AKT1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00429	S616	PSP	DNM1L DLP1 DRP1	SKAEELLAEEKsKPIPIMPAsPQKGHAVNLLDVPVPVARKL
O14492	S598	SIGNOR	SH2B2 APS	SGPAPPRPVEGQLSARsRsNsAERLLEAVAATAAEEPPEAA
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14617	S658	Sugiyama	AP3D1 PRO0039	DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14686	S1331	PSP	KMT2D ALR MLL2 MLL4	RRRPRGGAHGGRGRGRARLKsTASSIETLVVADIDSSPSKE
O14745	T156	PSP	NHERF1 NHERF SLC9A3R1	EPREADKSHPEQRELRPRLCtMKKGPsGYGFNLHSDKSKPG
O14746	S227	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TERT EST2 TCS1 TRT	VREAGVPLGLPAPGARRRGGsASRSLPLPKRPRRGAAPEPE
O14746	S824	SIGNOR\|ELM\|EPSD\|PSP	TERT EST2 TCS1 TRT	GLFDVFLRFMCHHAVRIRGKsYVQCQGIPQGSILSTLLCSL
O14757	S280	SIGNOR\|ELM\|EPSD\|PSP	CHEK1 CHK1	KKDRWYNKPLKKGAKRPRVtsGGVsEsPsGFsKHIQsNLDF
O14939	T175	PSP	PLD2	STRHAASKQKYLENyLNRLLtMSFyRNYHAMTEFLEVSQLS
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15013	S1287	Sugiyama	ARHGEF10 KIAA0294	WLGDSLGSMTQKsDLssssGsLsLsHGsssLEHRSEDsTIy
O15111	T23	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHUK IKKA TCF16	RPPGLRPGAGGPWEMRERLGtGGFGNVCLYQHRELDLKIAI
O15119	S719	SIGNOR	TBX3	LSsssMsLsPKLCAEKEAATsELQsIQRLVSGLEAKPDRsR
O15143	S328	Sugiyama	ARPC1B ARC41	KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT
O15151	S342	iPTMNet	MDM4 MDMX	RCWALRKDWYSDCSKLtHsLstsDItAIPEKENEGNDVPDC
O15151	S367	SIGNOR\|EPSD\|PSP	MDM4 MDMX	tAIPEKENEGNDVPDCRRtIsAPVVRPKDAYIKKENSKLFD
O15360	S1149	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FANCA FAA FACA FANCH	DITAHFFRGLLNACLRSRDPsLMVDFILAKCQTKCPLILTS
O15519	S273	GPS6\|SIGNOR\|EPSD\|PSP	CFLAR CASH CASP8AP1 CLARP MRIT	ICLIIDCIGNETELLRDTFTsLGYEVQKFLHLSMHGISQIL
O43175	T78	Sugiyama	PHGDH PGDH3	KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43390	T137	Sugiyama	HNRNPR HNRPR	ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43464	S212	SIGNOR\|EPSD\|PSP	HTRA2 OMI PRSS25	LIVTNAHVVADRRRVRVRLLsGDtYEAVVTAVDPVADIATL
O43521	S87	GPS6\|SIGNOR\|EPSD\|PSP	BCL2L11 BIM	PAsPGPFATRsPLFIFMRRSsLLSRsssGYFsFDTDRsPAP
O43524	S253	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524	S315	SIGNOR	FOXO3 FKHRL1 FOXO3A	PtSRssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDE
O43524	T32	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO3 FKHRL1 FOXO3A	sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O43847	S94	Sugiyama	NRDC NRD1	ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O60271	T595	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	NLKYNAPTSHVtPsVKKRsstLsQLPGDKSKAFDFLSEETE
O60285	S600	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NUAK1 ARK5 KIAA0537 OMPHK1	SDSFDLLDLQENRPARQRIRsCVsAENFLQIQDFEGLQNRP
O60293	S42	Sugiyama	ZFC3H1 CCDC131 KIAA0546 PSRC2	LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60331	S555	EPSD\|PSP	PIP5K1C KIAA0589	IPERSPsETSEQPRYRRRtQssGQDGRPQEEPPAEEDLQQI
O60343	S318	EPSD\|PSP	TBC1D4 AS160 KIAA0603	ERILEDsGFDEQQEFRsRCssVTGVQRRVHEGSQKSQPRRR
O60343	S341	PSP	TBC1D4 AS160 KIAA0603	GVQRRVHEGSQKSQPRRRHAsAPsHVQPSDSEKNRTMLFQV
O60343	S570	PSP	TBC1D4 AS160 KIAA0603	ssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGsVD
O60343	S588	GPS6\|SIGNOR\|EPSD\|PSP	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60343	S666	PSP	TBC1D4 AS160 KIAA0603	PPsstKRKLNLQDGRAQGVRsPLLRQSssEQCSNLSSVRRM
O60343	S751	PSP\|Sugiyama	TBC1D4 AS160 KIAA0603	EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS
O60343	S757	Sugiyama	TBC1D4 AS160 KIAA0603	ASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQRIF
O60343	T568	PSP	TBC1D4 AS160 KIAA0603	AtssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGs
O60343	T642	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	TBC1D4 AS160 KIAA0603	AWQTFPEEDSDSPQFRRRAHtFsHPPsstKRKLNLQDGRAQ
O60493	S72	Sugiyama	SNX3	RVKTNLPIFKLKESTVRRRysDFEWLRSELERESKVVVPPL
O60506	T134	Sugiyama	SYNCRIP HNRPQ NSAP1	DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60825	S466	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PFKFB2	RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O60825	S483	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PFKFB2	RRNsFtPLsssNtIRRPRNYsVGsRPLKPLsPLRAQDMQEG
O60841	S178	Sugiyama	EIF5B IF2 KIAA0741	NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75030	S516	SIGNOR\|EPSD\|PSP	MITF BHLHE32	tDPLLssVsPGAsKTSSRRssMsMEETEHTC__________
O75140	S1530	PSP	DEPDC5 KIAA0645	FLQLPYSKRKFSGQQRRRRNstsstNQNMFCEERVGYNWAY
O75376	S1450	SIGNOR\|EPSD\|PSP	NCOR1 KIAA1047	VERGKYEDVKAGETVRSRHtsVVsSGPSVLRSTLHEAPKAQ
O75390	S97	Sugiyama	CS	GLVyEtsVLDPDEGIRFRGFsIPECQKLLPKAKGGEEPLPE
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75937	S81	Sugiyama	DNAJC8 SPF31 HSPC315 HSPC331	VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95453	S557	Sugiyama	PARN DAN	KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95544	S44	GPS6	NADK	SACHGDETWSYNHPIRGRAKsRsLsAsPALGsTKEFRRtRs
O95544	S46	GPS6	NADK	CHGDETWSYNHPIRGRAKsRsLsAsPALGsTKEFRRtRsLH
O95544	S48	GPS6	NADK	GDETWSYNHPIRGRAKsRsLsAsPALGsTKEFRRtRsLHGP
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95835	S464	Sugiyama	LATS1 WARTS	SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
O95999	S218	GPS6\|EPSD\|PSP	BCL10 CIPER CLAP	PGAPPLPPDLQLEEEGTCANsSEMFLPLRSRTVsRQ_____
O95999	S231	GPS6\|EPSD\|PSP	BCL10 CIPER CLAP	EEGTCANsSEMFLPLRSRTVsRQ__________________
O96028	S172	EPSD\|PSP	NSD2 KIAA1090 MMSET TRX5 WHSC1	SQSEENGQKPENKARRNRKRsIKYDsLLEQGLVEAALVSKI
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00533	S229	EPSD\|PSP	EGFR ERBB ERBB1 HER1	KLTKIICAQQCSGRCRGKSPsDCCHNQCAAGCTGPRESDCL
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545	S301	EPSD\|PSP	LMNA LMN1	NsNLVGAAHEELQQsRIRIDsLsAQLsQLQKQLAAKEAKLR
P02545	S404	EPSD\|PSP	LMNA LMN1	EERLRLsPsPtsQRsRGRAssHssQtQGGGsVtKKRKLEst
P02545	S458	Sugiyama	LMNA LMN1	GRVAVEEVDEEGKFVRLRNKsNEDQsMGNWQIKRQNGDDPL
P03372	S104	SIGNOR	ESR1 ESR NR3A1	SEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPH
P03372	S106	SIGNOR	ESR1 ESR NR3A1	AAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQ
P03372	S118	SIGNOR	ESR1 ESR NR3A1	PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P03372	S167	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ESR1 ESR NR3A1	PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P03372	S305	EPSD\|PSP	ESR1 ESR NR3A1	DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP
P04049	S259	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAF1 RAF	tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S182	Sugiyama	ANXA1 ANX1 LPC1	RDLAKDItsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsD
P04150	S134	SIGNOR\|EPSD\|PSP	NR3C1 GRL	SGETDLKLLEEsIANLNRstsVPENPKSSASTAVSAAPTEK
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	SIGNOR\|EPSD\|PSP\|Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05106	T779	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ITGB3 GP3A	ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05455	T389	PSP	SSB	EHDEHDENGAtGPVKRAREEtDKEEPASKQQKTENGAGDQ_
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S432	PSP	KRT8 CYK8	HtKTTSGYAGGLSSAYGGLtsPGLSYSLGSSFGSGAGSSSF
P06748	S48	SIGNOR\|PSP	NPM1 NPM	DyHFKVDNDENEHQLsLRTVsLGAGAKDELHIVEAEAMNyE
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339	S37	Sugiyama	CTSD CPSD	PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07550	S345	SIGNOR	ADRB2 ADRB2R B2AR	IyCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsG
P07550	S346	SIGNOR\|ELM\|EPSD\|PSP	ADRB2 ADRB2R B2AR	yCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsGY
P07814	S1336	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN
P07814	S999	PSP	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	QKQNDGQRKDPsKNQGGGLsssGAGEGQGPKKQTRLGLEAK
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08047	S42	EPSD\|PSP	SP1 TSFP1	GGNNGGNGNGGGAFsQARssstGsssstGGGGQEsQPsPLA
P08047	S698	EPSD\|PSP	SP1 TSFP1	RtHtGEKKFACPECPKRFMRsDHLsKHIKTHQNKKGGPGVA
P08047	T679	EPSD\|PSP	SP1 TSFP1	TWSYCGKRFtRsDELQRHKRtHtGEKKFACPECPKRFMRsD
P08174	S106	Sugiyama	CD55 CR DAF	QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08670	S39	SIGNOR\|EPSD\|PSP	VIM	GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08727	S35	PSP	KRT19	FGGLGGGSVRFGPGVAFRAPsIHGGSGGRGVSVSSARFVss
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09601	S188	SIGNOR\|iPTMNet\|EPSD\|PSP	HMOX1 HO HO1	TFPNIASATKFKQLYRSRMNsLEMTPAVRQRVIEEAKTAFL
P09651	S199	SIGNOR\|EPSD\|PSP	HNRNPA1 HNRPA1	KALSKQEMAsAsssQRGRsGsGNFGGGRGGGFGGNDNFGRG
P0DMV8	S631	PSP	HSPA1A HSP72 HSPA1 HSX70	yQGAGGPGPGGFGAQGPKGGsGsGPtIEEVD__________
P10275	S215	SIGNOR\|EPSD\|PSP	AR DHTR NR3C4	QQQQQEAVSEGssSGRAREAsGAPTsSKDNyLGGTSTISDN
P10275	S792	SIGNOR\|EPSD\|PSP	AR DHTR NR3C4	NEYRMHKSRMYSQCVRMRHLsQEFGWLQITPQEFLCMKALL
P10276	S96	GPS6\|SIGNOR\|EPSD\|PSP	RARA NR1B1	PsPPPLPRIYKPCFVCQDKSsGYHYGVSACEGCKGFFRRSI
P10636	S214	GPS6	MAPT MAPTL MTBT1 TAU	GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11586	S490	Sugiyama	MTHFD1 MTHFC MTHFD	QTDKALFNRLVPSVNGVRRFsDIQIRRLKRLGIEKTDPTTL
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12755	T458	SIGNOR\|EPSD\|PSP	SKI	AVSRAPEPLATCTQPRKRKLtVDTPGAPETLAPVAAPEEDK
P13473	S155	Sugiyama	LAMP2	LTVDELLAIRIPLNDLFRCNsLSTLEKNDVVQHYWDVLVQA
P13631	S371	SIGNOR\|PSP	RARG NR1B3	DKLQEPLLEALRLYARRRRPsQPYMFPRMLMKITDLRGIsT
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13674	T364	Sugiyama	P4HA1 P4HA	IsDAEIEIVKDLAKPRLRRAtIsNPITGDLETVHYRISKsA
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598	S304	SIGNOR\|ELM\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598	S328	SIGNOR\|ELM\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14618	S202	EPSD\|PSP\|Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618	S222	PSP	PKM OIP3 PK2 PK3 PKM2	sLGsKKGVNLPGAAVDLPAVsEKDIQDLKFGVEQDVDMVFA
P14618	S37	EPSD\|PSP	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618	S97	EPSD\|PSP	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14618	T45	Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15056	S364	SIGNOR	BRAF BRAF1 RAFB1	QPFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIR
P15056	S365	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRAF BRAF1 RAFB1	PFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIRD
P15056	S428	SIGNOR	BRAF BRAF1 RAFB1	GSLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssD
P15056	S429	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRAF BRAF1 RAFB1	SLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssDD
P15056	T440	SIGNOR	BRAF BRAF1 RAFB1	PGPQRERKsssssEDRNRMKtLGRRDssDDWEIPDGQITVG
P15104	S322	Sugiyama	GLUL GLNS	GFHETSNINDFSAGVANRsAsIRIPRTVGQEKKGYFEDRRP
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15311	T567	SIGNOR	EZR VIL2	RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15559	S40	SIGNOR\|PSP	NQO1 DIA4 NMOR1	YAMKEAAAAALKKKGWEVVEsDLYAMNFNPIISRKDITGKL
P15559	T128	GPS6\|SIGNOR\|PSP	NQO1 DIA4 NMOR1	GVPAILKGWFERVFIGEFAYtYAAMYDKGPFRSKKAVLSIT
P15880	S190	Sugiyama	RPS2 RPS4	WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P15976	S310	SIGNOR\|ELM\|EPSD\|PSP	GATA1 ERYF1 GF1	QVNRPLTMRKDGIQTRNRKAsGKGKKKRGSSLGGTGAAEGP
P16220	S119	SIGNOR\|PSP	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17302	S373	PSP	GJA1 GJAL	LQPLAIVDQRPssRAssRAssRPRPDDLEI___________
P17542	T90	SIGNOR\|EPSD\|PSP	TAL1 BHLHA17 SCL TCL5	AARDLKGRDAATAEARHRVPtTELCRPPGPAPAPAPASVTA
P17655	T464	Sugiyama	CAPN2 CANPL2	TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P18031	S50	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	FPCRVAKLPKNKNRNRyRDVsPFDHSRIKLHQEDNDyINAs
P18583	S2011	Sugiyama	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	RSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P19174	S1248	EPSD\|PSP	PLCG1 PLC1	LRERGsDASGQLFHGRAREGsFEsRyQQPFEDFRIsQEHLA
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	T641	PSP	NCL	EDAKAAKEAMEDGEIDGNKVtLDWAKPKGEGGFGGRGGGRG
P19338	T707	PSP	NCL	RGGFRGGRGGGGDHKPQGKKtKFE_________________
P19484	S467	EPSD\|PSP	TFEB BHLHE35	SDPLLstMsPEAsKAssRRssFsMEEGDVL___________
P19634	S648	GPS6\|EPSD\|PSP	SLC9A1 APNH1 NHE1	EEEIRKILRNNLQKTRQRLRsyNRHtLVADPyEEAWNQMLL
P19634	S703	GPS6\|EPSD\|PSP	SLC9A1 APNH1 NHE1	yLtVPAHKLDsPtMsRARIGsDPLAyEPKEDLPVItIDPAs
P19634	S796	GPS6\|EPSD\|PSP	SLC9A1 APNH1 NHE1	DVFtPAPsDsPssQRIQRCLsDPGPHPEPGEGEPFFPKGQ_
P20618	S162	Sugiyama	PSMB1 PSC5	DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20749	S41	SIGNOR\|EPSD\|PSP	BCL3 BCL4 D19S37	KAAGLPGAALPLRKRPLRAPsPEPAAPRGAAGLVVPLDPLR
P21333	S2152	EPSD\|PSP	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21453	T236	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	S1PR1 CHEDG1 EDG1	SIVILYCRIYSLVRTRSRRLtFRKNISKASRSSEKSLALLK
P22087	S124	Sugiyama	FBL FIB1 FLRN	DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P22736	S351	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NR4A1 GFRP1 HMR NAK1	GMVKEVVRTDsLKGRRGRLPsKPKQPPDAsPANLLtSLVRA
P23396	T70	SIGNOR\|EPSD\|PSP	RPS3 OK/SW-cl.26	ILATRTQNVLGEKGRRIRELtAVVQKRFGFPEGsVELyAEK
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S422	SIGNOR	EIF4B	ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs
P23769	S401	SIGNOR\|iPTMNet\|EPSD\|PSP	GATA2	NVNRPLTMKKEGIQTRNRKMsNKSKKSKKGAECFEELSKCM
P24941	T39	SIGNOR\|EPSD\|PSP	CDK2 CDKN2	yKARNKLTGEVVALKKIRLDtETEGVPstAIREIsLLKELN
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054	S1861	Sugiyama	APC DP2.5	DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P25205	S447	Sugiyama	MCM3	EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705	S76	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P26358	S143	SIGNOR\|EPSD\|PSP	DNMT1 AIM CXXC9 DNMT	ADANsPPKPLSKPRTPRRsKsDGEAKPEPsPsPRITRKSTR
P26373	S106	PSP	RPL13 BBC1 OK/SW-cl.46	IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26678	T17	SIGNOR	PLN PLB	____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFCL
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29317	S897	EPSD\|PSP	EPHA2 ECK	APDSLKTLADFDPRVsIRLPstsGsEGVPFRTVsEWLESIK
P29375	S1255	SIGNOR\|EPSD\|PSP	KDM5A JARID1A RBBP2 RBP2	KLPVRLPEGEALQCLTERAMsWQDRARQALATDELSSALAK
P29375	S225	SIGNOR\|EPSD\|PSP	KDM5A JARID1A RBBP2 RBP2	PEPGtRMNILPKRTRRVKTQsESGDVSRNTELKKLQIFGAG
P29375	S287	SIGNOR\|EPSD\|PSP	KDM5A JARID1A RBBP2 RBP2	KVTNRSDAFNMQMRQRKGtLsVNFVDLYVCMFCGRGNNEDK
P29375	T1225	SIGNOR\|EPSD\|PSP	KDM5A JARID1A RBBP2 RBP2	AKEVKFLCPLCMRSRRPRLEtILSLLVSLQKLPVRLPEGEA
P29375	T285	SIGNOR\|EPSD\|PSP	KDM5A JARID1A RBBP2 RBP2	RRKVTNRSDAFNMQMRQRKGtLsVNFVDLYVCMFCGRGNNE
P29401	S305	Sugiyama	TKT	LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29401	S387	EPSD\|PSP	TKT	QNMVSIAVGCATRNRtVPFCsTFAAFFTRAFDQIRMAAISE
P29401	T382	SIGNOR\|EPSD\|PSP	TKT	CYIAEQNMVSIAVGCATRNRtVPFCsTFAAFFTRAFDQIRM
P29474	S1177	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NOS3	EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474	S1179	ELM	NOS3	IFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPGSD
P29474	S615	SIGNOR\|ELM\|EPSD\|PSP	NOS3	GPYNSsPRPEQHKSYKIRFNsISCSDPLVssWRRKRKEssN
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30291	S642	EPSD\|PSP	WEE1	STTQSNRTSRLIGKKMNRSVsLTIY________________
P31323	S114	ELM	PRKAR2B	APADAGAFNAPVINRFTRRAsVCAEAyNPDEEEDDAESRII
P31749	S124	Sugiyama	AKT1 PKB RAC	QTVADGLKKQEEEEMDFRsGsPsDNsGAEEMEVsLAKPKHR
P31749	S126	Sugiyama	AKT1 PKB RAC	VADGLKKQEEEEMDFRsGsPsDNsGAEEMEVsLAKPKHRVt
P31749	S129	Sugiyama	AKT1 PKB RAC	GLKKQEEEEMDFRsGsPsDNsGAEEMEVsLAKPKHRVtMNE
P31749	S137	Sugiyama	AKT1 PKB RAC	EMDFRsGsPsDNsGAEEMEVsLAKPKHRVtMNEFEYLKLLG
P31749	S246	SIGNOR\|EPSD\|PSP	AKT1 PKB RAC	VMEYANGGELFFHLSRERVFsEDRARFYGAEIVSALDYLHS
P31749	T146	Sugiyama	AKT1 PKB RAC	sDNsGAEEMEVsLAKPKHRVtMNEFEYLKLLGKGTFGKVIL
P31749	T195	Sugiyama	AKT1 PKB RAC	YyAMKILKKEVIVAKDEVAHtLtENRVLQNSRHPFLTALKY
P31749	T197	Sugiyama	AKT1 PKB RAC	AMKILKKEVIVAKDEVAHtLtENRVLQNSRHPFLTALKYSF
P31749	T305	Sugiyama	AKT1 PKB RAC	DGHIKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDND
P31749	T308	Sugiyama	AKT1 PKB RAC	IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31749	T312	Sugiyama	AKT1 PKB RAC	DFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31749	T72	SIGNOR\|EPSD\|PSP	AKT1 PKB RAC	LNNFSVAQCQLMKTERPRPNtFIIRCLQWTTVIERTFHVEt
P31749	Y315	Sugiyama	AKT1 PKB RAC	LCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGRAVDWWGL
P31751	T309	Sugiyama	AKT2	IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31751	T313	Sugiyama	AKT2	DFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31751	Y316	Sugiyama	AKT2	LCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGRAVDWWGL
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P33778	S37	EPSD	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35222	S552	SIGNOR\|EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35226	S316	SIGNOR\|EPSD\|PSP	BMI1 PCGF4 RNF51	TSNSPSGNHQSSFANRPRKSsVNGSSATSSG__________
P35227	T334	PSP	PCGF2 MEL18 RNF110 ZNF144	NGGSLNCLQTPSSTSRGRKMtVNGAPVPPLt__________
P35232	T258	EPSD\|PSP	PHB1 PHB	LRKLEAAEDIAyQLSRSRNItyLPAGQSVLLQLPQ______
P35240	S10	EPSD\|PSP	NF2 SCH	___________MAGAIASRMsFssLKRKQPKTFTVRIVTMD
P35240	S315	EPSD\|PSP	NF2 SCH	LILQLCIGNHDLFMRRRKADsLEVQQMKAQAREEKARKQME
P35240	S518	PSP	NF2 SCH	FNLIGDSLSFDFKDTDMKRLsMEIEKEKVEYMEKSKHLQEQ
P35240	T230	EPSD\|PSP	NF2 SCH	IAQDLEMYGVNYFAIRNKKGtELLLGVDALGLHIYDPENRL
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269	T156	Sugiyama	GTF2F1 RAP74	EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35558	S90	PSP	PCK1 PEPCK1	KKYDNCWLALTDPRDVARIEsKtVIVTQEQRDTVPIPKTGL
P35568	S629	EPSD\|PSP	IRS1	DDGyMPMsPGVAPVPSGRKGsGDyMPMsPKsVSAPQQIINP
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36776	S173	SIGNOR\|PSP	LONP1 PRSS15	LRRKVRLAQPYVGVFLKRDDsNEsDVVEsLDEIYHtGtFAQ
P36776	S181	SIGNOR\|PSP	LONP1 PRSS15	QPYVGVFLKRDDsNEsDVVEsLDEIYHtGtFAQIHEMQDLG
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38398	S694	GPS6\|SIGNOR\|EPSD\|PSP	BRCA1 RNF53	PATGAKKSNKPNEQTSKRHDsDTFPELKLTNAPGsFtKCSN
P38398	T509	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	BRCA1 RNF53	EPQIIQERPLTNKLKRKRRPtsGLHPEDFIKKADLAVQKTP
P38606	S384	Sugiyama	ATP6V1A ATP6A1 ATP6V1A1 VPP2	RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38936	S146	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P38936	T145	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	EQAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40926	T179	Sugiyama	MDH2	GVYNPNKIFGVTTLDIVRANtFVAELKGLDPARVNVPVIGG
P41002	S577	SIGNOR\|EPSD\|PSP	CCNF FBX1 FBXO1	EIHAFLSSPSGRRTKRKRENsLQEDRGSFVTtPtAELSSQE
P41002	T31	SIGNOR\|EPSD\|PSP	CCNF FBX1 FBXO1	CAKCFCYPTKRRIRRRPRNLtILSLPEDVLFHILKWLSVED
P41219	S59	SIGNOR	PRPH NEF4 PRPH1	RFSSSRLLGsAsPsssVRLGsFRSPRAGAGALLRLPSERLD
P41279	S400	SIGNOR\|ELM\|EPSD\|PSP	MAP3K8 COT ESTF	ADLLKHEALNPPREDQPRCQsLDSALLERKRLLsRKELELP
P41279	S413	SIGNOR	MAP3K8 COT ESTF	EDQPRCQsLDSALLERKRLLsRKELELPENIADSSCTGSTE
P42345	S2448	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH
P42345	T2446	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1	LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42858	S419	SIGNOR\|EPSD\|PSP	HTT HD IT15	GGIGQLtAAKEEsGGRsRsGsIVELIAGGGssCsPVLsRKQ
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45880	S48	PSP	VDAC2	IFNKGFGFGLVKLDVKTKsCsGVEFSTSGSSNTDTGKVtGt
P45974	S783	Sugiyama	USP5 ISOT	IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P45985	S80	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	tLNPNPtGVQNPHIERLRTHsIEsSGKLKIsPEQHWDFtAE
P46527	S10	GPS6\|ELM\|EPSD\|PSP	CDKN1B KIP1 p27	___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P46527	T157	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDKN1B KIP1 p27	PsDsQTGLAEQCAGIRKRPAtDDSSTQNKRANRTEENVsDG
P46527	T187	GPS6\|EPSD	CDKN1B KIP1 p27	ANRTEENVsDGsPNAGSVEQtPKKPGLRRRQt_________
P46527	T198	GPS6\|SIGNOR\|EPSD\|PSP	CDKN1B KIP1 p27	sPNAGSVEQtPKKPGLRRRQt____________________
P46937	S127	SIGNOR\|ELM\|EPSD\|PSP	YAP1 YAP65	QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47870	S472	SIGNOR	GABRB2	GRNALERHVAQKKSRLRRRAsQLKITIPDLTDVNAIDRWSR
P48431	T116	SIGNOR\|PSP	SOX2	RLRALHMKEHPDYKYRPRRKtKTLMKKDKYTLPGGLLAPGG
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49753	T118	Sugiyama	ACOT2 PTE2 PTE2A	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
P49760	S34	GPS6\|SIGNOR\|EPSD\|PSP	CLK2	SRGSYREHYRSRKHKRRRSRsWSSSSDRTRRRRREDsYHVR
P49760	T127	GPS6\|SIGNOR\|EPSD\|PSP	CLK2	SYRSQRSSRRKHRRRRRRSRtFSRSSSQHSSRRAKsVEDDA
P49790	S1461	Sugiyama	NUP153	SPAAFTVGSNGKNVFsssGtsFsGRKIKTAVRRRK______
P49815	S939	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TSC2 TSC4	NVLLsFDDtPEKDsFRARsTsLNERPKSLRIARPPKQGLNN
P49815	S981	EPSD\|PSP	TSC2 TSC4	PPVKEFKESSAAEAFRCRsIsVsEHVVRSRIQTSLTsAsLG
P49815	T1462	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TSC2 TSC4	EGPLPsssPRsPsGLRPRGYtIsDsAPsRRGKRVERDALKS
P49840	S21	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	GSK3A	MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841	S9	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49918	S282	SIGNOR\|EPSD\|PSP	CDKN1C KIP2	AAIKKLSGPLISDFFAKRKRsAPEKssGDVPAPCPsPsAAP
P49918	T310	SIGNOR\|EPSD\|PSP	CDKN1C KIP2	DVPAPCPsPsAAPGVGSVEQtPRKRLR______________
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51617	T100	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	IRAK1 IRAK	VADLVHILTHLQLLRARDIItAWHPPAPLPSPGTTAPRPSS
P51812	S19	SIGNOR\|PSP	RPS6KA3 ISPK1 MAPKAPK1B RSK2	__MPLAQLADPWQKMAVEsPsDsAENGQQIMDEPMGEEEIN
P51946	T12	Sugiyama	CCNH	_________MYHNsSQKRHWtFSsEEQLARLRADANRKFRC
P52789	T473	SIGNOR\|PSP	HK2	AAMVTAVAYRLADQHRARQKtLEHLQLSHDQLLEVKRRMKV
P53004	S230	SIGNOR	BLVRA BLVR BVR	KsPLSWIEEKGPGLKRNRyLsFHFKsGsLENVPNVGVNKNI
P53365	S260	SIGNOR\|EPSD\|PSP\|Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396	S451	PSP	ACLY	AAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAK
P53396	S455	SIGNOR\|PSP\|Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396	T447	PSP	ACLY	QPPTAAHTANFLLNAsGststPAPsRtAsFsEsRADEVAPA
P53602	S96	SIGNOR\|PSP	MVD MPD	QPRLQACLREIRCLARKRRNsRDGDPLPsSLSCKVHVASVN
P53804	S378	SIGNOR\|EPSD\|PSP	TTC3 DCRR1 RNF105 TPRD	ANKDPIKAFYENRAYTPRsLsAPIFTTSLNFVEKERDFRKI
P54253	S775	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ATXN1 ATX1 SCA1	APFLTKIEPSKPAATRKRRWsAPESRKLEKSEDEPPLTLPK
P54274	T273	GPS6\|EPSD\|PSP	TERF1 PIN2 TRBF1 TRF TRF1	STFLMKAAAKVVESKRTRtItSQDKPSGNDVEMETEANLDT
P54274	T358	PSP	TERF1 PIN2 TRBF1 TRF TRF1	KERRVGtPQSTKKKKESRRAtESRIPVSKsQPVtPEKHRAR
P54578	S432	SIGNOR\|EPSD\|PSP	USP14 TGT	SNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFDD
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55072	S352	SIGNOR\|EPSD\|PSP	VCP HEL-220 HEL-S-70	MDGLKQRAHVIVMAAtNRPNsIDPALRRFGRFDREVDIGIP
P55072	S746	SIGNOR\|EPSD\|PSP	VCP HEL-220 HEL-S-70	DPVPEIRRDHFEEAMRFARRsVsDNDIRKyEMFAQtLQQsR
P55072	S748	SIGNOR\|EPSD\|PSP	VCP HEL-220 HEL-S-70	VPEIRRDHFEEAMRFARRsVsDNDIRKyEMFAQtLQQsRGF
P55196	S216	Sugiyama	AFDN AF6 MLLT4	SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55211	S183	iPTMNet	CASP9 MCH6	CLIINNVNFCRESGLRTRTGsNIDCEKLRRRFssLHFMVEV
P55211	S196	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CASP9 MCH6	GLRTRTGsNIDCEKLRRRFssLHFMVEVKGDLTAKKMVLAL
P55265	T1033	SIGNOR\|PSP	ADAR ADAR1 DSRAD G1P1 IFI4	VESSDIVPTWDGIRLGERLRtMSCSDKILRWNVLGLQGALL
P55316	T279	EPSD\|PSP	FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C	PSSDDVFIGGTTGKLRRRSTtSRAKLAFKRGARLTSTGLTF
P56270	T385	EPSD\|PSP	MAZ ZNF801	PFKCEKCEAAFATKDRLRAHtVRHEEKVPCHVCGKMLSSAY
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57059	S435	SIGNOR	SIK1 SIK SNF1LK	WPLFFPVDASCSGVFRPRPVsPssLLDTAISEEARQGPGLE
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60484	S380	iPTMNet	PTEN MMAC1 TEP1	SSsTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQI
P60484	S385	iPTMNet	PTEN MMAC1 TEP1	VtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV__
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60983	T27	Sugiyama	GMFB	VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE
P61247	S112	PSP	RPS3A FTE1 MFTL	QGKNCLTNFHGMDLTRDKMCsMVKKWQTMIEAHVDVKTTDG
P61247	T10	PSP	RPS3A FTE1 MFTL	___________MAVGKNKRLtKGGKKGAKKKVVDPFSKKDW
P61247	T88	PSP	RPS3A FTE1 MFTL	EVSLADLQNDEVAFRKFKLItEDVQGKNCLTNFHGMDLTRD
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353	S86	Sugiyama	RPL27	SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62136	T320	EPSD\|PSP	PPP1CA PPP1A	DKNKGKyGQFSGLNPGGRPItPPRNsAKAKK__________
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280	S74	Sugiyama	RPS11	tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62424	T106	PSP	RPL7A SURF-3 SURF3	ALDRQTAtQLLKLAHKYRPEtKQEKKQRLLARAEKKAAGKG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62753	S236	PSP	RPS6 OK/SW-cl.2	RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62826	T32	Sugiyama	RAN ARA24 OK/SW-cl.81	KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63000	S71	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAC1 TC25 MIG5	VNLGLWDTAGQEDyDRLRPLsYPQTDVFLICFSLVSPASFE
P63104	S184	iPTMNet	YWHAZ	HPIRLGLALNFSVFYYEILNsPEKACSLAKtAFDEAIAELD
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	S58	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	YWHAZ	NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S209	PSP	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68400	T13	EPSD\|PSP\|Sugiyama	CSNK2A1 CK2A1	________MSGPVPSRARVytDVNTHRPREYWDYESHVVEW
P68431	T46	EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78362	T492	GPS6\|SIGNOR\|EPSD\|PSP	SRPK2	SEGSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLL
P78371	S260	SIGNOR\|EPSD\|PSP	CCT2 99D8.1 CCTB	ANtGMDtDKIKIFGsRVRVDstAKVAEIEHAEKEKMKEKVE
P78563	T553	SIGNOR\|PSP	ADARB1 ADAR2 DRADA2 RED1	VRSNASIQTWDGVLQGERLLtMSCSDKIARWNVVGIQGSLL
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P84022	T179	EPSD\|PSP	SMAD3 MADH3	SIPENTNFPAGIEPQSNIPEtPPPGYLSEDGETSDHQMNHS
P84103	S122	PSP	SRSF3 SFRS3 SRP20	DDYRRRSPPPRRRSPRRRSFsRSRSRsLsRDRRRERsLsRE
P84103	S128	PSP	SRSF3 SFRS3 SRP20	SPPPRRRSPRRRSFsRSRSRsLsRDRRRERsLsRERNHKPs
P84103	S130	PSP	SRSF3 SFRS3 SRP20	PPRRRSPRRRSFsRSRSRsLsRDRRRERsLsRERNHKPsRs
P84103	S138	PSP	SRSF3 SFRS3 SRP20	RRSFsRSRSRsLsRDRRRERsLsRERNHKPsRsFSRSRSRS
P84103	S140	PSP	SRSF3 SFRS3 SRP20	SFsRSRSRsLsRDRRRERsLsRERNHKPsRsFSRSRSRSRS
P84243	S11	SIGNOR	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	__________MARtKQTARKstGGKAPRKQLATKAARKsAP
P98170	S87	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	XIAP API3 BIRC4 IAP3	HAAVDRWQYGDSAVGRHRKVsPNCRFINGFYLENSATQSTN
P98177	S197	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO4 AFX AFX1 MLLT7	WWMLNPEGGKSGKAPRRRAAsMDSSSKLLRGRSKAPKKKPS
P98177	S262	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO4 AFX AFX1 MLLT7	PCSRNREEADMWTTFRPRSSsNAsSVsTRLSPLRPESEVLA
P98177	T32	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	FOXO4 AFX AFX1 MLLT7	AAAIIDLDPDFEPQSRPRsCtWPLPRPEIANQPSEPPEVEP
P98177	T451	ELM\|iPTMNet	FOXO4 AFX AFX1 MLLT7	LSMIAPPPVMASAPIPKALGtPVLtPPTEAASQDRMPQDLD
P98177	T455	iPTMNet	FOXO4 AFX AFX1 MLLT7	APPPVMASAPIPKALGtPVLtPPTEAASQDRMPQDLDLDMY
P99999	Y47	SIGNOR\|PSP	CYCS CYC	HKTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLME
Q00610	S147	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00613	S230	SIGNOR\|PSP	HSF1 HSTF1	PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q00613	S326	GPS6\|SIGNOR\|PSP	HSF1 HSTF1	QsPRVEEAsPGRPssVDtLLsPtALIDsILREsEPAPAsVT
Q00613	T142	SIGNOR\|PSP	HSF1 HSTF1	VSTLKSEDIKIRQDSVTKLLtDVQLMKGKQECMDSKLLAMK
Q00613	T527	SIGNOR\|PSP	HSF1 HSTF1	AEDPTISLLTGSEPPKAKDPtVS__________________
Q00987	S166	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MDM2	KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q00987	S172	iPTMNet	MDM2	LVSRPstSSRRRAIsEtEENsDELsGERQRKRHKsDsISLs
Q00987	S186	SIGNOR\|ELM\|EPSD\|PSP	MDM2	sEtEENsDELsGERQRKRHKsDsISLsFDESLALCVIREIC
Q00987	S188	SIGNOR\|ELM\|EPSD\|PSP	MDM2	tEENsDELsGERQRKRHKsDsISLsFDESLALCVIREICCE
Q00987	S192	iPTMNet	MDM2	sDELsGERQRKRHKsDsISLsFDESLALCVIREICCERSSS
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01860	T235	SIGNOR	POU5F1 OCT3 OCT4 OTF3	ENLQEICKAETLVQARKRKRtsIENRVRGNLENLFLQCPKP
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04912	S1394	SIGNOR\|ELM\|EPSD\|PSP	MST1R PTK8 RON	RPEQPQFSPMPGNVRRPRPLsEPPRPT______________
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05195	S145	SIGNOR\|EPSD\|PSP	MXD1 MAD	EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD
Q05397	S695	SIGNOR\|EPSD\|PSP	PTK2 FAK FAK1	QLsTILEEEKAQQEERMRMEsRRQAtVsWDsGGsDEAPPKP
Q05397	T700	SIGNOR\|EPSD\|PSP	PTK2 FAK FAK1	LEEEKAQQEERMRMEsRRQAtVsWDsGGsDEAPPKPsRPGY
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06187	S51	SIGNOR\|EPSD\|PSP	BTK AGMX1 ATK BPK	LLTVHKLSyyEyDFERGRRGsKKGsIDVEKITCVETVVPEK
Q06187	T495	SIGNOR\|EPSD\|PSP	BTK AGMX1 ATK BPK	EYMANGCLLNYLREMRHRFQtQQLLEMCKDVCEAMEyLESK
Q06203	T397	PSP	PPAT GPAT	SDNFKGKRIVLVDDSIVRGNtIsPIIKLLKESGAKEVHIRV
Q07352	S203	EPSD\|PSP	ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B	RALAGARDLSADRPRLQHSFsFAGFPSAAATAAATGLLDSP
Q07352	S92	SIGNOR\|ELM\|EPSD\|PSP	ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B	KGEPAPALSSRDsRFRDRsFsEGGERLLPTQKQPGGGQVNS
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07812	S184	SIGNOR\|PSP	BAX BCL2L4	YFGtPTWQtVtIFVAGVLTAsLtIWKKMG____________
Q09472	S1834	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	EP300 P300	RQQQLQHRLQQAQMLRRRMAsMQRTGVVGQQQGLPSPTPAT
Q12778	S256	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO1 FKHR FOXO1A	WWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSRAAKKKAs
Q12778	S319	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO1 FKHR FOXO1A	PGsHsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLG
Q12778	S322	ELM	FOXO1 FKHR FOXO1A	HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778	S325	ELM	FOXO1 FKHR FOXO1A	DDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHS
Q12778	T24	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FOXO1 FKHR FOXO1A	APQVVEIDPDFEPLPRPRsCtWPLPRPEFSQSNSATSSPAP
Q12906	S647	SIGNOR\|EPSD\|PSP	ILF3 DRBF MPHOSPH4 NF90	GPMHNEVPPPPNLRGRGRGGsIRGRGRGRGFGGANHGGYMN
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q12982	S114	Sugiyama	BNIP2 NIP2	EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13009	S231	EPSD\|PSP	TIAM1	ARGMETRASPRQLsTCQRANsLGDLyAQKNSGVTANGGPGS
Q13043	T120	GPS6\|SIGNOR\|EPSD\|PSP	STK4 KRS2 MST1	IVMEYCGAGSVSDIIRLRNKtLtEDEIAtILQStLKGLEYL
Q13043	T183	PSP	STK4 KRS2 MST1	AKLADFGVAGQLtDtMAKRNtVIGtPFWMAPEVIQEIGYNC
Q13043	T387	GPS6\|SIGNOR\|EPSD\|PSP	STK4 KRS2 MST1	tMVINAEDEEEEGtMKRRDEtMQPAKPsFLEyFEQKEKENQ
Q13045	S436	PSP	FLII FLIL	AGsGPKDPMARKMRLRRRKDsAQDDQAKQVLKGMSDVAQEK
Q13107	S445	SIGNOR\|EPSD\|PSP	USP4 UNP UNPH	GRPDAVVAKEAWENHRLRNDsVIVDTFHGLFKSTLVCPECA
Q13131	S494	PSP	PRKAA1 AMPK1	FRsIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDAEAQG
Q13131	S496	SIGNOR\|EPSD\|PSP	PRKAA1 AMPK1	sIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDAEAQGKs
Q13185	T55	PSP	CBX3	VLDRRVVNGKVEYFLKWKGFtDADNTWEPEENLDCPELIEA
Q13185	T89	PSP	CBX3	CPELIEAFLNSQKAGKEKDGtKRKsLsDsEsDDsKSKKKRD
Q13188	T117	GPS6\|SIGNOR\|EPSD\|PSP	STK3 KRS1 MST2	IVMEYCGAGSVSDIIRLRNKtLIEDEIATILKSTLKGLEYL
Q13188	T384	GPS6\|SIGNOR\|EPSD\|PSP	STK3 KRS1 MST2	TMVINSEDEEEEDGtMKRNAtsPQVQRPsFMDyFDKQDFKN
Q13247	S297	Sugiyama	SRSF6 SFRS6 SRP55	RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13283	S250	Sugiyama	G3BP1 G3BP	sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13309	S72	PSP	SKP2 FBXL1	PQELLsNLGHPEsPPRKRLKsKGsDKDFVIVRRPKLNRENF
Q13370	S295	SIGNOR\|iPTMNet	PDE3B	HPRLssAAEEKVPVIRPRRRssCVsLGETAASYYGSCKIFR
Q13370	S318	SIGNOR\|iPTMNet	PDE3B	VsLGETAASYYGSCKIFRRPsLPCISREQMILWDWDLKQWY
Q13370	S442	iPTMNet	PDE3B	RKLNKGLNRNSLPTPQLRRssGtsGLLPVEQSSRWDRNNGK
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13464	S479	Sugiyama	ROCK1	KLDKIMKELDEEGNQRRNLEsTVsQIEKEKMLLQHRINEYQ
Q13541	S65	iPTMNet	EIF4EBP1	ttPGGtRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPs
Q13541	T37	iPTMNet	EIF4EBP1	ATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRK
Q13541	T46	iPTMNet	EIF4EBP1	GVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNsP
Q13950	S196	EPSD\|PSP	RUNX2 AML3 CBFA1 OSF2 PEBP2A	KNQVARFNDLRFVGRSGRGKsFtLtITVFTNPPQVATYHRA
Q13950	S28	EPSD\|PSP	RUNX2 AML3 CBFA1 OSF2 PEBP2A	STVTPCQQNFFWDPSTsRRFsPPSSSLQPGKMSDVsPVVAA
Q13950	T198	EPSD\|PSP	RUNX2 AML3 CBFA1 OSF2 PEBP2A	QVARFNDLRFVGRSGRGKsFtLtITVFTNPPQVATYHRAIK
Q13950	T200	EPSD\|PSP	RUNX2 AML3 CBFA1 OSF2 PEBP2A	ARFNDLRFVGRSGRGKsFtLtITVFTNPPQVATYHRAIKVT
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14204	S4162	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL
Q14315	S2233	SIGNOR\|EPSD\|PSP	FLNC ABPL FLN2	VGGDPFPAVFGDFLGRERLGsFGsITRQQEGEAsSQDMTAQ
Q14315	S2246	GPS6	FLNC ABPL FLN2	LGRERLGsFGsITRQQEGEAsSQDMTAQVTsPSGKVEAAEI
Q14457	S234	PSP	BECN1 GT197	KVQAEAERLDQEEAQyQREysEFKRQQLELDDELKSVENQM
Q14457	S295	EPSD\|PSP	BECN1 GT197	HIWHsGQFGTINNFRLGRLPsVPVEWNEINAAWGQTVLLLH
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14676	T447	Sugiyama	MDC1 KIAA0170 NFBD1	WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR
Q14694	T674	PSP	USP10 KIAA0190	ESVQGYTTKTKQEVEISRRVtLEKLPPVLVLHLKRFVYEKT
Q14957	S1081	SIGNOR	GRIN2C NMDAR2C	ARREALLHAAWARGSRPRHAsLPSSVAEAFARPSSLPAGCT
Q14CB8	S422	EPSD\|PSP	ARHGAP19	TQtPGREPSTSQVQKRARsRsFSGLIKRKVLGNQMMsEKKK
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15027	S554	SIGNOR\|ELM\|EPSD\|PSP	ACAP1 CENTB1 KIAA0050	GRPRGQPPVPPKPSIRPRPGsLRSKPEPPSEDLGSLHPGAL
Q15118	T346	SIGNOR\|EPSD\|PSP	PDK1 PDHK1	RKIDRLFNYMYStAPRPRVEtSRAVPLAGFGYGLPISRLYA
Q15121	S116	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	PEA15	DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15633	S283	SIGNOR\|EPSD\|PSP	TARBP2 TRBP	CTWDSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSE
Q15633	S286	SIGNOR	TARBP2 TRBP	DSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSEEQA
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15672	S123	EPSD\|PSP	TWIST1 BHLHA38 TWIST	yEELQTQRVMANVRERQRtQsLNEAFAALRKIIPTLPSDKL
Q15672	S42	SIGNOR\|EPSD\|PSP	TWIST1 BHLHA38 TWIST	EEPDRQQPPSGKRGGRKRRSsRRSAGGGAGPGGAAGGGVGG
Q15672	T121	EPSD\|PSP	TWIST1 BHLHA38 TWIST	QsyEELQTQRVMANVRERQRtQsLNEAFAALRKIIPTLPSD
Q15717	S100	PSP	ELAVL1 HUR	TLNGLRLQsKTIKVSYARPssEVIKDANLyISGLPRTMtQK
Q15811	S315	Sugiyama	ITSN1 ITSN SH3D1A	LPPVLPPEYIPPSFRRVRsGsGIsVIsSTSVDQRLPEEPVL
Q15910	S21	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	EZH2 KMT6	MGQTGKKSEKGPVCWRKRVKsEYMRLRQLKRFRRADEVKSM
Q15942	S142	SIGNOR\|EPSD\|PSP	ZYX	EEEGGPEAPIPPPPQPREKVssIDLEIDsLssLLDDMTKND
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16584	S674	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP3K11 MLK3 PTK1 SPRK	sLGLGRDLQPPGGPGRERGEsPTTPPTPTPAPCPTEPPPsP
Q16584	T477	PSP	MAP3K11 MLK3 PTK1 SPRK	LTLLLQQVDRERPHVRRRRGtFKRSKLRARDGGERISMPLD
Q16637	S31	Sugiyama	SMN1 SMN SMNT; SMN2 SMNC	GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q16763	T152	SIGNOR\|EPSD\|PSP\|Sugiyama	UBE2S E2EPF OK/SW-cl.73	EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA
Q16778	S37	GPS6	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16875	S461	SIGNOR\|EPSD\|PSP	PFKFB3	THRERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEE
Q2PPJ7	S486	EPSD\|PSP	RALGAPA2 C20orf74 KIAA1272	KEASSESSGHKRSSsWGRtYsFTSAMSRGCVTEEENTNVKA
Q2PPJ7	S696	EPSD	RALGAPA2 C20orf74 KIAA1272	QRGKGCVLDPQKGTTVGRSFsLSWRsHPDVTEPMRFRSAtT
Q2PPJ7	T715	EPSD\|PSP	RALGAPA2 C20orf74 KIAA1272	FsLSWRsHPDVTEPMRFRSAtTsGAPGVEKARNIVRQKATE
Q3KQU3	S112	Sugiyama	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3V6T2	S1417	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	CCDC88A APE GRDN KIAA1212	TLKMRKLIKSKKDINRERQKsLtLtPtRsDssEGFLQLPHQ
Q53EL6	S457	SIGNOR\|ELM\|EPSD\|PSP	PDCD4 H731	GIISKQLRDLCPSRGRKRFVsEGDGGRLKPESY________
Q53EL6	S67	SIGNOR\|ELM\|EPSD\|PSP	PDCD4 H731	AssINEARINAKAKRRLRKNssRDsGRGDsVsDsGsDALRS
Q53EL6	S76	Sugiyama	PDCD4 H731	NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5SW79	S881	Sugiyama	CEP170 FAM68A KAB KIAA0470	sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5TA89	S34	PSP	HES5 BHLHB38	KEKNRLRKPVVEKMRRDRINssIEQLKLLLEQEFARHQPNS
Q5TA89	S35	PSP	HES5 BHLHB38	EKNRLRKPVVEKMRRDRINssIEQLKLLLEQEFARHQPNSK
Q5UE93	T607	SIGNOR\|PSP	PIK3R6 C17orf38	GAELSLCYQKALLSHRPREVtVSLRATGLILKAIPASDTEV
Q5VTB9	T368	Sugiyama	RNF220 C1orf164	ENNNRFEEYEWCGQKRIRATtLLEGGFRGSGFIMCSGKENP
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5VWQ8	S971	SIGNOR	DAB2IP AF9Q34 AIP1 KIAA1743	GtLASAsPDWVGPSTRLRQQssSsKGDsPELKPRAVHKQGP
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q5XUX0	S33	SIGNOR\|EPSD\|PSP	FBXO31 FBX14 FBX31 PP2386	SRGCRRRQQRRGPAETAAADsEPDtDPEEERIEASAGVGGG
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6PIY7	S110	PSP	TENT2 GLD2 PAPD4	RQRFHsPHQEPtVVNQIVPLsGERRYsMPPLFHTHYVPDIV
Q6PIY7	S116	GPS6\|SIGNOR\|PSP	TENT2 GLD2 PAPD4	PHQEPtVVNQIVPLsGERRYsMPPLFHTHYVPDIVRCVPPF
Q6PKG0	S1056	SIGNOR	LARP1 KIAA0731 LARP	HKRHsVVAGGGGGEGRKRCPsQsssRPAAMIsQPPtPPTGQ
Q6PKG0	S847	SIGNOR	LARP1 KIAA0731 LARP	PLEsHVGWVMDSREHRPRtAsIsssPsEGtPtVGsyGCtPQ
Q6R327	T1135	EPSD\|PSP	RICTOR KIAA1999	PKGGKLSSESKTSNRRIRtLtEPsVDFNHsDDFtPISTVQK
Q6U7Q0	S224	SIGNOR\|PSP	ZNF322 ZNF322A ZNF388 ZNF489	THTGERPYKCNKCEKSYRHRsAFIVHKRVHtGEKPYKCGAC
Q6U7Q0	T150	SIGNOR\|PSP	ZNF322 ZNF322A ZNF388 ZNF489	DICGKNFGQSSDLLVHQRSHtGEKPYLCSECDKCFSRSTNL
Q6U7Q0	T234	SIGNOR\|PSP	ZNF322 ZNF322A ZNF388 ZNF489	NKCEKSYRHRsAFIVHKRVHtGEKPYKCGACEKCFGQKSDL
Q6U7Q0	T262	SIGNOR\|PSP	ZNF322 ZNF322A ZNF388 ZNF489	GACEKCFGQKSDLIVHQRVHtGEKPYKCLECMRSFTRSANL
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7L2J0	S152	Sugiyama	MEPCE BCDIN3	PRNGYQPHRPPGGGGGKRRNsCNVGGGGGGFKHPAFKRRRR
Q7L5N1	S60	SIGNOR\|EPSD\|PSP	COPS6 CSN6 HVIP	SVALHPLVILNISDHWIRMRsQEGRPVQVIGALIGKQEGRN
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z589	S209	EPSD\|PSP	EMSY C11orf30 GL002	VKSVSCsDEDEKPRKRRRtNsssssPVVLKEVPKAVVPVSK
Q7Z5H3	S16	SIGNOR\|EPSD\|PSP	ARHGAP22 RHOGAP2	_____MLSPKIRQARRARsKsLVMGEQSRSPGRMPCPHRLG
Q7Z5L9	S455	Sugiyama	IRF2BP2	AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z6J0	S125	GPS6	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	ANCSSKDLQSSQGGQQPRVQsWsPPVRGIPQLPCAKALYNY
Q7Z6J0	S304	GPS6\|SIGNOR\|EPSD\|PSP	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	AQSSTAPKHSDTKKNTKKRHsFTSLTMANKssQAsQNRHsM
Q7Z6J0	S800	GPS6	SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2	PVTTAVAGAALAQDAFHRKAssLDSAVPIAPPPRQACSSLG
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86T24	T606	PSP	ZBTB33 KAISO ZNF348	LHPCRSLQIRQYAYLSDRSStIPAMKDDGIGYKVDTGKEPP
Q86TI0	T596	EPSD\|PSP	TBC1D1 KIAA1108	HLPEEPAPLsPQQAFRRRANtLsHFPIECQEPPQPARGsPG
Q86TX2	T56	Sugiyama	ACOT1 CTE1	ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
Q86V81	S34	EPSD\|PSP	ALYREF ALY BEF THOC4	KLNRSQRGGRGGGRGRGRAGsQGGRGGGAQAAARVNRGGGP
Q86V81	T219	SIGNOR\|EPSD\|PSP	ALYREF ALY BEF THOC4	GMTRNRGAGGFGGGGGTRRGtRGGARGRGRGAGRNSKQQLs
Q86VP3	S437	EPSD\|PSP	PACS2 KIAA0602 PACS1L	LVIPSTRSEGKQAGRRGRSTsLKERQAARPQNERANsLDNE
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86VY4	T120	PSP	TSPYL5 KIAA1750	AAARPGPGKAASLSERLAADtVFVGTAGTVGRPKNAPRVGN
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8	S904	Sugiyama	CHERP DAN26 SCAF6	KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IYJ3	S241	SIGNOR\|EPSD\|PSP	SYTL1 SLP1 SB146	NGEEAPGPDPSLDRMLsssssVssLNSSTLSGSQMSLSGDA
Q8N3D4	S1257	Sugiyama	EHBP1L1	EGLVNGAGAPGGGGVRLRRPsVNGEPGSVPPPRAHGsFsHV
Q8N5V2	S16	PSP	NGEF	_____METRESEDLEKTRRKsAsDQWNTDNEPAKVKPELLP
Q8N5V2	S18	PSP	NGEF	___METRESEDLEKTRRKsAsDQWNTDNEPAKVKPELLPEK
Q8N6T7	S338	EPSD\|PSP	SIRT6 SIR2L6	EPCAQHNGsEPAsPKRERPtsPAPHRPPKRVKAKAVPS___
Q8N9L9	S392	SIGNOR\|PSP	ACOT4 PTE2B PTEIB	ASLHRLLNKHVIWGGEPRAHsKAQEDAWKQILAFFCKHLGG
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBP7	S488	Sugiyama	PCSK9 NARC1 PSEC0052	TRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKLV
Q8NCD3	S486	GPS6\|SIGNOR\|EPSD\|PSP	HJURP FAKTS FLEG1 URLC9	MYRGGPAsPGGLQGLETRRLsLPSSKAKAKsLSEAFENLGK
Q8TCD5	S182	Sugiyama	NT5C DNT1 UMPH2	LFTCCHNRHLVLPPTRRRLLsWsDNWREILDSKRGAAQRE_
Q8TD19	T333	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TDN4	T309	SIGNOR\|PSP	CABLES1 CABLES	RssLEtLEDIEENAPLRRCRtLSGsPRPKNFKKIHFIKNMR
Q8TDN4	T415	SIGNOR\|PSP	CABLES1 CABLES	KTVSYTQFLLPTNAFGARRNtIDstssFSQFRNLSHRSLSI
Q8TEW0	S837	Sugiyama	PARD3 PAR3 PAR3A	AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI
Q8WTX7	S14	PSP	CASTOR1 GATSL3	_______MELHILEHRVRVLsVARPGLWLYTHPLIKLLFLP
Q8WWL2	S476	Sugiyama	SPIRE2 KIAA1832 SPIR2	GLQSATHPPGGTEPPRPRAGsAHVWRPGSRDQGTCPASVSD
Q8WX93	S1118	GPS6\|SIGNOR\|EPSD\|PSP	PALLD KIAA0992 CGI-151	RGRsPRsPsGHPHVRRPRsRsRDsGDENEPIQERFFRPHFL
Q8WYL5	T826	EPSD\|PSP	SSH1 KIAA1298 SSH1L	LMQHQEsIIQLQKAGLVRKHtKELERLKsVPADPAPPSRDG
Q92547	S1159	EPSD\|PSP	TOPBP1 KIAA0259	QNEQIIWDDPTAREERARLAsNLQWPSCPTQYSELQVDIQN
Q92597	S330	Sugiyama	NDRG1 CAP43 DRG1 RTP	QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92793	T1871	EPSD\|PSP	CREBBP CBP	RQQQIQHRLQQAQLMRRRMAtMNTRNVPQQSLPSPTSAPPG
Q92794	T369	EPSD\|PSP	KAT6A MOZ MYST3 RUNXBP2 ZNF220	SKGPFSKVRTGPGRGRKRKItLSSQSASSSSEEGYLERIDG
Q92879	S28	SIGNOR\|EPSD\|PSP	CELF1 BRUNOL2 CUGBP CUGBP1 NAB50	PDQPDLDAIKMFVGQVPRtWsEKDLRELFEQYGAVYEINVL
Q92900	T151	SIGNOR\|PSP	UPF1 KIAA0221 RENT1	PACVVYCNTSKKWFCNGRGNtSGSHIVNHLVRAKCKEVTLH
Q92934	S118	SIGNOR\|iPTMNet	BAD BBC6 BCL2L8	RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934	S75	SIGNOR\|iPTMNet\|EPSD	BAD BBC6 BCL2L8	PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934	S99	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BAD BBC6 BCL2L8	GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q92945	S193	SIGNOR\|EPSD\|PSP\|Sugiyama	KHSRP FUBP2	DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q969H0	S227	SIGNOR\|PSP	FBXW7 FBW7 FBX30 SEL10	TTFGDLRAANGQGQQRRRITsVQPPTGLQEWLKMFQSWSGP
Q96B36	T246	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	AKT1S1 PRAS40	VLREAEDtQVFGDLPRPRLNtsDFQKLKRKY__________
Q96BF3	S220	SIGNOR\|EPSD\|PSP	TMIGD2 CD28H IGPR1 UNQ3059/PRO9879	RGAPKKSEDCSGEGKDQRGQsIySTSFPQPAPRQPHLAsRP
Q96CG3	T9	SIGNOR\|EPSD\|PSP	TIFA T2BP	____________MtSFEDADtEEtVTCLQMtVYHPGQLQCG
Q96F86	S161	SIGNOR\|EPSD\|PSP	EDC3 LSM16 YJDC YJEFN2 PP844	YVDRHMEsLsQsKSFRRRHNsWssSSRHPNQAtPKKSGLKN
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96GD4	T73	PSP	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	PGQKVMENssGtPDILTRHFtIDDFEIGRPLGKGKFGNVyL
Q96GX5	T299	SIGNOR\|PSP	MASTL GW GWL THC2	PGMPVKCLTSNLLQsRKRLAtSSASSQSHtFIssVEsECHs
Q96HP0	S1194	SIGNOR\|EPSD\|PSP	DOCK6 KIAA1395	DTLPRLHDFAEGPGQRSRLAsMLDsDtEGEGDIAGTINPSV
Q96J02	S257	SIGNOR\|PSP	ITCH	GNNsPsLSNGGFKPSRPPRPsRPPPPtPRRPASVNGsPSAT
Q96KG9	T469	SIGNOR\|PSP	SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019	TVCLGKIGSYLsAsTRHRVLtSAFSRATRDPFAPSRVAGVL
Q96P20	S5	GPS6\|PSP	NLRP3 C1orf7 CIAS1 NALP3 PYPAF1	________________MKMAsTRCKLARyLEDLEDVDLKKF
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96QB1	S1004	EPSD\|PSP	DLC1 ARHGAP7 KIAA1723 STARD12	RDsGVGAsLTRSNRHRLRWHsFQSSHRPSLNSVSLQINCQS
Q96QB1	S735	EPSD\|PSP	DLC1 ARHGAP7 KIAA1723 STARD12	EISALNGNRINVPMVRKRSVsNStQTSSSSsQSETSSAVST
Q96QB1	S766	SIGNOR\|EPSD\|PSP	DLC1 ARHGAP7 KIAA1723 STARD12	QSETSSAVSTPSPVTRTRsLsACNKRVGMYLEGFDPFNQST
Q96QF0	S165	SIGNOR	RAB3IP RABIN8	DGSDDIFGLsTDSLSRLRsPsVLEVREKGYERLKEELAKAQ
Q96S44	S250	SIGNOR\|EPSD\|PSP	TP53RK C20orf64 PRPK	KKARPVLKKLDEVRLRGRKRsMVG_________________
Q96ST2	S720	PSP	IWS1 IWS1L	TREEREQRDLEQMPQRRRMNstGGQtPRRDLEKVLTGEEKA
Q96ST2	T721	PSP	IWS1 IWS1L	REEREQRDLEQMPQRRRMNstGGQtPRRDLEKVLTGEEKAL
Q96T58	S1268	Sugiyama	SPEN KIAA0929 MINT SHARP	SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP
Q99418	T276	EPSD\|PSP	CYTH2 ARNO PSCD2 PSCD2L	TFFNPDREGWLLKLGGGRVKtWKRRWFILTDNCLYYFEYTT
Q99490	S985	SIGNOR	AGAP2 CENTG1 KIAA0167	ICIECSGIHRNLGTHLSRVRsLDLDDWPRELTLVLTAIGND
Q99497	T125	SIGNOR\|PSP	PARK7	ICAGPTALLAHEIGFGSKVTtHPLAKDKMMNGGHytysENR
Q99502	S299	EPSD\|PSP	EYA1	TIHSPSTPIKDSDSDRLRRGsDGKSRGRGRRNNNPsPPPDS
Q99623	S176	PSP	PHB2 BAP REA	QRAQVsLLIRRELTERAKDFsLILDDVAITELSFSREYTAA
Q99623	S91	PSP	PHB2 BAP REA	RIPWFQYPIIYDIRARPRKIssPTGSKDLQMVNISLRVLSR
Q99683	S83	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	PGIGCPAATSSSSATRGRGSsVGGGSRRTTVAYVINEASQG
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BPZ7	T86	SIGNOR\|EPSD\|PSP	MAPKAP1 MIP1 SIN1	YAQSVDITSSWDFGIRRRSNtAQRLERLRKERQNQIKCKNI
Q9BRQ0	S48	EPSD\|PSP	PYGO2 PP7910	GRKQGKAGLQMKsPEKKRRKsNtQGPAYsHLTEFAPPPTPM
Q9BRS8	S451	SIGNOR\|EPSD\|PSP	LARP6	PWVRRRRQAEMGtQEKsPGtsPLLSRKMQTADGLPVGVLRL
Q9BTC0	S1456	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BVI0	S265	EPSD\|PSP	PHF20 C20orf104 GLEA2 HCA58 NZF TZP	IVKsPQENLREPKRKRGRPPsIAPTAVDSNSQTLQPITLEL
Q9BVI0	S291	SIGNOR\|EPSD\|PSP	PHF20 C20orf104 GLEA2 HCA58 NZF TZP	VDSNSQTLQPITLELRRRKIsKGCEVPLKRPRLDKNSSQEK
Q9BW19	T159	Sugiyama	KIFC1 HSET KNSL2	LKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQVK
Q9BWT1	T163	SIGNOR\|EPSD\|PSP	CDCA7 JPO1	FRGRHPLPGSDSQSRRPRRRtFPGVASRRNPERRARPLTRS
Q9BX95	T114	Sugiyama	SGPP1 SPP1	AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BXL7	S558	SIGNOR\|PSP	CARD11 CARMA1	SCGSLPITNSFTKMQPPRsRssIMsITAEPPGNDsIVRRYK
Q9BXL7	S644	SIGNOR\|PSP	CARD11 CARMA1	QSEGLDAYDLEQVNLMFRKFsLERPFRPsVtsVGHVRGPGP
Q9BXL7	S652	SIGNOR\|PSP	CARD11 CARMA1	DLEQVNLMFRKFsLERPFRPsVtsVGHVRGPGPSVQHTTLN
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BZ23	S169	PSP	PANK2 C20orf48	EQAAGDPEGRRQEPLRRRAssAsVPAVGASAEGTRRDRLGs
Q9BZ23	S189	PSP\|Sugiyama	PANK2 C20orf48	sAsVPAVGASAEGTRRDRLGsysGPTSVSRQRVESLRKKRP
Q9BZQ8	S602	SIGNOR\|EPSD\|PSP	NIBAN1 C1orf24 FAM129A NIBAN GIG39	sLtDLKPPtGsNQAsPARRAsAILPGVLGsEtLsNEVFQEs
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H0B6	S428	Sugiyama	KLC2	NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H3H1	S431	Sugiyama	TRIT1 IPT MOD5	AAHIKSKSHLNQLKKRRRLDsDAVNTIEsQsVsPDHNKEPK
Q9H4A3	T60	SIGNOR\|ELM\|EPSD\|PSP	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GAAAADAVtGRtEEyRRRRHtMDKDSRGAAAtTtTTEHRFF
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H6Z4	S126	SIGNOR\|EPSD\|PSP	RANBP3	EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP
Q9H6Z4	S57	SIGNOR	RANBP3	SGEEPRGEAEAPHHGTGHPEsAGEHALEPPAPAGASASTPP
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H9Q4	T181	SIGNOR\|EPSD\|PSP	NHEJ1 XLF	DLEIQDYQESGATLIRDRLKtEPFEENSFLEQFMIEKLPEA
Q9HAU0	S410	Sugiyama	PLEKHA5 KIAA1686 PEPP2	NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HBH7	S102	SIGNOR	BEX1	MERIGEEVRQLMEKLREKQLsHSLRAVSTDPPHHDHHDEFC
Q9NP61	S366	Sugiyama	ARFGAP3 ARFGAP1	DDsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKD
Q9NP61	S367	Sugiyama	ARFGAP3 ARFGAP1	DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NPC1	T324	SIGNOR\|PSP	LTB4R2 BLT2R BLTR2	LTRLFEGSGEARGGGRSREGtMELRTTPQLKVVGQGRGNGD
Q9NR28	S67	EPSD\|PSP	DIABLO SMAC	TIGFGVTLCAVPIAQKSEPHsLSSEALMRRAVSLVTDSTST
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NVE7	T406	PSP	PANK4	ssGLMsAsPELGPAQRARsGtFDLLEMDRLERPLVDLPLLL
Q9NWV8	S29	EPSD\|PSP	BABAM1 C19orf62 MERIT40 NBA1 HSPC142	PtEEEEEEEEHsAEPRPRtRsNPEGAEDRAVGAQAsVGsRs
Q9NZN5	S1288	Sugiyama	ARHGEF12 KIAA0382 LARG	GLTEKsVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHs
Q9NZQ3	S256	Sugiyama	NCKIPSD AF3P21 SPIN90	GSSCSPtPPPVPRRGtHTTVsQVQPPPSKASAPEPPAEEEV
Q9P0N9	S124	SIGNOR\|PSP	TBC1D7 TBC7 HSPC239	QAEVYLRMYQLESGKLPRSPsFPLEPDDEVFLAIAKAMEEM
Q9P0V3	S246	PSP	SH3BP4 BOG25 EHB10 TTP	LHAEPPVRRDNPFFRsKRsYsLsELsVLQAKSDAPtSssFF
Q9P2H5	S613	PSP	USP35 KIAA1372 USP34	FTDLSLAFPPPERCRRRRLGsVMRPTEDITARELPPPTSAQ
Q9UBK2	S571	SIGNOR	PPARGC1A LEM6 PGC1 PGC1A PPARGC1	VSPPKSLFSQRPQRMRSRSRsFSRHRSCSRSPYSRSRSRSP
Q9UBP6	S27	SIGNOR\|iPTMNet\|EPSD\|PSP\|Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGI0	S78	SIGNOR\|EPSD\|PSP	ZRANB1 TRABID	TEGGSSPLICPDSSARPRVKsSYSMENANKWSCHMCTYLNW
Q9UGI0	T117	SIGNOR\|EPSD\|PSP	ZRANB1 TRABID	NWPRAIRCTQCLSQRRTRsPtESPQssGSGSRPVAFSVDPC
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2	T329	Sugiyama	NDRG3	FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UH77	S433	SIGNOR	KLHL3 KIAA1129	AYSYKTNEWFFVAPMNTRRSsVGVGVVEGKLYAVGGYDGAS
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKJ3	S890	Sugiyama	GPATCH8 GPATC8 KIAA0553	YSSSSDASSDQSCYSRQRSYsDDSYSDYSDRSRRHSKRSHD
Q9UKV3	S1180	GPS6\|EPSD\|PSP	ACIN1 ACINUS KIAA0670	RsEREWDRDKVREGPRSRSRsRDRRRKERAKSKEKKSEKKE
Q9ULL1	S611	Sugiyama	PLEKHG1 KIAA1209	GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UN36	S332	EPSD\|PSP\|Sugiyama	NDRG2 KIAA1248 SYLD	QGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLsQs
Q9UN36	T348	GPS6\|EPSD\|PSP	NDRG2 KIAA1248 SYLD	sRtAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHTME
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UNN5	S582	EPSD\|PSP	FAF1 UBXD12 UBXN3A CGI-03	PPEPKEENAEPVSKLRIRtPsGEFLERRFLASNKLQIVFDF
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UPY5	S26	EPSD\|PSP	SLC7A11	VVStISKGGyLQGNVNGRLPsLGNKEPPGQEKVQLKRKVTL
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQC2	S159	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	GAB2 KIAA0571	RssPAELssssQHLLRERKSsAPSHSSQPTLFTFEPPVSNH
Q9Y243	T305	Sugiyama	AKT3 PKBG	IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR
Q9Y243	T309	Sugiyama	AKT3 PKBG	DFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGRAVDW
Q9Y243	Y312	Sugiyama	AKT3 PKBG	LCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGRAVDWWGL
Q9Y261	T156	GPS6\|SIGNOR\|EPSD\|PSP	FOXA2 HNF3B TCF3B	MYGQAGLSRARDPKTYRRSYtHAKPPYSYISLITMAIQQSP
Q9Y283	S865	EPSD\|PSP	INVS INV NPHP2	ySHLPQSTEELRSGARRLEtstLSEDFQVSKETDPAPGPLS
Q9Y283	T864	EPSD\|PSP	INVS INV NPHP2	LySHLPQSTEELRSGARRLEtstLSEDFQVSKETDPAPGPL
Q9Y283	T866	EPSD\|PSP	INVS INV NPHP2	SHLPQSTEELRSGARRLEtstLSEDFQVSKETDPAPGPLSG
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7	S307	SIGNOR\|ELM\|EPSD\|PSP	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2I7	S318	EPSD\|PSP	PIKFYVE KIAA0981 PIP5K3	KsPARNRsAsItNLsLDRsGsPMVPSYEtsVsPQANRTYVR
Q9Y2V2	S52	GPS6\|SIGNOR\|EPSD\|PSP	CARHSP1	sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3C5	T135	GPS6\|SIGNOR\|EPSD\|PSP	RNF11 CGI-123	LPCMHIYHLDCIDDWLMRSFtCPSCMEPVDAALLSSYETN_
Q9Y3M2	S20	EPSD\|PSP	CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025	_MPFFGNTFsPKKTPPRKsAsLsNLHsLDRSTREVELGLEY
Q9Y4H2	S306	GPS6	IRS2	TILEAMKALKELFEFRPRsKsQssGssATHPISVPGARRHH
Q9Y4H2	S577	GPS6	IRS2	RRVsGDAAQDLDRGLRKRtYsLtTPARQRPVPQPssAsLDE
Q9Y4P1	S34	SIGNOR\|EPSD\|PSP	ATG4B APG4B AUTL1 KIAA0943	AEFEDFPETSEPVWILGRKYsIFtEKDEILSDVASRLWFTY
Q9Y534	S58	GPS6	CSDC2 PIPPIN	GGVPPRDLPsPLPTKRTRTYsATARASAGPVFKGVCKQFSR
Q9Y580	S136	Sugiyama	RBM7	RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5S9	S168	PSP	RBM8A RBM8 HSPC114 MDS014	WCFVRGPPKGKRRGGRRRsRsPDRRRR______________
Q9Y6D5	S277	Sugiyama	ARFGEF2 ARFGEP2 BIG2	RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	1.410495e-08	7.851	1	0
Cellular Senescence	R-HSA-2559583	1.144331e-07	6.941	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.954321e-07	6.709	0	0
Axon guidance	R-HSA-422475	2.128761e-07	6.672	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.596022e-07	6.252	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.053054e-07	6.152	1	1
Chromatin organization	R-HSA-4839726	7.958259e-07	6.099	0	0
Nervous system development	R-HSA-9675108	8.518334e-07	6.070	0	0
NRAGE signals death through JNK	R-HSA-193648	8.547866e-07	6.068	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.134320e-06	5.945	1	0
Apoptotic execution phase	R-HSA-75153	1.210126e-06	5.917	0	0
Cell Cycle	R-HSA-1640170	1.949287e-06	5.710	1	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.270628e-06	5.644	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.465788e-06	5.460	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.283129e-06	5.368	0	0
Generic Transcription Pathway	R-HSA-212436	4.125867e-06	5.384	1	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.526434e-06	5.344	0	0
PKMTs methylate histone lysines	R-HSA-3214841	5.969534e-06	5.224	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.399851e-06	5.194	0	0
Meiotic synapsis	R-HSA-1221632	9.576368e-06	5.019	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.190501e-05	4.924	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.952664e-05	4.709	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.991942e-05	4.701	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.421448e-05	4.616	0	0
Gene expression (Transcription)	R-HSA-74160	2.546361e-05	4.594	1	0
Cell Cycle Checkpoints	R-HSA-69620	2.658738e-05	4.575	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.767759e-05	4.558	1	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.416742e-05	4.466	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	6.671427e-05	4.176	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.082247e-05	4.150	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.897318e-05	4.103	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	8.730244e-05	4.059	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	9.742019e-05	4.011	0	0
Meiosis	R-HSA-1500620	1.072450e-04	3.970	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.116550e-04	3.952	0	0
Activation of RAC1	R-HSA-428540	1.127118e-04	3.948	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.263756e-04	3.898	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.434065e-04	3.843	1	0
Death Receptor Signaling	R-HSA-73887	1.651006e-04	3.782	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.871094e-04	3.728	1	0
Post NMDA receptor activation events	R-HSA-438064	1.827324e-04	3.738	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.106790e-04	3.676	0	0
Diseases of programmed cell death	R-HSA-9645723	2.168377e-04	3.664	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.300229e-04	3.638	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.396323e-04	3.620	0	0
Muscle contraction	R-HSA-397014	2.577012e-04	3.589	0	0
Reproduction	R-HSA-1474165	2.655614e-04	3.576	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.143545e-04	3.503	0	0
DNA methylation	R-HSA-5334118	3.410442e-04	3.467	0	0
PRC2 methylates histones and DNA	R-HSA-212300	3.565114e-04	3.448	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.526038e-04	3.453	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.469699e-04	3.460	0	0
Rap1 signalling	R-HSA-392517	3.428025e-04	3.465	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.391582e-04	3.470	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.805891e-04	3.420	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.755583e-04	3.425	1	0
HATs acetylate histones	R-HSA-3214847	3.887302e-04	3.410	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.492372e-04	3.348	0	0
Intracellular signaling by second messengers	R-HSA-9006925	4.555940e-04	3.341	1	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.593467e-04	3.338	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.797337e-04	3.319	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.321544e-04	3.274	0	0
DNA Double Strand Break Response	R-HSA-5693606	5.520155e-04	3.258	0	0
Packaging Of Telomere Ends	R-HSA-171306	5.827308e-04	3.235	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.827308e-04	3.235	0	0
Signaling by Hippo	R-HSA-2028269	5.948318e-04	3.226	0	0
Signaling by ROBO receptors	R-HSA-376176	7.797653e-04	3.108	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.006429e-03	2.997	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.006429e-03	2.997	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.099169e-03	2.959	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.069467e-03	2.971	1	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.171075e-03	2.931	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.190759e-03	2.924	0	0
Cell-Cell communication	R-HSA-1500931	1.217350e-03	2.915	0	0
TRP channels	R-HSA-3295583	1.317293e-03	2.880	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.441077e-03	2.841	0	0
Signaling by VEGF	R-HSA-194138	1.530550e-03	2.815	1	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.547417e-03	2.810	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.627138e-03	2.789	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.973390e-03	2.705	0	0
Ion homeostasis	R-HSA-5578775	1.989890e-03	2.701	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.083109e-03	2.681	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.145167e-03	2.669	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.266376e-03	2.645	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.457562e-03	2.609	1	1
RET signaling	R-HSA-8853659	2.539706e-03	2.595	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.480750e-03	2.605	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.580257e-03	2.588	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.586682e-03	2.587	0	0
HDMs demethylate histones	R-HSA-3214842	2.913368e-03	2.536	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.923955e-03	2.534	0	0
Regulation of TP53 Expression	R-HSA-6804754	3.267373e-03	2.486	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	3.232033e-03	2.491	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.294977e-03	2.482	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.294977e-03	2.482	0	0
DAG and IP3 signaling	R-HSA-1489509	3.204742e-03	2.494	0	0
Cell junction organization	R-HSA-446728	3.015519e-03	2.521	0	0
Cardiac conduction	R-HSA-5576891	3.334539e-03	2.477	0	0
G2/M Checkpoints	R-HSA-69481	3.410295e-03	2.467	0	0
Signaling by RAF1 mutants	R-HSA-9656223	3.517699e-03	2.454	0	0
HDACs deacetylate histones	R-HSA-3214815	3.693421e-03	2.433	0	0
Homology Directed Repair	R-HSA-5693538	3.549293e-03	2.450	0	0
M Phase	R-HSA-68886	3.617764e-03	2.442	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.758648e-03	2.425	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.793649e-03	2.421	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.846629e-03	2.415	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.846629e-03	2.415	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	3.846629e-03	2.415	0	0
Signaling by RAS mutants	R-HSA-6802949	3.846629e-03	2.415	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	3.926627e-03	2.406	1	0
Meiotic recombination	R-HSA-912446	4.122626e-03	2.385	0	0
MECP2 regulates transcription factors	R-HSA-9022707	4.289898e-03	2.368	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.669006e-03	2.331	1	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.735549e-03	2.325	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.767744e-03	2.322	0	0
L1CAM interactions	R-HSA-373760	5.025033e-03	2.299	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.037269e-03	2.298	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.619802e-03	2.250	1	1
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.638369e-03	2.249	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.721624e-03	2.242	0	0
ESR-mediated signaling	R-HSA-8939211	6.005082e-03	2.221	1	0
Calmodulin induced events	R-HSA-111933	6.207517e-03	2.207	0	0
CaM pathway	R-HSA-111997	6.207517e-03	2.207	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.717767e-03	2.173	0	0
Neuronal System	R-HSA-112316	6.438392e-03	2.191	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.284926e-03	2.202	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.717767e-03	2.173	0	0
Specification of primordial germ cells	R-HSA-9827857	6.570191e-03	2.182	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.766024e-03	2.170	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.766024e-03	2.170	0	0
Nucleosome assembly	R-HSA-774815	7.210175e-03	2.142	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.210175e-03	2.142	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	7.496915e-03	2.125	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.496915e-03	2.125	0	0
Cleavage of the damaged purine	R-HSA-110331	7.496915e-03	2.125	0	0
Mitotic Prophase	R-HSA-68875	7.611555e-03	2.119	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.353637e-03	2.078	0	0
Long-term potentiation	R-HSA-9620244	7.909190e-03	2.102	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.578381e-03	2.067	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.619819e-03	2.065	0	0
Ephrin signaling	R-HSA-3928664	8.619819e-03	2.065	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.619819e-03	2.065	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.120741e-03	2.040	0	0
Amplification of signal from the kinetochores	R-HSA-141424	9.120741e-03	2.040	0	0
FOXO-mediated transcription	R-HSA-9614085	9.652685e-03	2.015	1	0
PIP3 activates AKT signaling	R-HSA-1257604	9.510493e-03	2.022	1	1
PLC beta mediated events	R-HSA-112043	9.219652e-03	2.035	0	0
MAPK family signaling cascades	R-HSA-5683057	9.432366e-03	2.025	0	0
Depurination	R-HSA-73927	8.990413e-03	2.046	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.552655e-03	2.020	0	0
Depyrimidination	R-HSA-73928	9.552655e-03	2.020	0	0
Apoptosis	R-HSA-109581	9.814146e-03	2.008	1	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.008145e-02	1.996	1	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.025501e-02	1.989	0	0
mRNA 3'-end processing	R-HSA-72187	1.027660e-02	1.988	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.055777e-02	1.976	0	0
Developmental Biology	R-HSA-1266738	1.069683e-02	1.971	1	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.074217e-02	1.969	0	0
CREB phosphorylation	R-HSA-199920	1.199743e-02	1.921	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.113986e-02	1.953	1	1
Germ layer formation at gastrulation	R-HSA-9754189	1.112103e-02	1.954	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.119126e-02	1.951	0	0
Defective pyroptosis	R-HSA-9710421	1.125195e-02	1.949	0	0
Semaphorin interactions	R-HSA-373755	1.210920e-02	1.917	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.211921e-02	1.917	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.312088e-02	1.882	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.312088e-02	1.882	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.312088e-02	1.882	0	0
Netrin-1 signaling	R-HSA-373752	1.317945e-02	1.880	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.412943e-02	1.850	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.457570e-02	1.836	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.469921e-02	1.833	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.431986e-02	1.844	0	0
Programmed Cell Death	R-HSA-5357801	1.528825e-02	1.816	1	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.551081e-02	1.809	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.576068e-02	1.802	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.625722e-02	1.789	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.625722e-02	1.789	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.671353e-02	1.777	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.743219e-02	1.759	0	0
DARPP-32 events	R-HSA-180024	1.785013e-02	1.748	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.792195e-02	1.747	0	0
Regulation of PTEN localization	R-HSA-8948747	1.803446e-02	1.744	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.874267e-02	1.727	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.167145e-02	1.664	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.167145e-02	1.664	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.167145e-02	1.664	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.984010e-02	1.702	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.058943e-02	1.686	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.953341e-02	1.709	0	0
MTOR signalling	R-HSA-165159	2.026917e-02	1.693	1	1
G-protein mediated events	R-HSA-112040	2.001197e-02	1.699	0	0
Recycling pathway of L1	R-HSA-437239	2.052318e-02	1.688	0	0
Ca-dependent events	R-HSA-111996	2.026917e-02	1.693	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.188597e-02	1.660	0	0
NrCAM interactions	R-HSA-447038	2.167145e-02	1.664	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.188597e-02	1.660	0	0
Interleukin-37 signaling	R-HSA-9008059	2.137534e-02	1.670	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.201056e-02	1.657	1	1
Regulation of endogenous retroelements	R-HSA-9842860	2.228827e-02	1.652	0	0
RAF activation	R-HSA-5673000	2.242370e-02	1.649	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.267220e-02	1.645	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	2.308504e-02	1.637	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	2.313552e-02	1.636	0	0
Co-stimulation by CD28	R-HSA-389356	2.355565e-02	1.628	1	0
Assembly of the pre-replicative complex	R-HSA-68867	2.399214e-02	1.620	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.579492e-02	1.588	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.579492e-02	1.588	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.586080e-02	1.587	0	0
Oncogene Induced Senescence	R-HSA-2559585	2.628622e-02	1.580	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.648626e-02	1.577	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.677036e-02	1.572	0	0
Opioid Signalling	R-HSA-111885	2.677448e-02	1.572	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.749903e-02	1.561	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.841943e-02	1.546	1	1
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.298338e-02	1.482	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.298338e-02	1.482	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.298338e-02	1.482	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.298338e-02	1.482	0	0
mRNA Splicing	R-HSA-72172	3.034682e-02	1.518	0	0
Mitotic Prometaphase	R-HSA-68877	2.951888e-02	1.530	0	0
Regulation of TP53 Degradation	R-HSA-6804757	3.061217e-02	1.514	1	1
Transcriptional Regulation by VENTX	R-HSA-8853884	3.089771e-02	1.510	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.233525e-02	1.490	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.233525e-02	1.490	0	0
Cell-cell junction organization	R-HSA-421270	3.091065e-02	1.510	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	3.016603e-02	1.520	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	3.456177e-02	1.461	0	0
Signaling by LTK	R-HSA-9842663	3.456177e-02	1.461	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.487935e-02	1.457	0	0
Adherens junctions interactions	R-HSA-418990	3.496990e-02	1.456	0	0
Integrin signaling	R-HSA-354192	3.499674e-02	1.456	1	1
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.499674e-02	1.456	0	0
Cardiogenesis	R-HSA-9733709	3.499674e-02	1.456	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.541524e-02	1.451	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	3.541524e-02	1.451	0	0
GP1b-IX-V activation signalling	R-HSA-430116	3.541524e-02	1.451	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.542772e-02	1.451	1	1
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.562881e-02	1.448	0	0
Chromosome Maintenance	R-HSA-73886	3.562881e-02	1.448	0	0
Nephrin family interactions	R-HSA-373753	3.619755e-02	1.441	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	3.644622e-02	1.438	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.644622e-02	1.438	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	3.644622e-02	1.438	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.644622e-02	1.438	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.644622e-02	1.438	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.644622e-02	1.438	0	0
Telomere Maintenance	R-HSA-157579	3.798810e-02	1.420	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.407402e-02	1.356	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.407402e-02	1.356	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.372987e-02	1.359	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.443089e-02	1.352	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.075715e-02	1.390	0	0
Platelet calcium homeostasis	R-HSA-418360	4.001129e-02	1.398	0	0
Neurexins and neuroligins	R-HSA-6794361	3.910377e-02	1.408	0	0
Signaling by WNT	R-HSA-195721	4.115157e-02	1.386	1	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.407402e-02	1.356	0	0
Rab regulation of trafficking	R-HSA-9007101	4.038222e-02	1.394	1	0
DNA Repair	R-HSA-73894	4.468989e-02	1.350	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.002589e-02	1.398	0	0
Signal attenuation	R-HSA-74749	4.698566e-02	1.328	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.698566e-02	1.328	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.826696e-02	1.316	1	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.916540e-02	1.308	0	0
MITF-M-dependent gene expression	R-HSA-9856651	4.926121e-02	1.307	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.928304e-02	1.307	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.172504e-02	1.286	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.172504e-02	1.286	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.172504e-02	1.286	0	0
Kinesins	R-HSA-983189	5.288482e-02	1.277	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	5.392975e-02	1.268	0	0
Trafficking of AMPA receptors	R-HSA-399719	5.408339e-02	1.267	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.413767e-02	1.267	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.507470e-02	1.259	0	0
Potassium Channels	R-HSA-1296071	5.561252e-02	1.255	0	0
G2/M Transition	R-HSA-69275	5.569345e-02	1.254	0	0
AURKA Activation by TPX2	R-HSA-8854518	5.623021e-02	1.250	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.845670e-02	1.233	0	0
MTF1 activates gene expression	R-HSA-5660489	6.175691e-02	1.209	0	0
HCN channels	R-HSA-1296061	6.175691e-02	1.209	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.175691e-02	1.209	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	6.175691e-02	1.209	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	6.423147e-02	1.192	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.423147e-02	1.192	0	0
DCC mediated attractive signaling	R-HSA-418885	6.759062e-02	1.170	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.759062e-02	1.170	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.759062e-02	1.170	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	5.953172e-02	1.225	0	0
PKA activation	R-HSA-163615	5.953172e-02	1.225	0	0
PKA activation in glucagon signalling	R-HSA-164378	5.953172e-02	1.225	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	6.220899e-02	1.206	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.108363e-02	1.148	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.003746e-02	1.222	1	1
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	6.489289e-02	1.188	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.953172e-02	1.225	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.435650e-02	1.191	0	0
Polo-like kinase mediated events	R-HSA-156711	5.953172e-02	1.225	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.953172e-02	1.225	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	7.108363e-02	1.148	0	0
DNA Replication Pre-Initiation	R-HSA-69002	6.813771e-02	1.167	0	0
Dopamine receptors	R-HSA-390651	6.175691e-02	1.209	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.464611e-02	1.189	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	6.669212e-02	1.176	1	0
Mitotic G2-G2/M phases	R-HSA-453274	6.234517e-02	1.205	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	6.470617e-02	1.189	1	0
Deubiquitination	R-HSA-5688426	6.984635e-02	1.156	0	0
FLT3 Signaling	R-HSA-9607240	6.003746e-02	1.222	1	1
Stimuli-sensing channels	R-HSA-2672351	6.336103e-02	1.198	0	0
Sensory processing of sound	R-HSA-9659379	6.755742e-02	1.170	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.090677e-02	1.215	0	0
Ub-specific processing proteases	R-HSA-5689880	7.265669e-02	1.139	0	0
Epigenetic regulation of gene expression	R-HSA-212165	7.344548e-02	1.134	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.440806e-02	1.128	0	0
Breakdown of the nuclear lamina	R-HSA-352238	7.449350e-02	1.128	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	7.449350e-02	1.128	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.449350e-02	1.128	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.579538e-02	1.120	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.610470e-02	1.119	0	0
Amyloid fiber formation	R-HSA-977225	7.982130e-02	1.098	0	0
Separation of Sister Chromatids	R-HSA-2467813	8.055158e-02	1.094	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.071761e-02	1.093	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.124515e-02	1.090	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.162387e-02	1.088	0	0
Regulation of gene expression in beta cells	R-HSA-210745	8.259763e-02	1.083	1	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.270720e-02	1.082	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	8.314283e-02	1.080	1	0
Formation of definitive endoderm	R-HSA-9823730	8.368379e-02	1.077	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	8.408261e-02	1.075	0	0
Type I hemidesmosome assembly	R-HSA-446107	8.408261e-02	1.075	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	8.822630e-02	1.054	0	0
IRS activation	R-HSA-74713	8.822630e-02	1.054	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	8.822630e-02	1.054	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	8.822630e-02	1.054	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.847996e-02	1.053	0	0
Signaling by ERBB2	R-HSA-1227986	8.975451e-02	1.047	1	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	9.016504e-02	1.045	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	9.360714e-02	1.029	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	9.360714e-02	1.029	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.398523e-02	1.027	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.398523e-02	1.027	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	9.611570e-02	1.017	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.628179e-02	1.016	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.204596e-01	0.919	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	1.204596e-01	0.919	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.204596e-01	0.919	0	0
Diseases of cellular response to stress	R-HSA-9675132	1.204596e-01	0.919	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.204596e-01	0.919	0	0
Diseases of Cellular Senescence	R-HSA-9630747	1.204596e-01	0.919	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	1.204596e-01	0.919	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.204596e-01	0.919	0	0
C6 deamination of adenosine	R-HSA-75102	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.204596e-01	0.919	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.204596e-01	0.919	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.204596e-01	0.919	0	0
Potassium transport channels	R-HSA-1296067	1.204596e-01	0.919	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.185950e-01	0.926	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.185950e-01	0.926	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.185950e-01	0.926	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	1.185950e-01	0.926	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.088201e-01	0.963	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.162517e-01	0.935	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.162517e-01	0.935	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.041541e-01	0.982	0	0
Hedgehog 'off' state	R-HSA-5610787	1.129060e-01	0.947	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.039701e-01	0.983	1	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.040011e-01	0.983	1	1
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.033347e-01	0.986	0	0
Frs2-mediated activation	R-HSA-170968	1.129750e-01	0.947	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.193540e-01	0.923	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.022769e-01	0.990	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.065561e-01	0.972	0	0
Signalling to ERKs	R-HSA-187687	1.022769e-01	0.990	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.147740e-01	0.940	1	1
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.147740e-01	0.940	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.129617e-01	0.947	0	0
Transmission across Chemical Synapses	R-HSA-112315	1.183774e-01	0.927	0	0
Mitotic Anaphase	R-HSA-68882	1.080320e-01	0.966	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.185950e-01	0.926	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.185950e-01	0.926	0	0
Signaling by TGFBR3	R-HSA-9839373	1.145775e-01	0.941	0	0
Signaling by Interleukins	R-HSA-449147	1.019005e-01	0.992	1	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.205982e-01	0.919	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	1.205982e-01	0.919	0	0
Centrosome maturation	R-HSA-380287	1.214388e-01	0.916	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.243536e-01	0.905	1	1
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.274288e-01	0.895	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.289101e-01	0.890	0	0
mTORC1-mediated signalling	R-HSA-166208	1.289101e-01	0.890	0	0
Smooth Muscle Contraction	R-HSA-445355	1.300024e-01	0.886	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.306811e-01	0.884	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.314264e-01	0.881	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.325009e-01	0.878	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.325009e-01	0.878	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.325009e-01	0.878	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.328188e-01	0.877	0	0
G-protein beta:gamma signalling	R-HSA-397795	1.333026e-01	0.875	1	0
Regulation of KIT signaling	R-HSA-1433559	1.340943e-01	0.873	0	0
cGMP effects	R-HSA-418457	1.340943e-01	0.873	0	0
HDL assembly	R-HSA-8963896	1.340943e-01	0.873	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.362305e-01	0.866	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.368978e-01	0.864	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.383547e-01	0.859	1	1
Drug resistance of KIT mutants	R-HSA-9669937	1.383628e-01	0.859	0	0
KIT mutants bind TKIs	R-HSA-9669921	1.383628e-01	0.859	0	0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.383628e-01	0.859	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.383628e-01	0.859	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.383628e-01	0.859	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.383628e-01	0.859	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.383628e-01	0.859	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.383628e-01	0.859	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.383628e-01	0.859	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.383628e-01	0.859	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	1.383628e-01	0.859	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.383628e-01	0.859	0	0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.383628e-01	0.859	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	1.383628e-01	0.859	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.383628e-01	0.859	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.714267e-01	0.766	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.714267e-01	0.766	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.522108e-01	0.818	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.522108e-01	0.818	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.883982e-01	0.725	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.883982e-01	0.725	0	0
Ca2+ activated K+ channels	R-HSA-1296052	1.883982e-01	0.725	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.883982e-01	0.725	0	0
SOS-mediated signalling	R-HSA-112412	1.883982e-01	0.725	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.883982e-01	0.725	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.883982e-01	0.725	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.584243e-01	0.800	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.872522e-01	0.728	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.568240e-01	0.805	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.568240e-01	0.805	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.521740e-01	0.818	0	0
Differentiation of T cells	R-HSA-9945266	1.810023e-01	0.742	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.810023e-01	0.742	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.810023e-01	0.742	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.810023e-01	0.742	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.730548e-01	0.762	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.730548e-01	0.762	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.730548e-01	0.762	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.730548e-01	0.762	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.730548e-01	0.762	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.562198e-01	0.806	0	0
Striated Muscle Contraction	R-HSA-390522	1.480605e-01	0.830	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.734700e-01	0.761	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.635948e-01	0.786	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.444579e-01	0.840	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.462489e-01	0.835	1	1
Regulation of TNFR1 signaling	R-HSA-5357905	1.879230e-01	0.726	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.791123e-01	0.747	1	1
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.872522e-01	0.728	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.635948e-01	0.786	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.883982e-01	0.725	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.521740e-01	0.818	0	0
Generation of second messenger molecules	R-HSA-202433	1.691129e-01	0.772	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.786705e-01	0.748	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.503447e-01	0.823	0	0
Prolonged ERK activation events	R-HSA-169893	1.810023e-01	0.742	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	1.480605e-01	0.830	0	0
Membrane Trafficking	R-HSA-199991	1.561007e-01	0.807	1	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.562198e-01	0.806	0	0
Protein ubiquitination	R-HSA-8852135	1.822594e-01	0.739	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.568240e-01	0.805	1	1
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.625906e-01	0.789	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.872522e-01	0.728	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.657496e-01	0.781	1	0
The NLRP3 inflammasome	R-HSA-844456	1.521740e-01	0.818	0	0
TGFBR3 expression	R-HSA-9839394	1.839692e-01	0.735	0	0
Signaling by NTRKs	R-HSA-166520	1.660421e-01	0.780	0	0
Formation of the nephric duct	R-HSA-9830364	1.839692e-01	0.735	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.814543e-01	0.741	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.814543e-01	0.741	0	0
STING mediated induction of host immune responses	R-HSA-1834941	1.521740e-01	0.818	0	0
Base Excision Repair	R-HSA-73884	1.621635e-01	0.790	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.568240e-01	0.805	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.903606e-01	0.720	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.575882e-01	0.589	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.575882e-01	0.589	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.575882e-01	0.589	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.575882e-01	0.589	0	0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.575882e-01	0.589	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.575882e-01	0.589	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.575882e-01	0.589	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.575882e-01	0.589	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.575882e-01	0.589	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	2.251321e-01	0.648	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.251321e-01	0.648	1	1
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.251321e-01	0.648	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.251321e-01	0.648	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.251321e-01	0.648	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.251321e-01	0.648	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.603222e-01	0.443	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.603222e-01	0.443	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.603222e-01	0.443	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.603222e-01	0.443	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.603222e-01	0.443	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.603222e-01	0.443	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.603222e-01	0.443	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.603222e-01	0.443	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.603222e-01	0.443	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.603222e-01	0.443	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.603222e-01	0.443	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.603222e-01	0.443	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.603222e-01	0.443	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.603222e-01	0.443	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.603222e-01	0.443	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.603222e-01	0.443	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.603222e-01	0.443	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.603222e-01	0.443	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.603222e-01	0.443	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.603222e-01	0.443	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.603222e-01	0.443	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.603222e-01	0.443	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.603222e-01	0.443	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.603222e-01	0.443	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.603222e-01	0.443	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.603222e-01	0.443	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.603222e-01	0.443	0	0
Intestinal infectious diseases	R-HSA-8942233	3.603222e-01	0.443	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.603222e-01	0.443	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.603222e-01	0.443	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.798433e-01	0.553	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.798433e-01	0.553	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.264953e-01	0.645	0	0
RSK activation	R-HSA-444257	2.264953e-01	0.645	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.264953e-01	0.645	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.264953e-01	0.645	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	2.175972e-01	0.662	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.175972e-01	0.662	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.175972e-01	0.662	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.175972e-01	0.662	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.175972e-01	0.662	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.175972e-01	0.662	0	0
Lipophagy	R-HSA-9613354	2.658780e-01	0.575	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.342544e-01	0.476	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.342544e-01	0.476	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.342544e-01	0.476	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.342544e-01	0.476	0	0
Signaling by MAPK mutants	R-HSA-9652817	3.342544e-01	0.476	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.488451e-01	0.348	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.488451e-01	0.348	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.488451e-01	0.348	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.488451e-01	0.348	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.488451e-01	0.348	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.488451e-01	0.348	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.488451e-01	0.348	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.488451e-01	0.348	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.064521e-01	0.685	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.064521e-01	0.685	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.491416e-01	0.604	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.491416e-01	0.604	1	1
Formation of axial mesoderm	R-HSA-9796292	2.491416e-01	0.604	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.491416e-01	0.604	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.491416e-01	0.604	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.950336e-01	0.710	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.059760e-01	0.514	0	0
Folding of actin by CCT/TriC	R-HSA-390450	3.059760e-01	0.514	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.059760e-01	0.514	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.059760e-01	0.514	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.329860e-01	0.633	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.815729e-01	0.550	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.815729e-01	0.550	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.874012e-01	0.412	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	3.874012e-01	0.412	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.874012e-01	0.412	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.604115e-01	0.584	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.604115e-01	0.584	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.462808e-01	0.461	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	3.462808e-01	0.461	0	0
Signaling by APC mutants	R-HSA-4839744	3.462808e-01	0.461	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.462808e-01	0.461	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.462808e-01	0.461	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.462808e-01	0.461	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.252270e-01	0.647	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.252270e-01	0.647	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.103287e-01	0.677	0	0
Erythropoietin activates RAS	R-HSA-9027284	3.145900e-01	0.502	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.145900e-01	0.502	1	1
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.145900e-01	0.502	0	0
Interleukin receptor SHC signaling	R-HSA-912526	2.663271e-01	0.575	0	0
Voltage gated Potassium channels	R-HSA-1296072	2.144421e-01	0.669	0	0
Signaling by Erythropoietin	R-HSA-9006335	2.693068e-01	0.570	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.693068e-01	0.570	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	2.914417e-01	0.535	0	0
Co-inhibition by CTLA4	R-HSA-389513	3.171658e-01	0.499	1	1
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.171658e-01	0.499	0	0
Phosphorylation of the APC/C	R-HSA-176412	3.479095e-01	0.459	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	3.863494e-01	0.413	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.385922e-01	0.358	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.385922e-01	0.358	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.385922e-01	0.358	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.385922e-01	0.358	0	0
Disinhibition of SNARE formation	R-HSA-114516	4.385922e-01	0.358	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.385922e-01	0.358	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.251220e-01	0.280	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	5.251220e-01	0.280	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.251220e-01	0.280	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	5.251220e-01	0.280	0	0
Classical Kir channels	R-HSA-1296053	5.251220e-01	0.280	0	0
Defective ABCA1 causes TGD	R-HSA-5682113	5.251220e-01	0.280	0	0
Invadopodia formation	R-HSA-8941237	5.251220e-01	0.280	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.251220e-01	0.280	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.251220e-01	0.280	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.048468e-01	0.689	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	3.170092e-01	0.499	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	3.170092e-01	0.499	0	0
Tight junction interactions	R-HSA-420029	3.170092e-01	0.499	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.170092e-01	0.499	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.461191e-01	0.461	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.812694e-01	0.419	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.258046e-01	0.371	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.258046e-01	0.371	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.102120e-01	0.508	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.689794e-01	0.433	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.689794e-01	0.433	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.689794e-01	0.433	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	4.144314e-01	0.383	0	0
Regulation by c-FLIP	R-HSA-3371378	4.873510e-01	0.312	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.873510e-01	0.312	0	0
Dimerization of procaspase-8	R-HSA-69416	4.873510e-01	0.312	0	0
Formation of annular gap junctions	R-HSA-196025	4.873510e-01	0.312	0	0
FGFR1b ligand binding and activation	R-HSA-190370	4.873510e-01	0.312	0	0
Activation of RAS in B cells	R-HSA-1169092	4.873510e-01	0.312	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.037970e-01	0.517	0	0
HIV elongation arrest and recovery	R-HSA-167287	3.951313e-01	0.403	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.951313e-01	0.403	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	3.951313e-01	0.403	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.951313e-01	0.403	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.643327e-01	0.333	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.833031e-01	0.548	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.789385e-01	0.421	0	0
Late endosomal microautophagy	R-HSA-9615710	4.212368e-01	0.375	0	0
HIV Transcription Elongation	R-HSA-167169	4.011471e-01	0.397	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.011471e-01	0.397	0	0
Attenuation phase	R-HSA-3371568	4.011471e-01	0.397	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.011471e-01	0.397	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.068355e-01	0.513	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.068355e-01	0.513	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.394849e-01	0.469	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.471864e-01	0.350	0	0
Activation of the pre-replicative complex	R-HSA-68962	4.471864e-01	0.350	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.471864e-01	0.350	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.617979e-01	0.336	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.793376e-01	0.319	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.793376e-01	0.319	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.793376e-01	0.319	0	0
Removal of the Flap Intermediate	R-HSA-69166	5.016790e-01	0.300	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.333706e-01	0.273	0	0
WNT mediated activation of DVL	R-HSA-201688	5.333706e-01	0.273	0	0
Gap junction degradation	R-HSA-190873	5.333706e-01	0.273	0	0
CASP8 activity is inhibited	R-HSA-5218900	5.333706e-01	0.273	0	0
ALK mutants bind TKIs	R-HSA-9700645	5.333706e-01	0.273	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.107345e-01	0.292	0	0
Spry regulation of FGF signaling	R-HSA-1295596	5.376432e-01	0.270	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.376432e-01	0.270	0	0
SHC1 events in EGFR signaling	R-HSA-180336	5.376432e-01	0.270	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.376432e-01	0.270	0	0
Cellular response to heat stress	R-HSA-3371556	4.501578e-01	0.347	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.412385e-01	0.267	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	5.412385e-01	0.267	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.279159e-01	0.277	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.444991e-01	0.264	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.475256e-01	0.262	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.475256e-01	0.262	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.720740e-01	0.243	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.503678e-01	0.259	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.503678e-01	0.259	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	5.530574e-01	0.257	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.707380e-01	0.244	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.707380e-01	0.244	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.556172e-01	0.255	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.514091e-01	0.259	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.707123e-01	0.244	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.707123e-01	0.244	0	0
Formation of the Early Elongation Complex	R-HSA-113418	5.707123e-01	0.244	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.501578e-01	0.347	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.568039e-01	0.448	0	0
EGFR downregulation	R-HSA-182971	4.728787e-01	0.325	0	0
Regulation of necroptotic cell death	R-HSA-5675482	2.298090e-01	0.639	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.049576e-01	0.393	1	1
IGF1R signaling cascade	R-HSA-2428924	3.875084e-01	0.412	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.735627e-01	0.241	0	0
Specification of the neural plate border	R-HSA-9834899	2.885350e-01	0.540	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.939747e-01	0.306	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.867265e-01	0.413	0	0
Signaling by FGFR4	R-HSA-5654743	4.893294e-01	0.310	0	0
Signaling by SCF-KIT	R-HSA-1433557	3.509920e-01	0.455	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.462858e-01	0.609	1	1
Signaling by EGFR	R-HSA-177929	2.509731e-01	0.600	0	0
Nucleotide Excision Repair	R-HSA-5696398	3.837421e-01	0.416	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.818172e-01	0.317	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	5.720740e-01	0.243	0	0
Telomere Extension By Telomerase	R-HSA-171319	5.707123e-01	0.244	0	0
mRNA Editing	R-HSA-75072	2.658780e-01	0.575	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.064521e-01	0.685	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.291586e-01	0.640	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.516314e-01	0.599	0	0
G0 and Early G1	R-HSA-1538133	4.982206e-01	0.303	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.175504e-01	0.286	0	0
Signaling by FGFR3	R-HSA-5654741	5.321530e-01	0.274	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.428977e-01	0.465	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	2.652882e-01	0.576	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.444991e-01	0.264	0	0
Aggrephagy	R-HSA-9646399	4.011471e-01	0.397	0	0
RMTs methylate histone arginines	R-HSA-3214858	2.518781e-01	0.599	0	0
TNF signaling	R-HSA-75893	2.509731e-01	0.600	0	0
ERK/MAPK targets	R-HSA-198753	1.950336e-01	0.710	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.376432e-01	0.270	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.782610e-01	0.556	1	1
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.036945e-01	0.298	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.498969e-01	0.602	0	0
p75NTR signals via NF-kB	R-HSA-193639	5.376432e-01	0.270	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.197243e-01	0.658	1	1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.052894e-01	0.392	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.658780e-01	0.575	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.059760e-01	0.514	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.298090e-01	0.639	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	5.503678e-01	0.259	1	1
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.970433e-01	0.401	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.970433e-01	0.401	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.469797e-01	0.607	0	0
Cyclin D associated events in G1	R-HSA-69231	5.108940e-01	0.292	0	0
G1 Phase	R-HSA-69236	5.108940e-01	0.292	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.812694e-01	0.419	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.453806e-01	0.462	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.453806e-01	0.462	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	4.899506e-01	0.310	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	2.658780e-01	0.575	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	3.342544e-01	0.476	0	0
Regulation of CDH11 function	R-HSA-9762292	3.059760e-01	0.514	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.059760e-01	0.514	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	3.059760e-01	0.514	0	0
Nuclear RNA decay	R-HSA-9930044	2.298090e-01	0.639	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.385922e-01	0.358	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	5.376432e-01	0.270	0	0
Peptide chain elongation	R-HSA-156902	4.767486e-01	0.322	0	0
Signalling to RAS	R-HSA-167044	5.412385e-01	0.267	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.720740e-01	0.243	0	0
Apoptotic factor-mediated response	R-HSA-111471	2.604115e-01	0.584	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.921635e-01	0.534	1	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.705184e-01	0.568	0	0
Eukaryotic Translation Elongation	R-HSA-156842	3.539288e-01	0.451	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.753953e-01	0.323	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.175972e-01	0.662	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.658780e-01	0.575	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.258046e-01	0.371	0	0
Adrenoceptors	R-HSA-390696	4.873510e-01	0.312	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.873510e-01	0.312	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.296849e-01	0.482	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.332050e-01	0.363	1	1
TCR signaling	R-HSA-202403	3.637439e-01	0.439	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	4.721935e-01	0.326	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.395474e-01	0.469	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.428977e-01	0.465	0	0
Autophagy	R-HSA-9612973	2.963176e-01	0.528	0	0
Regulated Necrosis	R-HSA-5218859	3.463300e-01	0.461	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	3.059760e-01	0.514	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.005560e-01	0.698	0	0
Repression of WNT target genes	R-HSA-4641265	4.258046e-01	0.371	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	4.212368e-01	0.375	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.720740e-01	0.243	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.395474e-01	0.469	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.775270e-01	0.423	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.804000e-01	0.318	1	0
GPER1 signaling	R-HSA-9634597	2.188498e-01	0.660	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.036204e-01	0.691	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.723063e-01	0.326	0	0
Selective autophagy	R-HSA-9663891	3.750740e-01	0.426	0	0
Signaling by Hedgehog	R-HSA-5358351	2.976741e-01	0.526	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.504292e-01	0.455	0	0
S Phase	R-HSA-69242	2.181712e-01	0.661	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.036204e-01	0.691	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.036204e-01	0.691	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.775270e-01	0.423	0	0
Signaling by WNT in cancer	R-HSA-4791275	4.982206e-01	0.303	0	0
Integration of energy metabolism	R-HSA-163685	2.759660e-01	0.559	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.422960e-01	0.354	0	0
Hedgehog 'on' state	R-HSA-5632684	2.935401e-01	0.532	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.658780e-01	0.575	0	0
Abacavir transmembrane transport	R-HSA-2161517	3.874012e-01	0.412	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	3.863494e-01	0.413	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.873510e-01	0.312	0	0
TGFBR3 PTM regulation	R-HSA-9839383	4.873510e-01	0.312	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.873510e-01	0.312	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.873510e-01	0.312	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.628102e-01	0.440	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.628102e-01	0.440	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.867265e-01	0.413	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.106706e-01	0.387	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	2.905526e-01	0.537	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.321530e-01	0.274	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.580644e-01	0.253	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.580644e-01	0.253	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.580644e-01	0.253	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.580644e-01	0.253	0	0
Macroautophagy	R-HSA-1632852	4.076295e-01	0.390	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.090622e-01	0.510	1	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.372238e-01	0.472	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.488413e-01	0.457	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.298090e-01	0.639	1	1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.867265e-01	0.413	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.503678e-01	0.259	0	0
Diseases of Immune System	R-HSA-5260271	5.503678e-01	0.259	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.812694e-01	0.419	0	0
Signaling by FGFR in disease	R-HSA-1226099	4.482290e-01	0.349	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.117544e-01	0.674	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.304879e-01	0.481	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.117544e-01	0.674	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.578136e-01	0.446	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.258046e-01	0.371	1	1
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.041778e-01	0.393	0	0
Interleukin-2 family signaling	R-HSA-451927	4.011471e-01	0.397	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.345548e-01	0.362	0	0
G1/S Transition	R-HSA-69206	4.291033e-01	0.367	1	0
Cellular responses to stress	R-HSA-2262752	4.695078e-01	0.328	1	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.251321e-01	0.648	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.145900e-01	0.502	1	1
FGFR1 mutant receptor activation	R-HSA-1839124	2.298090e-01	0.639	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.326440e-01	0.633	0	0
Signaling by NOTCH1	R-HSA-1980143	4.821911e-01	0.317	0	0
PTEN Regulation	R-HSA-6807070	5.472655e-01	0.262	1	0
Platelet activation, signaling and aggregation	R-HSA-76002	3.878698e-01	0.411	1	0
Cellular responses to stimuli	R-HSA-8953897	2.915927e-01	0.535	1	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.601449e-01	0.444	0	0
Metabolism of RNA	R-HSA-8953854	5.660646e-01	0.247	1	0
Interleukin-1 family signaling	R-HSA-446652	2.559933e-01	0.592	0	0
Signaling by TGFB family members	R-HSA-9006936	5.658278e-01	0.247	0	0
Neurofascin interactions	R-HSA-447043	3.874012e-01	0.412	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.915975e-01	0.535	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.812694e-01	0.419	0	0
DNA Replication	R-HSA-69306	2.658576e-01	0.575	0	0
Protein methylation	R-HSA-8876725	3.145900e-01	0.502	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.140961e-01	0.383	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.369240e-01	0.625	0	0
Signaling by ERBB4	R-HSA-1236394	2.469797e-01	0.607	0	0
Ca2+ pathway	R-HSA-4086398	5.458052e-01	0.263	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.628102e-01	0.440	0	0
Inhibition of PKR	R-HSA-169131	2.575882e-01	0.589	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.264953e-01	0.645	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.658780e-01	0.575	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.488451e-01	0.348	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.491416e-01	0.604	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	3.462808e-01	0.461	0	0
Bicarbonate transporters	R-HSA-425381	3.462808e-01	0.461	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.479095e-01	0.459	0	0
Signaling by AXIN mutants	R-HSA-4839735	3.863494e-01	0.413	0	0
Signaling by AMER1 mutants	R-HSA-4839748	3.863494e-01	0.413	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.385922e-01	0.358	0	0
MET interacts with TNS proteins	R-HSA-8875513	5.251220e-01	0.280	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.705184e-01	0.568	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.873510e-01	0.312	1	1
Co-stimulation by ICOS	R-HSA-9927354	4.873510e-01	0.312	0	0
MAP kinase activation	R-HSA-450294	3.347368e-01	0.475	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.212368e-01	0.375	0	0
Unwinding of DNA	R-HSA-176974	5.333706e-01	0.273	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.175504e-01	0.286	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	4.818585e-01	0.317	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.412385e-01	0.267	0	0
Cristae formation	R-HSA-8949613	5.444991e-01	0.264	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	5.707123e-01	0.244	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.884321e-01	0.311	1	0
Signaling by PTK6	R-HSA-8848021	4.884321e-01	0.311	1	0
Activation of BH3-only proteins	R-HSA-114452	2.921635e-01	0.534	1	0
Regulation of insulin secretion	R-HSA-422356	3.622071e-01	0.441	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.321530e-01	0.274	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.707123e-01	0.244	0	0
Interleukin-17 signaling	R-HSA-448424	4.939747e-01	0.306	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	5.197525e-01	0.284	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.175972e-01	0.662	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.957287e-01	0.708	1	0
Downstream signal transduction	R-HSA-186763	4.728787e-01	0.325	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.658780e-01	0.575	0	0
TBC/RABGAPs	R-HSA-8854214	2.342745e-01	0.630	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.752185e-01	0.426	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.873510e-01	0.312	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.752185e-01	0.426	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.628102e-01	0.440	0	0
Pyroptosis	R-HSA-5620971	5.707123e-01	0.244	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.921635e-01	0.534	0	0
RUNX2 regulates bone development	R-HSA-8941326	4.582962e-01	0.339	0	0
Interleukin-1 processing	R-HSA-448706	2.658780e-01	0.575	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.491416e-01	0.604	0	0
Nef and signal transduction	R-HSA-164944	3.874012e-01	0.412	0	0
Syndecan interactions	R-HSA-3000170	2.663271e-01	0.575	0	0
CHL1 interactions	R-HSA-447041	4.385922e-01	0.358	0	0
RAB geranylgeranylation	R-HSA-8873719	2.201786e-01	0.657	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	4.144314e-01	0.383	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.333706e-01	0.273	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.333706e-01	0.273	0	0
Protein hydroxylation	R-HSA-9629569	5.107345e-01	0.292	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.252270e-01	0.647	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.713471e-01	0.243	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.580644e-01	0.253	0	0
Signaling by NOTCH	R-HSA-157118	2.160802e-01	0.665	1	0
Ion channel transport	R-HSA-983712	3.156618e-01	0.501	0	0
Kidney development	R-HSA-9830369	4.409136e-01	0.356	0	0
Signaling by NOTCH3	R-HSA-9012852	4.628520e-01	0.335	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.860959e-01	0.543	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.643327e-01	0.333	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.752131e-01	0.560	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	4.172816e-01	0.380	1	0
Interleukin-15 signaling	R-HSA-8983432	4.258046e-01	0.371	0	0
PI Metabolism	R-HSA-1483255	2.491824e-01	0.603	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.875084e-01	0.412	0	0
Co-inhibition by PD-1	R-HSA-389948	5.668773e-01	0.247	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.298090e-01	0.639	0	0
DSCAM interactions	R-HSA-376172	4.488451e-01	0.348	0	0
Tandem pore domain potassium channels	R-HSA-1296346	3.059760e-01	0.514	0	0
Synthesis of PI	R-HSA-1483226	3.462808e-01	0.461	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.251220e-01	0.280	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	5.251220e-01	0.280	0	0
Alpha-defensins	R-HSA-1462054	4.873510e-01	0.312	0	0
Physiological factors	R-HSA-5578768	5.016790e-01	0.300	0	0
ARMS-mediated activation	R-HSA-170984	5.333706e-01	0.273	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.432948e-01	0.353	0	0
Negative regulation of FLT3	R-HSA-9706369	5.720740e-01	0.243	0	0
Inflammasomes	R-HSA-622312	3.951313e-01	0.403	0	0
Plasma lipoprotein assembly	R-HSA-8963898	4.617979e-01	0.336	0	0
Signaling by ALK	R-HSA-201556	2.513817e-01	0.600	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.041986e-01	0.690	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.414771e-01	0.617	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	3.461191e-01	0.461	0	0
Histamine receptors	R-HSA-390650	5.251220e-01	0.280	0	0
G1/S-Specific Transcription	R-HSA-69205	3.130566e-01	0.504	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.333706e-01	0.273	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.376432e-01	0.270	0	0
Formation of the anterior neural plate	R-HSA-9823739	5.376432e-01	0.270	0	0
Diseases of DNA repair	R-HSA-9675135	4.132525e-01	0.384	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.488451e-01	0.348	0	0
NADPH regeneration	R-HSA-389542	3.874012e-01	0.412	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	4.385922e-01	0.358	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.251220e-01	0.280	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	5.251220e-01	0.280	0	0
Sodium/Proton exchangers	R-HSA-425986	4.873510e-01	0.312	0	0
Interleukin-18 signaling	R-HSA-9012546	4.873510e-01	0.312	0	0
Interleukin-7 signaling	R-HSA-1266695	3.170092e-01	0.499	0	0
Regulation of beta-cell development	R-HSA-186712	4.141261e-01	0.383	1	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.547874e-01	0.342	0	0
Leukotriene receptors	R-HSA-391906	3.874012e-01	0.412	0	0
FasL/ CD95L signaling	R-HSA-75157	5.251220e-01	0.280	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	4.471830e-01	0.350	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	4.643327e-01	0.333	0	0
SARS-CoV-1 Infection	R-HSA-9678108	4.426368e-01	0.354	0	0
Interleukin-12 signaling	R-HSA-9020591	2.754607e-01	0.560	0	0
Gene Silencing by RNA	R-HSA-211000	5.053114e-01	0.296	0	0
Interleukin-12 family signaling	R-HSA-447115	4.609938e-01	0.336	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.764753e-01	0.239	0	0
Regulation of the apoptosome activity	R-HSA-9627069	5.764753e-01	0.239	0	0
Formation of apoptosome	R-HSA-111458	5.764753e-01	0.239	0	0
PI3K/AKT activation	R-HSA-198203	5.764753e-01	0.239	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.764753e-01	0.239	0	0
Signaling by Leptin	R-HSA-2586552	5.764753e-01	0.239	0	0
Transcription of the HIV genome	R-HSA-167172	5.777980e-01	0.238	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.806878e-01	0.236	0	0
Glycolysis	R-HSA-70171	5.853179e-01	0.233	0	0
Platelet homeostasis	R-HSA-418346	5.868071e-01	0.232	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.882837e-01	0.230	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.908464e-01	0.229	0	0
ATP sensitive Potassium channels	R-HSA-1296025	5.908464e-01	0.229	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.908464e-01	0.229	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.908464e-01	0.229	0	0
Defective MAT1A causes MATD	R-HSA-5579024	5.908464e-01	0.229	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.908464e-01	0.229	0	0
Regulation of gap junction activity	R-HSA-191650	5.908464e-01	0.229	0	0
Alanine metabolism	R-HSA-8964540	5.908464e-01	0.229	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.908464e-01	0.229	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.908464e-01	0.229	0	0
Sensory perception of sour taste	R-HSA-9729555	5.908464e-01	0.229	0	0
NADE modulates death signalling	R-HSA-205025	5.908464e-01	0.229	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.908464e-01	0.229	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.908464e-01	0.229	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.938084e-01	0.226	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.938084e-01	0.226	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.938084e-01	0.226	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.961191e-01	0.225	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.961191e-01	0.225	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	5.961191e-01	0.225	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.984158e-01	0.223	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	5.991441e-01	0.222	0	0
FGFR2 alternative splicing	R-HSA-6803529	5.991441e-01	0.222	0	0
Notch-HLH transcription pathway	R-HSA-350054	5.991441e-01	0.222	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.991441e-01	0.222	0	0
Interleukin-1 signaling	R-HSA-9020702	5.994434e-01	0.222	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	6.026843e-01	0.220	1	0
Cilium Assembly	R-HSA-5617833	6.048081e-01	0.218	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.048631e-01	0.218	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.048631e-01	0.218	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.048631e-01	0.218	0	0
Phase 2 - plateau phase	R-HSA-5576893	6.048631e-01	0.218	0	0
Disorders of Developmental Biology	R-HSA-9675151	6.048631e-01	0.218	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.048631e-01	0.218	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.048631e-01	0.218	0	0
Response to metal ions	R-HSA-5660526	6.048631e-01	0.218	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.117010e-01	0.213	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.118277e-01	0.213	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.123154e-01	0.213	0	0
Signaling by FGFR1	R-HSA-5654736	6.123154e-01	0.213	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	6.127872e-01	0.213	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.165905e-01	0.210	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	6.165905e-01	0.210	0	0
LGI-ADAM interactions	R-HSA-5682910	6.165905e-01	0.210	0	0
Formation of the posterior neural plate	R-HSA-9832991	6.165905e-01	0.210	0	0
Interleukin-2 signaling	R-HSA-9020558	6.165905e-01	0.210	0	0
PECAM1 interactions	R-HSA-210990	6.165905e-01	0.210	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.170409e-01	0.210	0	0
HSF1 activation	R-HSA-3371511	6.170409e-01	0.210	0	0
RNA Polymerase III Transcription	R-HSA-74158	6.170409e-01	0.210	0	0
Triglyceride catabolism	R-HSA-163560	6.170409e-01	0.210	0	0
FLT3 signaling in disease	R-HSA-9682385	6.170409e-01	0.210	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.205337e-01	0.207	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.206614e-01	0.207	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.206614e-01	0.207	0	0
DAP12 signaling	R-HSA-2424491	6.206614e-01	0.207	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.263888e-01	0.203	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.263888e-01	0.203	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.269181e-01	0.203	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.269194e-01	0.203	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.290109e-01	0.201	0	0
Ion transport by P-type ATPases	R-HSA-936837	6.290109e-01	0.201	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	6.303770e-01	0.200	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.359401e-01	0.197	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.359401e-01	0.197	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.359401e-01	0.197	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.359401e-01	0.197	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.359401e-01	0.197	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.359401e-01	0.197	0	0
Ovarian tumor domain proteases	R-HSA-5689896	6.388238e-01	0.195	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.405038e-01	0.193	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.428679e-01	0.192	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	6.442932e-01	0.191	0	0
Activation of AMPA receptors	R-HSA-399710	6.474776e-01	0.189	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.474776e-01	0.189	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	6.474776e-01	0.189	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.474776e-01	0.189	0	0
Defective F9 activation	R-HSA-9673221	6.474776e-01	0.189	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.474776e-01	0.189	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.474776e-01	0.189	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.474776e-01	0.189	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.474776e-01	0.189	0	0
Activation of AKT2	R-HSA-165158	6.474776e-01	0.189	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.474776e-01	0.189	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.474776e-01	0.189	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	6.474776e-01	0.189	0	0
PTK6 Down-Regulation	R-HSA-8849472	6.474776e-01	0.189	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	6.474776e-01	0.189	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.474776e-01	0.189	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	6.474776e-01	0.189	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.474776e-01	0.189	0	0
Developmental Cell Lineages	R-HSA-9734767	6.516544e-01	0.186	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.524228e-01	0.185	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.524228e-01	0.185	0	0
Deadenylation of mRNA	R-HSA-429947	6.524228e-01	0.185	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.524228e-01	0.185	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.524228e-01	0.185	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.524228e-01	0.185	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.537179e-01	0.185	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.537179e-01	0.185	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	6.537179e-01	0.185	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.537179e-01	0.185	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	6.537179e-01	0.185	0	0
ERKs are inactivated	R-HSA-202670	6.537179e-01	0.185	0	0
NF-kB is activated and signals survival	R-HSA-209560	6.537179e-01	0.185	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.537179e-01	0.185	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.537179e-01	0.185	0	0
Sodium/Calcium exchangers	R-HSA-425561	6.537179e-01	0.185	0	0
Amine ligand-binding receptors	R-HSA-375280	6.546909e-01	0.184	0	0
Signaling by FGFR2	R-HSA-5654738	6.579438e-01	0.182	0	0
Switching of origins to a post-replicative state	R-HSA-69052	6.597997e-01	0.181	0	0
MET promotes cell motility	R-HSA-8875878	6.598513e-01	0.181	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.598513e-01	0.181	0	0
Metabolism of non-coding RNA	R-HSA-194441	6.650957e-01	0.177	0	0
snRNP Assembly	R-HSA-191859	6.650957e-01	0.177	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.652667e-01	0.177	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	6.652667e-01	0.177	0	0
GAB1 signalosome	R-HSA-180292	6.652667e-01	0.177	0	0
Mismatch Repair	R-HSA-5358508	6.652667e-01	0.177	0	0
Tie2 Signaling	R-HSA-210993	6.652667e-01	0.177	0	0
Nephron development	R-HSA-9831926	6.652667e-01	0.177	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.669799e-01	0.176	0	0
DNA strand elongation	R-HSA-69190	6.669799e-01	0.176	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.688626e-01	0.175	0	0
Fanconi Anemia Pathway	R-HSA-6783310	6.737199e-01	0.172	0	0
Signaling by NOTCH4	R-HSA-9013694	6.750806e-01	0.171	1	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.772140e-01	0.169	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.772140e-01	0.169	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.800981e-01	0.167	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	6.800981e-01	0.167	0	0
Stabilization of p53	R-HSA-69541	6.800981e-01	0.167	0	0
IRAK1 recruits IKK complex	R-HSA-937039	6.879160e-01	0.162	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.879160e-01	0.162	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.879160e-01	0.162	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.879160e-01	0.162	0	0
Scavenging by Class F Receptors	R-HSA-3000484	6.879160e-01	0.162	0	0
p75NTR recruits signalling complexes	R-HSA-209543	6.879160e-01	0.162	0	0
MET activates RAS signaling	R-HSA-8851805	6.879160e-01	0.162	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.879160e-01	0.162	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.879160e-01	0.162	0	0
Pervasive developmental disorders	R-HSA-9005895	6.879160e-01	0.162	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.879160e-01	0.162	0	0
Estrogen biosynthesis	R-HSA-193144	6.879160e-01	0.162	0	0
Polymerase switching	R-HSA-69091	6.879160e-01	0.162	0	0
Leading Strand Synthesis	R-HSA-69109	6.879160e-01	0.162	0	0
OAS antiviral response	R-HSA-8983711	6.879160e-01	0.162	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.886971e-01	0.162	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.886971e-01	0.162	0	0
ISG15 antiviral mechanism	R-HSA-1169408	6.899540e-01	0.161	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.920805e-01	0.160	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.920805e-01	0.160	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.920805e-01	0.160	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.920805e-01	0.160	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.928319e-01	0.159	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.928319e-01	0.159	1	1
Other interleukin signaling	R-HSA-449836	6.928319e-01	0.159	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.932332e-01	0.159	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.956323e-01	0.158	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.962733e-01	0.157	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.962733e-01	0.157	0	0
PDE3B signalling	R-HSA-165160	6.962733e-01	0.157	0	0
PKB-mediated events	R-HSA-109703	6.962733e-01	0.157	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.962733e-01	0.157	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.962733e-01	0.157	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.962733e-01	0.157	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.962733e-01	0.157	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.962733e-01	0.157	0	0
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.962733e-01	0.157	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.962733e-01	0.157	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.962733e-01	0.157	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.962733e-01	0.157	0	0
Phosphorylation of Emi1	R-HSA-176417	6.962733e-01	0.157	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.962733e-01	0.157	0	0
Synthesis of PS	R-HSA-1483101	6.962733e-01	0.157	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	6.962733e-01	0.157	0	0
Formation of the Editosome	R-HSA-75094	6.962733e-01	0.157	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.962733e-01	0.157	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.962733e-01	0.157	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.962733e-01	0.157	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.962733e-01	0.157	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.962733e-01	0.157	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.962733e-01	0.157	0	0
TRAIL signaling	R-HSA-75158	6.962733e-01	0.157	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.978228e-01	0.156	0	0
Aquaporin-mediated transport	R-HSA-445717	6.978228e-01	0.156	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.995460e-01	0.155	0	0
Glycogen metabolism	R-HSA-8982491	6.995460e-01	0.155	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.995460e-01	0.155	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.007455e-01	0.154	0	0
Myogenesis	R-HSA-525793	7.007455e-01	0.154	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.007455e-01	0.154	0	0
Metalloprotease DUBs	R-HSA-5689901	7.007455e-01	0.154	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.007455e-01	0.154	0	0
Translation initiation complex formation	R-HSA-72649	7.031337e-01	0.153	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.038812e-01	0.153	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.038812e-01	0.153	0	0
Eukaryotic Translation Termination	R-HSA-72764	7.084300e-01	0.150	0	0
Miscellaneous transport and binding events	R-HSA-5223345	7.094300e-01	0.149	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.097591e-01	0.149	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	7.134064e-01	0.147	0	0
Maturation of spike protein	R-HSA-9694548	7.181832e-01	0.144	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.186475e-01	0.143	0	0
Signaling by NODAL	R-HSA-1181150	7.186475e-01	0.143	0	0
Creatine metabolism	R-HSA-71288	7.186475e-01	0.143	0	0
Signal transduction by L1	R-HSA-445144	7.186475e-01	0.143	0	0
Acetylcholine binding and downstream events	R-HSA-181431	7.192844e-01	0.143	0	0
Adenylate cyclase activating pathway	R-HSA-170660	7.192844e-01	0.143	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	7.192844e-01	0.143	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.192844e-01	0.143	0	0
FGFR1c ligand binding and activation	R-HSA-190373	7.192844e-01	0.143	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	7.192844e-01	0.143	0	0
Maturation of nucleoprotein	R-HSA-9683610	7.192844e-01	0.143	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.192844e-01	0.143	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.193792e-01	0.143	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.230108e-01	0.141	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.230136e-01	0.141	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.230136e-01	0.141	1	1
Adaptive Immune System	R-HSA-1280218	7.255761e-01	0.139	1	0
NGF-stimulated transcription	R-HSA-9031628	7.267464e-01	0.139	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.291724e-01	0.137	0	0
Dual Incision in GG-NER	R-HSA-5696400	7.291724e-01	0.137	0	0
Mitophagy	R-HSA-5205647	7.291724e-01	0.137	0	0
Signaling by NOTCH2	R-HSA-1980145	7.291724e-01	0.137	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	7.291724e-01	0.137	0	0
MHC class II antigen presentation	R-HSA-2132295	7.335732e-01	0.135	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	7.350209e-01	0.134	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.350209e-01	0.134	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.360038e-01	0.133	0	0
HIV Transcription Initiation	R-HSA-167161	7.360038e-01	0.133	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.360038e-01	0.133	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.360038e-01	0.133	0	0
STAT5 Activation	R-HSA-9645135	7.383171e-01	0.132	0	0
Erythropoietin activates STAT5	R-HSA-9027283	7.383171e-01	0.132	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.383171e-01	0.132	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.383171e-01	0.132	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.383171e-01	0.132	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.383171e-01	0.132	0	0
Lipid particle organization	R-HSA-8964572	7.383171e-01	0.132	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.427438e-01	0.129	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.427438e-01	0.129	0	0
Lagging Strand Synthesis	R-HSA-69186	7.427438e-01	0.129	0	0
Basigin interactions	R-HSA-210991	7.427438e-01	0.129	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.427438e-01	0.129	0	0
Gastrulation	R-HSA-9758941	7.457950e-01	0.127	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.464141e-01	0.127	0	0
Glucose metabolism	R-HSA-70326	7.466211e-01	0.127	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.479256e-01	0.126	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.479256e-01	0.126	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.479510e-01	0.126	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.479510e-01	0.126	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	7.479510e-01	0.126	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.479510e-01	0.126	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.479510e-01	0.126	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.479510e-01	0.126	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.479510e-01	0.126	0	0
Neutrophil degranulation	R-HSA-6798695	7.497308e-01	0.125	0	0
IRS-mediated signalling	R-HSA-112399	7.500548e-01	0.125	0	0
Regulation of CDH1 Function	R-HSA-9764561	7.500548e-01	0.125	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.505996e-01	0.125	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	7.570834e-01	0.121	0	0
PKR-mediated signaling	R-HSA-9833482	7.579076e-01	0.120	0	0
Regulation of RAS by GAPs	R-HSA-5658442	7.586316e-01	0.120	0	0
PI3K Cascade	R-HSA-109704	7.586316e-01	0.120	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.602997e-01	0.119	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	7.637268e-01	0.117	0	0
mRNA Capping	R-HSA-72086	7.638007e-01	0.117	0	0
Dual incision in TC-NER	R-HSA-6782135	7.644802e-01	0.117	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.644802e-01	0.117	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.651659e-01	0.116	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.651659e-01	0.116	0	0
Signaling by PDGFR in disease	R-HSA-9671555	7.651659e-01	0.116	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.656977e-01	0.116	0	0
GPVI-mediated activation cascade	R-HSA-114604	7.656977e-01	0.116	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.691977e-01	0.114	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	7.735311e-01	0.112	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.740494e-01	0.111	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	7.740627e-01	0.111	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	7.740627e-01	0.111	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.740627e-01	0.111	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	7.740627e-01	0.111	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.740627e-01	0.111	0	0
p38MAPK events	R-HSA-171007	7.740627e-01	0.111	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.745431e-01	0.111	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.745431e-01	0.111	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.745431e-01	0.111	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	7.745431e-01	0.111	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.745431e-01	0.111	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.745431e-01	0.111	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.745431e-01	0.111	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.745431e-01	0.111	0	0
VLDL clearance	R-HSA-8964046	7.745431e-01	0.111	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	7.745431e-01	0.111	0	0
Glycoprotein hormones	R-HSA-209822	7.745431e-01	0.111	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.745431e-01	0.111	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.745431e-01	0.111	0	0
Selenocysteine synthesis	R-HSA-2408557	7.780713e-01	0.109	0	0
Extension of Telomeres	R-HSA-180786	7.782991e-01	0.109	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.804627e-01	0.108	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.823632e-01	0.107	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.823632e-01	0.107	0	0
Signaling by KIT in disease	R-HSA-9669938	7.859706e-01	0.105	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.859706e-01	0.105	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.859706e-01	0.105	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.859706e-01	0.105	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.859706e-01	0.105	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.859706e-01	0.105	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.859706e-01	0.105	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.859706e-01	0.105	0	0
Orc1 removal from chromatin	R-HSA-68949	7.877420e-01	0.104	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.877420e-01	0.104	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.877420e-01	0.104	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.883410e-01	0.103	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.883410e-01	0.103	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.901301e-01	0.102	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.902076e-01	0.102	1	1
GABA receptor activation	R-HSA-977443	7.915158e-01	0.102	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.953100e-01	0.099	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.977774e-01	0.098	0	0
Killing mechanisms	R-HSA-9664420	7.977774e-01	0.098	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.977774e-01	0.098	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.977774e-01	0.098	1	1
Regulation of BACH1 activity	R-HSA-9708530	7.977774e-01	0.098	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.977774e-01	0.098	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.977774e-01	0.098	0	0
Activation of SMO	R-HSA-5635838	7.977774e-01	0.098	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.977774e-01	0.098	0	0
Viral mRNA Translation	R-HSA-192823	7.985077e-01	0.098	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.991776e-01	0.097	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.997463e-01	0.097	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.997463e-01	0.097	0	0
UCH proteinases	R-HSA-5689603	7.999548e-01	0.097	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.012730e-01	0.096	1	1
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.012730e-01	0.096	0	0
COPI-mediated anterograde transport	R-HSA-6807878	8.033625e-01	0.095	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.052232e-01	0.094	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.052232e-01	0.094	0	0
Formation of the ureteric bud	R-HSA-9830674	8.052232e-01	0.094	0	0
Growth hormone receptor signaling	R-HSA-982772	8.052232e-01	0.094	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.057559e-01	0.094	0	0
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	8.057559e-01	0.094	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	8.057559e-01	0.094	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.057559e-01	0.094	0	0
Interleukin-9 signaling	R-HSA-8985947	8.057559e-01	0.094	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	8.057559e-01	0.094	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.057559e-01	0.094	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.057559e-01	0.094	0	0
Cap-dependent Translation Initiation	R-HSA-72737	8.087468e-01	0.092	0	0
Eukaryotic Translation Initiation	R-HSA-72613	8.087468e-01	0.092	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.161716e-01	0.088	0	0
Heme signaling	R-HSA-9707616	8.161716e-01	0.088	0	0
G alpha (s) signalling events	R-HSA-418555	8.164767e-01	0.088	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.175618e-01	0.087	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.192582e-01	0.087	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.192582e-01	0.087	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.192582e-01	0.087	0	0
Passive transport by Aquaporins	R-HSA-432047	8.192582e-01	0.087	0	0
Synthesis of PG	R-HSA-1483148	8.192582e-01	0.087	0	0
Signaling by FGFR	R-HSA-190236	8.226657e-01	0.085	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.229955e-01	0.085	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.229955e-01	0.085	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.260541e-01	0.083	0	0
Adipogenesis	R-HSA-9843745	8.264481e-01	0.083	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.273232e-01	0.082	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.273232e-01	0.082	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.295752e-01	0.081	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	8.326491e-01	0.080	0	0
Interleukin-21 signaling	R-HSA-9020958	8.326491e-01	0.080	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.326491e-01	0.080	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.326491e-01	0.080	0	0
p75NTR regulates axonogenesis	R-HSA-193697	8.326491e-01	0.080	0	0
Regulation of signaling by NODAL	R-HSA-1433617	8.326491e-01	0.080	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.326491e-01	0.080	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.326491e-01	0.080	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	8.326491e-01	0.080	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.326491e-01	0.080	0	0
Hemostasis	R-HSA-109582	8.344608e-01	0.079	1	0
Cellular response to chemical stress	R-HSA-9711123	8.375284e-01	0.077	1	0
Intraflagellar transport	R-HSA-5620924	8.383757e-01	0.077	0	0
Metal ion SLC transporters	R-HSA-425410	8.383757e-01	0.077	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	8.386689e-01	0.076	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.386689e-01	0.076	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.386689e-01	0.076	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.386689e-01	0.076	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.393636e-01	0.076	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.393636e-01	0.076	0	0
G protein gated Potassium channels	R-HSA-1296059	8.393636e-01	0.076	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.393636e-01	0.076	0	0
Hyaluronan degradation	R-HSA-2160916	8.393636e-01	0.076	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.404873e-01	0.075	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.404873e-01	0.075	0	0
Synthesis of DNA	R-HSA-69239	8.435997e-01	0.074	0	0
Vesicle-mediated transport	R-HSA-5653656	8.443996e-01	0.073	1	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.452211e-01	0.073	0	0
Platelet degranulation	R-HSA-114608	8.456648e-01	0.073	0	0
GPCR downstream signalling	R-HSA-388396	8.479022e-01	0.072	1	0
DNA Damage Bypass	R-HSA-73893	8.499825e-01	0.071	0	0
Degradation of CDH1	R-HSA-9766229	8.499825e-01	0.071	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.528142e-01	0.069	0	0
Intra-Golgi traffic	R-HSA-6811438	8.528142e-01	0.069	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	8.544057e-01	0.068	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.544057e-01	0.068	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.558202e-01	0.068	0	0
2-LTR circle formation	R-HSA-164843	8.558202e-01	0.068	0	0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.558202e-01	0.068	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.558202e-01	0.068	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.558202e-01	0.068	0	0
Formation of intermediate mesoderm	R-HSA-9761174	8.558202e-01	0.068	0	0
Arachidonate production from DAG	R-HSA-426048	8.558202e-01	0.068	0	0
Pexophagy	R-HSA-9664873	8.558202e-01	0.068	0	0
Maturation of spike protein	R-HSA-9683686	8.558202e-01	0.068	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.558202e-01	0.068	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.558202e-01	0.068	0	0
Sperm Motility And Taxes	R-HSA-1300642	8.558202e-01	0.068	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	8.558202e-01	0.068	0	0
Peptide hormone biosynthesis	R-HSA-209952	8.558202e-01	0.068	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.558202e-01	0.068	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.561710e-01	0.067	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.561710e-01	0.067	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.561710e-01	0.067	0	0
Platelet sensitization by LDL	R-HSA-432142	8.561710e-01	0.067	0	0
Hyaluronan metabolism	R-HSA-2142845	8.583057e-01	0.066	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.608987e-01	0.065	0	0
Activation of GABAB receptors	R-HSA-991365	8.643375e-01	0.063	0	0
GABA B receptor activation	R-HSA-977444	8.643375e-01	0.063	0	0
Parasitic Infection Pathways	R-HSA-9824443	8.667144e-01	0.062	0	0
Leishmania infection	R-HSA-9658195	8.667144e-01	0.062	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.682014e-01	0.061	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	8.689539e-01	0.061	0	0
Triglyceride metabolism	R-HSA-8979227	8.689539e-01	0.061	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.693839e-01	0.061	0	0
Cellular response to starvation	R-HSA-9711097	8.712355e-01	0.060	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.719208e-01	0.060	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	8.719208e-01	0.060	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.719208e-01	0.060	0	0
Maturation of nucleoprotein	R-HSA-9694631	8.719208e-01	0.060	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.757843e-01	0.058	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.757843e-01	0.058	0	0
vRNA Synthesis	R-HSA-192814	8.757843e-01	0.058	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.757843e-01	0.058	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.757843e-01	0.058	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.757843e-01	0.058	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.757843e-01	0.058	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.757843e-01	0.058	0	0
Suppression of apoptosis	R-HSA-9635465	8.757843e-01	0.058	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.757843e-01	0.058	1	1
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.767479e-01	0.057	0	0
HCMV Early Events	R-HSA-9609690	8.793890e-01	0.056	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.807623e-01	0.055	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.807623e-01	0.055	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.808298e-01	0.055	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.808298e-01	0.055	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.816575e-01	0.055	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	8.816575e-01	0.055	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.816575e-01	0.055	0	0
IRE1alpha activates chaperones	R-HSA-381070	8.842529e-01	0.053	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.851130e-01	0.053	0	0
DAP12 interactions	R-HSA-2172127	8.851130e-01	0.053	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.860678e-01	0.053	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.860678e-01	0.053	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	8.860678e-01	0.053	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.867968e-01	0.052	0	0
Signaling by Insulin receptor	R-HSA-74752	8.912093e-01	0.050	0	0
Degradation of DVL	R-HSA-4641258	8.920252e-01	0.050	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	8.920252e-01	0.050	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.923689e-01	0.049	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.929850e-01	0.049	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.929850e-01	0.049	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.929850e-01	0.049	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.929850e-01	0.049	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.929850e-01	0.049	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.929850e-01	0.049	0	0
Integration of provirus	R-HSA-162592	8.929850e-01	0.049	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.929850e-01	0.049	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.944365e-01	0.048	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.944365e-01	0.048	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.944365e-01	0.048	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.944365e-01	0.048	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.949256e-01	0.048	0	0
Signaling by PDGF	R-HSA-186797	8.949256e-01	0.048	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	8.980646e-01	0.047	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.987539e-01	0.046	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.987539e-01	0.046	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.987539e-01	0.046	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.001017e-01	0.046	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.025550e-01	0.045	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.030983e-01	0.044	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.055450e-01	0.043	0	0
Signaling by MET	R-HSA-6806834	9.055450e-01	0.043	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	9.078047e-01	0.042	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	9.078047e-01	0.042	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.078047e-01	0.042	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	9.078047e-01	0.042	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	9.078047e-01	0.042	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.078047e-01	0.042	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	9.078047e-01	0.042	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.101123e-01	0.041	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.101123e-01	0.041	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.101123e-01	0.041	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.103931e-01	0.041	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.111341e-01	0.040	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.118861e-01	0.040	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.124816e-01	0.040	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.124816e-01	0.040	0	0
Cargo concentration in the ER	R-HSA-5694530	9.124816e-01	0.040	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.124816e-01	0.040	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.124816e-01	0.040	0	0
Cellular response to hypoxia	R-HSA-1234174	9.164033e-01	0.038	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.184905e-01	0.037	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.186109e-01	0.037	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.202674e-01	0.036	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.202674e-01	0.036	0	0
FGFR2c ligand binding and activation	R-HSA-190375	9.205729e-01	0.036	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.205729e-01	0.036	0	0
FGFR4 ligand binding and activation	R-HSA-190322	9.205729e-01	0.036	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.205729e-01	0.036	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.205729e-01	0.036	0	0
Chylomicron remodeling	R-HSA-8963901	9.205729e-01	0.036	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	9.205729e-01	0.036	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.205729e-01	0.036	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	9.205729e-01	0.036	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	9.205729e-01	0.036	0	0
Processing of SMDT1	R-HSA-8949664	9.205729e-01	0.036	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.205729e-01	0.036	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	9.205729e-01	0.036	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.213412e-01	0.036	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	9.233850e-01	0.035	1	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.259262e-01	0.033	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.259262e-01	0.033	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.265479e-01	0.033	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.291158e-01	0.032	0	0
Carnitine shuttle	R-HSA-200425	9.293345e-01	0.032	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.293345e-01	0.032	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.293345e-01	0.032	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.293345e-01	0.032	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.306325e-01	0.031	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.315734e-01	0.031	0	0
Prolactin receptor signaling	R-HSA-1170546	9.315734e-01	0.031	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.315734e-01	0.031	0	0
CRMPs in Sema3A signaling	R-HSA-399956	9.315734e-01	0.031	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	9.315734e-01	0.031	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.315734e-01	0.031	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.315734e-01	0.031	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.315734e-01	0.031	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.315734e-01	0.031	0	0
Glycerophospholipid catabolism	R-HSA-6814848	9.315734e-01	0.031	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.315734e-01	0.031	0	0
Non-canonical inflammasome activation	R-HSA-9686114	9.315734e-01	0.031	0	0
Ciprofloxacin ADME	R-HSA-9793528	9.315734e-01	0.031	0	0
P2Y receptors	R-HSA-417957	9.315734e-01	0.031	0	0
Zinc transporters	R-HSA-435354	9.315734e-01	0.031	0	0
Translation of Structural Proteins	R-HSA-9694635	9.360425e-01	0.029	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.362947e-01	0.029	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.362947e-01	0.029	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.374202e-01	0.028	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.379288e-01	0.028	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.383351e-01	0.028	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.389902e-01	0.027	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.399234e-01	0.027	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.408774e-01	0.026	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.410509e-01	0.026	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.410509e-01	0.026	0	0
Translesion synthesis by REV1	R-HSA-110312	9.410509e-01	0.026	0	0
Signaling by Activin	R-HSA-1502540	9.410509e-01	0.026	0	0
Biotin transport and metabolism	R-HSA-196780	9.410509e-01	0.026	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.410509e-01	0.026	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.410509e-01	0.026	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.410509e-01	0.026	0	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.410509e-01	0.026	0	0
Other semaphorin interactions	R-HSA-416700	9.410509e-01	0.026	0	0
DNA Damage Reversal	R-HSA-73942	9.410509e-01	0.026	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.427964e-01	0.026	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.427964e-01	0.026	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.446224e-01	0.025	0	0
Laminin interactions	R-HSA-3000157	9.446224e-01	0.025	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.446224e-01	0.025	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.473571e-01	0.023	0	0
Mitochondrial protein import	R-HSA-1268020	9.477126e-01	0.023	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.481117e-01	0.023	0	0
Regulation of Apoptosis	R-HSA-169911	9.486775e-01	0.023	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.486775e-01	0.023	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.486775e-01	0.023	0	0
Translesion synthesis by POLI	R-HSA-5656121	9.492162e-01	0.023	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	9.492162e-01	0.023	0	0
Fructose catabolism	R-HSA-70350	9.492162e-01	0.023	0	0
Atorvastatin ADME	R-HSA-9754706	9.492162e-01	0.023	0	0
Ribosome-associated quality control	R-HSA-9948299	9.504848e-01	0.022	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.510306e-01	0.022	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.510306e-01	0.022	0	0
Abacavir ADME	R-HSA-2161522	9.510306e-01	0.022	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.524241e-01	0.021	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.526991e-01	0.021	0	0
Glycosphingolipid transport	R-HSA-9845576	9.539910e-01	0.020	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	9.542414e-01	0.020	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.546855e-01	0.020	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.558821e-01	0.020	0	0
Immune System	R-HSA-168256	9.560193e-01	0.020	1	0
Inositol phosphate metabolism	R-HSA-1483249	9.561299e-01	0.019	0	0
Leishmania phagocytosis	R-HSA-9664417	9.561896e-01	0.019	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.561896e-01	0.019	0	0
Parasite infection	R-HSA-9664407	9.561896e-01	0.019	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	9.562509e-01	0.019	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.562509e-01	0.019	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.562509e-01	0.019	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.562509e-01	0.019	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.562509e-01	0.019	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.562509e-01	0.019	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.562509e-01	0.019	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.562509e-01	0.019	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.562509e-01	0.019	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.567265e-01	0.019	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.567265e-01	0.019	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.567265e-01	0.019	0	0
Signaling by BMP	R-HSA-201451	9.567265e-01	0.019	0	0
Insulin processing	R-HSA-264876	9.567265e-01	0.019	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.569142e-01	0.019	0	0
G alpha (z) signalling events	R-HSA-418597	9.569142e-01	0.019	0	0
Downstream TCR signaling	R-HSA-202424	9.576940e-01	0.019	0	0
Neurotransmitter release cycle	R-HSA-112310	9.576940e-01	0.019	0	0
G alpha (q) signalling events	R-HSA-416476	9.578907e-01	0.019	0	0
Influenza Infection	R-HSA-168255	9.581201e-01	0.019	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.587864e-01	0.018	0	0
Degradation of AXIN	R-HSA-4641257	9.587864e-01	0.018	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.590278e-01	0.018	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.600463e-01	0.018	0	0
HIV Life Cycle	R-HSA-162587	9.606527e-01	0.017	0	0
Insulin receptor recycling	R-HSA-77387	9.617845e-01	0.017	0	0
Pyrimidine salvage	R-HSA-73614	9.617845e-01	0.017	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.623115e-01	0.017	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.623115e-01	0.017	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.623115e-01	0.017	0	0
Glycogen storage diseases	R-HSA-3229121	9.623115e-01	0.017	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.623115e-01	0.017	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	9.623115e-01	0.017	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.623115e-01	0.017	0	0
Catecholamine biosynthesis	R-HSA-209905	9.623115e-01	0.017	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.623115e-01	0.017	0	0
Choline catabolism	R-HSA-6798163	9.623115e-01	0.017	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	9.636703e-01	0.016	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.662719e-01	0.015	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.662719e-01	0.015	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.662719e-01	0.015	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.663860e-01	0.015	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.675328e-01	0.014	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.675328e-01	0.014	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	9.675328e-01	0.014	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.675328e-01	0.014	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	9.675328e-01	0.014	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.675328e-01	0.014	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.675328e-01	0.014	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.675328e-01	0.014	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.687031e-01	0.014	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.698486e-01	0.013	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.702498e-01	0.013	0	0
Neurotransmitter clearance	R-HSA-112311	9.702498e-01	0.013	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.702498e-01	0.013	1	1
Amino acid transport across the plasma membrane	R-HSA-352230	9.705550e-01	0.013	0	0
PCP/CE pathway	R-HSA-4086400	9.713337e-01	0.013	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.720310e-01	0.012	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.720310e-01	0.012	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.720310e-01	0.012	0	0
Regulation of signaling by CBL	R-HSA-912631	9.720310e-01	0.012	0	0
Diseases of hemostasis	R-HSA-9671793	9.720310e-01	0.012	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.720310e-01	0.012	0	0
PPARA activates gene expression	R-HSA-1989781	9.731444e-01	0.012	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.734879e-01	0.012	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.736548e-01	0.012	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.737732e-01	0.012	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.737732e-01	0.012	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.737732e-01	0.012	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.743815e-01	0.011	0	0
Signaling by GPCR	R-HSA-372790	9.743983e-01	0.011	1	0
HIV Infection	R-HSA-162906	9.747145e-01	0.011	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.755097e-01	0.011	0	0
The phototransduction cascade	R-HSA-2514856	9.755097e-01	0.011	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.757593e-01	0.011	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.758766e-01	0.011	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.759062e-01	0.011	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.759062e-01	0.011	0	0
Glycogen synthesis	R-HSA-3322077	9.759062e-01	0.011	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.759062e-01	0.011	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.759062e-01	0.011	0	0
Negative regulation of MET activity	R-HSA-6807004	9.759062e-01	0.011	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.763841e-01	0.010	0	0
HCMV Late Events	R-HSA-9610379	9.763841e-01	0.010	0	0
Translation of Structural Proteins	R-HSA-9683701	9.764827e-01	0.010	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.768916e-01	0.010	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.790202e-01	0.009	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.792447e-01	0.009	0	0
G-protein activation	R-HSA-202040	9.792447e-01	0.009	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.792447e-01	0.009	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.792447e-01	0.009	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.792447e-01	0.009	0	0
Phenylalanine metabolism	R-HSA-8964208	9.792447e-01	0.009	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.792447e-01	0.009	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.792447e-01	0.009	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.792447e-01	0.009	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.792447e-01	0.009	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.795477e-01	0.009	1	0
IPs transport between nucleus and cytosol	R-HSA-1855170	9.796496e-01	0.009	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.796496e-01	0.009	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.812952e-01	0.008	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.812952e-01	0.008	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.820871e-01	0.008	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.820871e-01	0.008	0	0
Heme degradation	R-HSA-189483	9.820871e-01	0.008	0	0
Attachment and Entry	R-HSA-9694614	9.821208e-01	0.008	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.821208e-01	0.008	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.821208e-01	0.008	0	0
Serine metabolism	R-HSA-977347	9.821208e-01	0.008	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.821208e-01	0.008	0	0
HCMV Infection	R-HSA-9609646	9.827932e-01	0.008	0	0
Gap junction trafficking	R-HSA-190828	9.833333e-01	0.007	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.838867e-01	0.007	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.839888e-01	0.007	0	0
Protein folding	R-HSA-391251	9.841087e-01	0.007	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.841087e-01	0.007	0	0
eNOS activation	R-HSA-203615	9.842401e-01	0.007	1	1
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.842401e-01	0.007	0	0
Nuclear import of Rev protein	R-HSA-180746	9.842401e-01	0.007	0	0
Signal amplification	R-HSA-392518	9.842401e-01	0.007	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.842401e-01	0.007	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.845985e-01	0.007	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.845985e-01	0.007	0	0
Fructose metabolism	R-HSA-5652084	9.845985e-01	0.007	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.845985e-01	0.007	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.845985e-01	0.007	0	0
LDL clearance	R-HSA-8964038	9.845985e-01	0.007	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.845985e-01	0.007	0	0
Somitogenesis	R-HSA-9824272	9.851577e-01	0.006	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.852579e-01	0.006	0	0
Circadian clock	R-HSA-9909396	9.855157e-01	0.006	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.856004e-01	0.006	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	9.861405e-01	0.006	0	0
PERK regulates gene expression	R-HSA-381042	9.861405e-01	0.006	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.861405e-01	0.006	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.861405e-01	0.006	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.866606e-01	0.006	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.867329e-01	0.006	0	0
Biosynthesis of maresins	R-HSA-9018682	9.867329e-01	0.006	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.867329e-01	0.006	0	0
Phospholipid metabolism	R-HSA-1483257	9.868816e-01	0.006	0	0
ABC transporter disorders	R-HSA-5619084	9.879953e-01	0.005	0	0
Interleukin-10 signaling	R-HSA-6783783	9.879953e-01	0.005	0	0
Integrin cell surface interactions	R-HSA-216083	9.879953e-01	0.005	0	0
rRNA processing	R-HSA-72312	9.880557e-01	0.005	0	0
Interferon Signaling	R-HSA-913531	9.882463e-01	0.005	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.882485e-01	0.005	0	0
Interferon gamma signaling	R-HSA-877300	9.883565e-01	0.005	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.884043e-01	0.005	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.885716e-01	0.005	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.885716e-01	0.005	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.885716e-01	0.005	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.885716e-01	0.005	0	0
Complex III assembly	R-HSA-9865881	9.885716e-01	0.005	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.891062e-01	0.005	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.892952e-01	0.005	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.892952e-01	0.005	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.892952e-01	0.005	0	0
NCAM1 interactions	R-HSA-419037	9.892952e-01	0.005	0	0
Collagen chain trimerization	R-HSA-8948216	9.892952e-01	0.005	0	0
RSV-host interactions	R-HSA-9833110	9.894384e-01	0.005	0	0
SARS-CoV Infections	R-HSA-9679506	9.894423e-01	0.005	1	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.896029e-01	0.005	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.901556e-01	0.004	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.901556e-01	0.004	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.901556e-01	0.004	0	0
Fertilization	R-HSA-1187000	9.901556e-01	0.004	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.901556e-01	0.004	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.901556e-01	0.004	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.902004e-01	0.004	0	0
ER-Phagosome pathway	R-HSA-1236974	9.903044e-01	0.004	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.905977e-01	0.004	1	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.905977e-01	0.004	0	0
tRNA Aminoacylation	R-HSA-379724	9.906825e-01	0.004	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.907149e-01	0.004	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.915202e-01	0.004	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.915202e-01	0.004	0	0
Urea cycle	R-HSA-70635	9.915202e-01	0.004	0	0
Sphingolipid catabolism	R-HSA-9845614	9.915202e-01	0.004	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.915202e-01	0.004	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.916544e-01	0.004	0	0
Pentose phosphate pathway	R-HSA-71336	9.917449e-01	0.004	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.917449e-01	0.004	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.917449e-01	0.004	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.917449e-01	0.004	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.921316e-01	0.003	0	0
Host Interactions of HIV factors	R-HSA-162909	9.921817e-01	0.003	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.925464e-01	0.003	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.926512e-01	0.003	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.926778e-01	0.003	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.926956e-01	0.003	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.926956e-01	0.003	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.926956e-01	0.003	0	0
Triglyceride biosynthesis	R-HSA-75109	9.926956e-01	0.003	0	0
Synthesis of PE	R-HSA-1483213	9.926956e-01	0.003	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.927548e-01	0.003	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.927548e-01	0.003	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	9.927548e-01	0.003	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.927548e-01	0.003	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.933598e-01	0.003	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.936434e-01	0.003	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.936434e-01	0.003	0	0
Prednisone ADME	R-HSA-9757110	9.937082e-01	0.003	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.937082e-01	0.003	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.942593e-01	0.003	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.944250e-01	0.002	0	0
Collagen formation	R-HSA-1474290	9.945207e-01	0.002	0	0
Thyroxine biosynthesis	R-HSA-209968	9.945805e-01	0.002	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.945805e-01	0.002	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.945805e-01	0.002	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.945805e-01	0.002	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.951121e-01	0.002	0	0
Neddylation	R-HSA-8951664	9.951219e-01	0.002	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.955498e-01	0.002	0	0
Defensins	R-HSA-1461973	9.957158e-01	0.002	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.957158e-01	0.002	0	0
Cholesterol biosynthesis	R-HSA-191273	9.957758e-01	0.002	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.959791e-01	0.002	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.959791e-01	0.002	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.959878e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.961920e-01	0.002	0	0
Proteasome assembly	R-HSA-9907900	9.962462e-01	0.002	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.962462e-01	0.002	0	0
Surfactant metabolism	R-HSA-5683826	9.962462e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.964470e-01	0.002	0	0
HS-GAG degradation	R-HSA-2024096	9.965366e-01	0.002	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.967119e-01	0.001	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.969689e-01	0.001	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.970169e-01	0.001	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.971206e-01	0.001	0	0
Peroxisomal protein import	R-HSA-9033241	9.972170e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.972974e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.972974e-01	0.001	1	0
Signaling by Retinoic Acid	R-HSA-5362517	9.975384e-01	0.001	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.975913e-01	0.001	0	0
Protein localization	R-HSA-9609507	9.976645e-01	0.001	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.977869e-01	0.001	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.977869e-01	0.001	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.977869e-01	0.001	0	0
Gap junction assembly	R-HSA-190861	9.977869e-01	0.001	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.977869e-01	0.001	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.977869e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.978234e-01	0.001	0	0
Nucleotide salvage	R-HSA-8956321	9.978234e-01	0.001	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.980697e-01	0.001	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.980889e-01	0.001	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.980938e-01	0.001	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.980938e-01	0.001	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.980938e-01	0.001	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.982987e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.982987e-01	0.001	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.983582e-01	0.001	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.983582e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.985233e-01	0.001	0	0
Formation of the cornified envelope	R-HSA-6809371	9.985756e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.985851e-01	0.001	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.985859e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.985859e-01	0.001	0	0
Lysine catabolism	R-HSA-71064	9.985859e-01	0.001	0	0
G alpha (i) signalling events	R-HSA-418594	9.986067e-01	0.001	0	0
Innate Immune System	R-HSA-168249	9.986393e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.987821e-01	0.001	0	0
Elastic fibre formation	R-HSA-1566948	9.987821e-01	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.988714e-01	0.000	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.989510e-01	0.000	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.989510e-01	0.000	0	0
RAS processing	R-HSA-9648002	9.989510e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.989670e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.989670e-01	0.000	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.990793e-01	0.000	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.990966e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.991275e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.991275e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.991950e-01	0.000	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.992219e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.992694e-01	0.000	0	0
Heme biosynthesis	R-HSA-189451	9.993299e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.993754e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.994496e-01	0.000	0	0
Pyrimidine catabolism	R-HSA-73621	9.995029e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.995626e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.995686e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.995686e-01	0.000	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.995719e-01	0.000	0	0
Methylation	R-HSA-156581	9.995719e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.995896e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.996265e-01	0.000	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.996313e-01	0.000	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.996313e-01	0.000	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.996669e-01	0.000	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.996825e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.997266e-01	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.997645e-01	0.000	0	0
Gluconeogenesis	R-HSA-70263	9.997645e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.998257e-01	0.000	0	0
SLC transporter disorders	R-HSA-5619102	9.998924e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.999000e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999031e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.999031e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999051e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.999160e-01	0.000	1	0
Paracetamol ADME	R-HSA-9753281	9.999173e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999265e-01	0.000	0	0
Digestion	R-HSA-8935690	9.999288e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.999387e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999416e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999545e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.999608e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999613e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999680e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999691e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.999750e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999750e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999785e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999815e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999834e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.999855e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999863e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999872e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999873e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999873e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.999882e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999888e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999895e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.999909e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999921e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999921e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999923e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999934e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.999974e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999974e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999974e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999978e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999983e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999988e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999989e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999994e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.999995e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999996e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999996e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999997e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999998e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999998e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999998e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999999e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999999e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999999e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	1	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	1	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	1	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	1	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.603975e-10	9.795	1	1
Attenuation phase	R-HSA-3371568	9.751566e-10	9.011	0	0
HSF1-dependent transactivation	R-HSA-3371571	4.040258e-09	8.394	0	0
Cell Cycle	R-HSA-1640170	1.983064e-08	7.703	1	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.207971e-08	7.656	0	0
Cellular response to heat stress	R-HSA-3371556	7.308408e-08	7.136	0	0
NRAGE signals death through JNK	R-HSA-193648	7.755789e-08	7.110	0	0
Cellular Senescence	R-HSA-2559583	8.460686e-08	7.073	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.045765e-07	6.981	1	0
Cell Cycle Checkpoints	R-HSA-69620	3.465260e-07	6.460	0	0
HSF1 activation	R-HSA-3371511	4.538924e-07	6.343	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.911019e-07	6.309	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.193255e-07	6.285	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	7.380410e-07	6.132	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.544004e-06	5.811	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.567970e-06	5.805	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.518960e-06	5.818	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.079349e-06	5.682	1	1
G2/M DNA damage checkpoint	R-HSA-69473	2.038579e-06	5.691	0	0
Chromatin organization	R-HSA-4839726	2.349462e-06	5.629	0	0
Mitotic Prophase	R-HSA-68875	3.052918e-06	5.515	0	0
Cell Cycle, Mitotic	R-HSA-69278	3.179203e-06	5.498	1	0
Signal Transduction	R-HSA-162582	3.573914e-06	5.447	1	0
Estrogen-dependent gene expression	R-HSA-9018519	3.710510e-06	5.431	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.690647e-06	5.329	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.006805e-06	5.300	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.763225e-06	5.110	0	0
Chromatin modifying enzymes	R-HSA-3247509	7.938011e-06	5.100	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.839227e-06	5.054	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.142865e-05	4.942	0	0
M Phase	R-HSA-68886	1.230169e-05	4.910	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.613514e-05	4.792	0	0
Meiotic synapsis	R-HSA-1221632	1.843004e-05	4.734	0	0
Packaging Of Telomere Ends	R-HSA-171306	2.194058e-05	4.659	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.210034e-05	4.656	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	2.194058e-05	4.659	0	0
Death Receptor Signaling	R-HSA-73887	2.104866e-05	4.677	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.299999e-05	4.638	0	0
G2/M Checkpoints	R-HSA-69481	2.418948e-05	4.616	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.575808e-05	4.589	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.904758e-05	4.537	1	1
PRC2 methylates histones and DNA	R-HSA-212300	2.835711e-05	4.547	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.810888e-05	4.551	0	0
DNA methylation	R-HSA-5334118	4.107785e-05	4.386	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.107785e-05	4.386	0	0
ESR-mediated signaling	R-HSA-8939211	4.154948e-05	4.381	1	0
DNA Double Strand Break Response	R-HSA-5693606	3.784512e-05	4.422	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.104985e-05	4.387	0	0
Axon guidance	R-HSA-422475	4.105406e-05	4.387	0	0
Apoptotic execution phase	R-HSA-75153	3.827319e-05	4.417	0	0
mRNA 3'-end processing	R-HSA-72187	4.647153e-05	4.333	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.489027e-05	4.188	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.601096e-05	4.119	1	0
Diseases of programmed cell death	R-HSA-9645723	9.031530e-05	4.044	0	0
Nucleosome assembly	R-HSA-774815	9.776838e-05	4.010	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.776838e-05	4.010	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	9.741250e-05	4.011	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	9.481869e-05	4.023	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.033190e-04	3.986	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.127404e-04	3.948	0	0
Apoptosis	R-HSA-109581	1.136680e-04	3.944	1	0
Cleavage of the damaged purine	R-HSA-110331	1.285705e-04	3.891	0	0
Nervous system development	R-HSA-9675108	1.509270e-04	3.821	0	0
Depurination	R-HSA-73927	1.632398e-04	3.787	0	0
Cellular responses to stimuli	R-HSA-8953897	1.571733e-04	3.804	1	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.712477e-04	3.766	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.789458e-04	3.747	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.089729e-04	3.680	0	0
Intracellular signaling by second messengers	R-HSA-9006925	2.231343e-04	3.651	1	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.259676e-04	3.646	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.265623e-04	3.645	0	0
Cell junction organization	R-HSA-446728	2.391696e-04	3.621	0	0
Cellular responses to stress	R-HSA-2262752	2.429267e-04	3.615	1	0
HATs acetylate histones	R-HSA-3214847	2.504105e-04	3.601	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.574892e-04	3.589	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	2.504105e-04	3.601	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.821118e-04	3.550	0	0
Meiosis	R-HSA-1500620	2.992205e-04	3.524	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.200931e-04	3.495	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.200931e-04	3.495	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	4.188621e-04	3.378	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.715375e-04	3.326	0	0
Assembly of the pre-replicative complex	R-HSA-68867	5.153742e-04	3.288	0	0
Signaling by ROBO receptors	R-HSA-376176	4.888169e-04	3.311	0	0
Defective pyroptosis	R-HSA-9710421	5.922089e-04	3.228	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	6.049751e-04	3.218	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.276009e-04	3.202	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.210682e-04	3.207	0	0
Programmed Cell Death	R-HSA-5357801	6.329933e-04	3.199	1	0
HDACs deacetylate histones	R-HSA-3214815	6.872610e-04	3.163	0	0
Activation of BH3-only proteins	R-HSA-114452	7.068726e-04	3.151	1	0
Signaling by Hippo	R-HSA-2028269	7.948222e-04	3.100	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.365812e-04	3.077	0	0
Meiotic recombination	R-HSA-912446	9.239292e-04	3.034	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.174163e-03	2.930	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.174163e-03	2.930	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.275490e-03	2.894	1	1
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.276549e-03	2.894	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.275490e-03	2.894	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.275490e-03	2.894	1	1
Cell-Cell communication	R-HSA-1500931	1.271763e-03	2.896	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.311272e-03	2.882	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	1.418367e-03	2.848	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.418367e-03	2.848	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.372376e-03	2.863	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.372376e-03	2.863	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	1.397582e-03	2.855	0	0
Depyrimidination	R-HSA-73928	1.397582e-03	2.855	0	0
Rap1 signalling	R-HSA-392517	1.440533e-03	2.841	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.508557e-03	2.821	0	0
Gene Silencing by RNA	R-HSA-211000	1.646903e-03	2.783	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.759940e-03	2.755	1	0
Membrane Trafficking	R-HSA-199991	1.842645e-03	2.735	1	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.080296e-03	2.682	1	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.168976e-03	2.664	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.345423e-03	2.630	1	0
DAG and IP3 signaling	R-HSA-1489509	2.361180e-03	2.627	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.456741e-03	2.610	0	0
PKMTs methylate histone lysines	R-HSA-3214841	2.691354e-03	2.570	0	0
FLT3 Signaling	R-HSA-9607240	2.691354e-03	2.570	1	1
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.788159e-03	2.555	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.815514e-03	2.550	0	0
Rab regulation of trafficking	R-HSA-9007101	2.865127e-03	2.543	1	0
SARS-CoV-1-host interactions	R-HSA-9692914	3.010876e-03	2.521	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.693453e-03	2.433	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.706106e-03	2.431	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.790511e-03	2.421	0	0
DNA Replication Pre-Initiation	R-HSA-69002	4.080733e-03	2.389	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.388725e-03	2.358	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.857977e-03	2.314	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.183087e-03	2.285	0	0
FOXO-mediated transcription	R-HSA-9614085	5.269903e-03	2.278	1	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	5.755335e-03	2.240	0	0
Reproduction	R-HSA-1474165	6.007628e-03	2.221	0	0
Metabolism of RNA	R-HSA-8953854	6.357072e-03	2.197	1	0
Signaling by VEGF	R-HSA-194138	6.571280e-03	2.182	1	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.513449e-03	2.186	0	0
Signaling by ALK in cancer	R-HSA-9700206	6.513449e-03	2.186	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.682456e-03	2.175	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	6.707068e-03	2.173	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	6.914567e-03	2.160	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.053759e-03	2.152	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.100491e-03	2.149	0	0
Oncogenic MAPK signaling	R-HSA-6802957	7.330861e-03	2.135	0	0
Type I hemidesmosome assembly	R-HSA-446107	7.411433e-03	2.130	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.411433e-03	2.130	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	7.485940e-03	2.126	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	7.485940e-03	2.126	0	0
Chromosome Maintenance	R-HSA-73886	7.835244e-03	2.106	0	0
Regulation of TP53 Degradation	R-HSA-6804757	8.214699e-03	2.085	1	1
DNA Double-Strand Break Repair	R-HSA-5693532	7.969903e-03	2.099	0	0
Calmodulin induced events	R-HSA-111933	8.214699e-03	2.085	0	0
CaM pathway	R-HSA-111997	8.214699e-03	2.085	0	0
RET signaling	R-HSA-8853659	8.214699e-03	2.085	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	7.695680e-03	2.114	1	0
Adherens junctions interactions	R-HSA-418990	8.209789e-03	2.086	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.441973e-03	2.074	1	1
Kinesins	R-HSA-983189	8.469533e-03	2.072	0	0
PIP3 activates AKT signaling	R-HSA-1257604	8.547130e-03	2.068	1	1
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.514911e-03	2.022	0	0
mRNA Splicing	R-HSA-72172	8.756185e-03	2.058	0	0
PLC beta mediated events	R-HSA-112043	9.571600e-03	2.019	0	0
Ca-dependent events	R-HSA-111996	9.514911e-03	2.022	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	8.668370e-03	2.062	0	0
Cell-cell junction organization	R-HSA-421270	9.632807e-03	2.016	0	0
Amyloid fiber formation	R-HSA-977225	9.756382e-03	2.011	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.049848e-02	1.979	1	1
Interaction between L1 and Ankyrins	R-HSA-445095	1.091051e-02	1.962	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.091051e-02	1.962	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.122628e-02	1.950	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.129548e-02	1.947	0	0
Netrin-1 signaling	R-HSA-373752	1.259591e-02	1.900	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.261875e-02	1.899	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.299200e-02	1.886	1	0
Regulation of TP53 Activity	R-HSA-5633007	1.320029e-02	1.879	1	0
Regulation of endogenous retroelements	R-HSA-9842860	1.340023e-02	1.873	0	0
PI Metabolism	R-HSA-1483255	1.340023e-02	1.873	0	0
Signal attenuation	R-HSA-74749	1.436613e-02	1.843	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.367383e-02	1.864	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.497918e-02	1.825	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.454966e-02	1.837	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.527060e-02	1.816	1	0
Signaling by WNT	R-HSA-195721	1.496808e-02	1.825	1	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.548424e-02	1.810	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.603051e-02	1.795	1	1
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.638818e-02	1.785	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.638818e-02	1.785	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.638818e-02	1.785	0	0
Signaling by RAS mutants	R-HSA-6802949	1.638818e-02	1.785	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.749999e-02	1.757	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.785934e-02	1.748	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.785934e-02	1.748	0	0
Signaling by ERBB2	R-HSA-1227986	1.822338e-02	1.739	1	0
Deubiquitination	R-HSA-5688426	1.831595e-02	1.737	0	0
DCC mediated attractive signaling	R-HSA-418885	1.844085e-02	1.734	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.844085e-02	1.734	0	0
G-protein mediated events	R-HSA-112040	1.875324e-02	1.727	0	0
Homology Directed Repair	R-HSA-5693538	1.959510e-02	1.708	0	0
Ub-specific processing proteases	R-HSA-5689880	2.017611e-02	1.695	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.021472e-02	1.694	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.046988e-02	1.689	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.351892e-02	1.629	0	0
HDMs demethylate histones	R-HSA-3214842	2.119135e-02	1.674	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.119135e-02	1.674	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.296779e-02	1.639	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.161184e-02	1.665	0	0
MTOR signalling	R-HSA-165159	2.231630e-02	1.651	1	1
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.314063e-02	1.636	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.424244e-02	1.615	0	0
TNF signaling	R-HSA-75893	2.449107e-02	1.611	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.462365e-02	1.609	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.462365e-02	1.609	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.473198e-02	1.607	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.683449e-02	1.571	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	2.724862e-02	1.565	0	0
RNA Polymerase I Transcription	R-HSA-73864	2.781703e-02	1.556	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.808945e-02	1.551	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.808945e-02	1.551	0	0
Integrin signaling	R-HSA-354192	2.818877e-02	1.550	1	1
Signaling by NOTCH	R-HSA-157118	2.826469e-02	1.549	1	0
Telomere Maintenance	R-HSA-157579	2.905893e-02	1.537	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.913077e-02	1.536	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.932111e-02	1.533	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	3.267746e-02	1.486	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.267746e-02	1.486	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.134608e-02	1.504	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.134608e-02	1.504	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.458819e-02	1.461	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.229659e-02	1.491	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.046630e-02	1.516	0	0
Amplification of signal from the kinetochores	R-HSA-141424	3.007070e-02	1.522	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.007070e-02	1.522	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.459003e-02	1.461	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.459003e-02	1.461	0	0
Eukaryotic Translation Elongation	R-HSA-156842	3.209945e-02	1.494	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.459003e-02	1.461	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.449418e-02	1.462	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	3.195956e-02	1.495	1	0
Signaling by LTK	R-HSA-9842663	3.134608e-02	1.504	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.001921e-02	1.523	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.542399e-02	1.451	0	0
SARS-CoV-1 Infection	R-HSA-9678108	3.558761e-02	1.449	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.579253e-02	1.446	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.656274e-02	1.437	0	0
Regulation of gene expression in beta cells	R-HSA-210745	3.891197e-02	1.410	1	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.897078e-02	1.409	1	1
Mitotic Prometaphase	R-HSA-68877	4.044392e-02	1.393	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.083097e-02	1.389	0	0
Mitotic Anaphase	R-HSA-68882	4.111332e-02	1.386	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.126302e-02	1.384	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.126302e-02	1.384	0	0
IRS activation	R-HSA-74713	4.126302e-02	1.384	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.126302e-02	1.384	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.126302e-02	1.384	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.126302e-02	1.384	0	0
Breakdown of the nuclear lamina	R-HSA-352238	4.239651e-02	1.373	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.262511e-02	1.370	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.262511e-02	1.370	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.315481e-02	1.365	0	0
Signaling by RAF1 mutants	R-HSA-9656223	4.342238e-02	1.362	0	0
MAP2K and MAPK activation	R-HSA-5674135	4.342238e-02	1.362	0	0
Gene expression (Transcription)	R-HSA-74160	4.433853e-02	1.353	1	0
Interleukin-37 signaling	R-HSA-9008059	4.453817e-02	1.351	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.700669e-02	1.244	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.700669e-02	1.244	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.700669e-02	1.244	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.700669e-02	1.244	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.763221e-02	1.322	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	5.657263e-02	1.247	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.657263e-02	1.247	0	0
IGF1R signaling cascade	R-HSA-2428924	5.318576e-02	1.274	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.203054e-02	1.284	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.666193e-02	1.247	1	1
Regulation of KIT signaling	R-HSA-1433559	4.763221e-02	1.322	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.283398e-02	1.277	1	1
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.666193e-02	1.247	1	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	5.700669e-02	1.244	0	0
Interleukin-7 signaling	R-HSA-1266695	5.401164e-02	1.268	0	0
Semaphorin interactions	R-HSA-373755	4.871674e-02	1.312	0	0
Protein methylation	R-HSA-8876725	5.734357e-02	1.242	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.792637e-02	1.237	0	0
Developmental Biology	R-HSA-1266738	6.380702e-02	1.195	1	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.451532e-02	1.190	0	0
Nuclear RNA decay	R-HSA-9930044	6.451532e-02	1.190	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	6.451532e-02	1.190	0	0
S Phase	R-HSA-69242	6.487594e-02	1.188	1	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.572452e-02	1.182	0	0
Peptide chain elongation	R-HSA-156902	6.666581e-02	1.176	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.810551e-02	1.167	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.810551e-02	1.167	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.810551e-02	1.167	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.011330e-02	1.154	1	1
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.030374e-02	1.153	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	7.030374e-02	1.153	0	0
Diseases of Cellular Senescence	R-HSA-9630747	7.030374e-02	1.153	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.030374e-02	1.153	0	0
Diseases of cellular response to stress	R-HSA-9675132	7.030374e-02	1.153	0	0
C6 deamination of adenosine	R-HSA-75102	7.030374e-02	1.153	0	0
Potassium transport channels	R-HSA-1296067	7.030374e-02	1.153	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.030374e-02	1.153	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.030374e-02	1.153	0	0
Protein ubiquitination	R-HSA-8852135	7.150347e-02	1.146	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.177339e-02	1.144	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.516011e-02	1.124	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.550115e-02	1.122	0	0
Base Excision Repair	R-HSA-73884	7.642275e-02	1.117	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	9.551734e-02	1.020	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.551734e-02	1.020	0	0
SOS-mediated signalling	R-HSA-112412	9.551734e-02	1.020	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	9.551734e-02	1.020	0	0
Activation of RAC1	R-HSA-428540	8.148770e-02	1.089	0	0
Signaling by AXIN mutants	R-HSA-4839735	8.148770e-02	1.089	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	9.730704e-02	1.012	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	9.730704e-02	1.012	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	9.730704e-02	1.012	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	7.990677e-02	1.097	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.572524e-02	1.067	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.572524e-02	1.067	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.043822e-02	1.095	1	1
Interleukin-15 signaling	R-HSA-8983432	9.730704e-02	1.012	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	8.928367e-02	1.049	0	0
Oncogene Induced Senescence	R-HSA-2559585	8.928367e-02	1.049	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.049095e-02	1.094	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	8.751746e-02	1.058	0	0
mTORC1-mediated signalling	R-HSA-166208	8.615869e-02	1.065	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	8.139047e-02	1.089	1	0
DNA Replication	R-HSA-69306	8.367838e-02	1.077	0	0
MAPK family signaling cascades	R-HSA-5683057	8.046866e-02	1.094	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	7.971340e-02	1.098	1	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.049095e-02	1.094	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.699116e-02	1.013	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.759773e-02	1.011	0	0
Syndecan interactions	R-HSA-3000170	9.759773e-02	1.011	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	9.857888e-02	1.006	1	0
Glycolysis	R-HSA-70171	9.984432e-02	1.001	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.017135e-01	0.993	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.023685e-01	0.990	0	0
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.023685e-01	0.990	0	0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.023685e-01	0.990	0	0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.023685e-01	0.990	0	0
MET interacts with TNS proteins	R-HSA-8875513	1.025331e-01	0.989	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.025331e-01	0.989	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.025331e-01	0.989	0	0
Post NMDA receptor activation events	R-HSA-438064	1.033456e-01	0.986	0	0
Generic Transcription Pathway	R-HSA-212436	1.044959e-01	0.981	1	0
TBC/RABGAPs	R-HSA-8854214	1.059533e-01	0.975	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.063248e-01	0.973	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.064791e-01	0.973	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.065278e-01	0.973	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.065278e-01	0.973	0	0
PKA activation	R-HSA-163615	1.065278e-01	0.973	0	0
PKA activation in glucagon signalling	R-HSA-164378	1.065278e-01	0.973	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.096722e-01	0.960	1	0
Deadenylation of mRNA	R-HSA-429947	1.098001e-01	0.959	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.098001e-01	0.959	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.144387e-01	0.941	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.144387e-01	0.941	0	0
Co-inhibition by PD-1	R-HSA-389948	1.153073e-01	0.938	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.178431e-01	0.929	0	0
Formation of annular gap junctions	R-HSA-196025	1.178431e-01	0.929	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.178431e-01	0.929	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.178431e-01	0.929	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.215120e-01	0.915	0	0
TGFBR3 expression	R-HSA-9839394	1.227422e-01	0.911	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.379083e-01	0.860	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.379083e-01	0.860	1	1
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.379083e-01	0.860	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.379083e-01	0.860	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.379083e-01	0.860	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.379083e-01	0.860	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	1.379083e-01	0.860	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	1.379083e-01	0.860	0	0
ARMS-mediated activation	R-HSA-170984	1.418858e-01	0.848	0	0
Lipophagy	R-HSA-9613354	1.418858e-01	0.848	0	0
Gap junction degradation	R-HSA-190873	1.418858e-01	0.848	0	0
ALK mutants bind TKIs	R-HSA-9700645	1.418858e-01	0.848	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.507254e-01	0.822	0	0
Striated Muscle Contraction	R-HSA-390522	1.463140e-01	0.835	0	0
RAF activation	R-HSA-5673000	1.595468e-01	0.797	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.595468e-01	0.797	0	0
Translation initiation complex formation	R-HSA-72649	1.396074e-01	0.855	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.331680e-01	0.876	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.602339e-01	0.795	0	0
Insulin receptor signalling cascade	R-HSA-74751	1.620008e-01	0.790	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.607681e-01	0.794	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.315017e-01	0.881	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.463718e-01	0.835	0	0
mRNA Editing	R-HSA-75072	1.418858e-01	0.848	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.533901e-01	0.814	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.252231e-01	0.902	1	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.379083e-01	0.860	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.379083e-01	0.860	0	0
Dopamine receptors	R-HSA-390651	1.379083e-01	0.860	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.443561e-01	0.841	1	1
G1/S DNA Damage Checkpoints	R-HSA-69615	1.520640e-01	0.818	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.363951e-01	0.865	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.418858e-01	0.848	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.327878e-01	0.877	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.336276e-01	0.874	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.522490e-01	0.817	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.336276e-01	0.874	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.418858e-01	0.848	0	0
Unwinding of DNA	R-HSA-176974	1.418858e-01	0.848	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.297145e-01	0.887	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.545272e-01	0.811	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.632722e-01	0.787	1	1
Regulation of CDH11 gene transcription	R-HSA-9762293	1.418858e-01	0.848	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.646078e-01	0.784	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	1.595468e-01	0.797	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.529380e-01	0.815	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	1.451256e-01	0.838	1	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.602339e-01	0.795	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.535050e-01	0.814	0	0
HDL assembly	R-HSA-8963896	1.327878e-01	0.877	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.652477e-01	0.782	0	0
Formation of apoptosome	R-HSA-111458	1.673872e-01	0.776	0	0
Regulation of the apoptosome activity	R-HSA-9627069	1.673872e-01	0.776	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.673872e-01	0.776	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.673872e-01	0.776	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	1.673872e-01	0.776	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.673872e-01	0.776	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.673872e-01	0.776	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.688794e-01	0.772	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.688794e-01	0.772	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.688794e-01	0.772	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.942631e-01	0.712	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.942631e-01	0.712	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.942631e-01	0.712	0	0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.942631e-01	0.712	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.942631e-01	0.712	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	1.942631e-01	0.712	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.942631e-01	0.712	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	1.942631e-01	0.712	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.942631e-01	0.712	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.942631e-01	0.712	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.754483e-01	0.756	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.754483e-01	0.756	0	0
Activation of AKT2	R-HSA-165158	1.754483e-01	0.756	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.754483e-01	0.756	0	0
PDE3B signalling	R-HSA-165160	2.143399e-01	0.669	0	0
PKB-mediated events	R-HSA-109703	2.143399e-01	0.669	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.143399e-01	0.669	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.143399e-01	0.669	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.539135e-01	0.595	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	2.539135e-01	0.595	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.539135e-01	0.595	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.539135e-01	0.595	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.940907e-01	0.712	1	1
Activated NTRK3 signals through RAS	R-HSA-9034864	1.940907e-01	0.712	0	0
Signaling by APC mutants	R-HSA-4839744	1.940907e-01	0.712	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.940907e-01	0.712	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.940907e-01	0.712	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.940907e-01	0.712	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.727092e-01	0.763	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.217467e-01	0.654	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	2.217467e-01	0.654	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.217467e-01	0.654	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	2.217467e-01	0.654	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.940505e-01	0.712	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.940505e-01	0.712	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.501172e-01	0.602	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.501172e-01	0.602	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.501172e-01	0.602	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.501172e-01	0.602	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.501172e-01	0.602	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.501172e-01	0.602	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.161521e-01	0.665	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.886050e-01	0.724	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.732992e-01	0.761	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.973879e-01	0.705	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.973879e-01	0.705	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.263771e-01	0.645	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.263771e-01	0.645	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.140198e-01	0.670	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.140198e-01	0.670	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.486134e-01	0.604	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.328863e-01	0.633	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.487574e-01	0.604	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.726725e-01	0.763	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	2.329145e-01	0.633	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	2.176884e-01	0.662	0	0
Centrosome maturation	R-HSA-380287	1.929444e-01	0.715	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	1.797366e-01	0.745	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.427176e-01	0.615	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.427176e-01	0.615	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.998554e-01	0.699	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.331185e-01	0.632	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.226819e-01	0.652	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.505053e-01	0.601	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.173695e-01	0.663	0	0
Prolonged ERK activation events	R-HSA-169893	1.727092e-01	0.763	0	0
G0 and Early G1	R-HSA-1538133	2.311115e-01	0.636	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.427176e-01	0.615	1	0
Signaling by PTK6	R-HSA-8848021	2.427176e-01	0.615	1	0
Apoptotic factor-mediated response	R-HSA-111471	2.388928e-01	0.622	0	0
EPHB-mediated forward signaling	R-HSA-3928662	2.047202e-01	0.689	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.822599e-01	0.739	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.479264e-01	0.606	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.808853e-01	0.743	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.940505e-01	0.712	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	2.211838e-01	0.655	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.388928e-01	0.622	0	0
Eukaryotic Translation Initiation	R-HSA-72613	1.747271e-01	0.758	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.754483e-01	0.756	0	0
Hedgehog 'off' state	R-HSA-5610787	2.261837e-01	0.646	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.888144e-01	0.724	0	0
Interleukin-2 family signaling	R-HSA-451927	2.487574e-01	0.604	0	0
Interleukin-2 signaling	R-HSA-9020558	1.940907e-01	0.712	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.940505e-01	0.712	0	0
Cap-dependent Translation Initiation	R-HSA-72737	1.747271e-01	0.758	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	1.937656e-01	0.713	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.710781e-01	0.767	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.143399e-01	0.669	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.973879e-01	0.705	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.055803e-01	0.687	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.055803e-01	0.687	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.055803e-01	0.687	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.055803e-01	0.687	0	0
Opioid Signalling	R-HSA-111885	1.867349e-01	0.729	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.812643e-01	0.742	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.973879e-01	0.705	1	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.456764e-01	0.610	1	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.143399e-01	0.669	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.217467e-01	0.654	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.278229e-01	0.642	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.017964e-01	0.695	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.699087e-01	0.770	0	0
Polo-like kinase mediated events	R-HSA-156711	2.388928e-01	0.622	0	0
Vesicle-mediated transport	R-HSA-5653656	1.922490e-01	0.716	1	0
CDC6 association with the ORC:origin complex	R-HSA-68689	2.143399e-01	0.669	0	0
Signaling by AMER1 mutants	R-HSA-4839748	2.217467e-01	0.654	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.072071e-01	0.684	1	1
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.460415e-01	0.609	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.328863e-01	0.633	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.832694e-01	0.737	0	0
Signaling by NOTCH1	R-HSA-1980143	2.034710e-01	0.691	0	0
DNA Repair	R-HSA-73894	1.921757e-01	0.716	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.211165e-01	0.655	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.311115e-01	0.636	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.055803e-01	0.687	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.847949e-01	0.733	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.779963e-01	0.750	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.143399e-01	0.669	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.977202e-01	0.704	0	0
G2/M Transition	R-HSA-69275	2.308108e-01	0.637	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.454407e-01	0.610	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	2.282275e-01	0.642	1	1
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.143399e-01	0.669	0	0
Signaling by PDGFR in disease	R-HSA-9671555	1.706428e-01	0.768	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.329145e-01	0.633	0	0
Signaling by NOTCH4	R-HSA-9013694	1.826749e-01	0.738	1	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.252523e-01	0.647	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.539135e-01	0.595	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.539135e-01	0.595	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.973879e-01	0.705	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.143399e-01	0.669	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.486134e-01	0.604	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.929444e-01	0.715	0	0
Regulation of beta-cell development	R-HSA-186712	1.937656e-01	0.713	1	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.886050e-01	0.724	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.779278e-01	0.750	0	0
Specification of primordial germ cells	R-HSA-9827857	2.161521e-01	0.665	0	0
Influenza Infection	R-HSA-168255	1.829721e-01	0.738	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.140198e-01	0.670	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.556034e-01	0.592	0	0
Glucose metabolism	R-HSA-70326	2.562662e-01	0.591	0	0
G1/S Transition	R-HSA-69206	2.605881e-01	0.584	1	0
Eukaryotic Translation Termination	R-HSA-72764	2.611807e-01	0.583	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.621525e-01	0.581	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.621525e-01	0.581	0	0
STING mediated induction of host immune responses	R-HSA-1834941	2.621525e-01	0.581	0	0
Maturation of nucleoprotein	R-HSA-9694631	2.621525e-01	0.581	0	0
GPER1 signaling	R-HSA-9634597	2.623644e-01	0.581	0	0
Co-stimulation by CD28	R-HSA-389356	2.623644e-01	0.581	1	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.623644e-01	0.581	0	0
Switching of origins to a post-replicative state	R-HSA-69052	2.641477e-01	0.578	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	2.767549e-01	0.558	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	2.767549e-01	0.558	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.767549e-01	0.558	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	2.767549e-01	0.558	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.767549e-01	0.558	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.767549e-01	0.558	0	0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	2.767549e-01	0.558	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.767549e-01	0.558	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.767549e-01	0.558	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.767549e-01	0.558	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	2.767549e-01	0.558	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.767549e-01	0.558	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.767549e-01	0.558	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	2.767549e-01	0.558	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.508055e-01	0.455	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.508055e-01	0.455	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.508055e-01	0.455	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	3.508055e-01	0.455	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.508055e-01	0.455	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.508055e-01	0.455	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.508055e-01	0.455	0	0
Netrin mediated repulsion signals	R-HSA-418886	2.936222e-01	0.532	0	0
PTK6 Expression	R-HSA-8849473	2.936222e-01	0.532	0	0
The NLRP1 inflammasome	R-HSA-844455	4.172782e-01	0.380	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.172782e-01	0.380	0	0
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	4.172782e-01	0.380	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.172782e-01	0.380	0	0
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	4.172782e-01	0.380	0	0
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	4.172782e-01	0.380	0	0
Invadopodia formation	R-HSA-8941237	4.172782e-01	0.380	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.172782e-01	0.380	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.330238e-01	0.478	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.330238e-01	0.478	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.789787e-01	0.554	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.789787e-01	0.554	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.081240e-01	0.511	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	3.081240e-01	0.511	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.717654e-01	0.430	0	0
HCN channels	R-HSA-1296061	4.769481e-01	0.322	0	0
ATP sensitive Potassium channels	R-HSA-1296025	4.769481e-01	0.322	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.769481e-01	0.322	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.769481e-01	0.322	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.769481e-01	0.322	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.858139e-01	0.544	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.858139e-01	0.544	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.858139e-01	0.544	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.858139e-01	0.544	0	0
Erythropoietin activates RAS	R-HSA-9027284	3.373640e-01	0.472	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.373640e-01	0.472	1	1
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.373640e-01	0.472	0	0
SHC1 events in EGFR signaling	R-HSA-180336	3.373640e-01	0.472	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	3.373640e-01	0.472	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	3.097637e-01	0.509	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.664747e-01	0.574	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.665274e-01	0.436	1	1
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.338937e-01	0.476	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.072638e-01	0.512	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	2.814137e-01	0.551	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.281724e-01	0.484	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.954615e-01	0.403	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.954615e-01	0.403	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.954615e-01	0.403	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.462211e-01	0.350	0	0
PTK6 Down-Regulation	R-HSA-8849472	5.305110e-01	0.275	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.305110e-01	0.275	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.305110e-01	0.275	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.305110e-01	0.275	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.492149e-01	0.457	0	0
IRS-mediated signalling	R-HSA-112399	2.731949e-01	0.564	0	0
PI3K Cascade	R-HSA-109704	2.928415e-01	0.533	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.240314e-01	0.373	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.820246e-01	0.550	0	0
Orc1 removal from chromatin	R-HSA-68949	3.241102e-01	0.489	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.063714e-01	0.391	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.815610e-01	0.317	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.815610e-01	0.317	0	0
Tight junction interactions	R-HSA-420029	4.302625e-01	0.366	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.302625e-01	0.366	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.796247e-01	0.319	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.154731e-01	0.288	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.154731e-01	0.288	0	0
GRB2 events in EGFR signaling	R-HSA-179812	5.154731e-01	0.288	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.581692e-01	0.446	0	0
Viral mRNA Translation	R-HSA-192823	3.514261e-01	0.454	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.771817e-01	0.321	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.771817e-01	0.321	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.771817e-01	0.321	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.771817e-01	0.321	0	0
Regulation of RAS by GAPs	R-HSA-5658442	4.360260e-01	0.360	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.666877e-01	0.436	1	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.064615e-01	0.295	0	0
snRNP Assembly	R-HSA-191859	4.364012e-01	0.360	0	0
Metabolism of non-coding RNA	R-HSA-194441	4.364012e-01	0.360	0	0
HIV elongation arrest and recovery	R-HSA-167287	5.000813e-01	0.301	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	5.000813e-01	0.301	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.514947e-01	0.345	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	4.703926e-01	0.328	0	0
HCMV Early Events	R-HSA-9609690	3.824154e-01	0.417	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.909529e-01	0.309	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.873864e-01	0.312	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.873864e-01	0.312	0	0
Signaling by Erythropoietin	R-HSA-9006335	5.225337e-01	0.282	0	0
Late endosomal microautophagy	R-HSA-9615710	5.225337e-01	0.282	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.225337e-01	0.282	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	4.747866e-01	0.324	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	3.281724e-01	0.484	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	3.492149e-01	0.457	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	4.747866e-01	0.324	0	0
Signaling by NOTCH2	R-HSA-1980145	4.542217e-01	0.343	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.240314e-01	0.373	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.240314e-01	0.373	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.858139e-01	0.544	0	0
Telomere Extension By Telomerase	R-HSA-171319	5.000813e-01	0.301	0	0
Ribosome-associated quality control	R-HSA-9948299	4.107227e-01	0.386	0	0
Activation of the pre-replicative complex	R-HSA-68962	3.492149e-01	0.457	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.839760e-01	0.416	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.538885e-01	0.343	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.838140e-01	0.416	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.330238e-01	0.478	1	1
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.492149e-01	0.457	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	4.240314e-01	0.373	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.399672e-01	0.469	0	0
Frs2-mediated activation	R-HSA-170968	2.789787e-01	0.554	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	3.282097e-01	0.484	1	1
Downregulation of ERBB4 signaling	R-HSA-1253288	3.330238e-01	0.478	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.717654e-01	0.430	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	3.373640e-01	0.472	0	0
PI3K/AKT activation	R-HSA-198203	4.095692e-01	0.388	0	0
LGI-ADAM interactions	R-HSA-5682910	4.462211e-01	0.350	0	0
MET activates RAS signaling	R-HSA-8851805	5.154731e-01	0.288	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.954615e-01	0.403	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.542217e-01	0.343	0	0
G1 Phase	R-HSA-69236	4.909529e-01	0.309	0	0
Cyclin D associated events in G1	R-HSA-69231	4.909529e-01	0.309	0	0
Adrenoceptors	R-HSA-390696	3.330238e-01	0.478	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.717654e-01	0.430	0	0
Regulation of gap junction activity	R-HSA-191650	4.769481e-01	0.322	0	0
DARPP-32 events	R-HSA-180024	3.281724e-01	0.484	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.954615e-01	0.403	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.217056e-01	0.493	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.154731e-01	0.288	0	0
G-protein beta:gamma signalling	R-HSA-397795	4.124968e-01	0.385	1	0
Germ layer formation at gastrulation	R-HSA-9754189	4.796247e-01	0.319	0	0
Signalling to ERKs	R-HSA-187687	3.030717e-01	0.518	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.154731e-01	0.288	0	0
Signaling by FGFR4	R-HSA-5654743	4.725226e-01	0.326	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.254362e-01	0.279	0	0
Resolution of D-Loop Structures	R-HSA-5693537	4.334421e-01	0.363	0	0
Neurexins and neuroligins	R-HSA-6794361	3.241102e-01	0.489	0	0
Developmental Cell Lineages	R-HSA-9734767	3.522404e-01	0.453	0	0
Signaling by FGFR3	R-HSA-5654741	5.091669e-01	0.293	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.081240e-01	0.511	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.717654e-01	0.430	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.462211e-01	0.350	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.305110e-01	0.275	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.124968e-01	0.385	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	4.334421e-01	0.363	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.814137e-01	0.551	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.720154e-01	0.565	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.664747e-01	0.574	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.521195e-01	0.345	0	0
Protein-protein interactions at synapses	R-HSA-6794362	4.223907e-01	0.374	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	4.302625e-01	0.366	0	0
Signaling by FGFR in disease	R-HSA-1226099	3.934942e-01	0.405	0	0
Signaling by Hedgehog	R-HSA-5358351	3.209411e-01	0.494	0	0
Processing of SMDT1	R-HSA-8949664	2.789787e-01	0.554	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.769481e-01	0.322	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.954615e-01	0.403	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.305110e-01	0.275	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.305110e-01	0.275	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.240314e-01	0.373	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.538885e-01	0.343	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.351463e-01	0.361	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.710989e-01	0.431	1	1
Ion homeostasis	R-HSA-5578775	3.880765e-01	0.411	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.815610e-01	0.317	0	0
Hedgehog 'on' state	R-HSA-5632684	4.813868e-01	0.318	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.305110e-01	0.275	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.815610e-01	0.317	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.796247e-01	0.319	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.063714e-01	0.391	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	4.124968e-01	0.385	0	0
TCR signaling	R-HSA-202403	4.462668e-01	0.350	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.767549e-01	0.558	0	0
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	3.508055e-01	0.455	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.508055e-01	0.455	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	4.172782e-01	0.380	0	0
The IPAF inflammasome	R-HSA-844623	4.172782e-01	0.380	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.717654e-01	0.430	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.095692e-01	0.388	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.664747e-01	0.574	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	3.665274e-01	0.436	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.954615e-01	0.403	0	0
Bicarbonate transporters	R-HSA-425381	4.462211e-01	0.350	0	0
Reelin signalling pathway	R-HSA-8866376	5.305110e-01	0.275	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.305110e-01	0.275	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.404963e-01	0.468	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.815610e-01	0.317	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.542217e-01	0.343	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	4.683836e-01	0.329	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.091669e-01	0.293	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.993874e-01	0.302	1	1
Autophagy	R-HSA-9612973	4.202196e-01	0.377	0	0
HCMV Late Events	R-HSA-9610379	3.435562e-01	0.464	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.091669e-01	0.293	0	0
FLT3 signaling in disease	R-HSA-9682385	3.217056e-01	0.493	0	0
Signaling by ERBB4	R-HSA-1236394	2.766645e-01	0.558	0	0
RMTs methylate histone arginines	R-HSA-3214858	4.909529e-01	0.309	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.664747e-01	0.574	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	3.973281e-01	0.401	0	0
Heme signaling	R-HSA-9707616	3.460814e-01	0.461	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.030717e-01	0.518	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.954615e-01	0.403	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.771817e-01	0.321	1	1
Inflammasomes	R-HSA-622312	5.000813e-01	0.301	0	0
Adaptive Immune System	R-HSA-1280218	3.714666e-01	0.430	1	0
Negative regulation of FLT3	R-HSA-9706369	3.665274e-01	0.436	0	0
CHL1 interactions	R-HSA-447041	2.936222e-01	0.532	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	2.936222e-01	0.532	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.936222e-01	0.532	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.330238e-01	0.478	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.717654e-01	0.430	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.664747e-01	0.574	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.164731e-01	0.500	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.666218e-01	0.436	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	3.078401e-01	0.512	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.154731e-01	0.288	0	0
Pervasive developmental disorders	R-HSA-9005895	5.154731e-01	0.288	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.154731e-01	0.288	0	0
Signaling by TGFBR3	R-HSA-9839373	3.666218e-01	0.436	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.302625e-01	0.366	0	0
ISG15 antiviral mechanism	R-HSA-1169408	2.893590e-01	0.539	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.154731e-01	0.288	1	1
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.989542e-01	0.302	0	0
Signaling by SCF-KIT	R-HSA-1433557	3.150366e-01	0.502	0	0
Signaling by TGFB family members	R-HSA-9006936	4.597825e-01	0.337	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.493230e-01	0.457	0	0
DSCAM interactions	R-HSA-376172	3.508055e-01	0.455	0	0
Maturation of nucleoprotein	R-HSA-9683610	2.789787e-01	0.554	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.769481e-01	0.322	0	0
Tandem pore domain potassium channels	R-HSA-1296346	4.095692e-01	0.388	0	0
Synthesis of PI	R-HSA-1483226	4.462211e-01	0.350	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.559332e-01	0.449	0	0
The NLRP3 inflammasome	R-HSA-844456	4.796247e-01	0.319	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.865580e-01	0.543	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.338937e-01	0.476	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.581012e-01	0.446	0	0
Basigin interactions	R-HSA-210991	3.097637e-01	0.509	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.103851e-01	0.292	1	1
Histamine receptors	R-HSA-390650	4.172782e-01	0.380	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.717654e-01	0.430	0	0
Nuclear import of Rev protein	R-HSA-180746	2.846445e-01	0.546	0	0
PECAM1 interactions	R-HSA-210990	4.462211e-01	0.350	0	0
Selenocysteine synthesis	R-HSA-2408557	3.282097e-01	0.484	0	0
Formation of the anterior neural plate	R-HSA-9823739	3.373640e-01	0.472	0	0
Inositol phosphate metabolism	R-HSA-1483249	3.650637e-01	0.438	0	0
The AIM2 inflammasome	R-HSA-844615	3.508055e-01	0.455	0	0
Regulation of PTEN localization	R-HSA-8948747	2.936222e-01	0.532	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.172782e-01	0.380	0	0
Sodium/Proton exchangers	R-HSA-425986	3.330238e-01	0.478	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.717654e-01	0.430	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.769481e-01	0.322	0	0
NrCAM interactions	R-HSA-447038	5.305110e-01	0.275	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	3.973281e-01	0.401	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.973281e-01	0.401	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.162728e-01	0.381	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.631478e-01	0.440	0	0
Signaling by NOTCH3	R-HSA-9012852	3.719791e-01	0.429	0	0
Signaling by ALK	R-HSA-201556	3.783542e-01	0.422	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.703926e-01	0.328	0	0
G1/S-Specific Transcription	R-HSA-69205	4.950918e-01	0.305	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	3.967054e-01	0.402	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.097637e-01	0.509	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.462211e-01	0.350	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.462211e-01	0.350	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.593950e-01	0.444	0	0
PKR-mediated signaling	R-HSA-9833482	3.549133e-01	0.450	0	0
SARS-CoV-2 Infection	R-HSA-9694516	2.736406e-01	0.563	1	0
ChREBP activates metabolic gene expression	R-HSA-163765	4.462211e-01	0.350	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.538885e-01	0.343	0	0
Signaling by Leptin	R-HSA-2586552	4.095692e-01	0.388	0	0
Plasma lipoprotein assembly	R-HSA-8963898	4.063714e-01	0.391	0	0
Muscle contraction	R-HSA-397014	5.315157e-01	0.274	0	0
Cellular response to starvation	R-HSA-9711097	5.316254e-01	0.274	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.325588e-01	0.274	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.325588e-01	0.274	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.325588e-01	0.274	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.325588e-01	0.274	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.325588e-01	0.274	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.347617e-01	0.272	0	0
Signaling by EGFR	R-HSA-177929	5.372955e-01	0.270	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	5.398396e-01	0.268	0	0
L1CAM interactions	R-HSA-373760	5.401254e-01	0.268	0	0
Signaling by Insulin receptor	R-HSA-74752	5.423110e-01	0.266	0	0
DAP12 signaling	R-HSA-2424491	5.444922e-01	0.264	0	0
Formation of axial mesoderm	R-HSA-9796292	5.478795e-01	0.261	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.478795e-01	0.261	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.478795e-01	0.261	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.478795e-01	0.261	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	5.478795e-01	0.261	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.540558e-01	0.256	0	0
Stabilization of p53	R-HSA-69541	5.540558e-01	0.256	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.578586e-01	0.253	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	5.578586e-01	0.253	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.588503e-01	0.253	0	0
EGFR downregulation	R-HSA-182971	5.659163e-01	0.247	0	0
Trafficking of AMPA receptors	R-HSA-399719	5.659163e-01	0.247	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.659163e-01	0.247	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.665172e-01	0.247	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.672372e-01	0.246	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.678691e-01	0.246	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.729485e-01	0.242	0	0
HIV Transcription Elongation	R-HSA-167169	5.729485e-01	0.242	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.729485e-01	0.242	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	5.729485e-01	0.242	1	1
XBP1(S) activates chaperone genes	R-HSA-381038	5.745119e-01	0.241	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.758966e-01	0.240	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.759851e-01	0.240	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	5.777872e-01	0.238	1	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.785917e-01	0.238	0	0
Cam-PDE 1 activation	R-HSA-111957	5.785917e-01	0.238	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.785917e-01	0.238	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.785917e-01	0.238	0	0
Phosphorylation of Emi1	R-HSA-176417	5.785917e-01	0.238	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.785917e-01	0.238	0	0
Terminal pathway of complement	R-HSA-166665	5.785917e-01	0.238	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.785917e-01	0.238	0	0
NGF-independant TRKA activation	R-HSA-187024	5.785917e-01	0.238	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.785917e-01	0.238	0	0
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	5.785917e-01	0.238	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.785917e-01	0.238	0	0
Formation of the Editosome	R-HSA-75094	5.785917e-01	0.238	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.785917e-01	0.238	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.785917e-01	0.238	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	5.785917e-01	0.238	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.785917e-01	0.238	0	0
Hydrolysis of LPC	R-HSA-1483115	5.787328e-01	0.238	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.787328e-01	0.238	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.787328e-01	0.238	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.787328e-01	0.238	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.787328e-01	0.238	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.787328e-01	0.238	0	0
DNA Damage Bypass	R-HSA-73893	5.792926e-01	0.237	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.823154e-01	0.235	0	0
FGFR2 alternative splicing	R-HSA-6803529	5.823154e-01	0.235	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.823154e-01	0.235	0	0
Signaling by WNT in cancer	R-HSA-4791275	5.867719e-01	0.232	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	5.928289e-01	0.227	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	5.960214e-01	0.225	0	0
Selective autophagy	R-HSA-9663891	6.004758e-01	0.222	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.048763e-01	0.218	0	0
Potassium Channels	R-HSA-1296071	6.050607e-01	0.218	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.058947e-01	0.218	1	1
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.070305e-01	0.217	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.070305e-01	0.217	1	1
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.070305e-01	0.217	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.070305e-01	0.217	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.080112e-01	0.216	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.080112e-01	0.216	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	6.080112e-01	0.216	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.080112e-01	0.216	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.080112e-01	0.216	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.080112e-01	0.216	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.080112e-01	0.216	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.080112e-01	0.216	0	0
Signaling by FGFR2	R-HSA-5654738	6.090929e-01	0.215	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	6.094293e-01	0.215	0	0
HCMV Infection	R-HSA-9609646	6.110576e-01	0.214	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	6.123895e-01	0.213	0	0
PTEN Regulation	R-HSA-6807070	6.153699e-01	0.211	1	0
Aquaporin-mediated transport	R-HSA-445717	6.156085e-01	0.211	0	0
MHC class II antigen presentation	R-HSA-2132295	6.176684e-01	0.209	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.189391e-01	0.208	0	0
Regulation of mitotic cell cycle	R-HSA-453276	6.189391e-01	0.208	0	0
Signaling by NTRKs	R-HSA-166520	6.193364e-01	0.208	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.217509e-01	0.206	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.217509e-01	0.206	0	0
STAT5 Activation	R-HSA-9645135	6.217509e-01	0.206	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.217509e-01	0.206	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.217509e-01	0.206	0	0
Hydrolysis of LPE	R-HSA-1483152	6.217509e-01	0.206	0	0
Neurofascin interactions	R-HSA-447043	6.217509e-01	0.206	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.217509e-01	0.206	0	0
Chylomicron clearance	R-HSA-8964026	6.217509e-01	0.206	0	0
Leukotriene receptors	R-HSA-391906	6.217509e-01	0.206	0	0
Downstream TCR signaling	R-HSA-202424	6.256610e-01	0.204	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.283812e-01	0.202	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	6.285718e-01	0.202	0	0
Regulation of insulin secretion	R-HSA-422356	6.289857e-01	0.201	0	0
SARS-CoV Infections	R-HSA-9679506	6.298251e-01	0.201	1	0
tRNA processing in the nucleus	R-HSA-6784531	6.303850e-01	0.200	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.327315e-01	0.199	0	0
Macroautophagy	R-HSA-1632852	6.351304e-01	0.197	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.357138e-01	0.197	0	0
Phosphorylation of the APC/C	R-HSA-176412	6.357138e-01	0.197	0	0
Regulation of BACH1 activity	R-HSA-9708530	6.357138e-01	0.197	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.357138e-01	0.197	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.357138e-01	0.197	0	0
Signal amplification	R-HSA-392518	6.456709e-01	0.190	0	0
IRE1alpha activates chaperones	R-HSA-381070	6.499986e-01	0.187	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.503309e-01	0.187	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.503309e-01	0.187	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.503309e-01	0.187	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	6.543791e-01	0.184	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.543791e-01	0.184	0	0
Mitochondrial biogenesis	R-HSA-1592230	6.566994e-01	0.183	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.604922e-01	0.180	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.604922e-01	0.180	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.604922e-01	0.180	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.604922e-01	0.180	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.604922e-01	0.180	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.604922e-01	0.180	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.604922e-01	0.180	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	6.604922e-01	0.180	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	6.604922e-01	0.180	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.604922e-01	0.180	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.604922e-01	0.180	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.604922e-01	0.180	0	0
VLDL clearance	R-HSA-8964046	6.604922e-01	0.180	0	0
Ca2+ activated K+ channels	R-HSA-1296052	6.604922e-01	0.180	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.604922e-01	0.180	0	0
Activation of TRKA receptors	R-HSA-187015	6.604922e-01	0.180	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	6.604922e-01	0.180	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.604922e-01	0.180	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.604922e-01	0.180	0	0
Amine ligand-binding receptors	R-HSA-375280	6.606027e-01	0.180	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.618561e-01	0.179	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.618561e-01	0.179	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.618561e-01	0.179	0	0
Passive transport by Aquaporins	R-HSA-432047	6.618561e-01	0.179	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.640218e-01	0.178	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	6.711643e-01	0.173	0	0
Metalloprotease DUBs	R-HSA-5689901	6.711643e-01	0.173	0	0
TRP channels	R-HSA-3295583	6.711643e-01	0.173	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	6.711643e-01	0.173	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.711643e-01	0.173	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.711643e-01	0.173	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.711643e-01	0.173	0	0
Myogenesis	R-HSA-525793	6.711643e-01	0.173	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	6.766601e-01	0.170	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.766601e-01	0.170	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.788022e-01	0.168	0	0
Integration of energy metabolism	R-HSA-163685	6.804778e-01	0.167	0	0
RUNX2 regulates bone development	R-HSA-8941326	6.817135e-01	0.166	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	6.817135e-01	0.166	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.817135e-01	0.166	0	0
RNA Polymerase III Transcription	R-HSA-74158	6.817135e-01	0.166	0	0
GPVI-mediated activation cascade	R-HSA-114604	6.817135e-01	0.166	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	6.817135e-01	0.166	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.846413e-01	0.165	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	6.864672e-01	0.163	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.864672e-01	0.163	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.864672e-01	0.163	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.864672e-01	0.163	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.878103e-01	0.163	0	0
Signaling by FGFR1	R-HSA-5654736	6.883456e-01	0.162	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.883456e-01	0.162	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	6.910709e-01	0.160	0	0
Cristae formation	R-HSA-8949613	6.910709e-01	0.160	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.910709e-01	0.160	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.922032e-01	0.160	0	0
Diseases of DNA repair	R-HSA-9675135	6.922032e-01	0.160	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.952676e-01	0.158	0	0
phospho-PLA2 pathway	R-HSA-111995	6.952676e-01	0.158	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.952676e-01	0.158	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.952676e-01	0.158	0	0
MET receptor recycling	R-HSA-8875656	6.952676e-01	0.158	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.952676e-01	0.158	0	0
Interleukin-9 signaling	R-HSA-8985947	6.952676e-01	0.158	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.952676e-01	0.158	0	0
Co-stimulation by ICOS	R-HSA-9927354	6.952676e-01	0.158	0	0
RSK activation	R-HSA-444257	6.952676e-01	0.158	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.959696e-01	0.157	0	0
Translation of Structural Proteins	R-HSA-9694635	6.973332e-01	0.157	0	0
Degradation of AXIN	R-HSA-4641257	6.987412e-01	0.156	0	0
Voltage gated Potassium channels	R-HSA-1296072	6.987412e-01	0.156	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.987412e-01	0.156	0	0
Ovarian tumor domain proteases	R-HSA-5689896	6.987412e-01	0.156	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.987412e-01	0.156	0	0
HIV Life Cycle	R-HSA-162587	7.013193e-01	0.154	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	7.093362e-01	0.149	0	0
Ephrin signaling	R-HSA-3928664	7.095863e-01	0.149	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	7.095863e-01	0.149	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.095863e-01	0.149	0	0
Tie2 Signaling	R-HSA-210993	7.095863e-01	0.149	0	0
Nephron development	R-HSA-9831926	7.095863e-01	0.149	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.100558e-01	0.149	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.100558e-01	0.149	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.100558e-01	0.149	0	0
Formation of the Early Elongation Complex	R-HSA-113418	7.100558e-01	0.149	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.100558e-01	0.149	0	0
Pyroptosis	R-HSA-5620971	7.100558e-01	0.149	0	0
Transcription of the HIV genome	R-HSA-167172	7.119016e-01	0.148	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.119016e-01	0.148	0	0
Neutrophil degranulation	R-HSA-6798695	7.147876e-01	0.146	0	0
MET promotes cell motility	R-HSA-8875878	7.151037e-01	0.146	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.151037e-01	0.146	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.160817e-01	0.145	1	1
COPI-mediated anterograde transport	R-HSA-6807878	7.174181e-01	0.144	0	0
Sensory processing of sound	R-HSA-9659379	7.210233e-01	0.142	0	0
NGF-stimulated transcription	R-HSA-9031628	7.217300e-01	0.142	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.264828e-01	0.139	0	0
WNT mediated activation of DVL	R-HSA-201688	7.264828e-01	0.139	0	0
Interleukin-1 processing	R-HSA-448706	7.264828e-01	0.139	0	0
Interleukin-21 signaling	R-HSA-9020958	7.264828e-01	0.139	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.264828e-01	0.139	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.264828e-01	0.139	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.264828e-01	0.139	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.264828e-01	0.139	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.264828e-01	0.139	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	7.264828e-01	0.139	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.264828e-01	0.139	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.264828e-01	0.139	0	0
mRNA Capping	R-HSA-72086	7.281294e-01	0.138	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	7.281294e-01	0.138	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.281294e-01	0.138	0	0
Platelet calcium homeostasis	R-HSA-418360	7.281294e-01	0.138	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.281294e-01	0.138	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.281294e-01	0.138	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.312609e-01	0.136	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.312609e-01	0.136	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.312609e-01	0.136	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.312609e-01	0.136	0	0
Signaling by MET	R-HSA-6806834	7.323920e-01	0.135	0	0
COPII-mediated vesicle transport	R-HSA-204005	7.362072e-01	0.133	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.362072e-01	0.133	0	0
Synthesis of DNA	R-HSA-69239	7.362504e-01	0.133	0	0
Cellular response to chemical stress	R-HSA-9711123	7.372405e-01	0.132	1	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.434409e-01	0.129	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.453064e-01	0.128	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.458445e-01	0.127	0	0
Generation of second messenger molecules	R-HSA-202433	7.458445e-01	0.127	0	0
Aggrephagy	R-HSA-9646399	7.458445e-01	0.127	0	0
Glycogen metabolism	R-HSA-8982491	7.458445e-01	0.127	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.515443e-01	0.124	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.515443e-01	0.124	0	0
Acyl chain remodelling of PI	R-HSA-1482922	7.515443e-01	0.124	0	0
Signaling by NODAL	R-HSA-1181150	7.515443e-01	0.124	0	0
Protein hydroxylation	R-HSA-9629569	7.515443e-01	0.124	0	0
Signal transduction by L1	R-HSA-445144	7.515443e-01	0.124	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	7.515443e-01	0.124	0	0
2-LTR circle formation	R-HSA-164843	7.545021e-01	0.122	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.545021e-01	0.122	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.545021e-01	0.122	0	0
Regulation of CDH11 function	R-HSA-9762292	7.545021e-01	0.122	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	7.545021e-01	0.122	0	0
CASP4 inflammasome assembly	R-HSA-9948001	7.545021e-01	0.122	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.545021e-01	0.122	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.545021e-01	0.122	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	7.545021e-01	0.122	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.545021e-01	0.122	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.545021e-01	0.122	0	0
Maturation of spike protein	R-HSA-9683686	7.545021e-01	0.122	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.545021e-01	0.122	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.545021e-01	0.122	0	0
Josephin domain DUBs	R-HSA-5689877	7.545021e-01	0.122	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.574832e-01	0.121	0	0
Hemostasis	R-HSA-109582	7.579544e-01	0.120	1	0
rRNA processing	R-HSA-72312	7.588190e-01	0.120	0	0
Maturation of spike protein	R-HSA-9694548	7.602351e-01	0.119	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.602351e-01	0.119	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.616052e-01	0.118	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	7.621182e-01	0.118	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.643285e-01	0.117	0	0
Cytoprotection by HMOX1	R-HSA-9707564	7.645774e-01	0.117	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.656003e-01	0.116	0	0
Ca2+ pathway	R-HSA-4086398	7.699152e-01	0.114	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.704939e-01	0.113	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.704939e-01	0.113	0	0
Signalling to RAS	R-HSA-167044	7.704939e-01	0.113	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.739849e-01	0.111	0	0
HIV Transcription Initiation	R-HSA-167161	7.739849e-01	0.111	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.739849e-01	0.111	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.739849e-01	0.111	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.739849e-01	0.111	0	0
Translation of Structural Proteins	R-HSA-9683701	7.739849e-01	0.111	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.745525e-01	0.111	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.745525e-01	0.111	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.769784e-01	0.110	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	7.770474e-01	0.110	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.770474e-01	0.110	0	0
DNA strand elongation	R-HSA-69190	7.770474e-01	0.110	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	7.796526e-01	0.108	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.796526e-01	0.108	0	0
FGFR2b ligand binding and activation	R-HSA-190377	7.796526e-01	0.108	0	0
vRNA Synthesis	R-HSA-192814	7.796526e-01	0.108	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.796526e-01	0.108	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.796526e-01	0.108	0	0
Transport of RCbl within the body	R-HSA-9758890	7.796526e-01	0.108	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.796526e-01	0.108	0	0
Suppression of apoptosis	R-HSA-9635465	7.796526e-01	0.108	0	0
Prostanoid ligand receptors	R-HSA-391908	7.796526e-01	0.108	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.811533e-01	0.107	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.864825e-01	0.104	0	0
Amino acids regulate mTORC1	R-HSA-9639288	7.864825e-01	0.104	0	0
Smooth Muscle Contraction	R-HSA-445355	7.864825e-01	0.104	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.864825e-01	0.104	1	1
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.868680e-01	0.104	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.881701e-01	0.103	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.881701e-01	0.103	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.881701e-01	0.103	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.881701e-01	0.103	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.881701e-01	0.103	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.881701e-01	0.103	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.881701e-01	0.103	0	0
Regulation of necroptotic cell death	R-HSA-5675482	7.916571e-01	0.101	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.916571e-01	0.101	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.916571e-01	0.101	0	0
Cardiogenesis	R-HSA-9733709	7.916571e-01	0.101	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.979159e-01	0.098	0	0
Cellular response to hypoxia	R-HSA-1234174	7.984779e-01	0.098	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.996104e-01	0.097	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.996104e-01	0.097	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.996104e-01	0.097	0	0
Cardiac conduction	R-HSA-5576891	7.996853e-01	0.097	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.022278e-01	0.096	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.022278e-01	0.096	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.022278e-01	0.096	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.022278e-01	0.096	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.022278e-01	0.096	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.022278e-01	0.096	0	0
Sodium/Calcium exchangers	R-HSA-425561	8.022278e-01	0.096	0	0
Integration of provirus	R-HSA-162592	8.022278e-01	0.096	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.045294e-01	0.094	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.046349e-01	0.094	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.046349e-01	0.094	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.046349e-01	0.094	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.046349e-01	0.094	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.046349e-01	0.094	0	0
LDL clearance	R-HSA-8964038	8.046349e-01	0.094	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.054604e-01	0.094	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.054604e-01	0.094	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.054604e-01	0.094	0	0
Circadian clock	R-HSA-9909396	8.069632e-01	0.093	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.088618e-01	0.092	0	0
G alpha (z) signalling events	R-HSA-418597	8.088618e-01	0.092	0	0
DAP12 interactions	R-HSA-2172127	8.115142e-01	0.091	0	0
Interleukin-1 family signaling	R-HSA-446652	8.158714e-01	0.088	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.183405e-01	0.087	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.184852e-01	0.087	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.184852e-01	0.087	0	0
Mitophagy	R-HSA-5205647	8.184852e-01	0.087	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.184852e-01	0.087	0	0
PCP/CE pathway	R-HSA-4086400	8.188800e-01	0.087	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.193302e-01	0.087	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	8.199510e-01	0.086	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.199510e-01	0.086	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.199510e-01	0.086	0	0
Formation of the ureteric bud	R-HSA-9830674	8.199510e-01	0.086	0	0
Carnitine shuttle	R-HSA-200425	8.199510e-01	0.086	0	0
Growth hormone receptor signaling	R-HSA-982772	8.199510e-01	0.086	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.224913e-01	0.085	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.224913e-01	0.085	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.224913e-01	0.085	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.224913e-01	0.085	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.224913e-01	0.085	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.224913e-01	0.085	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.224913e-01	0.085	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.224913e-01	0.085	0	0
OAS antiviral response	R-HSA-8983711	8.224913e-01	0.085	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.228331e-01	0.085	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.228331e-01	0.085	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.228331e-01	0.085	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.257655e-01	0.083	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.276263e-01	0.082	0	0
Regulated Necrosis	R-HSA-5218859	8.276754e-01	0.082	0	0
Phospholipid metabolism	R-HSA-1483257	8.299358e-01	0.081	0	0
Signaling by FGFR	R-HSA-190236	8.303026e-01	0.081	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.307601e-01	0.081	0	0
Acyl chain remodelling of PE	R-HSA-1482839	8.307601e-01	0.081	0	0
PERK regulates gene expression	R-HSA-381042	8.307601e-01	0.081	0	0
Stimuli-sensing channels	R-HSA-2672351	8.324575e-01	0.080	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.341807e-01	0.079	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.404657e-01	0.075	0	0
Adenylate cyclase activating pathway	R-HSA-170660	8.406797e-01	0.075	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.406797e-01	0.075	0	0
FGFR1c ligand binding and activation	R-HSA-190373	8.406797e-01	0.075	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.406797e-01	0.075	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.406797e-01	0.075	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.406797e-01	0.075	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.406797e-01	0.075	0	0
Chylomicron remodeling	R-HSA-8963901	8.406797e-01	0.075	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.406797e-01	0.075	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.406797e-01	0.075	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.406797e-01	0.075	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.406797e-01	0.075	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.406797e-01	0.075	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.406797e-01	0.075	0	0
Triglyceride catabolism	R-HSA-163560	8.423149e-01	0.075	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.437844e-01	0.074	0	0
Recycling pathway of L1	R-HSA-437239	8.437844e-01	0.074	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.473859e-01	0.072	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.473859e-01	0.072	0	0
Long-term potentiation	R-HSA-9620244	8.473859e-01	0.072	0	0
Laminin interactions	R-HSA-3000157	8.473859e-01	0.072	0	0
Hyaluronan degradation	R-HSA-2160916	8.473859e-01	0.072	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.479821e-01	0.072	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.519996e-01	0.070	0	0
Degradation of DVL	R-HSA-4641258	8.531797e-01	0.069	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.531797e-01	0.069	0	0
Metal ion SLC transporters	R-HSA-425410	8.534529e-01	0.069	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.566554e-01	0.067	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.570054e-01	0.067	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.570054e-01	0.067	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.570054e-01	0.067	0	0
cGMP effects	R-HSA-418457	8.570054e-01	0.067	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.570054e-01	0.067	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.570054e-01	0.067	0	0
Non-canonical inflammasome activation	R-HSA-9686114	8.570054e-01	0.067	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.570054e-01	0.067	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.570054e-01	0.067	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.570054e-01	0.067	0	0
Zinc transporters	R-HSA-435354	8.570054e-01	0.067	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	8.583265e-01	0.066	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.586066e-01	0.066	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.596271e-01	0.066	0	0
Degradation of CDH1	R-HSA-9766229	8.626082e-01	0.064	0	0
Gap junction trafficking and regulation	R-HSA-157858	8.626082e-01	0.064	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.633848e-01	0.064	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.709630e-01	0.060	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.709630e-01	0.060	0	0
Signaling by BMP	R-HSA-201451	8.709630e-01	0.060	0	0
Insulin processing	R-HSA-264876	8.709630e-01	0.060	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.716591e-01	0.060	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.716591e-01	0.060	0	0
Protein lipoylation	R-HSA-9857492	8.716591e-01	0.060	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.716591e-01	0.060	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.716591e-01	0.060	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.716591e-01	0.060	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.716591e-01	0.060	0	0
Spry regulation of FGF signaling	R-HSA-1295596	8.716591e-01	0.060	0	0
Other semaphorin interactions	R-HSA-416700	8.716591e-01	0.060	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.716591e-01	0.060	0	0
DNA Damage Reversal	R-HSA-73942	8.716591e-01	0.060	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.727633e-01	0.059	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.729606e-01	0.059	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.729606e-01	0.059	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.782001e-01	0.056	0	0
Neuronal System	R-HSA-112316	8.790177e-01	0.056	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.794555e-01	0.056	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.802248e-01	0.055	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.814508e-01	0.055	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.814508e-01	0.055	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.819371e-01	0.055	0	0
Diseases of Immune System	R-HSA-5260271	8.819371e-01	0.055	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.819371e-01	0.055	0	0
Selenoamino acid metabolism	R-HSA-2408522	8.824231e-01	0.054	0	0
Killing mechanisms	R-HSA-9664420	8.848118e-01	0.053	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.848118e-01	0.053	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.848118e-01	0.053	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.848118e-01	0.053	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.848118e-01	0.053	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.848118e-01	0.053	0	0
Differentiation of T cells	R-HSA-9945266	8.848118e-01	0.053	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.848118e-01	0.053	0	0
Attachment and Entry	R-HSA-9678110	8.848118e-01	0.053	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.884424e-01	0.051	0	0
UCH proteinases	R-HSA-5689603	8.891997e-01	0.051	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.903439e-01	0.050	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.903439e-01	0.050	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.903439e-01	0.050	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.911450e-01	0.050	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.911450e-01	0.050	0	0
Chaperonin-mediated protein folding	R-HSA-390466	8.920751e-01	0.050	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.966174e-01	0.047	0	0
Glycine degradation	R-HSA-6783984	8.966174e-01	0.047	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.966174e-01	0.047	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.966174e-01	0.047	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.966174e-01	0.047	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.982103e-01	0.047	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.000982e-01	0.046	0	0
ER-Phagosome pathway	R-HSA-1236974	9.032490e-01	0.044	0	0
Cilium Assembly	R-HSA-5617833	9.055939e-01	0.043	0	0
Kidney development	R-HSA-9830369	9.064403e-01	0.043	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.072136e-01	0.042	0	0
Glycogen storage diseases	R-HSA-3229121	9.072136e-01	0.042	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.072136e-01	0.042	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.072136e-01	0.042	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.072136e-01	0.042	0	0
Catecholamine biosynthesis	R-HSA-209905	9.072136e-01	0.042	0	0
Choline catabolism	R-HSA-6798163	9.072136e-01	0.042	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	9.072136e-01	0.042	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.083604e-01	0.042	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.083604e-01	0.042	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	9.083604e-01	0.042	0	0
Leishmania phagocytosis	R-HSA-9664417	9.147613e-01	0.039	0	0
Parasite infection	R-HSA-9664407	9.147613e-01	0.039	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.147613e-01	0.039	0	0
G alpha (s) signalling events	R-HSA-418555	9.149821e-01	0.039	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.159791e-01	0.038	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.167243e-01	0.038	0	0
GAB1 signalosome	R-HSA-180292	9.167243e-01	0.038	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.167243e-01	0.038	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.167243e-01	0.038	0	0
FGFR1 ligand binding and activation	R-HSA-190242	9.167243e-01	0.038	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	9.167243e-01	0.038	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.167243e-01	0.038	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.167243e-01	0.038	0	0
Mismatch Repair	R-HSA-5358508	9.167243e-01	0.038	0	0
Platelet sensitization by LDL	R-HSA-432142	9.167243e-01	0.038	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	9.167243e-01	0.038	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.167243e-01	0.038	0	0
Proteasome assembly	R-HSA-9907900	9.188468e-01	0.037	0	0
Gap junction trafficking	R-HSA-190828	9.188468e-01	0.037	0	0
Protein folding	R-HSA-391251	9.226574e-01	0.035	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.226574e-01	0.035	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.229994e-01	0.035	0	0
Interferon Signaling	R-HSA-913531	9.231644e-01	0.035	0	0
HIV Infection	R-HSA-162906	9.245585e-01	0.034	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.248275e-01	0.034	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.248275e-01	0.034	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.248275e-01	0.034	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.250532e-01	0.034	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.252606e-01	0.034	0	0
Regulation of signaling by CBL	R-HSA-912631	9.252606e-01	0.034	0	0
Specification of the neural plate border	R-HSA-9834899	9.252606e-01	0.034	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.252606e-01	0.034	0	0
Other interleukin signaling	R-HSA-449836	9.252606e-01	0.034	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.252606e-01	0.034	1	1
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.265791e-01	0.033	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.269458e-01	0.033	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.274978e-01	0.033	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.294639e-01	0.032	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.294639e-01	0.032	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.294639e-01	0.032	0	0
Heme degradation	R-HSA-189483	9.294639e-01	0.032	0	0
Extension of Telomeres	R-HSA-180786	9.301149e-01	0.031	0	0
Triglyceride metabolism	R-HSA-8979227	9.301149e-01	0.031	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.304015e-01	0.031	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.304015e-01	0.031	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.304015e-01	0.031	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.309771e-01	0.031	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.320549e-01	0.031	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.329224e-01	0.030	0	0
Glycogen synthesis	R-HSA-3322077	9.329224e-01	0.030	0	0
Co-inhibition by CTLA4	R-HSA-389513	9.329224e-01	0.030	1	1
Negative regulation of MET activity	R-HSA-6807004	9.329224e-01	0.030	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.329224e-01	0.030	0	0
Nephrin family interactions	R-HSA-373753	9.329224e-01	0.030	0	0
RAB geranylgeranylation	R-HSA-8873719	9.348656e-01	0.029	0	0
Dual Incision in GG-NER	R-HSA-5696400	9.354127e-01	0.029	0	0
Hyaluronan metabolism	R-HSA-2142845	9.354127e-01	0.029	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.354127e-01	0.029	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.354127e-01	0.029	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.354786e-01	0.029	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.354786e-01	0.029	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.355928e-01	0.029	0	0
MAP kinase activation	R-HSA-450294	9.393214e-01	0.027	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.393214e-01	0.027	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.397992e-01	0.027	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.397992e-01	0.027	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.397992e-01	0.027	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.397992e-01	0.027	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	9.397992e-01	0.027	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.408837e-01	0.026	0	0
Regulation of Apoptosis	R-HSA-169911	9.408837e-01	0.026	0	0
Platelet degranulation	R-HSA-114608	9.410871e-01	0.026	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.420874e-01	0.026	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.434979e-01	0.025	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.454459e-01	0.024	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.459121e-01	0.024	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.459713e-01	0.024	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.459713e-01	0.024	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.459713e-01	0.024	0	0
Serine metabolism	R-HSA-977347	9.459713e-01	0.024	0	0
Attachment and Entry	R-HSA-9694614	9.459713e-01	0.024	0	0
Gastrulation	R-HSA-9758941	9.468407e-01	0.024	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	9.472495e-01	0.024	1	0
Leishmania infection	R-HSA-9658195	9.501775e-01	0.022	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.501775e-01	0.022	0	0
Signaling by Interleukins	R-HSA-449147	9.510283e-01	0.022	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	9.513101e-01	0.022	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	9.513101e-01	0.022	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.515109e-01	0.022	0	0
Ethanol oxidation	R-HSA-71384	9.515109e-01	0.022	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.515109e-01	0.022	0	0
Signaling by KIT in disease	R-HSA-9669938	9.515109e-01	0.022	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.515109e-01	0.022	0	0
The phototransduction cascade	R-HSA-2514856	9.529758e-01	0.021	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.541429e-01	0.020	0	0
Integrin cell surface interactions	R-HSA-216083	9.543955e-01	0.020	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.544996e-01	0.020	0	0
Elastic fibre formation	R-HSA-1566948	9.547723e-01	0.020	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.564828e-01	0.019	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.564828e-01	0.019	0	0
Biosynthesis of maresins	R-HSA-9018682	9.564828e-01	0.019	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.564828e-01	0.019	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.564828e-01	0.019	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.564828e-01	0.019	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	9.565783e-01	0.019	0	0
Interleukin-1 signaling	R-HSA-9020702	9.570597e-01	0.019	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.586639e-01	0.018	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.586639e-01	0.018	0	0
Neddylation	R-HSA-8951664	9.604081e-01	0.018	0	0
CYP2E1 reactions	R-HSA-211999	9.609452e-01	0.017	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	9.609452e-01	0.017	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.609452e-01	0.017	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.609452e-01	0.017	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.609452e-01	0.017	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.609452e-01	0.017	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.609452e-01	0.017	0	0
Formation of the cornified envelope	R-HSA-6809371	9.612241e-01	0.017	0	0
Host Interactions of HIV factors	R-HSA-162909	9.612241e-01	0.017	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.622334e-01	0.017	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.622334e-01	0.017	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.622334e-01	0.017	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.649503e-01	0.015	0	0
G protein gated Potassium channels	R-HSA-1296059	9.649503e-01	0.015	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.649503e-01	0.015	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.649503e-01	0.015	0	0
Formation of the nephric duct	R-HSA-9830364	9.649503e-01	0.015	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.652696e-01	0.015	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.655058e-01	0.015	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.658937e-01	0.015	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.676586e-01	0.014	0	0
Viral Infection Pathways	R-HSA-9824446	9.677211e-01	0.014	1	0
Collagen formation	R-HSA-1474290	9.677441e-01	0.014	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.685044e-01	0.014	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.685044e-01	0.014	0	0
Interleukin-17 signaling	R-HSA-448424	9.685427e-01	0.014	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.685448e-01	0.014	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.685448e-01	0.014	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.685448e-01	0.014	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.685448e-01	0.014	0	0
Urea cycle	R-HSA-70635	9.685448e-01	0.014	0	0
Sphingolipid catabolism	R-HSA-9845614	9.685448e-01	0.014	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.685448e-01	0.014	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.685552e-01	0.014	0	0
Immune System	R-HSA-168256	9.686916e-01	0.014	1	0
Activation of GABAB receptors	R-HSA-991365	9.712510e-01	0.013	0	0
GABA B receptor activation	R-HSA-977444	9.712510e-01	0.013	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.712510e-01	0.013	0	0
Triglyceride biosynthesis	R-HSA-75109	9.717709e-01	0.012	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.723015e-01	0.012	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.735543e-01	0.012	0	0
Insulin receptor recycling	R-HSA-77387	9.746663e-01	0.011	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.746663e-01	0.011	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.746663e-01	0.011	0	0
Pyrimidine salvage	R-HSA-73614	9.746663e-01	0.011	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.754096e-01	0.011	0	0
GPCR downstream signalling	R-HSA-388396	9.756295e-01	0.011	1	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.772649e-01	0.010	0	0
Somitogenesis	R-HSA-9824272	9.781729e-01	0.010	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.795713e-01	0.009	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.795970e-01	0.009	1	1
Neurotransmitter clearance	R-HSA-112311	9.795970e-01	0.009	0	0
Interleukin-12 signaling	R-HSA-9020591	9.800443e-01	0.009	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.800985e-01	0.009	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.800985e-01	0.009	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.802945e-01	0.009	0	0
Mitochondrial protein import	R-HSA-1268020	9.808280e-01	0.008	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.815241e-01	0.008	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.816901e-01	0.008	0	0
Cargo concentration in the ER	R-HSA-5694530	9.816901e-01	0.008	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.816901e-01	0.008	0	0
Downstream signal transduction	R-HSA-186763	9.816901e-01	0.008	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.816901e-01	0.008	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.818589e-01	0.008	0	0
ABC transporter disorders	R-HSA-5619084	9.828997e-01	0.007	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.843932e-01	0.007	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.845431e-01	0.007	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.849374e-01	0.007	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.849374e-01	0.007	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.852544e-01	0.006	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.852544e-01	0.006	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.863022e-01	0.006	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.874156e-01	0.006	0	0
Platelet homeostasis	R-HSA-418346	9.875515e-01	0.005	0	0
eNOS activation	R-HSA-203615	9.881251e-01	0.005	1	1
Calnexin/calreticulin cycle	R-HSA-901042	9.881251e-01	0.005	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.881251e-01	0.005	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.884393e-01	0.005	0	0
SLC transporter disorders	R-HSA-5619102	9.893979e-01	0.005	0	0
Adipogenesis	R-HSA-9843745	9.894824e-01	0.005	0	0
PPARA activates gene expression	R-HSA-1989781	9.897285e-01	0.004	0	0
Glycosphingolipid transport	R-HSA-9845576	9.904373e-01	0.004	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.904373e-01	0.004	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.909066e-01	0.004	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.914187e-01	0.004	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.914187e-01	0.004	0	0
Lysine catabolism	R-HSA-71064	9.914187e-01	0.004	0	0
Collagen chain trimerization	R-HSA-8948216	9.914187e-01	0.004	0	0
Paracetamol ADME	R-HSA-9753281	9.914247e-01	0.004	0	0
Interferon gamma signaling	R-HSA-877300	9.919575e-01	0.004	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.921988e-01	0.003	0	0
Interleukin-12 family signaling	R-HSA-447115	9.922407e-01	0.003	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.922994e-01	0.003	1	0
ABC-family proteins mediated transport	R-HSA-382556	9.924778e-01	0.003	0	0
RAS processing	R-HSA-9648002	9.930898e-01	0.003	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.931000e-01	0.003	0	0
Dual incision in TC-NER	R-HSA-6782135	9.935475e-01	0.003	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.935475e-01	0.003	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.936740e-01	0.003	0	0
Neurotransmitter release cycle	R-HSA-112310	9.939111e-01	0.003	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.944356e-01	0.002	0	0
Signaling by GPCR	R-HSA-372790	9.946566e-01	0.002	1	0
GABA receptor activation	R-HSA-977443	9.946669e-01	0.002	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.946669e-01	0.002	0	0
Metabolism of polyamines	R-HSA-351202	9.946669e-01	0.002	0	0
G alpha (q) signalling events	R-HSA-416476	9.950031e-01	0.002	0	0
Intra-Golgi traffic	R-HSA-6811438	9.950069e-01	0.002	0	0
Cholesterol biosynthesis	R-HSA-191273	9.951318e-01	0.002	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.955195e-01	0.002	0	0
Signaling by PDGF	R-HSA-186797	9.955952e-01	0.002	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.957870e-01	0.002	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.957870e-01	0.002	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.959552e-01	0.002	0	0
Pyrimidine catabolism	R-HSA-73621	9.959795e-01	0.002	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.959795e-01	0.002	0	0
tRNA processing	R-HSA-72306	9.962261e-01	0.002	0	0
Surfactant metabolism	R-HSA-5683826	9.963923e-01	0.002	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.963923e-01	0.002	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.966307e-01	0.001	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.966307e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.972543e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.972769e-01	0.001	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.973285e-01	0.001	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.973285e-01	0.001	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.973285e-01	0.001	0	0
Ion channel transport	R-HSA-983712	9.974130e-01	0.001	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.974477e-01	0.001	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.975277e-01	0.001	0	0
Intraflagellar transport	R-HSA-5620924	9.976612e-01	0.001	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.976612e-01	0.001	0	0
Gluconeogenesis	R-HSA-70263	9.976612e-01	0.001	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.977238e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.978067e-01	0.001	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.979014e-01	0.001	0	0
Pyruvate metabolism	R-HSA-70268	9.979946e-01	0.001	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.980021e-01	0.001	0	0
Azathioprine ADME	R-HSA-9748787	9.981169e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.981515e-01	0.001	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.981515e-01	0.001	0	0
Metabolism of porphyrins	R-HSA-189445	9.981515e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.981558e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.983104e-01	0.001	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.983104e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.983665e-01	0.001	0	0
RSV-host interactions	R-HSA-9833110	9.985184e-01	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.986397e-01	0.001	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.987516e-01	0.001	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.987516e-01	0.001	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.989467e-01	0.000	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.990174e-01	0.000	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.990333e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.991114e-01	0.000	0	0
Dectin-2 family	R-HSA-5621480	9.991183e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.991183e-01	0.000	0	0
Translation	R-HSA-72766	9.991532e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.992278e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.992792e-01	0.000	0	0
Peroxisomal protein import	R-HSA-9033241	9.992902e-01	0.000	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.993152e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.993632e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.994286e-01	0.000	0	0
Collagen degradation	R-HSA-1442490	9.994286e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.995173e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.995401e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.995873e-01	0.000	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.995873e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.996298e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.996770e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.997413e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.997544e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.997848e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.998069e-01	0.000	1	0
Retinoid metabolism and transport	R-HSA-975634	9.998069e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.998268e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.998318e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.998446e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.998446e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.998749e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.998949e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.998960e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999046e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999348e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999348e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999556e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999727e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999808e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999844e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999845e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999850e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999858e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.999873e-01	0.000	0	0
Disease	R-HSA-1643685	9.999892e-01	0.000	1	0
Peptide hormone metabolism	R-HSA-2980736	9.999897e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999931e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999954e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999966e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999969e-01	0.000	1	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999976e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999980e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999986e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999989e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999996e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999996e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999998e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999999e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	1	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	1	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0