathway R-HSA-212436 1.031972e-01 0.986 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.664866e-02 1.015 0 0
DAG and IP3 signaling R-HSA-1489509 9.674348e-02 1.014 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.696963e-02 1.013 0 0
Cellular response to starvation R-HSA-9711097 9.888260e-02 1.005 0 0
S Phase R-HSA-69242 1.046951e-01 0.980 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.539588e-02 1.020 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.621448e-02 1.064 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.452537e-02 1.073 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.981184e-02 1.001 0 0
Degradation of CDH1 R-HSA-9766229 8.673525e-02 1.062 0 0
Cellular response to chemical stress R-HSA-9711123 1.002359e-01 0.999 0 0
PECAM1 interactions R-HSA-210990 8.039684e-02 1.095 0 0
NrCAM interactions R-HSA-447038 1.068741e-01 0.971 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.674348e-02 1.014 0 0
Host Interactions of HIV factors R-HSA-162909 1.008079e-01 0.997 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.395591e-02 1.076 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.043073e-01 0.982 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.565527e-02 1.067 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.612401e-02 1.017 0 0
Diseases of DNA repair R-HSA-9675135 1.072679e-01 0.970 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.077479e-01 0.968 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.081255e-01 0.966 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.081255e-01 0.966 0 0
G-protein beta:gamma signalling R-HSA-397795 1.081255e-01 0.966 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.081425e-01 0.966 0 0
Selenocysteine synthesis R-HSA-2408557 1.081425e-01 0.966 0 0
Interleukin-12 family signaling R-HSA-447115 1.088126e-01 0.963 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.105162e-01 0.957 0 0
Prolonged ERK activation events R-HSA-169893 1.105162e-01 0.957 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.133671e-01 0.946 0 0
Protein folding R-HSA-391251 1.140452e-01 0.943 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.165032e-01 0.934 0 0
Nephrin family interactions R-HSA-373753 1.165032e-01 0.934 0 0
Orc1 removal from chromatin R-HSA-68949 1.166545e-01 0.933 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.166545e-01 0.933 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.170507e-01 0.932 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.173724e-01 0.930 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.196236e-01 0.922 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.197607e-01 0.922 0 0
Deadenylation of mRNA R-HSA-429947 1.197607e-01 0.922 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.197607e-01 0.922 0 0
Neurodegenerative Diseases R-HSA-8863678 1.197607e-01 0.922 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.197607e-01 0.922 0 0
Activation of GABAB receptors R-HSA-991365 1.199456e-01 0.921 0 0
GABA B receptor activation R-HSA-977444 1.199456e-01 0.921 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.210374e-01 0.917 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.210374e-01 0.917 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.219534e-01 0.914 0 0
Disorders of Nervous System Development R-HSA-9697154 1.219534e-01 0.914 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.219534e-01 0.914 0 0
Pervasive developmental disorders R-HSA-9005895 1.219534e-01 0.914 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.219534e-01 0.914 0 0
Signaling by LTK R-HSA-9842663 1.219534e-01 0.914 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.219534e-01 0.914 0 0
Sensory processing of sound R-HSA-9659379 1.233670e-01 0.909 0 0
Viral mRNA Translation R-HSA-192823 1.236625e-01 0.908 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.272544e-01 0.895 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.272544e-01 0.895 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.272544e-01 0.895 0 0
Smooth Muscle Contraction R-HSA-445355 1.278213e-01 0.893 0 0
Disorders of Developmental Biology R-HSA-9675151 1.302912e-01 0.885 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.334106e-01 0.875 0 0
Gap junction degradation R-HSA-190873 1.334106e-01 0.875 0 0
Calcineurin activates NFAT R-HSA-2025928 1.334106e-01 0.875 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.334106e-01 0.875 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.345470e-01 0.871 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.358546e-01 0.867 0 0
Dual Incision in GG-NER R-HSA-5696400 1.358546e-01 0.867 0 0
Signal amplification R-HSA-392518 1.358546e-01 0.867 0 0
TGFBR3 expression R-HSA-9839394 1.363553e-01 0.865 0 0
DAP12 signaling R-HSA-2424491 1.366139e-01 0.865 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.382947e-01 0.859 0 0
Regulation of TP53 Expression R-HSA-6804754 1.382947e-01 0.859 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.382947e-01 0.859 0 0
Diseases of cellular response to stress R-HSA-9675132 1.382947e-01 0.859 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.382947e-01 0.859 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.382947e-01 0.859 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.382947e-01 0.859 0 0
Signalling to ERK5 R-HSA-198765 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.382947e-01 0.859 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.382947e-01 0.859 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.382947e-01 0.859 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.382947e-01 0.859 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 1.382947e-01 0.859 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.382947e-01 0.859 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.403010e-01 0.853 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.497909e-01 0.825 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.497909e-01 0.825 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.497909e-01 0.825 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.497909e-01 0.825 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.497909e-01 0.825 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.497909e-01 0.825 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.952791e-01 0.709 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.952791e-01 0.709 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.424200e-01 0.846 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.424200e-01 0.846 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.630849e-01 0.788 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.630849e-01 0.788 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.458269e-01 0.836 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.458269e-01 0.836 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.458269e-01 0.836 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.987930e-01 0.702 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.987930e-01 0.702 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.744014e-01 0.758 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.744014e-01 0.758 0 0
GAB1 signalosome R-HSA-180292 1.744014e-01 0.758 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 1.744014e-01 0.758 0 0
PKA activation in glucagon signalling R-HSA-164378 1.744014e-01 0.758 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.538737e-01 0.813 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.540419e-01 0.812 0 0
Notch-HLH transcription pathway R-HSA-350054 1.743981e-01 0.758 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.701522e-01 0.769 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.924372e-01 0.716 0 0
Late endosomal microautophagy R-HSA-9615710 2.129955e-01 0.672 0 0
Degradation of DVL R-HSA-4641258 1.836891e-01 0.736 0 0
MET promotes cell motility R-HSA-8875878 2.011446e-01 0.696 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.690339e-01 0.772 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.104634e-01 0.677 0 0
Cellular response to hypoxia R-HSA-1234174 1.441228e-01 0.841 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.540419e-01 0.812 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.427263e-01 0.845 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.427263e-01 0.845 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.701522e-01 0.769 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.492804e-01 0.826 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.727595e-01 0.763 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.742277e-01 0.759 0 0
Polo-like kinase mediated events R-HSA-156711 1.744014e-01 0.758 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.065910e-01 0.685 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.510010e-01 0.821 0 0
Signalling to ERKs R-HSA-187687 1.510010e-01 0.821 0 0
G-protein mediated events R-HSA-112040 1.676581e-01 0.776 0 0
Gap junction trafficking and regulation R-HSA-157858 1.427263e-01 0.845 0 0
Hedgehog 'off' state R-HSA-5610787 2.009707e-01 0.697 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.601702e-01 0.795 0 0
Calmodulin induced events R-HSA-111933 1.669592e-01 0.777 0 0
Opioid Signalling R-HSA-111885 1.837814e-01 0.736 0 0
CaM pathway R-HSA-111997 1.669592e-01 0.777 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.983292e-01 0.703 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.983292e-01 0.703 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.860196e-01 0.730 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.051279e-01 0.688 0 0
Mitochondrial biogenesis R-HSA-1592230 1.760347e-01 0.754 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.630849e-01 0.788 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.952791e-01 0.709 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.960219e-01 0.708 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.952277e-01 0.709 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.863998e-01 0.730 0 0
Signaling by PTK6 R-HSA-8848021 1.860196e-01 0.730 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.860196e-01 0.730 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.540419e-01 0.812 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.960219e-01 0.708 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.098577e-01 0.678 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.129955e-01 0.672 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.567398e-01 0.805 0 0
Signaling by NOTCH4 R-HSA-9013694 1.867343e-01 0.729 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.924372e-01 0.716 0 0
MAP kinase activation R-HSA-450294 1.601685e-01 0.795 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.744014e-01 0.758 0 0
Presynaptic function of Kainate receptors R-HSA-500657 1.744014e-01 0.758 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.727595e-01 0.763 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.924372e-01 0.716 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.626365e-01 0.789 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.927512e-01 0.715 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.882298e-01 0.725 0 0
Potential therapeutics for SARS R-HSA-9679191 2.040545e-01 0.690 0 0
Glycolysis R-HSA-70171 2.009707e-01 0.697 0 0
Signaling by Leptin R-HSA-2586552 1.630849e-01 0.788 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.647836e-01 0.783 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.138635e-01 0.670 0 0
Stabilization of p53 R-HSA-69541 2.192744e-01 0.659 0 0
Inositol phosphate metabolism R-HSA-1483249 2.199287e-01 0.658 0 0
DNA Damage Bypass R-HSA-73893 2.215060e-01 0.655 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.224882e-01 0.653 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.224882e-01 0.653 0 0
PTK6 Expression R-HSA-8849473 2.224882e-01 0.653 0 0
Disinhibition of SNARE formation R-HSA-114516 2.224882e-01 0.653 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.224882e-01 0.653 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.224882e-01 0.653 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.236765e-01 0.650 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.274258e-01 0.643 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.274258e-01 0.643 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.274258e-01 0.643 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.283614e-01 0.641 0 0
Gap junction trafficking R-HSA-190828 2.295483e-01 0.639 0 0
Signaling by NOTCH3 R-HSA-9012852 2.296798e-01 0.639 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.343476e-01 0.630 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.343476e-01 0.630 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.368471e-01 0.626 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.368471e-01 0.626 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.380227e-01 0.623 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.392576e-01 0.621 0 0
Interleukin-7 signaling R-HSA-1266695 2.421236e-01 0.616 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.431823e-01 0.614 0 0
TNF signaling R-HSA-75893 2.459515e-01 0.609 0 0
PERK regulates gene expression R-HSA-381042 2.469629e-01 0.607 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.475352e-01 0.606 0 0
ERK/MAPK targets R-HSA-198753 2.498565e-01 0.602 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.771517e-01 0.557 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.771517e-01 0.557 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.771517e-01 0.557 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.771517e-01 0.557 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.771517e-01 0.557 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.771517e-01 0.557 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.771517e-01 0.557 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.771517e-01 0.557 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.771517e-01 0.557 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.771517e-01 0.557 0 0
Hereditary fructose intolerance R-HSA-5657560 2.771517e-01 0.557 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.771517e-01 0.557 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.771517e-01 0.557 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.771517e-01 0.557 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.771517e-01 0.557 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.771517e-01 0.557 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.771517e-01 0.557 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.771517e-01 0.557 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.545312e-01 0.594 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.545312e-01 0.594 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.545312e-01 0.594 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.545312e-01 0.594 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.545312e-01 0.594 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.545312e-01 0.594 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.854402e-01 0.414 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.854402e-01 0.414 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.854402e-01 0.414 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.854402e-01 0.414 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 3.854402e-01 0.414 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.854402e-01 0.414 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.854402e-01 0.414 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.854402e-01 0.414 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.854402e-01 0.414 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.854402e-01 0.414 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.854402e-01 0.414 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.854402e-01 0.414 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 3.854402e-01 0.414 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.140938e-01 0.503 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.140938e-01 0.503 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.140938e-01 0.503 0 0
NTRK2 activates RAC1 R-HSA-9032759 3.140938e-01 0.503 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.653317e-01 0.576 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.653317e-01 0.576 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.653317e-01 0.576 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.631469e-01 0.580 0 0
ARMS-mediated activation R-HSA-170984 3.090342e-01 0.510 0 0
Lipophagy R-HSA-9613354 3.090342e-01 0.510 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.725451e-01 0.429 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.725451e-01 0.429 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.725451e-01 0.429 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.775115e-01 0.321 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 4.775115e-01 0.321 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.775115e-01 0.321 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 4.775115e-01 0.321 0 0
Potassium transport channels R-HSA-1296067 4.775115e-01 0.321 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.775115e-01 0.321 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.775115e-01 0.321 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.775115e-01 0.321 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.988279e-01 0.525 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.988279e-01 0.525 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.988279e-01 0.525 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.988279e-01 0.525 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.529405e-01 0.452 0 0
2-LTR circle formation R-HSA-164843 3.529405e-01 0.452 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.529405e-01 0.452 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.877584e-01 0.541 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.877584e-01 0.541 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.768387e-01 0.558 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.350253e-01 0.475 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.288818e-01 0.368 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 4.288818e-01 0.368 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.288818e-01 0.368 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.288818e-01 0.368 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.288818e-01 0.368 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.288818e-01 0.368 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.189607e-01 0.496 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.044499e-01 0.516 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.964879e-01 0.402 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.964879e-01 0.402 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.912202e-01 0.536 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.713877e-01 0.430 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.678047e-01 0.572 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.505324e-01 0.455 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.165737e-01 0.500 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.022234e-01 0.520 0 0
Negative regulation of MET activity R-HSA-6807004 3.822470e-01 0.418 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.822470e-01 0.418 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.822470e-01 0.418 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.822470e-01 0.418 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.822470e-01 0.418 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.822470e-01 0.418 0 0
Phosphorylation of the APC/C R-HSA-176412 4.075962e-01 0.390 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.392060e-01 0.357 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.392060e-01 0.357 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.392060e-01 0.357 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.392060e-01 0.357 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.824258e-01 0.317 0 0
SOS-mediated signalling R-HSA-112412 4.824258e-01 0.317 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.824258e-01 0.317 0 0
Recycling of eIF2:GDP R-HSA-72731 4.824258e-01 0.317 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.824258e-01 0.317 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.824258e-01 0.317 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.893618e-01 0.410 0 0
G protein gated Potassium channels R-HSA-1296059 3.893618e-01 0.410 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.893618e-01 0.410 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.138929e-01 0.383 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.138929e-01 0.383 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.943263e-01 0.404 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.807122e-01 0.318 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.807122e-01 0.318 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.807122e-01 0.318 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.807122e-01 0.318 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.807122e-01 0.318 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.807122e-01 0.318 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.807122e-01 0.318 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.812759e-01 0.419 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.812759e-01 0.419 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.452763e-01 0.351 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.006205e-01 0.397 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.714478e-01 0.430 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.026590e-01 0.395 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.042197e-01 0.393 0 0
FGFR2 alternative splicing R-HSA-6803529 4.762222e-01 0.322 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.721099e-01 0.326 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.702268e-01 0.328 0 0
Signaling by Erythropoietin R-HSA-9006335 5.016751e-01 0.300 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.702268e-01 0.328 0 0
RNA Polymerase III Transcription R-HSA-74158 2.678047e-01 0.572 0 0
EGFR downregulation R-HSA-182971 3.943263e-01 0.404 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.433674e-01 0.353 0 0
Generation of second messenger molecules R-HSA-202433 3.554088e-01 0.449 0 0
Signaling by MET R-HSA-6806834 2.683212e-01 0.571 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.556451e-01 0.592 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.877584e-01 0.541 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.016751e-01 0.300 0 0
Integration of provirus R-HSA-162592 4.392060e-01 0.357 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.914868e-01 0.535 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.682511e-01 0.434 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.762222e-01 0.322 0 0
Neurexins and neuroligins R-HSA-6794361 2.733759e-01 0.563 0 0
G-protein activation R-HSA-202040 4.138929e-01 0.383 0 0
Nephron development R-HSA-9831926 3.189607e-01 0.496 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.852521e-01 0.314 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.725451e-01 0.429 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 4.288818e-01 0.368 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 4.288818e-01 0.368 0 0
DNA strand elongation R-HSA-69190 2.790594e-01 0.554 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.075962e-01 0.390 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.824258e-01 0.317 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.436426e-01 0.464 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.233466e-01 0.490 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.807122e-01 0.318 0 0
Synthesis of DNA R-HSA-69239 2.986439e-01 0.525 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.907652e-01 0.309 0 0
Mismatch Repair R-HSA-5358508 3.189607e-01 0.496 0 0
GPVI-mediated activation cascade R-HSA-114604 2.678047e-01 0.572 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.631469e-01 0.580 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.682511e-01 0.434 0 0
PCP/CE pathway R-HSA-4086400 3.259232e-01 0.487 0 0
Signaling by WNT in cancer R-HSA-4791275 4.204008e-01 0.376 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.907652e-01 0.309 0 0
Signaling by FGFR4 R-HSA-5654743 4.459324e-01 0.351 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.505324e-01 0.455 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.178221e-01 0.379 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.721099e-01 0.326 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.721099e-01 0.326 0 0
Signaling by FGFR3 R-HSA-5654741 4.907652e-01 0.309 0 0
PLC beta mediated events R-HSA-112043 4.442258e-01 0.352 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.249088e-01 0.372 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.701602e-01 0.432 0 0
Signaling by TGFB family members R-HSA-9006936 3.706909e-01 0.431 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.771517e-01 0.557 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.877584e-01 0.541 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.350253e-01 0.475 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.573299e-01 0.590 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.075962e-01 0.390 0 0
Killing mechanisms R-HSA-9664420 4.075962e-01 0.390 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.824258e-01 0.317 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.784546e-01 0.320 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.233014e-01 0.373 0 0
GABA receptor activation R-HSA-977443 4.248264e-01 0.372 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.989058e-01 0.302 0 0
Vesicle-mediated transport R-HSA-5653656 3.912403e-01 0.408 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.191144e-01 0.496 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.285671e-01 0.483 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.682511e-01 0.434 0 0
TBC/RABGAPs R-HSA-8854214 4.459324e-01 0.351 0 0
Activation of BH3-only proteins R-HSA-114452 3.682511e-01 0.434 0 0
Ca-dependent events R-HSA-111996 2.973678e-01 0.527 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.721099e-01 0.326 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.285671e-01 0.483 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.678083e-01 0.434 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.988279e-01 0.525 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.687381e-01 0.571 0 0
Gap junction assembly R-HSA-190861 3.496660e-01 0.456 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.709675e-01 0.327 0 0
Frs2-mediated activation R-HSA-170968 2.988279e-01 0.525 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.678083e-01 0.434 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.725451e-01 0.429 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.529405e-01 0.452 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.041862e-01 0.517 0 0
Ion homeostasis R-HSA-5578775 4.651244e-01 0.332 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.452763e-01 0.351 0 0
Parasitic Infection Pathways R-HSA-9824443 4.530655e-01 0.344 0 0
Leishmania infection R-HSA-9658195 4.530655e-01 0.344 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.140938e-01 0.503 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.608761e-01 0.443 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.204008e-01 0.376 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.229242e-01 0.374 0 0
Interferon Signaling R-HSA-913531 2.641390e-01 0.578 0 0
Protein methylation R-HSA-8876725 3.713877e-01 0.430 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.784546e-01 0.320 0 0
Regulation of insulin secretion R-HSA-422356 4.084049e-01 0.389 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.207859e-01 0.494 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.399377e-01 0.469 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.145823e-01 0.382 0 0
DAP12 interactions R-HSA-2172127 4.684426e-01 0.329 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.779640e-01 0.423 0 0
G1/S Transition R-HSA-69206 2.712525e-01 0.567 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.476195e-01 0.459 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.771517e-01 0.557 0 0
Inhibition of PKR R-HSA-169131 2.771517e-01 0.557 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.545312e-01 0.594 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.854402e-01 0.414 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.854402e-01 0.414 0 0
Reelin signalling pathway R-HSA-8866376 3.140938e-01 0.503 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.725451e-01 0.429 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.775115e-01 0.321 0 0
CREB phosphorylation R-HSA-199920 4.288818e-01 0.368 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.189607e-01 0.496 0 0
The NLRP3 inflammasome R-HSA-844456 3.505324e-01 0.455 0 0
Activation of RAC1 R-HSA-428540 4.392060e-01 0.357 0 0
Netrin mediated repulsion signals R-HSA-418886 4.824258e-01 0.317 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.824258e-01 0.317 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.138929e-01 0.383 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.433674e-01 0.353 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.178221e-01 0.379 0 0
Interleukin-17 signaling R-HSA-448424 2.900335e-01 0.538 0 0
Pexophagy R-HSA-9664873 3.529405e-01 0.452 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.511514e-01 0.600 0 0
Muscle contraction R-HSA-397014 3.713180e-01 0.430 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.090342e-01 0.510 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.713877e-01 0.430 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.286576e-01 0.483 0 0
Interleukin-1 signaling R-HSA-9020702 4.540934e-01 0.343 1 1
Somitogenesis R-HSA-9824272 3.599885e-01 0.444 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.900335e-01 0.538 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.022234e-01 0.520 0 0
Signaling by NOTCH1 R-HSA-1980143 3.903628e-01 0.409 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.661494e-01 0.575 0 0
RUNX2 regulates bone development R-HSA-8941326 3.979320e-01 0.400 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.044499e-01 0.516 0 0
CHL1 interactions R-HSA-447041 4.824258e-01 0.317 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.009591e-01 0.521 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.975438e-01 0.303 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.975438e-01 0.303 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.788367e-01 0.555 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.112345e-01 0.386 0 0
Regulation of beta-cell development R-HSA-186712 2.971212e-01 0.527 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.080752e-01 0.389 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.189607e-01 0.496 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.907652e-01 0.309 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.907652e-01 0.309 0 0
Inflammasomes R-HSA-622312 4.741049e-01 0.324 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.854402e-01 0.414 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.090342e-01 0.510 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.090342e-01 0.510 0 0
Josephin domain DUBs R-HSA-5689877 3.529405e-01 0.452 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.288818e-01 0.368 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.964879e-01 0.402 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.433674e-01 0.353 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.224439e-01 0.492 1 0
Signal regulatory protein family interactions R-HSA-391160 3.350253e-01 0.475 0 0
Glucose metabolism R-HSA-70326 4.646862e-01 0.333 0 0
Viral Infection Pathways R-HSA-9824446 3.705919e-01 0.431 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.725451e-01 0.429 0 0
Selenoamino acid metabolism R-HSA-2408522 2.842871e-01 0.546 0 0
Signaling by Interleukins R-HSA-449147 2.822697e-01 0.549 1 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.824258e-01 0.317 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.433674e-01 0.353 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.775115e-01 0.321 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.713877e-01 0.430 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.824258e-01 0.317 0 0
SARS-CoV Infections R-HSA-9679506 3.691350e-01 0.433 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.496660e-01 0.456 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.452763e-01 0.351 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.702268e-01 0.328 0 0
Glucagon-type ligand receptors R-HSA-420092 3.422928e-01 0.466 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.065751e-01 0.295 0 0
Syndecan interactions R-HSA-3000170 5.065751e-01 0.295 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.088225e-01 0.293 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.088225e-01 0.293 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.088225e-01 0.293 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.126475e-01 0.290 0 0
PKA activation R-HSA-163615 5.126475e-01 0.290 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.126475e-01 0.290 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.126475e-01 0.290 0 0
Signaling by TGFBR3 R-HSA-9839373 5.128372e-01 0.290 0 0
Translation R-HSA-72766 5.171999e-01 0.286 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.173675e-01 0.286 0 0
Maturation of nucleoprotein R-HSA-9683610 5.207053e-01 0.283 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.207053e-01 0.283 0 0
Regulation of Apoptosis R-HSA-169911 5.225768e-01 0.282 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.287165e-01 0.277 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.287165e-01 0.277 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.295044e-01 0.276 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.295044e-01 0.276 0 0
Regulation by c-FLIP R-HSA-3371378 5.327496e-01 0.273 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.327496e-01 0.273 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.327496e-01 0.273 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.327496e-01 0.273 0 0
Dimerization of procaspase-8 R-HSA-69416 5.327496e-01 0.273 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.327496e-01 0.273 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.327496e-01 0.273 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.327496e-01 0.273 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.327496e-01 0.273 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.327496e-01 0.273 0 0
Sodium/Proton exchangers R-HSA-425986 5.327496e-01 0.273 0 0
Gastrulation R-HSA-9758941 5.335773e-01 0.273 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.346003e-01 0.272 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.362000e-01 0.271 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.362000e-01 0.271 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.362000e-01 0.271 0 0
Signaling by Hedgehog R-HSA-5358351 5.390534e-01 0.268 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.404002e-01 0.267 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.404002e-01 0.267 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.404002e-01 0.267 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.444502e-01 0.264 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.444502e-01 0.264 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.444502e-01 0.264 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.444502e-01 0.264 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.444502e-01 0.264 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.457714e-01 0.263 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.457714e-01 0.263 0 0
Translesion Synthesis by POLH R-HSA-110320 5.457714e-01 0.263 0 0
Regulation of signaling by CBL R-HSA-912631 5.457714e-01 0.263 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.457714e-01 0.263 0 0
Maturation of nucleoprotein R-HSA-9694631 5.457714e-01 0.263 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.457714e-01 0.263 0 0
Other interleukin signaling R-HSA-449836 5.457714e-01 0.263 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.470252e-01 0.262 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.471293e-01 0.262 0 0
FLT3 signaling in disease R-HSA-9682385 5.471293e-01 0.262 0 0
G1/S-Specific Transcription R-HSA-69205 5.471293e-01 0.262 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.498843e-01 0.260 0 0
Downstream signal transduction R-HSA-186763 5.551339e-01 0.256 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.557934e-01 0.255 0 0
PLC-gamma1 signalling R-HSA-167021 5.557934e-01 0.255 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.557934e-01 0.255 0 0
MET interacts with TNS proteins R-HSA-8875513 5.557934e-01 0.255 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.557934e-01 0.255 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.557934e-01 0.255 0 0
Invadopodia formation R-HSA-8941237 5.557934e-01 0.255 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.557934e-01 0.255 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.557934e-01 0.255 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.557934e-01 0.255 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 5.557934e-01 0.255 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 5.557934e-01 0.255 0 0
MET activates STAT3 R-HSA-8875791 5.557934e-01 0.255 0 0
Intracellular oxygen transport R-HSA-8981607 5.557934e-01 0.255 0 0
The NLRP1 inflammasome R-HSA-844455 5.557934e-01 0.255 0 0
FasL/ CD95L signaling R-HSA-75157 5.557934e-01 0.255 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.589572e-01 0.253 0 0
Regulation of KIT signaling R-HSA-1433559 5.589572e-01 0.253 0 0
Malate-aspartate shuttle R-HSA-9856872 5.589572e-01 0.253 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.589572e-01 0.253 0 0
Aquaporin-mediated transport R-HSA-445717 5.636477e-01 0.249 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.649812e-01 0.248 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.649812e-01 0.248 0 0
Signaling by FGFR2 R-HSA-5654738 5.652290e-01 0.248 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.671966e-01 0.246 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.699186e-01 0.244 0 0
Degradation of AXIN R-HSA-4641257 5.711305e-01 0.243 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.711305e-01 0.243 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.711305e-01 0.243 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.772149e-01 0.239 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.776855e-01 0.238 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.776855e-01 0.238 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.776855e-01 0.238 0 0
Formation of definitive endoderm R-HSA-9823730 5.776855e-01 0.238 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.796163e-01 0.237 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.796163e-01 0.237 0 0
CASP8 activity is inhibited R-HSA-5218900 5.796163e-01 0.237 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.796163e-01 0.237 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.796163e-01 0.237 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.796163e-01 0.237 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.796163e-01 0.237 0 0
Interleukin-1 processing R-HSA-448706 5.796163e-01 0.237 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.796163e-01 0.237 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.796163e-01 0.237 0 0
G0 and Early G1 R-HSA-1538133 5.808449e-01 0.236 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.808449e-01 0.236 0 0
Mitochondrial protein import R-HSA-1268020 5.825152e-01 0.235 0 0
Signaling by SCF-KIT R-HSA-1433557 5.850834e-01 0.233 0 0
Cilium Assembly R-HSA-5617833 5.861821e-01 0.232 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.877290e-01 0.231 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.895677e-01 0.229 0 0
HIV Infection R-HSA-162906 5.898712e-01 0.229 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.928224e-01 0.227 0 0
MET activates PTK2 signaling R-HSA-8874081 5.928224e-01 0.227 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.928224e-01 0.227 0 0
TRP channels R-HSA-3295583 5.928224e-01 0.227 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.953048e-01 0.225 0 0
Erythropoietin activates RAS R-HSA-9027284 5.953048e-01 0.225 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.953048e-01 0.225 0 0
p38MAPK events R-HSA-171007 5.953048e-01 0.225 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.953048e-01 0.225 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.953048e-01 0.225 0 0
p75NTR signals via NF-kB R-HSA-193639 5.953048e-01 0.225 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.953048e-01 0.225 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.953048e-01 0.225 0 0
Toll-like Receptor Cascades R-HSA-168898 5.970005e-01 0.224 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.057791e-01 0.218 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.057791e-01 0.218 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.057791e-01 0.218 0 0
Proteasome assembly R-HSA-9907900 6.066306e-01 0.217 0 0
Signalling to RAS R-HSA-167044 6.082802e-01 0.216 0 0
Basigin interactions R-HSA-210991 6.082802e-01 0.216 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.082802e-01 0.216 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.082802e-01 0.216 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.082802e-01 0.216 0 0
COPII-mediated vesicle transport R-HSA-204005 6.115563e-01 0.214 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.175647e-01 0.209 0 0
Ion transport by P-type ATPases R-HSA-936837 6.191316e-01 0.208 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.191316e-01 0.208 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.196457e-01 0.208 0 0
Cristae formation R-HSA-8949613 6.196457e-01 0.208 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.196457e-01 0.208 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.223505e-01 0.206 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.223505e-01 0.206 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.223505e-01 0.206 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 6.223505e-01 0.206 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.223505e-01 0.206 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.223505e-01 0.206 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.223505e-01 0.206 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 6.223505e-01 0.206 0 0
Dopamine receptors R-HSA-390651 6.223505e-01 0.206 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 6.223505e-01 0.206 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.229322e-01 0.206 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.229322e-01 0.206 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.229322e-01 0.206 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.229322e-01 0.206 0 0
PI3K/AKT activation R-HSA-198203 6.229322e-01 0.206 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.229322e-01 0.206 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.229322e-01 0.206 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.229322e-01 0.206 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.229322e-01 0.206 0 0
Dual incision in TC-NER R-HSA-6782135 6.275712e-01 0.202 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.275898e-01 0.202 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.286988e-01 0.202 0 0
Hedgehog 'on' state R-HSA-5632684 6.286988e-01 0.202 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.296407e-01 0.201 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.296407e-01 0.201 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.296407e-01 0.201 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.296407e-01 0.201 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.296407e-01 0.201 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.298784e-01 0.201 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.298784e-01 0.201 0 0
MHC class II antigen presentation R-HSA-2132295 6.323046e-01 0.199 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.370769e-01 0.196 0 0
Rab regulation of trafficking R-HSA-9007101 6.374436e-01 0.196 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.374746e-01 0.196 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.374746e-01 0.196 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.374746e-01 0.196 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.392473e-01 0.194 0 0
Leishmania phagocytosis R-HSA-9664417 6.426248e-01 0.192 0 0
Parasite infection R-HSA-9664407 6.426248e-01 0.192 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.426248e-01 0.192 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.453903e-01 0.190 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.453903e-01 0.190 0 0
Pyroptosis R-HSA-5620971 6.453903e-01 0.190 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.453903e-01 0.190 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.454504e-01 0.190 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.530959e-01 0.185 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.560321e-01 0.183 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.560321e-01 0.183 0 0
Transmission across Chemical Synapses R-HSA-112315 6.591091e-01 0.181 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.605067e-01 0.180 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.605067e-01 0.180 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.611786e-01 0.180 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.611786e-01 0.180 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.619054e-01 0.179 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.619054e-01 0.179 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.619054e-01 0.179 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.619054e-01 0.179 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.619054e-01 0.179 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.619054e-01 0.179 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.620902e-01 0.179 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.627091e-01 0.179 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.627091e-01 0.179 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.627091e-01 0.179 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.627091e-01 0.179 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.627091e-01 0.179 0 0
Formation of the posterior neural plate R-HSA-9832991 6.627091e-01 0.179 0 0
Synthesis of PI R-HSA-1483226 6.627091e-01 0.179 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.627091e-01 0.179 0 0
Signaling by APC mutants R-HSA-4839744 6.627091e-01 0.179 0 0
Suppression of apoptosis R-HSA-9635465 6.627091e-01 0.179 0 0
Interleukin-2 signaling R-HSA-9020558 6.627091e-01 0.179 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.652135e-01 0.177 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.652135e-01 0.177 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.676069e-01 0.175 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.700113e-01 0.174 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.700113e-01 0.174 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.700113e-01 0.174 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.700113e-01 0.174 0 0
Kidney development R-HSA-9830369 6.708623e-01 0.173 0 0
Integration of energy metabolism R-HSA-163685 6.711584e-01 0.173 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.753955e-01 0.170 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.753955e-01 0.170 0 0
Adipogenesis R-HSA-9843745 6.764751e-01 0.170 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.775159e-01 0.169 0 0
Activation of AMPA receptors R-HSA-399710 6.789384e-01 0.168 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.789384e-01 0.168 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.789384e-01 0.168 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.789384e-01 0.168 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.789384e-01 0.168 0 0
PTK6 Down-Regulation R-HSA-8849472 6.789384e-01 0.168 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.789384e-01 0.168 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.789384e-01 0.168 0 0
Inositol transporters R-HSA-429593 6.789384e-01 0.168 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.789384e-01 0.168 0 0
Co-inhibition by BTLA R-HSA-9927353 6.789384e-01 0.168 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.789384e-01 0.168 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.789384e-01 0.168 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.789384e-01 0.168 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.789384e-01 0.168 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.789384e-01 0.168 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.809200e-01 0.167 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.809877e-01 0.167 0 0
Co-stimulation by CD28 R-HSA-389356 6.866110e-01 0.163 0 0
Regulated Necrosis R-HSA-5218859 6.871701e-01 0.163 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.914649e-01 0.160 0 0
Growth hormone receptor signaling R-HSA-982772 6.914649e-01 0.160 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.920795e-01 0.160 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.920795e-01 0.160 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.920795e-01 0.160 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.920795e-01 0.160 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.920795e-01 0.160 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.934786e-01 0.159 0 0
Interleukin-37 signaling R-HSA-9008059 6.934786e-01 0.159 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.967513e-01 0.157 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.976425e-01 0.156 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.990349e-01 0.156 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.990349e-01 0.156 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.990349e-01 0.156 0 0
ERKs are inactivated R-HSA-202670 6.990349e-01 0.156 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.990349e-01 0.156 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.990349e-01 0.156 0 0
NF-kB is activated and signals survival R-HSA-209560 6.990349e-01 0.156 0 0
Signaling by AXIN mutants R-HSA-4839735 6.990349e-01 0.156 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.990349e-01 0.156 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.996433e-01 0.155 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.006684e-01 0.154 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.006684e-01 0.154 0 0
FOXO-mediated transcription R-HSA-9614085 7.021584e-01 0.154 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.093322e-01 0.149 0 0
Signaling by FGFR1 R-HSA-5654736 7.093322e-01 0.149 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.132615e-01 0.147 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.138097e-01 0.146 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.195335e-01 0.143 0 0
Apoptotic factor-mediated response R-HSA-111471 7.201759e-01 0.143 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.201759e-01 0.143 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 7.270498e-01 0.138 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.270498e-01 0.138 0 0
Cam-PDE 1 activation R-HSA-111957 7.270498e-01 0.138 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.270498e-01 0.138 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.270498e-01 0.138 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.270498e-01 0.138 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.270498e-01 0.138 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 7.270498e-01 0.138 0 0
Signaling by MAPK mutants R-HSA-9652817 7.270498e-01 0.138 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 7.270498e-01 0.138 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.270498e-01 0.138 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.270498e-01 0.138 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 7.270498e-01 0.138 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.270498e-01 0.138 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 7.270498e-01 0.138 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.270498e-01 0.138 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.270498e-01 0.138 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.270498e-01 0.138 0 0
TRAIL signaling R-HSA-75158 7.270498e-01 0.138 0 0
MET activates RAS signaling R-HSA-8851805 7.320507e-01 0.135 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.320507e-01 0.135 0 0
Polymerase switching R-HSA-69091 7.320507e-01 0.135 0 0
Leading Strand Synthesis R-HSA-69109 7.320507e-01 0.135 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.320507e-01 0.135 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.320507e-01 0.135 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.320507e-01 0.135 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.320507e-01 0.135 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.320507e-01 0.135 0 0
Regulation of IFNG signaling R-HSA-877312 7.320507e-01 0.135 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.330863e-01 0.135 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.330863e-01 0.135 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.365723e-01 0.133 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.368951e-01 0.133 0 0
G1 Phase R-HSA-69236 7.375743e-01 0.132 0 0
Cyclin D associated events in G1 R-HSA-69231 7.375743e-01 0.132 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.375743e-01 0.132 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.394736e-01 0.131 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.394736e-01 0.131 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.394736e-01 0.131 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.417475e-01 0.130 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.462343e-01 0.127 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.462343e-01 0.127 0 0
Rap1 signalling R-HSA-392517 7.462343e-01 0.127 0 0
Specification of the neural plate border R-HSA-9834899 7.462343e-01 0.127 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.462343e-01 0.127 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.462343e-01 0.127 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.473604e-01 0.126 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.532238e-01 0.123 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.547874e-01 0.122 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.550283e-01 0.122 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.550283e-01 0.122 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.555560e-01 0.122 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.556777e-01 0.122 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.568440e-01 0.121 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.612556e-01 0.118 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.619327e-01 0.118 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.619327e-01 0.118 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.619327e-01 0.118 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.619327e-01 0.118 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.619327e-01 0.118 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.619327e-01 0.118 0 0
Processing of SMDT1 R-HSA-8949664 7.619327e-01 0.118 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.619327e-01 0.118 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.619327e-01 0.118 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.646262e-01 0.117 0 0
HIV Life Cycle R-HSA-162587 7.646262e-01 0.117 0 0
TCR signaling R-HSA-202403 7.665028e-01 0.115 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.679539e-01 0.115 0 0
Signaling by LTK in cancer R-HSA-9842640 7.679539e-01 0.115 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.679539e-01 0.115 0 0
STAT5 Activation R-HSA-9645135 7.679539e-01 0.115 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 7.679539e-01 0.115 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 7.679539e-01 0.115 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.679539e-01 0.115 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 7.679539e-01 0.115 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.679539e-01 0.115 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.679539e-01 0.115 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 7.679539e-01 0.115 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.679539e-01 0.115 0 0
MET Receptor Activation R-HSA-6806942 7.679539e-01 0.115 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.679539e-01 0.115 0 0
Neurofascin interactions R-HSA-447043 7.679539e-01 0.115 0 0
Abacavir transmembrane transport R-HSA-2161517 7.679539e-01 0.115 0 0
Metabolism of vitamin K R-HSA-6806664 7.679539e-01 0.115 0 0
Leukotriene receptors R-HSA-391906 7.679539e-01 0.115 0 0
Signaling by NODAL R-HSA-1181150 7.703146e-01 0.113 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.703146e-01 0.113 0 0
Protein hydroxylation R-HSA-9629569 7.703146e-01 0.113 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.711751e-01 0.113 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.716045e-01 0.113 0 0
Diseases of Immune System R-HSA-5260271 7.725204e-01 0.112 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.725204e-01 0.112 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.743360e-01 0.111 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.756357e-01 0.110 0 0
Interleukin-1 family signaling R-HSA-446652 7.793981e-01 0.108 1 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.815942e-01 0.107 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.815942e-01 0.107 0 0
Insulin processing R-HSA-264876 7.815942e-01 0.107 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.888784e-01 0.103 0 0
Removal of the Flap Intermediate R-HSA-69166 7.888784e-01 0.103 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.888784e-01 0.103 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.888784e-01 0.103 0 0
Physiological factors R-HSA-5578768 7.888784e-01 0.103 0 0
Prolactin receptor signaling R-HSA-1170546 7.888784e-01 0.103 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.888784e-01 0.103 0 0
FLT3 Signaling R-HSA-9607240 7.890604e-01 0.103 0 0
Lagging Strand Synthesis R-HSA-69186 7.924927e-01 0.101 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.924927e-01 0.101 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.924927e-01 0.101 0 0
Signaling by NOTCH2 R-HSA-1980145 7.932917e-01 0.101 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.932917e-01 0.101 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.932917e-01 0.101 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.932917e-01 0.101 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.989063e-01 0.098 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.998933e-01 0.097 0 0
Telomere Extension By Telomerase R-HSA-171319 8.005311e-01 0.097 0 0
Insulin receptor recycling R-HSA-77387 8.005311e-01 0.097 0 0
Gluconeogenesis R-HSA-70263 8.015052e-01 0.096 0 0
IFNG signaling activates MAPKs R-HSA-9732724 8.027302e-01 0.095 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 8.027302e-01 0.095 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.027302e-01 0.095 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.027302e-01 0.095 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 8.027302e-01 0.095 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.027302e-01 0.095 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 8.027302e-01 0.095 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 8.027302e-01 0.095 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.027302e-01 0.095 0 0
Cysteine formation from homocysteine R-HSA-1614603 8.027302e-01 0.095 0 0
Reuptake of GABA R-HSA-888593 8.027302e-01 0.095 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.027302e-01 0.095 0 0
VLDL clearance R-HSA-8964046 8.027302e-01 0.095 0 0
Regulation of PTEN localization R-HSA-8948747 8.027302e-01 0.095 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.027302e-01 0.095 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 8.027302e-01 0.095 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.027302e-01 0.095 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.046653e-01 0.094 0 0
PPARA activates gene expression R-HSA-1989781 8.052864e-01 0.094 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.088786e-01 0.092 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.098401e-01 0.092 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.098401e-01 0.092 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.108786e-01 0.091 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.109606e-01 0.091 0 0
Ribavirin ADME R-HSA-9755088 8.128558e-01 0.090 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.130277e-01 0.090 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.130969e-01 0.090 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.130969e-01 0.090 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.130969e-01 0.090 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.130969e-01 0.090 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.130969e-01 0.090 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.130969e-01 0.090 0 0
Translesion synthesis by REV1 R-HSA-110312 8.130969e-01 0.090 0 0
Signaling by Activin R-HSA-1502540 8.130969e-01 0.090 0 0
Formation of the anterior neural plate R-HSA-9823739 8.130969e-01 0.090 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.153764e-01 0.089 0 0
mRNA Capping R-HSA-72086 8.181155e-01 0.087 0 0
DARPP-32 events R-HSA-180024 8.181155e-01 0.087 0 0
IGF1R signaling cascade R-HSA-2428924 8.237054e-01 0.084 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.258845e-01 0.083 0 0
Platelet degranulation R-HSA-114608 8.285572e-01 0.082 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.314990e-01 0.080 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.314990e-01 0.080 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.314990e-01 0.080 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.314990e-01 0.080 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.314990e-01 0.080 0 0
RSK activation R-HSA-444257 8.322963e-01 0.080 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.322963e-01 0.080 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.322963e-01 0.080 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.322963e-01 0.080 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.322963e-01 0.080 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.322963e-01 0.080 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.322963e-01 0.080 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.322963e-01 0.080 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 8.322963e-01 0.080 0 0
Adrenoceptors R-HSA-390696 8.322963e-01 0.080 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.326786e-01 0.080 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.336164e-01 0.079 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.344028e-01 0.079 0 0
Translesion synthesis by POLI R-HSA-5656121 8.348001e-01 0.078 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.348001e-01 0.078 0 0
Fructose catabolism R-HSA-70350 8.348001e-01 0.078 0 0
Differentiation of T cells R-HSA-9945266 8.348001e-01 0.078 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.348001e-01 0.078 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.351919e-01 0.078 0 0
Collagen chain trimerization R-HSA-8948216 8.397516e-01 0.076 0 0
Adaptive Immune System R-HSA-1280218 8.399267e-01 0.076 0 0
Hemostasis R-HSA-109582 8.410946e-01 0.075 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.411022e-01 0.075 0 0
Signaling by FGFR R-HSA-190236 8.416523e-01 0.075 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.485222e-01 0.071 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.485222e-01 0.071 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.485222e-01 0.071 0 0
Formation of the ureteric bud R-HSA-9830674 8.485222e-01 0.071 0 0
Extension of Telomeres R-HSA-180786 8.488906e-01 0.071 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.488906e-01 0.071 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.494525e-01 0.071 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.494525e-01 0.071 0 0
Signaling by FGFR in disease R-HSA-1226099 8.541195e-01 0.068 0 0
Translesion synthesis by POLK R-HSA-5655862 8.541978e-01 0.068 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.541978e-01 0.068 0 0
Coenzyme A biosynthesis R-HSA-196783 8.541978e-01 0.068 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.574326e-01 0.067 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.574326e-01 0.067 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.574326e-01 0.067 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.574326e-01 0.067 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.574326e-01 0.067 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.574326e-01 0.067 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.574326e-01 0.067 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.574326e-01 0.067 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.574326e-01 0.067 0 0
RAB geranylgeranylation R-HSA-8873719 8.595484e-01 0.066 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.635951e-01 0.064 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.640279e-01 0.063 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.640279e-01 0.063 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.656821e-01 0.063 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.677047e-01 0.062 0 0
ER-Phagosome pathway R-HSA-1236974 8.688491e-01 0.061 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.714936e-01 0.060 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.714936e-01 0.060 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.714936e-01 0.060 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.714936e-01 0.060 0 0
Cardiogenesis R-HSA-9733709 8.760914e-01 0.057 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.767187e-01 0.057 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.772635e-01 0.057 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.772635e-01 0.057 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.772635e-01 0.057 0 0
Tight junction interactions R-HSA-420029 8.781186e-01 0.056 0 0
Formation of the nephric duct R-HSA-9830364 8.781186e-01 0.056 0 0
Neutrophil degranulation R-HSA-6798695 8.784508e-01 0.056 0 0
OADH complex synthesizes glutaryl-CoA from 2-OA R-HSA-9858328 8.788026e-01 0.056 0 0
DNA replication initiation R-HSA-68952 8.788026e-01 0.056 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.788026e-01 0.056 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.788026e-01 0.056 0 0
Interleukin-27 signaling R-HSA-9020956 8.788026e-01 0.056 0 0
Maturation of spike protein R-HSA-9683686 8.788026e-01 0.056 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.790382e-01 0.056 0 0
Signaling by PDGF R-HSA-186797 8.790382e-01 0.056 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.800830e-01 0.055 0 0
Synthesis of PC R-HSA-1483191 8.800830e-01 0.055 0 0
Protein localization R-HSA-9609507 8.866338e-01 0.052 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.868816e-01 0.052 0 0
Tie2 Signaling R-HSA-210993 8.868816e-01 0.052 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.868816e-01 0.052 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.878099e-01 0.052 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.908959e-01 0.050 0 0
Urea cycle R-HSA-70635 8.908959e-01 0.050 0 0
LGI-ADAM interactions R-HSA-5682910 8.969704e-01 0.047 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.969704e-01 0.047 0 0
vRNP Assembly R-HSA-192905 8.969704e-01 0.047 0 0
vRNA Synthesis R-HSA-192814 8.969704e-01 0.047 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 8.969704e-01 0.047 0 0
Bicarbonate transporters R-HSA-425381 8.969704e-01 0.047 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.969704e-01 0.047 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.969704e-01 0.047 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.969704e-01 0.047 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.969704e-01 0.047 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.969704e-01 0.047 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.978880e-01 0.047 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.985477e-01 0.046 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.005450e-01 0.045 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.005450e-01 0.045 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.005450e-01 0.045 0 0
Pyrimidine biosynthesis R-HSA-500753 9.005450e-01 0.045 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.005450e-01 0.045 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.024587e-01 0.045 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.024587e-01 0.045 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.070238e-01 0.042 0 0
tRNA processing R-HSA-72306 9.077207e-01 0.042 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.090934e-01 0.041 0 0
DS-GAG biosynthesis R-HSA-2022923 9.124156e-01 0.040 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.124156e-01 0.040 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 9.124156e-01 0.040 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.124156e-01 0.040 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.124156e-01 0.040 0 0
Anchoring fibril formation R-HSA-2214320 9.124156e-01 0.040 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 9.124156e-01 0.040 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.126550e-01 0.040 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.126550e-01 0.040 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.129024e-01 0.040 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.129024e-01 0.040 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.154366e-01 0.038 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.174586e-01 0.037 0 0
PI Metabolism R-HSA-1483255 9.207539e-01 0.036 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.223186e-01 0.035 0 0
Platelet calcium homeostasis R-HSA-418360 9.223186e-01 0.035 0 0
Post-translational protein modification R-HSA-597592 9.227606e-01 0.035 0 0
tRNA Aminoacylation R-HSA-379724 9.232111e-01 0.035 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.233702e-01 0.035 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.233702e-01 0.035 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.233702e-01 0.035 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.255462e-01 0.034 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.255462e-01 0.034 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.255462e-01 0.034 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.255462e-01 0.034 0 0
Interleukin-15 signaling R-HSA-8983432 9.255462e-01 0.034 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.255462e-01 0.034 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.255462e-01 0.034 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.255462e-01 0.034 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.255462e-01 0.034 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.255462e-01 0.034 0 0
Estrogen biosynthesis R-HSA-193144 9.255462e-01 0.034 0 0
Interleukin-35 Signalling R-HSA-8984722 9.255462e-01 0.034 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.255462e-01 0.034 0 0
OAS antiviral response R-HSA-8983711 9.255462e-01 0.034 0 0
Neuronal System R-HSA-112316 9.315694e-01 0.031 0 0
CS-GAG biosynthesis R-HSA-2022870 9.328366e-01 0.030 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.328366e-01 0.030 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.328366e-01 0.030 0 0
Serine metabolism R-HSA-977347 9.328366e-01 0.030 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.329469e-01 0.030 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 9.367090e-01 0.028 0 0
Interleukin-6 signaling R-HSA-1059683 9.367090e-01 0.028 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.367810e-01 0.028 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.367810e-01 0.028 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.384102e-01 0.028 0 0
Budding and maturation of HIV virion R-HSA-162588 9.384102e-01 0.028 0 0
Cargo concentration in the ER R-HSA-5694530 9.384102e-01 0.028 0 0
Pentose phosphate pathway R-HSA-71336 9.397055e-01 0.027 0 0
Infectious disease R-HSA-5663205 9.399670e-01 0.027 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.411876e-01 0.026 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.411876e-01 0.026 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.411876e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.411876e-01 0.026 0 0
Signaling by KIT in disease R-HSA-9669938 9.411876e-01 0.026 0 0
Ethanol oxidation R-HSA-71384 9.411876e-01 0.026 0 0
LDL clearance R-HSA-8964038 9.411876e-01 0.026 0 0
Neddylation R-HSA-8951664 9.441122e-01 0.025 0 0
Interferon gamma signaling R-HSA-877300 9.444471e-01 0.025 0 0
Insulin receptor signalling cascade R-HSA-74751 9.458183e-01 0.024 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.461986e-01 0.024 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.461986e-01 0.024 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.461986e-01 0.024 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.461986e-01 0.024 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.461986e-01 0.024 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.461986e-01 0.024 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.461986e-01 0.024 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.461986e-01 0.024 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.461986e-01 0.024 0 0
Zinc transporters R-HSA-435354 9.461986e-01 0.024 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.463142e-01 0.024 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.463142e-01 0.024 0 0
Intraflagellar transport R-HSA-5620924 9.481858e-01 0.023 0 0
Mitochondrial protein degradation R-HSA-9837999 9.484839e-01 0.023 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.485450e-01 0.023 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.485450e-01 0.023 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.542659e-01 0.020 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.542659e-01 0.020 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.542659e-01 0.020 0 0
Protein lipoylation R-HSA-9857492 9.542659e-01 0.020 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.542659e-01 0.020 0 0
Transport and metabolism of PAPS R-HSA-174362 9.542659e-01 0.020 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.542659e-01 0.020 0 0
DNA Damage Reversal R-HSA-73942 9.542659e-01 0.020 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.550188e-01 0.020 0 0
Complex III assembly R-HSA-9865881 9.550188e-01 0.020 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.564215e-01 0.019 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.564215e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.564215e-01 0.019 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.568465e-01 0.019 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.573515e-01 0.019 0 0
Azathioprine ADME R-HSA-9748787 9.576922e-01 0.019 0 0
Iron uptake and transport R-HSA-917937 9.581814e-01 0.019 0 0
G alpha (s) signalling events R-HSA-418555 9.604701e-01 0.018 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.607085e-01 0.017 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.607085e-01 0.017 0 0
Hyaluronan degradation R-HSA-2160916 9.607085e-01 0.017 0 0
Laminin interactions R-HSA-3000157 9.607085e-01 0.017 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.611239e-01 0.017 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.611239e-01 0.017 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.611239e-01 0.017 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.611239e-01 0.017 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.611239e-01 0.017 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.611239e-01 0.017 0 0
Activation of SMO R-HSA-5635838 9.611239e-01 0.017 0 0
Attachment and Entry R-HSA-9678110 9.611239e-01 0.017 0 0
Atorvastatin ADME R-HSA-9754706 9.611239e-01 0.017 0 0
Negative regulation of FLT3 R-HSA-9706369 9.611239e-01 0.017 0 0
Virus Assembly and Release R-HSA-168268 9.611239e-01 0.017 0 0
Hyaluronan metabolism R-HSA-2142845 9.617426e-01 0.017 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.620705e-01 0.017 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.635202e-01 0.016 0 0
Metabolism of polyamines R-HSA-351202 9.635202e-01 0.016 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.657038e-01 0.015 0 0
Abacavir ADME R-HSA-2161522 9.657038e-01 0.015 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.661126e-01 0.015 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.661126e-01 0.015 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.669225e-01 0.015 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.669538e-01 0.015 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.669538e-01 0.015 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.669538e-01 0.015 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.669538e-01 0.015 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.669538e-01 0.015 0 0
Heme assimilation R-HSA-9927020 9.669538e-01 0.015 0 0
Glycine degradation R-HSA-6783984 9.669538e-01 0.015 0 0
Fibronectin matrix formation R-HSA-1566977 9.669538e-01 0.015 0 0
Synthesis of PG R-HSA-1483148 9.669538e-01 0.015 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.669538e-01 0.015 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.669538e-01 0.015 0 0
Signaling by Insulin receptor R-HSA-74752 9.675222e-01 0.014 0 0
ABC transporter disorders R-HSA-5619084 9.679196e-01 0.014 0 0
Nucleotide biosynthesis R-HSA-8956320 9.689890e-01 0.014 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.700083e-01 0.013 0 0
Glycosphingolipid transport R-HSA-9845576 9.700083e-01 0.013 0 0
Triglyceride catabolism R-HSA-163560 9.700083e-01 0.013 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.700848e-01 0.013 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.700848e-01 0.013 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.700848e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.700848e-01 0.013 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.700848e-01 0.013 0 0
Triglyceride biosynthesis R-HSA-75109 9.700848e-01 0.013 0 0
Synthesis of PE R-HSA-1483213 9.700848e-01 0.013 0 0
ABC-family proteins mediated transport R-HSA-382556 9.702203e-01 0.013 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.719098e-01 0.012 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.719098e-01 0.012 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.719098e-01 0.012 0 0
Choline catabolism R-HSA-6798163 9.719098e-01 0.012 0 0
Developmental Cell Lineages R-HSA-9734767 9.723748e-01 0.012 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.725101e-01 0.012 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.734774e-01 0.012 0 0
Metabolism of folate and pterines R-HSA-196757 9.734774e-01 0.012 0 0
HIV elongation arrest and recovery R-HSA-167287 9.739235e-01 0.011 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.739235e-01 0.011 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.759102e-01 0.011 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.761228e-01 0.010 0 0
Platelet sensitization by LDL R-HSA-432142 9.761228e-01 0.010 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.772839e-01 0.010 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.772839e-01 0.010 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.784378e-01 0.009 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.784523e-01 0.009 0 0
Signaling by ERBB4 R-HSA-1236394 9.786237e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.790610e-01 0.009 0 0
Cardiac conduction R-HSA-5576891 9.792317e-01 0.009 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.793055e-01 0.009 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.793055e-01 0.009 0 0
Ion channel transport R-HSA-983712 9.795467e-01 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.796755e-01 0.009 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.797041e-01 0.009 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.797041e-01 0.009 0 0
Diseases of hemostasis R-HSA-9671793 9.797041e-01 0.009 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.797041e-01 0.009 0 0
Transport of nucleotide sugars R-HSA-727802 9.797041e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.799623e-01 0.009 0 0
Metal ion SLC transporters R-HSA-425410 9.801904e-01 0.009 0 0
RSV-host interactions R-HSA-9833110 9.802576e-01 0.009 0 0
Metabolism of proteins R-HSA-392499 9.816149e-01 0.008 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.817399e-01 0.008 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.817399e-01 0.008 0 0
HIV Transcription Elongation R-HSA-167169 9.817399e-01 0.008 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.817399e-01 0.008 0 0
Interleukin-2 family signaling R-HSA-451927 9.817399e-01 0.008 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.827484e-01 0.008 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.827484e-01 0.008 0 0
Keratan sulfate degradation R-HSA-2022857 9.827484e-01 0.008 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.827484e-01 0.008 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.827484e-01 0.008 0 0
Pregnenolone biosynthesis R-HSA-196108 9.827484e-01 0.008 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.827484e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.827920e-01 0.008 0 0
Platelet homeostasis R-HSA-418346 9.833225e-01 0.007 0 0
Transcription of the HIV genome R-HSA-167172 9.836869e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.836939e-01 0.007 0 0
Triglyceride metabolism R-HSA-8979227 9.836939e-01 0.007 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.838991e-01 0.007 0 0
Maturation of spike protein R-HSA-9694548 9.838991e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9694635 9.840602e-01 0.007 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.842960e-01 0.007 0 0
PI3K Cascade R-HSA-109704 9.842960e-01 0.007 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.853362e-01 0.006 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.853362e-01 0.006 0 0
Abacavir metabolism R-HSA-2161541 9.853362e-01 0.006 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.853362e-01 0.006 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.853362e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.853880e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.855651e-01 0.006 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.858124e-01 0.006 0 0
HIV Transcription Initiation R-HSA-167161 9.858124e-01 0.006 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.858124e-01 0.006 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.865956e-01 0.006 0 0
Collagen formation R-HSA-1474290 9.867041e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.869151e-01 0.006 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.875063e-01 0.005 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.875360e-01 0.005 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.875360e-01 0.005 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.875360e-01 0.005 0 0
Attachment and Entry R-HSA-9694614 9.875360e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.875633e-01 0.005 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.880613e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.887002e-01 0.005 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.890049e-01 0.005 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.894059e-01 0.005 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.894059e-01 0.005 0 0
Cellular hexose transport R-HSA-189200 9.894059e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.900847e-01 0.004 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.901881e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.901881e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.901881e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.903295e-01 0.004 0 0
Methylation R-HSA-156581 9.903295e-01 0.004 0 0
Downstream TCR signaling R-HSA-202424 9.905405e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.905405e-01 0.004 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.909953e-01 0.004 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.909953e-01 0.004 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.909953e-01 0.004 0 0
Carnitine shuttle R-HSA-200425 9.909953e-01 0.004 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.909953e-01 0.004 0 0
Interleukin-20 family signaling R-HSA-8854691 9.909953e-01 0.004 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.914995e-01 0.004 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.923464e-01 0.003 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.923464e-01 0.003 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.923464e-01 0.003 0 0
Interleukin-6 family signaling R-HSA-6783589 9.923464e-01 0.003 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.925321e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.925321e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.926119e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.926119e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.931783e-01 0.003 0 0
IRS-mediated signalling R-HSA-112399 9.931783e-01 0.003 0 0
Stimuli-sensing channels R-HSA-2672351 9.933759e-01 0.003 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.934948e-01 0.003 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.934948e-01 0.003 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.934948e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.934948e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.935932e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.936670e-01 0.003 0 0
Immune System R-HSA-168256 9.937093e-01 0.003 1 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.940647e-01 0.003 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.944464e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.944464e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.944464e-01 0.002 0 0
Sphingolipid catabolism R-HSA-9845614 9.944709e-01 0.002 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.944709e-01 0.002 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.944709e-01 0.002 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.944709e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.947257e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.949527e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.949527e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.949738e-01 0.002 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.953007e-01 0.002 0 0
Signaling by BMP R-HSA-201451 9.953007e-01 0.002 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.953007e-01 0.002 0 0
Potassium Channels R-HSA-1296071 9.957603e-01 0.002 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.960059e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.960059e-01 0.002 0 0
Pyrimidine salvage R-HSA-73614 9.960059e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.961226e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.961226e-01 0.002 0 0
Intra-Golgi traffic R-HSA-6811438 9.968764e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.968764e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.968764e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.970129e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.970525e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.971149e-01 0.001 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.971149e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.972771e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.973818e-01 0.001 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.975479e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.975578e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.979468e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.979786e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.980238e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.981703e-01 0.001 0 0
Keratan sulfate biosynthesis R-HSA-2022854 9.982288e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.982288e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.982526e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.984947e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.984947e-01 0.001 0 0
Heme degradation R-HSA-189483 9.984947e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.986733e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.986955e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.987207e-01 0.001 0 0
eNOS activation R-HSA-203615 9.987207e-01 0.001 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.987207e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.987207e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.988119e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.989128e-01 0.000 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.989128e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.990999e-01 0.000 0 0
Voltage gated Potassium channels R-HSA-1296072 9.992148e-01 0.000 0 0
Lysine catabolism R-HSA-71064 9.992148e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.992148e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.992148e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.992753e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.993327e-01 0.000 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.994329e-01 0.000 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.995181e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.995181e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.995181e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.995989e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.996023e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996876e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.997021e-01 0.000 0 0
Disease R-HSA-1643685 9.997452e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997459e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997459e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997790e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.997864e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.998185e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.998572e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998626e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998722e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998784e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998818e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.998887e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.999054e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.999054e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999087e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.999196e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999197e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999320e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999334e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999334e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999334e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999427e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999431e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999503e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999556e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999576e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999595e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999666e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999715e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999731e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999736e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999736e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999778e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999810e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999814e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999840e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999842e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999866e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999866e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999874e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999889e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999918e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999920e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999953e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999967e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999969e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999974e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999974e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999974e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999981e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999984e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999986e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999993e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 1.000000e+00 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways