PERK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NMY6 S164 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O14950 T129 Sugiyama MYL12B MRLC2 MYLC2B CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
O14950 T160 Sugiyama MYL12B MRLC2 MYLC2B DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60841 T92 Sugiyama EIF5B IF2 KIAA0741 IKADREtVAVKPTENNEEEFtsKDKKKKGQKGKKQsFDDND
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95218 S165 Sugiyama ZRANB2 ZIS ZNF265 LKEVEDKEsEGEEEDEDEDLsKyKLDEDEDEDDADLsKyNL
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P05198 S49 EPSD|PSP EIF2S1 EIF2A EMGAYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNE
P05198 S52 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2S1 EIF2A AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S164 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P08670 S299 Sugiyama VIM VAAKNLQEAEEWyKSKFADLsEAANRNNDALRQAKQESTEY
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09467 S170 PSP FBP1 FBP EKDALQPGRNLVAAGYALYGsATMLVLAMDCGVNCFMLDPA
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10412 T45 Sugiyama H1-4 H1F4 HIST1H1E RKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P14314 T115 Sugiyama PRKCSH G19P1 GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14854 S52 Sugiyama COX6B1 COX6B QNyLDFHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTD
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311 T425 Sugiyama EZR VIL2 RQAVDQIKsQEQLAAELAEytAKIALLEEARRRKEDEVEEW
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P16402 T46 Sugiyama H1-3 H1F3 HIST1H1D KAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16403 T45 Sugiyama H1-2 H1F2 HIST1H1C AKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P19105 T128 Sugiyama MYL12A MLCB MRLC3 RLC CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
P19105 T159 Sugiyama MYL12A MLCB MRLC3 RLC DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20290 S201 Sugiyama BTF3 NACB OK/SW-cl.8 AtGEDDDDEVPDLVENFDEAsKNEAN_______________
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 Y68 Sugiyama CFL1 CFL ILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAt
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24844 T129 Sugiyama MYL9 MLC2 MRLC1 MYRL2 CFDEEASGFIHEDHLRELLttMGDRFtDEEVDEMyREAPID
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401 T342 Sugiyama TKT GQALAKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIEC
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P35579 S1154 Sugiyama MYH9 KRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNILKK
P35579 S1713 Sugiyama MYH9 ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35579 S1915 Sugiyama MYH9 KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579 T1146 Sugiyama MYH9 sRNKAEKQKRDLGEELEALKtELEDtLDstAAQQELRSKRE
P35579 T1155 Sugiyama MYH9 RDLGEELEALKtELEDtLDstAAQQELRSKREQEVNILKKT
P35579 T1208 Sugiyama MYH9 QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35580 T1911 Sugiyama MYH10 EEATRANASRRKLQRELDDAtEANEGLSREVSTLKNRLRRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P39019 T55 Sugiyama RPS19 DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S9 Sugiyama SUB1 PC4 RPO2TC1 ____________MPKSKELVsssssGsDsDsEVDKKLKRKK
P58546 T108 Sugiyama MTPN LSKGADKTVKGPDGLTAFEAtDNQAIKALLQ__________
P60660 T22 Sugiyama MYL6 CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61247 S203 Sugiyama RPS3A FTE1 MFTL EVVNKLIPDsIGKDIEKACQsIyPLHDVFVRKVKMLKKPKF
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 Y205 Sugiyama RPS3A FTE1 MFTL VNKLIPDsIGKDIEKACQsIyPLHDVFVRKVKMLKKPKFEL
P61254 S12 Sugiyama RPL26 _________MKFNPFVtsDRsKNRKRHFNAPsHIRRKIMss
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62857 T38 Sugiyama RPS28 LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62979 T147 Sugiyama RPS27A UBA80 UBCEP1 GAGVFMAsHFDRHyCGKCCLtyCFNKPEDK___________
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P67809 S314 Sugiyama YBX1 NSEP1 YB1 NPKPQDGKETKAADPPAENssAPEAEQGGAE__________
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q08J23 S593 Sugiyama NSUN2 SAKI TRM4 NNSEKMKVINTGIKVWCRNNsGEEFDCAFRLAQEGIYTLYP
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13428 S1376 Sugiyama TCOF1 ARtPRSKKKKKLGAGEGGEAsVsPEKtsttSKGKAKRDKAS
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q14247 T328 Sugiyama CTTN EMS1 GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q14444 T103 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 NKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFMALsQDI
Q14684 S392 Sugiyama RRP1B KIAA0179 EKTNLEKEKGSRVFCVEEEDsEssLQKRRRKKKKKHHLQPE
Q15056 S110 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 DEVDsLKEALtyDGALLGDRsLRVDIAEGRKQDKGGFGFRK
Q27J81 S1202 Sugiyama INF2 C14orf151 C14orf173 EsALDtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRR
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96SQ9 T131 Sugiyama CYP2S1 UNQ891/PRO1906 FDGHGVFFSNGERWRQLRKFtMLALRDLGMGKREGEELIQA
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BQ16 T118 Sugiyama SPOCK3 TICN3 UNQ409/PRO771 HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H1E3 Y146 Sugiyama NUCKS1 NUCKS JC7 QEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPERKE
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NZJ5 S715 Sugiyama EIF2AK3 PEK PERK VKIRRMDPFATKEHIEIIAPsPQRsRSFSVGISCDQTSSSE
Q9NZJ5 T982 PSP EIF2AK3 PEK PERK MDQDEEEQTVLTPMPAYARHtGQVGTKLYMSPEQIHGNSYS
Q9NZJ5 Y619 SIGNOR EIF2AK3 PEK PERK LGRGGFGVVFEAKNKVDDCNyAIKRIRLPNRELAREKVMRE
Q9UNX3 S12 Sugiyama RPL26L1 RPL26P1 _________MKFNPFVtsDRsKNRKRHFNAPSHVRRKIMss
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.756795e-12 11.110 0 0
Cell Cycle, Mitotic R-HSA-69278 5.189422e-10 9.285 0 0
Mitotic Prometaphase R-HSA-68877 1.671072e-09 8.777 0 0
G2/M Transition R-HSA-69275 2.284455e-09 8.641 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.938838e-09 8.532 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.622142e-08 7.118 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.615088e-08 7.017 0 0
Signaling by Hippo R-HSA-2028269 9.694096e-08 7.013 0 0
M Phase R-HSA-68886 2.417874e-07 6.617 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.512625e-07 6.454 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.257009e-07 6.371 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.580335e-07 6.253 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.626798e-07 6.064 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.278566e-06 5.893 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.947247e-06 5.711 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.657785e-06 5.575 0 0
Interleukin-12 signaling R-HSA-9020591 2.981623e-06 5.526 0 0
Apoptotic execution phase R-HSA-75153 4.544424e-06 5.343 0 0
Mitotic Anaphase R-HSA-68882 4.390376e-06 5.357 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.784852e-06 5.320 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.283195e-06 5.202 0 0
Co-stimulation by CD28 R-HSA-389356 6.813902e-06 5.167 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.254880e-06 5.139 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.254880e-06 5.139 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.312603e-06 5.031 0 0
Centrosome maturation R-HSA-380287 9.888343e-06 5.005 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.365672e-05 4.865 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.739818e-05 4.759 0 0
Interleukin-12 family signaling R-HSA-447115 1.754288e-05 4.756 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.876321e-05 4.727 1 0
Nervous system development R-HSA-9675108 2.044276e-05 4.689 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.278303e-05 4.642 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.278303e-05 4.642 0 0
Axon guidance R-HSA-422475 2.289376e-05 4.640 0 0
Aggrephagy R-HSA-9646399 2.480263e-05 4.606 0 0
Recycling pathway of L1 R-HSA-437239 2.549580e-05 4.594 0 0
Separation of Sister Chromatids R-HSA-2467813 3.101846e-05 4.508 0 0
Gap junction trafficking and regulation R-HSA-157858 3.657881e-05 4.437 0 0
Signaling by LTK R-HSA-9842663 4.795665e-05 4.319 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.032926e-05 4.298 0 0
Signaling by NTRKs R-HSA-166520 5.135478e-05 4.289 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.507368e-05 4.259 0 0
Kinesins R-HSA-983189 5.536293e-05 4.257 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.899093e-05 4.229 0 0
Selective autophagy R-HSA-9663891 6.719499e-05 4.173 0 0
Cilium Assembly R-HSA-5617833 1.149750e-04 3.939 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.113496e-04 3.953 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.221872e-04 3.913 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.184894e-04 3.926 0 0
Signal Transduction R-HSA-162582 1.277045e-04 3.894 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.334908e-04 3.875 0 0
Gap junction assembly R-HSA-190861 1.659234e-04 3.780 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.047793e-04 3.689 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.219137e-04 3.654 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.669016e-04 3.574 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.660515e-04 3.575 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.376891e-04 3.624 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.704365e-04 3.568 0 0
L1CAM interactions R-HSA-373760 2.611938e-04 3.583 0 0
Gap junction trafficking R-HSA-190828 2.682574e-04 3.571 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.508026e-04 3.601 1 1
Signaling by ALK in cancer R-HSA-9700206 2.508026e-04 3.601 1 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.672301e-04 3.435 0 0
Cell Cycle Checkpoints R-HSA-69620 4.692492e-04 3.329 0 0
Regulation of signaling by CBL R-HSA-912631 5.538082e-04 3.257 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.787669e-04 3.237 0 0
Signaling by VEGF R-HSA-194138 6.325438e-04 3.199 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.087514e-04 3.216 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.585955e-04 3.181 0 0
Regulation of KIT signaling R-HSA-1433559 6.901452e-04 3.161 0 0
Cellular responses to stress R-HSA-2262752 7.501150e-04 3.125 1 0
PKR-mediated signaling R-HSA-9833482 7.278091e-04 3.138 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.576878e-04 3.121 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.576878e-04 3.121 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.109664e-04 3.091 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.337868e-04 3.079 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.208547e-04 3.086 0 0
Regulation of TP53 Activity R-HSA-5633007 8.365774e-04 3.077 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.100026e-04 3.041 0 0
GPVI-mediated activation cascade R-HSA-114604 1.013654e-03 2.994 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.026737e-03 2.989 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.091321e-03 2.962 0 0
Muscle contraction R-HSA-397014 1.207229e-03 2.918 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.419514e-03 2.848 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.419514e-03 2.848 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.419514e-03 2.848 0 0
Signaling by APC mutants R-HSA-4839744 1.419514e-03 2.848 0 0
Membrane Trafficking R-HSA-199991 1.474771e-03 2.831 0 0
Metabolism of RNA R-HSA-8953854 1.434252e-03 2.843 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.546171e-03 2.811 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.604139e-03 2.795 0 0
Post NMDA receptor activation events R-HSA-438064 1.630838e-03 2.788 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.913128e-03 2.718 0 0
Signaling by AXIN mutants R-HSA-4839735 1.913128e-03 2.718 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.958920e-03 2.708 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.972264e-03 2.705 0 0
Neurodegenerative Diseases R-HSA-8863678 1.972264e-03 2.705 0 0
Cellular responses to stimuli R-HSA-8953897 1.988272e-03 2.702 1 0
Integrin signaling R-HSA-354192 2.145422e-03 2.668 0 0
Apoptosis R-HSA-109581 2.147518e-03 2.668 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.145422e-03 2.668 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.267014e-03 2.645 0 0
Signaling by ERBB2 R-HSA-1227986 2.280249e-03 2.642 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.304468e-03 2.637 1 1
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.521780e-03 2.598 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.521780e-03 2.598 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.521780e-03 2.598 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.521780e-03 2.598 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.521780e-03 2.598 0 0
Ephrin signaling R-HSA-3928664 2.365911e-03 2.626 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.521780e-03 2.598 0 0
Macroautophagy R-HSA-1632852 2.461534e-03 2.609 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.365911e-03 2.626 0 0
Protein folding R-HSA-391251 2.801527e-03 2.553 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.901448e-03 2.537 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.967006e-03 2.528 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.996476e-03 2.523 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.804674e-03 2.552 0 0
EPH-Ephrin signaling R-HSA-2682334 2.801527e-03 2.553 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.033962e-03 2.518 0 0
MHC class II antigen presentation R-HSA-2132295 2.967006e-03 2.528 0 0
Signaling by SCF-KIT R-HSA-1433557 3.162848e-03 2.500 0 0
Autophagy R-HSA-9612973 3.180908e-03 2.497 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.323636e-03 2.478 0 0
Oncogene Induced Senescence R-HSA-2559585 3.349961e-03 2.475 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.547960e-03 2.450 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.655801e-03 2.437 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.655801e-03 2.437 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.738038e-03 2.427 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.341530e-03 2.362 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.049535e-03 2.393 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.239011e-03 2.373 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.986762e-03 2.399 0 0
Diseases of DNA repair R-HSA-9675135 4.560141e-03 2.341 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.851686e-03 2.314 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.065095e-03 2.295 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.120738e-03 2.291 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.182321e-03 2.285 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.182321e-03 2.285 0 0
p75NTR signals via NF-kB R-HSA-193639 5.182321e-03 2.285 0 0
DAP12 signaling R-HSA-2424491 5.287228e-03 2.277 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.391151e-03 2.268 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 5.391151e-03 2.268 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.074961e-03 2.216 0 0
Notch-HLH transcription pathway R-HSA-350054 6.074961e-03 2.216 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.777010e-03 2.238 0 0
Mitotic Prophase R-HSA-68875 5.522107e-03 2.258 0 0
Intraflagellar transport R-HSA-5620924 5.730603e-03 2.242 0 0
Signaling by KIT in disease R-HSA-9669938 6.074961e-03 2.216 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 6.083973e-03 2.216 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 6.083973e-03 2.216 0 0
Cellular Senescence R-HSA-2559583 6.552669e-03 2.184 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.698584e-03 2.174 0 0
Signaling by WNT in cancer R-HSA-4791275 7.010836e-03 2.154 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.102165e-03 2.149 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.152458e-03 2.146 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.270739e-03 2.138 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.402250e-03 2.131 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 7.973705e-03 2.098 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.014157e-03 2.096 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.710977e-03 2.013 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.710977e-03 2.013 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.124283e-03 2.040 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.143184e-03 2.039 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.908603e-03 2.004 0 0
Cellular response to chemical stress R-HSA-9711123 1.018011e-02 1.992 1 0
Polo-like kinase mediated events R-HSA-156711 1.120429e-02 1.951 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.120429e-02 1.951 0 0
Netrin-1 signaling R-HSA-373752 1.135357e-02 1.945 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.141388e-02 1.943 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.151940e-02 1.939 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.151940e-02 1.939 0 0
Signalling to ERKs R-HSA-187687 1.165874e-02 1.933 0 0
Death Receptor Signaling R-HSA-73887 1.212420e-02 1.916 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.223145e-02 1.913 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.286210e-02 1.891 0 0
RET signaling R-HSA-8853659 1.310388e-02 1.883 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 1.318280e-02 1.880 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.318280e-02 1.880 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.319646e-02 1.880 0 0
Signaling by MET R-HSA-6806834 1.425532e-02 1.846 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.426699e-02 1.846 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.426699e-02 1.846 0 0
MET activates RAS signaling R-HSA-8851805 1.426699e-02 1.846 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.558635e-02 1.807 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.558635e-02 1.807 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.652209e-02 1.782 0 0
Nef and signal transduction R-HSA-164944 1.558635e-02 1.807 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.528132e-02 1.816 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.666803e-02 1.778 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.691962e-02 1.772 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.695411e-02 1.771 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.739717e-02 1.760 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.739717e-02 1.760 0 0
RNA Polymerase II Transcription R-HSA-73857 1.747646e-02 1.758 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.766572e-02 1.753 0 0
Gene expression (Transcription) R-HSA-74160 1.774731e-02 1.751 0 0
Signalling to RAS R-HSA-167044 1.802839e-02 1.744 0 0
Signaling by ALK R-HSA-201556 1.820582e-02 1.740 0 0
G2/M Checkpoints R-HSA-69481 1.925531e-02 1.715 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.035165e-02 1.691 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.050820e-02 1.688 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.050820e-02 1.688 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.080142e-02 1.682 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.257371e-02 1.646 0 0
Diseases of cellular response to stress R-HSA-9675132 2.257371e-02 1.646 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.257371e-02 1.646 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.346855e-02 1.630 0 0
mRNA Splicing R-HSA-72172 2.149243e-02 1.668 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.485931e-02 1.605 0 0
DCC mediated attractive signaling R-HSA-418885 2.485931e-02 1.605 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.346855e-02 1.630 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.190218e-02 1.660 0 0
Semaphorin interactions R-HSA-373755 2.323266e-02 1.634 0 0
Programmed Cell Death R-HSA-5357801 2.241092e-02 1.650 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.229661e-02 1.652 0 0
Hemostasis R-HSA-109582 2.518518e-02 1.599 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.618627e-02 1.582 0 0
Co-stimulation by ICOS R-HSA-9927354 2.618627e-02 1.582 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.646696e-02 1.577 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.646696e-02 1.577 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.698264e-02 1.569 0 0
MTOR signalling R-HSA-165159 2.698264e-02 1.569 0 0
Translation initiation complex formation R-HSA-72649 2.859721e-02 1.544 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.921169e-02 1.534 0 0
Killing mechanisms R-HSA-9664420 2.921169e-02 1.534 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.921169e-02 1.534 0 0
Signaling by FGFR4 R-HSA-5654743 2.955940e-02 1.529 0 0
Generic Transcription Pathway R-HSA-212436 2.966341e-02 1.528 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.397985e-02 1.469 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.397985e-02 1.469 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.255491e-02 1.487 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.255491e-02 1.487 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.348929e-02 1.475 0 0
Signaling by EGFR R-HSA-177929 3.348929e-02 1.475 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.261860e-02 1.487 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.261860e-02 1.487 0 0
RAF activation R-HSA-5673000 3.255491e-02 1.487 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.591308e-02 1.445 0 0
NRAGE signals death through JNK R-HSA-193648 3.348929e-02 1.475 0 0
Signaling by FGFR2 R-HSA-5654738 3.304689e-02 1.481 0 0
Signaling by FGFR3 R-HSA-5654741 3.519914e-02 1.453 0 0
DAP12 interactions R-HSA-2172127 3.229708e-02 1.491 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.460774e-02 1.461 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.162630e-02 1.500 0 0
Interleukin-7 signaling R-HSA-1266695 3.460774e-02 1.461 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.623740e-02 1.441 0 0
rRNA processing R-HSA-72312 3.708340e-02 1.431 0 0
Metalloprotease DUBs R-HSA-5689901 3.876837e-02 1.412 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.892095e-02 1.410 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.919097e-02 1.407 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.919097e-02 1.407 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.933618e-02 1.405 1 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.979569e-02 1.400 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.979569e-02 1.400 0 0
Signal attenuation R-HSA-74749 3.979569e-02 1.400 0 0
PI3K/AKT activation R-HSA-198203 3.979569e-02 1.400 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.026141e-02 1.395 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.026141e-02 1.395 0 0
Vesicle-mediated transport R-HSA-5653656 4.075616e-02 1.390 0 0
Chromatin organization R-HSA-4839726 4.077952e-02 1.390 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.150882e-02 1.382 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.322121e-02 1.364 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.482331e-02 1.348 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.482331e-02 1.348 0 0
Tie2 Signaling R-HSA-210993 4.482331e-02 1.348 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.482331e-02 1.348 0 0
Defective OGG1 Localization R-HSA-9657050 5.570843e-02 1.254 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 5.570843e-02 1.254 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 5.570843e-02 1.254 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 5.570843e-02 1.254 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 5.570843e-02 1.254 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.714802e-02 1.327 0 0
Regulation of gap junction activity R-HSA-191650 4.714802e-02 1.327 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.714802e-02 1.327 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.770166e-02 1.321 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.770166e-02 1.321 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.631526e-02 1.249 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.088395e-02 1.293 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.088395e-02 1.293 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.125284e-02 1.290 0 0
MET promotes cell motility R-HSA-8875878 4.728754e-02 1.325 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.846120e-02 1.315 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.728754e-02 1.325 0 0
Activation of RAC1 R-HSA-428540 5.631526e-02 1.249 0 0
NF-kB is activated and signals survival R-HSA-209560 5.631526e-02 1.249 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.498157e-02 1.260 0 0
Cardiac conduction R-HSA-5576891 4.774357e-02 1.321 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.152117e-02 1.288 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.631526e-02 1.249 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.811427e-02 1.318 0 0
Developmental Biology R-HSA-1266738 4.878310e-02 1.312 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.301249e-02 1.276 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.796876e-02 1.319 0 0
PECAM1 interactions R-HSA-210990 4.770166e-02 1.321 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.737008e-02 1.241 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.737008e-02 1.241 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.737008e-02 1.241 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.737008e-02 1.241 0 0
Nephrin family interactions R-HSA-373753 5.737008e-02 1.241 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.835289e-02 1.234 0 0
IGF1R signaling cascade R-HSA-2428924 5.863336e-02 1.232 0 0
Ion transport by P-type ATPases R-HSA-936837 5.863336e-02 1.232 0 0
Hedgehog 'off' state R-HSA-5610787 5.879500e-02 1.231 0 0
Signaling by Interleukins R-HSA-449147 6.000112e-02 1.222 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.184695e-02 1.209 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.184695e-02 1.209 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.184695e-02 1.209 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.184695e-02 1.209 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.184695e-02 1.209 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.243473e-02 1.205 0 0
PCP/CE pathway R-HSA-4086400 6.306819e-02 1.200 0 0
Downstream signal transduction R-HSA-186763 6.398946e-02 1.194 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.427694e-02 1.192 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.427694e-02 1.192 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.427694e-02 1.192 0 0
Smooth Muscle Contraction R-HSA-445355 6.464783e-02 1.189 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.557030e-02 1.183 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.561078e-02 1.183 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.561078e-02 1.183 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.561078e-02 1.183 0 0
Disorders of Nervous System Development R-HSA-9697154 6.561078e-02 1.183 0 0
Pervasive developmental disorders R-HSA-9005895 6.561078e-02 1.183 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.561078e-02 1.183 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.561078e-02 1.183 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.609322e-02 1.180 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.159792e-02 1.145 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.245453e-02 1.140 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.435470e-02 1.129 0 0
HCMV Early Events R-HSA-9609690 7.484219e-02 1.126 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.786560e-02 1.109 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.786560e-02 1.109 0 0
Phosphorylation of Emi1 R-HSA-176417 7.786560e-02 1.109 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 9.501168e-02 1.022 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.555887e-02 1.122 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.612726e-02 1.065 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.612726e-02 1.065 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.728142e-02 1.012 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.932472e-02 1.101 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.744753e-02 1.058 0 0
Deadenylation of mRNA R-HSA-429947 9.595511e-02 1.018 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.614448e-02 1.118 0 0
Striated Muscle Contraction R-HSA-390522 8.265739e-02 1.083 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.265739e-02 1.083 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.653383e-02 1.015 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.060946e-02 1.094 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.231351e-02 1.085 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.265739e-02 1.083 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.427907e-02 1.026 0 0
mTORC1-mediated signalling R-HSA-166208 7.932472e-02 1.101 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.612726e-02 1.065 0 0
Mitophagy R-HSA-5205647 8.945544e-02 1.048 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.786560e-02 1.109 0 0
Homology Directed Repair R-HSA-5693538 8.231351e-02 1.085 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.614448e-02 1.118 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.984577e-02 1.001 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.984577e-02 1.001 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.984577e-02 1.001 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.984577e-02 1.001 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.786560e-02 1.109 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.728142e-02 1.012 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.728142e-02 1.012 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.614448e-02 1.118 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.467977e-02 1.024 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.786560e-02 1.109 0 0
Signaling by FGFR1 R-HSA-5654736 7.865015e-02 1.104 0 0
Signal regulatory protein family interactions R-HSA-391160 8.612726e-02 1.065 0 0
p38MAPK events R-HSA-171007 9.728142e-02 1.012 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.984577e-02 1.001 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.164590e-02 1.088 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.786560e-02 1.109 0 0
Syndecan interactions R-HSA-3000170 8.744753e-02 1.058 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.984577e-02 1.001 0 0
MAPK family signaling cascades R-HSA-5683057 8.138254e-02 1.089 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.728142e-02 1.012 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.945544e-02 1.048 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.841555e-02 1.053 0 0
Diseases of Base Excision Repair R-HSA-9605308 7.786560e-02 1.109 0 0
Signaling by LTK in cancer R-HSA-9842640 9.501168e-02 1.022 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.786560e-02 1.109 0 0
Chromatin modifying enzymes R-HSA-3247509 9.991018e-02 1.000 0 0
Signaling by FGFR R-HSA-190236 1.013076e-01 0.994 0 0
S Phase R-HSA-69242 1.016637e-01 0.993 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.034425e-01 0.985 0 0
FLT3 signaling in disease R-HSA-9682385 1.038870e-01 0.983 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.038870e-01 0.983 0 0
RUNX2 regulates bone development R-HSA-8941326 1.038870e-01 0.983 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.048350e-01 0.979 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.048350e-01 0.979 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 1.083166e-01 0.965 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.083166e-01 0.965 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.083166e-01 0.965 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.083166e-01 0.965 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.083166e-01 0.965 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.083166e-01 0.965 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.083166e-01 0.965 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.083166e-01 0.965 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.083166e-01 0.965 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.083166e-01 0.965 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.083166e-01 0.965 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.083166e-01 0.965 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.083166e-01 0.965 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.083166e-01 0.965 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.083166e-01 0.965 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.579969e-01 0.801 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.579969e-01 0.801 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.579969e-01 0.801 0 0
Defective VWF binding to collagen type I R-HSA-9845622 1.579969e-01 0.801 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.579969e-01 0.801 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.579969e-01 0.801 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.579969e-01 0.801 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.579969e-01 0.801 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.579969e-01 0.801 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.579969e-01 0.801 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.579969e-01 0.801 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.579969e-01 0.801 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.579969e-01 0.801 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.131102e-01 0.946 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 1.131102e-01 0.946 0 0
SOS-mediated signalling R-HSA-112412 1.131102e-01 0.946 0 0
Recycling of eIF2:GDP R-HSA-72731 1.131102e-01 0.946 0 0
Disinhibition of SNARE formation R-HSA-114516 1.131102e-01 0.946 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.320020e-01 0.879 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.320020e-01 0.879 0 0
MET receptor recycling R-HSA-8875656 1.320020e-01 0.879 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.515428e-01 0.819 0 0
ARMS-mediated activation R-HSA-170984 1.515428e-01 0.819 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.515428e-01 0.819 0 0
WNT mediated activation of DVL R-HSA-201688 1.515428e-01 0.819 0 0
ALK mutants bind TKIs R-HSA-9700645 1.515428e-01 0.819 1 1
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.089851e-01 0.963 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.338903e-01 0.873 0 0
GAB1 signalosome R-HSA-180292 1.470150e-01 0.833 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.140736e-01 0.943 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.335677e-01 0.874 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.275292e-01 0.894 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.359126e-01 0.867 0 0
Degradation of CDH1 R-HSA-9766229 1.128424e-01 0.948 0 0
mRNA 3'-end processing R-HSA-72187 1.340697e-01 0.873 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.340697e-01 0.873 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.415379e-01 0.849 0 0
Activation of the pre-replicative complex R-HSA-68962 1.543116e-01 0.812 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.543116e-01 0.812 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.437917e-01 0.842 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.089851e-01 0.963 0 0
DNA Double Strand Break Response R-HSA-5693606 1.436043e-01 0.843 0 0
Myogenesis R-HSA-525793 1.140736e-01 0.943 0 0
Disorders of Developmental Biology R-HSA-9675151 1.212008e-01 0.916 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.131102e-01 0.946 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 1.515428e-01 0.819 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.089851e-01 0.963 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.142011e-01 0.942 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.470150e-01 0.833 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.335677e-01 0.874 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.437917e-01 0.842 0 0
RNA Polymerase I Transcription R-HSA-73864 1.255388e-01 0.901 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.141872e-01 0.942 0 0
Netrin mediated repulsion signals R-HSA-418886 1.131102e-01 0.946 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.320020e-01 0.879 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.236563e-01 0.908 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 1.338903e-01 0.873 0 0
Parasite infection R-HSA-9664407 1.230838e-01 0.910 0 0
Leishmania phagocytosis R-HSA-9664417 1.230838e-01 0.910 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.230838e-01 0.910 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.515428e-01 0.819 0 0
Cell-Cell communication R-HSA-1500931 1.162316e-01 0.935 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.083166e-01 0.965 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 1.579969e-01 0.801 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.128424e-01 0.948 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.436043e-01 0.843 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.298492e-01 0.887 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.445335e-01 0.840 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.360586e-01 0.866 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.437917e-01 0.842 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.543116e-01 0.812 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.140736e-01 0.943 0 0
DNA Repair R-HSA-73894 1.530277e-01 0.815 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.579969e-01 0.801 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.131102e-01 0.946 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.320020e-01 0.879 0 0
Unwinding of DNA R-HSA-176974 1.515428e-01 0.819 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.470150e-01 0.833 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.437917e-01 0.842 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.437917e-01 0.842 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.298492e-01 0.887 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.097919e-01 0.959 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 1.515428e-01 0.819 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.515428e-01 0.819 0 0
FLT3 Signaling R-HSA-9607240 1.445335e-01 0.840 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.515428e-01 0.819 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.140736e-01 0.943 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.515428e-01 0.819 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.087486e-01 0.964 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.515428e-01 0.819 0 0
Apoptotic factor-mediated response R-HSA-111471 1.470150e-01 0.833 0 0
Signaling by ROBO receptors R-HSA-376176 1.438248e-01 0.842 0 0
MAP kinase activation R-HSA-450294 1.055884e-01 0.976 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.579969e-01 0.801 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.131102e-01 0.946 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.089851e-01 0.963 0 0
Signaling by PTK6 R-HSA-8848021 1.175929e-01 0.930 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.175929e-01 0.930 0 0
Interleukin-2 family signaling R-HSA-451927 1.359126e-01 0.867 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.275292e-01 0.894 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.515428e-01 0.819 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.236563e-01 0.908 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.340697e-01 0.873 0 0
Interferon Signaling R-HSA-913531 1.317227e-01 0.880 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.250460e-01 0.903 0 0
Platelet sensitization by LDL R-HSA-432142 1.470150e-01 0.833 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.605361e-01 0.794 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.605361e-01 0.794 0 0
Other interleukin signaling R-HSA-449836 1.605361e-01 0.794 0 0
Interleukin-17 signaling R-HSA-448424 1.647605e-01 0.783 0 0
Ion homeostasis R-HSA-5578775 1.650451e-01 0.782 0 0
Meiosis R-HSA-1500620 1.695345e-01 0.771 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.695345e-01 0.771 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.049120e-01 0.688 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.049120e-01 0.688 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.049120e-01 0.688 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.049120e-01 0.688 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.049120e-01 0.688 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.049120e-01 0.688 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.049120e-01 0.688 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.049120e-01 0.688 0 0
Axonal growth stimulation R-HSA-209563 2.492158e-01 0.603 0 0
Classical Kir channels R-HSA-1296053 2.492158e-01 0.603 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 2.492158e-01 0.603 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 2.492158e-01 0.603 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 2.492158e-01 0.603 0 0
MET activates PTPN11 R-HSA-8865999 2.492158e-01 0.603 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.910535e-01 0.536 0 0
Nucleotide catabolism defects R-HSA-9735786 2.910535e-01 0.536 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.910535e-01 0.536 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.910535e-01 0.536 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 2.910535e-01 0.536 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.716020e-01 0.765 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.716020e-01 0.765 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.716020e-01 0.765 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.716020e-01 0.765 0 0
IRS activation R-HSA-74713 3.305621e-01 0.481 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.305621e-01 0.481 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.305621e-01 0.481 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.305621e-01 0.481 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.305621e-01 0.481 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.305621e-01 0.481 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.128138e-01 0.672 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.337638e-01 0.631 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.337638e-01 0.631 0 0
Formation of definitive endoderm R-HSA-9823730 1.744153e-01 0.758 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.886144e-01 0.724 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.886144e-01 0.724 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.030962e-01 0.692 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.030962e-01 0.692 0 0
FGFR2 alternative splicing R-HSA-6803529 2.178243e-01 0.662 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.969792e-01 0.527 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.327630e-01 0.633 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.327630e-01 0.633 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.990000e-01 0.701 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.478783e-01 0.606 0 0
Phosphorylation of the APC/C R-HSA-176412 3.179420e-01 0.498 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.179420e-01 0.498 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.179420e-01 0.498 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.387535e-01 0.470 0 0
Phase 2 - plateau phase R-HSA-5576893 3.387535e-01 0.470 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.387535e-01 0.470 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.007155e-01 0.697 0 0
Regulation of CDH1 Function R-HSA-9764561 1.732284e-01 0.761 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.939582e-01 0.532 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.939582e-01 0.532 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.939582e-01 0.532 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.939582e-01 0.532 0 0
Metabolism of non-coding RNA R-HSA-194441 1.900779e-01 0.721 0 0
snRNP Assembly R-HSA-191859 1.900779e-01 0.721 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.987306e-01 0.702 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.094615e-01 0.509 0 0
HIV elongation arrest and recovery R-HSA-167287 3.094615e-01 0.509 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.094615e-01 0.509 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.094615e-01 0.509 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.094615e-01 0.509 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.718805e-01 0.566 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.844801e-01 0.546 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.844801e-01 0.546 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.629143e-01 0.580 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.405155e-01 0.468 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.405155e-01 0.468 0 0
Meiotic synapsis R-HSA-1221632 2.737003e-01 0.563 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.099129e-01 0.509 0 0
HIV Transcription Initiation R-HSA-167161 3.099129e-01 0.509 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.099129e-01 0.509 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.227137e-01 0.491 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.270339e-01 0.644 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.355498e-01 0.474 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.821345e-01 0.550 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.581188e-01 0.588 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.660886e-01 0.575 0 0
Signaling by NOTCH4 R-HSA-9013694 3.314484e-01 0.480 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.845696e-01 0.546 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.845696e-01 0.546 0 0
Transcription of the HIV genome R-HSA-167172 2.724660e-01 0.565 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.050654e-01 0.688 0 0
HIV Transcription Elongation R-HSA-167169 2.844801e-01 0.546 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.548248e-01 0.594 0 0
mRNA Capping R-HSA-72086 3.249893e-01 0.488 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.405155e-01 0.468 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.548248e-01 0.594 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.844801e-01 0.546 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.721057e-01 0.764 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.001538e-01 0.523 0 0
Regulation of CDH11 function R-HSA-9762292 1.716020e-01 0.765 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.178243e-01 0.662 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.718805e-01 0.566 0 0
Attenuation phase R-HSA-3371568 2.844801e-01 0.546 0 0
Eukaryotic Translation Termination R-HSA-72764 2.660886e-01 0.575 0 0
Peptide chain elongation R-HSA-156902 3.231884e-01 0.491 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.107347e-01 0.676 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.478783e-01 0.606 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.405155e-01 0.468 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.065574e-01 0.513 0 0
Erythropoietin activates RAS R-HSA-9027284 2.969792e-01 0.527 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.327630e-01 0.633 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.844801e-01 0.546 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.761696e-01 0.754 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.874723e-01 0.727 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.910535e-01 0.536 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.716020e-01 0.765 0 0
Formation of the posterior neural plate R-HSA-9832991 1.920612e-01 0.717 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 3.305621e-01 0.481 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.548248e-01 0.594 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.759197e-01 0.559 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.387535e-01 0.470 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.844801e-01 0.546 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.844801e-01 0.546 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.387535e-01 0.470 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.969792e-01 0.527 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.990000e-01 0.701 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.785070e-01 0.555 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.387535e-01 0.470 0 0
HDACs deacetylate histones R-HSA-3214815 2.955326e-01 0.529 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.874723e-01 0.727 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.631369e-01 0.580 0 0
Neurexins and neuroligins R-HSA-6794361 2.629143e-01 0.580 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.099129e-01 0.509 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.016884e-01 0.520 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.226582e-01 0.652 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.918778e-01 0.535 0 0
HCMV Infection R-HSA-9609646 2.915039e-01 0.535 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.226582e-01 0.652 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 2.049120e-01 0.688 0 0
MET interacts with TNS proteins R-HSA-8875513 2.492158e-01 0.603 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.910535e-01 0.536 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.910535e-01 0.536 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.910535e-01 0.536 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.305621e-01 0.481 0 0
ERKs are inactivated R-HSA-202670 2.128138e-01 0.672 0 0
Signaling by NOTCH2 R-HSA-1980145 2.107347e-01 0.676 0 0
Fibronectin matrix formation R-HSA-1566977 3.387535e-01 0.470 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.399395e-01 0.469 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.874723e-01 0.727 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.874723e-01 0.727 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.716020e-01 0.765 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.744153e-01 0.758 0 0
ESR-mediated signaling R-HSA-8939211 2.272658e-01 0.643 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.904050e-01 0.537 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.904050e-01 0.537 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.904050e-01 0.537 0 0
NGF-stimulated transcription R-HSA-9031628 2.208953e-01 0.656 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.723643e-01 0.764 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.305621e-01 0.481 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.969792e-01 0.527 0 0
Signaling by Erythropoietin R-HSA-9006335 3.249893e-01 0.488 0 0
Signaling by WNT R-HSA-195721 2.861857e-01 0.543 0 0
Host Interactions of HIV factors R-HSA-162909 2.716908e-01 0.566 0 0
Pexophagy R-HSA-9664873 1.716020e-01 0.765 0 0
Signaling by NOTCH1 R-HSA-1980143 2.108262e-01 0.676 0 0
Signaling by Hedgehog R-HSA-5358351 2.797582e-01 0.553 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.795428e-01 0.746 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.478783e-01 0.606 0 0
Interleukin-15 signaling R-HSA-8983432 2.337638e-01 0.631 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.194826e-01 0.659 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.065574e-01 0.513 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.066518e-01 0.685 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.492158e-01 0.603 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.492158e-01 0.603 0 0
NADE modulates death signalling R-HSA-205025 2.910535e-01 0.536 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.920612e-01 0.717 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.305621e-01 0.481 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.128138e-01 0.672 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.759197e-01 0.559 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.969792e-01 0.527 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.179420e-01 0.498 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.795902e-01 0.746 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.629143e-01 0.580 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.983286e-01 0.703 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.413401e-01 0.617 0 0
Reproduction R-HSA-1474165 3.296490e-01 0.482 0 0
Prolonged ERK activation events R-HSA-169893 3.179420e-01 0.498 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.795902e-01 0.746 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.694777e-01 0.569 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.115587e-01 0.506 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.694777e-01 0.569 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.329066e-01 0.633 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.030962e-01 0.692 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.214812e-01 0.493 0 0
Pyroptosis R-HSA-5620971 3.094615e-01 0.509 0 0
Signaling by ERBB4 R-HSA-1236394 3.314484e-01 0.480 0 0
Histamine receptors R-HSA-390650 2.492158e-01 0.603 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.724660e-01 0.565 0 0
G1/S Transition R-HSA-69206 2.858997e-01 0.544 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.387535e-01 0.470 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.164564e-01 0.665 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.492158e-01 0.603 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.910535e-01 0.536 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 2.910535e-01 0.536 0 0
Reelin signalling pathway R-HSA-8866376 3.305621e-01 0.481 0 0
Co-inhibition by BTLA R-HSA-9927353 3.305621e-01 0.481 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.305621e-01 0.481 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.548248e-01 0.594 0 0
TGFBR3 expression R-HSA-9839394 2.631369e-01 0.580 0 0
Passive transport by Aquaporins R-HSA-432047 3.387535e-01 0.470 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.075258e-01 0.683 0 0
FOXO-mediated transcription R-HSA-9614085 2.986314e-01 0.525 0 0
Diseases of programmed cell death R-HSA-9645723 1.974217e-01 0.705 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.365930e-01 0.626 0 0
Glycogen metabolism R-HSA-8982491 2.844801e-01 0.546 0 0
Integrin cell surface interactions R-HSA-216083 2.271527e-01 0.644 0 0
Glycolysis R-HSA-70171 3.069108e-01 0.513 0 0
Neuronal System R-HSA-112316 1.931667e-01 0.714 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.305621e-01 0.481 0 0
Formation of the anterior neural plate R-HSA-9823739 2.969792e-01 0.527 0 0
PTEN Regulation R-HSA-6807070 2.865107e-01 0.543 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.346943e-01 0.629 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.063999e-01 0.685 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.065574e-01 0.513 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.629143e-01 0.580 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.400746e-01 0.620 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.920612e-01 0.717 0 0
P2Y receptors R-HSA-417957 2.759197e-01 0.559 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.305621e-01 0.481 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.305621e-01 0.481 0 0
Platelet calcium homeostasis R-HSA-418360 3.249893e-01 0.488 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.593812e-01 0.586 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.107347e-01 0.676 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.832477e-01 0.737 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.865107e-01 0.543 1 0
IRE1alpha activates chaperones R-HSA-381070 2.270339e-01 0.644 0 0
HIV Infection R-HSA-162906 3.456655e-01 0.461 0 0
Cyclin D associated events in G1 R-HSA-69231 3.484062e-01 0.458 0 0
G1 Phase R-HSA-69236 3.484062e-01 0.458 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.505801e-01 0.455 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 3.511352e-01 0.455 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.520070e-01 0.453 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.548205e-01 0.450 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.548205e-01 0.450 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.548205e-01 0.450 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.560153e-01 0.449 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.560153e-01 0.449 0 0
EGFR downregulation R-HSA-182971 3.560153e-01 0.449 0 0
Trafficking of AMPA receptors R-HSA-399719 3.560153e-01 0.449 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.593656e-01 0.444 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.593656e-01 0.444 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.593656e-01 0.444 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.593656e-01 0.444 0 0
Specification of primordial germ cells R-HSA-9827857 3.593656e-01 0.444 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.612682e-01 0.442 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.612682e-01 0.442 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.612682e-01 0.442 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.623487e-01 0.441 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.678712e-01 0.434 0 0
Plus-strand DNA synthesis R-HSA-164525 3.678712e-01 0.434 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.678712e-01 0.434 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.678712e-01 0.434 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.678712e-01 0.434 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.678712e-01 0.434 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 3.678712e-01 0.434 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.678712e-01 0.434 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.678712e-01 0.434 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 3.678712e-01 0.434 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.678712e-01 0.434 0 0
VEGF ligand-receptor interactions R-HSA-194313 3.678712e-01 0.434 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.678712e-01 0.434 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.678712e-01 0.434 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.678712e-01 0.434 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.678712e-01 0.434 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.689772e-01 0.433 0 0
Potential therapeutics for SARS R-HSA-9679191 3.704729e-01 0.431 0 0
Cellular response to heat stress R-HSA-3371556 3.707795e-01 0.431 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.714656e-01 0.430 0 0
G alpha (12/13) signalling events R-HSA-416482 3.716184e-01 0.430 0 0
Heme signaling R-HSA-9707616 3.735702e-01 0.428 0 0
tRNA processing in the nucleus R-HSA-6784531 3.735702e-01 0.428 0 0
Signaling by PDGF R-HSA-186797 3.735702e-01 0.428 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.741218e-01 0.427 0 0
Signaling by TGFBR3 R-HSA-9839373 3.741218e-01 0.427 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.756267e-01 0.425 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.787850e-01 0.422 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.787850e-01 0.422 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.797358e-01 0.421 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.797358e-01 0.421 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 3.797358e-01 0.421 0 0
Sensory processing of sound R-HSA-9659379 3.817007e-01 0.418 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.817007e-01 0.418 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.830787e-01 0.417 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.868445e-01 0.412 0 0
Nuclear RNA decay R-HSA-9930044 3.868445e-01 0.412 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.868445e-01 0.412 0 0
G-protein beta:gamma signalling R-HSA-397795 3.868445e-01 0.412 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.869536e-01 0.412 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.916454e-01 0.407 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.917853e-01 0.407 0 0
Insulin receptor signalling cascade R-HSA-74751 3.960004e-01 0.402 0 0
GPER1 signaling R-HSA-9634597 3.997506e-01 0.398 0 0
Translesion Synthesis by POLH R-HSA-110320 3.998273e-01 0.398 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.998273e-01 0.398 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.998273e-01 0.398 0 0
Crosslinking of collagen fibrils R-HSA-2243919 3.998273e-01 0.398 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.998273e-01 0.398 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.998273e-01 0.398 0 0
Rap1 signalling R-HSA-392517 3.998273e-01 0.398 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.018654e-01 0.396 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.021317e-01 0.396 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.021317e-01 0.396 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.021317e-01 0.396 0 0
STAT5 Activation R-HSA-9645135 4.031031e-01 0.395 0 0
Uncoating of the HIV Virion R-HSA-162585 4.031031e-01 0.395 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.031031e-01 0.395 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 4.031031e-01 0.395 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 4.031031e-01 0.395 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.031031e-01 0.395 0 0
NADPH regeneration R-HSA-389542 4.031031e-01 0.395 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.031031e-01 0.395 0 0
Leukotriene receptors R-HSA-391906 4.031031e-01 0.395 0 0
Lipid particle organization R-HSA-8964572 4.031031e-01 0.395 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.064070e-01 0.391 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.071912e-01 0.390 0 0
DNA Damage Bypass R-HSA-73893 4.125003e-01 0.385 0 0
Potassium Channels R-HSA-1296071 4.151334e-01 0.382 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.173082e-01 0.380 0 0
Nuclear import of Rev protein R-HSA-180746 4.173082e-01 0.380 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.196078e-01 0.377 0 0
Negative regulation of MET activity R-HSA-6807004 4.196078e-01 0.377 0 0
Signal transduction by L1 R-HSA-445144 4.196078e-01 0.377 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.196078e-01 0.377 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.196078e-01 0.377 0 0
Signaling by NOTCH R-HSA-157118 4.218724e-01 0.375 0 0
Adaptive Immune System R-HSA-1280218 4.223181e-01 0.374 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.243516e-01 0.372 0 0
PI3K Cascade R-HSA-109704 4.251911e-01 0.371 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.259232e-01 0.371 0 0
PERK regulates gene expression R-HSA-381042 4.323563e-01 0.364 1 1
Late Phase of HIV Life Cycle R-HSA-162599 4.352164e-01 0.361 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 4.363733e-01 0.360 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.363733e-01 0.360 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.363733e-01 0.360 0 0
PTK6 Expression R-HSA-8849473 4.363733e-01 0.360 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.363733e-01 0.360 0 0
VLDL clearance R-HSA-8964046 4.363733e-01 0.360 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.363733e-01 0.360 0 0
Regulation of PTEN localization R-HSA-8948747 4.363733e-01 0.360 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.363733e-01 0.360 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.363733e-01 0.360 0 0
HSF1-dependent transactivation R-HSA-3371571 4.378116e-01 0.359 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.390495e-01 0.357 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.390495e-01 0.357 0 0
ERK/MAPK targets R-HSA-198753 4.390495e-01 0.357 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.420147e-01 0.355 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.420147e-01 0.355 0 0
Cell junction organization R-HSA-446728 4.438379e-01 0.353 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.472599e-01 0.349 0 0
RNA Polymerase III Transcription R-HSA-74158 4.472599e-01 0.349 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.472599e-01 0.349 0 0
HSF1 activation R-HSA-3371511 4.472599e-01 0.349 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.503513e-01 0.346 0 0
Orc1 removal from chromatin R-HSA-68949 4.503513e-01 0.346 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.515320e-01 0.345 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.581290e-01 0.339 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.581290e-01 0.339 0 0
Parasitic Infection Pathways R-HSA-9824443 4.605372e-01 0.337 0 0
Leishmania infection R-HSA-9658195 4.605372e-01 0.337 0 0
Selenocysteine synthesis R-HSA-2408557 4.610208e-01 0.336 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.619027e-01 0.335 0 0
Voltage gated Potassium channels R-HSA-1296072 4.620037e-01 0.335 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.620037e-01 0.335 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.620037e-01 0.335 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.620037e-01 0.335 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.620037e-01 0.335 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.620037e-01 0.335 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.625711e-01 0.335 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.625711e-01 0.335 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.625711e-01 0.335 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.627999e-01 0.335 0 0
Adipogenesis R-HSA-9843745 4.669428e-01 0.331 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.677910e-01 0.330 0 0
Minus-strand DNA synthesis R-HSA-164516 4.677910e-01 0.330 0 0
Formation of annular gap junctions R-HSA-196025 4.677910e-01 0.330 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.677910e-01 0.330 0 0
Activation of RAS in B cells R-HSA-1169092 4.677910e-01 0.330 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.677910e-01 0.330 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.677910e-01 0.330 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.677910e-01 0.330 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.677910e-01 0.330 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.677910e-01 0.330 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.701146e-01 0.328 0 0
PI Metabolism R-HSA-1483255 4.701146e-01 0.328 0 0
Selenoamino acid metabolism R-HSA-2408522 4.711438e-01 0.327 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.765743e-01 0.322 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.768261e-01 0.322 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 4.768261e-01 0.322 0 0
LDL clearance R-HSA-8964038 4.768261e-01 0.322 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.768261e-01 0.322 0 0
Glucose metabolism R-HSA-70326 4.769432e-01 0.322 0 0
Viral mRNA Translation R-HSA-192823 4.791704e-01 0.320 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.804530e-01 0.318 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.843146e-01 0.315 0 0
Signaling by NOTCH3 R-HSA-9012852 4.873869e-01 0.312 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.881841e-01 0.311 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.909588e-01 0.309 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.951242e-01 0.305 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.951242e-01 0.305 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.951242e-01 0.305 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.971518e-01 0.304 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.971518e-01 0.304 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.974593e-01 0.303 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.974593e-01 0.303 0 0
Gap junction degradation R-HSA-190873 4.974593e-01 0.303 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.974593e-01 0.303 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.974593e-01 0.303 0 0
Calcineurin activates NFAT R-HSA-2025928 4.974593e-01 0.303 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.974593e-01 0.303 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.974593e-01 0.303 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.974593e-01 0.303 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.974593e-01 0.303 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.974593e-01 0.303 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.974593e-01 0.303 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.974593e-01 0.303 0 0
Adherens junctions interactions R-HSA-418990 4.976707e-01 0.303 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.995079e-01 0.301 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.051461e-01 0.297 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.051461e-01 0.297 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.051461e-01 0.297 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.051461e-01 0.297 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.051461e-01 0.297 0 0
Signaling by FGFR in disease R-HSA-1226099 5.057435e-01 0.296 0 0
IRS-mediated signalling R-HSA-112399 5.115032e-01 0.291 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.115032e-01 0.291 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.130098e-01 0.290 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.130098e-01 0.290 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.130098e-01 0.290 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.130098e-01 0.290 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.141397e-01 0.289 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.141397e-01 0.289 0 0
Integration of energy metabolism R-HSA-163685 5.141397e-01 0.289 0 0
Platelet homeostasis R-HSA-418346 5.149340e-01 0.288 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.191257e-01 0.285 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.191257e-01 0.285 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.237413e-01 0.281 0 0
Binding and entry of HIV virion R-HSA-173107 5.254753e-01 0.279 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.254753e-01 0.279 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 5.254753e-01 0.279 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.254753e-01 0.279 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.254753e-01 0.279 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.254753e-01 0.279 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.254753e-01 0.279 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.254753e-01 0.279 0 0
Signaling by Leptin R-HSA-2586552 5.254753e-01 0.279 0 0
Ribosome-associated quality control R-HSA-9948299 5.295882e-01 0.276 0 0
Signaling by Insulin receptor R-HSA-74752 5.298011e-01 0.276 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.304719e-01 0.275 0 0
Hyaluronan degradation R-HSA-2160916 5.304719e-01 0.275 0 0
HDMs demethylate histones R-HSA-3214842 5.304719e-01 0.275 0 0
Formation of the nephric duct R-HSA-9830364 5.304719e-01 0.275 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.328885e-01 0.273 0 0
MAP2K and MAPK activation R-HSA-5674135 5.328885e-01 0.273 0 0
Intra-Golgi traffic R-HSA-6811438 5.328885e-01 0.273 0 0
Regulation of beta-cell development R-HSA-186712 5.350883e-01 0.272 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.392215e-01 0.268 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.414464e-01 0.266 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.414464e-01 0.266 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.464263e-01 0.262 0 0
HIV Life Cycle R-HSA-162587 5.466131e-01 0.262 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.466650e-01 0.262 0 0
MET activates PTK2 signaling R-HSA-8874081 5.475022e-01 0.262 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.475022e-01 0.262 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.475022e-01 0.262 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.519311e-01 0.258 0 0
Synthesis of PI R-HSA-1483226 5.519311e-01 0.258 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.519311e-01 0.258 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.519311e-01 0.258 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.519311e-01 0.258 0 0
Suppression of apoptosis R-HSA-9635465 5.519311e-01 0.258 0 0
Interleukin-2 signaling R-HSA-9020558 5.519311e-01 0.258 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.519311e-01 0.258 0 0
Cellular response to starvation R-HSA-9711097 5.537794e-01 0.257 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.551330e-01 0.256 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.578119e-01 0.254 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.580899e-01 0.253 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.597318e-01 0.252 0 0
TBC/RABGAPs R-HSA-8854214 5.597318e-01 0.252 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.640946e-01 0.249 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.640946e-01 0.249 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.668080e-01 0.247 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.669749e-01 0.246 0 0
Platelet degranulation R-HSA-114608 5.669906e-01 0.246 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.676957e-01 0.246 0 0
Signaling by TGFB family members R-HSA-9006936 5.679777e-01 0.246 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.693579e-01 0.245 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.693579e-01 0.245 0 0
RMTs methylate histone arginines R-HSA-3214858 5.727987e-01 0.242 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.758442e-01 0.240 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.769134e-01 0.239 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.769134e-01 0.239 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.769134e-01 0.239 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.769134e-01 0.239 0 0
Scavenging by Class H Receptors R-HSA-3000497 5.769134e-01 0.239 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.769134e-01 0.239 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.769134e-01 0.239 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.769134e-01 0.239 0 0
Anchoring fibril formation R-HSA-2214320 5.769134e-01 0.239 0 0
Integration of provirus R-HSA-162592 5.769134e-01 0.239 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.769134e-01 0.239 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.804642e-01 0.236 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.804642e-01 0.236 0 0
Influenza Infection R-HSA-168255 5.820222e-01 0.235 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.835269e-01 0.234 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.856215e-01 0.232 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.856215e-01 0.232 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.856215e-01 0.232 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.856215e-01 0.232 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.874434e-01 0.231 0 0
Cell-cell junction organization R-HSA-421270 5.891411e-01 0.230 0 0
Transmission across Chemical Synapses R-HSA-112315 5.909986e-01 0.228 0 0
Late endosomal microautophagy R-HSA-9615710 5.959510e-01 0.225 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.959510e-01 0.225 0 0
DARPP-32 events R-HSA-180024 5.959510e-01 0.225 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.981958e-01 0.223 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.981958e-01 0.223 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.981958e-01 0.223 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.981958e-01 0.223 0 0
Signaling by RAS mutants R-HSA-6802949 5.981958e-01 0.223 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.981958e-01 0.223 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.005042e-01 0.221 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.005042e-01 0.221 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.005042e-01 0.221 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.005042e-01 0.221 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.005042e-01 0.221 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.005042e-01 0.221 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.005042e-01 0.221 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.005042e-01 0.221 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.005042e-01 0.221 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.005042e-01 0.221 0 0
OAS antiviral response R-HSA-8983711 6.005042e-01 0.221 0 0
HATs acetylate histones R-HSA-3214847 6.026716e-01 0.220 0 0
Viral Infection Pathways R-HSA-9824446 6.093382e-01 0.215 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.105175e-01 0.214 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.111958e-01 0.214 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.112121e-01 0.214 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.112121e-01 0.214 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.112121e-01 0.214 0 0
Activation of BH3-only proteins R-HSA-114452 6.112121e-01 0.214 0 0
Interleukin-37 signaling R-HSA-9008059 6.112121e-01 0.214 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.119808e-01 0.213 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.127713e-01 0.213 0 0
Gastrulation R-HSA-9758941 6.180150e-01 0.209 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.195877e-01 0.208 0 0
Formation of axial mesoderm R-HSA-9796292 6.227810e-01 0.206 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.227810e-01 0.206 0 0
Diseases of nucleotide metabolism R-HSA-9735804 6.227810e-01 0.206 0 0
Chylomicron remodeling R-HSA-8963901 6.227810e-01 0.206 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.227810e-01 0.206 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.227810e-01 0.206 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.227810e-01 0.206 0 0
Interleukin-6 signaling R-HSA-1059683 6.227810e-01 0.206 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.227810e-01 0.206 0 0
Mitochondrial biogenesis R-HSA-1592230 6.238786e-01 0.205 0 0
Rab regulation of trafficking R-HSA-9007101 6.238786e-01 0.205 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.260289e-01 0.203 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.260289e-01 0.203 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.260289e-01 0.203 0 0
Neutrophil degranulation R-HSA-6798695 6.336240e-01 0.198 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.404036e-01 0.194 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.404036e-01 0.194 0 0
DNA strand elongation R-HSA-69190 6.404036e-01 0.194 0 0
G0 and Early G1 R-HSA-1538133 6.404036e-01 0.194 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.438169e-01 0.191 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.438169e-01 0.191 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.438169e-01 0.191 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.438169e-01 0.191 0 0
cGMP effects R-HSA-418457 6.438169e-01 0.191 0 0
Physiological factors R-HSA-5578768 6.438169e-01 0.191 0 0
Glycerophospholipid catabolism R-HSA-6814848 6.438169e-01 0.191 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.438169e-01 0.191 0 0
Zinc transporters R-HSA-435354 6.438169e-01 0.191 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.438169e-01 0.191 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.459401e-01 0.190 0 0
Azathioprine ADME R-HSA-9748787 6.459401e-01 0.190 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.543394e-01 0.184 0 0
Cardiogenesis R-HSA-9733709 6.543394e-01 0.184 0 0
Meiotic recombination R-HSA-912446 6.572276e-01 0.182 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.630613e-01 0.178 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.630613e-01 0.178 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.636809e-01 0.178 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.636809e-01 0.178 0 0
Signaling by Activin R-HSA-1502540 6.636809e-01 0.178 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.636809e-01 0.178 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.636809e-01 0.178 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.636809e-01 0.178 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.636809e-01 0.178 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.636809e-01 0.178 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.636809e-01 0.178 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.640098e-01 0.178 0 0
SARS-CoV Infections R-HSA-9679506 6.640483e-01 0.178 0 0
Disease R-HSA-1643685 6.667408e-01 0.176 1 0
Effects of PIP2 hydrolysis R-HSA-114508 6.678406e-01 0.175 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.725673e-01 0.172 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.725673e-01 0.172 0 0
Synthesis of DNA R-HSA-69239 6.767424e-01 0.170 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.790179e-01 0.168 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.790179e-01 0.168 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.790179e-01 0.168 0 0
Nucleotide biosynthesis R-HSA-8956320 6.790179e-01 0.168 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.809122e-01 0.167 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.809122e-01 0.167 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 6.809122e-01 0.167 0 0
Signal amplification R-HSA-392518 6.809122e-01 0.167 0 0
Hyaluronan metabolism R-HSA-2142845 6.809122e-01 0.167 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.809122e-01 0.167 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.824382e-01 0.166 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.824382e-01 0.166 0 0
Activation of SMO R-HSA-5635838 6.824382e-01 0.166 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.824382e-01 0.166 0 0
Atorvastatin ADME R-HSA-9754706 6.824382e-01 0.166 0 0
Negative regulation of FLT3 R-HSA-9706369 6.824382e-01 0.166 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.824382e-01 0.166 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.824382e-01 0.166 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.843973e-01 0.165 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.895211e-01 0.161 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.895211e-01 0.161 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.919330e-01 0.160 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.935601e-01 0.159 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.935601e-01 0.159 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.999619e-01 0.155 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.999619e-01 0.155 0 0
Protein ubiquitination R-HSA-8852135 6.999619e-01 0.155 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.999619e-01 0.155 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.001504e-01 0.155 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.001504e-01 0.155 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.001504e-01 0.155 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.001504e-01 0.155 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.001504e-01 0.155 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.001504e-01 0.155 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.001504e-01 0.155 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.001504e-01 0.155 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.057910e-01 0.151 0 0
Deubiquitination R-HSA-5688426 7.077635e-01 0.150 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.097480e-01 0.149 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.097480e-01 0.149 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.168758e-01 0.145 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.168758e-01 0.145 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.168758e-01 0.145 1 1
Sulfide oxidation to sulfate R-HSA-1614517 7.168758e-01 0.145 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.168758e-01 0.145 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.168758e-01 0.145 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.168758e-01 0.145 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.172865e-01 0.144 0 0
Degradation of DVL R-HSA-4641258 7.176120e-01 0.144 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.176120e-01 0.144 0 0
Dual incision in TC-NER R-HSA-6782135 7.289460e-01 0.137 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.289460e-01 0.137 0 0
Elastic fibre formation R-HSA-1566948 7.290307e-01 0.137 0 0
Depurination R-HSA-73927 7.290307e-01 0.137 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.326691e-01 0.135 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.326691e-01 0.135 0 0
Mismatch Repair R-HSA-5358508 7.326691e-01 0.135 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.326691e-01 0.135 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.326691e-01 0.135 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.332713e-01 0.135 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.332713e-01 0.135 0 0
Stabilization of p53 R-HSA-69541 7.400553e-01 0.131 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.400553e-01 0.131 0 0
Pentose phosphate pathway R-HSA-71336 7.400553e-01 0.131 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.432485e-01 0.129 0 0
tRNA Aminoacylation R-HSA-379724 7.471329e-01 0.127 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.475824e-01 0.126 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.475824e-01 0.126 0 0
Pyrimidine biosynthesis R-HSA-500753 7.475824e-01 0.126 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.475824e-01 0.126 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.475824e-01 0.126 0 0
The NLRP3 inflammasome R-HSA-844456 7.475824e-01 0.126 0 0
Diseases of hemostasis R-HSA-9671793 7.475824e-01 0.126 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.475824e-01 0.126 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.475824e-01 0.126 0 0
Maturation of nucleoprotein R-HSA-9694631 7.475824e-01 0.126 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.475824e-01 0.126 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.503050e-01 0.125 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.506942e-01 0.125 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.506942e-01 0.125 0 0
Diseases of Immune System R-HSA-5260271 7.506942e-01 0.125 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.506942e-01 0.125 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.558540e-01 0.122 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.572566e-01 0.121 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.572566e-01 0.121 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.609560e-01 0.119 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.609560e-01 0.119 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.609560e-01 0.119 0 0
Signaling by NODAL R-HSA-1181150 7.616646e-01 0.118 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.616646e-01 0.118 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.616646e-01 0.118 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.616646e-01 0.118 0 0
Toll-like Receptor Cascades R-HSA-168898 7.625409e-01 0.118 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.648000e-01 0.116 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.708497e-01 0.113 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.720803e-01 0.112 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.749619e-01 0.111 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.749619e-01 0.111 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.749619e-01 0.111 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.749619e-01 0.111 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.749619e-01 0.111 0 0
Basigin interactions R-HSA-210991 7.749619e-01 0.111 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.749619e-01 0.111 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.803844e-01 0.108 0 0
Depyrimidination R-HSA-73928 7.803844e-01 0.108 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.861082e-01 0.105 0 0
Eicosanoids R-HSA-211979 7.875182e-01 0.104 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.875182e-01 0.104 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.875182e-01 0.104 0 0
Miscellaneous substrates R-HSA-211958 7.875182e-01 0.104 0 0
Ribavirin ADME R-HSA-9755088 7.875182e-01 0.104 0 0
Assembly Of The HIV Virion R-HSA-175474 7.875182e-01 0.104 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.895694e-01 0.103 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.960669e-01 0.099 0 0
Amine ligand-binding receptors R-HSA-375280 7.984140e-01 0.098 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.993745e-01 0.097 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.993745e-01 0.097 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.993745e-01 0.097 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.993745e-01 0.097 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.993745e-01 0.097 0 0
Ethanol oxidation R-HSA-71384 7.993745e-01 0.097 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.993745e-01 0.097 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.993745e-01 0.097 0 0
Nucleotide Excision Repair R-HSA-5696398 7.995043e-01 0.097 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.069276e-01 0.093 0 0
Nucleosome assembly R-HSA-774815 8.069276e-01 0.093 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.097110e-01 0.092 0 0
Regulated Necrosis R-HSA-5218859 8.102685e-01 0.091 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.105699e-01 0.091 0 0
Fatty acids R-HSA-211935 8.105699e-01 0.091 0 0
Formation of the ureteric bud R-HSA-9830674 8.105699e-01 0.091 0 0
Biosynthesis of maresins R-HSA-9018682 8.105699e-01 0.091 0 0
Growth hormone receptor signaling R-HSA-982772 8.105699e-01 0.091 0 0
ER-Phagosome pathway R-HSA-1236974 8.120904e-01 0.090 0 0
Neddylation R-HSA-8951664 8.136502e-01 0.090 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.151195e-01 0.089 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.151195e-01 0.089 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.151195e-01 0.089 0 0
Downstream TCR signaling R-HSA-202424 8.181672e-01 0.087 0 0
Immune System R-HSA-168256 8.210306e-01 0.086 1 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.211413e-01 0.086 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.211413e-01 0.086 0 0
Complex III assembly R-HSA-9865881 8.211413e-01 0.086 0 0
Interleukin-6 family signaling R-HSA-6783589 8.211413e-01 0.086 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.238010e-01 0.084 0 0
TCR signaling R-HSA-202403 8.273962e-01 0.082 0 0
Hedgehog 'on' state R-HSA-5632684 8.302527e-01 0.081 0 0
ECM proteoglycans R-HSA-3000178 8.302527e-01 0.081 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.305758e-01 0.081 0 0
G protein gated Potassium channels R-HSA-1296059 8.311233e-01 0.080 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.311233e-01 0.080 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.311233e-01 0.080 0 0
Tight junction interactions R-HSA-420029 8.311233e-01 0.080 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.311233e-01 0.080 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.311233e-01 0.080 0 0
Long-term potentiation R-HSA-9620244 8.311233e-01 0.080 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.311233e-01 0.080 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.311233e-01 0.080 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.378588e-01 0.077 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.378588e-01 0.077 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.405488e-01 0.075 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.405488e-01 0.075 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.405488e-01 0.075 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.405488e-01 0.075 0 0
TRP channels R-HSA-3295583 8.405488e-01 0.075 0 0
Urea cycle R-HSA-70635 8.405488e-01 0.075 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.405488e-01 0.075 0 0
Ion channel transport R-HSA-983712 8.415228e-01 0.075 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.448573e-01 0.073 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.494487e-01 0.071 0 0
Triglyceride biosynthesis R-HSA-75109 8.494487e-01 0.071 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.494487e-01 0.071 0 0
Insulin processing R-HSA-264876 8.494487e-01 0.071 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.566200e-01 0.067 0 0
Telomere Extension By Telomerase R-HSA-171319 8.578525e-01 0.067 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.578525e-01 0.067 0 0
Insulin receptor recycling R-HSA-77387 8.578525e-01 0.067 0 0
Inflammasomes R-HSA-622312 8.578525e-01 0.067 0 0
Prednisone ADME R-HSA-9757110 8.578525e-01 0.067 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.580367e-01 0.066 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.620785e-01 0.064 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.642353e-01 0.063 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.657875e-01 0.063 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.657875e-01 0.063 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.657875e-01 0.063 0 0
PPARA activates gene expression R-HSA-1989781 8.658549e-01 0.063 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.701849e-01 0.060 0 0
Regulation of insulin secretion R-HSA-422356 8.704362e-01 0.060 0 0
Infectious disease R-HSA-5663205 8.727792e-01 0.059 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.731534e-01 0.059 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.732801e-01 0.059 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.732801e-01 0.059 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.732801e-01 0.059 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.758939e-01 0.058 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.803549e-01 0.055 0 0
Budding and maturation of HIV virion R-HSA-162588 8.803549e-01 0.055 0 0
TNF signaling R-HSA-75893 8.813705e-01 0.055 0 0
Interleukin-1 signaling R-HSA-9020702 8.833577e-01 0.054 0 0
Chromosome Maintenance R-HSA-73886 8.853750e-01 0.053 0 0
Developmental Cell Lineages R-HSA-9734767 8.857329e-01 0.053 0 0
Dectin-2 family R-HSA-5621480 8.866230e-01 0.052 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.916592e-01 0.050 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.916592e-01 0.050 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.933426e-01 0.049 0 0
Formation of the cornified envelope R-HSA-6809371 8.960998e-01 0.048 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.964869e-01 0.047 0 0
Peroxisomal protein import R-HSA-9033241 8.964869e-01 0.047 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.974261e-01 0.047 0 0
RSV-host interactions R-HSA-9833110 8.988324e-01 0.046 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.992983e-01 0.046 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.992983e-01 0.046 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.992983e-01 0.046 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.992983e-01 0.046 0 0
Translation R-HSA-72766 8.995912e-01 0.046 0 0
RAB geranylgeranylation R-HSA-8873719 9.011138e-01 0.045 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.027578e-01 0.044 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.027578e-01 0.044 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.027578e-01 0.044 0 0
Dual Incision in GG-NER R-HSA-5696400 9.049218e-01 0.043 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.049218e-01 0.043 0 0
eNOS activation R-HSA-203615 9.049218e-01 0.043 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.049218e-01 0.043 0 0
Aquaporin-mediated transport R-HSA-445717 9.055470e-01 0.043 0 0
Gene Silencing by RNA R-HSA-211000 9.092226e-01 0.041 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.097940e-01 0.041 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.097940e-01 0.041 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.102316e-01 0.041 0 0
Regulation of Apoptosis R-HSA-169911 9.102316e-01 0.041 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.102316e-01 0.041 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.124693e-01 0.040 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.152452e-01 0.038 0 0
Calmodulin induced events R-HSA-111933 9.152452e-01 0.038 0 0
CaM pathway R-HSA-111997 9.152452e-01 0.038 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.152452e-01 0.038 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.152452e-01 0.038 0 0
G1/S-Specific Transcription R-HSA-69205 9.152452e-01 0.038 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.199790e-01 0.036 0 0
Degradation of AXIN R-HSA-4641257 9.199790e-01 0.036 0 0
Cleavage of the damaged purine R-HSA-110331 9.199790e-01 0.036 0 0
NCAM1 interactions R-HSA-419037 9.199790e-01 0.036 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.199790e-01 0.036 0 0
Collagen chain trimerization R-HSA-8948216 9.199790e-01 0.036 0 0
Cellular response to hypoxia R-HSA-1234174 9.214854e-01 0.036 0 0
Base Excision Repair R-HSA-73884 9.224556e-01 0.035 0 0
Ub-specific processing proteases R-HSA-5689880 9.228223e-01 0.035 0 0
Interleukin-1 family signaling R-HSA-446652 9.236700e-01 0.034 0 0
Inositol phosphate metabolism R-HSA-1483249 9.244445e-01 0.034 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.244487e-01 0.034 0 0
Purine salvage R-HSA-74217 9.244487e-01 0.034 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.244487e-01 0.034 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.244487e-01 0.034 0 0
Circadian clock R-HSA-9909396 9.258072e-01 0.033 0 0
DNA Replication R-HSA-69306 9.260853e-01 0.033 0 0
Kidney development R-HSA-9830369 9.284704e-01 0.032 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.286690e-01 0.032 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.314227e-01 0.031 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.326538e-01 0.030 0 0
Generation of second messenger molecules R-HSA-202433 9.326538e-01 0.030 0 0
G alpha (q) signalling events R-HSA-416476 9.333163e-01 0.030 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.341930e-01 0.030 0 0
FCGR activation R-HSA-2029481 9.341930e-01 0.030 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.364162e-01 0.029 0 0
Maturation of spike protein R-HSA-9694548 9.364162e-01 0.029 0 0
COPII-mediated vesicle transport R-HSA-204005 9.378562e-01 0.028 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.378562e-01 0.028 0 0
Extracellular matrix organization R-HSA-1474244 9.390482e-01 0.027 0 0
Interferon gamma signaling R-HSA-877300 9.392128e-01 0.027 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.397704e-01 0.027 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.399687e-01 0.027 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.399687e-01 0.027 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.399687e-01 0.027 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.399687e-01 0.027 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.407163e-01 0.027 0 0
Metabolism of cofactors R-HSA-8978934 9.407163e-01 0.027 0 0
Activation of GABAB receptors R-HSA-991365 9.433229e-01 0.025 0 0
GABA B receptor activation R-HSA-977444 9.433229e-01 0.025 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.433229e-01 0.025 0 0
Ca-dependent events R-HSA-111996 9.433229e-01 0.025 0 0
Purine catabolism R-HSA-74259 9.434510e-01 0.025 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.434510e-01 0.025 0 0
Telomere Maintenance R-HSA-157579 9.465583e-01 0.024 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.485645e-01 0.023 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.494800e-01 0.023 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.494800e-01 0.023 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.509529e-01 0.022 0 0
Somitogenesis R-HSA-9824272 9.523032e-01 0.021 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.523032e-01 0.021 0 0
DAG and IP3 signaling R-HSA-1489509 9.523032e-01 0.021 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.523032e-01 0.021 0 0
ABC-family proteins mediated transport R-HSA-382556 9.529028e-01 0.021 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.532178e-01 0.021 0 0
UCH proteinases R-HSA-5689603 9.532352e-01 0.021 0 0
Innate Immune System R-HSA-168249 9.535159e-01 0.021 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.549689e-01 0.020 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.549689e-01 0.020 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.549689e-01 0.020 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.549689e-01 0.020 0 0
Translation of Structural Proteins R-HSA-9694635 9.554158e-01 0.020 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.574857e-01 0.019 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.574857e-01 0.019 0 0
Cholesterol biosynthesis R-HSA-191273 9.574990e-01 0.019 0 0
tRNA processing R-HSA-72306 9.594057e-01 0.018 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.594887e-01 0.018 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.598620e-01 0.018 0 0
Gluconeogenesis R-HSA-70263 9.598620e-01 0.018 0 0
Metal ion SLC transporters R-HSA-425410 9.598620e-01 0.018 0 0
Opioid Signalling R-HSA-111885 9.602718e-01 0.018 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.607772e-01 0.017 0 0
Amyloid fiber formation R-HSA-977225 9.632035e-01 0.016 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.662239e-01 0.015 0 0
Complex IV assembly R-HSA-9864848 9.662239e-01 0.015 0 0
The phototransduction cascade R-HSA-2514856 9.662239e-01 0.015 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.681123e-01 0.014 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.681686e-01 0.014 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.681686e-01 0.014 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.696227e-01 0.013 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.729651e-01 0.012 0 0
G alpha (z) signalling events R-HSA-418597 9.731677e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.760848e-01 0.011 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.764002e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.783925e-01 0.009 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.786827e-01 0.009 0 0
Extension of Telomeres R-HSA-180786 9.786852e-01 0.009 0 0
Triglyceride metabolism R-HSA-8979227 9.786852e-01 0.009 0 0
GABA receptor activation R-HSA-977443 9.798774e-01 0.009 0 0
Glutathione conjugation R-HSA-156590 9.798774e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.804722e-01 0.009 0 0
SLC transporter disorders R-HSA-5619102 9.808041e-01 0.008 0 0
Collagen degradation R-HSA-1442490 9.810030e-01 0.008 0 0
Nucleotide salvage R-HSA-8956321 9.810030e-01 0.008 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.810030e-01 0.008 0 0
PLC beta mediated events R-HSA-112043 9.810030e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.820657e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.823066e-01 0.008 0 0
Xenobiotics R-HSA-211981 9.840163e-01 0.007 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.847484e-01 0.007 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.847868e-01 0.007 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.853698e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.853698e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.857549e-01 0.006 0 0
Phospholipid metabolism R-HSA-1483257 9.857842e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.861907e-01 0.006 0 0
G-protein mediated events R-HSA-112040 9.865521e-01 0.006 0 0
Nicotinate metabolism R-HSA-196807 9.865521e-01 0.006 0 0
O-linked glycosylation of mucins R-HSA-913709 9.873046e-01 0.006 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.873046e-01 0.006 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.873046e-01 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.873665e-01 0.006 0 0
Protein localization R-HSA-9609507 9.883648e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.886859e-01 0.005 0 0
Retinoid metabolism and transport R-HSA-975634 9.893192e-01 0.005 0 0
HCMV Late Events R-HSA-9610379 9.901753e-01 0.004 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.902662e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.904815e-01 0.004 0 0
Ca2+ pathway R-HSA-4086398 9.904815e-01 0.004 0 0
Metabolism of nucleotides R-HSA-15869 9.910252e-01 0.004 0 0
GPCR downstream signalling R-HSA-388396 9.919156e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.928640e-01 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.929528e-01 0.003 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.939970e-01 0.003 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.939970e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.948470e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.949544e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.949544e-01 0.002 0 0
Co-inhibition by PD-1 R-HSA-389948 9.950614e-01 0.002 0 0
Sphingolipid metabolism R-HSA-428157 9.952612e-01 0.002 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.955002e-01 0.002 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.957523e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.959903e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.962854e-01 0.002 0 0
Keratinization R-HSA-6805567 9.963064e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.966273e-01 0.001 0 0
Bacterial Infection Pathways R-HSA-9824439 9.970427e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.974723e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.976608e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.977722e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.978727e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.978741e-01 0.001 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.979661e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.980552e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.981058e-01 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.985806e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.986094e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.989181e-01 0.000 0 0
Stimuli-sensing channels R-HSA-2672351 9.989962e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.990525e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.990815e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.991559e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.992149e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.993252e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.993291e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.993882e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.994683e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.996241e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.996652e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.997192e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.997263e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997356e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997377e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.997892e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.997892e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.998425e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.998488e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998553e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.998594e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998673e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999062e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999165e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999352e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999443e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999544e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999583e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999917e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999917e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999973e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999984e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999993e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999995e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999997e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999999e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle Checkpoints R-HSA-69620 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 1 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 1 0
Metabolism of RNA R-HSA-8953854 1.110223e-16 15.955 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.992007e-16 15.000 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.992007e-16 15.000 0 0
Nervous system development R-HSA-9675108 9.992007e-16 15.000 0 0
Axon guidance R-HSA-422475 1.110223e-15 14.955 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.995204e-15 14.222 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.164935e-14 13.665 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.898481e-13 12.722 0 0
Signaling by ROBO receptors R-HSA-376176 4.377609e-13 12.359 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.682765e-12 11.774 0 0
Mitotic Prometaphase R-HSA-68877 7.153056e-12 11.146 0 0
Cell-Cell communication R-HSA-1500931 7.886913e-12 11.103 0 0
Translation initiation complex formation R-HSA-72649 8.419598e-12 11.075 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.034173e-11 10.985 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.933320e-11 10.714 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.016609e-11 10.695 0 0
Apoptotic execution phase R-HSA-75153 2.262013e-11 10.646 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.442224e-11 10.264 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.821010e-11 10.235 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.167851e-10 9.933 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.692594e-10 9.771 0 0
mRNA Splicing R-HSA-72172 1.860817e-10 9.730 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.514127e-10 9.600 0 0
Mitotic Anaphase R-HSA-68882 2.738532e-10 9.562 0 0
G2/M Checkpoints R-HSA-69481 3.122038e-10 9.506 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.263374e-10 9.486 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.415074e-10 9.355 0 0
Peptide chain elongation R-HSA-156902 5.751313e-10 9.240 0 0
Ribosome-associated quality control R-HSA-9948299 7.572473e-10 9.121 0 0
Cell junction organization R-HSA-446728 7.253678e-10 9.139 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.275950e-10 9.138 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.462332e-10 9.073 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.462332e-10 9.073 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.436470e-10 9.025 0 0
DNA Double Strand Break Response R-HSA-5693606 1.086075e-09 8.964 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.339625e-09 8.873 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.652164e-09 8.782 0 0
Separation of Sister Chromatids R-HSA-2467813 1.554320e-09 8.808 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.664949e-09 8.779 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.664949e-09 8.779 0 0
Chromatin organization R-HSA-4839726 2.224428e-09 8.653 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.355934e-09 8.628 0 0
Chromatin modifying enzymes R-HSA-3247509 2.386899e-09 8.622 0 0
G2/M Transition R-HSA-69275 2.994234e-09 8.524 0 0
Cellular response to heat stress R-HSA-3371556 3.920330e-09 8.407 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.744329e-09 8.324 0 0
Adherens junctions interactions R-HSA-418990 1.096694e-08 7.960 0 0
Influenza Infection R-HSA-168255 1.192390e-08 7.924 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.307043e-08 7.884 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.460094e-08 7.836 0 0
Cellular Senescence R-HSA-2559583 1.416909e-08 7.849 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.781728e-08 7.749 1 0
Eukaryotic Translation Termination R-HSA-72764 1.938846e-08 7.712 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.404616e-08 7.619 0 0
Cell-cell junction organization R-HSA-421270 3.032524e-08 7.518 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.685050e-08 7.434 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.748425e-08 7.426 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.593572e-08 7.338 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.279573e-08 7.202 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.555277e-08 7.183 0 0
Selenocysteine synthesis R-HSA-2408557 7.886333e-08 7.103 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.920612e-08 7.101 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.550110e-08 7.068 0 0
rRNA processing R-HSA-72312 8.800474e-08 7.055 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.038565e-07 6.984 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.137569e-07 6.944 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.331806e-07 6.876 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.331806e-07 6.876 1 1
Signaling by ALK in cancer R-HSA-9700206 1.331806e-07 6.876 1 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.517483e-07 6.819 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.517483e-07 6.819 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.580534e-07 6.801 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.938765e-07 6.712 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.937263e-07 6.713 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.024226e-07 6.694 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.101495e-07 6.677 0 0
Apoptosis R-HSA-109581 2.157290e-07 6.666 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.161345e-07 6.665 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.261346e-07 6.646 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.988221e-07 6.525 0 0
Viral mRNA Translation R-HSA-192823 3.303196e-07 6.481 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.482627e-07 6.458 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.482627e-07 6.458 0 0
ESR-mediated signaling R-HSA-8939211 3.621983e-07 6.441 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.879833e-07 6.411 0 0
Mitotic Prophase R-HSA-68875 4.025226e-07 6.395 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.219484e-07 6.282 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.950132e-07 6.158 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.079088e-07 6.150 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.284833e-07 6.082 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.076421e-07 6.042 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.035897e-06 5.985 0 0
Nucleosome assembly R-HSA-774815 1.035897e-06 5.985 0 0
Centrosome maturation R-HSA-380287 1.129385e-06 5.947 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.228668e-06 5.911 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.336740e-06 5.874 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.596647e-06 5.797 0 0
Homology Directed Repair R-HSA-5693538 1.681898e-06 5.774 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.825077e-06 5.739 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.825077e-06 5.739 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.894678e-06 5.722 0 0
Meiotic synapsis R-HSA-1221632 3.199321e-06 5.495 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.086837e-06 5.510 0 0
Programmed Cell Death R-HSA-5357801 3.274264e-06 5.485 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.304862e-06 5.481 0 0
Diseases of programmed cell death R-HSA-9645723 3.311571e-06 5.480 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.620453e-06 5.441 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.700723e-06 5.328 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.700723e-06 5.328 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.417869e-06 5.266 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.417869e-06 5.266 0 0
HATs acetylate histones R-HSA-3214847 6.486184e-06 5.188 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.543791e-06 5.184 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.476724e-06 5.126 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.620488e-06 5.118 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.978277e-06 5.098 0 0
Regulation of CDH1 Function R-HSA-9764561 9.015086e-06 5.045 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.480194e-06 5.023 0 0
Interleukin-12 signaling R-HSA-9020591 1.093161e-05 4.961 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.099908e-05 4.959 0 0
DNA Repair R-HSA-73894 1.176203e-05 4.930 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.255588e-05 4.901 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.511623e-05 4.821 0 0
HDACs deacetylate histones R-HSA-3214815 1.630147e-05 4.788 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.653413e-05 4.782 0 0
L1CAM interactions R-HSA-373760 1.547612e-05 4.810 0 0
RNA Polymerase I Transcription R-HSA-73864 1.653413e-05 4.782 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.714593e-05 4.766 0 0
Interleukin-12 family signaling R-HSA-447115 1.797354e-05 4.745 0 0
HSF1-dependent transactivation R-HSA-3371571 1.801168e-05 4.744 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.901924e-05 4.721 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.943252e-05 4.711 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.085662e-05 4.681 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.277109e-05 4.643 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.342234e-05 4.630 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.374427e-05 4.624 0 0
Meiosis R-HSA-1500620 2.549823e-05 4.593 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.634256e-05 4.579 0 0
Cellular response to starvation R-HSA-9711097 2.707392e-05 4.567 0 0
DNA Replication R-HSA-69306 2.858520e-05 4.544 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.873507e-05 4.542 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.979665e-05 4.526 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.873596e-05 4.412 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.085482e-05 4.389 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.085482e-05 4.389 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.402338e-05 4.356 0 0
Selective autophagy R-HSA-9663891 5.297655e-05 4.276 0 0
EPH-Ephrin signaling R-HSA-2682334 5.307788e-05 4.275 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.034916e-05 4.219 0 0
Defective pyroptosis R-HSA-9710421 6.562271e-05 4.183 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.677208e-05 4.175 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.942421e-05 4.158 0 0
Aggrephagy R-HSA-9646399 7.176805e-05 4.144 0 0
Smooth Muscle Contraction R-HSA-445355 8.371432e-05 4.077 0 0
DNA methylation R-HSA-5334118 8.385226e-05 4.076 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.566184e-05 4.067 0 0
Translation R-HSA-72766 1.092358e-04 3.962 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.245035e-04 3.905 0 0
Disorders of Developmental Biology R-HSA-9675151 1.335777e-04 3.874 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.363565e-04 3.865 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.432699e-04 3.844 0 0
Signaling by VEGF R-HSA-194138 1.463828e-04 3.835 0 0
Signal Transduction R-HSA-162582 1.574091e-04 3.803 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.577470e-04 3.802 0 0
Packaging Of Telomere Ends R-HSA-171306 1.577470e-04 3.802 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.847007e-04 3.734 0 0
mRNA 3'-end processing R-HSA-72187 1.847007e-04 3.734 0 0
Membrane Trafficking R-HSA-199991 1.859558e-04 3.731 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.903866e-04 3.720 0 0
Signaling by Hippo R-HSA-2028269 1.983200e-04 3.703 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.000594e-04 3.699 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.015164e-04 3.696 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.040671e-04 3.690 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.144132e-04 3.669 0 0
Attenuation phase R-HSA-3371568 2.171391e-04 3.663 0 0
Host Interactions of HIV factors R-HSA-162909 2.303803e-04 3.638 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.181500e-04 3.661 0 0
Signaling by WNT R-HSA-195721 2.314227e-04 3.636 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.413037e-04 3.617 0 0
S Phase R-HSA-69242 2.416604e-04 3.617 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.429985e-04 3.614 0 0
Semaphorin interactions R-HSA-373755 2.470485e-04 3.607 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.527553e-04 3.597 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.755962e-04 3.560 0 0
Protein folding R-HSA-391251 2.779132e-04 3.556 0 0
Co-inhibition by PD-1 R-HSA-389948 2.851933e-04 3.545 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.999770e-04 3.523 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.094476e-04 3.509 0 0
Pervasive developmental disorders R-HSA-9005895 3.189250e-04 3.496 0 0
Disorders of Nervous System Development R-HSA-9697154 3.189250e-04 3.496 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.189250e-04 3.496 0 0
Striated Muscle Contraction R-HSA-390522 3.430522e-04 3.465 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.472459e-04 3.459 0 0
Protein ubiquitination R-HSA-8852135 3.565966e-04 3.448 0 0
Signaling by ERBB2 R-HSA-1227986 3.519086e-04 3.454 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.438097e-04 3.464 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.531654e-04 3.452 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.588186e-04 3.445 0 0
Developmental Biology R-HSA-1266738 3.750661e-04 3.426 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.772220e-04 3.423 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.772220e-04 3.423 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.772220e-04 3.423 0 0
Signaling by RAS mutants R-HSA-6802949 3.772220e-04 3.423 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.777162e-04 3.423 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.777162e-04 3.423 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.803834e-04 3.420 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.084354e-04 3.389 0 0
Selenoamino acid metabolism R-HSA-2408522 4.087336e-04 3.389 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.300811e-04 3.366 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.412966e-04 3.355 0 0
Recycling pathway of L1 R-HSA-437239 4.656600e-04 3.332 0 0
Signaling by NOTCH R-HSA-157118 4.761305e-04 3.322 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.878230e-04 3.312 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.292466e-04 3.276 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.451609e-04 3.263 0 0
Post NMDA receptor activation events R-HSA-438064 5.451609e-04 3.263 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.597099e-04 3.252 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.222452e-04 3.206 0 0
Chromosome Maintenance R-HSA-73886 6.334732e-04 3.198 0 0
Autophagy R-HSA-9612973 5.933057e-04 3.227 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.631165e-04 3.178 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.631165e-04 3.178 0 0
Cilium Assembly R-HSA-5617833 6.003192e-04 3.222 0 0
Macroautophagy R-HSA-1632852 6.723347e-04 3.172 0 0
Gene Silencing by RNA R-HSA-211000 6.771651e-04 3.169 0 0
HSF1 activation R-HSA-3371511 7.114570e-04 3.148 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.120209e-04 3.148 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.155986e-04 3.145 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 7.325475e-04 3.135 0 0
HIV Infection R-HSA-162906 7.396733e-04 3.131 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.480950e-04 3.126 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.738969e-04 3.111 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.052807e-04 3.094 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.399471e-04 3.076 0 0
Cleavage of the damaged purine R-HSA-110331 8.923804e-04 3.049 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.994456e-04 3.046 0 0
Muscle contraction R-HSA-397014 9.656359e-04 3.015 0 0
Meiotic recombination R-HSA-912446 1.021726e-03 2.991 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.024585e-03 2.989 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.063340e-03 2.973 0 0
Depurination R-HSA-73927 1.110782e-03 2.954 0 0
G1/S Transition R-HSA-69206 1.141645e-03 2.942 0 0
Gene expression (Transcription) R-HSA-74160 1.150171e-03 2.939 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.152253e-03 2.938 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.211896e-03 2.917 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.246014e-03 2.904 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.364191e-03 2.865 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.372567e-03 2.862 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.372567e-03 2.862 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.466800e-03 2.834 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.596953e-03 2.797 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.427713e-03 2.845 0 0
MAPK family signaling cascades R-HSA-5683057 1.401548e-03 2.853 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.631915e-03 2.787 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.684239e-03 2.774 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.684239e-03 2.774 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.751944e-03 2.756 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.751944e-03 2.756 0 0
Degradation of CDH1 R-HSA-9766229 1.751944e-03 2.756 0 0
Josephin domain DUBs R-HSA-5689877 1.836180e-03 2.736 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.836180e-03 2.736 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.844320e-03 2.734 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.885950e-03 2.724 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.993853e-03 2.700 0 0
Nephrin family interactions R-HSA-373753 1.993853e-03 2.700 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.052908e-03 2.688 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.066060e-03 2.685 0 0
HIV Life Cycle R-HSA-162587 2.125822e-03 2.672 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.255640e-03 2.647 0 0
Regulation of PTEN localization R-HSA-8948747 2.255640e-03 2.647 0 0
Neurodegenerative Diseases R-HSA-8863678 2.379077e-03 2.624 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.379077e-03 2.624 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.413817e-03 2.617 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.435552e-03 2.613 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.482616e-03 2.605 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.531778e-03 2.597 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.590330e-03 2.587 0 0
Deubiquitination R-HSA-5688426 2.590460e-03 2.587 0 0
Late endosomal microautophagy R-HSA-9615710 2.659225e-03 2.575 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.761594e-03 2.559 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.040985e-03 2.517 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.040985e-03 2.517 0 0
Long-term potentiation R-HSA-9620244 3.040985e-03 2.517 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.320747e-03 2.479 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.844932e-03 2.546 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.935800e-03 2.532 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.062474e-03 2.514 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.955174e-03 2.529 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.320747e-03 2.479 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.908317e-03 2.536 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.040985e-03 2.517 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.208695e-03 2.494 0 0
Signaling by PTK6 R-HSA-8848021 3.208695e-03 2.494 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.208695e-03 2.494 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.992748e-03 2.524 0 0
Depyrimidination R-HSA-73928 2.992748e-03 2.524 0 0
Ub-specific processing proteases R-HSA-5689880 3.342944e-03 2.476 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.473134e-03 2.459 0 0
Nuclear import of Rev protein R-HSA-180746 3.490495e-03 2.457 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.570934e-03 2.447 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.585179e-03 2.445 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.585179e-03 2.445 0 0
Ephrin signaling R-HSA-3928664 3.769607e-03 2.424 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.004934e-03 2.397 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.004934e-03 2.397 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.008276e-03 2.397 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.008383e-03 2.397 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.008383e-03 2.397 0 0
Amyloid fiber formation R-HSA-977225 4.081648e-03 2.389 0 0
Cyclin D associated events in G1 R-HSA-69231 4.261175e-03 2.370 0 0
G1 Phase R-HSA-69236 4.261175e-03 2.370 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.293026e-03 2.367 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.395213e-03 2.357 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.488278e-03 2.348 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.644510e-03 2.333 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.644510e-03 2.333 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.770480e-03 2.321 1 0
Regulation of TP53 Activity R-HSA-5633007 4.786315e-03 2.320 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.938286e-03 2.306 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.129151e-03 2.290 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.137698e-03 2.289 0 0
CaM pathway R-HSA-111997 5.137698e-03 2.289 0 0
Calmodulin induced events R-HSA-111933 5.137698e-03 2.289 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.196486e-03 2.284 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.423326e-03 2.266 0 0
Gap junction degradation R-HSA-190873 5.423326e-03 2.266 0 0
ALK mutants bind TKIs R-HSA-9700645 5.423326e-03 2.266 1 1
GP1b-IX-V activation signalling R-HSA-430116 5.423326e-03 2.266 0 0
Signaling by EGFR R-HSA-177929 5.480247e-03 2.261 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.480247e-03 2.261 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.370215e-03 2.196 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.370215e-03 2.196 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.951174e-03 2.225 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.134244e-03 2.212 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.936645e-03 2.226 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.953899e-03 2.158 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.921752e-03 2.160 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.921752e-03 2.160 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.921752e-03 2.160 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.167971e-03 2.210 0 0
Signal transduction by L1 R-HSA-445144 6.370215e-03 2.196 0 0
Orc1 removal from chromatin R-HSA-68949 6.662478e-03 2.176 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.263054e-03 2.203 1 1
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.134244e-03 2.212 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.167971e-03 2.210 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.994526e-03 2.222 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.601437e-03 2.252 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.167971e-03 2.210 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.997893e-03 2.222 0 0
Base Excision Repair R-HSA-73884 6.894103e-03 2.162 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.339003e-03 2.198 0 0
Reproduction R-HSA-1474165 6.932690e-03 2.159 0 0
Signaling by Interleukins R-HSA-449147 6.212485e-03 2.207 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.062724e-03 2.151 0 0
PKR-mediated signaling R-HSA-9833482 7.186523e-03 2.143 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.186523e-03 2.143 0 0
Ca-dependent events R-HSA-111996 7.193837e-03 2.143 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.356293e-03 2.133 0 0
Nucleotide Excision Repair R-HSA-5696398 7.377736e-03 2.132 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.406770e-03 2.130 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.406770e-03 2.130 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.567606e-03 2.121 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.717647e-03 2.113 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.726107e-03 2.112 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.726107e-03 2.112 0 0
HCMV Early Events R-HSA-9609690 7.793337e-03 2.108 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.870520e-03 2.104 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.202425e-03 2.086 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.408470e-03 2.075 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.408470e-03 2.075 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.448947e-03 2.073 0 0
Viral Infection Pathways R-HSA-9824446 8.508994e-03 2.070 0 0
HDMs demethylate histones R-HSA-3214842 8.646325e-03 2.063 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.718623e-03 2.060 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.877797e-03 2.052 0 0
Mitophagy R-HSA-5205647 8.877797e-03 2.052 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.902556e-03 2.050 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.902556e-03 2.050 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.077594e-03 2.042 0 0
MHC class II antigen presentation R-HSA-2132295 9.116438e-03 2.040 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.871050e-03 2.006 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.033122e-02 1.986 0 0
Regulation of KIT signaling R-HSA-1433559 1.033122e-02 1.986 0 0
Myogenesis R-HSA-525793 1.060434e-02 1.975 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.070295e-02 1.970 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.076936e-02 1.968 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.086376e-02 1.964 0 0
PECAM1 interactions R-HSA-210990 1.102608e-02 1.958 0 0
DAG and IP3 signaling R-HSA-1489509 1.147448e-02 1.940 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.147448e-02 1.940 0 0
Ion homeostasis R-HSA-5578775 1.170457e-02 1.932 0 0
mTORC1-mediated signalling R-HSA-166208 1.261036e-02 1.899 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.288182e-02 1.890 0 0
Signaling by TGFB family members R-HSA-9006936 1.290230e-02 1.889 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.606705e-02 1.794 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.606705e-02 1.794 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.606705e-02 1.794 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.606705e-02 1.794 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.606705e-02 1.794 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.606705e-02 1.794 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.408114e-02 1.851 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.562289e-02 1.806 0 0
Formation of annular gap junctions R-HSA-196025 1.562289e-02 1.806 0 0
NF-kB is activated and signals survival R-HSA-209560 1.498502e-02 1.824 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.352290e-02 1.869 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.546256e-02 1.811 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.467957e-02 1.833 0 0
MAP2K and MAPK activation R-HSA-5674135 1.401589e-02 1.853 0 0
Neutrophil degranulation R-HSA-6798695 1.626181e-02 1.789 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.425939e-02 1.846 0 0
Degradation of DVL R-HSA-4641258 1.467957e-02 1.833 0 0
DCC mediated attractive signaling R-HSA-418885 1.352290e-02 1.869 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.550839e-02 1.809 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.401589e-02 1.853 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.401589e-02 1.853 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.334380e-02 1.875 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.408114e-02 1.851 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.537092e-02 1.813 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.736529e-02 1.760 0 0
p75NTR signals via NF-kB R-HSA-193639 1.352290e-02 1.869 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.502599e-02 1.823 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.527494e-02 1.816 0 0
Regulation of signaling by CBL R-HSA-912631 1.488690e-02 1.827 0 0
Signaling by NOTCH4 R-HSA-9013694 1.343866e-02 1.872 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.562289e-02 1.806 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.488690e-02 1.827 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.401589e-02 1.853 0 0
Telomere Maintenance R-HSA-157579 1.742306e-02 1.759 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.847860e-02 1.733 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.876217e-02 1.727 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.940785e-02 1.712 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.983523e-02 1.703 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.983523e-02 1.703 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.983523e-02 1.703 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.987327e-02 1.702 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.990609e-02 1.701 0 0
Stabilization of p53 R-HSA-69541 1.990609e-02 1.701 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.999551e-02 1.699 0 0
Gap junction trafficking and regulation R-HSA-157858 1.999551e-02 1.699 0 0
PCP/CE pathway R-HSA-4086400 2.072932e-02 1.683 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.081564e-02 1.682 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.081564e-02 1.682 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.100135e-02 1.678 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.100135e-02 1.678 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.100135e-02 1.678 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.148707e-02 1.668 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.172528e-02 1.663 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.172528e-02 1.663 0 0
Maturation of protein E R-HSA-9683683 2.172528e-02 1.663 0 0
Maturation of protein E R-HSA-9694493 2.172528e-02 1.663 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.175177e-02 1.663 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.175177e-02 1.663 0 0
PLC beta mediated events R-HSA-112043 2.175369e-02 1.662 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.191867e-02 1.659 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.191867e-02 1.659 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.191867e-02 1.659 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.191867e-02 1.659 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.192540e-02 1.659 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.265080e-02 1.645 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.265080e-02 1.645 0 0
Basigin interactions R-HSA-210991 2.265080e-02 1.645 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.278564e-02 1.642 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.298699e-02 1.639 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.298699e-02 1.639 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.298699e-02 1.639 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.298699e-02 1.639 0 0
Regulation of Apoptosis R-HSA-169911 2.444291e-02 1.612 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.454011e-02 1.610 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.454011e-02 1.610 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.454011e-02 1.610 0 0
Signaling by ERBB4 R-HSA-1236394 2.518900e-02 1.599 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.565501e-02 1.591 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.577198e-02 1.589 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.577198e-02 1.589 0 0
Trafficking of AMPA receptors R-HSA-399719 2.577198e-02 1.589 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.640545e-02 1.578 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.640545e-02 1.578 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.640545e-02 1.578 0 0
FLT3 Signaling R-HSA-9607240 2.640545e-02 1.578 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.723812e-02 1.565 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.723812e-02 1.565 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.744542e-02 1.562 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.744542e-02 1.562 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.744542e-02 1.562 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.791094e-02 1.554 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.827698e-02 1.549 0 0
RNA Polymerase III Transcription R-HSA-74158 2.827698e-02 1.549 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.827698e-02 1.549 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.863055e-02 1.543 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.901128e-02 1.537 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.926047e-02 1.534 0 0
Pexophagy R-HSA-9664873 2.926047e-02 1.534 0 0
G0 and Early G1 R-HSA-1538133 3.007927e-02 1.522 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.018001e-02 1.520 0 0
Nef and signal transduction R-HSA-164944 3.148955e-02 1.502 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.168858e-02 1.499 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.168858e-02 1.499 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.251109e-02 1.488 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.251109e-02 1.488 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.259259e-02 1.487 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.337238e-02 1.477 0 0
Cellular response to hypoxia R-HSA-1234174 3.367222e-02 1.473 0 0
MTOR signalling R-HSA-165159 3.432828e-02 1.464 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.487164e-02 1.458 0 0
G-protein beta:gamma signalling R-HSA-397795 3.487164e-02 1.458 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.487164e-02 1.458 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.531864e-02 1.452 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.534801e-02 1.452 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.549846e-02 1.450 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.701825e-02 1.432 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.701825e-02 1.432 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.701825e-02 1.432 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.701825e-02 1.432 0 0
Kinesins R-HSA-983189 3.701825e-02 1.432 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.701825e-02 1.432 0 0
Vesicle-mediated transport R-HSA-5653656 3.714162e-02 1.430 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.732684e-02 1.428 0 0
Glycolysis R-HSA-70171 3.849843e-02 1.415 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.003164e-02 1.398 0 0
Cellular response to chemical stress R-HSA-9711123 4.005273e-02 1.397 1 0
Vpu mediated degradation of CD4 R-HSA-180534 4.017142e-02 1.396 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.017142e-02 1.396 0 0
PTEN Regulation R-HSA-6807070 4.024755e-02 1.395 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.045721e-02 1.393 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.045721e-02 1.393 0 0
Protein methylation R-HSA-8876725 4.045721e-02 1.393 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.045721e-02 1.393 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.069813e-02 1.390 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.104726e-02 1.387 0 0
G-protein mediated events R-HSA-112040 4.116345e-02 1.385 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.920142e-02 1.228 0 0
Regulation of gap junction activity R-HSA-191650 4.490253e-02 1.348 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.490253e-02 1.348 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.490253e-02 1.348 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.490253e-02 1.348 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.345333e-02 1.362 0 0
Recycling of eIF2:GDP R-HSA-72731 4.345333e-02 1.362 0 0
Activation of RAC1 R-HSA-428540 4.870191e-02 1.312 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.070809e-02 1.217 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.070809e-02 1.217 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.953306e-02 1.305 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.976380e-02 1.224 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.313263e-02 1.365 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.977805e-02 1.303 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.192774e-02 1.208 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.192774e-02 1.208 0 0
Dual Incision in GG-NER R-HSA-5696400 4.599859e-02 1.337 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.237053e-02 1.281 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.917452e-02 1.308 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.120803e-02 1.213 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.538196e-02 1.257 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.129675e-02 1.213 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.129675e-02 1.213 0 0
snRNP Assembly R-HSA-191859 6.099627e-02 1.215 0 0
Metabolism of non-coding RNA R-HSA-194441 6.099627e-02 1.215 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.927553e-02 1.307 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.502705e-02 1.347 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.977805e-02 1.303 0 0
UCH proteinases R-HSA-5689603 5.379857e-02 1.269 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.535050e-02 1.257 0 0
EGFR downregulation R-HSA-182971 5.706429e-02 1.244 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.917452e-02 1.308 0 0
Metalloprotease DUBs R-HSA-5689901 6.192774e-02 1.208 0 0
RET signaling R-HSA-8853659 5.930182e-02 1.227 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.453019e-02 1.263 0 0
RMTs methylate histone arginines R-HSA-3214858 4.381093e-02 1.358 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.402325e-02 1.267 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.986651e-02 1.302 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.603993e-02 1.337 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.237053e-02 1.281 0 0
HCMV Infection R-HSA-9609646 6.136485e-02 1.212 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.920142e-02 1.228 0 0
RAF activation R-HSA-5673000 4.599859e-02 1.337 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.237053e-02 1.281 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.237053e-02 1.281 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.402325e-02 1.267 0 0
Gap junction trafficking R-HSA-190828 4.381093e-02 1.358 0 0
Opioid Signalling R-HSA-111885 5.238257e-02 1.281 0 0
RNA Polymerase II Transcription R-HSA-73857 4.739045e-02 1.324 0 0
Synthesis of DNA R-HSA-69239 4.402953e-02 1.356 0 0
CHL1 interactions R-HSA-447041 4.345333e-02 1.362 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.870191e-02 1.312 0 0
tRNA processing in the nucleus R-HSA-6784531 4.541782e-02 1.343 0 0
Interferon Signaling R-HSA-913531 5.317917e-02 1.274 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.991662e-02 1.302 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.870191e-02 1.312 0 0
Ion transport by P-type ATPases R-HSA-936837 5.507801e-02 1.259 0 0
Oncogene Induced Senescence R-HSA-2559585 5.237053e-02 1.281 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.496999e-02 1.260 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.706429e-02 1.244 0 0
FLT3 signaling in disease R-HSA-9682385 5.930182e-02 1.227 0 0
Negative regulation of FLT3 R-HSA-9706369 4.953306e-02 1.305 0 0
Modulation by Mtb of host immune system R-HSA-9637628 5.763167e-02 1.239 0 0
Hedgehog 'off' state R-HSA-5610787 6.227171e-02 1.206 0 0
G alpha (12/13) signalling events R-HSA-416482 6.369611e-02 1.196 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.495376e-02 1.187 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.495376e-02 1.187 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.495376e-02 1.187 0 0
G2 Phase R-HSA-68911 6.495376e-02 1.187 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.495376e-02 1.187 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.495376e-02 1.187 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.500527e-02 1.187 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.676303e-02 1.175 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.676303e-02 1.175 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.676303e-02 1.175 0 0
Degradation of AXIN R-HSA-4641257 6.680403e-02 1.175 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.680403e-02 1.175 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.697681e-02 1.174 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.768488e-02 1.170 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.768488e-02 1.170 0 0
Co-stimulation by CD28 R-HSA-389356 6.789758e-02 1.168 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.108864e-02 1.148 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.108864e-02 1.148 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.108864e-02 1.148 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.115992e-02 1.148 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.282643e-02 1.138 0 0
MAP kinase activation R-HSA-450294 7.333402e-02 1.135 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.361069e-02 1.133 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.361069e-02 1.133 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.361069e-02 1.133 0 0
WNT mediated activation of DVL R-HSA-201688 7.398240e-02 1.131 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.398240e-02 1.131 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.398240e-02 1.131 0 0
Unwinding of DNA R-HSA-176974 7.398240e-02 1.131 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.424199e-02 1.129 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.424199e-02 1.129 0 0
Signaling by NOTCH3 R-HSA-9012852 7.435525e-02 1.129 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.476605e-02 1.126 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.528066e-02 1.123 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.742555e-02 1.111 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.742555e-02 1.111 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.843022e-02 1.106 0 0
HIV elongation arrest and recovery R-HSA-167287 8.103169e-02 1.091 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.103169e-02 1.091 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.151063e-02 1.089 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.210577e-02 1.086 0 0
Signaling by ALK R-HSA-201556 8.355176e-02 1.078 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.371749e-02 1.077 0 0
GAB1 signalosome R-HSA-180292 8.371749e-02 1.077 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.371749e-02 1.077 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.371749e-02 1.077 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.371749e-02 1.077 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.371749e-02 1.077 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.371749e-02 1.077 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.838723e-02 1.054 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 8.838723e-02 1.054 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.838723e-02 1.054 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.838723e-02 1.054 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.838723e-02 1.054 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.838723e-02 1.054 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.849968e-02 1.053 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.902328e-02 1.050 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.902328e-02 1.050 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.927531e-02 1.049 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.927531e-02 1.049 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.927531e-02 1.049 0 0
Signaling by NOTCH1 R-HSA-1980143 8.964047e-02 1.047 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.073602e-02 1.042 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.202783e-02 1.036 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.241450e-02 1.034 0 0
2-LTR circle formation R-HSA-164843 9.241450e-02 1.034 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.344011e-02 1.029 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.464657e-02 1.024 0 0
Regulation of TP53 Expression R-HSA-6804754 9.681835e-02 1.014 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 9.681835e-02 1.014 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 9.681835e-02 1.014 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.681835e-02 1.014 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 9.681835e-02 1.014 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 9.681835e-02 1.014 0 0
ER-Phagosome pathway R-HSA-1236974 9.720249e-02 1.012 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.741880e-02 1.011 0 0
Other interleukin signaling R-HSA-449836 9.741880e-02 1.011 0 0
Glucose metabolism R-HSA-70326 9.805110e-02 1.009 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.928236e-02 1.003 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.963302e-02 1.002 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.011818e-01 0.995 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.015453e-01 0.993 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.015453e-01 0.993 0 0
Deadenylation of mRNA R-HSA-429947 1.015453e-01 0.993 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.015453e-01 0.993 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.026421e-01 0.989 0 0
Activation of the pre-replicative complex R-HSA-68962 1.032566e-01 0.986 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.032566e-01 0.986 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.057573e-01 0.976 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.057573e-01 0.976 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.057573e-01 0.976 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.057573e-01 0.976 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.057573e-01 0.976 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.057573e-01 0.976 0 0
Hemostasis R-HSA-109582 1.064072e-01 0.973 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.074158e-01 0.969 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.122331e-01 0.950 0 0
Glycogen synthesis R-HSA-3322077 1.122331e-01 0.950 0 0
Negative regulation of MET activity R-HSA-6807004 1.122331e-01 0.950 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.122541e-01 0.950 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.127969e-01 0.948 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.130601e-01 0.947 0 0
Signaling by LTK in cancer R-HSA-9842640 1.148097e-01 0.940 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.148097e-01 0.940 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.148097e-01 0.940 0 0
Interleukin-7 signaling R-HSA-1266695 1.149724e-01 0.939 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.155197e-01 0.937 0 0
Circadian clock R-HSA-9909396 1.195407e-01 0.922 0 0
GPER1 signaling R-HSA-9634597 1.210379e-01 0.917 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.222685e-01 0.913 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.222685e-01 0.913 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.222685e-01 0.913 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.236172e-01 0.908 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.236172e-01 0.908 0 0
Phosphorylation of the APC/C R-HSA-176412 1.236172e-01 0.908 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.236172e-01 0.908 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.240509e-01 0.906 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.258546e-01 0.900 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.260098e-01 0.900 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.260098e-01 0.900 0 0
TCR signaling R-HSA-202403 1.260098e-01 0.900 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.266375e-01 0.897 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.295936e-01 0.639 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.295936e-01 0.639 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.295936e-01 0.639 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.295936e-01 0.639 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.295936e-01 0.639 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.295936e-01 0.639 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.295936e-01 0.639 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.295936e-01 0.639 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.295936e-01 0.639 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.295936e-01 0.639 0 0
Hereditary fructose intolerance R-HSA-5657560 2.295936e-01 0.639 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.295936e-01 0.639 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.295936e-01 0.639 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.295936e-01 0.639 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.295936e-01 0.639 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.295936e-01 0.639 0 0
MET interacts with TNS proteins R-HSA-8875513 1.393029e-01 0.856 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.393029e-01 0.856 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.393029e-01 0.856 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.393029e-01 0.856 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.393029e-01 0.856 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.849037e-01 0.733 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.849037e-01 0.733 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.849037e-01 0.733 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.849037e-01 0.733 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.849037e-01 0.733 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.437839e-01 0.842 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.437839e-01 0.842 0 0
Disinhibition of SNARE formation R-HSA-114516 1.437839e-01 0.842 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.322244e-01 0.634 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.322244e-01 0.634 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.322244e-01 0.634 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.322244e-01 0.634 0 0
Type I hemidesmosome assembly R-HSA-446107 1.748563e-01 0.757 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 1.349674e-01 0.870 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.349674e-01 0.870 0 0
Lipophagy R-HSA-9613354 2.075769e-01 0.683 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.427676e-01 0.845 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.427676e-01 0.845 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.839145e-01 0.735 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.839145e-01 0.735 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.839145e-01 0.735 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.631070e-01 0.788 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.292771e-01 0.888 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.845226e-01 0.734 0 0
Notch-HLH transcription pathway R-HSA-350054 1.628765e-01 0.788 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.628765e-01 0.788 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.444250e-01 0.840 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.376232e-01 0.624 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.068939e-01 0.684 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.770791e-01 0.752 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.770791e-01 0.752 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.523515e-01 0.817 0 0
G protein gated Potassium channels R-HSA-1296059 2.214366e-01 0.655 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 2.214366e-01 0.655 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 2.214366e-01 0.655 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.539951e-01 0.595 0 0
HIV Transcription Elongation R-HSA-167169 1.661020e-01 0.780 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.661020e-01 0.780 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.661020e-01 0.780 0 0
Dual incision in TC-NER R-HSA-6782135 1.601830e-01 0.795 0 0
G alpha (z) signalling events R-HSA-418597 2.057374e-01 0.687 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.877485e-01 0.726 0 0
Signaling by SCF-KIT R-HSA-1433557 2.264002e-01 0.645 0 0
DNA Damage Bypass R-HSA-73893 2.157079e-01 0.666 0 0
Translesion Synthesis by POLH R-HSA-110320 2.068939e-01 0.684 0 0
Integrin signaling R-HSA-354192 2.503332e-01 0.601 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.804134e-01 0.744 0 0
Integration of provirus R-HSA-162592 1.349674e-01 0.870 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.422573e-01 0.847 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.523515e-01 0.817 0 0
G-protein activation R-HSA-202040 2.539951e-01 0.595 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.285106e-01 0.641 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.849037e-01 0.733 0 0
Regulation of CDH11 function R-HSA-9762292 2.415137e-01 0.617 0 0
PI3K/AKT activation R-HSA-198203 2.415137e-01 0.617 0 0
Translesion synthesis by REV1 R-HSA-110312 2.376232e-01 0.624 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.718612e-01 0.765 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.770791e-01 0.752 0 0
Interleukin-17 signaling R-HSA-448424 1.478715e-01 0.830 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.587403e-01 0.799 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.944855e-01 0.711 0 0
Proteasome assembly R-HSA-9907900 1.477007e-01 0.831 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.539951e-01 0.595 0 0
Budding and maturation of HIV virion R-HSA-162588 2.125374e-01 0.673 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.285106e-01 0.641 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.423473e-01 0.616 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.748563e-01 0.757 0 0
Repression of WNT target genes R-HSA-4641265 1.587403e-01 0.799 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.587403e-01 0.799 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.845226e-01 0.734 0 0
Ca2+ pathway R-HSA-4086398 1.794440e-01 0.746 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.816171e-01 0.741 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.523515e-01 0.817 0 0
Heme signaling R-HSA-9707616 2.092500e-01 0.679 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.295936e-01 0.639 0 0
NADE modulates death signalling R-HSA-205025 1.849037e-01 0.733 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.281180e-01 0.892 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.631070e-01 0.788 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.478715e-01 0.830 0 0
Platelet degranulation R-HSA-114608 2.369830e-01 0.625 0 0
Activation of BH3-only proteins R-HSA-114452 1.944855e-01 0.711 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.877485e-01 0.726 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.877485e-01 0.726 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.877485e-01 0.726 0 0
Glycogen metabolism R-HSA-8982491 1.661020e-01 0.780 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.195518e-01 0.658 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.839145e-01 0.735 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.068939e-01 0.684 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.389456e-01 0.622 0 0
Adaptive Immune System R-HSA-1280218 1.396774e-01 0.855 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.952558e-01 0.709 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.105964e-01 0.677 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.876657e-01 0.727 0 0
Neurexins and neuroligins R-HSA-6794361 1.667112e-01 0.778 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.322244e-01 0.634 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.748563e-01 0.757 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.075769e-01 0.683 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.384131e-01 0.623 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.603293e-01 0.795 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.503332e-01 0.601 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.180098e-01 0.662 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.295936e-01 0.639 0 0
Inhibition of PKR R-HSA-169131 2.295936e-01 0.639 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.393029e-01 0.856 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.849037e-01 0.733 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.437839e-01 0.842 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.839145e-01 0.735 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.376232e-01 0.624 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.603748e-01 0.795 0 0
Interleukin-1 signaling R-HSA-9020702 2.180098e-01 0.662 0 0
Regulated Necrosis R-HSA-5218859 1.996419e-01 0.700 0 0
Netrin-1 signaling R-HSA-373752 1.477007e-01 0.831 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.450199e-01 0.839 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.423473e-01 0.616 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.391939e-01 0.621 0 0
Signaling by Hedgehog R-HSA-5358351 2.260883e-01 0.646 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.437839e-01 0.842 0 0
Glycogen storage diseases R-HSA-3229121 1.631070e-01 0.788 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.376232e-01 0.624 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.423473e-01 0.616 0 0
Hedgehog 'on' state R-HSA-5632684 1.580433e-01 0.801 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.375197e-01 0.624 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.849037e-01 0.733 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.587403e-01 0.799 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.587403e-01 0.799 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.450199e-01 0.839 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.566801e-01 0.805 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.539951e-01 0.595 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.264002e-01 0.645 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.539951e-01 0.595 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.415137e-01 0.617 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.503332e-01 0.601 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.427676e-01 0.845 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.539951e-01 0.595 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.270860e-01 0.896 1 0
Syndecan interactions R-HSA-3000170 1.816171e-01 0.741 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.545775e-01 0.811 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.587403e-01 0.799 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.587403e-01 0.799 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.075769e-01 0.683 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.279168e-01 0.893 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.328979e-01 0.876 0 0
Sensory processing of sound R-HSA-9659379 1.716988e-01 0.765 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.281180e-01 0.892 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.603293e-01 0.795 0 0
SARS-CoV Infections R-HSA-9679506 1.620483e-01 0.790 0 0
IRE1alpha activates chaperones R-HSA-381070 2.512353e-01 0.600 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.195518e-01 0.658 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.556690e-01 0.592 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.556690e-01 0.592 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.592472e-01 0.586 0 0
Somitogenesis R-HSA-9824272 2.592472e-01 0.586 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.616025e-01 0.582 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.637947e-01 0.579 0 0
Signaling by MET R-HSA-6806834 2.641560e-01 0.578 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.657326e-01 0.576 0 0
Translesion synthesis by POLI R-HSA-5656121 2.657326e-01 0.576 0 0
Activation of SMO R-HSA-5635838 2.657326e-01 0.576 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.657326e-01 0.576 0 0
Regulation of BACH1 activity R-HSA-9708530 2.657326e-01 0.576 0 0
Generic Transcription Pathway R-HSA-212436 2.673283e-01 0.573 0 0
Mitochondrial biogenesis R-HSA-1592230 2.698830e-01 0.569 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.699488e-01 0.569 0 0
FOXO-mediated transcription R-HSA-9614085 2.741428e-01 0.562 0 0
Immune System R-HSA-168256 2.757272e-01 0.560 1 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.762625e-01 0.559 0 0
Bicarbonate transporters R-HSA-425381 2.762625e-01 0.559 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.764432e-01 0.558 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.784655e-01 0.555 0 0
Assembly Of The HIV Virion R-HSA-175474 2.784655e-01 0.555 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.784655e-01 0.555 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.784655e-01 0.555 0 0
HCMV Late Events R-HSA-9610379 2.785683e-01 0.555 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.801634e-01 0.553 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.801634e-01 0.553 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.801634e-01 0.553 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.801634e-01 0.553 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.801634e-01 0.553 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.801634e-01 0.553 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.825410e-01 0.549 0 0
Telomere Extension By Telomerase R-HSA-171319 2.857294e-01 0.544 0 0
Pyroptosis R-HSA-5620971 2.857294e-01 0.544 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.857294e-01 0.544 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.899550e-01 0.538 0 0
Signal amplification R-HSA-392518 2.899550e-01 0.538 0 0
Gap junction assembly R-HSA-190861 2.899550e-01 0.538 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.899550e-01 0.538 0 0
Signaling by NOTCH2 R-HSA-1980145 2.899550e-01 0.538 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.916735e-01 0.535 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.916735e-01 0.535 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.916735e-01 0.535 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.923235e-01 0.534 0 0
Transcription of the HIV genome R-HSA-167172 2.928791e-01 0.533 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.934811e-01 0.532 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.935574e-01 0.532 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.935574e-01 0.532 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.944019e-01 0.531 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.944019e-01 0.531 0 0
Translesion synthesis by POLK R-HSA-5655862 2.944019e-01 0.531 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.944019e-01 0.531 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.944019e-01 0.531 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.944019e-01 0.531 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.997253e-01 0.523 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.033768e-01 0.518 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.033768e-01 0.518 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.033768e-01 0.518 0 0
Signaling by KIT in disease R-HSA-9669938 3.033768e-01 0.518 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.080211e-01 0.511 0 0
Platelet calcium homeostasis R-HSA-418360 3.080211e-01 0.511 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.080211e-01 0.511 0 0
PERK regulates gene expression R-HSA-381042 3.102846e-01 0.508 1 1
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.102846e-01 0.508 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.110148e-01 0.507 0 0
Gluconeogenesis R-HSA-70263 3.110148e-01 0.507 0 0
Translation of Structural Proteins R-HSA-9683701 3.111113e-01 0.507 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.114530e-01 0.507 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.114530e-01 0.507 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.114530e-01 0.507 0 0
Downstream TCR signaling R-HSA-202424 3.154367e-01 0.501 0 0
Death Receptor Signaling R-HSA-73887 3.202062e-01 0.495 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.234340e-01 0.490 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.234340e-01 0.490 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.234340e-01 0.490 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.238010e-01 0.490 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.238010e-01 0.490 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.238010e-01 0.490 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.238010e-01 0.490 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.238010e-01 0.490 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.238010e-01 0.490 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.238010e-01 0.490 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.238010e-01 0.490 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.238010e-01 0.490 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.238010e-01 0.490 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.238010e-01 0.490 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.238010e-01 0.490 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.238010e-01 0.490 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.238010e-01 0.490 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.238010e-01 0.490 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.238010e-01 0.490 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.253772e-01 0.488 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.253772e-01 0.488 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.278625e-01 0.484 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.278625e-01 0.484 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.278625e-01 0.484 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.278625e-01 0.484 0 0
CREB phosphorylation R-HSA-199920 3.278625e-01 0.484 0 0
Neurofascin interactions R-HSA-447043 3.278625e-01 0.484 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.278625e-01 0.484 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.286028e-01 0.483 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.301365e-01 0.481 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.305944e-01 0.481 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.305944e-01 0.481 0 0
G1/S-Specific Transcription R-HSA-69205 3.308711e-01 0.480 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.308711e-01 0.480 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.337532e-01 0.477 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.467522e-01 0.460 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.467522e-01 0.460 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.467522e-01 0.460 0 0
Signaling by LTK R-HSA-9842663 3.467522e-01 0.460 0 0
TBC/RABGAPs R-HSA-8854214 3.493469e-01 0.457 0 0
PKA activation R-HSA-163615 3.526428e-01 0.453 0 0
Apoptotic factor-mediated response R-HSA-111471 3.526428e-01 0.453 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.526428e-01 0.453 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.540217e-01 0.451 0 0
MET promotes cell motility R-HSA-8875878 3.725513e-01 0.429 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.725513e-01 0.429 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.725513e-01 0.429 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.746639e-01 0.426 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.746639e-01 0.426 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.746639e-01 0.426 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.746639e-01 0.426 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.746639e-01 0.426 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.746639e-01 0.426 0 0
DNA strand elongation R-HSA-69190 3.762395e-01 0.425 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.762395e-01 0.425 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.762395e-01 0.425 0 0
ABC-family proteins mediated transport R-HSA-382556 3.781712e-01 0.422 0 0
Tight junction interactions R-HSA-420029 3.795175e-01 0.421 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.795175e-01 0.421 0 0
Rap1 signalling R-HSA-392517 3.818552e-01 0.418 0 0
The NLRP3 inflammasome R-HSA-844456 3.818552e-01 0.418 0 0
Maturation of nucleoprotein R-HSA-9694631 3.818552e-01 0.418 0 0
Interleukin-6 signaling R-HSA-1059683 3.818659e-01 0.418 0 0
Maturation of nucleoprotein R-HSA-9683610 3.818659e-01 0.418 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.818659e-01 0.418 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.831704e-01 0.417 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.881181e-01 0.411 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.937304e-01 0.405 0 0
Nuclear RNA decay R-HSA-9930044 3.991456e-01 0.399 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.991456e-01 0.399 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.991456e-01 0.399 0 0
Iron uptake and transport R-HSA-917937 3.996865e-01 0.398 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.049801e-01 0.393 0 0
Infectious disease R-HSA-5663205 4.059553e-01 0.392 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.062827e-01 0.391 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.064933e-01 0.391 0 0
Signalling to ERK5 R-HSA-198765 4.064933e-01 0.391 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 4.064933e-01 0.391 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.064933e-01 0.391 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.064933e-01 0.391 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.064933e-01 0.391 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.064933e-01 0.391 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.072727e-01 0.390 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.075792e-01 0.390 0 0
Signaling by TGFBR3 R-HSA-9839373 4.075792e-01 0.390 0 0
Protein hydroxylation R-HSA-9629569 4.109128e-01 0.386 0 0
Aquaporin-mediated transport R-HSA-445717 4.123702e-01 0.385 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.123702e-01 0.385 0 0
Signaling by NTRKs R-HSA-166520 4.136835e-01 0.383 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.165386e-01 0.380 0 0
Signal regulatory protein family interactions R-HSA-391160 4.165386e-01 0.380 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.165386e-01 0.380 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.200742e-01 0.377 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.200742e-01 0.377 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.200742e-01 0.377 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.200742e-01 0.377 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.200742e-01 0.377 0 0
Co-stimulation by ICOS R-HSA-9927354 4.200742e-01 0.377 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.220029e-01 0.375 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.246629e-01 0.372 0 0
Mitochondrial protein import R-HSA-1268020 4.295847e-01 0.367 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.303073e-01 0.366 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.303073e-01 0.366 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.303073e-01 0.366 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.303073e-01 0.366 0 0
Potential therapeutics for SARS R-HSA-9679191 4.358699e-01 0.361 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.396718e-01 0.357 0 0
Transmission across Chemical Synapses R-HSA-112315 4.443141e-01 0.352 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.447382e-01 0.352 0 0
ABC transporter disorders R-HSA-5619084 4.464861e-01 0.350 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.483343e-01 0.348 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.505522e-01 0.346 0 0
p38MAPK events R-HSA-171007 4.505522e-01 0.346 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.505522e-01 0.346 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.505522e-01 0.346 0 0
Inositol phosphate metabolism R-HSA-1483249 4.510538e-01 0.346 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.536676e-01 0.343 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.554042e-01 0.342 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.554042e-01 0.342 0 0
NRAGE signals death through JNK R-HSA-193648 4.557649e-01 0.341 0 0
Intra-Golgi traffic R-HSA-6811438 4.561971e-01 0.341 0 0
Metabolism of proteins R-HSA-392499 4.583012e-01 0.339 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.637339e-01 0.334 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.637339e-01 0.334 0 0
Calcineurin activates NFAT R-HSA-2025928 4.637339e-01 0.334 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.637339e-01 0.334 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 4.637339e-01 0.334 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.637339e-01 0.334 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.637339e-01 0.334 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.637339e-01 0.334 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.637339e-01 0.334 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.637339e-01 0.334 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.637339e-01 0.334 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.637339e-01 0.334 0 0
Signalling to ERKs R-HSA-187687 4.672833e-01 0.330 0 0
Axonal growth stimulation R-HSA-209563 4.790773e-01 0.320 0 0
MET activates PTPN11 R-HSA-8865999 4.790773e-01 0.320 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.790773e-01 0.320 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.790773e-01 0.320 0 0
Intracellular oxygen transport R-HSA-8981607 4.790773e-01 0.320 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.790773e-01 0.320 0 0
Histamine receptors R-HSA-390650 4.790773e-01 0.320 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.790773e-01 0.320 0 0
DARPP-32 events R-HSA-180024 4.801842e-01 0.319 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.801842e-01 0.319 0 0
Glucagon-type ligand receptors R-HSA-420092 4.801842e-01 0.319 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.801842e-01 0.319 0 0
Killing mechanisms R-HSA-9664420 4.837242e-01 0.315 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.837242e-01 0.315 0 0
Prolonged ERK activation events R-HSA-169893 4.837242e-01 0.315 0 0
RUNX2 regulates bone development R-HSA-8941326 4.895747e-01 0.310 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.957961e-01 0.305 0 0
Signaling by FGFR4 R-HSA-5654743 4.972564e-01 0.303 0 0
DAP12 signaling R-HSA-2424491 5.045689e-01 0.297 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.053921e-01 0.296 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.053921e-01 0.296 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.053921e-01 0.296 0 0
Interleukin-27 signaling R-HSA-9020956 5.053921e-01 0.296 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.053921e-01 0.296 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.053921e-01 0.296 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.053921e-01 0.296 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.053921e-01 0.296 0 0
Extension of Telomeres R-HSA-180786 5.095011e-01 0.293 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.159051e-01 0.287 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.159051e-01 0.287 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.226286e-01 0.282 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.229506e-01 0.282 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.229506e-01 0.282 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.284885e-01 0.277 0 0
Downstream signal transduction R-HSA-186763 5.284885e-01 0.277 0 0
Ion channel transport R-HSA-983712 5.357283e-01 0.271 0 0
Signaling by FGFR3 R-HSA-5654741 5.372859e-01 0.270 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.405679e-01 0.267 0 0
Rab regulation of trafficking R-HSA-9007101 5.407317e-01 0.267 0 0
Alternative complement activation R-HSA-173736 5.427883e-01 0.265 0 0
HCN channels R-HSA-1296061 5.427883e-01 0.265 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.427883e-01 0.265 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.427883e-01 0.265 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.427883e-01 0.265 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.427883e-01 0.265 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.427883e-01 0.265 0 0
Formation of the posterior neural plate R-HSA-9832991 5.448855e-01 0.264 0 0
vRNP Assembly R-HSA-192905 5.448855e-01 0.264 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.448855e-01 0.264 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.448855e-01 0.264 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.469758e-01 0.262 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.469758e-01 0.262 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.469758e-01 0.262 1 1
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.469758e-01 0.262 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.493839e-01 0.260 0 0
Toll-like Receptor Cascades R-HSA-168898 5.556064e-01 0.255 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.568120e-01 0.254 0 0
Diseases of DNA repair R-HSA-9675135 5.568120e-01 0.254 0 0
Regulation of insulin secretion R-HSA-422356 5.585580e-01 0.253 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.615027e-01 0.251 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.615027e-01 0.251 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.746935e-01 0.241 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.746935e-01 0.241 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.750262e-01 0.240 0 0
TGFBR3 expression R-HSA-9839394 5.750262e-01 0.240 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.750262e-01 0.240 0 0
Laminin interactions R-HSA-3000157 5.750262e-01 0.240 0 0
Generation of second messenger molecules R-HSA-202433 5.751170e-01 0.240 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.759649e-01 0.240 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.768448e-01 0.239 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.768448e-01 0.239 0 0
Polo-like kinase mediated events R-HSA-156711 5.768448e-01 0.239 0 0
PKA activation in glucagon signalling R-HSA-164378 5.768448e-01 0.239 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.821204e-01 0.235 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.821204e-01 0.235 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.821204e-01 0.235 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.821204e-01 0.235 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.821204e-01 0.235 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.821204e-01 0.235 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.821204e-01 0.235 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.825485e-01 0.235 0 0
Intraflagellar transport R-HSA-5620924 5.947139e-01 0.226 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.948474e-01 0.226 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.953478e-01 0.225 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.987104e-01 0.223 0 0
IRS activation R-HSA-74713 5.987104e-01 0.223 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.987104e-01 0.223 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.987104e-01 0.223 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.987104e-01 0.223 0 0
Defective F9 activation R-HSA-9673221 5.987104e-01 0.223 0 0
Activation of C3 and C5 R-HSA-174577 5.987104e-01 0.223 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.987104e-01 0.223 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.987104e-01 0.223 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.987104e-01 0.223 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.987104e-01 0.223 0 0
Suppression of autophagy R-HSA-9636569 5.987104e-01 0.223 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.987104e-01 0.223 0 0
Inositol transporters R-HSA-429593 5.987104e-01 0.223 0 0
NrCAM interactions R-HSA-447038 5.987104e-01 0.223 0 0
Reelin signalling pathway R-HSA-8866376 5.987104e-01 0.223 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.987104e-01 0.223 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.987104e-01 0.223 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.987104e-01 0.223 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.987104e-01 0.223 0 0
MET activates PTK2 signaling R-HSA-8874081 5.998209e-01 0.222 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.998209e-01 0.222 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.053545e-01 0.218 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.054447e-01 0.218 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.054447e-01 0.218 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.054447e-01 0.218 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.054447e-01 0.218 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.054447e-01 0.218 0 0
Neuronal System R-HSA-112316 6.065656e-01 0.217 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.130315e-01 0.213 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.137544e-01 0.212 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.151006e-01 0.211 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.151006e-01 0.211 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.170586e-01 0.210 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.170586e-01 0.210 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.170586e-01 0.210 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.170586e-01 0.210 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.170586e-01 0.210 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.170586e-01 0.210 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.170586e-01 0.210 0 0
Interleukin-35 Signalling R-HSA-8984722 6.170586e-01 0.210 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.170586e-01 0.210 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.170586e-01 0.210 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.184011e-01 0.209 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.184011e-01 0.209 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.184011e-01 0.209 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.237234e-01 0.205 0 0
Cristae formation R-HSA-8949613 6.237234e-01 0.205 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.237234e-01 0.205 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.237234e-01 0.205 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.327303e-01 0.199 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.327303e-01 0.199 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.327303e-01 0.199 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.327303e-01 0.199 0 0
Activation of GABAB receptors R-HSA-991365 6.342779e-01 0.198 0 0
GABA B receptor activation R-HSA-977444 6.342779e-01 0.198 0 0
Cardiac conduction R-HSA-5576891 6.370537e-01 0.196 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.392794e-01 0.194 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.467003e-01 0.189 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.467003e-01 0.189 0 0
Inflammasomes R-HSA-622312 6.467003e-01 0.189 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.477954e-01 0.189 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.477954e-01 0.189 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.477954e-01 0.189 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.477954e-01 0.189 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.477954e-01 0.189 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.477954e-01 0.189 0 0
Cam-PDE 1 activation R-HSA-111957 6.477954e-01 0.189 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.477954e-01 0.189 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.477954e-01 0.189 0 0
Synthesis of PS R-HSA-1483101 6.477954e-01 0.189 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.477954e-01 0.189 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.477954e-01 0.189 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.477954e-01 0.189 0 0
Relaxin receptors R-HSA-444821 6.477954e-01 0.189 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.477954e-01 0.189 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.477954e-01 0.189 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.497047e-01 0.187 0 0
Formation of axial mesoderm R-HSA-9796292 6.497047e-01 0.187 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.497047e-01 0.187 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.497047e-01 0.187 0 0
Frs2-mediated activation R-HSA-170968 6.497047e-01 0.187 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.586750e-01 0.181 0 0
ERK/MAPK targets R-HSA-198753 6.586750e-01 0.181 0 0
Signalling to RAS R-HSA-167044 6.586750e-01 0.181 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.586750e-01 0.181 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.586750e-01 0.181 0 0
GPVI-mediated activation cascade R-HSA-114604 6.593330e-01 0.181 0 0
RAB geranylgeranylation R-HSA-8873719 6.608847e-01 0.180 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.651711e-01 0.177 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.678586e-01 0.175 0 0
mRNA Capping R-HSA-72086 6.687281e-01 0.175 0 0
Translation of Structural Proteins R-HSA-9694635 6.692203e-01 0.174 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.712691e-01 0.173 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.723922e-01 0.172 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.774471e-01 0.169 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.774471e-01 0.169 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.800967e-01 0.167 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.800967e-01 0.167 0 0
Malate-aspartate shuttle R-HSA-9856872 6.800967e-01 0.167 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.800967e-01 0.167 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.800967e-01 0.167 0 0
HDL assembly R-HSA-8963896 6.800967e-01 0.167 0 0
Integrin cell surface interactions R-HSA-216083 6.830089e-01 0.166 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.832686e-01 0.165 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.832686e-01 0.165 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.832686e-01 0.165 0 0
Ribavirin ADME R-HSA-9755088 6.832686e-01 0.165 0 0
Serine metabolism R-HSA-977347 6.832686e-01 0.165 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.876148e-01 0.163 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.897927e-01 0.161 0 0
Chylomicron clearance R-HSA-8964026 6.908790e-01 0.161 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.908790e-01 0.161 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.908790e-01 0.161 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.908790e-01 0.161 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.908790e-01 0.161 0 0
Lactose synthesis R-HSA-5653890 6.908790e-01 0.161 0 0
NADPH regeneration R-HSA-389542 6.908790e-01 0.161 0 0
CREB3 factors activate genes R-HSA-8874211 6.908790e-01 0.161 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.973176e-01 0.157 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.050774e-01 0.152 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.050774e-01 0.152 0 0
FGFR2 alternative splicing R-HSA-6803529 7.065150e-01 0.151 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.065150e-01 0.151 0 0
LDL clearance R-HSA-8964038 7.065150e-01 0.151 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.082976e-01 0.150 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.082976e-01 0.150 0 0
Protein lipoylation R-HSA-9857492 7.082976e-01 0.150 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.082976e-01 0.150 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.082976e-01 0.150 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.082976e-01 0.150 0 0
Formation of the anterior neural plate R-HSA-9823739 7.082976e-01 0.150 0 0
Signaling by FGFR2 R-HSA-5654738 7.095244e-01 0.149 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.098882e-01 0.149 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.143773e-01 0.146 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.151767e-01 0.146 0 0
RAS processing R-HSA-9648002 7.151767e-01 0.146 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.212386e-01 0.142 0 0
TNF signaling R-HSA-75893 7.275876e-01 0.138 0 0
Signaling by FGFR1 R-HSA-5654736 7.275876e-01 0.138 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.284296e-01 0.138 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.284296e-01 0.138 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.286945e-01 0.137 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.286945e-01 0.137 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.286945e-01 0.137 0 0
SOS-mediated signalling R-HSA-112412 7.286945e-01 0.137 0 0
PTK6 Expression R-HSA-8849473 7.286945e-01 0.137 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.286945e-01 0.137 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.286945e-01 0.137 0 0
VLDL clearance R-HSA-8964046 7.286945e-01 0.137 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.286945e-01 0.137 0 0
Netrin mediated repulsion signals R-HSA-418886 7.286945e-01 0.137 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.286945e-01 0.137 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.322755e-01 0.135 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.322755e-01 0.135 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.322755e-01 0.135 0 0
Diseases of Immune System R-HSA-5260271 7.322755e-01 0.135 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.343885e-01 0.134 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.343885e-01 0.134 0 0
Attachment and Entry R-HSA-9678110 7.343885e-01 0.134 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.343885e-01 0.134 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.343885e-01 0.134 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.343885e-01 0.134 0 0
NGF-stimulated transcription R-HSA-9031628 7.367729e-01 0.133 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.465606e-01 0.127 0 0
Disease R-HSA-1643685 7.468770e-01 0.127 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.480051e-01 0.126 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.490377e-01 0.125 0 0
Complex III assembly R-HSA-9865881 7.490377e-01 0.125 0 0
Interleukin-6 family signaling R-HSA-6783589 7.490377e-01 0.125 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.490377e-01 0.125 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.490377e-01 0.125 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.584635e-01 0.120 0 0
Fibronectin matrix formation R-HSA-1566977 7.584635e-01 0.120 0 0
Galactose catabolism R-HSA-70370 7.584635e-01 0.120 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.584635e-01 0.120 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.584635e-01 0.120 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.618859e-01 0.118 0 0
phospho-PLA2 pathway R-HSA-111995 7.618859e-01 0.118 0 0
MET receptor recycling R-HSA-8875656 7.618859e-01 0.118 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.618859e-01 0.118 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.618859e-01 0.118 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.618859e-01 0.118 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.618859e-01 0.118 0 0
Fructose biosynthesis R-HSA-5652227 7.618859e-01 0.118 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.618859e-01 0.118 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.618859e-01 0.118 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.618859e-01 0.118 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.618859e-01 0.118 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.618859e-01 0.118 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.642041e-01 0.117 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.644036e-01 0.117 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.660038e-01 0.116 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.683726e-01 0.114 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.683726e-01 0.114 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.688187e-01 0.114 0 0
Parasitic Infection Pathways R-HSA-9824443 7.749895e-01 0.111 0 0
Leishmania infection R-HSA-9658195 7.749895e-01 0.111 0 0
The phototransduction cascade R-HSA-2514856 7.796279e-01 0.108 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.806254e-01 0.108 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.806254e-01 0.108 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.806254e-01 0.108 0 0
Specification of primordial germ cells R-HSA-9827857 7.806254e-01 0.108 0 0
eNOS activation R-HSA-203615 7.806947e-01 0.108 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.806947e-01 0.108 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.864737e-01 0.104 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.864737e-01 0.104 0 0
TRP channels R-HSA-3295583 7.864737e-01 0.104 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.910184e-01 0.102 0 0
ARMS-mediated activation R-HSA-170984 7.910184e-01 0.102 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.910184e-01 0.102 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.910184e-01 0.102 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.910184e-01 0.102 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.910184e-01 0.102 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.910184e-01 0.102 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.910184e-01 0.102 0 0
Interleukin-1 processing R-HSA-448706 7.910184e-01 0.102 0 0
PI Metabolism R-HSA-1483255 7.980892e-01 0.098 0 0
Pyruvate metabolism R-HSA-70268 8.008502e-01 0.096 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.009817e-01 0.096 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.009817e-01 0.096 0 0
Mismatch Repair R-HSA-5358508 8.009817e-01 0.096 0 0
Tie2 Signaling R-HSA-210993 8.009817e-01 0.096 0 0
Insulin processing R-HSA-264876 8.033854e-01 0.095 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.039476e-01 0.095 0 0
DAP12 interactions R-HSA-2172127 8.065606e-01 0.093 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.105801e-01 0.091 0 0
Triglyceride catabolism R-HSA-163560 8.105801e-01 0.091 0 0
Neddylation R-HSA-8951664 8.106405e-01 0.091 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.165881e-01 0.088 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.165881e-01 0.088 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.165881e-01 0.088 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.165881e-01 0.088 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.165881e-01 0.088 0 0
Signal attenuation R-HSA-74749 8.165881e-01 0.088 0 0
CASP4 inflammasome assembly R-HSA-9948001 8.165881e-01 0.088 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.165881e-01 0.088 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.165881e-01 0.088 0 0
Maturation of spike protein R-HSA-9683686 8.165881e-01 0.088 0 0
Signaling by Leptin R-HSA-2586552 8.165881e-01 0.088 0 0
Formation of apoptosome R-HSA-111458 8.165881e-01 0.088 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.191560e-01 0.087 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.196425e-01 0.086 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.196425e-01 0.086 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.196425e-01 0.086 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.196425e-01 0.086 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.196425e-01 0.086 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.196425e-01 0.086 0 0
Specification of the neural plate border R-HSA-9834899 8.196425e-01 0.086 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.312779e-01 0.080 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.312779e-01 0.080 0 0
Signaling by Erythropoietin R-HSA-9006335 8.338360e-01 0.079 0 0
Post-translational protein modification R-HSA-597592 8.338946e-01 0.079 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.367178e-01 0.077 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.367178e-01 0.077 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.367178e-01 0.077 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.367178e-01 0.077 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.367178e-01 0.077 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.367178e-01 0.077 0 0
Creatine metabolism R-HSA-71288 8.367178e-01 0.077 0 0
Elastic fibre formation R-HSA-1566948 8.370497e-01 0.077 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.370497e-01 0.077 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.389999e-01 0.076 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.390306e-01 0.076 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.390306e-01 0.076 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.390306e-01 0.076 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.390306e-01 0.076 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.390306e-01 0.076 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.390306e-01 0.076 0 0
Signaling by APC mutants R-HSA-4839744 8.390306e-01 0.076 0 0
vRNA Synthesis R-HSA-192814 8.390306e-01 0.076 0 0
Chylomicron assembly R-HSA-8963888 8.390306e-01 0.076 0 0
Suppression of apoptosis R-HSA-9635465 8.390306e-01 0.076 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.390306e-01 0.076 0 0
Interleukin-2 signaling R-HSA-9020558 8.390306e-01 0.076 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.390306e-01 0.076 0 0
Platelet homeostasis R-HSA-418346 8.406393e-01 0.075 0 0
Interleukin-1 family signaling R-HSA-446652 8.410251e-01 0.075 0 0
Integration of energy metabolism R-HSA-163685 8.422691e-01 0.075 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.474779e-01 0.072 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.474779e-01 0.072 0 0
Lagging Strand Synthesis R-HSA-69186 8.523163e-01 0.069 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.523163e-01 0.069 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.523163e-01 0.069 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 8.523163e-01 0.069 0 0
Stimuli-sensing channels R-HSA-2672351 8.555980e-01 0.068 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.560251e-01 0.068 0 0
ERKs are inactivated R-HSA-202670 8.587281e-01 0.066 0 0
Signaling by AXIN mutants R-HSA-4839735 8.587281e-01 0.066 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.587281e-01 0.066 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.587281e-01 0.066 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.587281e-01 0.066 0 0
Sodium/Calcium exchangers R-HSA-425561 8.587281e-01 0.066 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.587281e-01 0.066 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.587281e-01 0.066 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.588161e-01 0.066 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.588161e-01 0.066 0 0
Adipogenesis R-HSA-9843745 8.599647e-01 0.066 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.603481e-01 0.065 0 0
Interleukin-2 family signaling R-HSA-451927 8.603481e-01 0.065 0 0
Attachment and Entry R-HSA-9694614 8.665435e-01 0.062 0 0
Parasite infection R-HSA-9664407 8.677860e-01 0.062 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.677860e-01 0.062 0 0
Leishmania phagocytosis R-HSA-9664417 8.677860e-01 0.062 0 0
Peroxisomal protein import R-HSA-9033241 8.679443e-01 0.062 0 0
Regulation of beta-cell development R-HSA-186712 8.679443e-01 0.062 0 0
Mitochondrial protein degradation R-HSA-9837999 8.690403e-01 0.061 0 0
Azathioprine ADME R-HSA-9748787 8.729766e-01 0.059 0 0
Gastrulation R-HSA-9758941 8.750793e-01 0.058 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.760163e-01 0.057 0 0
Acetylation R-HSA-156582 8.760163e-01 0.057 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.760163e-01 0.057 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.760163e-01 0.057 0 0
Polymerase switching R-HSA-69091 8.760163e-01 0.057 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.760163e-01 0.057 0 0
Leading Strand Synthesis R-HSA-69109 8.760163e-01 0.057 0 0
Regulation of IFNG signaling R-HSA-877312 8.760163e-01 0.057 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.760163e-01 0.057 0 0
OAS antiviral response R-HSA-8983711 8.760163e-01 0.057 0 0
GABA receptor activation R-HSA-977443 8.765759e-01 0.057 0 0
Metabolism of polyamines R-HSA-351202 8.765759e-01 0.057 0 0
SLC transporter disorders R-HSA-5619102 8.782309e-01 0.056 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.795014e-01 0.056 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.795014e-01 0.056 0 0
Fructose metabolism R-HSA-5652084 8.795014e-01 0.056 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.795014e-01 0.056 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.807383e-01 0.055 0 0
HIV Transcription Initiation R-HSA-167161 8.807383e-01 0.055 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.807383e-01 0.055 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.807383e-01 0.055 0 0
COPII-mediated vesicle transport R-HSA-204005 8.809325e-01 0.055 0 0
Interferon gamma signaling R-HSA-877300 8.818925e-01 0.055 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.827066e-01 0.054 0 0
Cardiogenesis R-HSA-9733709 8.827066e-01 0.054 0 0
RSV-host interactions R-HSA-9833110 8.884700e-01 0.051 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.891946e-01 0.051 0 0
Potassium Channels R-HSA-1296071 8.891946e-01 0.051 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.899272e-01 0.051 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.899272e-01 0.051 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.903226e-01 0.050 0 0
Chylomicron remodeling R-HSA-8963901 8.911897e-01 0.050 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.911897e-01 0.050 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.911897e-01 0.050 0 0
Processing of SMDT1 R-HSA-8949664 8.911897e-01 0.050 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.911897e-01 0.050 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.911897e-01 0.050 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.922051e-01 0.050 0 0
Signaling by PDGF R-HSA-186797 8.924213e-01 0.049 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.927269e-01 0.049 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.927269e-01 0.049 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.927269e-01 0.049 0 0
Protein localization R-HSA-9609507 8.957658e-01 0.048 0 0
tRNA processing R-HSA-72306 8.976354e-01 0.047 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.984900e-01 0.046 0 0
Signaling by FGFR R-HSA-190236 9.011582e-01 0.045 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.019718e-01 0.045 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.019718e-01 0.045 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.019946e-01 0.045 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.019946e-01 0.045 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.021385e-01 0.045 0 0
Removal of the Flap Intermediate R-HSA-69166 9.045069e-01 0.044 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.045069e-01 0.044 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.045069e-01 0.044 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.045069e-01 0.044 0 0
Hydrolysis of LPC R-HSA-1483115 9.045069e-01 0.044 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.045069e-01 0.044 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.045069e-01 0.044 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.045069e-01 0.044 0 0
Zinc transporters R-HSA-435354 9.045069e-01 0.044 0 0
Signaling by FGFR in disease R-HSA-1226099 9.084527e-01 0.042 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.117101e-01 0.040 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.117101e-01 0.040 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.138699e-01 0.039 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.161950e-01 0.038 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.161950e-01 0.038 0 0
Biotin transport and metabolism R-HSA-196780 9.161950e-01 0.038 0 0
Protein repair R-HSA-5676934 9.161950e-01 0.038 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.161950e-01 0.038 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.161950e-01 0.038 0 0
Other semaphorin interactions R-HSA-416700 9.161950e-01 0.038 0 0
DNA Damage Reversal R-HSA-73942 9.161950e-01 0.038 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.205163e-01 0.036 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.205163e-01 0.036 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.205163e-01 0.036 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.205163e-01 0.036 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.234738e-01 0.035 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.255411e-01 0.034 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.264530e-01 0.033 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.264530e-01 0.033 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.264530e-01 0.033 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.264530e-01 0.033 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.264530e-01 0.033 0 0
Fructose catabolism R-HSA-70350 9.264530e-01 0.033 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.264530e-01 0.033 0 0
Atorvastatin ADME R-HSA-9754706 9.264530e-01 0.033 0 0
Virus Assembly and Release R-HSA-168268 9.264530e-01 0.033 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.267527e-01 0.033 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.284902e-01 0.032 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.284902e-01 0.032 0 0
Innate Immune System R-HSA-168249 9.297852e-01 0.032 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.350261e-01 0.029 0 0
Glycine degradation R-HSA-6783984 9.354560e-01 0.029 0 0
Heme assimilation R-HSA-9927020 9.354560e-01 0.029 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.354560e-01 0.029 0 0
Passive transport by Aquaporins R-HSA-432047 9.354560e-01 0.029 0 0
Synthesis of PG R-HSA-1483148 9.354560e-01 0.029 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.354560e-01 0.029 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.354560e-01 0.029 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.382363e-01 0.028 0 0
Pentose phosphate pathway R-HSA-71336 9.382363e-01 0.028 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.407862e-01 0.027 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.422231e-01 0.026 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.422231e-01 0.026 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.433573e-01 0.025 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.433573e-01 0.025 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.433573e-01 0.025 0 0
PI3K Cascade R-HSA-109704 9.435965e-01 0.025 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.453414e-01 0.024 0 0
Developmental Cell Lineages R-HSA-9734767 9.459998e-01 0.024 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.481105e-01 0.023 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.502918e-01 0.022 0 0
Platelet sensitization by LDL R-HSA-432142 9.502918e-01 0.022 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.502918e-01 0.022 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.502918e-01 0.022 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.534227e-01 0.021 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.535127e-01 0.021 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.535670e-01 0.021 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.563777e-01 0.019 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.563777e-01 0.019 0 0
Diseases of hemostasis R-HSA-9671793 9.563777e-01 0.019 0 0
HDL remodeling R-HSA-8964058 9.563777e-01 0.019 0 0
IGF1R signaling cascade R-HSA-2428924 9.571664e-01 0.019 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.574589e-01 0.019 0 0
Signaling by WNT in cancer R-HSA-4791275 9.582124e-01 0.019 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.605556e-01 0.017 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.617188e-01 0.017 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.617188e-01 0.017 0 0
Formation of definitive endoderm R-HSA-9823730 9.617188e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.617188e-01 0.017 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.617255e-01 0.017 0 0
Paracetamol ADME R-HSA-9753281 9.636532e-01 0.016 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.646829e-01 0.016 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.664062e-01 0.015 0 0
Abacavir metabolism R-HSA-2161541 9.664062e-01 0.015 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.664062e-01 0.015 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.664062e-01 0.015 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.664134e-01 0.015 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.664134e-01 0.015 0 0
Heme degradation R-HSA-189483 9.664134e-01 0.015 0 0
IRS-mediated signalling R-HSA-112399 9.696351e-01 0.013 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.699095e-01 0.013 0 0
Hyaluronan metabolism R-HSA-2142845 9.699095e-01 0.013 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.705199e-01 0.013 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.730532e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.730532e-01 0.012 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.730532e-01 0.012 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.730532e-01 0.012 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.730632e-01 0.012 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.741300e-01 0.011 0 0
Cellular hexose transport R-HSA-189200 9.741300e-01 0.011 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.741300e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.746868e-01 0.011 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.766125e-01 0.010 0 0
tRNA Aminoacylation R-HSA-379724 9.769059e-01 0.010 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.772983e-01 0.010 0 0
Formation of the ureteric bud R-HSA-9830674 9.772983e-01 0.010 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.772983e-01 0.010 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.772983e-01 0.010 0 0
Carnitine shuttle R-HSA-200425 9.772983e-01 0.010 0 0
Growth hormone receptor signaling R-HSA-982772 9.772983e-01 0.010 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.800787e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.800787e-01 0.009 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.806943e-01 0.008 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.806943e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.808615e-01 0.008 0 0
Hyaluronan degradation R-HSA-2160916 9.825187e-01 0.008 0 0
Formation of the nephric duct R-HSA-9830364 9.825187e-01 0.008 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.825187e-01 0.008 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.825187e-01 0.008 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.831989e-01 0.007 0 0
Insulin receptor signalling cascade R-HSA-74751 9.840778e-01 0.007 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.846599e-01 0.007 0 0
Urea cycle R-HSA-70635 9.846599e-01 0.007 0 0
Sphingolipid catabolism R-HSA-9845614 9.846599e-01 0.007 0 0
Abacavir ADME R-HSA-2161522 9.846599e-01 0.007 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.846599e-01 0.007 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.862145e-01 0.006 0 0
Maturation of spike protein R-HSA-9694548 9.862145e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.865390e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.866277e-01 0.006 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.881378e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.881881e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.882079e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.882079e-01 0.005 0 0
Neurotransmitter clearance R-HSA-112311 9.909050e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.910062e-01 0.004 0 0
Amine ligand-binding receptors R-HSA-375280 9.912418e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.913160e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.918346e-01 0.004 0 0
Metabolism of cofactors R-HSA-8978934 9.918346e-01 0.004 0 0
Cargo concentration in the ER R-HSA-5694530 9.920194e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.923984e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.931076e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.937867e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.937867e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.938554e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.943568e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.944615e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.949679e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.949732e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.950643e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.952691e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.958490e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.958915e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.960830e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.960898e-01 0.002 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.961065e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.963577e-01 0.002 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.963577e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.963678e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.968042e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.968042e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.968042e-01 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.968944e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.968944e-01 0.001 0 0
Signaling by Insulin receptor R-HSA-74752 9.970562e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.971483e-01 0.001 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.975397e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.975677e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.977441e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.978413e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.978413e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.978413e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.978413e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.978921e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.982899e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.986243e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.987025e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.988776e-01 0.000 0 0
Methylation R-HSA-156581 9.988776e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.988776e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.989855e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.990093e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.990153e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.990389e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.992321e-01 0.000 0 0
Kidney development R-HSA-9830369 9.994018e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994018e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994024e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.994166e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994689e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995221e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.995509e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.995509e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996286e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996614e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996705e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997406e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.997953e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.997953e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998396e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998424e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998513e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998618e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.998618e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998836e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998984e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999203e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999324e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999447e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999506e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999550e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999569e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999621e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999627e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999673e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999673e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999827e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999840e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999847e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999885e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999885e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999902e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999912e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999913e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999914e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999942e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999947e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999960e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999973e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999980e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999983e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999991e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999992e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999992e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999994e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999996e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways