PRKD2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14745 S290 Sugiyama NHERF1 NHERF SLC9A3R1 REALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTA
O14745 S291 Sugiyama NHERF1 NHERF SLC9A3R1 EALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTAP
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15143 S310 Sugiyama ARPC1B ARC41 QSSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVs
O43175 S166 Sugiyama PHGDH PGDH3 KtLGILGLGRIGREVATRMQsFGMKTIGYDPIISPEVSASF
O43615 S180 Sugiyama TIMM44 MIMT44 TIM44 AESVSKGGEKLGRTAAFRALsQGVEsVKKEIDDsVLGQtGP
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60749 S226 Sugiyama SNX2 TRG9 PPAPEKSIVGMTKVKVGKEDssSTEFVEKRRAALERYLQRT
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O96013 S99 PSP PAK4 KIAA1142 DGALTLLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPE
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 GPS6|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237 T428 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB DKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFPA
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12277 S164 Sugiyama CKB CKBB PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15374 S128 Sugiyama UCHL3 KDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRVtH
P15880 S281 Sugiyama RPS2 RPS4 FtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt________
P15880 T278 Sugiyama RPS2 RPS4 EtVFtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt_____
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P17181 S535 PSP IFNAR1 IFNAR EETNQTDEDHKKySSQTsQDsGNysNEDESESKTSEELQQD
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23528 S41 Sugiyama CFL1 CFL RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054 S2129 Sugiyama APC DP2.5 NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S109 Sugiyama RPL13 BBC1 OK/SW-cl.46 KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29692 S133 Sugiyama EEF1D EF1D NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31327 S205 Sugiyama CPS1 FEGQPVDFVDPNKQNLIAEVstKDVKVYGKGNPTKVVAVDC
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P35613 S246 Sugiyama BSG UNQ6505/PRO21383 VKssEHINEGEtAMLVCKSEsVPPVTDWAWyKITDSEDKAL
P36915 S68 Sugiyama GNL1 HSR1 tDtsDGEsVTHHIRRLNQQPsQGLGPRGYDPNRYRLHFERD
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41236 T22 Sugiyama PPP1R2 IPP2 AASTAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSK
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46779 S91 Sugiyama RPL28 RKPAtsyVRttINKNARAtLsSIRHMIRKNKYRPDLRMAAI
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P50552 S157 EPSD|PSP VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50552 S239 EPSD|PSP VASP GGAGAPGLAAAIAGAKLRKVsKQEEAsGGPTAPKAESGRSG
P50552 S322 EPSD|PSP VASP QSEsVRRPWEKNstTLPRMKssssVttsEtQPCtPsSSDyS
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51991 S116 Sugiyama HNRNPA3 HNRPA3 RPHKVDGRVVEPKRAVsREDsVKPGAHLtVKKIFVGGIKED
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57772 S28 Sugiyama EEFSEC SELB VNVGVLGHIDSGKTALARALsTTASTAAFDKQPQSRERGIT
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62857 S23 Sugiyama RPS28 TSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsII
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 Y208 Sugiyama YBX1 NSEP1 YB1 yRRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02880 S1522 Sugiyama TOP2B DTVPKPKRAPKQKKVVEAVNsDsDsEFGIPKKTTtPKGKGR
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06210 T262 Sugiyama GFPT1 GFAT GFPT sQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDAS
Q07666 S35 Sugiyama KHDRBS1 SAM68 sGRsGsMDPsGAHPsVRQtPsRQPPLPHRSRGGGGGSRGGA
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13563 S801 SIGNOR|EPSD|PSP PKD2 TRPP1 TRPP2 DLEKEREDLDLDHssLPRPMssRSFPRSLDDsEEDDDEDSG
Q13596 S229 Sugiyama SNX1 PPPPEKSLIGMTKVKVGKEDsssAEFLEKRRAALERYLQRI
Q13671 S292 GPS6|EPSD|PSP RIN1 GAVPSQTERLPPCQLLRREssVGYRVPAGSGPSLPPMPSLQ
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14247 S298 PSP CTTN EMS1 ERQDsAAVGFDyKEKLAKHEsQQDySKGFGGKyGVQKDRMD
Q14566 S498 Sugiyama MCM6 EQQTISITKAGVKATLNARTsILAAANPIsGHyDRSKSLKQ
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15172 S472 Sugiyama PPP2R5A EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q53EL6 S80 Sugiyama PDCD4 H731 KRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPKGRLL
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5RKV6 S14 Sugiyama EXOSC6 MTR3 _______MPGDHRRIRGPEEsQPPQLyAADEEEAPGTRDPT
Q5UIP0 S1688 Sugiyama RIF1 PVPESNLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssL
Q6FI81 T250 Sugiyama CIAPIN1 CUA001 PRO0915 ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7KZI7 S400 EPSD|PSP MARK2 EMK1 sADLtNssAPsPsHKVQRsVsANPKQRRFsDQAAGPAIPTS
Q86VQ1 S206 Sugiyama GLCCI1 PRDPHVHYPSCMKDKATQTPsCWAEEGAEKRSHQRsAsWGs
Q86W56 S286 Sugiyama PARG VGSEDVGTGPKNDNKLTRQEsCLGNsPPFEKESEPEsPMDV
Q8N1G4 T371 Sugiyama LRRC47 KIAA1185 ALKRFLTSQTKLHEDLCEKRtAAtLAtHELRAVKGPLLYCA
Q8NBP7 S225 Sugiyama PCSK9 NARC1 PSEC0052 FENVPEEDGTRFHRQASKCDsHGtHLAGVVSGRDAGVAKGA
Q8NI08 S208 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 DKLPDADLARKALKPIERVLsstsEEDEPGVVKFLKMNCRY
Q8NI08 S441 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 ELSsQTGGGMHKKDTLKECLsLDPEERKKAESQINNSAVEM
Q8WUI4 S155 SIGNOR HDAC7 HDAC7A PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WUI4 S181 GPS6|EPSD|PSP HDAC7 HDAC7A LRYKPKKSLERRKNPLLRKEsAPPSLRRRPAETLGDSSPSS
Q8WUI4 S358 SIGNOR HDAC7 HDAC7A LMTTERLSGSGLHWPLSRtRsEPLPPSATAPPPPGPMQPRL
Q8WYL5 S937 SIGNOR|EPSD|PSP SSH1 KIAA1298 SSH1L KTICYtPTSSSMSSNLTRsssSDSIHsVRGKPGLVKQRTQE
Q8WYL5 S978 SIGNOR|EPSD|PSP SSH1 KIAA1298 SSH1L IETRLRLAGLTVssPLKRSHsLAKLGsLtFstEDLsSEADP
Q92625 S663 Sugiyama ANKS1A ANKS1 KIAA0229 ODIN sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96N67 S1432 Sugiyama DOCK7 KIAA1771 RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q99543 S275 Sugiyama DNAJC2 MPHOSPH11 MPP11 ZRF1 RAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEKAKKEAEK
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99828 S78 EPSD|PSP CIB1 CIB KIP PRKDCIP ILSLPELKANPFKERICRVFsTSPAKDSLSFEDFLDLLSVF
Q9BXP5 S422 Sugiyama SRRT ARS2 ASR2 EKPKDAAGLECKPRPLHKTCsLFMRNIAPNISRAEIIsLCK
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZL6 S183 Sugiyama PRKD2 PKD2 HSPC187 VRQGLKCDGCGLNYHKRCAFsIPNNCsGARKRRLsstsLAs
Q9BZL6 S189 Sugiyama PRKD2 PKD2 HSPC187 CDGCGLNYHKRCAFsIPNNCsGARKRRLsstsLAsGHsVRL
Q9BZL6 S197 Sugiyama PRKD2 PKD2 HSPC187 HKRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPC
Q9BZL6 S198 Sugiyama PRKD2 PKD2 HSPC187 KRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCT
Q9BZL6 S200 Sugiyama PRKD2 PKD2 HSPC187 CAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTAE
Q9BZL6 S206 Sugiyama PRKD2 PKD2 HSPC187 NNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTAEELsRst
Q9BZL6 S214 Sugiyama PRKD2 PKD2 HSPC187 RRLsstsLAsGHsVRLGtsEsLPCTAEELsRsttELLPRRP
Q9BZL6 S223 Sugiyama PRKD2 PKD2 HSPC187 sGHsVRLGtsEsLPCTAEELsRsttELLPRRPPsssssssA
Q9BZL6 S237 Sugiyama PRKD2 PKD2 HSPC187 CTAEELsRsttELLPRRPPsssssssAssYTGRPIELDKML
Q9BZL6 S240 Sugiyama PRKD2 PKD2 HSPC187 EELsRsttELLPRRPPsssssssAssYTGRPIELDKMLLSK
Q9BZL6 S241 Sugiyama PRKD2 PKD2 HSPC187 ELsRsttELLPRRPPsssssssAssYTGRPIELDKMLLSKV
Q9BZL6 S353 Sugiyama PRKD2 PKD2 HSPC187 SEADKSALMDESEDsGVIPGsHsENALHAsEEEEGEGGKAQ
Q9BZL6 S362 Sugiyama PRKD2 PKD2 HSPC187 DESEDsGVIPGsHsENALHAsEEEEGEGGKAQssLGyIPLM
Q9BZL6 S374 Sugiyama PRKD2 PKD2 HSPC187 HsENALHAsEEEEGEGGKAQssLGyIPLMRVVQSVRHTTRK
Q9BZL6 S375 Sugiyama PRKD2 PKD2 HSPC187 sENALHAsEEEEGEGGKAQssLGyIPLMRVVQSVRHTTRKs
Q9BZL6 S408 Sugiyama PRKD2 PKD2 HSPC187 VRHTTRKsstTLREGWVVHysNKDTLRKRHYWRLDCKCITL
Q9BZL6 S710 Sugiyama PRKD2 PKD2 HSPC187 QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNR
Q9BZL6 S876 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKD2 PKD2 HSPC187 DLGGACPPQDHDMQGLAERIsVL__________________
Q9BZL6 T199 Sugiyama PRKD2 PKD2 HSPC187 RCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTA
Q9BZL6 T211 Sugiyama PRKD2 PKD2 HSPC187 ARKRRLsstsLAsGHsVRLGtsEsLPCTAEELsRsttELLP
Q9BZL6 T227 Sugiyama PRKD2 PKD2 HSPC187 VRLGtsEsLPCTAEELsRsttELLPRRPPsssssssAssYT
Q9BZL6 T433 Sugiyama PRKD2 PKD2 HSPC187 LRKRHYWRLDCKCITLFQNNtTNRYyKEIPLSEILTVESAQ
Q9BZL6 T502 Sugiyama PRKD2 PKD2 HSPC187 PGGTPGGPSGQGAEAARGWEtAIRQALMPVILQDAPsAPGH
Q9BZL6 T714 Sugiyama PRKD2 PKD2 HSPC187 CDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNRSLDM
Q9BZL6 Y378 Sugiyama PRKD2 PKD2 HSPC187 ALHAsEEEEGEGGKAQssLGyIPLMRVVQSVRHTTRKsstT
Q9BZL6 Y407 Sugiyama PRKD2 PKD2 HSPC187 SVRHTTRKsstTLREGWVVHysNKDTLRKRHYWRLDCKCIT
Q9BZL6 Y717 Sugiyama PRKD2 PKD2 HSPC187 GFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNRSLDMWSV
Q9BZL6 Y728 Sugiyama PRKD2 PKD2 HSPC187 RRsVVGtPAyLAPEVLLNQGyNRSLDMWSVGVIMYVSLSGT
Q9C0C9 S399 Sugiyama UBE2O KIAA1734 EGsMAKKVKRLLKKQVVRIMsCsPDtQCsRDHsMEDPDKKG
Q9GZY8 S155 SIGNOR MFF C2orf33 AD030 AD033 GL004 PPttPQNEEIRAVGRLKRERsMsENAVRQNGQLVRNDsLWH
Q9GZY8 S172 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 RERsMsENAVRQNGQLVRNDsLWHRsDsAPRNKISRFQAPI
Q9GZY8 S275 SIGNOR MFF C2orf33 AD030 AD033 GL004 RGGsAAAtsNPHHDNVRYGIsNIDTTIEGTSDDLTVVDAAS
Q9H0H5 S206 Sugiyama RACGAP1 KIAA1478 MGCRACGAP tsRQFVDGPPGPVKKtRsIGsAVDQGNEsIVAKTTVTVPND
Q9H1H9 S1698 Sugiyama KIF13A RBKIN GsPSSQSIPEKNSKSLCRtGsCsELDACPSKISQPARGFCP
Q9H3N1 S270 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H9Q2 S225 Sugiyama COPS7B CSN7B TQQQVEAEVTNIKKTLKAtAsSsAQEMEQQLAERECPPHAE
Q9H9Q2 S227 Sugiyama COPS7B CSN7B QQVEAEVTNIKKTLKAtAsSsAQEMEQQLAERECPPHAEQR
Q9UBF8 S294 SIGNOR|EPSD|PSP PI4KB PIK4CB RsKsDAtAsISLSSNLKRTAsNPKVENEDEELSSSTESIDN
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULL1 S611 Sugiyama PLEKHG1 KIAA1209 GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UMZ2 S752 Sugiyama SYNRG AP1GBP1 SYNG VKGGQNSTAASTKyDVFRQLsLEGsGLGVEDLKDNtPSGKs
Q9UNF1 S264 Sugiyama MAGED2 BCG1 sLRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAN
Q9UQL6 S259 SIGNOR HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR|EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
G alpha (12/13) signalling events R-HSA-416482 4.806371e-08 7.318 0 0
HSF1-dependent transactivation R-HSA-3371571 4.858669e-08 7.313 0 0
Attenuation phase R-HSA-3371568 5.695786e-08 7.244 0 0
NRAGE signals death through JNK R-HSA-193648 7.607288e-07 6.119 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.396765e-06 5.357 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.908842e-06 5.004 0 0
Cellular response to heat stress R-HSA-3371556 1.154084e-05 4.938 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.465778e-05 4.834 0 0
HSF1 activation R-HSA-3371511 1.530042e-05 4.815 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.893194e-05 4.723 0 0
Apoptotic execution phase R-HSA-75153 2.430483e-05 4.614 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.016973e-05 4.520 0 0
Chromatin modifying enzymes R-HSA-3247509 6.548005e-05 4.184 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.374632e-05 4.132 0 0
Chromatin organization R-HSA-4839726 7.846598e-05 4.105 0 0
Signal Transduction R-HSA-162582 1.109462e-04 3.955 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.719090e-04 3.765 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.975710e-04 3.704 0 0
Death Receptor Signaling R-HSA-73887 2.806329e-04 3.552 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.158403e-04 3.501 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.158403e-04 3.501 0 0
Activation of RAC1 R-HSA-428540 4.037157e-04 3.394 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.656628e-04 3.247 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.342621e-04 3.272 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.697928e-04 3.244 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.356538e-04 3.197 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.791573e-04 3.056 0 0
Axon guidance R-HSA-422475 9.294811e-04 3.032 0 0
Signaling by Hippo R-HSA-2028269 1.167530e-03 2.933 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.218666e-03 2.914 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.331765e-03 2.876 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.378353e-03 2.861 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.425361e-03 2.846 0 0
Cell Cycle R-HSA-1640170 1.683589e-03 2.774 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.874390e-03 2.727 0 0
Mitotic Prometaphase R-HSA-68877 1.879487e-03 2.726 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.182601e-03 2.661 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.399512e-03 2.620 0 0
Nervous system development R-HSA-9675108 2.710531e-03 2.567 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.737814e-03 2.563 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.872724e-03 2.542 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.872724e-03 2.542 0 0
RAF activation R-HSA-5673000 3.246725e-03 2.489 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.550942e-03 2.450 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.741550e-03 2.427 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.143695e-03 2.383 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.223514e-03 2.374 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.489494e-03 2.348 0 0
Neurexins and neuroligins R-HSA-6794361 4.662172e-03 2.331 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.999610e-03 2.301 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.332182e-03 2.273 0 0
Regulation of TP53 Activity R-HSA-5633007 5.684621e-03 2.245 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.135390e-03 2.212 0 0
Cell Cycle Checkpoints R-HSA-69620 6.240369e-03 2.205 0 0
Specification of the neural plate border R-HSA-9834899 7.162668e-03 2.145 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.022119e-03 2.096 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.790686e-03 2.108 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.312566e-03 2.080 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.279286e-03 2.032 0 0
Semaphorin interactions R-HSA-373755 9.106338e-03 2.041 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.838662e-03 2.007 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.106126e-02 1.956 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.074123e-02 1.969 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.074123e-02 1.969 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.074123e-02 1.969 0 0
Signaling by RAS mutants R-HSA-6802949 1.074123e-02 1.969 0 0
Long-term potentiation R-HSA-9620244 1.049449e-02 1.979 0 0
Signaling by ROBO receptors R-HSA-376176 1.075983e-02 1.968 0 0
HDMs demethylate histones R-HSA-3214842 1.049449e-02 1.979 0 0
RET signaling R-HSA-8853659 1.203464e-02 1.920 0 0
Calmodulin induced events R-HSA-111933 1.203464e-02 1.920 0 0
CaM pathway R-HSA-111997 1.203464e-02 1.920 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.229441e-02 1.910 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.298285e-02 1.887 0 0
Cell Cycle, Mitotic R-HSA-69278 1.305937e-02 1.884 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.448855e-02 1.839 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.448855e-02 1.839 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.373101e-02 1.862 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.411576e-02 1.850 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.448855e-02 1.839 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.373101e-02 1.862 0 0
EPH-Ephrin signaling R-HSA-2682334 1.586368e-02 1.800 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.781520e-02 1.749 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.795489e-02 1.746 0 0
Ephrin signaling R-HSA-3928664 1.795489e-02 1.746 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.892879e-02 1.723 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.892879e-02 1.723 0 0
DAG and IP3 signaling R-HSA-1489509 2.111457e-02 1.675 0 0
Signaling by APC mutants R-HSA-4839744 2.356052e-02 1.628 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.356052e-02 1.628 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.356052e-02 1.628 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.356052e-02 1.628 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.342571e-02 1.630 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.342571e-02 1.630 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.307892e-02 1.637 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.373545e-02 1.625 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.587832e-02 1.587 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.788962e-02 1.555 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.038188e-02 1.517 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.038188e-02 1.517 0 0
Signaling by AXIN mutants R-HSA-4839735 3.038188e-02 1.517 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.903679e-02 1.537 0 0
PLC beta mediated events R-HSA-112043 3.045630e-02 1.516 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.311044e-02 1.480 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.155079e-02 1.501 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.311044e-02 1.480 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.233841e-02 1.490 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.233841e-02 1.490 0 0
Dopamine receptors R-HSA-390651 3.233841e-02 1.490 0 0
Post NMDA receptor activation events R-HSA-438064 3.091244e-02 1.510 0 0
Ca-dependent events R-HSA-111996 3.155079e-02 1.501 0 0
RNA Polymerase II Transcription R-HSA-73857 3.289387e-02 1.483 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.832811e-02 1.416 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.832811e-02 1.416 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.832811e-02 1.416 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.832811e-02 1.416 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.832811e-02 1.416 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.568340e-02 1.448 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.796730e-02 1.421 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.832811e-02 1.416 0 0
Type I hemidesmosome assembly R-HSA-446107 3.879615e-02 1.411 0 0
Adrenoceptors R-HSA-390696 3.879615e-02 1.411 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.879615e-02 1.411 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.934380e-02 1.405 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.958933e-02 1.402 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.128435e-02 1.384 0 0
Specification of primordial germ cells R-HSA-9827857 4.274298e-02 1.369 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.284059e-02 1.368 0 0
Notch-HLH transcription pathway R-HSA-350054 4.432942e-02 1.353 0 0
mRNA 3'-end processing R-HSA-72187 4.662988e-02 1.331 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.730120e-02 1.325 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.730120e-02 1.325 0 0
Gene expression (Transcription) R-HSA-74160 4.447084e-02 1.352 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.743179e-02 1.324 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.908662e-02 1.309 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.908662e-02 1.309 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.949029e-02 1.305 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.970731e-02 1.304 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.038047e-02 1.298 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.038047e-02 1.298 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.076600e-02 1.294 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.770929e-02 1.239 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.403924e-02 1.267 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.537571e-02 1.257 0 0
G-protein mediated events R-HSA-112040 5.360777e-02 1.271 0 0
MAPK family signaling cascades R-HSA-5683057 5.298097e-02 1.276 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.441469e-02 1.264 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.779246e-02 1.238 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.782894e-02 1.238 0 0
Centrosome maturation R-HSA-380287 5.862470e-02 1.232 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.956329e-02 1.225 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.993191e-02 1.222 0 0
Rap1 signalling R-HSA-392517 5.993191e-02 1.222 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.993191e-02 1.222 0 0
The NLRP3 inflammasome R-HSA-844456 5.993191e-02 1.222 0 0
Co-stimulation by CD28 R-HSA-389356 6.083409e-02 1.216 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.507278e-02 1.187 0 0
mRNA Splicing R-HSA-72172 6.224632e-02 1.206 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.702501e-02 1.174 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.816554e-02 1.166 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.543938e-02 1.184 0 0
Ion homeostasis R-HSA-5578775 6.816554e-02 1.166 0 0
Signaling by NOTCH1 R-HSA-1980143 6.346851e-02 1.197 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.507278e-02 1.187 0 0
PI Metabolism R-HSA-1483255 6.543938e-02 1.184 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.824970e-02 1.166 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.824970e-02 1.166 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.738154e-02 1.111 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.738154e-02 1.111 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.738154e-02 1.111 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.738154e-02 1.111 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.986431e-02 1.156 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.986431e-02 1.156 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.986431e-02 1.156 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.986431e-02 1.156 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.986431e-02 1.156 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.946173e-02 1.158 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.727080e-02 1.112 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.968271e-02 1.157 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.727080e-02 1.112 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.986431e-02 1.156 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.946173e-02 1.158 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.765537e-02 1.110 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.856874e-02 1.105 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.942659e-02 1.100 0 0
Amine ligand-binding receptors R-HSA-375280 7.942659e-02 1.100 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.068857e-02 1.093 0 0
Cellular Senescence R-HSA-2559583 8.075167e-02 1.093 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.177352e-02 1.087 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.201246e-02 1.086 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.258970e-02 1.083 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.258970e-02 1.083 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.543792e-02 1.068 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.777840e-02 1.057 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 9.505835e-02 1.022 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.204218e-02 1.036 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.543792e-02 1.068 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.505835e-02 1.022 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.478416e-02 1.072 0 0
Generic Transcription Pathway R-HSA-212436 9.394760e-02 1.027 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.416061e-02 1.075 0 0
Interleukin-2 family signaling R-HSA-451927 9.443217e-02 1.025 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.239436e-02 1.034 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.239436e-02 1.034 0 0
Diseases of DNA repair R-HSA-9675135 9.553917e-02 1.020 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.615386e-02 1.017 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.079257e-01 0.967 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.079257e-01 0.967 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.042091e-01 0.690 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.042091e-01 0.690 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.042091e-01 0.690 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.042091e-01 0.690 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.042091e-01 0.690 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.042091e-01 0.690 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.042091e-01 0.690 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.042091e-01 0.690 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.042091e-01 0.690 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.042091e-01 0.690 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.042091e-01 0.690 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.042091e-01 0.690 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.124298e-01 0.949 0 0
Invadopodia formation R-HSA-8941237 1.124298e-01 0.949 0 0
Regulation of gap junction activity R-HSA-191650 1.506616e-01 0.822 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.506616e-01 0.822 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.506616e-01 0.822 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.506616e-01 0.822 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.506616e-01 0.822 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.506616e-01 0.822 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.506616e-01 0.822 0 0
FGFR4 mutant receptor activation R-HSA-1839128 2.901055e-01 0.537 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.901055e-01 0.537 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.901055e-01 0.537 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.901055e-01 0.537 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.901055e-01 0.537 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.901055e-01 0.537 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.901055e-01 0.537 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.901055e-01 0.537 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.901055e-01 0.537 0 0
Intestinal infectious diseases R-HSA-8942233 2.901055e-01 0.537 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.901055e-01 0.537 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.901055e-01 0.537 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.901055e-01 0.537 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.901055e-01 0.537 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.901055e-01 0.537 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.901055e-01 0.537 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.081342e-01 0.966 0 0
Regulation of PTEN localization R-HSA-8948747 1.081342e-01 0.966 0 0
SOS-mediated signalling R-HSA-112412 1.081342e-01 0.966 0 0
IRS activation R-HSA-74713 1.909824e-01 0.719 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.909824e-01 0.719 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 1.909824e-01 0.719 0 0
G2 Phase R-HSA-68911 1.909824e-01 0.719 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.328713e-01 0.877 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.593459e-01 0.798 0 0
ALK mutants bind TKIs R-HSA-9700645 1.593459e-01 0.798 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.324966e-01 0.634 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.324966e-01 0.634 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.324966e-01 0.634 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.324966e-01 0.634 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.324966e-01 0.634 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.324966e-01 0.634 0 0
Signaling by MAPK mutants R-HSA-9652817 2.324966e-01 0.634 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.667348e-01 0.436 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.667348e-01 0.436 0 0
Potassium transport channels R-HSA-1296067 3.667348e-01 0.436 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.667348e-01 0.436 0 0
PI3K/AKT activation R-HSA-198203 1.872530e-01 0.728 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.872530e-01 0.728 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.872530e-01 0.728 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.529561e-01 0.815 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.744774e-01 0.561 0 0
CREB phosphorylation R-HSA-199920 2.744774e-01 0.561 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.744774e-01 0.561 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 2.744774e-01 0.561 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.744774e-01 0.561 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.262320e-01 0.899 0 0
PKA activation R-HSA-163615 1.262320e-01 0.899 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.162947e-01 0.665 0 0
DCC mediated attractive signaling R-HSA-418885 1.746554e-01 0.758 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.746554e-01 0.758 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.183708e-01 0.927 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.608565e-01 0.794 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.973273e-01 0.705 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.461862e-01 0.609 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.461862e-01 0.609 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.461862e-01 0.609 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.163409e-01 0.500 0 0
Netrin mediated repulsion signals R-HSA-418886 3.163409e-01 0.500 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.163409e-01 0.500 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.163409e-01 0.500 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.163409e-01 0.500 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.163409e-01 0.500 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.350965e-01 0.361 0 0
Axonal growth stimulation R-HSA-209563 4.350965e-01 0.361 0 0
MET activates PTPN11 R-HSA-8865999 4.350965e-01 0.361 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.350965e-01 0.361 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.350965e-01 0.361 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.350965e-01 0.361 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.350965e-01 0.361 0 0
Phenylketonuria R-HSA-2160456 4.350965e-01 0.361 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.350965e-01 0.361 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.350965e-01 0.361 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.350965e-01 0.361 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.020893e-01 0.991 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.475656e-01 0.831 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.794597e-01 0.746 0 0
Trafficking of AMPA receptors R-HSA-399719 1.352295e-01 0.869 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.766600e-01 0.558 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.766600e-01 0.558 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.136358e-01 0.944 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.796551e-01 0.746 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.796551e-01 0.746 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.576237e-01 0.447 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.576237e-01 0.447 0 0
Formation of annular gap junctions R-HSA-196025 3.576237e-01 0.447 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.576237e-01 0.447 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.576237e-01 0.447 0 0
Integrin signaling R-HSA-354192 1.628511e-01 0.788 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.134423e-01 0.945 0 0
HIV elongation arrest and recovery R-HSA-167287 1.966638e-01 0.706 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.966638e-01 0.706 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.966638e-01 0.706 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.074692e-01 0.512 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.608454e-01 0.794 0 0
GAB1 signalosome R-HSA-180292 2.697507e-01 0.569 0 0
PKA activation in glucagon signalling R-HSA-164378 2.697507e-01 0.569 0 0
HIV Transcription Elongation R-HSA-167169 1.741780e-01 0.759 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.741780e-01 0.759 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.741780e-01 0.759 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.815181e-02 1.008 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.605737e-01 0.584 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.948918e-01 0.530 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.948918e-01 0.530 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.383887e-01 0.471 0 0
Gap junction degradation R-HSA-190873 3.979635e-01 0.400 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.960819e-01 0.304 0 0
HCN channels R-HSA-1296061 4.960819e-01 0.304 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.960819e-01 0.304 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 4.960819e-01 0.304 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 4.960819e-01 0.304 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.960819e-01 0.304 0 0
ATP sensitive Potassium channels R-HSA-1296025 4.960819e-01 0.304 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.960819e-01 0.304 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.960819e-01 0.304 0 0
Meiotic synapsis R-HSA-1221632 1.657195e-01 0.781 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.426521e-01 0.846 0 0
Erythropoietin activates RAS R-HSA-9027284 3.692165e-01 0.433 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.692165e-01 0.433 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.692165e-01 0.433 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.370831e-01 0.359 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.755507e-01 0.560 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.755507e-01 0.560 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.260276e-01 0.487 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.260276e-01 0.487 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.912920e-01 0.718 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.086510e-01 0.511 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.997731e-01 0.398 0 0
snRNP Assembly R-HSA-191859 2.408598e-01 0.618 0 0
Metabolism of non-coding RNA R-HSA-194441 2.408598e-01 0.618 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.931409e-01 0.533 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.482705e-01 0.458 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.482705e-01 0.458 0 0
Signaling by Erythropoietin R-HSA-9006335 3.705921e-01 0.431 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.705921e-01 0.431 0 0
Late endosomal microautophagy R-HSA-9615710 3.705921e-01 0.431 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.299015e-01 0.367 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.299015e-01 0.367 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.747760e-01 0.324 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.747760e-01 0.324 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.504868e-01 0.259 0 0
Defective F9 activation R-HSA-9673221 5.504868e-01 0.259 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.504868e-01 0.259 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.504868e-01 0.259 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.504868e-01 0.259 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.929174e-01 0.406 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.929174e-01 0.406 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.575520e-01 0.589 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.575520e-01 0.589 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.594664e-01 0.338 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.594664e-01 0.338 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.474199e-01 0.349 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.474199e-01 0.349 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.474199e-01 0.349 0 0
Deadenylation of mRNA R-HSA-429947 4.474199e-01 0.349 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.108944e-01 0.292 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.108944e-01 0.292 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.108944e-01 0.292 0 0
ERKs are inactivated R-HSA-202670 5.108944e-01 0.292 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.108944e-01 0.292 0 0
Transcription of the HIV genome R-HSA-167172 3.703298e-01 0.431 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.284570e-01 0.368 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.853509e-01 0.414 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.592276e-01 0.338 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.388328e-01 0.358 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.680675e-01 0.330 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.164640e-01 0.287 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.453389e-01 0.263 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.453389e-01 0.263 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.453389e-01 0.263 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.453389e-01 0.263 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.453389e-01 0.263 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.990208e-01 0.223 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.990208e-01 0.223 0 0
PDE3B signalling R-HSA-165160 5.990208e-01 0.223 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.990208e-01 0.223 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.990208e-01 0.223 0 0
PKB-mediated events R-HSA-109703 5.990208e-01 0.223 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.990208e-01 0.223 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.990208e-01 0.223 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.990208e-01 0.223 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 5.990208e-01 0.223 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 5.990208e-01 0.223 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.022741e-01 0.299 0 0
Cristae formation R-HSA-8949613 5.202482e-01 0.284 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.930384e-01 0.307 0 0
Acetylcholine binding and downstream events R-HSA-181431 5.780501e-01 0.238 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.780501e-01 0.238 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.780501e-01 0.238 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 5.780501e-01 0.238 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.700650e-01 0.244 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.700650e-01 0.244 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.810519e-01 0.236 0 0
DAP12 signaling R-HSA-2424491 5.881993e-01 0.230 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.954446e-01 0.225 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.090006e-01 0.215 0 0
Removal of the Flap Intermediate R-HSA-69166 6.090006e-01 0.215 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.090006e-01 0.215 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.090006e-01 0.215 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.423170e-01 0.192 0 0
STAT5 Activation R-HSA-9645135 6.423170e-01 0.192 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.423170e-01 0.192 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.026935e-01 0.220 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.381894e-01 0.195 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.381894e-01 0.195 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.381894e-01 0.195 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.381894e-01 0.195 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.381894e-01 0.195 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.431876e-01 0.192 0 0
Striated Muscle Contraction R-HSA-390522 6.693834e-01 0.174 0 0
Phosphorylation of the APC/C R-HSA-176412 6.656360e-01 0.177 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.809406e-01 0.167 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.809406e-01 0.167 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.809406e-01 0.167 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.809406e-01 0.167 0 0
Recycling of eIF2:GDP R-HSA-72731 6.809406e-01 0.167 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.809406e-01 0.167 0 0
FOXO-mediated transcription R-HSA-9614085 2.805578e-01 0.552 0 0
PKR-mediated signaling R-HSA-9833482 4.232078e-01 0.373 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.700650e-01 0.244 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.700650e-01 0.244 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.594664e-01 0.338 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.594664e-01 0.338 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.237391e-01 0.650 0 0
Signaling by EGFR R-HSA-177929 2.017915e-01 0.695 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.697507e-01 0.569 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.630932e-01 0.580 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.711640e-01 0.173 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.151752e-01 0.382 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.140142e-01 0.289 0 0
ESR-mediated signaling R-HSA-8939211 6.245314e-01 0.204 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.683036e-01 0.571 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.884146e-01 0.411 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.780501e-01 0.238 0 0
EGFR downregulation R-HSA-182971 6.095576e-01 0.215 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.328735e-01 0.364 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.328735e-01 0.364 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.208290e-01 0.656 0 0
IRS-mediated signalling R-HSA-112399 3.273481e-01 0.485 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.453389e-01 0.263 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.501669e-01 0.187 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.328735e-01 0.364 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.427029e-01 0.192 0 0
Aggrephagy R-HSA-9646399 2.931409e-01 0.533 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.544562e-01 0.594 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.021789e-01 0.396 0 0
Developmental Cell Lineages R-HSA-9734767 4.758140e-01 0.323 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.608565e-01 0.794 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.119559e-01 0.951 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.475707e-01 0.262 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.381894e-01 0.195 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.657463e-01 0.177 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.230296e-01 0.374 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.775378e-01 0.751 0 0
p75NTR signals via NF-kB R-HSA-193639 3.692165e-01 0.433 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.625172e-01 0.250 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.593459e-01 0.798 0 0
MAP2K and MAPK activation R-HSA-5674135 1.136358e-01 0.944 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.628511e-01 0.788 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.394618e-01 0.621 0 0
PI3K Cascade R-HSA-109704 3.453149e-01 0.462 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.693924e-01 0.433 0 0
Signaling by FGFR4 R-HSA-5654743 5.259213e-01 0.279 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.514928e-01 0.599 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.378011e-01 0.195 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.299015e-01 0.367 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.222972e-01 0.282 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.198264e-01 0.208 0 0
MHC class II antigen presentation R-HSA-2132295 3.987825e-01 0.399 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.205337e-01 0.376 0 0
Signaling by ERBB2 R-HSA-1227986 5.141249e-01 0.289 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.163409e-01 0.500 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.163409e-01 0.500 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.834028e-01 0.416 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.656360e-01 0.177 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.876989e-01 0.312 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.553732e-01 0.449 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.284152e-01 0.484 0 0
Activation of the pre-replicative complex R-HSA-68962 5.881993e-01 0.230 0 0
IGF1R signaling cascade R-HSA-2428924 3.111247e-01 0.507 0 0
Netrin-1 signaling R-HSA-373752 3.838072e-01 0.416 0 0
Homology Directed Repair R-HSA-5693538 3.426998e-01 0.465 0 0
Insulin receptor signalling cascade R-HSA-74751 4.385577e-01 0.358 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.506616e-01 0.822 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.576237e-01 0.447 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.979635e-01 0.400 0 0
Separation of Sister Chromatids R-HSA-2467813 1.067673e-01 0.972 0 0
NF-kB is activated and signals survival R-HSA-209560 5.108944e-01 0.292 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.453389e-01 0.263 0 0
DARPP-32 events R-HSA-180024 5.661716e-01 0.247 0 0
MET promotes cell motility R-HSA-8875878 5.838381e-01 0.234 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.492221e-01 0.348 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.146035e-01 0.382 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.128843e-01 0.672 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.838381e-01 0.234 0 0
TNF signaling R-HSA-75893 5.956069e-01 0.225 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.039421e-01 0.517 0 0
Hedgehog 'off' state R-HSA-5610787 3.913104e-01 0.407 0 0
Signal attenuation R-HSA-74749 1.872530e-01 0.728 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.127229e-01 0.948 0 0
TRP channels R-HSA-3295583 1.632718e-01 0.787 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.453389e-01 0.263 0 0
Opioid Signalling R-HSA-111885 1.734711e-01 0.761 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.094937e-01 0.961 0 0
M Phase R-HSA-68886 1.050689e-01 0.979 0 0
Generation of second messenger molecules R-HSA-202433 2.931409e-01 0.533 0 0
Cardiogenesis R-HSA-9733709 4.592276e-01 0.338 0 0
Cilium Assembly R-HSA-5617833 2.857679e-01 0.544 0 0
Intra-Golgi traffic R-HSA-6811438 4.875996e-01 0.312 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.831017e-01 0.737 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.761161e-01 0.170 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.257471e-01 0.487 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.747556e-01 0.324 0 0
Calcineurin activates NFAT R-HSA-2025928 1.593459e-01 0.798 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.324966e-01 0.634 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.529561e-01 0.815 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.163409e-01 0.500 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.576237e-01 0.447 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.628511e-01 0.788 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.074692e-01 0.512 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.611219e-01 0.793 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.611219e-01 0.793 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.611219e-01 0.793 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.611219e-01 0.793 0 0
Nuclear RNA decay R-HSA-9930044 2.891010e-01 0.539 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.260276e-01 0.487 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.997731e-01 0.398 0 0
Killing mechanisms R-HSA-9664420 3.997731e-01 0.398 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.299015e-01 0.367 0 0
Formation of the posterior neural plate R-HSA-9832991 4.747760e-01 0.324 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.504868e-01 0.259 0 0
Activation of AKT2 R-HSA-165158 5.504868e-01 0.259 0 0
Tight junction interactions R-HSA-420029 4.721436e-01 0.326 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.066358e-01 0.391 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.068963e-01 0.295 0 0
HDL assembly R-HSA-8963896 6.090006e-01 0.215 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.693834e-01 0.174 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.809406e-01 0.167 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.809406e-01 0.167 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.257773e-01 0.487 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.539016e-01 0.451 0 0
Signaling by VEGF R-HSA-194138 1.860177e-01 0.730 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.643111e-01 0.248 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.643111e-01 0.248 0 0
Cyclin D associated events in G1 R-HSA-69231 2.473661e-01 0.607 0 0
G1 Phase R-HSA-69236 2.473661e-01 0.607 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.412705e-01 0.617 0 0
Selective autophagy R-HSA-9663891 3.195193e-01 0.496 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.809033e-01 0.318 0 0
Autophagy R-HSA-9612973 4.294042e-01 0.367 0 0
Integration of energy metabolism R-HSA-163685 3.883186e-01 0.411 0 0
Macroautophagy R-HSA-1632852 3.525665e-01 0.453 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.697507e-01 0.569 0 0
Interleukin-2 signaling R-HSA-9020558 4.747760e-01 0.324 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.471742e-01 0.459 0 0
Activation of BH3-only proteins R-HSA-114452 5.881993e-01 0.230 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.262320e-01 0.899 0 0
Signaling by WNT in cancer R-HSA-4791275 2.698249e-01 0.569 0 0
Meiosis R-HSA-1500620 2.701938e-01 0.568 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.780501e-01 0.238 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.439175e-01 0.264 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.592276e-01 0.338 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.786715e-01 0.422 0 0
Frs2-mediated activation R-HSA-170968 5.780501e-01 0.238 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.090031e-01 0.963 0 0
Leukotriene receptors R-HSA-391906 2.744774e-01 0.561 0 0
Polo-like kinase mediated events R-HSA-156711 1.262320e-01 0.899 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.350965e-01 0.361 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.960819e-01 0.304 0 0
G-protein beta:gamma signalling R-HSA-397795 2.891010e-01 0.539 0 0
Regulation of CDH11 function R-HSA-9762292 4.370831e-01 0.359 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.504868e-01 0.259 0 0
HATs acetylate histones R-HSA-3214847 2.805578e-01 0.552 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.594664e-01 0.338 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.594664e-01 0.338 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.990208e-01 0.223 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.875996e-01 0.312 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.423170e-01 0.192 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.423170e-01 0.192 0 0
p38MAPK events R-HSA-171007 6.381894e-01 0.195 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.381894e-01 0.195 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.427029e-01 0.192 0 0
Mitotic Anaphase R-HSA-68882 1.047658e-01 0.980 0 0
Signaling by SCF-KIT R-HSA-1433557 3.654584e-01 0.437 0 0
Mismatch Repair R-HSA-5358508 4.883526e-01 0.311 0 0
Mitotic Prophase R-HSA-68875 5.656008e-01 0.247 0 0
Cardiac conduction R-HSA-5576891 4.154544e-01 0.381 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.299015e-01 0.367 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.964413e-01 0.304 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.455364e-01 0.263 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.090006e-01 0.215 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.423170e-01 0.192 0 0
Hedgehog 'on' state R-HSA-5632684 6.792510e-01 0.168 0 0
Muscle contraction R-HSA-397014 3.375899e-01 0.472 0 0
Neuronal System R-HSA-112316 4.561542e-01 0.341 0 0
Heme signaling R-HSA-9707616 1.831017e-01 0.737 0 0
Transmission across Chemical Synapses R-HSA-112315 6.591760e-01 0.181 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.979635e-01 0.400 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.594664e-01 0.338 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.656360e-01 0.177 0 0
Signaling by Hedgehog R-HSA-5358351 5.988788e-01 0.223 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.016457e-01 0.993 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.226085e-01 0.374 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.964413e-01 0.304 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.637358e-01 0.249 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.474199e-01 0.349 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.721436e-01 0.326 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.625172e-01 0.250 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.609792e-01 0.180 0 0
Prolonged ERK activation events R-HSA-169893 6.656360e-01 0.177 0 0
Metabolism of RNA R-HSA-8953854 5.459360e-01 0.263 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.796551e-01 0.746 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.501669e-01 0.187 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.086643e-01 0.964 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.880682e-01 0.312 0 0
Inhibition of PKR R-HSA-169131 2.042091e-01 0.690 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.124298e-01 0.949 0 0
MTF1 activates gene expression R-HSA-5660489 1.506616e-01 0.822 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.667348e-01 0.436 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.667348e-01 0.436 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.667348e-01 0.436 0 0
Regulation of KIT signaling R-HSA-1433559 1.529561e-01 0.815 0 0
Bicarbonate transporters R-HSA-425381 2.162947e-01 0.665 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.350965e-01 0.361 0 0
MET interacts with TNS proteins R-HSA-8875513 4.350965e-01 0.361 0 0
Signaling by LTK R-HSA-9842663 2.766600e-01 0.558 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.576237e-01 0.447 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.697507e-01 0.569 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.370831e-01 0.359 0 0
Kinesins R-HSA-983189 2.544562e-01 0.594 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.747760e-01 0.324 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.504868e-01 0.259 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.504868e-01 0.259 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.504868e-01 0.259 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.051720e-01 0.515 0 0
Sodium/Calcium exchangers R-HSA-425561 5.108944e-01 0.292 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.883526e-01 0.311 0 0
Reproduction R-HSA-1474165 3.151318e-01 0.502 0 0
Metalloprotease DUBs R-HSA-5689901 4.964413e-01 0.304 0 0
Phosphorylation of Emi1 R-HSA-176417 5.990208e-01 0.223 0 0
Formation of the Editosome R-HSA-75094 5.990208e-01 0.223 0 0
Signalling to ERKs R-HSA-187687 5.232930e-01 0.281 0 0
TBC/RABGAPs R-HSA-8854214 5.259213e-01 0.279 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.435077e-01 0.265 0 0
Signalling to RAS R-HSA-167044 5.700650e-01 0.244 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.661716e-01 0.247 0 0
Platelet calcium homeostasis R-HSA-418360 5.661716e-01 0.247 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.755886e-01 0.240 0 0
cGMP effects R-HSA-418457 6.090006e-01 0.215 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.905780e-01 0.229 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.030730e-01 0.220 0 0
Diseases of Immune System R-HSA-5260271 6.217908e-01 0.206 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.217908e-01 0.206 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.693834e-01 0.174 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.809406e-01 0.167 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.809406e-01 0.167 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.945880e-01 0.711 0 0
Signaling by PTK6 R-HSA-8848021 1.945880e-01 0.711 0 0
Gastrulation R-HSA-9758941 6.287387e-01 0.202 0 0
GPVI-mediated activation cascade R-HSA-114604 3.683532e-01 0.434 0 0
Signaling by FGFR in disease R-HSA-1226099 5.917626e-01 0.228 0 0
Signal amplification R-HSA-392518 5.022741e-01 0.299 0 0
Regulation of insulin secretion R-HSA-422356 4.753102e-01 0.323 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.964413e-01 0.304 0 0
G2/M Transition R-HSA-69275 1.453887e-01 0.837 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.198264e-01 0.208 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.273481e-01 0.485 0 0
Signaling by ERBB4 R-HSA-1236394 4.606346e-01 0.337 0 0
FLT3 signaling in disease R-HSA-9682385 5.439175e-01 0.264 0 0
RMTs methylate histone arginines R-HSA-3214858 5.446418e-01 0.264 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.628511e-01 0.788 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.164640e-01 0.287 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.465266e-01 0.262 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.204153e-01 0.207 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.693834e-01 0.174 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.809406e-01 0.167 0 0
FLT3 Signaling R-HSA-9607240 1.879840e-01 0.726 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.680675e-01 0.330 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.501060e-01 0.824 0 0
Downstream signal transduction R-HSA-186763 2.508830e-01 0.601 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.100180e-01 0.509 0 0
Smooth Muscle Contraction R-HSA-445355 3.962614e-01 0.402 0 0
Glycolysis R-HSA-70171 2.918391e-01 0.535 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.205337e-01 0.376 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.205337e-01 0.376 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.576237e-01 0.447 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.370831e-01 0.359 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.299015e-01 0.367 0 0
Programmed Cell Death R-HSA-5357801 1.260792e-01 0.899 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.486438e-01 0.261 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.068963e-01 0.295 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.095576e-01 0.215 0 0
Cellular responses to stress R-HSA-2262752 3.887205e-01 0.410 0 0
Neurodegenerative Diseases R-HSA-8863678 4.474199e-01 0.349 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.474199e-01 0.349 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.016349e-01 0.300 0 0
Apoptosis R-HSA-109581 9.735770e-02 1.012 0 0
G0 and Early G1 R-HSA-1538133 1.487374e-01 0.828 0 0
NGF-stimulated transcription R-HSA-9031628 1.958197e-01 0.708 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.154950e-01 0.381 0 0
Muscarinic acetylcholine receptors R-HSA-390648 1.909824e-01 0.719 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.593459e-01 0.798 0 0
Interleukin-1 processing R-HSA-448706 1.593459e-01 0.798 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.324966e-01 0.634 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.746554e-01 0.758 0 0
Basigin interactions R-HSA-210991 1.794597e-01 0.746 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.074692e-01 0.512 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.979635e-01 0.400 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.960819e-01 0.304 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.969987e-01 0.401 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.148011e-01 0.502 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.990208e-01 0.223 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.990208e-01 0.223 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.198264e-01 0.208 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.579167e-01 0.802 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.465266e-01 0.262 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.611219e-01 0.793 0 0
Signaling by NTRKs R-HSA-166520 1.037373e-01 0.984 0 0
Cellular responses to stimuli R-HSA-8953897 4.118517e-01 0.385 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.979635e-01 0.400 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.518873e-01 0.454 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.202482e-01 0.284 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.780501e-01 0.238 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.780501e-01 0.238 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.661716e-01 0.247 0 0
Regulation of BACH1 activity R-HSA-9708530 6.656360e-01 0.177 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.656360e-01 0.177 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.747807e-01 0.426 0 0
Rab regulation of trafficking R-HSA-9007101 6.337664e-01 0.198 0 0
Formation of the nephric duct R-HSA-9830364 1.475656e-01 0.831 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.697507e-01 0.569 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.692165e-01 0.433 0 0
Inflammasomes R-HSA-622312 1.966638e-01 0.706 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.308149e-01 0.883 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.969987e-01 0.401 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.063866e-01 0.685 0 0
Signaling by KIT in disease R-HSA-9669938 6.198264e-01 0.208 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.901055e-01 0.537 0 0
DSCAM interactions R-HSA-376172 3.667348e-01 0.436 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.262320e-01 0.899 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.162947e-01 0.665 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.350965e-01 0.361 0 0
Alpha-defensins R-HSA-1462054 3.576237e-01 0.447 0 0
Maturation of nucleoprotein R-HSA-9683610 3.074692e-01 0.512 0 0
Sensory perception of sour taste R-HSA-9729555 4.960819e-01 0.304 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.891010e-01 0.539 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 4.370831e-01 0.359 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.332900e-01 0.632 0 0
Disorders of Developmental Biology R-HSA-9675151 4.299015e-01 0.367 0 0
Transport of RCbl within the body R-HSA-9758890 4.747760e-01 0.324 0 0
Synthesis of PI R-HSA-1483226 4.747760e-01 0.324 0 0
PTK6 Down-Regulation R-HSA-8849472 5.504868e-01 0.259 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.504868e-01 0.259 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.504868e-01 0.259 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.108944e-01 0.292 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.964413e-01 0.304 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.990208e-01 0.223 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.022741e-01 0.299 0 0
Creatine metabolism R-HSA-71288 5.437223e-01 0.265 0 0
Abacavir transmembrane transport R-HSA-2161517 6.423170e-01 0.192 0 0
Activation of SMO R-HSA-5635838 6.656360e-01 0.177 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.656360e-01 0.177 0 0
VLDL clearance R-HSA-8964046 6.809406e-01 0.167 0 0
Glucose metabolism R-HSA-70326 4.278476e-01 0.369 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.324296e-01 0.274 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.554576e-01 0.183 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.828224e-01 0.548 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.260276e-01 0.487 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.954446e-01 0.225 0 0
RUNX2 regulates bone development R-HSA-8941326 5.439175e-01 0.264 0 0
Nephrin family interactions R-HSA-373753 5.437223e-01 0.265 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.593459e-01 0.798 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.802838e-01 0.420 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.273615e-01 0.202 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.609792e-01 0.180 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.872530e-01 0.728 0 0
PECAM1 interactions R-HSA-210990 2.162947e-01 0.665 0 0
Integration of provirus R-HSA-162592 5.108944e-01 0.292 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.381894e-01 0.195 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.202482e-01 0.284 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.860429e-01 0.413 0 0
Formation of the anterior neural plate R-HSA-9823739 3.692165e-01 0.433 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.594664e-01 0.338 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 5.437223e-01 0.265 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.767589e-01 0.239 0 0
Signaling by ALK in cancer R-HSA-9700206 3.860429e-01 0.413 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.789238e-01 0.555 0 0
NrCAM interactions R-HSA-447038 1.909824e-01 0.719 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.324966e-01 0.634 0 0
NADPH regeneration R-HSA-389542 2.744774e-01 0.561 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.163409e-01 0.500 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.163409e-01 0.500 0 0
Interleukin-18 signaling R-HSA-9012546 3.576237e-01 0.447 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.960819e-01 0.304 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.504868e-01 0.259 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.504868e-01 0.259 0 0
Co-inhibition by BTLA R-HSA-9927353 5.504868e-01 0.259 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.990208e-01 0.223 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.990208e-01 0.223 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.780501e-01 0.238 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.423170e-01 0.192 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.604808e-01 0.180 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.431876e-01 0.192 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.656360e-01 0.177 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.809406e-01 0.167 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.809406e-01 0.167 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.809406e-01 0.167 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.582456e-01 0.588 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.751721e-01 0.426 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.804703e-01 0.167 0 0
Interleukin-7 signaling R-HSA-1266695 4.721436e-01 0.326 0 0
Platelet sensitization by LDL R-HSA-432142 2.697507e-01 0.569 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.453389e-01 0.263 0 0
Protein methylation R-HSA-8876725 6.381894e-01 0.195 0 0
Other semaphorin interactions R-HSA-416700 6.381894e-01 0.195 0 0
Stimuli-sensing channels R-HSA-2672351 6.124938e-01 0.213 0 0
Maturation of nucleoprotein R-HSA-9694631 5.164640e-01 0.287 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.164640e-01 0.287 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.185946e-01 0.660 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.576237e-01 0.447 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.370831e-01 0.359 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.504868e-01 0.259 0 0
Pervasive developmental disorders R-HSA-9005895 5.453389e-01 0.263 0 0
Disorders of Nervous System Development R-HSA-9697154 5.453389e-01 0.263 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.453389e-01 0.263 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.990208e-01 0.223 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.990208e-01 0.223 0 0
Signal regulatory protein family interactions R-HSA-391160 6.090006e-01 0.215 0 0
Lipid particle organization R-HSA-8964572 6.423170e-01 0.192 0 0
Nef and signal transduction R-HSA-164944 6.423170e-01 0.192 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.381894e-01 0.195 0 0
CHL1 interactions R-HSA-447041 6.809406e-01 0.167 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.809406e-01 0.167 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.623974e-01 0.250 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.159235e-01 0.210 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.697507e-01 0.569 0 0
Interleukin-15 signaling R-HSA-8983432 2.766600e-01 0.558 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.458759e-01 0.461 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.439175e-01 0.264 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.381894e-01 0.195 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.284152e-01 0.484 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.504868e-01 0.259 0 0
Neurofascin interactions R-HSA-447043 6.423170e-01 0.192 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.030730e-01 0.220 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.257471e-01 0.487 0 0
OAS antiviral response R-HSA-8983711 5.453389e-01 0.263 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.656360e-01 0.177 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.804703e-01 0.167 0 0
Growth hormone receptor signaling R-HSA-982772 6.431876e-01 0.192 0 0
Signaling by Leptin R-HSA-2586552 4.370831e-01 0.359 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.780501e-01 0.238 0 0
Interleukin-12 signaling R-HSA-9020591 4.904328e-01 0.309 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.090006e-01 0.215 0 0
Interleukin-37 signaling R-HSA-9008059 2.323357e-01 0.634 0 0
Interleukin-12 family signaling R-HSA-447115 6.561482e-01 0.183 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.833996e-01 0.165 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.846379e-01 0.165 0 0
Mitochondrial protein import R-HSA-1268020 6.864436e-01 0.163 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.868070e-01 0.163 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.868070e-01 0.163 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.868070e-01 0.163 0 0
TGFBR3 expression R-HSA-9839394 6.868070e-01 0.163 0 0
Mitophagy R-HSA-5205647 6.878607e-01 0.162 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.913763e-01 0.160 0 0
Phase 2 - plateau phase R-HSA-5576893 6.913763e-01 0.160 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.913763e-01 0.160 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.913763e-01 0.160 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.913763e-01 0.160 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.913763e-01 0.160 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.913763e-01 0.160 0 0
Synthesis of PG R-HSA-1483148 6.913763e-01 0.160 0 0
Response to metal ions R-HSA-5660526 6.913763e-01 0.160 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.924136e-01 0.160 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.954535e-01 0.158 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.004622e-01 0.155 0 0
Adipogenesis R-HSA-9843745 7.029402e-01 0.153 0 0
HIV Life Cycle R-HSA-162587 7.031046e-01 0.153 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.052286e-01 0.152 0 0
Oncogene Induced Senescence R-HSA-2559585 7.055948e-01 0.151 0 0
S Phase R-HSA-69242 7.058714e-01 0.151 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.070660e-01 0.151 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.070660e-01 0.151 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.153955e-01 0.145 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.153955e-01 0.145 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.153955e-01 0.145 0 0
MET receptor recycling R-HSA-8875656 7.153955e-01 0.145 0 0
Regulation by c-FLIP R-HSA-3371378 7.153955e-01 0.145 0 0
Co-stimulation by ICOS R-HSA-9927354 7.153955e-01 0.145 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.153955e-01 0.145 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.153955e-01 0.145 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.153955e-01 0.145 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.153955e-01 0.145 0 0
Dimerization of procaspase-8 R-HSA-69416 7.153955e-01 0.145 0 0
RSK activation R-HSA-444257 7.153955e-01 0.145 0 0
Sodium/Proton exchangers R-HSA-425986 7.153955e-01 0.145 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.154587e-01 0.145 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.154587e-01 0.145 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.154587e-01 0.145 0 0
Interferon gamma signaling R-HSA-877300 7.202548e-01 0.143 0 0
L1CAM interactions R-HSA-373760 7.204441e-01 0.142 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.223836e-01 0.141 0 0
Nucleosome assembly R-HSA-774815 7.223836e-01 0.141 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.223836e-01 0.141 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.223836e-01 0.141 0 0
Signaling by FGFR3 R-HSA-5654741 7.223836e-01 0.141 0 0
G1/S-Specific Transcription R-HSA-69205 7.225856e-01 0.141 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.225856e-01 0.141 0 0
HDACs deacetylate histones R-HSA-3214815 7.239883e-01 0.140 0 0
Signaling by NOTCH3 R-HSA-9012852 7.239883e-01 0.140 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.263038e-01 0.139 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.263038e-01 0.139 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.263651e-01 0.139 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.333456e-01 0.135 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.354839e-01 0.133 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.371258e-01 0.132 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.371258e-01 0.132 0 0
Signaling by FGFR1 R-HSA-5654736 7.375347e-01 0.132 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.379409e-01 0.132 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.379409e-01 0.132 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.379409e-01 0.132 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.379409e-01 0.132 0 0
Tie2 Signaling R-HSA-210993 7.379409e-01 0.132 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.379409e-01 0.132 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.388373e-01 0.131 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.388373e-01 0.131 0 0
NCAM1 interactions R-HSA-419037 7.388373e-01 0.131 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.391693e-01 0.131 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 7.391693e-01 0.131 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.402176e-01 0.131 0 0
G2/M Checkpoints R-HSA-69481 7.438805e-01 0.128 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.443970e-01 0.128 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.445371e-01 0.128 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.445371e-01 0.128 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.461315e-01 0.127 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.461315e-01 0.127 0 0
Lipophagy R-HSA-9613354 7.461315e-01 0.127 0 0
Interleukin-21 signaling R-HSA-9020958 7.461315e-01 0.127 0 0
WNT mediated activation of DVL R-HSA-201688 7.461315e-01 0.127 0 0
CASP8 activity is inhibited R-HSA-5218900 7.461315e-01 0.127 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.461315e-01 0.127 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.461315e-01 0.127 0 0
ARMS-mediated activation R-HSA-170984 7.461315e-01 0.127 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.461315e-01 0.127 0 0
Unwinding of DNA R-HSA-176974 7.461315e-01 0.127 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.461315e-01 0.127 0 0
mRNA Editing R-HSA-75072 7.461315e-01 0.127 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.461315e-01 0.127 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.461315e-01 0.127 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.461315e-01 0.127 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.461315e-01 0.127 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.461315e-01 0.127 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.489169e-01 0.126 0 0
Recycling pathway of L1 R-HSA-437239 7.512873e-01 0.124 0 0
DNA Double Strand Break Response R-HSA-5693606 7.513278e-01 0.124 0 0
Kidney development R-HSA-9830369 7.513278e-01 0.124 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.543572e-01 0.122 0 0
Deubiquitination R-HSA-5688426 7.543720e-01 0.122 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.588878e-01 0.120 0 0
Other interleukin signaling R-HSA-449836 7.588878e-01 0.120 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.588878e-01 0.120 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.588878e-01 0.120 0 0
mRNA Capping R-HSA-72086 7.617875e-01 0.118 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.617875e-01 0.118 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.617875e-01 0.118 0 0
Regulated Necrosis R-HSA-5218859 7.630764e-01 0.117 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.630764e-01 0.117 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.631864e-01 0.117 0 0
Ub-specific processing proteases R-HSA-5689880 7.643414e-01 0.117 0 0
GPER1 signaling R-HSA-9634597 7.648725e-01 0.116 0 0
Developmental Biology R-HSA-1266738 7.659516e-01 0.116 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.675709e-01 0.115 0 0
Signaling by ALK R-HSA-201556 7.691557e-01 0.114 0 0
Phospholipid metabolism R-HSA-1483257 7.708862e-01 0.113 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.735497e-01 0.112 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.735497e-01 0.112 0 0
2-LTR circle formation R-HSA-164843 7.735497e-01 0.112 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.735497e-01 0.112 0 0
DNA replication initiation R-HSA-68952 7.735497e-01 0.112 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.735497e-01 0.112 0 0
Formation of apoptosome R-HSA-111458 7.735497e-01 0.112 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.735497e-01 0.112 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.735497e-01 0.112 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.735497e-01 0.112 0 0
Pexophagy R-HSA-9664873 7.735497e-01 0.112 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.735497e-01 0.112 0 0
Maturation of spike protein R-HSA-9683686 7.735497e-01 0.112 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.735497e-01 0.112 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.735497e-01 0.112 0 0
Serotonin receptors R-HSA-390666 7.735497e-01 0.112 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.735497e-01 0.112 0 0
Sensory processing of sound R-HSA-9659379 7.746523e-01 0.111 0 0
Peptide chain elongation R-HSA-156902 7.756426e-01 0.110 0 0
Cellular response to chemical stress R-HSA-9711123 7.767485e-01 0.110 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.771569e-01 0.109 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.778878e-01 0.109 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.778878e-01 0.109 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.780803e-01 0.109 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.780803e-01 0.109 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.780803e-01 0.109 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.780803e-01 0.109 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.780803e-01 0.109 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.783686e-01 0.109 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.783686e-01 0.109 0 0
Signaling by NODAL R-HSA-1181150 7.783686e-01 0.109 0 0
Protein hydroxylation R-HSA-9629569 7.783686e-01 0.109 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.832458e-01 0.106 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.832458e-01 0.106 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.832458e-01 0.106 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.832458e-01 0.106 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.832458e-01 0.106 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.832458e-01 0.106 0 0
Cell-Cell communication R-HSA-1500931 7.839128e-01 0.106 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.849735e-01 0.105 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.853521e-01 0.105 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.869363e-01 0.104 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.869363e-01 0.104 0 0
Platelet homeostasis R-HSA-418346 7.879119e-01 0.104 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.934443e-01 0.100 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.934443e-01 0.100 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.949419e-01 0.100 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.954740e-01 0.099 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.954740e-01 0.099 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.954740e-01 0.099 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.958860e-01 0.099 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.958860e-01 0.099 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.964556e-01 0.099 0 0
Lagging Strand Synthesis R-HSA-69186 7.964556e-01 0.099 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.964556e-01 0.099 0 0
ERK/MAPK targets R-HSA-198753 7.964556e-01 0.099 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.964556e-01 0.099 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.964556e-01 0.099 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.966428e-01 0.099 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.966428e-01 0.099 0 0
Interferon Signaling R-HSA-913531 7.978577e-01 0.098 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.980082e-01 0.098 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.980082e-01 0.098 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.980082e-01 0.098 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.980082e-01 0.098 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.980082e-01 0.098 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.980082e-01 0.098 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.980082e-01 0.098 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.980082e-01 0.098 0 0
LGI-ADAM interactions R-HSA-5682910 7.980082e-01 0.098 0 0
Suppression of apoptosis R-HSA-9635465 7.980082e-01 0.098 0 0
Prostanoid ligand receptors R-HSA-391908 7.980082e-01 0.098 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.981107e-01 0.098 0 0
Signaling by TGFB family members R-HSA-9006936 8.008594e-01 0.096 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.040430e-01 0.095 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.048782e-01 0.094 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.048782e-01 0.094 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.048782e-01 0.094 0 0
Signaling by Interleukins R-HSA-449147 8.051315e-01 0.094 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.059258e-01 0.094 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.059258e-01 0.094 0 0
G1/S Transition R-HSA-69206 8.072596e-01 0.093 0 0
DNA strand elongation R-HSA-69190 8.079105e-01 0.093 0 0
Signaling by PDGF R-HSA-186797 8.088271e-01 0.092 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.093637e-01 0.092 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.093637e-01 0.092 0 0
HIV Transcription Initiation R-HSA-167161 8.093637e-01 0.092 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.093637e-01 0.092 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.093637e-01 0.092 0 0
Translation of Structural Proteins R-HSA-9683701 8.093637e-01 0.092 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.101702e-01 0.091 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.111086e-01 0.091 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.129774e-01 0.090 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.132226e-01 0.090 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.132226e-01 0.090 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.132226e-01 0.090 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.132226e-01 0.090 0 0
Glutathione synthesis and recycling R-HSA-174403 8.132226e-01 0.090 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.132226e-01 0.090 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.136040e-01 0.090 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.198262e-01 0.086 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.198262e-01 0.086 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.198262e-01 0.086 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.198262e-01 0.086 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.198262e-01 0.086 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.198262e-01 0.086 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.198262e-01 0.086 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.198262e-01 0.086 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.198262e-01 0.086 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.198262e-01 0.086 0 0
TCR signaling R-HSA-202403 8.208236e-01 0.086 0 0
Selenocysteine synthesis R-HSA-2408557 8.208413e-01 0.086 0 0
Signaling by Insulin receptor R-HSA-74752 8.214269e-01 0.085 0 0
Membrane Trafficking R-HSA-199991 8.214835e-01 0.085 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.215119e-01 0.085 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.215119e-01 0.085 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.215119e-01 0.085 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.244364e-01 0.084 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.285499e-01 0.082 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.285499e-01 0.082 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.287437e-01 0.082 0 0
FGFR2 alternative splicing R-HSA-6803529 8.287437e-01 0.082 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.287437e-01 0.082 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.287437e-01 0.082 0 0
LDL clearance R-HSA-8964038 8.287437e-01 0.082 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.287437e-01 0.082 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.287437e-01 0.082 0 0
Ion transport by P-type ATPases R-HSA-936837 8.289191e-01 0.081 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.304228e-01 0.081 0 0
Cell junction organization R-HSA-446728 8.304244e-01 0.081 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.328529e-01 0.079 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.341156e-01 0.079 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.342829e-01 0.079 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.342829e-01 0.079 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.342829e-01 0.079 0 0
Inositol phosphate metabolism R-HSA-1483249 8.357683e-01 0.078 0 0
Leading Strand Synthesis R-HSA-69109 8.392887e-01 0.076 0 0
Polymerase switching R-HSA-69091 8.392887e-01 0.076 0 0
MET activates RAS signaling R-HSA-8851805 8.392887e-01 0.076 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.392887e-01 0.076 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.392887e-01 0.076 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.392887e-01 0.076 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.392887e-01 0.076 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.392887e-01 0.076 0 0
Repression of WNT target genes R-HSA-4641265 8.392887e-01 0.076 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.392887e-01 0.076 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.392887e-01 0.076 0 0
Regulation of IFNG signaling R-HSA-877312 8.392887e-01 0.076 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.392887e-01 0.076 0 0
Estrogen biosynthesis R-HSA-193144 8.392887e-01 0.076 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.428731e-01 0.074 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.430923e-01 0.074 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.430923e-01 0.074 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.430923e-01 0.074 0 0
Syndecan interactions R-HSA-3000170 8.430923e-01 0.074 0 0
DAP12 interactions R-HSA-2172127 8.436621e-01 0.074 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.452548e-01 0.073 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.462587e-01 0.072 0 0
Nuclear import of Rev protein R-HSA-180746 8.462587e-01 0.072 0 0
Signaling by NOTCH2 R-HSA-1980145 8.462587e-01 0.072 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.462587e-01 0.072 0 0
PTEN Regulation R-HSA-6807070 8.490207e-01 0.071 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.491233e-01 0.071 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.491233e-01 0.071 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.493923e-01 0.071 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.526172e-01 0.069 0 0
Eukaryotic Translation Termination R-HSA-72764 8.526172e-01 0.069 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.538762e-01 0.069 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.538762e-01 0.069 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.538762e-01 0.069 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.538762e-01 0.069 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.538981e-01 0.069 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.538981e-01 0.069 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.538981e-01 0.069 0 0
DNA Repair R-HSA-73894 8.562674e-01 0.067 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.563405e-01 0.067 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.563405e-01 0.067 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.563405e-01 0.067 0 0
Complex III assembly R-HSA-9865881 8.563405e-01 0.067 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.566498e-01 0.067 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.566498e-01 0.067 0 0
Formation of axial mesoderm R-HSA-9796292 8.566498e-01 0.067 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.566498e-01 0.067 0 0
Chylomicron remodeling R-HSA-8963901 8.566498e-01 0.067 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.566498e-01 0.067 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.566498e-01 0.067 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.566498e-01 0.067 0 0
Processing of SMDT1 R-HSA-8949664 8.566498e-01 0.067 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.566498e-01 0.067 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.566498e-01 0.067 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.574751e-01 0.067 0 0
Nucleotide Excision Repair R-HSA-5696398 8.577071e-01 0.067 0 0
Influenza Infection R-HSA-168255 8.621864e-01 0.064 0 0
HIV Infection R-HSA-162906 8.622431e-01 0.064 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.635175e-01 0.064 0 0
Signaling by TGFBR3 R-HSA-9839373 8.635175e-01 0.064 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.679679e-01 0.061 0 0
RNA Polymerase III Transcription R-HSA-74158 8.679679e-01 0.061 0 0
Laminin interactions R-HSA-3000157 8.685586e-01 0.061 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.706568e-01 0.060 0 0
Interleukin-1 family signaling R-HSA-446652 8.717054e-01 0.060 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.718170e-01 0.060 0 0
The activation of arylsulfatases R-HSA-1663150 8.721364e-01 0.059 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.721364e-01 0.059 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.721364e-01 0.059 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.721364e-01 0.059 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.721364e-01 0.059 0 0
Physiological factors R-HSA-5578768 8.721364e-01 0.059 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.721364e-01 0.059 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.721364e-01 0.059 0 0
Malate-aspartate shuttle R-HSA-9856872 8.721364e-01 0.059 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.721364e-01 0.059 0 0
P2Y receptors R-HSA-417957 8.721364e-01 0.059 0 0
Zinc transporters R-HSA-435354 8.721364e-01 0.059 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.726085e-01 0.059 0 0
Signaling by FGFR R-HSA-190236 8.730418e-01 0.059 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.736529e-01 0.059 0 0
Signaling by FGFR2 R-HSA-5654738 8.736529e-01 0.059 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.798145e-01 0.056 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.798145e-01 0.056 0 0
Sphingolipid catabolism R-HSA-9845614 8.798145e-01 0.056 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.798145e-01 0.056 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.798145e-01 0.056 0 0
Mitochondrial biogenesis R-HSA-1592230 8.805991e-01 0.055 0 0
Metal ion SLC transporters R-HSA-425410 8.811718e-01 0.055 0 0
Parasitic Infection Pathways R-HSA-9824443 8.843969e-01 0.053 0 0
Leishmania infection R-HSA-9658195 8.843969e-01 0.053 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.859508e-01 0.053 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.859508e-01 0.053 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.859508e-01 0.053 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.859508e-01 0.053 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.859508e-01 0.053 0 0
Translesion synthesis by REV1 R-HSA-110312 8.859508e-01 0.053 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.859508e-01 0.053 0 0
Protein lipoylation R-HSA-9857492 8.859508e-01 0.053 0 0
Signaling by Activin R-HSA-1502540 8.859508e-01 0.053 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.859508e-01 0.053 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.859508e-01 0.053 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.859508e-01 0.053 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.859508e-01 0.053 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.862319e-01 0.052 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.862319e-01 0.052 0 0
GABA receptor activation R-HSA-977443 8.866597e-01 0.052 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.869253e-01 0.052 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.871218e-01 0.052 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.882830e-01 0.051 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.882830e-01 0.051 0 0
Gap junction trafficking and regulation R-HSA-157858 8.892302e-01 0.051 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.901735e-01 0.051 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.901735e-01 0.051 0 0
Insulin processing R-HSA-264876 8.901735e-01 0.051 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.904936e-01 0.050 0 0
Aquaporin-mediated transport R-HSA-445717 8.937913e-01 0.049 0 0
MAP kinase activation R-HSA-450294 8.937913e-01 0.049 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.968063e-01 0.047 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.982734e-01 0.047 0 0
Translesion synthesis by POLI R-HSA-5656121 8.982734e-01 0.047 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.982734e-01 0.047 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.982734e-01 0.047 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.982734e-01 0.047 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.982734e-01 0.047 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.982734e-01 0.047 0 0
Differentiation of T cells R-HSA-9945266 8.982734e-01 0.047 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.982734e-01 0.047 0 0
Fructose catabolism R-HSA-70350 8.982734e-01 0.047 0 0
Negative regulation of FLT3 R-HSA-9706369 8.982734e-01 0.047 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.982734e-01 0.047 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 8.982734e-01 0.047 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.982734e-01 0.047 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.982734e-01 0.047 0 0
Atorvastatin ADME R-HSA-9754706 8.982734e-01 0.047 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.993647e-01 0.046 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.993647e-01 0.046 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.996978e-01 0.046 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.996978e-01 0.046 0 0
Pyroptosis R-HSA-5620971 8.996978e-01 0.046 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.003463e-01 0.046 0 0
Viral mRNA Translation R-HSA-192823 9.019184e-01 0.045 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.034110e-01 0.044 0 0
Glycogen metabolism R-HSA-8982491 9.034110e-01 0.044 0 0
Meiotic recombination R-HSA-912446 9.039224e-01 0.044 0 0
Signaling by NOTCH4 R-HSA-9013694 9.052950e-01 0.043 0 0
Ion channel transport R-HSA-983712 9.064565e-01 0.043 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.068973e-01 0.042 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.069791e-01 0.042 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.084469e-01 0.042 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.084469e-01 0.042 0 0
Translesion synthesis by POLK R-HSA-5655862 9.092652e-01 0.041 0 0
Glycine degradation R-HSA-6783984 9.092652e-01 0.041 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.092652e-01 0.041 0 0
Passive transport by Aquaporins R-HSA-432047 9.092652e-01 0.041 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.092652e-01 0.041 0 0
Coenzyme A biosynthesis R-HSA-196783 9.092652e-01 0.041 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.092652e-01 0.041 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.092652e-01 0.041 0 0
Potential therapeutics for SARS R-HSA-9679191 9.095876e-01 0.041 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.106300e-01 0.041 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.108111e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.108111e-01 0.041 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.108111e-01 0.041 0 0
RSV-host interactions R-HSA-9833110 9.118176e-01 0.040 0 0
Host Interactions of HIV factors R-HSA-162909 9.149625e-01 0.039 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.164158e-01 0.038 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.164409e-01 0.038 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.164771e-01 0.038 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.164771e-01 0.038 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.164771e-01 0.038 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.164771e-01 0.038 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.168624e-01 0.038 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.176925e-01 0.037 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.176925e-01 0.037 0 0
Cellular response to hypoxia R-HSA-1234174 9.185671e-01 0.037 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.190699e-01 0.037 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.190699e-01 0.037 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.190699e-01 0.037 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.190699e-01 0.037 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.190699e-01 0.037 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.190699e-01 0.037 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.190699e-01 0.037 0 0
Potassium Channels R-HSA-1296071 9.203519e-01 0.036 0 0
Neutrophil degranulation R-HSA-6798695 9.205542e-01 0.036 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.208559e-01 0.036 0 0
Translation of Structural Proteins R-HSA-9694635 9.215366e-01 0.035 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.227290e-01 0.035 0 0
Budding and maturation of HIV virion R-HSA-162588 9.238416e-01 0.034 0 0
Cargo concentration in the ER R-HSA-5694530 9.238416e-01 0.034 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.238416e-01 0.034 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.238416e-01 0.034 0 0
Activation of GABAB receptors R-HSA-991365 9.240860e-01 0.034 0 0
GABA B receptor activation R-HSA-977444 9.240860e-01 0.034 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.247769e-01 0.034 0 0
RNA Polymerase I Transcription R-HSA-73864 9.263805e-01 0.033 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.278156e-01 0.033 0 0
Apoptotic factor-mediated response R-HSA-111471 9.278156e-01 0.033 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.278156e-01 0.033 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.278156e-01 0.033 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.278156e-01 0.033 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.278156e-01 0.033 0 0
Nephron development R-HSA-9831926 9.278156e-01 0.033 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.278156e-01 0.033 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.282209e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.286710e-01 0.032 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.300213e-01 0.032 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.305903e-01 0.031 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.305903e-01 0.031 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.350473e-01 0.029 0 0
Signaling by WNT R-HSA-195721 9.351008e-01 0.029 0 0
Signaling by MET R-HSA-6806834 9.352843e-01 0.029 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.355268e-01 0.029 0 0
Surfactant metabolism R-HSA-5683826 9.355268e-01 0.029 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.355268e-01 0.029 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.356167e-01 0.029 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.356167e-01 0.029 0 0
Translesion Synthesis by POLH R-HSA-110320 9.356167e-01 0.029 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.356167e-01 0.029 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.356167e-01 0.029 0 0
Regulation of signaling by CBL R-HSA-912631 9.356167e-01 0.029 0 0
Diseases of hemostasis R-HSA-9671793 9.356167e-01 0.029 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.356167e-01 0.029 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.356167e-01 0.029 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.367704e-01 0.028 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.367704e-01 0.028 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.406299e-01 0.027 0 0
GPCR downstream signalling R-HSA-388396 9.409280e-01 0.026 0 0
Interleukin-17 signaling R-HSA-448424 9.422663e-01 0.026 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.424259e-01 0.026 0 0
Heme degradation R-HSA-189483 9.424259e-01 0.026 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.424259e-01 0.026 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.425751e-01 0.026 0 0
Formation of definitive endoderm R-HSA-9823730 9.425751e-01 0.026 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.425751e-01 0.026 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.425751e-01 0.026 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.425751e-01 0.026 0 0
Pregnenolone biosynthesis R-HSA-196108 9.425751e-01 0.026 0 0
Signal transduction by L1 R-HSA-445144 9.425751e-01 0.026 0 0
Dual incision in TC-NER R-HSA-6782135 9.426446e-01 0.026 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.426446e-01 0.026 0 0
Toll-like Receptor Cascades R-HSA-168898 9.444990e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.453565e-01 0.024 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.468306e-01 0.024 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.468306e-01 0.024 0 0
Dual Incision in GG-NER R-HSA-5696400 9.475980e-01 0.023 0 0
eNOS activation R-HSA-203615 9.475980e-01 0.023 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.475980e-01 0.023 0 0
G-protein activation R-HSA-202040 9.487818e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.487818e-01 0.023 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.487818e-01 0.023 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.487818e-01 0.023 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.487818e-01 0.023 0 0
Phenylalanine metabolism R-HSA-8964208 9.487818e-01 0.023 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.487818e-01 0.023 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.487818e-01 0.023 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.497312e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.507350e-01 0.022 1 1
Mitochondrial protein degradation R-HSA-9837999 9.514606e-01 0.022 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.517971e-01 0.021 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.517971e-01 0.021 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.522430e-01 0.021 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.523250e-01 0.021 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.523250e-01 0.021 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.523250e-01 0.021 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.523250e-01 0.021 0 0
Protein localization R-HSA-9609507 9.527029e-01 0.021 0 0
Ca2+ pathway R-HSA-4086398 9.533056e-01 0.021 0 0
Intraflagellar transport R-HSA-5620924 9.537775e-01 0.021 0 0
Gluconeogenesis R-HSA-70263 9.537775e-01 0.021 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.543180e-01 0.020 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.543180e-01 0.020 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.543180e-01 0.020 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.543180e-01 0.020 0 0
Assembly Of The HIV Virion R-HSA-175474 9.543180e-01 0.020 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.543742e-01 0.020 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.566428e-01 0.019 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.566428e-01 0.019 0 0
Triglyceride catabolism R-HSA-163560 9.566428e-01 0.019 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.566428e-01 0.019 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.572996e-01 0.019 0 0
tRNA processing in the nucleus R-HSA-6784531 9.577642e-01 0.019 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.592561e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.592561e-01 0.018 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.592561e-01 0.018 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.592561e-01 0.018 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.592561e-01 0.018 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.592561e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.592561e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.592561e-01 0.018 0 0
mTORC1-mediated signalling R-HSA-166208 9.592561e-01 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.592561e-01 0.018 0 0
Cellular hexose transport R-HSA-189200 9.592561e-01 0.018 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.593776e-01 0.018 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.595582e-01 0.018 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.605845e-01 0.017 0 0
Voltage gated Potassium channels R-HSA-1296072 9.605845e-01 0.017 0 0
Degradation of DVL R-HSA-4641258 9.605845e-01 0.017 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.609074e-01 0.017 0 0
Signaling by NOTCH R-HSA-157118 9.615356e-01 0.017 0 0
Cellular response to starvation R-HSA-9711097 9.634576e-01 0.016 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.636606e-01 0.016 0 0
Carnitine shuttle R-HSA-200425 9.636606e-01 0.016 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.636606e-01 0.016 0 0
Formation of the ureteric bud R-HSA-9830674 9.636606e-01 0.016 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.636606e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.636606e-01 0.016 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.636606e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.641618e-01 0.016 0 0
Diseases of programmed cell death R-HSA-9645723 9.645767e-01 0.016 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.672316e-01 0.014 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.674608e-01 0.014 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.674608e-01 0.014 0 0
Cholesterol biosynthesis R-HSA-191273 9.675087e-01 0.014 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.675892e-01 0.014 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.675892e-01 0.014 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.675892e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.675892e-01 0.014 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.675892e-01 0.014 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.675892e-01 0.014 0 0
Base Excision Repair R-HSA-73884 9.691607e-01 0.014 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.698179e-01 0.013 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.704504e-01 0.013 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.704504e-01 0.013 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.704504e-01 0.013 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.704504e-01 0.013 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.710934e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.710934e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.710934e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.710934e-01 0.013 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.710934e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.710934e-01 0.013 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.710934e-01 0.013 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.710934e-01 0.013 0 0
Interleukin-1 signaling R-HSA-9020702 9.711558e-01 0.013 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.714784e-01 0.013 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.731741e-01 0.012 0 0
IRE1alpha activates chaperones R-HSA-381070 9.731938e-01 0.012 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.736259e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.742188e-01 0.011 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.742188e-01 0.011 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.742188e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.742188e-01 0.011 0 0
Myogenesis R-HSA-525793 9.742188e-01 0.011 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.745314e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.750224e-01 0.011 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.756545e-01 0.011 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.756545e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.764513e-01 0.010 0 0
Cell-cell junction organization R-HSA-421270 9.764793e-01 0.010 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.767423e-01 0.010 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.770065e-01 0.010 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.770065e-01 0.010 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.770065e-01 0.010 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.770065e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.770065e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.770065e-01 0.010 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.770065e-01 0.010 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.775752e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.776237e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.789763e-01 0.009 0 0
Metabolism of cofactors R-HSA-8978934 9.793187e-01 0.009 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.794929e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.794929e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.794929e-01 0.009 0 0
Pyrimidine salvage R-HSA-73614 9.794929e-01 0.009 0 0
Defensins R-HSA-1461973 9.799667e-01 0.009 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.799667e-01 0.009 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.801442e-01 0.009 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.805995e-01 0.009 0 0
Platelet degranulation R-HSA-114608 9.808626e-01 0.008 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.813643e-01 0.008 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.817106e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.817106e-01 0.008 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.817106e-01 0.008 0 0
DNA methylation R-HSA-5334118 9.817106e-01 0.008 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.817106e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.817106e-01 0.008 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.817106e-01 0.008 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.817106e-01 0.008 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.818352e-01 0.008 0 0
Gap junction trafficking R-HSA-190828 9.818352e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.821376e-01 0.008 0 0
Regulation of beta-cell development R-HSA-186712 9.821376e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.829538e-01 0.007 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.835341e-01 0.007 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.836533e-01 0.007 0 0
Mucopolysaccharidoses R-HSA-2206281 9.836885e-01 0.007 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.843915e-01 0.007 0 0
Iron uptake and transport R-HSA-917937 9.850927e-01 0.007 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.850927e-01 0.007 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.850927e-01 0.007 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.854527e-01 0.006 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.854527e-01 0.006 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.854527e-01 0.006 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.856282e-01 0.006 0 0
Adherens junctions interactions R-HSA-418990 9.857816e-01 0.006 0 0
Selenoamino acid metabolism R-HSA-2408522 9.859932e-01 0.006 0 0
Chromosome Maintenance R-HSA-73886 9.861654e-01 0.006 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.863234e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.870261e-01 0.006 0 0
G alpha (q) signalling events R-HSA-416476 9.873064e-01 0.006 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.878145e-01 0.005 0 0
Downstream TCR signaling R-HSA-202424 9.879147e-01 0.005 0 0
PCP/CE pathway R-HSA-4086400 9.883804e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.884295e-01 0.005 0 0
Degradation of CDH1 R-HSA-9766229 9.889113e-01 0.005 0 0
Signaling by GPCR R-HSA-372790 9.893916e-01 0.005 0 0
CS/DS degradation R-HSA-2024101 9.896811e-01 0.005 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.896811e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.904608e-01 0.004 0 0
Adaptive Immune System R-HSA-1280218 9.905230e-01 0.004 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.906471e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.907974e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.907974e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.907974e-01 0.004 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.907974e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.907974e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.907974e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.909136e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.911597e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.912907e-01 0.004 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.917776e-01 0.004 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.917776e-01 0.004 0 0
Orc1 removal from chromatin R-HSA-68949 9.917776e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.917930e-01 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.917930e-01 0.004 0 0
PERK regulates gene expression R-HSA-381042 9.917930e-01 0.004 0 0
Ribosome-associated quality control R-HSA-9948299 9.918201e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.918654e-01 0.004 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.925610e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.926809e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.926809e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.928540e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.928540e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.928540e-01 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.932163e-01 0.003 0 0
Translation initiation complex formation R-HSA-72649 9.932713e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.932713e-01 0.003 0 0
rRNA processing R-HSA-72312 9.933074e-01 0.003 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.933236e-01 0.003 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.933795e-01 0.003 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.934728e-01 0.003 0 0
Cleavage of the damaged purine R-HSA-110331 9.934728e-01 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.934728e-01 0.003 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.934728e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.934728e-01 0.003 0 0
Hemostasis R-HSA-109582 9.935599e-01 0.003 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.939150e-01 0.003 0 0
G alpha (z) signalling events R-HSA-418597 9.939150e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.939611e-01 0.003 0 0
Depurination R-HSA-73927 9.941791e-01 0.003 0 0
Circadian clock R-HSA-9909396 9.943881e-01 0.002 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.944930e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.944930e-01 0.002 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.944982e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.944982e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.945891e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.948090e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.948090e-01 0.002 0 0
Stabilization of p53 R-HSA-69541 9.948090e-01 0.002 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.949794e-01 0.002 0 0
Regulation of CDH1 Function R-HSA-9764561 9.950265e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.950265e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.950367e-01 0.002 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.951588e-01 0.002 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.953707e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.953707e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.953707e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.953847e-01 0.002 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.955049e-01 0.002 0 0
tRNA processing R-HSA-72306 9.956733e-01 0.002 0 0
Protein ubiquitination R-HSA-8852135 9.958301e-01 0.002 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.958717e-01 0.002 0 0
Extension of Telomeres R-HSA-180786 9.959380e-01 0.002 0 0
HCMV Early Events R-HSA-9609690 9.961680e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.961755e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.963301e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.963623e-01 0.002 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.964956e-01 0.002 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.966849e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.967170e-01 0.001 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.967170e-01 0.001 0 0
Depyrimidination R-HSA-73928 9.967170e-01 0.001 0 0
MTOR signalling R-HSA-165159 9.967170e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.968493e-01 0.001 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.970060e-01 0.001 0 0
Protein folding R-HSA-391251 9.970598e-01 0.001 0 0
Defective pyroptosis R-HSA-9710421 9.970724e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.970724e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.972964e-01 0.001 0 0
DNA Replication R-HSA-69306 9.973052e-01 0.001 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.973079e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.975432e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.975432e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.975446e-01 0.001 0 0
Synthesis of DNA R-HSA-69239 9.976239e-01 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.976719e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.976719e-01 0.001 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.979240e-01 0.001 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.979240e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.979240e-01 0.001 0 0
Vesicle-mediated transport R-HSA-5653656 9.980264e-01 0.001 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.981487e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.981487e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.981487e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.982052e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.983492e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.983806e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.984125e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.984212e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.984400e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.984993e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.984993e-01 0.001 0 0
DNA Damage Bypass R-HSA-73893 9.985279e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.985279e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.985279e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.986821e-01 0.001 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.986821e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.987954e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.988114e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.988114e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.988295e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.988295e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.988295e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.988295e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.988614e-01 0.000 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.988946e-01 0.000 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.989563e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.989925e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991287e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991468e-01 0.000 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.991701e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.992600e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.992600e-01 0.000 0 0
UCH proteinases R-HSA-5689603 9.992921e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.993402e-01 0.000 0 0
Digestion R-HSA-8935690 9.993402e-01 0.000 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.993820e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.994116e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.994181e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.994251e-01 0.000 0 0
Co-inhibition by PD-1 R-HSA-389948 9.994535e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994820e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.994820e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.995270e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.995322e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.995585e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995789e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995797e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.995829e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.995829e-01 0.000 0 0
Telomere Maintenance R-HSA-157579 9.996181e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996281e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996281e-01 0.000 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.996331e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996537e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997043e-01 0.000 0 0
Neddylation R-HSA-8951664 9.997144e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997364e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.997364e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997471e-01 0.000 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.997511e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.997650e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.997733e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.997760e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997865e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.998185e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998262e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998334e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.998676e-01 0.000 0 0
Gene Silencing by RNA R-HSA-211000 9.998709e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998819e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.998879e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999061e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999216e-01 0.000 0 0
Immune System R-HSA-168256 9.999330e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999363e-01 0.000 1 0
Mitochondrial translation elongation R-HSA-5389840 9.999370e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999454e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999471e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.999471e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999525e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999542e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999582e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999595e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999625e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.999625e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999687e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999701e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999741e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999766e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999788e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999812e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999813e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999832e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.999840e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999859e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999873e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999892e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999924e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999924e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999925e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999940e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999947e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999966e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999975e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999980e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999984e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999990e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999993e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999995e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999996e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 2.739037e-10 9.562 0 0
Apoptotic execution phase R-HSA-75153 3.407179e-10 9.468 0 0
Cell Cycle R-HSA-1640170 1.167160e-09 8.933 0 0
Mitotic Prometaphase R-HSA-68877 1.154390e-07 6.938 0 0
M Phase R-HSA-68886 1.691522e-07 6.772 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.764752e-07 6.558 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.113218e-07 6.507 0 0
Signal Transduction R-HSA-162582 2.938607e-07 6.532 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.143652e-07 6.289 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.143652e-07 6.289 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.722027e-07 6.172 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.989066e-07 6.098 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.709302e-07 6.013 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.619701e-06 5.791 0 0
Cell-Cell communication R-HSA-1500931 3.757219e-06 5.425 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.386161e-06 5.358 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.440219e-06 5.353 0 0
Nervous system development R-HSA-9675108 8.211444e-06 5.086 0 0
Interleukin-12 signaling R-HSA-9020591 1.015170e-05 4.993 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.505028e-05 4.822 0 0
Axon guidance R-HSA-422475 1.523693e-05 4.817 0 0
Mitotic Anaphase R-HSA-68882 2.089024e-05 4.680 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.290744e-05 4.640 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.744607e-05 4.562 0 0
Separation of Sister Chromatids R-HSA-2467813 3.024364e-05 4.519 0 0
Cellular responses to stimuli R-HSA-8953897 3.765168e-05 4.424 0 0
Cell Cycle Checkpoints R-HSA-69620 4.077899e-05 4.390 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.579699e-05 4.253 0 0
Apoptosis R-HSA-109581 5.686815e-05 4.245 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.069476e-05 4.217 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.047439e-05 4.218 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.401070e-05 4.194 0 0
Interleukin-12 family signaling R-HSA-447115 6.762153e-05 4.170 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.818660e-05 4.166 0 0
Cellular response to heat stress R-HSA-3371556 7.903769e-05 4.102 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.921512e-05 4.003 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.162981e-04 3.934 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.191427e-04 3.924 0 0
Signaling by ROBO receptors R-HSA-376176 1.241262e-04 3.906 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.328783e-04 3.877 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.474473e-04 3.831 0 0
mRNA Splicing R-HSA-72172 1.470637e-04 3.832 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.474473e-04 3.831 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.567093e-04 3.805 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.811628e-04 3.742 0 0
Metabolism of RNA R-HSA-8953854 1.919910e-04 3.717 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.724647e-04 3.565 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.386422e-04 3.470 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.386422e-04 3.470 0 0
Cell junction organization R-HSA-446728 3.492273e-04 3.457 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.576335e-04 3.447 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.009207e-04 3.397 0 0
Mitotic Prophase R-HSA-68875 4.093283e-04 3.388 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.711486e-04 3.327 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.711486e-04 3.327 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.720590e-04 3.326 0 0
Cellular responses to stress R-HSA-2262752 5.186899e-04 3.285 0 0
Signaling by Hippo R-HSA-2028269 5.503080e-04 3.259 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.788781e-04 3.237 0 0
Chromatin organization R-HSA-4839726 5.876963e-04 3.231 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.762259e-04 3.239 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.338944e-04 3.198 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.338944e-04 3.198 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.338944e-04 3.198 0 0
Influenza Infection R-HSA-168255 6.234123e-04 3.205 0 0
Programmed Cell Death R-HSA-5357801 6.434741e-04 3.191 0 0
Nuclear import of Rev protein R-HSA-180746 7.064039e-04 3.151 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.793524e-04 3.108 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.793524e-04 3.108 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.853064e-04 3.105 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.853064e-04 3.105 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.033551e-04 3.044 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.929944e-04 3.049 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.794462e-04 3.056 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.206687e-04 3.036 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.386472e-04 3.027 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.719428e-04 3.012 0 0
EPH-Ephrin signaling R-HSA-2682334 9.992692e-04 3.000 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.961072e-04 3.002 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.088191e-03 2.963 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.070309e-03 2.970 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.116720e-03 2.952 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.148912e-03 2.940 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.148912e-03 2.940 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.236130e-03 2.908 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.236130e-03 2.908 0 0
Chromatin modifying enzymes R-HSA-3247509 1.367383e-03 2.864 0 0
Peptide chain elongation R-HSA-156902 1.393002e-03 2.856 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.472389e-03 2.832 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.684935e-03 2.773 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.708496e-03 2.767 0 0
Cellular response to starvation R-HSA-9711097 1.784631e-03 2.748 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.803046e-03 2.744 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.014977e-03 2.696 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.014977e-03 2.696 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.014977e-03 2.696 0 0
Signaling by RAS mutants R-HSA-6802949 2.014977e-03 2.696 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.020286e-03 2.695 0 0
Membrane Trafficking R-HSA-199991 2.054604e-03 2.687 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.199112e-03 2.658 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.429404e-03 2.615 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.449476e-03 2.611 0 0
Signaling by ALK in cancer R-HSA-9700206 2.449476e-03 2.611 0 0
HDACs deacetylate histones R-HSA-3214815 2.529055e-03 2.597 0 0
Cellular Senescence R-HSA-2559583 2.579170e-03 2.589 0 0
MAP2K and MAPK activation R-HSA-5674135 2.815100e-03 2.551 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.079574e-03 2.512 0 0
Ephrin signaling R-HSA-3928664 3.224116e-03 2.492 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.224116e-03 2.492 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.224116e-03 2.492 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.356045e-03 2.474 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.399410e-03 2.469 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.524354e-03 2.453 0 0
Eukaryotic Translation Termination R-HSA-72764 3.524354e-03 2.453 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.034595e-03 2.394 0 0
Regulation of KIT signaling R-HSA-1433559 4.034595e-03 2.394 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.951477e-03 2.403 0 0
HSF1-dependent transactivation R-HSA-3371571 4.058634e-03 2.392 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.361493e-03 2.360 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.436982e-03 2.353 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.509071e-03 2.346 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.524927e-03 2.344 0 0
mRNA 3'-end processing R-HSA-72187 4.619173e-03 2.335 0 0
G0 and Early G1 R-HSA-1538133 4.680564e-03 2.330 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.680564e-03 2.330 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.743134e-03 2.324 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.332578e-03 2.273 0 0
Nephrin family interactions R-HSA-373753 5.034841e-03 2.298 0 0
Adherens junctions interactions R-HSA-418990 5.216393e-03 2.283 0 0
Death Receptor Signaling R-HSA-73887 5.032514e-03 2.298 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.324245e-03 2.274 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.510150e-03 2.259 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.735247e-03 2.241 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.735247e-03 2.241 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.838410e-03 2.234 0 0
Striated Muscle Contraction R-HSA-390522 6.449005e-03 2.191 0 0
Cell-cell junction organization R-HSA-421270 6.555042e-03 2.183 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.686891e-03 2.175 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.686891e-03 2.175 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.032370e-03 2.153 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.067877e-03 2.151 0 0
Gene expression (Transcription) R-HSA-74160 7.121879e-03 2.147 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.296816e-03 2.137 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.931277e-03 2.101 0 0
NRAGE signals death through JNK R-HSA-193648 7.508098e-03 2.124 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.073206e-03 2.093 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.073206e-03 2.093 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.382839e-03 2.077 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.391221e-03 2.076 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.403542e-03 2.076 0 0
Regulation of CDH1 Function R-HSA-9764561 8.414900e-03 2.075 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.111363e-03 2.040 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.215123e-03 2.035 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.405028e-03 2.027 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.729384e-03 2.012 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.729384e-03 2.012 0 0
Centrosome maturation R-HSA-380287 9.821506e-03 2.008 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.026033e-02 1.989 0 0
snRNP Assembly R-HSA-191859 1.048337e-02 1.979 0 0
Metabolism of non-coding RNA R-HSA-194441 1.048337e-02 1.979 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.080046e-02 1.967 0 0
Kinesins R-HSA-983189 1.165485e-02 1.933 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.086684e-02 1.964 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.081254e-02 1.966 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.198032e-02 1.922 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.198032e-02 1.922 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.198032e-02 1.922 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.198032e-02 1.922 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.198032e-02 1.922 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.198032e-02 1.922 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.251868e-02 1.902 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.251868e-02 1.902 0 0
Selenocysteine synthesis R-HSA-2408557 1.258967e-02 1.900 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.292446e-02 1.889 0 0
RNA Polymerase I Transcription R-HSA-73864 1.298589e-02 1.887 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.313211e-02 1.882 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.368411e-02 1.864 0 0
Viral mRNA Translation R-HSA-192823 1.468828e-02 1.833 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.504283e-02 1.823 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.504283e-02 1.823 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.429717e-02 1.845 0 0
Rap1 signalling R-HSA-392517 1.513261e-02 1.820 0 0
Signaling by VEGF R-HSA-194138 1.326248e-02 1.877 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.335619e-02 1.874 0 0
tRNA processing in the nucleus R-HSA-6784531 1.429717e-02 1.845 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.515186e-02 1.820 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.500269e-02 1.824 0 0
Attenuation phase R-HSA-3371568 1.684368e-02 1.774 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.778244e-02 1.750 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.852412e-02 1.732 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.874254e-02 1.727 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.898415e-02 1.722 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.002105e-02 1.699 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.006126e-02 1.698 0 0
PTEN Regulation R-HSA-6807070 2.033166e-02 1.692 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.041720e-02 1.690 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.041720e-02 1.690 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.085002e-02 1.681 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.109514e-02 1.676 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.109514e-02 1.676 0 0
DCC mediated attractive signaling R-HSA-418885 2.109514e-02 1.676 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.109514e-02 1.676 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.300188e-02 1.638 0 0
Glycolysis R-HSA-70171 2.303954e-02 1.638 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.341571e-02 1.630 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.405295e-02 1.619 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.511013e-02 1.600 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.554727e-02 1.593 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.554727e-02 1.593 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.555229e-02 1.593 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.555229e-02 1.593 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.872487e-02 1.542 0 0
G1/S-Specific Transcription R-HSA-69205 2.710540e-02 1.567 0 0
HSF1 activation R-HSA-3371511 2.710540e-02 1.567 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.050941e-02 1.516 0 0
Notch-HLH transcription pathway R-HSA-350054 2.922413e-02 1.534 0 0
RUNX2 regulates bone development R-HSA-8941326 2.710540e-02 1.567 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.055936e-02 1.515 0 0
Response to metal ions R-HSA-5660526 3.055936e-02 1.515 0 0
Smooth Muscle Contraction R-HSA-445355 3.102040e-02 1.508 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.164158e-02 1.500 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.278714e-02 1.484 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.477042e-02 1.459 0 0
S Phase R-HSA-69242 3.584213e-02 1.446 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.598109e-02 1.444 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.598109e-02 1.444 0 0
ESR-mediated signaling R-HSA-8939211 3.626487e-02 1.441 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.646976e-02 1.438 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.307755e-02 1.366 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.307755e-02 1.366 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.307755e-02 1.366 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.307755e-02 1.366 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.855853e-02 1.414 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.855853e-02 1.414 0 0
Disorders of Nervous System Development R-HSA-9697154 4.377109e-02 1.359 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.377109e-02 1.359 0 0
Pervasive developmental disorders R-HSA-9005895 4.377109e-02 1.359 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.232691e-02 1.373 0 0
Signaling by EGFR R-HSA-177929 4.064655e-02 1.391 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.377109e-02 1.359 0 0
HDMs demethylate histones R-HSA-3214842 4.412833e-02 1.355 0 0
Recycling pathway of L1 R-HSA-437239 3.974115e-02 1.401 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.917810e-02 1.407 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.364239e-02 1.360 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.960804e-02 1.402 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.198443e-02 1.377 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.198443e-02 1.377 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.371833e-02 1.359 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.687147e-02 1.433 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.403855e-02 1.356 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.371833e-02 1.359 0 0
Muscle contraction R-HSA-397014 4.634975e-02 1.334 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.640901e-02 1.333 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.832960e-02 1.316 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.861233e-02 1.313 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.871899e-02 1.312 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.987906e-02 1.302 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.987906e-02 1.302 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.987906e-02 1.302 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.998333e-02 1.301 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.243185e-02 1.280 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.243185e-02 1.280 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.243185e-02 1.280 0 0
Inositol phosphate metabolism R-HSA-1483249 5.284517e-02 1.277 0 0
G alpha (12/13) signalling events R-HSA-416482 5.414867e-02 1.266 0 0
RAF activation R-HSA-5673000 5.415553e-02 1.266 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.415553e-02 1.266 0 0
MTOR signalling R-HSA-165159 5.614512e-02 1.251 0 0
Signaling by ERBB2 R-HSA-1227986 5.640834e-02 1.249 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.648213e-02 1.248 0 0
Ribosome-associated quality control R-HSA-9948299 5.656159e-02 1.247 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.945808e-02 1.226 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.995626e-02 1.222 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.106888e-02 1.214 0 0
TBC/RABGAPs R-HSA-8854214 6.146488e-02 1.211 0 0
Signaling by SCF-KIT R-HSA-1433557 6.146488e-02 1.211 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 6.385295e-02 1.195 0 0
Type I hemidesmosome assembly R-HSA-446107 6.262440e-02 1.203 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.262440e-02 1.203 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.262440e-02 1.203 0 0
Lipophagy R-HSA-9613354 7.671492e-02 1.115 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.232438e-02 1.141 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.232438e-02 1.141 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.304244e-02 1.136 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.028447e-02 1.153 0 0
Nucleosome assembly R-HSA-774815 7.302145e-02 1.137 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.302145e-02 1.137 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.161679e-02 1.210 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.675905e-02 1.175 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.675905e-02 1.175 0 0
FOXO-mediated transcription R-HSA-9614085 7.264082e-02 1.139 0 0
p75NTR signals via NF-kB R-HSA-193639 7.232438e-02 1.141 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.671492e-02 1.115 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.303438e-02 1.136 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.028447e-02 1.153 0 0
Rab regulation of trafficking R-HSA-9007101 7.691032e-02 1.114 0 0
rRNA processing R-HSA-72312 6.764235e-02 1.170 0 0
Gene Silencing by RNA R-HSA-211000 6.919209e-02 1.160 0 0
Netrin-1 signaling R-HSA-373752 6.708972e-02 1.173 0 0
Vesicle-mediated transport R-HSA-5653656 7.400509e-02 1.131 0 0
MAPK family signaling cascades R-HSA-5683057 6.245323e-02 1.204 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.232438e-02 1.141 0 0
Host Interactions of HIV factors R-HSA-162909 6.593019e-02 1.181 0 0
Signal regulatory protein family interactions R-HSA-391160 6.195506e-02 1.208 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.708972e-02 1.173 0 0
Glucose metabolism R-HSA-70326 7.691032e-02 1.114 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.496847e-02 1.187 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.796649e-02 1.108 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.847598e-02 1.105 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.926090e-02 1.101 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.974589e-02 1.098 0 0
Developmental Biology R-HSA-1266738 8.178281e-02 1.087 0 0
mTORC1-mediated signalling R-HSA-166208 8.221266e-02 1.085 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.351633e-02 1.078 0 0
Negative regulation of FLT3 R-HSA-9706369 8.351633e-02 1.078 0 0
Autophagy R-HSA-9612973 8.470193e-02 1.072 0 0
EGFR downregulation R-HSA-182971 8.610199e-02 1.065 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 8.726125e-02 1.059 0 0
Regulation of gap junction activity R-HSA-191650 8.726125e-02 1.059 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 8.726125e-02 1.059 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 8.726125e-02 1.059 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 8.726125e-02 1.059 0 0
MTF1 activates gene expression R-HSA-5660489 8.726125e-02 1.059 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 8.726125e-02 1.059 0 0
HIV Life Cycle R-HSA-162587 8.833630e-02 1.054 0 0
Signaling by NOTCH1 R-HSA-1980143 8.865470e-02 1.052 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.205800e-02 1.036 0 0
Regulation of CDH11 function R-HSA-9762292 9.205800e-02 1.036 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.205800e-02 1.036 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.205800e-02 1.036 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.266167e-02 1.033 0 0
DNA strand elongation R-HSA-69190 9.468542e-02 1.024 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.520031e-02 1.021 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.550111e-02 1.020 0 0
Disorders of Developmental Biology R-HSA-9675151 9.550111e-02 1.020 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.550111e-02 1.020 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.901182e-02 1.004 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.003684e-01 0.998 0 0
Post NMDA receptor activation events R-HSA-438064 1.004532e-01 0.998 0 0
RNA Polymerase II Transcription R-HSA-73857 1.011928e-01 0.995 0 0
FLT3 Signaling R-HSA-9607240 1.024704e-01 0.989 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.031338e-01 0.987 0 0
Macroautophagy R-HSA-1632852 1.037052e-01 0.984 0 0
Integrin signaling R-HSA-354192 1.037093e-01 0.984 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.037093e-01 0.984 0 0
Nucleotide Excision Repair R-HSA-5696398 1.049230e-01 0.979 0 0
Selective autophagy R-HSA-9663891 1.060897e-01 0.974 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.082435e-01 0.966 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.127619e-01 0.948 0 0
IRS activation R-HSA-74713 1.127619e-01 0.948 0 0
G2 Phase R-HSA-68911 1.127619e-01 0.948 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.398830e-01 0.854 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.398830e-01 0.854 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.085519e-01 0.964 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.085519e-01 0.964 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.085519e-01 0.964 0 0
Activation of RAC1 R-HSA-428540 1.260887e-01 0.899 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.260887e-01 0.899 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.445576e-01 0.840 0 0
Polymerase switching R-HSA-69091 1.445576e-01 0.840 0 0
Leading Strand Synthesis R-HSA-69109 1.445576e-01 0.840 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.445576e-01 0.840 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.445576e-01 0.840 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.445576e-01 0.840 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.445576e-01 0.840 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.445576e-01 0.840 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.217035e-01 0.915 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.230388e-01 0.910 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.230388e-01 0.910 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.439950e-01 0.842 0 0
Translation initiation complex formation R-HSA-72649 1.400499e-01 0.854 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.364307e-01 0.865 0 0
G1 Phase R-HSA-69236 1.379406e-01 0.860 0 0
Cyclin D associated events in G1 R-HSA-69231 1.379406e-01 0.860 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.445576e-01 0.840 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.358376e-01 0.867 0 0
Repression of WNT target genes R-HSA-4641265 1.445576e-01 0.840 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.112081e-01 0.954 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.445576e-01 0.840 0 0
Semaphorin interactions R-HSA-373755 1.325768e-01 0.878 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.398830e-01 0.854 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.364307e-01 0.865 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.248380e-01 0.904 0 0
Signaling by MET R-HSA-6806834 1.120943e-01 0.950 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.398830e-01 0.854 0 0
G2/M Transition R-HSA-69275 1.236955e-01 0.908 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.183602e-01 0.927 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.398830e-01 0.854 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.400499e-01 0.854 0 0
RET signaling R-HSA-8853659 1.439950e-01 0.842 0 0
Metallothioneins bind metals R-HSA-5661231 1.445576e-01 0.840 0 0
L1CAM interactions R-HSA-373760 1.191424e-01 0.924 0 0
Interleukin-7 signaling R-HSA-1266695 1.131417e-01 0.946 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.101129e-01 0.958 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.101129e-01 0.958 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.101129e-01 0.958 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.101129e-01 0.958 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.101129e-01 0.958 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.462582e-01 0.835 0 0
Chromosome Maintenance R-HSA-73886 1.474296e-01 0.831 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.476377e-01 0.831 0 0
DAG and IP3 signaling R-HSA-1489509 1.476377e-01 0.831 0 0
Signaling by NOTCH3 R-HSA-9012852 1.489455e-01 0.827 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.505989e-01 0.822 0 0
Negative regulation of MET activity R-HSA-6807004 1.505989e-01 0.822 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.507978e-01 0.822 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.507978e-01 0.822 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.507978e-01 0.822 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.507978e-01 0.822 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.507978e-01 0.822 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.507978e-01 0.822 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.543275e-01 0.812 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.543275e-01 0.812 0 0
Adipogenesis R-HSA-9843745 1.555609e-01 0.808 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.572410e-01 0.803 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.576468e-01 0.802 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.581081e-01 0.801 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.581081e-01 0.801 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.607607e-01 0.794 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.609243e-01 0.793 0 0
Late endosomal microautophagy R-HSA-9615710 1.616422e-01 0.791 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.638463e-01 0.786 0 0
Frs2-mediated activation R-HSA-170968 1.638463e-01 0.786 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.638463e-01 0.786 0 0
DNA Double Strand Break Response R-HSA-5693606 1.659260e-01 0.780 0 0
Lagging Strand Synthesis R-HSA-69186 1.659383e-01 0.780 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.659383e-01 0.780 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.659383e-01 0.780 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.659383e-01 0.780 0 0
MET promotes cell motility R-HSA-8875878 1.664581e-01 0.779 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.682135e-01 0.774 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.682135e-01 0.774 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.682135e-01 0.774 0 0
Selenoamino acid metabolism R-HSA-2408522 1.705020e-01 0.768 0 0
HCMV Early Events R-HSA-9609690 1.711270e-01 0.767 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.174477e-01 0.663 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.174477e-01 0.663 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.174477e-01 0.663 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.174477e-01 0.663 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.174477e-01 0.663 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.973970e-01 0.705 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.973970e-01 0.705 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.973970e-01 0.705 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.973970e-01 0.705 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.973970e-01 0.705 0 0
SOS-mediated signalling R-HSA-112412 1.973970e-01 0.705 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.271255e-01 0.644 0 0
Formation of annular gap junctions R-HSA-196025 2.271255e-01 0.644 0 0
Removal of the Flap Intermediate R-HSA-69166 1.838435e-01 0.736 0 0
Gap junction degradation R-HSA-190873 2.571340e-01 0.590 0 0
WNT mediated activation of DVL R-HSA-201688 2.571340e-01 0.590 0 0
ALK mutants bind TKIs R-HSA-9700645 2.571340e-01 0.590 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.044398e-01 0.689 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.044398e-01 0.689 0 0
Phosphorylation of the APC/C R-HSA-176412 2.255295e-01 0.647 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.255295e-01 0.647 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.818048e-01 0.740 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.470107e-01 0.607 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.749018e-01 0.757 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.320461e-01 0.634 0 0
Dual Incision in GG-NER R-HSA-5696400 2.465419e-01 0.608 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.282553e-01 0.642 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.839516e-01 0.735 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.353683e-01 0.628 0 0
Meiotic synapsis R-HSA-1221632 2.353683e-01 0.628 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.749018e-01 0.757 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.320461e-01 0.634 0 0
Activation of the pre-replicative complex R-HSA-68962 1.749018e-01 0.757 0 0
Generation of second messenger molecules R-HSA-202433 1.902886e-01 0.721 0 0
TGFBR3 expression R-HSA-9839394 2.494988e-01 0.603 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.749018e-01 0.757 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.026685e-01 0.693 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.028009e-01 0.693 0 0
G1/S Transition R-HSA-69206 1.790402e-01 0.747 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.973970e-01 0.705 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.818048e-01 0.740 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.324732e-01 0.634 0 0
Long-term potentiation R-HSA-9620244 2.494988e-01 0.603 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.496566e-01 0.603 0 0
Prolonged ERK activation events R-HSA-169893 2.255295e-01 0.647 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.838435e-01 0.736 0 0
Calcineurin activates NFAT R-HSA-2025928 2.571340e-01 0.590 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.316060e-01 0.635 0 0
Defective pyroptosis R-HSA-9710421 2.414195e-01 0.617 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.153312e-01 0.667 0 0
Signaling by WNT R-HSA-195721 1.837432e-01 0.736 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.422781e-01 0.616 0 0
PLC beta mediated events R-HSA-112043 2.076097e-01 0.683 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.470107e-01 0.607 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.026685e-01 0.693 0 0
Ca-dependent events R-HSA-111996 2.282553e-01 0.642 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.149113e-01 0.668 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.197134e-01 0.658 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.169422e-01 0.664 0 0
HIV Infection R-HSA-162906 2.236050e-01 0.651 0 0
Unwinding of DNA R-HSA-176974 2.571340e-01 0.590 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.571340e-01 0.590 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.818048e-01 0.740 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.771999e-01 0.752 0 0
RMTs methylate histone arginines R-HSA-3214858 2.548018e-01 0.594 0 0
Activation of BH3-only proteins R-HSA-114452 1.749018e-01 0.757 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.749989e-01 0.757 0 0
Signaling by PTK6 R-HSA-8848021 2.289404e-01 0.640 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.289404e-01 0.640 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.125140e-01 0.673 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.571340e-01 0.590 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.889337e-01 0.724 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.347124e-01 0.629 0 0
Protein methylation R-HSA-8876725 2.044398e-01 0.689 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.149113e-01 0.668 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.324732e-01 0.634 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.986175e-01 0.702 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.749018e-01 0.757 0 0
Signaling by NOTCH R-HSA-157118 1.746297e-01 0.758 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.981467e-01 0.703 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.571340e-01 0.590 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.818048e-01 0.740 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.571340e-01 0.590 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.422781e-01 0.616 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.571340e-01 0.590 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.818048e-01 0.740 0 0
Regulation of TP53 Activity R-HSA-5633007 2.128950e-01 0.672 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.571340e-01 0.590 0 0
IRE1alpha activates chaperones R-HSA-381070 2.095335e-01 0.679 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.086154e-01 0.681 0 0
SARS-CoV Infections R-HSA-9679506 2.078568e-01 0.682 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.136910e-01 0.670 0 0
Oncogene Induced Senescence R-HSA-2559585 2.617180e-01 0.582 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.788703e-01 0.555 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.788703e-01 0.555 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.788703e-01 0.555 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.788703e-01 0.555 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.788703e-01 0.555 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.354751e-01 0.474 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.876399e-01 0.412 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.876399e-01 0.412 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.876399e-01 0.412 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.876399e-01 0.412 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.876399e-01 0.412 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.871955e-01 0.542 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.871955e-01 0.542 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.171172e-01 0.499 0 0
Signaling by APC mutants R-HSA-4839744 3.171172e-01 0.499 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.171172e-01 0.499 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.171172e-01 0.499 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.171172e-01 0.499 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.357127e-01 0.361 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.357127e-01 0.361 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.357127e-01 0.361 0 0
Defective F9 activation R-HSA-9673221 4.357127e-01 0.361 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.687865e-01 0.571 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.687865e-01 0.571 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.467359e-01 0.460 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.907656e-01 0.536 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.907656e-01 0.536 0 0
Regulation of signaling by CBL R-HSA-912631 3.128620e-01 0.505 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.128620e-01 0.505 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.128620e-01 0.505 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.759150e-01 0.425 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.800141e-01 0.319 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.800141e-01 0.319 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.800141e-01 0.319 0 0
PDE3B signalling R-HSA-165160 4.800141e-01 0.319 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.800141e-01 0.319 0 0
PKB-mediated events R-HSA-109703 4.800141e-01 0.319 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.851534e-01 0.545 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.851534e-01 0.545 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.851534e-01 0.545 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.349960e-01 0.475 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.032559e-01 0.518 0 0
HIV elongation arrest and recovery R-HSA-167287 3.032559e-01 0.518 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.032559e-01 0.518 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.045410e-01 0.393 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.771021e-01 0.557 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.771021e-01 0.557 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.570937e-01 0.447 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.570937e-01 0.447 0 0
Basigin interactions R-HSA-210991 3.570937e-01 0.447 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.214783e-01 0.493 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.214783e-01 0.493 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.790872e-01 0.421 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.790872e-01 0.421 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.790872e-01 0.421 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.325212e-01 0.364 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.325212e-01 0.364 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.208400e-01 0.283 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.208400e-01 0.283 0 0
Signaling by LTK in cancer R-HSA-9842640 5.208400e-01 0.283 0 0
STAT5 Activation R-HSA-9645135 5.208400e-01 0.283 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.208400e-01 0.283 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.208400e-01 0.283 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.208400e-01 0.283 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.719779e-01 0.565 0 0
FGFR2 alternative splicing R-HSA-6803529 4.009146e-01 0.397 0 0
Erythropoietin activates RAS R-HSA-9027284 4.597805e-01 0.337 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.597805e-01 0.337 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.597805e-01 0.337 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.597805e-01 0.337 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.597805e-01 0.337 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.225197e-01 0.374 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.225197e-01 0.374 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.946873e-01 0.404 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.731511e-01 0.564 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.128685e-01 0.384 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.862598e-01 0.313 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.309288e-01 0.366 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.689181e-01 0.433 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.119135e-01 0.291 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.855238e-01 0.314 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.276299e-01 0.369 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.004179e-01 0.397 0 0
Dual incision in TC-NER R-HSA-6782135 4.529320e-01 0.344 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.057883e-01 0.296 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.057883e-01 0.296 0 0
Cristae formation R-HSA-8949613 5.057883e-01 0.296 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.256299e-01 0.279 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.256299e-01 0.279 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.946873e-01 0.404 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.672180e-01 0.573 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.960362e-01 0.529 0 0
RNA Polymerase III Transcription R-HSA-74158 2.771021e-01 0.557 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.759150e-01 0.425 0 0
Aggrephagy R-HSA-9646399 3.400922e-01 0.468 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.783015e-01 0.320 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.871955e-01 0.542 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.438522e-01 0.353 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.537627e-01 0.343 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.268757e-01 0.370 0 0
GAB1 signalosome R-HSA-180292 2.907656e-01 0.536 0 0
Synthesis of DNA R-HSA-69239 2.719090e-01 0.566 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.029717e-01 0.395 0 0
PI3K/AKT activation R-HSA-198203 2.871955e-01 0.542 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.467359e-01 0.460 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.325212e-01 0.364 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.009146e-01 0.397 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.400922e-01 0.468 0 0
HATs acetylate histones R-HSA-3214847 2.923713e-01 0.534 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.862598e-01 0.313 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.183771e-01 0.285 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.309288e-01 0.366 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.361054e-01 0.474 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.357360e-01 0.474 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.800141e-01 0.319 0 0
Formation of axial mesoderm R-HSA-9796292 4.045410e-01 0.393 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.959261e-01 0.529 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.438522e-01 0.353 0 0
Meiosis R-HSA-1500620 3.516924e-01 0.454 0 0
Homology Directed Repair R-HSA-5693538 5.149135e-01 0.288 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.672180e-01 0.573 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.946873e-01 0.404 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.541969e-01 0.343 0 0
Integration of provirus R-HSA-162592 3.467359e-01 0.460 0 0
Myogenesis R-HSA-525793 2.672180e-01 0.573 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.438522e-01 0.353 0 0
Ca2+ pathway R-HSA-4086398 3.446691e-01 0.463 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.446691e-01 0.463 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.276299e-01 0.369 0 0
Formation of the posterior neural plate R-HSA-9832991 3.171172e-01 0.499 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.357127e-01 0.361 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.357127e-01 0.361 0 0
PTK6 Down-Regulation R-HSA-8849472 4.357127e-01 0.361 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.687865e-01 0.571 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.687865e-01 0.571 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.467359e-01 0.460 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.648668e-01 0.333 0 0
Tight junction interactions R-HSA-420029 4.648668e-01 0.333 0 0
Mitophagy R-HSA-5205647 4.309288e-01 0.366 0 0
UCH proteinases R-HSA-5689603 3.810980e-01 0.419 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.670687e-01 0.435 0 0
Protein ubiquitination R-HSA-8852135 3.689181e-01 0.433 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.057883e-01 0.296 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.871955e-01 0.542 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.672180e-01 0.573 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 3.876399e-01 0.412 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.687865e-01 0.571 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.672180e-01 0.573 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.800141e-01 0.319 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.325212e-01 0.364 0 0
Developmental Cell Lineages R-HSA-9734767 4.555390e-01 0.341 0 0
Mismatch Repair R-HSA-5358508 2.907656e-01 0.536 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.648668e-01 0.333 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.672180e-01 0.573 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.694798e-01 0.432 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.862598e-01 0.313 0 0
Calmodulin induced events R-HSA-111933 2.771021e-01 0.557 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.788703e-01 0.555 0 0
Signalling to ERK5 R-HSA-198765 2.788703e-01 0.555 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.788703e-01 0.555 0 0
MET interacts with TNS proteins R-HSA-8875513 3.354751e-01 0.474 0 0
NF-kB is activated and signals survival R-HSA-209560 3.467359e-01 0.460 0 0
Signaling by AXIN mutants R-HSA-4839735 3.467359e-01 0.460 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.467359e-01 0.460 0 0
Regulation of IFNG signaling R-HSA-877312 3.759150e-01 0.425 0 0
Pentose phosphate pathway disease R-HSA-6791465 4.800141e-01 0.319 0 0
CaM pathway R-HSA-111997 2.771021e-01 0.557 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.597805e-01 0.337 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.597805e-01 0.337 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.597805e-01 0.337 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.862598e-01 0.313 0 0
Cilium Assembly R-HSA-5617833 3.518082e-01 0.454 0 0
Insulin receptor recycling R-HSA-77387 5.256299e-01 0.279 0 0
PI3K Cascade R-HSA-109704 5.130088e-01 0.290 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.223757e-01 0.282 0 0
G-protein mediated events R-HSA-112040 2.737183e-01 0.563 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.299037e-01 0.367 0 0
Signalling to ERKs R-HSA-187687 4.488361e-01 0.348 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 4.225197e-01 0.374 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.926626e-01 0.534 0 0
Signaling by FGFR in disease R-HSA-1226099 3.567710e-01 0.448 0 0
Generic Transcription Pathway R-HSA-212436 3.529632e-01 0.452 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.871955e-01 0.542 0 0
Signal attenuation R-HSA-74749 2.871955e-01 0.542 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.357127e-01 0.361 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.325212e-01 0.364 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.630362e-01 0.440 0 0
TRP channels R-HSA-3295583 4.855238e-01 0.314 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.110232e-01 0.292 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.796483e-01 0.319 0 0
FLT3 signaling in disease R-HSA-9682385 2.771021e-01 0.557 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.876399e-01 0.412 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.357127e-01 0.361 0 0
Signaling by LTK R-HSA-9842663 3.759150e-01 0.425 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.800141e-01 0.319 0 0
Degradation of CDH1 R-HSA-9766229 4.978664e-01 0.303 0 0
NGF-stimulated transcription R-HSA-9031628 4.825485e-01 0.316 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.516924e-01 0.454 0 0
Neurexins and neuroligins R-HSA-6794361 3.670687e-01 0.435 0 0
Deubiquitination R-HSA-5688426 4.009703e-01 0.397 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.720378e-01 0.429 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.855238e-01 0.314 0 0
Hemostasis R-HSA-109582 4.072500e-01 0.390 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.436052e-01 0.353 0 0
Signaling by TGFBR3 R-HSA-9839373 4.514575e-01 0.345 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.741300e-01 0.324 0 0
NADE modulates death signalling R-HSA-205025 3.876399e-01 0.412 0 0
2-LTR circle formation R-HSA-164843 2.871955e-01 0.542 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.467359e-01 0.460 0 0
The NLRP3 inflammasome R-HSA-844456 3.128620e-01 0.505 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.800141e-01 0.319 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.009146e-01 0.397 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.119135e-01 0.291 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.024824e-01 0.299 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.880236e-01 0.411 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.244649e-01 0.372 0 0
Formation of definitive endoderm R-HSA-9823730 3.349960e-01 0.475 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.560516e-01 0.448 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.683801e-01 0.571 0 0
Protein hydroxylation R-HSA-9629569 3.349960e-01 0.475 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.183771e-01 0.285 0 0
Signaling by NOTCH4 R-HSA-9013694 5.051901e-01 0.297 0 0
Cardiogenesis R-HSA-9733709 3.946873e-01 0.404 0 0
G2/M Checkpoints R-HSA-69481 2.768903e-01 0.558 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.896256e-01 0.409 0 0
Histamine receptors R-HSA-390650 3.354751e-01 0.474 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.349960e-01 0.475 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 4.225197e-01 0.374 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.256299e-01 0.279 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.128620e-01 0.505 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.119135e-01 0.291 0 0
Diseases of programmed cell death R-HSA-9645723 2.739880e-01 0.562 0 0
Co-stimulation by CD28 R-HSA-389356 3.100697e-01 0.509 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.871955e-01 0.542 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.357127e-01 0.361 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.045410e-01 0.393 0 0
Downstream signal transduction R-HSA-186763 3.581027e-01 0.446 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.183771e-01 0.285 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.851534e-01 0.545 0 0
Insulin processing R-HSA-264876 2.851534e-01 0.545 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.759150e-01 0.425 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.946873e-01 0.404 0 0
Viral Infection Pathways R-HSA-9824446 5.075223e-01 0.295 0 0
Inflammasomes R-HSA-622312 5.256299e-01 0.279 0 0
VLDL assembly R-HSA-8866423 5.208400e-01 0.283 0 0
Nef and signal transduction R-HSA-164944 5.208400e-01 0.283 0 0
Formation of the anterior neural plate R-HSA-9823739 4.597805e-01 0.337 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.537627e-01 0.343 0 0
Signaling by PDGF R-HSA-186797 5.087417e-01 0.294 0 0
Signaling by ALK R-HSA-201556 3.241880e-01 0.489 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.862598e-01 0.313 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.171172e-01 0.499 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.648668e-01 0.333 0 0
Sensory processing of sound R-HSA-9659379 4.177128e-01 0.379 0 0
PECAM1 interactions R-HSA-210990 3.171172e-01 0.499 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.800141e-01 0.319 0 0
Neurofascin interactions R-HSA-447043 5.208400e-01 0.283 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.852814e-01 0.545 0 0
Growth hormone receptor signaling R-HSA-982772 4.225197e-01 0.374 0 0
Potential therapeutics for SARS R-HSA-9679191 3.035272e-01 0.518 0 0
Signaling by Interleukins R-HSA-449147 5.078507e-01 0.294 0 0
Neurodegenerative Diseases R-HSA-8863678 4.438522e-01 0.353 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.438522e-01 0.353 0 0
OAS antiviral response R-HSA-8983711 3.759150e-01 0.425 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.771021e-01 0.557 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.057883e-01 0.296 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.241880e-01 0.489 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.119135e-01 0.291 0 0
Signaling by Leptin R-HSA-2586552 2.871955e-01 0.542 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.264833e-01 0.486 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.597805e-01 0.337 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.183771e-01 0.285 0 0
Interleukin-37 signaling R-HSA-9008059 3.397751e-01 0.469 0 0
DNA Replication R-HSA-69306 5.334307e-01 0.273 0 0
HCMV Infection R-HSA-9609646 5.346577e-01 0.272 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.351207e-01 0.272 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.351207e-01 0.272 0 0
HIV Transcription Elongation R-HSA-167169 5.351207e-01 0.272 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.351207e-01 0.272 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.367081e-01 0.270 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.367081e-01 0.270 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.367081e-01 0.270 0 0
Glycogen storage diseases R-HSA-3229121 5.367081e-01 0.270 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.367081e-01 0.270 0 0
Specification of primordial germ cells R-HSA-9827857 5.367081e-01 0.270 0 0
TCR signaling R-HSA-202403 5.388143e-01 0.269 0 0
Orc1 removal from chromatin R-HSA-68949 5.427037e-01 0.265 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.427037e-01 0.265 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.445300e-01 0.264 0 0
DNA methylation R-HSA-5334118 5.450229e-01 0.264 0 0
mRNA Capping R-HSA-72086 5.450229e-01 0.264 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.515677e-01 0.258 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.572276e-01 0.254 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.584627e-01 0.253 0 0
Disinhibition of SNARE formation R-HSA-114516 5.584627e-01 0.253 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.584627e-01 0.253 0 0
PTK6 Expression R-HSA-8849473 5.584627e-01 0.253 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.584627e-01 0.253 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 5.584627e-01 0.253 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.584627e-01 0.253 0 0
LDL remodeling R-HSA-8964041 5.584627e-01 0.253 0 0
VLDL clearance R-HSA-8964046 5.584627e-01 0.253 0 0
Regulation of PTEN localization R-HSA-8948747 5.584627e-01 0.253 0 0
Netrin mediated repulsion signals R-HSA-418886 5.584627e-01 0.253 0 0
CHL1 interactions R-HSA-447041 5.584627e-01 0.253 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.584627e-01 0.253 0 0
Maturation of replicase proteins R-HSA-9694301 5.584627e-01 0.253 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.590899e-01 0.253 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.606204e-01 0.251 0 0
Polo-like kinase mediated events R-HSA-156711 5.606204e-01 0.251 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.606204e-01 0.251 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.606204e-01 0.251 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.606204e-01 0.251 0 0
Platelet sensitization by LDL R-HSA-432142 5.606204e-01 0.251 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.606204e-01 0.251 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.606204e-01 0.251 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.639093e-01 0.249 0 0
MHC class II antigen presentation R-HSA-2132295 5.639093e-01 0.249 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.639453e-01 0.249 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.648589e-01 0.248 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.677016e-01 0.246 0 0
Signaling by FGFR2 R-HSA-5654738 5.789175e-01 0.237 0 0
PKR-mediated signaling R-HSA-9833482 5.789175e-01 0.237 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.826903e-01 0.235 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.835084e-01 0.234 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.836360e-01 0.234 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.836360e-01 0.234 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.836360e-01 0.234 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.836360e-01 0.234 0 0
Maturation of nucleoprotein R-HSA-9694631 5.836360e-01 0.234 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.855666e-01 0.232 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.855666e-01 0.232 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.860925e-01 0.232 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.891486e-01 0.230 0 0
Signaling by TGFB family members R-HSA-9006936 5.930825e-01 0.227 0 0
RSK activation R-HSA-444257 5.931335e-01 0.227 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.931335e-01 0.227 0 0
phospho-PLA2 pathway R-HSA-111995 5.931335e-01 0.227 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.931335e-01 0.227 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.931335e-01 0.227 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.931335e-01 0.227 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.931335e-01 0.227 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.931335e-01 0.227 0 0
Regulation by c-FLIP R-HSA-3371378 5.931335e-01 0.227 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.931335e-01 0.227 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.931335e-01 0.227 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.931335e-01 0.227 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.931335e-01 0.227 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.931335e-01 0.227 0 0
Dimerization of procaspase-8 R-HSA-69416 5.931335e-01 0.227 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.931335e-01 0.227 0 0
Sodium/Proton exchangers R-HSA-425986 5.931335e-01 0.227 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.931335e-01 0.227 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.931335e-01 0.227 0 0
Interleukin-23 signaling R-HSA-9020933 5.931335e-01 0.227 0 0
Signaling by Insulin receptor R-HSA-74752 5.934209e-01 0.227 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.954281e-01 0.225 0 0
Opioid Signalling R-HSA-111885 5.961728e-01 0.225 0 0
Signaling by NTRKs R-HSA-166520 5.984263e-01 0.223 0 0
Signaling by FGFR4 R-HSA-5654743 5.989754e-01 0.223 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.989754e-01 0.223 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.993603e-01 0.222 0 0
TNF signaling R-HSA-75893 5.993603e-01 0.222 0 0
Ion homeostasis R-HSA-5578775 5.993603e-01 0.222 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.993603e-01 0.222 0 0
Signaling by WNT in cancer R-HSA-4791275 6.003102e-01 0.222 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.003102e-01 0.222 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.057483e-01 0.218 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.057483e-01 0.218 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.057483e-01 0.218 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.057483e-01 0.218 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.057483e-01 0.218 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.057483e-01 0.218 0 0
Glycogen synthesis R-HSA-3322077 6.057483e-01 0.218 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.057483e-01 0.218 0 0
Platelet degranulation R-HSA-114608 6.108153e-01 0.214 0 0
IRS-mediated signalling R-HSA-112399 6.128912e-01 0.213 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.129483e-01 0.213 0 0
G-protein beta:gamma signalling R-HSA-397795 6.177271e-01 0.209 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.177271e-01 0.209 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.177271e-01 0.209 0 0
Nuclear RNA decay R-HSA-9930044 6.177271e-01 0.209 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.177271e-01 0.209 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.177271e-01 0.209 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.236944e-01 0.205 0 0
CASP8 activity is inhibited R-HSA-5218900 6.250837e-01 0.204 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.250837e-01 0.204 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.250837e-01 0.204 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.250837e-01 0.204 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.250837e-01 0.204 0 0
ARMS-mediated activation R-HSA-170984 6.250837e-01 0.204 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.250837e-01 0.204 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.250837e-01 0.204 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.250837e-01 0.204 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.250837e-01 0.204 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.250837e-01 0.204 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.250837e-01 0.204 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.250837e-01 0.204 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.250837e-01 0.204 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.269573e-01 0.203 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.269573e-01 0.203 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.269573e-01 0.203 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.269573e-01 0.203 0 0
Signaling by FGFR3 R-HSA-5654741 6.288499e-01 0.201 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.346217e-01 0.197 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.346217e-01 0.197 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.369984e-01 0.196 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.377467e-01 0.195 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.388538e-01 0.195 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.432413e-01 0.192 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.432413e-01 0.192 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.460577e-01 0.190 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.460577e-01 0.190 0 0
Reproduction R-HSA-1474165 6.465020e-01 0.189 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.472685e-01 0.189 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.472685e-01 0.189 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.472685e-01 0.189 0 0
SLC transporter disorders R-HSA-5619102 6.492135e-01 0.188 0 0
Signal amplification R-HSA-392518 6.509887e-01 0.186 0 0
Signaling by NOTCH2 R-HSA-1980145 6.509887e-01 0.186 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.518344e-01 0.186 1 1
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.545267e-01 0.184 0 0
DNA replication initiation R-HSA-68952 6.545267e-01 0.184 0 0
Binding and entry of HIV virion R-HSA-173107 6.545267e-01 0.184 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.545267e-01 0.184 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.545267e-01 0.184 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.545267e-01 0.184 0 0
Pexophagy R-HSA-9664873 6.545267e-01 0.184 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 6.545267e-01 0.184 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.545267e-01 0.184 0 0
Josephin domain DUBs R-HSA-5689877 6.545267e-01 0.184 0 0
Telomere Maintenance R-HSA-157579 6.561043e-01 0.183 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.572606e-01 0.182 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.572606e-01 0.182 0 0
Circadian clock R-HSA-9909396 6.636634e-01 0.178 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.641373e-01 0.178 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.642463e-01 0.178 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.666920e-01 0.176 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.666920e-01 0.176 0 0
Signaling by KIT in disease R-HSA-9669938 6.666920e-01 0.176 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 6.666920e-01 0.176 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.666920e-01 0.176 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.666920e-01 0.176 0 0
PERK regulates gene expression R-HSA-381042 6.668250e-01 0.176 0 0
Pyruvate metabolism R-HSA-70268 6.680927e-01 0.175 0 0
Mitochondrial protein import R-HSA-1268020 6.763665e-01 0.170 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.763665e-01 0.170 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.763665e-01 0.170 0 0
Heme signaling R-HSA-9707616 6.763665e-01 0.170 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.813760e-01 0.167 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.816590e-01 0.166 0 0
LGI-ADAM interactions R-HSA-5682910 6.816590e-01 0.166 0 0
vRNP Assembly R-HSA-192905 6.816590e-01 0.166 0 0
vRNA Synthesis R-HSA-192814 6.816590e-01 0.166 0 0
Chylomicron assembly R-HSA-8963888 6.816590e-01 0.166 0 0
Bicarbonate transporters R-HSA-425381 6.816590e-01 0.166 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.816590e-01 0.166 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.816590e-01 0.166 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 6.816590e-01 0.166 0 0
Suppression of apoptosis R-HSA-9635465 6.816590e-01 0.166 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.816590e-01 0.166 0 0
Interleukin-2 signaling R-HSA-9020558 6.816590e-01 0.166 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.816590e-01 0.166 0 0
Triglyceride catabolism R-HSA-163560 6.821301e-01 0.166 0 0
Glycosphingolipid transport R-HSA-9845576 6.821301e-01 0.166 0 0
Gap junction trafficking and regulation R-HSA-157858 6.841678e-01 0.165 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.852420e-01 0.164 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.852420e-01 0.164 0 0
Syndecan interactions R-HSA-3000170 6.852420e-01 0.164 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.881918e-01 0.162 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.969052e-01 0.157 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.970510e-01 0.157 0 0
Base Excision Repair R-HSA-73884 6.983432e-01 0.156 0 0
IGF1R signaling cascade R-HSA-2428924 6.997203e-01 0.155 0 0
Insulin receptor signalling cascade R-HSA-74751 6.997203e-01 0.155 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.997203e-01 0.155 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.005881e-01 0.155 0 0
Deadenylation of mRNA R-HSA-429947 7.029358e-01 0.153 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.029358e-01 0.153 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.029358e-01 0.153 0 0
Complex III assembly R-HSA-9865881 7.029358e-01 0.153 0 0
Integration of energy metabolism R-HSA-163685 7.044273e-01 0.152 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.066620e-01 0.151 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.066620e-01 0.151 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.066620e-01 0.151 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.066620e-01 0.151 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.066620e-01 0.151 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.066620e-01 0.151 0 0
Plasmalogen biosynthesis R-HSA-75896 7.066620e-01 0.151 0 0
Meiotic recombination R-HSA-912446 7.095529e-01 0.149 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.109503e-01 0.148 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.111537e-01 0.148 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.175991e-01 0.144 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.197935e-01 0.143 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.197935e-01 0.143 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.197935e-01 0.143 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.197935e-01 0.143 0 0
Hyaluronan degradation R-HSA-2160916 7.197935e-01 0.143 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.197935e-01 0.143 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.216742e-01 0.142 0 0
Pentose phosphate pathway R-HSA-71336 7.248802e-01 0.140 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.297026e-01 0.137 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.297026e-01 0.137 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.297026e-01 0.137 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.297026e-01 0.137 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.297026e-01 0.137 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.297026e-01 0.137 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.297026e-01 0.137 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.297026e-01 0.137 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.297026e-01 0.137 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.297026e-01 0.137 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.297026e-01 0.137 0 0
MET activates RAS signaling R-HSA-8851805 7.297026e-01 0.137 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.297026e-01 0.137 0 0
Interleukin-15 signaling R-HSA-8983432 7.297026e-01 0.137 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.297026e-01 0.137 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.321611e-01 0.135 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.334164e-01 0.135 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.334164e-01 0.135 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.335841e-01 0.135 0 0
Parasite infection R-HSA-9664407 7.347300e-01 0.134 0 0
Leishmania phagocytosis R-HSA-9664417 7.347300e-01 0.134 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.347300e-01 0.134 0 0
DNA Repair R-HSA-73894 7.352165e-01 0.134 0 0
MET activates PTK2 signaling R-HSA-8874081 7.358373e-01 0.133 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.358373e-01 0.133 0 0
Metalloprotease DUBs R-HSA-5689901 7.358373e-01 0.133 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.358373e-01 0.133 0 0
Urea cycle R-HSA-70635 7.358373e-01 0.133 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.380912e-01 0.132 0 0
Glycogen metabolism R-HSA-8982491 7.380912e-01 0.132 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.380912e-01 0.132 0 0
Diseases of Immune System R-HSA-5260271 7.380912e-01 0.132 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.380912e-01 0.132 0 0
Transcription of the HIV genome R-HSA-167172 7.428473e-01 0.129 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.446091e-01 0.128 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.447819e-01 0.128 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.507941e-01 0.124 0 0
Processing of SMDT1 R-HSA-8949664 7.509347e-01 0.124 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.509347e-01 0.124 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.509347e-01 0.124 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.509347e-01 0.124 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.509347e-01 0.124 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.509347e-01 0.124 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.509347e-01 0.124 0 0
Maturation of nucleoprotein R-HSA-9683610 7.509347e-01 0.124 0 0
Interleukin-6 signaling R-HSA-1059683 7.509347e-01 0.124 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.510909e-01 0.124 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.510909e-01 0.124 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.510909e-01 0.124 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.510909e-01 0.124 0 0
G alpha (z) signalling events R-HSA-418597 7.557741e-01 0.122 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.572947e-01 0.121 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.626256e-01 0.118 0 0
Stimuli-sensing channels R-HSA-2672351 7.628769e-01 0.118 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.629975e-01 0.117 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.629975e-01 0.117 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.629975e-01 0.117 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.655795e-01 0.116 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.655795e-01 0.116 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.655795e-01 0.116 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.655795e-01 0.116 0 0
HCMV Late Events R-HSA-9610379 7.660070e-01 0.116 0 0
Signaling by FGFR1 R-HSA-5654736 7.663970e-01 0.116 0 0
Neutrophil degranulation R-HSA-6798695 7.672837e-01 0.115 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.698468e-01 0.114 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.705002e-01 0.113 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.705002e-01 0.113 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.705002e-01 0.113 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.705002e-01 0.113 0 0
Hydrolysis of LPC R-HSA-1483115 7.705002e-01 0.113 0 0
Physiological factors R-HSA-5578768 7.705002e-01 0.113 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.705002e-01 0.113 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.705002e-01 0.113 0 0
P2Y receptors R-HSA-417957 7.705002e-01 0.113 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.720743e-01 0.112 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.720743e-01 0.112 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.720743e-01 0.112 0 0
Signaling by Erythropoietin R-HSA-9006335 7.793290e-01 0.108 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.793290e-01 0.108 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.793290e-01 0.108 0 0
Platelet calcium homeostasis R-HSA-418360 7.793290e-01 0.108 0 0
Glucagon-type ligand receptors R-HSA-420092 7.793290e-01 0.108 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.812329e-01 0.107 0 0
Signaling by FGFR R-HSA-190236 7.856280e-01 0.105 0 0
Regulation of insulin secretion R-HSA-422356 7.856280e-01 0.105 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.859455e-01 0.105 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.869704e-01 0.104 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.885297e-01 0.103 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.885297e-01 0.103 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.885297e-01 0.103 0 0
G beta:gamma signalling through BTK R-HSA-8964315 7.885297e-01 0.103 0 0
Translesion synthesis by REV1 R-HSA-110312 7.885297e-01 0.103 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.885297e-01 0.103 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.885297e-01 0.103 0 0
p38MAPK events R-HSA-171007 7.885297e-01 0.103 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.885297e-01 0.103 0 0
DNA Damage Reversal R-HSA-73942 7.885297e-01 0.103 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.889576e-01 0.103 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.923663e-01 0.101 0 0
Formation of the cornified envelope R-HSA-6809371 7.929167e-01 0.101 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.950219e-01 0.100 0 0
Extension of Telomeres R-HSA-180786 7.961002e-01 0.099 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.961002e-01 0.099 0 0
Triglyceride metabolism R-HSA-8979227 7.961002e-01 0.099 0 0
Surfactant metabolism R-HSA-5683826 7.967115e-01 0.099 0 0
Signaling by ERBB4 R-HSA-1236394 7.986934e-01 0.098 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.047182e-01 0.094 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.047182e-01 0.094 0 0
Trafficking of AMPA receptors R-HSA-399719 8.047182e-01 0.094 0 0
Cargo concentration in the ER R-HSA-5694530 8.047182e-01 0.094 0 0
Translesion synthesis by POLI R-HSA-5656121 8.051439e-01 0.094 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.051439e-01 0.094 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.051439e-01 0.094 0 0
Killing mechanisms R-HSA-9664420 8.051439e-01 0.094 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.051439e-01 0.094 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.051439e-01 0.094 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.051439e-01 0.094 0 0
Activation of SMO R-HSA-5635838 8.051439e-01 0.094 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.051439e-01 0.094 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.051439e-01 0.094 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.051439e-01 0.094 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.051439e-01 0.094 0 0
Differentiation of T cells R-HSA-9945266 8.051439e-01 0.094 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.063173e-01 0.093 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.070209e-01 0.093 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.070209e-01 0.093 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.164120e-01 0.088 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.168859e-01 0.088 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.168859e-01 0.088 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.168859e-01 0.088 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.168859e-01 0.088 0 0
Translesion synthesis by POLK R-HSA-5655862 8.204537e-01 0.086 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.204537e-01 0.086 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.204537e-01 0.086 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.204537e-01 0.086 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.204537e-01 0.086 0 0
Heme assimilation R-HSA-9927020 8.204537e-01 0.086 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.204537e-01 0.086 0 0
Passive transport by Aquaporins R-HSA-432047 8.204537e-01 0.086 0 0
Coenzyme A biosynthesis R-HSA-196783 8.204537e-01 0.086 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.204537e-01 0.086 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.204537e-01 0.086 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.226822e-01 0.085 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.248970e-01 0.084 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.263190e-01 0.083 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.274748e-01 0.082 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.274748e-01 0.082 0 0
PCP/CE pathway R-HSA-4086400 8.303006e-01 0.081 0 0
Interferon Signaling R-HSA-913531 8.344326e-01 0.079 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.345614e-01 0.079 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.345614e-01 0.079 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.345614e-01 0.079 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.345614e-01 0.079 0 0
GPER1 signaling R-HSA-9634597 8.353329e-01 0.078 0 0
Gluconeogenesis R-HSA-70263 8.353329e-01 0.078 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.375392e-01 0.077 0 0
Mitochondrial biogenesis R-HSA-1592230 8.378599e-01 0.077 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.379335e-01 0.077 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.379335e-01 0.077 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.379335e-01 0.077 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.379335e-01 0.077 0 0
Protein folding R-HSA-391251 8.384809e-01 0.077 0 0
DNA Damage Bypass R-HSA-73893 8.439407e-01 0.074 0 0
tRNA processing R-HSA-72306 8.446033e-01 0.073 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.475614e-01 0.072 0 0
PKA activation R-HSA-163615 8.475614e-01 0.072 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.475614e-01 0.072 0 0
PKA activation in glucagon signalling R-HSA-164378 8.475614e-01 0.072 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 8.475614e-01 0.072 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.475614e-01 0.072 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.478147e-01 0.072 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.478147e-01 0.072 0 0
eNOS activation R-HSA-203615 8.478147e-01 0.072 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.478147e-01 0.072 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.478147e-01 0.072 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.478147e-01 0.072 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.478147e-01 0.072 0 0
Hyaluronan metabolism R-HSA-2142845 8.478147e-01 0.072 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.500471e-01 0.071 0 0
Amyloid fiber formation R-HSA-977225 8.512564e-01 0.070 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.521555e-01 0.069 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.539522e-01 0.069 0 0
Translation R-HSA-72766 8.539771e-01 0.069 0 0
Regulation of Apoptosis R-HSA-169911 8.571447e-01 0.067 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.571447e-01 0.067 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.571447e-01 0.067 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.572474e-01 0.067 0 0
Ub-specific processing proteases R-HSA-5689880 8.584593e-01 0.066 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.595406e-01 0.066 0 0
Translesion Synthesis by POLH R-HSA-110320 8.595406e-01 0.066 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.595406e-01 0.066 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.595406e-01 0.066 0 0
Specification of the neural plate border R-HSA-9834899 8.595406e-01 0.066 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.595406e-01 0.066 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.595406e-01 0.066 0 0
Diseases of hemostasis R-HSA-9671793 8.595406e-01 0.066 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.595406e-01 0.066 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.599904e-01 0.066 0 0
The phototransduction cascade R-HSA-2514856 8.599904e-01 0.066 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.602671e-01 0.065 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.605760e-01 0.065 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.659489e-01 0.063 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.659489e-01 0.063 0 0
Regulated Necrosis R-HSA-5218859 8.672644e-01 0.062 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.674586e-01 0.062 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.705791e-01 0.060 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.705791e-01 0.060 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.705791e-01 0.060 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.705791e-01 0.060 0 0
Signaling by NODAL R-HSA-1181150 8.705791e-01 0.060 0 0
Creatine metabolism R-HSA-71288 8.705791e-01 0.060 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.705791e-01 0.060 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.705791e-01 0.060 0 0
Signal transduction by L1 R-HSA-445144 8.705791e-01 0.060 0 0
Degradation of DVL R-HSA-4641258 8.742523e-01 0.058 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.742523e-01 0.058 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.807507e-01 0.055 0 0
G-protein activation R-HSA-202040 8.807507e-01 0.055 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.807507e-01 0.055 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.807507e-01 0.055 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.807507e-01 0.055 0 0
Signalling to RAS R-HSA-167044 8.807507e-01 0.055 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.807507e-01 0.055 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.807507e-01 0.055 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.807507e-01 0.055 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.807507e-01 0.055 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.807507e-01 0.055 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.820793e-01 0.054 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.820793e-01 0.054 0 0
Adaptive Immune System R-HSA-1280218 8.835812e-01 0.054 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.841519e-01 0.053 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.841519e-01 0.053 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.841519e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.894534e-01 0.051 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.901234e-01 0.051 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.901234e-01 0.051 0 0
Glutathione synthesis and recycling R-HSA-174403 8.901234e-01 0.051 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.963975e-01 0.047 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.963975e-01 0.047 0 0
Interleukin-2 family signaling R-HSA-451927 8.963975e-01 0.047 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.972598e-01 0.047 0 0
PI Metabolism R-HSA-1483255 8.986548e-01 0.046 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.987600e-01 0.046 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.987600e-01 0.046 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.987600e-01 0.046 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.987600e-01 0.046 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.987600e-01 0.046 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.987600e-01 0.046 0 0
LDL clearance R-HSA-8964038 8.987600e-01 0.046 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.029335e-01 0.044 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.067182e-01 0.043 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.067182e-01 0.043 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.067182e-01 0.043 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.067182e-01 0.043 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.067182e-01 0.043 0 0
Carnitine shuttle R-HSA-200425 9.067182e-01 0.043 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.090827e-01 0.041 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.090827e-01 0.041 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.090827e-01 0.041 0 0
HIV Transcription Initiation R-HSA-167161 9.090827e-01 0.041 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.090827e-01 0.041 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.090827e-01 0.041 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.090827e-01 0.041 0 0
Intra-Golgi traffic R-HSA-6811438 9.090827e-01 0.041 0 0
Peptide hormone metabolism R-HSA-2980736 9.093596e-01 0.041 0 0
Regulation of beta-cell development R-HSA-186712 9.105516e-01 0.041 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.105516e-01 0.041 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.112875e-01 0.040 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.112875e-01 0.040 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.114759e-01 0.040 0 0
Cardiac conduction R-HSA-5576891 9.120754e-01 0.040 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.140512e-01 0.039 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.140512e-01 0.039 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.140512e-01 0.039 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.140512e-01 0.039 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.140512e-01 0.039 0 0
Interleukin-6 family signaling R-HSA-6783589 9.140512e-01 0.039 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.148655e-01 0.039 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.148655e-01 0.039 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.148655e-01 0.039 0 0
Depyrimidination R-HSA-73928 9.148655e-01 0.039 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.151838e-01 0.038 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.159645e-01 0.038 0 0
Ion channel transport R-HSA-983712 9.166610e-01 0.038 0 0
Aquaporin-mediated transport R-HSA-445717 9.202829e-01 0.036 0 0
MAP kinase activation R-HSA-450294 9.202829e-01 0.036 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.203015e-01 0.036 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.208082e-01 0.036 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.208082e-01 0.036 0 0
G protein gated Potassium channels R-HSA-1296059 9.208082e-01 0.036 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.208082e-01 0.036 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.208082e-01 0.036 0 0
Formation of the nephric duct R-HSA-9830364 9.208082e-01 0.036 0 0
Laminin interactions R-HSA-3000157 9.208082e-01 0.036 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.208082e-01 0.036 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.247768e-01 0.034 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.254093e-01 0.034 0 0
Gap junction trafficking R-HSA-190828 9.254093e-01 0.034 0 0
Amine ligand-binding receptors R-HSA-375280 9.254093e-01 0.034 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.259914e-01 0.033 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.270344e-01 0.033 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.270344e-01 0.033 0 0
Sphingolipid catabolism R-HSA-9845614 9.270344e-01 0.033 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.270344e-01 0.033 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.290374e-01 0.032 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.293149e-01 0.032 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.302071e-01 0.031 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.302071e-01 0.031 0 0
Somitogenesis R-HSA-9824272 9.302071e-01 0.031 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.302071e-01 0.031 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.302071e-01 0.031 0 0
Parasitic Infection Pathways R-HSA-9824443 9.316406e-01 0.031 0 0
Leishmania infection R-HSA-9658195 9.316406e-01 0.031 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.319465e-01 0.031 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.325060e-01 0.030 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.325060e-01 0.030 0 0
Packaging Of Telomere Ends R-HSA-171306 9.327714e-01 0.030 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.327714e-01 0.030 0 0
Triglyceride biosynthesis R-HSA-75109 9.327714e-01 0.030 0 0
Synthesis of PE R-HSA-1483213 9.327714e-01 0.030 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.327714e-01 0.030 0 0
Cellular response to chemical stress R-HSA-9711123 9.345085e-01 0.029 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.347120e-01 0.029 0 0
Diseases of DNA repair R-HSA-9675135 9.347120e-01 0.029 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.347120e-01 0.029 0 0
Interleukin-1 family signaling R-HSA-446652 9.356063e-01 0.029 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.380576e-01 0.028 0 0
Pyroptosis R-HSA-5620971 9.380576e-01 0.028 0 0
Protein localization R-HSA-9609507 9.381499e-01 0.028 0 0
Synthesis of PC R-HSA-1483191 9.389403e-01 0.027 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.413269e-01 0.026 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.413269e-01 0.026 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.424385e-01 0.026 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.424385e-01 0.026 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.424385e-01 0.026 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.429285e-01 0.026 0 0
Thyroxine biosynthesis R-HSA-209968 9.429285e-01 0.026 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.429285e-01 0.026 0 0
DARPP-32 events R-HSA-180024 9.429285e-01 0.026 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.429285e-01 0.026 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.429285e-01 0.026 0 0
Co-inhibition by PD-1 R-HSA-389948 9.437467e-01 0.025 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.465378e-01 0.024 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.466291e-01 0.024 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.466291e-01 0.024 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.466291e-01 0.024 0 0
DAP12 signaling R-HSA-2424491 9.474166e-01 0.023 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.474166e-01 0.023 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.474166e-01 0.023 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.474166e-01 0.023 0 0
Neurotransmitter clearance R-HSA-112311 9.474166e-01 0.023 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.474166e-01 0.023 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.499875e-01 0.022 0 0
Interleukin-1 signaling R-HSA-9020702 9.505411e-01 0.022 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.508017e-01 0.022 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.508017e-01 0.022 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.515520e-01 0.022 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.515520e-01 0.022 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.515520e-01 0.022 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.515520e-01 0.022 0 0
Interleukin-17 signaling R-HSA-448424 9.531659e-01 0.021 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.533895e-01 0.021 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.553624e-01 0.020 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.553624e-01 0.020 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.553624e-01 0.020 0 0
Hedgehog 'on' state R-HSA-5632684 9.559090e-01 0.020 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.564548e-01 0.019 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.564548e-01 0.019 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.564548e-01 0.019 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.571933e-01 0.019 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.588733e-01 0.018 0 0
Recycling of bile acids and salts R-HSA-159418 9.588733e-01 0.018 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.593265e-01 0.018 0 0
RSV-host interactions R-HSA-9833110 9.597325e-01 0.018 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.600262e-01 0.018 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.600262e-01 0.018 0 0
Downstream TCR signaling R-HSA-202424 9.605659e-01 0.017 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.606924e-01 0.017 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.609496e-01 0.017 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.620161e-01 0.017 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.621083e-01 0.017 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.621083e-01 0.017 0 0
Platelet homeostasis R-HSA-418346 9.637157e-01 0.016 0 0
Paracetamol ADME R-HSA-9753281 9.645345e-01 0.016 0 0
Extracellular matrix organization R-HSA-1474244 9.646212e-01 0.016 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.650890e-01 0.015 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.650890e-01 0.015 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.650890e-01 0.015 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.655099e-01 0.015 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.655099e-01 0.015 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.668919e-01 0.015 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.678354e-01 0.014 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.678354e-01 0.014 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.678354e-01 0.014 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.678354e-01 0.014 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.678354e-01 0.014 0 0
Synthesis of PA R-HSA-1483166 9.690981e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9694635 9.694489e-01 0.013 0 0
Collagen formation R-HSA-1474290 9.702456e-01 0.013 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.703659e-01 0.013 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.703659e-01 0.013 0 0
GPVI-mediated activation cascade R-HSA-114604 9.703659e-01 0.013 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.711623e-01 0.013 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.711623e-01 0.013 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.712824e-01 0.013 0 0
Integrin cell surface interactions R-HSA-216083 9.712824e-01 0.013 0 0
Cholesterol biosynthesis R-HSA-191273 9.712824e-01 0.013 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.713397e-01 0.013 0 0
Transmission across Chemical Synapses R-HSA-112315 9.716505e-01 0.012 0 0
Neuronal System R-HSA-112316 9.720803e-01 0.012 0 0
G alpha (s) signalling events R-HSA-418555 9.723023e-01 0.012 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.724924e-01 0.012 0 0
G alpha (q) signalling events R-HSA-416476 9.726877e-01 0.012 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.726974e-01 0.012 0 0
Degradation of AXIN R-HSA-4641257 9.726974e-01 0.012 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.726974e-01 0.012 0 0
Cleavage of the damaged purine R-HSA-110331 9.726974e-01 0.012 0 0
NCAM1 interactions R-HSA-419037 9.726974e-01 0.012 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.726974e-01 0.012 0 0
Peroxisomal protein import R-HSA-9033241 9.730931e-01 0.012 0 0
Infectious disease R-HSA-5663205 9.743407e-01 0.011 0 0
Depurination R-HSA-73927 9.748456e-01 0.011 0 0
Elastic fibre formation R-HSA-1566948 9.748456e-01 0.011 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.748456e-01 0.011 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.748456e-01 0.011 0 0
tRNA Aminoacylation R-HSA-379724 9.748987e-01 0.011 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.750195e-01 0.011 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.765870e-01 0.010 0 0
Toll-like Receptor Cascades R-HSA-168898 9.766501e-01 0.010 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.768250e-01 0.010 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.768250e-01 0.010 0 0
Stabilization of p53 R-HSA-69541 9.768250e-01 0.010 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.768250e-01 0.010 0 0
RAS processing R-HSA-9648002 9.768250e-01 0.010 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.786486e-01 0.009 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.786486e-01 0.009 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.803289e-01 0.009 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.803289e-01 0.009 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.803289e-01 0.009 0 0
Maturation of spike protein R-HSA-9694548 9.803289e-01 0.009 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.803289e-01 0.009 0 0
Ion transport by P-type ATPases R-HSA-936837 9.810180e-01 0.008 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.818771e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9683701 9.818771e-01 0.008 0 0
Gastrulation R-HSA-9758941 9.828019e-01 0.008 0 0
Immune System R-HSA-168256 9.830879e-01 0.007 0 0
Activation of GABAB receptors R-HSA-991365 9.833034e-01 0.007 0 0
GABA B receptor activation R-HSA-977444 9.833034e-01 0.007 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.846176e-01 0.007 0 0
DAP12 interactions R-HSA-2172127 9.858285e-01 0.006 0 0
Proteasome assembly R-HSA-9907900 9.858285e-01 0.006 0 0
ER-Phagosome pathway R-HSA-1236974 9.865361e-01 0.006 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.869440e-01 0.006 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.869440e-01 0.006 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.869440e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.873741e-01 0.006 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.873741e-01 0.006 0 0
Neddylation R-HSA-8951664 9.877630e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.895979e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.896276e-01 0.005 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.896402e-01 0.005 0 0
Intraflagellar transport R-HSA-5620924 9.897913e-01 0.004 0 0
Metal ion SLC transporters R-HSA-425410 9.897913e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.897913e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.899605e-01 0.004 0 0
Disease R-HSA-1643685 9.900096e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.902514e-01 0.004 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.906524e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.908653e-01 0.004 0 0
Iron uptake and transport R-HSA-917937 9.912977e-01 0.004 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.912977e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.920180e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.932293e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.938355e-01 0.003 0 0
Hedgehog 'off' state R-HSA-5610787 9.942294e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.947037e-01 0.002 0 0
Keratinization R-HSA-6805567 9.948955e-01 0.002 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.951090e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.951209e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.953250e-01 0.002 0 0
Signaling by Hedgehog R-HSA-5358351 9.953936e-01 0.002 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.960661e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.961857e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.961857e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.961857e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.961857e-01 0.002 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.962475e-01 0.002 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.964862e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.967879e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.968331e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.970182e-01 0.001 0 0
Cellular response to hypoxia R-HSA-1234174 9.974697e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.975819e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.978077e-01 0.001 0 0
Kidney development R-HSA-9830369 9.978528e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.978528e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.978528e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.979630e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.980221e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.980221e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.983217e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.983217e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.983542e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.983542e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.984348e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.984540e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.984540e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984540e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.984829e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.986151e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.988715e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.988869e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.991301e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.991301e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.991655e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.991987e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.992090e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.994232e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.995034e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995369e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.996478e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.996667e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996921e-01 0.000 1 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997059e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997930e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.998320e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.998392e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998452e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998606e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998871e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998874e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999247e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999303e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999305e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999318e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999547e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999587e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999730e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999747e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999777e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999923e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999931e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999953e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999968e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999968e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999972e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999980e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999984e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999990e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999991e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999993e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999995e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999997e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways