PKCH

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A2RRP1 S473 Sugiyama NBAS NAG APKRSRLETRAGEEDEGEEDsDsDyEISAKARYFGYIKQGL
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NMY6 S26 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
O00571 S82 Sugiyama DDX3X DBX DDX3 ssKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRs
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O75821 T240 Sugiyama EIF3G EIF3S4 DGAsRRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFR
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S27 SIGNOR ANXA1 ANX1 LPC1 FLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNPssD
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05107 S745 SIGNOR|ELM|PSP ITGB2 CD18 MFI7 ALIHLSDLREyRRFEKEKLKsQWNNDNPLFKsAtttVMNPK
P05107 T758 SIGNOR|ELM|PSP ITGB2 CD18 MFI7 FEKEKLKsQWNNDNPLFKsAtttVMNPKFAES_________
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S26 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09211 S185 SIGNOR|PSP GSTP1 FAEES3 GST3 VLAPGCLDAFPLLSAYVGRLsARPKLKAFLASPEyVNLPIN
P09211 S43 SIGNOR|PSP GSTP1 FAEES3 GST3 ADQGQSWKEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtL
P09234 S19 Sugiyama SNRPC __MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKENVKDYYQ
P09651 S360 Sugiyama HNRNPA1 HNRPA1 PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651 S368 Sugiyama HNRNPA1 HNRPA1 FAKPRNQGGyGGssssssyGsGRRF________________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09651 Y357 Sugiyama HNRNPA1 HNRPA1 ssGPyGGGGQyFAKPRNQGGyGGssssssyGsGRRF_____
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15104 S322 Sugiyama GLUL GLNS GFHETSNINDFSAGVANRsAsIRIPRTVGQEKKGYFEDRRP
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P24723 S28 PSP PRKCH PKCL PRKCL FNGYLRVRIGEAVGLQPtRWsLRHsLFKKGHQLLDPYLTVS
P24723 S317 Sugiyama PRKCH PKCL PRKCL VNAVELAKTLAGMGLQPGNIsPtsKLVSRSTLRRQGKESSK
P24723 S32 PSP PRKCH PKCL PRKCL LRVRIGEAVGLQPtRWsLRHsLFKKGHQLLDPYLTVSVDQV
P24723 S599 Sugiyama PRKCH PKCL PRKCL EDATGILKSFMTKNPTMRLGsLtQGGEHAILRHPFFKEIDW
P24723 T177 Sugiyama PRKCH PKCL PRKCL KRQRAMRRRVHQINGHKFMAtyLRQPtYCSHCREFIWGVFG
P24723 T183 Sugiyama PRKCH PKCL PRKCL RRRVHQINGHKFMAtyLRQPtYCSHCREFIWGVFGKQGYQC
P24723 T207 Sugiyama PRKCH PKCL PRKCL HCREFIWGVFGKQGYQCQVCtCVVHKRCHHLIVTACTCQNN
P24723 T601 Sugiyama PRKCH PKCL PRKCL ATGILKSFMTKNPTMRLGsLtQGGEHAILRHPFFKEIDWAQ
P24723 Y178 Sugiyama PRKCH PKCL PRKCL RQRAMRRRVHQINGHKFMAtyLRQPtYCSHCREFIWGVFGK
P25789 S7 Sugiyama PSMA4 HC9 PSC9 ______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789 T9 Sugiyama PSMA4 HC9 PSC9 ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P35236 S246 SIGNOR PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49840 S21 SIGNOR|PSP GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 S9 SIGNOR|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P52789 S415 Sugiyama HK2 QRIKENKGEERLRstIGVDGsVyKKHPHFAKRLHKTVRRLV
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P55196 S216 Sugiyama AFDN AF6 MLLT4 SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P56270 S302 Sugiyama MAZ ZNF801 EMCGKAFRDVYHLNRHKLSHsDEKPyQCPVCQQRFKRKDRM
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62263 T140 Sugiyama RPS14 PRO2640 ARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL_________
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 Y196 Sugiyama YBX1 NSEP1 YB1 sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02156 T175 Sugiyama PRKCE PKCE KRQGAVRRRVHQVNGHKFMAtyLRQPtYCSHCRDFIWGVIG
Q02156 T181 Sugiyama PRKCE PKCE RRRVHQVNGHKFMAtyLRQPtYCSHCRDFIWGVIGKQGYQC
Q02156 T205 Sugiyama PRKCE PKCE HCRDFIWGVIGKQGYQCQVCtCVVHKRCHELIITKCAGLKK
Q02156 Y176 Sugiyama PRKCE PKCE RQGAVRRRVHQVNGHKFMAtyLRQPtYCSHCRDFIWGVIGK
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06124 S576 SIGNOR|PSP PTPN11 PTP2C SHPTP2 DQSPLPPCTPTPPCAEMREDsARVyENVGLMQQQKsFR___
Q06124 S591 PSP PTPN11 PTP2C SHPTP2 EMREDsARVyENVGLMQQQKsFR__________________
Q14004 S389 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 SYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVLRRSGKS
Q14103 S271 Sugiyama HNRNPD AUF1 HNRPD KCEIKVAMSKEQyQQQQQWGsRGGFAGRARGRGGGPSQNWN
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15139 S738 SIGNOR|ELM|iPTMNet|PSP PRKD1 PKD PKD1 PRKCM DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNK
Q15139 S742 SIGNOR|ELM|PSP PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q16629 S183 Sugiyama SRSF7 SFRS7 sRSISLRRSRSASLRRSRSGsIKGsRyFQsPsRsRsRSRSI
Q16629 S187 Sugiyama SRSF7 SFRS7 SLRRSRSASLRRSRSGsIKGsRyFQsPsRsRsRSRSISRPR
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6 S706 SIGNOR|PSP PRKD2 PKD2 HSPC187 DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQ
Q9BZL6 S710 SIGNOR|PSP PRKD2 PKD2 HSPC187 QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNR
Q9BZL6 S876 SIGNOR|PSP PRKD2 PKD2 HSPC187 DLGGACPPQDHDMQGLAERIsVL__________________
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NYF8 S297 Sugiyama BCLAF1 BTF KIAA0164 VGNGssRysPsQNsPIHHIPsRRsPAKtIAPQNAPRDEsRG
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9ULX6 T267 Sugiyama AKAP8L NAKAP NAKAP95 HRIHFB2018 RFGFGFGNGMKQMRRTWKTWtTADFRTKKKKRKQGGsPDEP
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.771561e-16 15.109 0 0
Signal Transduction R-HSA-162582 3.796963e-14 13.421 1 0
Cell Cycle Checkpoints R-HSA-69620 1.321165e-12 11.879 0 0
Cellular Senescence R-HSA-2559583 1.417200e-12 11.849 0 0
Cell Cycle, Mitotic R-HSA-69278 5.371703e-12 11.270 0 0
M Phase R-HSA-68886 2.951099e-10 9.530 0 0
Axon guidance R-HSA-422475 4.014818e-10 9.396 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.238404e-10 9.084 0 0
Nervous system development R-HSA-9675108 2.155219e-09 8.667 0 0
Apoptotic execution phase R-HSA-75153 3.333855e-09 8.477 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.624820e-09 8.179 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.446173e-09 8.073 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.549598e-08 7.594 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.701906e-08 7.568 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.428319e-08 7.354 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.859467e-08 7.232 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.244711e-08 7.204 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.884280e-08 7.162 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.029435e-08 7.153 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.307591e-08 7.136 0 0
DNA methylation R-HSA-5334118 7.719462e-08 7.112 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.088684e-07 6.963 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.219064e-07 6.914 0 0
Packaging Of Telomere Ends R-HSA-171306 1.331259e-07 6.876 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.331259e-07 6.876 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.427862e-07 6.845 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.694265e-07 6.771 0 0
Diseases of programmed cell death R-HSA-9645723 1.703298e-07 6.769 0 0
HATs acetylate histones R-HSA-3214847 1.858564e-07 6.731 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.216041e-07 6.654 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.381413e-07 6.623 0 0
Mitotic Prophase R-HSA-68875 2.938335e-07 6.532 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.906581e-07 6.537 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.996735e-07 6.398 0 0
Mitotic Anaphase R-HSA-68882 4.563606e-07 6.341 0 0
Meiotic synapsis R-HSA-1221632 4.955429e-07 6.305 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.261124e-07 6.279 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.460221e-07 6.190 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.460221e-07 6.190 0 0
Meiotic recombination R-HSA-912446 8.643132e-07 6.063 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.286319e-07 6.032 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.601908e-07 6.018 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.228796e-06 5.911 0 0
Meiosis R-HSA-1500620 1.319839e-06 5.879 0 0
Chromatin modifying enzymes R-HSA-3247509 1.357521e-06 5.867 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.746448e-06 5.758 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.761544e-06 5.754 0 0
Separation of Sister Chromatids R-HSA-2467813 1.921537e-06 5.716 0 0
Regulation of TP53 Activity R-HSA-5633007 2.187691e-06 5.660 0 0
Defective pyroptosis R-HSA-9710421 2.474662e-06 5.606 0 0
Chromatin organization R-HSA-4839726 2.489938e-06 5.604 0 0
DNA Double Strand Break Response R-HSA-5693606 2.680892e-06 5.572 0 0
HDACs deacetylate histones R-HSA-3214815 2.779038e-06 5.556 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.881426e-06 5.540 0 0
Cleavage of the damaged purine R-HSA-110331 2.835190e-06 5.547 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.147153e-06 5.502 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.298750e-06 5.482 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.474076e-06 5.459 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.738916e-06 5.427 0 0
Depurination R-HSA-73927 3.977835e-06 5.400 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.307621e-06 5.366 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.307621e-06 5.366 0 0
Cellular responses to stress R-HSA-2262752 4.331768e-06 5.363 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.587494e-06 5.338 0 0
Nucleosome assembly R-HSA-774815 4.587494e-06 5.338 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.803988e-06 5.318 0 0
Signaling by Hippo R-HSA-2028269 5.602392e-06 5.252 0 0
Cellular responses to stimuli R-HSA-8953897 6.038407e-06 5.219 0 0
G2/M Checkpoints R-HSA-69481 6.821973e-06 5.166 0 0
Mitotic Prometaphase R-HSA-68877 8.266244e-06 5.083 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.593356e-06 5.018 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.700533e-06 5.013 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.073689e-05 4.969 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.104589e-05 4.957 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.862659e-05 4.730 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.868412e-05 4.729 0 0
Depyrimidination R-HSA-73928 1.868412e-05 4.729 0 0
Cell-Cell communication R-HSA-1500931 2.075357e-05 4.683 0 0
Kinesins R-HSA-983189 2.844399e-05 4.546 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.909009e-05 4.536 0 0
Homology Directed Repair R-HSA-5693538 3.004586e-05 4.522 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.341015e-05 4.362 0 0
L1CAM interactions R-HSA-373760 4.694328e-05 4.328 0 0
Apoptosis R-HSA-109581 4.962689e-05 4.304 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.749318e-05 4.171 0 0
Recycling pathway of L1 R-HSA-437239 7.117116e-05 4.148 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.140006e-05 4.146 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.529697e-05 4.123 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.596398e-05 4.119 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.960722e-05 4.099 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.512183e-05 4.070 0 0
Metalloprotease DUBs R-HSA-5689901 8.568019e-05 4.067 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.624008e-05 4.064 0 0
Post NMDA receptor activation events R-HSA-438064 9.093252e-05 4.041 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.132133e-04 3.946 0 0
Reproduction R-HSA-1474165 1.166169e-04 3.933 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.175074e-04 3.930 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.270395e-04 3.896 0 0
ESR-mediated signaling R-HSA-8939211 1.339715e-04 3.873 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.351064e-04 3.869 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.360373e-04 3.866 0 0
Programmed Cell Death R-HSA-5357801 1.371488e-04 3.863 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.522477e-04 3.817 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.716950e-04 3.765 0 0
Cell junction organization R-HSA-446728 1.736121e-04 3.760 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.913989e-04 3.718 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.809232e-04 3.743 0 0
NRAGE signals death through JNK R-HSA-193648 2.097839e-04 3.678 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.155958e-04 3.666 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.155958e-04 3.666 0 0
Developmental Biology R-HSA-1266738 2.365222e-04 3.626 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.892521e-04 3.539 0 0
RNA Polymerase II Transcription R-HSA-73857 3.540862e-04 3.451 0 0
Gene Silencing by RNA R-HSA-211000 3.557575e-04 3.449 0 0
mRNA Splicing R-HSA-72172 3.801911e-04 3.420 0 0
G alpha (12/13) signalling events R-HSA-416482 4.183527e-04 3.378 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.987551e-04 3.399 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.987551e-04 3.399 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.987551e-04 3.399 0 0
Signaling by VEGF R-HSA-194138 3.987551e-04 3.399 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.247957e-04 3.372 0 0
HCMV Early Events R-HSA-9609690 4.577040e-04 3.339 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.577040e-04 3.339 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.310348e-04 3.275 0 0
mRNA 3'-end processing R-HSA-72187 5.773874e-04 3.239 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.827415e-04 3.235 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.099249e-04 3.215 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.249376e-04 3.204 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.887611e-04 3.162 0 0
Deubiquitination R-HSA-5688426 7.182989e-04 3.144 0 0
Gene expression (Transcription) R-HSA-74160 7.623571e-04 3.118 0 0
Chromosome Maintenance R-HSA-73886 7.792847e-04 3.108 0 0
Gap junction trafficking and regulation R-HSA-157858 7.806030e-04 3.108 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.010808e-04 3.096 0 0
FOXO-mediated transcription R-HSA-9614085 8.277791e-04 3.082 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.289612e-04 3.032 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.586473e-04 3.066 0 0
Rap1 signalling R-HSA-392517 8.578435e-04 3.067 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.904981e-04 3.050 0 0
Signaling by ROBO receptors R-HSA-376176 9.081529e-04 3.042 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.314137e-04 3.031 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.425161e-04 3.026 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.425161e-04 3.026 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.094995e-03 2.961 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.153121e-03 2.938 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.183900e-03 2.927 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.200850e-03 2.921 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.201659e-03 2.920 0 0
Telomere Maintenance R-HSA-157579 1.256165e-03 2.901 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.273839e-03 2.895 0 0
Generic Transcription Pathway R-HSA-212436 1.360244e-03 2.866 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.432688e-03 2.844 0 0
Base Excision Repair R-HSA-73884 1.458079e-03 2.836 0 0
Interleukin-12 signaling R-HSA-9020591 1.432688e-03 2.844 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.557215e-03 2.808 0 0
Aggrephagy R-HSA-9646399 1.578251e-03 2.802 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.605459e-03 2.794 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.638312e-03 2.786 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.726519e-03 2.763 0 0
Gap junction trafficking R-HSA-190828 1.747973e-03 2.757 0 0
Semaphorin interactions R-HSA-373755 1.833574e-03 2.737 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.846587e-03 2.734 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.869420e-03 2.728 0 0
RNA Polymerase I Transcription R-HSA-73864 1.934343e-03 2.713 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.941518e-03 2.712 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.106755e-03 2.676 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.956731e-03 2.708 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.112976e-03 2.675 0 0
Cell-cell junction organization R-HSA-421270 2.088089e-03 2.680 0 0
Adherens junctions interactions R-HSA-418990 2.286552e-03 2.641 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.372147e-03 2.625 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.396294e-03 2.620 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.463248e-03 2.608 0 0
Interleukin-37 signaling R-HSA-9008059 2.534432e-03 2.596 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.874263e-03 2.541 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.898430e-03 2.538 0 0
Gap junction assembly R-HSA-190861 2.911770e-03 2.536 0 0
Amyloid fiber formation R-HSA-977225 2.963802e-03 2.528 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.974036e-03 2.527 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.322055e-03 2.479 0 0
Signaling by NOTCH R-HSA-157118 3.374459e-03 2.472 0 0
Ub-specific processing proteases R-HSA-5689880 3.393271e-03 2.469 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.543999e-03 2.451 0 0
Oncogene Induced Senescence R-HSA-2559585 3.588857e-03 2.445 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.932049e-03 2.405 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.079665e-03 2.389 0 0
DNA Repair R-HSA-73894 4.038091e-03 2.394 0 0
Netrin-1 signaling R-HSA-373752 4.164300e-03 2.380 0 0
RMTs methylate histone arginines R-HSA-3214858 4.164300e-03 2.380 0 0
EPH-Ephrin signaling R-HSA-2682334 4.226046e-03 2.374 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.674312e-03 2.330 0 0
Neurodegenerative Diseases R-HSA-8863678 4.676865e-03 2.330 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.676865e-03 2.330 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.685199e-03 2.329 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.844397e-03 2.315 0 0
Signaling by ALK in cancer R-HSA-9700206 4.844397e-03 2.315 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.274023e-03 2.278 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.538408e-03 2.257 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.346048e-03 2.197 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.367563e-03 2.196 0 0
Activation of RAC1 R-HSA-428540 6.492608e-03 2.188 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.889435e-03 2.162 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.910098e-03 2.161 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.018797e-03 2.154 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.144141e-03 2.089 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.115941e-03 2.091 0 0
MAPK family signaling cascades R-HSA-5683057 7.771368e-03 2.110 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.579560e-03 2.120 0 0
Interleukin-12 family signaling R-HSA-447115 7.255081e-03 2.139 0 0
Selective autophagy R-HSA-9663891 8.158332e-03 2.088 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.184503e-03 2.087 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.294782e-03 2.081 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.294782e-03 2.081 0 0
Metabolism of RNA R-HSA-8953854 8.867150e-03 2.052 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 9.045084e-03 2.044 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.186488e-03 2.037 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.488422e-03 2.023 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.813621e-03 2.008 0 0
G2/M Transition R-HSA-69275 9.912219e-03 2.004 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.935879e-03 2.003 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.014503e-02 1.994 0 0
HCMV Infection R-HSA-9609646 1.033186e-02 1.986 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.108758e-02 1.955 0 0
Death Receptor Signaling R-HSA-73887 1.111331e-02 1.954 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.143804e-02 1.942 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.143804e-02 1.942 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.143804e-02 1.942 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.178479e-02 1.929 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.191902e-02 1.924 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.191902e-02 1.924 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.191902e-02 1.924 0 0
Integrin signaling R-HSA-354192 1.196445e-02 1.922 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.196445e-02 1.922 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.411924e-02 1.850 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.411924e-02 1.850 0 0
Muscle contraction R-HSA-397014 1.290811e-02 1.889 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.332191e-02 1.875 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.429671e-02 1.845 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.481330e-02 1.829 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.507359e-02 1.822 1 0
Adaptive Immune System R-HSA-1280218 1.618580e-02 1.791 0 0
DNA Replication R-HSA-69306 1.621114e-02 1.790 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.635649e-02 1.786 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.635649e-02 1.786 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.653446e-02 1.782 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.722482e-02 1.764 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.722482e-02 1.764 0 0
Opioid Signalling R-HSA-111885 1.725436e-02 1.763 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.782705e-02 1.749 0 0
Signaling by Interleukins R-HSA-449147 1.821999e-02 1.739 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.872604e-02 1.728 0 0
TRP channels R-HSA-3295583 1.872604e-02 1.728 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.883968e-02 1.725 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.897673e-02 1.722 0 0
Ephrin signaling R-HSA-3928664 1.927871e-02 1.715 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.038366e-02 1.691 0 0
Signaling by WNT R-HSA-195721 2.092828e-02 1.679 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.104403e-02 1.677 0 0
Membrane Trafficking R-HSA-199991 2.111201e-02 1.675 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.128944e-02 1.672 0 0
Adrenoceptors R-HSA-390696 2.211751e-02 1.655 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.225322e-02 1.653 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.401782e-02 1.619 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.251763e-02 1.647 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.328254e-02 1.633 0 0
Co-inhibition by PD-1 R-HSA-389948 2.613427e-02 1.583 0 0
G-protein mediated events R-HSA-112040 2.568109e-02 1.590 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.328254e-02 1.633 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.560700e-02 1.592 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.474610e-02 1.606 0 0
MHC class II antigen presentation R-HSA-2132295 2.673002e-02 1.573 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.675899e-02 1.573 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.675899e-02 1.573 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.710770e-02 1.567 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.722862e-02 1.565 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.791989e-02 1.554 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.875766e-02 1.541 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.897787e-02 1.538 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.900997e-02 1.537 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.900997e-02 1.537 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.900997e-02 1.537 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.917259e-02 1.535 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.917259e-02 1.535 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.917259e-02 1.535 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.917259e-02 1.535 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.917259e-02 1.535 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.931750e-02 1.533 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.010303e-02 1.521 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.079141e-02 1.512 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.143276e-02 1.503 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.171534e-02 1.499 0 0
PKR-mediated signaling R-HSA-9833482 3.182199e-02 1.497 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.382062e-02 1.471 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.382062e-02 1.471 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.382062e-02 1.471 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.382062e-02 1.471 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.382062e-02 1.471 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.382062e-02 1.471 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.382062e-02 1.471 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.382062e-02 1.471 0 0
Co-stimulation by CD28 R-HSA-389356 3.398182e-02 1.469 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.718664e-02 1.430 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.718664e-02 1.430 0 0
RAF activation R-HSA-5673000 3.685481e-02 1.434 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.612981e-02 1.442 0 0
Translation initiation complex formation R-HSA-72649 3.679112e-02 1.434 0 0
Metabolism of non-coding RNA R-HSA-194441 3.516000e-02 1.454 0 0
snRNP Assembly R-HSA-191859 3.516000e-02 1.454 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.731416e-02 1.428 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.534167e-02 1.452 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.830787e-02 1.417 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.830787e-02 1.417 0 0
Signal amplification R-HSA-392518 3.685481e-02 1.434 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.122158e-02 1.385 0 0
Regulation of CDH11 function R-HSA-9762292 4.065174e-02 1.391 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.737224e-02 1.427 0 0
Cardiac conduction R-HSA-5576891 3.682453e-02 1.434 0 0
Nuclear import of Rev protein R-HSA-180746 3.685481e-02 1.434 0 0
Macroautophagy R-HSA-1632852 3.487366e-02 1.458 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.130300e-02 1.384 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.130300e-02 1.384 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.166751e-02 1.380 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.246681e-02 1.372 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.246681e-02 1.372 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.327816e-02 1.364 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.327816e-02 1.364 0 0
Peptide chain elongation R-HSA-156902 4.354161e-02 1.361 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.354777e-02 1.361 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.512804e-02 1.346 0 0
Ion homeostasis R-HSA-5578775 4.601956e-02 1.337 0 0
Signaling by EGFR R-HSA-177929 4.601956e-02 1.337 0 0
Regulation of KIT signaling R-HSA-1433559 4.691219e-02 1.329 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.691219e-02 1.329 0 0
FLT3 Signaling R-HSA-9607240 4.697163e-02 1.328 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.798240e-02 1.319 0 0
RET signaling R-HSA-8853659 4.864112e-02 1.313 0 0
HCMV Late Events R-HSA-9610379 4.897004e-02 1.310 0 0
Neuronal System R-HSA-112316 5.202517e-02 1.284 0 0
Signaling by APC mutants R-HSA-4839744 5.261936e-02 1.279 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.261936e-02 1.279 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.261936e-02 1.279 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.261936e-02 1.279 0 0
Interleukin-2 signaling R-HSA-9020558 5.261936e-02 1.279 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.357336e-02 1.271 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.496267e-02 1.260 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.539654e-02 1.257 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.539654e-02 1.257 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.938763e-02 1.159 0 0
Oligomerization of connexins into connexons R-HSA-190704 6.938763e-02 1.159 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.938763e-02 1.159 0 0
Transport of connexins along the secretory pathway R-HSA-190827 6.938763e-02 1.159 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 6.938763e-02 1.159 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 6.938763e-02 1.159 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.938763e-02 1.159 0 0
Dopamine receptors R-HSA-390651 5.598693e-02 1.252 0 0
Regulation of gap junction activity R-HSA-191650 5.598693e-02 1.252 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.598693e-02 1.252 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.598693e-02 1.252 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.598693e-02 1.252 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.698444e-02 1.244 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.642686e-02 1.178 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.642686e-02 1.178 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.783174e-02 1.238 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.783174e-02 1.238 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.796164e-02 1.168 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.741631e-02 1.241 0 0
Striated Muscle Contraction R-HSA-390522 6.550011e-02 1.184 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.612967e-02 1.251 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.344348e-02 1.198 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.741631e-02 1.241 0 0
Platelet calcium homeostasis R-HSA-418360 6.796164e-02 1.168 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.676661e-02 1.246 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.741631e-02 1.241 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.598693e-02 1.252 0 0
Potassium Channels R-HSA-1296071 6.162595e-02 1.210 0 0
MTOR signalling R-HSA-165159 5.986168e-02 1.223 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.550011e-02 1.184 1 1
Pyroptosis R-HSA-5620971 5.904003e-02 1.229 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.274876e-02 1.202 0 0
Protein ubiquitination R-HSA-8852135 5.728047e-02 1.242 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.783174e-02 1.238 0 0
Autophagy R-HSA-9612973 6.655517e-02 1.177 0 0
Stimuli-sensing channels R-HSA-2672351 6.738745e-02 1.171 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.698444e-02 1.244 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.642686e-02 1.178 0 0
Signaling by AXIN mutants R-HSA-4839735 6.642686e-02 1.178 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.582817e-02 1.182 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.612967e-02 1.251 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.550011e-02 1.184 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.828415e-02 1.234 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.274876e-02 1.202 0 0
Phosphorylation of the APC/C R-HSA-176412 7.014907e-02 1.154 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.014907e-02 1.154 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.071013e-02 1.151 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.085466e-02 1.150 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.116825e-02 1.148 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.222882e-02 1.141 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.416461e-02 1.130 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.427786e-02 1.129 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.427786e-02 1.129 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.427786e-02 1.129 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.491184e-02 1.125 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.491184e-02 1.125 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.491184e-02 1.125 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.521537e-02 1.124 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.542150e-02 1.123 0 0
Activation of BH3-only proteins R-HSA-114452 7.768361e-02 1.110 0 0
Interferon Signaling R-HSA-913531 7.840532e-02 1.106 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.928953e-02 1.101 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 8.030710e-02 1.095 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.030710e-02 1.095 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.030710e-02 1.095 0 0
HDMs demethylate histones R-HSA-3214842 8.071133e-02 1.093 0 0
Long-term potentiation R-HSA-9620244 8.071133e-02 1.093 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.071133e-02 1.093 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.098673e-02 1.092 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.098673e-02 1.092 0 0
Immune System R-HSA-168256 8.180366e-02 1.087 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.205662e-02 1.086 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.244308e-02 1.084 0 0
Glycolysis R-HSA-70171 8.271213e-02 1.082 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.313410e-02 1.080 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.126144e-01 0.948 0 0
Regulation of TP53 Expression R-HSA-6804754 1.126144e-01 0.948 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.126144e-01 0.948 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.126144e-01 0.948 0 0
Diseases of cellular response to stress R-HSA-9675132 1.126144e-01 0.948 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.126144e-01 0.948 0 0
Potassium transport channels R-HSA-1296067 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.126144e-01 0.948 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.126144e-01 0.948 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.126144e-01 0.948 0 0
Phosphorylation of Emi1 R-HSA-176417 1.083781e-01 0.965 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.532995e-02 1.021 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 9.532995e-02 1.021 0 0
Gap junction degradation R-HSA-190873 9.532995e-02 1.021 0 0
ALK mutants bind TKIs R-HSA-9700645 9.532995e-02 1.021 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.945672e-02 1.002 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.945672e-02 1.002 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.945672e-02 1.002 0 0
Notch-HLH transcription pathway R-HSA-350054 1.105961e-01 0.956 0 0
Trafficking of AMPA receptors R-HSA-399719 8.821063e-02 1.054 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.051714e-01 0.978 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.051714e-01 0.978 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.116669e-01 0.952 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.116669e-01 0.952 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.048246e-01 0.980 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.217799e-02 1.035 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.217799e-02 1.035 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.217799e-02 1.035 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.217799e-02 1.035 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.223821e-02 1.035 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.465261e-02 1.024 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.016857e-01 0.993 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.051714e-01 0.978 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.116669e-01 0.952 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 9.532995e-02 1.021 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.001879e-01 0.999 0 0
G0 and Early G1 R-HSA-1538133 9.954105e-02 1.002 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.083781e-01 0.965 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.116669e-01 0.952 0 0
Calmodulin induced events R-HSA-111933 9.393989e-02 1.027 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.532995e-02 1.021 0 0
Signaling by RAS mutants R-HSA-6802949 9.217799e-02 1.035 0 0
Ca-dependent events R-HSA-111996 1.087698e-01 0.963 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.945672e-02 1.002 0 0
Signaling by WNT in cancer R-HSA-4791275 9.954105e-02 1.002 0 0
CaM pathway R-HSA-111997 9.393989e-02 1.027 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.153053e-01 0.938 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.153053e-01 0.938 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.153053e-01 0.938 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.153053e-01 0.938 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.153053e-01 0.938 0 0
GPER1 signaling R-HSA-9634597 1.116901e-01 0.952 0 0
Calcineurin activates NFAT R-HSA-2025928 9.532995e-02 1.021 0 0
Signaling by TGFBR3 R-HSA-9839373 9.217799e-02 1.035 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.831968e-02 1.007 0 0
Signaling by NOTCH1 R-HSA-1980143 1.008849e-01 0.996 0 0
mTORC1-mediated signalling R-HSA-166208 1.105961e-01 0.956 0 0
Eukaryotic Translation Termination R-HSA-72764 8.854867e-02 1.053 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.624518e-02 1.017 0 0
Intraflagellar transport R-HSA-5620924 1.116901e-01 0.952 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.001997e-01 0.999 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.153053e-01 0.938 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.901327e-02 1.051 0 0
Diseases of DNA repair R-HSA-9675135 9.217799e-02 1.035 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.492377e-02 1.023 0 0
Specification of primordial germ cells R-HSA-9827857 9.894634e-02 1.005 0 0
Influenza Infection R-HSA-168255 8.992636e-02 1.046 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.006441e-01 0.997 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.153623e-01 0.938 0 0
Polo-like kinase mediated events R-HSA-156711 1.153623e-01 0.938 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.153623e-01 0.938 0 0
Platelet sensitization by LDL R-HSA-432142 1.153623e-01 0.938 0 0
Hemostasis R-HSA-109582 1.175012e-01 0.930 1 0
SARS-CoV-2-host interactions R-HSA-9705683 1.178004e-01 0.929 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.180620e-01 0.928 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.180620e-01 0.928 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.180620e-01 0.928 0 0
Signaling by Leptin R-HSA-2586552 1.180620e-01 0.928 0 0
Signal regulatory protein family interactions R-HSA-391160 1.185448e-01 0.926 0 0
Signaling by NTRKs R-HSA-166520 1.186381e-01 0.926 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.187790e-01 0.925 0 0
TBC/RABGAPs R-HSA-8854214 1.198367e-01 0.921 0 0
G alpha (z) signalling events R-HSA-418597 1.239613e-01 0.907 1 1
PLC beta mediated events R-HSA-112043 1.250446e-01 0.903 0 0
Sensory processing of sound R-HSA-9659379 1.258087e-01 0.900 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.258847e-01 0.900 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.260120e-01 0.900 0 0
Signaling by ALK R-HSA-201556 1.286668e-01 0.891 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.312733e-01 0.882 0 0
Selenocysteine synthesis R-HSA-2408557 1.312733e-01 0.882 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.315107e-01 0.881 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.330511e-01 0.876 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.330511e-01 0.876 0 0
Specification of the neural plate border R-HSA-9834899 1.330511e-01 0.876 0 0
The NLRP3 inflammasome R-HSA-844456 1.330511e-01 0.876 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.331567e-01 0.876 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.331567e-01 0.876 0 0
KIT mutants bind TKIs R-HSA-9669921 1.331567e-01 0.876 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.331567e-01 0.876 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.331567e-01 0.876 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.331567e-01 0.876 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.331567e-01 0.876 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.331567e-01 0.876 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.331567e-01 0.876 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.331567e-01 0.876 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.331567e-01 0.876 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.331567e-01 0.876 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.331567e-01 0.876 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.331567e-01 0.876 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.331567e-01 0.876 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.331567e-01 0.876 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.331567e-01 0.876 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.331567e-01 0.876 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.331567e-01 0.876 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.331567e-01 0.876 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.331567e-01 0.876 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.332741e-01 0.875 0 0
DARPP-32 events R-HSA-180024 1.332741e-01 0.875 0 0
Heme signaling R-HSA-9707616 1.352401e-01 0.869 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.354353e-01 0.868 0 0
DCC mediated attractive signaling R-HSA-418885 1.392127e-01 0.856 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.392127e-01 0.856 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.392127e-01 0.856 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.608323e-01 0.794 0 0
Axonal growth stimulation R-HSA-209563 1.608323e-01 0.794 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.608323e-01 0.794 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.608323e-01 0.794 0 0
CREB phosphorylation R-HSA-199920 1.396378e-01 0.855 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.734919e-01 0.761 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.734919e-01 0.761 0 0
Netrin mediated repulsion signals R-HSA-418886 1.734919e-01 0.761 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.734919e-01 0.761 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.734919e-01 0.761 0 0
Disinhibition of SNARE formation R-HSA-114516 1.734919e-01 0.761 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.093475e-01 0.679 0 0
Type I hemidesmosome assembly R-HSA-446107 2.093475e-01 0.679 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.093475e-01 0.679 0 0
Formation of annular gap junctions R-HSA-196025 2.093475e-01 0.679 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.695564e-01 0.771 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.695564e-01 0.771 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.695564e-01 0.771 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.695564e-01 0.771 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.613306e-01 0.792 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.613306e-01 0.792 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.977980e-01 0.704 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.977980e-01 0.704 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.977980e-01 0.704 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.519394e-01 0.818 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.519394e-01 0.818 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.519394e-01 0.818 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.519394e-01 0.818 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.847523e-01 0.733 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.847523e-01 0.733 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.847523e-01 0.733 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.847523e-01 0.733 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.847523e-01 0.733 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.719411e-01 0.765 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.719411e-01 0.765 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.093195e-01 0.679 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.486240e-01 0.828 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.486240e-01 0.828 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.929594e-01 0.715 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.929594e-01 0.715 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 1.929594e-01 0.715 0 0
Voltage gated Potassium channels R-HSA-1296072 1.835336e-01 0.736 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.693713e-01 0.771 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.458842e-01 0.836 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.458842e-01 0.836 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.699860e-01 0.770 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.984125e-01 0.702 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.984125e-01 0.702 0 0
Centrosome maturation R-HSA-380287 1.450675e-01 0.838 0 0
Viral mRNA Translation R-HSA-192823 1.478275e-01 0.830 0 0
Protein folding R-HSA-391251 1.511284e-01 0.821 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.407973e-01 0.851 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.993734e-01 0.700 0 0
Signaling by FGFR4 R-HSA-5654743 1.995176e-01 0.700 0 0
Formation of definitive endoderm R-HSA-9823730 1.519394e-01 0.818 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.993734e-01 0.700 0 0
Cellular response to heat stress R-HSA-3371556 1.667810e-01 0.778 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.977980e-01 0.704 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.827478e-01 0.738 0 0
TGFBR3 expression R-HSA-9839394 1.598566e-01 0.796 0 0
Signalling to ERKs R-HSA-187687 1.526467e-01 0.816 0 0
Signaling by ERBB2 R-HSA-1227986 1.819495e-01 0.740 0 0
Myogenesis R-HSA-525793 1.781709e-01 0.749 0 0
Nephrin family interactions R-HSA-373753 1.519394e-01 0.818 0 0
MAP2K and MAPK activation R-HSA-5674135 1.693713e-01 0.771 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.984125e-01 0.702 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.734919e-01 0.761 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.093195e-01 0.679 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.993734e-01 0.700 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.927321e-01 0.715 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.613306e-01 0.792 0 0
DAG and IP3 signaling R-HSA-1489509 1.437788e-01 0.842 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.526467e-01 0.816 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.847523e-01 0.733 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.093475e-01 0.679 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.977980e-01 0.704 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.495174e-01 0.825 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.003757e-01 0.698 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.608323e-01 0.794 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.093195e-01 0.679 0 0
Transmission across Chemical Synapses R-HSA-112315 1.404490e-01 0.852 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.835336e-01 0.736 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.424498e-01 0.846 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.810100e-01 0.742 0 0
Lipid particle organization R-HSA-8964572 1.396378e-01 0.855 0 0
Signaling by LTK R-HSA-9842663 1.977980e-01 0.704 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.993734e-01 0.700 0 0
PECAM1 interactions R-HSA-210990 1.428877e-01 0.845 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.695564e-01 0.771 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.551729e-01 0.809 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.841635e-01 0.735 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.734919e-01 0.761 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.093475e-01 0.679 0 0
Regulated Necrosis R-HSA-5218859 2.054422e-01 0.687 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.082659e-01 0.681 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.977980e-01 0.704 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.672364e-01 0.777 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.054422e-01 0.687 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.831741e-01 0.737 0 0
Sodium/Proton exchangers R-HSA-425986 2.093475e-01 0.679 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.551729e-01 0.809 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.927046e-01 0.715 0 0
NADE modulates death signalling R-HSA-205025 2.119468e-01 0.674 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.119468e-01 0.674 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.119468e-01 0.674 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.119468e-01 0.674 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.119468e-01 0.674 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.119468e-01 0.674 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.119468e-01 0.674 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.119468e-01 0.674 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.119468e-01 0.674 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.148889e-01 0.668 0 0
Cyclin D associated events in G1 R-HSA-69231 2.153988e-01 0.667 0 0
G1 Phase R-HSA-69236 2.153988e-01 0.667 0 0
Amine ligand-binding receptors R-HSA-375280 2.153988e-01 0.667 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.176851e-01 0.662 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.176851e-01 0.662 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.176851e-01 0.662 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.184870e-01 0.661 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.220189e-01 0.654 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.273334e-01 0.643 0 0
Formation of axial mesoderm R-HSA-9796292 2.273334e-01 0.643 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.273334e-01 0.643 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.273334e-01 0.643 0 0
Signaling by FGFR3 R-HSA-5654741 2.317692e-01 0.635 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.317692e-01 0.635 0 0
Signaling by Hedgehog R-HSA-5358351 2.317757e-01 0.635 0 0
Diseases of Immune System R-HSA-5260271 2.344635e-01 0.630 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.344635e-01 0.630 0 0
Apoptotic factor-mediated response R-HSA-111471 2.348656e-01 0.629 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.365971e-01 0.626 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.365971e-01 0.626 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.378391e-01 0.624 0 0
Ion channel transport R-HSA-983712 2.378712e-01 0.624 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.388834e-01 0.622 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.485894e-01 0.605 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.485894e-01 0.605 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.485894e-01 0.605 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.485894e-01 0.605 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.485894e-01 0.605 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.485894e-01 0.605 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.485894e-01 0.605 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.486563e-01 0.458 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.486563e-01 0.458 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.486563e-01 0.458 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.486563e-01 0.458 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.486563e-01 0.458 0 0
Mitochondrial transcription initiation R-HSA-163282 3.486563e-01 0.458 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.486563e-01 0.458 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.486563e-01 0.458 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.486563e-01 0.458 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.486563e-01 0.458 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.486563e-01 0.458 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.486563e-01 0.458 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.486563e-01 0.458 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.486563e-01 0.458 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.486563e-01 0.458 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.486563e-01 0.458 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.486563e-01 0.458 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.486563e-01 0.458 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.486563e-01 0.458 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.486563e-01 0.458 0 0
Intestinal infectious diseases R-HSA-8942233 3.486563e-01 0.458 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.486563e-01 0.458 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.486563e-01 0.458 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.486563e-01 0.458 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.486563e-01 0.458 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.643325e-01 0.578 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.643325e-01 0.578 0 0
IRS activation R-HSA-74713 2.643325e-01 0.578 0 0
G2 Phase R-HSA-68911 2.643325e-01 0.578 0 0
ARMS-mediated activation R-HSA-170984 2.466371e-01 0.608 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.466371e-01 0.608 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.466371e-01 0.608 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.167452e-01 0.499 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.167452e-01 0.499 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.167452e-01 0.499 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.167452e-01 0.499 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.167452e-01 0.499 0 0
Signaling by MAPK mutants R-HSA-9652817 3.167452e-01 0.499 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.167452e-01 0.499 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.354021e-01 0.361 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.354021e-01 0.361 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.354021e-01 0.361 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.354021e-01 0.361 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.354021e-01 0.361 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.354021e-01 0.361 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.354021e-01 0.361 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.354021e-01 0.361 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.354021e-01 0.361 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.848332e-01 0.545 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.848332e-01 0.545 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.848332e-01 0.545 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.578825e-01 0.589 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.682492e-01 0.434 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.682492e-01 0.434 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.682492e-01 0.434 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.682492e-01 0.434 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.234581e-01 0.490 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.234581e-01 0.490 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.234581e-01 0.490 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.891715e-01 0.539 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.891715e-01 0.539 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.891715e-01 0.539 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.610318e-01 0.583 0 0
Deadenylation of mRNA R-HSA-429947 2.610318e-01 0.583 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.882126e-01 0.540 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.620887e-01 0.441 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.620887e-01 0.441 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.181574e-01 0.379 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.181574e-01 0.379 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.181574e-01 0.379 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.181574e-01 0.379 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.181574e-01 0.379 0 0
SOS-mediated signalling R-HSA-112412 4.181574e-01 0.379 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.181574e-01 0.379 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.850117e-01 0.545 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.156741e-01 0.501 0 0
EGFR downregulation R-HSA-182971 2.807486e-01 0.552 0 0
Downstream signal transduction R-HSA-186763 2.807486e-01 0.552 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.003580e-01 0.398 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.003580e-01 0.398 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.028848e-01 0.519 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.658159e-01 0.575 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.849349e-01 0.415 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.659816e-01 0.332 0 0
RSK activation R-HSA-444257 4.659816e-01 0.332 0 0
Activation of RAS in B cells R-HSA-1169092 4.659816e-01 0.332 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.591748e-01 0.445 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.379537e-01 0.359 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.167297e-01 0.380 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.992751e-01 0.399 0 0
Signaling by NOTCH4 R-HSA-9013694 2.886563e-01 0.540 0 0
HSF1-dependent transactivation R-HSA-3371571 3.379058e-01 0.471 0 0
Activation of the pre-replicative complex R-HSA-68962 4.093412e-01 0.388 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.093412e-01 0.388 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.270570e-01 0.370 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.270570e-01 0.370 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.746165e-01 0.324 0 0
cGMP effects R-HSA-418457 4.746165e-01 0.324 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.545766e-01 0.342 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.545766e-01 0.342 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.789833e-01 0.320 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.789833e-01 0.320 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.817191e-01 0.317 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.476259e-01 0.349 0 0
Neutrophil degranulation R-HSA-6798695 2.578961e-01 0.589 0 0
Stabilization of p53 R-HSA-69541 4.850768e-01 0.314 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.659558e-01 0.332 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.842574e-01 0.415 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.093412e-01 0.388 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.430536e-01 0.465 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.430536e-01 0.465 0 0
IGF1R signaling cascade R-HSA-2428924 3.362512e-01 0.473 0 0
Adipogenesis R-HSA-9843745 2.836720e-01 0.547 0 0
Circadian clock R-HSA-9909396 4.552134e-01 0.342 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.167297e-01 0.380 0 0
p75NTR signals via NF-kB R-HSA-193639 2.891715e-01 0.539 0 0
Signaling by SCF-KIT R-HSA-1433557 3.089381e-01 0.510 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.379537e-01 0.359 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.167297e-01 0.380 0 0
Ribosome-associated quality control R-HSA-9948299 2.986994e-01 0.525 0 0
Prolonged ERK activation events R-HSA-169893 3.209380e-01 0.494 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.240381e-01 0.489 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.620887e-01 0.441 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.529351e-01 0.452 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.453253e-01 0.351 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.015455e-01 0.396 0 0
Activation of GABAB receptors R-HSA-991365 2.897738e-01 0.538 0 0
Signaling by FGFR1 R-HSA-5654736 3.111478e-01 0.507 0 0
Developmental Cell Lineages R-HSA-9734767 3.632670e-01 0.440 0 0
Signal attenuation R-HSA-74749 2.848332e-01 0.545 0 0
Integration of provirus R-HSA-162592 3.620887e-01 0.441 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.529351e-01 0.452 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.481337e-01 0.349 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.789833e-01 0.320 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.591204e-01 0.338 0 0
Frs2-mediated activation R-HSA-170968 4.379537e-01 0.359 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.469751e-01 0.350 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.530144e-01 0.452 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.722192e-01 0.326 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.466371e-01 0.608 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.659816e-01 0.332 0 0
GAB1 signalosome R-HSA-180292 4.167297e-01 0.380 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.722192e-01 0.326 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.167452e-01 0.499 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.181574e-01 0.379 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.094396e-01 0.509 0 0
Interleukin-2 family signaling R-HSA-451927 3.589837e-01 0.445 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.709685e-01 0.431 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.234581e-01 0.490 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.028848e-01 0.519 0 0
GABA B receptor activation R-HSA-977444 2.897738e-01 0.538 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.481337e-01 0.349 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.434411e-01 0.464 0 0
PTEN Regulation R-HSA-6807070 4.684071e-01 0.329 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.094396e-01 0.509 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.341988e-01 0.476 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.466371e-01 0.608 0 0
NADPH regeneration R-HSA-389542 3.682492e-01 0.434 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.003580e-01 0.398 0 0
Regulation by c-FLIP R-HSA-3371378 4.659816e-01 0.332 0 0
GABA receptor activation R-HSA-977443 2.712020e-01 0.567 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.992751e-01 0.399 0 0
Hedgehog 'off' state R-HSA-5610787 2.456178e-01 0.610 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.481337e-01 0.349 0 0
Cellular response to starvation R-HSA-9711097 3.097010e-01 0.509 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.636900e-01 0.439 0 0
Interferon gamma signaling R-HSA-877300 4.704134e-01 0.328 0 0
Neurexins and neuroligins R-HSA-6794361 3.564948e-01 0.448 0 0
PERK regulates gene expression R-HSA-381042 3.939368e-01 0.405 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.958372e-01 0.402 0 0
HIV Life Cycle R-HSA-162587 2.994794e-01 0.524 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.762615e-01 0.322 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.801641e-01 0.420 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.209380e-01 0.494 0 0
Interleukin-6 signaling R-HSA-1059683 4.379537e-01 0.359 0 0
S Phase R-HSA-69242 2.754715e-01 0.560 0 0
HIV Infection R-HSA-162906 4.751626e-01 0.323 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.643325e-01 0.578 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.167452e-01 0.499 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.354021e-01 0.361 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.578825e-01 0.589 0 0
Abacavir transmembrane transport R-HSA-2161517 3.682492e-01 0.434 0 0
Activation of SMO R-HSA-5635838 3.209380e-01 0.494 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.620887e-01 0.441 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.181574e-01 0.379 0 0
Tight junction interactions R-HSA-420029 2.850117e-01 0.545 0 0
Dimerization of procaspase-8 R-HSA-69416 4.659816e-01 0.332 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.659816e-01 0.332 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.659816e-01 0.332 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.659816e-01 0.332 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.379537e-01 0.359 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.480265e-01 0.458 0 0
Cellular response to chemical stress R-HSA-9711123 4.067342e-01 0.391 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.480812e-01 0.458 0 0
GPVI-mediated activation cascade R-HSA-114604 4.169061e-01 0.380 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.481337e-01 0.349 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.842574e-01 0.415 0 0
NGF-stimulated transcription R-HSA-9031628 2.834063e-01 0.548 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.939368e-01 0.405 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.722192e-01 0.326 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.541070e-01 0.451 0 0
Signaling by TGFB family members R-HSA-9006936 4.818102e-01 0.317 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.643325e-01 0.578 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.167452e-01 0.499 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.891715e-01 0.539 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.620887e-01 0.441 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.659816e-01 0.332 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.746165e-01 0.324 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.836366e-01 0.315 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.823960e-01 0.417 0 0
Cardiogenesis R-HSA-9733709 3.253581e-01 0.488 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.528756e-01 0.452 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.528756e-01 0.452 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.904967e-01 0.408 0 0
mRNA Editing R-HSA-75072 2.466371e-01 0.608 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.904967e-01 0.408 0 0
UCH proteinases R-HSA-5689603 3.185032e-01 0.497 0 0
Signal transduction by L1 R-HSA-445144 4.789833e-01 0.320 0 0
rRNA processing R-HSA-72312 3.913556e-01 0.407 0 0
Rab regulation of trafficking R-HSA-9007101 4.136938e-01 0.383 0 0
Interleukin-7 signaling R-HSA-1266695 2.850117e-01 0.545 0 0
Interleukin-9 signaling R-HSA-8985947 4.659816e-01 0.332 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.011590e-01 0.521 0 0
G-protein beta:gamma signalling R-HSA-397795 3.253581e-01 0.488 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.011590e-01 0.521 0 0
Signaling by PTK6 R-HSA-8848021 3.196547e-01 0.495 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.196547e-01 0.495 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.011590e-01 0.521 0 0
Host Interactions of HIV factors R-HSA-162909 3.322658e-01 0.479 0 0
Platelet homeostasis R-HSA-418346 3.321069e-01 0.479 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.485894e-01 0.605 0 0
Inhibition of PKR R-HSA-169131 2.485894e-01 0.605 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.486563e-01 0.458 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.643325e-01 0.578 0 0
Unwinding of DNA R-HSA-176974 2.466371e-01 0.608 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.466371e-01 0.608 0 0
Formation of the Editosome R-HSA-75094 3.167452e-01 0.499 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.354021e-01 0.361 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.354021e-01 0.361 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.354021e-01 0.361 0 0
C6 deamination of adenosine R-HSA-75102 4.354021e-01 0.361 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.848332e-01 0.545 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.682492e-01 0.434 0 0
Negative regulation of FLT3 R-HSA-9706369 3.209380e-01 0.494 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.209380e-01 0.494 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.181574e-01 0.379 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.181574e-01 0.379 0 0
Regulation of IFNG signaling R-HSA-877312 4.003580e-01 0.398 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.434411e-01 0.464 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.659816e-01 0.332 0 0
Co-stimulation by ICOS R-HSA-9927354 4.659816e-01 0.332 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.591748e-01 0.445 0 0
Cilium Assembly R-HSA-5617833 3.056604e-01 0.515 0 0
Signaling by ERBB4 R-HSA-1236394 3.916447e-01 0.407 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.094396e-01 0.509 0 0
Ion transport by P-type ATPases R-HSA-936837 4.530568e-01 0.344 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.834063e-01 0.548 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.337114e-01 0.477 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.659816e-01 0.332 0 0
tRNA processing in the nucleus R-HSA-6784531 3.032588e-01 0.518 0 0
Interleukin-1 family signaling R-HSA-446652 4.697856e-01 0.328 0 0
Formation of the nephric duct R-HSA-9830364 2.850117e-01 0.545 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.713573e-01 0.430 0 0
RUNX2 regulates bone development R-HSA-8941326 4.169061e-01 0.380 0 0
RAB geranylgeranylation R-HSA-8873719 2.712020e-01 0.567 0 0
Syndecan interactions R-HSA-3000170 3.992751e-01 0.399 0 0
Protein hydroxylation R-HSA-9629569 4.789833e-01 0.320 0 0
Signaling by NOTCH3 R-HSA-9012852 4.128867e-01 0.384 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.093412e-01 0.388 0 0
Inflammasomes R-HSA-622312 3.591748e-01 0.445 0 0
Other interleukin signaling R-HSA-449836 2.612203e-01 0.583 0 0
PI Metabolism R-HSA-1483255 4.486571e-01 0.348 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.643325e-01 0.578 0 0
DSCAM interactions R-HSA-376172 4.354021e-01 0.361 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.848332e-01 0.545 0 0
Formation of the anterior neural plate R-HSA-9823739 2.891715e-01 0.539 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.620887e-01 0.441 0 0
Maturation of nucleoprotein R-HSA-9683610 4.379537e-01 0.359 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.271092e-01 0.485 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.341988e-01 0.476 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.156741e-01 0.501 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.860381e-01 0.413 0 0
Glucose metabolism R-HSA-70326 2.521201e-01 0.598 0 0
Co-inhibition by BTLA R-HSA-9927353 2.643325e-01 0.578 0 0
NrCAM interactions R-HSA-447038 2.643325e-01 0.578 0 0
Regulation of PTEN localization R-HSA-8948747 4.181574e-01 0.379 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.253581e-01 0.488 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.850768e-01 0.314 0 0
IRE1alpha activates chaperones R-HSA-381070 4.754100e-01 0.323 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.612203e-01 0.583 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.167452e-01 0.499 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.167452e-01 0.499 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.891715e-01 0.539 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.485890e-01 0.605 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.944627e-01 0.404 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.167297e-01 0.380 0 0
Growth hormone receptor signaling R-HSA-982772 3.992751e-01 0.399 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.709685e-01 0.431 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.167297e-01 0.380 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.862104e-01 0.313 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.871334e-01 0.312 0 0
Signaling by FGFR2 R-HSA-5654738 4.896295e-01 0.310 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.900725e-01 0.310 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.046272e-01 0.297 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.073296e-01 0.295 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.073296e-01 0.295 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.073296e-01 0.295 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.073296e-01 0.295 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.083816e-01 0.294 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.091367e-01 0.293 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.091367e-01 0.293 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.091367e-01 0.293 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.091367e-01 0.293 0 0
Signalling to RAS R-HSA-167044 5.091367e-01 0.293 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.091367e-01 0.293 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.101360e-01 0.292 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.101360e-01 0.292 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.101360e-01 0.292 0 0
p38MAPK events R-HSA-171007 5.101360e-01 0.292 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.101360e-01 0.292 0 0
Protein methylation R-HSA-8876725 5.101360e-01 0.292 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.101360e-01 0.292 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.105995e-01 0.292 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.105995e-01 0.292 0 0
MET activates PTPN11 R-HSA-8865999 5.105995e-01 0.292 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.105995e-01 0.292 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.105995e-01 0.292 0 0
Classical Kir channels R-HSA-1296053 5.105995e-01 0.292 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.105995e-01 0.292 0 0
Invadopodia formation R-HSA-8941237 5.105995e-01 0.292 0 0
MET interacts with TNS proteins R-HSA-8875513 5.105995e-01 0.292 0 0
Intracellular oxygen transport R-HSA-8981607 5.105995e-01 0.292 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.105995e-01 0.292 0 0
Histamine receptors R-HSA-390650 5.105995e-01 0.292 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.105995e-01 0.292 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.105995e-01 0.292 0 0
WNT mediated activation of DVL R-HSA-201688 5.113917e-01 0.291 0 0
CASP8 activity is inhibited R-HSA-5218900 5.113917e-01 0.291 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.113917e-01 0.291 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.113917e-01 0.291 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.113917e-01 0.291 0 0
Interleukin-1 processing R-HSA-448706 5.113917e-01 0.291 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.113917e-01 0.291 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.113917e-01 0.291 0 0
Lipophagy R-HSA-9613354 5.113917e-01 0.291 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.246191e-01 0.280 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.274123e-01 0.278 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.292466e-01 0.276 0 0
Vesicle-mediated transport R-HSA-5653656 5.304303e-01 0.275 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.313256e-01 0.275 0 0
Mitophagy R-HSA-5205647 5.315287e-01 0.274 0 0
Signaling by NOTCH2 R-HSA-1980145 5.315287e-01 0.274 0 0
Telomere Extension By Telomerase R-HSA-171319 5.344735e-01 0.272 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.344735e-01 0.272 0 0
G alpha (s) signalling events R-HSA-418555 5.375338e-01 0.270 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.384736e-01 0.269 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.384736e-01 0.269 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.384736e-01 0.269 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.384736e-01 0.269 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.443466e-01 0.264 0 0
Killing mechanisms R-HSA-9664420 5.443466e-01 0.264 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.443466e-01 0.264 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.443466e-01 0.264 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.443466e-01 0.264 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.467723e-01 0.262 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.507754e-01 0.259 0 0
2-LTR circle formation R-HSA-164843 5.541826e-01 0.256 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.541826e-01 0.256 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.541826e-01 0.256 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.541826e-01 0.256 0 0
PI3K/AKT activation R-HSA-198203 5.541826e-01 0.256 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.541826e-01 0.256 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.547698e-01 0.256 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.547698e-01 0.256 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.577037e-01 0.254 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.577037e-01 0.254 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.603868e-01 0.252 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.604330e-01 0.251 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.636044e-01 0.249 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.636044e-01 0.249 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.641242e-01 0.249 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.668941e-01 0.246 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.668941e-01 0.246 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.668941e-01 0.246 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.668941e-01 0.246 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.668941e-01 0.246 0 0
DNA Damage Bypass R-HSA-73893 5.673509e-01 0.246 0 0
Degradation of CDH1 R-HSA-9766229 5.673509e-01 0.246 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.686888e-01 0.245 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.700119e-01 0.244 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.738567e-01 0.241 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.738567e-01 0.241 0 0
HCN channels R-HSA-1296061 5.757853e-01 0.240 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.757853e-01 0.240 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.757853e-01 0.240 0 0
Nucleotide catabolism defects R-HSA-9735786 5.757853e-01 0.240 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.757853e-01 0.240 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.757853e-01 0.240 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.757853e-01 0.240 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.757853e-01 0.240 0 0
Transmission across Electrical Synapses R-HSA-112307 5.757853e-01 0.240 0 0
Alanine metabolism R-HSA-8964540 5.757853e-01 0.240 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.757853e-01 0.240 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.757853e-01 0.240 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.757853e-01 0.240 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.757853e-01 0.240 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.760244e-01 0.240 0 0
Phase 2 - plateau phase R-HSA-5576893 5.771231e-01 0.239 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.771231e-01 0.239 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.771231e-01 0.239 0 0
Disorders of Developmental Biology R-HSA-9675151 5.771231e-01 0.239 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.774636e-01 0.238 0 0
FLT3 signaling in disease R-HSA-9682385 5.774636e-01 0.238 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.779272e-01 0.238 0 0
Leishmania infection R-HSA-9658195 5.827631e-01 0.235 0 0
Parasitic Infection Pathways R-HSA-9824443 5.827631e-01 0.235 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.846410e-01 0.233 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.846410e-01 0.233 0 0
PI3K Cascade R-HSA-109704 5.867481e-01 0.232 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.942463e-01 0.226 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.942463e-01 0.226 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.942463e-01 0.226 0 0
Formation of the posterior neural plate R-HSA-9832991 5.942463e-01 0.226 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.942463e-01 0.226 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.942463e-01 0.226 0 0
Synthesis of PI R-HSA-1483226 5.942463e-01 0.226 0 0
Prostanoid ligand receptors R-HSA-391908 5.942463e-01 0.226 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.943175e-01 0.226 0 0
Mitochondrial biogenesis R-HSA-1592230 5.976519e-01 0.224 0 0
Inositol phosphate metabolism R-HSA-1483249 6.003114e-01 0.222 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.004263e-01 0.222 0 0
Integration of energy metabolism R-HSA-163685 6.026363e-01 0.220 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.032079e-01 0.220 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.070648e-01 0.217 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.083760e-01 0.216 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.083760e-01 0.216 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.083760e-01 0.216 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.083760e-01 0.216 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.083760e-01 0.216 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.083760e-01 0.216 0 0
Budding and maturation of HIV virion R-HSA-162588 6.085932e-01 0.216 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.085932e-01 0.216 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.132723e-01 0.212 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.176125e-01 0.209 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.183298e-01 0.209 0 0
G1/S Transition R-HSA-69206 6.197364e-01 0.208 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.206808e-01 0.207 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.206808e-01 0.207 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.206808e-01 0.207 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.315503e-01 0.200 0 0
NF-kB is activated and signals survival R-HSA-209560 6.315503e-01 0.200 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.315503e-01 0.200 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.315503e-01 0.200 0 0
Sodium/Calcium exchangers R-HSA-425561 6.315503e-01 0.200 0 0
DNA strand elongation R-HSA-69190 6.317266e-01 0.199 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.321433e-01 0.199 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.321433e-01 0.199 0 0
Activation of AMPA receptors R-HSA-399710 6.322919e-01 0.199 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.322919e-01 0.199 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.322919e-01 0.199 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.322919e-01 0.199 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.322919e-01 0.199 0 0
Activation of AKT2 R-HSA-165158 6.322919e-01 0.199 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.322919e-01 0.199 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.322919e-01 0.199 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.322919e-01 0.199 0 0
Suppression of autophagy R-HSA-9636569 6.322919e-01 0.199 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.322919e-01 0.199 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.322919e-01 0.199 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.322919e-01 0.199 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.322919e-01 0.199 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.322919e-01 0.199 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.380469e-01 0.195 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.380469e-01 0.195 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.380469e-01 0.195 0 0
PKA activation in glucagon signalling R-HSA-164378 6.380469e-01 0.195 0 0
Mismatch Repair R-HSA-5358508 6.380469e-01 0.195 0 0
PKA activation R-HSA-163615 6.380469e-01 0.195 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.380469e-01 0.195 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.380469e-01 0.195 0 0
Tie2 Signaling R-HSA-210993 6.380469e-01 0.195 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.380469e-01 0.195 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.384493e-01 0.195 0 0
Viral Infection Pathways R-HSA-9824446 6.397607e-01 0.194 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.402794e-01 0.194 0 0
Smooth Muscle Contraction R-HSA-445355 6.422721e-01 0.192 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.459375e-01 0.190 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.459375e-01 0.190 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.459375e-01 0.190 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.459375e-01 0.190 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.466968e-01 0.189 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.509623e-01 0.186 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.511272e-01 0.186 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.511272e-01 0.186 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.511272e-01 0.186 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.516128e-01 0.186 0 0
MAP kinase activation R-HSA-450294 6.516128e-01 0.186 0 0
Nuclear RNA decay R-HSA-9930044 6.540056e-01 0.184 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.540056e-01 0.184 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.594281e-01 0.181 0 0
Generation of second messenger molecules R-HSA-202433 6.619014e-01 0.179 0 0
Regulation of signaling by CBL R-HSA-912631 6.661045e-01 0.176 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.661045e-01 0.176 0 0
Maturation of nucleoprotein R-HSA-9694631 6.661045e-01 0.176 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.661188e-01 0.176 0 0
Interleukin-15 signaling R-HSA-8983432 6.661188e-01 0.176 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.661188e-01 0.176 0 0
Repression of WNT target genes R-HSA-4641265 6.661188e-01 0.176 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.661188e-01 0.176 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.661188e-01 0.176 0 0
Estrogen biosynthesis R-HSA-193144 6.661188e-01 0.176 0 0
Disorders of Nervous System Development R-HSA-9697154 6.661188e-01 0.176 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.661188e-01 0.176 0 0
Pervasive developmental disorders R-HSA-9005895 6.661188e-01 0.176 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.661188e-01 0.176 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.661188e-01 0.176 0 0
OAS antiviral response R-HSA-8983711 6.661188e-01 0.176 0 0
Signaling by PDGF R-HSA-186797 6.679510e-01 0.175 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.695167e-01 0.174 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.700560e-01 0.174 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.700560e-01 0.174 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.700560e-01 0.174 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.754036e-01 0.170 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.756323e-01 0.170 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.761392e-01 0.170 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.768243e-01 0.170 0 0
Selenoamino acid metabolism R-HSA-2408522 6.806927e-01 0.167 0 0
TRAIL signaling R-HSA-75158 6.812745e-01 0.167 0 0
Plus-strand DNA synthesis R-HSA-164525 6.812745e-01 0.167 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.812745e-01 0.167 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.812745e-01 0.167 0 0
PDE3B signalling R-HSA-165160 6.812745e-01 0.167 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.812745e-01 0.167 0 0
PKB-mediated events R-HSA-109703 6.812745e-01 0.167 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.812745e-01 0.167 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.812745e-01 0.167 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.812745e-01 0.167 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.812745e-01 0.167 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.812745e-01 0.167 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.812745e-01 0.167 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.812745e-01 0.167 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.812745e-01 0.167 0 0
Synthesis of PS R-HSA-1483101 6.812745e-01 0.167 0 0
Ceramide signalling R-HSA-193681 6.812745e-01 0.167 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.812745e-01 0.167 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.812745e-01 0.167 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.812745e-01 0.167 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.812745e-01 0.167 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.812745e-01 0.167 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.812745e-01 0.167 0 0
Metal ion SLC transporters R-HSA-425410 6.872941e-01 0.163 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.898311e-01 0.161 0 0
Signaling by FGFR R-HSA-190236 6.903335e-01 0.161 0 0
Hedgehog 'on' state R-HSA-5632684 6.905411e-01 0.161 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.925402e-01 0.160 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.925402e-01 0.160 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.930176e-01 0.159 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.930176e-01 0.159 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.930176e-01 0.159 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.930176e-01 0.159 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.930176e-01 0.159 0 0
TNF signaling R-HSA-75893 6.933078e-01 0.159 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.959027e-01 0.157 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.980186e-01 0.156 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.980186e-01 0.156 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.980186e-01 0.156 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.980186e-01 0.156 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.980186e-01 0.156 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.980186e-01 0.156 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.980186e-01 0.156 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.980186e-01 0.156 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.980186e-01 0.156 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.980186e-01 0.156 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.980186e-01 0.156 0 0
Insulin receptor signalling cascade R-HSA-74751 6.992306e-01 0.155 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.999031e-01 0.155 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.050231e-01 0.152 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.091265e-01 0.149 0 0
IRS-mediated signalling R-HSA-112399 7.092469e-01 0.149 0 0
Regulation of CDH1 Function R-HSA-9764561 7.092469e-01 0.149 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.148158e-01 0.146 0 0
HIV elongation arrest and recovery R-HSA-167287 7.148158e-01 0.146 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.148158e-01 0.146 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.148158e-01 0.146 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.173645e-01 0.144 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.173645e-01 0.144 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.173645e-01 0.144 0 0
Basigin interactions R-HSA-210991 7.173645e-01 0.144 0 0
Ca2+ pathway R-HSA-4086398 7.190705e-01 0.143 0 0
Signaling by LTK in cancer R-HSA-9842640 7.237346e-01 0.140 0 0
STAT5 Activation R-HSA-9645135 7.237346e-01 0.140 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.237346e-01 0.140 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.237346e-01 0.140 0 0
Uncoating of the HIV Virion R-HSA-162585 7.237346e-01 0.140 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.237346e-01 0.140 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.237346e-01 0.140 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.237346e-01 0.140 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.237346e-01 0.140 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.237346e-01 0.140 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.237346e-01 0.140 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.237346e-01 0.140 0 0
Nef and signal transduction R-HSA-164944 7.237346e-01 0.140 0 0
VLDL assembly R-HSA-8866423 7.237346e-01 0.140 0 0
Neurofascin interactions R-HSA-447043 7.237346e-01 0.140 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.246337e-01 0.140 0 0
Removal of the Flap Intermediate R-HSA-69166 7.273472e-01 0.138 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.273472e-01 0.138 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.273472e-01 0.138 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.273472e-01 0.138 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.273472e-01 0.138 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.273472e-01 0.138 0 0
Prolactin receptor signaling R-HSA-1170546 7.273472e-01 0.138 0 0
HDL assembly R-HSA-8963896 7.273472e-01 0.138 0 0
Zinc transporters R-HSA-435354 7.273472e-01 0.138 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.273472e-01 0.138 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.326772e-01 0.135 0 0
G1/S-Specific Transcription R-HSA-69205 7.341700e-01 0.134 0 0
Toll-like Receptor Cascades R-HSA-168898 7.346539e-01 0.134 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.349230e-01 0.134 0 0
Signaling by Erythropoietin R-HSA-9006335 7.354538e-01 0.133 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.354538e-01 0.133 0 0
Late endosomal microautophagy R-HSA-9615710 7.354538e-01 0.133 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.354538e-01 0.133 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.354538e-01 0.133 0 0
Extension of Telomeres R-HSA-180786 7.394628e-01 0.131 0 0
SARS-CoV Infections R-HSA-9679506 7.394764e-01 0.131 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.406038e-01 0.130 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.493254e-01 0.125 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.519379e-01 0.124 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.520781e-01 0.124 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.520781e-01 0.124 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.520781e-01 0.124 0 0
Erythropoietin activates RAS R-HSA-9027284 7.542233e-01 0.123 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.542233e-01 0.123 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.542233e-01 0.123 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.542233e-01 0.123 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.542233e-01 0.123 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.542233e-01 0.123 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.542233e-01 0.123 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.542233e-01 0.123 0 0
DAP12 signaling R-HSA-2424491 7.549442e-01 0.122 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.549442e-01 0.122 0 0
Transcription of the HIV genome R-HSA-167172 7.559550e-01 0.122 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.605403e-01 0.119 0 0
CHL1 interactions R-HSA-447041 7.605403e-01 0.119 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.605403e-01 0.119 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.605403e-01 0.119 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.605403e-01 0.119 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.605403e-01 0.119 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.605403e-01 0.119 0 0
Recycling of eIF2:GDP R-HSA-72731 7.605403e-01 0.119 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.605403e-01 0.119 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.605403e-01 0.119 0 0
LDL remodeling R-HSA-8964041 7.605403e-01 0.119 0 0
FGFR2 alternative splicing R-HSA-6803529 7.622972e-01 0.118 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.622972e-01 0.118 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.622972e-01 0.118 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.622972e-01 0.118 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.666730e-01 0.115 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.666730e-01 0.115 0 0
MET promotes cell motility R-HSA-8875878 7.688047e-01 0.114 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.688047e-01 0.114 0 0
Cargo concentration in the ER R-HSA-5694530 7.733067e-01 0.112 0 0
Regulation of insulin secretion R-HSA-422356 7.781805e-01 0.109 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.787799e-01 0.109 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.787799e-01 0.109 0 0
Atorvastatin ADME R-HSA-9754706 7.787799e-01 0.109 0 0
Regulation of BACH1 activity R-HSA-9708530 7.787799e-01 0.109 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.787799e-01 0.109 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.805916e-01 0.108 0 0
Interleukin-17 signaling R-HSA-448424 7.813403e-01 0.107 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.818265e-01 0.107 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.824937e-01 0.107 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.847836e-01 0.105 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.924444e-01 0.101 0 0
Minus-strand DNA synthesis R-HSA-164516 7.924444e-01 0.101 0 0
phospho-PLA2 pathway R-HSA-111995 7.924444e-01 0.101 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.924444e-01 0.101 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.924444e-01 0.101 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.924444e-01 0.101 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.924444e-01 0.101 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.924444e-01 0.101 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.924444e-01 0.101 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.924444e-01 0.101 0 0
Alpha-defensins R-HSA-1462054 7.924444e-01 0.101 0 0
Interleukin-23 signaling R-HSA-9020933 7.924444e-01 0.101 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.940143e-01 0.100 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.952509e-01 0.099 0 0
Parasite infection R-HSA-9664407 7.952509e-01 0.099 0 0
Leishmania phagocytosis R-HSA-9664417 7.952509e-01 0.099 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.959847e-01 0.099 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.981264e-01 0.098 0 0
Platelet degranulation R-HSA-114608 7.983070e-01 0.098 0 0
HIV Transcription Elongation R-HSA-167169 7.998920e-01 0.097 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.998920e-01 0.097 0 0
Attenuation phase R-HSA-3371568 7.998920e-01 0.097 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.998920e-01 0.097 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.998920e-01 0.097 0 0
Glycogen metabolism R-HSA-8982491 7.998920e-01 0.097 0 0
PPARA activates gene expression R-HSA-1989781 8.009833e-01 0.096 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.011578e-01 0.096 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.011578e-01 0.096 0 0
Passive transport by Aquaporins R-HSA-432047 8.011578e-01 0.096 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.011578e-01 0.096 0 0
Synthesis of PG R-HSA-1483148 8.011578e-01 0.096 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.012502e-01 0.096 0 0
Interleukin-6 family signaling R-HSA-6783589 8.012502e-01 0.096 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.012502e-01 0.096 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.012502e-01 0.096 0 0
GPCR downstream signalling R-HSA-388396 8.085131e-01 0.092 1 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.141508e-01 0.089 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.162475e-01 0.088 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.163619e-01 0.088 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.186292e-01 0.087 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.186292e-01 0.087 0 0
G protein gated Potassium channels R-HSA-1296059 8.186292e-01 0.087 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.186292e-01 0.087 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.200994e-01 0.086 0 0
Interleukin-21 signaling R-HSA-9020958 8.200994e-01 0.086 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.200994e-01 0.086 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.200994e-01 0.086 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.200994e-01 0.086 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.200994e-01 0.086 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.200994e-01 0.086 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.200994e-01 0.086 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.215016e-01 0.085 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.215016e-01 0.085 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.215016e-01 0.085 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.215016e-01 0.085 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.215016e-01 0.085 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.219139e-01 0.085 0 0
Heme degradation R-HSA-189483 8.219139e-01 0.085 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.219139e-01 0.085 0 0
TCR signaling R-HSA-202403 8.271902e-01 0.082 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.275837e-01 0.082 0 0
Intra-Golgi traffic R-HSA-6811438 8.275837e-01 0.082 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.275837e-01 0.082 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.302556e-01 0.081 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.346971e-01 0.078 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.360736e-01 0.078 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.360736e-01 0.078 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.360736e-01 0.078 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.362732e-01 0.078 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.399559e-01 0.076 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.399559e-01 0.076 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.399559e-01 0.076 0 0
Regulation of beta-cell development R-HSA-186712 8.411684e-01 0.075 0 0
Binding and entry of HIV virion R-HSA-173107 8.440710e-01 0.074 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.440710e-01 0.074 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.440710e-01 0.074 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.440710e-01 0.074 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.440710e-01 0.074 0 0
Interleukin-27 signaling R-HSA-9020956 8.440710e-01 0.074 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.440710e-01 0.074 0 0
Maturation of spike protein R-HSA-9683686 8.440710e-01 0.074 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.440710e-01 0.074 0 0
Pexophagy R-HSA-9664873 8.440710e-01 0.074 0 0
Formation of apoptosome R-HSA-111458 8.440710e-01 0.074 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.440710e-01 0.074 0 0
Josephin domain DUBs R-HSA-5689877 8.440710e-01 0.074 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.440710e-01 0.074 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.440710e-01 0.074 0 0
The phototransduction cascade R-HSA-2514856 8.455986e-01 0.073 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.495227e-01 0.071 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.495227e-01 0.071 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.513879e-01 0.070 0 0
Orc1 removal from chromatin R-HSA-68949 8.563398e-01 0.067 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.566630e-01 0.067 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.566630e-01 0.067 0 0
Translesion Synthesis by POLH R-HSA-110320 8.566630e-01 0.067 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.566630e-01 0.067 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.613055e-01 0.065 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.615711e-01 0.065 0 0
HSF1 activation R-HSA-3371511 8.615711e-01 0.065 0 0
RNA Polymerase III Transcription R-HSA-74158 8.615711e-01 0.065 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.631760e-01 0.064 0 0
DAP12 interactions R-HSA-2172127 8.631989e-01 0.064 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.641039e-01 0.063 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.648496e-01 0.063 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.648496e-01 0.063 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.648496e-01 0.063 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.648496e-01 0.063 0 0
vRNA Synthesis R-HSA-192814 8.648496e-01 0.063 0 0
Chylomicron assembly R-HSA-8963888 8.648496e-01 0.063 0 0
Bicarbonate transporters R-HSA-425381 8.648496e-01 0.063 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.648496e-01 0.063 0 0
Transport of RCbl within the body R-HSA-9758890 8.648496e-01 0.063 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.648496e-01 0.063 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.648496e-01 0.063 0 0
LGI-ADAM interactions R-HSA-5682910 8.648496e-01 0.063 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.648496e-01 0.063 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.648496e-01 0.063 0 0
Suppression of apoptosis R-HSA-9635465 8.648496e-01 0.063 0 0
Synthesis of DNA R-HSA-69239 8.661205e-01 0.062 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.664584e-01 0.062 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.664584e-01 0.062 0 0
Gastrulation R-HSA-9758941 8.672883e-01 0.062 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.705638e-01 0.060 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.717608e-01 0.060 0 0
Glycogen synthesis R-HSA-3322077 8.717608e-01 0.060 0 0
Negative regulation of MET activity R-HSA-6807004 8.717608e-01 0.060 0 0
Signaling by NODAL R-HSA-1181150 8.717608e-01 0.060 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.717608e-01 0.060 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.725853e-01 0.059 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.729956e-01 0.059 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.731513e-01 0.059 0 0
Interleukin-1 signaling R-HSA-9020702 8.740682e-01 0.058 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.757272e-01 0.058 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.757272e-01 0.058 0 0
Signaling by MET R-HSA-6806834 8.798074e-01 0.056 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.824874e-01 0.054 0 0
DS-GAG biosynthesis R-HSA-2022923 8.828603e-01 0.054 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.828603e-01 0.054 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.828603e-01 0.054 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.828603e-01 0.054 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.828603e-01 0.054 0 0
ERKs are inactivated R-HSA-202670 8.828603e-01 0.054 0 0
FMO oxidises nucleophiles R-HSA-217271 8.828603e-01 0.054 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.833360e-01 0.054 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.833360e-01 0.054 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.835964e-01 0.054 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.853813e-01 0.053 0 0
G-protein activation R-HSA-202040 8.853813e-01 0.053 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.853813e-01 0.053 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.853813e-01 0.053 0 0
Lagging Strand Synthesis R-HSA-69186 8.853813e-01 0.053 0 0
ERK/MAPK targets R-HSA-198753 8.853813e-01 0.053 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.853813e-01 0.053 0 0
ER-Phagosome pathway R-HSA-1236974 8.914862e-01 0.050 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.976502e-01 0.047 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.976502e-01 0.047 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.976502e-01 0.047 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.977999e-01 0.047 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.977999e-01 0.047 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.977999e-01 0.047 0 0
Signaling by FGFR in disease R-HSA-1226099 8.979833e-01 0.047 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.984718e-01 0.046 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.984718e-01 0.046 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.984718e-01 0.046 0 0
Interleukin-35 Signalling R-HSA-8984722 8.984718e-01 0.046 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.984718e-01 0.046 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.984718e-01 0.046 0 0
MET activates RAS signaling R-HSA-8851805 8.984718e-01 0.046 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.984718e-01 0.046 0 0
Polymerase switching R-HSA-69091 8.984718e-01 0.046 0 0
Leading Strand Synthesis R-HSA-69109 8.984718e-01 0.046 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.984718e-01 0.046 0 0
Signaling by KIT in disease R-HSA-9669938 9.086856e-01 0.042 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.086856e-01 0.042 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.086856e-01 0.042 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.086856e-01 0.042 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.087579e-01 0.042 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.108980e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.108980e-01 0.041 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.120035e-01 0.040 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.120035e-01 0.040 0 0
Chylomicron remodeling R-HSA-8963901 9.120035e-01 0.040 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.120035e-01 0.040 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.120035e-01 0.040 0 0
Processing of SMDT1 R-HSA-8949664 9.120035e-01 0.040 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.120035e-01 0.040 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.144692e-01 0.039 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.168272e-01 0.038 0 0
Interleukin-20 family signaling R-HSA-8854691 9.185984e-01 0.037 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.185984e-01 0.037 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.186424e-01 0.037 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.186424e-01 0.037 0 0
Translation of Structural Proteins R-HSA-9683701 9.186424e-01 0.037 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.190264e-01 0.037 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.225937e-01 0.035 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.228835e-01 0.035 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.228835e-01 0.035 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.237323e-01 0.034 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.237323e-01 0.034 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.237323e-01 0.034 0 0
Hydrolysis of LPC R-HSA-1483115 9.237323e-01 0.034 0 0
Physiological factors R-HSA-5578768 9.237323e-01 0.034 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.237323e-01 0.034 0 0
Ciprofloxacin ADME R-HSA-9793528 9.237323e-01 0.034 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.237323e-01 0.034 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.237323e-01 0.034 0 0
P2Y receptors R-HSA-417957 9.237323e-01 0.034 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.243245e-01 0.034 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.257782e-01 0.033 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.274918e-01 0.033 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.274918e-01 0.033 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.274918e-01 0.033 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.274918e-01 0.033 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.291913e-01 0.032 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.316572e-01 0.031 0 0
Dual Incision in GG-NER R-HSA-5696400 9.316572e-01 0.031 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.338984e-01 0.030 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.338984e-01 0.030 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.338984e-01 0.030 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.338984e-01 0.030 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.338984e-01 0.030 0 0
Translesion synthesis by REV1 R-HSA-110312 9.338984e-01 0.030 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.338984e-01 0.030 0 0
Signaling by Activin R-HSA-1502540 9.338984e-01 0.030 0 0
Transport and metabolism of PAPS R-HSA-174362 9.338984e-01 0.030 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.338984e-01 0.030 0 0
DNA Damage Reversal R-HSA-73942 9.338984e-01 0.030 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.354613e-01 0.029 0 0
Hyaluronan degradation R-HSA-2160916 9.354613e-01 0.029 0 0
Regulation of Apoptosis R-HSA-169911 9.383303e-01 0.028 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.383814e-01 0.028 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.404426e-01 0.027 0 0
MET activates PTK2 signaling R-HSA-8874081 9.425951e-01 0.026 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.425951e-01 0.026 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.425951e-01 0.026 0 0
Abacavir ADME R-HSA-2161522 9.425951e-01 0.026 0 0
Translesion synthesis by POLI R-HSA-5656121 9.427100e-01 0.026 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.427100e-01 0.026 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.427100e-01 0.026 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.427100e-01 0.026 0 0
Differentiation of T cells R-HSA-9945266 9.427100e-01 0.026 0 0
Fructose catabolism R-HSA-70350 9.427100e-01 0.026 0 0
Attachment and Entry R-HSA-9678110 9.427100e-01 0.026 0 0
Signaling by GPCR R-HSA-372790 9.427492e-01 0.026 1 0
Fanconi Anemia Pathway R-HSA-6783310 9.439236e-01 0.025 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.443958e-01 0.025 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.443958e-01 0.025 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.443958e-01 0.025 0 0
Triglyceride catabolism R-HSA-163560 9.443958e-01 0.025 0 0
Cellular response to hypoxia R-HSA-1234174 9.479405e-01 0.023 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.489744e-01 0.023 0 0
Cristae formation R-HSA-8949613 9.489744e-01 0.023 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.489744e-01 0.023 0 0
G alpha (q) signalling events R-HSA-416476 9.497754e-01 0.022 1 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.499031e-01 0.022 0 0
Degradation of DVL R-HSA-4641258 9.499031e-01 0.022 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.500576e-01 0.022 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.502833e-01 0.022 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.503474e-01 0.022 0 0
Translesion synthesis by POLK R-HSA-5655862 9.503474e-01 0.022 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.503474e-01 0.022 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.503474e-01 0.022 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.503474e-01 0.022 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.503474e-01 0.022 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.503474e-01 0.022 0 0
Galactose catabolism R-HSA-70370 9.503474e-01 0.022 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.503474e-01 0.022 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.503474e-01 0.022 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.504092e-01 0.022 0 0
Signaling by Insulin receptor R-HSA-74752 9.539167e-01 0.020 0 0
Synthesis of PA R-HSA-1483166 9.543161e-01 0.020 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.546736e-01 0.020 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.546736e-01 0.020 0 0
Prednisone ADME R-HSA-9757110 9.546736e-01 0.020 0 0
Elastic fibre formation R-HSA-1566948 9.548981e-01 0.020 0 0
Kidney development R-HSA-9830369 9.559710e-01 0.020 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.569670e-01 0.019 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.569670e-01 0.019 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.569670e-01 0.019 0 0
Glycogen storage diseases R-HSA-3229121 9.569670e-01 0.019 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.569670e-01 0.019 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.569670e-01 0.019 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.569670e-01 0.019 0 0
Choline catabolism R-HSA-6798163 9.569670e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9694635 9.581458e-01 0.019 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.594238e-01 0.018 0 0
mRNA Capping R-HSA-72086 9.597604e-01 0.018 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.597604e-01 0.018 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.597604e-01 0.018 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.605655e-01 0.017 0 0
Integrin cell surface interactions R-HSA-216083 9.613950e-01 0.017 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.627044e-01 0.017 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.627044e-01 0.017 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.627044e-01 0.017 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.627044e-01 0.017 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.635204e-01 0.016 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.635204e-01 0.016 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.642970e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.642970e-01 0.016 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.642970e-01 0.016 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.644142e-01 0.016 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.653820e-01 0.015 0 0
Potential therapeutics for SARS R-HSA-9679191 9.663689e-01 0.015 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.676772e-01 0.014 0 0
Methionine salvage pathway R-HSA-1237112 9.676772e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.676772e-01 0.014 0 0
Aquaporin-mediated transport R-HSA-445717 9.682346e-01 0.014 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.683396e-01 0.014 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.683396e-01 0.014 0 0
Nucleotide Excision Repair R-HSA-5696398 9.702358e-01 0.013 0 0
HIV Transcription Initiation R-HSA-167161 9.705724e-01 0.013 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.705724e-01 0.013 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.705724e-01 0.013 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.715929e-01 0.013 0 0
Creatine metabolism R-HSA-71288 9.719871e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.719871e-01 0.012 0 0
Keratan sulfate degradation R-HSA-2022857 9.719871e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.719871e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.719871e-01 0.012 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.735941e-01 0.012 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.735941e-01 0.012 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.751420e-01 0.011 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.751420e-01 0.011 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.757226e-01 0.011 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.757226e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.757226e-01 0.011 0 0
Interferon alpha/beta signaling R-HSA-909733 9.759481e-01 0.011 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.763197e-01 0.010 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.763197e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.787762e-01 0.009 0 0
CS-GAG biosynthesis R-HSA-2022870 9.789602e-01 0.009 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.789602e-01 0.009 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.789602e-01 0.009 0 0
Glutathione synthesis and recycling R-HSA-174403 9.789602e-01 0.009 0 0
Attachment and Entry R-HSA-9694614 9.789602e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.789602e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.789602e-01 0.009 0 0
eNOS activation R-HSA-203615 9.805204e-01 0.009 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.805204e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.805204e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.805204e-01 0.009 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.809885e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.809885e-01 0.008 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.809885e-01 0.008 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.810133e-01 0.008 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.817662e-01 0.008 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.817662e-01 0.008 0 0
LDL clearance R-HSA-8964038 9.817662e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.817662e-01 0.008 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.827677e-01 0.008 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.827677e-01 0.008 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.829795e-01 0.007 0 0
PCP/CE pathway R-HSA-4086400 9.832521e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.832521e-01 0.007 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.841981e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.841981e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.841981e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.841981e-01 0.007 0 0
Carnitine shuttle R-HSA-200425 9.841981e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.841981e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.847622e-01 0.007 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.847700e-01 0.007 0 0
Triglyceride metabolism R-HSA-8979227 9.860490e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.863057e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.863057e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.863790e-01 0.006 0 0
Gluconeogenesis R-HSA-70263 9.863790e-01 0.006 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.865313e-01 0.006 0 0
Degradation of AXIN R-HSA-4641257 9.865313e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.865313e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.865313e-01 0.006 0 0
Downstream TCR signaling R-HSA-202424 9.871926e-01 0.006 0 0
Metabolism of porphyrins R-HSA-189445 9.877308e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.880998e-01 0.005 0 0
Purine salvage R-HSA-74217 9.880998e-01 0.005 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.881324e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.881324e-01 0.005 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.886701e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.886701e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.887882e-01 0.005 0 0
Phospholipid metabolism R-HSA-1483257 9.890664e-01 0.005 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.891854e-01 0.005 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.894460e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.894896e-01 0.005 0 0
RAS processing R-HSA-9648002 9.894896e-01 0.005 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.894896e-01 0.005 0 0
Urea cycle R-HSA-70635 9.897155e-01 0.004 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.897155e-01 0.004 0 0
Mitochondrial protein import R-HSA-1268020 9.897974e-01 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.898468e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.901962e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.907204e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.910875e-01 0.004 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.910875e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.910875e-01 0.004 0 0
Insulin processing R-HSA-264876 9.910875e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.910875e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.910875e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.910875e-01 0.004 0 0
tRNA processing R-HSA-72306 9.914809e-01 0.004 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.917388e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.918100e-01 0.004 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.918100e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.918100e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.918156e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.922617e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.922765e-01 0.003 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.927741e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.927741e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.930913e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.930929e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.930929e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.933069e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.933069e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.933232e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.936268e-01 0.003 0 0
Innate Immune System R-HSA-168249 9.936784e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.938900e-01 0.003 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.942000e-01 0.003 0 0
Mucopolysaccharidoses R-HSA-2206281 9.942000e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.942765e-01 0.002 0 0
G alpha (i) signalling events R-HSA-418594 9.943698e-01 0.002 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.943807e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.946133e-01 0.002 0 0
Neddylation R-HSA-8951664 9.947164e-01 0.002 0 0
Infectious disease R-HSA-5663205 9.947985e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.949739e-01 0.002 0 0
Disease R-HSA-1643685 9.955833e-01 0.002 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.956354e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.956354e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.956354e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.956354e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.956446e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.956446e-01 0.002 0 0
Dual incision in TC-NER R-HSA-6782135 9.956507e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.957100e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.961088e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.961286e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.961286e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.962258e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.963346e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.965114e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.965552e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.965552e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.965552e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.965803e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.966139e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.967295e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.967295e-01 0.001 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.967295e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.967295e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.967295e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.969359e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.969925e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.971660e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.971660e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.971992e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.974918e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.975443e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.975443e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.975544e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.976907e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.978721e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.978745e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.979683e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.981561e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.981561e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.981561e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.982026e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.982371e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.984023e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.984286e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.984931e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.984931e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.985366e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.986156e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.986156e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.986156e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.986437e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.987857e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.989476e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.989606e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.990624e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.990668e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.990668e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.990994e-01 0.000 0 0
Protein localization R-HSA-9609507 9.992067e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.993222e-01 0.000 0 0
Defensins R-HSA-1461973 9.993238e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.993503e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.993648e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.994141e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.994141e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994246e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.994424e-01 0.000 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.994924e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.995182e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.995602e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.995650e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.995898e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996154e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996189e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996231e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996231e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996783e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997139e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997139e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997451e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997456e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997456e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997745e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997853e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998286e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998286e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998497e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998682e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998736e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998790e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998846e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998952e-01 0.000 0 0
Digestion R-HSA-8935690 9.998952e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999318e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999318e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999318e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999394e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999410e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999601e-01 0.000 0 0
Translation R-HSA-72766 9.999613e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999616e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999616e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999707e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999712e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999733e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999761e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999843e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999863e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999893e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999895e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999902e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999909e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999939e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999947e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999957e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999961e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999970e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999971e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999987e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999987e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999987e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999988e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999989e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999992e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999993e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999993e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999996e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999998e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Metabolism of RNA R-HSA-8953854 1.665335e-15 14.778 0 0
Axon guidance R-HSA-422475 1.210143e-14 13.917 0 0
Nervous system development R-HSA-9675108 2.264855e-14 13.645 0 0
Cell Cycle Checkpoints R-HSA-69620 4.458656e-13 12.351 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.044387e-12 11.981 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.644063e-12 11.016 0 0
Nucleosome assembly R-HSA-774815 2.252520e-11 10.647 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.252520e-11 10.647 0 0
G2/M Checkpoints R-HSA-69481 1.977629e-11 10.704 0 0
Signaling by ROBO receptors R-HSA-376176 2.266198e-11 10.645 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.534006e-11 10.452 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.710210e-11 10.431 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.941469e-11 10.404 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.941469e-11 10.404 0 0
Cell-Cell communication R-HSA-1500931 3.952028e-11 10.403 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.254554e-10 9.902 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.450137e-10 9.839 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.005675e-10 9.698 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.256537e-10 9.647 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.697963e-10 9.569 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.022501e-10 9.520 0 0
Mitotic Prophase R-HSA-68875 3.230056e-10 9.491 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.087225e-10 9.389 0 0
Cell junction organization R-HSA-446728 3.975205e-10 9.401 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.305967e-10 9.366 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.041784e-10 9.219 0 0
DNA methylation R-HSA-5334118 7.570359e-10 9.121 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.817588e-10 9.107 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.061967e-09 8.974 0 0
Meiotic recombination R-HSA-912446 1.091287e-09 8.962 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.278441e-09 8.893 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.289601e-09 8.890 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.541648e-09 8.812 0 0
Packaging Of Telomere Ends R-HSA-171306 1.607499e-09 8.794 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.684714e-09 8.773 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.678746e-09 8.775 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.821607e-09 8.740 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.983395e-09 8.703 0 0
Meiosis R-HSA-1500620 2.432080e-09 8.614 0 0
Cellular Senescence R-HSA-2559583 2.712436e-09 8.567 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.542868e-09 8.451 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.839509e-09 8.416 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.785038e-09 8.422 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.887167e-09 8.311 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.395189e-09 8.268 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.460108e-09 8.263 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.640282e-09 8.249 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.640282e-09 8.249 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.499969e-09 8.187 0 0
Peptide chain elongation R-HSA-156902 6.740507e-09 8.171 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.210242e-09 8.142 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.083399e-09 8.092 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.581230e-09 8.066 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.744843e-09 8.058 0 0
Meiotic synapsis R-HSA-1221632 9.094581e-09 8.041 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.021055e-08 7.991 0 0
DNA Double Strand Break Response R-HSA-5693606 1.076551e-08 7.968 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.139547e-08 7.943 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.199545e-08 7.921 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.185611e-08 7.926 0 0
HATs acetylate histones R-HSA-3214847 1.371193e-08 7.863 0 0
Apoptotic execution phase R-HSA-75153 1.540716e-08 7.812 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.624837e-08 7.789 0 0
HDACs deacetylate histones R-HSA-3214815 1.714282e-08 7.766 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.763382e-08 7.754 0 0
G2/M Transition R-HSA-69275 1.806860e-08 7.743 0 0
Kinesins R-HSA-983189 2.003071e-08 7.698 0 0
Mitotic Prometaphase R-HSA-68877 2.148847e-08 7.668 0 0
Defective pyroptosis R-HSA-9710421 2.347085e-08 7.629 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.456926e-08 7.610 0 0
Aggrephagy R-HSA-9646399 2.478484e-08 7.606 0 0
Apoptosis R-HSA-109581 3.386419e-08 7.470 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.557084e-08 7.449 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.700123e-08 7.432 0 0
Signal Transduction R-HSA-162582 3.950029e-08 7.403 1 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.285864e-08 7.368 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.374167e-08 7.359 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.475912e-08 7.349 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.446661e-08 7.264 0 0
mRNA Splicing R-HSA-72172 5.207805e-08 7.283 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.761701e-08 7.170 0 0
Chromatin organization R-HSA-4839726 6.896165e-08 7.161 0 0
Diseases of programmed cell death R-HSA-9645723 7.143520e-08 7.146 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.484252e-08 7.126 0 0
HCMV Early Events R-HSA-9609690 8.002730e-08 7.097 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.002730e-08 7.097 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.577942e-08 7.067 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.577942e-08 7.067 0 0
Chromosome Maintenance R-HSA-73886 8.823168e-08 7.054 0 0
Cellular response to heat stress R-HSA-3371556 8.823168e-08 7.054 0 0
Cell-cell junction organization R-HSA-421270 8.871264e-08 7.052 0 0
Chromatin modifying enzymes R-HSA-3247509 1.101355e-07 6.958 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.113856e-07 6.953 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.151810e-07 6.939 0 0
Mitotic Anaphase R-HSA-68882 1.177780e-07 6.929 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.295977e-07 6.887 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.345536e-07 6.871 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.390738e-07 6.857 0 0
Adherens junctions interactions R-HSA-418990 1.535658e-07 6.814 0 0
Ribosome-associated quality control R-HSA-9948299 1.566575e-07 6.805 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.635124e-07 6.786 0 0
Cleavage of the damaged purine R-HSA-110331 1.658483e-07 6.780 0 0
Depurination R-HSA-73927 2.348942e-07 6.629 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.627267e-07 6.580 0 0
Separation of Sister Chromatids R-HSA-2467813 2.855249e-07 6.544 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.897883e-07 6.538 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.946253e-07 6.531 0 0
Depyrimidination R-HSA-73928 2.946253e-07 6.531 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.257289e-07 6.487 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.207894e-07 6.494 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.426966e-07 6.465 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.444518e-07 6.463 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.765754e-07 6.424 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.939593e-07 6.405 0 0
rRNA processing R-HSA-72312 4.120785e-07 6.385 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.681041e-07 6.330 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.534067e-07 6.344 0 0
Eukaryotic Translation Termination R-HSA-72764 4.844479e-07 6.315 0 0
HSF1 activation R-HSA-3371511 5.065020e-07 6.295 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.953877e-07 6.225 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.703841e-07 6.174 0 0
Selective autophagy R-HSA-9663891 6.703841e-07 6.174 0 0
Programmed Cell Death R-HSA-5357801 7.059000e-07 6.151 0 0
DNA Replication R-HSA-69306 7.812767e-07 6.107 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.087304e-07 6.042 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.536206e-07 6.021 0 0
Membrane Trafficking R-HSA-199991 1.056952e-06 5.976 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.169849e-06 5.932 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.449446e-06 5.839 0 0
Selenocysteine synthesis R-HSA-2408557 1.523601e-06 5.817 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.558163e-06 5.807 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.600601e-06 5.796 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.605907e-06 5.794 0 0
Attenuation phase R-HSA-3371568 1.832394e-06 5.737 0 0
RNA Polymerase I Transcription R-HSA-73864 1.800007e-06 5.745 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.827398e-06 5.738 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.859475e-06 5.731 0 0
Gene Silencing by RNA R-HSA-211000 1.971402e-06 5.705 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.095323e-06 5.679 0 0
Viral mRNA Translation R-HSA-192823 2.186317e-06 5.660 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.339599e-06 5.631 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.366771e-06 5.626 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.466312e-06 5.608 0 0
Homology Directed Repair R-HSA-5693538 2.597943e-06 5.585 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.782677e-06 5.556 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.079121e-06 5.512 0 0
Co-inhibition by PD-1 R-HSA-389948 3.465086e-06 5.460 0 0
ESR-mediated signaling R-HSA-8939211 3.273401e-06 5.485 0 0
Amyloid fiber formation R-HSA-977225 3.343899e-06 5.476 0 0
Reproduction R-HSA-1474165 3.747073e-06 5.426 0 0
HSF1-dependent transactivation R-HSA-3371571 3.823096e-06 5.418 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.191050e-06 5.378 0 0
Post NMDA receptor activation events R-HSA-438064 4.583448e-06 5.339 0 0
Recycling pathway of L1 R-HSA-437239 4.723582e-06 5.326 0 0
L1CAM interactions R-HSA-373760 4.763417e-06 5.322 0 0
Protein folding R-HSA-391251 5.041969e-06 5.297 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.170566e-06 5.286 0 0
Signaling by ALK in cancer R-HSA-9700206 5.170566e-06 5.286 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.792050e-06 5.237 0 0
Influenza Infection R-HSA-168255 5.804682e-06 5.236 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.131365e-06 5.212 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.337795e-06 5.198 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.913650e-06 5.102 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.995815e-06 5.097 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.429989e-06 5.074 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.520849e-06 5.070 0 0
Viral Infection Pathways R-HSA-9824446 8.871200e-06 5.052 0 0
Interleukin-12 signaling R-HSA-9020591 1.038283e-05 4.984 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.157801e-05 4.936 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.241880e-05 4.906 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.270271e-05 4.896 0 0
Telomere Maintenance R-HSA-157579 1.432601e-05 4.844 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.737763e-05 4.760 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.983403e-05 4.703 0 0
HCMV Infection R-HSA-9609646 2.490355e-05 4.604 0 0
Translation initiation complex formation R-HSA-72649 2.558591e-05 4.592 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.775337e-05 4.557 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.075640e-05 4.512 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.270162e-05 4.485 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.290214e-05 4.483 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.862452e-05 4.413 0 0
DNA Repair R-HSA-73894 4.186148e-05 4.378 0 0
Macroautophagy R-HSA-1632852 4.506592e-05 4.346 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.644852e-05 4.333 0 0
Regulation of TP53 Activity R-HSA-5633007 5.078718e-05 4.294 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.121008e-05 4.291 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.995946e-05 4.222 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.995946e-05 4.222 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.478585e-05 4.189 0 0
Autophagy R-HSA-9612973 6.717881e-05 4.173 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.752327e-05 4.171 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.250674e-05 4.140 0 0
Metalloprotease DUBs R-HSA-5689901 7.041267e-05 4.152 0 0
UCH proteinases R-HSA-5689603 7.913920e-05 4.102 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.774412e-05 4.109 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.450602e-05 4.073 0 0
Interleukin-12 family signaling R-HSA-447115 8.642699e-05 4.063 0 0
Signaling by ERBB2 R-HSA-1227986 8.870696e-05 4.052 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.574910e-05 4.019 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.594625e-05 4.018 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.778679e-05 4.010 0 0
Developmental Biology R-HSA-1266738 1.043482e-04 3.982 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.088897e-04 3.963 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.168194e-04 3.932 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.250434e-04 3.903 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.317522e-04 3.880 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.324245e-04 3.878 0 0
Base Excision Repair R-HSA-73884 1.376123e-04 3.861 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.376561e-04 3.861 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.444632e-04 3.840 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.555909e-04 3.808 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.555909e-04 3.808 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.571155e-04 3.804 0 0
Selenoamino acid metabolism R-HSA-2408522 1.631899e-04 3.787 0 0
Centrosome maturation R-HSA-380287 1.747864e-04 3.757 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.848643e-04 3.733 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.839092e-04 3.735 0 0
Cellular response to starvation R-HSA-9711097 1.733537e-04 3.761 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.197208e-04 3.658 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.224598e-04 3.653 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.412017e-04 3.618 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.451173e-04 3.611 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.451173e-04 3.611 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.451173e-04 3.611 0 0
Signaling by WNT R-HSA-195721 2.561394e-04 3.592 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.976660e-04 3.526 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.293974e-04 3.482 0 0
PKR-mediated signaling R-HSA-9833482 3.825503e-04 3.417 0 0
Regulation of CDH1 Function R-HSA-9764561 3.938850e-04 3.405 0 0
mRNA 3'-end processing R-HSA-72187 4.377952e-04 3.359 0 0
Ub-specific processing proteases R-HSA-5689880 4.472974e-04 3.349 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.479987e-04 3.349 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.502755e-04 3.347 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.502755e-04 3.347 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.547089e-04 3.342 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.634974e-04 3.334 0 0
Signaling by VEGF R-HSA-194138 5.007308e-04 3.300 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.920582e-04 3.228 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.066298e-04 3.217 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.066298e-04 3.217 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.553319e-04 3.184 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.622295e-04 3.179 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.892286e-04 3.162 0 0
Gap junction trafficking and regulation R-HSA-157858 6.997708e-04 3.155 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.626777e-04 3.118 0 0
Gene expression (Transcription) R-HSA-74160 7.225663e-04 3.141 0 0
Hedgehog 'off' state R-HSA-5610787 7.140132e-04 3.146 0 0
Activation of BH3-only proteins R-HSA-114452 7.532347e-04 3.123 0 0
Gap junction trafficking R-HSA-190828 7.736114e-04 3.111 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.269612e-04 3.083 0 0
MHC class II antigen presentation R-HSA-2132295 7.400843e-04 3.131 0 0
Gap junction assembly R-HSA-190861 7.301510e-04 3.137 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.442624e-04 3.074 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.027710e-03 2.988 0 0
FLT3 Signaling R-HSA-9607240 1.027710e-03 2.988 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.061882e-03 2.974 0 0
Protein ubiquitination R-HSA-8852135 1.062214e-03 2.974 0 0
Cilium Assembly R-HSA-5617833 1.109988e-03 2.955 0 0
FLT3 signaling in disease R-HSA-9682385 1.115495e-03 2.953 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.134130e-03 2.945 0 0
mTORC1-mediated signalling R-HSA-166208 1.218439e-03 2.914 0 0
MAP2K and MAPK activation R-HSA-5674135 1.243532e-03 2.905 0 0
Deubiquitination R-HSA-5688426 1.282616e-03 2.892 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.336097e-03 2.874 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.435239e-03 2.843 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.470847e-03 2.832 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.472292e-03 2.832 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.482613e-03 2.829 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.482613e-03 2.829 0 0
MTOR signalling R-HSA-165159 1.496042e-03 2.825 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.496042e-03 2.825 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.601512e-03 2.795 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.638524e-03 2.786 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.645229e-03 2.784 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.695264e-03 2.771 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.808934e-03 2.743 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.808934e-03 2.743 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.839028e-03 2.735 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.929685e-03 2.715 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.006266e-03 2.698 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.123781e-03 2.673 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.123781e-03 2.673 0 0
RMTs methylate histone arginines R-HSA-3214858 2.130173e-03 2.672 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.359394e-03 2.627 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.576240e-03 2.589 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.576240e-03 2.589 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.467276e-03 2.608 0 0
FOXO-mediated transcription R-HSA-9614085 2.852145e-03 2.545 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.597708e-03 2.585 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.811820e-03 2.551 0 0
Signaling by PTK6 R-HSA-8848021 2.573876e-03 2.589 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.573876e-03 2.589 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.864442e-03 2.543 0 0
Signaling by RAS mutants R-HSA-6802949 2.971824e-03 2.527 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.971824e-03 2.527 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.971824e-03 2.527 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.971824e-03 2.527 0 0
Vesicle-mediated transport R-HSA-5653656 3.048147e-03 2.516 0 0
Host Interactions of HIV factors R-HSA-162909 3.218038e-03 2.492 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.223334e-03 2.492 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.281391e-03 2.484 0 0
S Phase R-HSA-69242 3.327338e-03 2.478 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.346630e-03 2.475 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.398379e-03 2.469 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.398379e-03 2.469 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.398379e-03 2.469 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.398379e-03 2.469 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.398379e-03 2.469 0 0
Translation R-HSA-72766 3.507331e-03 2.455 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.880079e-03 2.411 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.880079e-03 2.411 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.880079e-03 2.411 0 0
HIV Life Cycle R-HSA-162587 3.922320e-03 2.406 0 0
HCMV Late Events R-HSA-9610379 3.922320e-03 2.406 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.945423e-03 2.404 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.010430e-03 2.397 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.504462e-03 2.346 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.504462e-03 2.346 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.504462e-03 2.346 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.504462e-03 2.346 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.728671e-03 2.325 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.728671e-03 2.325 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.769946e-03 2.321 0 0
RNA Polymerase II Transcription R-HSA-73857 5.071526e-03 2.295 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.199179e-03 2.284 0 0
Signaling by EGFR R-HSA-177929 5.365468e-03 2.270 0 0
Signaling by NOTCH R-HSA-157118 5.585726e-03 2.253 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.823068e-03 2.235 0 0
Semaphorin interactions R-HSA-373755 5.917201e-03 2.228 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.199674e-03 2.208 0 0
HIV Infection R-HSA-162906 6.305356e-03 2.200 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.323051e-03 2.199 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.374348e-03 2.196 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.374348e-03 2.196 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.397084e-03 2.194 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.397084e-03 2.194 0 0
Deadenylation of mRNA R-HSA-429947 6.406444e-03 2.193 0 0
Nephrin family interactions R-HSA-373753 6.856688e-03 2.164 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.187338e-03 2.143 0 0
G1/S Transition R-HSA-69206 7.188262e-03 2.143 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.345311e-03 2.134 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.405170e-03 2.130 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.637990e-03 2.117 0 0
RET signaling R-HSA-8853659 8.649549e-03 2.063 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.534804e-03 2.069 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.758822e-03 2.058 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.758822e-03 2.058 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.492921e-03 2.023 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.068361e-03 2.093 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.033998e-03 2.044 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.398269e-03 2.076 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.703068e-03 2.013 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.565157e-03 2.019 0 0
Intraflagellar transport R-HSA-5620924 9.795530e-03 2.009 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.936119e-03 2.003 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.012614e-02 1.995 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.054385e-02 1.977 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.081262e-02 1.966 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.081262e-02 1.966 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.081262e-02 1.966 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.084695e-02 1.965 1 0
Adaptive Immune System R-HSA-1280218 1.107480e-02 1.956 0 0
DNA Damage Bypass R-HSA-73893 1.119709e-02 1.951 0 0
Signaling by Hippo R-HSA-2028269 1.138179e-02 1.944 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.140341e-02 1.943 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.140341e-02 1.943 0 0
Signaling by FGFR4 R-HSA-5654743 1.157200e-02 1.937 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.197130e-02 1.922 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.202216e-02 1.920 0 0
Maturation of protein E R-HSA-9694493 1.202216e-02 1.920 0 0
Maturation of protein E R-HSA-9683683 1.202216e-02 1.920 0 0
TNF signaling R-HSA-75893 1.213249e-02 1.916 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.213249e-02 1.916 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.327551e-02 1.877 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.343733e-02 1.872 0 0
Signaling by Hedgehog R-HSA-5358351 1.344248e-02 1.872 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.365232e-02 1.865 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.365232e-02 1.865 0 0
Striated Muscle Contraction R-HSA-390522 1.379609e-02 1.860 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.436969e-02 1.843 0 0
Josephin domain DUBs R-HSA-5689877 1.478681e-02 1.830 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.478681e-02 1.830 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.505089e-02 1.822 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.505089e-02 1.822 0 0
Signaling by FGFR3 R-HSA-5654741 1.516405e-02 1.819 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.520283e-02 1.818 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.557741e-02 1.808 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.573005e-02 1.803 0 0
Late endosomal microautophagy R-HSA-9615710 1.606718e-02 1.794 0 0
Nuclear import of Rev protein R-HSA-180746 1.607340e-02 1.794 0 0
Orc1 removal from chromatin R-HSA-68949 1.634589e-02 1.787 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.049650e-02 1.688 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.049650e-02 1.688 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.049650e-02 1.688 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.049650e-02 1.688 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.049650e-02 1.688 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.049650e-02 1.688 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.792511e-02 1.747 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.792511e-02 1.747 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.904367e-02 1.720 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.904367e-02 1.720 0 0
Regulation of signaling by CBL R-HSA-912631 1.744768e-02 1.758 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.744768e-02 1.758 0 0
HDMs demethylate histones R-HSA-3214842 2.202314e-02 1.657 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.886299e-02 1.724 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.886299e-02 1.724 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.199549e-02 1.658 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.199549e-02 1.658 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.861813e-02 1.730 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.861813e-02 1.730 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.724936e-02 1.763 0 0
EGFR downregulation R-HSA-182971 2.199549e-02 1.658 0 0
Translesion Synthesis by POLH R-HSA-110320 1.744768e-02 1.758 0 0
Rap1 signalling R-HSA-392517 1.744768e-02 1.758 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.803622e-02 1.744 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.724936e-02 1.763 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.803622e-02 1.744 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.841016e-02 1.735 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.724936e-02 1.763 0 0
Signaling by FGFR2 R-HSA-5654738 1.863801e-02 1.730 0 0
Signalling to ERKs R-HSA-187687 1.861813e-02 1.730 0 0
Negative regulation of MET activity R-HSA-6807004 2.120687e-02 1.674 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.711046e-02 1.767 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.904367e-02 1.720 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.921939e-02 1.716 0 0
Signaling by Interleukins R-HSA-449147 2.070744e-02 1.684 0 0
Smooth Muscle Contraction R-HSA-445355 1.841016e-02 1.735 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.963617e-02 1.707 0 0
IRE1alpha activates chaperones R-HSA-381070 1.720799e-02 1.764 0 0
Glycolysis R-HSA-70171 2.214426e-02 1.655 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.232690e-02 1.651 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.370376e-02 1.625 0 0
tRNA processing in the nucleus R-HSA-6784531 2.384921e-02 1.623 0 0
Neutrophil degranulation R-HSA-6798695 2.391305e-02 1.621 0 0
Muscle contraction R-HSA-397014 2.446486e-02 1.611 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.457562e-02 1.609 0 0
Degradation of CDH1 R-HSA-9766229 2.480163e-02 1.606 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.482166e-02 1.605 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.482166e-02 1.605 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.482166e-02 1.605 0 0
Regulation of PTEN localization R-HSA-8948747 2.482166e-02 1.605 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.542492e-02 1.595 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.549405e-02 1.594 0 0
Signaling by FGFR1 R-HSA-5654736 2.578533e-02 1.589 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.630374e-02 1.580 0 0
Hemostasis R-HSA-109582 2.733291e-02 1.563 1 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.801981e-02 1.553 0 0
Disorders of Developmental Biology R-HSA-9675151 2.907162e-02 1.537 0 0
Integrin signaling R-HSA-354192 2.934756e-02 1.532 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.934756e-02 1.532 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.981571e-02 1.526 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.023561e-02 1.519 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.033846e-02 1.518 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.033846e-02 1.518 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.095702e-02 1.509 0 0
SARS-CoV Infections R-HSA-9679506 3.136915e-02 1.503 0 0
Interferon Signaling R-HSA-913531 3.144838e-02 1.502 0 0
Stabilization of p53 R-HSA-69541 3.179401e-02 1.498 0 0
Generic Transcription Pathway R-HSA-212436 3.185927e-02 1.497 0 0
Regulation of IFNG signaling R-HSA-877312 3.220478e-02 1.492 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.220478e-02 1.492 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.220478e-02 1.492 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.220478e-02 1.492 0 0
Signaling by LTK R-HSA-9842663 3.220478e-02 1.492 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.220478e-02 1.492 0 0
Type I hemidesmosome assembly R-HSA-446107 3.343849e-02 1.476 0 0
Adrenoceptors R-HSA-390696 3.343849e-02 1.476 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.343849e-02 1.476 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.343849e-02 1.476 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.343849e-02 1.476 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.360276e-02 1.474 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.360276e-02 1.474 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.504064e-02 1.455 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.504064e-02 1.455 0 0
Signaling by MET R-HSA-6806834 3.507742e-02 1.455 0 0
MAPK family signaling cascades R-HSA-5683057 3.605102e-02 1.443 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.826555e-02 1.417 0 0
Dual Incision in GG-NER R-HSA-5696400 3.826555e-02 1.417 0 0
Mitophagy R-HSA-5205647 3.826555e-02 1.417 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.826555e-02 1.417 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.826555e-02 1.417 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.826555e-02 1.417 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.830515e-02 1.417 0 0
Signaling by NOTCH4 R-HSA-9013694 3.858039e-02 1.414 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.001426e-02 1.398 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.001426e-02 1.398 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.033687e-02 1.394 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.033687e-02 1.394 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.033687e-02 1.394 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.168226e-02 1.380 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.202457e-02 1.376 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.203592e-02 1.376 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.206145e-02 1.376 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.206145e-02 1.376 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.236095e-02 1.373 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.296542e-02 1.367 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.335009e-02 1.363 0 0
Unwinding of DNA R-HSA-176974 4.359237e-02 1.361 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.802679e-02 1.236 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.802679e-02 1.236 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.528859e-02 1.257 0 0
Binding and entry of HIV virion R-HSA-173107 5.528859e-02 1.257 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.528859e-02 1.257 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.880910e-02 1.231 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.880910e-02 1.231 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.973200e-02 1.303 0 0
Formation of definitive endoderm R-HSA-9823730 5.820700e-02 1.235 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.820700e-02 1.235 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.820700e-02 1.235 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.820700e-02 1.235 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.820700e-02 1.235 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.749309e-02 1.171 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.246407e-02 1.280 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.671231e-02 1.176 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.671231e-02 1.176 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.134848e-02 1.289 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.654080e-02 1.248 0 0
IGF1R signaling cascade R-HSA-2428924 5.570635e-02 1.254 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.829773e-02 1.234 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.857530e-02 1.314 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.749309e-02 1.171 0 0
Nucleotide Excision Repair R-HSA-5696398 5.896472e-02 1.229 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.671231e-02 1.176 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.063297e-02 1.217 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.880910e-02 1.231 0 0
TCR signaling R-HSA-202403 4.991088e-02 1.302 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.614024e-02 1.336 0 0
Neurodegenerative Diseases R-HSA-8863678 4.845446e-02 1.315 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.845446e-02 1.315 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.887844e-02 1.311 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.887844e-02 1.311 0 0
Translesion synthesis by REV1 R-HSA-110312 5.880910e-02 1.231 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.368728e-02 1.196 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.931887e-02 1.227 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.646469e-02 1.248 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.516581e-02 1.345 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.671231e-02 1.176 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.668307e-02 1.331 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.629451e-02 1.250 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.845446e-02 1.315 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.886880e-02 1.311 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.710748e-02 1.327 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.508431e-02 1.346 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.368728e-02 1.196 0 0
Degradation of DVL R-HSA-4641258 5.483225e-02 1.261 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.712070e-02 1.173 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.802679e-02 1.236 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.749309e-02 1.171 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.671231e-02 1.176 0 0
GPVI-mediated activation cascade R-HSA-114604 4.886880e-02 1.311 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.557485e-02 1.255 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.802679e-02 1.236 0 0
Signaling by FGFR R-HSA-190236 5.709664e-02 1.243 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.445903e-02 1.191 0 0
Synthesis of DNA R-HSA-69239 6.702827e-02 1.174 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.160146e-02 1.287 0 0
Interleukin-7 signaling R-HSA-1266695 5.574750e-02 1.254 0 0
Basigin interactions R-HSA-210991 6.749309e-02 1.171 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.390932e-02 1.268 0 0
Signaling by NTRKs R-HSA-166520 4.519444e-02 1.345 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.880910e-02 1.231 0 0
Cellular response to chemical stress R-HSA-9711123 5.377955e-02 1.269 0 0
Signaling by Leptin R-HSA-2586552 5.528859e-02 1.257 0 0
p75NTR signals via NF-kB R-HSA-193639 5.880910e-02 1.231 0 0
Pexophagy R-HSA-9664873 5.528859e-02 1.257 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.766476e-02 1.170 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.804420e-02 1.167 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.804420e-02 1.167 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.845564e-02 1.165 0 0
DAG and IP3 signaling R-HSA-1489509 6.845564e-02 1.165 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.980517e-02 1.156 0 0
Translesion synthesis by POLI R-HSA-5656121 6.980517e-02 1.156 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.980517e-02 1.156 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.980517e-02 1.156 0 0
Negative regulation of FLT3 R-HSA-9706369 6.980517e-02 1.156 0 0
Regulation of BACH1 activity R-HSA-9708530 6.980517e-02 1.156 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.121131e-02 1.147 0 0
Regulation of TP53 Expression R-HSA-6804754 7.121131e-02 1.147 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.121131e-02 1.147 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 7.121131e-02 1.147 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.121131e-02 1.147 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.121131e-02 1.147 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.121131e-02 1.147 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.133988e-02 1.147 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.227897e-02 1.141 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.227897e-02 1.141 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.436756e-02 1.129 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.526081e-02 1.123 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.546700e-02 1.122 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.627137e-02 1.118 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.758990e-02 1.110 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.758990e-02 1.110 0 0
Assembly Of The HIV Virion R-HSA-175474 7.758990e-02 1.110 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.048109e-02 1.094 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.048109e-02 1.094 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.185345e-02 1.087 0 0
Translesion synthesis by POLK R-HSA-5655862 8.185345e-02 1.087 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.313092e-02 1.080 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.313092e-02 1.080 0 0
Activation of RAC1 R-HSA-428540 8.319425e-02 1.080 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.319425e-02 1.080 0 0
NF-kB is activated and signals survival R-HSA-209560 8.319425e-02 1.080 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.327501e-02 1.079 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.327501e-02 1.079 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.327501e-02 1.079 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.327501e-02 1.079 0 0
Glucose metabolism R-HSA-70326 8.643558e-02 1.063 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.809673e-02 1.055 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.849023e-02 1.053 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.915556e-02 1.050 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.009401e-02 1.045 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.141705e-02 1.039 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.155008e-02 1.038 0 0
Infectious disease R-HSA-5663205 9.202774e-02 1.036 0 0
Regulation of Apoptosis R-HSA-169911 9.215662e-02 1.035 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.261864e-02 1.033 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.450263e-02 1.025 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.492944e-02 1.023 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.492944e-02 1.023 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.550494e-02 1.020 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.625419e-02 1.017 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.625419e-02 1.017 0 0
SOS-mediated signalling R-HSA-112412 9.712170e-02 1.013 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.712170e-02 1.013 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.712170e-02 1.013 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.750919e-02 1.011 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.928951e-02 1.003 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.928951e-02 1.003 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.928951e-02 1.003 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.928951e-02 1.003 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.928951e-02 1.003 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.001804e-01 0.999 0 0
Activation of the pre-replicative complex R-HSA-68962 1.019522e-01 0.992 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.030929e-01 0.987 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.030929e-01 0.987 0 0
MET interacts with TNS proteins R-HSA-8875513 1.038056e-01 0.984 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.038056e-01 0.984 0 0
MET activates PTPN11 R-HSA-8865999 1.038056e-01 0.984 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.059205e-01 0.975 0 0
Cellular response to hypoxia R-HSA-1234174 1.073180e-01 0.969 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.075235e-01 0.968 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.089984e-01 0.963 0 0
Ephrin signaling R-HSA-3928664 1.089984e-01 0.963 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.089984e-01 0.963 0 0
Platelet sensitization by LDL R-HSA-432142 1.089984e-01 0.963 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.094917e-01 0.961 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.094917e-01 0.961 0 0
Dual incision in TC-NER R-HSA-6782135 1.114052e-01 0.953 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.118034e-01 0.952 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.118201e-01 0.951 0 0
Degradation of AXIN R-HSA-4641257 1.118201e-01 0.951 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.131171e-01 0.946 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.153948e-01 0.938 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.167059e-01 0.933 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.167059e-01 0.933 0 0
Frs2-mediated activation R-HSA-170968 1.167059e-01 0.933 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.167059e-01 0.933 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.180372e-01 0.928 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.197593e-01 0.922 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.197593e-01 0.922 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.197593e-01 0.922 0 0
Metabolism of non-coding RNA R-HSA-194441 1.198921e-01 0.921 0 0
snRNP Assembly R-HSA-191859 1.198921e-01 0.921 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.955631e-01 0.709 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.955631e-01 0.709 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.955631e-01 0.709 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.955631e-01 0.709 0 0
Defective GALM causes GALAC4 R-HSA-9931929 1.955631e-01 0.709 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.955631e-01 0.709 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.395525e-01 0.855 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.774565e-01 0.751 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.774565e-01 0.751 0 0
Activation of AKT2 R-HSA-165158 1.774565e-01 0.751 0 0
IRS activation R-HSA-74713 1.774565e-01 0.751 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.441182e-01 0.841 0 0
Lipophagy R-HSA-9613354 1.441182e-01 0.841 0 0
WNT mediated activation of DVL R-HSA-201688 1.441182e-01 0.841 0 0
ALK mutants bind TKIs R-HSA-9700645 1.441182e-01 0.841 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.166935e-01 0.664 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.166935e-01 0.664 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.166935e-01 0.664 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.166935e-01 0.664 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.699341e-01 0.770 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.699341e-01 0.770 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.699341e-01 0.770 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.969451e-01 0.706 0 0
Erythropoietin activates RAS R-HSA-9027284 1.550977e-01 0.809 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.240164e-01 0.907 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.399318e-01 0.854 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.399318e-01 0.854 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.399318e-01 0.854 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.758477e-01 0.755 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.758477e-01 0.755 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.248970e-01 0.648 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.248970e-01 0.648 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.248970e-01 0.648 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.258455e-01 0.900 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.974737e-01 0.704 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.974737e-01 0.704 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.543620e-01 0.811 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.198521e-01 0.658 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.198521e-01 0.658 0 0
FGFR2 alternative splicing R-HSA-6803529 1.924492e-01 0.716 0 0
HIV elongation arrest and recovery R-HSA-167287 1.695990e-01 0.771 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.695990e-01 0.771 0 0
Signaling by Erythropoietin R-HSA-9006335 1.854327e-01 0.732 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.854327e-01 0.732 0 0
RAF activation R-HSA-5673000 1.637099e-01 0.786 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.240460e-01 0.650 0 0
EPH-Ephrin signaling R-HSA-2682334 2.272509e-01 0.643 0 0
Signalling to RAS R-HSA-167044 1.566858e-01 0.805 0 0
Intra-Golgi traffic R-HSA-6811438 1.698700e-01 0.770 0 0
Generation of second messenger molecules R-HSA-202433 1.452000e-01 0.838 0 0
Signal attenuation R-HSA-74749 1.699341e-01 0.770 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.924492e-01 0.716 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.974737e-01 0.704 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.360450e-01 0.627 0 0
Regulation of CDH11 function R-HSA-9762292 1.699341e-01 0.770 0 0
p38MAPK events R-HSA-171007 1.550977e-01 0.809 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 1.924492e-01 0.716 0 0
GPER1 signaling R-HSA-9634597 1.621353e-01 0.790 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.496587e-01 0.825 0 0
Transcription of the HIV genome R-HSA-167172 2.112247e-01 0.675 0 0
Dopamine receptors R-HSA-390651 1.395525e-01 0.855 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.395525e-01 0.855 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.974737e-01 0.704 0 0
Nuclear RNA decay R-HSA-9930044 1.372702e-01 0.862 0 0
ER-Phagosome pathway R-HSA-1236974 1.878291e-01 0.726 0 0
The NLRP3 inflammasome R-HSA-844456 1.240164e-01 0.907 0 0
Integration of provirus R-HSA-162592 2.248970e-01 0.648 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.071750e-01 0.684 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.052153e-01 0.688 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.395525e-01 0.855 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.441182e-01 0.841 0 0
Tight junction interactions R-HSA-420029 1.258455e-01 0.900 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.113183e-01 0.675 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.018173e-01 0.695 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.242623e-01 0.649 0 0
Ion homeostasis R-HSA-5578775 1.653822e-01 0.782 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.039973e-01 0.690 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.974737e-01 0.704 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.240164e-01 0.907 0 0
Signal transduction by L1 R-HSA-445144 1.399318e-01 0.854 0 0
Interleukin-2 signaling R-HSA-9020558 1.969451e-01 0.706 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.307477e-01 0.637 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.419407e-01 0.848 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.777215e-01 0.750 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.224412e-01 0.912 0 0
DNA strand elongation R-HSA-69190 2.360450e-01 0.627 0 0
Ca-dependent events R-HSA-111996 1.828719e-01 0.738 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.258455e-01 0.900 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.828719e-01 0.738 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.774565e-01 0.751 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.777215e-01 0.750 0 0
Calmodulin induced events R-HSA-111933 1.922209e-01 0.716 0 0
PLC beta mediated events R-HSA-112043 2.240460e-01 0.650 0 0
Protein methylation R-HSA-8876725 1.550977e-01 0.809 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.637099e-01 0.786 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.224412e-01 0.912 0 0
CaM pathway R-HSA-111997 1.922209e-01 0.716 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.699341e-01 0.770 0 0
Prolonged ERK activation events R-HSA-169893 1.758477e-01 0.755 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.955631e-01 0.709 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.774565e-01 0.751 0 0
DCC mediated attractive signaling R-HSA-418885 1.550977e-01 0.809 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.198521e-01 0.658 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.637099e-01 0.786 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.292518e-01 0.889 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.292518e-01 0.889 0 0
PCP/CE pathway R-HSA-4086400 2.324517e-01 0.634 0 0
Death Receptor Signaling R-HSA-73887 1.867909e-01 0.729 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.677522e-01 0.775 0 0
PTEN Regulation R-HSA-6807070 1.359211e-01 0.867 0 0
RAS processing R-HSA-9648002 1.335728e-01 0.874 0 0
Amine ligand-binding receptors R-HSA-375280 2.100936e-01 0.678 0 0
MAP kinase activation R-HSA-450294 1.379176e-01 0.860 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.924492e-01 0.716 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.258455e-01 0.900 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.674832e-01 0.776 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.397644e-01 0.855 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.307477e-01 0.637 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.387667e-01 0.622 0 0
Platelet degranulation R-HSA-114608 1.503483e-01 0.823 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.974737e-01 0.704 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.404221e-01 0.853 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.407145e-01 0.618 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.353449e-01 0.869 0 0
PECAM1 interactions R-HSA-210990 1.969451e-01 0.706 0 0
Long-term potentiation R-HSA-9620244 1.258455e-01 0.900 0 0
Interleukin-17 signaling R-HSA-448424 2.347298e-01 0.629 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.299339e-01 0.638 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.366614e-01 0.626 0 0
Pyruvate metabolism R-HSA-70268 1.694460e-01 0.771 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.448241e-01 0.839 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.379176e-01 0.860 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.507581e-01 0.822 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.448241e-01 0.839 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.448241e-01 0.839 0 0
Interleukin-1 signaling R-HSA-9020702 1.685807e-01 0.773 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.258455e-01 0.900 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.258455e-01 0.900 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.757746e-01 0.755 0 0
Regulated Necrosis R-HSA-5218859 1.317825e-01 0.880 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.187047e-01 0.660 0 0
Transmission across Chemical Synapses R-HSA-112315 2.401415e-01 0.620 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.958887e-01 0.708 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.742145e-01 0.759 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.667294e-01 0.778 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.097381e-01 0.678 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.452000e-01 0.838 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.292518e-01 0.889 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.442610e-01 0.841 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.347298e-01 0.629 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.985764e-01 0.702 0 0
Netrin-1 signaling R-HSA-373752 2.100936e-01 0.678 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.543620e-01 0.811 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.242623e-01 0.649 0 0
Syndecan interactions R-HSA-3000170 2.113183e-01 0.675 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.985764e-01 0.702 0 0
NrCAM interactions R-HSA-447038 1.774565e-01 0.751 0 0
Co-inhibition by BTLA R-HSA-9927353 1.774565e-01 0.751 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.166935e-01 0.664 0 0
Growth hormone receptor signaling R-HSA-982772 2.113183e-01 0.675 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.383075e-01 0.623 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.442519e-01 0.841 0 0
Diseases of DNA repair R-HSA-9675135 2.387667e-01 0.622 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.166935e-01 0.664 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.974737e-01 0.704 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.924492e-01 0.716 0 0
Translation of Structural Proteins R-HSA-9683701 1.698700e-01 0.770 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.969451e-01 0.706 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.359211e-01 0.867 0 0
Glycogen storage diseases R-HSA-3229121 2.198521e-01 0.658 0 0
GAB1 signalosome R-HSA-180292 2.428589e-01 0.615 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.428589e-01 0.615 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.444278e-01 0.612 0 0
Hedgehog 'on' state R-HSA-5632684 2.468418e-01 0.608 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.506621e-01 0.601 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.535479e-01 0.596 0 0
Pervasive developmental disorders R-HSA-9005895 2.535479e-01 0.596 0 0
Disorders of Nervous System Development R-HSA-9697154 2.535479e-01 0.596 0 0
Interleukin-15 signaling R-HSA-8983432 2.535479e-01 0.596 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.535479e-01 0.596 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.535479e-01 0.596 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.537871e-01 0.596 0 0
G-protein beta:gamma signalling R-HSA-397795 2.537871e-01 0.596 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.537871e-01 0.596 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.537871e-01 0.596 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.537871e-01 0.596 0 0
STAT5 Activation R-HSA-9645135 2.565863e-01 0.591 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.565863e-01 0.591 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 2.565863e-01 0.591 0 0
CREB phosphorylation R-HSA-199920 2.565863e-01 0.591 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.565863e-01 0.591 0 0
Insulin receptor signalling cascade R-HSA-74751 2.626349e-01 0.581 0 0
Circadian clock R-HSA-9909396 2.654609e-01 0.576 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.658522e-01 0.575 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.658522e-01 0.575 0 0
NGF-stimulated transcription R-HSA-9031628 2.686682e-01 0.571 0 0
Co-stimulation by CD28 R-HSA-389356 2.686682e-01 0.571 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.708260e-01 0.567 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.709859e-01 0.567 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.709859e-01 0.567 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.717074e-01 0.566 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.718789e-01 0.566 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.718789e-01 0.566 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.785046e-01 0.555 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.785046e-01 0.555 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.785046e-01 0.555 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.785046e-01 0.555 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.785046e-01 0.555 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.785046e-01 0.555 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.785046e-01 0.555 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.785046e-01 0.555 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.785046e-01 0.555 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.785046e-01 0.555 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.785046e-01 0.555 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.785046e-01 0.555 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.785046e-01 0.555 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.785046e-01 0.555 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.785046e-01 0.555 0 0
IRS-mediated signalling R-HSA-112399 2.800921e-01 0.553 0 0
Interleukin-6 signaling R-HSA-1059683 2.826711e-01 0.549 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.826711e-01 0.549 0 0
Maturation of nucleoprotein R-HSA-9683610 2.826711e-01 0.549 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.854296e-01 0.545 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.854833e-01 0.544 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.854833e-01 0.544 0 0
Downstream TCR signaling R-HSA-202424 2.861357e-01 0.543 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.875097e-01 0.541 0 0
Signaling by NOTCH2 R-HSA-1980145 2.902683e-01 0.537 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.902683e-01 0.537 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.902683e-01 0.537 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.902716e-01 0.537 0 0
Protein hydroxylation R-HSA-9629569 2.902716e-01 0.537 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.902716e-01 0.537 0 0
Glycogen synthesis R-HSA-3322077 2.902716e-01 0.537 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.916439e-01 0.535 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.965831e-01 0.528 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.965831e-01 0.528 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.965831e-01 0.528 0 0
Disinhibition of SNARE formation R-HSA-114516 2.965831e-01 0.528 0 0
CHL1 interactions R-HSA-447041 2.965831e-01 0.528 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.965831e-01 0.528 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.965831e-01 0.528 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.978637e-01 0.526 0 0
PI3K Cascade R-HSA-109704 2.995626e-01 0.524 0 0
G-protein mediated events R-HSA-112040 3.031639e-01 0.518 0 0
Oncogene Induced Senescence R-HSA-2559585 3.089031e-01 0.510 0 0
Regulation of beta-cell development R-HSA-186712 3.091671e-01 0.510 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.120571e-01 0.506 0 0
Prolactin receptor signaling R-HSA-1170546 3.120571e-01 0.506 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.120571e-01 0.506 0 0
Regulation of KIT signaling R-HSA-1433559 3.120571e-01 0.506 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.120571e-01 0.506 0 0
HDL assembly R-HSA-8963896 3.120571e-01 0.506 0 0
Inflammasomes R-HSA-622312 3.125621e-01 0.505 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.144432e-01 0.502 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.144432e-01 0.502 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.144432e-01 0.502 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.160145e-01 0.500 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.160145e-01 0.500 0 0
Signaling by SCF-KIT R-HSA-1433557 3.215314e-01 0.493 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.215314e-01 0.493 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.312082e-01 0.480 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.336682e-01 0.477 0 0
DARPP-32 events R-HSA-180024 3.336682e-01 0.477 0 0
Formation of annular gap junctions R-HSA-196025 3.362386e-01 0.473 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.362386e-01 0.473 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.387768e-01 0.470 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.387768e-01 0.470 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.387768e-01 0.470 0 0
Proteasome assembly R-HSA-9907900 3.387921e-01 0.470 0 0
Cyclin D associated events in G1 R-HSA-69231 3.387921e-01 0.470 0 0
G1 Phase R-HSA-69236 3.387921e-01 0.470 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.388724e-01 0.470 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.415146e-01 0.467 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.415146e-01 0.467 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.415146e-01 0.467 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.472368e-01 0.459 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.472368e-01 0.459 0 0
PI Metabolism R-HSA-1483255 3.496144e-01 0.456 0 0
Potassium transport channels R-HSA-1296067 3.528987e-01 0.452 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.528987e-01 0.452 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.528987e-01 0.452 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.528987e-01 0.452 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.528987e-01 0.452 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.528987e-01 0.452 0 0
C6 deamination of adenosine R-HSA-75102 3.528987e-01 0.452 0 0
DAP12 signaling R-HSA-2424491 3.548922e-01 0.450 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.548922e-01 0.450 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.561684e-01 0.448 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.614360e-01 0.442 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.631689e-01 0.440 0 0
Neuronal System R-HSA-112316 3.671934e-01 0.435 0 0
Phosphorylation of the APC/C R-HSA-176412 3.708713e-01 0.431 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.708713e-01 0.431 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.708713e-01 0.431 0 0
Opioid Signalling R-HSA-111885 3.732750e-01 0.428 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.735551e-01 0.428 0 0
Potential therapeutics for SARS R-HSA-9679191 3.735953e-01 0.428 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.736230e-01 0.428 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.751982e-01 0.426 0 0
Gap junction degradation R-HSA-190873 3.751982e-01 0.426 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.751982e-01 0.426 0 0
ARMS-mediated activation R-HSA-170984 3.751982e-01 0.426 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.751982e-01 0.426 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.751982e-01 0.426 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.751982e-01 0.426 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.751982e-01 0.426 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.751982e-01 0.426 0 0
Trafficking of AMPA receptors R-HSA-399719 3.761671e-01 0.425 0 0
Budding and maturation of HIV virion R-HSA-162588 3.761671e-01 0.425 0 0
Downstream signal transduction R-HSA-186763 3.761671e-01 0.425 0 0
G alpha (z) signalling events R-HSA-418597 3.795560e-01 0.421 1 1
Signaling by ALK R-HSA-201556 3.848795e-01 0.415 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.875227e-01 0.412 0 0
Formation of the ureteric bud R-HSA-9830674 3.875227e-01 0.412 0 0
Interleukin-1 family signaling R-HSA-446652 3.933203e-01 0.405 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.974289e-01 0.401 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.999736e-01 0.398 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.999736e-01 0.398 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.999736e-01 0.398 0 0
Signaling by ERBB4 R-HSA-1236394 4.022323e-01 0.396 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.039897e-01 0.394 0 0
Glycogen metabolism R-HSA-8982491 4.039897e-01 0.394 0 0
Immune System R-HSA-168256 4.070739e-01 0.390 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.117483e-01 0.385 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.131841e-01 0.384 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.131841e-01 0.384 0 0
PI3K/AKT activation R-HSA-198203 4.131841e-01 0.384 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.131841e-01 0.384 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.131841e-01 0.384 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.131841e-01 0.384 0 0
2-LTR circle formation R-HSA-164843 4.131841e-01 0.384 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.131841e-01 0.384 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.186170e-01 0.378 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.186170e-01 0.378 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.186170e-01 0.378 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.196260e-01 0.377 0 0
Axonal growth stimulation R-HSA-209563 4.196260e-01 0.377 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.196260e-01 0.377 0 0
Invadopodia formation R-HSA-8941237 4.196260e-01 0.377 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.196260e-01 0.377 0 0
Histamine receptors R-HSA-390650 4.196260e-01 0.377 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.203570e-01 0.376 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.260964e-01 0.370 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.286863e-01 0.368 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.286863e-01 0.368 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.286863e-01 0.368 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.318078e-01 0.365 0 0
Signaling by Insulin receptor R-HSA-74752 4.324147e-01 0.364 0 0
Developmental Cell Lineages R-HSA-9734767 4.373105e-01 0.359 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.396747e-01 0.357 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.396747e-01 0.357 0 0
Translation of Structural Proteins R-HSA-9694635 4.453120e-01 0.351 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.499830e-01 0.347 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.499830e-01 0.347 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.499830e-01 0.347 0 0
LGI-ADAM interactions R-HSA-5682910 4.499830e-01 0.347 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.499830e-01 0.347 0 0
Signaling by APC mutants R-HSA-4839744 4.499830e-01 0.347 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.499830e-01 0.347 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.499830e-01 0.347 0 0
Suppression of apoptosis R-HSA-9635465 4.499830e-01 0.347 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.499830e-01 0.347 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.499830e-01 0.347 0 0
Rab regulation of trafficking R-HSA-9007101 4.564405e-01 0.341 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.568921e-01 0.340 0 0
Mismatch Repair R-HSA-5358508 4.568921e-01 0.340 0 0
PKA activation R-HSA-163615 4.568921e-01 0.340 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.568921e-01 0.340 0 0
PKA activation in glucagon signalling R-HSA-164378 4.568921e-01 0.340 0 0
Polo-like kinase mediated events R-HSA-156711 4.568921e-01 0.340 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.568921e-01 0.340 0 0
Tie2 Signaling R-HSA-210993 4.568921e-01 0.340 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.594926e-01 0.338 0 0
G alpha (12/13) signalling events R-HSA-416482 4.596141e-01 0.338 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.605516e-01 0.337 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.608846e-01 0.336 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.639236e-01 0.334 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.713737e-01 0.327 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.780321e-01 0.321 0 0
HCN channels R-HSA-1296061 4.794760e-01 0.319 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.794760e-01 0.319 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.794760e-01 0.319 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.794760e-01 0.319 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.794760e-01 0.319 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.794760e-01 0.319 0 0
Regulation of gap junction activity R-HSA-191650 4.794760e-01 0.319 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.794760e-01 0.319 0 0
Alanine metabolism R-HSA-8964540 4.794760e-01 0.319 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.794760e-01 0.319 0 0
GABA synthesis R-HSA-888568 4.794760e-01 0.319 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.794760e-01 0.319 0 0
NADE modulates death signalling R-HSA-205025 4.794760e-01 0.319 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.794760e-01 0.319 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.811909e-01 0.318 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.811909e-01 0.318 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.828686e-01 0.316 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.828686e-01 0.316 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.828686e-01 0.316 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.828686e-01 0.316 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.828686e-01 0.316 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.828686e-01 0.316 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.844902e-01 0.315 0 0
Maturation of nucleoprotein R-HSA-9694631 4.844902e-01 0.315 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.844902e-01 0.315 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.854358e-01 0.314 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.854358e-01 0.314 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.854358e-01 0.314 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.854358e-01 0.314 0 0
Signaling by AXIN mutants R-HSA-4839735 4.854358e-01 0.314 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.854358e-01 0.314 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.854358e-01 0.314 0 0
Mitochondrial protein import R-HSA-1268020 4.924742e-01 0.308 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.980593e-01 0.303 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.007283e-01 0.300 0 0
Triglyceride catabolism R-HSA-163560 5.015555e-01 0.300 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.049912e-01 0.297 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.058312e-01 0.296 0 0
Pyroptosis R-HSA-5620971 5.058312e-01 0.296 0 0
Toll-like Receptor Cascades R-HSA-168898 5.155538e-01 0.288 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.163152e-01 0.287 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.163152e-01 0.287 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.194289e-01 0.284 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.194289e-01 0.284 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.194289e-01 0.284 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.194289e-01 0.284 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.194289e-01 0.284 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.194289e-01 0.284 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.194289e-01 0.284 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.194289e-01 0.284 0 0
MET activates RAS signaling R-HSA-8851805 5.194289e-01 0.284 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.194289e-01 0.284 0 0
Regulation of insulin secretion R-HSA-422356 5.225414e-01 0.282 0 0
Ion transport by P-type ATPases R-HSA-936837 5.238425e-01 0.281 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.283272e-01 0.277 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.283272e-01 0.277 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.299174e-01 0.276 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.331572e-01 0.273 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.331572e-01 0.273 0 0
PTK6 Down-Regulation R-HSA-8849472 5.331572e-01 0.273 0 0
Reelin signalling pathway R-HSA-8866376 5.331572e-01 0.273 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.331572e-01 0.273 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.331572e-01 0.273 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.331572e-01 0.273 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.331572e-01 0.273 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.331572e-01 0.273 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.331572e-01 0.273 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 5.343094e-01 0.272 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.375390e-01 0.270 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.375390e-01 0.270 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.375390e-01 0.270 0 0
MET promotes cell motility R-HSA-8875878 5.412936e-01 0.267 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.412936e-01 0.267 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.450749e-01 0.264 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.503104e-01 0.259 0 0
Interleukin-37 signaling R-HSA-9008059 5.503104e-01 0.259 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.518863e-01 0.258 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.518863e-01 0.258 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.518863e-01 0.258 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.518863e-01 0.258 0 0
Processing of SMDT1 R-HSA-8949664 5.518863e-01 0.258 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.518863e-01 0.258 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.518863e-01 0.258 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.518863e-01 0.258 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.520146e-01 0.258 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.605973e-01 0.251 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.605973e-01 0.251 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.628628e-01 0.250 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.628628e-01 0.250 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.628628e-01 0.250 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.649552e-01 0.248 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.794841e-01 0.237 0 0
Interleukin-2 family signaling R-HSA-451927 5.794841e-01 0.237 0 0
Plus-strand DNA synthesis R-HSA-164525 5.813052e-01 0.236 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.813052e-01 0.236 0 0
Phosphorylation of Emi1 R-HSA-176417 5.813052e-01 0.236 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.813052e-01 0.236 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.813052e-01 0.236 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.813052e-01 0.236 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.813052e-01 0.236 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.813052e-01 0.236 0 0
PKB-mediated events R-HSA-109703 5.813052e-01 0.236 0 0
PDE3B signalling R-HSA-165160 5.813052e-01 0.236 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.813052e-01 0.236 0 0
Synthesis of PS R-HSA-1483101 5.813052e-01 0.236 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.813052e-01 0.236 0 0
Signaling by MST1 R-HSA-8852405 5.813052e-01 0.236 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.813052e-01 0.236 0 0
Removal of the Flap Intermediate R-HSA-69166 5.827633e-01 0.235 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.827633e-01 0.235 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.827633e-01 0.235 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.827633e-01 0.235 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.827633e-01 0.235 0 0
Signal regulatory protein family interactions R-HSA-391160 5.827633e-01 0.235 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.838122e-01 0.234 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.842890e-01 0.233 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.864614e-01 0.232 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.873230e-01 0.231 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.873230e-01 0.231 0 0
Protein localization R-HSA-9609507 5.876092e-01 0.231 0 0
Inositol phosphate metabolism R-HSA-1483249 5.903438e-01 0.229 0 0
ABC transporter disorders R-HSA-5619084 5.907977e-01 0.229 0 0
Extension of Telomeres R-HSA-180786 5.928684e-01 0.227 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.965981e-01 0.224 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.979287e-01 0.223 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.988260e-01 0.223 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.108865e-01 0.214 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.120406e-01 0.213 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.120406e-01 0.213 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.120406e-01 0.213 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.120406e-01 0.213 0 0
Protein lipoylation R-HSA-9857492 6.120406e-01 0.213 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.120406e-01 0.213 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.128190e-01 0.213 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.128190e-01 0.213 0 0
COPII-mediated vesicle transport R-HSA-204005 6.131050e-01 0.212 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.131050e-01 0.212 0 0
HIV Transcription Initiation R-HSA-167161 6.159095e-01 0.210 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.159095e-01 0.210 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.159095e-01 0.210 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.159095e-01 0.210 0 0
The phototransduction cascade R-HSA-2514856 6.194871e-01 0.208 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.213118e-01 0.207 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.244900e-01 0.204 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.244900e-01 0.204 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.244900e-01 0.204 0 0
Uncoating of the HIV Virion R-HSA-162585 6.244900e-01 0.204 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.244900e-01 0.204 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.244900e-01 0.204 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.244900e-01 0.204 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.244900e-01 0.204 0 0
Nef and signal transduction R-HSA-164944 6.244900e-01 0.204 0 0
MET Receptor Activation R-HSA-6806942 6.244900e-01 0.204 0 0
HDL clearance R-HSA-8964011 6.244900e-01 0.204 0 0
Neurofascin interactions R-HSA-447043 6.244900e-01 0.204 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.324166e-01 0.199 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.324166e-01 0.199 1 1
Miscellaneous transport and binding events R-HSA-5223345 6.324166e-01 0.199 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.334082e-01 0.198 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.335301e-01 0.198 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.335301e-01 0.198 0 0
Interleukin-6 family signaling R-HSA-6783589 6.335301e-01 0.198 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.335301e-01 0.198 0 0
Mitochondrial RNA degradation R-HSA-9836573 6.335301e-01 0.198 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.335301e-01 0.198 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.354250e-01 0.197 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.397196e-01 0.194 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.397196e-01 0.194 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.397196e-01 0.194 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.397196e-01 0.194 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 6.408427e-01 0.193 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.504098e-01 0.187 0 0
eNOS activation R-HSA-203615 6.513627e-01 0.186 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.513627e-01 0.186 0 0
Stimuli-sensing channels R-HSA-2672351 6.532628e-01 0.185 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.552395e-01 0.184 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.552395e-01 0.184 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.632229e-01 0.178 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.632229e-01 0.178 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.632229e-01 0.178 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.632229e-01 0.178 0 0
Recycling of eIF2:GDP R-HSA-72731 6.632229e-01 0.178 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.632229e-01 0.178 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.632229e-01 0.178 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.632229e-01 0.178 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.632229e-01 0.178 0 0
VLDL clearance R-HSA-8964046 6.632229e-01 0.178 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.632229e-01 0.178 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.632229e-01 0.178 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.632229e-01 0.178 0 0
Netrin mediated repulsion signals R-HSA-418886 6.632229e-01 0.178 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.632229e-01 0.178 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.658187e-01 0.177 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.658187e-01 0.177 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.658187e-01 0.177 0 0
Galactose catabolism R-HSA-70370 6.658187e-01 0.177 0 0
Coenzyme A biosynthesis R-HSA-196783 6.658187e-01 0.177 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.658187e-01 0.177 0 0
DAP12 interactions R-HSA-2172127 6.669024e-01 0.176 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.706931e-01 0.173 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.706931e-01 0.173 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.760085e-01 0.170 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.760085e-01 0.170 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.760085e-01 0.170 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.760085e-01 0.170 0 0
TRP channels R-HSA-3295583 6.760085e-01 0.170 0 0
Iron uptake and transport R-HSA-917937 6.802579e-01 0.167 0 0
Signaling by NOTCH3 R-HSA-9012852 6.807911e-01 0.167 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.828771e-01 0.166 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.872569e-01 0.163 0 0
RNA Polymerase III Transcription R-HSA-74158 6.872569e-01 0.163 0 0
G1/S-Specific Transcription R-HSA-69205 6.872569e-01 0.163 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.903692e-01 0.161 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.903692e-01 0.161 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.903692e-01 0.161 0 0
Specification of primordial germ cells R-HSA-9827857 6.903692e-01 0.161 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.903692e-01 0.161 0 0
Integration of energy metabolism R-HSA-163685 6.910903e-01 0.160 0 0
NRAGE signals death through JNK R-HSA-193648 6.950683e-01 0.158 0 0
Neddylation R-HSA-8951664 6.957824e-01 0.158 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.958375e-01 0.157 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.958375e-01 0.157 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.958375e-01 0.157 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.979626e-01 0.156 0 0
Minus-strand DNA synthesis R-HSA-164516 6.979626e-01 0.156 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.979626e-01 0.156 0 0
phospho-PLA2 pathway R-HSA-111995 6.979626e-01 0.156 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.979626e-01 0.156 0 0
MET receptor recycling R-HSA-8875656 6.979626e-01 0.156 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.979626e-01 0.156 0 0
Interleukin-9 signaling R-HSA-8985947 6.979626e-01 0.156 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.979626e-01 0.156 0 0
Regulation by c-FLIP R-HSA-3371378 6.979626e-01 0.156 0 0
Activation of RAS in B cells R-HSA-1169092 6.979626e-01 0.156 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.979626e-01 0.156 0 0
Fructose biosynthesis R-HSA-5652227 6.979626e-01 0.156 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.979626e-01 0.156 0 0
Dimerization of procaspase-8 R-HSA-69416 6.979626e-01 0.156 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.979626e-01 0.156 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.979626e-01 0.156 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.979626e-01 0.156 0 0
RSK activation R-HSA-444257 6.979626e-01 0.156 0 0
Sodium/Proton exchangers R-HSA-425986 6.979626e-01 0.156 0 0
Alpha-defensins R-HSA-1462054 6.979626e-01 0.156 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.983275e-01 0.156 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.983275e-01 0.156 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.995467e-01 0.155 0 0
Kidney development R-HSA-9830369 7.063622e-01 0.151 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.134128e-01 0.147 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.134128e-01 0.147 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.134128e-01 0.147 0 0
Apoptotic factor-mediated response R-HSA-111471 7.134128e-01 0.147 0 0
Nephron development R-HSA-9831926 7.134128e-01 0.147 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.134128e-01 0.147 0 0
Telomere Extension By Telomerase R-HSA-171319 7.147332e-01 0.146 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.147332e-01 0.146 0 0
Cardiac conduction R-HSA-5576891 7.260821e-01 0.139 0 0
Sensory processing of sound R-HSA-9659379 7.284483e-01 0.138 0 0
Interleukin-21 signaling R-HSA-9020958 7.291207e-01 0.137 0 0
CASP8 activity is inhibited R-HSA-5218900 7.291207e-01 0.137 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.291207e-01 0.137 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.291207e-01 0.137 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.291207e-01 0.137 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.291207e-01 0.137 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.291207e-01 0.137 0 0
mRNA Editing R-HSA-75072 7.291207e-01 0.137 0 0
Calcineurin activates NFAT R-HSA-2025928 7.291207e-01 0.137 0 0
Expression of NOTCH2NL genes R-HSA-9911233 7.291207e-01 0.137 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.291207e-01 0.137 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.291207e-01 0.137 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.291207e-01 0.137 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.291207e-01 0.137 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.327072e-01 0.135 0 0
Glucagon-type ligand receptors R-HSA-420092 7.327072e-01 0.135 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.349991e-01 0.134 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.349991e-01 0.134 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.349991e-01 0.134 0 0
Other interleukin signaling R-HSA-449836 7.349991e-01 0.134 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.360464e-01 0.133 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.360464e-01 0.133 0 0
Signaling by TGFB family members R-HSA-9006936 7.367926e-01 0.133 0 0
Ion channel transport R-HSA-983712 7.398536e-01 0.131 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.459648e-01 0.127 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.478333e-01 0.126 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.478333e-01 0.126 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.478333e-01 0.126 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.478333e-01 0.126 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.478333e-01 0.126 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.497758e-01 0.125 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.497758e-01 0.125 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.509712e-01 0.124 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.509712e-01 0.124 0 0
HIV Transcription Elongation R-HSA-167169 7.509712e-01 0.124 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.551835e-01 0.122 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.551835e-01 0.122 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.551835e-01 0.122 0 0
Creatine metabolism R-HSA-71288 7.551835e-01 0.122 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.570661e-01 0.121 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.570661e-01 0.121 0 0
Interleukin-27 signaling R-HSA-9020956 7.570661e-01 0.121 0 0
Maturation of spike protein R-HSA-9683686 7.570661e-01 0.121 0 0
Sperm Motility And Taxes R-HSA-1300642 7.570661e-01 0.121 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.570661e-01 0.121 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.570661e-01 0.121 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.570661e-01 0.121 0 0
Aquaporin-mediated transport R-HSA-445717 7.599344e-01 0.119 0 0
ABC-family proteins mediated transport R-HSA-382556 7.651610e-01 0.116 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.659586e-01 0.116 0 0
Signaling by PDGF R-HSA-186797 7.716026e-01 0.113 0 0
Disease R-HSA-1643685 7.729839e-01 0.112 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.740255e-01 0.111 0 0
G-protein activation R-HSA-202040 7.740255e-01 0.111 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.740255e-01 0.111 0 0
Lagging Strand Synthesis R-HSA-69186 7.740255e-01 0.111 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.740255e-01 0.111 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.788602e-01 0.109 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.788602e-01 0.109 0 0
Neurexins and neuroligins R-HSA-6794361 7.799616e-01 0.108 0 0
G0 and Early G1 R-HSA-1538133 7.812785e-01 0.107 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.812785e-01 0.107 0 0
Signaling by WNT in cancer R-HSA-4791275 7.812785e-01 0.107 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.812785e-01 0.107 0 0
vRNP Assembly R-HSA-192905 7.821301e-01 0.107 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.821301e-01 0.107 0 0
Transport of RCbl within the body R-HSA-9758890 7.821301e-01 0.107 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.821301e-01 0.107 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.828418e-01 0.106 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.837936e-01 0.106 0 0
Signaling by FGFR in disease R-HSA-1226099 7.866780e-01 0.104 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.915871e-01 0.102 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.915871e-01 0.102 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.915871e-01 0.102 0 0
Ribavirin ADME R-HSA-9755088 7.915871e-01 0.102 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.928377e-01 0.101 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.046094e-01 0.094 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.046094e-01 0.094 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.046094e-01 0.094 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.046094e-01 0.094 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.046094e-01 0.094 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.046094e-01 0.094 0 0
Signaling by NOTCH1 R-HSA-1980143 8.063165e-01 0.093 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.079319e-01 0.093 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.079319e-01 0.093 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.079319e-01 0.093 0 0
LDL clearance R-HSA-8964038 8.079319e-01 0.093 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.079319e-01 0.093 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.094328e-01 0.092 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.126795e-01 0.090 0 0
tRNA processing R-HSA-72306 8.147829e-01 0.089 0 0
Signal amplification R-HSA-392518 8.223231e-01 0.085 0 0
Interleukin-20 family signaling R-HSA-8854691 8.231240e-01 0.085 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.231240e-01 0.085 0 0
Platelet homeostasis R-HSA-418346 8.242219e-01 0.084 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.247706e-01 0.084 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.247706e-01 0.084 0 0
Repression of WNT target genes R-HSA-4641265 8.247706e-01 0.084 0 0
Interleukin-35 Signalling R-HSA-8984722 8.247706e-01 0.084 0 0
Acetylation R-HSA-156582 8.247706e-01 0.084 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.247706e-01 0.084 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.247706e-01 0.084 0 0
Leading Strand Synthesis R-HSA-69109 8.247706e-01 0.084 0 0
Polymerase switching R-HSA-69091 8.247706e-01 0.084 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.247706e-01 0.084 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.247706e-01 0.084 0 0
OAS antiviral response R-HSA-8983711 8.247706e-01 0.084 0 0
Somitogenesis R-HSA-9824272 8.271561e-01 0.082 0 0
Interferon alpha/beta signaling R-HSA-909733 8.277008e-01 0.082 0 0
PERK regulates gene expression R-HSA-381042 8.344614e-01 0.079 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.372272e-01 0.077 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.372272e-01 0.077 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.372272e-01 0.077 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.428525e-01 0.074 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.428525e-01 0.074 0 0
Formation of axial mesoderm R-HSA-9796292 8.428525e-01 0.074 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.428525e-01 0.074 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.428525e-01 0.074 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.428525e-01 0.074 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.428525e-01 0.074 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.428525e-01 0.074 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.458785e-01 0.073 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.503043e-01 0.070 0 0
G protein gated Potassium channels R-HSA-1296059 8.503043e-01 0.070 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.503043e-01 0.070 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.503043e-01 0.070 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.503043e-01 0.070 0 0
TGFBR3 expression R-HSA-9839394 8.503043e-01 0.070 0 0
Laminin interactions R-HSA-3000157 8.503043e-01 0.070 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.503043e-01 0.070 0 0
Hyaluronan degradation R-HSA-2160916 8.503043e-01 0.070 0 0
Formation of the nephric duct R-HSA-9830364 8.503043e-01 0.070 0 0
Peroxisomal protein import R-HSA-9033241 8.523751e-01 0.069 0 0
Triglyceride metabolism R-HSA-8979227 8.523751e-01 0.069 0 0
Gluconeogenesis R-HSA-70263 8.573435e-01 0.067 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.590695e-01 0.066 0 0
Biosynthesis of protectins R-HSA-9018681 8.590695e-01 0.066 0 0
Hydrolysis of LPC R-HSA-1483115 8.590695e-01 0.066 0 0
cGMP effects R-HSA-418457 8.590695e-01 0.066 0 0
Physiological factors R-HSA-5578768 8.590695e-01 0.066 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.590695e-01 0.066 0 0
Malate-aspartate shuttle R-HSA-9856872 8.590695e-01 0.066 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.590695e-01 0.066 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.590695e-01 0.066 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.590695e-01 0.066 0 0
Zinc transporters R-HSA-435354 8.590695e-01 0.066 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.590695e-01 0.066 0 0
RAB geranylgeranylation R-HSA-8873719 8.608994e-01 0.065 0 0
tRNA Aminoacylation R-HSA-379724 8.608994e-01 0.065 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.608994e-01 0.065 0 0
Metabolism of polyamines R-HSA-351202 8.608994e-01 0.065 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.624170e-01 0.064 0 0
Myogenesis R-HSA-525793 8.624170e-01 0.064 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.624170e-01 0.064 0 0
Parasitic Infection Pathways R-HSA-9824443 8.665598e-01 0.062 0 0
Leishmania infection R-HSA-9658195 8.665598e-01 0.062 0 0
Elastic fibre formation R-HSA-1566948 8.666722e-01 0.062 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.666722e-01 0.062 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.690070e-01 0.061 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.736138e-01 0.059 0 0
Signaling by Activin R-HSA-1502540 8.736138e-01 0.059 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.736138e-01 0.059 0 0
Protein repair R-HSA-5676934 8.736138e-01 0.059 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.736138e-01 0.059 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.736138e-01 0.059 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.736138e-01 0.059 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.736138e-01 0.059 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.736138e-01 0.059 0 0
Other semaphorin interactions R-HSA-416700 8.736138e-01 0.059 0 0
Cristae formation R-HSA-8949613 8.736250e-01 0.059 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.736250e-01 0.059 0 0
Pentose phosphate pathway R-HSA-71336 8.761108e-01 0.057 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.761108e-01 0.057 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.779206e-01 0.057 0 0
RSV-host interactions R-HSA-9833110 8.824722e-01 0.054 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.826387e-01 0.054 0 0
Formation of the cornified envelope R-HSA-6809371 8.832732e-01 0.054 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.839859e-01 0.054 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.839859e-01 0.054 0 0
Insulin receptor recycling R-HSA-77387 8.839859e-01 0.054 0 0
Metabolism of proteins R-HSA-392499 8.843615e-01 0.053 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.849516e-01 0.053 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.849516e-01 0.053 0 0
Diseases of Immune System R-HSA-5260271 8.849516e-01 0.053 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.849516e-01 0.053 0 0
Killing mechanisms R-HSA-9664420 8.866579e-01 0.052 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.866579e-01 0.052 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.866579e-01 0.052 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.866579e-01 0.052 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.866579e-01 0.052 0 0
Attachment and Entry R-HSA-9678110 8.866579e-01 0.052 0 0
Mitochondrial Uncoupling R-HSA-166187 8.866579e-01 0.052 0 0
Differentiation of T cells R-HSA-9945266 8.866579e-01 0.052 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.866579e-01 0.052 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.867642e-01 0.052 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.905069e-01 0.050 0 0
Maturation of spike protein R-HSA-9694548 8.932246e-01 0.049 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.935552e-01 0.049 0 0
Platelet calcium homeostasis R-HSA-418360 8.935552e-01 0.049 0 0
Potassium Channels R-HSA-1296071 8.944076e-01 0.048 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.948532e-01 0.048 0 0
Glycine degradation R-HSA-6783984 8.983564e-01 0.047 0 0
Fibronectin matrix formation R-HSA-1566977 8.983564e-01 0.047 0 0
Passive transport by Aquaporins R-HSA-432047 8.983564e-01 0.047 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.983564e-01 0.047 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.023858e-01 0.045 0 0
Neurotransmitter clearance R-HSA-112311 9.023858e-01 0.045 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.023858e-01 0.045 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.023858e-01 0.045 0 0
Integrin cell surface interactions R-HSA-216083 9.049209e-01 0.043 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.088481e-01 0.042 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.088481e-01 0.042 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.088481e-01 0.042 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.088481e-01 0.042 0 0
Choline catabolism R-HSA-6798163 9.088481e-01 0.042 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.088481e-01 0.042 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.103882e-01 0.041 0 0
Cargo concentration in the ER R-HSA-5694530 9.105282e-01 0.041 0 0
TBC/RABGAPs R-HSA-8854214 9.149292e-01 0.039 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.182574e-01 0.037 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.182574e-01 0.037 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.182574e-01 0.037 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.182574e-01 0.037 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.182574e-01 0.037 0 0
Leishmania phagocytosis R-HSA-9664417 9.192131e-01 0.037 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.192131e-01 0.037 0 0
Parasite infection R-HSA-9664407 9.192131e-01 0.037 0 0
Surfactant metabolism R-HSA-5683826 9.212191e-01 0.036 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.212191e-01 0.036 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.255088e-01 0.034 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.262511e-01 0.033 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.266959e-01 0.033 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.266959e-01 0.033 0 0
Pyrimidine biosynthesis R-HSA-500753 9.266959e-01 0.033 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.266959e-01 0.033 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.266959e-01 0.033 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.266959e-01 0.033 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.266959e-01 0.033 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.266959e-01 0.033 0 0
Extracellular matrix organization R-HSA-1474244 9.268468e-01 0.033 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.275874e-01 0.033 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.298544e-01 0.032 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.312933e-01 0.031 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.325292e-01 0.030 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.325292e-01 0.030 0 0
Signaling by TGFBR3 R-HSA-9839373 9.325395e-01 0.030 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.340526e-01 0.030 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.342637e-01 0.030 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.342637e-01 0.030 0 0
Signaling by NODAL R-HSA-1181150 9.342637e-01 0.030 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.342637e-01 0.030 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.342637e-01 0.030 0 0
Pregnenolone biosynthesis R-HSA-196108 9.342637e-01 0.030 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.345904e-01 0.029 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.371370e-01 0.028 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.371370e-01 0.028 0 0
Hyaluronan metabolism R-HSA-2142845 9.371370e-01 0.028 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.376193e-01 0.028 0 0
Synthesis of PC R-HSA-1483191 9.376193e-01 0.028 0 0
Ca2+ pathway R-HSA-4086398 9.388343e-01 0.027 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.388343e-01 0.027 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.410506e-01 0.026 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.410506e-01 0.026 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.410506e-01 0.026 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.410506e-01 0.026 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.410506e-01 0.026 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.412453e-01 0.026 0 0
Metal ion SLC transporters R-HSA-425410 9.423434e-01 0.026 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.425068e-01 0.026 0 0
Post-translational protein modification R-HSA-597592 9.454120e-01 0.024 0 0
Innate Immune System R-HSA-168249 9.456281e-01 0.024 0 0
Attachment and Entry R-HSA-9694614 9.471372e-01 0.024 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.471372e-01 0.024 0 0
Gastrulation R-HSA-9758941 9.499880e-01 0.022 0 0
Azathioprine ADME R-HSA-9748787 9.508111e-01 0.022 0 0
G alpha (s) signalling events R-HSA-418555 9.510345e-01 0.022 0 0
Voltage gated Potassium channels R-HSA-1296072 9.519650e-01 0.021 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.519650e-01 0.021 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.525956e-01 0.021 0 0
Notch-HLH transcription pathway R-HSA-350054 9.525956e-01 0.021 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.525956e-01 0.021 0 0
Fructose metabolism R-HSA-5652084 9.525956e-01 0.021 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.525956e-01 0.021 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.525956e-01 0.021 0 0
Cellular hexose transport R-HSA-189200 9.525956e-01 0.021 0 0
Signaling by KIT in disease R-HSA-9669938 9.525956e-01 0.021 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.525956e-01 0.021 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.532540e-01 0.021 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.561175e-01 0.019 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.563386e-01 0.019 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.569545e-01 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.574907e-01 0.019 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.574907e-01 0.019 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.613616e-01 0.017 0 0
Nucleotide biosynthesis R-HSA-8956320 9.613616e-01 0.017 0 0
Complex III assembly R-HSA-9865881 9.618806e-01 0.017 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.622878e-01 0.017 0 0
SLC transporter disorders R-HSA-5619102 9.639664e-01 0.016 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.658174e-01 0.015 0 0
Fertilization R-HSA-1187000 9.658174e-01 0.015 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.658174e-01 0.015 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.666107e-01 0.015 0 0
MET activates PTK2 signaling R-HSA-8874081 9.693478e-01 0.014 0 0
Urea cycle R-HSA-70635 9.693478e-01 0.014 0 0
Sphingolipid catabolism R-HSA-9845614 9.693478e-01 0.014 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.693478e-01 0.014 0 0
Mitochondrial protein degradation R-HSA-9837999 9.693502e-01 0.014 0 0
Collagen formation R-HSA-1474290 9.693502e-01 0.014 0 0
Dectin-2 family R-HSA-5621480 9.721481e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.721481e-01 0.012 0 0
Activation of GABAB receptors R-HSA-991365 9.722159e-01 0.012 0 0
GABA B receptor activation R-HSA-977444 9.722159e-01 0.012 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.725138e-01 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.725138e-01 0.012 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.747788e-01 0.011 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.747788e-01 0.011 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.749288e-01 0.011 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.753529e-01 0.011 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.753529e-01 0.011 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.767868e-01 0.010 0 0
Thyroxine biosynthesis R-HSA-209968 9.778990e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.778990e-01 0.010 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.778990e-01 0.010 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.778990e-01 0.010 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.801821e-01 0.009 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.809773e-01 0.008 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.816467e-01 0.008 0 0
Heme signaling R-HSA-9707616 9.816467e-01 0.008 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.822295e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.826308e-01 0.008 0 0
Phospholipid metabolism R-HSA-1483257 9.836353e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.837307e-01 0.007 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.844134e-01 0.007 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.845017e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.855234e-01 0.006 0 0
Cardiogenesis R-HSA-9733709 9.857119e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.857119e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.863480e-01 0.006 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.868240e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.869283e-01 0.006 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.871883e-01 0.006 0 0
Heme degradation R-HSA-189483 9.871883e-01 0.006 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.885122e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.889875e-01 0.005 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.896994e-01 0.004 0 0
Adipogenesis R-HSA-9843745 9.902071e-01 0.004 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.904218e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.907639e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.907639e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.909193e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.915016e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.917185e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.917185e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.917976e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.933421e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.934569e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.940303e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.940303e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.940303e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.947285e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.947497e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.949191e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.949191e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.953857e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.953982e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.955296e-01 0.002 1 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.956970e-01 0.002 0 0
Defensins R-HSA-1461973 9.961419e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.961963e-01 0.002 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.964741e-01 0.002 0 0
Methylation R-HSA-156581 9.965409e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.965409e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.968986e-01 0.001 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.970507e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.979959e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.980931e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.982032e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.982544e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.983891e-01 0.001 0 0
Mitochondrial biogenesis R-HSA-1592230 9.985484e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.985675e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.987596e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.987789e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.990059e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.990669e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.992479e-01 0.000 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.992501e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992901e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.996414e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.996805e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997195e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997195e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997691e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.997698e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.997979e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997979e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998189e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998231e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.998341e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998376e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.998594e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998695e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998745e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999158e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999245e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999245e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999393e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999466e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999747e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999874e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999890e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999895e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999904e-01 0.000 1 0
Peptide hormone metabolism R-HSA-2980736 9.999906e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999915e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999932e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999959e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999961e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999982e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999992e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999994e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999994e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999996e-01 0.000 1 0
Complement cascade R-HSA-166658 9.999997e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways