PKCE

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14493 S194 GPS6 CLDN4 CPER CPETR1 WBSCR8 LLLGGGLLCCNCPPRtDKPYsAKYSAARsAAAsNyV_____
O14493 T189 GPS6 CLDN4 CPER CPETR1 WBSCR8 AASGLLLLGGGLLCCNCPPRtDKPYsAKYSAARsAAAsNyV
O14649 T383 SIGNOR|PSP KCNK3 TASK TASK1 CSGAPRSAIssVsTGLHSLStFRGLMKRRssV_________
O14920 S177 PSP IKBKB IKKB EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O60716 S268 SIGNOR|PSP CTNND1 KIAA0384 yRAPsRQDVyGPQPQVRVGGssVDLHRFHPEPyGLEDDQRs
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O75689 S87 SIGNOR|iPTMNet|PSP ADAP1 CENTA1 EAQVEFMASHGNDAARARFEsKVPSFYYRPTPSDCQLLREQ
O75689 T276 SIGNOR|iPTMNet|PSP ADAP1 CENTA1 EGYMEKTGPKQTEGFRKRWFtMDDRRLMYFKDPLDAFARGE
O94925 S314 SIGNOR|PSP GLS GLS1 KIAA0838 AIAVNDLGTEyVHRYVGKEPsGLRFNKLFLNEDDKPHNPMV
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00533 T678 PSP EGFR ERBB ERBB1 HER1 LVVALGIGLFMRRRHIVRKRtLRRLLQERELVEPLtPsGEA
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04899 S144 PSP GNAI2 GNAI2B LSGVIRRLWADHGVQACFGRsREYQLNDSAAYYLNDLERIA
P04899 S302 PSP GNAI2 GNAI2B sPLTICFPEYTGANKYDEAAsYIQSKFEDLNKRKDTKEIYt
P04899 S44 PSP GNAI2 GNAI2B REDGEKAAREVKLLLLGAGEsGKstIVKQMKIIHEDGySEE
P05091 S296 SIGNOR|PSP ALDH2 ALDM SSNLKRVtLELGGKSPNIIMsDADMDWAVEQAHFALFFNQG
P05091 T202 SIGNOR|PSP ALDH2 ALDM IIPWNFPLLMQAWKLGPALAtGNVVVMKVAEQTPLTALYVA
P05091 T429 SIGNOR|PSP ALDH2 ALDM GMTIAKEEIFGPVMQILKFKtIEEVVGRANNSTYGLAAAVF
P05556 T788 PSP ITGB1 FNRB MDF2 MSK12 KEKMNAKWDtGENPIyKsAVttVVNPKyEGK__________
P05556 T789 PSP ITGB1 FNRB MDF2 MSK12 EKMNAKWDtGENPIyKsAVttVVNPKyEGK___________
P05783 S53 GPS6|SIGNOR|ELM|iPTMNet|PSP KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S24 GPS6 KRT8 CYK8 RVtQKsYKVSTSGPRAFSSRsYTSGPGSRIsSSSFSRVGSS
P05787 S9 GPS6 KRT8 CYK8 ____________MSIRVtQKsYKVSTSGPRAFSSRsYTSGP
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P08581 S985 GPS6|ELM|PSP MET GsELVRYDARVHtPHLDRLVsARsVsPttEMVsNEsVDyRA
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09211 S185 SIGNOR GSTP1 FAEES3 GST3 VLAPGCLDAFPLLSAYVGRLsARPKLKAFLASPEyVNLPIN
P09211 S43 SIGNOR GSTP1 FAEES3 GST3 ADQGQSWKEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtL
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11362 S779 SIGNOR|PSP FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR ALTSNQEyLDLSMPLDQysPsFPDTRsstCsSGEDsVFSHE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14618 Y105 PSP PKM OIP3 PK2 PK3 PKM2 AEtIKNVRtAtEsFAsDPILyRPVAVALDTKGPEIRtGLIK
P15336 T52 SIGNOR|PSP ATF2 CREB2 CREBP1 CGQRFTNEDHLAVHKHKHEMtLKFGPARNDsVIVADQtPtP
P16220 S119 PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P17302 S365 SIGNOR GJA1 GJAL KKLAAGHELQPLAIVDQRPssRAssRAssRPRPDDLEI___
P17302 S368 GPS6|SIGNOR|ELM|PSP GJA1 GJAL AAGHELQPLAIVDQRPssRAssRAssRPRPDDLEI______
P17302 S369 SIGNOR GJA1 GJAL AGHELQPLAIVDQRPssRAssRAssRPRPDDLEI_______
P17302 S373 SIGNOR GJA1 GJAL LQPLAIVDQRPssRAssRAssRPRPDDLEI___________
P18507 S366 GPS6|SIGNOR|ELM GABRG2 VFSALVEYGTLHYFVSNRKPsKDKDKKKKNPLLRMFSFKAP
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19429 S44 GPS6|ELM|PSP TNNI3 TNNC1 sNyRAYAtEPHAKKKsKIsAsRKLQLKtLLLQIAKQELERE
P20339 T7 PSP RAB5A RAB5 ______________MAsRGAtRPNGPNTGNKICQFKLVLLG
P21802 S782 SIGNOR FGFR2 BEK KGFR KSAM TLTTNEEyLDLSQPLEQYsPsYPDTRSSCSSGDDSVFSPDP
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23975 S259 PSP SLC6A2 NAT1 NET1 SLC6A5 LCLMVVVIVLYFSLWKGVKtsGKVVWITATLPYFVLFVLLV
P24723 T207 Sugiyama PRKCH PKCL PRKCL HCREFIWGVFGKQGYQCQVCtCVVHKRCHHLIVTACTCQNN
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P28329 S464 SIGNOR CHAT PFDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLR
P28329 S465 SIGNOR CHAT FDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLRW
P28329 S558 SIGNOR CHAT ALQLAFYRLHRRLVPTYESAsIRRFQEGRVDNIRSAtPEAL
P28329 S594 SIGNOR CHAT tPEALAFVRAVTDHKAAVPAsEKLLLLKDAIRAQTAYTVMA
P29353 S139 SIGNOR SHC1 SHC SHCA GRRTRVEGGQLGGEEWTRHGsFVNKPTRGWLHPNDKVMGPG
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P35236 S246 SIGNOR PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40763 S727 GPS6|SIGNOR|PSP STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P41143 S344 SIGNOR|iPTMNet OPRD1 OPRD NFKRCFRQLCRKPCGRPDPSsFSRAREATARERVtACtPsD
P41594 S840 SIGNOR|iPTMNet GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43629 S415 SIGNOR|PSP KIR3DL1 CD158E NKAT3 NKB1 EVTYAQLDHCVFTQRKITRPsQRPKtPPTDTILYTELPNAK
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46940 S1443 GPS6|SIGNOR|ELM|PSP IQGAP1 KIAA0051 AMQRRAIRDAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGL
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48751 S67 GPS6|SIGNOR|ELM|iPTMNet SLC4A3 AE3 FGDLISKPPAWDPEKPSRSYsERDFEFHRHTSHHTHHPLSA
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P59047 S331 SIGNOR NLRP5 MATER NALP5 GMFSYVFFLPVREMQRKKESsVTEFISREWPDSQAPVTEIM
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62491 S177 SIGNOR|PSP RAB11A RAB11 DSTNVEAAFQTILTEIYRIVsQKQMSDRRENDMsPsNNVVP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P78536 T735 PSP ADAM17 CSVP TACE MLSSMDSASVRIIKPFPAPQtPGRLQPAPVIPSAPAAPKLD
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
P98170 S87 PSP XIAP API3 BIRC4 IAP3 HAAVDRWQYGDSAVGRHRKVsPNCRFINGFYLENSATQSTN
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02156 S234 PSP|Sugiyama PRKCE PKCE ELIITKCAGLKKQEtPDQVGsQRFsVNMPHKFGIHNYKVPT
Q02156 S238 Sugiyama PRKCE PKCE TKCAGLKKQEtPDQVGsQRFsVNMPHKFGIHNYKVPTFCDH
Q02156 S316 PSP|Sugiyama PRKCE PKCE ARGIAKVLADLGVtPDKItNsGQRRKKLIAGAEsPQPAsGs
Q02156 S329 Sugiyama PRKCE PKCE tPDKItNsGQRRKKLIAGAEsPQPAsGssPsEEDRsKsAPt
Q02156 S337 Sugiyama PRKCE PKCE GQRRKKLIAGAEsPQPAsGssPsEEDRsKsAPtsPCDQEIK
Q02156 S339 Sugiyama PRKCE PKCE RRKKLIAGAEsPQPAsGssPsEEDRsKsAPtsPCDQEIKEL
Q02156 S346 Sugiyama PRKCE PKCE GAEsPQPAsGssPsEEDRsKsAPtsPCDQEIKELENNIRKA
Q02156 S368 PSP|Sugiyama PRKCE PKCE PtsPCDQEIKELENNIRKALsFDNRGEEHRAAssPDGQLMs
Q02156 S381 Sugiyama PRKCE PKCE NNIRKALsFDNRGEEHRAAssPDGQLMsPGENGEVRQGQAK
Q02156 S388 Sugiyama PRKCE PKCE sFDNRGEEHRAAssPDGQLMsPGENGEVRQGQAKRLGLDEF
Q02156 S62 Sugiyama PRKCE PKCE IALNVDDSRIGQTATKQKTNsPAWHDEFVTDVCNGRKIELA
Q02156 S655 Sugiyama PRKCE PKCE VSILKAFMTKNPHKRLGCVAsQNGEDAIKQHPFFKEIDWVL
Q02156 S729 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKCE PKCE LtLVDEAIVKQINQEEFKGFsYFGEDLMP____________
Q02156 T205 Sugiyama PRKCE PKCE HCRDFIWGVIGKQGYQCQVCtCVVHKRCHELIITKCAGLKK
Q02156 T228 Sugiyama PRKCE PKCE VHKRCHELIITKCAGLKKQEtPDQVGsQRFsVNMPHKFGIH
Q02156 T309 Sugiyama PRKCE PKCE APNCGVDARGIAKVLADLGVtPDKItNsGQRRKKLIAGAEs
Q02156 T314 Sugiyama PRKCE PKCE VDARGIAKVLADLGVtPDKItNsGQRRKKLIAGAEsPQPAs
Q02156 T703 iPTMNet PRKCE PKCE PPFKPRIKTKRDVNNFDQDFtREEPVLtLVDEAIVKQINQE
Q02156 T710 Sugiyama PRKCE PKCE KTKRDVNNFDQDFtREEPVLtLVDEAIVKQINQEEFKGFsY
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q14145 S599 PSP KEAP1 INRF2 KIAA0132 KLHL19 DSVECYDPDTDTWSEVTRMTsGRsGVGVAVTMEPCRKQIDQ
Q14145 S602 PSP KEAP1 INRF2 KIAA0132 KLHL19 ECYDPDTDTWSEVTRMTsGRsGVGVAVTMEPCRKQIDQQNC
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15139 S738 GPS6|PSP PRKD1 PKD PKD1 PRKCM DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNK
Q15139 S742 GPS6|PSP PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q16612 S59 SIGNOR|PSP NREP C5orf13 P311 KKNDETNAASLTPLGSSELRsPRISYLHFF___________
Q16625 T403 PSP OCLN AKGRAGRSKRTEQDHyEtDyttGGEsCDELEEDWIREYPPI
Q16625 T404 SIGNOR|PSP OCLN KGRAGRSKRTEQDHyEtDyttGGEsCDELEEDWIREYPPIt
Q16625 T424 SIGNOR OCLN tGGEsCDELEEDWIREYPPItSDQQRQLYKRNFDtGLQEyK
Q16625 T438 SIGNOR OCLN REYPPItSDQQRQLYKRNFDtGLQEyKsLQSELDEINKELS
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5JXC2 S303 SIGNOR|PSP MIIP IIP45 VSIPLSILEPPHRYHIHRRKsFDAsDTLALPRHCLLGWDIF
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86XR7 S16 GPS6|SIGNOR|PSP TICAM2 TIRAP3 TIRP TRAM _____MGIGKSKINSCPLSLsWGKRHsVDtsPGYHESDSKK
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8NAF0 S455 Sugiyama ZNF579 AGGPAPHPCPRCPRRFSRAYsLLRHQRCHRAELERAAALQA
Q8NE86 S92 PSP MCU C10orf42 CCDC109A SDDVTVVYQNGLPVISVRLPsRRERCQFTLKPISDSVGVFL
Q8NER1 S502 SIGNOR|iPTMNet TRPV1 VR1 VLGGVYFFFRGIQYFLQRRPsMKTLFVDSYSEMLFFLQSLF
Q8NER1 S775 SIGNOR|iPTMNet TRPV1 VR1 TNVGIINEDPGNCEGVKRTLsFSLRSSRVSGRHWKNFALVP
Q8NER1 S801 SIGNOR|iPTMNet|PSP TRPV1 VR1 SRVSGRHWKNFALVPLLREAsARDRQSAQPEEVYLRQFSGs
Q8NER1 S821 SIGNOR|iPTMNet TRPV1 VR1 sARDRQSAQPEEVYLRQFSGsLKPEDAEVFKSPAASGEK__
Q8NER1 T145 SIGNOR|iPTMNet TRPV1 VR1 NNCQDLESLLLFLQKSKKHLtDNEFKDPETGKTCLLKAMLN
Q8NER1 T705 SIGNOR|iPTMNet TRPV1 VR1 ETVNKIAQESKNIWKLQRAItILDTEKSFLKCMRKAFRSGK
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q92934 S118 SIGNOR|PSP BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR|PSP BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q96A00 T38 GPS6|SIGNOR|ELM|iPTMNet|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96GD4 S227 PSP AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 LLGLKGELKIADFGWSVHAPsLRRKtMCGtLDYLPPEMIEG
Q99259 T91 SIGNOR|iPTMNet GAD1 GAD GAD67 QSSKNLLSCENSDRDARFRRtETDFSNLFARDLLPAKNGEE
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BR76 S2 PSP CORO1B ___________________MsFRKVVRQSKFRHVFGQPVKN
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6 S706 SIGNOR|PSP PRKD2 PKD2 HSPC187 DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQ
Q9BZL6 S710 SIGNOR|PSP PRKD2 PKD2 HSPC187 QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNR
Q9BZL6 S876 SIGNOR|PSP PRKD2 PKD2 HSPC187 DLGGACPPQDHDMQGLAERIsVL__________________
Q9H9S0 S135 PSP NANOG QRQKYLSLQQMQELSNILNLsYKQVKTWFQNQRMKSKRWQK
Q9H9S0 S79 PSP NANOG DLLIQDsPDsSTsPKGKQPtsAEKSVAKKEDKVPVKKQKTR
Q9H9S0 T200 PSP NANOG SYHQGCLVNPTGNLPMWSNQtWNNSTWSNQTQNIQSWSNHS
Q9H9S0 T280 PSP NANOG ASDLEAALEAAGEGLNVIQQtTRYFSTPQTMDLFLNYSMNM
Q9H9S0 T78 PSP NANOG MDLLIQDsPDsSTsPKGKQPtsAEKSVAKKEDKVPVKKQKT
Q9HAW7 S432 PSP UGT1A7 GNT1 UGT1 VLEMTSEDLENALKAVINDKsYKENIMRLSSLHKDRPVEPL
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UBS0 S473 GPS6|SIGNOR|ELM|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9Y3C1 S16 Sugiyama NOP16 CGI-117 HSPC111 _____MPKAKGKTRRQKFGYsVNRKRLNRNARRKAAPRIEC
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Signal Transduction R-HSA-162582 2.886580e-15 14.540 1 0
Cell Cycle, Mitotic R-HSA-69278 3.774758e-15 14.423 0 0
Cellular Senescence R-HSA-2559583 1.507239e-12 11.822 0 0
Cell Cycle Checkpoints R-HSA-69620 1.266198e-11 10.897 0 0
M Phase R-HSA-68886 1.097018e-10 9.960 0 0
Axon guidance R-HSA-422475 1.048548e-10 9.979 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.513868e-10 9.345 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.042600e-09 8.517 0 0
Nervous system development R-HSA-9675108 6.209917e-09 8.207 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.124675e-09 8.147 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.914271e-09 8.102 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.810244e-08 7.742 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.005274e-08 7.698 0 0
Diseases of programmed cell death R-HSA-9645723 2.238126e-08 7.650 0 0
Apoptotic execution phase R-HSA-75153 3.101908e-08 7.508 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.421350e-08 7.466 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.206576e-08 7.283 0 0
Chromatin modifying enzymes R-HSA-3247509 5.082948e-08 7.294 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.533513e-08 7.257 0 0
Mitotic Prophase R-HSA-68875 6.535853e-08 7.185 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.357497e-08 7.133 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.812684e-08 7.107 0 0
HATs acetylate histones R-HSA-3214847 8.039772e-08 7.095 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.101327e-07 6.958 0 0
Chromatin organization R-HSA-4839726 1.141827e-07 6.942 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.521857e-07 6.818 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.449829e-07 6.839 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.509313e-07 6.821 0 0
DNA methylation R-HSA-5334118 1.552654e-07 6.809 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.979579e-07 6.703 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.218574e-07 6.654 0 0
Packaging Of Telomere Ends R-HSA-171306 2.595985e-07 6.586 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.595985e-07 6.586 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.095257e-07 6.509 0 0
Meiotic synapsis R-HSA-1221632 3.509852e-07 6.455 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.769021e-07 6.424 0 0
HDACs deacetylate histones R-HSA-3214815 6.535593e-07 6.185 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.020784e-07 6.154 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.983515e-07 6.047 0 0
Nucleosome assembly R-HSA-774815 8.983515e-07 6.047 0 0
NRAGE signals death through JNK R-HSA-193648 8.823914e-07 6.054 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.005634e-06 5.998 0 0
Meiosis R-HSA-1500620 1.269312e-06 5.896 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.319247e-06 5.880 0 0
Defective pyroptosis R-HSA-9710421 1.528303e-06 5.816 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.678496e-06 5.775 0 0
Meiotic recombination R-HSA-912446 1.869356e-06 5.728 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.865055e-06 5.729 0 0
Mitotic Anaphase R-HSA-68882 1.901356e-06 5.721 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.175310e-06 5.662 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.178817e-06 5.662 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.359485e-06 5.474 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.581278e-06 5.446 0 0
Cellular responses to stress R-HSA-2262752 3.839468e-06 5.416 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.102933e-06 5.387 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.102933e-06 5.387 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.361034e-06 5.271 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.412259e-06 5.267 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.124350e-06 5.213 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.901786e-06 5.229 0 0
DNA Double Strand Break Response R-HSA-5693606 5.997588e-06 5.222 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.712011e-06 5.173 0 0
Mitotic Prometaphase R-HSA-68877 7.460477e-06 5.127 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.477546e-06 5.126 0 0
G2/M Checkpoints R-HSA-69481 8.725668e-06 5.059 0 0
Cellular responses to stimuli R-HSA-8953897 9.848726e-06 5.007 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.079355e-05 4.967 0 0
G alpha (12/13) signalling events R-HSA-416482 1.134012e-05 4.945 0 0
Separation of Sister Chromatids R-HSA-2467813 1.272955e-05 4.895 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.305919e-05 4.884 0 0
Post NMDA receptor activation events R-HSA-438064 1.543663e-05 4.811 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.815992e-05 4.741 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.764196e-05 4.753 0 0
Cleavage of the damaged purine R-HSA-110331 1.775150e-05 4.751 0 0
Deubiquitination R-HSA-5688426 2.008749e-05 4.697 0 0
mRNA 3'-end processing R-HSA-72187 2.147287e-05 4.668 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.147287e-05 4.668 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.184168e-05 4.661 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.405597e-05 4.619 0 0
Depurination R-HSA-73927 2.422480e-05 4.616 0 0
Regulation of TP53 Activity R-HSA-5633007 2.820836e-05 4.550 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.445719e-05 4.463 0 0
Depyrimidination R-HSA-73928 3.445719e-05 4.463 0 0
Reproduction R-HSA-1474165 3.492108e-05 4.457 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.514022e-05 4.454 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.710893e-05 4.431 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.945695e-05 4.404 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.170541e-05 4.286 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.597462e-05 4.252 0 0
Kinesins R-HSA-983189 5.597462e-05 4.252 0 0
Chromosome Maintenance R-HSA-73886 5.649126e-05 4.248 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.670678e-05 4.246 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.939636e-05 4.226 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.283146e-05 4.202 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.783267e-05 4.169 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.883623e-05 4.162 0 0
Apoptosis R-HSA-109581 7.121712e-05 4.147 0 0
Homology Directed Repair R-HSA-5693538 7.352027e-05 4.134 0 0
L1CAM interactions R-HSA-373760 1.114255e-04 3.953 0 0
Recycling pathway of L1 R-HSA-437239 1.275607e-04 3.894 0 0
Cell-Cell communication R-HSA-1500931 1.347245e-04 3.871 0 0
Metalloprotease DUBs R-HSA-5689901 1.360061e-04 3.866 0 0
ESR-mediated signaling R-HSA-8939211 1.405783e-04 3.852 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.474255e-04 3.831 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.508324e-04 3.822 0 0
Signaling by Hippo R-HSA-2028269 1.600881e-04 3.796 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.703881e-04 3.769 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.703881e-04 3.769 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.755313e-04 3.756 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.883379e-04 3.725 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.887293e-04 3.724 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.907918e-04 3.719 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.966908e-04 3.706 1 0
mRNA Splicing R-HSA-72172 1.991556e-04 3.701 0 0
Selective autophagy R-HSA-9663891 2.228780e-04 3.652 0 0
Programmed Cell Death R-HSA-5357801 2.217372e-04 3.654 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.490898e-04 3.604 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.529057e-04 3.597 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.873099e-04 3.542 0 0
Telomere Maintenance R-HSA-157579 2.940316e-04 3.532 0 0
Ub-specific processing proteases R-HSA-5689880 3.070676e-04 3.513 0 0
Death Receptor Signaling R-HSA-73887 3.168662e-04 3.499 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.232905e-04 3.490 0 0
Cell junction organization R-HSA-446728 3.395847e-04 3.469 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.449689e-04 3.462 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.557942e-04 3.449 0 0
RNA Polymerase I Transcription R-HSA-73864 3.557942e-04 3.449 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.647337e-04 3.438 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.653090e-04 3.437 0 0
HCMV Early Events R-HSA-9609690 3.989548e-04 3.399 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.127751e-04 3.384 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.578973e-04 3.339 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.966663e-04 3.304 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.127436e-04 3.290 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.009556e-04 3.300 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.141782e-04 3.289 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.317102e-04 3.274 0 0
Gene expression (Transcription) R-HSA-74160 5.677425e-04 3.246 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.787759e-04 3.237 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.830696e-04 3.234 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.005908e-04 3.221 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.029094e-04 3.220 0 0
RNA Polymerase II Transcription R-HSA-73857 6.683443e-04 3.175 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.814716e-04 3.167 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.487267e-04 3.126 0 0
Gene Silencing by RNA R-HSA-211000 7.300822e-04 3.137 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.551904e-04 3.122 0 0
Neurodegenerative Diseases R-HSA-8863678 7.551904e-04 3.122 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.635435e-04 3.117 0 0
Developmental Biology R-HSA-1266738 7.697650e-04 3.114 0 0
Oncogene Induced Senescence R-HSA-2559585 7.826815e-04 3.106 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.858259e-04 3.105 0 0
DNA Repair R-HSA-73894 8.062003e-04 3.094 0 0
Signaling by ROBO receptors R-HSA-376176 8.084511e-04 3.092 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.609770e-04 3.065 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.979323e-04 3.047 0 0
Aggrephagy R-HSA-9646399 9.546983e-04 3.020 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.554992e-04 3.020 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.019170e-03 2.992 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.066879e-03 2.972 0 0
Metabolism of RNA R-HSA-8953854 1.117428e-03 2.952 0 0
G2/M Transition R-HSA-69275 1.210221e-03 2.917 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.221490e-03 2.913 0 0
Signaling by NOTCH R-HSA-157118 1.373659e-03 2.862 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.573107e-03 2.803 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.573107e-03 2.803 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.573107e-03 2.803 0 0
FOXO-mediated transcription R-HSA-9614085 1.579083e-03 2.802 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.769854e-03 2.752 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.813294e-03 2.742 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.811251e-03 2.742 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.811251e-03 2.742 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.946920e-03 2.711 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.950518e-03 2.710 0 0
Adherens junctions interactions R-HSA-418990 2.133375e-03 2.671 0 0
Cell-cell junction organization R-HSA-421270 2.167202e-03 2.664 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.274419e-03 2.643 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.411134e-03 2.618 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.480143e-03 2.606 0 0
Neuronal System R-HSA-112316 2.570317e-03 2.590 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.579070e-03 2.589 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.601358e-03 2.585 0 0
Base Excision Repair R-HSA-73884 2.615215e-03 2.582 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.739011e-03 2.562 0 0
Signaling by VEGF R-HSA-194138 2.815168e-03 2.550 0 0
Polo-like kinase mediated events R-HSA-156711 2.861760e-03 2.543 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.861760e-03 2.543 0 0
Semaphorin interactions R-HSA-373755 3.004413e-03 2.522 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.019166e-03 2.520 0 0
TRP channels R-HSA-3295583 3.784561e-03 2.422 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.827727e-03 2.417 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.827727e-03 2.417 0 0
Rap1 signalling R-HSA-392517 3.843343e-03 2.415 0 0
EPH-Ephrin signaling R-HSA-2682334 3.865891e-03 2.413 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.094710e-03 2.388 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.704281e-03 2.328 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.704281e-03 2.328 0 0
MAPK family signaling cascades R-HSA-5683057 4.895161e-03 2.310 0 0
Interleukin-12 signaling R-HSA-9020591 4.929046e-03 2.307 0 0
Amyloid fiber formation R-HSA-977225 4.970740e-03 2.304 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.352629e-03 2.271 0 0
Macroautophagy R-HSA-1632852 6.055516e-03 2.218 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.770004e-03 2.169 0 0
Integrin signaling R-HSA-354192 6.881326e-03 2.162 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.881326e-03 2.162 0 0
RET signaling R-HSA-8853659 6.293764e-03 2.201 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.357787e-03 2.197 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.564503e-03 2.183 0 0
Netrin-1 signaling R-HSA-373752 6.171946e-03 2.210 0 0
RMTs methylate histone arginines R-HSA-3214858 6.171946e-03 2.210 0 0
Generic Transcription Pathway R-HSA-212436 6.441382e-03 2.191 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.770004e-03 2.169 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.555397e-03 2.122 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.599477e-03 2.119 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.104009e-03 2.091 0 0
Signaling by WNT R-HSA-195721 8.277905e-03 2.082 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.375886e-03 2.077 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.393411e-03 2.076 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.437507e-03 2.074 0 0
Signaling by ALK in cancer R-HSA-9700206 8.437507e-03 2.074 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.444680e-03 2.073 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.628534e-03 2.064 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.628534e-03 2.064 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.628534e-03 2.064 0 0
Signaling by RAS mutants R-HSA-6802949 8.628534e-03 2.064 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.114976e-03 2.040 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.210597e-03 2.036 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.367423e-03 2.028 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.674521e-03 2.014 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.954745e-03 2.002 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.070900e-02 1.970 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.008890e-02 1.996 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.149494e-02 1.939 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.117168e-02 1.952 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.085095e-02 1.965 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.063770e-02 1.973 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.149494e-02 1.939 0 0
HCMV Infection R-HSA-9609646 1.034597e-02 1.985 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.045022e-02 1.981 0 0
DNA Replication R-HSA-69306 1.185932e-02 1.926 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.207619e-02 1.918 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.242339e-02 1.906 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.245325e-02 1.905 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.249114e-02 1.903 0 0
Signaling by Interleukins R-HSA-449147 1.253988e-02 1.902 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.283952e-02 1.891 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.309860e-02 1.883 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.319346e-02 1.880 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.319346e-02 1.880 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.319346e-02 1.880 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.319346e-02 1.880 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.331577e-02 1.876 0 0
Gap junction trafficking R-HSA-190828 1.335826e-02 1.874 0 0
Gap junction trafficking and regulation R-HSA-157858 1.370957e-02 1.863 0 0
Translation initiation complex formation R-HSA-72649 1.392110e-02 1.856 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.426684e-02 1.846 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.442555e-02 1.841 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.482066e-02 1.829 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.482066e-02 1.829 0 0
Pyroptosis R-HSA-5620971 1.493957e-02 1.826 0 0
FLT3 Signaling R-HSA-9607240 1.509923e-02 1.821 0 0
Autophagy R-HSA-9612973 1.512739e-02 1.820 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.515550e-02 1.819 0 0
Membrane Trafficking R-HSA-199991 1.522698e-02 1.817 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.553642e-02 1.809 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.616196e-02 1.792 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.616196e-02 1.792 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.644484e-02 1.784 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.991376e-02 1.701 0 0
MAP2K and MAPK activation R-HSA-5674135 1.765230e-02 1.753 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.765230e-02 1.753 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.938006e-02 1.713 0 0
Specification of primordial germ cells R-HSA-9827857 1.913229e-02 1.718 0 0
HDMs demethylate histones R-HSA-3214842 2.004003e-02 1.698 0 0
Long-term potentiation R-HSA-9620244 2.004003e-02 1.698 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.059182e-02 1.686 1 0
Interleukin-12 family signaling R-HSA-447115 2.062977e-02 1.686 0 0
Interleukin-37 signaling R-HSA-9008059 2.160239e-02 1.665 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.178732e-02 1.662 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.178732e-02 1.662 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.178732e-02 1.662 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.208997e-02 1.656 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.211859e-02 1.655 0 0
Gap junction assembly R-HSA-190861 2.267391e-02 1.644 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.276944e-02 1.643 0 0
Peptide chain elongation R-HSA-156902 2.285393e-02 1.641 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.335486e-02 1.632 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.335486e-02 1.632 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.358071e-02 1.627 0 0
TBC/RABGAPs R-HSA-8854214 2.372691e-02 1.625 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.407074e-02 1.619 0 0
Apoptotic factor-mediated response R-HSA-111471 2.407074e-02 1.619 0 0
Transmission across Chemical Synapses R-HSA-112315 2.473803e-02 1.607 0 0
Trafficking of AMPA receptors R-HSA-399719 2.565110e-02 1.591 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.574794e-02 1.589 0 0
Adrenoceptors R-HSA-390696 2.595442e-02 1.586 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.611909e-02 1.583 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.667146e-02 1.574 0 0
Activation of RAC1 R-HSA-428540 2.667146e-02 1.574 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.698169e-02 1.569 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.702476e-02 1.568 0 0
Opioid Signalling R-HSA-111885 2.723955e-02 1.565 0 0
MHC class II antigen presentation R-HSA-2132295 2.727563e-02 1.564 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.315370e-02 1.479 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.315370e-02 1.479 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.315370e-02 1.479 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.479682e-02 1.458 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.983943e-02 1.525 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.022244e-02 1.520 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.534725e-02 1.452 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.442875e-02 1.463 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.064587e-02 1.514 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.008728e-02 1.522 0 0
Signaling by EGFR R-HSA-177929 3.442875e-02 1.463 0 0
G0 and Early G1 R-HSA-1538133 3.022244e-02 1.520 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.123638e-02 1.505 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.534725e-02 1.452 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.055799e-02 1.515 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.315370e-02 1.479 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.534725e-02 1.452 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.079441e-02 1.512 1 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.303715e-02 1.481 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.184195e-02 1.497 0 0
Signaling by NTRKs R-HSA-166520 2.950445e-02 1.530 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.442875e-02 1.463 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.536522e-02 1.451 0 0
Signaling by TGFBR3 R-HSA-9839373 3.558045e-02 1.449 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.562759e-02 1.448 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.580146e-02 1.446 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.650583e-02 1.438 0 0
G-protein mediated events R-HSA-112040 3.651335e-02 1.438 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.655613e-02 1.437 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.655613e-02 1.437 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.655613e-02 1.437 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.655613e-02 1.437 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.655613e-02 1.437 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.655613e-02 1.437 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.655613e-02 1.437 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.761539e-02 1.425 0 0
Neurexins and neuroligins R-HSA-6794361 3.956948e-02 1.403 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.052710e-02 1.392 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.064587e-02 1.391 0 0
MTOR signalling R-HSA-165159 4.090586e-02 1.388 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.117894e-02 1.385 0 0
Stimuli-sensing channels R-HSA-2672351 4.168152e-02 1.380 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.191486e-02 1.378 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.225741e-02 1.374 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.436543e-02 1.353 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.436543e-02 1.353 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.535107e-02 1.343 0 0
PKR-mediated signaling R-HSA-9833482 4.574399e-02 1.340 0 0
TGFBR3 expression R-HSA-9839394 4.612218e-02 1.336 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.709579e-02 1.327 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.711500e-02 1.327 0 0
Activation of BH3-only proteins R-HSA-114452 4.711500e-02 1.327 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.725869e-02 1.326 0 0
RAF activation R-HSA-5673000 4.736780e-02 1.325 0 0
Signal amplification R-HSA-392518 4.736780e-02 1.325 0 0
Nuclear import of Rev protein R-HSA-180746 4.736780e-02 1.325 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.736780e-02 1.325 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.772060e-02 1.321 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.786623e-02 1.320 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.958692e-02 1.305 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.119047e-02 1.291 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.200057e-02 1.208 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.200057e-02 1.208 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.200057e-02 1.208 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.454020e-02 1.190 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.454020e-02 1.190 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.454020e-02 1.190 0 0
Regulation of KIT signaling R-HSA-1433559 5.542853e-02 1.256 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.263321e-02 1.279 0 0
Notch-HLH transcription pathway R-HSA-350054 6.218579e-02 1.206 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.295159e-02 1.201 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.456382e-02 1.263 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.456382e-02 1.263 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.062309e-02 1.217 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.691139e-02 1.245 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.272182e-02 1.203 0 0
Ephrin signaling R-HSA-3928664 5.994928e-02 1.222 0 0
mTORC1-mediated signalling R-HSA-166208 6.218579e-02 1.206 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.350950e-02 1.272 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.350950e-02 1.272 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.350950e-02 1.272 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.350950e-02 1.272 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.249600e-02 1.280 0 0
Signaling by NOTCH1 R-HSA-1980143 5.235460e-02 1.281 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.616486e-02 1.251 0 0
Eukaryotic Translation Termination R-HSA-72764 5.201560e-02 1.284 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.263321e-02 1.279 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.454020e-02 1.190 0 0
Regulation of PTEN localization R-HSA-8948747 6.454020e-02 1.190 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.994928e-02 1.222 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.357158e-02 1.271 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.350950e-02 1.272 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.535204e-02 1.257 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.929025e-02 1.227 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.519281e-02 1.186 0 0
Heme signaling R-HSA-9707616 6.538387e-02 1.185 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.614801e-02 1.179 0 0
DCC mediated attractive signaling R-HSA-418885 6.801234e-02 1.167 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.801234e-02 1.167 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.801234e-02 1.167 0 0
Sensory processing of sound R-HSA-9659379 6.840218e-02 1.165 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.876020e-02 1.163 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.015569e-02 1.154 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.098207e-02 1.149 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.168759e-02 1.145 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.168759e-02 1.145 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.168759e-02 1.145 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.212107e-02 1.142 0 0
Influenza Infection R-HSA-168255 7.427206e-02 1.129 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.470658e-02 1.127 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.470658e-02 1.127 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 7.470658e-02 1.127 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.651929e-02 1.116 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.651929e-02 1.116 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.651929e-02 1.116 0 0
HCMV Late Events R-HSA-9610379 7.702747e-02 1.113 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.888405e-02 1.103 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.908206e-02 1.102 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.059146e-02 1.094 0 0
Striated Muscle Contraction R-HSA-390522 8.138801e-02 1.089 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.138801e-02 1.089 0 0
Cellular response to heat stress R-HSA-3371556 8.181056e-02 1.087 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.211821e-02 1.086 0 0
Selenocysteine synthesis R-HSA-2408557 8.238844e-02 1.084 0 0
snRNP Assembly R-HSA-191859 8.271462e-02 1.082 0 0
Metabolism of non-coding RNA R-HSA-194441 8.271462e-02 1.082 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.323882e-02 1.080 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.423958e-02 1.074 0 0
Deadenylation of mRNA R-HSA-429947 8.434582e-02 1.074 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.447207e-02 1.073 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.447207e-02 1.073 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.447207e-02 1.073 0 0
UCH proteinases R-HSA-5689603 8.500961e-02 1.071 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 8.855969e-02 1.053 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 8.855969e-02 1.053 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.855969e-02 1.053 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.855969e-02 1.053 0 0
G2 Phase R-HSA-68911 8.855969e-02 1.053 0 0
NrCAM interactions R-HSA-447038 8.855969e-02 1.053 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.946406e-02 1.048 0 0
S Phase R-HSA-69242 9.046205e-02 1.044 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.207860e-01 0.918 0 0
Regulation of TP53 Expression R-HSA-6804754 1.207860e-01 0.918 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.207860e-01 0.918 0 0
Diseases of cellular response to stress R-HSA-9675132 1.207860e-01 0.918 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.207860e-01 0.918 0 0
Potassium transport channels R-HSA-1296067 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.207860e-01 0.918 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.207860e-01 0.918 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.207860e-01 0.918 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.190238e-01 0.924 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.190238e-01 0.924 0 0
Signaling by MAPK mutants R-HSA-9652817 1.190238e-01 0.924 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.190238e-01 0.924 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.070314e-01 0.970 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.070314e-01 0.970 0 0
Gap junction degradation R-HSA-190873 1.070314e-01 0.970 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.070314e-01 0.970 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.410042e-02 1.026 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.410042e-02 1.026 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.410042e-02 1.026 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.410042e-02 1.026 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.410042e-02 1.026 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.135506e-01 0.945 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.772353e-02 1.010 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.147834e-01 0.940 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.469720e-02 1.024 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.030878e-01 0.987 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.068656e-02 1.042 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.068656e-02 1.042 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.173844e-01 0.930 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.173844e-01 0.930 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.052721e-01 0.978 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.202761e-01 0.920 0 0
Viral mRNA Translation R-HSA-192823 9.471059e-02 1.024 0 0
Mitophagy R-HSA-5205647 9.185517e-02 1.037 0 0
Signalling to ERKs R-HSA-187687 1.030878e-01 0.987 0 0
Myogenesis R-HSA-525793 1.105776e-01 0.956 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.070314e-01 0.970 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.190238e-01 0.924 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.099378e-01 0.959 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.070314e-01 0.970 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 9.410042e-02 1.026 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.135506e-01 0.945 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.068077e-02 1.042 0 0
Calmodulin induced events R-HSA-111933 1.150789e-01 0.939 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.325990e-02 1.030 0 0
Calcineurin activates NFAT R-HSA-2025928 1.070314e-01 0.970 0 0
CaM pathway R-HSA-111997 1.150789e-01 0.939 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.772353e-02 1.010 0 0
Cardiac conduction R-HSA-5576891 1.182181e-01 0.927 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.173844e-01 0.930 0 0
Co-inhibition by PD-1 R-HSA-389948 1.163790e-01 0.934 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.365797e-02 1.028 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.111385e-01 0.954 0 0
Muscle contraction R-HSA-397014 9.141463e-02 1.039 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.469720e-02 1.024 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.163790e-01 0.934 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.133787e-01 0.945 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.897357e-02 1.004 0 0
Maturation of nucleoprotein R-HSA-9683610 1.135506e-01 0.945 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.125534e-01 0.949 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.215731e-01 0.915 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.218897e-01 0.914 0 0
Centrosome maturation R-HSA-380287 1.226956e-01 0.911 0 0
Protein ubiquitination R-HSA-8852135 1.226956e-01 0.911 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.251816e-01 0.902 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.251816e-01 0.902 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.251816e-01 0.902 0 0
Potassium Channels R-HSA-1296071 1.288953e-01 0.890 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.296962e-01 0.887 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.305083e-01 0.884 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.316889e-01 0.880 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.319904e-01 0.879 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.319904e-01 0.879 0 0
Regulation of CDH11 function R-HSA-9762292 1.319904e-01 0.879 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.319904e-01 0.879 0 0
Signaling by Leptin R-HSA-2586552 1.319904e-01 0.879 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.338679e-01 0.873 0 0
Ca-dependent events R-HSA-111996 1.338679e-01 0.873 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.342388e-01 0.872 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.352288e-01 0.869 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.385235e-01 0.858 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.385768e-01 0.858 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.385768e-01 0.858 0 0
KIT mutants bind TKIs R-HSA-9669921 1.385768e-01 0.858 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.385768e-01 0.858 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.385768e-01 0.858 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.385768e-01 0.858 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.385768e-01 0.858 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.385768e-01 0.858 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.385768e-01 0.858 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.385768e-01 0.858 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.385768e-01 0.858 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.385768e-01 0.858 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.385768e-01 0.858 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.385768e-01 0.858 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.385768e-01 0.858 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.385768e-01 0.858 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.385768e-01 0.858 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.385768e-01 0.858 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.385768e-01 0.858 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.385768e-01 0.858 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.385768e-01 0.858 0 0
GPER1 signaling R-HSA-9634597 1.387150e-01 0.858 0 0
Co-stimulation by CD28 R-HSA-389356 1.387150e-01 0.858 0 0
Intraflagellar transport R-HSA-5620924 1.387150e-01 0.858 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.718661e-01 0.765 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.718661e-01 0.765 0 0
Axonal growth stimulation R-HSA-209563 1.718661e-01 0.765 0 0
MET activates PTPN11 R-HSA-8865999 1.718661e-01 0.765 0 0
CREB phosphorylation R-HSA-199920 1.527368e-01 0.816 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.890199e-01 0.723 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.890199e-01 0.723 0 0
Netrin mediated repulsion signals R-HSA-418886 1.890199e-01 0.723 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.890199e-01 0.723 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.890199e-01 0.723 0 0
Disinhibition of SNARE formation R-HSA-114516 1.890199e-01 0.723 0 0
Signaling by APC mutants R-HSA-4839744 1.590779e-01 0.798 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.590779e-01 0.798 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.590779e-01 0.798 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.590779e-01 0.798 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.879944e-01 0.726 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.575691e-01 0.803 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.575691e-01 0.803 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.575691e-01 0.803 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.529876e-01 0.815 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.818320e-01 0.740 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.739505e-01 0.760 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.739505e-01 0.760 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.739505e-01 0.760 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.739505e-01 0.760 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.739505e-01 0.760 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.073645e-01 0.683 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.407374e-01 0.852 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.655718e-01 0.781 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.655718e-01 0.781 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.960100e-01 0.708 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.960100e-01 0.708 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.572041e-01 0.804 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.572041e-01 0.804 0 0
Activation of the pre-replicative complex R-HSA-68962 1.745325e-01 0.758 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.745325e-01 0.758 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.745325e-01 0.758 1 1
EGFR downregulation R-HSA-182971 1.926667e-01 0.715 0 0
HSF1-dependent transactivation R-HSA-3371571 1.777224e-01 0.750 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.917893e-01 0.717 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.063479e-01 0.685 0 0
Protein folding R-HSA-391251 1.953653e-01 0.709 0 0
Signaling by FGFR3 R-HSA-5654741 1.745338e-01 0.758 0 0
Signaling by FGFR4 R-HSA-5654743 1.468068e-01 0.833 0 0
IGF1R signaling cascade R-HSA-2428924 1.947647e-01 0.710 0 0
Specification of the neural plate border R-HSA-9834899 1.529876e-01 0.815 0 0
p75NTR signals via NF-kB R-HSA-193639 1.575691e-01 0.803 0 0
Formation of definitive endoderm R-HSA-9823730 1.739505e-01 0.760 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.471148e-01 0.832 0 0
DARPP-32 events R-HSA-180024 1.572041e-01 0.804 0 0
Signaling by ERBB2 R-HSA-1227986 1.457393e-01 0.836 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.693512e-01 0.771 0 0
Prolonged ERK activation events R-HSA-169893 1.818320e-01 0.740 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.638144e-01 0.786 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.081031e-01 0.682 0 0
G1 Phase R-HSA-69236 1.603699e-01 0.795 0 0
Cyclin D associated events in G1 R-HSA-69231 1.603699e-01 0.795 0 0
Hedgehog 'off' state R-HSA-5610787 1.643763e-01 0.784 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.890199e-01 0.723 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.490736e-01 0.827 0 0
NADPH regeneration R-HSA-389542 1.527368e-01 0.816 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.818320e-01 0.740 0 0
Passive transport by Aquaporins R-HSA-432047 2.073645e-01 0.683 0 0
PLC beta mediated events R-HSA-112043 1.573123e-01 0.803 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.045839e-01 0.689 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.572041e-01 0.804 0 0
DAG and IP3 signaling R-HSA-1489509 1.745338e-01 0.758 1 1
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.718661e-01 0.765 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.849945e-01 0.733 0 0
Regulated Necrosis R-HSA-5218859 1.710416e-01 0.767 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.470086e-01 0.833 0 0
Adaptive Immune System R-HSA-1280218 1.971889e-01 0.705 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.470086e-01 0.833 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.575691e-01 0.803 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.722594e-01 0.764 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.722594e-01 0.764 0 0
Negative regulation of FLT3 R-HSA-9706369 1.818320e-01 0.740 0 0
PECAM1 interactions R-HSA-210990 1.590779e-01 0.798 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.879944e-01 0.726 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.810337e-01 0.742 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.460221e-01 0.836 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.460221e-01 0.836 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.460221e-01 0.836 0 0
The NLRP3 inflammasome R-HSA-844456 1.529876e-01 0.815 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.890199e-01 0.723 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.879944e-01 0.726 0 0
Signaling by AXIN mutants R-HSA-4839735 1.879944e-01 0.726 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.546065e-01 0.811 0 0
Signaling by NOTCH3 R-HSA-9012852 1.546037e-01 0.811 0 0
Interleukin-1 family signaling R-HSA-446652 2.010491e-01 0.697 0 0
Hemostasis R-HSA-109582 1.428005e-01 0.845 1 0
PI Metabolism R-HSA-1483255 1.839158e-01 0.735 0 0
Glycolysis R-HSA-70171 1.643763e-01 0.784 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.718661e-01 0.765 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.053019e-01 0.688 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.718661e-01 0.765 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.857915e-01 0.731 0 0
Cilium Assembly R-HSA-5617833 2.143325e-01 0.669 0 0
Voltage gated Potassium channels R-HSA-1296072 2.157590e-01 0.666 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.184250e-01 0.661 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.184250e-01 0.661 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.184250e-01 0.661 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.184250e-01 0.661 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.184250e-01 0.661 0 0
Repression of WNT target genes R-HSA-4641265 2.184250e-01 0.661 0 0
Signaling by LTK R-HSA-9842663 2.184250e-01 0.661 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.184250e-01 0.661 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.185609e-01 0.660 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.190457e-01 0.659 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.209557e-01 0.656 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.213701e-01 0.655 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.215019e-01 0.655 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.215019e-01 0.655 0 0
RAB geranylgeranylation R-HSA-8873719 2.218238e-01 0.654 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.228025e-01 0.652 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.579570e-01 0.588 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.579570e-01 0.588 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.579570e-01 0.588 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.579570e-01 0.588 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.579570e-01 0.588 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.579570e-01 0.588 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.579570e-01 0.588 0 0
Regulation of gap junction activity R-HSA-191650 2.256772e-01 0.647 0 0
NADE modulates death signalling R-HSA-205025 2.256772e-01 0.647 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.256772e-01 0.647 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.256772e-01 0.647 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.256772e-01 0.647 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.256772e-01 0.647 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.256772e-01 0.647 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.607988e-01 0.443 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.607988e-01 0.443 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.607988e-01 0.443 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.607988e-01 0.443 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.607988e-01 0.443 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.607988e-01 0.443 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.607988e-01 0.443 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.607988e-01 0.443 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.607988e-01 0.443 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.607988e-01 0.443 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.607988e-01 0.443 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.607988e-01 0.443 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.607988e-01 0.443 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.607988e-01 0.443 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.607988e-01 0.443 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.607988e-01 0.443 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.607988e-01 0.443 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.607988e-01 0.443 0 0
Intestinal infectious diseases R-HSA-8942233 3.607988e-01 0.443 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.607988e-01 0.443 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.607988e-01 0.443 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.607988e-01 0.443 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.607988e-01 0.443 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.804826e-01 0.552 0 0
IRS activation R-HSA-74713 2.804826e-01 0.552 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.272082e-01 0.644 0 0
Type I hemidesmosome assembly R-HSA-446107 2.272082e-01 0.644 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.272082e-01 0.644 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.272082e-01 0.644 0 0
Formation of annular gap junctions R-HSA-196025 2.272082e-01 0.644 0 0
ARMS-mediated activation R-HSA-170984 2.666755e-01 0.574 0 0
Lipophagy R-HSA-9613354 2.666755e-01 0.574 0 0
ALK mutants bind TKIs R-HSA-9700645 2.666755e-01 0.574 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.349737e-01 0.475 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.349737e-01 0.475 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.349737e-01 0.475 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.493925e-01 0.347 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.493925e-01 0.347 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.493925e-01 0.347 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.493925e-01 0.347 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.493925e-01 0.347 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.493925e-01 0.347 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.493925e-01 0.347 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.500506e-01 0.602 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.500506e-01 0.602 0 0
Formation of axial mesoderm R-HSA-9796292 2.500506e-01 0.602 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.068496e-01 0.513 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.068496e-01 0.513 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.068496e-01 0.513 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.068496e-01 0.513 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.825572e-01 0.549 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.825572e-01 0.549 0 0
cGMP effects R-HSA-418457 2.825572e-01 0.549 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.881856e-01 0.411 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.881856e-01 0.411 0 0
STAT5 Activation R-HSA-9645135 3.881856e-01 0.411 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.881856e-01 0.411 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.881856e-01 0.411 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.881856e-01 0.411 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.614790e-01 0.583 0 0
GAB1 signalosome R-HSA-180292 2.614790e-01 0.583 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.472207e-01 0.459 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.472207e-01 0.459 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.472207e-01 0.459 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.264061e-01 0.645 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.264061e-01 0.645 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.264061e-01 0.645 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.156428e-01 0.501 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.156428e-01 0.501 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.896728e-01 0.538 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.896728e-01 0.538 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.482139e-01 0.605 0 0
HIV elongation arrest and recovery R-HSA-167287 2.482139e-01 0.605 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.482139e-01 0.605 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.512573e-01 0.600 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.706284e-01 0.568 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.927117e-01 0.534 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.183681e-01 0.497 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.490232e-01 0.457 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.873454e-01 0.412 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.873454e-01 0.412 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.873454e-01 0.412 0 0
ERKs are inactivated R-HSA-202670 3.873454e-01 0.412 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.394264e-01 0.357 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.394264e-01 0.357 0 0
SOS-mediated signalling R-HSA-112412 4.394264e-01 0.357 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.394264e-01 0.357 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.528403e-01 0.597 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.719466e-01 0.566 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.935503e-01 0.532 0 0
Tight junction interactions R-HSA-420029 3.183412e-01 0.497 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.183412e-01 0.497 0 0
HIV Transcription Elongation R-HSA-167169 2.721215e-01 0.565 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.721215e-01 0.565 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.721215e-01 0.565 0 0
G alpha (z) signalling events R-HSA-418597 2.368254e-01 0.626 1 1
Downstream signal transduction R-HSA-186763 3.168797e-01 0.499 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.268461e-01 0.370 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.268461e-01 0.370 0 0
Leading Strand Synthesis R-HSA-69109 4.268461e-01 0.370 0 0
Polymerase switching R-HSA-69091 4.268461e-01 0.370 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.405168e-01 0.468 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.088228e-01 0.510 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.156417e-01 0.381 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.056534e-01 0.392 0 0
Telomere Extension By Telomerase R-HSA-171319 3.966142e-01 0.402 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.966142e-01 0.402 0 0
Stabilization of p53 R-HSA-69541 3.806409e-01 0.419 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.484286e-01 0.348 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.484286e-01 0.348 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.345964e-01 0.362 0 0
Signaling by NOTCH4 R-HSA-9013694 3.429113e-01 0.465 0 0
Signaling by FGFR2 R-HSA-5654738 3.375953e-01 0.472 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.362236e-01 0.360 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.362236e-01 0.360 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.487374e-01 0.348 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.487374e-01 0.348 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.220287e-01 0.375 0 0
Neutrophil degranulation R-HSA-6798695 4.354109e-01 0.361 0 0
G1/S Transition R-HSA-69206 3.494905e-01 0.457 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.538283e-01 0.595 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.156417e-01 0.381 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.156417e-01 0.381 0 0
Adipogenesis R-HSA-9843745 3.562879e-01 0.448 0 0
Circadian clock R-HSA-9909396 3.684287e-01 0.434 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.310984e-01 0.636 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.614790e-01 0.583 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.512573e-01 0.600 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.512573e-01 0.600 0 0
Signaling by SCF-KIT R-HSA-1433557 2.357544e-01 0.628 0 0
Nucleotide Excision Repair R-HSA-5696398 3.864477e-01 0.413 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.614790e-01 0.583 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.310984e-01 0.636 0 0
DNA Damage Bypass R-HSA-73893 2.366084e-01 0.626 0 0
Ribosome-associated quality control R-HSA-9948299 3.005235e-01 0.522 0 0
Signaling by FGFR1 R-HSA-5654736 2.526816e-01 0.597 0 0
Extension of Telomeres R-HSA-180786 4.162127e-01 0.381 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.824356e-01 0.417 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.429113e-01 0.465 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.473062e-01 0.349 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.666755e-01 0.574 0 0
Activation of GABAB receptors R-HSA-991365 3.321904e-01 0.479 0 0
Signal attenuation R-HSA-74749 3.068496e-01 0.513 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.824356e-01 0.417 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.802347e-01 0.552 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.001637e-01 0.398 0 0
Frs2-mediated activation R-HSA-170968 2.500506e-01 0.602 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.526816e-01 0.597 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.484286e-01 0.348 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.272082e-01 0.644 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.068496e-01 0.513 0 0
PI3K Cascade R-HSA-109704 3.667048e-01 0.436 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.256772e-01 0.647 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.349737e-01 0.475 0 0
Formation of apoptosome R-HSA-111458 3.068496e-01 0.513 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.429297e-01 0.615 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.394264e-01 0.357 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.719466e-01 0.566 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.442862e-01 0.463 0 0
DNA strand elongation R-HSA-69190 3.405168e-01 0.468 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.156417e-01 0.381 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.588220e-01 0.445 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.317582e-01 0.479 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.719466e-01 0.566 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.487374e-01 0.348 0 0
PTEN Regulation R-HSA-6807070 3.866695e-01 0.413 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.490232e-01 0.457 0 0
Killing mechanisms R-HSA-9664420 3.490232e-01 0.457 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.719466e-01 0.566 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.405168e-01 0.468 0 0
GABA B receptor activation R-HSA-977444 3.321904e-01 0.479 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.375953e-01 0.472 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.765298e-01 0.424 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.704183e-01 0.431 0 0
HIV Life Cycle R-HSA-162587 2.462648e-01 0.609 0 0
Dopamine receptors R-HSA-390651 2.256772e-01 0.647 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.804826e-01 0.552 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.666755e-01 0.574 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.614790e-01 0.583 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.429297e-01 0.615 0 0
NF-kB is activated and signals survival R-HSA-209560 3.873454e-01 0.412 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.268461e-01 0.370 0 0
GABA receptor activation R-HSA-977443 3.194130e-01 0.496 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.345964e-01 0.362 0 0
Cellular response to starvation R-HSA-9711097 2.558087e-01 0.592 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.301179e-01 0.366 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.930896e-01 0.533 0 0
Cellular response to chemical stress R-HSA-9711123 2.869099e-01 0.542 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.272082e-01 0.644 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.118594e-01 0.506 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.490232e-01 0.457 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.162127e-01 0.381 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.059767e-01 0.391 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.449660e-01 0.352 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.579425e-01 0.588 0 0
Signaling by WNT in cancer R-HSA-4791275 3.405168e-01 0.468 0 0
Signaling by Hedgehog R-HSA-5358351 3.005235e-01 0.522 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.666755e-01 0.574 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.825572e-01 0.549 0 0
Abacavir transmembrane transport R-HSA-2161517 3.881856e-01 0.411 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.512573e-01 0.600 1 1
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.942747e-01 0.404 0 0
Ion homeostasis R-HSA-5578775 3.603146e-01 0.443 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.706284e-01 0.568 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.824356e-01 0.417 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.364250e-01 0.473 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.310984e-01 0.636 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.927117e-01 0.534 0 0
Signal transduction by L1 R-HSA-445144 3.183681e-01 0.497 0 0
Interleukin-2 signaling R-HSA-9020558 3.472207e-01 0.459 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.500506e-01 0.602 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.490232e-01 0.457 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.268461e-01 0.370 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.362236e-01 0.360 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.804826e-01 0.552 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.340330e-01 0.631 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.873454e-01 0.412 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.643635e-01 0.438 0 0
Signaling by TGFB family members R-HSA-9006936 4.145671e-01 0.382 0 0
Cardiogenesis R-HSA-9733709 3.643635e-01 0.438 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.726039e-01 0.564 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.804826e-01 0.552 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.918154e-01 0.535 0 0
Interferon Signaling R-HSA-913531 2.853070e-01 0.545 0 0
Signaling by PTK6 R-HSA-8848021 3.718901e-01 0.430 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.718901e-01 0.430 0 0
rRNA processing R-HSA-72312 3.089387e-01 0.510 0 0
Rab regulation of trafficking R-HSA-9007101 2.441842e-01 0.612 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.111508e-01 0.507 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.822773e-01 0.549 0 0
G-protein beta:gamma signalling R-HSA-397795 3.643635e-01 0.438 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.715290e-01 0.566 0 0
Signaling by ERBB4 R-HSA-1236394 3.429113e-01 0.465 0 0
NGF-stimulated transcription R-HSA-9031628 3.279105e-01 0.484 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.812261e-01 0.551 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.220174e-01 0.492 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.579570e-01 0.588 0 0
Inhibition of PKR R-HSA-169131 2.579570e-01 0.588 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.256772e-01 0.647 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.607988e-01 0.443 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.607988e-01 0.443 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.272082e-01 0.644 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.666755e-01 0.574 0 0
Unwinding of DNA R-HSA-176974 2.666755e-01 0.574 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.349737e-01 0.475 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.493925e-01 0.347 0 0
C6 deamination of adenosine R-HSA-75102 4.493925e-01 0.347 0 0
Interleukin-33 signaling R-HSA-9014843 4.493925e-01 0.347 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.493925e-01 0.347 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.500506e-01 0.602 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.472207e-01 0.459 0 0
Bicarbonate transporters R-HSA-425381 3.472207e-01 0.459 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.490232e-01 0.457 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.490232e-01 0.457 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.394264e-01 0.357 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.719466e-01 0.566 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.715290e-01 0.566 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.966142e-01 0.402 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.607053e-01 0.584 0 0
Amine ligand-binding receptors R-HSA-375280 3.734603e-01 0.428 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.028892e-01 0.395 0 0
Diseases of Immune System R-HSA-5260271 4.028892e-01 0.395 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.664658e-01 0.436 0 0
Ion channel transport R-HSA-983712 3.845798e-01 0.415 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.664658e-01 0.436 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.279105e-01 0.484 0 0
MAP kinase activation R-HSA-450294 3.367377e-01 0.473 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.864477e-01 0.413 0 0
Nephrin family interactions R-HSA-373753 3.183681e-01 0.497 0 0
Platelet sensitization by LDL R-HSA-432142 2.614790e-01 0.583 0 0
Protein methylation R-HSA-8876725 3.156428e-01 0.501 0 0
RUNX2 regulates bone development R-HSA-8941326 3.146085e-01 0.502 0 0
Suppression of apoptosis R-HSA-9635465 3.472207e-01 0.459 0 0
tRNA processing in the nucleus R-HSA-6784531 3.542429e-01 0.451 0 0
Formation of the nephric duct R-HSA-9830364 3.183412e-01 0.497 0 0
Interleukin-1 processing R-HSA-448706 2.666755e-01 0.574 0 0
OAS antiviral response R-HSA-8983711 4.268461e-01 0.370 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.156417e-01 0.381 0 0
Syndecan interactions R-HSA-3000170 4.345964e-01 0.362 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.308847e-01 0.480 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.822506e-01 0.418 0 0
Inflammasomes R-HSA-622312 3.966142e-01 0.402 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.607988e-01 0.443 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.804826e-01 0.552 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.349737e-01 0.475 0 0
DSCAM interactions R-HSA-376172 4.493925e-01 0.347 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.068496e-01 0.513 0 0
Formation of the anterior neural plate R-HSA-9823739 3.156428e-01 0.501 0 0
Disorders of Developmental Biology R-HSA-9675151 3.824356e-01 0.417 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.643635e-01 0.438 0 0
Diseases of DNA repair R-HSA-9675135 2.900115e-01 0.538 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.473794e-01 0.459 0 0
Signaling by ALK R-HSA-201556 3.806409e-01 0.419 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.804826e-01 0.552 0 0
Co-inhibition by BTLA R-HSA-9927353 2.804826e-01 0.552 0 0
Sodium/Proton exchangers R-HSA-425986 2.272082e-01 0.644 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.349737e-01 0.475 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.493925e-01 0.347 0 0
Glucose metabolism R-HSA-70326 4.000008e-01 0.398 0 0
Maturation of nucleoprotein R-HSA-9694631 2.896728e-01 0.538 0 0
Signal regulatory protein family interactions R-HSA-391160 2.825572e-01 0.549 0 0
Pervasive developmental disorders R-HSA-9005895 4.268461e-01 0.370 0 0
Disorders of Nervous System Development R-HSA-9697154 4.268461e-01 0.370 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.268461e-01 0.370 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.900115e-01 0.538 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.484286e-01 0.348 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.535652e-01 0.343 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.535652e-01 0.343 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.599914e-01 0.337 0 0
RNA Polymerase III Transcription R-HSA-74158 4.599914e-01 0.337 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.599914e-01 0.337 0 0
GPVI-mediated activation cascade R-HSA-114604 4.599914e-01 0.337 0 0
FLT3 signaling in disease R-HSA-9682385 4.599914e-01 0.337 0 0
Transcription of the HIV genome R-HSA-167172 4.609331e-01 0.336 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.632181e-01 0.334 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.632181e-01 0.334 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.654090e-01 0.332 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.654090e-01 0.332 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.654090e-01 0.332 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.664895e-01 0.331 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.806099e-01 0.318 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.806099e-01 0.318 0 0
Other interleukin signaling R-HSA-449836 4.806099e-01 0.318 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.806099e-01 0.318 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.835326e-01 0.316 0 0
RSK activation R-HSA-444257 4.882207e-01 0.311 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.882207e-01 0.311 0 0
Activation of RAS in B cells R-HSA-1169092 4.882207e-01 0.311 0 0
MET receptor recycling R-HSA-8875656 4.882207e-01 0.311 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.882207e-01 0.311 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.882207e-01 0.311 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.882207e-01 0.311 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.882207e-01 0.311 0 0
Co-stimulation by ICOS R-HSA-9927354 4.882207e-01 0.311 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.882207e-01 0.311 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.882207e-01 0.311 0 0
Interleukin-18 signaling R-HSA-9012546 4.882207e-01 0.311 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.906076e-01 0.309 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.913920e-01 0.309 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.913920e-01 0.309 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 4.913920e-01 0.309 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.913920e-01 0.309 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.913920e-01 0.309 0 0
Host Interactions of HIV factors R-HSA-162909 4.929287e-01 0.307 0 0
Interleukin-17 signaling R-HSA-448424 4.962537e-01 0.304 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.977937e-01 0.303 0 0
Vesicle-mediated transport R-HSA-5653656 5.002917e-01 0.301 0 0
Removal of the Flap Intermediate R-HSA-69166 5.027797e-01 0.299 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.027797e-01 0.299 0 0
Physiological factors R-HSA-5578768 5.027797e-01 0.299 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.027797e-01 0.299 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.031729e-01 0.298 0 0
IRS-mediated signalling R-HSA-112399 5.036508e-01 0.298 0 0
Insulin receptor signalling cascade R-HSA-74751 5.089183e-01 0.293 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.089183e-01 0.293 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.120251e-01 0.291 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.120251e-01 0.291 0 0
Protein hydroxylation R-HSA-9629569 5.120251e-01 0.291 0 0
HIV Infection R-HSA-162906 5.120448e-01 0.291 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.147138e-01 0.288 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.156891e-01 0.288 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.190059e-01 0.285 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.190059e-01 0.285 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.190059e-01 0.285 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.190059e-01 0.285 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.190059e-01 0.285 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.190059e-01 0.285 0 0
Immune System R-HSA-168256 5.216722e-01 0.283 1 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.257115e-01 0.279 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.257115e-01 0.279 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.257115e-01 0.279 0 0
Classical Kir channels R-HSA-1296053 5.257115e-01 0.279 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.257115e-01 0.279 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.257115e-01 0.279 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.257115e-01 0.279 0 0
Invadopodia formation R-HSA-8941237 5.257115e-01 0.279 0 0
MET interacts with TNS proteins R-HSA-8875513 5.257115e-01 0.279 0 0
Intracellular oxygen transport R-HSA-8981607 5.257115e-01 0.279 0 0
Histamine receptors R-HSA-390650 5.257115e-01 0.279 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.257115e-01 0.279 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.342623e-01 0.272 0 0
WNT mediated activation of DVL R-HSA-201688 5.342623e-01 0.272 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.342623e-01 0.272 0 0
mRNA Editing R-HSA-75072 5.342623e-01 0.272 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.342623e-01 0.272 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.342623e-01 0.272 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.381446e-01 0.269 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.387584e-01 0.269 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.387584e-01 0.269 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.387584e-01 0.269 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.387584e-01 0.269 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.387584e-01 0.269 0 0
p38MAPK events R-HSA-171007 5.387584e-01 0.269 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.387584e-01 0.269 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.387584e-01 0.269 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.425392e-01 0.266 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.425392e-01 0.266 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.425392e-01 0.266 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.425392e-01 0.266 0 0
Lagging Strand Synthesis R-HSA-69186 5.425392e-01 0.266 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.425392e-01 0.266 0 0
Signalling to RAS R-HSA-167044 5.425392e-01 0.266 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.425392e-01 0.266 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.425392e-01 0.266 0 0
ERK/MAPK targets R-HSA-198753 5.425392e-01 0.266 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.459616e-01 0.263 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.459616e-01 0.263 0 0
Toll-like Receptor Cascades R-HSA-168898 5.475649e-01 0.262 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.478425e-01 0.261 0 0
Ca2+ pathway R-HSA-4086398 5.480973e-01 0.261 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.491333e-01 0.260 0 0
Viral Infection Pathways R-HSA-9824446 5.504984e-01 0.259 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.521083e-01 0.258 0 0
Attenuation phase R-HSA-3371568 5.521083e-01 0.258 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.521083e-01 0.258 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.521083e-01 0.258 0 0
Interleukin-2 family signaling R-HSA-451927 5.521083e-01 0.258 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.549210e-01 0.256 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.549210e-01 0.256 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.575959e-01 0.254 0 0
Signaling by FGFR R-HSA-190236 5.591418e-01 0.252 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.720412e-01 0.243 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.720412e-01 0.243 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.720412e-01 0.243 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.720412e-01 0.243 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.720412e-01 0.243 0 0
Dual Incision in GG-NER R-HSA-5696400 5.729533e-01 0.242 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.729533e-01 0.242 0 0
Signaling by NOTCH2 R-HSA-1980145 5.729533e-01 0.242 0 0
Phosphorylation of the APC/C R-HSA-176412 5.731946e-01 0.242 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.731946e-01 0.242 0 0
Activation of SMO R-HSA-5635838 5.731946e-01 0.242 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.740853e-01 0.241 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.740853e-01 0.241 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.754220e-01 0.240 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.773768e-01 0.239 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.773768e-01 0.239 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.773768e-01 0.239 0 0
PI3K/AKT activation R-HSA-198203 5.773768e-01 0.239 0 0
Pexophagy R-HSA-9664873 5.773768e-01 0.239 0 0
Inositol phosphate metabolism R-HSA-1483249 5.776091e-01 0.238 0 0
HCN channels R-HSA-1296061 5.914558e-01 0.228 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.914558e-01 0.228 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.914558e-01 0.228 0 0
Nucleotide catabolism defects R-HSA-9735786 5.914558e-01 0.228 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.914558e-01 0.228 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.914558e-01 0.228 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.914558e-01 0.228 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.914558e-01 0.228 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.914558e-01 0.228 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.914558e-01 0.228 0 0
Alanine metabolism R-HSA-8964540 5.914558e-01 0.228 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.914558e-01 0.228 0 0
Transmission across Electrical Synapses R-HSA-112307 5.914558e-01 0.228 0 0
Sensory perception of sour taste R-HSA-9729555 5.914558e-01 0.228 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.914558e-01 0.228 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.914558e-01 0.228 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.955378e-01 0.225 0 0
Developmental Cell Lineages R-HSA-9734767 5.958702e-01 0.225 0 0
Integration of energy metabolism R-HSA-163685 5.971175e-01 0.224 0 0
Signaling by Erythropoietin R-HSA-9006335 5.975758e-01 0.224 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.975758e-01 0.224 0 0
Late endosomal microautophagy R-HSA-9615710 5.975758e-01 0.224 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.975758e-01 0.224 0 0
Platelet calcium homeostasis R-HSA-418360 5.975758e-01 0.224 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.975758e-01 0.224 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.004426e-01 0.222 0 0
FGFR2 alternative splicing R-HSA-6803529 6.004426e-01 0.222 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.004426e-01 0.222 0 0
Interleukin-1 signaling R-HSA-9020702 6.020584e-01 0.220 0 0
Phase 2 - plateau phase R-HSA-5576893 6.059807e-01 0.218 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.059807e-01 0.218 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.059807e-01 0.218 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.059807e-01 0.218 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.059807e-01 0.218 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.138035e-01 0.212 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.139523e-01 0.212 0 0
TNF signaling R-HSA-75893 6.142643e-01 0.212 0 0
Degradation of CDH1 R-HSA-9766229 6.150569e-01 0.211 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.174912e-01 0.209 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.174912e-01 0.209 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.174912e-01 0.209 0 0
Formation of the posterior neural plate R-HSA-9832991 6.174912e-01 0.209 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.174912e-01 0.209 0 0
Prostanoid ligand receptors R-HSA-391908 6.174912e-01 0.209 0 0
LGI-ADAM interactions R-HSA-5682910 6.174912e-01 0.209 0 0
G1/S-Specific Transcription R-HSA-69205 6.186273e-01 0.209 0 0
Growth hormone receptor signaling R-HSA-982772 6.276760e-01 0.202 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.302037e-01 0.201 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.302037e-01 0.201 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.370471e-01 0.196 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.370471e-01 0.196 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.370471e-01 0.196 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.370471e-01 0.196 0 0
Budding and maturation of HIV virion R-HSA-162588 6.457206e-01 0.190 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.462371e-01 0.190 0 0
Activation of AMPA receptors R-HSA-399710 6.480902e-01 0.188 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.480902e-01 0.188 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.480902e-01 0.188 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.480902e-01 0.188 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.480902e-01 0.188 0 0
Activation of AKT2 R-HSA-165158 6.480902e-01 0.188 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.480902e-01 0.188 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.480902e-01 0.188 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.480902e-01 0.188 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.480902e-01 0.188 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.480902e-01 0.188 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.480902e-01 0.188 0 0
Interleukin-36 pathway R-HSA-9014826 6.480902e-01 0.188 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.480902e-01 0.188 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.480902e-01 0.188 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.480902e-01 0.188 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.536927e-01 0.185 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.536927e-01 0.185 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.536927e-01 0.185 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.546087e-01 0.184 0 0
Integration of provirus R-HSA-162592 6.546087e-01 0.184 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.546087e-01 0.184 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.546087e-01 0.184 0 0
Sodium/Calcium exchangers R-HSA-425561 6.546087e-01 0.184 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.546087e-01 0.184 0 0
Signaling by MET R-HSA-6806834 6.601260e-01 0.180 0 0
MET promotes cell motility R-HSA-8875878 6.613979e-01 0.180 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.618868e-01 0.179 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.663564e-01 0.176 0 0
PKA activation in glucagon signalling R-HSA-164378 6.663564e-01 0.176 0 0
Mismatch Repair R-HSA-5358508 6.663564e-01 0.176 0 0
PKA activation R-HSA-163615 6.663564e-01 0.176 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.663564e-01 0.176 0 0
Tie2 Signaling R-HSA-210993 6.663564e-01 0.176 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.663564e-01 0.176 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.663564e-01 0.176 0 0
Regulation of beta-cell development R-HSA-186712 6.669774e-01 0.176 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.683849e-01 0.175 0 0
Orc1 removal from chromatin R-HSA-68949 6.706322e-01 0.174 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.748153e-01 0.171 0 0
Signaling by FGFR in disease R-HSA-1226099 6.771384e-01 0.169 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.784614e-01 0.168 0 0
Interleukin-7 signaling R-HSA-1266695 6.784614e-01 0.168 0 0
Selenoamino acid metabolism R-HSA-2408522 6.870595e-01 0.163 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.887892e-01 0.162 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.887892e-01 0.162 0 0
Interleukin-15 signaling R-HSA-8983432 6.887892e-01 0.162 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.887892e-01 0.162 0 0
Estrogen biosynthesis R-HSA-193144 6.887892e-01 0.162 0 0
Regulation of IFNG signaling R-HSA-877312 6.887892e-01 0.162 0 0
Parasitic Infection Pathways R-HSA-9824443 6.893427e-01 0.162 0 0
Leishmania infection R-HSA-9658195 6.893427e-01 0.162 0 0
Nuclear RNA decay R-HSA-9930044 6.900754e-01 0.161 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.937004e-01 0.159 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.937004e-01 0.159 0 0
Regulation of signaling by CBL R-HSA-912631 6.938985e-01 0.159 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.938985e-01 0.159 0 0
Translesion Synthesis by POLH R-HSA-110320 6.938985e-01 0.159 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.938985e-01 0.159 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.938985e-01 0.159 0 0
G alpha (s) signalling events R-HSA-418555 6.966181e-01 0.157 0 0
Plus-strand DNA synthesis R-HSA-164525 6.968764e-01 0.157 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.968764e-01 0.157 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.968764e-01 0.157 0 0
PKB-mediated events R-HSA-109703 6.968764e-01 0.157 0 0
PDE3B signalling R-HSA-165160 6.968764e-01 0.157 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.968764e-01 0.157 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.968764e-01 0.157 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.968764e-01 0.157 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.968764e-01 0.157 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.968764e-01 0.157 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.968764e-01 0.157 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.968764e-01 0.157 0 0
Phosphorylation of Emi1 R-HSA-176417 6.968764e-01 0.157 0 0
Formation of the Editosome R-HSA-75094 6.968764e-01 0.157 0 0
Ceramide signalling R-HSA-193681 6.968764e-01 0.157 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.968764e-01 0.157 0 0
Synthesis of PS R-HSA-1483101 6.968764e-01 0.157 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.968764e-01 0.157 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.968764e-01 0.157 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.968764e-01 0.157 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.968764e-01 0.157 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.968764e-01 0.157 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.010359e-01 0.154 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.019656e-01 0.154 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.019656e-01 0.154 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.107776e-01 0.148 0 0
Platelet degranulation R-HSA-114608 7.127218e-01 0.147 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.196861e-01 0.143 0 0
Signaling by NODAL R-HSA-1181150 7.196861e-01 0.143 0 0
Negative regulation of MET activity R-HSA-6807004 7.196861e-01 0.143 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.201336e-01 0.143 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.201336e-01 0.143 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.201336e-01 0.143 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.201336e-01 0.143 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.201336e-01 0.143 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.201336e-01 0.143 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.201336e-01 0.143 0 0
Interleukin-6 signaling R-HSA-1059683 7.201336e-01 0.143 0 0
SARS-CoV Infections R-HSA-9679506 7.204979e-01 0.142 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.230823e-01 0.141 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.242023e-01 0.140 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.242023e-01 0.140 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.242023e-01 0.140 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.248633e-01 0.140 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.249372e-01 0.140 1 0
Metal ion SLC transporters R-HSA-425410 7.282969e-01 0.138 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.297633e-01 0.137 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.304858e-01 0.136 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.304858e-01 0.136 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.304858e-01 0.136 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.304858e-01 0.136 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.366540e-01 0.133 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.374236e-01 0.132 0 0
Translation of Structural Proteins R-HSA-9683701 7.374236e-01 0.132 0 0
IRE1alpha activates chaperones R-HSA-381070 7.385809e-01 0.132 0 0
Hedgehog 'on' state R-HSA-5632684 7.388598e-01 0.131 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.389016e-01 0.131 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.389016e-01 0.131 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.389016e-01 0.131 0 0
Uncoating of the HIV Virion R-HSA-162585 7.389016e-01 0.131 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.389016e-01 0.131 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.389016e-01 0.131 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.389016e-01 0.131 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.389016e-01 0.131 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.389016e-01 0.131 0 0
Lipid particle organization R-HSA-8964572 7.389016e-01 0.131 0 0
VLDL assembly R-HSA-8866423 7.389016e-01 0.131 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.437502e-01 0.129 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.437502e-01 0.129 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.437502e-01 0.129 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.437502e-01 0.129 0 0
Basigin interactions R-HSA-210991 7.437502e-01 0.129 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.451800e-01 0.128 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.451800e-01 0.128 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.451800e-01 0.128 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.451800e-01 0.128 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.451800e-01 0.128 0 0
Regulation of insulin secretion R-HSA-422356 7.469074e-01 0.127 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.470627e-01 0.127 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.487712e-01 0.126 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.487712e-01 0.126 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.487712e-01 0.126 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.487712e-01 0.126 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.487712e-01 0.126 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.487712e-01 0.126 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.487712e-01 0.126 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.487712e-01 0.126 0 0
Prolactin receptor signaling R-HSA-1170546 7.487712e-01 0.126 0 0
HDL assembly R-HSA-8963896 7.487712e-01 0.126 0 0
Zinc transporters R-HSA-435354 7.487712e-01 0.126 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.487712e-01 0.126 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.487712e-01 0.126 0 0
PERK regulates gene expression R-HSA-381042 7.492019e-01 0.125 0 0
Regulation of CDH1 Function R-HSA-9764561 7.516474e-01 0.124 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.543878e-01 0.122 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.548545e-01 0.122 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.548545e-01 0.122 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.622712e-01 0.118 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.648478e-01 0.116 0 0
mRNA Capping R-HSA-72086 7.649169e-01 0.116 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.649169e-01 0.116 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.649169e-01 0.116 0 0
Platelet homeostasis R-HSA-418346 7.656111e-01 0.116 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.661368e-01 0.116 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.661368e-01 0.116 0 0
HSF1 activation R-HSA-3371511 7.669344e-01 0.115 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.669344e-01 0.115 0 0
Erythropoietin activates RAS R-HSA-9027284 7.748499e-01 0.111 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.748499e-01 0.111 0 0
Translesion synthesis by REV1 R-HSA-110312 7.748499e-01 0.111 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.748499e-01 0.111 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.748499e-01 0.111 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.748499e-01 0.111 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.748499e-01 0.111 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.748499e-01 0.111 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.751026e-01 0.111 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.751026e-01 0.111 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.751026e-01 0.111 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.751026e-01 0.111 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.751026e-01 0.111 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.751026e-01 0.111 0 0
Recycling of eIF2:GDP R-HSA-72731 7.751026e-01 0.111 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.751026e-01 0.111 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.751026e-01 0.111 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.751026e-01 0.111 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.751026e-01 0.111 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.751026e-01 0.111 0 0
LDL remodeling R-HSA-8964041 7.751026e-01 0.111 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.751026e-01 0.111 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.751026e-01 0.111 0 0
CHL1 interactions R-HSA-447041 7.751026e-01 0.111 0 0
Synthesis of DNA R-HSA-69239 7.761005e-01 0.110 0 0
DAP12 signaling R-HSA-2424491 7.834395e-01 0.106 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.834395e-01 0.106 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.834395e-01 0.106 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.834395e-01 0.106 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.836976e-01 0.106 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.844578e-01 0.105 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.869034e-01 0.104 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.869034e-01 0.104 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.869034e-01 0.104 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.899764e-01 0.102 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.950947e-01 0.100 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.975451e-01 0.098 0 0
Translesion synthesis by POLI R-HSA-5656121 7.985288e-01 0.098 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.985288e-01 0.098 0 0
Atorvastatin ADME R-HSA-9754706 7.985288e-01 0.098 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.985288e-01 0.098 0 0
Regulation of BACH1 activity R-HSA-9708530 7.985288e-01 0.098 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.985288e-01 0.098 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.004295e-01 0.097 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.004295e-01 0.097 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.004295e-01 0.097 0 0
PPARA activates gene expression R-HSA-1989781 8.006455e-01 0.097 0 0
Cargo concentration in the ER R-HSA-5694530 8.007808e-01 0.096 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.007808e-01 0.096 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.026112e-01 0.095 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.026112e-01 0.095 0 0
Aquaporin-mediated transport R-HSA-445717 8.055509e-01 0.094 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.055509e-01 0.094 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.061159e-01 0.094 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.061159e-01 0.094 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.061159e-01 0.094 0 0
Formation of the ureteric bud R-HSA-9830674 8.061159e-01 0.094 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.061159e-01 0.094 0 0
Biosynthesis of maresins R-HSA-9018682 8.061159e-01 0.094 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.062861e-01 0.094 0 0
Minus-strand DNA synthesis R-HSA-164516 8.062861e-01 0.094 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.062861e-01 0.094 0 0
phospho-PLA2 pathway R-HSA-111995 8.062861e-01 0.094 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.062861e-01 0.094 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.062861e-01 0.094 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.062861e-01 0.094 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.062861e-01 0.094 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.062861e-01 0.094 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.062861e-01 0.094 0 0
Interleukin-9 signaling R-HSA-8985947 8.062861e-01 0.094 0 0
Regulation by c-FLIP R-HSA-3371378 8.062861e-01 0.094 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.062861e-01 0.094 0 0
Dimerization of procaspase-8 R-HSA-69416 8.062861e-01 0.094 0 0
Alpha-defensins R-HSA-1462054 8.062861e-01 0.094 0 0
Interleukin-23 signaling R-HSA-9020933 8.062861e-01 0.094 0 0
Translation of Structural Proteins R-HSA-9694635 8.126313e-01 0.090 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.139935e-01 0.089 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.142013e-01 0.089 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.142013e-01 0.089 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.162585e-01 0.088 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.170499e-01 0.088 0 0
Signaling by PDGF R-HSA-186797 8.175380e-01 0.087 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.199718e-01 0.086 0 0
Translesion synthesis by POLK R-HSA-5655862 8.199718e-01 0.086 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.199718e-01 0.086 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.199718e-01 0.086 0 0
Synthesis of PG R-HSA-1483148 8.199718e-01 0.086 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.238469e-01 0.084 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.238469e-01 0.084 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.272141e-01 0.082 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.283856e-01 0.082 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.283856e-01 0.082 0 0
Signaling by Insulin receptor R-HSA-74752 8.299186e-01 0.081 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.320788e-01 0.080 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.331474e-01 0.079 0 0
CASP8 activity is inhibited R-HSA-5218900 8.331474e-01 0.079 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.331474e-01 0.079 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.331474e-01 0.079 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.331474e-01 0.079 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.331474e-01 0.079 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.331474e-01 0.079 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.331474e-01 0.079 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.331474e-01 0.079 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.331474e-01 0.079 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.331474e-01 0.079 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.331474e-01 0.079 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.331474e-01 0.079 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.391074e-01 0.076 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.393437e-01 0.076 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.393437e-01 0.076 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.393437e-01 0.076 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.393437e-01 0.076 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.393437e-01 0.076 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.393437e-01 0.076 0 0
Ion transport by P-type ATPases R-HSA-936837 8.397945e-01 0.076 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.401728e-01 0.076 0 0
G protein gated Potassium channels R-HSA-1296059 8.401728e-01 0.076 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.401728e-01 0.076 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.401728e-01 0.076 0 0
Maturation of spike protein R-HSA-9694548 8.415040e-01 0.075 0 0
Heme degradation R-HSA-189483 8.461244e-01 0.073 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.508704e-01 0.070 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.537851e-01 0.069 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.537851e-01 0.069 0 0
Binding and entry of HIV virion R-HSA-173107 8.562853e-01 0.067 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.562853e-01 0.067 0 0
DNA replication initiation R-HSA-68952 8.562853e-01 0.067 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.562853e-01 0.067 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.562853e-01 0.067 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.562853e-01 0.067 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.562853e-01 0.067 0 0
2-LTR circle formation R-HSA-164843 8.562853e-01 0.067 0 0
Maturation of spike protein R-HSA-9683686 8.562853e-01 0.067 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.562853e-01 0.067 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.562853e-01 0.067 0 0
Josephin domain DUBs R-HSA-5689877 8.562853e-01 0.067 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.562853e-01 0.067 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.568063e-01 0.067 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.568063e-01 0.067 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.568063e-01 0.067 0 0
Dual incision in TC-NER R-HSA-6782135 8.602986e-01 0.065 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.602986e-01 0.065 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.619183e-01 0.065 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.689257e-01 0.061 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.689257e-01 0.061 0 0
Kidney development R-HSA-9830369 8.690891e-01 0.061 0 0
The phototransduction cascade R-HSA-2514856 8.721230e-01 0.059 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.725166e-01 0.059 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.725166e-01 0.059 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.725166e-01 0.059 0 0
GPCR downstream signalling R-HSA-388396 8.734871e-01 0.059 1 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.759718e-01 0.058 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.759718e-01 0.058 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.762157e-01 0.057 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.762157e-01 0.057 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.762157e-01 0.057 0 0
vRNA Synthesis R-HSA-192814 8.762157e-01 0.057 0 0
Chylomicron assembly R-HSA-8963888 8.762157e-01 0.057 0 0
Synthesis of PI R-HSA-1483226 8.762157e-01 0.057 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.762157e-01 0.057 0 0
Transport of RCbl within the body R-HSA-9758890 8.762157e-01 0.057 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.762157e-01 0.057 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.762157e-01 0.057 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.762157e-01 0.057 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.762157e-01 0.057 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.762157e-01 0.057 0 0
Mitochondrial biogenesis R-HSA-1592230 8.770801e-01 0.057 0 0
Interferon gamma signaling R-HSA-877300 8.787339e-01 0.056 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.816894e-01 0.055 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.816894e-01 0.055 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.824285e-01 0.054 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.859482e-01 0.053 0 0
DAP12 interactions R-HSA-2172127 8.859482e-01 0.053 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.866248e-01 0.052 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.866248e-01 0.052 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.889771e-01 0.051 0 0
Smooth Muscle Contraction R-HSA-445355 8.906448e-01 0.050 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.930102e-01 0.049 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.933832e-01 0.049 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.933832e-01 0.049 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.933832e-01 0.049 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.933832e-01 0.049 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.933832e-01 0.049 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.933832e-01 0.049 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.933832e-01 0.049 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.945032e-01 0.048 0 0
Leishmania phagocytosis R-HSA-9664417 8.945032e-01 0.048 0 0
Parasite infection R-HSA-9664407 8.945032e-01 0.048 0 0
G-protein activation R-HSA-202040 8.992728e-01 0.046 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.992728e-01 0.046 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.992728e-01 0.046 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.992728e-01 0.046 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.022734e-01 0.045 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.022734e-01 0.045 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.059631e-01 0.043 0 0
Gastrulation R-HSA-9758941 9.062613e-01 0.043 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.068327e-01 0.042 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.081706e-01 0.042 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.081706e-01 0.042 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.081706e-01 0.042 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.081706e-01 0.042 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.081706e-01 0.042 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.081706e-01 0.042 0 0
MET activates RAS signaling R-HSA-8851805 9.081706e-01 0.042 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.081706e-01 0.042 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.081706e-01 0.042 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.081706e-01 0.042 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.081706e-01 0.042 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.105943e-01 0.041 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.110384e-01 0.040 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.130437e-01 0.040 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.130437e-01 0.040 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.190963e-01 0.037 0 0
Glycogen metabolism R-HSA-8982491 9.190963e-01 0.037 0 0
Generation of second messenger molecules R-HSA-202433 9.190963e-01 0.037 0 0
Signaling by KIT in disease R-HSA-9669938 9.207139e-01 0.036 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.207139e-01 0.036 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.207139e-01 0.036 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.207139e-01 0.036 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.207139e-01 0.036 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.207139e-01 0.036 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.209077e-01 0.036 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.209077e-01 0.036 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.209077e-01 0.036 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.209077e-01 0.036 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.209077e-01 0.036 0 0
Chylomicron remodeling R-HSA-8963901 9.209077e-01 0.036 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.209077e-01 0.036 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.209077e-01 0.036 0 0
Processing of SMDT1 R-HSA-8949664 9.209077e-01 0.036 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.209077e-01 0.036 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.209077e-01 0.036 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.263708e-01 0.033 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.272186e-01 0.033 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.297472e-01 0.032 0 0
Carnitine shuttle R-HSA-200425 9.297472e-01 0.032 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.316702e-01 0.031 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.318788e-01 0.031 0 0
Hydrolysis of LPC R-HSA-1483115 9.318788e-01 0.031 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.318788e-01 0.031 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.318788e-01 0.031 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.318788e-01 0.031 0 0
Ciprofloxacin ADME R-HSA-9793528 9.318788e-01 0.031 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.318788e-01 0.031 0 0
P2Y receptors R-HSA-417957 9.318788e-01 0.031 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.332759e-01 0.030 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.332759e-01 0.030 0 0
HIV Transcription Initiation R-HSA-167161 9.332759e-01 0.030 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.332759e-01 0.030 0 0
Intra-Golgi traffic R-HSA-6811438 9.332759e-01 0.030 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.367486e-01 0.028 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.373999e-01 0.028 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.378006e-01 0.028 0 0
Complex III assembly R-HSA-9865881 9.378006e-01 0.028 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.378006e-01 0.028 0 0
Interleukin-6 family signaling R-HSA-6783589 9.378006e-01 0.028 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.394860e-01 0.027 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.413286e-01 0.026 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.413286e-01 0.026 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.413286e-01 0.026 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.413286e-01 0.026 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.413286e-01 0.026 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.413286e-01 0.026 0 0
Signaling by Activin R-HSA-1502540 9.413286e-01 0.026 0 0
Biotin transport and metabolism R-HSA-196780 9.413286e-01 0.026 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.413286e-01 0.026 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.413286e-01 0.026 0 0
DNA Damage Reversal R-HSA-73942 9.413286e-01 0.026 0 0
PCP/CE pathway R-HSA-4086400 9.414142e-01 0.026 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.432174e-01 0.025 0 0
Hyaluronan metabolism R-HSA-2142845 9.432174e-01 0.025 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.432620e-01 0.025 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.436418e-01 0.025 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.449722e-01 0.025 0 0
Hyaluronan degradation R-HSA-2160916 9.449722e-01 0.025 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.451651e-01 0.024 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.481012e-01 0.023 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.482379e-01 0.023 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.482379e-01 0.023 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.485958e-01 0.023 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.494680e-01 0.023 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.494680e-01 0.023 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.494680e-01 0.023 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.494680e-01 0.023 0 0
Differentiation of T cells R-HSA-9945266 9.494680e-01 0.023 0 0
Fructose catabolism R-HSA-70350 9.494680e-01 0.023 0 0
Attachment and Entry R-HSA-9678110 9.494680e-01 0.023 0 0
MET activates PTK2 signaling R-HSA-8874081 9.513516e-01 0.022 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.513516e-01 0.022 0 0
Abacavir ADME R-HSA-2161522 9.513516e-01 0.022 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.513516e-01 0.022 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.543513e-01 0.020 0 0
Triglyceride catabolism R-HSA-163560 9.543513e-01 0.020 0 0
ER-Phagosome pathway R-HSA-1236974 9.549000e-01 0.020 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.550855e-01 0.020 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.550855e-01 0.020 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.564787e-01 0.019 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.564787e-01 0.019 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.564787e-01 0.019 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.564787e-01 0.019 0 0
Fibronectin matrix formation R-HSA-1566977 9.564787e-01 0.019 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.564787e-01 0.019 0 0
Coenzyme A biosynthesis R-HSA-196783 9.564787e-01 0.019 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.564787e-01 0.019 0 0
Insulin processing R-HSA-264876 9.570206e-01 0.019 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.570206e-01 0.019 0 0
Paracetamol ADME R-HSA-9753281 9.573361e-01 0.019 0 0
G alpha (q) signalling events R-HSA-416476 9.588201e-01 0.018 1 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.588249e-01 0.018 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.591189e-01 0.018 0 0
Degradation of DVL R-HSA-4641258 9.591189e-01 0.018 0 0
Cellular response to hypoxia R-HSA-1234174 9.602337e-01 0.018 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.611763e-01 0.017 0 0
Prednisone ADME R-HSA-9757110 9.620534e-01 0.017 0 0
Pyrimidine salvage R-HSA-73614 9.620534e-01 0.017 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.625170e-01 0.017 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.625170e-01 0.017 0 0
Glycogen storage diseases R-HSA-3229121 9.625170e-01 0.017 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.625170e-01 0.017 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.625170e-01 0.017 0 0
Choline catabolism R-HSA-6798163 9.625170e-01 0.017 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.633261e-01 0.016 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.633261e-01 0.016 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.633473e-01 0.016 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.635441e-01 0.016 0 0
Potential therapeutics for SARS R-HSA-9679191 9.638788e-01 0.016 0 0
Synthesis of PA R-HSA-1483166 9.646967e-01 0.016 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.672848e-01 0.014 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.677179e-01 0.014 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.677179e-01 0.014 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.677179e-01 0.014 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.677179e-01 0.014 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.677179e-01 0.014 0 0
Signaling by GPCR R-HSA-372790 9.695270e-01 0.013 1 0
Interferon alpha/beta signaling R-HSA-909733 9.695783e-01 0.013 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.701430e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.704735e-01 0.013 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.704735e-01 0.013 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.707650e-01 0.013 0 0
Phospholipid metabolism R-HSA-1483257 9.716190e-01 0.013 0 0
Integrin cell surface interactions R-HSA-216083 9.716881e-01 0.012 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.721974e-01 0.012 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.721974e-01 0.012 0 0
Methionine salvage pathway R-HSA-1237112 9.721974e-01 0.012 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.721974e-01 0.012 0 0
Azathioprine ADME R-HSA-9748787 9.730888e-01 0.012 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.738924e-01 0.011 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.739767e-01 0.011 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.739767e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.740562e-01 0.011 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.757604e-01 0.011 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.757604e-01 0.011 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.760555e-01 0.011 0 0
Glycogen synthesis R-HSA-3322077 9.760555e-01 0.011 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.760555e-01 0.011 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.760555e-01 0.011 0 0
Creatine metabolism R-HSA-71288 9.760555e-01 0.011 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.760555e-01 0.011 0 0
Keratan sulfate degradation R-HSA-2022857 9.760555e-01 0.011 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.760555e-01 0.011 0 0
Pregnenolone biosynthesis R-HSA-196108 9.760555e-01 0.011 0 0
Neddylation R-HSA-8951664 9.778801e-01 0.010 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.781810e-01 0.010 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.792194e-01 0.009 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.793784e-01 0.009 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.793784e-01 0.009 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.793784e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.797089e-01 0.009 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.798173e-01 0.009 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.814773e-01 0.008 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.814821e-01 0.008 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.822391e-01 0.008 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.822391e-01 0.008 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.822404e-01 0.008 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.822404e-01 0.008 0 0
Serine metabolism R-HSA-977347 9.822404e-01 0.008 0 0
Glutathione synthesis and recycling R-HSA-174403 9.822404e-01 0.008 0 0
Attachment and Entry R-HSA-9694614 9.822404e-01 0.008 0 0
Ribavirin ADME R-HSA-9755088 9.822404e-01 0.008 0 0
Assembly Of The HIV Virion R-HSA-175474 9.822404e-01 0.008 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.823549e-01 0.008 0 0
Surfactant metabolism R-HSA-5683826 9.834995e-01 0.007 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.835483e-01 0.007 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.841981e-01 0.007 0 0
eNOS activation R-HSA-203615 9.843776e-01 0.007 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.843776e-01 0.007 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.843776e-01 0.007 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.847053e-01 0.007 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.847053e-01 0.007 0 0
LDL clearance R-HSA-8964038 9.847053e-01 0.007 0 0
Fructose metabolism R-HSA-5652084 9.847053e-01 0.007 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.847053e-01 0.007 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.853093e-01 0.006 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.853093e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.854403e-01 0.006 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.861584e-01 0.006 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.862648e-01 0.006 0 0
Regulation of Apoptosis R-HSA-169911 9.862648e-01 0.006 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.862648e-01 0.006 0 0
TCR signaling R-HSA-202403 9.864504e-01 0.006 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.868282e-01 0.006 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.868282e-01 0.006 0 0
Interleukin-20 family signaling R-HSA-8854691 9.868282e-01 0.006 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.869278e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.879292e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.881219e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.881607e-01 0.005 0 0
CYP2E1 reactions R-HSA-211999 9.886566e-01 0.005 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.886566e-01 0.005 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.886566e-01 0.005 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.893963e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.893963e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.896658e-01 0.005 0 0
Triglyceride metabolism R-HSA-8979227 9.897291e-01 0.004 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.902312e-01 0.004 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.902312e-01 0.004 0 0
Infectious disease R-HSA-5663205 9.905755e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.906889e-01 0.004 0 0
Purine salvage R-HSA-74217 9.906889e-01 0.004 0 0
Elastic fibre formation R-HSA-1566948 9.906889e-01 0.004 0 0
Glutathione conjugation R-HSA-156590 9.907978e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.907978e-01 0.004 0 0
tRNA processing R-HSA-72306 9.910356e-01 0.004 0 0
Metabolism of porphyrins R-HSA-189445 9.912833e-01 0.004 0 0
Metabolism of cofactors R-HSA-8978934 9.912833e-01 0.004 0 0
Urea cycle R-HSA-70635 9.915874e-01 0.004 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.915874e-01 0.004 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.917597e-01 0.004 0 0
Nucleotide salvage R-HSA-8956321 9.917597e-01 0.004 0 0
Collagen degradation R-HSA-1442490 9.917597e-01 0.004 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.918269e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.918269e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.918269e-01 0.004 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.921459e-01 0.003 0 0
Mitochondrial protein import R-HSA-1268020 9.926247e-01 0.003 0 0
Cristae formation R-HSA-8949613 9.927553e-01 0.003 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.927553e-01 0.003 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.927553e-01 0.003 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.927553e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.927553e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.927553e-01 0.003 0 0
Signaling by BMP R-HSA-201451 9.927553e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.927612e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.936084e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.937097e-01 0.003 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.937097e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.937612e-01 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.942051e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.943063e-01 0.002 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.944845e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.944845e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.946116e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.946274e-01 0.002 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.946274e-01 0.002 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.946274e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.946274e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.951654e-01 0.002 0 0
Mucopolysaccharidoses R-HSA-2206281 9.953734e-01 0.002 0 0
Disease R-HSA-1643685 9.954815e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.956435e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.957944e-01 0.002 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.960159e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.960159e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.960159e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.965605e-01 0.001 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.965692e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.965692e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.967502e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.967502e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.970883e-01 0.001 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.972548e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.972933e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.973011e-01 0.001 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.974560e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.974560e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.974875e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.975098e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.975724e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.976488e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.978093e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.978685e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.980943e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.981136e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.981136e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.981136e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.981190e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.981492e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.981492e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.983259e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.983757e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.985206e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.985426e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.986013e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.986013e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.986013e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.986013e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.986013e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.986013e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.987512e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.987956e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.988223e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.989630e-01 0.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.989630e-01 0.000 0 0
RAS processing R-HSA-9648002 9.989630e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.989831e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.990048e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.990325e-01 0.000 1 0
Aflatoxin activation and detoxification R-HSA-5423646 9.992311e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.992311e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.993029e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.993029e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.993521e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.993857e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993857e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.994588e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.994745e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.994764e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.995064e-01 0.000 0 0
Defensins R-HSA-1461973 9.995092e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.995693e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.995774e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.995774e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.995774e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.995973e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996301e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.996362e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.996867e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.997303e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.997484e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997507e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.997678e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997846e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.998001e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998290e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998349e-01 0.000 0 0
Protein localization R-HSA-9609507 9.998508e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998518e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998593e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998775e-01 0.000 1 1
Nucleotide biosynthesis R-HSA-8956320 9.998901e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998908e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999049e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999072e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999202e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999250e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999279e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999279e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999299e-01 0.000 0 0
Digestion R-HSA-8935690 9.999299e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999383e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999553e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999553e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999553e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999615e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999650e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999669e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999715e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999754e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999754e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999763e-01 0.000 0 0
Translation R-HSA-72766 9.999813e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999818e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999848e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999888e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999892e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999897e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999911e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999923e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999967e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999974e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999978e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999981e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999986e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999988e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999988e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999989e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999989e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999996e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999996e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.002687e-11 10.698 0 0
Cell Cycle, Mitotic R-HSA-69278 1.522364e-10 9.817 0 0
M Phase R-HSA-68886 3.404368e-10 9.468 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.112292e-09 8.954 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.895506e-09 8.538 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.341513e-09 8.198 0 0
Mitotic Prophase R-HSA-68875 8.176155e-09 8.087 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.540999e-08 7.812 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.888380e-08 7.724 0 0
HATs acetylate histones R-HSA-3214847 1.961896e-08 7.707 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.940018e-08 7.532 0 0
Nervous system development R-HSA-9675108 4.519915e-08 7.345 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.563955e-08 7.255 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.221977e-08 7.141 0 0
Cell Cycle Checkpoints R-HSA-69620 8.775181e-08 7.057 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.558161e-08 7.068 0 0
Chromatin modifying enzymes R-HSA-3247509 1.437093e-07 6.843 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.529403e-07 6.815 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.673976e-07 6.776 0 0
Cellular responses to stimuli R-HSA-8953897 1.698568e-07 6.770 0 0
DNA methylation R-HSA-5334118 2.070927e-07 6.684 0 0
Chromatin organization R-HSA-4839726 2.403853e-07 6.619 0 0
Axon guidance R-HSA-422475 2.341762e-07 6.630 0 0
Cell junction organization R-HSA-446728 2.648023e-07 6.577 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.577383e-07 6.589 0 0
HDACs deacetylate histones R-HSA-3214815 2.743544e-07 6.562 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.892457e-07 6.410 0 0
Cell-Cell communication R-HSA-1500931 3.958336e-07 6.402 0 0
Cellular responses to stress R-HSA-2262752 3.918763e-07 6.407 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.688568e-07 6.329 0 0
Nucleosome assembly R-HSA-774815 5.642771e-07 6.249 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.642771e-07 6.249 0 0
Signal Transduction R-HSA-162582 7.354303e-07 6.133 1 0
PRC2 methylates histones and DNA R-HSA-212300 1.072589e-06 5.970 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.214542e-06 5.916 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.214542e-06 5.916 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.212626e-06 5.916 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.271846e-06 5.896 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.316826e-06 5.880 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.493337e-06 5.826 0 0
Packaging Of Telomere Ends R-HSA-171306 1.771561e-06 5.752 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.855893e-06 5.731 0 0
Translation initiation complex formation R-HSA-72649 2.285268e-06 5.641 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.674564e-06 5.573 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.673597e-06 5.573 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.449315e-06 5.462 0 0
Metabolism of RNA R-HSA-8953854 3.861092e-06 5.413 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.868602e-06 5.412 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.023727e-06 5.299 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.023727e-06 5.299 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.392158e-06 5.268 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.392158e-06 5.268 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.286567e-06 5.277 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.298696e-06 5.201 0 0
Signaling by ALK in cancer R-HSA-9700206 6.298696e-06 5.201 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.398065e-06 5.194 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.334326e-06 5.135 0 0
Mitotic Prometaphase R-HSA-68877 7.692739e-06 5.114 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.830629e-06 5.106 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.160049e-06 5.088 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.571329e-06 5.019 0 0
Meiotic recombination R-HSA-912446 1.043598e-05 4.981 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.090922e-05 4.962 0 0
Cellular Senescence R-HSA-2559583 1.257116e-05 4.901 0 0
Defective pyroptosis R-HSA-9710421 1.276758e-05 4.894 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.304457e-05 4.885 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.380335e-05 4.860 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.489722e-05 4.827 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.510338e-05 4.821 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.550004e-05 4.810 0 0
DNA Double Strand Break Response R-HSA-5693606 1.751591e-05 4.757 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.844161e-05 4.734 0 0
G2/M Checkpoints R-HSA-69481 2.043831e-05 4.690 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.106958e-05 4.676 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.292692e-05 4.640 0 0
RNA Polymerase I Transcription R-HSA-73864 2.311009e-05 4.636 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.755337e-05 4.560 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.779325e-05 4.556 0 0
Diseases of programmed cell death R-HSA-9645723 2.813611e-05 4.551 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.995726e-05 4.523 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.022667e-05 4.520 0 0
Cell-cell junction organization R-HSA-421270 3.163274e-05 4.500 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.068593e-05 4.391 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.304613e-05 4.366 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.625667e-05 4.335 0 0
Meiotic synapsis R-HSA-1221632 5.069484e-05 4.295 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.276676e-05 4.278 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.473600e-05 4.189 0 0
Cleavage of the damaged purine R-HSA-110331 6.583772e-05 4.182 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.092055e-05 4.149 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.272581e-05 4.138 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.792989e-05 4.108 0 0
Cellular response to heat stress R-HSA-3371556 7.792989e-05 4.108 0 0
Gene Silencing by RNA R-HSA-211000 8.064387e-05 4.093 0 0
Meiosis R-HSA-1500620 8.380533e-05 4.077 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.550672e-05 4.068 0 0
Depurination R-HSA-73927 8.594269e-05 4.066 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.275759e-05 4.033 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.805385e-05 4.009 0 0
Depyrimidination R-HSA-73928 9.805385e-05 4.009 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.944570e-05 4.002 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.944570e-05 4.002 0 0
Separation of Sister Chromatids R-HSA-2467813 1.015301e-04 3.993 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.085158e-04 3.965 0 0
Mitotic Anaphase R-HSA-68882 1.151791e-04 3.939 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.251211e-04 3.903 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.273460e-04 3.895 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.333849e-04 3.875 0 0
Adherens junctions interactions R-HSA-418990 1.406698e-04 3.852 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.499540e-04 3.824 0 0
ESR-mediated signaling R-HSA-8939211 1.531797e-04 3.815 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.541508e-04 3.812 0 0
Apoptosis R-HSA-109581 1.571625e-04 3.804 0 0
Peptide chain elongation R-HSA-156902 1.632195e-04 3.787 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.637432e-04 3.786 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.637432e-04 3.786 0 0
Signaling by ROBO receptors R-HSA-376176 1.713050e-04 3.766 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.920913e-04 3.716 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.158570e-04 3.666 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.174844e-04 3.663 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.197832e-04 3.658 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.369008e-04 3.625 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.407935e-04 3.618 0 0
Interleukin-12 signaling R-HSA-9020591 2.526832e-04 3.597 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.693589e-04 3.570 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.894818e-04 3.538 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.039987e-04 3.517 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.200517e-04 3.495 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.791619e-04 3.421 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.136569e-04 3.289 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.369231e-04 3.270 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.369231e-04 3.270 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.423157e-04 3.266 0 0
Ub-specific processing proteases R-HSA-5689880 5.680367e-04 3.246 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.801451e-04 3.236 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.801451e-04 3.236 0 0
Reproduction R-HSA-1474165 6.484715e-04 3.188 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.256639e-04 3.204 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.570134e-04 3.182 0 0
Selenocysteine synthesis R-HSA-2408557 6.619822e-04 3.179 0 0
Apoptotic execution phase R-HSA-75153 6.761150e-04 3.170 0 0
HSF1-dependent transactivation R-HSA-3371571 6.821606e-04 3.166 0 0
Interleukin-12 family signaling R-HSA-447115 7.149358e-04 3.146 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.634057e-04 3.117 0 0
Muscle contraction R-HSA-397014 7.835613e-04 3.106 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.278484e-04 3.082 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.278484e-04 3.082 0 0
Activation of BH3-only proteins R-HSA-114452 8.355708e-04 3.078 0 0
Metalloprotease DUBs R-HSA-5689901 9.487348e-04 3.023 0 0
rRNA processing R-HSA-72312 8.786490e-04 3.056 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.373650e-04 3.028 0 0
Homology Directed Repair R-HSA-5693538 9.577503e-04 3.019 0 0
Influenza Infection R-HSA-168255 1.015294e-03 2.993 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.146494e-03 2.941 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.179405e-03 2.928 0 0
Attenuation phase R-HSA-3371568 1.189072e-03 2.925 0 0
RMTs methylate histone arginines R-HSA-3214858 1.206318e-03 2.919 0 0
Deubiquitination R-HSA-5688426 1.218221e-03 2.914 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.324580e-03 2.878 0 0
Signaling by VEGF R-HSA-194138 1.228568e-03 2.911 0 0
DNA Repair R-HSA-73894 1.342713e-03 2.872 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.315571e-03 2.881 0 0
Eukaryotic Translation Termination R-HSA-72764 1.308801e-03 2.883 0 0
Amyloid fiber formation R-HSA-977225 1.254895e-03 2.901 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.388668e-03 2.857 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.452747e-03 2.838 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.452747e-03 2.838 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.498332e-03 2.824 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.646664e-03 2.783 0 0
Ribosome-associated quality control R-HSA-9948299 1.715896e-03 2.766 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.749462e-03 2.757 0 0
Signaling by RAS mutants R-HSA-6802949 1.756079e-03 2.755 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.756079e-03 2.755 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.756079e-03 2.755 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.756079e-03 2.755 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.790073e-03 2.747 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.827961e-03 2.738 0 0
Striated Muscle Contraction R-HSA-390522 2.093603e-03 2.679 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.213984e-03 2.655 0 0
Cellular response to starvation R-HSA-9711097 2.252957e-03 2.647 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.262144e-03 2.645 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.262144e-03 2.645 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.138690e-03 2.670 0 0
Co-inhibition by PD-1 R-HSA-389948 2.164484e-03 2.665 0 0
Programmed Cell Death R-HSA-5357801 2.113959e-03 2.675 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.535919e-03 2.596 0 0
Chromosome Maintenance R-HSA-73886 2.564234e-03 2.591 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.681614e-03 2.572 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.742244e-03 2.562 0 0
L1CAM interactions R-HSA-373760 2.833502e-03 2.548 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.927554e-03 2.533 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.981220e-03 2.526 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.093676e-03 2.510 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.098387e-03 2.509 0 0
Signalling to ERKs R-HSA-187687 3.152743e-03 2.501 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.239260e-03 2.490 1 0
EPH-Ephrin signaling R-HSA-2682334 3.278202e-03 2.484 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.296007e-03 2.482 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.741416e-03 2.427 0 0
Viral mRNA Translation R-HSA-192823 3.415573e-03 2.467 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.646503e-03 2.438 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.675872e-03 2.435 0 0
FLT3 Signaling R-HSA-9607240 3.764315e-03 2.424 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.810377e-03 2.419 0 0
HSF1 activation R-HSA-3371511 3.826332e-03 2.417 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.991506e-03 2.399 0 0
Signaling by NOTCH R-HSA-157118 4.298262e-03 2.367 0 0
DNA Replication R-HSA-69306 4.357809e-03 2.361 0 0
MAP2K and MAPK activation R-HSA-5674135 4.488583e-03 2.348 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.654889e-03 2.332 0 0
Developmental Biology R-HSA-1266738 4.668096e-03 2.331 0 0
Recycling pathway of L1 R-HSA-437239 5.069908e-03 2.295 0 0
mRNA Splicing R-HSA-72172 5.256152e-03 2.279 0 0
CREB phosphorylation R-HSA-199920 6.090327e-03 2.215 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.477601e-03 2.261 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.642645e-03 2.249 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.465361e-03 2.262 0 0
G2/M Transition R-HSA-69275 5.345025e-03 2.272 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.660001e-03 2.247 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.815381e-03 2.235 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.227056e-03 2.206 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.601383e-03 2.180 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.651273e-03 2.177 0 0
Nuclear import of Rev protein R-HSA-180746 6.789822e-03 2.168 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.789822e-03 2.168 0 0
Kinesins R-HSA-983189 6.872466e-03 2.163 0 0
HCMV Early Events R-HSA-9609690 6.993508e-03 2.155 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.567435e-03 2.121 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.567435e-03 2.121 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.567435e-03 2.121 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.676084e-03 2.115 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.113241e-03 2.091 0 0
Signaling by NTRKs R-HSA-166520 8.241177e-03 2.084 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.425163e-03 2.074 0 0
Signaling by EGFR R-HSA-177929 8.545534e-03 2.068 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.545534e-03 2.068 0 0
Regulation of KIT signaling R-HSA-1433559 8.591873e-03 2.066 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.743767e-03 2.058 0 0
Base Excision Repair R-HSA-73884 8.807505e-03 2.055 0 0
Interleukin-2 signaling R-HSA-9020558 9.352461e-03 2.029 0 0
Regulation of CDH1 Function R-HSA-9764561 9.780778e-03 2.010 0 0
Signaling by Interleukins R-HSA-449147 9.806629e-03 2.008 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.957157e-03 2.002 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.016666e-02 1.993 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.038302e-02 1.984 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.194109e-02 1.923 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.135861e-02 1.945 0 0
Telomere Maintenance R-HSA-157579 1.194277e-02 1.923 0 0
UCH proteinases R-HSA-5689603 1.197126e-02 1.922 0 0
Rap1 signalling R-HSA-392517 1.223401e-02 1.912 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.135861e-02 1.945 0 0
Cellular response to chemical stress R-HSA-9711123 1.110349e-02 1.955 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.194109e-02 1.923 0 0
Smooth Muscle Contraction R-HSA-445355 1.218422e-02 1.914 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.275716e-02 1.894 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.389783e-02 1.857 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.454941e-02 1.837 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.460283e-02 1.836 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.524252e-02 1.817 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.552158e-02 1.809 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.552158e-02 1.809 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.656245e-02 1.781 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.694779e-02 1.771 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.694779e-02 1.771 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.761027e-02 1.754 0 0
NRAGE signals death through JNK R-HSA-193648 1.788011e-02 1.748 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.799245e-02 1.745 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.799245e-02 1.745 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.799245e-02 1.745 0 0
Signaling by MET R-HSA-6806834 1.838186e-02 1.736 0 0
Signalling to RAS R-HSA-167044 1.875361e-02 1.727 0 0
Signaling by WNT R-HSA-195721 1.888299e-02 1.724 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.896007e-02 1.722 0 0
ALK mutants bind TKIs R-HSA-9700645 1.896007e-02 1.722 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.896007e-02 1.722 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.941563e-02 1.712 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.948244e-02 1.710 0 0
MAPK family signaling cascades R-HSA-5683057 1.955037e-02 1.709 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.074688e-02 1.683 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.077780e-02 1.682 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.077780e-02 1.682 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.199960e-02 1.658 0 0
RET signaling R-HSA-8853659 2.254602e-02 1.647 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.280734e-02 1.642 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.678380e-02 1.572 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.678380e-02 1.572 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.678380e-02 1.572 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.678380e-02 1.572 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.603116e-02 1.585 0 0
Integrin signaling R-HSA-354192 2.832464e-02 1.548 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.832464e-02 1.548 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.789362e-02 1.554 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.797875e-02 1.553 0 0
Nef and signal transduction R-HSA-164944 2.811217e-02 1.551 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.832464e-02 1.548 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.406022e-02 1.619 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.602970e-02 1.585 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.418277e-02 1.616 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.535974e-02 1.596 0 0
Selenoamino acid metabolism R-HSA-2408522 2.660132e-02 1.575 0 0
Signaling by ERBB2 R-HSA-1227986 2.838878e-02 1.547 1 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.988826e-02 1.524 0 0
Signaling by SCF-KIT R-HSA-1433557 3.088483e-02 1.510 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.091033e-02 1.510 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.095336e-02 1.509 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.275034e-02 1.485 0 0
Death Receptor Signaling R-HSA-73887 3.292738e-02 1.482 0 0
PECAM1 interactions R-HSA-210990 3.355531e-02 1.474 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.360451e-02 1.474 0 0
Regulation of signaling by CBL R-HSA-912631 3.431366e-02 1.465 0 0
Erythropoietin activates RAS R-HSA-9027284 3.494085e-02 1.457 0 0
p38MAPK events R-HSA-171007 3.494085e-02 1.457 0 0
Ion homeostasis R-HSA-5578775 3.532912e-02 1.452 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.569330e-02 1.447 0 0
RAF activation R-HSA-5673000 3.763922e-02 1.424 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.858211e-02 1.414 0 0
Signaling by PTK6 R-HSA-8848021 3.884732e-02 1.411 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.884732e-02 1.411 0 0
Semaphorin interactions R-HSA-373755 3.884732e-02 1.411 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.892399e-02 1.410 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.892399e-02 1.410 0 0
SOS-mediated signalling R-HSA-112412 3.892399e-02 1.410 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.892399e-02 1.410 0 0
HCMV Late Events R-HSA-9610379 3.978885e-02 1.400 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.996003e-02 1.398 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.107683e-02 1.386 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.107683e-02 1.386 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.107683e-02 1.386 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.107683e-02 1.386 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.115957e-02 1.386 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.134266e-02 1.384 1 1
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.223871e-02 1.374 0 0
Selective autophagy R-HSA-9663891 4.223871e-02 1.374 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.388167e-02 1.358 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.416991e-02 1.355 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.416991e-02 1.355 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.514578e-02 1.345 0 0
Interleukin-7 signaling R-HSA-1266695 4.514578e-02 1.345 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.741692e-02 1.324 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.821956e-02 1.317 0 0
Host Interactions of HIV factors R-HSA-162909 4.851692e-02 1.314 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.883566e-02 1.311 0 0
G alpha (12/13) signalling events R-HSA-416482 4.894639e-02 1.310 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.554552e-02 1.255 0 0
Oligomerization of connexins into connexons R-HSA-190704 5.554552e-02 1.255 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 5.554552e-02 1.255 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.554552e-02 1.255 0 0
Transport of connexins along the secretory pathway R-HSA-190827 5.554552e-02 1.255 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.554552e-02 1.255 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.179684e-02 1.286 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.179684e-02 1.286 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.365630e-02 1.270 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.210301e-02 1.207 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.036690e-02 1.219 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.181645e-02 1.286 0 0
Interleukin-15 signaling R-HSA-8983432 5.365630e-02 1.270 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.365630e-02 1.270 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.960856e-02 1.225 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.179684e-02 1.286 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.179854e-02 1.209 0 0
MTOR signalling R-HSA-165159 5.538066e-02 1.257 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.002724e-02 1.222 0 0
Signaling by LTK R-HSA-9842663 5.365630e-02 1.270 0 0
Signaling by Hippo R-HSA-2028269 6.210301e-02 1.207 0 0
Specification of primordial germ cells R-HSA-9827857 6.210301e-02 1.207 0 0
PKR-mediated signaling R-HSA-9833482 5.788126e-02 1.237 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.217094e-02 1.206 0 0
Protein folding R-HSA-391251 6.257565e-02 1.204 0 0
Adaptive Immune System R-HSA-1280218 6.291126e-02 1.201 0 0
tRNA processing in the nucleus R-HSA-6784531 6.392478e-02 1.194 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.513337e-02 1.186 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.519733e-02 1.186 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.575677e-02 1.182 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.584021e-02 1.182 0 0
ARMS-mediated activation R-HSA-170984 6.671124e-02 1.176 0 0
Signaling by KIT in disease R-HSA-9669938 6.675700e-02 1.176 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.675700e-02 1.176 0 0
mTORC1-mediated signalling R-HSA-166208 6.675700e-02 1.176 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.739197e-02 1.171 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.961336e-02 1.157 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.983208e-02 1.156 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.983208e-02 1.156 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.983208e-02 1.156 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.983208e-02 1.156 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.986551e-02 1.156 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.986551e-02 1.156 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.986551e-02 1.156 0 0
Membrane Trafficking R-HSA-199991 7.074915e-02 1.150 0 0
Nucleotide Excision Repair R-HSA-5696398 7.081594e-02 1.150 0 0
Polo-like kinase mediated events R-HSA-156711 7.331246e-02 1.135 0 0
Ephrin signaling R-HSA-3928664 7.331246e-02 1.135 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.331246e-02 1.135 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.611318e-02 1.119 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.611318e-02 1.119 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.702214e-02 1.113 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.702214e-02 1.113 0 0
S Phase R-HSA-69242 7.718989e-02 1.112 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.759663e-02 1.110 0 0
Interleukin-2 family signaling R-HSA-451927 7.759663e-02 1.110 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.109999e-02 1.040 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.109999e-02 1.040 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.109999e-02 1.040 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.109999e-02 1.040 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.136702e-02 1.090 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 8.136702e-02 1.090 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.360261e-02 1.078 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.360261e-02 1.078 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.023684e-01 0.990 0 0
DCC mediated attractive signaling R-HSA-418885 9.441389e-02 1.025 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.441389e-02 1.025 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.441389e-02 1.025 0 0
Deadenylation of mRNA R-HSA-429947 8.815720e-02 1.055 0 0
Tight junction interactions R-HSA-420029 1.001528e-01 0.999 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.848683e-02 1.105 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.848683e-02 1.105 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.152777e-02 1.089 0 0
snRNP Assembly R-HSA-191859 8.604535e-02 1.065 0 0
Metabolism of non-coding RNA R-HSA-194441 8.604535e-02 1.065 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.296736e-02 1.032 0 0
Signaling by NOTCH4 R-HSA-9013694 1.001573e-01 0.999 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.898950e-02 1.102 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.559999e-02 1.068 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.776541e-02 1.057 0 0
Co-stimulation by CD28 R-HSA-389356 1.011685e-01 0.995 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.001573e-01 0.999 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.924483e-02 1.049 0 0
Signal attenuation R-HSA-74749 8.360261e-02 1.078 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.001528e-01 0.999 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.001528e-01 0.999 0 0
Post NMDA receptor activation events R-HSA-438064 1.046099e-01 0.980 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.611015e-02 1.065 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.846465e-02 1.105 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.766662e-02 1.010 0 0
Signal transduction by L1 R-HSA-445144 9.894778e-02 1.005 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.944559e-02 1.048 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.360261e-02 1.078 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.519757e-02 1.021 0 0
Pexophagy R-HSA-9664873 8.360261e-02 1.078 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.611015e-02 1.065 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.612443e-02 1.065 0 0
TRAIL signaling R-HSA-75158 8.136702e-02 1.090 0 0
TGFBR3 expression R-HSA-9839394 1.001528e-01 0.999 0 0
Signaling by Leptin R-HSA-2586552 8.360261e-02 1.078 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.946759e-02 1.002 0 0
Interleukin-37 signaling R-HSA-9008059 8.860448e-02 1.053 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.360261e-02 1.078 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.612443e-02 1.065 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.136702e-02 1.090 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.109455e-02 1.041 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.060151e-01 0.975 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.060151e-01 0.975 0 0
Centrosome maturation R-HSA-380287 1.076802e-01 0.968 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.080315e-01 0.966 1 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.081855e-01 0.966 0 0
Interferon Signaling R-HSA-913531 1.102091e-01 0.958 0 0
Prolonged ERK activation events R-HSA-169893 1.107186e-01 0.956 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.107186e-01 0.956 0 0
Viral Infection Pathways R-HSA-9824446 1.121337e-01 0.950 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.150021e-01 0.939 0 0
Autophagy R-HSA-9612973 1.159925e-01 0.936 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.181708e-01 0.927 0 0
KIT mutants bind TKIs R-HSA-9669921 1.181708e-01 0.927 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.181708e-01 0.927 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.181708e-01 0.927 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.181708e-01 0.927 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.181708e-01 0.927 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.181708e-01 0.927 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.181708e-01 0.927 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.181708e-01 0.927 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.181708e-01 0.927 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.228757e-01 0.911 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.228757e-01 0.911 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.233208e-01 0.909 0 0
Gap junction trafficking R-HSA-190828 1.256543e-01 0.901 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.256543e-01 0.901 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.266522e-01 0.897 0 0
Ion transport by P-type ATPases R-HSA-936837 1.277178e-01 0.894 0 0
Disorders of Developmental Biology R-HSA-9675151 1.282830e-01 0.892 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.282830e-01 0.892 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.286984e-01 0.890 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.286984e-01 0.890 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.286984e-01 0.890 0 0
Circadian clock R-HSA-9909396 1.291292e-01 0.889 0 0
HCMV Infection R-HSA-9609646 1.298752e-01 0.886 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.310377e-01 0.883 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.314417e-01 0.881 0 0
MET interacts with TNS proteins R-HSA-8875513 1.314417e-01 0.881 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.314417e-01 0.881 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.314417e-01 0.881 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.314417e-01 0.881 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.314417e-01 0.881 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.314417e-01 0.881 0 0
FasL/ CD95L signaling R-HSA-75157 1.314417e-01 0.881 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.331696e-01 0.876 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.331696e-01 0.876 0 0
PTK6 Expression R-HSA-8849473 1.331696e-01 0.876 0 0
CHL1 interactions R-HSA-447041 1.331696e-01 0.876 0 0
Dual incision in TC-NER R-HSA-6782135 1.343176e-01 0.872 0 0
DAG and IP3 signaling R-HSA-1489509 1.368599e-01 0.864 1 1
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.749440e-01 0.757 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.749440e-01 0.757 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.749440e-01 0.757 0 0
Type I hemidesmosome assembly R-HSA-446107 1.624263e-01 0.789 0 0
Formation of annular gap junctions R-HSA-196025 1.624263e-01 0.789 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.449678e-01 0.839 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.933786e-01 0.714 0 0
Lipophagy R-HSA-9613354 1.933786e-01 0.714 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.933786e-01 0.714 0 0
Gap junction degradation R-HSA-190873 1.933786e-01 0.714 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.933786e-01 0.714 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.933786e-01 0.714 0 0
CASP8 activity is inhibited R-HSA-5218900 1.933786e-01 0.714 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 1.684714e-01 0.773 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.470250e-01 0.833 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.668511e-01 0.778 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.876585e-01 0.727 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.622170e-01 0.790 0 0
Signaling by Erythropoietin R-HSA-9006335 1.563069e-01 0.806 0 0
Late endosomal microautophagy R-HSA-9615710 1.563069e-01 0.806 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.802448e-01 0.744 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.093381e-01 0.679 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.093381e-01 0.679 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.093381e-01 0.679 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.093381e-01 0.679 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.093381e-01 0.679 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.093381e-01 0.679 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.093381e-01 0.679 0 0
Dual Incision in GG-NER R-HSA-5696400 1.498903e-01 0.824 0 0
DAP12 signaling R-HSA-2424491 1.722247e-01 0.764 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.722247e-01 0.764 0 0
Long-term potentiation R-HSA-9620244 1.990282e-01 0.701 0 0
Aggrephagy R-HSA-9646399 1.433431e-01 0.844 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.562104e-01 0.806 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.607772e-01 0.794 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.524451e-01 0.817 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.885355e-01 0.725 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.892735e-01 0.723 0 0
Neutrophil degranulation R-HSA-6798695 1.995745e-01 0.700 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.017993e-01 0.695 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.017993e-01 0.695 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.696175e-01 0.771 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.722247e-01 0.764 0 0
Gap junction trafficking and regulation R-HSA-157858 1.865868e-01 0.729 0 0
Signaling by FGFR1 R-HSA-5654736 1.885355e-01 0.725 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.470250e-01 0.833 0 0
IGF1R signaling cascade R-HSA-2428924 2.018543e-01 0.695 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.684714e-01 0.773 0 0
Gap junction assembly R-HSA-190861 1.498903e-01 0.824 0 0
Degradation of DVL R-HSA-4641258 1.943728e-01 0.711 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.060128e-01 0.686 0 0
HDMs demethylate histones R-HSA-3214842 1.990282e-01 0.701 0 0
MET activates RAS signaling R-HSA-8851805 1.449678e-01 0.839 0 0
Interleukin-6 signaling R-HSA-1059683 1.684714e-01 0.773 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.932021e-01 0.714 0 0
GPVI-mediated activation cascade R-HSA-114604 1.789712e-01 0.747 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.438555e-01 0.842 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.438555e-01 0.842 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.600637e-01 0.796 0 0
G-protein mediated events R-HSA-112040 1.573388e-01 0.803 0 0
Developmental Cell Lineages R-HSA-9734767 2.005638e-01 0.698 0 0
Mismatch Repair R-HSA-5358508 1.668511e-01 0.778 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.449678e-01 0.839 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.668511e-01 0.778 0 0
PLC beta mediated events R-HSA-112043 1.663720e-01 0.779 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.518390e-01 0.819 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.518390e-01 0.819 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.518390e-01 0.819 0 0
Frs2-mediated activation R-HSA-170968 1.684714e-01 0.773 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.449678e-01 0.839 0 0
Platelet sensitization by LDL R-HSA-432142 1.668511e-01 0.778 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.668511e-01 0.778 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.876585e-01 0.727 0 0
Negative regulation of MET activity R-HSA-6807004 2.093381e-01 0.679 0 0
Ca-dependent events R-HSA-111996 1.835395e-01 0.736 0 0
Macroautophagy R-HSA-1632852 1.484594e-01 0.828 0 0
MAP kinase activation R-HSA-450294 1.663720e-01 0.779 0 0
TCR signaling R-HSA-202403 2.047114e-01 0.689 0 0
Calmodulin induced events R-HSA-111933 1.789712e-01 0.747 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.901856e-01 0.721 0 0
CaM pathway R-HSA-111997 1.789712e-01 0.747 0 0
The NLRP3 inflammasome R-HSA-844456 1.876585e-01 0.727 0 0
Signaling by FGFR4 R-HSA-5654743 1.979491e-01 0.703 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.438275e-01 0.842 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.762258e-01 0.754 0 0
Signaling by TGFB family members R-HSA-9006936 1.883647e-01 0.725 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.624263e-01 0.789 0 0
Gene expression (Transcription) R-HSA-74160 1.516320e-01 0.819 0 0
MTF1 activates gene expression R-HSA-5660489 1.749440e-01 0.757 0 0
Dopamine receptors R-HSA-390651 1.749440e-01 0.757 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.749440e-01 0.757 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.624263e-01 0.789 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.933786e-01 0.714 0 0
FLT3 signaling in disease R-HSA-9682385 1.789712e-01 0.747 0 0
RNA Polymerase II Transcription R-HSA-73857 1.962446e-01 0.707 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.449678e-01 0.839 0 0
Regulation of TP53 Activity R-HSA-5633007 1.883647e-01 0.725 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.937231e-01 0.713 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.684714e-01 0.773 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.789712e-01 0.747 0 0
Glycolysis R-HSA-70171 1.691159e-01 0.772 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.449678e-01 0.839 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.449678e-01 0.839 0 0
Neurodegenerative Diseases R-HSA-8863678 1.802448e-01 0.744 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.802448e-01 0.744 0 0
FOXO-mediated transcription R-HSA-9614085 1.603520e-01 0.795 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.624263e-01 0.789 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.682528e-01 0.774 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.885355e-01 0.725 0 0
SARS-CoV Infections R-HSA-9679506 1.395647e-01 0.855 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.696175e-01 0.771 0 0
MET promotes cell motility R-HSA-8875878 2.102990e-01 0.677 0 0
Translation R-HSA-72766 2.104185e-01 0.677 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.128164e-01 0.672 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.223833e-01 0.653 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.223833e-01 0.653 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.223833e-01 0.653 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.223833e-01 0.653 0 0
Defective GALM causes GALAC4 R-HSA-9931929 2.223833e-01 0.653 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.223833e-01 0.653 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.223833e-01 0.653 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.223833e-01 0.653 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.223833e-01 0.653 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.223833e-01 0.653 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.223833e-01 0.653 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.223833e-01 0.653 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.223833e-01 0.653 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.223833e-01 0.653 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.142856e-01 0.503 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.142856e-01 0.503 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.142856e-01 0.503 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.142856e-01 0.503 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.142856e-01 0.503 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.142856e-01 0.503 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.142856e-01 0.503 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.142856e-01 0.503 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.142856e-01 0.503 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.142856e-01 0.503 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.142856e-01 0.503 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.142856e-01 0.503 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.142856e-01 0.503 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.142856e-01 0.503 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.142856e-01 0.503 0 0
IRS activation R-HSA-74713 2.202974e-01 0.657 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.202974e-01 0.657 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.202974e-01 0.657 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.202974e-01 0.657 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.202974e-01 0.657 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.202974e-01 0.657 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 2.664577e-01 0.574 0 0
Phosphorylation of Emi1 R-HSA-176417 2.664577e-01 0.574 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.664577e-01 0.574 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.664577e-01 0.574 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.953312e-01 0.403 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.953312e-01 0.403 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.953312e-01 0.403 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.953312e-01 0.403 0 0
Defective DHDDS causes RP59 R-HSA-4755609 3.953312e-01 0.403 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.953312e-01 0.403 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.953312e-01 0.403 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.953312e-01 0.403 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.953312e-01 0.403 0 0
Potassium transport channels R-HSA-1296067 3.953312e-01 0.403 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.953312e-01 0.403 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.953312e-01 0.403 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.953312e-01 0.403 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.256312e-01 0.647 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.256312e-01 0.647 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.256312e-01 0.647 0 0
STAT5 Activation R-HSA-9645135 3.126011e-01 0.505 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.126011e-01 0.505 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.126011e-01 0.505 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.126011e-01 0.505 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.126011e-01 0.505 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.588096e-01 0.587 0 0
Signaling by APC mutants R-HSA-4839744 2.588096e-01 0.587 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.588096e-01 0.587 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.588096e-01 0.587 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.588096e-01 0.587 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.189698e-01 0.660 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.189698e-01 0.660 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.455831e-01 0.610 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.925666e-01 0.534 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.925666e-01 0.534 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.925666e-01 0.534 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.925666e-01 0.534 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.580874e-01 0.446 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.580874e-01 0.446 0 0
Netrin mediated repulsion signals R-HSA-418886 3.580874e-01 0.446 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.580874e-01 0.446 0 0
Disinhibition of SNARE formation R-HSA-114516 3.580874e-01 0.446 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.317762e-01 0.635 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.728535e-01 0.564 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.728535e-01 0.564 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.728535e-01 0.564 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.265860e-01 0.486 0 0
Pervasive developmental disorders R-HSA-9005895 3.265860e-01 0.486 0 0
Disorders of Nervous System Development R-HSA-9697154 3.265860e-01 0.486 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.265860e-01 0.486 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.265860e-01 0.486 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.265860e-01 0.486 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.265860e-01 0.486 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.265860e-01 0.486 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.548566e-01 0.594 0 0
Regulation by c-FLIP R-HSA-3371378 4.024276e-01 0.395 0 0
Dimerization of procaspase-8 R-HSA-69416 4.024276e-01 0.395 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.024276e-01 0.395 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.024276e-01 0.395 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.237801e-01 0.650 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.605847e-01 0.443 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.024787e-01 0.519 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.435617e-01 0.613 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.284718e-01 0.641 0 0
mRNA 3'-end processing R-HSA-72187 2.284718e-01 0.641 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.016162e-01 0.521 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.267916e-01 0.486 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.568197e-01 0.448 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.233108e-01 0.490 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.512919e-01 0.454 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.512919e-01 0.454 0 0
Formation of definitive endoderm R-HSA-9823730 3.849795e-01 0.415 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.735400e-01 0.563 0 0
Degradation of CDH1 R-HSA-9766229 2.928525e-01 0.533 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.674519e-01 0.573 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.852841e-01 0.545 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.672434e-01 0.435 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.129802e-01 0.384 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.908716e-01 0.536 0 0
Orc1 removal from chromatin R-HSA-68949 3.441290e-01 0.463 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.044981e-01 0.516 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.792858e-01 0.421 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.792858e-01 0.421 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.792858e-01 0.421 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.700745e-01 0.432 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.615378e-01 0.442 0 0
HIV elongation arrest and recovery R-HSA-167287 4.248984e-01 0.372 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.248984e-01 0.372 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.248984e-01 0.372 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.114026e-01 0.386 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.888121e-01 0.410 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.818832e-01 0.550 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.799021e-01 0.553 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.672434e-01 0.435 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.248984e-01 0.372 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.237801e-01 0.650 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.758749e-01 0.425 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.268532e-01 0.486 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.995109e-01 0.398 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.184940e-01 0.661 0 0
DNA Damage Bypass R-HSA-73893 2.928525e-01 0.533 0 0
Insulin receptor signalling cascade R-HSA-74751 4.197501e-01 0.377 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.700745e-01 0.432 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.202974e-01 0.657 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.286415e-01 0.483 0 0
TRP channels R-HSA-3295583 3.758749e-01 0.425 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.865595e-01 0.413 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.267916e-01 0.486 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.769267e-01 0.424 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.202974e-01 0.657 0 0
Regulation of CDH11 function R-HSA-9762292 2.256312e-01 0.647 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.588096e-01 0.587 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.189698e-01 0.660 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.580874e-01 0.446 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.548566e-01 0.594 0 0
Processing of SMDT1 R-HSA-8949664 3.605847e-01 0.443 0 0
Regulation of Apoptosis R-HSA-169911 2.799021e-01 0.553 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.259416e-01 0.646 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.452121e-01 0.462 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.143756e-01 0.669 0 0
HIV Life Cycle R-HSA-162587 2.879713e-01 0.541 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.588096e-01 0.587 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.004414e-01 0.397 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.114026e-01 0.386 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.548566e-01 0.594 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.615378e-01 0.442 0 0
Netrin-1 signaling R-HSA-373752 3.328668e-01 0.478 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.737569e-01 0.563 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.664577e-01 0.574 0 0
Activation of RAC1 R-HSA-428540 2.925666e-01 0.534 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.728535e-01 0.564 0 0
Regulation of IFNG signaling R-HSA-877312 3.265860e-01 0.486 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.243837e-01 0.649 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.248984e-01 0.372 0 0
TNF signaling R-HSA-75893 4.141922e-01 0.383 0 0
Mitophagy R-HSA-5205647 2.607831e-01 0.584 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.929870e-01 0.406 0 0
HIV Infection R-HSA-162906 2.611438e-01 0.583 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.879771e-01 0.541 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.094222e-01 0.388 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.386880e-01 0.470 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.094222e-01 0.388 0 0
Integration of provirus R-HSA-162592 2.925666e-01 0.534 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.792858e-01 0.421 0 0
Diseases of Immune System R-HSA-5260271 3.792858e-01 0.421 0 0
Interleukin-9 signaling R-HSA-8985947 4.024276e-01 0.395 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.616192e-01 0.442 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.691217e-01 0.570 0 0
Opioid Signalling R-HSA-111885 3.767419e-01 0.424 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.664577e-01 0.574 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.256312e-01 0.647 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.126011e-01 0.505 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.925666e-01 0.534 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.580874e-01 0.446 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.582294e-01 0.588 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.114026e-01 0.386 0 0
Cilium Assembly R-HSA-5617833 3.939486e-01 0.405 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.034865e-01 0.394 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.728535e-01 0.564 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.568197e-01 0.448 0 0
Glycogen synthesis R-HSA-3322077 3.849795e-01 0.415 0 0
Signaling by FGFR R-HSA-190236 3.984425e-01 0.400 0 0
Signaling by FGFR2 R-HSA-5654738 3.182934e-01 0.497 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.650589e-01 0.577 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.605847e-01 0.443 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.087437e-01 0.389 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.404890e-01 0.468 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.142211e-01 0.503 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.758749e-01 0.425 0 0
Cardiac conduction R-HSA-5576891 3.084255e-01 0.511 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.208348e-01 0.494 1 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 2.588096e-01 0.587 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.849795e-01 0.415 0 0
Heme signaling R-HSA-9707616 2.705876e-01 0.568 0 0
Interleukin-17 signaling R-HSA-448424 2.813682e-01 0.551 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.865595e-01 0.413 0 0
Hedgehog 'on' state R-HSA-5632684 2.955007e-01 0.529 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.619690e-01 0.582 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.758749e-01 0.425 0 0
Integration of energy metabolism R-HSA-163685 3.734213e-01 0.428 0 0
Signaling by FGFR3 R-HSA-5654741 2.281097e-01 0.642 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.929870e-01 0.406 0 0
Neurofascin interactions R-HSA-447043 3.126011e-01 0.505 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.591007e-01 0.445 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.993343e-01 0.524 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.265860e-01 0.486 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.005978e-01 0.522 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.893305e-01 0.410 1 1
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.024787e-01 0.519 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.455831e-01 0.610 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.437955e-01 0.613 0 0
DAP12 interactions R-HSA-2172127 3.328668e-01 0.478 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.196607e-01 0.658 0 0
Immune System R-HSA-168256 3.543476e-01 0.451 1 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.137230e-01 0.670 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.281212e-01 0.484 0 0
Hemostasis R-HSA-109582 2.918041e-01 0.535 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.223833e-01 0.653 0 0
SDK interactions R-HSA-373756 2.223833e-01 0.653 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.142856e-01 0.503 0 0
Mitochondrial transcription initiation R-HSA-163282 3.142856e-01 0.503 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.664577e-01 0.574 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.953312e-01 0.403 0 0
C6 deamination of adenosine R-HSA-75102 3.953312e-01 0.403 0 0
Signalling to ERK5 R-HSA-198765 3.953312e-01 0.403 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.925666e-01 0.534 0 0
Signaling by AXIN mutants R-HSA-4839735 2.925666e-01 0.534 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.580874e-01 0.446 0 0
Regulation of PTEN localization R-HSA-8948747 3.580874e-01 0.446 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.548566e-01 0.594 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 3.605847e-01 0.443 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.605847e-01 0.443 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.286415e-01 0.483 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.002061e-01 0.523 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.248984e-01 0.372 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.114026e-01 0.386 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.700212e-01 0.432 0 0
Rab regulation of trafficking R-HSA-9007101 2.214932e-01 0.655 0 0
G1/S Transition R-HSA-69206 2.377235e-01 0.624 0 0
Generic Transcription Pathway R-HSA-212436 3.056253e-01 0.515 0 0
Generation of second messenger molecules R-HSA-202433 2.435617e-01 0.613 0 0
Stabilization of p53 R-HSA-69541 3.591007e-01 0.445 0 0
NGF-stimulated transcription R-HSA-9031628 2.762034e-01 0.559 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.865595e-01 0.413 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.265860e-01 0.486 0 0
Signaling by ALK R-HSA-201556 2.267095e-01 0.645 0 0
Formation of the ureteric bud R-HSA-9830674 3.024787e-01 0.519 0 0
Malate-aspartate shuttle R-HSA-9856872 3.943131e-01 0.404 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.537735e-01 0.596 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.784627e-01 0.555 0 0
Ion channel transport R-HSA-983712 3.133971e-01 0.504 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.672434e-01 0.435 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.263341e-01 0.370 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.263341e-01 0.370 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.664577e-01 0.574 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.891000e-01 0.410 0 0
Inflammasomes R-HSA-622312 4.248984e-01 0.372 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.317762e-01 0.635 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.317762e-01 0.635 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.005978e-01 0.522 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.005978e-01 0.522 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.385653e-01 0.622 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.758749e-01 0.425 0 0
Downstream signal transduction R-HSA-186763 3.233108e-01 0.490 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.758749e-01 0.425 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.661493e-01 0.436 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.202974e-01 0.657 0 0
Transcription from mitochondrial promoters R-HSA-75944 3.953312e-01 0.403 0 0
DSCAM interactions R-HSA-376172 3.953312e-01 0.403 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.126011e-01 0.505 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.588096e-01 0.587 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.129802e-01 0.384 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.700212e-01 0.432 0 0
Glucose metabolism R-HSA-70326 2.975000e-01 0.527 0 0
Diseases of DNA repair R-HSA-9675135 2.437955e-01 0.613 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.548566e-01 0.594 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.267095e-01 0.645 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.995109e-01 0.398 0 0
Sensory processing of sound R-HSA-9659379 4.136120e-01 0.383 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.537401e-01 0.451 0 0
Signal regulatory protein family interactions R-HSA-391160 3.943131e-01 0.404 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.548566e-01 0.594 0 0
Tie2 Signaling R-HSA-210993 3.286415e-01 0.483 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.758749e-01 0.425 0 0
Signaling by NOTCH2 R-HSA-1980145 2.607831e-01 0.584 0 0
Signaling by NOTCH3 R-HSA-9012852 3.966058e-01 0.402 0 0
Formation of the anterior neural plate R-HSA-9823739 2.189698e-01 0.660 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.953312e-01 0.403 0 0
Sodium/Proton exchangers R-HSA-425986 4.024276e-01 0.395 0 0
Zinc transporters R-HSA-435354 3.943131e-01 0.404 0 0
MHC class II antigen presentation R-HSA-2132295 3.656131e-01 0.437 0 0
Growth hormone receptor signaling R-HSA-982772 3.024787e-01 0.519 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.664577e-01 0.574 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.664577e-01 0.574 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.004414e-01 0.397 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.286415e-01 0.483 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.275550e-01 0.369 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.275550e-01 0.369 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.275550e-01 0.369 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.275550e-01 0.369 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.275550e-01 0.369 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.275550e-01 0.369 0 0
p75NTR signals via NF-kB R-HSA-193639 4.275550e-01 0.369 0 0
Protein methylation R-HSA-8876725 4.275550e-01 0.369 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.275550e-01 0.369 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.275550e-01 0.369 0 0
IRS-mediated signalling R-HSA-112399 4.317665e-01 0.365 0 0
PERK regulates gene expression R-HSA-381042 4.333925e-01 0.363 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.333925e-01 0.363 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.398680e-01 0.357 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.398680e-01 0.357 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.406943e-01 0.356 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.406943e-01 0.356 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.452575e-01 0.351 0 0
Interleukin-21 signaling R-HSA-9020958 4.452575e-01 0.351 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.452575e-01 0.351 0 0
WNT mediated activation of DVL R-HSA-201688 4.452575e-01 0.351 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 4.452575e-01 0.351 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.452575e-01 0.351 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.452575e-01 0.351 0 0
Unwinding of DNA R-HSA-176974 4.452575e-01 0.351 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.452575e-01 0.351 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.452575e-01 0.351 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.452575e-01 0.351 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.458773e-01 0.351 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.458773e-01 0.351 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.491594e-01 0.348 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.491594e-01 0.348 0 0
Platelet calcium homeostasis R-HSA-418360 4.491594e-01 0.348 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.491594e-01 0.348 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.491594e-01 0.348 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 4.491594e-01 0.348 0 0
RUNX2 regulates bone development R-HSA-8941326 4.552366e-01 0.342 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.598993e-01 0.337 0 0
TBC/RABGAPs R-HSA-8854214 4.598993e-01 0.337 0 0
Phosphorylation of the APC/C R-HSA-176412 4.601258e-01 0.337 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.601258e-01 0.337 0 0
Killing mechanisms R-HSA-9664420 4.601258e-01 0.337 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.601258e-01 0.337 0 0
Negative regulation of FLT3 R-HSA-9706369 4.601258e-01 0.337 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.601258e-01 0.337 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.667445e-01 0.331 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.668020e-01 0.331 0 0
MET activates STAT3 R-HSA-8875791 4.668020e-01 0.331 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.668020e-01 0.331 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.668020e-01 0.331 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.668020e-01 0.331 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.668020e-01 0.331 0 0
Axonal growth stimulation R-HSA-209563 4.668020e-01 0.331 0 0
MET activates PTPN11 R-HSA-8865999 4.668020e-01 0.331 0 0
Invadopodia formation R-HSA-8941237 4.668020e-01 0.331 0 0
Signalling to STAT3 R-HSA-198745 4.668020e-01 0.331 0 0
FGFR2 alternative splicing R-HSA-6803529 4.680074e-01 0.330 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.680074e-01 0.330 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.680074e-01 0.330 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.680074e-01 0.330 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.716650e-01 0.326 0 0
Activation of the pre-replicative complex R-HSA-68962 4.731452e-01 0.325 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.731452e-01 0.325 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.731452e-01 0.325 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.731452e-01 0.325 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.731452e-01 0.325 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.768758e-01 0.322 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.797699e-01 0.319 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.821176e-01 0.317 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.840845e-01 0.315 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.840845e-01 0.315 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.840845e-01 0.315 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.840845e-01 0.315 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.840845e-01 0.315 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.840845e-01 0.315 0 0
Transcription of the HIV genome R-HSA-167172 4.857726e-01 0.314 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.863148e-01 0.313 0 0
PI3K/AKT activation R-HSA-198203 4.863148e-01 0.313 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.863148e-01 0.313 0 0
Interleukin-27 signaling R-HSA-9020956 4.863148e-01 0.313 0 0
2-LTR circle formation R-HSA-164843 4.863148e-01 0.313 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.863148e-01 0.313 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.863148e-01 0.313 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.863148e-01 0.313 0 0
Signaling by NOTCH1 R-HSA-1980143 4.872490e-01 0.312 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.918712e-01 0.308 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.918712e-01 0.308 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.918712e-01 0.308 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.918712e-01 0.308 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.918712e-01 0.308 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.918712e-01 0.308 0 0
Galactose catabolism R-HSA-70370 4.918712e-01 0.308 0 0
Inositol phosphate metabolism R-HSA-1483249 4.926924e-01 0.307 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.935320e-01 0.307 0 0
PTEN Regulation R-HSA-6807070 4.957442e-01 0.305 0 0
EGFR downregulation R-HSA-182971 4.967835e-01 0.304 0 0
Trafficking of AMPA receptors R-HSA-399719 4.967835e-01 0.304 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.968968e-01 0.304 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.982553e-01 0.303 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.982553e-01 0.303 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.994362e-01 0.302 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.994362e-01 0.302 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.012851e-01 0.300 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.059204e-01 0.296 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.181738e-01 0.286 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.185369e-01 0.285 0 0
Signaling by TGFBR3 R-HSA-9839373 5.188579e-01 0.285 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.193247e-01 0.285 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.200093e-01 0.284 0 0
Interleukin-6 family signaling R-HSA-6783589 5.210393e-01 0.283 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.210393e-01 0.283 0 0
Mitochondrial RNA degradation R-HSA-9836573 5.210393e-01 0.283 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.210393e-01 0.283 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.226646e-01 0.282 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.226646e-01 0.282 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.254203e-01 0.279 0 0
Transport of RCbl within the body R-HSA-9758890 5.254203e-01 0.279 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.254203e-01 0.279 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.254203e-01 0.279 0 0
Gastrulation R-HSA-9758941 5.295429e-01 0.276 0 0
Regulation of gap junction activity R-HSA-191650 5.298288e-01 0.276 0 0
HCN channels R-HSA-1296061 5.298288e-01 0.276 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.298288e-01 0.276 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.298288e-01 0.276 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.298288e-01 0.276 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.298288e-01 0.276 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.298288e-01 0.276 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.298288e-01 0.276 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 5.298288e-01 0.276 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.298288e-01 0.276 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.298288e-01 0.276 0 0
NADE modulates death signalling R-HSA-205025 5.298288e-01 0.276 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.298288e-01 0.276 0 0
Synthesis of DNA R-HSA-69239 5.310836e-01 0.275 0 0
Hedgehog 'off' state R-HSA-5610787 5.315084e-01 0.274 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.325960e-01 0.274 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.351573e-01 0.272 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.364158e-01 0.270 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.379977e-01 0.269 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.400384e-01 0.268 0 0
HIV Transcription Elongation R-HSA-167169 5.400384e-01 0.268 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.400384e-01 0.268 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.427647e-01 0.265 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.427647e-01 0.265 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.427647e-01 0.265 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.427647e-01 0.265 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.465947e-01 0.262 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.483439e-01 0.261 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.495682e-01 0.260 1 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.524052e-01 0.258 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.524052e-01 0.258 0 0
GAB1 signalosome R-HSA-180292 5.524052e-01 0.258 0 0
GPER1 signaling R-HSA-9634597 5.568216e-01 0.254 0 0
Toll-like Receptor Cascades R-HSA-168898 5.583416e-01 0.253 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.603550e-01 0.252 0 0
Interleukin-1 family signaling R-HSA-446652 5.620967e-01 0.250 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.624617e-01 0.250 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.624617e-01 0.250 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.624617e-01 0.250 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.624617e-01 0.250 0 0
NF-kB is activated and signals survival R-HSA-209560 5.624617e-01 0.250 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.632104e-01 0.249 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.649990e-01 0.248 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.649990e-01 0.248 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.649990e-01 0.248 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.713680e-01 0.243 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.714208e-01 0.243 0 0
Myogenesis R-HSA-525793 5.714208e-01 0.243 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.752985e-01 0.240 0 0
Adipogenesis R-HSA-9843745 5.767304e-01 0.239 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.802379e-01 0.236 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.802379e-01 0.236 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.802379e-01 0.236 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.810155e-01 0.236 0 0
Translesion Synthesis by POLH R-HSA-110320 5.810155e-01 0.236 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.810155e-01 0.236 0 0
Specification of the neural plate border R-HSA-9834899 5.810155e-01 0.236 0 0
Other interleukin signaling R-HSA-449836 5.810155e-01 0.236 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.841018e-01 0.234 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.854087e-01 0.233 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.854087e-01 0.233 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.854087e-01 0.233 0 0
Defective F9 activation R-HSA-9673221 5.854087e-01 0.233 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.854087e-01 0.233 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.854087e-01 0.233 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.854087e-01 0.233 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.854087e-01 0.233 0 0
Activation of AKT2 R-HSA-165158 5.854087e-01 0.233 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.854087e-01 0.233 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.854087e-01 0.233 0 0
Reelin signalling pathway R-HSA-8866376 5.854087e-01 0.233 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.854087e-01 0.233 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.854087e-01 0.233 0 0
Inositol transporters R-HSA-429593 5.854087e-01 0.233 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.854087e-01 0.233 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.854087e-01 0.233 0 0
Co-inhibition by BTLA R-HSA-9927353 5.854087e-01 0.233 0 0
NrCAM interactions R-HSA-447038 5.854087e-01 0.233 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.854087e-01 0.233 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.854087e-01 0.233 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.854087e-01 0.233 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.865070e-01 0.232 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.866683e-01 0.232 0 0
Signal amplification R-HSA-392518 5.866683e-01 0.232 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.866683e-01 0.232 0 0
PI3K Cascade R-HSA-109704 5.934006e-01 0.227 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.954655e-01 0.225 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.954655e-01 0.225 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.954655e-01 0.225 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.954655e-01 0.225 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.954655e-01 0.225 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.954655e-01 0.225 0 0
Protein ubiquitination R-HSA-8852135 5.959182e-01 0.225 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.973766e-01 0.224 0 0
Leishmania phagocytosis R-HSA-9664417 5.973766e-01 0.224 0 0
Parasite infection R-HSA-9664407 5.973766e-01 0.224 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.973806e-01 0.224 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.973806e-01 0.224 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.973806e-01 0.224 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.973806e-01 0.224 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.973806e-01 0.224 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.973806e-01 0.224 0 0
Interleukin-35 Signalling R-HSA-8984722 5.973806e-01 0.224 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.973806e-01 0.224 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.973806e-01 0.224 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.973806e-01 0.224 0 0
OAS antiviral response R-HSA-8983711 5.973806e-01 0.224 0 0
Leading Strand Synthesis R-HSA-69109 5.973806e-01 0.224 0 0
Polymerase switching R-HSA-69091 5.973806e-01 0.224 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.993635e-01 0.222 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.001075e-01 0.222 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.039173e-01 0.219 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.077353e-01 0.216 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.077353e-01 0.216 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.077353e-01 0.216 0 0
Protein hydroxylation R-HSA-9629569 6.084384e-01 0.216 0 0
Nephrin family interactions R-HSA-373753 6.084384e-01 0.216 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.111032e-01 0.214 0 0
Regulated Necrosis R-HSA-5218859 6.156420e-01 0.211 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.253201e-01 0.204 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.281692e-01 0.202 0 0
RNA Polymerase III Transcription R-HSA-74158 6.281692e-01 0.202 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.281692e-01 0.202 0 0
G1/S-Specific Transcription R-HSA-69205 6.281692e-01 0.202 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.283847e-01 0.202 0 0
Signaling by Insulin receptor R-HSA-74752 6.296328e-01 0.201 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.301611e-01 0.201 0 0
Formation of axial mesoderm R-HSA-9796292 6.301611e-01 0.201 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.301611e-01 0.201 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.301611e-01 0.201 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.301611e-01 0.201 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.301611e-01 0.201 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.301611e-01 0.201 0 0
Plus-strand DNA synthesis R-HSA-164525 6.344213e-01 0.198 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.344213e-01 0.198 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.344213e-01 0.198 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.344213e-01 0.198 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.344213e-01 0.198 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.344213e-01 0.198 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.344213e-01 0.198 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.344213e-01 0.198 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.344213e-01 0.198 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.344213e-01 0.198 0 0
PKB-mediated events R-HSA-109703 6.344213e-01 0.198 0 0
PDE3B signalling R-HSA-165160 6.344213e-01 0.198 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.344213e-01 0.198 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.344213e-01 0.198 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.344213e-01 0.198 0 0
Maturation of protein E R-HSA-9683683 6.344213e-01 0.198 0 0
Maturation of protein E R-HSA-9694493 6.344213e-01 0.198 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.344213e-01 0.198 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.346356e-01 0.197 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.346356e-01 0.197 0 0
ERK/MAPK targets R-HSA-198753 6.346356e-01 0.197 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.346356e-01 0.197 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.346356e-01 0.197 0 0
Basigin interactions R-HSA-210991 6.346356e-01 0.197 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.346356e-01 0.197 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.346356e-01 0.197 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.346356e-01 0.197 0 0
G1 Phase R-HSA-69236 6.369839e-01 0.196 0 0
Cyclin D associated events in G1 R-HSA-69231 6.369839e-01 0.196 0 0
Proteasome assembly R-HSA-9907900 6.369839e-01 0.196 0 0
PCP/CE pathway R-HSA-4086400 6.395969e-01 0.194 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.410538e-01 0.193 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.410538e-01 0.193 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.410538e-01 0.193 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.452264e-01 0.190 0 0
Stimuli-sensing channels R-HSA-2672351 6.461071e-01 0.190 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.462444e-01 0.190 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.477496e-01 0.189 0 0
Degradation of AXIN R-HSA-4641257 6.479449e-01 0.188 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.479449e-01 0.188 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.493648e-01 0.188 0 0
Interleukin-1 signaling R-HSA-9020702 6.504986e-01 0.187 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.548524e-01 0.184 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.548524e-01 0.184 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.548524e-01 0.184 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.548524e-01 0.184 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.595847e-01 0.181 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.595847e-01 0.181 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.595847e-01 0.181 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.595847e-01 0.181 0 0
Removal of the Flap Intermediate R-HSA-69166 6.608209e-01 0.180 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.608209e-01 0.180 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.608209e-01 0.180 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.608209e-01 0.180 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.608209e-01 0.180 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.608209e-01 0.180 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 6.608209e-01 0.180 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.608209e-01 0.180 0 0
Pyruvate metabolism R-HSA-70268 6.609447e-01 0.180 0 0
Signaling by Hedgehog R-HSA-5358351 6.639138e-01 0.178 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.744928e-01 0.171 0 0
Mitochondrial biogenesis R-HSA-1592230 6.760462e-01 0.170 0 0
Signaling by LTK in cancer R-HSA-9842640 6.776422e-01 0.169 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 6.776422e-01 0.169 0 0
Uncoating of the HIV Virion R-HSA-162585 6.776422e-01 0.169 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.776422e-01 0.169 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.776422e-01 0.169 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.776422e-01 0.169 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.776422e-01 0.169 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.776422e-01 0.169 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.776422e-01 0.169 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.776422e-01 0.169 0 0
Abacavir transmembrane transport R-HSA-2161517 6.776422e-01 0.169 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.776422e-01 0.169 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.776422e-01 0.169 0 0
Chylomicron clearance R-HSA-8964026 6.776422e-01 0.169 0 0
HDL clearance R-HSA-8964011 6.776422e-01 0.169 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.831384e-01 0.165 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.831384e-01 0.165 0 0
Notch-HLH transcription pathway R-HSA-350054 6.832773e-01 0.165 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.832773e-01 0.165 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.832773e-01 0.165 0 0
LDL clearance R-HSA-8964038 6.832773e-01 0.165 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.854494e-01 0.164 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.854494e-01 0.164 0 0
ER-Phagosome pathway R-HSA-1236974 6.864795e-01 0.163 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.894031e-01 0.162 0 0
Translesion synthesis by REV1 R-HSA-110312 6.894031e-01 0.162 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.894031e-01 0.162 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.894031e-01 0.162 0 0
Protein lipoylation R-HSA-9857492 6.894031e-01 0.162 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.894031e-01 0.162 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 6.894031e-01 0.162 0 0
Signaling by Activin R-HSA-1502540 6.894031e-01 0.162 0 0
Biotin transport and metabolism R-HSA-196780 6.894031e-01 0.162 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.921572e-01 0.160 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.921572e-01 0.160 0 0
Cellular response to hypoxia R-HSA-1234174 6.973113e-01 0.157 0 0
Signaling by FGFR in disease R-HSA-1226099 7.017898e-01 0.154 0 0
Parasitic Infection Pathways R-HSA-9824443 7.024189e-01 0.153 0 0
Leishmania infection R-HSA-9658195 7.024189e-01 0.153 0 0
Signaling by WNT in cancer R-HSA-4791275 7.028341e-01 0.153 0 0
DNA strand elongation R-HSA-69190 7.028341e-01 0.153 0 0
Platelet degranulation R-HSA-114608 7.029896e-01 0.153 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.031547e-01 0.153 0 0
Glycogen metabolism R-HSA-8982491 7.031547e-01 0.153 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.048722e-01 0.152 0 0
Gluconeogenesis R-HSA-70263 7.050934e-01 0.152 0 0
Metal ion SLC transporters R-HSA-425410 7.050934e-01 0.152 0 0
Interleukin-20 family signaling R-HSA-8854691 7.057170e-01 0.151 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.057170e-01 0.151 0 0
Carnitine shuttle R-HSA-200425 7.057170e-01 0.151 0 0
Mitochondrial mRNA modification R-HSA-9937008 7.057170e-01 0.151 0 0
Syndecan interactions R-HSA-3000170 7.057170e-01 0.151 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.063133e-01 0.151 0 0
Vesicle-mediated transport R-HSA-5653656 7.150148e-01 0.146 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.157554e-01 0.145 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.157554e-01 0.145 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.157554e-01 0.145 0 0
Recycling of eIF2:GDP R-HSA-72731 7.157554e-01 0.145 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.157554e-01 0.145 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.157554e-01 0.145 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.157554e-01 0.145 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.157554e-01 0.145 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.157554e-01 0.145 0 0
Mitochondrial ABC transporters R-HSA-1369007 7.157554e-01 0.145 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.157554e-01 0.145 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.157554e-01 0.145 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.157554e-01 0.145 0 0
VLDL clearance R-HSA-8964046 7.157554e-01 0.145 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.157554e-01 0.145 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.157554e-01 0.145 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.157554e-01 0.145 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.157554e-01 0.145 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.159704e-01 0.145 0 0
Translesion synthesis by POLI R-HSA-5656121 7.159704e-01 0.145 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.159704e-01 0.145 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.159704e-01 0.145 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.159704e-01 0.145 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.159704e-01 0.145 0 0
Activation of SMO R-HSA-5635838 7.159704e-01 0.145 0 0
Mineralocorticoid biosynthesis R-HSA-193993 7.159704e-01 0.145 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.159704e-01 0.145 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.201540e-01 0.143 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.201540e-01 0.143 0 0
G-protein beta:gamma signalling R-HSA-397795 7.216285e-01 0.142 0 0
Nuclear RNA decay R-HSA-9930044 7.216285e-01 0.142 0 0
Cardiogenesis R-HSA-9733709 7.216285e-01 0.142 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.216285e-01 0.142 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.269176e-01 0.139 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.269176e-01 0.139 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.269176e-01 0.139 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.269176e-01 0.139 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.364465e-01 0.133 0 0
HIV Transcription Initiation R-HSA-167161 7.364465e-01 0.133 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.364465e-01 0.133 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.364465e-01 0.133 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.364465e-01 0.133 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.380989e-01 0.132 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.395266e-01 0.131 0 0
Glutamate and glutamine metabolism R-HSA-8964539 7.395266e-01 0.131 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.405995e-01 0.130 0 0
Translesion synthesis by POLK R-HSA-5655862 7.405995e-01 0.130 0 0
Passive transport by Aquaporins R-HSA-432047 7.405995e-01 0.130 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.405995e-01 0.130 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.405995e-01 0.130 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.405995e-01 0.130 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.405995e-01 0.130 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.405995e-01 0.130 0 0
Fibronectin matrix formation R-HSA-1566977 7.405995e-01 0.130 0 0
Coenzyme A biosynthesis R-HSA-196783 7.405995e-01 0.130 0 0
Synthesis of PG R-HSA-1483148 7.405995e-01 0.130 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 7.405995e-01 0.130 0 0
Response to metal ions R-HSA-5660526 7.405995e-01 0.130 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.407485e-01 0.130 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.469013e-01 0.127 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.469013e-01 0.127 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.493644e-01 0.125 0 0
Minus-strand DNA synthesis R-HSA-164516 7.493644e-01 0.125 0 0
RSK activation R-HSA-444257 7.493644e-01 0.125 0 0
phospho-PLA2 pathway R-HSA-111995 7.493644e-01 0.125 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.493644e-01 0.125 0 0
MET receptor recycling R-HSA-8875656 7.493644e-01 0.125 0 0
Interleukin-23 signaling R-HSA-9020933 7.493644e-01 0.125 0 0
Activation of RAS in B cells R-HSA-1169092 7.493644e-01 0.125 0 0
Fructose biosynthesis R-HSA-5652227 7.493644e-01 0.125 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.493644e-01 0.125 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.493644e-01 0.125 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.493644e-01 0.125 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.493644e-01 0.125 0 0
Calcitonin-like ligand receptors R-HSA-419812 7.493644e-01 0.125 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.493644e-01 0.125 0 0
tRNA Aminoacylation R-HSA-379724 7.498048e-01 0.125 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.501308e-01 0.125 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.520990e-01 0.124 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.536772e-01 0.123 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.565381e-01 0.121 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.627726e-01 0.118 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.633774e-01 0.117 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.633774e-01 0.117 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.633774e-01 0.117 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.633774e-01 0.117 0 0
Glycogen storage diseases R-HSA-3229121 7.633774e-01 0.117 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.633774e-01 0.117 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.639794e-01 0.117 0 0
MET activates PTK2 signaling R-HSA-8874081 7.656974e-01 0.116 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.656974e-01 0.116 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.656974e-01 0.116 0 0
Urea cycle R-HSA-70635 7.656974e-01 0.116 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.669249e-01 0.115 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.669249e-01 0.115 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.715812e-01 0.113 0 0
Signaling by PDGF R-HSA-186797 7.752457e-01 0.111 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.790012e-01 0.108 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.790012e-01 0.108 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.790012e-01 0.108 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.790012e-01 0.108 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.790012e-01 0.108 0 0
mRNA Editing R-HSA-75072 7.790012e-01 0.108 0 0
Calcineurin activates NFAT R-HSA-2025928 7.790012e-01 0.108 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.790012e-01 0.108 0 0
Expression of NOTCH2NL genes R-HSA-9911233 7.790012e-01 0.108 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.790012e-01 0.108 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.790012e-01 0.108 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.790012e-01 0.108 0 0
Interleukin-1 processing R-HSA-448706 7.790012e-01 0.108 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.790012e-01 0.108 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.790012e-01 0.108 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.790012e-01 0.108 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.790012e-01 0.108 0 0
Potential therapeutics for SARS R-HSA-9679191 7.823933e-01 0.107 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.833406e-01 0.106 0 0
Cristae formation R-HSA-8949613 7.833406e-01 0.106 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.833406e-01 0.106 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.833406e-01 0.106 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.843974e-01 0.105 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.843974e-01 0.105 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.843974e-01 0.105 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.843974e-01 0.105 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.843974e-01 0.105 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.858304e-01 0.105 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.879622e-01 0.103 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.879622e-01 0.103 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.946487e-01 0.100 0 0
Downstream TCR signaling R-HSA-202424 7.955060e-01 0.099 0 0
Telomere Extension By Telomerase R-HSA-171319 7.998702e-01 0.097 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.998702e-01 0.097 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.998702e-01 0.097 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.998702e-01 0.097 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.998702e-01 0.097 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.998702e-01 0.097 0 0
Pyroptosis R-HSA-5620971 7.998702e-01 0.097 0 0
G alpha (z) signalling events R-HSA-418597 8.020950e-01 0.096 1 1
Voltage gated Potassium channels R-HSA-1296072 8.024138e-01 0.096 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.037567e-01 0.095 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.037567e-01 0.095 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.037567e-01 0.095 0 0
Diseases of hemostasis R-HSA-9671793 8.037567e-01 0.095 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.037567e-01 0.095 0 0
Binding and entry of HIV virion R-HSA-173107 8.051351e-01 0.094 0 0
Josephin domain DUBs R-HSA-5689877 8.051351e-01 0.094 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.051351e-01 0.094 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.051351e-01 0.094 0 0
Metabolism of serotonin R-HSA-380612 8.051351e-01 0.094 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.051351e-01 0.094 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.051351e-01 0.094 0 0
Maturation of spike protein R-HSA-9683686 8.051351e-01 0.094 0 0
Sperm Motility And Taxes R-HSA-1300642 8.051351e-01 0.094 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.051351e-01 0.094 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.051351e-01 0.094 0 0
Platelet homeostasis R-HSA-418346 8.053113e-01 0.094 0 0
Signaling by ERBB4 R-HSA-1236394 8.072495e-01 0.093 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.075073e-01 0.093 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.075073e-01 0.093 0 0
Neddylation R-HSA-8951664 8.088478e-01 0.092 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.136843e-01 0.090 0 0
IRE1alpha activates chaperones R-HSA-381070 8.143623e-01 0.089 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.197170e-01 0.086 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.215540e-01 0.085 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.215540e-01 0.085 0 0
Signaling by NODAL R-HSA-1181150 8.215540e-01 0.085 0 0
Interferon alpha/beta signaling R-HSA-909733 8.222223e-01 0.085 0 0
ABC-family proteins mediated transport R-HSA-382556 8.224747e-01 0.085 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.240461e-01 0.084 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.250328e-01 0.084 0 0
vRNP Assembly R-HSA-192905 8.281799e-01 0.082 0 0
vRNA Synthesis R-HSA-192814 8.281799e-01 0.082 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.281799e-01 0.082 0 0
Synthesis of PI R-HSA-1483226 8.281799e-01 0.082 0 0
Bicarbonate transporters R-HSA-425381 8.281799e-01 0.082 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.281799e-01 0.082 0 0
Suppression of apoptosis R-HSA-9635465 8.281799e-01 0.082 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.289138e-01 0.081 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.297612e-01 0.081 0 0
Intraflagellar transport R-HSA-5620924 8.312949e-01 0.080 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.352542e-01 0.078 0 0
G-protein activation R-HSA-202040 8.378879e-01 0.077 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.378879e-01 0.077 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.378879e-01 0.077 0 0
Lagging Strand Synthesis R-HSA-69186 8.378879e-01 0.077 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.378879e-01 0.077 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.378879e-01 0.077 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.401498e-01 0.076 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.410154e-01 0.075 0 0
ABC transporter disorders R-HSA-5619084 8.451422e-01 0.073 0 0
Interferon gamma signaling R-HSA-877300 8.454522e-01 0.073 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.480994e-01 0.072 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.485006e-01 0.071 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.485006e-01 0.071 0 0
ERKs are inactivated R-HSA-202670 8.485006e-01 0.071 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.485006e-01 0.071 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.485006e-01 0.071 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.485006e-01 0.071 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.485006e-01 0.071 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.485006e-01 0.071 0 0
Azathioprine ADME R-HSA-9748787 8.526296e-01 0.069 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.528556e-01 0.069 0 0
Assembly Of The HIV Virion R-HSA-175474 8.528556e-01 0.069 0 0
Glucocorticoid biosynthesis R-HSA-194002 8.528556e-01 0.069 0 0
Androgen biosynthesis R-HSA-193048 8.528556e-01 0.069 0 0
Ribavirin ADME R-HSA-9755088 8.528556e-01 0.069 0 0
RAB geranylgeranylation R-HSA-8873719 8.547674e-01 0.068 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.547674e-01 0.068 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.557354e-01 0.068 0 0
COPII-mediated vesicle transport R-HSA-204005 8.579576e-01 0.067 0 0
Potassium Channels R-HSA-1296071 8.630645e-01 0.064 0 0
tRNA processing R-HSA-72306 8.633456e-01 0.064 0 0
Aquaporin-mediated transport R-HSA-445717 8.637888e-01 0.064 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.637888e-01 0.064 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.664191e-01 0.062 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.664191e-01 0.062 0 0
Repression of WNT target genes R-HSA-4641265 8.664191e-01 0.062 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.664191e-01 0.062 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.665516e-01 0.062 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.665516e-01 0.062 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.665516e-01 0.062 0 0
Ethanol oxidation R-HSA-71384 8.665516e-01 0.062 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.665516e-01 0.062 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.665516e-01 0.062 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.665516e-01 0.062 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.665516e-01 0.062 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.673725e-01 0.062 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.700930e-01 0.060 0 0
Neurexins and neuroligins R-HSA-6794361 8.716698e-01 0.060 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.716698e-01 0.060 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.723406e-01 0.059 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.730716e-01 0.059 0 0
PPARA activates gene expression R-HSA-1989781 8.741329e-01 0.058 0 0
Regulation of insulin secretion R-HSA-422356 8.768282e-01 0.057 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.781733e-01 0.056 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.790674e-01 0.056 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.790674e-01 0.056 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.822192e-01 0.054 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.822192e-01 0.054 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.822192e-01 0.054 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.822192e-01 0.054 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.822192e-01 0.054 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.822192e-01 0.054 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.822192e-01 0.054 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.824405e-01 0.054 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.838995e-01 0.054 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.845441e-01 0.053 0 0
Infectious disease R-HSA-5663205 8.878372e-01 0.052 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.881851e-01 0.051 0 0
Hyaluronan metabolism R-HSA-2142845 8.881851e-01 0.051 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.881851e-01 0.051 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.904905e-01 0.050 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.911222e-01 0.050 0 0
Amine ligand-binding receptors R-HSA-375280 8.912017e-01 0.050 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.961512e-01 0.048 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.961512e-01 0.048 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.961512e-01 0.048 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.961512e-01 0.048 0 0
Hydrolysis of LPC R-HSA-1483115 8.961512e-01 0.048 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.961512e-01 0.048 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.961512e-01 0.048 0 0
cGMP effects R-HSA-418457 8.961512e-01 0.048 0 0
Prolactin receptor signaling R-HSA-1170546 8.961512e-01 0.048 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.961512e-01 0.048 0 0
Ciprofloxacin ADME R-HSA-9793528 8.961512e-01 0.048 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.961512e-01 0.048 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.961512e-01 0.048 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.969731e-01 0.047 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.970589e-01 0.047 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.987913e-01 0.046 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.993853e-01 0.046 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.993853e-01 0.046 0 0
Somitogenesis R-HSA-9824272 8.993853e-01 0.046 0 0
Laminin interactions R-HSA-3000157 9.009042e-01 0.045 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.009042e-01 0.045 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.009042e-01 0.045 0 0
Hyaluronan degradation R-HSA-2160916 9.009042e-01 0.045 0 0
Formation of the nephric duct R-HSA-9830364 9.009042e-01 0.045 0 0
PI Metabolism R-HSA-1483255 9.009832e-01 0.045 0 0
Mitochondrial protein degradation R-HSA-9837999 9.044981e-01 0.044 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.084360e-01 0.042 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.084360e-01 0.042 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.084360e-01 0.042 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.084360e-01 0.042 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.084360e-01 0.042 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.084360e-01 0.042 0 0
Protein repair R-HSA-5676934 9.084360e-01 0.042 0 0
Other semaphorin interactions R-HSA-416700 9.084360e-01 0.042 0 0
Kidney development R-HSA-9830369 9.086248e-01 0.042 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.103874e-01 0.041 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.103874e-01 0.041 0 0
Integrin cell surface interactions R-HSA-216083 9.140205e-01 0.039 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.141376e-01 0.039 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.156932e-01 0.038 0 0
RSV-host interactions R-HSA-9833110 9.163912e-01 0.038 0 0
Signaling by BMP R-HSA-201451 9.190145e-01 0.037 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.190145e-01 0.037 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.190145e-01 0.037 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.190145e-01 0.037 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.192682e-01 0.037 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.192682e-01 0.037 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.192682e-01 0.037 0 0
Carnitine synthesis R-HSA-71262 9.192682e-01 0.037 0 0
Regulation of BACH1 activity R-HSA-9708530 9.192682e-01 0.037 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.192682e-01 0.037 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.212473e-01 0.036 0 0
Extension of Telomeres R-HSA-180786 9.226949e-01 0.035 0 0
Regulation of beta-cell development R-HSA-186712 9.226949e-01 0.035 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.265649e-01 0.033 0 0
Insulin receptor recycling R-HSA-77387 9.268553e-01 0.033 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.269281e-01 0.033 0 0
RAS processing R-HSA-9648002 9.279809e-01 0.032 0 0
Pentose phosphate pathway R-HSA-71336 9.279809e-01 0.032 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.279809e-01 0.032 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.282855e-01 0.032 0 0
Metabolism of polyamines R-HSA-351202 9.282855e-01 0.032 0 0
Glycine degradation R-HSA-6783984 9.288195e-01 0.032 0 0
Heme assimilation R-HSA-9927020 9.288195e-01 0.032 0 0
Phase 2 - plateau phase R-HSA-5576893 9.288195e-01 0.032 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.288195e-01 0.032 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.288195e-01 0.032 0 0
mRNA Capping R-HSA-72086 9.339749e-01 0.030 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.339749e-01 0.030 0 0
Glucagon-type ligand receptors R-HSA-420092 9.339749e-01 0.030 0 0
DARPP-32 events R-HSA-180024 9.339749e-01 0.030 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.341817e-01 0.030 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.372412e-01 0.028 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.372412e-01 0.028 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.372412e-01 0.028 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.372412e-01 0.028 0 0
Choline catabolism R-HSA-6798163 9.372412e-01 0.028 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.372412e-01 0.028 0 0
Mitochondrial protein import R-HSA-1268020 9.383968e-01 0.028 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.404344e-01 0.027 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.404344e-01 0.027 0 0
Neurotransmitter clearance R-HSA-112311 9.404344e-01 0.027 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.442635e-01 0.025 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.446670e-01 0.025 0 0
PKA activation in glucagon signalling R-HSA-164378 9.446670e-01 0.025 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.446670e-01 0.025 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.446670e-01 0.025 0 0
PKA activation R-HSA-163615 9.446670e-01 0.025 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.446670e-01 0.025 0 0
Apoptotic factor-mediated response R-HSA-111471 9.446670e-01 0.025 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.451302e-01 0.025 0 0
Intra-Golgi traffic R-HSA-6811438 9.451302e-01 0.025 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.462026e-01 0.024 0 0
Budding and maturation of HIV virion R-HSA-162588 9.462901e-01 0.024 0 0
Cargo concentration in the ER R-HSA-5694530 9.462901e-01 0.024 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.462901e-01 0.024 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.462901e-01 0.024 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.474810e-01 0.023 0 0
Activation of GABAB receptors R-HSA-991365 9.499461e-01 0.022 0 0
GABA B receptor activation R-HSA-977444 9.499461e-01 0.022 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.512145e-01 0.022 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.512145e-01 0.022 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.512145e-01 0.022 0 0
Pyrimidine biosynthesis R-HSA-500753 9.512145e-01 0.022 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.512145e-01 0.022 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.512145e-01 0.022 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.515945e-01 0.022 0 0
G0 and Early G1 R-HSA-1538133 9.515945e-01 0.022 0 0
Recycling of bile acids and salts R-HSA-159418 9.563961e-01 0.019 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.569876e-01 0.019 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.569876e-01 0.019 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.569876e-01 0.019 0 0
Creatine metabolism R-HSA-71288 9.569876e-01 0.019 0 0
Pregnenolone biosynthesis R-HSA-196108 9.569876e-01 0.019 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.607394e-01 0.017 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.620778e-01 0.017 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.620778e-01 0.017 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.621299e-01 0.017 0 0
Synthesis of PA R-HSA-1483166 9.626048e-01 0.017 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.646658e-01 0.016 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.646658e-01 0.016 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.655289e-01 0.015 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.655289e-01 0.015 0 0
Serine metabolism R-HSA-977347 9.665659e-01 0.015 0 0
Glutathione synthesis and recycling R-HSA-174403 9.665659e-01 0.015 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.672124e-01 0.014 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.682130e-01 0.014 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.682130e-01 0.014 0 0
Oncogene Induced Senescence R-HSA-2559585 9.682130e-01 0.014 0 0
Fructose metabolism R-HSA-5652084 9.705231e-01 0.013 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.705231e-01 0.013 0 0
Innate Immune System R-HSA-168249 9.709749e-01 0.013 1 0
Triglyceride catabolism R-HSA-163560 9.714159e-01 0.013 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.730399e-01 0.012 0 0
Collagen degradation R-HSA-1442490 9.735978e-01 0.012 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.740121e-01 0.011 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.740121e-01 0.011 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.743060e-01 0.011 0 0
Elastic fibre formation R-HSA-1566948 9.769127e-01 0.010 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.770883e-01 0.010 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.770883e-01 0.010 0 0
Iron uptake and transport R-HSA-917937 9.782578e-01 0.010 0 0
Transmission across Chemical Synapses R-HSA-112315 9.785563e-01 0.009 0 0
The phototransduction cascade R-HSA-2514856 9.786158e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.792358e-01 0.009 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.792626e-01 0.009 0 0
G alpha (s) signalling events R-HSA-418555 9.797323e-01 0.009 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.798005e-01 0.009 0 0
G protein gated Potassium channels R-HSA-1296059 9.798005e-01 0.009 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.798005e-01 0.009 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.798005e-01 0.009 0 0
Fertilization R-HSA-1187000 9.798005e-01 0.009 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.798005e-01 0.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.799996e-01 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.821918e-01 0.008 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.821918e-01 0.008 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.821918e-01 0.008 0 0
Abacavir ADME R-HSA-2161522 9.821918e-01 0.008 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.821918e-01 0.008 0 0
Nucleotide biosynthesis R-HSA-8956320 9.823890e-01 0.008 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.832864e-01 0.007 0 0
Maturation of spike protein R-HSA-9694548 9.832864e-01 0.007 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.832864e-01 0.007 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.843002e-01 0.007 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.843002e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.849147e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9683701 9.850028e-01 0.007 0 0
Paracetamol ADME R-HSA-9753281 9.855203e-01 0.006 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.861590e-01 0.006 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.865472e-01 0.006 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.877979e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.877979e-01 0.005 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.877979e-01 0.005 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.879362e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.881135e-01 0.005 0 0
Neuronal System R-HSA-112316 9.890158e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.891850e-01 0.005 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.892363e-01 0.005 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.892422e-01 0.005 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.892427e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.899513e-01 0.004 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.902566e-01 0.004 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.903073e-01 0.004 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.903552e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.903552e-01 0.004 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.905166e-01 0.004 0 0
Ca2+ pathway R-HSA-4086398 9.911029e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.911834e-01 0.004 0 0
Glutathione conjugation R-HSA-156590 9.911834e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.914458e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.919420e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.922210e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.922561e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.923089e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.933990e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.934806e-01 0.003 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.935028e-01 0.003 0 0
Heme degradation R-HSA-189483 9.935028e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.937633e-01 0.003 0 0
eNOS activation R-HSA-203615 9.942723e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.942723e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.944178e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.944376e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.949508e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.950048e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.951931e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.952417e-01 0.002 0 0
Protein localization R-HSA-9609507 9.954525e-01 0.002 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.955311e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.956600e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.958492e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.958492e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.960762e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.960762e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.961166e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.962092e-01 0.002 0 0
Glucuronidation R-HSA-156588 9.964255e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.964580e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.965411e-01 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.965411e-01 0.002 0 0
Biofilm formation R-HSA-9931953 9.965411e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.969509e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.971243e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.973711e-01 0.001 0 0
Disease R-HSA-1643685 9.974654e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.977807e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.979115e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.979115e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.979622e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.983746e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.983772e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.984194e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.984611e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.985695e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.986300e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.987530e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.988437e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.988563e-01 0.000 1 1
Chemokine receptors bind chemokines R-HSA-380108 9.992388e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.993597e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.993813e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.994086e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.994086e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.994184e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994737e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.995074e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.995872e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.996367e-01 0.000 1 0
Metabolism of amine-derived hormones R-HSA-209776 9.996854e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997682e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.997846e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.997982e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998293e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998544e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998830e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998855e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999010e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999108e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999114e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999173e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999186e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999216e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999309e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999331e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999521e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999527e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999527e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999527e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999527e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999527e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999583e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999606e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999715e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999750e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999805e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999866e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999913e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999914e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999932e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999941e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999951e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999954e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999977e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999977e-01 0.000 1 0
Scavenging of heme from plasma R-HSA-2168880 9.999984e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999984e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999988e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999992e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999994e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999996e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999998e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 1 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways