MOS

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00170	S43	Sugiyama	AIP XAP2	GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI
O43707	S909	Sugiyama	ACTN4	PDAVPGALDyKsFStALyGEsDL__________________
O43707	Y878	Sugiyama	ACTN4	DKNFITAEELRRELPPDQAEyCIARMAPyQGPDAVPGALDy
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	Y263	Sugiyama	CALU	KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43852	Y47	Sugiyama	CALU	RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O75821	S28	Sugiyama	EIF3G EIF3S4	sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
P00338	S237	Sugiyama	LDHA PIG19	DLGtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVA
P00540	S25	Sugiyama	MOS	LALRPYLRSEFSPSVDARPCssPsELPAKLLLGATLPRAPR
P00540	S26	Sugiyama	MOS	ALRPYLRSEFSPSVDARPCssPsELPAKLLLGATLPRAPRL
P00540	S28	Sugiyama	MOS	RPYLRSEFSPSVDARPCssPsELPAKLLLGATLPRAPRLPR
P00558	S415	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GGGAsLELLEGKVLPGVDALsNI__________________
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187	S114	Sugiyama	ALPP PLAP	DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237	T85	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355	Y188	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900	S165	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08238	S160	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T85	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238	T89	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08670	S459	PSP	VIM	KRTLLIKtVEtRDGQVINEtsQHHDDLE_____________
P08670	T458	PSP	VIM	sKRTLLIKtVEtRDGQVINEtsQHHDDLE____________
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08758	S136	Sugiyama	ANXA5 ANX5 ENX2 PP4	sRtPEELRAIKQVyEEEyGssLEDDVVGDTSGYYQRMLVVL
P08758	T10	Sugiyama	ANXA5 ANX5 ENX2 PP4	___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P08758	T111	Sugiyama	ANXA5 ANX5 ENX2 PP4	yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P0DPH7	T73	Sugiyama	TUBA3C TUBA2	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7	T80	Sugiyama	TUBA3C TUBA2	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P10696	S111	Sugiyama	ALPG ALPPL ALPPL2	DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P10809	T105	Sugiyama	HSPD1 HSP60	DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK
P11142	S85	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P12814	Y859	Sugiyama	ACTN1	DKNyITMDELRRELPPDQAEyCIARMAPYTGPDSVPGALDY
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P17066	T47	Sugiyama	HSPA6 HSP70B'	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P22314	T233	Sugiyama	UBA1 A1S9T UBE1	GEQPLSAMVSMVTKDNPGVVtCLDEARHGFESGDFVSFSEV
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P23396	T242	Sugiyama	RPS3 OK/SW-cl.26	PIsEQKGGKPEPPAMPQPVPtA___________________
P25205	Y19	Sugiyama	MCM3	__MAGtVVLDDVELREAQRDyLDFLDDEEDQGIyQsKVREL
P25705	T64	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	QKtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARV
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P42224	Y170	Sugiyama	STAT1	KDKVMCIEHEIKsLEDLQDEyDFKCKTLQNREHETNGVAKS
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P48741	T47	Sugiyama	HSPA7 HSP70B	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49588	S188	Sugiyama	AARS1 AARS	PGNMKDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDD
P50502	S181	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60228	S442	Sugiyama	EIF3E EIF3S6 INT6	IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60228	Y445	Sugiyama	EIF3E EIF3S6 INT6	KLNQNSRSEAPNWAtQDsGFy____________________
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q02750	S222	SIGNOR	MAP2K1 MEK1 PRKMK1	GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06830	S32	Sugiyama	PRDX1 PAGA PAGB TDPX2	APNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTFVC
Q06830	Y116	Sugiyama	PRDX1 PAGA PAGB TDPX2	GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q14568	S165	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14677	S164	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	RLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKW
Q15293	Y278	Sugiyama	RCN1 RCN	LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16576	S163	Sugiyama	RBBP7 RBAP46	tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q16658	Y493	Sugiyama	FSCN1 FAN1 HSN SNL	DHAGVLKASAEtVDPAsLWEy____________________
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PCE3	T173	Sugiyama	PGM2L1 BM32A	PTPFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQ
Q6PEY2	T73	Sugiyama	TUBA3E	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2	T80	Sugiyama	TUBA3E	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q8NEM2	S42	Sugiyama	SHCBP1	GWAVEQELASLEKGLFQDEDsCsDCsYRDKPGssLQSFMPE
Q8NFI4	S181	Sugiyama	ST13P5 FAM10A5	LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96HE7	T148	Sugiyama	ERO1A ERO1L UNQ434/PRO865	IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3	Y449	Sugiyama	TUBA1C TUBA6	EKDyEEVGADsADGEDEGEEy____________________
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9Y3F4	S254	Sugiyama	STRAP MAWD UNRIP	EKEFLVAGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFS

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.175843e-08	7.379
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.750549e-05	4.757
Signaling by ALK in cancer	R-HSA-9700206	1.750549e-05	4.757
Chromatin organization	R-HSA-4839726	5.894550e-05	4.230
Transcriptional Regulation by E2F6	R-HSA-8953750	7.210108e-05	4.142
Chromatin modifying enzymes	R-HSA-3247509	8.371758e-05	4.077
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.612150e-04	3.793
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.665910e-04	3.574
Signaling by EGFR	R-HSA-177929	4.398663e-04	3.357
Diseases of mitotic cell cycle	R-HSA-9675126	9.744683e-04	3.011
mRNA Splicing - Major Pathway	R-HSA-72163	1.130853e-03	2.947
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.218042e-03	2.914
Cell Cycle	R-HSA-1640170	1.180026e-03	2.928
Estrogen-dependent gene expression	R-HSA-9018519	1.457085e-03	2.837
Cohesin Loading onto Chromatin	R-HSA-2470946	1.570258e-03	2.804
Cellular Senescence	R-HSA-2559583	1.771831e-03	2.752
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.874471e-03	2.727
Regulation of PTEN gene transcription	R-HSA-8943724	2.135061e-03	2.671
mRNA Splicing	R-HSA-72172	2.808516e-03	2.552
G0 and Early G1	R-HSA-1538133	2.856674e-03	2.544
Oncogenic MAPK signaling	R-HSA-6802957	2.915210e-03	2.535
Transcriptional Regulation by VENTX	R-HSA-8853884	2.735305e-03	2.563
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.514470e-03	2.600
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.856674e-03	2.544
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.758430e-03	2.559
NRAGE signals death through JNK	R-HSA-193648	2.693139e-03	2.570
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.206440e-03	2.494
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.472508e-03	2.459
Regulation of MECP2 expression and activity	R-HSA-9022692	3.503292e-03	2.456
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.503292e-03	2.456
XBP1(S) activates chaperone genes	R-HSA-381038	3.725779e-03	2.429
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.023552e-03	2.395
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.409917e-03	2.356
Signaling by ERBB2	R-HSA-1227986	4.862669e-03	2.313
Cell Cycle, Mitotic	R-HSA-69278	4.720069e-03	2.326
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.238124e-03	2.281
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.308438e-03	2.275
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.602017e-03	2.252
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.602017e-03	2.252
MITF-M-dependent gene expression	R-HSA-9856651	5.846688e-03	2.233
Metabolism of RNA	R-HSA-8953854	5.885925e-03	2.230
Signaling by Hippo	R-HSA-2028269	6.131525e-03	2.212
PKMTs methylate histone lysines	R-HSA-3214841	6.875619e-03	2.163
DNA Double-Strand Break Repair	R-HSA-5693532	7.475102e-03	2.126
ESR-mediated signaling	R-HSA-8939211	7.084374e-03	2.150
Apoptotic execution phase	R-HSA-75153	7.418188e-03	2.130
IRE1alpha activates chaperones	R-HSA-381070	7.358171e-03	2.133
ChREBP activates metabolic gene expression	R-HSA-163765	7.905545e-03	2.102
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.905545e-03	2.102
Ephrin signaling	R-HSA-3928664	7.889911e-03	2.103
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.889911e-03	2.103
Signaling by FGFR1 in disease	R-HSA-5655302	8.071570e-03	2.093
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.385794e-03	2.076
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.304751e-03	2.031
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.382353e-03	2.028
HATs acetylate histones	R-HSA-3214847	9.806433e-03	2.008
MTOR signalling	R-HSA-165159	9.425519e-03	2.026
p75 NTR receptor-mediated signalling	R-HSA-193704	9.806433e-03	2.008
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	9.942939e-03	2.002
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.055648e-02	1.976
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.082219e-02	1.966
Signal Transduction	R-HSA-162582	1.128242e-02	1.948
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.177093e-02	1.929
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.199663e-02	1.921
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.213682e-02	1.916
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.404502e-02	1.852
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.404502e-02	1.852
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.395852e-02	1.855
DNA Repair	R-HSA-73894	1.342437e-02	1.872
Death Receptor Signaling	R-HSA-73887	1.341287e-02	1.872
S Phase	R-HSA-69242	1.407869e-02	1.851
Inactivation of CDC42 and RAC1	R-HSA-428543	1.647946e-02	1.783
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.614421e-02	1.792
Intracellular signaling by second messengers	R-HSA-9006925	1.584213e-02	1.800
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.716059e-02	1.765
Unfolded Protein Response (UPR)	R-HSA-381119	1.801210e-02	1.744
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.885108e-02	1.725
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.918647e-02	1.717
Formation of editosomes by ADAR proteins	R-HSA-77042	2.503479e-02	1.601
Diseases of Telomere Maintenance	R-HSA-9673013	2.503479e-02	1.601
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.503479e-02	1.601
SDK interactions	R-HSA-373756	2.503479e-02	1.601
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.503479e-02	1.601
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.503479e-02	1.601
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.503479e-02	1.601
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.503479e-02	1.601
MET interacts with TNS proteins	R-HSA-8875513	2.370031e-02	1.625
MET activates RAP1 and RAC1	R-HSA-8875555	2.232316e-02	1.651
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.398758e-02	1.620
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.398758e-02	1.620
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.398758e-02	1.620
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.284011e-02	1.641
FGFR1 mutant receptor activation	R-HSA-1839124	2.284011e-02	1.641
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.383556e-02	1.623
mTORC1-mediated signalling	R-HSA-166208	2.276276e-02	1.643
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.381336e-02	1.623
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.066374e-02	1.685
Oxidative Stress Induced Senescence	R-HSA-2559580	2.308831e-02	1.637
Deubiquitination	R-HSA-5688426	2.062666e-02	1.686
Epigenetic regulation of gene expression	R-HSA-212165	2.509783e-02	1.600
PIP3 activates AKT signaling	R-HSA-1257604	2.595172e-02	1.586
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.650489e-02	1.577
Heme signaling	R-HSA-9707616	2.679150e-02	1.572
Ribosomal scanning and start codon recognition	R-HSA-72702	2.727994e-02	1.564
PTEN Regulation	R-HSA-6807070	2.909389e-02	1.536
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.934648e-02	1.532
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.006076e-02	1.522
DCC mediated attractive signaling	R-HSA-418885	3.006076e-02	1.522
Nuclear Envelope Breakdown	R-HSA-2980766	3.045511e-02	1.516
Nuclear signaling by ERBB4	R-HSA-1251985	3.113740e-02	1.507
Interactions of Rev with host cellular proteins	R-HSA-177243	3.113740e-02	1.507
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.751889e-02	1.426
Inhibition of TSC complex formation by PKB	R-HSA-165181	3.751889e-02	1.426
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.751889e-02	1.426
RUNX3 regulates WNT signaling	R-HSA-8951430	3.478757e-02	1.459
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.478757e-02	1.459
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.706145e-02	1.431
Negative regulation of MET activity	R-HSA-6807004	3.494929e-02	1.457
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.494929e-02	1.457
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.223295e-02	1.492
Formation of RNA Pol II elongation complex	R-HSA-112382	3.464381e-02	1.460
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.389180e-02	1.470
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.608820e-02	1.443
Prolonged ERK activation events	R-HSA-169893	3.706145e-02	1.431
Mitotic Anaphase	R-HSA-68882	3.598863e-02	1.444
Oncogene Induced Senescence	R-HSA-2559585	3.505974e-02	1.455
Mitotic Spindle Checkpoint	R-HSA-69618	3.358226e-02	1.474
Downregulation of ERBB2 signaling	R-HSA-8863795	3.411287e-02	1.467
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.478757e-02	1.459
ATP-dependent chromatin remodelers	R-HSA-9932444	3.784968e-02	1.422
SWI/SNF chromatin remodelers	R-HSA-9932451	3.784968e-02	1.422
Long-term potentiation	R-HSA-9620244	3.784968e-02	1.422
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.793035e-02	1.421
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.862547e-02	1.413
EGFR downregulation	R-HSA-182971	3.938723e-02	1.405
Translation initiation complex formation	R-HSA-72649	4.292084e-02	1.367
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.159026e-02	1.381
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.231813e-02	1.373
Signaling by WNT in cancer	R-HSA-4791275	4.518871e-02	1.345
DNA Double Strand Break Response	R-HSA-5693606	4.411494e-02	1.355
Transcriptional regulation by RUNX1	R-HSA-8878171	4.176079e-02	1.379
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.406570e-02	1.356
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.161149e-02	1.381
MITF-M-regulated melanocyte development	R-HSA-9730414	4.454947e-02	1.351
Downregulation of ERBB4 signaling	R-HSA-1253288	4.644362e-02	1.333
MET receptor recycling	R-HSA-8875656	4.644362e-02	1.333
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.644362e-02	1.333
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.727397e-02	1.325
Signaling by LTK	R-HSA-9842663	4.727397e-02	1.325
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.861177e-02	1.313
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.096523e-02	1.293
Nucleotide Excision Repair	R-HSA-5696398	5.268629e-02	1.278
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.397938e-02	1.268
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.461457e-02	1.263
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.461457e-02	1.263
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.461457e-02	1.263
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.533690e-02	1.257
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.615183e-02	1.251
ALK mutants bind TKIs	R-HSA-9700645	6.000953e-02	1.222
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.393659e-02	1.194
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.755436e-02	1.240
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.393659e-02	1.194
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.843596e-02	1.233
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.393659e-02	1.194
G alpha (12/13) signalling events	R-HSA-416482	6.458098e-02	1.190
M Phase	R-HSA-68886	6.488911e-02	1.188
RAF activation	R-HSA-5673000	6.590572e-02	1.181
Nuclear import of Rev protein	R-HSA-180746	6.590572e-02	1.181
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.630505e-02	1.178
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.477785e-02	1.126
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	7.477785e-02	1.126
Signaling by RNF43 mutants	R-HSA-5340588	7.477785e-02	1.126
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.045066e-02	1.152
Regulation of signaling by CBL	R-HSA-912631	7.490107e-02	1.126
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.490107e-02	1.126
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.909693e-02	1.161
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.909693e-02	1.161
Signaling downstream of RAS mutants	R-HSA-9649948	6.909693e-02	1.161
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.909693e-02	1.161
Signaling by RAS mutants	R-HSA-6802949	6.909693e-02	1.161
Cell Cycle Checkpoints	R-HSA-69620	6.718496e-02	1.173
Ub-specific processing proteases	R-HSA-5689880	7.067502e-02	1.151
Regulation of KIT signaling	R-HSA-1433559	7.045066e-02	1.152
Signaling by MET	R-HSA-6806834	7.536736e-02	1.123
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.557766e-02	1.122
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.557766e-02	1.122
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.563430e-02	1.067
mRNA Editing: A to I Conversion	R-HSA-75064	8.563430e-02	1.067
Regulation of TP53 Expression	R-HSA-6804754	8.563430e-02	1.067
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.563430e-02	1.067
Regulation of cortical dendrite branching	R-HSA-8985801	8.563430e-02	1.067
C6 deamination of adenosine	R-HSA-75102	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.563430e-02	1.067
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.563430e-02	1.067
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.563430e-02	1.067
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.400473e-02	1.076
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.400473e-02	1.076
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.513025e-02	1.070
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.513025e-02	1.070
Regulation of TP53 Degradation	R-HSA-6804757	8.257393e-02	1.083
Signaling by RAF1 mutants	R-HSA-9656223	7.952850e-02	1.099
Sema4D in semaphorin signaling	R-HSA-400685	8.679649e-02	1.061
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	8.563430e-02	1.067
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.984529e-02	1.098
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.686581e-02	1.061
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.686581e-02	1.061
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.686581e-02	1.061
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.686581e-02	1.061
Co-inhibition by CTLA4	R-HSA-389513	8.686581e-02	1.061
Separation of Sister Chromatids	R-HSA-2467813	8.808509e-02	1.055
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.141640e-01	0.942
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.141640e-01	0.942
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.141640e-01	0.942
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.141640e-01	0.942
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.141640e-01	0.942
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.153004e-01	0.667
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.153004e-01	0.667
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.153004e-01	0.667
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.153004e-01	0.667
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.153004e-01	0.667
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.153004e-01	0.667
Signaling by FGFR1 amplification mutants	R-HSA-1839120	1.238933e-01	0.907
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.238933e-01	0.907
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.238933e-01	0.907
MET activates PTPN11	R-HSA-8865999	1.238933e-01	0.907
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.653365e-01	0.782
Regulation of gap junction activity	R-HSA-191650	1.653365e-01	0.782
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.653365e-01	0.782
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.653365e-01	0.782
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.048953e-01	0.516
Signaling by TCF7L2 mutants	R-HSA-5339700	3.048953e-01	0.516
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.048953e-01	0.516
Defective SLC17A5 causes Salla disease (SD) and ISSD	R-HSA-5619035	3.048953e-01	0.516
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.048953e-01	0.516
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.048953e-01	0.516
PTEN Loss of Function in Cancer	R-HSA-5674404	3.048953e-01	0.516
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.048953e-01	0.516
Defective SLC26A2 causes chondrodysplasias	R-HSA-3560792	3.048953e-01	0.516
Defective TPMT causes TPMT deficiency	R-HSA-5578995	3.048953e-01	0.516
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.087392e-01	0.680
IRS activation	R-HSA-74713	2.087392e-01	0.680
G2 Phase	R-HSA-68911	2.087392e-01	0.680
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.087392e-01	0.680
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.505975e-01	0.822
Regulation of NPAS4 mRNA translation	R-HSA-9768778	1.505975e-01	0.822
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.115761e-01	0.952
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.115761e-01	0.952
Signaling by AMER1 mutants	R-HSA-4839748	1.115761e-01	0.952
Signaling by AXIN mutants	R-HSA-4839735	1.115761e-01	0.952
Phosphorylation of the APC/C	R-HSA-176412	9.882767e-02	1.005
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.320382e-01	0.879
Repression of WNT target genes	R-HSA-4641265	1.320382e-01	0.879
Pervasive developmental disorders	R-HSA-9005895	1.320382e-01	0.879
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.320382e-01	0.879
Disorders of Nervous System Development	R-HSA-9697154	1.320382e-01	0.879
ARMS-mediated activation	R-HSA-170984	1.798047e-01	0.745
WNT mediated activation of DVL	R-HSA-201688	1.798047e-01	0.745
Calcineurin activates NFAT	R-HSA-2025928	1.798047e-01	0.745
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.531144e-01	0.597
IkBA variant leads to EDA-ID	R-HSA-5603029	2.531144e-01	0.597
Signaling by MAPK mutants	R-HSA-9652817	2.531144e-01	0.597
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.842651e-01	0.415
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.842651e-01	0.415
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.842651e-01	0.415
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.842651e-01	0.415
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.842651e-01	0.415
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.842651e-01	0.415
Defective visual phototransduction due to STRA6 loss of function	R-HSA-9918449	3.842651e-01	0.415
Disorders of Developmental Biology	R-HSA-9675151	1.148684e-01	0.940
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.148684e-01	0.940
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.148684e-01	0.940
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.539066e-01	0.813
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.539066e-01	0.813
Receptor Mediated Mitophagy	R-HSA-8934903	2.103771e-01	0.677
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	2.103771e-01	0.677
PI3K events in ERBB2 signaling	R-HSA-1963642	1.320625e-01	0.879
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.770213e-01	0.752
Erythropoietin activates STAT5	R-HSA-9027283	2.976748e-01	0.526
GAB1 signalosome	R-HSA-180292	1.503337e-01	0.823
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.285433e-01	0.891
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	2.419701e-01	0.616
Signaling by APC mutants	R-HSA-4839744	2.419701e-01	0.616
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.419701e-01	0.616
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.419701e-01	0.616
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.419701e-01	0.616
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.012147e-01	0.696
Erythropoietin activates RAS	R-HSA-9027284	2.012147e-01	0.696
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.012147e-01	0.696
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.695965e-01	0.771
Regulation of PTEN mRNA translation	R-HSA-8943723	1.442464e-01	0.841
IPs transport between nucleus and cytosol	R-HSA-1855170	1.062507e-01	0.974
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.177716e-02	1.037
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.178004e-01	0.929
Deadenylation of mRNA	R-HSA-429947	1.607771e-01	0.794
Activation of RAC1	R-HSA-428540	2.742600e-01	0.562
Signaling by GSK3beta mutants	R-HSA-5339716	2.742600e-01	0.562
MECP2 regulates transcription factors	R-HSA-9022707	3.418002e-01	0.466
MET activates PI3K/AKT signaling	R-HSA-8851907	3.418002e-01	0.466
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.418002e-01	0.466
Regulation of PTEN localization	R-HSA-8948747	3.418002e-01	0.466
TRIF-mediated programmed cell death	R-HSA-2562578	3.418002e-01	0.466
Disinhibition of SNARE formation	R-HSA-114516	3.418002e-01	0.466
Recycling of eIF2:GDP	R-HSA-72731	3.418002e-01	0.466
SOS-mediated signalling	R-HSA-112412	3.418002e-01	0.466
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.418002e-01	0.466
PLC-gamma1 signalling	R-HSA-167021	4.545763e-01	0.342
Activated NTRK3 signals through PLCG1	R-HSA-9034793	4.545763e-01	0.342
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.545763e-01	0.342
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.545763e-01	0.342
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.545763e-01	0.342
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.545763e-01	0.342
Invadopodia formation	R-HSA-8941237	4.545763e-01	0.342
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.545763e-01	0.342
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.299906e-01	0.886
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.780791e-01	0.749
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.107199e-01	0.676
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.428020e-01	0.845
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.521532e-01	0.598
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.521532e-01	0.598
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.960911e-01	0.708
MET activates RAS signaling	R-HSA-8851805	3.069488e-01	0.513
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.069488e-01	0.513
SHC-related events triggered by IGF1R	R-HSA-2428933	3.069488e-01	0.513
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.069488e-01	0.513
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.069488e-01	0.513
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.069488e-01	0.513
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.069488e-01	0.513
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.069488e-01	0.513
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.069488e-01	0.513
G1/S-Specific Transcription	R-HSA-69205	1.562116e-01	0.806
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.323799e-01	0.634
mRNA 3'-end processing	R-HSA-72187	1.186368e-01	0.926
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.115150e-01	0.953
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.701927e-01	0.769
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.147480e-01	0.668
EPHA-mediated growth cone collapse	R-HSA-3928663	2.147480e-01	0.668
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.785594e-01	0.555
Activated NTRK2 signals through FYN	R-HSA-9032500	3.850091e-01	0.415
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.850091e-01	0.415
Signaling by MRAS-complex mutants	R-HSA-9660537	3.850091e-01	0.415
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.850091e-01	0.415
snRNP Assembly	R-HSA-191859	1.204575e-01	0.919
Metabolism of non-coding RNA	R-HSA-194441	1.204575e-01	0.919
MET promotes cell motility	R-HSA-8875878	1.847160e-01	0.733
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.339814e-01	0.631
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.397662e-01	0.469
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.397662e-01	0.469
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	1.144236e-01	0.941
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.604305e-01	0.795
Signaling by Erythropoietin	R-HSA-9006335	2.537207e-01	0.596
DARPP-32 events	R-HSA-180024	2.537207e-01	0.596
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.537207e-01	0.596
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.332529e-01	0.632
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.145269e-01	0.941
Amplification of signal from the kinetochores	R-HSA-141424	1.145269e-01	0.941
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.992489e-01	0.701
Downstream signaling of activated FGFR1	R-HSA-5654687	2.510970e-01	0.600
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.269360e-01	0.370
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.269360e-01	0.370
Gap junction degradation	R-HSA-190873	4.269360e-01	0.370
Activated NTRK2 signals through PLCG1	R-HSA-9026527	5.168622e-01	0.287
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.168622e-01	0.287
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.168622e-01	0.287
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.168622e-01	0.287
Signaling by LRP5 mutants	R-HSA-5339717	5.168622e-01	0.287
Signaling by MAP2K mutants	R-HSA-9652169	5.168622e-01	0.287
MAP2K and MAPK activation	R-HSA-5674135	2.475490e-01	0.606
RUNX2 regulates bone development	R-HSA-8941326	2.693336e-01	0.570
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.642546e-01	0.578
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.596043e-01	0.444
Signaling by ERBB4	R-HSA-1236394	2.022992e-01	0.694
Beta-catenin phosphorylation cascade	R-HSA-196299	4.048499e-01	0.393
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.003908e-01	0.998
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.003908e-01	0.998
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.867427e-01	0.413
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.673102e-01	0.330
2-LTR circle formation	R-HSA-164843	4.673102e-01	0.330
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.558241e-01	0.592
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.712116e-01	0.430
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.690422e-01	0.570
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.367198e-01	0.360
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.367198e-01	0.360
Cellular response to heat stress	R-HSA-3371556	2.132606e-01	0.671
Transcriptional regulation by RUNX3	R-HSA-8878159	2.439877e-01	0.613
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.137254e-01	0.383
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.137254e-01	0.383
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.137254e-01	0.383
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.234286e-01	0.490
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.787697e-01	0.422
Cap-dependent Translation Initiation	R-HSA-72737	2.371907e-01	0.625
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.099308e-01	0.509
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	2.207794e-01	0.656
PI-3K cascade:FGFR1	R-HSA-5654689	4.404386e-01	0.356
Notch-HLH transcription pathway	R-HSA-350054	4.404386e-01	0.356
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.059398e-01	0.296
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.059398e-01	0.296
Activated NTRK3 signals through RAS	R-HSA-9034864	5.059398e-01	0.296
NrCAM interactions	R-HSA-447038	5.720385e-01	0.243
NOSIP mediated eNOS trafficking	R-HSA-203754	5.720385e-01	0.243
NTRK2 activates RAC1	R-HSA-9032759	5.720385e-01	0.243
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	5.720385e-01	0.243
FLT3 signaling by CBL mutants	R-HSA-9706377	5.720385e-01	0.243
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.925652e-01	0.534
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.006589e-01	0.522
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.489737e-01	0.457
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.607961e-01	0.443
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.607961e-01	0.443
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.213112e-01	0.375
Activation of the pre-replicative complex	R-HSA-68962	4.419632e-01	0.355
Dual incision in TC-NER	R-HSA-6782135	4.075220e-01	0.390
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.983286e-01	0.302
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	4.983286e-01	0.302
AURKA Activation by TPX2	R-HSA-8854518	4.086633e-01	0.389
TRAF6 mediated NF-kB activation	R-HSA-933542	4.926593e-01	0.307
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.926593e-01	0.307
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.426969e-01	0.265
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.426969e-01	0.265
Signaling by activated point mutants of FGFR1	R-HSA-1839122	5.426969e-01	0.265
Activated NTRK2 signals through RAS	R-HSA-9026519	5.426969e-01	0.265
PI3K events in ERBB4 signaling	R-HSA-1250342	5.426969e-01	0.265
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.599519e-01	0.337
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.278280e-01	0.278
PKA activation	R-HSA-163615	5.278280e-01	0.278
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.566023e-01	0.340
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.808294e-01	0.318
Post-translational protein phosphorylation	R-HSA-8957275	4.504318e-01	0.346
Transcriptional regulation by RUNX2	R-HSA-8878166	4.462112e-01	0.350
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.047371e-01	0.297
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.997804e-01	0.301
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.427221e-01	0.265
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.775052e-01	0.238
Polymerase switching	R-HSA-69091	5.775052e-01	0.238
Leading Strand Synthesis	R-HSA-69109	5.775052e-01	0.238
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.209163e-01	0.207
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.209163e-01	0.207
Phosphorylation of Emi1	R-HSA-176417	6.209163e-01	0.207
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.209163e-01	0.207
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.209163e-01	0.207
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.209163e-01	0.207
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.194667e-01	0.284
Degradation of CDH1	R-HSA-9766229	5.369653e-01	0.270
COPI-mediated anterograde transport	R-HSA-6807878	5.340053e-01	0.272
Interaction between L1 and Ankyrins	R-HSA-445095	5.667789e-01	0.247
Centrosome maturation	R-HSA-380287	5.500481e-01	0.260
Regulation of PD-L1(CD274) translation	R-HSA-9909620	5.837839e-01	0.234
Telomere Extension By Telomerase	R-HSA-171319	5.901178e-01	0.229
Phase 0 - rapid depolarisation	R-HSA-5576892	5.901178e-01	0.229
CD28 dependent Vav1 pathway	R-HSA-389359	6.103306e-01	0.214
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.103306e-01	0.214
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.970030e-01	0.224
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.005661e-01	0.221
Lagging Strand Synthesis	R-HSA-69186	6.101249e-01	0.215
Meiotic synapsis	R-HSA-1221632	6.076264e-01	0.216
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.076264e-01	0.216
Degradation of DVL	R-HSA-4641258	6.162805e-01	0.210
Transcriptional Regulation by MECP2	R-HSA-8986944	1.638780e-01	0.785
Signaling by EGFR in Cancer	R-HSA-1643713	3.475204e-01	0.459
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.686861e-01	0.433
RNA Polymerase III Transcription	R-HSA-74158	4.213112e-01	0.375
Integrin signaling	R-HSA-354192	1.062507e-01	0.974
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.107199e-01	0.676
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.107199e-01	0.676
Eukaryotic Translation Initiation	R-HSA-72613	2.371907e-01	0.625
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.320625e-01	0.879
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.320625e-01	0.879
Processing of DNA double-strand break ends	R-HSA-5693607	2.880419e-01	0.541
Regulation of endogenous retroelements	R-HSA-9842860	3.974576e-01	0.401
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.312032e-01	0.636
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.419632e-01	0.355
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.503337e-01	0.823
Downstream signaling of activated FGFR3	R-HSA-5654708	4.185147e-01	0.378
Downstream signaling of activated FGFR4	R-HSA-5654716	4.419632e-01	0.355
Downstream signaling of activated FGFR2	R-HSA-5654696	5.756105e-01	0.240
Regulation of TP53 Activity	R-HSA-5633007	1.031298e-01	0.987
G1/S Transition	R-HSA-69206	3.419747e-01	0.466
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.419701e-01	0.616
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.003287e-01	0.999
Switching of origins to a post-replicative state	R-HSA-69052	1.221329e-01	0.913
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.983286e-01	0.302
VxPx cargo-targeting to cilium	R-HSA-5620916	5.837839e-01	0.234
Circadian clock	R-HSA-9909396	2.637923e-01	0.579
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.466474e-01	0.460
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.215101e-01	0.493
EPH-Ephrin signaling	R-HSA-2682334	2.614014e-01	0.583
Extension of Telomeres	R-HSA-180786	5.642174e-01	0.249
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.992489e-01	0.701
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.182169e-01	0.497
Generation of second messenger molecules	R-HSA-202433	2.152570e-01	0.667
IGF1R signaling cascade	R-HSA-2428924	1.709468e-01	0.767
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	4.367198e-01	0.360
TGFBR3 expression	R-HSA-9839394	1.780791e-01	0.749
DNA strand elongation	R-HSA-69190	3.152554e-01	0.501
Aggrephagy	R-HSA-9646399	5.047371e-01	0.297
Signal attenuation	R-HSA-74749	2.103771e-01	0.677
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.285433e-01	0.891
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.419632e-01	0.355
Integration of provirus	R-HSA-162592	5.426969e-01	0.265
Frs2-mediated activation	R-HSA-170968	1.539066e-01	0.813
Resolution of D-Loop Structures	R-HSA-5693537	1.178004e-01	0.929
Pexophagy	R-HSA-9664873	4.673102e-01	0.330
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.960911e-01	0.708
Insulin receptor signalling cascade	R-HSA-74751	5.082037e-01	0.294
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.062507e-01	0.974
Signaling by FGFR1	R-HSA-5654736	2.535496e-01	0.596
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.926593e-01	0.307
IRS-related events triggered by IGF1R	R-HSA-2428928	4.582551e-01	0.339
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.448293e-01	0.264
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.433952e-01	0.614
TCF dependent signaling in response to WNT	R-HSA-201681	1.538639e-01	0.813
Clathrin-mediated endocytosis	R-HSA-8856828	2.422425e-01	0.616
Transcriptional Regulation by TP53	R-HSA-3700989	1.290083e-01	0.889
Cyclin D associated events in G1	R-HSA-69231	2.985808e-01	0.525
G1 Phase	R-HSA-69236	2.985808e-01	0.525
Beta-catenin independent WNT signaling	R-HSA-3858494	4.890189e-01	0.311
Synthesis of DNA	R-HSA-69239	2.813940e-01	0.551
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.653365e-01	0.782
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.418002e-01	0.466
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.418002e-01	0.466
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.475204e-01	0.459
PI3K/AKT activation	R-HSA-198203	4.673102e-01	0.330
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.451363e-01	0.462
Cyclin E associated events during G1/S transition	R-HSA-69202	3.489737e-01	0.457
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.038743e-01	0.517
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.942444e-01	0.404
Transcriptional regulation by small RNAs	R-HSA-5578749	5.039325e-01	0.298
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.209163e-01	0.207
Terminal pathway of complement	R-HSA-166665	6.209163e-01	0.207
Signaling by FGFR	R-HSA-190236	5.605481e-01	0.251
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.809784e-01	0.419
Signaling by WNT	R-HSA-195721	1.658284e-01	0.780
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.821371e-01	0.740
Co-stimulation by CD28	R-HSA-389356	3.697215e-01	0.432
eNOS activation	R-HSA-203615	5.544463e-01	0.256
Cell-cell junction organization	R-HSA-421270	2.038436e-01	0.691
Adherens junctions interactions	R-HSA-418990	2.416901e-01	0.617
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.332529e-01	0.632
Signalling to ERKs	R-HSA-187687	1.428020e-01	0.845
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.332529e-01	0.632
Ca-dependent events	R-HSA-111996	2.642546e-01	0.578
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.712116e-01	0.430
Ca2+ pathway	R-HSA-4086398	3.942444e-01	0.404
IRS-mediated signalling	R-HSA-112399	5.303165e-01	0.275
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.103771e-01	0.677
EPHB-mediated forward signaling	R-HSA-3928662	4.423906e-01	0.354
Post NMDA receptor activation events	R-HSA-438064	4.965585e-01	0.304
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.741416e-01	0.562
Negative regulation of MAPK pathway	R-HSA-5675221	1.462876e-01	0.835
Mitotic Prometaphase	R-HSA-68877	1.263022e-01	0.899
Adipogenesis	R-HSA-9843745	5.147129e-01	0.288
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.653365e-01	0.782
Formation of axial mesoderm	R-HSA-9796292	3.397662e-01	0.469
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	5.168622e-01	0.287
CaM pathway	R-HSA-111997	2.693336e-01	0.570
PLC beta mediated events	R-HSA-112043	3.292854e-01	0.482
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.720385e-01	0.243
Trafficking of AMPA receptors	R-HSA-399719	4.651772e-01	0.332
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.853755e-01	0.414
NF-kB is activated and signals survival	R-HSA-209560	5.426969e-01	0.265
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.777936e-01	0.321
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.179962e-01	0.286
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	6.209163e-01	0.207
Cell junction organization	R-HSA-446728	1.817760e-01	0.740
Late Phase of HIV Life Cycle	R-HSA-162599	4.755293e-01	0.323
Calmodulin induced events	R-HSA-111933	2.693336e-01	0.570
Signaling by FGFR2	R-HSA-5654738	5.000778e-01	0.301
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.801705e-01	0.744
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.624039e-01	0.789
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.412710e-01	0.617
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.243681e-01	0.489
Signaling by FGFR4	R-HSA-5654743	2.812791e-01	0.551
Regulation of TNFR1 signaling	R-HSA-5357905	4.808294e-01	0.318
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.369653e-01	0.270
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.419952e-01	0.355
DAG and IP3 signaling	R-HSA-1489509	3.161177e-01	0.500
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.645346e-01	0.438
Cell-Cell communication	R-HSA-1500931	1.424159e-01	0.846
Gene expression (Transcription)	R-HSA-74160	1.052818e-01	0.978
RNA Polymerase II Transcription	R-HSA-73857	3.112882e-01	0.507
Signaling by FGFR3	R-HSA-5654741	3.161177e-01	0.500
Assembly of the pre-replicative complex	R-HSA-68867	5.931947e-01	0.227
Homology Directed Repair	R-HSA-5693538	1.869567e-01	0.728
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.682372e-01	0.571
Chaperone Mediated Autophagy	R-HSA-9613829	5.278280e-01	0.278
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.856746e-01	0.731
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.859553e-01	0.413
Signaling by VEGF	R-HSA-194138	2.605824e-01	0.584
TNF signaling	R-HSA-75893	3.736553e-01	0.428
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.087392e-01	0.680
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.087392e-01	0.680
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.531144e-01	0.597
Nuclear RNA decay	R-HSA-9930044	1.062507e-01	0.974
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.850091e-01	0.415
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.397662e-01	0.469
Signaling by FGFR4 in disease	R-HSA-5655291	3.724707e-01	0.429
mRNA Editing	R-HSA-75072	4.269360e-01	0.370
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.362998e-01	0.473
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.362998e-01	0.473
Killing mechanisms	R-HSA-9664420	4.367198e-01	0.360
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.367198e-01	0.360
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.046576e-01	0.516
Formation of the posterior neural plate	R-HSA-9832991	5.059398e-01	0.296
Activation of AKT2	R-HSA-165158	5.720385e-01	0.243
PI3K Cascade	R-HSA-109704	4.058745e-01	0.392
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.179962e-01	0.286
RAF/MAP kinase cascade	R-HSA-5673001	4.216310e-01	0.375
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.305695e-01	0.366
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.874843e-01	0.312
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.643274e-01	0.248
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.101249e-01	0.215
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.163538e-01	0.287
HIV Life Cycle	R-HSA-162587	2.995053e-01	0.524
Signaling by FGFR in disease	R-HSA-1226099	1.306419e-01	0.884
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.263156e-01	0.645
HDMs demethylate histones	R-HSA-3214842	1.780791e-01	0.749
MAPK1/MAPK3 signaling	R-HSA-5684996	4.769080e-01	0.322
Ovarian tumor domain proteases	R-HSA-5689896	1.701927e-01	0.769
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.901178e-01	0.229
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.126998e-01	0.213
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.563353e-01	0.255
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.723906e-01	0.242
Semaphorin interactions	R-HSA-373755	2.481666e-01	0.605
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.978984e-01	0.704
Acyl chain remodelling of PS	R-HSA-1482801	3.239207e-01	0.490
Selective autophagy	R-HSA-9663891	5.107682e-01	0.292
Membrane Trafficking	R-HSA-199991	2.312759e-01	0.636
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.047256e-01	0.980
Nephrin family interactions	R-HSA-373753	5.837839e-01	0.234
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.475204e-01	0.459
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.086633e-01	0.389
Signaling by Nuclear Receptors	R-HSA-9006931	2.224596e-01	0.653
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.653365e-01	0.782
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.269360e-01	0.370
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.168622e-01	0.287
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.168622e-01	0.287
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.213390e-01	0.916
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.673102e-01	0.330
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.720385e-01	0.243
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.426969e-01	0.265
G-protein beta:gamma signalling	R-HSA-397795	5.106408e-01	0.292
Signaling by ROBO receptors	R-HSA-376176	5.192416e-01	0.285
Deadenylation-dependent mRNA decay	R-HSA-429914	5.642174e-01	0.249
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.117922e-01	0.213
rRNA processing	R-HSA-72312	4.198612e-01	0.377
G-protein mediated events	R-HSA-112040	4.246700e-01	0.372
G2/M DNA damage checkpoint	R-HSA-69473	2.022992e-01	0.694
G2/M Checkpoints	R-HSA-69481	2.805737e-01	0.552
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.323799e-01	0.634
Activation of BH3-only proteins	R-HSA-114452	4.419632e-01	0.355
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.427221e-01	0.265
Axon guidance	R-HSA-422475	1.969898e-01	0.706
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.137179e-01	0.944
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.897581e-01	0.722
Rap1 signalling	R-HSA-392517	3.324354e-01	0.478
TBC/RABGAPs	R-HSA-8854214	2.812791e-01	0.551
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.101249e-01	0.215
Nervous system development	R-HSA-9675108	1.580740e-01	0.801
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.418002e-01	0.466
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.269360e-01	0.370
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.449821e-01	0.462
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.104860e-01	0.957
Spry regulation of FGF signaling	R-HSA-1295596	4.048499e-01	0.393
MAPK family signaling cascades	R-HSA-5683057	2.663972e-01	0.574
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	3.239207e-01	0.490
p75NTR signals via NF-kB	R-HSA-193639	4.048499e-01	0.393
Signaling by SCF-KIT	R-HSA-1433557	4.229827e-01	0.374
Polo-like kinase mediated events	R-HSA-156711	3.053717e-01	0.515
Mitotic Prophase	R-HSA-68875	2.775251e-01	0.557
Mismatch Repair	R-HSA-5358508	5.278280e-01	0.278
Neurexins and neuroligins	R-HSA-6794361	4.419952e-01	0.355
TCR signaling	R-HSA-202403	6.169802e-01	0.210
Programmed Cell Death	R-HSA-5357801	4.701984e-01	0.328
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.312032e-01	0.636
Inhibition of PKR	R-HSA-169131	2.153004e-01	0.667
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.238933e-01	0.907
MTF1 activates gene expression	R-HSA-5660489	1.653365e-01	0.782
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.653365e-01	0.782
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.048953e-01	0.516
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.048953e-01	0.516
Reelin signalling pathway	R-HSA-8866376	2.087392e-01	0.680
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.798047e-01	0.745
Unwinding of DNA	R-HSA-176974	1.798047e-01	0.745
Release of apoptotic factors from the mitochondria	R-HSA-111457	2.531144e-01	0.597
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.842651e-01	0.415
Interleukin-33 signaling	R-HSA-9014843	3.842651e-01	0.415
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.148684e-01	0.940
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.539066e-01	0.813
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.976748e-01	0.526
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.442464e-01	0.841
Class I peroxisomal membrane protein import	R-HSA-9603798	2.263156e-01	0.645
MET activates STAT3	R-HSA-8875791	4.545763e-01	0.342
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.228233e-01	0.911
RET signaling	R-HSA-8853659	1.562116e-01	0.806
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.850091e-01	0.415
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.332529e-01	0.632
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.269360e-01	0.370
RNA Polymerase II Transcription Termination	R-HSA-73856	2.214485e-01	0.655
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.048499e-01	0.393
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.481666e-01	0.605
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.020744e-01	0.694
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.673102e-01	0.330
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.367198e-01	0.360
Bicarbonate transporters	R-HSA-425381	5.059398e-01	0.296
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.720385e-01	0.243
Regulation of FZD by ubiquitination	R-HSA-4641263	4.983286e-01	0.302
Downstream signal transduction	R-HSA-186763	4.651772e-01	0.332
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.926593e-01	0.307
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.426969e-01	0.265
ERKs are inactivated	R-HSA-202670	5.426969e-01	0.265
Viral Messenger RNA Synthesis	R-HSA-168325	4.582551e-01	0.339
PKB-mediated events	R-HSA-109703	6.209163e-01	0.207
PDE3B signalling	R-HSA-165160	6.209163e-01	0.207
Cam-PDE 1 activation	R-HSA-111957	6.209163e-01	0.207
Noncanonical activation of NOTCH3	R-HSA-9017802	6.209163e-01	0.207
CDC6 association with the ORC:origin complex	R-HSA-68689	6.209163e-01	0.207
Smooth Muscle Contraction	R-HSA-445355	6.076264e-01	0.216
Signaling by NTRKs	R-HSA-166520	1.625327e-01	0.789
Early Phase of HIV Life Cycle	R-HSA-162594	3.867427e-01	0.413
Extra-nuclear estrogen signaling	R-HSA-9009391	5.992385e-01	0.222
Rab regulation of trafficking	R-HSA-9007101	4.220615e-01	0.375
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.907671e-01	0.536
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.428441e-01	0.615
Mitophagy	R-HSA-5205647	5.544463e-01	0.256
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.690422e-01	0.570
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.162805e-01	0.210
Signaling by PTK6	R-HSA-8848021	1.601064e-01	0.796
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.601064e-01	0.796
Common Pathway of Fibrin Clot Formation	R-HSA-140875	3.596043e-01	0.444
Activation of ATR in response to replication stress	R-HSA-176187	1.989509e-01	0.701
The NLRP3 inflammasome	R-HSA-844456	5.563353e-01	0.255
p75NTR recruits signalling complexes	R-HSA-209543	5.775052e-01	0.238
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.269360e-01	0.370
tRNA processing in the nucleus	R-HSA-6784531	3.449821e-01	0.462
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.092511e-01	0.510
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.389489e-01	0.358
Netrin-1 signaling	R-HSA-373752	1.060459e-01	0.975
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.997804e-01	0.301
Protein ubiquitination	R-HSA-8852135	1.394766e-01	0.855
NGF-stimulated transcription	R-HSA-9031628	5.185035e-01	0.285
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.179946e-01	0.209
FLT3 signaling in disease	R-HSA-9682385	4.213112e-01	0.375
Cellular responses to stress	R-HSA-2262752	2.138627e-01	0.670
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.531144e-01	0.597
Nef and signal transduction	R-HSA-164944	2.976748e-01	0.526
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.012147e-01	0.696
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.178004e-01	0.929
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.136110e-01	0.670
Interleukin-1 processing	R-HSA-448706	4.269360e-01	0.370
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.269360e-01	0.370
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.067710e-01	0.513
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.367198e-01	0.360
GPER1 signaling	R-HSA-9634597	5.185035e-01	0.285
Cellular responses to stimuli	R-HSA-8953897	2.923215e-01	0.534
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.642546e-01	0.578
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.372379e-01	0.863
NOD1/2 Signaling Pathway	R-HSA-168638	5.544463e-01	0.256
Apoptosis	R-HSA-109581	2.101075e-01	0.678
Formation of definitive endoderm	R-HSA-9823730	1.897581e-01	0.722
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.069488e-01	0.513
ISG15 antiviral mechanism	R-HSA-1169408	2.138010e-01	0.670
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.574937e-01	0.447
Host Interactions of HIV factors	R-HSA-162909	6.042394e-01	0.219
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.370718e-01	0.359
Regulation of NPAS4 gene expression	R-HSA-9768759	2.785594e-01	0.555
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.989509e-01	0.701
Signal transduction by L1	R-HSA-445144	3.596043e-01	0.444
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.427221e-01	0.265
Protein-protein interactions at synapses	R-HSA-6794362	5.727460e-01	0.242
Other interleukin signaling	R-HSA-449836	5.563353e-01	0.255
Interleukin-15 signaling	R-HSA-8983432	5.775052e-01	0.238
FLT3 Signaling	R-HSA-9607240	2.312032e-01	0.636
Signaling by TGFBR3	R-HSA-9839373	4.808294e-01	0.318
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.880419e-01	0.541
Inhibition of membrane repair	R-HSA-9635644	3.048953e-01	0.516
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.148684e-01	0.940
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.545763e-01	0.342
CASP5-mediated substrate cleavage	R-HSA-9960525	4.545763e-01	0.342
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.119092e-01	0.951
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.989509e-01	0.701
Maturation of nucleoprotein	R-HSA-9683610	3.397662e-01	0.469
Signaling by ALK	R-HSA-201556	1.997490e-01	0.700
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.053717e-01	0.515
NADE modulates death signalling	R-HSA-205025	5.168622e-01	0.287
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.367198e-01	0.360
Interleukin-36 pathway	R-HSA-9014826	5.720385e-01	0.243
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.426969e-01	0.265
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.777936e-01	0.321
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.106408e-01	0.292
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.775052e-01	0.238
Signalling to p38 via RIT and RIN	R-HSA-187706	6.209163e-01	0.207
MAPK6/MAPK4 signaling	R-HSA-5687128	5.727460e-01	0.242
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.229827e-01	0.374
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.169802e-01	0.210
Signal regulatory protein family interactions	R-HSA-391160	3.724707e-01	0.429
Cell-extracellular matrix interactions	R-HSA-446353	4.048499e-01	0.393
Inositol phosphate metabolism	R-HSA-1483249	1.819244e-01	0.740
MyD88-independent TLR4 cascade	R-HSA-166166	6.169802e-01	0.210
PI Metabolism	R-HSA-1483255	6.117922e-01	0.213
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.552346e-01	0.256
PECAM1 interactions	R-HSA-210990	9.266780e-02	1.033
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.976748e-01	0.526
Maturation of nucleoprotein	R-HSA-9694631	3.324354e-01	0.478
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.000628e-01	0.398
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.404386e-01	0.356
ERK/MAPK targets	R-HSA-198753	6.101249e-01	0.215
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.129277e-01	0.213
SARS-CoV-1-host interactions	R-HSA-9692914	5.678816e-01	0.246
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.130053e-01	0.290
Specification of the neural plate border	R-HSA-9834899	5.563353e-01	0.255
Diseases of DNA repair	R-HSA-9675135	3.338480e-01	0.476
STING mediated induction of host immune responses	R-HSA-1834941	3.324354e-01	0.478
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.616866e-01	0.336
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.842651e-01	0.415
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.418002e-01	0.466
CASP4-mediated substrate cleavage	R-HSA-9960519	4.545763e-01	0.342
Sodium/Proton exchangers	R-HSA-425986	3.850091e-01	0.415
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.312032e-01	0.636
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.168622e-01	0.287
Regulation of IFNG signaling	R-HSA-877312	5.775052e-01	0.238
Relaxin receptors	R-HSA-444821	6.209163e-01	0.207
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.103306e-01	0.214
Platelet Adhesion to exposed collagen	R-HSA-75892	6.103306e-01	0.214
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.126998e-01	0.213
Zygotic genome activation (ZGA)	R-HSA-9819196	6.101249e-01	0.215
Interleukin-7 signaling	R-HSA-1266695	3.239207e-01	0.490
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.148684e-01	0.940
Regulation of CDH11 gene transcription	R-HSA-9762293	1.798047e-01	0.745
Specification of primordial germ cells	R-HSA-9827857	2.785594e-01	0.555
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.147480e-01	0.668
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.059398e-01	0.296
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.426969e-01	0.265
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.209163e-01	0.207
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.712116e-01	0.430
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.005069e-01	0.522
Neurodegenerative Diseases	R-HSA-8863678	3.005069e-01	0.522
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.137254e-01	0.383
FOXO-mediated transcription	R-HSA-9614085	4.637664e-01	0.334
Josephin domain DUBs	R-HSA-5689877	4.673102e-01	0.330
Signaling by PDGFR in disease	R-HSA-9671555	4.137254e-01	0.383
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.720385e-01	0.243
Uptake and function of anthrax toxins	R-HSA-5210891	4.983286e-01	0.302
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.726973e-01	0.242
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.850091e-01	0.415
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.209163e-01	0.207
Nectin/Necl trans heterodimerization	R-HSA-420597	5.720385e-01	0.243
Signaling by Leptin	R-HSA-2586552	4.673102e-01	0.330
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.209163e-01	0.207
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.103306e-01	0.214
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	5.775052e-01	0.238
Formation of a pool of free 40S subunits	R-HSA-72689	6.319992e-01	0.199
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.326243e-01	0.199
DAP12 signaling	R-HSA-2424491	6.344941e-01	0.198
Interleukin-37 signaling	R-HSA-9008059	6.344941e-01	0.198
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.353250e-01	0.197
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.353250e-01	0.197
Macroautophagy	R-HSA-1632852	6.356158e-01	0.197
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.357301e-01	0.197
Opioid Signalling	R-HSA-111885	6.363277e-01	0.196
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.379641e-01	0.195
Gastrulation	R-HSA-9758941	6.398488e-01	0.194
CRMPs in Sema3A signaling	R-HSA-399956	6.411718e-01	0.193
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.411718e-01	0.193
NRIF signals cell death from the nucleus	R-HSA-205043	6.411718e-01	0.193
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.411718e-01	0.193
Non-canonical inflammasome activation	R-HSA-9686114	6.411718e-01	0.193
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.437583e-01	0.191
Stabilization of p53	R-HSA-69541	6.545607e-01	0.184
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.551708e-01	0.184
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.566451e-01	0.183
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.593649e-01	0.181
FGFR2 alternative splicing	R-HSA-6803529	6.593649e-01	0.181
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.593649e-01	0.181
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.593649e-01	0.181
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.593649e-01	0.181
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.593649e-01	0.181
RAF-independent MAPK1/3 activation	R-HSA-112409	6.593649e-01	0.181
Signaling by KIT in disease	R-HSA-9669938	6.593649e-01	0.181
Signaling by TGFB family members	R-HSA-9006936	6.631147e-01	0.178
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.642142e-01	0.178
Signaling by LTK in cancer	R-HSA-9842640	6.642142e-01	0.178
STAT5 Activation	R-HSA-9645135	6.642142e-01	0.178
Autointegration results in viral DNA circles	R-HSA-177539	6.642142e-01	0.178
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.642142e-01	0.178
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.642142e-01	0.178
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.642142e-01	0.178
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.642142e-01	0.178
Defective CYP11A1 causes AICSR	R-HSA-5579026	6.642142e-01	0.178
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.642142e-01	0.178
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.642142e-01	0.178
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.642142e-01	0.178
MET Receptor Activation	R-HSA-6806942	6.642142e-01	0.178
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.642142e-01	0.178
Lactose synthesis	R-HSA-5653890	6.642142e-01	0.178
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.642142e-01	0.178
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.642142e-01	0.178
Leukotriene receptors	R-HSA-391906	6.642142e-01	0.178
HDL clearance	R-HSA-8964011	6.642142e-01	0.178
CREB3 factors activate genes	R-HSA-8874211	6.642142e-01	0.178
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.642142e-01	0.178
Neurofascin interactions	R-HSA-447043	6.642142e-01	0.178
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	R-HSA-159763	6.642142e-01	0.178
HIV Infection	R-HSA-162906	6.647710e-01	0.177
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.688220e-01	0.175
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.688220e-01	0.175
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.688220e-01	0.175
Processive synthesis on the lagging strand	R-HSA-69183	6.700540e-01	0.174
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.700540e-01	0.174
SHC1 events in EGFR signaling	R-HSA-180336	6.700540e-01	0.174
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.700540e-01	0.174
Telomere C-strand synthesis initiation	R-HSA-174430	6.700540e-01	0.174
Lysosphingolipid and LPA receptors	R-HSA-419408	6.700540e-01	0.174
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.700540e-01	0.174
Protein methylation	R-HSA-8876725	6.700540e-01	0.174
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.700540e-01	0.174
Biotin transport and metabolism	R-HSA-196780	6.700540e-01	0.174
Formation of the anterior neural plate	R-HSA-9823739	6.700540e-01	0.174
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.700540e-01	0.174
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.700540e-01	0.174
DNA Damage Reversal	R-HSA-73942	6.700540e-01	0.174
Metal ion SLC transporters	R-HSA-425410	6.718633e-01	0.173
Regulation of CDH1 Function	R-HSA-9764561	6.721377e-01	0.173
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.727565e-01	0.172
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.743632e-01	0.171
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.756363e-01	0.170
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.822372e-01	0.166
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.822372e-01	0.166
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.822372e-01	0.166
Growth hormone receptor signaling	R-HSA-982772	6.822372e-01	0.166
Gene Silencing by RNA	R-HSA-211000	6.828942e-01	0.166
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.876289e-01	0.163
Signaling by NOTCH1	R-HSA-1980143	6.879639e-01	0.162
DNA Damage Bypass	R-HSA-73893	6.880305e-01	0.162
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.880305e-01	0.162
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.880305e-01	0.162
Mitotic G2-G2/M phases	R-HSA-453274	6.903158e-01	0.161
Eukaryotic Translation Elongation	R-HSA-156842	6.905196e-01	0.161
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.949596e-01	0.158
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.949596e-01	0.158
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.970221e-01	0.157
Regulation of BACH1 activity	R-HSA-9708530	6.970221e-01	0.157
Negative regulation of FLT3	R-HSA-9706369	6.970221e-01	0.157
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.014456e-01	0.154
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.025690e-01	0.153
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.025690e-01	0.153
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	7.025690e-01	0.153
Defective CHSY1 causes TPBS	R-HSA-3595177	7.025690e-01	0.153
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	7.025690e-01	0.153
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.025690e-01	0.153
PTK6 Expression	R-HSA-8849473	7.025690e-01	0.153
Phase 3 - rapid repolarisation	R-HSA-5576890	7.025690e-01	0.153
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	7.025690e-01	0.153
Reuptake of GABA	R-HSA-888593	7.025690e-01	0.153
VLDL clearance	R-HSA-8964046	7.025690e-01	0.153
Cation-coupled Chloride cotransporters	R-HSA-426117	7.025690e-01	0.153
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.025690e-01	0.153
Netrin mediated repulsion signals	R-HSA-418886	7.025690e-01	0.153
Removal of aminoterminal propeptides from gamma-carboxylated proteins	R-HSA-159782	7.025690e-01	0.153
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.039448e-01	0.152
Generic Transcription Pathway	R-HSA-212436	7.054266e-01	0.152
L1CAM interactions	R-HSA-373760	7.063476e-01	0.151
Autophagy	R-HSA-9612973	7.064039e-01	0.151
Golgi-to-ER retrograde transport	R-HSA-8856688	7.097273e-01	0.149
Striated Muscle Contraction	R-HSA-390522	7.134452e-01	0.147
PCP/CE pathway	R-HSA-4086400	7.136074e-01	0.147
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.159327e-01	0.145
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.159327e-01	0.145
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.159327e-01	0.145
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.159327e-01	0.145
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.159327e-01	0.145
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.159327e-01	0.145
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.159327e-01	0.145
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.221367e-01	0.141
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.221367e-01	0.141
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.221367e-01	0.141
Acetylcholine regulates insulin secretion	R-HSA-399997	7.221367e-01	0.141
tRNA modification in the mitochondrion	R-HSA-6787450	7.221367e-01	0.141
Response to metal ions	R-HSA-5660526	7.221367e-01	0.141
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.244995e-01	0.140
Tight junction interactions	R-HSA-420029	7.244995e-01	0.140
Chaperonin-mediated protein folding	R-HSA-390466	7.252177e-01	0.140
MAP kinase activation	R-HSA-450294	7.296171e-01	0.137
Dual Incision in GG-NER	R-HSA-5696400	7.310951e-01	0.136
NPAS4 regulates expression of target genes	R-HSA-9768919	7.310951e-01	0.136
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.310951e-01	0.136
Orc1 removal from chromatin	R-HSA-68949	7.333128e-01	0.135
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.333128e-01	0.135
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.357887e-01	0.133
Response of endothelial cells to shear stress	R-HSA-9860931	7.357887e-01	0.133
phospho-PLA2 pathway	R-HSA-111995	7.365448e-01	0.133
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.365448e-01	0.133
FGFR1b ligand binding and activation	R-HSA-190370	7.365448e-01	0.133
Formation of annular gap junctions	R-HSA-196025	7.365448e-01	0.133
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.365448e-01	0.133
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.365448e-01	0.133
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.365448e-01	0.133
Type I hemidesmosome assembly	R-HSA-446107	7.365448e-01	0.133
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.365448e-01	0.133
Regulation by c-FLIP	R-HSA-3371378	7.365448e-01	0.133
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.365448e-01	0.133
TGFBR3 PTM regulation	R-HSA-9839383	7.365448e-01	0.133
Dimerization of procaspase-8	R-HSA-69416	7.365448e-01	0.133
Adrenoceptors	R-HSA-390696	7.365448e-01	0.133
ROBO receptors bind AKAP5	R-HSA-9010642	7.365448e-01	0.133
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.366270e-01	0.133
Diseases of programmed cell death	R-HSA-9645723	7.366270e-01	0.133
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.378414e-01	0.132
SARS-CoV-2-host interactions	R-HSA-9705683	7.381784e-01	0.132
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.398199e-01	0.131
Regulation of mitotic cell cycle	R-HSA-453276	7.398199e-01	0.131
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.428396e-01	0.129
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.428396e-01	0.129
Myogenesis	R-HSA-525793	7.439207e-01	0.128
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.439207e-01	0.128
TRP channels	R-HSA-3295583	7.439207e-01	0.128
Metalloprotease DUBs	R-HSA-5689901	7.439207e-01	0.128
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.454691e-01	0.128
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.454691e-01	0.128
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.466326e-01	0.127
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.473242e-01	0.126
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.479162e-01	0.126
PERK regulates gene expression	R-HSA-381042	7.479162e-01	0.126
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	7.519548e-01	0.124
RMTs methylate histone arginines	R-HSA-3214858	7.539568e-01	0.123
Cellular responses to mechanical stimuli	R-HSA-9855142	7.554485e-01	0.122
G1/S DNA Damage Checkpoints	R-HSA-69615	7.555997e-01	0.122
DNA Replication	R-HSA-69306	7.565453e-01	0.121
Telomere Maintenance	R-HSA-157579	7.569851e-01	0.121
Base Excision Repair	R-HSA-73884	7.584811e-01	0.120
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.606461e-01	0.119
RNA Polymerase I Transcription Termination	R-HSA-73863	7.622336e-01	0.118
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.622336e-01	0.118
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.622336e-01	0.118
Signaling by FGFR3 in disease	R-HSA-5655332	7.622336e-01	0.118
Triglyceride biosynthesis	R-HSA-75109	7.622336e-01	0.118
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.639194e-01	0.117
MAPK1 (ERK2) activation	R-HSA-112411	7.666412e-01	0.115
CASP8 activity is inhibited	R-HSA-5218900	7.666412e-01	0.115
Enzymatic degradation of Dopamine by monoamine oxidase	R-HSA-379398	7.666412e-01	0.115
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.666412e-01	0.115
p75NTR regulates axonogenesis	R-HSA-193697	7.666412e-01	0.115
Regulation of signaling by NODAL	R-HSA-1433617	7.666412e-01	0.115
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.666412e-01	0.115
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.666412e-01	0.115
GP1b-IX-V activation signalling	R-HSA-430116	7.666412e-01	0.115
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.666412e-01	0.115
Regulated proteolysis of p75NTR	R-HSA-193692	7.666412e-01	0.115
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.666412e-01	0.115
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.666412e-01	0.115
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.666412e-01	0.115
Cellular response to mitochondrial stress	R-HSA-9840373	7.666412e-01	0.115
RNA Polymerase III Transcription Termination	R-HSA-73980	7.670988e-01	0.115
FGFR1 ligand binding and activation	R-HSA-190242	7.670988e-01	0.115
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.670988e-01	0.115
PKA activation in glucagon signalling	R-HSA-164378	7.670988e-01	0.115
Apoptotic factor-mediated response	R-HSA-111471	7.670988e-01	0.115
Cytoprotection by HMOX1	R-HSA-9707564	7.715109e-01	0.113
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.737295e-01	0.111
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.737295e-01	0.111
HDACs deacetylate histones	R-HSA-3214815	7.737295e-01	0.111
HIV elongation arrest and recovery	R-HSA-167287	7.794688e-01	0.108
Pausing and recovery of HIV elongation	R-HSA-167290	7.794688e-01	0.108
Pyroptosis	R-HSA-5620971	7.794688e-01	0.108
Inflammasomes	R-HSA-622312	7.794688e-01	0.108
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.794688e-01	0.108
ER to Golgi Anterograde Transport	R-HSA-199977	7.803359e-01	0.108
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.843260e-01	0.106
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.861324e-01	0.105
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.861324e-01	0.105
Glycolysis	R-HSA-70171	7.862826e-01	0.104
PI-3K cascade:FGFR3	R-HSA-5654710	7.871102e-01	0.104
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.871102e-01	0.104
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.871102e-01	0.104
Translesion Synthesis by POLH	R-HSA-110320	7.871102e-01	0.104
E2F mediated regulation of DNA replication	R-HSA-113510	7.871102e-01	0.104
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.878427e-01	0.104
Protein folding	R-HSA-391251	7.888451e-01	0.103
Meiosis	R-HSA-1500620	7.921708e-01	0.101
DNA Replication Pre-Initiation	R-HSA-69002	7.932268e-01	0.101
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.932268e-01	0.101
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.933010e-01	0.101
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.933010e-01	0.101
Binding and entry of HIV virion	R-HSA-173107	7.933010e-01	0.101
Apoptosis induced DNA fragmentation	R-HSA-140342	7.933010e-01	0.101
EGFR Transactivation by Gastrin	R-HSA-2179392	7.933010e-01	0.101
Enzymatic degradation of dopamine by COMT	R-HSA-379397	7.933010e-01	0.101
Regulation of CDH11 function	R-HSA-9762292	7.933010e-01	0.101
CASP4 inflammasome assembly	R-HSA-9948001	7.933010e-01	0.101
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.935327e-01	0.100
Termination of translesion DNA synthesis	R-HSA-5656169	7.956605e-01	0.099
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.956605e-01	0.099
Regulation of gene expression in beta cells	R-HSA-210745	7.956605e-01	0.099
Mitochondrial biogenesis	R-HSA-1592230	7.998874e-01	0.097
PI-3K cascade:FGFR4	R-HSA-5654720	8.055907e-01	0.094
Pregnenolone biosynthesis	R-HSA-196108	8.055907e-01	0.094
Protein hydroxylation	R-HSA-9629569	8.055907e-01	0.094
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.066140e-01	0.093
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.071799e-01	0.093
G2/M Transition	R-HSA-69275	8.082655e-01	0.092
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.093735e-01	0.092
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.108464e-01	0.091
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.108464e-01	0.091
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.125560e-01	0.090
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.159326e-01	0.088
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.159326e-01	0.088
RNA Polymerase I Transcription	R-HSA-73864	8.163649e-01	0.088
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.169166e-01	0.088
LGI-ADAM interactions	R-HSA-5682910	8.169166e-01	0.088
Ionotropic activity of kainate receptors	R-HSA-451306	8.169166e-01	0.088
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	8.169166e-01	0.088
RHOBTB3 ATPase cycle	R-HSA-9706019	8.169166e-01	0.088
Synthesis of PI	R-HSA-1483226	8.169166e-01	0.088
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.169166e-01	0.088
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.169166e-01	0.088
Suppression of apoptosis	R-HSA-9635465	8.169166e-01	0.088
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.169166e-01	0.088
Interleukin-2 signaling	R-HSA-9020558	8.169166e-01	0.088
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.200828e-01	0.086
Regulation of beta-cell development	R-HSA-186712	8.202299e-01	0.086
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.226288e-01	0.085
Signalling to RAS	R-HSA-167044	8.226288e-01	0.085
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	8.226288e-01	0.085
Cargo concentration in the ER	R-HSA-5694530	8.250661e-01	0.084
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.250661e-01	0.084
Evasion by RSV of host interferon responses	R-HSA-9833109	8.250661e-01	0.084
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.261781e-01	0.083
Peptide chain elongation	R-HSA-156902	8.292939e-01	0.081
Kinesins	R-HSA-983189	8.305907e-01	0.081
Chromosome Maintenance	R-HSA-73886	8.310078e-01	0.080
Interleukin-17 signaling	R-HSA-448424	8.322448e-01	0.080
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.322649e-01	0.080
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.331124e-01	0.079
PKR-mediated signaling	R-HSA-9833482	8.347270e-01	0.078
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.347270e-01	0.078
PPARA activates gene expression	R-HSA-1989781	8.369721e-01	0.077
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.369721e-01	0.077
DS-GAG biosynthesis	R-HSA-2022923	8.378352e-01	0.077
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.378352e-01	0.077
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.378352e-01	0.077
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	8.378352e-01	0.077
Sodium/Calcium exchangers	R-HSA-425561	8.378352e-01	0.077
Gamma-carboxylation of protein precursors	R-HSA-159740	8.378352e-01	0.077
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.381449e-01	0.077
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.381878e-01	0.077
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.381878e-01	0.077
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.383128e-01	0.077
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.383128e-01	0.077
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.383612e-01	0.077
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.383612e-01	0.077
NoRC negatively regulates rRNA expression	R-HSA-427413	8.414568e-01	0.075
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.437510e-01	0.074
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.437510e-01	0.074
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.481777e-01	0.072
NCAM signaling for neurite out-growth	R-HSA-375165	8.498733e-01	0.071
Signaling by PDGF	R-HSA-186797	8.498733e-01	0.071
Cardiogenesis	R-HSA-9733709	8.507738e-01	0.070
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	8.521483e-01	0.069
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.527297e-01	0.069
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.536090e-01	0.069
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.563648e-01	0.067
RUNX3 regulates p14-ARF	R-HSA-8951936	8.563648e-01	0.067
Maple Syrup Urine Disease	R-HSA-9865114	8.563648e-01	0.067
Scavenging by Class F Receptors	R-HSA-3000484	8.563648e-01	0.067
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.563648e-01	0.067
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.563648e-01	0.067
GRB2 events in EGFR signaling	R-HSA-179812	8.563648e-01	0.067
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.563648e-01	0.067
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.563648e-01	0.067
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.563648e-01	0.067
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.563648e-01	0.067
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	8.563648e-01	0.067
VLDLR internalisation and degradation	R-HSA-8866427	8.563648e-01	0.067
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.563648e-01	0.067
OAS antiviral response	R-HSA-8983711	8.563648e-01	0.067
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	R-HSA-159854	8.563648e-01	0.067
Regulation of PTEN stability and activity	R-HSA-8948751	8.605391e-01	0.065
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.613746e-01	0.065
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.616951e-01	0.065
Effects of PIP2 hydrolysis	R-HSA-114508	8.623469e-01	0.064
Miscellaneous transport and binding events	R-HSA-5223345	8.623469e-01	0.064
Interleukin receptor SHC signaling	R-HSA-912526	8.659642e-01	0.063
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.659642e-01	0.063
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.659642e-01	0.063
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.659642e-01	0.063
Mitochondrial mRNA modification	R-HSA-9937008	8.659642e-01	0.063
Glucose metabolism	R-HSA-70326	8.679562e-01	0.062
Signaling by Insulin receptor	R-HSA-74752	8.682304e-01	0.061
Interleukin-1 signaling	R-HSA-9020702	8.698662e-01	0.061
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.707441e-01	0.060
Vesicle-mediated transport	R-HSA-5653656	8.708634e-01	0.060
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.727781e-01	0.059
FGFR1c ligand binding and activation	R-HSA-190373	8.727781e-01	0.059
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.727781e-01	0.059
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.727781e-01	0.059
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.727781e-01	0.059
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.727781e-01	0.059
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.727781e-01	0.059
rRNA modification in the mitochondrion	R-HSA-6793080	8.727781e-01	0.059
Interleukin-6 signaling	R-HSA-1059683	8.727781e-01	0.059
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.731233e-01	0.059
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.731233e-01	0.059
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.731233e-01	0.059
Influenza Infection	R-HSA-168255	8.733067e-01	0.059
DAP12 interactions	R-HSA-2172127	8.742958e-01	0.058
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.753964e-01	0.058
Signaling by NOTCH3	R-HSA-9012852	8.780887e-01	0.056
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.780982e-01	0.056
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.780982e-01	0.056
Cilium Assembly	R-HSA-5617833	8.813628e-01	0.055
UCH proteinases	R-HSA-5689603	8.815894e-01	0.055
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.815894e-01	0.055
Fanconi Anemia Pathway	R-HSA-6783310	8.832625e-01	0.054
Asymmetric localization of PCP proteins	R-HSA-4608870	8.832625e-01	0.054
Removal of the Flap Intermediate	R-HSA-69166	8.873167e-01	0.052
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.873167e-01	0.052
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.873167e-01	0.052
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.873167e-01	0.052
cGMP effects	R-HSA-418457	8.873167e-01	0.052
Hydrolysis of LPC	R-HSA-1483115	8.873167e-01	0.052
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.873167e-01	0.052
Physiological factors	R-HSA-5578768	8.873167e-01	0.052
Acyl chain remodeling of CL	R-HSA-1482798	8.873167e-01	0.052
Zinc transporters	R-HSA-435354	8.873167e-01	0.052
Translation of Structural Proteins	R-HSA-9694635	8.885069e-01	0.051
Platelet activation, signaling and aggregation	R-HSA-76002	8.891125e-01	0.051
PI-3K cascade:FGFR2	R-HSA-5654695	8.892103e-01	0.051
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.892103e-01	0.051
Hyaluronan degradation	R-HSA-2160916	8.892103e-01	0.051
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.892103e-01	0.051
Condensation of Prophase Chromosomes	R-HSA-2299718	8.916669e-01	0.050
mRNA Splicing - Minor Pathway	R-HSA-72165	8.916669e-01	0.050
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.916669e-01	0.050
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.916669e-01	0.050
Lysosome Vesicle Biogenesis	R-HSA-432720	8.924556e-01	0.049
GPVI-mediated activation cascade	R-HSA-114604	8.924556e-01	0.049
Nuclear Receptor transcription pathway	R-HSA-383280	8.950816e-01	0.048
Signaling by Interleukins	R-HSA-449147	8.957367e-01	0.048
Transcription of the HIV genome	R-HSA-167172	8.971775e-01	0.047
Reproduction	R-HSA-1474165	8.977052e-01	0.047
MET activates PTK2 signaling	R-HSA-8874081	8.993756e-01	0.046
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.993756e-01	0.046
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.993756e-01	0.046
Suppression of phagosomal maturation	R-HSA-9637687	8.993756e-01	0.046
Recycling pathway of L1	R-HSA-437239	8.995360e-01	0.046
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.995360e-01	0.046
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.001946e-01	0.046
RNA Polymerase III Chain Elongation	R-HSA-73780	9.001946e-01	0.046
Translesion synthesis by REV1	R-HSA-110312	9.001946e-01	0.046
p38MAPK events	R-HSA-171007	9.001946e-01	0.046
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.001946e-01	0.046
Protein lipoylation	R-HSA-9857492	9.001946e-01	0.046
Transport and metabolism of PAPS	R-HSA-174362	9.001946e-01	0.046
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.001946e-01	0.046
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.001946e-01	0.046
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.009739e-01	0.045
Degradation of AXIN	R-HSA-4641257	9.010943e-01	0.045
Cleavage of the damaged purine	R-HSA-110331	9.010943e-01	0.045
Sensory processing of sound	R-HSA-9659379	9.013252e-01	0.045
Cellular response to starvation	R-HSA-9711097	9.027683e-01	0.044
HCMV Early Events	R-HSA-9609690	9.066626e-01	0.043
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.086652e-01	0.042
Packaging Of Telomere Ends	R-HSA-171306	9.086652e-01	0.042
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.086652e-01	0.042
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.086652e-01	0.042
Synthesis of PE	R-HSA-1483213	9.086652e-01	0.042
Depurination	R-HSA-73927	9.091017e-01	0.041
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.098152e-01	0.041
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.098152e-01	0.041
Translesion synthesis by POLI	R-HSA-5656121	9.116015e-01	0.040
Defective GALNT3 causes HFTC	R-HSA-5083625	9.116015e-01	0.040
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.116015e-01	0.040
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.116015e-01	0.040
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.116015e-01	0.040
Activation of SMO	R-HSA-5635838	9.116015e-01	0.040
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	9.116015e-01	0.040
Differentiation of T cells	R-HSA-9945266	9.116015e-01	0.040
Regulation of NF-kappa B signaling	R-HSA-9758274	9.116015e-01	0.040
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.137719e-01	0.039
Gap junction trafficking and regulation	R-HSA-157858	9.137742e-01	0.039
Developmental Cell Lineages	R-HSA-9734767	9.148074e-01	0.039
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.163502e-01	0.038
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.165162e-01	0.038
Plasma lipoprotein clearance	R-HSA-8964043	9.165162e-01	0.038
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	9.171466e-01	0.038
Formation of the Early Elongation Complex	R-HSA-113418	9.171466e-01	0.038
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.171466e-01	0.038
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.171466e-01	0.038
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.171466e-01	0.038
Pyrimidine salvage	R-HSA-73614	9.171466e-01	0.038
Interleukin-1 family signaling	R-HSA-446652	9.177207e-01	0.037
Organelle biogenesis and maintenance	R-HSA-1852241	9.189178e-01	0.037
Signaling by FGFR2 in disease	R-HSA-5655253	9.201950e-01	0.036
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.212419e-01	0.036
G beta:gamma signalling through CDC42	R-HSA-8964616	9.217052e-01	0.035
Translesion synthesis by POLK	R-HSA-5655862	9.217052e-01	0.035
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.217052e-01	0.035
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.217052e-01	0.035
Phase 2 - plateau phase	R-HSA-5576893	9.217052e-01	0.035
TRAF3-dependent IRF activation pathway	R-HSA-918233	9.217052e-01	0.035
Fibronectin matrix formation	R-HSA-1566977	9.217052e-01	0.035
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.217052e-01	0.035
Synthesis of PG	R-HSA-1483148	9.217052e-01	0.035
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.233751e-01	0.035
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	9.233751e-01	0.035
HIV Transcription Elongation	R-HSA-167169	9.233751e-01	0.035
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.233751e-01	0.035
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.233751e-01	0.035
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.233751e-01	0.035
Glycogen metabolism	R-HSA-8982491	9.233751e-01	0.035
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.233751e-01	0.035
Diseases of Immune System	R-HSA-5260271	9.233751e-01	0.035
rRNA processing in the mitochondrion	R-HSA-8868766	9.233751e-01	0.035
Platelet degranulation	R-HSA-114608	9.235321e-01	0.035
Late endosomal microautophagy	R-HSA-9615710	9.248831e-01	0.034
mRNA Capping	R-HSA-72086	9.248831e-01	0.034
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.248831e-01	0.034
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.248831e-01	0.034
DNA methylation	R-HSA-5334118	9.248831e-01	0.034
Platelet calcium homeostasis	R-HSA-418360	9.248831e-01	0.034
HSF1-dependent transactivation	R-HSA-3371571	9.261836e-01	0.033
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.297141e-01	0.032
Maturation of spike protein	R-HSA-9694548	9.297141e-01	0.032
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.306546e-01	0.031
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.306546e-01	0.031
Glycogen storage diseases	R-HSA-3229121	9.306546e-01	0.031
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.306546e-01	0.031
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.306546e-01	0.031
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.317642e-01	0.031
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.319341e-01	0.031
Neurotransmitter clearance	R-HSA-112311	9.319341e-01	0.031
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.319341e-01	0.031
SARS-CoV-1 Infection	R-HSA-9678108	9.334445e-01	0.030
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.355674e-01	0.029
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.355674e-01	0.029
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.355674e-01	0.029
HIV Transcription Initiation	R-HSA-167161	9.355674e-01	0.029
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.355674e-01	0.029
Intra-Golgi traffic	R-HSA-6811438	9.355674e-01	0.029
Translation of Structural Proteins	R-HSA-9683701	9.355674e-01	0.029
SLC transporter disorders	R-HSA-5619102	9.358070e-01	0.029
Amino acids regulate mTORC1	R-HSA-9639288	9.369602e-01	0.028
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.383552e-01	0.028
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.383552e-01	0.028
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.383552e-01	0.028
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.384175e-01	0.028
G beta:gamma signalling through PLC beta	R-HSA-418217	9.385815e-01	0.028
Nephron development	R-HSA-9831926	9.385815e-01	0.028
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.385815e-01	0.028
Presynaptic function of Kainate receptors	R-HSA-500657	9.385815e-01	0.028
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.385815e-01	0.028
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.385815e-01	0.028
Platelet sensitization by LDL	R-HSA-432142	9.385815e-01	0.028
Tie2 Signaling	R-HSA-210993	9.385815e-01	0.028
Interleukin-12 signaling	R-HSA-9020591	9.399760e-01	0.027
Cleavage of the damaged pyrimidine	R-HSA-110329	9.409675e-01	0.026
Depyrimidination	R-HSA-73928	9.409675e-01	0.026
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.417940e-01	0.026
Eukaryotic Translation Termination	R-HSA-72764	9.421607e-01	0.026
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.456028e-01	0.024
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.456028e-01	0.024
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.456028e-01	0.024
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.456028e-01	0.024
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.456028e-01	0.024
RNA Polymerase II Promoter Escape	R-HSA-73776	9.459455e-01	0.024
Response of Mtb to phagocytosis	R-HSA-9637690	9.459455e-01	0.024
G alpha (z) signalling events	R-HSA-418597	9.462873e-01	0.024
tRNA processing	R-HSA-72306	9.471021e-01	0.024
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.495114e-01	0.022
Regulation of necroptotic cell death	R-HSA-5675482	9.495114e-01	0.022
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.503601e-01	0.022
Ion homeostasis	R-HSA-5578775	9.504609e-01	0.022
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.505306e-01	0.022
Surfactant metabolism	R-HSA-5683826	9.505306e-01	0.022
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.509042e-01	0.022
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.509042e-01	0.022
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.509042e-01	0.022
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.518217e-01	0.021
Glycogen synthesis	R-HSA-3322077	9.518217e-01	0.021
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.518217e-01	0.021
Signaling by NODAL	R-HSA-1181150	9.518217e-01	0.021
Acyl chain remodelling of PI	R-HSA-1482922	9.518217e-01	0.021
Eicosanoid ligand-binding receptors	R-HSA-391903	9.518217e-01	0.021
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.520769e-01	0.021
Regulated Necrosis	R-HSA-5218859	9.521701e-01	0.021
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.521701e-01	0.021
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.543395e-01	0.020
Acyl chain remodelling of PC	R-HSA-1482788	9.543395e-01	0.020
Glucagon signaling in metabolic regulation	R-HSA-163359	9.543395e-01	0.020
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.547508e-01	0.020
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.547508e-01	0.020
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.547508e-01	0.020
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.573299e-01	0.019
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	9.573299e-01	0.019
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.573299e-01	0.019
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.573299e-01	0.019
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.573299e-01	0.019
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.573299e-01	0.019
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.573299e-01	0.019
Acyl chain remodelling of PG	R-HSA-1482925	9.573299e-01	0.019
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.573299e-01	0.019
Integration of energy metabolism	R-HSA-163685	9.578750e-01	0.019
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.586321e-01	0.018
Signaling by NOTCH2	R-HSA-1980145	9.587239e-01	0.018
Hyaluronan metabolism	R-HSA-2142845	9.587239e-01	0.018
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.587239e-01	0.018
Signal amplification	R-HSA-392518	9.587239e-01	0.018
SARS-CoV-2 Infection	R-HSA-9694516	9.600515e-01	0.018
Selenocysteine synthesis	R-HSA-2408557	9.606782e-01	0.017
Hedgehog 'on' state	R-HSA-5632684	9.619668e-01	0.017
CS-GAG biosynthesis	R-HSA-2022870	9.622087e-01	0.017
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.622087e-01	0.017
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.622087e-01	0.017
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.622087e-01	0.017
Molybdenum cofactor biosynthesis	R-HSA-947581	9.622087e-01	0.017
Serine metabolism	R-HSA-977347	9.622087e-01	0.017
Glutathione synthesis and recycling	R-HSA-174403	9.622087e-01	0.017
Assembly Of The HIV Virion	R-HSA-175474	9.622087e-01	0.017
Ribosome-associated quality control	R-HSA-9948299	9.623899e-01	0.017
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.627030e-01	0.017
Regulation of Apoptosis	R-HSA-169911	9.627030e-01	0.017
Acyl chain remodelling of PE	R-HSA-1482839	9.627030e-01	0.017
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.630856e-01	0.016
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.636747e-01	0.016
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.636747e-01	0.016
Regulation of T cell activation by CD28 family	R-HSA-388841	9.643618e-01	0.016
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.647987e-01	0.016
Viral mRNA Translation	R-HSA-192823	9.655458e-01	0.015
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.655599e-01	0.015
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.661157e-01	0.015
HSF1 activation	R-HSA-3371511	9.663122e-01	0.015
PRC2 methylates histones and DNA	R-HSA-212300	9.663122e-01	0.015
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.665300e-01	0.015
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.665300e-01	0.015
Cellular hexose transport	R-HSA-189200	9.665300e-01	0.015
Ethanol oxidation	R-HSA-71384	9.665300e-01	0.015
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.665300e-01	0.015
LDL clearance	R-HSA-8964038	9.665300e-01	0.015
Potential therapeutics for SARS	R-HSA-9679191	9.676305e-01	0.014
Cellular response to chemical stress	R-HSA-9711123	9.677429e-01	0.014
Toll-like Receptor Cascades	R-HSA-168898	9.695524e-01	0.013
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.695838e-01	0.013
Voltage gated Potassium channels	R-HSA-1296072	9.695838e-01	0.013
Metabolism of folate and pterines	R-HSA-196757	9.695838e-01	0.013
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.698616e-01	0.013
Activation of HOX genes during differentiation	R-HSA-5619507	9.698616e-01	0.013
C-type lectin receptors (CLRs)	R-HSA-5621481	9.700726e-01	0.013
Termination of O-glycan biosynthesis	R-HSA-977068	9.703573e-01	0.013
Free fatty acids regulate insulin secretion	R-HSA-400451	9.703573e-01	0.013
ABC transporters in lipid homeostasis	R-HSA-1369062	9.703573e-01	0.013
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.703573e-01	0.013
Carnitine shuttle	R-HSA-200425	9.703573e-01	0.013
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.710986e-01	0.013
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.721690e-01	0.012
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.725480e-01	0.012
tRNA processing in the mitochondrion	R-HSA-6785470	9.725480e-01	0.012
Elastic fibre formation	R-HSA-1566948	9.725480e-01	0.012
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.725480e-01	0.012
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.737472e-01	0.012
Complex III assembly	R-HSA-9865881	9.737472e-01	0.012
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.737472e-01	0.012
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.737472e-01	0.012
Mitochondrial RNA degradation	R-HSA-9836573	9.737472e-01	0.012
TNFs bind their physiological receptors	R-HSA-5669034	9.737472e-01	0.012
Interleukin-6 family signaling	R-HSA-6783589	9.737472e-01	0.012
Activation of NF-kappaB in B cells	R-HSA-1169091	9.737694e-01	0.012
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.737694e-01	0.012
Meiotic recombination	R-HSA-912446	9.737694e-01	0.012
The phototransduction cascade	R-HSA-2514856	9.737694e-01	0.012
Ion transport by P-type ATPases	R-HSA-936837	9.745303e-01	0.011
Interleukin-12 family signaling	R-HSA-447115	9.748238e-01	0.011
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.752323e-01	0.011
RAS processing	R-HSA-9648002	9.752323e-01	0.011
Developmental Biology	R-HSA-1266738	9.752740e-01	0.011
Uptake and actions of bacterial toxins	R-HSA-5339562	9.760859e-01	0.011
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.767496e-01	0.010
Retinoid cycle disease events	R-HSA-2453864	9.767496e-01	0.010
Diseases associated with visual transduction	R-HSA-2474795	9.767496e-01	0.010
Diseases of the neuronal system	R-HSA-9675143	9.767496e-01	0.010
Laminin interactions	R-HSA-3000157	9.767496e-01	0.010
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.767496e-01	0.010
Stimuli-sensing channels	R-HSA-2672351	9.770510e-01	0.010
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.776618e-01	0.010
Interleukin-2 family signaling	R-HSA-451927	9.776618e-01	0.010
Integrin cell surface interactions	R-HSA-216083	9.780845e-01	0.010
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.785326e-01	0.009
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.794087e-01	0.009
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.794087e-01	0.009
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.794087e-01	0.009
Urea cycle	R-HSA-70635	9.794087e-01	0.009
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.798598e-01	0.009
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.798598e-01	0.009
Hedgehog 'off' state	R-HSA-5610787	9.805285e-01	0.009
Signaling by NOTCH	R-HSA-157118	9.812987e-01	0.008
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.817639e-01	0.008
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.817639e-01	0.008
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.817639e-01	0.008
Insulin processing	R-HSA-264876	9.817639e-01	0.008
Maturation of hRSV A proteins	R-HSA-9828806	9.817639e-01	0.008
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.818474e-01	0.008
Degradation of CRY and PER proteins	R-HSA-9932298	9.818474e-01	0.008
Heme biosynthesis	R-HSA-189451	9.818474e-01	0.008
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.818474e-01	0.008
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.823831e-01	0.008
Leishmania phagocytosis	R-HSA-9664417	9.823831e-01	0.008
Parasite infection	R-HSA-9664407	9.823831e-01	0.008
Amyloid fiber formation	R-HSA-977225	9.828079e-01	0.008
Transport to the Golgi and subsequent modification	R-HSA-948021	9.829912e-01	0.007
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.836103e-01	0.007
Muscle contraction	R-HSA-397014	9.836103e-01	0.007
Cytosolic tRNA aminoacylation	R-HSA-379716	9.836440e-01	0.007
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.836440e-01	0.007
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.838175e-01	0.007
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.838498e-01	0.007
Iron assimilation using enterobactin	R-HSA-9638334	9.838498e-01	0.007
MHC class II antigen presentation	R-HSA-2132295	9.845996e-01	0.007
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.846285e-01	0.007
COPII-mediated vesicle transport	R-HSA-204005	9.848251e-01	0.007
Synthesis of PA	R-HSA-1483166	9.850289e-01	0.007
Dectin-2 family	R-HSA-5621480	9.850289e-01	0.007
Defective pyroptosis	R-HSA-9710421	9.852671e-01	0.006
Interferon Signaling	R-HSA-913531	9.855799e-01	0.006
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.856973e-01	0.006
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.860994e-01	0.006
RSV-host interactions	R-HSA-9833110	9.865404e-01	0.006
Gap junction trafficking	R-HSA-190828	9.867331e-01	0.006
Methylation	R-HSA-156581	9.867331e-01	0.006
Cytokine Signaling in Immune system	R-HSA-1280215	9.872025e-01	0.006
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.874041e-01	0.006
Peroxisomal protein import	R-HSA-9033241	9.876192e-01	0.005
Amino acid transport across the plasma membrane	R-HSA-352230	9.876192e-01	0.005
Triglyceride metabolism	R-HSA-8979227	9.876192e-01	0.005
Nucleosome assembly	R-HSA-774815	9.880566e-01	0.005
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.880566e-01	0.005
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.880566e-01	0.005
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.880566e-01	0.005
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.880566e-01	0.005
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.880566e-01	0.005
tRNA Aminoacylation	R-HSA-379724	9.887470e-01	0.005
Budding and maturation of HIV virion	R-HSA-162588	9.887826e-01	0.005
Molecules associated with elastic fibres	R-HSA-2129379	9.887826e-01	0.005
HCMV Infection	R-HSA-9609646	9.887914e-01	0.005
Regulation of pyruvate metabolism	R-HSA-9861718	9.892511e-01	0.005
Signaling by NOTCH4	R-HSA-9013694	9.893394e-01	0.005
Co-inhibition by PD-1	R-HSA-389948	9.894314e-01	0.005
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.894708e-01	0.005
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.896093e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.897756e-01	0.004
Neddylation	R-HSA-8951664	9.899850e-01	0.004
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.900660e-01	0.004
Interferon gamma signaling	R-HSA-877300	9.901247e-01	0.004
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.902490e-01	0.004
Synthesis of PC	R-HSA-1483191	9.903286e-01	0.004
Regulation of insulin secretion	R-HSA-422356	9.908313e-01	0.004
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.911294e-01	0.004
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.912026e-01	0.004
Recycling of bile acids and salts	R-HSA-159418	9.912026e-01	0.004
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.912026e-01	0.004
Intraflagellar transport	R-HSA-5620924	9.913003e-01	0.004
Gluconeogenesis	R-HSA-70263	9.913003e-01	0.004
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.921764e-01	0.003
Chemokine receptors bind chemokines	R-HSA-380108	9.921764e-01	0.003
CS/DS degradation	R-HSA-2024101	9.922092e-01	0.003
Vpu mediated degradation of CD4	R-HSA-180534	9.922092e-01	0.003
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.922092e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.925335e-01	0.003
Downstream TCR signaling	R-HSA-202424	9.925335e-01	0.003
Cholesterol biosynthesis	R-HSA-191273	9.925534e-01	0.003
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.928312e-01	0.003
SARS-CoV Infections	R-HSA-9679506	9.929355e-01	0.003
Regulation of RAS by GAPs	R-HSA-5658442	9.929660e-01	0.003
Cellular response to hypoxia	R-HSA-1234174	9.930542e-01	0.003
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.931008e-01	0.003
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.931008e-01	0.003
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.931008e-01	0.003
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.931008e-01	0.003
RA biosynthesis pathway	R-HSA-5365859	9.931008e-01	0.003
Calnexin/calreticulin cycle	R-HSA-901042	9.931008e-01	0.003
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.931008e-01	0.003
Branched-chain amino acid catabolism	R-HSA-70895	9.936773e-01	0.003
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.938903e-01	0.003
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.938903e-01	0.003
SLC-mediated transport of amino acids	R-HSA-9958863	9.942857e-01	0.002
RNA Polymerase I Promoter Escape	R-HSA-73772	9.943181e-01	0.002
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.943181e-01	0.002
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.945895e-01	0.002
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.945895e-01	0.002
FGFR2 mutant receptor activation	R-HSA-1839126	9.945895e-01	0.002
Phospholipid metabolism	R-HSA-1483257	9.946662e-01	0.002
Mitochondrial protein degradation	R-HSA-9837999	9.951426e-01	0.002
TRAF6 mediated IRF7 activation	R-HSA-933541	9.952088e-01	0.002
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.952088e-01	0.002
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.952088e-01	0.002
NCAM1 interactions	R-HSA-419037	9.952088e-01	0.002
Collagen chain trimerization	R-HSA-8948216	9.952088e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.957572e-01	0.002
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.959190e-01	0.002
Metabolism of cofactors	R-HSA-8978934	9.961455e-01	0.002
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.962428e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.962428e-01	0.002
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.962428e-01	0.002
Leishmania infection	R-HSA-9658195	9.963344e-01	0.002
Parasitic Infection Pathways	R-HSA-9824443	9.963344e-01	0.002
Adaptive Immune System	R-HSA-1280218	9.966467e-01	0.001
Attenuation phase	R-HSA-3371568	9.966729e-01	0.001
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.966729e-01	0.001
Cardiac conduction	R-HSA-5576891	9.968542e-01	0.001
Protein localization	R-HSA-9609507	9.968666e-01	0.001
Hh mutants are degraded by ERAD	R-HSA-5362768	9.970538e-01	0.001
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.970538e-01	0.001
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.970538e-01	0.001
Aflatoxin activation and detoxification	R-HSA-5423646	9.970538e-01	0.001
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.973263e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.973401e-01	0.001
Scavenging by Class A Receptors	R-HSA-3000480	9.973911e-01	0.001
HCMV Late Events	R-HSA-9610379	9.976642e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.976898e-01	0.001
Endogenous sterols	R-HSA-211976	9.978481e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.978481e-01	0.001
Aquaporin-mediated transport	R-HSA-445717	9.978481e-01	0.001
Transmission across Chemical Synapses	R-HSA-112315	9.979451e-01	0.001
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.979543e-01	0.001
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.980700e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.981244e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.981466e-01	0.001
Proteasome assembly	R-HSA-9907900	9.981885e-01	0.001
Amine ligand-binding receptors	R-HSA-375280	9.981885e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.982646e-01	0.001
Signaling by Hedgehog	R-HSA-5358351	9.983261e-01	0.001
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.983960e-01	0.001
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.983960e-01	0.001
Somitogenesis	R-HSA-9824272	9.983960e-01	0.001
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.983960e-01	0.001
Platelet homeostasis	R-HSA-418346	9.985983e-01	0.001
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.986844e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.987423e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.988450e-01	0.001
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.988827e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.988827e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.989335e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.989528e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.989528e-01	0.000
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.989693e-01	0.000
Translation	R-HSA-72766	9.989832e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.991269e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.991363e-01	0.000
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.991497e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.991966e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.992159e-01	0.000
Complex IV assembly	R-HSA-9864848	9.992269e-01	0.000
Hedgehog ligand biogenesis	R-HSA-5358346	9.992269e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992325e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.992804e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.992804e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.992804e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.992883e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.993074e-01	0.000
Purine catabolism	R-HSA-74259	9.993556e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.993939e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.994363e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.994485e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.994684e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.994747e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.994901e-01	0.000
Post-translational protein modification	R-HSA-597592	9.995074e-01	0.000
Ion channel transport	R-HSA-983712	9.995176e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.995248e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.995248e-01	0.000
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.995793e-01	0.000
Neuronal System	R-HSA-112316	9.996121e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.996273e-01	0.000
FCGR activation	R-HSA-2029481	9.996641e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.996686e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.996852e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.997035e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.997035e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.997051e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.997080e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.997328e-01	0.000
Glutathione conjugation	R-HSA-156590	9.997414e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.997414e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.997414e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.997580e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.997627e-01	0.000
Collagen degradation	R-HSA-1442490	9.997711e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.997813e-01	0.000
Mitochondrial protein import	R-HSA-1268020	9.997973e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.998206e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.998303e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998385e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.998411e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.998789e-01	0.000
Kidney development	R-HSA-9830369	9.998897e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.998897e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999024e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.999024e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999226e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999254e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999254e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999323e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999323e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999469e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999530e-01	0.000
Collagen formation	R-HSA-1474290	9.999560e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999584e-01	0.000
Iron uptake and transport	R-HSA-917937	9.999584e-01	0.000
Potassium Channels	R-HSA-1296071	9.999687e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.999711e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999711e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999765e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999826e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999827e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999842e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999888e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999915e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999916e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999949e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999970e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999972e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.999972e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999973e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999975e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999981e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999985e-01	0.000
Hemostasis	R-HSA-109582	9.999988e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999992e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999994e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999995e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999997e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999997e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999998e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	4.440892e-16	15.353
Cellular responses to stimuli	R-HSA-8953897	1.110223e-15	14.955
M Phase	R-HSA-68886	1.887379e-15	14.724
Axon guidance	R-HSA-422475	2.331468e-15	14.632
Nervous system development	R-HSA-9675108	7.771561e-15	14.109
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	6.676881e-13	12.175
Cellular response to heat stress	R-HSA-3371556	1.998735e-12	11.699
Cell-Cell communication	R-HSA-1500931	3.141931e-12	11.503
Cell Cycle Checkpoints	R-HSA-69620	3.504197e-12	11.455
Metabolism of RNA	R-HSA-8953854	1.566036e-11	10.805
Mitotic Anaphase	R-HSA-68882	3.794098e-11	10.421
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.544687e-11	10.342
G2/M Checkpoints	R-HSA-69481	4.321643e-11	10.364
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.683398e-11	10.329
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.270173e-11	10.082
Separation of Sister Chromatids	R-HSA-2467813	1.351323e-10	9.869
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.943165e-10	9.711
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.766666e-10	9.010
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.015393e-09	8.993
Apoptosis	R-HSA-109581	1.094751e-09	8.961
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.381671e-09	8.860
Cell junction organization	R-HSA-446728	2.590293e-09	8.587
HSF1-dependent transactivation	R-HSA-3371571	5.139113e-09	8.289
Mitotic Prometaphase	R-HSA-68877	7.334865e-09	8.135
Apoptotic execution phase	R-HSA-75153	7.536167e-09	8.123
G2/M Transition	R-HSA-69275	8.537921e-09	8.069
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.725212e-09	8.012
Cytokine Signaling in Immune system	R-HSA-1280215	1.074749e-08	7.969
Mitotic G2-G2/M phases	R-HSA-453274	1.259263e-08	7.900
Signaling by VEGF	R-HSA-194138	1.606927e-08	7.794
Programmed Cell Death	R-HSA-5357801	1.916386e-08	7.718
Cellular Senescence	R-HSA-2559583	2.571486e-08	7.590
PKR-mediated signaling	R-HSA-9833482	5.174870e-08	7.286
G2/M DNA damage checkpoint	R-HSA-69473	6.435018e-08	7.191
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.011675e-07	6.995
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.132203e-07	6.946
Signaling by ALK in cancer	R-HSA-9700206	1.132203e-07	6.946
Interleukin-12 signaling	R-HSA-9020591	1.176346e-07	6.929
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.526407e-07	6.816
Oxidative Stress Induced Senescence	R-HSA-2559580	1.532767e-07	6.815
mRNA Splicing - Major Pathway	R-HSA-72163	1.603417e-07	6.795
Deubiquitination	R-HSA-5688426	1.711929e-07	6.767
Cell-cell junction organization	R-HSA-421270	1.758306e-07	6.755
Adherens junctions interactions	R-HSA-418990	1.782773e-07	6.749
Signaling by ROBO receptors	R-HSA-376176	1.875585e-07	6.727
Aggrephagy	R-HSA-9646399	1.948676e-07	6.710
Membrane Trafficking	R-HSA-199991	2.037435e-07	6.691
Intracellular signaling by second messengers	R-HSA-9006925	2.148311e-07	6.668
Eukaryotic Translation Initiation	R-HSA-72613	2.643290e-07	6.578
Cap-dependent Translation Initiation	R-HSA-72737	2.643290e-07	6.578
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.415376e-07	6.467
Signal Transduction	R-HSA-162582	3.821341e-07	6.418
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.296840e-07	6.367
DNA Double Strand Break Response	R-HSA-5693606	4.525811e-07	6.344
mRNA Splicing	R-HSA-72172	5.098560e-07	6.293
Mitotic Prophase	R-HSA-68875	6.309152e-07	6.200
ISG15 antiviral mechanism	R-HSA-1169408	6.310362e-07	6.200
Attenuation phase	R-HSA-3371568	6.480934e-07	6.188
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.891736e-07	6.103
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.933217e-07	6.101
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.108349e-06	5.955
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.108349e-06	5.955
Interleukin-12 family signaling	R-HSA-447115	1.181726e-06	5.927
Recycling pathway of L1	R-HSA-437239	1.214026e-06	5.916
L1CAM interactions	R-HSA-373760	1.345754e-06	5.871
Translation initiation complex formation	R-HSA-72649	1.420996e-06	5.847
HSF1 activation	R-HSA-3371511	1.470841e-06	5.832
Selective autophagy	R-HSA-9663891	1.511996e-06	5.820
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.702135e-06	5.769
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.744790e-06	5.758
DNA Double-Strand Break Repair	R-HSA-5693532	1.916247e-06	5.718
HDACs deacetylate histones	R-HSA-3214815	1.943495e-06	5.711
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.077628e-06	5.682
EPH-Ephrin signaling	R-HSA-2682334	2.086844e-06	5.681
PIP3 activates AKT signaling	R-HSA-1257604	2.206784e-06	5.656
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.222728e-06	5.653
PTEN Regulation	R-HSA-6807070	2.266443e-06	5.645
Assembly of the pre-replicative complex	R-HSA-68867	2.631599e-06	5.580
Ribosomal scanning and start codon recognition	R-HSA-72702	2.638236e-06	5.579
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.292517e-06	5.482
Regulation of CDH1 Function	R-HSA-9764561	3.555373e-06	5.449
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.669907e-06	5.435
Signaling by Interleukins	R-HSA-449147	3.927767e-06	5.406
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.223325e-06	5.374
Ub-specific processing proteases	R-HSA-5689880	4.234280e-06	5.373
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.515282e-06	5.345
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.761550e-06	5.322
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.993977e-06	5.302
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	5.025236e-06	5.299
Transport of connexons to the plasma membrane	R-HSA-190872	5.698210e-06	5.244
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.914281e-06	5.228
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.291872e-06	5.201
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.411613e-06	5.193
Chromatin modifying enzymes	R-HSA-3247509	6.528467e-06	5.185
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.152105e-06	5.146
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.467315e-06	5.072
Chromatin organization	R-HSA-4839726	8.504447e-06	5.070
Regulation of signaling by CBL	R-HSA-912631	9.568817e-06	5.019
Nuclear Envelope Breakdown	R-HSA-2980766	9.533033e-06	5.021
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	9.323185e-06	5.030
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.662581e-06	5.015
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.058940e-05	4.975
DNA Replication Pre-Initiation	R-HSA-69002	1.068495e-05	4.971
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.163435e-05	4.934
SARS-CoV-1-host interactions	R-HSA-9692914	1.271838e-05	4.896
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.478267e-05	4.830
Interferon Signaling	R-HSA-913531	1.528811e-05	4.816
Post NMDA receptor activation events	R-HSA-438064	1.555113e-05	4.808
Striated Muscle Contraction	R-HSA-390522	1.576790e-05	4.802
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.794720e-05	4.746
Signaling by ERBB2	R-HSA-1227986	2.142037e-05	4.669
Regulation of PTEN gene transcription	R-HSA-8943724	2.142037e-05	4.669
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.142037e-05	4.669
RNA Polymerase I Transcription	R-HSA-73864	2.042614e-05	4.690
Estrogen-dependent gene expression	R-HSA-9018519	2.214616e-05	4.655
Chaperone Mediated Autophagy	R-HSA-9613829	2.297929e-05	4.639
Autophagy	R-HSA-9612973	2.352710e-05	4.628
Macroautophagy	R-HSA-1632852	2.565039e-05	4.591
Host Interactions of HIV factors	R-HSA-162909	2.728684e-05	4.564
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.019814e-05	4.520
COPI-mediated anterograde transport	R-HSA-6807878	3.110377e-05	4.507
Ribosome-associated quality control	R-HSA-9948299	3.066874e-05	4.513
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.196450e-05	4.495
MITF-M-dependent gene expression	R-HSA-9856651	3.359838e-05	4.474
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.417910e-05	4.466
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.561194e-05	4.448
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.566911e-05	4.448
Transcriptional regulation by RUNX1	R-HSA-8878171	3.808576e-05	4.419
Processing of DNA double-strand break ends	R-HSA-5693607	3.972458e-05	4.401
Homology Directed Repair	R-HSA-5693538	3.900026e-05	4.409
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.188030e-05	4.378
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.544842e-05	4.342
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.814186e-05	4.317
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.814467e-05	4.317
ESR-mediated signaling	R-HSA-8939211	4.966715e-05	4.304
Eukaryotic Translation Elongation	R-HSA-156842	5.372057e-05	4.270
Formation of a pool of free 40S subunits	R-HSA-72689	5.466597e-05	4.262
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.810114e-05	4.236
Transcriptional regulation by small RNAs	R-HSA-5578749	6.582744e-05	4.182
EPHB-mediated forward signaling	R-HSA-3928662	8.537755e-05	4.069
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	8.193369e-05	4.087
Signaling by PTK6	R-HSA-8848021	1.083947e-04	3.965
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.083947e-04	3.965
NoRC negatively regulates rRNA expression	R-HSA-427413	1.204716e-04	3.919
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.277617e-04	3.894
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.402792e-04	3.853
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.463905e-04	3.834
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.488437e-04	3.827
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.557298e-04	3.808
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.694545e-04	3.771
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.905362e-04	3.720
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.928612e-04	3.715
MITF-M-regulated melanocyte development	R-HSA-9730414	1.906782e-04	3.720
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.960580e-04	3.708
mTORC1-mediated signalling	R-HSA-166208	1.960984e-04	3.708
Influenza Infection	R-HSA-168255	1.994015e-04	3.700
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.161178e-04	3.665
Cyclin E associated events during G1/S transition	R-HSA-69202	2.179622e-04	3.662
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.330757e-04	3.633
Semaphorin interactions	R-HSA-373755	2.496787e-04	3.603
Regulation of Apoptosis	R-HSA-169911	2.559210e-04	3.592
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.636566e-04	3.579
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.636566e-04	3.579
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.887548e-04	3.539
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.887548e-04	3.539
Nucleosome assembly	R-HSA-774815	2.845153e-04	3.546
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.845153e-04	3.546
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.813684e-04	3.551
S Phase	R-HSA-69242	2.856374e-04	3.544
DNA Repair	R-HSA-73894	2.931546e-04	3.533
Stabilization of p53	R-HSA-69541	2.955428e-04	3.529
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.955428e-04	3.529
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.995473e-04	3.524
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.995473e-04	3.524
Ephrin signaling	R-HSA-3928664	3.089561e-04	3.510
Gap junction trafficking and regulation	R-HSA-157858	3.102249e-04	3.508
Degradation of CDH1	R-HSA-9766229	3.102249e-04	3.508
TCF dependent signaling in response to WNT	R-HSA-201681	3.244415e-04	3.489
MTOR signalling	R-HSA-165159	3.318960e-04	3.479
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.326304e-04	3.478
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.326304e-04	3.478
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.348379e-04	3.475
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.362942e-04	3.473
RET signaling	R-HSA-8853659	3.401031e-04	3.468
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.548207e-04	3.450
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.644174e-04	3.438
Peptide chain elongation	R-HSA-156902	4.007630e-04	3.397
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.860307e-04	3.413
MAPK6/MAPK4 signaling	R-HSA-5687128	4.026524e-04	3.395
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.038025e-04	3.394
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.228377e-04	3.374
TCR signaling	R-HSA-202403	4.229708e-04	3.374
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.474119e-04	3.349
Degradation of DVL	R-HSA-4641258	4.474119e-04	3.349
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.530311e-04	3.344
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.633003e-04	3.334
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.740650e-04	3.324
G1/S Transition	R-HSA-69206	4.967636e-04	3.304
RAF activation	R-HSA-5673000	5.163330e-04	3.287
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.163330e-04	3.287
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.163330e-04	3.287
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.195410e-04	3.284
Mitotic Spindle Checkpoint	R-HSA-69618	5.329575e-04	3.273
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.456231e-04	3.263
Gap junction trafficking	R-HSA-190828	5.456231e-04	3.263
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	5.639837e-04	3.249
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.714021e-04	3.243
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.714021e-04	3.243
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.657188e-04	3.177
Orc1 removal from chromatin	R-HSA-68949	6.173447e-04	3.209
Regulation of T cell activation by CD28 family	R-HSA-388841	6.146484e-04	3.211
Transcriptional regulation by RUNX3	R-HSA-8878159	6.388425e-04	3.195
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.776099e-04	3.169
Signalling to ERKs	R-HSA-187687	6.776099e-04	3.169
Signaling by Hippo	R-HSA-2028269	7.018670e-04	3.154
Cell-extracellular matrix interactions	R-HSA-446353	7.166118e-04	3.145
MAPK family signaling cascades	R-HSA-5683057	7.170038e-04	3.144
Regulation of endogenous retroelements	R-HSA-9842860	7.269406e-04	3.139
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.331096e-04	3.135
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.331096e-04	3.135
Regulation of TP53 Activity	R-HSA-5633007	7.466065e-04	3.127
Regulation of PTEN stability and activity	R-HSA-8948751	7.665812e-04	3.115
Meiotic synapsis	R-HSA-1221632	7.665812e-04	3.115
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.665812e-04	3.115
ER to Golgi Anterograde Transport	R-HSA-199977	7.690571e-04	3.114
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.844222e-04	3.105
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	9.023638e-04	3.045
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.033704e-04	3.044
PRC2 methylates histones and DNA	R-HSA-212300	8.803595e-04	3.055
Signaling by RAS mutants	R-HSA-6802949	8.699370e-04	3.061
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.699370e-04	3.061
Signaling downstream of RAS mutants	R-HSA-9649948	8.699370e-04	3.061
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.699370e-04	3.061
HATs acetylate histones	R-HSA-3214847	8.711553e-04	3.060
Regulation of RAS by GAPs	R-HSA-5658442	9.129170e-04	3.040
Switching of origins to a post-replicative state	R-HSA-69052	8.315622e-04	3.080
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.461302e-04	3.024
rRNA processing	R-HSA-72312	8.803749e-04	3.055
SARS-CoV-2-host interactions	R-HSA-9705683	9.345709e-04	3.029
Amplification of signal from the kinetochores	R-HSA-141424	9.583558e-04	3.018
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.583558e-04	3.018
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.627318e-04	3.016
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.627318e-04	3.016
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	9.703514e-04	3.013
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.740778e-04	3.011
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.806480e-04	3.008
AURKA Activation by TPX2	R-HSA-8854518	9.952295e-04	3.002
Degradation of beta-catenin by the destruction complex	R-HSA-195253	9.976072e-04	3.001
Vpu mediated degradation of CD4	R-HSA-180534	1.026716e-03	2.989
EPHA-mediated growth cone collapse	R-HSA-3928663	1.033556e-03	2.986
RNA Polymerase I Promoter Opening	R-HSA-73728	1.033556e-03	2.986
PECAM1 interactions	R-HSA-210990	1.043038e-03	2.982
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.132859e-03	2.946
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.160895e-03	2.935
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.172577e-03	2.931
Protein ubiquitination	R-HSA-8852135	1.184229e-03	2.927
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.192614e-03	2.924
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.192614e-03	2.924
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.193606e-03	2.923
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.193606e-03	2.923
Regulation of mitotic cell cycle	R-HSA-453276	1.193763e-03	2.923
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.193763e-03	2.923
FLT3 Signaling	R-HSA-9607240	1.221413e-03	2.913
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.221413e-03	2.913
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.221413e-03	2.913
Transcriptional Regulation by TP53	R-HSA-3700989	1.266571e-03	2.897
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.273904e-03	2.895
Chaperonin-mediated protein folding	R-HSA-390466	1.322700e-03	2.879
Signaling by RAF1 mutants	R-HSA-9656223	1.537092e-03	2.813
mRNA 3'-end processing	R-HSA-72187	1.388937e-03	2.857
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.455186e-03	2.837
HCMV Early Events	R-HSA-9609690	1.359466e-03	2.867
Clathrin-mediated endocytosis	R-HSA-8856828	1.381516e-03	2.860
Vesicle-mediated transport	R-HSA-5653656	1.440695e-03	2.841
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.329857e-03	2.876
Nuclear import of Rev protein	R-HSA-180746	1.329857e-03	2.876
Diseases of programmed cell death	R-HSA-9645723	1.546226e-03	2.811
Developmental Biology	R-HSA-1266738	1.365148e-03	2.865
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.449819e-03	2.839
DNA Replication	R-HSA-69306	1.565857e-03	2.805
Oncogenic MAPK signaling	R-HSA-6802957	1.587972e-03	2.799
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.608951e-03	2.793
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.608951e-03	2.793
p75 NTR receptor-mediated signalling	R-HSA-193704	1.626676e-03	2.789
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.663721e-03	2.779
Oncogene Induced Senescence	R-HSA-2559585	1.705445e-03	2.768
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.705445e-03	2.768
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.705445e-03	2.768
Nectin/Necl trans heterodimerization	R-HSA-420597	1.725446e-03	2.763
FLT3 signaling by CBL mutants	R-HSA-9706377	1.725446e-03	2.763
Protein folding	R-HSA-391251	1.744865e-03	2.758
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.801974e-03	2.744
Hedgehog 'off' state	R-HSA-5610787	1.875242e-03	2.727
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.919388e-03	2.717
Neutrophil degranulation	R-HSA-6798695	1.978971e-03	2.704
Signaling by NOTCH4	R-HSA-9013694	1.995030e-03	2.700
IPs transport between nucleus and cytosol	R-HSA-1855170	2.009228e-03	2.697
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.009228e-03	2.697
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.055071e-03	2.687
Signaling by EGFR in Cancer	R-HSA-1643713	2.105594e-03	2.677
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.166490e-03	2.664
Interactions of Rev with host cellular proteins	R-HSA-177243	2.288699e-03	2.640
Downregulation of ERBB2 signaling	R-HSA-8863795	2.360695e-03	2.627
p75NTR signals via NF-kB	R-HSA-193639	2.434506e-03	2.614
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.434506e-03	2.614
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.434506e-03	2.614
G1/S DNA Damage Checkpoints	R-HSA-69615	2.471987e-03	2.607
Activation of NF-kappaB in B cells	R-HSA-1169091	2.477727e-03	2.606
Apoptosis induced DNA fragmentation	R-HSA-140342	2.532743e-03	2.596
MAPK1/MAPK3 signaling	R-HSA-5684996	2.554180e-03	2.593
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.567056e-03	2.591
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.596207e-03	2.586
Basigin interactions	R-HSA-210991	2.774856e-03	2.557
Packaging Of Telomere Ends	R-HSA-171306	2.763914e-03	2.558
Ovarian tumor domain proteases	R-HSA-5689896	2.727444e-03	2.564
G1 Phase	R-HSA-69236	2.927573e-03	2.533
Cyclin D associated events in G1	R-HSA-69231	2.927573e-03	2.533
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.886422e-03	2.540
Signaling by EGFR	R-HSA-177929	2.996613e-03	2.523
UCH proteinases	R-HSA-5689603	2.754560e-03	2.560
Proteasome assembly	R-HSA-9907900	2.927573e-03	2.533
Meiosis	R-HSA-1500620	3.013864e-03	2.521
Co-stimulation by CD28	R-HSA-389356	2.976850e-03	2.526
RAF/MAP kinase cascade	R-HSA-5673001	3.128734e-03	2.505
Eukaryotic Translation Termination	R-HSA-72764	3.088034e-03	2.510
Transcriptional Regulation by VENTX	R-HSA-8853884	2.846037e-03	2.546
HIV Infection	R-HSA-162906	3.106105e-03	2.508
Hh mutants are degraded by ERAD	R-HSA-5362768	2.846037e-03	2.546
Death Receptor Signaling	R-HSA-73887	2.872291e-03	2.542
Degradation of AXIN	R-HSA-4641257	2.727444e-03	2.564
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.727444e-03	2.564
SARS-CoV-1 Infection	R-HSA-9678108	2.630088e-03	2.580
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.134874e-03	2.504
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.134874e-03	2.504
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.247716e-03	2.488
Gap junction assembly	R-HSA-190861	3.247716e-03	2.488
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.312783e-03	2.480
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.404211e-03	2.468
Negative regulation of MAPK pathway	R-HSA-5675221	3.512125e-03	2.454
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.512125e-03	2.454
Degradation of GLI2 by the proteasome	R-HSA-5610783	3.512125e-03	2.454
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	3.512125e-03	2.454
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.578007e-03	2.446
Asymmetric localization of PCP proteins	R-HSA-4608870	3.578007e-03	2.446
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.730772e-03	2.428
PCP/CE pathway	R-HSA-4086400	3.746979e-03	2.426
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.838888e-03	2.416
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.846875e-03	2.415
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.846875e-03	2.415
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.937676e-03	2.405
Signaling by NTRKs	R-HSA-166520	3.989660e-03	2.399
Sema4D in semaphorin signaling	R-HSA-400685	4.213813e-03	2.375
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.214126e-03	2.375
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.214126e-03	2.375
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.214126e-03	2.375
Signaling by WNT	R-HSA-195721	4.291146e-03	2.367
Centrosome maturation	R-HSA-380287	4.504495e-03	2.346
Cilium Assembly	R-HSA-5617833	4.555076e-03	2.342
DNA methylation	R-HSA-5334118	4.588588e-03	2.338
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.588588e-03	2.338
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.847304e-03	2.314
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	4.861677e-03	2.313
Metabolism of non-coding RNA	R-HSA-194441	5.045375e-03	2.297
snRNP Assembly	R-HSA-191859	5.045375e-03	2.297
Regulation of TP53 Degradation	R-HSA-6804757	5.057119e-03	2.296
Meiotic recombination	R-HSA-912446	5.206863e-03	2.283
TBC/RABGAPs	R-HSA-8854214	5.233682e-03	2.281
Defective pyroptosis	R-HSA-9710421	5.233682e-03	2.281
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.233682e-03	2.281
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.240926e-03	2.281
Gene Silencing by RNA	R-HSA-211000	5.331692e-03	2.273
Signal regulatory protein family interactions	R-HSA-391160	5.419849e-03	2.266
Nephrin family interactions	R-HSA-373753	5.746667e-03	2.241
DAP12 signaling	R-HSA-2424491	5.811767e-03	2.236
Activation of BH3-only proteins	R-HSA-114452	5.811767e-03	2.236
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.878995e-03	2.231
NF-kB is activated and signals survival	R-HSA-209560	5.878995e-03	2.231
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.878995e-03	2.231
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.878995e-03	2.231
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.908752e-03	2.229
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.908752e-03	2.229
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.908752e-03	2.229
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.908752e-03	2.229
Glycolysis	R-HSA-70171	5.925427e-03	2.227
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.635862e-03	2.178
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.635862e-03	2.178
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.431450e-03	2.192
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.309653e-03	2.200
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.202110e-03	2.207
RNA Polymerase I Promoter Escape	R-HSA-73772	6.202110e-03	2.207
RNA Polymerase II Transcription Termination	R-HSA-73856	6.970683e-03	2.157
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.240458e-03	2.205
Nucleotide Excision Repair	R-HSA-5696398	7.146720e-03	2.146
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.935360e-03	2.159
Epigenetic regulation of gene expression	R-HSA-212165	6.329180e-03	2.199
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.309653e-03	2.200
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.501546e-03	2.125
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.554383e-03	2.122
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.554383e-03	2.122
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.569542e-03	2.121
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.569542e-03	2.121
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	7.569542e-03	2.121
Degradation of CRY and PER proteins	R-HSA-9932298	7.636605e-03	2.117
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.473853e-03	2.072
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.473853e-03	2.072
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	8.473853e-03	2.072
p75NTR recruits signalling complexes	R-HSA-209543	8.473853e-03	2.072
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.719562e-03	2.060
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.875166e-03	2.052
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.037419e-03	2.044
MET activates RAP1 and RAC1	R-HSA-8875555	9.199109e-03	2.036
Folding of actin by CCT/TriC	R-HSA-390450	9.199109e-03	2.036
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	9.199109e-03	2.036
Josephin domain DUBs	R-HSA-5689877	9.199109e-03	2.036
Regulation of PTEN localization	R-HSA-8948747	9.452679e-03	2.024
Cohesin Loading onto Chromatin	R-HSA-2470946	9.452679e-03	2.024
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.459633e-03	2.024
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.736710e-03	2.012
Signaling by PDGFR in disease	R-HSA-9671555	9.828183e-03	2.008
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.828183e-03	2.008
Antigen processing-Cross presentation	R-HSA-1236975	1.006610e-02	1.997
Negative regulation of FLT3	R-HSA-9706369	1.031526e-02	1.987
Prolonged ERK activation events	R-HSA-169893	1.031526e-02	1.987
Hedgehog ligand biogenesis	R-HSA-5358346	1.046654e-02	1.980
Golgi-to-ER retrograde transport	R-HSA-8856688	1.058054e-02	1.975
ER-Phagosome pathway	R-HSA-1236974	1.061382e-02	1.974
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.069800e-02	1.971
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.110804e-02	1.954
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.110804e-02	1.954
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.111133e-02	1.954
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.111133e-02	1.954
GPVI-mediated activation cascade	R-HSA-114604	1.116960e-02	1.952
Selenocysteine synthesis	R-HSA-2408557	1.132555e-02	1.946
Kinesins	R-HSA-983189	1.140597e-02	1.943
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.148922e-02	1.940
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.165178e-02	1.934
STING mediated induction of host immune responses	R-HSA-1834941	1.165178e-02	1.934
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.184285e-02	1.927
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.192944e-02	1.923
SARS-CoV Infections	R-HSA-9679506	1.223055e-02	1.913
Cellular response to hypoxia	R-HSA-1234174	1.262251e-02	1.899
Signaling by NOTCH	R-HSA-157118	1.270917e-02	1.896
MAP kinase activation	R-HSA-450294	1.319518e-02	1.880
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.332811e-02	1.875
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.343668e-02	1.872
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.346665e-02	1.871
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.346665e-02	1.871
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.353131e-02	1.869
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.374935e-02	1.862
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.374935e-02	1.862
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	1.374935e-02	1.862
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.374935e-02	1.862
Viral mRNA Translation	R-HSA-192823	1.413350e-02	1.850
Smooth Muscle Contraction	R-HSA-445355	1.431810e-02	1.844
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.448281e-02	1.839
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.468270e-02	1.833
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.468270e-02	1.833
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.478914e-02	1.830
Synthesis of DNA	R-HSA-69239	1.478914e-02	1.830
Negative regulation of MET activity	R-HSA-6807004	1.503900e-02	1.823
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.503900e-02	1.823
Co-inhibition by CTLA4	R-HSA-389513	1.503900e-02	1.823
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.533782e-02	1.814
Co-inhibition by PD-1	R-HSA-389948	1.559577e-02	1.807
Inactivation of CDC42 and RAC1	R-HSA-428543	2.112526e-02	1.675
Gap junction degradation	R-HSA-190873	2.112526e-02	1.675
Calcineurin activates NFAT	R-HSA-2025928	2.112526e-02	1.675
ALK mutants bind TKIs	R-HSA-9700645	2.112526e-02	1.675
Signaling by AMER1 mutants	R-HSA-4839748	1.864123e-02	1.730
Signaling by GSK3beta mutants	R-HSA-5339716	1.864123e-02	1.730
Signalling to RAS	R-HSA-167044	1.910967e-02	1.719
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.910967e-02	1.719
Downstream signal transduction	R-HSA-186763	1.641381e-02	1.785
G0 and Early G1	R-HSA-1538133	1.986663e-02	1.702
Diseases of mitotic cell cycle	R-HSA-9675126	1.986663e-02	1.702
Condensation of Prophase Chromosomes	R-HSA-2299718	1.798322e-02	1.745
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.096679e-02	1.678
Chromosome Maintenance	R-HSA-73886	1.824492e-02	1.739
Neurodegenerative Diseases	R-HSA-8863678	1.972228e-02	1.705
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.972228e-02	1.705
Transcriptional Regulation by E2F6	R-HSA-8953750	1.914543e-02	1.718
GP1b-IX-V activation signalling	R-HSA-430116	2.112526e-02	1.675
MyD88-independent TLR4 cascade	R-HSA-166166	2.008829e-02	1.697
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.008829e-02	1.697
Mitophagy	R-HSA-5205647	1.634377e-02	1.787
Integration of provirus	R-HSA-162592	1.864123e-02	1.730
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.593139e-02	1.798
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.112526e-02	1.675
Platelet activation, signaling and aggregation	R-HSA-76002	1.718876e-02	1.765
Regulation of KIT signaling	R-HSA-1433559	1.610608e-02	1.793
Interleukin-1 signaling	R-HSA-9020702	1.861118e-02	1.730
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.009290e-02	1.697
Immune System	R-HSA-168256	1.787338e-02	1.748
Cellular response to chemical stress	R-HSA-9711123	1.606196e-02	1.794
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.798322e-02	1.745
Signaling by Hedgehog	R-HSA-5358351	2.024198e-02	1.694
Viral Infection Pathways	R-HSA-9824446	1.885309e-02	1.725
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.986663e-02	1.702
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.137910e-02	1.670
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.137910e-02	1.670
Spry regulation of FGF signaling	R-HSA-1295596	2.137910e-02	1.670
Signaling by SCF-KIT	R-HSA-1433557	2.180793e-02	1.661
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.199528e-02	1.658
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.232421e-02	1.651
Interleukin-2 family signaling	R-HSA-451927	2.259121e-02	1.646
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.276608e-02	1.643
Nef and signal transduction	R-HSA-164944	2.298154e-02	1.639
Platelet sensitization by LDL	R-HSA-432142	2.304612e-02	1.637
FLT3 signaling in disease	R-HSA-9682385	2.328282e-02	1.633
Regulation of MECP2 expression and activity	R-HSA-9022692	2.383710e-02	1.623
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.393446e-02	1.621
Signaling by Erythropoietin	R-HSA-9006335	2.419208e-02	1.616
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.419208e-02	1.616
Late endosomal microautophagy	R-HSA-9615710	2.419208e-02	1.616
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.528595e-02	1.597
VLDLR internalisation and degradation	R-HSA-8866427	2.528595e-02	1.597
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.528595e-02	1.597
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.528595e-02	1.597
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.528595e-02	1.597
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.528595e-02	1.597
Signaling by LTK	R-HSA-9842663	2.528595e-02	1.597
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.529009e-02	1.597
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.648340e-02	1.577
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.648340e-02	1.577
Hedgehog 'on' state	R-HSA-5632684	2.735502e-02	1.563
Cleavage of the damaged purine	R-HSA-110331	2.748151e-02	1.561
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.754489e-02	1.560
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.907455e-02	1.536
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.907455e-02	1.536
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.945463e-02	1.531
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.945463e-02	1.531
Somitogenesis	R-HSA-9824272	2.945463e-02	1.531
Myogenesis	R-HSA-525793	2.952018e-02	1.530
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.957173e-02	1.529
PI3K/AKT activation	R-HSA-198203	2.957173e-02	1.529
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.957173e-02	1.529
SARS-CoV-2 Infection	R-HSA-9694516	2.990928e-02	1.524
Rab regulation of trafficking	R-HSA-9007101	3.006740e-02	1.522
Adaptive Immune System	R-HSA-1280218	3.019759e-02	1.520
MAP2K and MAPK activation	R-HSA-5674135	3.085260e-02	1.511
HIV Life Cycle	R-HSA-162587	3.180319e-02	1.498
Depurination	R-HSA-73927	3.221256e-02	1.492
Downstream TCR signaling	R-HSA-202424	3.280808e-02	1.484
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.283162e-02	1.484
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.339118e-02	1.476
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.339118e-02	1.476
MHC class II antigen presentation	R-HSA-2132295	3.346580e-02	1.475
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.383139e-02	1.471
Cellular response to starvation	R-HSA-9711097	3.427759e-02	1.465
EGFR downregulation	R-HSA-182971	3.463167e-02	1.461
Diseases of Cellular Senescence	R-HSA-9630747	3.481983e-02	1.458
Diseases of cellular response to stress	R-HSA-9675132	3.481983e-02	1.458
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.481983e-02	1.458
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.495036e-02	1.457
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.495036e-02	1.457
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.495036e-02	1.457
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.554509e-02	1.449
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.554509e-02	1.449
Cleavage of the damaged pyrimidine	R-HSA-110329	3.572813e-02	1.447
Depyrimidination	R-HSA-73928	3.572813e-02	1.447
Interleukin receptor SHC signaling	R-HSA-912526	3.610867e-02	1.442
Syndecan interactions	R-HSA-3000170	3.610867e-02	1.442
Signaling by Nuclear Receptors	R-HSA-9006931	3.621710e-02	1.441
Beta-catenin independent WNT signaling	R-HSA-3858494	3.795409e-02	1.421
Muscle contraction	R-HSA-397014	3.836281e-02	1.416
Potential therapeutics for SARS	R-HSA-9679191	3.909671e-02	1.408
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.925233e-02	1.406
Signaling by APC mutants	R-HSA-4839744	3.997407e-02	1.398
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.997407e-02	1.398
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.997407e-02	1.398
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.997407e-02	1.398
Interleukin-17 signaling	R-HSA-448424	4.103665e-02	1.387
Signaling by FGFR4	R-HSA-5654743	4.113764e-02	1.386
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.181793e-02	1.379
Formation of editosomes by ADAR proteins	R-HSA-77042	4.936676e-02	1.307
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	4.936676e-02	1.307
MET interacts with TNS proteins	R-HSA-8875513	5.991938e-02	1.222
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.991938e-02	1.222
MET activates PTPN11	R-HSA-8865999	5.991938e-02	1.222
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.497578e-02	1.260
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.740115e-02	1.324
Formation of annular gap junctions	R-HSA-196025	4.740115e-02	1.324
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.376748e-02	1.195
ARMS-mediated activation	R-HSA-170984	6.376748e-02	1.195
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.376748e-02	1.195
Activation of RAC1	R-HSA-428540	5.243857e-02	1.280
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.306256e-02	1.366
Erythropoietin activates RAS	R-HSA-9027284	5.437885e-02	1.265
p38MAPK events	R-HSA-171007	5.437885e-02	1.265
Beta-catenin phosphorylation cascade	R-HSA-196299	5.437885e-02	1.265
Polo-like kinase mediated events	R-HSA-156711	5.452020e-02	1.263
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.429364e-02	1.354
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.357440e-02	1.361
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.359189e-02	1.271
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.359189e-02	1.271
Long-term potentiation	R-HSA-9620244	5.202419e-02	1.284
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.081360e-02	1.294
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.027387e-02	1.220
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.273449e-02	1.202
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	5.541889e-02	1.256
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.452020e-02	1.263
Signaling by MET	R-HSA-6806834	4.436077e-02	1.353
CaM pathway	R-HSA-111997	4.567960e-02	1.340
Calmodulin induced events	R-HSA-111933	4.567960e-02	1.340
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.254224e-02	1.279
DAG and IP3 signaling	R-HSA-1489509	5.365844e-02	1.270
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.452020e-02	1.263
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.027387e-02	1.220
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.008129e-02	1.300
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.008129e-02	1.300
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.497578e-02	1.260
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.376748e-02	1.195
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.376748e-02	1.195
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.359189e-02	1.271
Response of endothelial cells to shear stress	R-HSA-9860931	5.952904e-02	1.225
Signaling by FGFR3	R-HSA-5654741	5.365844e-02	1.270
Gene expression (Transcription)	R-HSA-74160	4.272009e-02	1.369
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.254224e-02	1.279
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.663757e-02	1.247
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.092460e-02	1.215
NRIF signals cell death from the nucleus	R-HSA-205043	4.306256e-02	1.366
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.991385e-02	1.302
HCMV Infection	R-HSA-9609646	4.531457e-02	1.344
Regulation of necroptotic cell death	R-HSA-5675482	4.793039e-02	1.319
Downregulation of ERBB4 signaling	R-HSA-1253288	4.740115e-02	1.324
PKMTs methylate histone lysines	R-HSA-3214841	4.991385e-02	1.302
DAP12 interactions	R-HSA-2172127	4.710669e-02	1.327
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.342656e-02	1.198
Interleukin-1 family signaling	R-HSA-446652	4.523156e-02	1.345
Signaling by AXIN mutants	R-HSA-4839735	5.243857e-02	1.280
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.149563e-02	1.211
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.359189e-02	1.271
Glucose metabolism	R-HSA-70326	4.525765e-02	1.344
Transcriptional Regulation by MECP2	R-HSA-8986944	5.663757e-02	1.247
Transcriptional regulation by RUNX2	R-HSA-8878166	5.313890e-02	1.275
Modulation by Mtb of host immune system	R-HSA-9637628	4.740115e-02	1.324
Maturation of protein E	R-HSA-9694493	5.497578e-02	1.260
Maturation of protein E	R-HSA-9683683	5.497578e-02	1.260
Dual Incision in GG-NER	R-HSA-5696400	6.436335e-02	1.191
Ca-dependent events	R-HSA-111996	6.490447e-02	1.188
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.527015e-02	1.185
Translesion Synthesis by POLH	R-HSA-110320	6.617422e-02	1.179
Transport to the Golgi and subsequent modification	R-HSA-948021	6.644677e-02	1.178
NRAGE signals death through JNK	R-HSA-193648	6.693734e-02	1.174
AKT phosphorylates targets in the cytosol	R-HSA-198323	6.702301e-02	1.174
SHC-related events triggered by IGF1R	R-HSA-2428933	6.702301e-02	1.174
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.738971e-02	1.171
Phosphorylation of the APC/C	R-HSA-176412	6.738971e-02	1.171
Regulation of NF-kappa B signaling	R-HSA-9758274	6.738971e-02	1.171
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.817439e-02	1.166
Hemostasis	R-HSA-109582	6.819189e-02	1.166
Viral Messenger RNA Synthesis	R-HSA-168325	6.942963e-02	1.158
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.942963e-02	1.158
Organelle biogenesis and maintenance	R-HSA-1852241	6.952946e-02	1.158
Interaction between L1 and Ankyrins	R-HSA-445095	7.201632e-02	1.143
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.201632e-02	1.143
Telomere Maintenance	R-HSA-157579	7.427617e-02	1.129
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.427617e-02	1.129
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.577469e-02	1.120
tRNA processing in the nucleus	R-HSA-6784531	7.692053e-02	1.114
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.692053e-02	1.114
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.777100e-02	1.109
Generation of second messenger molecules	R-HSA-202433	7.859071e-02	1.105
Base Excision Repair	R-HSA-73884	7.881647e-02	1.103
Signal transduction by L1	R-HSA-445144	7.925433e-02	1.101
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.074602e-02	1.093
Signal attenuation	R-HSA-74749	8.291806e-02	1.081
2-LTR circle formation	R-HSA-164843	8.291806e-02	1.081
Regulation of CDH11 function	R-HSA-9762292	8.291806e-02	1.081
Pexophagy	R-HSA-9664873	8.291806e-02	1.081
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.360326e-02	1.078
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.373634e-02	1.077
Frs2-mediated activation	R-HSA-170968	8.373634e-02	1.077
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.869858e-02	1.052
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.869858e-02	1.052
Deadenylation of mRNA	R-HSA-429947	8.869858e-02	1.052
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.982868e-02	1.047
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	9.001079e-02	1.046
Integrin signaling	R-HSA-354192	9.001079e-02	1.046
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	9.001079e-02	1.046
Regulation of gap junction activity	R-HSA-191650	9.134805e-02	1.039
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	9.134805e-02	1.039
Inhibition of TSC complex formation by PKB	R-HSA-165181	9.134805e-02	1.039
PLCG1 events in ERBB2 signaling	R-HSA-1251932	9.134805e-02	1.039
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	9.134805e-02	1.039
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.254936e-02	1.034
Early Phase of HIV Life Cycle	R-HSA-162594	9.376475e-02	1.028
Cellular responses to mechanical stimuli	R-HSA-9855142	9.462678e-02	1.024
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	9.527356e-02	1.021
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	9.919626e-02	1.004
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	9.919626e-02	1.004
Manipulation of host energy metabolism	R-HSA-9636667	9.919626e-02	1.004
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	9.919626e-02	1.004
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	9.919626e-02	1.004
Breakdown of the nuclear lamina	R-HSA-352238	9.919626e-02	1.004
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.025406e-01	0.989
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.025406e-01	0.989
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.025406e-01	0.989
Signaling by FGFR4 in disease	R-HSA-5655291	1.025406e-01	0.989
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.028460e-01	0.988
RUNX3 regulates WNT signaling	R-HSA-8951430	1.029760e-01	0.987
MET activates PI3K/AKT signaling	R-HSA-8851907	1.029760e-01	0.987
SOS-mediated signalling	R-HSA-112412	1.029760e-01	0.987
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.029760e-01	0.987
CHL1 interactions	R-HSA-447041	1.029760e-01	0.987
Regulation of TNFR1 signaling	R-HSA-5357905	1.031777e-01	0.986
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.047595e-01	0.980
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.052848e-01	0.978
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.052848e-01	0.978
Signaling by FGFR2	R-HSA-5654738	1.062828e-01	0.974
MET promotes cell motility	R-HSA-8875878	1.072831e-01	0.969
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.072831e-01	0.969
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.085342e-01	0.964
TNF signaling	R-HSA-75893	1.085342e-01	0.964
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.085342e-01	0.964
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.096894e-01	0.960
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.096894e-01	0.960
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.096894e-01	0.960
Formation of paraxial mesoderm	R-HSA-9793380	1.105082e-01	0.957
GAB1 signalosome	R-HSA-180292	1.166359e-01	0.933
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.166359e-01	0.933
Formation of RNA Pol II elongation complex	R-HSA-112382	1.171320e-01	0.931
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.182000e-01	0.927
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.182000e-01	0.927
Late Phase of HIV Life Cycle	R-HSA-162599	1.197188e-01	0.922
Signaling by ALK	R-HSA-201556	1.201410e-01	0.920
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.233545e-01	0.909
DCC mediated attractive signaling	R-HSA-418885	1.233545e-01	0.909
Translesion synthesis by REV1	R-HSA-110312	1.233545e-01	0.909
Protein methylation	R-HSA-8876725	1.233545e-01	0.909
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.237176e-01	0.908
Trafficking of AMPA receptors	R-HSA-399719	1.247667e-01	0.904
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.265558e-01	0.898
Intraflagellar transport	R-HSA-5620924	1.265558e-01	0.898
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.269927e-01	0.896
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.269927e-01	0.896
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.269927e-01	0.896
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.281504e-01	0.892
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.281504e-01	0.892
IRS activation	R-HSA-74713	1.281504e-01	0.892
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.281504e-01	0.892
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.281504e-01	0.892
NrCAM interactions	R-HSA-447038	1.281504e-01	0.892
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.287935e-01	0.890
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.287935e-01	0.890
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.291285e-01	0.889
Reproduction	R-HSA-1474165	1.293442e-01	0.888
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.298659e-01	0.887
Type I hemidesmosome assembly	R-HSA-446107	1.322734e-01	0.879
Signaling by MRAS-complex mutants	R-HSA-9660537	1.322734e-01	0.879
MET receptor recycling	R-HSA-8875656	1.322734e-01	0.879
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.322734e-01	0.879
Adrenoceptors	R-HSA-390696	1.322734e-01	0.879
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.322734e-01	0.879
Activation of HOX genes during differentiation	R-HSA-5619507	1.333302e-01	0.875
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.333302e-01	0.875
ABC-family proteins mediated transport	R-HSA-382556	1.337517e-01	0.874
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.347295e-01	0.871
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.363264e-01	0.865
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.369152e-01	0.864
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.390209e-01	0.857
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.405688e-01	0.852
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.410938e-01	0.850
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.410938e-01	0.850
Drug resistance of FLT3 mutants	R-HSA-9702506	1.617444e-01	0.791
Drug resistance of PDGFR mutants	R-HSA-9674415	1.617444e-01	0.791
FLT3 mutants bind TKIs	R-HSA-9702509	1.617444e-01	0.791
PDGFR mutants bind TKIs	R-HSA-9674428	1.617444e-01	0.791
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.617444e-01	0.791
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.617444e-01	0.791
sunitinib-resistant FLT3 mutants	R-HSA-9702632	1.617444e-01	0.791
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.617444e-01	0.791
crenolanib-resistant FLT3 mutants	R-HSA-9702581	1.617444e-01	0.791
tamatinib-resistant FLT3 mutants	R-HSA-9703009	1.617444e-01	0.791
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.617444e-01	0.791
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.617444e-01	0.791
ponatinib-resistant FLT3 mutants	R-HSA-9702614	1.617444e-01	0.791
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.617444e-01	0.791
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.617444e-01	0.791
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	1.617444e-01	0.791
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	1.617444e-01	0.791
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.617444e-01	0.791
tandutinib-resistant FLT3 mutants	R-HSA-9702636	1.617444e-01	0.791
semaxanib-resistant FLT3 mutants	R-HSA-9702577	1.617444e-01	0.791
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.617444e-01	0.791
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.617444e-01	0.791
linifanib-resistant FLT3 mutants	R-HSA-9702998	1.617444e-01	0.791
KW2449-resistant FLT3 mutants	R-HSA-9702569	1.617444e-01	0.791
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	1.617444e-01	0.791
midostaurin-resistant FLT3 mutants	R-HSA-9702600	1.617444e-01	0.791
sorafenib-resistant FLT3 mutants	R-HSA-9702624	1.617444e-01	0.791
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.617444e-01	0.791
quizartinib-resistant FLT3 mutants	R-HSA-9702620	1.617444e-01	0.791
mRNA Editing: A to I Conversion	R-HSA-75064	1.577785e-01	0.802
Regulation of TP53 Expression	R-HSA-6804754	1.577785e-01	0.802
C6 deamination of adenosine	R-HSA-75102	1.577785e-01	0.802
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.577785e-01	0.802
Regulation of cortical dendrite branching	R-HSA-8985801	1.577785e-01	0.802
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.577785e-01	0.802
TRKA activation by NGF	R-HSA-187042	2.209804e-01	0.656
PLC-gamma1 signalling	R-HSA-167021	2.209804e-01	0.656
Axonal growth stimulation	R-HSA-209563	2.209804e-01	0.656
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.209804e-01	0.656
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	2.209804e-01	0.656
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.209804e-01	0.656
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.209804e-01	0.656
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.692318e-01	0.772
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.692318e-01	0.772
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.645423e-01	0.784
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.645423e-01	0.784
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.134744e-01	0.671
Signaling by LTK in cancer	R-HSA-9842640	2.134744e-01	0.671
STAT5 Activation	R-HSA-9645135	2.134744e-01	0.671
G2/M DNA replication checkpoint	R-HSA-69478	2.134744e-01	0.671
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.857764e-01	0.544
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.857764e-01	0.544
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.857764e-01	0.544
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.857764e-01	0.544
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.857764e-01	0.544
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.558044e-01	0.807
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.558044e-01	0.807
IRAK1 recruits IKK complex	R-HSA-937039	1.558044e-01	0.807
Scavenging by Class F Receptors	R-HSA-3000484	1.558044e-01	0.807
Receptor Mediated Mitophagy	R-HSA-8934903	1.992845e-01	0.701
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	1.992845e-01	0.701
Translesion synthesis by POLI	R-HSA-5656121	1.460585e-01	0.835
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.460585e-01	0.835
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.598110e-01	0.585
Disinhibition of SNARE formation	R-HSA-114516	2.598110e-01	0.585
Recycling of eIF2:GDP	R-HSA-72731	2.598110e-01	0.585
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.845227e-01	0.734
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.845227e-01	0.734
CD28 dependent Vav1 pathway	R-HSA-389359	1.845227e-01	0.734
Translesion synthesis by POLK	R-HSA-5655862	1.705002e-01	0.768
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.705002e-01	0.768
Activated NTRK3 signals through RAS	R-HSA-9034864	2.359762e-01	0.627
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.575240e-01	0.803
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.575240e-01	0.803
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.575240e-01	0.803
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.575240e-01	0.803
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.575240e-01	0.803
PI3K events in ERBB2 signaling	R-HSA-1963642	1.965012e-01	0.707
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.965012e-01	0.707
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.740924e-01	0.562
Activated NTRK2 signals through RAS	R-HSA-9026519	2.740924e-01	0.562
Proton-coupled monocarboxylate transport	R-HSA-433692	2.740924e-01	0.562
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	2.740924e-01	0.562
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.468871e-01	0.608
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.468871e-01	0.608
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.468871e-01	0.608
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.468871e-01	0.608
ATP-dependent chromatin remodelers	R-HSA-9932444	1.865515e-01	0.729
SWI/SNF chromatin remodelers	R-HSA-9932451	1.865515e-01	0.729
Tight junction interactions	R-HSA-420029	1.865515e-01	0.729
Termination of translesion DNA synthesis	R-HSA-5656169	1.711253e-01	0.767
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.711253e-01	0.767
G1/S-Specific Transcription	R-HSA-69205	1.449945e-01	0.839
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	2.289562e-01	0.640
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.798980e-01	0.553
RNA Polymerase I Transcription Termination	R-HSA-73863	2.317486e-01	0.635
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.655086e-01	0.781
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.818125e-01	0.550
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.675551e-01	0.776
TRAF6 mediated NF-kB activation	R-HSA-933542	2.816595e-01	0.550
G-protein beta:gamma signalling	R-HSA-397795	2.553113e-01	0.593
Dual incision in TC-NER	R-HSA-6782135	1.963663e-01	0.707
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.088058e-01	0.680
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.728357e-01	0.564
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.202762e-01	0.657
DNA Damage Bypass	R-HSA-73893	2.134813e-01	0.671
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.329176e-01	0.633
Regulation of gene expression in beta cells	R-HSA-210745	1.711253e-01	0.767
Downstream signaling of activated FGFR3	R-HSA-5654708	2.803085e-01	0.552
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.253835e-01	0.647
Killing mechanisms	R-HSA-9664420	1.460585e-01	0.835
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	1.460585e-01	0.835
IGF1R signaling cascade	R-HSA-2428924	2.102838e-01	0.677
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.853998e-01	0.545
Interferon alpha/beta signaling	R-HSA-909733	2.115551e-01	0.675
PLC beta mediated events	R-HSA-112043	2.435265e-01	0.613
Fanconi Anemia Pathway	R-HSA-6783310	2.319876e-01	0.635
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.134744e-01	0.671
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.908667e-01	0.719
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.534849e-01	0.814
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.485390e-01	0.828
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.656810e-01	0.781
EGFR Transactivation by Gastrin	R-HSA-2179392	1.992845e-01	0.701
DARPP-32 events	R-HSA-180024	1.711253e-01	0.767
Metalloprotease DUBs	R-HSA-5689901	2.086701e-01	0.681
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.485390e-01	0.828
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.762101e-01	0.754
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.798980e-01	0.553
Platelet degranulation	R-HSA-114608	2.391027e-01	0.621
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.762101e-01	0.754
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	2.179824e-01	0.662
G-protein mediated events	R-HSA-112040	2.568960e-01	0.590
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.857764e-01	0.544
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.598110e-01	0.585
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.798980e-01	0.553
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.317486e-01	0.635
G alpha (12/13) signalling events	R-HSA-416482	2.655149e-01	0.576
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.523902e-01	0.817
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.711253e-01	0.767
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.523734e-01	0.598
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.937055e-01	0.713
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.317486e-01	0.635
Signaling by PDGF	R-HSA-186797	2.601685e-01	0.585
Interleukin-6 signaling	R-HSA-1059683	1.845227e-01	0.734
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.468871e-01	0.608
Extra-nuclear estrogen signaling	R-HSA-9009391	1.429238e-01	0.845
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.553113e-01	0.593
Translation	R-HSA-72766	2.074007e-01	0.683
RNA Polymerase II Transcription	R-HSA-73857	1.516973e-01	0.819
Neurofascin interactions	R-HSA-447043	2.134744e-01	0.671
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.808542e-01	0.743
Disorders of Developmental Biology	R-HSA-9675151	1.705002e-01	0.768
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.705002e-01	0.768
Evasion by RSV of host interferon responses	R-HSA-9833109	2.115367e-01	0.675
Signaling by FGFR1	R-HSA-5654736	1.675551e-01	0.776
Signaling by FGFR1 in disease	R-HSA-5655302	1.636402e-01	0.786
HDMs demethylate histones	R-HSA-3214842	1.865515e-01	0.729
C-type lectin receptors (CLRs)	R-HSA-5621481	2.400136e-01	0.620
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.711253e-01	0.767
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.655021e-01	0.781
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.573583e-01	0.803
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.523734e-01	0.598
RUNX3 regulates p14-ARF	R-HSA-8951936	1.558044e-01	0.807
Platelet Adhesion to exposed collagen	R-HSA-75892	1.845227e-01	0.734
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.811356e-01	0.742
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.692318e-01	0.772
Protein hydroxylation	R-HSA-9629569	2.818125e-01	0.550
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.885553e-01	0.725
Rap1 signalling	R-HSA-392517	2.523734e-01	0.598
Netrin-1 signaling	R-HSA-373752	2.139137e-01	0.670
Activation of ATR in response to replication stress	R-HSA-176187	1.573583e-01	0.803
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.549046e-01	0.594
STAT6-mediated induction of chemokines	R-HSA-3249367	2.209804e-01	0.656
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.209804e-01	0.656
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.645423e-01	0.784
Cellular response to mitochondrial stress	R-HSA-9840373	1.645423e-01	0.784
Unwinding of DNA	R-HSA-176974	1.645423e-01	0.784
MTF1 activates gene expression	R-HSA-5660489	2.857764e-01	0.544
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.857764e-01	0.544
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.992845e-01	0.701
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.740924e-01	0.562
Synaptic adhesion-like molecules	R-HSA-8849932	2.238630e-01	0.650
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.937055e-01	0.713
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.756787e-01	0.560
Signaling by NOTCH3	R-HSA-9012852	1.540199e-01	0.812
Ion homeostasis	R-HSA-5578775	1.675551e-01	0.776
Signaling by ERBB4	R-HSA-1236394	2.071943e-01	0.684
Response of Mtb to phagocytosis	R-HSA-9637690	1.964666e-01	0.707
Tie2 Signaling	R-HSA-210993	2.238630e-01	0.650
Amyloid fiber formation	R-HSA-977225	2.328856e-01	0.633
Signaling by KIT in disease	R-HSA-9669938	2.289562e-01	0.640
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.553113e-01	0.593
Uptake and function of diphtheria toxin	R-HSA-5336415	2.598110e-01	0.585
Inositol phosphate metabolism	R-HSA-1483249	1.599845e-01	0.796
ABC transporter disorders	R-HSA-5619084	1.923780e-01	0.716
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.573583e-01	0.803
ChREBP activates metabolic gene expression	R-HSA-163765	2.359762e-01	0.627
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.740924e-01	0.562
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.573583e-01	0.803
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.947333e-01	0.711
Unfolded Protein Response (UPR)	R-HSA-381119	1.691778e-01	0.772
Glycogen synthesis	R-HSA-3322077	2.818125e-01	0.550
XBP1(S) activates chaperone genes	R-HSA-381038	2.439551e-01	0.613
Selenoamino acid metabolism	R-HSA-2408522	2.675652e-01	0.573
IRE1alpha activates chaperones	R-HSA-381070	2.544554e-01	0.594
Interleukin-37 signaling	R-HSA-9008059	1.908667e-01	0.719
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.675551e-01	0.776
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.916857e-01	0.535
Protein-protein interactions at synapses	R-HSA-6794362	2.918996e-01	0.535
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.946124e-01	0.531
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.973353e-01	0.527
Diseases of Telomere Maintenance	R-HSA-9673013	2.973353e-01	0.527
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.973353e-01	0.527
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.973353e-01	0.527
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.973353e-01	0.527
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.973353e-01	0.527
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.973353e-01	0.527
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.973353e-01	0.527
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.973353e-01	0.527
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.973353e-01	0.527
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	2.973353e-01	0.527
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.973353e-01	0.527
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.973353e-01	0.527
Hereditary fructose intolerance	R-HSA-5657560	2.973353e-01	0.527
TICAM1 deficiency - HSE	R-HSA-5602566	2.973353e-01	0.527
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.973353e-01	0.527
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	R-HSA-5619110	2.973353e-01	0.527
Activation and oligomerization of BAK protein	R-HSA-111452	2.973353e-01	0.527
Activation, translocation and oligomerization of BAX	R-HSA-114294	2.973353e-01	0.527
Inhibition of PKR	R-HSA-169131	2.973353e-01	0.527
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.976632e-01	0.526
Plasma lipoprotein clearance	R-HSA-8964043	2.976632e-01	0.526
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.016881e-01	0.520
NOD1/2 Signaling Pathway	R-HSA-168638	3.016881e-01	0.520
Activation of the pre-replicative complex	R-HSA-68962	3.055386e-01	0.515
Downstream signaling of activated FGFR4	R-HSA-5654716	3.055386e-01	0.515
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.072706e-01	0.512
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.072706e-01	0.512
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	3.072706e-01	0.512
ROBO receptors bind AKAP5	R-HSA-9010642	3.072706e-01	0.512
Co-stimulation by ICOS	R-HSA-9927354	3.072706e-01	0.512
Sodium/Proton exchangers	R-HSA-425986	3.072706e-01	0.512
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.090561e-01	0.510
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.094561e-01	0.509
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.119579e-01	0.506
ERK/MAPK targets	R-HSA-198753	3.119579e-01	0.506
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.119579e-01	0.506
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.119579e-01	0.506
MET activates RAS signaling	R-HSA-8851805	3.131258e-01	0.504
Polymerase switching	R-HSA-69091	3.131258e-01	0.504
Leading Strand Synthesis	R-HSA-69109	3.131258e-01	0.504
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.131258e-01	0.504
Disorders of Nervous System Development	R-HSA-9697154	3.131258e-01	0.504
Pervasive developmental disorders	R-HSA-9005895	3.131258e-01	0.504
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.131258e-01	0.504
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	3.131258e-01	0.504
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	3.131258e-01	0.504
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	3.131258e-01	0.504
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.137016e-01	0.503
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	3.137016e-01	0.503
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	3.137016e-01	0.503
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	3.137016e-01	0.503
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.137016e-01	0.503
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.200773e-01	0.495
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.200773e-01	0.495
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.255970e-01	0.487
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.312306e-01	0.480
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.369292e-01	0.472
Suppression of phagosomal maturation	R-HSA-9637687	3.369292e-01	0.472
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.417551e-01	0.466
Mitochondrial calcium ion transport	R-HSA-8949215	3.425896e-01	0.465
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.428343e-01	0.465
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.473776e-01	0.459
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.473776e-01	0.459
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.473776e-01	0.459
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	3.479883e-01	0.458
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.479883e-01	0.458
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.479883e-01	0.458
Glycogen storage diseases	R-HSA-3229121	3.479883e-01	0.458
RUNX2 regulates bone development	R-HSA-8941326	3.498469e-01	0.456
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.499981e-01	0.456
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	3.499981e-01	0.456
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.499981e-01	0.456
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.499981e-01	0.456
Co-inhibition by BTLA	R-HSA-9927353	3.499981e-01	0.456
PTK6 Activates STAT3	R-HSA-8849474	3.499981e-01	0.456
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.526010e-01	0.453
Membrane binding and targetting of GAG proteins	R-HSA-174490	3.526010e-01	0.453
Lipophagy	R-HSA-9613354	3.550014e-01	0.450
WNT mediated activation of DVL	R-HSA-201688	3.550014e-01	0.450
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.550014e-01	0.450
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.550014e-01	0.450
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.550014e-01	0.450
DNA strand elongation	R-HSA-69190	3.572554e-01	0.447
Signaling by WNT in cancer	R-HSA-4791275	3.572554e-01	0.447
mRNA Splicing - Minor Pathway	R-HSA-72165	3.579155e-01	0.446
Diseases of DNA repair	R-HSA-9675135	3.579155e-01	0.446
Cristae formation	R-HSA-8949613	3.651158e-01	0.438
Regulated Necrosis	R-HSA-5218859	3.669827e-01	0.435
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.679675e-01	0.434
Sensory processing of sound	R-HSA-9659379	3.695763e-01	0.432
Neurexins and neuroligins	R-HSA-6794361	3.713026e-01	0.430
Signaling by FGFR	R-HSA-190236	3.726631e-01	0.429
FGFR2 alternative splicing	R-HSA-6803529	3.734944e-01	0.428
Notch-HLH transcription pathway	R-HSA-350054	3.734944e-01	0.428
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.800486e-01	0.420
Opioid Signalling	R-HSA-111885	3.807004e-01	0.419
Circadian clock	R-HSA-9909396	3.810505e-01	0.419
FGFR1 mutant receptor activation	R-HSA-1839124	3.834861e-01	0.416
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.869476e-01	0.412
FOXO-mediated transcription	R-HSA-9614085	3.881997e-01	0.411
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	3.920845e-01	0.407
CRMPs in Sema3A signaling	R-HSA-399956	3.920845e-01	0.407
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.920845e-01	0.407
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	3.920845e-01	0.407
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.934575e-01	0.405
Toll-like Receptor Cascades	R-HSA-168898	3.954741e-01	0.403
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.958853e-01	0.402
MAPK3 (ERK1) activation	R-HSA-110056	4.022809e-01	0.395
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.022809e-01	0.395
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.022809e-01	0.395
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	4.022809e-01	0.395
Signaling by Leptin	R-HSA-2586552	4.022809e-01	0.395
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.068251e-01	0.391
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	4.097996e-01	0.387
Interactions of Tat with host cellular proteins	R-HSA-176034	4.110003e-01	0.386
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	4.110003e-01	0.386
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	4.110003e-01	0.386
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	4.110003e-01	0.386
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	4.110003e-01	0.386
TRAF3 deficiency - HSE	R-HSA-5602571	4.110003e-01	0.386
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	R-HSA-5619048	4.110003e-01	0.386
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	4.110003e-01	0.386
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	4.110003e-01	0.386
PTEN Loss of Function in Cancer	R-HSA-5674404	4.110003e-01	0.386
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	4.110003e-01	0.386
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	4.110003e-01	0.386
Defective MMADHC causes MMAHCD	R-HSA-3359473	4.110003e-01	0.386
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	4.110003e-01	0.386
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	4.110003e-01	0.386
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	4.110003e-01	0.386
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	4.110003e-01	0.386
Transport of connexins along the secretory pathway	R-HSA-190827	4.110003e-01	0.386
Oligomerization of connexins into connexons	R-HSA-190704	4.110003e-01	0.386
Inhibition of membrane repair	R-HSA-9635644	4.110003e-01	0.386
Signaling by TGFB family members	R-HSA-9006936	4.110910e-01	0.386
Signalling to p38 via RIT and RIN	R-HSA-187706	4.121365e-01	0.385
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	4.121365e-01	0.385
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.121365e-01	0.385
Noncanonical activation of NOTCH3	R-HSA-9017802	4.121365e-01	0.385
IkBA variant leads to EDA-ID	R-HSA-5603029	4.121365e-01	0.385
Phosphorylation of Emi1	R-HSA-176417	4.121365e-01	0.385
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.121365e-01	0.385
CLEC7A/inflammasome pathway	R-HSA-5660668	4.121365e-01	0.385
Proton/oligopeptide cotransporters	R-HSA-427975	4.121365e-01	0.385
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	4.121365e-01	0.385
E2F mediated regulation of DNA replication	R-HSA-113510	4.168586e-01	0.380
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.168586e-01	0.380
The NLRP3 inflammasome	R-HSA-844456	4.168586e-01	0.380
Platelet calcium homeostasis	R-HSA-418360	4.218030e-01	0.375
Generic Transcription Pathway	R-HSA-212436	4.221004e-01	0.375
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.229454e-01	0.374
Metabolism of polyamines	R-HSA-351202	4.236929e-01	0.373
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.311902e-01	0.365
SHC1 events in EGFR signaling	R-HSA-180336	4.311902e-01	0.365
ERBB2 Regulates Cell Motility	R-HSA-6785631	4.311902e-01	0.365
Interleukin-6 family signaling	R-HSA-6783589	4.353218e-01	0.361
RMTs methylate histone arginines	R-HSA-3214858	4.355666e-01	0.361
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	4.360776e-01	0.360
Signaling by NOTCH2	R-HSA-1980145	4.360776e-01	0.360
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	4.394931e-01	0.357
IRS-related events triggered by IGF1R	R-HSA-2428928	4.439056e-01	0.353
Bicarbonate transporters	R-HSA-425381	4.485148e-01	0.348
Ionotropic activity of kainate receptors	R-HSA-451306	4.485148e-01	0.348
Suppression of apoptosis	R-HSA-9635465	4.485148e-01	0.348
Interleukin-2 signaling	R-HSA-9020558	4.485148e-01	0.348
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.500093e-01	0.347
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.500093e-01	0.347
PERK regulates gene expression	R-HSA-381042	4.622081e-01	0.335
Downstream signaling of activated FGFR2	R-HSA-5654696	4.622081e-01	0.335
Downstream signaling of activated FGFR1	R-HSA-5654687	4.622081e-01	0.335
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.640687e-01	0.333
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.658776e-01	0.332
TGFBR3 expression	R-HSA-9839394	4.658776e-01	0.332
Interleukin-7 signaling	R-HSA-1266695	4.658776e-01	0.332
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.695826e-01	0.328
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.695826e-01	0.328
Regulation of BACH1 activity	R-HSA-9708530	4.695826e-01	0.328
VLDL assembly	R-HSA-8866423	4.711856e-01	0.327
Erythropoietin activates STAT5	R-HSA-9027283	4.711856e-01	0.327
Autointegration results in viral DNA circles	R-HSA-177539	4.711856e-01	0.327
Defective CHST3 causes SEDCJD	R-HSA-3595172	4.711856e-01	0.327
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	4.711856e-01	0.327
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	4.711856e-01	0.327
CREB phosphorylation	R-HSA-199920	4.711856e-01	0.327
Integration of viral DNA into host genomic DNA	R-HSA-175567	4.711856e-01	0.327
Budding and maturation of HIV virion	R-HSA-162588	4.779434e-01	0.321
Signaling by FGFR in disease	R-HSA-1226099	4.790588e-01	0.320
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.844331e-01	0.315
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.844331e-01	0.315
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	4.844331e-01	0.315
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.880862e-01	0.312
RNA Polymerase III Transcription	R-HSA-74158	4.880862e-01	0.312
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.932306e-01	0.307
ERKs are inactivated	R-HSA-202670	4.932306e-01	0.307
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.932306e-01	0.307
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.932306e-01	0.307
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.959765e-01	0.305
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.959765e-01	0.305
Leishmania phagocytosis	R-HSA-9664417	5.026594e-01	0.299
FCGR3A-mediated phagocytosis	R-HSA-9664422	5.026594e-01	0.299
Parasite infection	R-HSA-9664407	5.026594e-01	0.299
Insulin receptor signalling cascade	R-HSA-74751	5.040482e-01	0.298
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	5.062839e-01	0.296
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	5.062839e-01	0.296
Defective ALG9 causes CDG-1l	R-HSA-4720454	5.062839e-01	0.296
Signalling to ERK5	R-HSA-198765	5.062839e-01	0.296
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	5.062839e-01	0.296
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	5.062839e-01	0.296
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	5.062839e-01	0.296
Signaling by RAS GAP mutants	R-HSA-9753510	5.062839e-01	0.296
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	5.062839e-01	0.296
The AIM2 inflammasome	R-HSA-844615	5.062839e-01	0.296
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	5.062839e-01	0.296
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	5.062839e-01	0.296
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	5.062839e-01	0.296
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	5.062839e-01	0.296
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.069778e-01	0.295
HCMV Late Events	R-HSA-9610379	5.152584e-01	0.288
Attachment and Entry	R-HSA-9694614	5.171986e-01	0.286
Assembly Of The HIV Virion	R-HSA-175474	5.171986e-01	0.286
Regulation of beta-cell development	R-HSA-186712	5.179370e-01	0.286
Deadenylation-dependent mRNA decay	R-HSA-429914	5.179370e-01	0.286
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.254758e-01	0.279
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.254758e-01	0.279
Signaling by FGFR3 in disease	R-HSA-5655332	5.254758e-01	0.279
Activation of TRKA receptors	R-HSA-187015	5.265189e-01	0.279
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.265189e-01	0.279
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	5.265189e-01	0.279
LDL remodeling	R-HSA-8964041	5.265189e-01	0.279
VLDL clearance	R-HSA-8964046	5.265189e-01	0.279
Defective CHSY1 causes TPBS	R-HSA-3595177	5.265189e-01	0.279
Activated NTRK2 signals through CDK5	R-HSA-9032845	5.265189e-01	0.279
PTK6 Expression	R-HSA-8849473	5.265189e-01	0.279
SLC-mediated transport of oligopeptides	R-HSA-9959399	5.265189e-01	0.279
Cation-coupled Chloride cotransporters	R-HSA-426117	5.265189e-01	0.279
GPER1 signaling	R-HSA-9634597	5.271510e-01	0.278
Gluconeogenesis	R-HSA-70263	5.271510e-01	0.278
Nuclear RNA decay	R-HSA-9930044	5.325190e-01	0.274
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.325190e-01	0.274
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.360670e-01	0.271
GRB2 events in EGFR signaling	R-HSA-179812	5.360670e-01	0.271
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	5.360670e-01	0.271
Defective EXT2 causes exostoses 2	R-HSA-3656237	5.360670e-01	0.271
Regulation of IFNG signaling	R-HSA-877312	5.360670e-01	0.271
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.360670e-01	0.271
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.360670e-01	0.271
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.360670e-01	0.271
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.360670e-01	0.271
Interleukin-15 signaling	R-HSA-8983432	5.360670e-01	0.271
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.383031e-01	0.269
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.383031e-01	0.269
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.383031e-01	0.269
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.383031e-01	0.269
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.383031e-01	0.269
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.431418e-01	0.265
Regulation of NPAS4 gene expression	R-HSA-9768759	5.431418e-01	0.265
Regulation of FZD by ubiquitination	R-HSA-4641263	5.431418e-01	0.265
Uptake and function of anthrax toxins	R-HSA-5210891	5.431418e-01	0.265
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.490525e-01	0.260
RAF-independent MAPK1/3 activation	R-HSA-112409	5.490525e-01	0.260
LDL clearance	R-HSA-8964038	5.490525e-01	0.260
HIV elongation arrest and recovery	R-HSA-167287	5.542505e-01	0.256
Pausing and recovery of HIV elongation	R-HSA-167290	5.542505e-01	0.256
Inflammasomes	R-HSA-622312	5.542505e-01	0.256
Phase 0 - rapid depolarisation	R-HSA-5576892	5.542505e-01	0.256
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.589517e-01	0.253
Resolution of D-Loop Structures	R-HSA-5693537	5.589517e-01	0.253
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.632792e-01	0.249
PI3K Cascade	R-HSA-109704	5.711019e-01	0.243
Developmental Cell Lineages	R-HSA-9734767	5.721450e-01	0.242
Detoxification of Reactive Oxygen Species	R-HSA-3299685	5.746898e-01	0.241
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.767612e-01	0.239
Formation of axial mesoderm	R-HSA-9796292	5.767612e-01	0.239
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.767612e-01	0.239
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	5.777935e-01	0.238
EGFR interacts with phospholipase C-gamma	R-HSA-212718	5.777935e-01	0.238
Regulation of NPAS4 mRNA translation	R-HSA-9768778	5.777935e-01	0.238
TGFBR3 PTM regulation	R-HSA-9839383	5.777935e-01	0.238
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.777935e-01	0.238
Activated NTRK2 signals through FYN	R-HSA-9032500	5.777935e-01	0.238
PKA activation	R-HSA-163615	5.778882e-01	0.238
Mitochondrial protein import	R-HSA-1268020	5.781044e-01	0.238
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	5.798562e-01	0.237
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.798562e-01	0.237
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.798562e-01	0.237
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.798562e-01	0.237
Growth hormone receptor signaling	R-HSA-982772	5.798562e-01	0.237
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.801006e-01	0.236
mRNA Capping	R-HSA-72086	5.821934e-01	0.235
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.821934e-01	0.235
Disorders of transmembrane transporters	R-HSA-5619115	5.844962e-01	0.233
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.846955e-01	0.233
FasL/ CD95L signaling	R-HSA-75157	5.861579e-01	0.232
The NLRP1 inflammasome	R-HSA-844455	5.861579e-01	0.232
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.861579e-01	0.232
Defective MMACHC causes MAHCC	R-HSA-3359474	5.861579e-01	0.232
Signalling to STAT3	R-HSA-198745	5.861579e-01	0.232
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	5.861579e-01	0.232
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	5.861579e-01	0.232
Invadopodia formation	R-HSA-8941237	5.861579e-01	0.232
Inhibition of nitric oxide production	R-HSA-9636249	5.861579e-01	0.232
MET activates STAT3	R-HSA-8875791	5.861579e-01	0.232
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.861579e-01	0.232
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	5.861579e-01	0.232
Activation of BIM and translocation to mitochondria	R-HSA-111446	5.861579e-01	0.232
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.861579e-01	0.232
HIV Transcription Elongation	R-HSA-167169	5.872638e-01	0.231
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.872638e-01	0.231
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.872638e-01	0.231
Nuclear signaling by ERBB4	R-HSA-1251985	5.872638e-01	0.231
IRS-mediated signalling	R-HSA-112399	5.949561e-01	0.226
Cell surface interactions at the vascular wall	R-HSA-202733	5.999383e-01	0.222
Iron uptake and transport	R-HSA-917937	6.023354e-01	0.220
FCERI mediated MAPK activation	R-HSA-2871796	6.036750e-01	0.219
Complex III assembly	R-HSA-9865881	6.094978e-01	0.215
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.094978e-01	0.215
PI-3K cascade:FGFR3	R-HSA-5654710	6.110747e-01	0.214
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.110747e-01	0.214
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.110747e-01	0.214
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.110747e-01	0.214
Specification of the neural plate border	R-HSA-9834899	6.110747e-01	0.214
Other interleukin signaling	R-HSA-449836	6.110747e-01	0.214
Regulation of pyruvate metabolism	R-HSA-9861718	6.118148e-01	0.213
Signaling by TGFBR3	R-HSA-9839373	6.118148e-01	0.213
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.132266e-01	0.212
Removal of the Flap Intermediate	R-HSA-69166	6.151363e-01	0.211
Retrograde neurotrophin signalling	R-HSA-177504	6.151363e-01	0.211
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.151363e-01	0.211
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.151363e-01	0.211
Ion transport by P-type ATPases	R-HSA-936837	6.164009e-01	0.210
Signaling by NOTCH1	R-HSA-1980143	6.198212e-01	0.208
mRNA Editing	R-HSA-75072	6.248743e-01	0.204
p75NTR regulates axonogenesis	R-HSA-193697	6.248743e-01	0.204
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.248743e-01	0.204
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.248743e-01	0.204
Regulation of CDH11 gene transcription	R-HSA-9762293	6.248743e-01	0.204
Regulated proteolysis of p75NTR	R-HSA-193692	6.248743e-01	0.204
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.248743e-01	0.204
Respiratory syncytial virus genome replication	R-HSA-9834752	6.248743e-01	0.204
Intra-Golgi traffic	R-HSA-6811438	6.332292e-01	0.198
Extension of Telomeres	R-HSA-180786	6.340948e-01	0.198
Amino acid transport across the plasma membrane	R-HSA-352230	6.340948e-01	0.198
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	6.352399e-01	0.197
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.406065e-01	0.193
Post-translational protein phosphorylation	R-HSA-8957275	6.419290e-01	0.193
PI-3K cascade:FGFR4	R-HSA-5654720	6.425991e-01	0.192
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.425991e-01	0.192
Formation of definitive endoderm	R-HSA-9823730	6.425991e-01	0.192
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.425991e-01	0.192
Processive synthesis on the lagging strand	R-HSA-69183	6.510879e-01	0.186
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.510879e-01	0.186
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.510879e-01	0.186
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.531135e-01	0.185
Activated NTRK2 signals through PLCG1	R-HSA-9026527	6.531135e-01	0.185
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	6.531135e-01	0.185
Defective LFNG causes SCDO3	R-HSA-5083630	6.531135e-01	0.185
Signaling by MAP2K mutants	R-HSA-9652169	6.531135e-01	0.185
Defective MAT1A causes MATD	R-HSA-5579024	6.531135e-01	0.185
Transcriptional activation of p53 responsive genes	R-HSA-69560	6.531135e-01	0.185
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	6.531135e-01	0.185
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	6.531135e-01	0.185
TNFR1-mediated ceramide production	R-HSA-5626978	6.531135e-01	0.185
NADE modulates death signalling	R-HSA-205025	6.531135e-01	0.185
Dopamine receptors	R-HSA-390651	6.531135e-01	0.185
Interleukin-38 signaling	R-HSA-9007892	6.531135e-01	0.185
Nuclear Receptor transcription pathway	R-HSA-383280	6.536436e-01	0.185
NGF-stimulated transcription	R-HSA-9031628	6.538735e-01	0.185
MET activates PTK2 signaling	R-HSA-8874081	6.649677e-01	0.177
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.649677e-01	0.177
Binding and entry of HIV virion	R-HSA-173107	6.677761e-01	0.175
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.677761e-01	0.175
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.677761e-01	0.175
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.677761e-01	0.175
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.677761e-01	0.175
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.692370e-01	0.174
SLC-mediated transport of amino acids	R-HSA-9958863	6.704607e-01	0.174
SHC-mediated cascade:FGFR3	R-HSA-5654704	6.723947e-01	0.172
Lagging Strand Synthesis	R-HSA-69186	6.723947e-01	0.172
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.723947e-01	0.172
Zygotic genome activation (ZGA)	R-HSA-9819196	6.723947e-01	0.172
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	6.738926e-01	0.171
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.794804e-01	0.168
Activation of SMO	R-HSA-5635838	6.845719e-01	0.165
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.845719e-01	0.165
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.845719e-01	0.165
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.845719e-01	0.165
Platelet homeostasis	R-HSA-418346	6.853680e-01	0.164
ER Quality Control Compartment (ERQC)	R-HSA-901032	6.906883e-01	0.161
Signaling by FGFR2 in disease	R-HSA-5655253	6.932013e-01	0.159
Azathioprine ADME	R-HSA-9748787	6.932013e-01	0.159
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.937932e-01	0.159
PI Metabolism	R-HSA-1483255	6.988976e-01	0.156
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.002996e-01	0.155
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.004264e-01	0.155
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.004264e-01	0.155
Post-translational protein modification	R-HSA-597592	7.055191e-01	0.151
Chylomicron assembly	R-HSA-8963888	7.066188e-01	0.151
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.066188e-01	0.151
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.066188e-01	0.151
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	7.066188e-01	0.151
RHOBTB3 ATPase cycle	R-HSA-9706019	7.066188e-01	0.151
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.066188e-01	0.151
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.066188e-01	0.151
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	7.092396e-01	0.149
SMAC (DIABLO) binds to IAPs	R-HSA-111463	7.092396e-01	0.149
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	7.092396e-01	0.149
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	7.092396e-01	0.149
G2 Phase	R-HSA-68911	7.092396e-01	0.149
Defective F9 activation	R-HSA-9673221	7.092396e-01	0.149
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	7.092396e-01	0.149
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	7.092396e-01	0.149
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	7.092396e-01	0.149
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	7.092396e-01	0.149
Activation of AKT2	R-HSA-165158	7.092396e-01	0.149
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	7.092396e-01	0.149
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	7.092396e-01	0.149
NTRK2 activates RAC1	R-HSA-9032759	7.092396e-01	0.149
Suppression of autophagy	R-HSA-9636569	7.092396e-01	0.149
Pyrophosphate hydrolysis	R-HSA-71737	7.092396e-01	0.149
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	7.092396e-01	0.149
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	7.092396e-01	0.149
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	7.092396e-01	0.149
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	7.092396e-01	0.149
Assembly of Viral Components at the Budding Site	R-HSA-168316	7.092396e-01	0.149
Telomere Extension By Telomerase	R-HSA-171319	7.150268e-01	0.146
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.150268e-01	0.146
Formation of the Early Elongation Complex	R-HSA-113418	7.150268e-01	0.146
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.150268e-01	0.146
G beta:gamma signalling through CDC42	R-HSA-8964616	7.155935e-01	0.145
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.155935e-01	0.145
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.155935e-01	0.145
Acetylcholine regulates insulin secretion	R-HSA-399997	7.155935e-01	0.145
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.155935e-01	0.145
Innate Immune System	R-HSA-168249	7.194353e-01	0.143
Glycogen metabolism	R-HSA-8982491	7.213607e-01	0.142
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.256569e-01	0.139
PI-3K cascade:FGFR1	R-HSA-5654689	7.266857e-01	0.139
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.266857e-01	0.139
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.266857e-01	0.139
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.266857e-01	0.139
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	7.284535e-01	0.138
Calnexin/calreticulin cycle	R-HSA-901042	7.284535e-01	0.138
NPAS4 regulates expression of target genes	R-HSA-9768919	7.284535e-01	0.138
DS-GAG biosynthesis	R-HSA-2022923	7.415925e-01	0.130
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.415925e-01	0.130
Endosomal/Vacuolar pathway	R-HSA-1236977	7.415925e-01	0.130
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.415925e-01	0.130
Sodium/Calcium exchangers	R-HSA-425561	7.415925e-01	0.130
Peroxisomal protein import	R-HSA-9033241	7.421194e-01	0.130
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.441966e-01	0.128
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.441966e-01	0.128
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.441966e-01	0.128
Regulation of PTEN mRNA translation	R-HSA-8943723	7.511869e-01	0.124
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.523278e-01	0.124
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.554383e-01	0.122
NGF-independant TRKA activation	R-HSA-187024	7.562872e-01	0.121
Plus-strand DNA synthesis	R-HSA-164525	7.562872e-01	0.121
Nef Mediated CD8 Down-regulation	R-HSA-182218	7.562872e-01	0.121
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.562872e-01	0.121
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.562872e-01	0.121
Defective CSF2RB causes SMDP5	R-HSA-5688849	7.562872e-01	0.121
Defective CSF2RA causes SMDP4	R-HSA-5688890	7.562872e-01	0.121
Signaling by MAPK mutants	R-HSA-9652817	7.562872e-01	0.121
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	7.562872e-01	0.121
Signaling by MST1	R-HSA-8852405	7.562872e-01	0.121
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	7.562872e-01	0.121
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	7.562872e-01	0.121
Release of apoptotic factors from the mitochondria	R-HSA-111457	7.562872e-01	0.121
PKB-mediated events	R-HSA-109703	7.562872e-01	0.121
PDE3B signalling	R-HSA-165160	7.562872e-01	0.121
Cam-PDE 1 activation	R-HSA-111957	7.562872e-01	0.121
Synthesis of PS	R-HSA-1483101	7.562872e-01	0.121
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	7.562872e-01	0.121
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	7.562872e-01	0.121
Sodium-coupled phosphate cotransporters	R-HSA-427652	7.562872e-01	0.121
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	7.562872e-01	0.121
VEGF ligand-receptor interactions	R-HSA-194313	7.562872e-01	0.121
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	7.562872e-01	0.121
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.562872e-01	0.121
RAB geranylgeranylation	R-HSA-8873719	7.579017e-01	0.120
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.593492e-01	0.120
Gastrulation	R-HSA-9758941	7.642780e-01	0.117
Lysosome Vesicle Biogenesis	R-HSA-432720	7.682397e-01	0.115
Metal ion SLC transporters	R-HSA-425410	7.692335e-01	0.114
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.704555e-01	0.113
Mismatch Repair	R-HSA-5358508	7.704555e-01	0.113
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.704555e-01	0.113
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.704555e-01	0.113
PKA activation in glucagon signalling	R-HSA-164378	7.704555e-01	0.113
Repression of WNT target genes	R-HSA-4641265	7.729322e-01	0.112
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.729322e-01	0.112
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.729322e-01	0.112
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.739632e-01	0.111
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.739632e-01	0.111
Neddylation	R-HSA-8951664	7.780814e-01	0.109
G alpha (z) signalling events	R-HSA-418597	7.785814e-01	0.109
Molecules associated with elastic fibres	R-HSA-2129379	7.797407e-01	0.108
Transmission across Chemical Synapses	R-HSA-112315	7.804100e-01	0.108
Transcription of the HIV genome	R-HSA-167172	7.823621e-01	0.107
Germ layer formation at gastrulation	R-HSA-9754189	7.944668e-01	0.100
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.944668e-01	0.100
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.944668e-01	0.100
PI-3K cascade:FGFR2	R-HSA-5654695	7.950627e-01	0.100
Laminin interactions	R-HSA-3000157	7.950627e-01	0.100
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.950627e-01	0.100
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.957243e-01	0.099
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.957243e-01	0.099
Chylomicron clearance	R-HSA-8964026	7.957243e-01	0.099
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.957243e-01	0.099
Uncoating of the HIV Virion	R-HSA-162585	7.957243e-01	0.099
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.957243e-01	0.099
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.957243e-01	0.099
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.957243e-01	0.099
MET Receptor Activation	R-HSA-6806942	7.957243e-01	0.099
Lactose synthesis	R-HSA-5653890	7.957243e-01	0.099
Abacavir transmembrane transport	R-HSA-2161517	7.957243e-01	0.099
Regulation of NFE2L2 gene expression	R-HSA-9818749	7.957243e-01	0.099
NADPH regeneration	R-HSA-389542	7.957243e-01	0.099
HDL clearance	R-HSA-8964011	7.957243e-01	0.099
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.986059e-01	0.098
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.008982e-01	0.096
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.008982e-01	0.096
Processing of SMDT1	R-HSA-8949664	8.008982e-01	0.096
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.008982e-01	0.096
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.008982e-01	0.096
Maturation of nucleoprotein	R-HSA-9683610	8.008982e-01	0.096
Protein localization	R-HSA-9609507	8.015287e-01	0.096
RSV-host interactions	R-HSA-9833110	8.085278e-01	0.092
COPII-mediated vesicle transport	R-HSA-204005	8.085994e-01	0.092
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.145457e-01	0.089
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.145457e-01	0.089
TRP channels	R-HSA-3295583	8.145457e-01	0.089
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.163432e-01	0.088
VxPx cargo-targeting to cilium	R-HSA-5620916	8.163432e-01	0.088
Signaling by NODAL	R-HSA-1181150	8.163432e-01	0.088
Leishmania infection	R-HSA-9658195	8.190477e-01	0.087
Parasitic Infection Pathways	R-HSA-9824443	8.190477e-01	0.087
RAS processing	R-HSA-9648002	8.195186e-01	0.086
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.237633e-01	0.084
cGMP effects	R-HSA-418457	8.257614e-01	0.083
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.257614e-01	0.083
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.257614e-01	0.083
Physiological factors	R-HSA-5578768	8.257614e-01	0.083
Malate-aspartate shuttle	R-HSA-9856872	8.257614e-01	0.083
Acyl chain remodeling of CL	R-HSA-1482798	8.257614e-01	0.083
Zinc transporters	R-HSA-435354	8.257614e-01	0.083
Infectious disease	R-HSA-5663205	8.277332e-01	0.082
Uptake and actions of bacterial toxins	R-HSA-5339562	8.284768e-01	0.082
NOSTRIN mediated eNOS trafficking	R-HSA-203641	8.287816e-01	0.082
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	8.287816e-01	0.082
IFNG signaling activates MAPKs	R-HSA-9732724	8.287816e-01	0.082
TRIF-mediated programmed cell death	R-HSA-2562578	8.287816e-01	0.082
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	8.287816e-01	0.082
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	8.287816e-01	0.082
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	8.287816e-01	0.082
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	8.287816e-01	0.082
Nef Mediated CD4 Down-regulation	R-HSA-167590	8.287816e-01	0.082
Synthesis of PIPs in the nucleus	R-HSA-8847453	8.287816e-01	0.082
Ca2+ activated K+ channels	R-HSA-1296052	8.287816e-01	0.082
Netrin mediated repulsion signals	R-HSA-418886	8.287816e-01	0.082
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	8.287816e-01	0.082
Displacement of DNA glycosylase by APEX1	R-HSA-110357	8.287816e-01	0.082
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	8.287816e-01	0.082
FCERI mediated NF-kB activation	R-HSA-2871837	8.298826e-01	0.081
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.324815e-01	0.080
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.324815e-01	0.080
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.324815e-01	0.080
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.324815e-01	0.080
Ca2+ pathway	R-HSA-4086398	8.434456e-01	0.074
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.476032e-01	0.072
Signal amplification	R-HSA-392518	8.476032e-01	0.072
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.477936e-01	0.072
G beta:gamma signalling through BTK	R-HSA-8964315	8.477936e-01	0.072
Telomere C-strand synthesis initiation	R-HSA-174430	8.477936e-01	0.072
Protein lipoylation	R-HSA-9857492	8.477936e-01	0.072
Lysosphingolipid and LPA receptors	R-HSA-419408	8.477936e-01	0.072
Biotin transport and metabolism	R-HSA-196780	8.477936e-01	0.072
Other semaphorin interactions	R-HSA-416700	8.477936e-01	0.072
DNA Damage Reversal	R-HSA-73942	8.477936e-01	0.072
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.484106e-01	0.071
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.521549e-01	0.069
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.541899e-01	0.068
Ribavirin ADME	R-HSA-9755088	8.541899e-01	0.068
Reverse Transcription of HIV RNA	R-HSA-162589	8.564910e-01	0.067
Minus-strand DNA synthesis	R-HSA-164516	8.564910e-01	0.067
phospho-PLA2 pathway	R-HSA-111995	8.564910e-01	0.067
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.564910e-01	0.067
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.564910e-01	0.067
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	8.564910e-01	0.067
Interleukin-9 signaling	R-HSA-8985947	8.564910e-01	0.067
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	8.564910e-01	0.067
Regulation by c-FLIP	R-HSA-3371378	8.564910e-01	0.067
Activation of RAS in B cells	R-HSA-1169092	8.564910e-01	0.067
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.564910e-01	0.067
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.564910e-01	0.067
Dimerization of procaspase-8	R-HSA-69416	8.564910e-01	0.067
SLC-mediated bile acid transport	R-HSA-9958517	8.564910e-01	0.067
Nucleotide salvage defects	R-HSA-9734207	8.564910e-01	0.067
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.564910e-01	0.067
Interleukin-23 signaling	R-HSA-9020933	8.564910e-01	0.067
Signaling by Insulin receptor	R-HSA-74752	8.579830e-01	0.067
Translation of Structural Proteins	R-HSA-9683701	8.613766e-01	0.065
SLC transporter disorders	R-HSA-5619102	8.615688e-01	0.065
Heme signaling	R-HSA-9707616	8.671375e-01	0.062
Induction of Cell-Cell Fusion	R-HSA-9733458	8.672598e-01	0.062
Attachment and Entry	R-HSA-9678110	8.672598e-01	0.062
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.672598e-01	0.062
Class I peroxisomal membrane protein import	R-HSA-9603798	8.672598e-01	0.062
Atorvastatin ADME	R-HSA-9754706	8.672598e-01	0.062
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.672598e-01	0.062
Differentiation of T cells	R-HSA-9945266	8.672598e-01	0.062
FCERI mediated Ca+2 mobilization	R-HSA-2871809	8.681140e-01	0.061
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.704215e-01	0.060
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.704215e-01	0.060
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.704215e-01	0.060
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.770710e-01	0.057
Interleukin-21 signaling	R-HSA-9020958	8.797173e-01	0.056
CASP8 activity is inhibited	R-HSA-5218900	8.797173e-01	0.056
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	8.797173e-01	0.056
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.797173e-01	0.056
Regulation of signaling by NODAL	R-HSA-1433617	8.797173e-01	0.056
MAPK1 (ERK2) activation	R-HSA-112411	8.797173e-01	0.056
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	8.797173e-01	0.056
Interleukin-1 processing	R-HSA-448706	8.797173e-01	0.056
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.797173e-01	0.056
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.797173e-01	0.056
Mitochondrial biogenesis	R-HSA-1592230	8.827019e-01	0.054
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.844133e-01	0.053
Heme assimilation	R-HSA-9927020	8.844133e-01	0.053
tRNA modification in the mitochondrion	R-HSA-6787450	8.844133e-01	0.053
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.844133e-01	0.053
Coenzyme A biosynthesis	R-HSA-196783	8.844133e-01	0.053
Passive transport by Aquaporins	R-HSA-432047	8.844133e-01	0.053
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	8.844133e-01	0.053
Response to metal ions	R-HSA-5660526	8.844133e-01	0.053
TRAF6 mediated IRF7 activation	R-HSA-933541	8.862876e-01	0.052
Stimuli-sensing channels	R-HSA-2672351	8.963908e-01	0.048
Elastic fibre formation	R-HSA-1566948	8.971586e-01	0.047
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.971586e-01	0.047
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.981564e-01	0.047
Plasma lipoprotein assembly	R-HSA-8963898	8.981564e-01	0.047
DNA replication initiation	R-HSA-68952	8.991856e-01	0.046
Interleukin-27 signaling	R-HSA-9020956	8.991856e-01	0.046
CASP4 inflammasome assembly	R-HSA-9948001	8.991856e-01	0.046
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.991856e-01	0.046
Defective factor IX causes hemophilia B	R-HSA-9668250	8.991856e-01	0.046
Sperm Motility And Taxes	R-HSA-1300642	8.991856e-01	0.046
Regulation of the apoptosome activity	R-HSA-9627069	8.991856e-01	0.046
Formation of apoptosome	R-HSA-111458	8.991856e-01	0.046
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.994928e-01	0.046
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.994928e-01	0.046
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.994928e-01	0.046
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.994928e-01	0.046
Choline catabolism	R-HSA-6798163	8.994928e-01	0.046
Specification of primordial germ cells	R-HSA-9827857	8.994928e-01	0.046
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.043728e-01	0.044
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	9.071168e-01	0.042
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.088666e-01	0.041
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.099134e-01	0.041
Acyl chain remodelling of PS	R-HSA-1482801	9.099134e-01	0.041
Formation of the nephric duct	R-HSA-9830364	9.099134e-01	0.041
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.108270e-01	0.041
Nucleotide biosynthesis	R-HSA-8956320	9.114756e-01	0.040
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.127200e-01	0.040
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.127200e-01	0.040
RNA Polymerase III Transcription Termination	R-HSA-73980	9.127200e-01	0.040
G beta:gamma signalling through PLC beta	R-HSA-418217	9.127200e-01	0.040
Apoptotic factor-mediated response	R-HSA-111471	9.127200e-01	0.040
Presynaptic function of Kainate receptors	R-HSA-500657	9.127200e-01	0.040
Nephron development	R-HSA-9831926	9.127200e-01	0.040
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.127200e-01	0.040
Pyruvate metabolism	R-HSA-70268	9.137093e-01	0.039
vRNA Synthesis	R-HSA-192814	9.155038e-01	0.038
vRNP Assembly	R-HSA-192905	9.155038e-01	0.038
Propionyl-CoA catabolism	R-HSA-71032	9.155038e-01	0.038
Synthesis of PI	R-HSA-1483226	9.155038e-01	0.038
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	9.155038e-01	0.038
SARS-CoV-2 modulates autophagy	R-HSA-9754560	9.155038e-01	0.038
Dissolution of Fibrin Clot	R-HSA-75205	9.155038e-01	0.038
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.162211e-01	0.038
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.162211e-01	0.038
Diseases of Immune System	R-HSA-5260271	9.162211e-01	0.038
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.203426e-01	0.036
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.204243e-01	0.036
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.214158e-01	0.036
Glucagon signaling in metabolic regulation	R-HSA-163359	9.214158e-01	0.036
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.214158e-01	0.036
Effects of PIP2 hydrolysis	R-HSA-114508	9.214158e-01	0.036
Maturation of nucleoprotein	R-HSA-9694631	9.242996e-01	0.034
NCAM signaling for neurite out-growth	R-HSA-375165	9.251415e-01	0.034
Scavenging by Class H Receptors	R-HSA-3000497	9.291815e-01	0.032
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.291815e-01	0.032
PI3K events in ERBB4 signaling	R-HSA-1250342	9.291815e-01	0.032
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	9.291815e-01	0.032
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	9.291815e-01	0.032
Cytochrome c-mediated apoptotic response	R-HSA-111461	9.291815e-01	0.032
Insulin processing	R-HSA-264876	9.298022e-01	0.032
eNOS activation	R-HSA-203615	9.298690e-01	0.032
Integration of energy metabolism	R-HSA-163685	9.320419e-01	0.031
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.320976e-01	0.031
HIV Transcription Initiation	R-HSA-167161	9.320976e-01	0.031
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.320976e-01	0.031
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.320976e-01	0.031
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.344182e-01	0.029
Creatine metabolism	R-HSA-71288	9.344182e-01	0.029
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.381532e-01	0.028
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.381532e-01	0.028
Pyroptosis	R-HSA-5620971	9.381532e-01	0.028
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.389799e-01	0.027
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	9.406457e-01	0.027
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	9.406457e-01	0.027
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.406457e-01	0.027
Interleukin-35 Signalling	R-HSA-8984722	9.406457e-01	0.027
Diseases associated with surfactant metabolism	R-HSA-5687613	9.406457e-01	0.027
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.406457e-01	0.027
OAS antiviral response	R-HSA-8983711	9.406457e-01	0.027
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.411802e-01	0.026
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.417750e-01	0.026
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.432453e-01	0.025
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.432453e-01	0.025
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.432453e-01	0.025
tRNA processing	R-HSA-72306	9.437292e-01	0.025
Triglyceride catabolism	R-HSA-163560	9.443529e-01	0.025
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.446144e-01	0.025
RNA Polymerase II Promoter Escape	R-HSA-73776	9.452282e-01	0.024
Neuronal System	R-HSA-112316	9.500838e-01	0.022
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	9.502547e-01	0.022
Chylomicron remodeling	R-HSA-8963901	9.502547e-01	0.022
Microbial factors inhibit CASP4 activity	R-HSA-9956593	9.502547e-01	0.022
Reversible hydration of carbon dioxide	R-HSA-1475029	9.502547e-01	0.022
Diseases of nucleotide metabolism	R-HSA-9735804	9.502547e-01	0.022
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	9.502547e-01	0.022
rRNA modification in the mitochondrion	R-HSA-6793080	9.502547e-01	0.022
Amine ligand-binding receptors	R-HSA-375280	9.508920e-01	0.022
CS-GAG biosynthesis	R-HSA-2022870	9.509338e-01	0.022
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.509338e-01	0.022
Serine metabolism	R-HSA-977347	9.509338e-01	0.022
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.509338e-01	0.022
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.521639e-01	0.021
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.554080e-01	0.020
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.560180e-01	0.020
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.560180e-01	0.020
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.560512e-01	0.020
Amino acids regulate mTORC1	R-HSA-9639288	9.570649e-01	0.019
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.576209e-01	0.019
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.576209e-01	0.019
Cargo concentration in the ER	R-HSA-5694530	9.580002e-01	0.019
Cytoprotection by HMOX1	R-HSA-9707564	9.582709e-01	0.019
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.583085e-01	0.018
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	9.583085e-01	0.018
Synthesis of IPs in the nucleus	R-HSA-1855191	9.583085e-01	0.018
Hydrolysis of LPC	R-HSA-1483115	9.583085e-01	0.018
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	9.583085e-01	0.018
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	9.583085e-01	0.018
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	9.583085e-01	0.018
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	9.583085e-01	0.018
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.583085e-01	0.018
Ciprofloxacin ADME	R-HSA-9793528	9.583085e-01	0.018
Non-canonical inflammasome activation	R-HSA-9686114	9.583085e-01	0.018
HDL assembly	R-HSA-8963896	9.583085e-01	0.018
Adipogenesis	R-HSA-9843745	9.584993e-01	0.018
Cardiac conduction	R-HSA-5576891	9.584993e-01	0.018
Aquaporin-mediated transport	R-HSA-445717	9.587190e-01	0.018
Ion channel transport	R-HSA-983712	9.602644e-01	0.018
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.606506e-01	0.017
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.606506e-01	0.017
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.610073e-01	0.017
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.628404e-01	0.016
Translation of Structural Proteins	R-HSA-9694635	9.628404e-01	0.016
HS-GAG degradation	R-HSA-2024096	9.631633e-01	0.016
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.634294e-01	0.016
Formation of the ureteric bud	R-HSA-9830674	9.634294e-01	0.016
Interleukin-20 family signaling	R-HSA-8854691	9.634294e-01	0.016
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.650588e-01	0.015
RNA Polymerase III Chain Elongation	R-HSA-73780	9.650588e-01	0.015
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.650588e-01	0.015
Signaling by Activin	R-HSA-1502540	9.650588e-01	0.015
Transport and metabolism of PAPS	R-HSA-174362	9.650588e-01	0.015
Protein repair	R-HSA-5676934	9.650588e-01	0.015
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	9.650588e-01	0.015
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.650588e-01	0.015
Interferon gamma signaling	R-HSA-877300	9.658595e-01	0.015
Cardiogenesis	R-HSA-9733709	9.677243e-01	0.014
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.684684e-01	0.014
Mitochondrial RNA degradation	R-HSA-9836573	9.684684e-01	0.014
Regulation of insulin secretion	R-HSA-422356	9.693309e-01	0.014
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.699464e-01	0.013
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.707164e-01	0.013
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.707164e-01	0.013
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.707164e-01	0.013
Fructose catabolism	R-HSA-70350	9.707164e-01	0.013
Virus Assembly and Release	R-HSA-168268	9.707164e-01	0.013
Heme degradation	R-HSA-189483	9.717478e-01	0.012
Miscellaneous transport and binding events	R-HSA-5223345	9.717478e-01	0.012
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.728347e-01	0.012
G protein gated Potassium channels	R-HSA-1296059	9.728347e-01	0.012
Activation of G protein gated Potassium channels	R-HSA-1296041	9.728347e-01	0.012
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.728347e-01	0.012
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.728347e-01	0.012
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.728347e-01	0.012
Scavenging by Class A Receptors	R-HSA-3000480	9.729339e-01	0.012
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.729339e-01	0.012
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.744575e-01	0.011
Mitochondrial protein degradation	R-HSA-9837999	9.748122e-01	0.011
Scavenging by Class B Receptors	R-HSA-3000471	9.754583e-01	0.011
Glycine degradation	R-HSA-6783984	9.754583e-01	0.011
Fibronectin matrix formation	R-HSA-1566977	9.754583e-01	0.011
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	9.754583e-01	0.011
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	9.754583e-01	0.011
Synthesis of PG	R-HSA-1483148	9.754583e-01	0.011
Galactose catabolism	R-HSA-70370	9.754583e-01	0.011
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.754583e-01	0.011
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.754583e-01	0.011
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.766140e-01	0.010
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.794325e-01	0.009
HS-GAG biosynthesis	R-HSA-2022928	9.811536e-01	0.008
FGFR2 mutant receptor activation	R-HSA-1839126	9.811536e-01	0.008
Surfactant metabolism	R-HSA-5683826	9.813719e-01	0.008
Asparagine N-linked glycosylation	R-HSA-446203	9.816262e-01	0.008
Insulin receptor recycling	R-HSA-77387	9.827051e-01	0.008
Pyrimidine salvage	R-HSA-73614	9.827051e-01	0.008
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.827633e-01	0.008
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.827633e-01	0.008
Metabolism of proteins	R-HSA-392499	9.834117e-01	0.007
Integrin cell surface interactions	R-HSA-216083	9.839144e-01	0.007
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.851416e-01	0.007
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.851416e-01	0.007
Glucagon-type ligand receptors	R-HSA-420092	9.851416e-01	0.007
ECM proteoglycans	R-HSA-3000178	9.853958e-01	0.006
Retinoid metabolism and transport	R-HSA-975634	9.853958e-01	0.006
Disease	R-HSA-1643685	9.854892e-01	0.006
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.855417e-01	0.006
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.855549e-01	0.006
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.855549e-01	0.006
Pyrimidine biosynthesis	R-HSA-500753	9.855549e-01	0.006
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.855549e-01	0.006
Diseases of hemostasis	R-HSA-9671793	9.855549e-01	0.006
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.855549e-01	0.006
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.857858e-01	0.006
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.872427e-01	0.006
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	9.872427e-01	0.006
Neurotransmitter clearance	R-HSA-112311	9.872427e-01	0.006
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.872427e-01	0.006
Synthesis of PC	R-HSA-1483191	9.872778e-01	0.006
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.878945e-01	0.005
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.878945e-01	0.005
Acyl chain remodelling of PI	R-HSA-1482922	9.878945e-01	0.005
Pregnenolone biosynthesis	R-HSA-196108	9.878945e-01	0.005
G-protein activation	R-HSA-202040	9.898553e-01	0.004
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.898553e-01	0.004
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.898553e-01	0.004
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.898553e-01	0.004
Acyl chain remodelling of PG	R-HSA-1482925	9.898553e-01	0.004
Maturation of spike protein	R-HSA-9694548	9.905548e-01	0.004
Inwardly rectifying K+ channels	R-HSA-1296065	9.906119e-01	0.004
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.906885e-01	0.004
Kidney development	R-HSA-9830369	9.908936e-01	0.004
Triglyceride metabolism	R-HSA-8979227	9.914851e-01	0.004
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.914851e-01	0.004
Recycling of bile acids and salts	R-HSA-159418	9.919530e-01	0.004
The phototransduction cascade	R-HSA-2514856	9.924308e-01	0.003
Activation of GABAB receptors	R-HSA-991365	9.928706e-01	0.003
GABA B receptor activation	R-HSA-977444	9.928706e-01	0.003
Cytosolic tRNA aminoacylation	R-HSA-379716	9.928706e-01	0.003
Cellular hexose transport	R-HSA-189200	9.928757e-01	0.003
Neurotoxicity of clostridium toxins	R-HSA-168799	9.928757e-01	0.003
Fructose metabolism	R-HSA-5652084	9.928757e-01	0.003
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.928757e-01	0.003
Acyl chain remodelling of PC	R-HSA-1482788	9.931061e-01	0.003
CS/DS degradation	R-HSA-2024101	9.931061e-01	0.003
SLC-mediated transport of organic anions	R-HSA-9955298	9.932684e-01	0.003
Organic anion transport by SLCO transporters	R-HSA-879518	9.940299e-01	0.003
Free fatty acids regulate insulin secretion	R-HSA-400451	9.940299e-01	0.003
ABC transporters in lipid homeostasis	R-HSA-1369062	9.940299e-01	0.003
Mitochondrial mRNA modification	R-HSA-9937008	9.940299e-01	0.003
Carnitine shuttle	R-HSA-200425	9.940299e-01	0.003
Biosynthesis of maresins	R-HSA-9018682	9.940299e-01	0.003
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.940969e-01	0.003
RA biosynthesis pathway	R-HSA-5365859	9.940969e-01	0.003
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.942032e-01	0.003
Methylation	R-HSA-156581	9.946324e-01	0.002
Acyl chain remodelling of PE	R-HSA-1482839	9.949476e-01	0.002
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.949476e-01	0.002
Thromboxane signalling through TP receptor	R-HSA-428930	9.949971e-01	0.002
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.949971e-01	0.002
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.952195e-01	0.002
Diseases of carbohydrate metabolism	R-HSA-5663084	9.955272e-01	0.002
Formation of the cornified envelope	R-HSA-6809371	9.956408e-01	0.002
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.958077e-01	0.002
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.958077e-01	0.002
Hyaluronan degradation	R-HSA-2160916	9.958077e-01	0.002
Fertilization	R-HSA-1187000	9.958077e-01	0.002
Voltage gated Potassium channels	R-HSA-1296072	9.963039e-01	0.002
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.963039e-01	0.002
Metabolism of folate and pterines	R-HSA-196757	9.963039e-01	0.002
Collagen chain trimerization	R-HSA-8948216	9.963039e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.964601e-01	0.002
Sphingolipid catabolism	R-HSA-9845614	9.964870e-01	0.002
Abacavir ADME	R-HSA-2161522	9.964870e-01	0.002
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.964870e-01	0.002
Dectin-2 family	R-HSA-5621480	9.965967e-01	0.001
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.968406e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.969786e-01	0.001
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.970562e-01	0.001
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.970562e-01	0.001
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.970562e-01	0.001
Triglyceride biosynthesis	R-HSA-75109	9.970562e-01	0.001
Synthesis of PE	R-HSA-1483213	9.970562e-01	0.001
Maturation of hRSV A proteins	R-HSA-9828806	9.970562e-01	0.001
Pentose phosphate pathway	R-HSA-71336	9.973005e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.973865e-01	0.001
Iron assimilation using enterobactin	R-HSA-9638334	9.975332e-01	0.001
Prednisone ADME	R-HSA-9757110	9.975332e-01	0.001
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.976944e-01	0.001
rRNA processing in the mitochondrion	R-HSA-8868766	9.976944e-01	0.001
Tryptophan catabolism	R-HSA-71240	9.976944e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.977404e-01	0.001
Thyroxine biosynthesis	R-HSA-209968	9.979330e-01	0.001
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.979330e-01	0.001
Collagen degradation	R-HSA-1442490	9.980264e-01	0.001
Complex IV assembly	R-HSA-9864848	9.980474e-01	0.001
Heme biosynthesis	R-HSA-189451	9.983199e-01	0.001
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.984023e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.985019e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.986958e-01	0.001
DAG1 glycosylations	R-HSA-8931838	9.987839e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.988347e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.989002e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.989162e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.989576e-01	0.000
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.989811e-01	0.000
Glutamate and glutamine metabolism	R-HSA-8964539	9.991462e-01	0.000
Synthesis of PA	R-HSA-1483166	9.991947e-01	0.000
Hyaluronan metabolism	R-HSA-2142845	9.992846e-01	0.000
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.992846e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.993551e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.993572e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.993919e-01	0.000
Transferrin endocytosis and recycling	R-HSA-917977	9.994006e-01	0.000
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.994006e-01	0.000
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.994006e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.994026e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.994378e-01	0.000
GABA receptor activation	R-HSA-977443	9.994857e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.994857e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.994857e-01	0.000
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.994978e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.995121e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.995121e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.995324e-01	0.000
Neurotransmitter release cycle	R-HSA-112310	9.995333e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.995575e-01	0.000
NCAM1 interactions	R-HSA-419037	9.995792e-01	0.000
SLC-mediated transport of organic cations	R-HSA-549127	9.995792e-01	0.000
Lysine catabolism	R-HSA-71064	9.995792e-01	0.000
Aspirin ADME	R-HSA-9749641	9.996330e-01	0.000
tRNA processing in the mitochondrion	R-HSA-6785470	9.996474e-01	0.000
Purine salvage	R-HSA-74217	9.996474e-01	0.000
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.997046e-01	0.000
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.997046e-01	0.000
PPARA activates gene expression	R-HSA-1989781	9.997173e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.997244e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.997373e-01	0.000
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.997525e-01	0.000
Collagen formation	R-HSA-1474290	9.997578e-01	0.000
Aflatoxin activation and detoxification	R-HSA-5423646	9.997927e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.998212e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.998229e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.998469e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.998545e-01	0.000
Pyrimidine catabolism	R-HSA-73621	9.998781e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.998867e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998895e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.998978e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998998e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999033e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999102e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999102e-01	0.000
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.999144e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999194e-01	0.000
FCGR activation	R-HSA-2029481	9.999292e-01	0.000
Potassium Channels	R-HSA-1296071	9.999598e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999606e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999618e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.999704e-01	0.000
Cytosolic sulfonation of small molecules	R-HSA-156584	9.999704e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999738e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999752e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999800e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999803e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999807e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999811e-01	0.000
Glucuronidation	R-HSA-156588	9.999826e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999849e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999868e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.999878e-01	0.000
Purine catabolism	R-HSA-74259	9.999891e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999892e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999920e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999922e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999922e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999928e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999940e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999940e-01	0.000
Transport of small molecules	R-HSA-382551	9.999954e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999957e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.999960e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999960e-01	0.000
Xenobiotics	R-HSA-211981	9.999970e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999972e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999975e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999983e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999984e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999985e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999991e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999991e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999991e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000
Drug ADME	R-HSA-9748784	9.999995e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999997e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999998e-01	0.000
Keratinization	R-HSA-6805567	9.999998e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999999e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999999e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999999e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999999e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	-0.000