ROCK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00429 S637 SIGNOR DNM1L DLP1 DRP1 PQKGHAVNLLDVPVPVARKLsAREQRDCEVIERLIKSYFLI
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14649 S336 SIGNOR|PSP KCNK3 TASK TASK1 KSREKLQySIPMIIPRDLSTsDTCVEQSHSSPGGGGRYSDT
O14649 S393 SIGNOR|PSP KCNK3 TASK TASK1 sVsTGLHSLStFRGLMKRRssV___________________
O14744 T80 EPSD|PSP PRMT5 HRMT1L5 IBP72 JBP1 SKB1 KNRPGPQTRSDLLLSGRDWNtLIVGKLSPWIRPDSKVEKIR
O14950 S20 SIGNOR|EPSD|PSP|Sugiyama MYL12B MRLC2 MYLC2B _MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14950 T19 SIGNOR|EPSD|PSP|Sugiyama MYL12B MRLC2 MYLC2B __MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
O14974 S692 Sugiyama PPP1R12A MBS MYPT1 PVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIG
O14974 S852 EPSD|PSP PPP1R12A MBS MYPT1 EDKSQPKSIRERRRPREKRRstGVSFWtQDsDENEQEQQsD
O14974 S903 Sugiyama PPP1R12A MBS MYPT1 QtDsIsRyETssTsAGDRyDsLLGRsGsysYLEERKPYSSR
O14974 T696 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14974 T700 Sugiyama PPP1R12A MBS MYPT1 sQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRSTRTR
O14974 T853 SIGNOR|iPTMNet|EPSD|PSP PPP1R12A MBS MYPT1 DKSQPKSIRERRRPREKRRstGVSFWtQDsDENEQEQQsDt
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O43175 T78 Sugiyama PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43293 T265 GPS6|EPSD|PSP DAPK3 ZIPK SELAKDFIRRLLVKDPKRRMtIAQSLEHSWIKAIRRRNVRG
O43293 T299 GPS6|EPSD|PSP DAPK3 ZIPK RRRNVRGEDSGRKPERRRLKtTRLKEYtIKsHssLPPNNsY
O43318 S439 Sugiyama MAP3K7 TAK1 GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O60237 T646 SIGNOR|EPSD|PSP PPP1R12B MYPT2 EEAESLRKARSRQARQTRRstQGVTLTDLQEAERTFSRSRA
O60739 T45 Sugiyama EIF1B AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 T78 Sugiyama EIF5B IF2 KIAA0741 ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O75116 S134 Sugiyama ROCK2 KIAA0619 SQKVYAMKLLSKFEMIKRSDsAFFWEERDIMAFANSPWVVQ
O75116 T235 Sugiyama ROCK2 KIAA0619 VKPDNMLLDKHGHLKLADFGtCMKMDETGMVHCDtAVGTPD
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O95425 T852 Sugiyama SVIL AISTRNRIDTRQRRMNARyQtQPVTLGEVEQVQSGKLIPFS
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02545 S282 Sugiyama LMNA LMN1 ELEKTYSAKLDNARQsAERNsNLVGAAHEELQQsRIRIDsL
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04150 S617 PSP NR3C1 GRL QYSWMFLMAFALGWRSYRQSsANLLCFAPDLIINEQRMtLP
P04150 T519 PSP NR3C1 GRL GIQQATTGVsQETSENPGNKtIVPAtLPQLTPTLVSLLEVI
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06737 S430 Sugiyama PYGL KHLDRIVALFPKDVDRLRRMsLIEEEGSKRINMAHLCIVGS
P06744 S107 Sugiyama GPI GEKINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLD
P06744 T109 Sugiyama GPI KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07737 S138 GPS6|SIGNOR|EPSD|PSP PFN1 GVHGGLINKKCyEMAsHLRRsQY__________________
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08670 S72 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP VIM LyAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAI
P08670 T327 Sugiyama VIM DALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMREM
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11441 S128 Sugiyama UBL4A DXS254E GDX UBL4 SAADASRVLEQLQRDYERSLsRLTLDDIERLASRFLHPEVT
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14136 S13 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP GFAP ________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136 S17 iPTMNet|EPSD GFAP ____MERRRItsAARRsYVssGEMMVGGLAPGRRLGPGTRL
P14136 S38 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP GFAP GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14136 T7 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP GFAP ______________MERRRItsAARRsYVssGEMMVGGLAP
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15311 T567 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15880 T202 Sugiyama RPS2 RPS4 CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880 T230 Sugiyama RPS2 RPS4 PKKLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17661 S12 EPSD|PSP DES _________MSQAYSSsQRVssYRRtFGGAPGFPLGsPLss
P17661 S60 EPSD|PSP DES FGsKGssssVTSRVYQVSRtsGGAGGLGsLRAsRLGttRtP
P17661 T17 SIGNOR|ELM|iPTMNet|EPSD|PSP DES ____MSQAYSSsQRVssYRRtFGGAPGFPLGsPLssPVFPR
P17661 T76 SIGNOR|ELM|iPTMNet|EPSD|PSP DES VSRtsGGAGGLGsLRAsRLGttRtPssyGAGELLDFsLADA
P17661 T77 SIGNOR|ELM|iPTMNet|EPSD|PSP DES SRtsGGAGGLGsLRAsRLGttRtPssyGAGELLDFsLADAV
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18859 S57 Sugiyama ATP5PF ATP5A ATP5J ATPM DPIQKLFVDKIREYKSKRQTsGGPVDAssEyQQELERELFK
P19105 S19 GPS6|SIGNOR|ELM|iPTMNet|EPSD|Sugiyama MYL12A MLCB MRLC3 RLC __MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P19105 T18 GPS6|SIGNOR|ELM|iPTMNet|EPSD|Sugiyama MYL12A MLCB MRLC3 RLC ___MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19634 T653 EPSD|PSP SLC9A1 APNH1 NHE1 KILRNNLQKTRQRLRsyNRHtLVADPyEEAWNQMLLRRQKA
P23396 T70 Sugiyama RPS3 OK/SW-cl.26 ILATRTQNVLGEKGRRIRELtAVVQKRFGFPEGsVELyAEK
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P24844 S20 GPS6|SIGNOR|EPSD|PSP|Sugiyama MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P24844 T19 SIGNOR|EPSD|PSP|Sugiyama MYL9 MLC2 MRLC1 MYRL2 __MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26038 T558 SIGNOR|ELM|iPTMNet|EPSD|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26373 T24 Sugiyama RPL13 BBC1 OK/SW-cl.46 SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29474 T495 PSP NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29966 S159 EPSD|PSP MARCKS MACS PRKCSL EDGAtPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAG
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35241 T564 SIGNOR|ELM|iPTMNet|EPSD|PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35241 T573 SIGNOR|ELM|iPTMNet|EPSD RDX ENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM__________
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35611 T445 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ADD1 ADDA GDsGtCsPLRHsFQKQQREKtRWLNSGRGDEASEEGQNGss
P35611 T480 SIGNOR|ELM|EPSD|PSP ADD1 ADDA GQNGssPKsKTKWTKEDGHRtstsAVPNLFVPLNTNPKEVQ
P37108 T45 Sugiyama SRP14 sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P41181 T269 PSP AQP2 REVRRRQsVELHsPQsLPRGtKA__________________
P41567 T45 Sugiyama EIF1 SUI1 AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243 T150 Sugiyama MATR3 KIAA0723 EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778 T124 Sugiyama RPL21 sFLKRVKENDQKKKEAKEKGtWVQLKRQPAPPREAHFVRTN
P48436 S181 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SOX9 LRVQHKKDHPDYKYQPRRRKsVKNGQAEAEEATEQtHIsPN
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P50552 S157 GPS6|EPSD VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116 S504 Sugiyama FXR2 FMR1L2 PTGGRGRGPPPAPRPTSRYNsSsISSVLKDPDsNPYSLLDt
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P53667 T508 GPS6|SIGNOR|ELM|EPSD|PSP LIMK1 LIMK EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P53671 T505 GPS6|SIGNOR|ELM|EPSD|PSP LIMK2 MEKATTKKRtLRKNDRKKRYtVVGNPYWMAPEMLNGKSYDE
P53671 T526 SIGNOR|EPSD LIMK2 VVGNPYWMAPEMLNGKSYDEtVDIFSFGIVLCEIIGQVYAD
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60484 S229 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PTEN MMAC1 TEP1 GTCNPQFVVCQLKVKIYSSNsGPtRREDKFMyFEFPQPLPV
P60484 T232 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PTEN MMAC1 TEP1 NPQFVVCQLKVKIYSSNsGPtRREDKFMyFEFPQPLPVCGD
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61587 S11 SIGNOR|EPSD|PSP RND3 ARHE RHO8 RHOE __________MKERRAsQKLsSKsIMDPNQNVKCKIVVVGD
P61587 S218 EPSD|PSP RND3 ARHE RHO8 RHOE VNKTNKNVKRNKsQRATKRIsHMPSRPELSAVATDLRKDKA
P61587 S240 EPSD|PSP RND3 ARHE RHO8 RHOE MPSRPELSAVATDLRKDKAKsCTVM________________
P61587 S7 EPSD|PSP RND3 ARHE RHO8 RHOE ______________MKERRAsQKLsSKsIMDPNQNVKCKIV
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62081 S119 Sugiyama RPS7 RILPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEI
P62081 T121 Sugiyama RPS7 LPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVG
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62857 T28 Sugiyama RPS28 PIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsIIRNVKG
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68431 S11 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431 S29 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J RKstGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
P68431 T46 Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78316 S29 Sugiyama NOP14 C4orf9 NOL14 RES4-25 ARRKASGAPAGARGGPAKANsNPFEVKVNRQKFQILGRKTR
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P84243 T46 Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02543 T101 Sugiyama RPL18A WLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARHRARA
Q02878 T213 Sugiyama RPL6 TXREB1 FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05397 S732 GPS6|ELM|iPTMNet|EPSD|PSP PTK2 FAK FAK1 PPKPsRPGYPsPRSSEGFYPsPQHMVQTNHyQVSGYPGSHG
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442 T97 Sugiyama PDAP1 HASPP28 VEGLIDIENPNRVAQttKKVtQLDLDGPKELSRREREEIEK
Q13464 S118 Sugiyama ROCK1 TRKVYAMKLLSKFEMIKRSDsAFFWEERDIMAFANSPWVVQ
Q13464 S242 Sugiyama ROCK1 KMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDGYYGRECDWW
Q13464 S296 Sugiyama ROCK1 TPFYADSLVGTYSKIMNHKNsLTFPDDNDISKEAKNLICAF
Q13464 S407 Sugiyama ROCK1 FVGNQLPFVGFTYYSNRRYLsSANPNDNRTssNADKSLQES
Q13464 S417 Sugiyama ROCK1 FTYYSNRRYLsSANPNDNRTssNADKSLQESLQKTIYKLEE
Q13464 S418 Sugiyama ROCK1 TYYSNRRYLsSANPNDNRTssNADKSLQESLQKTIYKLEEQ
Q13464 T219 Sugiyama ROCK1 VKPDNMLLDKSGHLKLADFGtCMKMNKEGMVRCDtAVGtPD
Q13464 T233 Sugiyama ROCK1 KLADFGtCMKMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDG
Q13464 T237 Sugiyama ROCK1 FGtCMKMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDGYYGR
Q13464 Y240 Sugiyama ROCK1 CMKMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDGYYGRECD
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14160 S1378 EPSD|PSP SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL QKyFELEVRVPQAEGPPKRVsLVGADDLRKMQEEEARKLQQ
Q14160 S1508 EPSD|PSP SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL AELRALEAEKRALWRAARMKsLEQDALRAQMVLSRsQEGRG
Q14192 S257 Sugiyama FHL2 DRAL SLIM3 IsFEERQWHNDCFNCKKCsLsLVGRGFLTERDDILCPDCGK
Q14204 T695 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 NHVEGQKLKQDGDsFRMKLNtQEIFDDWARKVQQRNLGVSG
Q14247 T401 Sugiyama CTTN EMS1 RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14432 S312 Sugiyama PDE3A sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14CB8 S422 EPSD|PSP ARHGAP19 TQtPGREPSTSQVQKRARsRsFSGLIKRKVLGNQMMsEKKK
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q16555 T555 SIGNOR|ELM|iPTMNet|EPSD|PSP DPYSL2 CRMP2 ULIP2 HQsGFsLsGAQIDDNIPRRTtQRIVAPPGGRANITSLG___
Q16695 T46 Sugiyama H3-4 H3FT HIST3H3 ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6FI81 T250 Sugiyama CIAPIN1 CUA001 PRO0915 ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6NXT2 T45 Sugiyama H3-5 H3F3C AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6QNY0 T16 Sugiyama BLOC1S3 BLOS3 _____MASQGRRRRPLRRPEtVVPGEAtEtDsERsAsssEE
Q71DI3 T46 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N264 S391 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP SRQCSWDKSESPQRSSMNNGsPTALSGSKTNsPKNSVHKLD
Q8N264 S402 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP PQRSSMNNGsPTALSGSKTNsPKNSVHKLDVsRsPPLMVKK
Q8N264 S413 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP TALSGSKTNsPKNSVHKLDVsRsPPLMVKKNPAFNKGSGIV
Q8N264 S415 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP LSGSKTNsPKNSVHKLDVsRsPPLMVKKNPAFNKGSGIVTN
Q8N264 S437 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP PLMVKKNPAFNKGSGIVTNGsFSSSNAEGLEKTQTtPNGSL
Q8N264 S573 SIGNOR|iPTMNet|EPSD ARHGAP24 FILGAP ATWSTSSCEISLPENSNSCRsstttCPEQDFFGGNFEDPVL
Q8N264 S574 SIGNOR|iPTMNet|EPSD ARHGAP24 FILGAP TWSTSSCEISLPENSNSCRsstttCPEQDFFGGNFEDPVLD
Q8N264 T452 SIGNOR|iPTMNet|EPSD|PSP ARHGAP24 FILGAP IVTNGsFSSSNAEGLEKTQTtPNGSLQARRSSSLKVSGTKM
Q8N264 T575 SIGNOR|iPTMNet|EPSD ARHGAP24 FILGAP WSTSSCEISLPENSNSCRsstttCPEQDFFGGNFEDPVLDG
Q8N264 T576 SIGNOR|iPTMNet|EPSD ARHGAP24 FILGAP STSSCEISLPENSNSCRsstttCPEQDFFGGNFEDPVLDGP
Q8N264 T577 SIGNOR|iPTMNet|EPSD ARHGAP24 FILGAP TSSCEISLPENSNSCRsstttCPEQDFFGGNFEDPVLDGPP
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WWI1 T932 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96IZ0 S162 Sugiyama PAWR PAR4 PSARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEA
Q96IZ0 T163 PSP|Sugiyama PAWR PAR4 SARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEAG
Q96JX3 S450 Sugiyama SERAC1 YTTCWPKTWLAKDCPALRIIsVEYDtSLSDWRARCPMERKS
Q96JX3 T455 Sugiyama SERAC1 PKTWLAKDCPALRIIsVEYDtSLSDWRARCPMERKSIAFRS
Q99755 S479 Sugiyama PIP5K1A PsKKFRSGssFSRRAGssGNsCItyQPsVsGEHKAQVTTKA
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9HAU0 S471 Sugiyama PLEKHA5 KIAA1686 PEPP2 MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK
Q9NRY4 S1150 SIGNOR|EPSD|PSP ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP sGNGsDsEMDTssLERGRKVsIVSKPVLYRTRCTRLGRFAS
Q9NRY4 S1174 EPSD|PSP ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP KPVLYRTRCTRLGRFASYRtsFsVGsDDELGPIRKKEEDQA
Q9NRY4 S1236 SIGNOR|EPSD|PSP ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP RNILRsLRRNtKKPKPKPRPsITKATWESNYFGVPLTTVVT
Q9NRY4 T1173 EPSD|PSP ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP SKPVLYRTRCTRLGRFASYRtsFsVGsDDELGPIRKKEEDQ
Q9NRY4 T1226 SIGNOR|EPSD|PSP ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP PYETDEDPRRRNILRsLRRNtKKPKPKPRPsITKATWESNY
Q9UPT6 S314 GPS6|SIGNOR|EPSD|PSP MAPK8IP3 JIP3 KIAA1066 PLGDYGVGSKNSKRAREKRDsRNMEVQVTQEMRNVSIGMGS
Q9UPT6 S364 GPS6|SIGNOR|EPSD|PSP MAPK8IP3 JIP3 KIAA1066 IIDSTPELDMCPETRLDRtGssPtQGIVNKAFGINTDSLYH
Q9UPT6 S365 GPS6|SIGNOR|EPSD|PSP MAPK8IP3 JIP3 KIAA1066 IDSTPELDMCPETRLDRtGssPtQGIVNKAFGINTDSLYHE
Q9UQ35 S1455 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 S854 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2W1 S379 Sugiyama THRAP3 BCLAF2 TRAP150 DKEQKQTNTDKEKIKEKGsFsDtGLGDGKMKSDsFAPKtDs
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5U2 S109 Sugiyama TSSC4 FSQRsRDIFDCLEGAARRAPsSVAHTSMSDNGGFKRPLAPs
Q9Y613 S1131 SIGNOR|EPSD|PSP FHOD1 FHOS FHOS1 LVQSVTKSSPRALAARERKRsRGNRKsLRRtLKSGLGDDLV
Q9Y613 S1137 SIGNOR|EPSD|PSP FHOD1 FHOS FHOS1 KSSPRALAARERKRsRGNRKsLRRtLKSGLGDDLVQALGLS
Q9Y613 T1141 SIGNOR|EPSD|PSP FHOD1 FHOS FHOS1 RALAARERKRsRGNRKsLRRtLKSGLGDDLVQALGLSKGPG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cellular Senescence R-HSA-2559583 4.696243e-14 13.328 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.284373e-12 11.082 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.684508e-11 10.774 0 0
Meiotic synapsis R-HSA-1221632 3.027634e-11 10.519 0 0
Meiosis R-HSA-1500620 4.332679e-11 10.363 0 0
Cell Cycle R-HSA-1640170 1.461153e-10 9.835 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.963303e-10 9.707 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.418618e-10 9.616 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.873771e-10 9.542 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.968905e-10 9.401 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.755243e-10 9.323 0 0
Reproduction R-HSA-1474165 8.374038e-10 9.077 0 0
Packaging Of Telomere Ends R-HSA-171306 1.113349e-09 8.953 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.113349e-09 8.953 0 0
Signal Transduction R-HSA-162582 1.171374e-09 8.931 1 0
ESR-mediated signaling R-HSA-8939211 1.228120e-09 8.911 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.661786e-09 8.779 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.019106e-09 8.695 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.019106e-09 8.695 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.947479e-09 8.711 0 0
DNA methylation R-HSA-5334118 2.329570e-09 8.633 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.229504e-09 8.652 0 0
Diseases of programmed cell death R-HSA-9645723 2.855857e-09 8.544 0 0
Cell Cycle Checkpoints R-HSA-69620 3.101870e-09 8.508 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.393801e-09 8.469 0 0
Meiotic recombination R-HSA-912446 5.971486e-09 8.224 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.481086e-09 8.188 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.933875e-09 8.049 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.028816e-08 7.988 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.134316e-08 7.945 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.652095e-08 7.782 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.061561e-08 7.686 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.755953e-08 7.560 0 0
Cell Cycle, Mitotic R-HSA-69278 2.799457e-08 7.553 0 0
Defective pyroptosis R-HSA-9710421 3.553781e-08 7.449 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.676175e-08 7.435 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.906719e-08 7.408 0 0
Cleavage of the damaged purine R-HSA-110331 3.906719e-08 7.408 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.086199e-08 7.389 0 0
Depurination R-HSA-73927 5.127762e-08 7.290 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.219532e-08 7.141 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.219532e-08 7.141 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.655434e-08 7.063 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.239070e-07 6.907 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.366693e-07 6.864 0 0
Cell junction organization R-HSA-446728 1.620463e-07 6.790 0 0
DNA Double Strand Break Response R-HSA-5693606 1.773538e-07 6.751 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.811233e-07 6.742 0 0
Depyrimidination R-HSA-73928 1.811233e-07 6.742 0 0
Mitotic Prophase R-HSA-68875 1.852468e-07 6.732 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.276851e-07 6.643 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.399436e-07 6.469 0 0
M Phase R-HSA-68886 3.759796e-07 6.425 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.005268e-07 6.397 0 0
Apoptotic execution phase R-HSA-75153 4.486665e-07 6.348 1 0
HDACs deacetylate histones R-HSA-3214815 5.063715e-07 6.296 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.493567e-07 6.188 0 0
Signaling by Interleukins R-HSA-449147 6.714566e-07 6.173 0 0
Cell-cell junction organization R-HSA-421270 1.137282e-06 5.944 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.519370e-06 5.818 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.488161e-06 5.827 0 0
Adherens junctions interactions R-HSA-418990 1.765136e-06 5.753 0 0
Amyloid fiber formation R-HSA-977225 1.784395e-06 5.749 0 0
HATs acetylate histones R-HSA-3214847 1.929549e-06 5.715 0 0
Nucleosome assembly R-HSA-774815 2.087603e-06 5.680 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.087603e-06 5.680 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.208537e-06 5.656 0 0
Cell-Cell communication R-HSA-1500931 2.621372e-06 5.581 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.695582e-06 5.569 1 1
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.756802e-06 5.560 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.640982e-06 5.439 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.088651e-06 5.388 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.088651e-06 5.388 0 0
Chromatin modifying enzymes R-HSA-3247509 6.198461e-06 5.208 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.238269e-06 5.205 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.628884e-06 5.118 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.628884e-06 5.118 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.829069e-06 5.054 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.119388e-06 5.040 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.326862e-06 5.030 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.211095e-05 4.917 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.280091e-05 4.893 0 0
Developmental Biology R-HSA-1266738 1.688751e-05 4.772 1 0
RNA Polymerase II Transcription R-HSA-73857 1.725600e-05 4.763 0 0
Chromatin organization R-HSA-4839726 1.805997e-05 4.743 0 0
Telomere Maintenance R-HSA-157579 2.122213e-05 4.673 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.233510e-05 4.651 0 0
Homology Directed Repair R-HSA-5693538 2.394498e-05 4.621 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.624347e-05 4.581 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.786878e-05 4.555 0 0
Signaling by WNT R-HSA-195721 2.880024e-05 4.541 0 0
Chromosome Maintenance R-HSA-73886 3.226563e-05 4.491 0 0
Axon guidance R-HSA-422475 4.237505e-05 4.373 1 0
Semaphorin interactions R-HSA-373755 4.366631e-05 4.360 1 0
Ub-specific processing proteases R-HSA-5689880 5.902017e-05 4.229 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.101271e-05 4.215 0 0
G2/M Checkpoints R-HSA-69481 6.244657e-05 4.204 0 0
RNA Polymerase I Transcription R-HSA-73864 7.794046e-05 4.108 0 0
FOXO-mediated transcription R-HSA-9614085 9.101846e-05 4.041 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.072924e-04 3.969 0 0
Generic Transcription Pathway R-HSA-212436 1.096225e-04 3.960 0 0
Cellular responses to stimuli R-HSA-8953897 1.198099e-04 3.922 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.232259e-04 3.909 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.564545e-04 3.806 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.564545e-04 3.806 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.564545e-04 3.806 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.472027e-04 3.832 0 0
Nervous system development R-HSA-9675108 1.876611e-04 3.727 1 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.931328e-04 3.714 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.931328e-04 3.714 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.962965e-04 3.707 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.310471e-04 3.636 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.369368e-04 3.625 0 0
RET signaling R-HSA-8853659 2.444668e-04 3.612 0 0
Cellular responses to stress R-HSA-2262752 2.794666e-04 3.554 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.807070e-04 3.552 0 0
Gene expression (Transcription) R-HSA-74160 3.129632e-04 3.505 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.222255e-04 3.492 0 0
Base Excision Repair R-HSA-73884 3.231575e-04 3.491 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.386625e-04 3.470 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.391480e-04 3.470 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.702146e-04 3.432 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.200075e-04 3.284 1 1
PKMTs methylate histone lysines R-HSA-3214841 5.363233e-04 3.271 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.408897e-04 3.267 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.282219e-04 3.202 0 0
Gene Silencing by RNA R-HSA-211000 6.527753e-04 3.185 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.605958e-04 3.180 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.594576e-04 3.119 1 0
Deubiquitination R-HSA-5688426 7.688026e-04 3.114 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.703666e-04 3.113 0 0
MAPK family signaling cascades R-HSA-5683057 7.805330e-04 3.108 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.348518e-04 3.078 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.052321e-03 2.978 0 0
Signaling by LTK R-HSA-9842663 1.055701e-03 2.976 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.060083e-03 2.975 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.071797e-03 2.970 0 0
Signaling by VEGF R-HSA-194138 1.209252e-03 2.917 1 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.303936e-03 2.885 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.316846e-03 2.880 1 1
Mitotic Prometaphase R-HSA-68877 1.365444e-03 2.865 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.773486e-03 2.751 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.946908e-03 2.711 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.129368e-03 2.672 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.153696e-03 2.667 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.224062e-03 2.653 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.227145e-03 2.652 0 0
Mitotic Anaphase R-HSA-68882 2.230936e-03 2.652 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.345978e-03 2.630 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.375492e-03 2.624 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.999616e-03 2.523 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.745668e-03 2.561 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.999616e-03 2.523 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.999616e-03 2.523 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.764788e-03 2.558 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.236839e-03 2.490 0 0
Neurodegenerative Diseases R-HSA-8863678 3.236839e-03 2.490 0 0
Ion homeostasis R-HSA-5578775 3.728307e-03 2.428 0 0
HDMs demethylate histones R-HSA-3214842 3.790655e-03 2.421 0 0
Muscle contraction R-HSA-397014 3.862883e-03 2.413 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.003293e-03 2.398 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.116721e-03 2.385 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.239313e-03 2.373 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.601793e-03 2.337 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.104824e-03 2.292 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.191775e-03 2.285 0 0
Signaling by ERBB2 R-HSA-1227986 5.473864e-03 2.262 0 0
Co-stimulation by CD28 R-HSA-389356 5.549657e-03 2.256 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.601538e-03 2.252 0 0
Separation of Sister Chromatids R-HSA-2467813 6.544968e-03 2.184 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.212117e-03 2.207 0 0
Programmed Cell Death R-HSA-5357801 5.731257e-03 2.242 1 0
Apoptosis R-HSA-109581 5.900404e-03 2.229 1 0
Rap1 signalling R-HSA-392517 5.919028e-03 2.228 0 0
Activation of RAC1 R-HSA-428540 5.816540e-03 2.235 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.874491e-03 2.231 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.636830e-03 2.178 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.636830e-03 2.178 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.645730e-03 2.177 0 0
Interleukin-12 signaling R-HSA-9020591 7.187058e-03 2.143 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.275085e-03 2.138 1 0
IGF1R signaling cascade R-HSA-2428924 7.792973e-03 2.108 0 0
DNA Replication R-HSA-69306 8.052337e-03 2.094 0 0
mRNA 3'-end processing R-HSA-72187 8.217563e-03 2.085 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.217563e-03 2.085 0 0
G alpha (12/13) signalling events R-HSA-416482 8.384417e-03 2.077 1 1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.475077e-03 2.072 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.733453e-03 2.059 0 0
Co-inhibition by PD-1 R-HSA-389948 8.845740e-03 2.053 0 0
Formation of axial mesoderm R-HSA-9796292 8.923237e-03 2.049 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 9.001955e-03 2.046 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.365901e-03 2.028 0 0
Signaling by ROBO receptors R-HSA-376176 1.009240e-02 1.996 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.079469e-02 1.967 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.132102e-02 1.946 0 0
Regulation of TP53 Activity R-HSA-5633007 1.141537e-02 1.943 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.210369e-02 1.917 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.210369e-02 1.917 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.352449e-02 1.869 0 0
Netrin-1 signaling R-HSA-373752 1.239045e-02 1.907 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.258627e-02 1.900 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.298212e-02 1.887 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.263402e-02 1.898 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.380994e-02 1.860 0 0
DNA Repair R-HSA-73894 1.433699e-02 1.844 0 0
HCMV Early Events R-HSA-9609690 1.471281e-02 1.832 0 0
Signaling by TGFBR3 R-HSA-9839373 1.492401e-02 1.826 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.533550e-02 1.814 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.533550e-02 1.814 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.551887e-02 1.809 0 0
Potassium transport channels R-HSA-1296067 1.551887e-02 1.809 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.567602e-02 1.805 0 0
Interleukin-12 family signaling R-HSA-447115 1.680592e-02 1.775 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.759261e-02 1.755 0 0
Death Receptor Signaling R-HSA-73887 1.781100e-02 1.749 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.798027e-02 1.745 0 0
Protein ubiquitination R-HSA-8852135 1.802396e-02 1.744 0 0
TRP channels R-HSA-3295583 1.847505e-02 1.733 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.953615e-02 1.709 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.953615e-02 1.709 0 0
HCMV Late Events R-HSA-9610379 2.038372e-02 1.691 0 0
Specification of primordial germ cells R-HSA-9827857 2.089198e-02 1.680 0 0
mRNA Splicing R-HSA-72172 2.110317e-02 1.676 0 0
Sensory processing of sound R-HSA-9659379 2.347043e-02 1.629 0 0
Signaling by NOTCH R-HSA-157118 2.353749e-02 1.628 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.407682e-02 1.618 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.826098e-02 1.549 0 0
Polo-like kinase mediated events R-HSA-156711 2.407682e-02 1.618 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.499759e-02 1.602 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.400884e-02 1.620 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.407682e-02 1.618 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.400884e-02 1.620 0 0
EPH-Ephrin signaling R-HSA-2682334 2.420021e-02 1.616 1 0
FLT3 Signaling R-HSA-9607240 2.718354e-02 1.566 0 0
Interleukin-37 signaling R-HSA-9008059 2.868915e-02 1.542 0 0
Ephrin signaling R-HSA-3928664 2.407682e-02 1.618 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.709373e-02 1.567 0 0
Signaling by ALK in cancer R-HSA-9700206 2.709373e-02 1.567 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.122179e-02 1.506 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.128486e-02 1.505 0 0
Formation of definitive endoderm R-HSA-9823730 3.128486e-02 1.505 0 0
Immune System R-HSA-168256 3.183651e-02 1.497 1 0
TNFR1-mediated ceramide production R-HSA-5626978 3.284691e-02 1.484 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.284691e-02 1.484 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.284691e-02 1.484 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.284691e-02 1.484 0 0
Dopamine receptors R-HSA-390651 3.284691e-02 1.484 0 0
NRAGE signals death through JNK R-HSA-193648 3.324209e-02 1.478 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.324209e-02 1.478 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.369948e-02 1.472 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.446851e-02 1.463 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.446851e-02 1.463 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.446851e-02 1.463 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.491002e-02 1.457 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.491002e-02 1.457 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.726946e-02 1.429 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.770241e-02 1.424 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.782247e-02 1.422 0 0
G-protein beta:gamma signalling R-HSA-397795 3.830936e-02 1.417 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.958396e-02 1.402 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.044556e-02 1.393 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.044556e-02 1.393 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.044556e-02 1.393 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.044556e-02 1.393 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.044556e-02 1.393 0 0
Repression of WNT target genes R-HSA-4641265 4.044556e-02 1.393 0 0
NrCAM interactions R-HSA-447038 4.337057e-02 1.363 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.423439e-02 1.354 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.580491e-02 1.339 0 0
Developmental Cell Lineages R-HSA-9734767 4.887925e-02 1.311 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.690932e-02 1.329 0 0
HCMV Infection R-HSA-9609646 5.561890e-02 1.255 0 0
Recycling pathway of L1 R-HSA-437239 4.718850e-02 1.326 0 0
GPER1 signaling R-HSA-9634597 5.063060e-02 1.296 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.612143e-02 1.336 0 0
Calmodulin induced events R-HSA-111933 5.387268e-02 1.269 0 0
S Phase R-HSA-69242 5.297853e-02 1.276 0 0
CaM pathway R-HSA-111997 5.387268e-02 1.269 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.773616e-02 1.321 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.495921e-02 1.260 0 0
Cardiac conduction R-HSA-5576891 4.783179e-02 1.320 0 0
Adaptive Immune System R-HSA-1280218 5.003105e-02 1.301 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.690932e-02 1.329 0 0
HDL assembly R-HSA-8963896 5.384818e-02 1.269 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.825901e-02 1.235 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.906300e-02 1.229 0 0
TGFBR3 expression R-HSA-9839394 5.975899e-02 1.224 0 0
Formation of the nephric duct R-HSA-9830364 5.975899e-02 1.224 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.124848e-02 1.213 0 0
Formation of the anterior neural plate R-HSA-9823739 6.124848e-02 1.213 0 0
G2/M Transition R-HSA-69275 6.355015e-02 1.197 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.749346e-02 1.171 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.749346e-02 1.171 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.749346e-02 1.171 0 0
Signaling by ALK R-HSA-201556 6.762572e-02 1.170 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.773604e-02 1.169 0 0
Smooth Muscle Contraction R-HSA-445355 7.009785e-02 1.154 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.145455e-02 1.146 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.151331e-02 1.146 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.151331e-02 1.146 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.151331e-02 1.146 0 0
Generation of second messenger molecules R-HSA-202433 7.260424e-02 1.139 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.951438e-02 1.048 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.951438e-02 1.048 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.951438e-02 1.048 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.951438e-02 1.048 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.951438e-02 1.048 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.951438e-02 1.048 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.951438e-02 1.048 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.951438e-02 1.048 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 8.086262e-02 1.092 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.086262e-02 1.092 0 0
FGFR1b ligand binding and activation R-HSA-190370 9.496415e-02 1.022 0 0
Activation of RAS in B cells R-HSA-1169092 9.496415e-02 1.022 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.513634e-02 1.022 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.435380e-02 1.074 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.435380e-02 1.074 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 9.116775e-02 1.040 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.016202e-02 1.045 0 0
Centrosome maturation R-HSA-380287 9.914226e-02 1.004 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.536076e-02 1.123 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.435380e-02 1.074 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.116775e-02 1.040 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.737046e-02 1.111 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.358511e-02 1.078 0 0
Adrenoceptors R-HSA-390696 9.496415e-02 1.022 0 0
DARPP-32 events R-HSA-180024 8.435380e-02 1.074 0 0
Signaling by FGFR4 R-HSA-5654743 9.444608e-02 1.025 0 0
TNF signaling R-HSA-75893 8.358511e-02 1.078 0 0
Signaling by FGFR1 R-HSA-5654736 8.358511e-02 1.078 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 9.496415e-02 1.022 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 9.496415e-02 1.022 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 9.496415e-02 1.022 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.116775e-02 1.040 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.116775e-02 1.040 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.837873e-02 1.054 0 0
Inhibition of PKR R-HSA-169131 8.951438e-02 1.048 0 0
PKA activation R-HSA-163615 9.513634e-02 1.022 0 0
PKA activation in glucagon signalling R-HSA-164378 9.513634e-02 1.022 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.737046e-02 1.111 0 0
Signaling by Hippo R-HSA-2028269 8.605729e-02 1.065 0 0
Amine ligand-binding receptors R-HSA-375280 1.003763e-01 0.998 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.605729e-02 1.065 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.691259e-02 1.114 0 0
Pyroptosis R-HSA-5620971 7.780035e-02 1.109 0 0
Ca-dependent events R-HSA-111996 8.870100e-02 1.052 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.759070e-02 1.110 0 0
Glycolysis R-HSA-70171 8.154174e-02 1.089 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.086262e-02 1.092 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 8.086262e-02 1.092 0 0
L1CAM interactions R-HSA-373760 8.977971e-02 1.047 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.496415e-02 1.022 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.003763e-01 0.998 1 1
Glucose metabolism R-HSA-70326 9.318681e-02 1.031 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.816039e-02 1.107 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.021078e-01 0.991 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.022715e-01 0.990 0 0
Kinesins R-HSA-983189 1.036362e-01 0.984 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.045879e-01 0.981 0 0
Specification of the neural plate border R-HSA-9834899 1.045879e-01 0.981 0 0
G0 and Early G1 R-HSA-1538133 1.055505e-01 0.977 0 0
Inwardly rectifying K+ channels R-HSA-1296065 1.055505e-01 0.977 0 0
Signaling by WNT in cancer R-HSA-4791275 1.055505e-01 0.977 0 0
Signaling by FGFR3 R-HSA-5654741 1.064882e-01 0.973 0 0
DAG and IP3 signaling R-HSA-1489509 1.064882e-01 0.973 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.090087e-01 0.963 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.097031e-01 0.960 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.097031e-01 0.960 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.097031e-01 0.960 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.127785e-01 0.948 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.127785e-01 0.948 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.127785e-01 0.948 0 0
Signaling by RAS mutants R-HSA-6802949 1.127785e-01 0.948 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.127785e-01 0.948 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.131048e-01 0.947 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.131048e-01 0.947 0 0
Integrin signaling R-HSA-354192 1.131048e-01 0.947 0 0
Cardiogenesis R-HSA-9733709 1.131048e-01 0.947 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.134943e-01 0.945 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.143915e-01 0.942 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.143915e-01 0.942 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.143915e-01 0.942 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.143915e-01 0.942 0 0
Signaling by NODAL R-HSA-1181150 1.143915e-01 0.942 0 0
Protein hydroxylation R-HSA-9629569 1.143915e-01 0.942 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.312241e-01 0.882 0 0
Intestinal infectious diseases R-HSA-8942233 1.312241e-01 0.882 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.312241e-01 0.882 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.312241e-01 0.882 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.312241e-01 0.882 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 1.312241e-01 0.882 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.312241e-01 0.882 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.312241e-01 0.882 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.312241e-01 0.882 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.312241e-01 0.882 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.710256e-01 0.767 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.710256e-01 0.767 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.710256e-01 0.767 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.710256e-01 0.767 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.710256e-01 0.767 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.710256e-01 0.767 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.710256e-01 0.767 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.710256e-01 0.767 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.249917e-01 0.903 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.249917e-01 0.903 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.407488e-01 0.852 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.568995e-01 0.804 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.568995e-01 0.804 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.568995e-01 0.804 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.568995e-01 0.804 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.733750e-01 0.761 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.733750e-01 0.761 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.733750e-01 0.761 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.733750e-01 0.761 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.733750e-01 0.761 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.245265e-01 0.905 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.245265e-01 0.905 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.245265e-01 0.905 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.349718e-01 0.870 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.349718e-01 0.870 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 1.349718e-01 0.870 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.567087e-01 0.805 0 0
Striated Muscle Contraction R-HSA-390522 1.208904e-01 0.918 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.679580e-01 0.775 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.679580e-01 0.775 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.541757e-01 0.812 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.540288e-01 0.812 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.614449e-01 0.792 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.614449e-01 0.792 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.379267e-01 0.860 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.371224e-01 0.863 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.371224e-01 0.863 0 0
Signal attenuation R-HSA-74749 1.249917e-01 0.903 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.249917e-01 0.903 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.719757e-01 0.765 0 0
Insulin receptor signalling cascade R-HSA-74751 1.259581e-01 0.900 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.288992e-01 0.890 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.567087e-01 0.805 0 0
Formation of the posterior neural plate R-HSA-9832991 1.407488e-01 0.852 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.733750e-01 0.761 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.158696e-01 0.936 0 0
Signalling to ERKs R-HSA-187687 1.371224e-01 0.863 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.208904e-01 0.918 0 0
Interleukin-2 signaling R-HSA-9020558 1.407488e-01 0.852 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.407488e-01 0.852 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.245265e-01 0.905 0 0
Regulated Necrosis R-HSA-5218859 1.504047e-01 0.823 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 1.710256e-01 0.767 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.710256e-01 0.767 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.407488e-01 0.852 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.288992e-01 0.890 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.629871e-01 0.788 0 0
PI3K Cascade R-HSA-109704 1.396405e-01 0.855 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.201720e-01 0.920 0 0
Signaling by TGFB family members R-HSA-9006936 1.372718e-01 0.862 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.679580e-01 0.775 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.371224e-01 0.863 0 0
Oncogene Induced Senescence R-HSA-2559585 1.371224e-01 0.863 0 0
Post NMDA receptor activation events R-HSA-438064 1.685053e-01 0.773 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.733750e-01 0.761 0 0
Interleukin-15 signaling R-HSA-8983432 1.733750e-01 0.761 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.394053e-01 0.856 0 0
Signaling by PTK6 R-HSA-8848021 1.201720e-01 0.920 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.201720e-01 0.920 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.312241e-01 0.882 0 0
DSCAM interactions R-HSA-376172 1.710256e-01 0.767 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.249917e-01 0.903 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.349718e-01 0.870 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.457063e-01 0.837 0 0
Estrogen biosynthesis R-HSA-193144 1.733750e-01 0.761 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.288992e-01 0.890 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.540288e-01 0.812 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.389103e-01 0.857 0 0
Stimuli-sensing channels R-HSA-2672351 1.158696e-01 0.936 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.349718e-01 0.870 0 0
Plasma lipoprotein assembly R-HSA-8963898 1.679580e-01 0.775 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.772264e-01 0.751 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.794333e-01 0.746 0 0
Tight junction interactions R-HSA-420029 1.794333e-01 0.746 0 0
Interleukin-7 signaling R-HSA-1266695 1.794333e-01 0.746 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.801394e-01 0.744 0 0
Interleukin-1 family signaling R-HSA-446652 1.801394e-01 0.744 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.811317e-01 0.742 0 0
HIV Transcription Elongation R-HSA-167169 1.811317e-01 0.742 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.811317e-01 0.742 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.811317e-01 0.742 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.811317e-01 0.742 0 0
Ca2+ pathway R-HSA-4086398 1.836617e-01 0.736 0 0
Signaling by EGFR R-HSA-177929 1.845166e-01 0.734 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.090059e-01 0.680 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.090059e-01 0.680 0 0
Invadopodia formation R-HSA-8941237 2.090059e-01 0.680 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.452483e-01 0.610 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.452483e-01 0.610 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.452483e-01 0.610 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.452483e-01 0.610 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.798322e-01 0.553 0 0
IRS activation R-HSA-74713 2.798322e-01 0.553 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.798322e-01 0.553 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.798322e-01 0.553 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.798322e-01 0.553 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.798322e-01 0.553 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.798322e-01 0.553 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.128335e-01 0.505 0 0
PDE3B signalling R-HSA-165160 3.128335e-01 0.505 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.128335e-01 0.505 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.128335e-01 0.505 0 0
PKB-mediated events R-HSA-109703 3.128335e-01 0.505 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.128335e-01 0.505 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.128335e-01 0.505 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.128335e-01 0.505 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.901116e-01 0.721 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.901116e-01 0.721 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.070510e-01 0.684 0 0
STAT5 Activation R-HSA-9645135 3.443243e-01 0.463 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.443243e-01 0.463 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.241396e-01 0.649 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.241396e-01 0.649 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.241396e-01 0.649 0 0
Phosphorylation of the APC/C R-HSA-176412 2.413282e-01 0.617 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.413282e-01 0.617 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.743739e-01 0.427 0 0
Netrin mediated repulsion signals R-HSA-418886 3.743739e-01 0.427 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.743739e-01 0.427 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.743739e-01 0.427 0 0
Disinhibition of SNARE formation R-HSA-114516 3.743739e-01 0.427 0 0
SOS-mediated signalling R-HSA-112412 3.743739e-01 0.427 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.743739e-01 0.427 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.743739e-01 0.427 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.585719e-01 0.587 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.029796e-01 0.693 1 1
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.029796e-01 0.693 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.029796e-01 0.693 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.029796e-01 0.693 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.758297e-01 0.559 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.758297e-01 0.559 0 0
HIV elongation arrest and recovery R-HSA-167287 2.150104e-01 0.668 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.150104e-01 0.668 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.271868e-01 0.644 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.102411e-01 0.508 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.102411e-01 0.508 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.095051e-01 0.679 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.769773e-01 0.558 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.896083e-01 0.538 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.490788e-01 0.604 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.611336e-01 0.442 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.611336e-01 0.442 0 0
RAF activation R-HSA-5673000 3.022797e-01 0.520 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.424170e-01 0.615 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.424170e-01 0.615 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.657255e-01 0.437 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.301986e-01 0.638 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.301986e-01 0.638 0 0
Translation initiation complex formation R-HSA-72649 3.318822e-01 0.479 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.889805e-01 0.539 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.529212e-01 0.452 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.050396e-01 0.516 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.443024e-01 0.463 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.443024e-01 0.463 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.758297e-01 0.559 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.758297e-01 0.559 0 0
Telomere Extension By Telomerase R-HSA-171319 2.150104e-01 0.668 0 0
EGFR downregulation R-HSA-182971 2.519010e-01 0.599 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.029796e-01 0.693 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.102411e-01 0.508 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.999063e-01 0.699 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.273299e-01 0.485 0 0
Frs2-mediated activation R-HSA-170968 1.901116e-01 0.721 0 0
Signaling by FGFR R-HSA-190236 2.536996e-01 0.596 0 0
MAP2K and MAPK activation R-HSA-5674135 1.999063e-01 0.699 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.043491e-01 0.517 0 0
Myogenesis R-HSA-525793 1.911140e-01 0.719 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.930641e-01 0.533 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.644026e-01 0.578 0 0
Signaling by FGFR2 R-HSA-5654738 2.344636e-01 0.630 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.241396e-01 0.649 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.241396e-01 0.649 0 0
Trafficking of AMPA receptors R-HSA-399719 2.519010e-01 0.599 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.134057e-01 0.504 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.134057e-01 0.504 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.585719e-01 0.587 0 0
Signalling to RAS R-HSA-167044 3.443024e-01 0.463 0 0
Prolonged ERK activation events R-HSA-169893 2.413282e-01 0.617 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.930641e-01 0.533 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.901116e-01 0.721 0 0
mRNA Editing: C to U Conversion R-HSA-72200 3.743739e-01 0.427 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.743739e-01 0.427 0 0
IRS-mediated signalling R-HSA-112399 1.924629e-01 0.716 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.443024e-01 0.463 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.316174e-01 0.479 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.877852e-01 0.726 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.999063e-01 0.699 0 0
DAP12 signaling R-HSA-2424491 2.394898e-01 0.621 0 0
Cyclin D associated events in G1 R-HSA-69231 2.290760e-01 0.640 0 0
G1 Phase R-HSA-69236 2.290760e-01 0.640 0 0
Neurexins and neuroligins R-HSA-6794361 3.109094e-01 0.507 0 0
Signaling by FGFR in disease R-HSA-1226099 3.407613e-01 0.468 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.896083e-01 0.538 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.452483e-01 0.610 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.798322e-01 0.553 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.798322e-01 0.553 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.241396e-01 0.649 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.758297e-01 0.559 0 0
RMTs methylate histone arginines R-HSA-3214858 2.290760e-01 0.640 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.467143e-01 0.608 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.911140e-01 0.719 0 0
Signaling by Insulin receptor R-HSA-74752 3.457869e-01 0.461 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.769773e-01 0.558 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.443243e-01 0.463 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.930641e-01 0.533 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.273299e-01 0.485 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.896083e-01 0.538 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.102411e-01 0.508 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.397902e-01 0.620 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.407613e-01 0.468 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.769773e-01 0.558 0 0
Gastrulation R-HSA-9758941 2.617659e-01 0.582 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.452483e-01 0.610 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.798322e-01 0.553 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.798322e-01 0.553 0 0
Synthesis of PS R-HSA-1483101 3.128335e-01 0.505 0 0
Formation of the Editosome R-HSA-75094 3.128335e-01 0.505 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.128335e-01 0.505 0 0
Phosphorylation of Emi1 R-HSA-176417 3.128335e-01 0.505 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.901116e-01 0.721 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.901116e-01 0.721 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.443243e-01 0.463 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.930641e-01 0.533 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.271868e-01 0.644 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.639426e-01 0.439 0 0
GPCR downstream signalling R-HSA-388396 2.878447e-01 0.541 1 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.704854e-01 0.431 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.769773e-01 0.558 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.743739e-01 0.427 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.731081e-01 0.564 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.743739e-01 0.427 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.821904e-01 0.549 0 0
Cellular response to chemical stress R-HSA-9711123 2.008944e-01 0.697 0 0
Regulation of BACH1 activity R-HSA-9708530 2.413282e-01 0.617 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.911140e-01 0.719 0 0
Opioid Signalling R-HSA-111885 2.967220e-01 0.528 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.150104e-01 0.668 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.271868e-01 0.644 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.022797e-01 0.520 0 0
Potassium Channels R-HSA-1296071 2.397902e-01 0.620 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.090059e-01 0.680 0 0
NADE modulates death signalling R-HSA-205025 2.452483e-01 0.610 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.798322e-01 0.553 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.128335e-01 0.505 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.128335e-01 0.505 0 0
Abacavir transmembrane transport R-HSA-2161517 3.443243e-01 0.463 0 0
Phase 2 - plateau phase R-HSA-5576893 2.585719e-01 0.587 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.911140e-01 0.719 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.769773e-01 0.558 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.769773e-01 0.558 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.443024e-01 0.463 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.490788e-01 0.604 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.022797e-01 0.520 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.739627e-01 0.427 0 0
Neuronal System R-HSA-112316 2.846902e-01 0.546 0 0
G1/S Transition R-HSA-69206 2.153280e-01 0.667 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.128335e-01 0.505 0 0
Signaling by ERBB4 R-HSA-1236394 1.906388e-01 0.720 0 0
FLT3 signaling in disease R-HSA-9682385 3.276826e-01 0.485 0 0
Histamine receptors R-HSA-390650 2.090059e-01 0.680 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.241396e-01 0.649 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.769773e-01 0.558 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.769773e-01 0.558 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.403852e-01 0.468 0 0
PLC beta mediated events R-HSA-112043 2.253720e-01 0.647 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.585719e-01 0.587 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.930641e-01 0.533 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.338503e-01 0.631 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.797229e-01 0.553 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.797229e-01 0.553 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.090059e-01 0.680 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.798322e-01 0.553 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.443243e-01 0.463 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.743739e-01 0.427 0 0
Regulation of PTEN localization R-HSA-8948747 3.743739e-01 0.427 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.095051e-01 0.679 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.611336e-01 0.442 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.134057e-01 0.504 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.029796e-01 0.693 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.095051e-01 0.679 0 0
Regulation of insulin secretion R-HSA-422356 2.536996e-01 0.596 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.443024e-01 0.463 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.896083e-01 0.538 0 0
Integration of energy metabolism R-HSA-163685 2.932660e-01 0.533 0 0
G-protein mediated events R-HSA-112040 2.774457e-01 0.557 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.102411e-01 0.508 0 0
Diseases of DNA repair R-HSA-9675135 2.490788e-01 0.604 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.798322e-01 0.553 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.128335e-01 0.505 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.128335e-01 0.505 0 0
Nef and signal transduction R-HSA-164944 3.443243e-01 0.463 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.241396e-01 0.649 0 0
Synthesis of PG R-HSA-1483148 2.585719e-01 0.587 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.273299e-01 0.485 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.769773e-01 0.558 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.390283e-01 0.622 0 0
Signal transduction by L1 R-HSA-445144 3.273299e-01 0.485 0 0
Ion channel transport R-HSA-983712 2.745188e-01 0.561 0 0
Signaling by SCF-KIT R-HSA-1433557 2.192317e-01 0.659 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.896083e-01 0.538 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.276826e-01 0.485 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.938720e-01 0.712 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.901116e-01 0.721 0 0
Tie2 Signaling R-HSA-210993 2.930641e-01 0.533 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.657255e-01 0.437 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.930641e-01 0.533 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.694356e-01 0.570 0 0
Other interleukin signaling R-HSA-449836 3.102411e-01 0.508 0 0
Triglyceride catabolism R-HSA-163560 3.276826e-01 0.485 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.930641e-01 0.533 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.770374e-01 0.424 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.778007e-01 0.423 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.778007e-01 0.423 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.778007e-01 0.423 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.783382e-01 0.422 0 0
Attenuation phase R-HSA-3371568 3.783382e-01 0.422 0 0
Aggrephagy R-HSA-9646399 3.783382e-01 0.422 0 0
Interleukin-2 family signaling R-HSA-451927 3.783382e-01 0.422 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.783382e-01 0.422 0 0
Diseases of Immune System R-HSA-5260271 3.783382e-01 0.422 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.783382e-01 0.422 0 0
Triglyceride metabolism R-HSA-8979227 3.844655e-01 0.415 0 0
Maturation of spike protein R-HSA-9694548 3.908971e-01 0.408 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.908971e-01 0.408 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.921666e-01 0.407 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.942836e-01 0.404 0 0
Syndecan interactions R-HSA-3000170 3.942836e-01 0.404 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.949467e-01 0.403 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.958183e-01 0.403 0 0
G alpha (s) signalling events R-HSA-418555 4.004353e-01 0.397 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.004353e-01 0.397 0 0
Type I hemidesmosome assembly R-HSA-446107 4.030480e-01 0.395 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.030480e-01 0.395 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.030480e-01 0.395 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.030480e-01 0.395 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.030480e-01 0.395 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.030480e-01 0.395 0 0
Regulation by c-FLIP R-HSA-3371378 4.030480e-01 0.395 0 0
Co-stimulation by ICOS R-HSA-9927354 4.030480e-01 0.395 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.030480e-01 0.395 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.030480e-01 0.395 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.030480e-01 0.395 0 0
Dimerization of procaspase-8 R-HSA-69416 4.030480e-01 0.395 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.030480e-01 0.395 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.030480e-01 0.395 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.033912e-01 0.394 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.033912e-01 0.394 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.033912e-01 0.394 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.034927e-01 0.394 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.034927e-01 0.394 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.034927e-01 0.394 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.053995e-01 0.392 0 0
Aquaporin-mediated transport R-HSA-445717 4.053995e-01 0.392 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.060014e-01 0.391 0 0
Signaling by GPCR R-HSA-372790 4.065063e-01 0.391 1 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.105640e-01 0.387 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.105640e-01 0.387 0 0
MTOR signalling R-HSA-165159 4.158103e-01 0.381 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.252896e-01 0.371 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.261937e-01 0.370 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.261937e-01 0.370 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.266260e-01 0.370 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 4.266260e-01 0.370 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.266260e-01 0.370 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.266260e-01 0.370 0 0
G protein gated Potassium channels R-HSA-1296059 4.266260e-01 0.370 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.266260e-01 0.370 0 0
Long-term potentiation R-HSA-9620244 4.266260e-01 0.370 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.266260e-01 0.370 0 0
TBC/RABGAPs R-HSA-8854214 4.281447e-01 0.368 0 0
Interleukin-1 signaling R-HSA-9020702 4.281781e-01 0.368 0 0
CASP8 activity is inhibited R-HSA-5218900 4.304096e-01 0.366 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.304096e-01 0.366 0 0
Calcineurin activates NFAT R-HSA-2025928 4.304096e-01 0.366 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.304096e-01 0.366 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.304096e-01 0.366 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.304096e-01 0.366 0 0
Interleukin-1 processing R-HSA-448706 4.304096e-01 0.366 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.304096e-01 0.366 0 0
ARMS-mediated activation R-HSA-170984 4.304096e-01 0.366 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.304096e-01 0.366 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.304096e-01 0.366 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.304096e-01 0.366 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.304096e-01 0.366 0 0
mRNA Editing R-HSA-75072 4.304096e-01 0.366 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.304096e-01 0.366 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.304096e-01 0.366 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.316698e-01 0.365 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.316698e-01 0.365 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.403853e-01 0.356 0 0
DAP12 interactions R-HSA-2172127 4.403853e-01 0.356 0 0
Transmission across Chemical Synapses R-HSA-112315 4.422356e-01 0.354 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.424554e-01 0.354 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.424554e-01 0.354 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.424554e-01 0.354 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.506731e-01 0.346 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.525238e-01 0.344 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.525238e-01 0.344 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.541872e-01 0.343 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.541872e-01 0.343 0 0
Regulation of CDH11 function R-HSA-9762292 4.565187e-01 0.341 0 0
PI3K/AKT activation R-HSA-198203 4.565187e-01 0.341 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 4.565187e-01 0.341 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.565187e-01 0.341 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.565187e-01 0.341 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.565187e-01 0.341 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.565187e-01 0.341 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.565187e-01 0.341 0 0
Maturation of spike protein R-HSA-9683686 4.565187e-01 0.341 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.565187e-01 0.341 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 4.565187e-01 0.341 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.565187e-01 0.341 0 0
Signaling by Leptin R-HSA-2586552 4.565187e-01 0.341 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.580398e-01 0.339 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.580398e-01 0.339 0 0
Cristae formation R-HSA-8949613 4.580398e-01 0.339 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.671670e-01 0.331 0 0
Kidney development R-HSA-9830369 4.671670e-01 0.331 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.682948e-01 0.329 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.689193e-01 0.329 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 4.733685e-01 0.325 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.733685e-01 0.325 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.733685e-01 0.325 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.733685e-01 0.325 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.764629e-01 0.322 0 0
Transcription of the HIV genome R-HSA-167172 4.772499e-01 0.321 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.814324e-01 0.317 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.814324e-01 0.317 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.814324e-01 0.317 0 0
Signaling by APC mutants R-HSA-4839744 4.814324e-01 0.317 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.814324e-01 0.317 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.814324e-01 0.317 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.814324e-01 0.317 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.814324e-01 0.317 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.814324e-01 0.317 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 4.814324e-01 0.317 0 0
Bicarbonate transporters R-HSA-425381 4.814324e-01 0.317 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 4.814324e-01 0.317 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.814324e-01 0.317 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.814324e-01 0.317 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.814324e-01 0.317 0 0
Late endosomal microautophagy R-HSA-9615710 4.884321e-01 0.311 0 0
Signaling by Erythropoietin R-HSA-9006335 4.884321e-01 0.311 0 0
Platelet calcium homeostasis R-HSA-418360 4.884321e-01 0.311 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.884321e-01 0.311 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.884321e-01 0.311 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.929892e-01 0.307 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.949298e-01 0.305 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.971888e-01 0.303 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.999052e-01 0.301 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.009332e-01 0.300 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.032227e-01 0.298 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.032227e-01 0.298 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.052056e-01 0.297 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.052056e-01 0.297 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.052056e-01 0.297 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.052056e-01 0.297 0 0
Signaling by AXIN mutants R-HSA-4839735 5.052056e-01 0.297 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.052056e-01 0.297 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.052056e-01 0.297 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.052056e-01 0.297 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.052056e-01 0.297 0 0
Sodium/Calcium exchangers R-HSA-425561 5.052056e-01 0.297 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.052056e-01 0.297 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.088334e-01 0.293 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.088334e-01 0.293 0 0
TCR signaling R-HSA-202403 5.088334e-01 0.293 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.114246e-01 0.291 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.123555e-01 0.290 0 0
Signaling by NTRKs R-HSA-166520 5.169449e-01 0.287 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.177337e-01 0.286 0 0
HSF1-dependent transactivation R-HSA-3371571 5.228022e-01 0.282 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.278902e-01 0.277 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.278902e-01 0.277 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.278902e-01 0.277 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.278902e-01 0.277 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.278902e-01 0.277 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.278902e-01 0.277 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.278902e-01 0.277 0 0
MET activates RAS signaling R-HSA-8851805 5.278902e-01 0.277 0 0
Disorders of Nervous System Development R-HSA-9697154 5.278902e-01 0.277 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.278902e-01 0.277 0 0
Pervasive developmental disorders R-HSA-9005895 5.278902e-01 0.277 0 0
Potential therapeutics for SARS R-HSA-9679191 5.303644e-01 0.275 1 1
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.322464e-01 0.274 0 0
Adipogenesis R-HSA-9843745 5.347240e-01 0.272 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.458963e-01 0.263 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.458963e-01 0.263 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.458963e-01 0.263 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.458963e-01 0.263 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.495362e-01 0.260 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.495362e-01 0.260 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.495362e-01 0.260 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.495362e-01 0.260 0 0
Chylomicron remodeling R-HSA-8963901 5.495362e-01 0.260 0 0
Mtb iron assimilation by chelation R-HSA-1222449 5.495362e-01 0.260 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.495362e-01 0.260 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.495362e-01 0.260 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.495362e-01 0.260 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.495362e-01 0.260 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.547716e-01 0.256 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.551817e-01 0.256 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.560382e-01 0.255 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.595402e-01 0.252 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.701909e-01 0.244 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.701909e-01 0.244 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.701909e-01 0.244 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.701909e-01 0.244 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.701909e-01 0.244 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.701909e-01 0.244 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.701909e-01 0.244 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.701909e-01 0.244 0 0
Regulation of KIT signaling R-HSA-1433559 5.701909e-01 0.244 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.701909e-01 0.244 0 0
Ciprofloxacin ADME R-HSA-9793528 5.701909e-01 0.244 0 0
P2Y receptors R-HSA-417957 5.701909e-01 0.244 0 0
G alpha (q) signalling events R-HSA-416476 5.723812e-01 0.242 0 0
eNOS activation R-HSA-203615 5.728888e-01 0.242 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.728888e-01 0.242 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.728888e-01 0.242 0 0
Interleukin-10 signaling R-HSA-6783783 5.733247e-01 0.242 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.823794e-01 0.235 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.823794e-01 0.235 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.825393e-01 0.235 0 0
DCC mediated attractive signaling R-HSA-418885 5.898998e-01 0.229 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.898998e-01 0.229 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.898998e-01 0.229 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.898998e-01 0.229 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.898998e-01 0.229 0 0
Erythropoietin activates RAS R-HSA-9027284 5.898998e-01 0.229 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.898998e-01 0.229 0 0
Signaling by Activin R-HSA-1502540 5.898998e-01 0.229 0 0
p38MAPK events R-HSA-171007 5.898998e-01 0.229 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.898998e-01 0.229 0 0
p75NTR signals via NF-kB R-HSA-193639 5.898998e-01 0.229 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.898998e-01 0.229 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.898998e-01 0.229 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.898998e-01 0.229 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.898998e-01 0.229 0 0
PTEN Regulation R-HSA-6807070 5.968830e-01 0.224 0 0
HSF1 activation R-HSA-3371511 5.986948e-01 0.223 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.986948e-01 0.223 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.986948e-01 0.223 0 0
G1/S-Specific Transcription R-HSA-69205 5.986948e-01 0.223 0 0
Cellular response to heat stress R-HSA-3371556 6.065498e-01 0.217 0 0
Extension of Telomeres R-HSA-180786 6.082271e-01 0.216 0 0
Regulation of beta-cell development R-HSA-186712 6.082271e-01 0.216 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.087061e-01 0.216 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.087061e-01 0.216 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.087061e-01 0.216 0 0
Differentiation of T cells R-HSA-9945266 6.087061e-01 0.216 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.087061e-01 0.216 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.087061e-01 0.216 0 0
Activation of SMO R-HSA-5635838 6.087061e-01 0.216 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.087061e-01 0.216 0 0
Fructose catabolism R-HSA-70350 6.087061e-01 0.216 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.087061e-01 0.216 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.087061e-01 0.216 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.087061e-01 0.216 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.109175e-01 0.214 0 0
PI Metabolism R-HSA-1483255 6.109175e-01 0.214 0 0
Voltage gated Potassium channels R-HSA-1296072 6.111512e-01 0.214 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.111512e-01 0.214 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.181606e-01 0.209 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.181606e-01 0.209 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.181606e-01 0.209 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.181606e-01 0.209 0 0
GABA receptor activation R-HSA-977443 6.181606e-01 0.209 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.181606e-01 0.209 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.181606e-01 0.209 0 0
MHC class II antigen presentation R-HSA-2132295 6.206170e-01 0.207 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.216708e-01 0.206 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.233102e-01 0.205 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.233102e-01 0.205 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.261842e-01 0.203 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.266510e-01 0.203 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.266510e-01 0.203 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.266510e-01 0.203 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.266510e-01 0.203 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.266510e-01 0.203 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.266510e-01 0.203 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.266510e-01 0.203 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.266510e-01 0.203 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.266510e-01 0.203 0 0
Passive transport by Aquaporins R-HSA-432047 6.266510e-01 0.203 0 0
Disorders of Developmental Biology R-HSA-9675151 6.266510e-01 0.203 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.266510e-01 0.203 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.295105e-01 0.201 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.351729e-01 0.197 0 0
Hemostasis R-HSA-109582 6.378659e-01 0.195 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.437741e-01 0.191 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.437741e-01 0.191 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.437741e-01 0.191 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.437741e-01 0.191 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.437741e-01 0.191 0 0
Choline catabolism R-HSA-6798163 6.437741e-01 0.191 0 0
Neutrophil degranulation R-HSA-6798695 6.485410e-01 0.188 1 1
XBP1(S) activates chaperone genes R-HSA-381038 6.506445e-01 0.187 0 0
Toll-like Receptor Cascades R-HSA-168898 6.509819e-01 0.186 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.556116e-01 0.183 0 0
Ion transport by P-type ATPases R-HSA-936837 6.561632e-01 0.183 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.561632e-01 0.183 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.580165e-01 0.182 0 0
GAB1 signalosome R-HSA-180292 6.601128e-01 0.180 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.601128e-01 0.180 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.601128e-01 0.180 0 0
Apoptotic factor-mediated response R-HSA-111471 6.601128e-01 0.180 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.601128e-01 0.180 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.601128e-01 0.180 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.601128e-01 0.180 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.610464e-01 0.180 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.627322e-01 0.179 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.627322e-01 0.179 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.627322e-01 0.179 0 0
Cellular response to hypoxia R-HSA-1234174 6.652273e-01 0.177 0 0
Peptide chain elongation R-HSA-156902 6.664991e-01 0.176 0 0
Selective autophagy R-HSA-9663891 6.664991e-01 0.176 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.690019e-01 0.175 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.690019e-01 0.175 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.690019e-01 0.175 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.690019e-01 0.175 0 0
Intra-Golgi traffic R-HSA-6811438 6.690019e-01 0.175 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.690019e-01 0.175 0 0
Viral Infection Pathways R-HSA-9824446 6.752034e-01 0.171 1 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.757030e-01 0.170 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.757030e-01 0.170 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.757030e-01 0.170 0 0
The NLRP3 inflammasome R-HSA-844456 6.757030e-01 0.170 0 0
Activation of GABAB receptors R-HSA-991365 6.797000e-01 0.168 0 0
GABA B receptor activation R-HSA-977444 6.797000e-01 0.168 0 0
Metabolism of steroid hormones R-HSA-196071 6.828302e-01 0.166 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.832347e-01 0.165 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.843045e-01 0.165 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.893446e-01 0.162 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.902475e-01 0.161 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.905791e-01 0.161 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.905791e-01 0.161 0 0
Pregnenolone biosynthesis R-HSA-196108 6.905791e-01 0.161 0 0
Disease R-HSA-1643685 6.909458e-01 0.161 1 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 6.913695e-01 0.160 0 0
IRE1alpha activates chaperones R-HSA-381070 6.967086e-01 0.157 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.986796e-01 0.156 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.039468e-01 0.152 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.039468e-01 0.152 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.047736e-01 0.152 0 0
FGFR2 ligand binding and activation R-HSA-190241 7.047736e-01 0.152 0 0
G-protein activation R-HSA-202040 7.047736e-01 0.152 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.047736e-01 0.152 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.047736e-01 0.152 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.047736e-01 0.152 0 0
Basigin interactions R-HSA-210991 7.047736e-01 0.152 0 0
Autophagy R-HSA-9612973 7.069279e-01 0.151 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.101049e-01 0.149 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.101049e-01 0.149 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.101049e-01 0.149 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.101049e-01 0.149 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.110593e-01 0.148 0 0
Phospholipid metabolism R-HSA-1483257 7.151805e-01 0.146 0 0
Collagen formation R-HSA-1474290 7.180463e-01 0.144 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.183178e-01 0.144 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.183178e-01 0.144 0 0
Glutathione synthesis and recycling R-HSA-174403 7.183178e-01 0.144 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.183178e-01 0.144 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.183178e-01 0.144 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.196893e-01 0.143 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.196893e-01 0.143 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.196893e-01 0.143 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.196893e-01 0.143 0 0
HIV Infection R-HSA-162906 7.209922e-01 0.142 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.221596e-01 0.141 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.237932e-01 0.140 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.249079e-01 0.140 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.255140e-01 0.139 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.285765e-01 0.138 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.285765e-01 0.138 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.312414e-01 0.136 0 0
FGFR2 alternative splicing R-HSA-6803529 7.312414e-01 0.136 0 0
Notch-HLH transcription pathway R-HSA-350054 7.312414e-01 0.136 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.312414e-01 0.136 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 7.312414e-01 0.136 0 0
Fructose metabolism R-HSA-5652084 7.312414e-01 0.136 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.312414e-01 0.136 0 0
mTORC1-mediated signalling R-HSA-166208 7.312414e-01 0.136 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.312414e-01 0.136 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.312414e-01 0.136 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.312414e-01 0.136 0 0
Eukaryotic Translation Termination R-HSA-72764 7.316447e-01 0.136 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.382570e-01 0.132 0 0
Signaling by NOTCH4 R-HSA-9013694 7.389794e-01 0.131 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.389794e-01 0.131 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.435728e-01 0.129 0 0
Growth hormone receptor signaling R-HSA-982772 7.435728e-01 0.129 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.463206e-01 0.127 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.463206e-01 0.127 0 0
Degradation of CDH1 R-HSA-9766229 7.468504e-01 0.127 0 0
SARS-CoV Infections R-HSA-9679506 7.488907e-01 0.126 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.496775e-01 0.125 0 0
Macroautophagy R-HSA-1632852 7.496775e-01 0.125 0 0
Signaling by NOTCH1 R-HSA-1980143 7.534960e-01 0.123 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.553391e-01 0.122 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.553391e-01 0.122 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.553391e-01 0.122 0 0
Deadenylation of mRNA R-HSA-429947 7.553391e-01 0.122 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 7.553391e-01 0.122 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.553391e-01 0.122 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.553887e-01 0.122 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.601152e-01 0.119 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.601152e-01 0.119 0 0
Translation of Structural Proteins R-HSA-9694635 7.605073e-01 0.119 0 0
Cilium Assembly R-HSA-5617833 7.628819e-01 0.118 0 0
Hedgehog 'off' state R-HSA-5610787 7.634745e-01 0.117 0 0
The phototransduction cascade R-HSA-2514856 7.636771e-01 0.117 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.665662e-01 0.115 0 0
Alpha-oxidation of phytanate R-HSA-389599 7.665662e-01 0.115 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.665662e-01 0.115 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.665662e-01 0.115 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.665662e-01 0.115 0 0
Selenocysteine synthesis R-HSA-2408557 7.694748e-01 0.114 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.717208e-01 0.113 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.717208e-01 0.113 0 0
Host Interactions of HIV factors R-HSA-162909 7.741811e-01 0.111 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.772787e-01 0.109 0 0
Metalloprotease DUBs R-HSA-5689901 7.772787e-01 0.109 0 0
Abacavir ADME R-HSA-2161522 7.772787e-01 0.109 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.795247e-01 0.108 0 0
Viral mRNA Translation R-HSA-192823 7.811167e-01 0.107 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.846948e-01 0.105 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.867605e-01 0.104 0 0
Triglyceride biosynthesis R-HSA-75109 7.875003e-01 0.104 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.875003e-01 0.104 0 0
Synthesis of PE R-HSA-1483213 7.875003e-01 0.104 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.875003e-01 0.104 0 0
Signaling by BMP R-HSA-201451 7.875003e-01 0.104 0 0
Signaling by NOTCH3 R-HSA-9012852 7.944332e-01 0.100 0 0
Platelet degranulation R-HSA-114608 7.946751e-01 0.100 0 0
Inflammasomes R-HSA-622312 7.972534e-01 0.098 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.972534e-01 0.098 0 0
Nucleotide Excision Repair R-HSA-5696398 7.976993e-01 0.098 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.015481e-01 0.096 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.015481e-01 0.096 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.015481e-01 0.096 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.015481e-01 0.096 0 0
Thyroxine biosynthesis R-HSA-209968 8.065593e-01 0.093 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.065593e-01 0.093 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.065593e-01 0.093 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.065593e-01 0.093 0 0
mRNA Capping R-HSA-72086 8.065593e-01 0.093 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.065593e-01 0.093 0 0
Regulation of CDH1 Function R-HSA-9764561 8.084436e-01 0.092 0 0
Synthesis of PA R-HSA-1483166 8.084436e-01 0.092 0 0
Membrane Trafficking R-HSA-199991 8.111765e-01 0.091 0 0
Innate Immune System R-HSA-168249 8.129828e-01 0.090 1 0
Dual incision in TC-NER R-HSA-6782135 8.151248e-01 0.089 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.154387e-01 0.089 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.154387e-01 0.089 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.154387e-01 0.089 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.154387e-01 0.089 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.154387e-01 0.089 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.154387e-01 0.089 0 0
Activation of BH3-only proteins R-HSA-114452 8.154387e-01 0.089 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.162291e-01 0.088 0 0
Metabolism of RNA R-HSA-8953854 8.187273e-01 0.087 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.212849e-01 0.086 0 0
Metabolism of non-coding RNA R-HSA-194441 8.215969e-01 0.085 0 0
snRNP Assembly R-HSA-191859 8.215969e-01 0.085 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.220343e-01 0.085 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.239110e-01 0.084 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.239110e-01 0.084 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.239110e-01 0.084 0 0
Budding and maturation of HIV virion R-HSA-162588 8.239110e-01 0.084 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.239110e-01 0.084 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.239110e-01 0.084 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.239110e-01 0.084 0 0
Downstream signal transduction R-HSA-186763 8.239110e-01 0.084 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.278650e-01 0.082 0 0
HIV Life Cycle R-HSA-162587 8.283097e-01 0.082 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.339342e-01 0.079 0 0
Collagen degradation R-HSA-1442490 8.339342e-01 0.079 0 0
MAP kinase activation R-HSA-450294 8.339342e-01 0.079 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.371364e-01 0.077 0 0
ER-Phagosome pathway R-HSA-1236974 8.376508e-01 0.077 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.397082e-01 0.076 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.397082e-01 0.076 0 0
Nuclear RNA decay R-HSA-9930044 8.397082e-01 0.076 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.398094e-01 0.076 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.398094e-01 0.076 0 0
Signaling by PDGF R-HSA-186797 8.398094e-01 0.076 0 0
Neurotransmitter release cycle R-HSA-112310 8.425871e-01 0.074 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.470677e-01 0.072 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.470677e-01 0.072 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.470677e-01 0.072 0 0
Heme degradation R-HSA-189483 8.470677e-01 0.072 0 0
Signaling by Hedgehog R-HSA-5358351 8.513048e-01 0.070 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.518493e-01 0.070 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.540898e-01 0.068 0 0
Nuclear import of Rev protein R-HSA-180746 8.540898e-01 0.068 0 0
Signal amplification R-HSA-392518 8.540898e-01 0.068 0 0
Mitophagy R-HSA-5205647 8.540898e-01 0.068 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.540898e-01 0.068 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.540898e-01 0.068 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.540898e-01 0.068 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.541162e-01 0.068 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.566233e-01 0.067 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.607899e-01 0.065 0 0
Regulation of Apoptosis R-HSA-169911 8.607899e-01 0.065 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.607899e-01 0.065 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.607899e-01 0.065 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.607899e-01 0.065 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.607899e-01 0.065 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 8.607899e-01 0.065 0 0
Rab regulation of trafficking R-HSA-9007101 8.620905e-01 0.064 0 0
Mitochondrial protein degradation R-HSA-9837999 8.653616e-01 0.063 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.664504e-01 0.062 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.671827e-01 0.062 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.671827e-01 0.062 0 0
RNA Polymerase III Transcription R-HSA-74158 8.671827e-01 0.062 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.671827e-01 0.062 0 0
Glycosphingolipid transport R-HSA-9845576 8.671827e-01 0.062 0 0
GPVI-mediated activation cascade R-HSA-114604 8.671827e-01 0.062 0 0
RUNX2 regulates bone development R-HSA-8941326 8.671827e-01 0.062 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.712653e-01 0.060 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.732823e-01 0.059 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.732823e-01 0.059 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.732823e-01 0.059 0 0
Lysine catabolism R-HSA-71064 8.732823e-01 0.059 0 0
Collagen chain trimerization R-HSA-8948216 8.732823e-01 0.059 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.770966e-01 0.057 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.775900e-01 0.057 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.791021e-01 0.056 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.791021e-01 0.056 0 0
Interleukin-17 signaling R-HSA-448424 8.804193e-01 0.055 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.846550e-01 0.053 0 0
Pentose phosphate pathway R-HSA-71336 8.846550e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.846550e-01 0.053 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.846550e-01 0.053 0 0
RAS processing R-HSA-9648002 8.846550e-01 0.053 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.847674e-01 0.053 0 0
Metabolism of cofactors R-HSA-8978934 8.847674e-01 0.053 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.889687e-01 0.051 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.899531e-01 0.051 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.899531e-01 0.051 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.899531e-01 0.051 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.899531e-01 0.051 0 0
Glycogen metabolism R-HSA-8982491 8.899531e-01 0.051 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.930276e-01 0.049 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.950082e-01 0.048 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.950082e-01 0.048 0 0
Extracellular matrix organization R-HSA-1474244 8.966532e-01 0.047 0 0
Translation of Structural Proteins R-HSA-9683701 8.998314e-01 0.046 0 0
Heme biosynthesis R-HSA-189451 8.998314e-01 0.046 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.007348e-01 0.045 0 0
Influenza Infection R-HSA-168255 9.018750e-01 0.045 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.044333e-01 0.044 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.077583e-01 0.042 0 0
RSV-host interactions R-HSA-9833110 9.085589e-01 0.042 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.088240e-01 0.042 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.088240e-01 0.042 0 0
ABC transporter disorders R-HSA-5619084 9.113296e-01 0.040 0 0
Cholesterol biosynthesis R-HSA-191273 9.113296e-01 0.040 0 0
Integrin cell surface interactions R-HSA-216083 9.113296e-01 0.040 0 0
Surfactant metabolism R-HSA-5683826 9.130133e-01 0.040 0 0
Platelet homeostasis R-HSA-418346 9.143967e-01 0.039 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.170103e-01 0.038 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.170103e-01 0.038 0 0
Somitogenesis R-HSA-9824272 9.170103e-01 0.038 0 0
PKR-mediated signaling R-HSA-9833482 9.177940e-01 0.037 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.208239e-01 0.036 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.208239e-01 0.036 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.227673e-01 0.035 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.244625e-01 0.034 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.244625e-01 0.034 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.244625e-01 0.034 0 0
Synthesis of PC R-HSA-1483191 9.244625e-01 0.034 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.266652e-01 0.033 0 0
Intraflagellar transport R-HSA-5620924 9.279341e-01 0.032 0 0
NGF-stimulated transcription R-HSA-9031628 9.279341e-01 0.032 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.279341e-01 0.032 0 0
Gluconeogenesis R-HSA-70263 9.279341e-01 0.032 0 0
Metal ion SLC transporters R-HSA-425410 9.279341e-01 0.032 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.299512e-01 0.032 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.312463e-01 0.031 0 0
DNA Damage Bypass R-HSA-73893 9.312463e-01 0.031 0 0
Ribosome-associated quality control R-HSA-9948299 9.320644e-01 0.031 0 0
SLC transporter disorders R-HSA-5619102 9.340678e-01 0.030 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.341199e-01 0.030 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.346274e-01 0.029 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.374216e-01 0.028 0 0
Complex IV assembly R-HSA-9864848 9.374216e-01 0.028 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.374216e-01 0.028 0 0
G alpha (i) signalling events R-HSA-418594 9.381624e-01 0.028 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.402983e-01 0.027 0 0
Orc1 removal from chromatin R-HSA-68949 9.402983e-01 0.027 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.430429e-01 0.025 0 0
Mitochondrial biogenesis R-HSA-1592230 9.447594e-01 0.025 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.456615e-01 0.024 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.481599e-01 0.023 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.481599e-01 0.023 0 0
G alpha (z) signalling events R-HSA-418597 9.481599e-01 0.023 0 0
Paracetamol ADME R-HSA-9753281 9.481599e-01 0.023 0 0
rRNA processing R-HSA-72312 9.505156e-01 0.022 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.505435e-01 0.022 0 0
Digestion R-HSA-8935690 9.505435e-01 0.022 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.549874e-01 0.020 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.549874e-01 0.020 0 0
Peroxisomal protein import R-HSA-9033241 9.570575e-01 0.019 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.570575e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.570575e-01 0.019 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.570575e-01 0.019 0 0
Protein localization R-HSA-9609507 9.588702e-01 0.018 0 0
Glutathione conjugation R-HSA-156590 9.590325e-01 0.018 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.605766e-01 0.017 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.605766e-01 0.017 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.609168e-01 0.017 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.609465e-01 0.017 0 0
tRNA processing in the nucleus R-HSA-6784531 9.627145e-01 0.017 0 0
Mitochondrial protein import R-HSA-1268020 9.627145e-01 0.017 0 0
Heme signaling R-HSA-9707616 9.627145e-01 0.017 0 0
Digestion and absorption R-HSA-8963743 9.644297e-01 0.016 0 0
Cellular response to starvation R-HSA-9711097 9.649879e-01 0.015 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.660660e-01 0.015 0 0
ABC-family proteins mediated transport R-HSA-382556 9.663344e-01 0.015 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.668497e-01 0.015 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.676272e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.691166e-01 0.014 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.695014e-01 0.013 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.705376e-01 0.013 0 0
Nicotinate metabolism R-HSA-196807 9.705376e-01 0.013 0 0
Selenoamino acid metabolism R-HSA-2408522 9.712106e-01 0.013 0 0
Leishmania infection R-HSA-9658195 9.713726e-01 0.013 0 0
Parasitic Infection Pathways R-HSA-9824443 9.713726e-01 0.013 0 0
Infectious disease R-HSA-5663205 9.715686e-01 0.013 1 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.724011e-01 0.012 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.735821e-01 0.012 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.744206e-01 0.011 0 0
Synthesis of DNA R-HSA-69239 9.755195e-01 0.011 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.755978e-01 0.011 0 0
Hedgehog 'on' state R-HSA-5632684 9.755978e-01 0.011 0 0
Metabolism of porphyrins R-HSA-189445 9.755978e-01 0.011 0 0
ECM proteoglycans R-HSA-3000178 9.755978e-01 0.011 0 0
Retinoid metabolism and transport R-HSA-975634 9.755978e-01 0.011 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.767210e-01 0.010 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.767210e-01 0.010 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.793380e-01 0.009 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.793380e-01 0.009 0 0
Iron uptake and transport R-HSA-917937 9.797899e-01 0.009 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.797899e-01 0.009 0 0
Inositol phosphate metabolism R-HSA-1483249 9.799749e-01 0.009 0 0
Metabolism of steroids R-HSA-8957322 9.804753e-01 0.009 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.815843e-01 0.008 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.816080e-01 0.008 0 0
PCP/CE pathway R-HSA-4086400 9.824548e-01 0.008 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.829635e-01 0.007 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.832626e-01 0.007 0 0
Vesicle-mediated transport R-HSA-5653656 9.833934e-01 0.007 0 0
Visual phototransduction R-HSA-2187338 9.834976e-01 0.007 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.836401e-01 0.007 0 0
Interferon alpha/beta signaling R-HSA-909733 9.836401e-01 0.007 0 0
Signaling by MET R-HSA-6806834 9.840334e-01 0.007 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.847686e-01 0.007 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.847686e-01 0.007 0 0
Peptide hormone metabolism R-HSA-2980736 9.849160e-01 0.007 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.861393e-01 0.006 0 0
Peptide ligand-binding receptors R-HSA-375276 9.867037e-01 0.006 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.867777e-01 0.006 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.867777e-01 0.006 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.872499e-01 0.006 0 0
PPARA activates gene expression R-HSA-1989781 9.877139e-01 0.005 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.879678e-01 0.005 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.880692e-01 0.005 0 0
Neddylation R-HSA-8951664 9.881279e-01 0.005 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.885938e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.886634e-01 0.005 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.890509e-01 0.005 0 0
Downstream TCR signaling R-HSA-202424 9.904957e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.911088e-01 0.004 0 0
Protein folding R-HSA-391251 9.917501e-01 0.004 0 0
Circadian clock R-HSA-9909396 9.924883e-01 0.003 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.931692e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.940711e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.943445e-01 0.002 0 0
Parasite infection R-HSA-9664407 9.948304e-01 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.948304e-01 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 9.948304e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.963001e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.967911e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.969392e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.974663e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.977682e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.979155e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.979610e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.982641e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.984975e-01 0.001 0 0
tRNA processing R-HSA-72306 9.986593e-01 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.990160e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.992935e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.996200e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.996614e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997274e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.997387e-01 0.000 0 0
Interferon Signaling R-HSA-913531 9.998597e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.998738e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999001e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999080e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999157e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999266e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999308e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999677e-01 0.000 0 0
Translation R-HSA-72766 9.999742e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999850e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999869e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999925e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999926e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999952e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle Checkpoints R-HSA-69620 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.887379e-15 14.724 1 0
Cellular responses to stress R-HSA-2262752 4.551914e-15 14.342 0 0
Nervous system development R-HSA-9675108 8.437695e-15 14.074 1 0
Cellular response to heat stress R-HSA-3371556 2.853273e-14 13.545 0 0
Apoptotic execution phase R-HSA-75153 3.116840e-12 11.506 1 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.483169e-12 11.261 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.520140e-12 11.258 0 0
Metabolism of RNA R-HSA-8953854 1.351153e-11 10.869 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.361122e-11 10.627 0 0
HSF1-dependent transactivation R-HSA-3371571 3.031675e-11 10.518 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.221678e-11 10.492 0 0
Mitotic Anaphase R-HSA-68882 5.119660e-11 10.291 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.526579e-11 10.258 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.809353e-11 10.236 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.170642e-11 10.210 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.823042e-11 10.008 0 0
Signaling by ALK in cancer R-HSA-9700206 9.823042e-11 10.008 0 0
Mitotic Prometaphase R-HSA-68877 1.123736e-10 9.949 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.504633e-10 9.823 0 0
G2/M Checkpoints R-HSA-69481 1.640845e-10 9.785 0 0
Attenuation phase R-HSA-3371568 2.312323e-10 9.636 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.685396e-10 9.571 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.853399e-10 9.545 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.881141e-10 9.540 1 1
Cellular Senescence R-HSA-2559583 3.352807e-10 9.475 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.850561e-10 9.314 0 0
Chromatin modifying enzymes R-HSA-3247509 5.357889e-10 9.271 0 0
Chromatin organization R-HSA-4839726 5.610943e-10 9.251 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.848357e-10 9.164 0 0
Signal Transduction R-HSA-162582 9.270911e-10 9.033 1 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.032190e-09 8.986 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.309830e-09 8.883 0 0
DNA methylation R-HSA-5334118 1.486349e-09 8.828 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.227027e-09 8.652 0 0
HDACs deacetylate histones R-HSA-3214815 2.358405e-09 8.627 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.587351e-09 8.587 0 0
Separation of Sister Chromatids R-HSA-2467813 2.811878e-09 8.551 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.332904e-09 8.477 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.864954e-09 8.104 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.864954e-09 8.104 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.951716e-09 8.100 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.467244e-09 8.072 0 0
Signaling by ROBO receptors R-HSA-376176 9.109448e-09 8.041 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.035365e-08 7.985 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.320284e-08 7.879 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.369314e-08 7.863 0 0
HSF1 activation R-HSA-3371511 1.452351e-08 7.838 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.452275e-08 7.838 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.891302e-08 7.723 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.484730e-08 7.605 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.579486e-08 7.588 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.777117e-08 7.556 0 0
Apoptosis R-HSA-109581 2.736110e-08 7.563 1 0
Meiotic recombination R-HSA-912446 2.872094e-08 7.542 0 0
Mitotic Prophase R-HSA-68875 2.975036e-08 7.527 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.298634e-08 7.482 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.308849e-08 7.480 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.308849e-08 7.480 0 0
Nucleosome assembly R-HSA-774815 4.676461e-08 7.330 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.676461e-08 7.330 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.522959e-08 7.345 0 0
mRNA Splicing R-HSA-72172 6.199721e-08 7.208 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.220709e-08 7.206 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.965430e-08 7.157 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.358553e-08 7.133 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.078049e-08 7.042 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.073187e-07 6.969 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.073187e-07 6.969 0 0
DNA Double Strand Break Response R-HSA-5693606 1.116738e-07 6.952 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.332116e-07 6.875 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.379712e-07 6.860 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.417793e-07 6.848 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.484284e-07 6.828 0 0
Peptide chain elongation R-HSA-156902 1.490531e-07 6.827 0 0
Programmed Cell Death R-HSA-5357801 1.556622e-07 6.808 1 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.884533e-07 6.725 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.268866e-07 6.644 0 0
Packaging Of Telomere Ends R-HSA-171306 2.796072e-07 6.553 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.824045e-07 6.549 0 0
Defective pyroptosis R-HSA-9710421 3.133222e-07 6.504 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.462398e-07 6.461 0 0
HATs acetylate histones R-HSA-3214847 3.895794e-07 6.409 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.099899e-07 6.387 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.199737e-07 6.377 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.199737e-07 6.377 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.320943e-07 6.364 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.677369e-07 6.330 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.448259e-07 6.352 0 0
mRNA 3'-end processing R-HSA-72187 4.797260e-07 6.319 0 0
L1CAM interactions R-HSA-373760 5.499821e-07 6.260 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.232525e-07 6.205 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.638203e-07 6.178 0 0
RNA Polymerase I Transcription R-HSA-73864 6.728838e-07 6.172 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.218273e-07 6.085 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.384905e-07 6.077 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.420256e-07 6.075 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.648185e-07 6.063 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.872075e-07 6.006 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.085504e-06 5.964 0 0
Diseases of programmed cell death R-HSA-9645723 1.133542e-06 5.946 0 0
Influenza Infection R-HSA-168255 1.170612e-06 5.932 0 0
Meiosis R-HSA-1500620 1.249615e-06 5.903 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.351060e-06 5.869 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.428798e-06 5.845 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.481360e-06 5.829 0 0
Kinesins R-HSA-983189 1.492221e-06 5.826 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.632051e-06 5.787 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.864737e-06 5.729 0 0
Homology Directed Repair R-HSA-5693538 1.936265e-06 5.713 0 0
Meiotic synapsis R-HSA-1221632 2.081272e-06 5.682 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.166648e-06 5.664 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.606353e-06 5.584 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.757131e-06 5.560 0 0
Eukaryotic Translation Termination R-HSA-72764 2.914415e-06 5.535 0 0
ESR-mediated signaling R-HSA-8939211 2.916030e-06 5.535 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.938845e-06 5.532 0 0
Recycling pathway of L1 R-HSA-437239 3.781807e-06 5.422 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.677786e-06 5.434 0 0
Cell-Cell communication R-HSA-1500931 3.853271e-06 5.414 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.008253e-06 5.397 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.193209e-06 5.377 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.514514e-06 5.345 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.743566e-06 5.241 0 0
Gene Silencing by RNA R-HSA-211000 5.832155e-06 5.234 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.082810e-06 5.216 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.225305e-06 5.206 0 0
Chromosome Maintenance R-HSA-73886 7.576342e-06 5.121 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.892565e-06 5.103 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.160228e-06 5.038 0 0
Depyrimidination R-HSA-73928 9.160228e-06 5.038 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.254358e-06 5.034 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.254358e-06 5.034 0 0
Membrane Trafficking R-HSA-199991 9.450819e-06 5.025 0 0
DNA Repair R-HSA-73894 1.046415e-05 4.980 0 0
RMTs methylate histone arginines R-HSA-3214858 1.620271e-05 4.790 0 0
Cleavage of the damaged purine R-HSA-110331 1.646165e-05 4.784 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.798204e-05 4.745 0 0
EPH-Ephrin signaling R-HSA-2682334 2.023285e-05 4.694 1 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.037889e-05 4.691 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.099925e-05 4.678 0 0
Selenocysteine synthesis R-HSA-2408557 2.184154e-05 4.661 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.198542e-05 4.658 0 0
Depurination R-HSA-73927 2.224160e-05 4.653 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.411154e-05 4.618 0 0
Amyloid fiber formation R-HSA-977225 2.488452e-05 4.604 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.654346e-05 4.576 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.053124e-05 4.515 0 0
Viral mRNA Translation R-HSA-192823 3.083555e-05 4.511 0 0
Cell junction organization R-HSA-446728 4.302611e-05 4.366 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.405436e-05 4.356 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.016756e-05 4.300 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.365580e-05 4.270 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.416624e-05 4.266 0 0
Signaling by WNT R-HSA-195721 5.691128e-05 4.245 0 0
Telomere Maintenance R-HSA-157579 5.838676e-05 4.234 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.194416e-05 4.208 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.534015e-05 4.185 0 0
Translation initiation complex formation R-HSA-72649 6.850869e-05 4.164 0 0
Signaling by Hippo R-HSA-2028269 6.875119e-05 4.163 0 0
Ribosome-associated quality control R-HSA-9948299 7.203702e-05 4.142 0 0
DNA Replication R-HSA-69306 7.423257e-05 4.129 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.168968e-05 4.088 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.168968e-05 4.088 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.168968e-05 4.088 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.131327e-05 4.090 0 0
Signaling by RAS mutants R-HSA-6802949 8.168968e-05 4.088 0 0
Muscle contraction R-HSA-397014 8.668501e-05 4.062 0 0
Reproduction R-HSA-1474165 8.733935e-05 4.059 0 0
Developmental Biology R-HSA-1266738 9.631122e-05 4.016 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.040859e-04 3.983 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.069648e-04 3.971 0 0
Autophagy R-HSA-9612973 1.083560e-04 3.965 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.086569e-04 3.964 0 0
Aggrephagy R-HSA-9646399 1.207394e-04 3.918 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.314245e-04 3.881 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.487434e-04 3.828 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.627833e-04 3.788 0 0
HCMV Early Events R-HSA-9609690 1.510630e-04 3.821 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.656670e-04 3.781 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.691996e-04 3.772 0 0
G2/M Transition R-HSA-69275 1.694043e-04 3.771 0 0
Semaphorin interactions R-HSA-373755 1.763864e-04 3.754 1 0
Metalloprotease DUBs R-HSA-5689901 1.775355e-04 3.751 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.841344e-04 3.735 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.990031e-04 3.701 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.093916e-04 3.679 0 0
Post NMDA receptor activation events R-HSA-438064 2.093916e-04 3.679 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.105493e-04 3.677 0 0
Macroautophagy R-HSA-1632852 2.114906e-04 3.675 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.282340e-04 3.642 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.594955e-04 3.586 0 0
Gene expression (Transcription) R-HSA-74160 2.636215e-04 3.579 0 0
Adherens junctions interactions R-HSA-418990 2.848617e-04 3.545 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.952531e-04 3.530 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.106115e-04 3.508 0 0
Interleukin-12 signaling R-HSA-9020591 3.319459e-04 3.479 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.554298e-04 3.449 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.089092e-04 3.388 0 0
rRNA processing R-HSA-72312 3.645355e-04 3.438 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.090303e-04 3.388 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.283059e-04 3.368 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.325535e-04 3.364 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.325535e-04 3.364 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.426592e-04 3.354 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.486178e-04 3.348 0 0
Cellular response to starvation R-HSA-9711097 4.877217e-04 3.312 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.977808e-04 3.303 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.977808e-04 3.303 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.229147e-04 3.282 0 0
Protein folding R-HSA-391251 5.330221e-04 3.273 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.450497e-04 3.264 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.870792e-04 3.231 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.360449e-04 3.197 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.734828e-04 3.112 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.006176e-04 3.097 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.821903e-04 3.008 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.640844e-04 3.016 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.049684e-03 2.979 1 1
Deubiquitination R-HSA-5688426 9.812024e-04 3.008 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.064315e-03 2.973 0 0
HCMV Infection R-HSA-9609646 1.055889e-03 2.976 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.073759e-03 2.969 0 0
Viral Infection Pathways R-HSA-9824446 1.026383e-03 2.989 1 0
Interleukin-12 family signaling R-HSA-447115 9.932474e-04 3.003 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.095985e-03 2.960 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.176442e-03 2.929 1 1
Signaling by AMER1 mutants R-HSA-4839748 1.235987e-03 2.908 0 0
Signaling by AXIN mutants R-HSA-4839735 1.235987e-03 2.908 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.235987e-03 2.908 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.286503e-03 2.891 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.347156e-03 2.871 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.409172e-03 2.851 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.418889e-03 2.848 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.476477e-03 2.831 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.485709e-03 2.828 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.488507e-03 2.827 0 0
Striated Muscle Contraction R-HSA-390522 1.508224e-03 2.822 0 0
Base Excision Repair R-HSA-73884 1.512897e-03 2.820 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.555806e-03 2.808 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.675411e-03 2.776 0 0
RNA Polymerase II Transcription R-HSA-73857 1.737796e-03 2.760 0 0
Cell-cell junction organization R-HSA-421270 1.835266e-03 2.736 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.842016e-03 2.735 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.842016e-03 2.735 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.842016e-03 2.735 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.842016e-03 2.735 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.842016e-03 2.735 0 0
RAF activation R-HSA-5673000 1.885323e-03 2.725 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.945728e-03 2.711 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.310313e-03 2.636 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.310313e-03 2.636 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.241743e-03 2.649 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.051721e-03 2.688 0 0
Smooth Muscle Contraction R-HSA-445355 2.299970e-03 2.638 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.322180e-03 2.634 0 0
Selective autophagy R-HSA-9663891 2.344857e-03 2.630 0 0
Ub-specific processing proteases R-HSA-5689880 2.419407e-03 2.616 0 0
HCMV Late Events R-HSA-9610379 2.480155e-03 2.606 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.693065e-03 2.570 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.722434e-03 2.565 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.793356e-03 2.554 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.875449e-03 2.541 0 0
PKR-mediated signaling R-HSA-9833482 2.887736e-03 2.539 0 0
MHC class II antigen presentation R-HSA-2132295 2.917204e-03 2.535 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.959018e-03 2.529 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.972590e-03 2.527 0 0
Regulation of TP53 Activity R-HSA-5633007 3.280454e-03 2.484 0 0
UCH proteinases R-HSA-5689603 3.427275e-03 2.465 0 0
Signaling by APC mutants R-HSA-4839744 3.476347e-03 2.459 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.476347e-03 2.459 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.476347e-03 2.459 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.476347e-03 2.459 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.476347e-03 2.459 0 0
Glycolysis R-HSA-70171 3.503338e-03 2.456 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.538340e-03 2.451 0 0
MAP2K and MAPK activation R-HSA-5674135 3.662314e-03 2.436 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.696649e-03 2.432 0 0
Late endosomal microautophagy R-HSA-9615710 3.713022e-03 2.430 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.740508e-03 2.427 0 0
Signaling by VEGF R-HSA-194138 3.987184e-03 2.399 1 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.156604e-03 2.381 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.156604e-03 2.381 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.581498e-03 2.339 0 0
Nuclear import of Rev protein R-HSA-180746 4.930151e-03 2.307 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.126056e-03 2.290 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.126056e-03 2.290 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.130396e-03 2.290 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.130396e-03 2.290 0 0
Metabolism of non-coding RNA R-HSA-194441 5.922384e-03 2.228 0 0
snRNP Assembly R-HSA-191859 5.922384e-03 2.228 0 0
Co-inhibition by PD-1 R-HSA-389948 5.298369e-03 2.276 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.974265e-03 2.224 0 0
Gap junction trafficking and regulation R-HSA-157858 6.156282e-03 2.211 0 0
Gap junction trafficking R-HSA-190828 6.185912e-03 2.209 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.241606e-03 2.205 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.435342e-03 2.191 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.507359e-03 2.187 0 0
ALK mutants bind TKIs R-HSA-9700645 6.614539e-03 2.180 0 0
Signaling by WNT in cancer R-HSA-4791275 6.938445e-03 2.159 0 0
SARS-CoV Infections R-HSA-9679506 6.964331e-03 2.157 1 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.985141e-03 2.156 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.985141e-03 2.156 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.985141e-03 2.156 0 0
HIV Life Cycle R-HSA-162587 7.024705e-03 2.153 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.137797e-03 2.146 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.382734e-03 2.132 0 0
Selenoamino acid metabolism R-HSA-2408522 7.689109e-03 2.114 0 0
Ion homeostasis R-HSA-5578775 8.133275e-03 2.090 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.262706e-03 2.083 1 1
Nephrin family interactions R-HSA-373753 8.262706e-03 2.083 0 0
Negative regulation of MET activity R-HSA-6807004 8.262706e-03 2.083 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.402853e-03 2.076 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.402853e-03 2.076 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.402853e-03 2.076 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.402853e-03 2.076 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.402853e-03 2.076 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.570386e-03 2.067 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.587614e-03 2.066 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.619393e-03 2.065 0 0
G alpha (12/13) signalling events R-HSA-416482 8.806530e-03 2.055 1 1
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.998961e-03 2.046 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.056428e-03 2.043 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.056428e-03 2.043 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.204850e-03 2.036 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.296483e-03 2.032 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.347069e-03 2.029 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.362400e-03 2.029 0 0
Josephin domain DUBs R-HSA-5689877 9.556191e-03 2.020 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.556191e-03 2.020 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.592776e-03 2.018 0 0
Neurexins and neuroligins R-HSA-6794361 9.685912e-03 2.014 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.790599e-03 2.009 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.931145e-03 2.003 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.009805e-02 1.996 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.135218e-02 1.945 1 0
Protein ubiquitination R-HSA-8852135 1.182182e-02 1.927 0 0
Centrosome maturation R-HSA-380287 1.182182e-02 1.927 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.184857e-02 1.926 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.204662e-02 1.919 0 0
Nucleotide Excision Repair R-HSA-5696398 1.210340e-02 1.917 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.219601e-02 1.914 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.252655e-02 1.902 0 0
Vesicle-mediated transport R-HSA-5653656 1.268082e-02 1.897 0 0
Regulation of PTEN localization R-HSA-8948747 1.272500e-02 1.895 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.276931e-02 1.894 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.332799e-02 1.875 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.487891e-02 1.827 0 0
Ephrin signaling R-HSA-3928664 1.487891e-02 1.827 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.306850e-02 1.884 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.385839e-02 1.858 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.422063e-02 1.847 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.422063e-02 1.847 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.584005e-02 1.800 0 0
mTORC1-mediated signalling R-HSA-166208 1.613156e-02 1.792 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.376878e-02 1.861 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.306850e-02 1.884 0 0
Budding and maturation of HIV virion R-HSA-162588 1.422063e-02 1.847 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.584005e-02 1.800 0 0
DAG and IP3 signaling R-HSA-1489509 1.592989e-02 1.798 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.410691e-02 1.851 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.409890e-02 1.851 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.409890e-02 1.851 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.304119e-02 1.885 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.630271e-02 1.788 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.643735e-02 1.784 0 0
Signaling by NOTCH R-HSA-157118 1.647646e-02 1.783 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.663914e-02 1.779 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.663914e-02 1.779 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.663914e-02 1.779 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.663914e-02 1.779 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.663914e-02 1.779 0 0
NRAGE signals death through JNK R-HSA-193648 1.669404e-02 1.777 0 0
Calmodulin induced events R-HSA-111933 1.679552e-02 1.775 0 0
CaM pathway R-HSA-111997 1.679552e-02 1.775 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.693427e-02 1.771 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.795032e-02 1.746 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.795032e-02 1.746 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.795032e-02 1.746 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.795032e-02 1.746 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.837998e-02 1.736 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.837998e-02 1.736 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.837998e-02 1.736 0 0
Regulation of signaling by CBL R-HSA-912631 1.863767e-02 1.730 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.863767e-02 1.730 0 0
Rap1 signalling R-HSA-392517 1.863767e-02 1.730 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.905898e-02 1.720 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.939802e-02 1.712 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.001666e-02 1.699 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.001666e-02 1.699 0 0
Hedgehog 'off' state R-HSA-5610787 2.048705e-02 1.689 0 0
Negative regulation of FLT3 R-HSA-9706369 2.127170e-02 1.672 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.198311e-02 1.658 0 0
Ca-dependent events R-HSA-111996 2.198311e-02 1.658 0 0
Cilium Assembly R-HSA-5617833 2.266826e-02 1.645 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.283243e-02 1.641 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.287972e-02 1.641 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.303024e-02 1.638 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.303024e-02 1.638 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.303024e-02 1.638 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.303024e-02 1.638 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.338209e-02 1.631 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.349436e-02 1.629 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.349436e-02 1.629 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.364053e-02 1.626 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.376576e-02 1.624 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.376576e-02 1.624 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.093754e-02 1.510 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.093754e-02 1.510 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.093754e-02 1.510 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.093754e-02 1.510 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.093754e-02 1.510 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.093754e-02 1.510 0 0
Gap junction degradation R-HSA-190873 2.548073e-02 1.594 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.060523e-02 1.514 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.673053e-02 1.573 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.673053e-02 1.573 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.810398e-02 1.551 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.810398e-02 1.551 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.386277e-02 1.622 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.173686e-02 1.498 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.159140e-02 1.500 0 0
Activation of the pre-replicative complex R-HSA-68962 2.813233e-02 1.551 0 0
Frs2-mediated activation R-HSA-170968 3.060523e-02 1.514 0 0
Generation of second messenger molecules R-HSA-202433 3.033433e-02 1.518 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.739297e-02 1.562 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.724468e-02 1.565 0 0
Long-term potentiation R-HSA-9620244 2.844913e-02 1.546 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.486617e-02 1.604 0 0
Adaptive Immune System R-HSA-1280218 2.961891e-02 1.528 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.143027e-02 1.503 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.486617e-02 1.604 0 0
MAP kinase activation R-HSA-450294 3.030578e-02 1.518 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.515189e-02 1.599 1 0
Unwinding of DNA R-HSA-176974 2.548073e-02 1.594 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.739297e-02 1.562 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.708381e-02 1.567 0 0
Glucose metabolism R-HSA-70326 2.496157e-02 1.603 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.173686e-02 1.498 0 0
Maturation of protein E R-HSA-9694493 2.486617e-02 1.604 0 0
Maturation of protein E R-HSA-9683683 2.486617e-02 1.604 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.233051e-02 1.490 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.246909e-02 1.489 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.246909e-02 1.489 0 0
EGFR downregulation R-HSA-182971 3.291850e-02 1.483 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.357310e-02 1.474 0 0
tRNA processing in the nucleus R-HSA-6784531 3.380214e-02 1.471 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.390177e-02 1.470 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.390177e-02 1.470 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.390177e-02 1.470 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.390177e-02 1.470 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.396373e-02 1.469 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.413116e-02 1.467 0 0
Death Receptor Signaling R-HSA-73887 3.454345e-02 1.462 0 0
FLT3 Signaling R-HSA-9607240 3.468652e-02 1.460 0 0
S Phase R-HSA-69242 3.499650e-02 1.456 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.589354e-02 1.445 0 0
Regulation of CDH1 Function R-HSA-9764561 3.632207e-02 1.440 0 0
RET signaling R-HSA-8853659 3.654884e-02 1.437 0 0
FLT3 signaling in disease R-HSA-9682385 3.654884e-02 1.437 0 0
Diseases of DNA repair R-HSA-9675135 3.707445e-02 1.431 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.792106e-02 1.421 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.861721e-02 1.413 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.861721e-02 1.413 0 0
Orc1 removal from chromatin R-HSA-68949 3.898584e-02 1.409 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.963193e-02 1.402 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.963193e-02 1.402 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.034322e-02 1.394 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.046121e-02 1.393 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.046121e-02 1.393 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.359872e-02 1.361 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.414351e-02 1.355 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.414351e-02 1.355 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.440298e-02 1.353 0 0
MTOR signalling R-HSA-165159 4.468674e-02 1.350 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.468674e-02 1.350 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.620717e-02 1.335 0 0
Co-stimulation by CD28 R-HSA-389356 4.689377e-02 1.329 0 0
HIV Infection R-HSA-162906 4.722529e-02 1.326 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.740295e-02 1.324 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.763765e-02 1.322 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.763765e-02 1.322 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.763765e-02 1.322 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.765885e-02 1.322 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.785067e-02 1.320 0 0
Translesion synthesis by REV1 R-HSA-110312 4.785067e-02 1.320 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.785067e-02 1.320 0 0
p75NTR signals via NF-kB R-HSA-193639 4.785067e-02 1.320 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.932901e-02 1.307 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.932901e-02 1.307 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.977262e-02 1.303 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.977262e-02 1.303 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.977262e-02 1.303 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.977262e-02 1.303 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.977262e-02 1.303 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.019581e-02 1.299 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.036754e-02 1.298 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.062679e-02 1.296 0 0
TCR signaling R-HSA-202403 5.070898e-02 1.295 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.104367e-02 1.292 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.125670e-02 1.290 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.174402e-02 1.286 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.174402e-02 1.286 0 0
Signaling by NOTCH3 R-HSA-9012852 5.394942e-02 1.268 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.598513e-02 1.252 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.598513e-02 1.252 0 0
Neurodegenerative Diseases R-HSA-8863678 5.598513e-02 1.252 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.633514e-02 1.249 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.633514e-02 1.249 0 0
Integration of provirus R-HSA-162592 5.633514e-02 1.249 0 0
NF-kB is activated and signals survival R-HSA-209560 5.633514e-02 1.249 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.771498e-02 1.239 0 0
Gap junction assembly R-HSA-190861 5.771498e-02 1.239 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.781887e-02 1.238 0 0
Protein hydroxylation R-HSA-9629569 5.781887e-02 1.238 0 0
Regulation of BACH1 activity R-HSA-9708530 5.833747e-02 1.234 0 0
Translesion synthesis by POLI R-HSA-5656121 5.833747e-02 1.234 0 0
Prolonged ERK activation events R-HSA-169893 5.833747e-02 1.234 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.970870e-02 1.224 0 0
TNF signaling R-HSA-75893 5.970870e-02 1.224 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.094181e-02 1.215 0 0
Interferon Signaling R-HSA-913531 6.096916e-02 1.215 0 0
Regulated Necrosis R-HSA-5218859 6.114761e-02 1.214 0 0
Signaling by FGFR in disease R-HSA-1226099 6.140652e-02 1.212 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.143188e-02 1.212 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.143908e-02 1.212 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.143908e-02 1.212 0 0
Activation of BH3-only proteins R-HSA-114452 6.143908e-02 1.212 0 0
Generic Transcription Pathway R-HSA-212436 6.267477e-02 1.203 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.279520e-02 1.202 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.374492e-02 1.196 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.172312e-02 1.144 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.172312e-02 1.144 0 0
Formation of annular gap junctions R-HSA-196025 6.516189e-02 1.186 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.516189e-02 1.186 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.516189e-02 1.186 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.517814e-02 1.070 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.517814e-02 1.070 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.009207e-02 1.154 0 0
Translesion synthesis by POLK R-HSA-5655862 7.009207e-02 1.154 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.933871e-02 1.101 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.933871e-02 1.101 0 0
HDMs demethylate histones R-HSA-3214842 6.499311e-02 1.187 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.499311e-02 1.187 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.484907e-02 1.126 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.555694e-02 1.068 1 1
Regulation of necroptotic cell death R-HSA-5675482 8.968790e-02 1.047 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.029066e-02 1.153 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.792369e-02 1.108 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.162688e-02 1.145 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.892711e-02 1.103 0 0
Neutrophil degranulation R-HSA-6798695 7.725258e-02 1.112 1 1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.273034e-02 1.082 0 0
DNA Damage Bypass R-HSA-73893 9.471091e-02 1.024 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.331792e-02 1.079 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.954242e-02 1.099 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.481092e-02 1.072 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.993459e-02 1.155 0 0
Trafficking of AMPA receptors R-HSA-399719 7.012712e-02 1.154 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.375836e-02 1.132 0 0
Opioid Signalling R-HSA-111885 7.428639e-02 1.129 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.012712e-02 1.154 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.828633e-02 1.166 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.505893e-02 1.070 0 0
PLC beta mediated events R-HSA-112043 9.465169e-02 1.024 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.471091e-02 1.024 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.471091e-02 1.024 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.311333e-02 1.136 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.391675e-02 1.131 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.119685e-02 1.090 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.827864e-02 1.166 0 0
Host Interactions of HIV factors R-HSA-162909 6.503855e-02 1.187 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.476245e-02 1.023 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.465169e-02 1.024 0 0
MAPK family signaling cascades R-HSA-5683057 6.856371e-02 1.164 0 0
Interleukin-17 signaling R-HSA-448424 7.290440e-02 1.137 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.516189e-02 1.186 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.516189e-02 1.186 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.968790e-02 1.047 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.029066e-02 1.153 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.221145e-02 1.085 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.555694e-02 1.068 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.993459e-02 1.155 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.968790e-02 1.047 0 0
Assembly Of The HIV Virion R-HSA-175474 7.933871e-02 1.101 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.828633e-02 1.166 0 0
Modulation by Mtb of host immune system R-HSA-9637628 6.516189e-02 1.186 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.490647e-02 1.023 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.711345e-02 1.013 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.711345e-02 1.013 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 9.723210e-02 1.012 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 9.723210e-02 1.012 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 9.723210e-02 1.012 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 9.723210e-02 1.012 0 0
Platelet sensitization by LDL R-HSA-432142 9.737760e-02 1.012 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.737760e-02 1.012 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.771291e-02 1.010 0 0
Signaling by MET R-HSA-6806834 9.926068e-02 1.003 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.019011e-01 0.992 0 0
Signaling by EGFR R-HSA-177929 1.035889e-01 0.985 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.035889e-01 0.985 0 0
G1 Phase R-HSA-69236 1.035983e-01 0.985 0 0
Cyclin D associated events in G1 R-HSA-69231 1.035983e-01 0.985 0 0
Netrin-1 signaling R-HSA-373752 1.035983e-01 0.985 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.036699e-01 0.984 0 0
2-LTR circle formation R-HSA-164843 1.036699e-01 0.984 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.036699e-01 0.984 0 0
Pexophagy R-HSA-9664873 1.036699e-01 0.984 0 0
DSCAM interactions R-HSA-376172 1.038885e-01 0.983 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.038885e-01 0.983 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.038885e-01 0.983 0 0
Signaling by Interleukins R-HSA-449147 1.048447e-01 0.979 0 0
Growth hormone receptor signaling R-HSA-982772 1.049144e-01 0.979 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.077133e-01 0.968 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.085107e-01 0.965 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.095082e-01 0.961 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.095082e-01 0.961 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.115697e-01 0.952 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.115697e-01 0.952 0 0
Mitophagy R-HSA-5205647 1.121551e-01 0.950 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.127320e-01 0.948 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.128549e-01 0.947 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.128549e-01 0.947 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.128549e-01 0.947 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.134666e-01 0.945 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.138372e-01 0.944 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.138372e-01 0.944 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.163296e-01 0.934 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.163296e-01 0.934 0 0
Signaling by NOTCH1 R-HSA-1980143 1.167128e-01 0.933 0 0
Deadenylation of mRNA R-HSA-429947 1.191815e-01 0.924 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.191815e-01 0.924 0 0
DCC mediated attractive signaling R-HSA-418885 1.203705e-01 0.919 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.206599e-01 0.918 0 0
Hemostasis R-HSA-109582 1.212912e-01 0.916 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.236965e-01 0.908 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.244568e-01 0.905 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.258331e-01 0.900 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.258331e-01 0.900 0 0
Nef and signal transduction R-HSA-164944 1.258331e-01 0.900 0 0
PECAM1 interactions R-HSA-210990 1.260487e-01 0.899 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.260487e-01 0.899 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.272148e-01 0.895 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.272148e-01 0.895 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.272148e-01 0.895 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.272148e-01 0.895 0 0
Formation of definitive endoderm R-HSA-9823730 1.294952e-01 0.888 0 0
Signal transduction by L1 R-HSA-445144 1.294952e-01 0.888 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.343563e-01 0.872 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.359725e-01 0.867 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.360070e-01 0.866 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.401484e-01 0.853 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.401484e-01 0.853 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.401484e-01 0.853 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.401484e-01 0.853 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.417656e-01 0.848 0 0
Synthesis of DNA R-HSA-69239 1.419578e-01 0.848 0 0
Signaling by ERBB2 R-HSA-1227986 1.428819e-01 0.845 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.428819e-01 0.845 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.428819e-01 0.845 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.428819e-01 0.845 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.428819e-01 0.845 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.428819e-01 0.845 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.472373e-01 0.832 0 0
Basigin interactions R-HSA-210991 1.472373e-01 0.832 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.489725e-01 0.827 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.489725e-01 0.827 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 1.489725e-01 0.827 0 0
MET interacts with TNS proteins R-HSA-8875513 1.489725e-01 0.827 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.489725e-01 0.827 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 1.489725e-01 0.827 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.489725e-01 0.827 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.489725e-01 0.827 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.494248e-01 0.826 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.497834e-01 0.825 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.500358e-01 0.824 0 0
Activation of RAC1 R-HSA-428540 1.502534e-01 0.823 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.502534e-01 0.823 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.502534e-01 0.823 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.502534e-01 0.823 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.502534e-01 0.823 0 0
G-protein mediated events R-HSA-112040 1.504026e-01 0.823 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.505083e-01 0.822 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.505083e-01 0.822 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.511100e-01 0.821 0 0
DNA strand elongation R-HSA-69190 1.515173e-01 0.820 0 0
G1/S Transition R-HSA-69206 1.527388e-01 0.816 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.528767e-01 0.816 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.539962e-01 0.812 0 0
Cardiac conduction R-HSA-5576891 1.558082e-01 0.807 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.570198e-01 0.804 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.570198e-01 0.804 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.570198e-01 0.804 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.570198e-01 0.804 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.570198e-01 0.804 0 0
G alpha (z) signalling events R-HSA-418597 1.571191e-01 0.804 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.571191e-01 0.804 0 0
Disorders of Developmental Biology R-HSA-9675151 1.612358e-01 0.793 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.612358e-01 0.793 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.612358e-01 0.793 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.612358e-01 0.793 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.612358e-01 0.793 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.651711e-01 0.782 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.654132e-01 0.781 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.660089e-01 0.780 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.382525e-01 0.623 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.382525e-01 0.623 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.382525e-01 0.623 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.382525e-01 0.623 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.382525e-01 0.623 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.382525e-01 0.623 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.382525e-01 0.623 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.382525e-01 0.623 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.382525e-01 0.623 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.970914e-01 0.705 0 0
HCN channels R-HSA-1296061 1.970914e-01 0.705 0 0
NADE modulates death signalling R-HSA-205025 1.970914e-01 0.705 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.970914e-01 0.705 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.970914e-01 0.705 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.970914e-01 0.705 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.970914e-01 0.705 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.467445e-01 0.608 0 0
IRS activation R-HSA-74713 2.467445e-01 0.608 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.467445e-01 0.608 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.467445e-01 0.608 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.467445e-01 0.608 0 0
Type I hemidesmosome assembly R-HSA-446107 1.902765e-01 0.721 0 0
Disorders of Nervous System Development R-HSA-9697154 1.760614e-01 0.754 0 0
Pervasive developmental disorders R-HSA-9005895 1.760614e-01 0.754 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.760614e-01 0.754 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.760614e-01 0.754 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.967632e-01 0.528 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.967632e-01 0.528 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.967632e-01 0.528 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.967632e-01 0.528 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.967632e-01 0.528 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.967632e-01 0.528 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.610147e-01 0.583 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.610147e-01 0.583 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.068226e-01 0.684 0 0
Notch-HLH transcription pathway R-HSA-350054 1.857289e-01 0.731 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.674767e-01 0.776 0 0
Cristae formation R-HSA-8949613 1.674767e-01 0.776 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.674767e-01 0.776 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.607224e-01 0.584 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.607224e-01 0.584 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.607224e-01 0.584 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.310423e-01 0.636 0 0
HIV elongation arrest and recovery R-HSA-167287 1.852424e-01 0.732 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.852424e-01 0.732 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.037436e-01 0.691 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.905559e-01 0.537 0 0
Phosphorylation of the APC/C R-HSA-176412 2.905559e-01 0.537 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.905559e-01 0.537 0 0
Dual Incision in GG-NER R-HSA-5696400 2.000823e-01 0.699 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.816023e-01 0.550 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.691961e-01 0.772 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.355205e-01 0.628 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.060873e-01 0.686 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.283905e-01 0.641 0 0
Dual incision in TC-NER R-HSA-6782135 1.946608e-01 0.711 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.213982e-01 0.655 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.213982e-01 0.655 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.145965e-01 0.668 0 0
Integrin signaling R-HSA-354192 2.837209e-01 0.547 0 0
GPER1 signaling R-HSA-9634597 2.371398e-01 0.625 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.170354e-01 0.499 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.169978e-01 0.499 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.316717e-01 0.479 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.912403e-01 0.718 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.984784e-01 0.525 0 0
Polo-like kinase mediated events R-HSA-156711 2.068226e-01 0.684 0 0
G-protein beta:gamma signalling R-HSA-397795 2.837209e-01 0.547 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.955152e-01 0.709 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.955152e-01 0.709 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.694199e-01 0.570 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.816023e-01 0.550 0 0
RNA Polymerase III Transcription R-HSA-74158 2.355205e-01 0.628 0 0
Translesion Synthesis by POLH R-HSA-110320 2.310423e-01 0.636 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.629763e-01 0.580 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.170354e-01 0.499 0 0
GPVI-mediated activation cascade R-HSA-114604 2.355205e-01 0.628 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.832328e-01 0.737 0 0
G-protein activation R-HSA-202040 2.816023e-01 0.550 0 0
Signaling by FGFR1 R-HSA-5654736 2.597014e-01 0.586 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.283666e-01 0.484 0 0
Developmental Cell Lineages R-HSA-9734767 2.531332e-01 0.597 0 0
Regulation of CDH11 function R-HSA-9762292 2.610147e-01 0.583 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.076459e-01 0.512 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.967632e-01 0.528 0 0
Platelet calcium homeostasis R-HSA-418360 2.037436e-01 0.691 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.986648e-01 0.525 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.722394e-01 0.565 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.803283e-01 0.744 0 0
Signaling by NOTCH4 R-HSA-9013694 3.283666e-01 0.484 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.832328e-01 0.737 0 0
Signaling by TGFB family members R-HSA-9006936 3.113391e-01 0.507 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.006146e-01 0.698 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.970914e-01 0.705 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.467445e-01 0.608 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.835060e-01 0.736 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.835060e-01 0.736 0 0
The NLRP3 inflammasome R-HSA-844456 2.310423e-01 0.636 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.670294e-01 0.777 0 0
Translation R-HSA-72766 2.060587e-01 0.686 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.000823e-01 0.699 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.066705e-01 0.685 0 0
Regulation of KIT signaling R-HSA-1433559 2.315375e-01 0.635 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.066705e-01 0.685 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.359871e-01 0.627 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.251001e-01 0.648 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.967632e-01 0.528 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.967632e-01 0.528 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.359871e-01 0.627 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.937554e-01 0.532 0 0
Signaling by NOTCH2 R-HSA-1980145 2.000823e-01 0.699 0 0
Signaling by FGFR2 R-HSA-5654738 3.153646e-01 0.501 0 0
Adrenoceptors R-HSA-390696 1.902765e-01 0.721 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.902765e-01 0.721 0 0
TBC/RABGAPs R-HSA-8854214 2.627917e-01 0.580 0 0
Inflammasomes R-HSA-622312 3.186790e-01 0.497 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.302607e-01 0.638 0 0
Signalling to ERKs R-HSA-187687 2.175290e-01 0.662 0 0
Signaling by FGFR4 R-HSA-5654743 2.627917e-01 0.580 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.251001e-01 0.648 0 0
Protein methylation R-HSA-8876725 2.607224e-01 0.584 0 0
Glycogen metabolism R-HSA-8982491 3.118106e-01 0.506 0 0
Cellular response to hypoxia R-HSA-1234174 2.952984e-01 0.530 0 0
Signaling by Hedgehog R-HSA-5358351 2.228595e-01 0.652 0 0
Glycogen synthesis R-HSA-3322077 2.560181e-01 0.592 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.675703e-01 0.776 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.522909e-01 0.598 0 0
Signaling by FGFR3 R-HSA-5654741 2.986648e-01 0.525 0 0
RUNX2 regulates bone development R-HSA-8941326 2.355205e-01 0.628 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.952785e-01 0.530 0 0
Neuronal System R-HSA-112316 3.055716e-01 0.515 0 0
Inhibition of PKR R-HSA-169131 2.382525e-01 0.623 0 0
MTF1 activates gene expression R-HSA-5660489 1.970914e-01 0.705 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.467445e-01 0.608 0 0
ARMS-mediated activation R-HSA-170984 2.251001e-01 0.648 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.967632e-01 0.528 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.068226e-01 0.684 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.000823e-01 0.699 0 0
Intraflagellar transport R-HSA-5620924 2.371398e-01 0.625 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.186790e-01 0.497 0 0
Platelet degranulation R-HSA-114608 2.282490e-01 0.642 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.977534e-01 0.526 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.037436e-01 0.691 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.722394e-01 0.565 0 0
Signaling by PTK6 R-HSA-8848021 1.769392e-01 0.752 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.769392e-01 0.752 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.955152e-01 0.709 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.902765e-01 0.721 0 0
Glycogen storage diseases R-HSA-3229121 1.835060e-01 0.736 0 0
Syndecan interactions R-HSA-3000170 2.063083e-01 0.685 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.105177e-01 0.508 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.760614e-01 0.754 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.760614e-01 0.754 0 0
Maturation of nucleoprotein R-HSA-9683610 2.032367e-01 0.692 0 0
Potential therapeutics for SARS R-HSA-9679191 2.812439e-01 0.551 1 1
Signaling by NTRKs R-HSA-166520 3.323176e-01 0.478 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.816023e-01 0.550 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.316717e-01 0.479 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.032367e-01 0.692 0 0
Maturation of nucleoprotein R-HSA-9694631 2.310423e-01 0.636 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.434782e-01 0.614 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.816023e-01 0.550 0 0
Specification of primordial germ cells R-HSA-9827857 1.835060e-01 0.736 0 0
NrCAM interactions R-HSA-447038 2.467445e-01 0.608 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.760614e-01 0.754 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.760614e-01 0.754 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.076487e-01 0.512 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.922058e-01 0.534 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.310423e-01 0.636 0 0
Pyroptosis R-HSA-5620971 1.852424e-01 0.732 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.967632e-01 0.528 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.607224e-01 0.584 0 0
Interleukin-7 signaling R-HSA-1266695 2.496634e-01 0.603 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.293332e-01 0.640 0 0
IRE1alpha activates chaperones R-HSA-381070 2.216033e-01 0.654 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.005299e-01 0.522 0 0
Signaling by Leptin R-HSA-2586552 2.610147e-01 0.583 0 0
Sensory processing of sound R-HSA-9659379 2.129463e-01 0.672 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.251001e-01 0.648 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 1.857289e-01 0.731 0 0
FOXO-mediated transcription R-HSA-9614085 3.323495e-01 0.478 0 0
FGFR2 alternative splicing R-HSA-6803529 3.340147e-01 0.476 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.340147e-01 0.476 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.340147e-01 0.476 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.344041e-01 0.476 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.344041e-01 0.476 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.344041e-01 0.476 0 0
Sodium/Calcium exchangers R-HSA-425561 3.344041e-01 0.476 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.351693e-01 0.475 0 0
Mitochondrial transcription initiation R-HSA-163282 3.351693e-01 0.475 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.351693e-01 0.475 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.351693e-01 0.475 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.351693e-01 0.475 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.351693e-01 0.475 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.351693e-01 0.475 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.351693e-01 0.475 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.351693e-01 0.475 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.351693e-01 0.475 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.351693e-01 0.475 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.351693e-01 0.475 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.351693e-01 0.475 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.351693e-01 0.475 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.351693e-01 0.475 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.351693e-01 0.475 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.351693e-01 0.475 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.351693e-01 0.475 0 0
Inhibition of membrane repair R-HSA-9635644 3.351693e-01 0.475 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.351693e-01 0.475 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.385667e-01 0.470 0 0
DARPP-32 events R-HSA-180024 3.423408e-01 0.466 0 0
Platelet homeostasis R-HSA-418346 3.454997e-01 0.462 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.462514e-01 0.461 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.462514e-01 0.461 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.462514e-01 0.461 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.462514e-01 0.461 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.462514e-01 0.461 0 0
CREB phosphorylation R-HSA-199920 3.462514e-01 0.461 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.462514e-01 0.461 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.512784e-01 0.454 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.512784e-01 0.454 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.512784e-01 0.454 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.512784e-01 0.454 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.517297e-01 0.454 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.517297e-01 0.454 0 0
Translation of Structural Proteins R-HSA-9683701 3.517297e-01 0.454 0 0
Gluconeogenesis R-HSA-70263 3.544048e-01 0.451 0 0
Heme signaling R-HSA-9707616 3.575476e-01 0.447 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.581531e-01 0.446 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.605633e-01 0.443 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.605633e-01 0.443 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.661661e-01 0.436 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.661661e-01 0.436 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.661661e-01 0.436 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.661661e-01 0.436 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.661661e-01 0.436 0 0
Interleukin-37 signaling R-HSA-9008059 3.661661e-01 0.436 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.711325e-01 0.430 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.711325e-01 0.430 0 0
Repression of WNT target genes R-HSA-4641265 3.711325e-01 0.430 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.711325e-01 0.430 0 0
Polymerase switching R-HSA-69091 3.711325e-01 0.430 0 0
Leading Strand Synthesis R-HSA-69109 3.711325e-01 0.430 0 0
Regulation of IFNG signaling R-HSA-877312 3.711325e-01 0.430 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.711325e-01 0.430 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.711325e-01 0.430 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.711325e-01 0.430 0 0
PKA activation in glucagon signalling R-HSA-164378 3.817571e-01 0.418 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.817571e-01 0.418 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.817571e-01 0.418 0 0
Mismatch Repair R-HSA-5358508 3.817571e-01 0.418 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.817571e-01 0.418 0 0
PKA activation R-HSA-163615 3.817571e-01 0.418 0 0
Apoptotic factor-mediated response R-HSA-111471 3.817571e-01 0.418 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.817571e-01 0.418 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.817571e-01 0.418 0 0
Potassium Channels R-HSA-1296071 3.866432e-01 0.413 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.871639e-01 0.412 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.888355e-01 0.410 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.900609e-01 0.409 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.900609e-01 0.409 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.915596e-01 0.407 0 0
Signaling by SCF-KIT R-HSA-1433557 3.922044e-01 0.406 0 0
PI3K Cascade R-HSA-109704 3.922940e-01 0.406 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.945347e-01 0.404 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.945347e-01 0.404 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.945347e-01 0.404 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.945347e-01 0.404 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.945347e-01 0.404 0 0
SOS-mediated signalling R-HSA-112412 3.945347e-01 0.404 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.945347e-01 0.404 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.945347e-01 0.404 0 0
CHL1 interactions R-HSA-447041 3.945347e-01 0.404 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.945347e-01 0.404 0 0
Immune System R-HSA-168256 3.980070e-01 0.400 1 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.074619e-01 0.390 0 0
Formation of axial mesoderm R-HSA-9796292 4.074619e-01 0.390 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.074619e-01 0.390 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.074619e-01 0.390 0 0
Interleukin-6 signaling R-HSA-1059683 4.074619e-01 0.390 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.074619e-01 0.390 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.099598e-01 0.387 0 0
Specification of the neural plate border R-HSA-9834899 4.120679e-01 0.385 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.120679e-01 0.385 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.125082e-01 0.385 0 0
MET promotes cell motility R-HSA-8875878 4.134366e-01 0.384 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.134366e-01 0.384 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.136943e-01 0.383 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.136943e-01 0.383 0 0
G protein gated Potassium channels R-HSA-1296059 4.136943e-01 0.383 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.136943e-01 0.383 0 0
TGFBR3 expression R-HSA-9839394 4.136943e-01 0.383 0 0
Signaling by FGFR R-HSA-190236 4.145158e-01 0.382 0 0
Regulation of insulin secretion R-HSA-422356 4.145158e-01 0.382 0 0
Toll-like Receptor Cascades R-HSA-168898 4.191074e-01 0.378 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.197603e-01 0.377 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.197603e-01 0.377 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.197603e-01 0.377 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 4.197603e-01 0.377 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.197603e-01 0.377 0 0
Potassium transport channels R-HSA-1296067 4.197603e-01 0.377 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.197603e-01 0.377 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.197603e-01 0.377 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.197603e-01 0.377 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.197603e-01 0.377 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.197603e-01 0.377 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.197603e-01 0.377 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.197603e-01 0.377 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.197603e-01 0.377 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.197603e-01 0.377 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.197603e-01 0.377 0 0
Inositol phosphate metabolism R-HSA-1483249 4.235716e-01 0.373 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.303323e-01 0.366 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.327839e-01 0.364 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.327839e-01 0.364 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.327839e-01 0.364 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.330487e-01 0.363 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.352554e-01 0.361 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.352554e-01 0.361 0 0
Stabilization of p53 R-HSA-69541 4.352554e-01 0.361 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.377047e-01 0.359 0 0
Signaling by ERBB4 R-HSA-1236394 4.395224e-01 0.357 0 0
Myogenesis R-HSA-525793 4.400407e-01 0.357 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.400407e-01 0.357 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.400407e-01 0.357 0 0
RSK activation R-HSA-444257 4.411189e-01 0.355 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.411189e-01 0.355 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.411189e-01 0.355 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.420478e-01 0.355 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.420478e-01 0.355 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.420478e-01 0.355 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.420478e-01 0.355 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.420478e-01 0.355 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.431327e-01 0.353 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.431327e-01 0.353 0 0
HDL assembly R-HSA-8963896 4.431327e-01 0.353 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.431327e-01 0.353 0 0
Signal regulatory protein family interactions R-HSA-391160 4.431327e-01 0.353 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.443836e-01 0.352 0 0
Infectious disease R-HSA-5663205 4.533198e-01 0.344 1 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.564519e-01 0.341 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.569530e-01 0.340 0 0
HIV Transcription Elongation R-HSA-167169 4.569530e-01 0.340 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.569530e-01 0.340 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.569530e-01 0.340 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.569530e-01 0.340 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.612895e-01 0.336 0 0
PTEN Regulation R-HSA-6807070 4.619639e-01 0.335 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.637154e-01 0.334 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.637154e-01 0.334 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.660990e-01 0.332 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.660990e-01 0.332 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.660990e-01 0.332 0 0
Stimuli-sensing channels R-HSA-2672351 4.666056e-01 0.331 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.684773e-01 0.329 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.715522e-01 0.326 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.715522e-01 0.326 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.765270e-01 0.322 0 0
Erythropoietin activates RAS R-HSA-9027284 4.779282e-01 0.321 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.779282e-01 0.321 0 0
Formation of the anterior neural plate R-HSA-9823739 4.779282e-01 0.321 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.779282e-01 0.321 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.784701e-01 0.320 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.784701e-01 0.320 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.784701e-01 0.320 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.846159e-01 0.315 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.846159e-01 0.315 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.856010e-01 0.314 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.856548e-01 0.314 0 0
Lipophagy R-HSA-9613354 4.856548e-01 0.314 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.856548e-01 0.314 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.856548e-01 0.314 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.856548e-01 0.314 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.856548e-01 0.314 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.856548e-01 0.314 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.856548e-01 0.314 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.856548e-01 0.314 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.856548e-01 0.314 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.856548e-01 0.314 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.856548e-01 0.314 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.887482e-01 0.311 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.917747e-01 0.308 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.917747e-01 0.308 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.917747e-01 0.308 0 0
The NLRP1 inflammasome R-HSA-844455 4.935925e-01 0.307 0 0
Axonal growth stimulation R-HSA-209563 4.935925e-01 0.307 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.935925e-01 0.307 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.935925e-01 0.307 0 0
Invadopodia formation R-HSA-8941237 4.935925e-01 0.307 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.935925e-01 0.307 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.935925e-01 0.307 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.935925e-01 0.307 0 0
MET activates PTPN11 R-HSA-8865999 4.935925e-01 0.307 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.935925e-01 0.307 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.935925e-01 0.307 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.935925e-01 0.307 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.935925e-01 0.307 0 0
Histamine receptors R-HSA-390650 4.935925e-01 0.307 0 0
FasL/ CD95L signaling R-HSA-75157 4.935925e-01 0.307 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.004547e-01 0.301 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.030219e-01 0.298 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.076165e-01 0.294 0 0
Regulation of Apoptosis R-HSA-169911 5.076165e-01 0.294 0 0
Oncogene Induced Senescence R-HSA-2559585 5.076165e-01 0.294 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.116714e-01 0.291 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.116714e-01 0.291 0 0
Degradation of CDH1 R-HSA-9766229 5.126158e-01 0.290 0 0
Integration of energy metabolism R-HSA-163685 5.134705e-01 0.289 0 0
Rab regulation of trafficking R-HSA-9007101 5.151275e-01 0.288 0 0
Mitochondrial biogenesis R-HSA-1592230 5.151275e-01 0.288 0 0
Disease R-HSA-1643685 5.158949e-01 0.287 1 0
IGF1R signaling cascade R-HSA-2428924 5.165850e-01 0.287 0 0
Signaling by Erythropoietin R-HSA-9006335 5.169830e-01 0.287 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.169830e-01 0.287 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.169830e-01 0.287 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.169830e-01 0.287 0 0
Glucagon-type ligand receptors R-HSA-420092 5.169830e-01 0.287 0 0
IRS-mediated signalling R-HSA-112399 5.238519e-01 0.281 0 0
Binding and entry of HIV virion R-HSA-173107 5.279096e-01 0.277 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.279096e-01 0.277 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.279096e-01 0.277 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.279096e-01 0.277 0 0
PI3K/AKT activation R-HSA-198203 5.279096e-01 0.277 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.279096e-01 0.277 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.279096e-01 0.277 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.279096e-01 0.277 0 0
Signal attenuation R-HSA-74749 5.279096e-01 0.277 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.279096e-01 0.277 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.279096e-01 0.277 0 0
Formation of apoptosome R-HSA-111458 5.279096e-01 0.277 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.279096e-01 0.277 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.286466e-01 0.277 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.286466e-01 0.277 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.286466e-01 0.277 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.302298e-01 0.276 0 0
Adipogenesis R-HSA-9843745 5.302445e-01 0.276 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.320320e-01 0.274 0 0
Cellular response to chemical stress R-HSA-9711123 5.337870e-01 0.273 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.338639e-01 0.273 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.414059e-01 0.266 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.416492e-01 0.266 0 0
DAP12 signaling R-HSA-2424491 5.416492e-01 0.266 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.416492e-01 0.266 0 0
Ca2+ pathway R-HSA-4086398 5.429215e-01 0.265 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.442218e-01 0.264 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.442218e-01 0.264 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.442218e-01 0.264 0 0
Response to metal ions R-HSA-5660526 5.442218e-01 0.264 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.511523e-01 0.259 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.512136e-01 0.259 0 0
Degradation of AXIN R-HSA-4641257 5.524007e-01 0.258 0 0
Degradation of DVL R-HSA-4641258 5.524007e-01 0.258 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.560360e-01 0.255 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.560360e-01 0.255 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.580337e-01 0.253 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.580337e-01 0.253 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.580337e-01 0.253 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.580337e-01 0.253 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.580337e-01 0.253 0 0
Regulation of gap junction activity R-HSA-191650 5.580337e-01 0.253 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.580337e-01 0.253 0 0
Dopamine receptors R-HSA-390651 5.580337e-01 0.253 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.580337e-01 0.253 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.580337e-01 0.253 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.580337e-01 0.253 0 0
Interleukin-38 signaling R-HSA-9007892 5.580337e-01 0.253 0 0
Interleukin-1 signaling R-HSA-9020702 5.590455e-01 0.253 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.657082e-01 0.247 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.659624e-01 0.247 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.677428e-01 0.246 0 0
Bicarbonate transporters R-HSA-425381 5.677428e-01 0.246 0 0
Interleukin-2 signaling R-HSA-9020558 5.677428e-01 0.246 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.677428e-01 0.246 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.754720e-01 0.240 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.754720e-01 0.240 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.754720e-01 0.240 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.815581e-01 0.235 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.817134e-01 0.235 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.825475e-01 0.235 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.825475e-01 0.235 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.825475e-01 0.235 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.825475e-01 0.235 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.891044e-01 0.230 0 0
G0 and Early G1 R-HSA-1538133 5.891044e-01 0.230 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.906638e-01 0.229 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.937251e-01 0.226 0 0
Signaling by ALK R-HSA-201556 5.952258e-01 0.225 0 0
RAS processing R-HSA-9648002 5.952258e-01 0.225 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.960794e-01 0.225 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.009777e-01 0.221 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.009777e-01 0.221 0 0
Signaling by TGFBR3 R-HSA-9839373 6.009777e-01 0.221 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.012609e-01 0.221 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.050864e-01 0.218 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.050864e-01 0.218 0 0
ERKs are inactivated R-HSA-202670 6.050864e-01 0.218 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.050864e-01 0.218 0 0
GAB1 signalosome R-HSA-180292 6.053441e-01 0.218 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.081206e-01 0.216 0 0
Nuclear RNA decay R-HSA-9930044 6.117912e-01 0.213 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.117912e-01 0.213 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.142780e-01 0.212 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.142780e-01 0.212 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.142780e-01 0.212 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.142780e-01 0.212 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.142780e-01 0.212 0 0
G2 Phase R-HSA-68911 6.142780e-01 0.212 0 0
Defective F9 activation R-HSA-9673221 6.142780e-01 0.212 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.142780e-01 0.212 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.142780e-01 0.212 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.142780e-01 0.212 0 0
PTK6 Down-Regulation R-HSA-8849472 6.142780e-01 0.212 0 0
Activation of AKT2 R-HSA-165158 6.142780e-01 0.212 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.142780e-01 0.212 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.142780e-01 0.212 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.142780e-01 0.212 0 0
Reelin signalling pathway R-HSA-8866376 6.142780e-01 0.212 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.142780e-01 0.212 0 0
Co-inhibition by BTLA R-HSA-9927353 6.142780e-01 0.212 0 0
Transmission across Chemical Synapses R-HSA-112315 6.177463e-01 0.209 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.199186e-01 0.208 0 0
PCP/CE pathway R-HSA-4086400 6.211974e-01 0.207 0 0
Interleukin-1 family signaling R-HSA-446652 6.217902e-01 0.206 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.281131e-01 0.202 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.300573e-01 0.201 0 0
TRP channels R-HSA-3295583 6.327087e-01 0.199 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.337307e-01 0.198 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.337856e-01 0.198 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.337856e-01 0.198 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.337856e-01 0.198 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 6.399289e-01 0.194 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 6.399289e-01 0.194 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.399289e-01 0.194 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.399289e-01 0.194 0 0
OAS antiviral response R-HSA-8983711 6.399289e-01 0.194 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.412324e-01 0.193 0 0
Insulin receptor signalling cascade R-HSA-74751 6.442708e-01 0.191 0 0
Ion transport by P-type ATPases R-HSA-936837 6.442708e-01 0.191 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.473918e-01 0.189 0 0
Signal amplification R-HSA-392518 6.548929e-01 0.184 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.548929e-01 0.184 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.548929e-01 0.184 0 0
Insulin processing R-HSA-264876 6.562784e-01 0.183 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.562784e-01 0.183 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.568541e-01 0.183 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.607670e-01 0.180 0 0
Plus-strand DNA synthesis R-HSA-164525 6.633675e-01 0.178 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.633675e-01 0.178 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.633675e-01 0.178 0 0
Cam-PDE 1 activation R-HSA-111957 6.633675e-01 0.178 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.633675e-01 0.178 0 0
Phosphorylation of Emi1 R-HSA-176417 6.633675e-01 0.178 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.633675e-01 0.178 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.633675e-01 0.178 0 0
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) R-HSA-5619063 6.633675e-01 0.178 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.633675e-01 0.178 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.633675e-01 0.178 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.633675e-01 0.178 0 0
Formation of the Editosome R-HSA-75094 6.633675e-01 0.178 0 0
Ceramide signalling R-HSA-193681 6.633675e-01 0.178 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.633675e-01 0.178 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.633675e-01 0.178 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.633675e-01 0.178 0 0
TRAIL signaling R-HSA-75158 6.633675e-01 0.178 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.633675e-01 0.178 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.698488e-01 0.174 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.723021e-01 0.172 0 0
Processing of SMDT1 R-HSA-8949664 6.723021e-01 0.172 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.723021e-01 0.172 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.723021e-01 0.172 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.723021e-01 0.172 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.723021e-01 0.172 0 0
Activation of GABAB receptors R-HSA-991365 6.738164e-01 0.171 0 0
GABA B receptor activation R-HSA-977444 6.738164e-01 0.171 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.752554e-01 0.171 0 0
PERK regulates gene expression R-HSA-381042 6.752554e-01 0.171 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.788073e-01 0.168 0 0
Lagging Strand Synthesis R-HSA-69186 6.862776e-01 0.164 0 0
ERK/MAPK targets R-HSA-198753 6.862776e-01 0.164 0 0
Extension of Telomeres R-HSA-180786 6.900302e-01 0.161 0 0
Regulation of beta-cell development R-HSA-186712 6.900302e-01 0.161 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.904407e-01 0.161 0 0
The phototransduction cascade R-HSA-2514856 6.904407e-01 0.161 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.948028e-01 0.158 0 0
Triglyceride catabolism R-HSA-163560 6.948028e-01 0.158 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.959010e-01 0.157 0 0
mRNA Capping R-HSA-72086 7.002837e-01 0.155 0 0
Removal of the Flap Intermediate R-HSA-69166 7.022701e-01 0.153 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.022701e-01 0.153 0 0
cGMP effects R-HSA-418457 7.022701e-01 0.153 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.022701e-01 0.153 0 0
Malate-aspartate shuttle R-HSA-9856872 7.022701e-01 0.153 0 0
Zinc transporters R-HSA-435354 7.022701e-01 0.153 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.022701e-01 0.153 0 0
Signaling by LTK in cancer R-HSA-9842640 7.062120e-01 0.151 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.062120e-01 0.151 0 0
STAT5 Activation R-HSA-9645135 7.062120e-01 0.151 0 0
Uncoating of the HIV Virion R-HSA-162585 7.062120e-01 0.151 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.062120e-01 0.151 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.062120e-01 0.151 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.062120e-01 0.151 0 0
Lactose synthesis R-HSA-5653890 7.062120e-01 0.151 0 0
Lipid particle organization R-HSA-8964572 7.062120e-01 0.151 0 0
VLDL assembly R-HSA-8866423 7.062120e-01 0.151 0 0
HDL clearance R-HSA-8964011 7.062120e-01 0.151 0 0
Neurofascin interactions R-HSA-447043 7.062120e-01 0.151 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.066806e-01 0.151 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.081925e-01 0.150 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.103234e-01 0.149 0 0
Ribavirin ADME R-HSA-9755088 7.103234e-01 0.149 0 0
Circadian clock R-HSA-9909396 7.143564e-01 0.146 0 0
Translation of Structural Proteins R-HSA-9694635 7.182237e-01 0.144 0 0
Aquaporin-mediated transport R-HSA-445717 7.201242e-01 0.143 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.258936e-01 0.139 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.258936e-01 0.139 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.299206e-01 0.137 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.299206e-01 0.137 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.299206e-01 0.137 0 0
Signaling by Activin R-HSA-1502540 7.299206e-01 0.137 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.299206e-01 0.137 0 0
p38MAPK events R-HSA-171007 7.299206e-01 0.137 0 0
Other semaphorin interactions R-HSA-416700 7.299206e-01 0.137 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.305658e-01 0.136 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.314220e-01 0.136 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.329236e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.329236e-01 0.135 0 0
Signaling by KIT in disease R-HSA-9669938 7.329236e-01 0.135 0 0
LDL clearance R-HSA-8964038 7.329236e-01 0.135 0 0
Mitochondrial protein import R-HSA-1268020 7.344169e-01 0.134 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.400770e-01 0.131 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.418920e-01 0.130 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.418920e-01 0.130 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.436057e-01 0.129 0 0
Netrin mediated repulsion signals R-HSA-418886 7.436057e-01 0.129 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.436057e-01 0.129 0 0
Disinhibition of SNARE formation R-HSA-114516 7.436057e-01 0.129 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.436057e-01 0.129 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.436057e-01 0.129 0 0
PTK6 Expression R-HSA-8849473 7.436057e-01 0.129 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.436057e-01 0.129 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.436057e-01 0.129 0 0
Opsins R-HSA-419771 7.436057e-01 0.129 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.436057e-01 0.129 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.436057e-01 0.129 0 0
LDL remodeling R-HSA-8964041 7.436057e-01 0.129 0 0
VLDL clearance R-HSA-8964046 7.436057e-01 0.129 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.436057e-01 0.129 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.436057e-01 0.129 0 0
Hedgehog 'on' state R-HSA-5632684 7.455924e-01 0.127 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.484924e-01 0.126 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.484924e-01 0.126 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.541088e-01 0.123 0 0
Formation of the ureteric bud R-HSA-9830674 7.541088e-01 0.123 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.541088e-01 0.123 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.553581e-01 0.122 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.553581e-01 0.122 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.553581e-01 0.122 0 0
Activation of the phototransduction cascade R-HSA-2485179 7.553581e-01 0.122 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.553581e-01 0.122 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.553581e-01 0.122 0 0
Ion channel transport R-HSA-983712 7.593905e-01 0.120 0 0
Interferon alpha/beta signaling R-HSA-909733 7.621491e-01 0.118 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.647438e-01 0.116 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.647438e-01 0.116 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.647438e-01 0.116 0 0
Interleukin-2 family signaling R-HSA-451927 7.647438e-01 0.116 0 0
Neddylation R-HSA-8951664 7.712325e-01 0.113 0 0
NGF-stimulated transcription R-HSA-9031628 7.718482e-01 0.112 0 0
Metal ion SLC transporters R-HSA-425410 7.718482e-01 0.112 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.739187e-01 0.111 0 0
Interleukin-6 family signaling R-HSA-6783589 7.739187e-01 0.111 0 0
Cardiogenesis R-HSA-9733709 7.757276e-01 0.110 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.757276e-01 0.110 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.762418e-01 0.110 0 0
Minus-strand DNA synthesis R-HSA-164516 7.762418e-01 0.110 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.762418e-01 0.110 0 0
Regulation by c-FLIP R-HSA-3371378 7.762418e-01 0.110 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.762418e-01 0.110 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.762418e-01 0.110 0 0
phospho-PLA2 pathway R-HSA-111995 7.762418e-01 0.110 0 0
Dimerization of procaspase-8 R-HSA-69416 7.762418e-01 0.110 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.762418e-01 0.110 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.762418e-01 0.110 0 0
MET receptor recycling R-HSA-8875656 7.762418e-01 0.110 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.762418e-01 0.110 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.762418e-01 0.110 0 0
Fructose biosynthesis R-HSA-5652227 7.762418e-01 0.110 0 0
Interleukin-9 signaling R-HSA-8985947 7.762418e-01 0.110 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.762418e-01 0.110 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.762418e-01 0.110 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.762418e-01 0.110 0 0
Alpha-defensins R-HSA-1462054 7.762418e-01 0.110 0 0
Sodium/Proton exchangers R-HSA-425986 7.762418e-01 0.110 0 0
Interleukin-23 signaling R-HSA-9020933 7.762418e-01 0.110 0 0
ER-Phagosome pathway R-HSA-1236974 7.767010e-01 0.110 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.786977e-01 0.109 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.786977e-01 0.109 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 7.786977e-01 0.109 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 7.786977e-01 0.109 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.801866e-01 0.108 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.858173e-01 0.105 0 0
Downstream TCR signaling R-HSA-202424 7.873123e-01 0.104 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.920482e-01 0.101 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.923996e-01 0.101 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.923996e-01 0.101 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.923996e-01 0.101 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.923996e-01 0.101 0 0
Laminin interactions R-HSA-3000157 7.923996e-01 0.101 0 0
Formation of the nephric duct R-HSA-9830364 7.923996e-01 0.101 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.948351e-01 0.100 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.948351e-01 0.100 0 0
Parasite infection R-HSA-9664407 7.966756e-01 0.099 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.966756e-01 0.099 0 0
Leishmania phagocytosis R-HSA-9664417 7.966756e-01 0.099 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.969500e-01 0.099 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.000614e-01 0.097 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.000614e-01 0.097 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.000614e-01 0.097 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.000614e-01 0.097 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.000614e-01 0.097 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.000614e-01 0.097 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.000614e-01 0.097 0 0
Parasitic Infection Pathways R-HSA-9824443 8.035182e-01 0.095 0 0
Leishmania infection R-HSA-9658195 8.035182e-01 0.095 0 0
Peroxisomal protein import R-HSA-9033241 8.041622e-01 0.095 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.047253e-01 0.094 0 0
CASP8 activity is inhibited R-HSA-5218900 8.047253e-01 0.094 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.047253e-01 0.094 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.047253e-01 0.094 0 0
Interleukin-21 signaling R-HSA-9020958 8.047253e-01 0.094 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.047253e-01 0.094 0 0
Calcineurin activates NFAT R-HSA-2025928 8.047253e-01 0.094 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.047253e-01 0.094 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.047253e-01 0.094 0 0
WNT mediated activation of DVL R-HSA-201688 8.047253e-01 0.094 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.047253e-01 0.094 0 0
mRNA Editing R-HSA-75072 8.047253e-01 0.094 0 0
Interleukin-1 processing R-HSA-448706 8.047253e-01 0.094 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.047253e-01 0.094 0 0
eNOS activation R-HSA-203615 8.074009e-01 0.093 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.074009e-01 0.093 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.096036e-01 0.092 0 0
Urea cycle R-HSA-70635 8.096036e-01 0.092 0 0
Gastrulation R-HSA-9758941 8.117098e-01 0.091 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.117858e-01 0.091 0 0
Signaling by Insulin receptor R-HSA-74752 8.169552e-01 0.088 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.195740e-01 0.086 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.195740e-01 0.086 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.195740e-01 0.086 0 0
Nephron development R-HSA-9831926 8.195740e-01 0.086 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.218167e-01 0.085 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.218200e-01 0.085 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.255865e-01 0.083 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.255865e-01 0.083 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.255865e-01 0.083 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.255865e-01 0.083 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.295844e-01 0.081 0 0
DNA replication initiation R-HSA-68952 8.295844e-01 0.081 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.295844e-01 0.081 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.295844e-01 0.081 0 0
Interleukin-27 signaling R-HSA-9020956 8.295844e-01 0.081 0 0
Sperm Motility And Taxes R-HSA-1300642 8.295844e-01 0.081 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.295844e-01 0.081 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.306483e-01 0.081 0 0
DAP12 interactions R-HSA-2172127 8.341980e-01 0.079 0 0
Amine ligand-binding receptors R-HSA-375280 8.341980e-01 0.079 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.347421e-01 0.078 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.352174e-01 0.078 0 0
G1/S-Specific Transcription R-HSA-69205 8.353289e-01 0.078 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.373603e-01 0.077 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.373603e-01 0.077 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.373603e-01 0.077 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.374815e-01 0.077 0 0
Protein localization R-HSA-9609507 8.400678e-01 0.076 0 0
Telomere Extension By Telomerase R-HSA-171319 8.404067e-01 0.076 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.458638e-01 0.073 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.465945e-01 0.072 0 0
tRNA processing R-HSA-72306 8.505399e-01 0.070 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.512802e-01 0.070 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.512802e-01 0.070 0 0
LGI-ADAM interactions R-HSA-5682910 8.512802e-01 0.070 0 0
vRNP Assembly R-HSA-192905 8.512802e-01 0.070 0 0
Chylomicron assembly R-HSA-8963888 8.512802e-01 0.070 0 0
Formation of the posterior neural plate R-HSA-9832991 8.512802e-01 0.070 0 0
Synthesis of PI R-HSA-1483226 8.512802e-01 0.070 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.512802e-01 0.070 0 0
Suppression of apoptosis R-HSA-9635465 8.512802e-01 0.070 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.512802e-01 0.070 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.512802e-01 0.070 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.530968e-01 0.069 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.535436e-01 0.069 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.535436e-01 0.069 0 0
Signaling by NODAL R-HSA-1181150 8.535436e-01 0.069 0 0
Creatine metabolism R-HSA-71288 8.535436e-01 0.069 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.597863e-01 0.066 0 0
RSV-host interactions R-HSA-9833110 8.627988e-01 0.064 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.682438e-01 0.061 0 0
Signalling to RAS R-HSA-167044 8.682438e-01 0.061 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.682438e-01 0.061 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.702149e-01 0.060 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.702149e-01 0.060 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.702149e-01 0.060 0 0
Plasmalogen biosynthesis R-HSA-75896 8.702149e-01 0.060 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.702149e-01 0.060 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.702149e-01 0.060 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.702149e-01 0.060 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.702149e-01 0.060 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.708062e-01 0.060 0 0
Diseases of Immune System R-HSA-5260271 8.810710e-01 0.055 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.810710e-01 0.055 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.815760e-01 0.055 0 0
Attachment and Entry R-HSA-9694614 8.815760e-01 0.055 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.815760e-01 0.055 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.815760e-01 0.055 0 0
Kidney development R-HSA-9830369 8.828109e-01 0.054 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.854767e-01 0.053 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.867399e-01 0.052 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.867399e-01 0.052 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.867399e-01 0.052 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.867399e-01 0.052 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.867399e-01 0.052 0 0
Interleukin-35 Signalling R-HSA-8984722 8.867399e-01 0.052 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.867399e-01 0.052 0 0
Signaling by LTK R-HSA-9842663 8.867399e-01 0.052 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.867399e-01 0.052 0 0
MET activates RAS signaling R-HSA-8851805 8.867399e-01 0.052 0 0
Interleukin-15 signaling R-HSA-8983432 8.867399e-01 0.052 0 0
Metallothioneins bind metals R-HSA-5661231 8.867399e-01 0.052 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.893190e-01 0.051 0 0
Transcription of the HIV genome R-HSA-167172 8.904812e-01 0.050 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.906193e-01 0.050 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.909270e-01 0.050 0 0
Triglyceride metabolism R-HSA-8979227 8.916758e-01 0.050 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.936503e-01 0.049 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.944131e-01 0.048 0 0
Azathioprine ADME R-HSA-9748787 8.944131e-01 0.048 0 0
GABA receptor activation R-HSA-977443 8.992749e-01 0.046 0 0
Intra-Golgi traffic R-HSA-6811438 8.994891e-01 0.046 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.011616e-01 0.045 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.011616e-01 0.045 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.011616e-01 0.045 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.011616e-01 0.045 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.011616e-01 0.045 0 0
Pyruvate metabolism R-HSA-70268 9.037144e-01 0.044 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.045707e-01 0.044 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.045707e-01 0.044 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.045707e-01 0.044 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.077181e-01 0.042 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.082756e-01 0.042 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.082756e-01 0.042 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.097730e-01 0.041 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.115057e-01 0.040 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.137477e-01 0.039 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.137477e-01 0.039 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.137477e-01 0.039 0 0
Biosynthesis of protectins R-HSA-9018681 9.137477e-01 0.039 0 0
Hydrolysis of LPC R-HSA-1483115 9.137477e-01 0.039 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.137477e-01 0.039 0 0
Physiological factors R-HSA-5578768 9.137477e-01 0.039 0 0
Prolactin receptor signaling R-HSA-1170546 9.137477e-01 0.039 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.137477e-01 0.039 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.137477e-01 0.039 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.137477e-01 0.039 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.144353e-01 0.039 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.144353e-01 0.039 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.144353e-01 0.039 0 0
Complex III assembly R-HSA-9865881 9.144353e-01 0.039 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.166257e-01 0.038 0 0
Hyaluronan metabolism R-HSA-2142845 9.166257e-01 0.038 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.166916e-01 0.038 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.233358e-01 0.035 0 0
Tight junction interactions R-HSA-420029 9.233358e-01 0.035 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.233358e-01 0.035 0 0
Hyaluronan degradation R-HSA-2160916 9.233358e-01 0.035 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.247317e-01 0.034 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.247317e-01 0.034 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.247317e-01 0.034 0 0
DNA Damage Reversal R-HSA-73942 9.247317e-01 0.034 0 0
Protein repair R-HSA-5676934 9.247317e-01 0.034 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.247317e-01 0.034 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.247317e-01 0.034 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.247317e-01 0.034 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.312793e-01 0.031 0 0
MET activates PTK2 signaling R-HSA-8874081 9.313577e-01 0.031 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.313577e-01 0.031 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.313577e-01 0.031 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.331452e-01 0.030 0 0
Iron uptake and transport R-HSA-917937 9.331452e-01 0.030 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.343175e-01 0.030 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.343175e-01 0.030 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.343175e-01 0.030 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.343175e-01 0.030 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.343175e-01 0.030 0 0
Killing mechanisms R-HSA-9664420 9.343175e-01 0.030 0 0
Activation of SMO R-HSA-5635838 9.343175e-01 0.030 0 0
Differentiation of T cells R-HSA-9945266 9.343175e-01 0.030 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.343175e-01 0.030 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.343175e-01 0.030 0 0
Voltage gated Potassium channels R-HSA-1296072 9.376808e-01 0.028 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.385805e-01 0.028 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.385805e-01 0.028 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.422838e-01 0.026 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.426830e-01 0.026 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.426830e-01 0.026 0 0
Fibronectin matrix formation R-HSA-1566977 9.426830e-01 0.026 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.426830e-01 0.026 0 0
Galactose catabolism R-HSA-70370 9.426830e-01 0.026 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.426830e-01 0.026 0 0
Coenzyme A biosynthesis R-HSA-196783 9.426830e-01 0.026 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.426830e-01 0.026 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.426830e-01 0.026 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.443581e-01 0.025 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.447082e-01 0.025 0 0
Insulin receptor recycling R-HSA-77387 9.450775e-01 0.025 0 0
ABC transporter disorders R-HSA-5619084 9.464235e-01 0.024 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.499835e-01 0.022 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.499835e-01 0.022 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.499835e-01 0.022 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.499835e-01 0.022 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.499835e-01 0.022 0 0
Choline catabolism R-HSA-6798163 9.499835e-01 0.022 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.509163e-01 0.022 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.509163e-01 0.022 0 0
COPII-mediated vesicle transport R-HSA-204005 9.532023e-01 0.021 0 0
RAB geranylgeranylation R-HSA-8873719 9.532961e-01 0.021 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.537207e-01 0.021 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.561593e-01 0.019 0 0
Neurotransmitter clearance R-HSA-112311 9.561593e-01 0.019 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.561593e-01 0.019 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.563544e-01 0.019 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.563544e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.563544e-01 0.019 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.601670e-01 0.018 0 0
Cargo concentration in the ER R-HSA-5694530 9.608634e-01 0.017 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.608634e-01 0.017 0 0
Downstream signal transduction R-HSA-186763 9.608634e-01 0.017 0 0
Other interleukin signaling R-HSA-449836 9.619142e-01 0.017 0 0
Diseases of hemostasis R-HSA-9671793 9.619142e-01 0.017 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.619142e-01 0.017 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.619142e-01 0.017 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.621730e-01 0.017 0 0
HIV Transcription Initiation R-HSA-167161 9.621730e-01 0.017 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.621730e-01 0.017 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.634000e-01 0.016 0 0
HS-GAG degradation R-HSA-2024096 9.650807e-01 0.015 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.655433e-01 0.015 0 0
Nucleotide biosynthesis R-HSA-8956320 9.656774e-01 0.015 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.658328e-01 0.015 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.667660e-01 0.015 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.667660e-01 0.015 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.667660e-01 0.015 0 0
Pregnenolone biosynthesis R-HSA-196108 9.667660e-01 0.015 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.688591e-01 0.014 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.690158e-01 0.014 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.691566e-01 0.014 0 0
PI Metabolism R-HSA-1483255 9.696576e-01 0.013 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.710000e-01 0.013 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.710000e-01 0.013 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.710000e-01 0.013 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.710000e-01 0.013 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.710000e-01 0.013 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.710000e-01 0.013 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.710000e-01 0.013 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.710000e-01 0.013 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.710000e-01 0.013 0 0
Mitochondrial protein degradation R-HSA-9837999 9.712717e-01 0.013 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.712848e-01 0.013 0 0
Surfactant metabolism R-HSA-5683826 9.721729e-01 0.012 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.722707e-01 0.012 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.746948e-01 0.011 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.746948e-01 0.011 0 0
Serine metabolism R-HSA-977347 9.746948e-01 0.011 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.749081e-01 0.011 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.752682e-01 0.011 0 0
RA biosynthesis pathway R-HSA-5365859 9.752682e-01 0.011 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.752682e-01 0.011 0 0
Innate Immune System R-HSA-168249 9.757598e-01 0.011 1 0
Integrin cell surface interactions R-HSA-216083 9.757745e-01 0.011 0 0
Dectin-2 family R-HSA-5621480 9.765048e-01 0.010 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.779191e-01 0.010 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.779191e-01 0.010 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.779191e-01 0.010 0 0
Cellular hexose transport R-HSA-189200 9.779191e-01 0.010 0 0
Fructose metabolism R-HSA-5652084 9.779191e-01 0.010 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.779191e-01 0.010 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.779743e-01 0.010 0 0
SLC transporter disorders R-HSA-5619102 9.798827e-01 0.009 0 0
HS-GAG biosynthesis R-HSA-2022928 9.803926e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.803926e-01 0.009 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.806674e-01 0.008 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.807327e-01 0.008 0 0
Interleukin-20 family signaling R-HSA-8854691 9.807327e-01 0.008 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.807327e-01 0.008 0 0
ECM proteoglycans R-HSA-3000178 9.823192e-01 0.008 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.824197e-01 0.008 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.824197e-01 0.008 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.831879e-01 0.007 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.831879e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.831879e-01 0.007 0 0
Peptide hormone metabolism R-HSA-2980736 9.834132e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.834975e-01 0.007 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.840560e-01 0.007 0 0
Elastic fibre formation R-HSA-1566948 9.844802e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.852718e-01 0.006 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.852850e-01 0.006 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.853304e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.853304e-01 0.006 0 0
Fertilization R-HSA-1187000 9.853304e-01 0.006 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.855471e-01 0.006 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.871999e-01 0.006 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.871999e-01 0.006 0 0
Sphingolipid catabolism R-HSA-9845614 9.871999e-01 0.006 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.871999e-01 0.006 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.880083e-01 0.005 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.888313e-01 0.005 0 0
Signaling by BMP R-HSA-201451 9.888313e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.888313e-01 0.005 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.888313e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.900257e-01 0.004 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.902548e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.903191e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.903191e-01 0.004 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.903191e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.912158e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.914970e-01 0.004 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.914970e-01 0.004 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.925809e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.927602e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.930147e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.930943e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.930943e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.932284e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.933277e-01 0.003 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.939926e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.939926e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.942277e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.943520e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.943520e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.943901e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.946734e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.949747e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.957004e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.957004e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.958124e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.962487e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.962487e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.966429e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.967270e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.967270e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.967270e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.970877e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.971444e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.974154e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.974625e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.975086e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.975086e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.975086e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.976957e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.981036e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.982504e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.983455e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.983455e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.983455e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.984234e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.985339e-01 0.001 0 0
Maturation of spike protein R-HSA-9694548 9.985565e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.986002e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.986255e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.989053e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989053e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.989099e-01 0.000 0 0
Defensins R-HSA-1461973 9.990415e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.990833e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991445e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.991638e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.991638e-01 0.000 0 0
Methylation R-HSA-156581 9.991638e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.992202e-01 0.000 0 0
Signaling by PDGF R-HSA-186797 9.992440e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.992705e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.992705e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.992920e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.992944e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993320e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994098e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994141e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994150e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995352e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.995656e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996314e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.996411e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997069e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.997204e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997532e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.997652e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997710e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998306e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998376e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998505e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998598e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998903e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998975e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998975e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999060e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999103e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999313e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999386e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999594e-01 0.000 1 0
Metabolism of steroid hormones R-HSA-196071 9.999639e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999672e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999685e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999693e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999760e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999791e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999818e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999861e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999930e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999945e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999947e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999948e-01 0.000 1 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999982e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999983e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999986e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999994e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999995e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999995e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999996e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999997e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999998e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999998e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Phospholipid metabolism R-HSA-1483257 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways