BRAF

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
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Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
P04049 S357 Sugiyama RAF1 RAF DssyyWEIEASEVMLSTRIGsGsFGtVYKGKWHGDVAVKIL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P10398 S528 Sugiyama ARAF ARAF1 PKS PKS2 PYSHIGCRDQIIFMVGRGYLsPDLSKISSNCPKAMRRLLSD
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P15056 S147 iPTMNet BRAF BRAF1 RAFB1 SLSVLPSSLSVFQNPTDVARsNPKsPQKPIVRVFLPNKQRT
P15056 S151 iPTMNet BRAF BRAF1 RAFB1 LPSSLSVFQNPTDVARsNPKsPQKPIVRVFLPNKQRTVVPA
P15056 S419 iPTMNet BRAF BRAF1 RAFB1 sAtPPAsLPGSLTNVKALQKsPGPQRERKsssssEDRNRMK
P15056 S446 Sugiyama BRAF BRAF1 RAFB1 RKsssssEDRNRMKtLGRRDssDDWEIPDGQITVGQRIGsG
P15056 S465 SIGNOR|PSP|Sugiyama BRAF BRAF1 RAFB1 DssDDWEIPDGQITVGQRIGsGsFGtVYKGKWHGDVAVKML
P15056 S467 SIGNOR|PSP BRAF BRAF1 RAFB1 sDDWEIPDGQITVGQRIGsGsFGtVYKGKWHGDVAVKMLNV
P15056 S614 SIGNOR|EPSD|PSP BRAF BRAF1 RAFB1 DFGLAtVKsRWsGsHQFEQLsGSILWMAPEVIRMQDKNPYS
P15056 S675 Sugiyama BRAF BRAF1 RAFB1 PYSNINNRDQIIFMVGRGYLsPDLSKVRSNCPKAMKRLMAE
P15056 S750 iPTMNet BRAF BRAF1 RAFB1 EPSLNRAGFQTEDFSLYACAsPKtPIQAGGYGAFPVH____
P15056 T373 GPS6|iPTMNet|EPSD|PSP BRAF BRAF1 RAFB1 HRNQFGQRDRsssAPNVHINtIEPVNIDDLIRDQGFRGDGG
P19634 T653 EPSD|PSP SLC9A1 APNH1 NHE1 KILRNNLQKTRQRLRsyNRHtLVADPyEEAWNQMLLRRQKA
P33981 S281 EPSD|PSP TTK MPS1 MPS1L1 QTNKTKQSCPFGRVPVNLLNsPDCDVKtDDsVVPCFMKRQT
P33981 S436 EPSD|PSP TTK MPS1 MPS1L1 VNTEQKHTTFEQPVFSVSKQsPPISTSKWFDPKSICKtPss
P36507 S222 SIGNOR|EPSD|PSP MAP2K2 MEK2 MKK2 PRKMK2 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGT
P36507 S226 SIGNOR|EPSD|PSP MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P68104 S21 SIGNOR|EPSD|PSP EEF1A1 EEF1A EF1A LENG7 MGKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEK
P68104 T88 SIGNOR|EPSD|PSP EEF1A1 EEF1A EF1A LENG7 ERGITIDISLWKFEtsKyyVtIIDAPGHRDFIKNMITGTSQ
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q02750 S218 SIGNOR|EPSD|PSP MAP2K1 MEK1 PRKMK1 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGT
Q02750 S222 SIGNOR|EPSD|PSP MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q02750 S248 SIGNOR MAP2K1 MEK1 PRKMK1 SYMsPERLQGTHYSVQsDIWsMGLsLVEMAVGRYPIPPPDA
Q02750 S252 SIGNOR MAP2K1 MEK1 PRKMK1 PERLQGTHYSVQsDIWsMGLsLVEMAVGRYPIPPPDAKELE
Q05639 S21 SIGNOR|EPSD|PSP EEF1A2 EEF1AL STN MGKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEK
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q92934 S118 EPSD|PSP BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S134 EPSD|PSP BAD BBC6 BCL2L8 LRRMsDEFVDsFKKGLPRPKsAGtATQMRQSSSWTRVFQsW
Q92934 S75 EPSD|PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 EPSD|PSP BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q9H9S0 S68 PSP NANOG TETVsPLPSSMDLLIQDsPDsSTsPKGKQPtsAEKSVAKKE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.305453e-09 8.200 0 0
Cell Cycle, Mitotic R-HSA-69278 1.987519e-07 6.702 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.297901e-07 6.367 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.457342e-06 5.836 1 0
Apoptotic execution phase R-HSA-75153 2.818146e-06 5.550 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.223525e-05 4.374 0 0
Cellular response to heat stress R-HSA-3371556 1.127510e-04 3.948 0 0
Cell Cycle Checkpoints R-HSA-69620 2.128552e-04 3.672 0 0
Apoptosis R-HSA-109581 1.957844e-04 3.708 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.370000e-04 3.360 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.876639e-04 3.312 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.449015e-04 3.191 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.449015e-04 3.191 0 0
Programmed Cell Death R-HSA-5357801 6.192854e-04 3.208 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.877655e-04 3.163 0 0
Signaling by Hippo R-HSA-2028269 7.210527e-04 3.142 0 0
Nervous system development R-HSA-9675108 7.420341e-04 3.130 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.581732e-04 3.120 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.880636e-04 3.052 1 1
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.017759e-03 2.992 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.099420e-03 2.959 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.075221e-03 2.969 0 0
Axon guidance R-HSA-422475 1.138247e-03 2.944 0 0
S Phase R-HSA-69242 1.227442e-03 2.911 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.357489e-03 2.867 0 0
G2/M Checkpoints R-HSA-69481 1.529683e-03 2.815 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.817465e-03 2.741 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.072908e-03 2.683 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.940890e-03 2.712 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.777652e-03 2.750 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.072908e-03 2.683 0 0
M Phase R-HSA-68886 2.063577e-03 2.685 0 0
Signaling by ERBB2 R-HSA-1227986 1.783838e-03 2.749 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.012693e-03 2.696 0 0
RAB geranylgeranylation R-HSA-8873719 1.783838e-03 2.749 0 0
Signal Transduction R-HSA-162582 1.799691e-03 2.745 1 0
Interleukin-37 signaling R-HSA-9008059 1.867245e-03 2.729 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.419932e-03 2.616 0 0
Semaphorin interactions R-HSA-373755 2.426756e-03 2.615 0 0
G2/M Transition R-HSA-69275 2.313295e-03 2.636 0 0
Signaling by KIT in disease R-HSA-9669938 2.419932e-03 2.616 0 0
ALK mutants bind TKIs R-HSA-9700645 2.747116e-03 2.561 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.668024e-03 2.574 1 1
Signaling by FGFR1 in disease R-HSA-5655302 2.668024e-03 2.574 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.747116e-03 2.561 0 0
Unwinding of DNA R-HSA-176974 2.747116e-03 2.561 0 0
Host Interactions of HIV factors R-HSA-162909 2.947300e-03 2.531 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.197838e-03 2.495 0 0
Signaling by SCF-KIT R-HSA-1433557 3.388874e-03 2.470 0 0
Mitotic Prometaphase R-HSA-68877 3.351910e-03 2.475 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.327521e-03 2.478 0 0
Nuclear import of Rev protein R-HSA-180746 3.800828e-03 2.420 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.044401e-03 2.393 0 0
Signaling by RAS mutants R-HSA-6802949 4.742930e-03 2.324 1 0
Signaling downstream of RAS mutants R-HSA-9649948 4.742930e-03 2.324 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.742930e-03 2.324 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.742930e-03 2.324 1 1
Chaperone Mediated Autophagy R-HSA-9613829 5.161807e-03 2.287 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.133550e-03 2.290 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.199158e-03 2.284 0 0
Signaling by ALK in cancer R-HSA-9700206 5.199158e-03 2.284 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.799630e-03 2.237 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.799630e-03 2.237 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.799630e-03 2.237 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.799630e-03 2.237 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.161807e-03 2.287 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.799630e-03 2.237 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.974515e-03 2.303 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.004669e-03 2.222 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.987054e-03 2.223 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.004669e-03 2.222 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.219973e-03 2.206 0 0
TCR signaling R-HSA-202403 6.338291e-03 2.198 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.477576e-03 2.189 0 0
Signaling by FGFR in disease R-HSA-1226099 6.515538e-03 2.186 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.805963e-03 2.167 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.059526e-03 2.151 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.972214e-03 2.157 0 0
Separation of Sister Chromatids R-HSA-2467813 7.135130e-03 2.147 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.374652e-03 2.132 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.995974e-03 2.097 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.571068e-03 2.121 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.571068e-03 2.121 0 0
Activation of the pre-replicative complex R-HSA-68962 7.995974e-03 2.097 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.995974e-03 2.097 0 0
Generation of second messenger molecules R-HSA-202433 7.789887e-03 2.108 0 0
G1/S Transition R-HSA-69206 8.008257e-03 2.096 0 0
Signaling by VEGF R-HSA-194138 8.008257e-03 2.096 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.654812e-03 2.063 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.729154e-03 2.059 0 0
HIV Infection R-HSA-162906 8.384355e-03 2.077 0 0
Gene expression (Transcription) R-HSA-74160 8.294939e-03 2.081 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.744133e-03 2.058 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.360656e-03 2.029 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 9.360656e-03 2.029 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.884298e-03 2.005 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.065107e-03 2.043 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.065107e-03 2.043 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.489809e-03 2.023 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.728200e-03 2.012 0 0
Nef and signal transduction R-HSA-164944 9.360656e-03 2.029 0 0
DNA Repair R-HSA-73894 9.362795e-03 2.029 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.884298e-03 2.005 0 0
Downstream signal transduction R-HSA-186763 9.065107e-03 2.043 0 0
DNA strand elongation R-HSA-69190 1.023267e-02 1.990 0 0
G0 and Early G1 R-HSA-1538133 1.023267e-02 1.990 0 0
Mitotic Anaphase R-HSA-68882 1.024618e-02 1.989 0 0
Signaling by MET R-HSA-6806834 1.032494e-02 1.986 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.150319e-02 1.939 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.150319e-02 1.939 0 0
Nucleotide Excision Repair R-HSA-5696398 1.122552e-02 1.950 0 0
Rab regulation of trafficking R-HSA-9007101 1.098071e-02 1.959 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.068432e-02 1.971 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.115574e-02 1.953 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.070931e-02 1.970 0 0
Homology Directed Repair R-HSA-5693538 1.162705e-02 1.935 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.191200e-02 1.924 0 0
mRNA Splicing R-HSA-72172 1.201310e-02 1.920 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.240441e-02 1.906 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.579013e-02 1.802 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.579013e-02 1.802 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.579013e-02 1.802 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.579013e-02 1.802 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.579013e-02 1.802 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.579013e-02 1.802 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.597606e-02 1.797 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.563015e-02 1.806 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.563015e-02 1.806 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.335258e-02 1.874 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.597606e-02 1.797 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.437067e-02 1.843 0 0
RAF activation R-HSA-5673000 1.437067e-02 1.843 1 1
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.580673e-02 1.801 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.374388e-02 1.862 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.288109e-02 1.890 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.580673e-02 1.801 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.335258e-02 1.874 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.335258e-02 1.874 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.653209e-02 1.782 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.667826e-02 1.778 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.695363e-02 1.771 0 0
Calmodulin induced events R-HSA-111933 1.770125e-02 1.752 0 0
CaM pathway R-HSA-111997 1.770125e-02 1.752 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.773236e-02 1.751 0 0
Signaling by NOTCH4 R-HSA-9013694 1.773236e-02 1.751 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.850549e-02 1.733 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.861620e-02 1.730 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.152007e-02 1.667 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.152007e-02 1.667 0 0
Centrosome maturation R-HSA-380287 1.899487e-02 1.721 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.955006e-02 1.709 1 1
Vpr-mediated nuclear import of PICs R-HSA-180910 1.955006e-02 1.709 0 0
Membrane Trafficking R-HSA-199991 1.947580e-02 1.711 0 0
Signaling by NOTCH1 R-HSA-1980143 2.032130e-02 1.692 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.143632e-02 1.669 0 0
tRNA processing in the nucleus R-HSA-6784531 1.991398e-02 1.701 0 0
Interferon Signaling R-HSA-913531 1.957934e-02 1.708 0 0
Specification of primordial germ cells R-HSA-9827857 2.152007e-02 1.667 0 0
Signaling by PDGF R-HSA-186797 1.991398e-02 1.701 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.200221e-02 1.658 0 0
Neutrophil degranulation R-HSA-6798695 2.201853e-02 1.657 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.273521e-02 1.643 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.363280e-02 1.626 0 0
HSF1-dependent transactivation R-HSA-3371571 2.384555e-02 1.623 0 0
MET activates STAT3 R-HSA-8875791 2.392124e-02 1.621 0 0
MET interacts with TNS proteins R-HSA-8875513 2.392124e-02 1.621 0 0
MET activates PTPN11 R-HSA-8865999 2.392124e-02 1.621 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.458266e-02 1.609 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.458266e-02 1.609 0 0
Regulation of CDH11 function R-HSA-9762292 2.458266e-02 1.609 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.479272e-02 1.606 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.967122e-02 1.528 0 0
Aggrephagy R-HSA-9646399 2.587338e-02 1.587 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.825083e-02 1.549 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.676063e-02 1.573 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.967591e-02 1.528 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.958468e-02 1.529 1 0
Signaling by Interleukins R-HSA-449147 2.594560e-02 1.586 0 0
FLT3 Signaling R-HSA-9607240 2.825083e-02 1.549 0 0
EPH-Ephrin signaling R-HSA-2682334 2.555418e-02 1.593 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.587338e-02 1.587 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.825083e-02 1.549 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.676063e-02 1.573 0 0
RNA Polymerase II Transcription R-HSA-73857 2.991347e-02 1.524 0 0
MAP2K and MAPK activation R-HSA-5674135 3.076791e-02 1.512 1 1
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.219459e-02 1.492 0 0
Signal transduction by L1 R-HSA-445144 3.219459e-02 1.492 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.219459e-02 1.492 0 0
Protein hydroxylation R-HSA-9629569 3.219459e-02 1.492 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.340248e-02 1.476 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.340248e-02 1.476 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 3.340248e-02 1.476 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 3.340248e-02 1.476 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.340248e-02 1.476 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.340248e-02 1.476 0 0
Ca-dependent events R-HSA-111996 3.342718e-02 1.476 0 0
Interleukin-1 family signaling R-HSA-446652 3.471881e-02 1.459 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.527094e-02 1.453 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.633013e-02 1.440 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.633013e-02 1.440 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.409202e-02 1.356 0 0
G2 Phase R-HSA-68911 4.409202e-02 1.356 0 0
MET activates RAS signaling R-HSA-8851805 4.137470e-02 1.383 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.328909e-02 1.364 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.406747e-02 1.356 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.898095e-02 1.409 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.137470e-02 1.383 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.044891e-02 1.393 0 0
Post NMDA receptor activation events R-HSA-438064 4.177711e-02 1.379 0 0
Regulation of IFNG signaling R-HSA-877312 4.137470e-02 1.383 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.227978e-02 1.374 0 0
HIV Life Cycle R-HSA-162587 4.235594e-02 1.373 0 0
DAG and IP3 signaling R-HSA-1489509 4.227978e-02 1.374 0 0
snRNP Assembly R-HSA-191859 4.249780e-02 1.372 0 0
Metabolism of non-coding RNA R-HSA-194441 4.249780e-02 1.372 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.958837e-02 1.402 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.715624e-02 1.430 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.075772e-02 1.390 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.109372e-02 1.386 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.764385e-02 1.424 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.448709e-02 1.352 0 0
Notch-HLH transcription pathway R-HSA-350054 4.547776e-02 1.342 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.552824e-02 1.342 0 0
Defective F9 secretion R-HSA-9673218 4.621962e-02 1.335 0 0
Interferon alpha/beta signaling R-HSA-909733 4.638986e-02 1.334 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.649221e-02 1.333 0 0
Interleukin-6 signaling R-HSA-1059683 4.797263e-02 1.319 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.831285e-02 1.316 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.831285e-02 1.316 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.048965e-02 1.297 0 0
Oncogene Induced Senescence R-HSA-2559585 5.129420e-02 1.290 0 0
Signalling to ERKs R-HSA-187687 5.129420e-02 1.290 1 0
G alpha (12/13) signalling events R-HSA-416482 5.489184e-02 1.260 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.505243e-02 1.259 0 0
G1/S-Specific Transcription R-HSA-69205 5.559989e-02 1.255 0 0
HSF1 activation R-HSA-3371511 5.559989e-02 1.255 0 0
RET signaling R-HSA-8853659 5.559989e-02 1.255 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.579177e-02 1.253 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.579177e-02 1.253 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.585822e-02 1.253 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.585822e-02 1.253 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.585822e-02 1.253 0 0
Metabolism of RNA R-HSA-8953854 5.705866e-02 1.244 0 0
Mitotic Prophase R-HSA-68875 5.756478e-02 1.240 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.259977e-02 1.203 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.341010e-02 1.134 0 0
MET promotes cell motility R-HSA-8875878 6.481731e-02 1.188 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.972764e-02 1.157 0 0
mRNA 3'-end processing R-HSA-72187 6.822112e-02 1.166 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.254074e-02 1.139 0 0
Meiotic synapsis R-HSA-1221632 7.254074e-02 1.139 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.725578e-02 1.172 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.341010e-02 1.134 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.532510e-02 1.185 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.867776e-02 1.163 0 0
Synthesis of DNA R-HSA-69239 6.016209e-02 1.221 0 0
Orc1 removal from chromatin R-HSA-68949 6.822112e-02 1.166 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.210688e-02 1.142 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.138161e-02 1.212 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.560422e-02 1.183 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.341010e-02 1.134 0 0
Interleukin-7 signaling R-HSA-1266695 6.138161e-02 1.212 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.004293e-02 1.222 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.402185e-02 1.194 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.341010e-02 1.134 0 0
Cellular response to chemical stress R-HSA-9711123 6.059906e-02 1.218 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.725578e-02 1.172 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.999618e-02 1.222 0 0
HIV Transcription Elongation R-HSA-167169 7.483741e-02 1.126 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.483741e-02 1.126 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.483741e-02 1.126 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.483741e-02 1.126 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.483741e-02 1.126 0 0
Interleukin-2 family signaling R-HSA-451927 7.483741e-02 1.126 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.487670e-02 1.126 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.903126e-02 1.102 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.903126e-02 1.102 0 0
Inflammasomes R-HSA-622312 7.983961e-02 1.098 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.014487e-02 1.096 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 8.214120e-02 1.085 0 0
SOS-mediated signalling R-HSA-112412 8.214120e-02 1.085 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.214120e-02 1.085 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.214120e-02 1.085 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.030566e-02 1.044 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.030566e-02 1.044 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.030566e-02 1.044 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.030566e-02 1.044 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 9.030566e-02 1.044 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 9.030566e-02 1.044 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.030566e-02 1.044 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.030566e-02 1.044 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 9.030566e-02 1.044 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 9.030566e-02 1.044 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 9.030566e-02 1.044 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 9.030566e-02 1.044 0 0
MET receptor recycling R-HSA-8875656 9.644014e-02 1.016 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 1.113789e-01 0.953 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.653866e-02 1.063 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.560209e-02 1.068 0 0
DAP12 signaling R-HSA-2424491 9.350096e-02 1.029 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.113789e-01 0.953 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.653866e-02 1.063 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.081872e-01 0.966 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.348312e-02 1.029 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.350096e-02 1.029 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.653866e-02 1.063 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.350096e-02 1.029 0 0
Ephrin signaling R-HSA-3928664 9.712247e-02 1.013 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.787913e-02 1.056 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.026512e-01 0.989 1 0
Mismatch Repair R-HSA-5358508 9.712247e-02 1.013 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.113789e-01 0.953 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.787913e-02 1.056 0 0
IRS-mediated signalling R-HSA-112399 9.134255e-02 1.039 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.644014e-02 1.016 0 0
Activation of RAS in B cells R-HSA-1169092 9.644014e-02 1.016 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.113789e-01 0.953 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.113789e-01 0.953 0 0
Interleukin-9 signaling R-HSA-8985947 9.644014e-02 1.016 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.067408e-01 0.972 0 0
MAPK family signaling cascades R-HSA-5683057 1.094273e-01 0.961 1 0
The NLRP3 inflammasome R-HSA-844456 1.067408e-01 0.972 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.653866e-02 1.063 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.239058e-02 1.034 0 0
Activation of BH3-only proteins R-HSA-114452 9.350096e-02 1.029 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.113789e-01 0.953 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.113789e-01 0.953 0 0
Interleukin-21 signaling R-HSA-9020958 1.113789e-01 0.953 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.350096e-02 1.029 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.787913e-02 1.056 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.067408e-01 0.972 0 0
Signaling by Erythropoietin R-HSA-9006335 8.653866e-02 1.063 0 0
Signaling by EGFR R-HSA-177929 8.641547e-02 1.063 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.904185e-02 1.050 0 0
Cellular responses to stress R-HSA-2262752 8.699731e-02 1.060 0 0
Cellular responses to stimuli R-HSA-8953897 9.833253e-02 1.007 0 0
Generic Transcription Pathway R-HSA-212436 1.110902e-01 0.954 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.067408e-01 0.972 0 0
Adrenoceptors R-HSA-390696 9.644014e-02 1.016 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.033035e-01 0.986 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.081872e-01 0.966 0 0
Glycolysis R-HSA-70171 8.511918e-02 1.070 0 0
TBC/RABGAPs R-HSA-8854214 9.723024e-02 1.012 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.113789e-01 0.953 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.134255e-02 1.039 0 0
Influenza Infection R-HSA-168255 9.268226e-02 1.033 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.641547e-02 1.063 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 9.644014e-02 1.016 0 0
Tie2 Signaling R-HSA-210993 9.712247e-02 1.013 0 0
Regulation of beta-cell development R-HSA-186712 1.016420e-01 0.993 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.121075e-01 0.950 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.125234e-01 0.949 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.125234e-01 0.949 0 0
PLC beta mediated events R-HSA-112043 1.125234e-01 0.949 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.323565e-01 0.878 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.323565e-01 0.878 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 1.323565e-01 0.878 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.323565e-01 0.878 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.323565e-01 0.878 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.323565e-01 0.878 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 1.323565e-01 0.878 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.323565e-01 0.878 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.724659e-01 0.763 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.724659e-01 0.763 0 0
Defective factor IX causes thrombophilia R-HSA-9672383 1.724659e-01 0.763 0 0
Defective cofactor function of FVIIIa variant R-HSA-9672396 1.724659e-01 0.763 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.724659e-01 0.763 0 0
Defective F9 variant does not activate FX R-HSA-9673202 1.724659e-01 0.763 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.724659e-01 0.763 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.107235e-01 0.676 0 0
The IPAF inflammasome R-HSA-844623 2.107235e-01 0.676 0 0
Axonal growth stimulation R-HSA-209563 2.107235e-01 0.676 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 2.107235e-01 0.676 0 0
Signalling to STAT3 R-HSA-198745 2.107235e-01 0.676 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.107235e-01 0.676 0 0
Defective ABCC2 causes DJS R-HSA-5679001 2.107235e-01 0.676 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 2.107235e-01 0.676 0 0
Alternative complement activation R-HSA-173736 2.472147e-01 0.607 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.472147e-01 0.607 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.472147e-01 0.607 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.472147e-01 0.607 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.472147e-01 0.607 0 0
Defective MAT1A causes MATD R-HSA-5579024 2.472147e-01 0.607 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.820208e-01 0.550 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.820208e-01 0.550 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 2.820208e-01 0.550 0 0
Defective F9 activation R-HSA-9673221 2.820208e-01 0.550 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.591733e-01 0.798 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.758431e-01 0.755 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.758431e-01 0.755 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.152196e-01 0.501 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.152196e-01 0.501 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.152196e-01 0.501 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.152196e-01 0.501 0 0
Negative regulation of MET activity R-HSA-6807004 1.167132e-01 0.933 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.927698e-01 0.715 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.927698e-01 0.715 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.376339e-01 0.861 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.376339e-01 0.861 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.376339e-01 0.861 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.098942e-01 0.678 0 0
Removal of the Flap Intermediate R-HSA-69166 2.098942e-01 0.678 0 0
STAT5 Activation R-HSA-9645135 3.468852e-01 0.460 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.468852e-01 0.460 0 0
FGFR2 alternative splicing R-HSA-6803529 1.485389e-01 0.828 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.597112e-01 0.797 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.711293e-01 0.767 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.445229e-01 0.612 0 0
Dual Incision in GG-NER R-HSA-5696400 1.320025e-01 0.879 0 0
PERK regulates gene expression R-HSA-381042 1.403828e-01 0.853 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.619322e-01 0.582 0 0
MET activates PTK2 signaling R-HSA-8874081 1.946171e-01 0.711 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.066450e-01 0.685 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.066450e-01 0.685 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.793480e-01 0.554 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.793480e-01 0.554 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.188349e-01 0.660 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.188349e-01 0.660 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.188349e-01 0.660 0 0
HIV elongation arrest and recovery R-HSA-167287 2.188349e-01 0.660 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.188349e-01 0.660 0 0
GAB1 signalosome R-HSA-180292 2.967327e-01 0.528 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.967327e-01 0.528 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.967327e-01 0.528 0 0
mRNA Capping R-HSA-72086 2.311671e-01 0.636 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.311671e-01 0.636 0 0
Attenuation phase R-HSA-3371568 1.851735e-01 0.732 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.140520e-01 0.503 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.140520e-01 0.503 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.140520e-01 0.503 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.561811e-01 0.591 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.140007e-01 0.670 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.312747e-01 0.480 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.312747e-01 0.480 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.312747e-01 0.480 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.312747e-01 0.480 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.312747e-01 0.480 0 0
Transcription of the HIV genome R-HSA-167172 1.549219e-01 0.810 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.892202e-01 0.723 0 0
Dual incision in TC-NER R-HSA-6782135 2.055212e-01 0.687 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.818805e-01 0.740 0 0
Striated Muscle Contraction R-HSA-390522 2.943041e-01 0.531 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.541461e-01 0.595 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.541461e-01 0.595 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.071041e-01 0.513 0 0
RUNX2 regulates bone development R-HSA-8941326 3.327479e-01 0.478 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.327479e-01 0.478 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.837116e-01 0.736 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.167331e-01 0.499 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.273190e-01 0.485 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.273190e-01 0.485 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.379255e-01 0.471 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.608219e-01 0.584 0 0
PTEN Regulation R-HSA-6807070 1.267814e-01 0.897 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.066450e-01 0.685 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.124115e-01 0.673 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.667185e-01 0.778 0 0
Integrin signaling R-HSA-354192 2.815394e-01 0.550 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.071041e-01 0.513 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.414800e-01 0.617 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.271618e-01 0.644 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.188683e-01 0.925 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.293916e-01 0.888 0 0
Co-stimulation by CD28 R-HSA-389356 2.747700e-01 0.561 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.428249e-01 0.845 0 0
Activation of C3 and C5 R-HSA-174577 2.820208e-01 0.550 0 0
Regulation of Apoptosis R-HSA-169911 3.199237e-01 0.495 0 0
RNA Polymerase III Transcription R-HSA-74158 3.327479e-01 0.478 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.376339e-01 0.861 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 1.485389e-01 0.828 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.320025e-01 0.879 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 1.827716e-01 0.738 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 2.188349e-01 0.660 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.943041e-01 0.531 0 0
Regulation of gap junction activity R-HSA-191650 2.472147e-01 0.607 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.815394e-01 0.550 0 0
Degradation of AXIN R-HSA-4641257 3.455627e-01 0.461 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.420075e-01 0.466 0 0
Nuclear RNA decay R-HSA-9930044 2.815394e-01 0.550 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.468852e-01 0.460 0 0
Long-term potentiation R-HSA-9620244 1.827716e-01 0.738 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.332854e-01 0.875 0 0
Signalling to RAS R-HSA-167044 1.270181e-01 0.896 0 0
Frs2-mediated activation R-HSA-170968 1.927698e-01 0.715 1 1
PTK6 Activates STAT3 R-HSA-8849474 2.820208e-01 0.550 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.820208e-01 0.550 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.820208e-01 0.550 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.820208e-01 0.550 0 0
Activation of AKT2 R-HSA-165158 2.820208e-01 0.550 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.152196e-01 0.501 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.619322e-01 0.582 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.436220e-01 0.613 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.815394e-01 0.550 0 0
PI3K Cascade R-HSA-109704 2.956573e-01 0.529 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.344687e-01 0.476 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.403828e-01 0.853 0 0
Chromosome Maintenance R-HSA-73886 3.106017e-01 0.508 0 0
L1CAM interactions R-HSA-373760 1.679970e-01 0.775 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.927698e-01 0.715 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.403828e-01 0.853 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.249743e-01 0.903 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.089386e-01 0.680 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.644437e-01 0.784 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.152196e-01 0.501 0 0
MET Receptor Activation R-HSA-6806942 3.468852e-01 0.460 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.271618e-01 0.644 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.238372e-01 0.907 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.946171e-01 0.711 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.312747e-01 0.480 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.196556e-01 0.922 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.199809e-01 0.921 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.329699e-01 0.876 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.946171e-01 0.711 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.967327e-01 0.528 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.140520e-01 0.503 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.302119e-01 0.481 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.238743e-01 0.650 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.191187e-01 0.659 0 0
DNA Double Strand Break Response R-HSA-5693606 2.836428e-01 0.547 0 0
Signaling by FGFR R-HSA-190236 2.608219e-01 0.584 1 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.107235e-01 0.676 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.107235e-01 0.676 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.472147e-01 0.607 0 0
vRNP Assembly R-HSA-192905 1.428249e-01 0.845 0 0
PDE3B signalling R-HSA-165160 3.152196e-01 0.501 0 0
PKB-mediated events R-HSA-109703 3.152196e-01 0.501 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.152196e-01 0.501 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.152196e-01 0.501 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.927698e-01 0.715 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.376339e-01 0.861 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.468852e-01 0.460 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.711293e-01 0.767 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.320025e-01 0.879 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.619322e-01 0.582 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.946171e-01 0.711 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.188349e-01 0.660 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.967327e-01 0.528 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.140520e-01 0.503 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.167331e-01 0.499 0 0
Meiosis R-HSA-1500620 2.799288e-01 0.553 0 0
DNA Replication R-HSA-69306 1.922914e-01 0.716 0 0
Co-inhibition by PD-1 R-HSA-389948 3.446729e-01 0.463 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.978632e-01 0.526 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.158959e-01 0.936 0 0
Signaling by FGFR2 R-HSA-5654738 1.279072e-01 0.893 1 0
Prolonged ERK activation events R-HSA-169893 2.445229e-01 0.612 1 0
Polo-like kinase mediated events R-HSA-156711 2.967327e-01 0.528 0 0
Interleukin-35 Signalling R-HSA-8984722 1.758431e-01 0.755 0 0
Autophagy R-HSA-9612973 1.283517e-01 0.892 0 0
DAP12 interactions R-HSA-2172127 2.338631e-01 0.631 0 0
Signaling by FGFR4 R-HSA-5654743 2.238743e-01 0.650 1 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.159966e-01 0.936 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.159966e-01 0.936 0 0
Interferon gamma signaling R-HSA-877300 1.397380e-01 0.855 0 0
Rap1 signalling R-HSA-392517 3.140520e-01 0.503 0 0
Vesicle-mediated transport R-HSA-5653656 1.520444e-01 0.818 0 0
Signaling by FGFR3 R-HSA-5654741 2.439570e-01 0.613 1 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.711293e-01 0.767 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.960145e-01 0.708 0 0
Interleukin-15 signaling R-HSA-8983432 1.758431e-01 0.755 0 0
HDMs demethylate histones R-HSA-3214842 1.827716e-01 0.738 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.042526e-01 0.690 1 1
rRNA processing R-HSA-72312 3.096490e-01 0.509 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.472147e-01 0.607 0 0
p38MAPK events R-HSA-171007 2.271618e-01 0.644 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.271618e-01 0.644 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.445229e-01 0.612 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.667185e-01 0.778 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.815394e-01 0.550 0 0
Cilium Assembly R-HSA-5617833 1.262120e-01 0.899 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.108963e-01 0.507 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.158959e-01 0.936 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.421553e-01 0.847 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.066450e-01 0.685 0 0
MTOR signalling R-HSA-165159 2.140007e-01 0.670 0 0
Cellular Senescence R-HSA-2559583 2.381508e-01 0.623 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.758431e-01 0.755 0 0
Downstream TCR signaling R-HSA-202424 3.287365e-01 0.483 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.946401e-01 0.711 0 0
Platelet degranulation R-HSA-114608 2.344295e-01 0.630 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.158959e-01 0.936 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.455627e-01 0.461 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.737519e-01 0.760 0 0
IGF1R signaling cascade R-HSA-2428924 1.298991e-01 0.886 0 0
Macroautophagy R-HSA-1632852 2.200648e-01 0.657 0 0
Signaling by NOTCH R-HSA-157118 1.167895e-01 0.933 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.107235e-01 0.676 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.428249e-01 0.845 0 0
Inositol transporters R-HSA-429593 2.820208e-01 0.550 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.758431e-01 0.755 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.152196e-01 0.501 1 1
Hydrolysis of LPE R-HSA-1483152 3.468852e-01 0.460 0 0
Other semaphorin interactions R-HSA-416700 2.271618e-01 0.644 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.238372e-01 0.907 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.238372e-01 0.907 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.359618e-01 0.867 0 0
ESR-mediated signaling R-HSA-8939211 1.657734e-01 0.780 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.348779e-01 0.629 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.677946e-01 0.775 0 0
Signaling by TGFB family members R-HSA-9006936 2.272423e-01 0.644 0 0
Degradation of CDH1 R-HSA-9766229 2.851855e-01 0.545 0 0
Ub-specific processing proteases R-HSA-5689880 3.035388e-01 0.518 0 0
Immune System R-HSA-168256 3.022261e-01 0.520 0 0
Cell junction organization R-HSA-446728 1.209851e-01 0.917 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.633809e-01 0.579 0 0
FLT3 signaling in disease R-HSA-9682385 3.327479e-01 0.478 0 0
Interleukin-1 signaling R-HSA-9020702 2.824713e-01 0.549 0 0
PECAM1 interactions R-HSA-210990 1.428249e-01 0.845 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.468852e-01 0.460 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.549219e-01 0.810 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.199237e-01 0.495 0 0
Chromatin organization R-HSA-4839726 2.964616e-01 0.528 0 0
Chromatin modifying enzymes R-HSA-3247509 2.282958e-01 0.642 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.949492e-01 0.710 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.108963e-01 0.507 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.946171e-01 0.711 0 0
Cell-Cell communication R-HSA-1500931 1.239313e-01 0.907 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.394030e-01 0.621 0 0
Reproduction R-HSA-1474165 1.594332e-01 0.797 0 0
Signaling by NOTCH3 R-HSA-9012852 1.812510e-01 0.742 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.633508e-01 0.579 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.403828e-01 0.853 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.793480e-01 0.554 0 0
Diseases of DNA repair R-HSA-9675135 1.159966e-01 0.936 0 0
Deubiquitination R-HSA-5688426 3.253319e-01 0.488 0 0
Opioid Signalling R-HSA-111885 3.045379e-01 0.516 0 0
Dopamine receptors R-HSA-390651 2.472147e-01 0.607 0 0
Interleukin-27 signaling R-HSA-9020956 1.268681e-01 0.897 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.268681e-01 0.897 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.428249e-01 0.845 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.591733e-01 0.798 0 0
Polymerase switching R-HSA-69091 1.758431e-01 0.755 0 0
Leading Strand Synthesis R-HSA-69109 1.758431e-01 0.755 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.152196e-01 0.501 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.152196e-01 0.501 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 3.152196e-01 0.501 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.152196e-01 0.501 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.927698e-01 0.715 0 0
CREB phosphorylation R-HSA-199920 3.468852e-01 0.460 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.271618e-01 0.644 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.619322e-01 0.582 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.066450e-01 0.685 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.681731e-01 0.774 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.815394e-01 0.550 0 0
Selective autophagy R-HSA-9663891 1.800976e-01 0.744 0 0
Insulin receptor signalling cascade R-HSA-74751 1.298991e-01 0.886 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.140007e-01 0.670 0 0
Nephrin family interactions R-HSA-373753 1.167132e-01 0.933 0 0
Sensory processing of sound R-HSA-9659379 2.330073e-01 0.633 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.292603e-01 0.482 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.239700e-01 0.907 0 0
Signaling by PTK6 R-HSA-8848021 1.239700e-01 0.907 0 0
Gene Silencing by RNA R-HSA-211000 1.163112e-01 0.934 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.758431e-01 0.755 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.270181e-01 0.896 0 0
G-protein mediated events R-HSA-112040 1.484764e-01 0.828 0 0
Interleukin-12 family signaling R-HSA-447115 3.041548e-01 0.517 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.338631e-01 0.631 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.820208e-01 0.550 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.820208e-01 0.550 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.758431e-01 0.755 0 0
Syndecan interactions R-HSA-3000170 1.597112e-01 0.797 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.758629e-01 0.755 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.167331e-01 0.499 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.679866e-01 0.572 0 0
PI Metabolism R-HSA-1483255 2.897848e-01 0.538 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.784019e-01 0.749 0 0
Signaling by ROBO receptors R-HSA-376176 1.736286e-01 0.760 0 0
Signaling by NOTCH2 R-HSA-1980145 3.071041e-01 0.513 0 0
Interleukin-6 family signaling R-HSA-6783589 1.711293e-01 0.767 0 0
Inositol phosphate metabolism R-HSA-1483249 1.385957e-01 0.858 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.268681e-01 0.897 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.098942e-01 0.678 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.892202e-01 0.723 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.428249e-01 0.845 0 0
Zinc transporters R-HSA-435354 2.098942e-01 0.678 0 0
Glucose metabolism R-HSA-70326 1.731633e-01 0.762 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 2.820208e-01 0.550 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.820208e-01 0.550 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.239700e-01 0.907 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.781087e-01 0.749 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.967327e-01 0.528 0 0
Disorders of transmembrane transporters R-HSA-5619115 2.870141e-01 0.542 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 2.472147e-01 0.607 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 3.468852e-01 0.460 0 0
Erythropoietin activates RAS R-HSA-9027284 2.271618e-01 0.644 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.892202e-01 0.723 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.581398e-01 0.801 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.133296e-01 0.504 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.445229e-01 0.612 0 0
Nephron development R-HSA-9831926 2.967327e-01 0.528 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.384833e-01 0.470 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.330073e-01 0.633 0 0
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763 3.468852e-01 0.460 0 0
FOXO-mediated transcription R-HSA-9614085 2.679866e-01 0.572 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.631889e-01 0.787 0 0
SARS-CoV Infections R-HSA-9679506 2.010682e-01 0.697 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.149719e-01 0.502 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.483730e-01 0.458 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.483730e-01 0.458 0 0
Lagging Strand Synthesis R-HSA-69186 3.483730e-01 0.458 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.483730e-01 0.458 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.483730e-01 0.458 0 0
Basigin interactions R-HSA-210991 3.483730e-01 0.458 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.485440e-01 0.458 0 0
Protein folding R-HSA-391251 3.535609e-01 0.452 0 0
Signaling by Insulin receptor R-HSA-74752 3.535609e-01 0.452 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.541096e-01 0.451 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.591663e-01 0.445 0 0
Signaling by FGFR1 R-HSA-5654736 3.591663e-01 0.445 1 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.591663e-01 0.445 0 0
NRAGE signals death through JNK R-HSA-193648 3.591663e-01 0.445 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.615861e-01 0.442 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.653214e-01 0.437 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.653214e-01 0.437 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.653214e-01 0.437 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.653214e-01 0.437 0 0
Regulation of CDH1 Function R-HSA-9764561 3.697846e-01 0.432 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.701909e-01 0.432 0 0
Stabilization of p53 R-HSA-69541 3.711099e-01 0.430 0 0
RAS processing R-HSA-9648002 3.711099e-01 0.430 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.711099e-01 0.430 0 0
Viral Infection Pathways R-HSA-9824446 3.727665e-01 0.429 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.770884e-01 0.424 0 0
Regulation of PTEN localization R-HSA-8948747 3.770884e-01 0.424 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.770884e-01 0.424 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.770884e-01 0.424 0 0
Disinhibition of SNARE formation R-HSA-114516 3.770884e-01 0.424 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.770884e-01 0.424 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.770884e-01 0.424 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.770884e-01 0.424 0 0
CHL1 interactions R-HSA-447041 3.770884e-01 0.424 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.770884e-01 0.424 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.770884e-01 0.424 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 3.770884e-01 0.424 0 0
SLC transporter disorders R-HSA-5619102 3.800636e-01 0.420 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.805575e-01 0.420 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.820973e-01 0.418 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.820973e-01 0.418 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.820973e-01 0.418 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.820973e-01 0.418 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.820973e-01 0.418 0 0
mTORC1-mediated signalling R-HSA-166208 3.820973e-01 0.418 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.820973e-01 0.418 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.820973e-01 0.418 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.838173e-01 0.416 0 0
Diseases of Immune System R-HSA-5260271 3.838173e-01 0.416 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.838173e-01 0.416 0 0
Integrin cell surface interactions R-HSA-216083 3.847845e-01 0.415 0 0
ABC transporter disorders R-HSA-5619084 3.847845e-01 0.415 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.871408e-01 0.412 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.876282e-01 0.412 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.909786e-01 0.408 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.951779e-01 0.403 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.951779e-01 0.403 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.952586e-01 0.403 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.964650e-01 0.402 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.964650e-01 0.402 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.964650e-01 0.402 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.986805e-01 0.399 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.986805e-01 0.399 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.986805e-01 0.399 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.986805e-01 0.399 0 0
Interleukin-20 family signaling R-HSA-8854691 3.986805e-01 0.399 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.986805e-01 0.399 0 0
Growth hormone receptor signaling R-HSA-982772 3.986805e-01 0.399 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.015396e-01 0.396 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.017964e-01 0.396 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.032929e-01 0.394 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.035030e-01 0.394 0 0
Type I hemidesmosome assembly R-HSA-446107 4.058967e-01 0.392 0 0
RSK activation R-HSA-444257 4.058967e-01 0.392 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.058967e-01 0.392 0 0
Formation of annular gap junctions R-HSA-196025 4.058967e-01 0.392 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.058967e-01 0.392 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.058967e-01 0.392 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.058967e-01 0.392 0 0
Interleukin-23 signaling R-HSA-9020933 4.058967e-01 0.392 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.058967e-01 0.392 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.058967e-01 0.392 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.058967e-01 0.392 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.058967e-01 0.392 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.058967e-01 0.392 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.090419e-01 0.388 0 0
HIV Transcription Initiation R-HSA-167161 4.090419e-01 0.388 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.090419e-01 0.388 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.090419e-01 0.388 0 0
Toll-like Receptor Cascades R-HSA-168898 4.090602e-01 0.388 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.150529e-01 0.382 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.150529e-01 0.382 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.150529e-01 0.382 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.150529e-01 0.382 0 0
Neurodegenerative Diseases R-HSA-8863678 4.150529e-01 0.382 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.215379e-01 0.375 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.225553e-01 0.374 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.225553e-01 0.374 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.225553e-01 0.374 0 0
Heme signaling R-HSA-9707616 4.225553e-01 0.374 0 0
ABC-family proteins mediated transport R-HSA-382556 4.284158e-01 0.368 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 4.311987e-01 0.365 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.311987e-01 0.365 0 0
Laminin interactions R-HSA-3000157 4.311987e-01 0.365 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.311987e-01 0.365 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.311987e-01 0.365 0 0
G protein gated Potassium channels R-HSA-1296059 4.311987e-01 0.365 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.311987e-01 0.365 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.311987e-01 0.365 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.311987e-01 0.365 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.311987e-01 0.365 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.333742e-01 0.363 0 0
Gap junction degradation R-HSA-190873 4.333742e-01 0.363 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.333742e-01 0.363 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.333742e-01 0.363 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.333742e-01 0.363 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 4.333742e-01 0.363 0 0
Interleukin-1 processing R-HSA-448706 4.333742e-01 0.363 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.333742e-01 0.363 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.333742e-01 0.363 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.339433e-01 0.363 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.339433e-01 0.363 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.409415e-01 0.356 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.409415e-01 0.356 0 0
Disease R-HSA-1643685 4.414362e-01 0.355 1 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.433864e-01 0.353 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.449379e-01 0.352 0 0
Proteasome assembly R-HSA-9907900 4.462490e-01 0.350 0 0
Methylation R-HSA-156581 4.462490e-01 0.350 0 0
Cyclin D associated events in G1 R-HSA-69231 4.462490e-01 0.350 0 0
G1 Phase R-HSA-69236 4.462490e-01 0.350 0 0
Amine ligand-binding receptors R-HSA-375280 4.462490e-01 0.350 0 0
Post-translational protein modification R-HSA-597592 4.466571e-01 0.350 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.471036e-01 0.350 0 0
TRP channels R-HSA-3295583 4.471036e-01 0.350 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.491909e-01 0.348 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.494674e-01 0.347 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.537176e-01 0.343 0 0
Parasitic Infection Pathways R-HSA-9824443 4.555875e-01 0.341 0 0
Leishmania infection R-HSA-9658195 4.555875e-01 0.341 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.571769e-01 0.340 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.584466e-01 0.339 0 0
Nucleosome assembly R-HSA-774815 4.584466e-01 0.339 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.584466e-01 0.339 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.584466e-01 0.339 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.584466e-01 0.339 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.584466e-01 0.339 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 4.595825e-01 0.338 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.595825e-01 0.338 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.595825e-01 0.338 0 0
2-LTR circle formation R-HSA-164843 4.595825e-01 0.338 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.595825e-01 0.338 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 4.595825e-01 0.338 0 0
Signaling by Leptin R-HSA-2586552 4.595825e-01 0.338 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.595825e-01 0.338 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.613603e-01 0.336 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.627557e-01 0.335 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.627557e-01 0.335 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.627557e-01 0.335 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.627557e-01 0.335 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.627557e-01 0.335 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.635977e-01 0.334 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.635977e-01 0.334 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.705283e-01 0.327 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.705283e-01 0.327 0 0
Signaling by TGFBR3 R-HSA-9839373 4.705283e-01 0.327 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.744321e-01 0.324 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.762985e-01 0.322 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.776581e-01 0.321 0 0
Developmental Biology R-HSA-1266738 4.779807e-01 0.321 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.781441e-01 0.320 0 0
Pyroptosis R-HSA-5620971 4.781441e-01 0.320 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.824867e-01 0.317 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.843077e-01 0.315 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.843077e-01 0.315 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.845801e-01 0.315 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.845801e-01 0.315 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.845801e-01 0.315 0 0
Conjugation of benzoate with glycine R-HSA-177135 4.845801e-01 0.315 0 0
vRNA Synthesis R-HSA-192814 4.845801e-01 0.315 0 0
Bicarbonate transporters R-HSA-425381 4.845801e-01 0.315 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.845801e-01 0.315 0 0
Suppression of apoptosis R-HSA-9635465 4.845801e-01 0.315 0 0
Transport of RCbl within the body R-HSA-9758890 4.845801e-01 0.315 0 0
Interleukin-2 signaling R-HSA-9020558 4.845801e-01 0.315 0 0
Late endosomal microautophagy R-HSA-9615710 4.932598e-01 0.307 0 0
Platelet calcium homeostasis R-HSA-418360 4.932598e-01 0.307 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.932598e-01 0.307 0 0
ER-Phagosome pathway R-HSA-1236974 4.941245e-01 0.306 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.018209e-01 0.299 0 0
Base Excision Repair R-HSA-73884 5.029532e-01 0.298 0 0
COPII-mediated vesicle transport R-HSA-204005 5.043152e-01 0.297 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.060075e-01 0.296 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.060075e-01 0.296 0 0
DNA Damage Bypass R-HSA-73893 5.060075e-01 0.296 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.080952e-01 0.294 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.080952e-01 0.294 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.084229e-01 0.294 0 0
NF-kB is activated and signals survival R-HSA-209560 5.084229e-01 0.294 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.084229e-01 0.294 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.084229e-01 0.294 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.084229e-01 0.294 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.084229e-01 0.294 0 0
Activation of RAC1 R-HSA-428540 5.084229e-01 0.294 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.084229e-01 0.294 0 0
Integration of provirus R-HSA-162592 5.084229e-01 0.294 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 5.084229e-01 0.294 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 5.084229e-01 0.294 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.141896e-01 0.289 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.141896e-01 0.289 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.141896e-01 0.289 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.155237e-01 0.288 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.177089e-01 0.286 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.177089e-01 0.286 0 0
Cargo concentration in the ER R-HSA-5694530 5.226438e-01 0.282 0 0
Trafficking of AMPA receptors R-HSA-399719 5.226438e-01 0.282 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.226438e-01 0.282 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.226438e-01 0.282 0 0
Signaling by NTRKs R-HSA-166520 5.272777e-01 0.278 1 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.289610e-01 0.277 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.289610e-01 0.277 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.311641e-01 0.275 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.311641e-01 0.275 0 0
Conjugation of salicylate with glycine R-HSA-177128 5.311641e-01 0.275 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.311641e-01 0.275 0 0
Synthesis of GDP-mannose R-HSA-446205 5.311641e-01 0.275 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.311641e-01 0.275 0 0
Pervasive developmental disorders R-HSA-9005895 5.311641e-01 0.275 0 0
Disorders of Nervous System Development R-HSA-9697154 5.311641e-01 0.275 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.311641e-01 0.275 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 5.311641e-01 0.275 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.311641e-01 0.275 0 0
OAS antiviral response R-HSA-8983711 5.311641e-01 0.275 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.369004e-01 0.270 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.369004e-01 0.270 0 0
tRNA processing R-HSA-72306 5.376258e-01 0.270 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.383714e-01 0.269 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.402124e-01 0.267 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.402124e-01 0.267 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.411610e-01 0.267 0 0
Signaling by ERBB4 R-HSA-1236394 5.432478e-01 0.265 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.508610e-01 0.259 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.513076e-01 0.259 0 0
Protein ubiquitination R-HSA-8852135 5.527338e-01 0.257 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.527338e-01 0.257 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.528545e-01 0.257 0 0
Formation of axial mesoderm R-HSA-9796292 5.528545e-01 0.257 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.528545e-01 0.257 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.528545e-01 0.257 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.528545e-01 0.257 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.528545e-01 0.257 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.528545e-01 0.257 0 0
Maturation of nucleoprotein R-HSA-9683610 5.528545e-01 0.257 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.528545e-01 0.257 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.545464e-01 0.256 0 0
UCH proteinases R-HSA-5689603 5.621144e-01 0.250 0 0
Interleukin-12 signaling R-HSA-9020591 5.621144e-01 0.250 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.628896e-01 0.250 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.641044e-01 0.249 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.645223e-01 0.248 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 5.645223e-01 0.248 0 0
HCMV Early Events R-HSA-9609690 5.645966e-01 0.248 0 0
Death Receptor Signaling R-HSA-73887 5.671206e-01 0.246 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.711533e-01 0.243 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.711533e-01 0.243 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.713868e-01 0.243 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.735428e-01 0.241 0 0
Regulation of KIT signaling R-HSA-1433559 5.735428e-01 0.241 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.735428e-01 0.241 0 0
Hydrolysis of LPC R-HSA-1483115 5.735428e-01 0.241 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.735428e-01 0.241 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.778822e-01 0.238 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.778822e-01 0.238 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.778822e-01 0.238 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 5.778822e-01 0.238 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.778822e-01 0.238 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.778822e-01 0.238 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.790911e-01 0.237 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.790911e-01 0.237 0 0
Telomere Maintenance R-HSA-157579 5.793352e-01 0.237 0 0
RNA Polymerase I Transcription R-HSA-73864 5.805483e-01 0.236 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.836201e-01 0.234 0 0
Ion homeostasis R-HSA-5578775 5.836201e-01 0.234 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.874334e-01 0.231 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.874334e-01 0.231 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.874334e-01 0.231 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.909393e-01 0.228 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.909393e-01 0.228 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.932750e-01 0.227 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.932750e-01 0.227 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.932750e-01 0.227 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.932750e-01 0.227 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.932750e-01 0.227 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.932750e-01 0.227 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.932750e-01 0.227 0 0
Protein repair R-HSA-5676934 5.932750e-01 0.227 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.932750e-01 0.227 0 0
Protein methylation R-HSA-8876725 5.932750e-01 0.227 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.932750e-01 0.227 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.932750e-01 0.227 0 0
p75NTR signals via NF-kB R-HSA-193639 5.932750e-01 0.227 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.932750e-01 0.227 0 0
Formation of the anterior neural plate R-HSA-9823739 5.932750e-01 0.227 0 0
PKR-mediated signaling R-HSA-9833482 5.985294e-01 0.223 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.036931e-01 0.219 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.036931e-01 0.219 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.036931e-01 0.219 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 6.036931e-01 0.219 0 0
GPVI-mediated activation cascade R-HSA-114604 6.036931e-01 0.219 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.036931e-01 0.219 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.047008e-01 0.218 0 0
Regulation of TP53 Activity R-HSA-5633007 6.054122e-01 0.218 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.073447e-01 0.217 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.112072e-01 0.214 0 0
Phosphorylation of the APC/C R-HSA-176412 6.120953e-01 0.213 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.120953e-01 0.213 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.120953e-01 0.213 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.120953e-01 0.213 0 0
Differentiation of T cells R-HSA-9945266 6.120953e-01 0.213 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.120953e-01 0.213 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.120953e-01 0.213 0 0
Activation of SMO R-HSA-5635838 6.120953e-01 0.213 0 0
Atorvastatin ADME R-HSA-9754706 6.120953e-01 0.213 0 0
Leishmania phagocytosis R-HSA-9664417 6.130827e-01 0.212 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.130827e-01 0.212 0 0
Parasite infection R-HSA-9664407 6.130827e-01 0.212 0 0
Extension of Telomeres R-HSA-180786 6.144131e-01 0.212 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.160408e-01 0.210 0 0
Degradation of DVL R-HSA-4641258 6.161437e-01 0.210 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.161437e-01 0.210 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.161437e-01 0.210 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.161437e-01 0.210 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.189527e-01 0.208 0 0
Kinesins R-HSA-983189 6.243300e-01 0.205 0 0
Elastic fibre formation R-HSA-1566948 6.282918e-01 0.202 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.282918e-01 0.202 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.293924e-01 0.201 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.300459e-01 0.201 0 0
Fibronectin matrix formation R-HSA-1566977 6.300459e-01 0.201 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 6.300459e-01 0.201 0 0
Phase 2 - plateau phase R-HSA-5576893 6.300459e-01 0.201 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.300459e-01 0.201 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.300459e-01 0.201 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.300459e-01 0.201 0 0
Galactose catabolism R-HSA-70370 6.300459e-01 0.201 0 0
Disorders of Developmental Biology R-HSA-9675151 6.300459e-01 0.201 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.300459e-01 0.201 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.330687e-01 0.199 0 0
MAP kinase activation R-HSA-450294 6.340707e-01 0.198 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.340707e-01 0.198 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.341666e-01 0.198 0 0
Signaling by ALK R-HSA-201556 6.401387e-01 0.194 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.401387e-01 0.194 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.401387e-01 0.194 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.401387e-01 0.194 0 0
Pentose phosphate pathway R-HSA-71336 6.401387e-01 0.194 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.401387e-01 0.194 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.416325e-01 0.193 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.416325e-01 0.193 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.471669e-01 0.189 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.471669e-01 0.189 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.471669e-01 0.189 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.471669e-01 0.189 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.471669e-01 0.189 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.471669e-01 0.189 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.471669e-01 0.189 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.471669e-01 0.189 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.496023e-01 0.187 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.516863e-01 0.186 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.516863e-01 0.186 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.516863e-01 0.186 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.530201e-01 0.185 0 0
Transmission across Chemical Synapses R-HSA-112315 6.558037e-01 0.183 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.576811e-01 0.182 0 0
Muscle contraction R-HSA-397014 6.586984e-01 0.181 0 0
Adaptive Immune System R-HSA-1280218 6.621454e-01 0.179 0 0
Ion transport by P-type ATPases R-HSA-936837 6.622277e-01 0.179 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.629369e-01 0.179 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.629369e-01 0.179 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.629369e-01 0.179 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.634965e-01 0.178 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.634965e-01 0.178 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.634965e-01 0.178 0 0
Apoptotic factor-mediated response R-HSA-111471 6.634965e-01 0.178 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.634965e-01 0.178 0 0
Innate Immune System R-HSA-168249 6.654557e-01 0.177 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.705328e-01 0.174 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.705328e-01 0.174 0 0
Peptide chain elongation R-HSA-156902 6.734588e-01 0.172 0 0
Diseases of programmed cell death R-HSA-9645723 6.734588e-01 0.172 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.738932e-01 0.171 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.738932e-01 0.171 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.738932e-01 0.171 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.738932e-01 0.171 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.738932e-01 0.171 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.738932e-01 0.171 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.764203e-01 0.170 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.775131e-01 0.169 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.790713e-01 0.168 0 0
Regulation of signaling by CBL R-HSA-912631 6.790713e-01 0.168 0 0
Amino Acid conjugation R-HSA-156587 6.790713e-01 0.168 0 0
Conjugation of carboxylic acids R-HSA-159424 6.790713e-01 0.168 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.790713e-01 0.168 0 0
Diseases of hemostasis R-HSA-9671793 6.790713e-01 0.168 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.790713e-01 0.168 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.790713e-01 0.168 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.790713e-01 0.168 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.790713e-01 0.168 0 0
Maturation of nucleoprotein R-HSA-9694631 6.790713e-01 0.168 0 0
Other interleukin signaling R-HSA-449836 6.790713e-01 0.168 0 0
Potential therapeutics for SARS R-HSA-9679191 6.817239e-01 0.166 0 0
Activation of GABAB receptors R-HSA-991365 6.845585e-01 0.165 0 0
GABA B receptor activation R-HSA-977444 6.845585e-01 0.165 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.874600e-01 0.163 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.874600e-01 0.163 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.880031e-01 0.162 0 0
Kidney development R-HSA-9830369 6.887805e-01 0.162 0 0
Adherens junctions interactions R-HSA-418990 6.889990e-01 0.162 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.933371e-01 0.159 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.939261e-01 0.159 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.939261e-01 0.159 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.939261e-01 0.159 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.939261e-01 0.159 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.939261e-01 0.159 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.939261e-01 0.159 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.939261e-01 0.159 0 0
Glycogen synthesis R-HSA-3322077 6.939261e-01 0.159 0 0
Adipogenesis R-HSA-9843745 6.948094e-01 0.158 0 0
Defective pyroptosis R-HSA-9710421 6.949361e-01 0.158 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.961686e-01 0.157 0 0
Regulated Necrosis R-HSA-5218859 6.972757e-01 0.157 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.978572e-01 0.156 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.978572e-01 0.156 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.982610e-01 0.156 0 0
Circadian clock R-HSA-9909396 7.009081e-01 0.154 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.034824e-01 0.153 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.044385e-01 0.152 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.046728e-01 0.152 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.050298e-01 0.152 0 0
RMTs methylate histone arginines R-HSA-3214858 7.050298e-01 0.152 0 0
Netrin-1 signaling R-HSA-373752 7.050298e-01 0.152 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.055940e-01 0.151 0 0
G-protein activation R-HSA-202040 7.080942e-01 0.150 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.080942e-01 0.150 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.080942e-01 0.150 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.080942e-01 0.150 0 0
ERK/MAPK targets R-HSA-198753 7.080942e-01 0.150 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.080942e-01 0.150 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.080942e-01 0.150 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.082420e-01 0.150 0 0
Interleukin-17 signaling R-HSA-448424 7.137363e-01 0.146 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.148437e-01 0.146 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.148437e-01 0.146 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.148437e-01 0.146 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.148437e-01 0.146 0 0
Somitogenesis R-HSA-9824272 7.148437e-01 0.146 0 0
HCMV Late Events R-HSA-9610379 7.211508e-01 0.142 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.216073e-01 0.142 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.216073e-01 0.142 0 0
Glutathione synthesis and recycling R-HSA-174403 7.216073e-01 0.142 0 0
ECM proteoglycans R-HSA-3000178 7.217037e-01 0.142 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.217037e-01 0.142 0 0
Hedgehog 'on' state R-HSA-5632684 7.217037e-01 0.142 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.243820e-01 0.140 0 0
HCMV Infection R-HSA-9609646 7.307529e-01 0.136 0 0
Recycling pathway of L1 R-HSA-437239 7.336492e-01 0.135 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.336492e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.344956e-01 0.134 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.344956e-01 0.134 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.344956e-01 0.134 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.344956e-01 0.134 0 0
Cell-cell junction organization R-HSA-421270 7.350248e-01 0.134 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.357637e-01 0.133 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.381356e-01 0.132 0 0
Signaling by WNT R-HSA-195721 7.388333e-01 0.131 0 0
Ribosome-associated quality control R-HSA-9948299 7.412826e-01 0.130 0 0
Mitochondrial biogenesis R-HSA-1592230 7.418162e-01 0.130 0 0
Intraflagellar transport R-HSA-5620924 7.426499e-01 0.129 0 0
Metal ion SLC transporters R-HSA-425410 7.426499e-01 0.129 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.467880e-01 0.127 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.467880e-01 0.127 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.467880e-01 0.127 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.467880e-01 0.127 0 0
Formation of the ureteric bud R-HSA-9830674 7.467880e-01 0.127 0 0
Mitochondrial mRNA modification R-HSA-9937008 7.467880e-01 0.127 0 0
Gap junction trafficking and regulation R-HSA-157858 7.513890e-01 0.124 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.513890e-01 0.124 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.585119e-01 0.120 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.585119e-01 0.120 0 0
Deadenylation of mRNA R-HSA-429947 7.585119e-01 0.120 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.585119e-01 0.120 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.589634e-01 0.120 0 0
Azathioprine ADME R-HSA-9748787 7.598714e-01 0.119 0 0
HATs acetylate histones R-HSA-3214847 7.635858e-01 0.117 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.681020e-01 0.115 0 0
TGFBR3 expression R-HSA-9839394 7.696938e-01 0.114 0 0
Tight junction interactions R-HSA-420029 7.696938e-01 0.114 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.696938e-01 0.114 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.696938e-01 0.114 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.696938e-01 0.114 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 7.696938e-01 0.114 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.696938e-01 0.114 0 0
Infectious disease R-HSA-5663205 7.760804e-01 0.110 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 7.793175e-01 0.108 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.803585e-01 0.108 0 0
Myogenesis R-HSA-525793 7.803585e-01 0.108 0 0
Metalloprotease DUBs R-HSA-5689901 7.803585e-01 0.108 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.803585e-01 0.108 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 7.803585e-01 0.108 0 0
Sphingolipid catabolism R-HSA-9845614 7.803585e-01 0.108 0 0
Smooth Muscle Contraction R-HSA-445355 7.838286e-01 0.106 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.857801e-01 0.105 0 0
Cristae formation R-HSA-8949613 7.905300e-01 0.102 0 0
Translation initiation complex formation R-HSA-72649 7.913350e-01 0.102 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.926401e-01 0.101 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.986105e-01 0.098 0 0
Paracetamol ADME R-HSA-9753281 7.986105e-01 0.098 0 0
G alpha (z) signalling events R-HSA-418597 7.986105e-01 0.098 0 0
Telomere Extension By Telomerase R-HSA-171319 8.002310e-01 0.097 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.002310e-01 0.097 1 0
Pyrimidine salvage R-HSA-73614 8.002310e-01 0.097 0 0
Gastrulation R-HSA-9758941 8.011044e-01 0.096 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.042324e-01 0.095 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.094833e-01 0.092 1 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.094833e-01 0.092 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.183077e-01 0.087 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.183077e-01 0.087 0 0
Neurotransmitter clearance R-HSA-112311 8.183077e-01 0.087 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.183077e-01 0.087 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.187585e-01 0.087 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.191042e-01 0.087 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.191042e-01 0.087 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.191042e-01 0.087 0 0
Hemostasis R-HSA-109582 8.230285e-01 0.085 0 0
Cardiac conduction R-HSA-5576891 8.242237e-01 0.084 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.255087e-01 0.083 0 0
PPARA activates gene expression R-HSA-1989781 8.267167e-01 0.083 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.267238e-01 0.083 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.267238e-01 0.083 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.267238e-01 0.083 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.267238e-01 0.083 0 0
EGFR downregulation R-HSA-182971 8.267238e-01 0.083 0 0
GABA receptor activation R-HSA-977443 8.317086e-01 0.080 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.317086e-01 0.080 0 0
Metabolism of polyamines R-HSA-351202 8.317086e-01 0.080 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.346473e-01 0.078 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.347506e-01 0.078 0 0
Signaling by WNT in cancer R-HSA-4791275 8.347506e-01 0.078 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.376512e-01 0.077 0 0
Cellular response to starvation R-HSA-9711097 8.385020e-01 0.076 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.385020e-01 0.076 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.424060e-01 0.074 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.424060e-01 0.074 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.424060e-01 0.074 1 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.424060e-01 0.074 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.424060e-01 0.074 0 0
G-protein beta:gamma signalling R-HSA-397795 8.424060e-01 0.074 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.424060e-01 0.074 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.435155e-01 0.074 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.452652e-01 0.073 0 0
Neurotransmitter release cycle R-HSA-112310 8.469954e-01 0.072 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.497072e-01 0.071 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.497072e-01 0.071 0 0
Heme degradation R-HSA-189483 8.497072e-01 0.071 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.517266e-01 0.070 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.566706e-01 0.067 0 0
eNOS activation R-HSA-203615 8.566706e-01 0.067 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.566706e-01 0.067 1 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.566706e-01 0.067 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.566706e-01 0.067 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.566706e-01 0.067 0 0
Mitophagy R-HSA-5205647 8.566706e-01 0.067 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.594124e-01 0.066 0 0
Cellular response to hypoxia R-HSA-1234174 8.598197e-01 0.066 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.603577e-01 0.065 0 0
Developmental Cell Lineages R-HSA-9734767 8.607934e-01 0.065 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 8.633117e-01 0.064 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.633117e-01 0.064 0 0
G alpha (q) signalling events R-HSA-416476 8.635286e-01 0.064 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.735136e-01 0.059 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.756862e-01 0.058 0 0
Voltage gated Potassium channels R-HSA-1296072 8.756862e-01 0.058 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.756862e-01 0.058 0 0
Eukaryotic Translation Termination R-HSA-72764 8.775151e-01 0.057 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.808212e-01 0.055 0 0
Potassium Channels R-HSA-1296071 8.814038e-01 0.055 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.814473e-01 0.055 0 0
Biofilm formation R-HSA-9931953 8.814473e-01 0.055 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.814473e-01 0.055 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.835731e-01 0.054 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.835731e-01 0.054 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.835731e-01 0.054 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.878533e-01 0.052 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.878533e-01 0.052 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.879985e-01 0.052 0 0
MHC class II antigen presentation R-HSA-2132295 8.879985e-01 0.052 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.919872e-01 0.050 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.919872e-01 0.050 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.921819e-01 0.050 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.921819e-01 0.050 0 0
Glycogen metabolism R-HSA-8982491 8.921819e-01 0.050 0 0
Ca2+ pathway R-HSA-4086398 8.959792e-01 0.048 0 0
Aspirin ADME R-HSA-9749641 8.959792e-01 0.048 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.974729e-01 0.047 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.974729e-01 0.047 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.974729e-01 0.047 0 0
Selenocysteine synthesis R-HSA-2408557 8.992433e-01 0.046 0 0
Intra-Golgi traffic R-HSA-6811438 9.019456e-01 0.045 0 0
Translation of Structural Proteins R-HSA-9683701 9.019456e-01 0.045 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.035545e-01 0.044 0 0
Viral mRNA Translation R-HSA-192823 9.056756e-01 0.043 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.064912e-01 0.043 0 0
Depyrimidination R-HSA-73928 9.064912e-01 0.043 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.064912e-01 0.043 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.108263e-01 0.041 0 0
RSV-host interactions R-HSA-9833110 9.117343e-01 0.040 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.139567e-01 0.039 0 0
PCP/CE pathway R-HSA-4086400 9.139567e-01 0.039 0 0
Gap junction trafficking R-HSA-190828 9.149606e-01 0.039 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.149606e-01 0.039 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.189036e-01 0.037 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.189950e-01 0.037 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.193706e-01 0.037 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.201614e-01 0.036 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.226639e-01 0.035 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.226639e-01 0.035 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.226639e-01 0.035 0 0
Stimuli-sensing channels R-HSA-2672351 9.228029e-01 0.035 0 0
Amyloid fiber formation R-HSA-977225 9.232992e-01 0.035 0 0
Neuronal System R-HSA-112316 9.251746e-01 0.034 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.262501e-01 0.033 0 0
Ion channel transport R-HSA-983712 9.280022e-01 0.032 0 0
Phospholipid metabolism R-HSA-1483257 9.289872e-01 0.032 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.289874e-01 0.032 0 0
GPER1 signaling R-HSA-9634597 9.296702e-01 0.032 0 0
Gluconeogenesis R-HSA-70263 9.296702e-01 0.032 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.308343e-01 0.031 0 0
Integration of energy metabolism R-HSA-163685 9.308343e-01 0.031 0 0
Selenoamino acid metabolism R-HSA-2408522 9.315482e-01 0.031 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.342755e-01 0.030 0 0
Signaling by Hedgehog R-HSA-5358351 9.349922e-01 0.029 0 0
Neddylation R-HSA-8951664 9.379192e-01 0.028 0 0
Translation R-HSA-72766 9.389379e-01 0.027 0 0
Meiotic recombination R-HSA-912446 9.390090e-01 0.027 0 0
The phototransduction cascade R-HSA-2514856 9.390090e-01 0.027 0 0
Neurexins and neuroligins R-HSA-6794361 9.418381e-01 0.026 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.418381e-01 0.026 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.432114e-01 0.025 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.445362e-01 0.025 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.445362e-01 0.025 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.471092e-01 0.024 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.471092e-01 0.024 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.488286e-01 0.023 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.488286e-01 0.023 0 0
HDACs deacetylate histones R-HSA-3214815 9.495630e-01 0.022 0 0
TNF signaling R-HSA-75893 9.519031e-01 0.021 0 0
Dectin-2 family R-HSA-5621480 9.541348e-01 0.020 0 0
Synthesis of PA R-HSA-1483166 9.541348e-01 0.020 0 0
Metabolism of proteins R-HSA-392499 9.546343e-01 0.020 0 0
FCGR activation R-HSA-2029481 9.555678e-01 0.020 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.562631e-01 0.019 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.580251e-01 0.019 0 0
Peroxisomal protein import R-HSA-9033241 9.582927e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.582927e-01 0.019 0 0
Formation of the cornified envelope R-HSA-6809371 9.585168e-01 0.018 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.596156e-01 0.018 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.602283e-01 0.018 0 0
Glutathione conjugation R-HSA-156590 9.602283e-01 0.018 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.602283e-01 0.018 0 0
tRNA Aminoacylation R-HSA-379724 9.602283e-01 0.018 0 0
Nucleotide salvage R-HSA-8956321 9.620741e-01 0.017 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.626934e-01 0.017 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.638344e-01 0.016 0 0
Mitochondrial protein import R-HSA-1268020 9.638344e-01 0.016 0 0
Peptide ligand-binding receptors R-HSA-375276 9.653671e-01 0.015 0 0
Hedgehog 'off' state R-HSA-5610787 9.676759e-01 0.014 0 0
Extracellular matrix organization R-HSA-1474244 9.694196e-01 0.013 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.700965e-01 0.013 0 0
Nicotinate metabolism R-HSA-196807 9.714848e-01 0.013 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.714848e-01 0.013 0 0
GPCR downstream signalling R-HSA-388396 9.733500e-01 0.012 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.752754e-01 0.011 0 0
Platelet homeostasis R-HSA-418346 9.756082e-01 0.011 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.764236e-01 0.010 0 0
Metabolism of cofactors R-HSA-8978934 9.764236e-01 0.010 0 0
Metabolism of porphyrins R-HSA-189445 9.764236e-01 0.010 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.775186e-01 0.010 0 0
Purine catabolism R-HSA-74259 9.775186e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.822769e-01 0.008 0 0
Interleukin-10 signaling R-HSA-6783783 9.831003e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.831003e-01 0.007 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.846342e-01 0.007 0 0
Protein localization R-HSA-9609507 9.875206e-01 0.005 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.889878e-01 0.005 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.889878e-01 0.005 0 0
Pyruvate metabolism R-HSA-70268 9.894997e-01 0.005 0 0
Regulation of Complement cascade R-HSA-977606 9.896769e-01 0.005 0 0
Signaling by GPCR R-HSA-372790 9.907594e-01 0.004 0 0
Nucleotide catabolism R-HSA-8956319 9.916125e-01 0.004 0 0
IRE1alpha activates chaperones R-HSA-381070 9.917241e-01 0.004 0 0
Metabolism of steroids R-HSA-8957322 9.920438e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.921090e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.924760e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.928259e-01 0.003 0 0
Metabolism of nucleotides R-HSA-15869 9.932963e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.937812e-01 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 9.937812e-01 0.003 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.939420e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.946094e-01 0.002 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.947733e-01 0.002 0 0
Drug ADME R-HSA-9748784 9.961530e-01 0.002 0 0
Complement cascade R-HSA-166658 9.962224e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.969439e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.969575e-01 0.001 0 0
Bacterial Infection Pathways R-HSA-9824439 9.973172e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.974301e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.975233e-01 0.001 0 0
Initial triggering of complement R-HSA-166663 9.976029e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.978210e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.982605e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.983635e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.983973e-01 0.001 0 0
Keratinization R-HSA-6805567 9.985163e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.988078e-01 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.990771e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.991119e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.993205e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.993394e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.993702e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.996095e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996761e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.997580e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999267e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999359e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999745e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999761e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999991e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999993e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999994e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999995e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.000000e+00 0.000 1 1
ARMS-mediated activation R-HSA-170984 1.000000e+00 0.000 1 1
Signalling to p38 via RIT and RIN R-HSA-187706 1.000000e+00 0.000 1 1
Signaling by MRAS-complex mutants R-HSA-9660537 1.000000e+00 0.000 1 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.000000e+00 0.000 1 1
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.609935e-07 6.583 0 0
Cell Cycle R-HSA-1640170 6.568441e-07 6.183 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.780553e-06 5.556 0 0
mRNA 3'-end processing R-HSA-72187 3.566368e-06 5.448 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.944359e-06 5.048 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.545012e-06 5.068 0 0
NRAGE signals death through JNK R-HSA-193648 9.305441e-06 5.031 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.178877e-05 4.929 0 0
Cell Cycle, Mitotic R-HSA-69278 2.224331e-05 4.653 0 0
G alpha (12/13) signalling events R-HSA-416482 8.159188e-05 4.088 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.281720e-05 4.032 0 0
M Phase R-HSA-68886 1.228908e-04 3.910 0 0
Death Receptor Signaling R-HSA-73887 1.531874e-04 3.815 0 0
Specification of primordial germ cells R-HSA-9827857 1.642021e-04 3.785 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.031005e-04 3.692 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.988094e-04 3.525 0 0
Mitotic Anaphase R-HSA-68882 3.695251e-04 3.432 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.025259e-04 3.395 0 0
Kinesins R-HSA-983189 5.166674e-04 3.287 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.804560e-04 3.236 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.255804e-04 3.204 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.952505e-04 3.158 0 0
mRNA Splicing R-HSA-72172 8.100028e-04 3.092 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.415691e-04 3.075 0 0
Chromatin organization R-HSA-4839726 9.197447e-04 3.036 0 0
Chromatin modifying enzymes R-HSA-3247509 8.910858e-04 3.050 0 0
Mitotic Prometaphase R-HSA-68877 9.772727e-04 3.010 0 0
Cell Cycle Checkpoints R-HSA-69620 1.038481e-03 2.984 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.163364e-03 2.934 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.322778e-03 2.879 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.322778e-03 2.879 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.519101e-03 2.818 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.706707e-03 2.768 0 0
Interleukin-37 signaling R-HSA-9008059 2.036373e-03 2.691 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.167681e-03 2.664 0 0
Apoptotic execution phase R-HSA-75153 2.462863e-03 2.609 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.968043e-03 2.528 1 0
Amplification of signal from the kinetochores R-HSA-141424 3.398036e-03 2.469 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.398036e-03 2.469 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.264184e-03 2.486 0 0
PKA activation R-HSA-163615 3.738044e-03 2.427 0 0
PKA activation in glucagon signalling R-HSA-164378 3.738044e-03 2.427 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.523228e-03 2.453 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.607003e-03 2.337 0 0
Hedgehog 'off' state R-HSA-5610787 4.990780e-03 2.302 0 0
Separation of Sister Chromatids R-HSA-2467813 5.044087e-03 2.297 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.426913e-03 2.265 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.399736e-03 2.268 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.726314e-03 2.242 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.565105e-03 2.255 0 0
Signaling by ALK in cancer R-HSA-9700206 5.565105e-03 2.255 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.610088e-03 2.251 0 0
Neurodegenerative Diseases R-HSA-8863678 5.610088e-03 2.251 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.585449e-03 2.120 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.051238e-03 2.094 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.880965e-03 2.103 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.441024e-03 2.074 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.651017e-03 2.015 0 0
Signaling by Hedgehog R-HSA-5358351 1.047684e-02 1.980 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.004267e-02 1.998 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.061012e-02 1.974 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.119596e-02 1.951 1 1
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.080719e-02 1.966 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.080719e-02 1.966 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.158700e-02 1.936 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.273131e-02 1.895 0 0
Signal Transduction R-HSA-162582 1.249019e-02 1.903 1 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.284440e-02 1.891 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.366413e-02 1.864 0 0
Regulation of KIT signaling R-HSA-1433559 1.369757e-02 1.863 0 0
IRE1alpha activates chaperones R-HSA-381070 1.414157e-02 1.850 0 0
DARPP-32 events R-HSA-180024 1.420293e-02 1.848 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.511649e-02 1.821 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.554054e-02 1.809 0 0
Specification of the neural plate border R-HSA-9834899 1.573215e-02 1.803 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.651734e-02 1.782 0 0
Membrane Trafficking R-HSA-199991 1.599434e-02 1.796 0 0
HATs acetylate histones R-HSA-3214847 1.671541e-02 1.777 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.673791e-02 1.776 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.695404e-02 1.771 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.695404e-02 1.771 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.695404e-02 1.771 0 0
Calmodulin induced events R-HSA-111933 1.886286e-02 1.724 0 0
CaM pathway R-HSA-111997 1.886286e-02 1.724 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.810617e-02 1.742 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.043166e-02 1.690 0 0
Ca-dependent events R-HSA-111996 2.043166e-02 1.690 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.165480e-02 1.664 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.711696e-02 1.567 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.711696e-02 1.567 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.659942e-02 1.575 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.613446e-02 1.583 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.613446e-02 1.583 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.811874e-02 1.551 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.766240e-02 1.558 1 1
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.750383e-02 1.561 0 0
Disorders of Developmental Biology R-HSA-9675151 2.659942e-02 1.575 0 0
Gene expression (Transcription) R-HSA-74160 2.713419e-02 1.566 0 0
Metabolism of RNA R-HSA-8953854 2.672717e-02 1.573 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.811874e-02 1.551 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.750383e-02 1.561 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.766240e-02 1.558 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.939556e-02 1.532 0 0
Programmed Cell Death R-HSA-5357801 2.986576e-02 1.525 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.997834e-02 1.523 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.023821e-02 1.519 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.181879e-02 1.497 0 0
Signaling by Hippo R-HSA-2028269 3.224644e-02 1.492 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.117865e-02 1.506 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.305445e-02 1.481 0 0
Apoptosis R-HSA-109581 3.350807e-02 1.475 0 0
Nuclear import of Rev protein R-HSA-180746 3.420013e-02 1.466 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.708839e-02 1.431 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.668820e-02 1.435 0 0
Centrosome maturation R-HSA-380287 3.610862e-02 1.442 0 0
Interleukin-6 signaling R-HSA-1059683 3.708839e-02 1.431 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.708839e-02 1.431 0 0
G2/M Transition R-HSA-69275 3.635666e-02 1.439 0 0
Aquaporin-mediated transport R-HSA-445717 3.704550e-02 1.431 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.610862e-02 1.442 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.753491e-02 1.426 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.135375e-02 1.383 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.135375e-02 1.383 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.087161e-02 1.389 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.087161e-02 1.389 0 0
ALK mutants bind TKIs R-HSA-9700645 4.087161e-02 1.389 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.881438e-02 1.411 0 0
GPER1 signaling R-HSA-9634597 4.087294e-02 1.389 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.038232e-02 1.394 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.135375e-02 1.383 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.087294e-02 1.389 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.802798e-02 1.420 0 0
Interleukin-12 signaling R-HSA-9020591 3.933420e-02 1.405 0 0
Activation of the pre-replicative complex R-HSA-68962 4.167741e-02 1.380 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.167741e-02 1.380 0 0
Activation of BH3-only proteins R-HSA-114452 4.167741e-02 1.380 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.416102e-02 1.355 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.525165e-02 1.344 0 0
Rap1 signalling R-HSA-392517 4.574163e-02 1.340 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.574163e-02 1.340 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.747358e-02 1.324 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.747358e-02 1.324 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.089665e-02 1.293 0 0
TGFBR3 expression R-HSA-9839394 5.089665e-02 1.293 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.890158e-02 1.311 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.165890e-02 1.287 0 0
2-LTR circle formation R-HSA-164843 5.192316e-02 1.285 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.430202e-02 1.265 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.824647e-02 1.235 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.377091e-02 1.269 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.611903e-02 1.251 0 0
Myogenesis R-HSA-525793 5.824647e-02 1.235 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.514613e-02 1.258 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.514613e-02 1.258 0 0
Protein methylation R-HSA-8876725 5.469376e-02 1.262 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.944883e-02 1.226 1 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.447678e-02 1.264 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.513471e-02 1.259 0 0
Cellular responses to stimuli R-HSA-8953897 5.547512e-02 1.256 0 0
Interleukin-12 family signaling R-HSA-447115 5.641429e-02 1.249 0 0
Gastrulation R-HSA-9758941 6.048673e-02 1.218 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.057871e-02 1.218 0 0
DAG and IP3 signaling R-HSA-1489509 6.131154e-02 1.212 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.229043e-02 1.206 0 0
Phosphorylation of the APC/C R-HSA-176412 6.502882e-02 1.187 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.502882e-02 1.187 0 0
Prolonged ERK activation events R-HSA-169893 6.502882e-02 1.187 1 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.502882e-02 1.187 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.554232e-02 1.183 0 0
MHC class II antigen presentation R-HSA-2132295 6.617964e-02 1.179 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.010296e-01 0.996 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.010296e-01 0.996 0 0
KIT mutants bind TKIs R-HSA-9669921 1.010296e-01 0.996 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.010296e-01 0.996 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.010296e-01 0.996 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.010296e-01 0.996 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.010296e-01 0.996 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.010296e-01 0.996 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.010296e-01 0.996 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.010296e-01 0.996 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.010296e-01 0.996 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.010296e-01 0.996 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.010296e-01 0.996 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.010296e-01 0.996 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.010296e-01 0.996 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.010296e-01 0.996 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.863836e-02 1.163 0 0
CASP5 inflammasome assembly R-HSA-9948011 1.918576e-01 0.717 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 1.918576e-01 0.717 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.918576e-01 0.717 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.918576e-01 0.717 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.918576e-01 0.717 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.918576e-01 0.717 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 1.918576e-01 0.717 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.918576e-01 0.717 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 1.918576e-01 0.717 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.918576e-01 0.717 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.918576e-01 0.717 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.918576e-01 0.717 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.918576e-01 0.717 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.001954e-01 0.999 0 0
MET interacts with TNS proteins R-HSA-8875513 1.001954e-01 0.999 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.001954e-01 0.999 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.278017e-02 1.138 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.348842e-01 0.870 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.348842e-01 0.870 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.735136e-01 0.563 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.735136e-01 0.563 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 2.735136e-01 0.563 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 2.735136e-01 0.563 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.735136e-01 0.563 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.735136e-01 0.563 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.735136e-01 0.563 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.735136e-01 0.563 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.735136e-01 0.563 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.735136e-01 0.563 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.735136e-01 0.563 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 9.258442e-02 1.033 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.258442e-02 1.033 1 1
G2 Phase R-HSA-68911 1.717506e-01 0.765 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.717506e-01 0.765 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.717506e-01 0.765 0 0
Type I hemidesmosome assembly R-HSA-446107 1.143361e-01 0.942 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.143361e-01 0.942 1 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.143361e-01 0.942 1 1
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.838330e-02 1.106 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.838330e-02 1.106 0 0
Repression of WNT target genes R-HSA-4641265 9.369656e-02 1.028 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 9.369656e-02 1.028 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.377954e-01 0.861 0 0
WNT mediated activation of DVL R-HSA-201688 1.377954e-01 0.861 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.377954e-01 0.861 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.100012e-01 0.678 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 2.100012e-01 0.678 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.100012e-01 0.678 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.100012e-01 0.678 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.100012e-01 0.678 1 1
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.100012e-01 0.678 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.100012e-01 0.678 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.100012e-01 0.678 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 3.469232e-01 0.460 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.469232e-01 0.460 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.469232e-01 0.460 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.469232e-01 0.460 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.469232e-01 0.460 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.469232e-01 0.460 0 0
Defective DHDDS causes RP59 R-HSA-4755609 3.469232e-01 0.460 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.637889e-02 1.117 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.627152e-01 0.789 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.627152e-01 0.789 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.872546e-02 1.052 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.281200e-01 0.892 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.489806e-01 0.604 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.489806e-01 0.604 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.489806e-01 0.604 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.020402e-01 0.991 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.194444e-02 1.086 0 0
DCC mediated attractive signaling R-HSA-418885 1.470431e-01 0.833 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.470431e-01 0.833 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.470431e-01 0.833 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.162858e-01 0.934 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.292417e-02 1.032 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.314174e-01 0.881 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.881513e-01 0.540 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.881513e-01 0.540 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 2.881513e-01 0.540 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.881513e-01 0.540 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.881513e-01 0.540 0 0
SOS-mediated signalling R-HSA-112412 2.881513e-01 0.540 0 0
Recycling of eIF2:GDP R-HSA-72731 2.881513e-01 0.540 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.881513e-01 0.540 0 0
Disinhibition of SNARE formation R-HSA-114516 2.881513e-01 0.540 0 0
FasL/ CD95L signaling R-HSA-75157 4.129188e-01 0.384 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.129188e-01 0.384 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.129188e-01 0.384 0 0
Axonal growth stimulation R-HSA-209563 4.129188e-01 0.384 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.129188e-01 0.384 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.129188e-01 0.384 0 0
Classical Kir channels R-HSA-1296053 4.129188e-01 0.384 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.129188e-01 0.384 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.129188e-01 0.384 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.129188e-01 0.384 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.877804e-01 0.726 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.043346e-01 0.982 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.438022e-01 0.613 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.298868e-02 1.081 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.298868e-02 1.081 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.270772e-01 0.485 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.270772e-01 0.485 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.111783e-02 1.091 0 0
Notch-HLH transcription pathway R-HSA-350054 1.815821e-01 0.741 0 0
FGFR3 mutant receptor activation R-HSA-2033514 2.721740e-01 0.565 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 2.721740e-01 0.565 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.721740e-01 0.565 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.316113e-01 0.635 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.316113e-01 0.635 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.996878e-01 0.700 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.277990e-01 0.893 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.183741e-01 0.661 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.008677e-01 0.522 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.008677e-01 0.522 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.008677e-01 0.522 0 0
ARMS-mediated activation R-HSA-170984 3.654080e-01 0.437 1 1
AKT phosphorylates targets in the nucleus R-HSA-198693 3.654080e-01 0.437 0 0
CASP8 activity is inhibited R-HSA-5218900 3.654080e-01 0.437 0 0
Regulation of gap junction activity R-HSA-191650 4.722489e-01 0.326 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.722489e-01 0.326 0 0
Nucleotide catabolism defects R-HSA-9735786 4.722489e-01 0.326 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 4.722489e-01 0.326 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.722489e-01 0.326 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.722489e-01 0.326 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.722489e-01 0.326 0 0
snRNP Assembly R-HSA-191859 1.079786e-01 0.967 0 0
Metabolism of non-coding RNA R-HSA-194441 1.079786e-01 0.967 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.030399e-01 0.987 0 0
Trafficking of AMPA receptors R-HSA-399719 2.054638e-01 0.687 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.776111e-01 0.557 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.776111e-01 0.557 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.409033e-01 0.851 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.296975e-01 0.482 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.296975e-01 0.482 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.296975e-01 0.482 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.296975e-01 0.482 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.509406e-01 0.821 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.572076e-01 0.590 0 0
G-protein beta:gamma signalling R-HSA-397795 2.391429e-01 0.621 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.391429e-01 0.621 0 0
CASP4 inflammasome assembly R-HSA-9948001 4.028668e-01 0.395 0 0
PI3K/AKT activation R-HSA-198203 4.028668e-01 0.395 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.028668e-01 0.395 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.028668e-01 0.395 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.772131e-01 0.557 0 0
Orc1 removal from chromatin R-HSA-68949 1.951918e-01 0.710 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.584948e-01 0.446 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.248874e-01 0.488 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.248874e-01 0.488 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.248874e-01 0.488 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.076859e-01 0.683 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.392384e-01 0.357 0 0
Signaling by APC mutants R-HSA-4839744 4.392384e-01 0.357 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.392384e-01 0.357 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.392384e-01 0.357 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.392384e-01 0.357 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.255862e-01 0.279 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.255862e-01 0.279 0 0
IRS activation R-HSA-74713 5.255862e-01 0.279 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.255862e-01 0.279 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.255862e-01 0.279 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.255862e-01 0.279 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.255862e-01 0.279 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.255862e-01 0.279 0 0
Defective F9 activation R-HSA-9673221 5.255862e-01 0.279 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.469701e-01 0.607 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.865665e-01 0.543 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.744523e-01 0.562 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.290687e-01 0.483 1 1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.110809e-01 0.507 0 0
Deadenylation of mRNA R-HSA-429947 3.964201e-01 0.402 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.743603e-01 0.324 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.743603e-01 0.324 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.743603e-01 0.324 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.367243e-01 0.473 0 0
Nucleosome assembly R-HSA-774815 3.367243e-01 0.473 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.266074e-01 0.486 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.663131e-01 0.436 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.432635e-01 0.353 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 4.432635e-01 0.353 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.432635e-01 0.353 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.537216e-01 0.451 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.537216e-01 0.451 1 1
Signaling downstream of RAS mutants R-HSA-9649948 3.537216e-01 0.451 1 1
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.537216e-01 0.451 0 0
Translation initiation complex formation R-HSA-72649 3.422640e-01 0.466 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.200703e-01 0.377 0 0
G protein gated Potassium channels R-HSA-1296059 4.200703e-01 0.377 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.200703e-01 0.377 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.707989e-01 0.431 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.218975e-01 0.375 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.081136e-01 0.294 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.081136e-01 0.294 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.081136e-01 0.294 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.081136e-01 0.294 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.081136e-01 0.294 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.081136e-01 0.294 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.081136e-01 0.294 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.081136e-01 0.294 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.081136e-01 0.294 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.735358e-01 0.241 0 0
TRAIL signaling R-HSA-75158 5.735358e-01 0.241 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.735358e-01 0.241 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.735358e-01 0.241 0 0
Defective MTRR causes HMAE R-HSA-3359467 5.735358e-01 0.241 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.735358e-01 0.241 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.735358e-01 0.241 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.149614e-01 0.502 0 0
MAP2K and MAPK activation R-HSA-5674135 4.223936e-01 0.374 1 1
Signaling by RAF1 mutants R-HSA-9656223 4.223936e-01 0.374 1 1
Dual Incision in GG-NER R-HSA-5696400 4.424882e-01 0.354 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.666201e-01 0.331 0 0
Activation of GABAB receptors R-HSA-991365 4.409765e-01 0.356 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.206223e-01 0.376 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.404163e-01 0.267 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.404163e-01 0.267 0 0
Formation of axial mesoderm R-HSA-9796292 5.404163e-01 0.267 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.404163e-01 0.267 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.404163e-01 0.267 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.027179e-01 0.395 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.232854e-01 0.281 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.232854e-01 0.281 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.730917e-01 0.325 0 0
Late endosomal microautophagy R-HSA-9615710 5.117496e-01 0.291 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.524197e-01 0.344 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.485299e-01 0.261 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.485299e-01 0.261 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.485299e-01 0.261 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.485299e-01 0.261 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.712168e-01 0.243 0 0
Removal of the Flap Intermediate R-HSA-69166 5.712168e-01 0.243 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.712168e-01 0.243 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.712168e-01 0.243 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.714277e-01 0.327 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.418549e-01 0.266 0 0
EGFR downregulation R-HSA-182971 5.550483e-01 0.256 0 0
Signaling by KIT in disease R-HSA-9669938 5.729696e-01 0.242 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.729696e-01 0.242 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.729696e-01 0.242 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.607445e-01 0.251 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.004888e-01 0.221 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.004888e-01 0.221 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.004888e-01 0.221 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.004888e-01 0.221 0 0
Protein lipoylation R-HSA-9857492 6.004888e-01 0.221 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.004888e-01 0.221 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.792344e-01 0.237 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.962058e-01 0.225 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.818501e-01 0.550 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.099926e-01 0.959 0 0
Protein folding R-HSA-391251 2.055882e-01 0.687 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.117496e-01 0.291 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.387472e-01 0.470 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.149614e-01 0.502 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.517782e-01 0.819 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.572076e-01 0.590 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.050569e-01 0.392 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.225928e-01 0.282 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.541855e-01 0.595 0 0
Signaling by SCF-KIT R-HSA-1433557 3.031107e-01 0.518 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.336495e-01 0.273 0 0
Gap junction trafficking and regulation R-HSA-157858 2.655674e-01 0.576 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.165774e-01 0.664 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.799489e-02 1.108 1 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.503472e-01 0.346 0 0
Gap junction trafficking R-HSA-190828 1.949470e-01 0.710 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.168706e-01 0.287 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.154166e-01 0.288 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.869455e-01 0.231 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.743603e-01 0.324 0 0
GABA B receptor activation R-HSA-977444 4.409765e-01 0.356 0 0
IGF1R signaling cascade R-HSA-2428924 5.000555e-01 0.301 0 0
ESR-mediated signaling R-HSA-8939211 1.610022e-01 0.793 0 0
Gap junction assembly R-HSA-190861 7.574970e-02 1.121 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.384575e-01 0.623 0 0
Aggrephagy R-HSA-9646399 1.336508e-01 0.874 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.958692e-01 0.305 0 0
Integration of provirus R-HSA-162592 7.838330e-02 1.106 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.314174e-01 0.881 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.772131e-01 0.557 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.356556e-01 0.474 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.705859e-01 0.327 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.004888e-01 0.221 0 0
Homology Directed Repair R-HSA-5693538 2.484460e-01 0.605 0 0
DNA Double Strand Break Response R-HSA-5693606 1.824241e-01 0.739 0 0
Frs2-mediated activation R-HSA-170968 1.103049e-01 0.957 1 1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.831099e-01 0.737 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.129313e-01 0.505 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.702460e-01 0.568 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.964201e-01 0.402 0 0
PCP/CE pathway R-HSA-4086400 3.127713e-01 0.505 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.531973e-01 0.344 0 0
G-protein activation R-HSA-202040 5.232854e-01 0.281 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.680206e-01 0.434 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.267553e-01 0.644 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.267553e-01 0.644 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.666201e-01 0.331 0 0
Nucleotide Excision Repair R-HSA-5696398 5.905423e-01 0.229 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.100012e-01 0.678 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.872546e-02 1.052 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.669672e-01 0.777 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.171137e-01 0.931 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.171137e-01 0.931 0 0
Interleukin-1 processing R-HSA-448706 3.654080e-01 0.437 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.654080e-01 0.437 0 0
Regulation of CDH11 function R-HSA-9762292 4.028668e-01 0.395 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.392384e-01 0.357 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.729696e-01 0.242 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.729696e-01 0.242 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.468833e-01 0.262 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.759105e-01 0.240 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.706415e-01 0.244 0 0
Signaling by FGFR3 R-HSA-5654741 4.958692e-01 0.305 1 0
Chromosome Maintenance R-HSA-73886 5.755902e-01 0.240 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.304947e-01 0.637 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.076300e-01 0.512 0 0
Signaling by RAS mutants R-HSA-6802949 3.537216e-01 0.451 1 0
Regulation of TP53 Degradation R-HSA-6804757 4.830776e-01 0.316 0 0
Cellular response to heat stress R-HSA-3371556 9.208460e-02 1.036 0 0
G1/S Transition R-HSA-69206 2.428180e-01 0.615 0 0
Activation of RAC1 R-HSA-428540 7.838330e-02 1.106 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.369656e-02 1.028 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.100012e-01 0.678 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.637889e-02 1.117 0 0
Sodium/Proton exchangers R-HSA-425986 3.270772e-01 0.485 0 0
Regulation by c-FLIP R-HSA-3371378 3.270772e-01 0.485 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.996878e-01 0.700 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.654080e-01 0.437 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.106240e-01 0.508 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.081136e-01 0.294 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.404163e-01 0.267 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.232854e-01 0.281 0 0
Regulation of CDH1 Function R-HSA-9764561 5.389781e-01 0.268 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.990943e-01 0.223 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.923605e-01 0.534 0 0
Nuclear RNA decay R-HSA-9930044 1.270307e-01 0.896 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.503801e-01 0.601 0 0
DNA Replication R-HSA-69306 4.576781e-01 0.339 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.818501e-01 0.550 0 0
Signalling to ERKs R-HSA-187687 8.411808e-02 1.075 1 0
Vasopressin-like receptors R-HSA-388479 1.348842e-01 0.870 0 0
Signal attenuation R-HSA-74749 4.028668e-01 0.395 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.081136e-01 0.294 0 0
HSF1 activation R-HSA-3371511 4.830776e-01 0.316 0 0
Degradation of DVL R-HSA-4641258 5.029890e-01 0.298 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.336495e-01 0.273 0 0
Interleukin-6 family signaling R-HSA-6783589 2.183741e-01 0.661 0 0
Mitotic Prophase R-HSA-68875 1.320455e-01 0.879 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.229890e-01 0.652 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.434929e-01 0.353 0 0
Signaling by WNT R-HSA-195721 1.263133e-01 0.899 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.208712e-01 0.656 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.485299e-01 0.261 0 0
Signaling by WNT in cancer R-HSA-4791275 5.759105e-01 0.240 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.908398e-01 0.719 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.717506e-01 0.765 0 0
Calcineurin activates NFAT R-HSA-2025928 1.377954e-01 0.861 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.637889e-02 1.117 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.020402e-01 0.991 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.020402e-01 0.991 0 0
PTK6 Expression R-HSA-8849473 2.881513e-01 0.540 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.387963e-02 1.027 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.093672e-01 0.679 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.270772e-01 0.485 0 0
Dimerization of procaspase-8 R-HSA-69416 3.270772e-01 0.485 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.270307e-01 0.896 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.028668e-01 0.395 0 0
Killing mechanisms R-HSA-9664420 3.584948e-01 0.446 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.584948e-01 0.446 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.975173e-01 0.526 0 0
RAF activation R-HSA-5673000 2.743265e-01 0.562 1 1
Synthesis of DNA R-HSA-69239 1.411321e-01 0.850 0 0
Intraflagellar transport R-HSA-5620924 2.508462e-01 0.601 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.392384e-01 0.357 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.255862e-01 0.279 0 0
PTK6 Down-Regulation R-HSA-8849472 5.255862e-01 0.279 0 0
Activation of AKT2 R-HSA-165158 5.255862e-01 0.279 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.865665e-01 0.543 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.743603e-01 0.324 0 0
Integrin signaling R-HSA-354192 4.011736e-01 0.397 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.434929e-01 0.353 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.328152e-01 0.273 0 0
FGFR3 ligand binding and activation R-HSA-190239 6.004888e-01 0.221 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.418549e-01 0.266 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.384575e-01 0.623 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.280184e-01 0.369 0 0
DNA Repair R-HSA-73894 4.880370e-01 0.312 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.384212e-01 0.623 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.773907e-01 0.423 0 0
Recycling pathway of L1 R-HSA-437239 3.707989e-01 0.431 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 5.404163e-01 0.267 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.543971e-01 0.594 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.367243e-01 0.473 0 0
Ca2+ pathway R-HSA-4086398 4.944565e-01 0.306 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.714845e-01 0.243 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.669672e-01 0.777 0 0
mTORC1-mediated signalling R-HSA-166208 1.815821e-01 0.741 0 0
G2/M Checkpoints R-HSA-69481 2.609534e-01 0.583 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.562183e-01 0.341 0 0
PTEN Regulation R-HSA-6807070 4.950454e-01 0.305 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.921644e-01 0.308 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.004888e-01 0.221 0 0
Cellular Senescence R-HSA-2559583 2.296517e-01 0.639 0 0
NGF-stimulated transcription R-HSA-9031628 1.487164e-01 0.828 0 0
MTOR signalling R-HSA-165159 9.106803e-02 1.041 0 0
Interleukin-9 signaling R-HSA-8985947 3.270772e-01 0.485 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.375709e-01 0.624 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.661630e-01 0.575 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.881513e-01 0.540 0 0
Disorders of Nervous System Development R-HSA-9697154 2.438022e-01 0.613 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.438022e-01 0.613 0 0
Pervasive developmental disorders R-HSA-9005895 2.438022e-01 0.613 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.722489e-01 0.326 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.722489e-01 0.326 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.028668e-01 0.395 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.392384e-01 0.357 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.255862e-01 0.279 0 0
Activation of C3 and C5 R-HSA-174577 5.255862e-01 0.279 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.154037e-01 0.382 0 0
DNA strand elongation R-HSA-69190 3.803693e-01 0.420 0 0
Stabilization of p53 R-HSA-69541 3.663131e-01 0.436 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.705859e-01 0.327 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.735358e-01 0.241 0 0
Degradation of CDH1 R-HSA-9766229 4.050569e-01 0.392 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.666201e-01 0.331 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.524428e-01 0.344 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.798421e-01 0.319 0 0
Mismatch Repair R-HSA-5358508 4.432635e-01 0.353 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.996878e-01 0.700 0 0
Negative regulation of MET activity R-HSA-6807004 2.776111e-01 0.557 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.487438e-01 0.457 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.089585e-01 0.293 0 0
Signaling by VEGF R-HSA-194138 1.188668e-01 0.925 0 0
Signaling by EGFR R-HSA-177929 5.227951e-01 0.282 0 0
Oncogene Induced Senescence R-HSA-2559585 1.652626e-01 0.782 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.434929e-01 0.353 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.198420e-01 0.495 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.281200e-01 0.892 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.975173e-01 0.526 1 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.964201e-01 0.402 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.317179e-01 0.479 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.037287e-01 0.394 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.759105e-01 0.240 0 0
Hedgehog 'on' state R-HSA-5632684 3.356556e-01 0.474 0 0
Circadian clock R-HSA-9909396 7.851980e-02 1.105 0 0
HIV Life Cycle R-HSA-162587 9.031404e-02 1.044 0 0
Autophagy R-HSA-9612973 3.121600e-01 0.506 0 0
S Phase R-HSA-69242 1.264436e-01 0.898 0 0
Protein ubiquitination R-HSA-8852135 5.233318e-01 0.281 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.074837e-01 0.683 0 0
Opioid Signalling R-HSA-111885 1.145047e-01 0.941 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.263551e-01 0.645 1 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.180989e-01 0.661 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.154037e-01 0.382 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.705859e-01 0.327 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.336495e-01 0.273 0 0
Signaling by NTRKs R-HSA-166520 8.658820e-02 1.063 1 0
RNA Polymerase II Transcription R-HSA-73857 1.083204e-01 0.965 0 0
Vesicle-mediated transport R-HSA-5653656 2.808456e-01 0.552 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.223463e-02 1.141 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.426340e-01 0.846 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.093672e-01 0.679 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.270307e-01 0.896 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.050569e-01 0.392 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.050569e-01 0.392 0 0
Cilium Assembly R-HSA-5617833 1.808182e-01 0.743 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.438177e-01 0.842 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.110824e-01 0.507 0 0
Semaphorin interactions R-HSA-373755 8.244281e-02 1.084 0 0
G-protein mediated events R-HSA-112040 1.824241e-01 0.739 0 0
Generic Transcription Pathway R-HSA-212436 4.320943e-01 0.364 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.736692e-01 0.760 0 0
Signaling by FGFR in disease R-HSA-1226099 2.625084e-01 0.581 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.450309e-01 0.839 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.649301e-01 0.783 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.944782e-01 0.711 0 0
HIV Infection R-HSA-162906 1.141393e-01 0.943 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.355304e-01 0.868 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.438380e-01 0.265 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.384575e-01 0.623 0 0
FLT3 signaling in disease R-HSA-9682385 3.106240e-01 0.508 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.303202e-01 0.638 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.001954e-01 0.999 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.735136e-01 0.563 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.735136e-01 0.563 0 0
Unwinding of DNA R-HSA-176974 1.377954e-01 0.861 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.100012e-01 0.678 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.469232e-01 0.460 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.469232e-01 0.460 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.020402e-01 0.991 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.020402e-01 0.991 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.129188e-01 0.384 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.129188e-01 0.384 0 0
The IPAF inflammasome R-HSA-844623 4.129188e-01 0.384 0 0
Regulation of IFNG signaling R-HSA-877312 2.438022e-01 0.613 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.721740e-01 0.565 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.519900e-01 0.818 0 0
The NLRP3 inflammasome R-HSA-844456 2.543971e-01 0.594 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.543971e-01 0.594 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.008677e-01 0.522 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.722489e-01 0.326 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.722489e-01 0.326 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.380530e-01 0.860 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.932595e-01 0.714 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.084210e-01 0.681 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.975173e-01 0.526 0 0
Intra-Golgi traffic R-HSA-6811438 2.702460e-01 0.568 0 0
Platelet calcium homeostasis R-HSA-418360 3.180510e-01 0.498 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.392384e-01 0.357 0 0
Signaling by AXIN mutants R-HSA-4839735 4.743603e-01 0.324 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.743603e-01 0.324 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.432635e-01 0.353 0 0
Interleukin-7 signaling R-HSA-1266695 4.200703e-01 0.377 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.317179e-01 0.479 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.081136e-01 0.294 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.735358e-01 0.241 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.735358e-01 0.241 0 0
PKB-mediated events R-HSA-109703 5.735358e-01 0.241 0 0
PDE3B signalling R-HSA-165160 5.735358e-01 0.241 0 0
Phosphorylation of Emi1 R-HSA-176417 5.735358e-01 0.241 0 0
Reproduction R-HSA-1474165 2.986508e-01 0.525 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.404163e-01 0.267 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.404163e-01 0.267 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.898290e-01 0.310 0 0
Cellular response to hypoxia R-HSA-1234174 5.154166e-01 0.288 0 0
Budding and maturation of HIV virion R-HSA-162588 5.550483e-01 0.256 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.495888e-01 0.260 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.004888e-01 0.221 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.869455e-01 0.231 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.702460e-01 0.568 0 0
Rab regulation of trafficking R-HSA-9007101 3.254518e-01 0.488 0 0
Macroautophagy R-HSA-1632852 4.192706e-01 0.378 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.712168e-01 0.243 0 0
Selective autophagy R-HSA-9663891 3.411505e-01 0.467 0 0
EPH-Ephrin signaling R-HSA-2682334 4.043538e-01 0.393 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.537216e-01 0.451 0 0
Host Interactions of HIV factors R-HSA-162909 1.076399e-01 0.968 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.473830e-01 0.832 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.450309e-01 0.839 0 0
MAPK family signaling cascades R-HSA-5683057 5.275831e-01 0.278 1 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.975173e-01 0.526 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.962058e-01 0.225 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.367243e-01 0.473 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.367243e-01 0.473 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.004888e-01 0.221 1 1
Regulation of TP53 Activity R-HSA-5633007 2.702812e-01 0.568 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.556941e-02 1.068 0 0
TNF signaling R-HSA-75893 2.469701e-01 0.607 0 0
Regulation of insulin secretion R-HSA-422356 2.774353e-01 0.557 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.438022e-01 0.613 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.654080e-01 0.437 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.391429e-01 0.621 0 0
Integration of energy metabolism R-HSA-163685 1.013218e-01 0.994 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.043671e-01 0.393 0 0
Heme signaling R-HSA-9707616 4.689251e-01 0.329 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.698206e-01 0.244 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.698206e-01 0.244 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.463798e-01 0.460 0 0
Signaling by PTK6 R-HSA-8848021 3.463798e-01 0.460 0 0
Cell junction organization R-HSA-446728 5.769534e-01 0.239 0 0
Growth hormone receptor signaling R-HSA-982772 1.996878e-01 0.700 0 0
tRNA processing in the nucleus R-HSA-6784531 1.334710e-01 0.875 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.255862e-01 0.279 0 0
TBC/RABGAPs R-HSA-8854214 3.031107e-01 0.518 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.580226e-01 0.446 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.029890e-01 0.298 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.336495e-01 0.273 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.799489e-02 1.108 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.357741e-02 1.029 0 0
Axon guidance R-HSA-422475 2.852220e-01 0.545 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.531973e-01 0.344 0 0
Other interleukin signaling R-HSA-449836 1.162858e-01 0.934 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.973008e-01 0.224 1 1
Nervous system development R-HSA-9675108 1.764289e-01 0.753 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.220911e-01 0.653 0 0
PLC beta mediated events R-HSA-112043 1.246370e-01 0.904 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.143361e-01 0.942 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.100012e-01 0.678 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.790366e-02 1.168 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.881513e-01 0.540 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.815821e-01 0.741 0 0
Signal regulatory protein family interactions R-HSA-391160 3.008677e-01 0.522 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.722489e-01 0.326 0 0
Interleukin-27 signaling R-HSA-9020956 4.028668e-01 0.395 0 0
Polo-like kinase mediated events R-HSA-156711 4.432635e-01 0.353 0 0
Signaling by LTK R-HSA-9842663 5.081136e-01 0.294 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.404163e-01 0.267 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.990943e-01 0.223 0 0
Inflammasomes R-HSA-622312 4.893905e-01 0.310 0 0
Signaling by MET R-HSA-6806834 5.927488e-01 0.227 0 0
Cellular responses to stress R-HSA-2262752 1.435889e-01 0.843 0 0
Interleukin-35 Signalling R-HSA-8984722 5.081136e-01 0.294 0 0
Signaling by ROBO receptors R-HSA-376176 8.203002e-02 1.086 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.761024e-01 0.754 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.860858e-01 0.232 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 9.258442e-02 1.033 0 0
RUNX2 regulates bone development R-HSA-8941326 3.106240e-01 0.508 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.200703e-01 0.377 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.081136e-01 0.294 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.081136e-01 0.294 0 0
Glucagon-type ligand receptors R-HSA-420092 5.117496e-01 0.291 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.237361e-01 0.373 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.581296e-02 1.120 0 0
Signaling by Leptin R-HSA-2586552 4.028668e-01 0.395 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.304947e-01 0.637 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.046541e-01 0.980 0 0
Signaling by TGFB family members R-HSA-9006936 1.036434e-01 0.984 0 0
Maturation of nucleoprotein R-HSA-9694631 1.162858e-01 0.934 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.270307e-01 0.896 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.503472e-01 0.346 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.962058e-01 0.225 0 0
Interleukin-15 signaling R-HSA-8983432 5.081136e-01 0.294 0 0
L1CAM interactions R-HSA-373760 3.149614e-01 0.502 0 0
Diseases of programmed cell death R-HSA-9645723 5.831850e-01 0.234 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.965676e-01 0.224 0 0
Signaling by ERBB2 R-HSA-1227986 5.860858e-01 0.232 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.066698e-01 0.685 0 0
DSCAM interactions R-HSA-376172 3.469232e-01 0.460 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.489806e-01 0.604 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.129188e-01 0.384 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.721740e-01 0.565 0 0
Maturation of nucleoprotein R-HSA-9683610 2.721740e-01 0.565 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.392379e-01 0.856 0 0
NADE modulates death signalling R-HSA-205025 4.722489e-01 0.326 0 0
Post NMDA receptor activation events R-HSA-438064 9.501742e-02 1.022 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.110809e-01 0.507 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.743603e-01 0.324 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.578313e-01 0.589 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.735358e-01 0.241 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.531973e-01 0.344 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.232854e-01 0.281 0 0
G0 and Early G1 R-HSA-1538133 5.759105e-01 0.240 0 0
Other semaphorin interactions R-HSA-416700 6.004888e-01 0.221 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.755718e-01 0.323 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.897349e-01 0.409 0 0
Formation of definitive endoderm R-HSA-9823730 4.972842e-01 0.303 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.317230e-01 0.365 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.702460e-01 0.568 0 0
Signaling by TGFBR3 R-HSA-9839373 3.537216e-01 0.451 0 0
FLT3 Signaling R-HSA-9607240 1.450309e-01 0.839 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.143361e-01 0.942 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.377954e-01 0.861 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.470431e-01 0.833 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.387472e-01 0.470 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.503472e-01 0.346 0 0
Interferon Signaling R-HSA-913531 5.226998e-01 0.282 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.028668e-01 0.395 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.011736e-01 0.397 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.558607e-01 0.449 0 0
Signal transduction by L1 R-HSA-445144 4.972842e-01 0.303 0 0
Interleukin-1 family signaling R-HSA-446652 5.417266e-01 0.266 0 0
Syndecan interactions R-HSA-3000170 3.726174e-01 0.429 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.738554e-01 0.427 0 0
NrCAM interactions R-HSA-447038 1.717506e-01 0.765 0 0
The AIM2 inflammasome R-HSA-844615 3.469232e-01 0.460 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.881513e-01 0.540 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.093672e-01 0.679 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.450309e-01 0.839 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.654080e-01 0.437 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.722489e-01 0.326 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.722489e-01 0.326 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.028668e-01 0.395 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.584948e-01 0.446 0 0
Pyroptosis R-HSA-5620971 2.975173e-01 0.526 0 0
Co-inhibition by BTLA R-HSA-9927353 5.255862e-01 0.279 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.255862e-01 0.279 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.743603e-01 0.324 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.432635e-01 0.353 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.404163e-01 0.267 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.485299e-01 0.261 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.924805e-01 0.716 0 0
Signaling by ALK R-HSA-201556 2.229890e-01 0.652 0 0
Triglyceride catabolism R-HSA-163560 4.830776e-01 0.316 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.867629e-01 0.729 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.302772e-01 0.885 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.485089e-01 0.458 0 0
Biotin transport and metabolism R-HSA-196780 6.004888e-01 0.221 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.110809e-01 0.507 0 0
Glycolysis R-HSA-70171 4.035822e-01 0.394 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.654080e-01 0.437 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.729696e-01 0.242 0 0
RET signaling R-HSA-8853659 1.790288e-01 0.747 0 0
Regulated Necrosis R-HSA-5218859 5.604583e-01 0.251 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.470431e-01 0.833 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.881513e-01 0.540 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.270772e-01 0.485 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.222461e-01 0.653 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.255862e-01 0.279 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.255862e-01 0.279 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.735358e-01 0.241 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.712168e-01 0.243 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.755902e-01 0.240 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.316113e-01 0.635 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.004888e-01 0.221 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.392384e-01 0.357 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.424882e-01 0.354 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.404163e-01 0.267 0 0
Physiological factors R-HSA-5578768 5.712168e-01 0.243 0 0
PKR-mediated signaling R-HSA-9833482 4.616371e-01 0.336 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.743603e-01 0.324 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.852122e-02 1.105 0 0
Formation of the anterior neural plate R-HSA-9823739 6.004888e-01 0.221 0 0
HDL assembly R-HSA-8963896 3.008677e-01 0.522 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.036001e-01 0.219 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.110671e-01 0.214 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.149234e-01 0.211 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.151716e-01 0.211 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.159097e-01 0.210 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.159097e-01 0.210 0 0
Signaling by LTK in cancer R-HSA-9842640 6.166416e-01 0.210 0 0
STAT5 Activation R-HSA-9645135 6.166416e-01 0.210 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.166416e-01 0.210 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.166416e-01 0.210 0 0
Defective MTR causes HMAG R-HSA-3359469 6.166416e-01 0.210 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.166416e-01 0.210 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.166416e-01 0.210 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.166416e-01 0.210 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.166416e-01 0.210 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.166416e-01 0.210 0 0
Abacavir transmembrane transport R-HSA-2161517 6.166416e-01 0.210 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.166416e-01 0.210 0 0
CREB phosphorylation R-HSA-199920 6.166416e-01 0.210 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.166416e-01 0.210 0 0
Metabolism of vitamin K R-HSA-6806664 6.166416e-01 0.210 0 0
Nef and signal transduction R-HSA-164944 6.166416e-01 0.210 0 0
HDL clearance R-HSA-8964011 6.166416e-01 0.210 0 0
Neurofascin interactions R-HSA-447043 6.166416e-01 0.210 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.174946e-01 0.209 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.192966e-01 0.208 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.192966e-01 0.208 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.192966e-01 0.208 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.209460e-01 0.207 0 0
Transmission across Chemical Synapses R-HSA-112315 6.238600e-01 0.205 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.248609e-01 0.204 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.282266e-01 0.202 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.282266e-01 0.202 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.282266e-01 0.202 0 0
Activation of SMO R-HSA-5635838 6.282266e-01 0.202 0 0
Regulation of BACH1 activity R-HSA-9708530 6.282266e-01 0.202 0 0
Negative regulation of FLT3 R-HSA-9706369 6.282266e-01 0.202 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.282266e-01 0.202 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.282266e-01 0.202 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.282266e-01 0.202 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.306856e-01 0.200 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.308804e-01 0.200 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.320850e-01 0.199 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.331097e-01 0.199 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.350025e-01 0.197 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.350025e-01 0.197 0 0
Signal amplification R-HSA-392518 6.350025e-01 0.197 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.350025e-01 0.197 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.350025e-01 0.197 0 0
Co-inhibition by PD-1 R-HSA-389948 6.371493e-01 0.196 0 0
Glucose metabolism R-HSA-70326 6.375669e-01 0.195 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.411382e-01 0.193 0 0
Long-term potentiation R-HSA-9620244 6.411382e-01 0.193 0 0
HDMs demethylate histones R-HSA-3214842 6.411382e-01 0.193 0 0
Cell-Cell communication R-HSA-1500931 6.415882e-01 0.193 0 0
Signaling by ERBB4 R-HSA-1236394 6.444883e-01 0.191 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.446061e-01 0.191 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.449328e-01 0.190 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.451182e-01 0.190 0 0
Netrin-1 signaling R-HSA-373752 6.487711e-01 0.188 0 0
Proteasome assembly R-HSA-9907900 6.487711e-01 0.188 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.534513e-01 0.185 0 0
PERK regulates gene expression R-HSA-381042 6.534692e-01 0.185 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.544413e-01 0.184 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.544413e-01 0.184 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.544413e-01 0.184 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.553927e-01 0.183 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.553927e-01 0.183 0 0
Netrin mediated repulsion signals R-HSA-418886 6.553927e-01 0.183 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.553927e-01 0.183 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 6.553927e-01 0.183 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.553927e-01 0.183 0 0
FGFR3b ligand binding and activation R-HSA-190371 6.553927e-01 0.183 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.553927e-01 0.183 0 0
Reuptake of GABA R-HSA-888593 6.553927e-01 0.183 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.553927e-01 0.183 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.553927e-01 0.183 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.553927e-01 0.183 0 0
Regulation of PTEN localization R-HSA-8948747 6.553927e-01 0.183 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.553927e-01 0.183 0 0
CHL1 interactions R-HSA-447041 6.553927e-01 0.183 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.569784e-01 0.182 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.575694e-01 0.182 0 0
G alpha (z) signalling events R-HSA-418597 6.611441e-01 0.180 0 0
Signaling by NOTCH3 R-HSA-9012852 6.611441e-01 0.180 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.620816e-01 0.179 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.620816e-01 0.179 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.649706e-01 0.177 0 0
Somitogenesis R-HSA-9824272 6.649706e-01 0.177 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.649706e-01 0.177 0 0
Inositol phosphate metabolism R-HSA-1483249 6.682642e-01 0.175 0 0
Signaling by NOTCH1 R-HSA-1980143 6.703631e-01 0.174 0 0
G1/S-Specific Transcription R-HSA-69205 6.712991e-01 0.173 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.712991e-01 0.173 0 0
RNA Polymerase III Transcription R-HSA-74158 6.712991e-01 0.173 0 0
GPVI-mediated activation cascade R-HSA-114604 6.712991e-01 0.173 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.756797e-01 0.170 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.791573e-01 0.168 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.791573e-01 0.168 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.791573e-01 0.168 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.791573e-01 0.168 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.791573e-01 0.168 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.791573e-01 0.168 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.806746e-01 0.167 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.809628e-01 0.167 0 0
Signaling by BMP R-HSA-201451 6.821234e-01 0.166 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.828632e-01 0.166 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.838907e-01 0.165 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.856825e-01 0.164 0 0
Collagen chain trimerization R-HSA-8948216 6.884855e-01 0.162 0 0
IRS-mediated signalling R-HSA-112399 6.898080e-01 0.161 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.902287e-01 0.161 0 0
phospho-PLA2 pathway R-HSA-111995 6.902287e-01 0.161 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.902287e-01 0.161 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.902287e-01 0.161 0 0
Formation of annular gap junctions R-HSA-196025 6.902287e-01 0.161 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.902287e-01 0.161 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.902287e-01 0.161 0 0
Interleukin-23 signaling R-HSA-9020933 6.902287e-01 0.161 0 0
Adrenoceptors R-HSA-390696 6.902287e-01 0.161 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.902287e-01 0.161 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.902287e-01 0.161 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.902287e-01 0.161 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.902287e-01 0.161 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.902287e-01 0.161 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.902287e-01 0.161 0 0
Deubiquitination R-HSA-5688426 6.905509e-01 0.161 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.908096e-01 0.161 0 0
Adipogenesis R-HSA-9843745 6.976337e-01 0.156 0 0
Transcription of the HIV genome R-HSA-167172 6.985793e-01 0.156 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.985793e-01 0.156 0 0
Telomere Extension By Telomerase R-HSA-171319 7.012658e-01 0.154 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.012658e-01 0.154 0 0
Ephrin signaling R-HSA-3928664 7.024097e-01 0.153 0 0
Platelet sensitization by LDL R-HSA-432142 7.024097e-01 0.153 0 0
Nephron development R-HSA-9831926 7.024097e-01 0.153 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.024097e-01 0.153 0 0
Dual incision in TC-NER R-HSA-6782135 7.035238e-01 0.153 0 0
MET promotes cell motility R-HSA-8875878 7.050253e-01 0.152 0 0
Platelet homeostasis R-HSA-418346 7.102025e-01 0.149 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.111247e-01 0.148 0 0
Cellular response to chemical stress R-HSA-9711123 7.116817e-01 0.148 0 0
Extension of Telomeres R-HSA-180786 7.168235e-01 0.145 0 0
Triglyceride metabolism R-HSA-8979227 7.168235e-01 0.145 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.185529e-01 0.144 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.195165e-01 0.143 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.195165e-01 0.143 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.195165e-01 0.143 1 0
Regulation of gene expression in beta cells R-HSA-210745 7.195165e-01 0.143 0 0
Gene Silencing by RNA R-HSA-211000 7.201659e-01 0.143 0 0
Lipophagy R-HSA-9613354 7.215451e-01 0.142 0 0
Gap junction degradation R-HSA-190873 7.215451e-01 0.142 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.215451e-01 0.142 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.215451e-01 0.142 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.215451e-01 0.142 0 0
Interleukin-21 signaling R-HSA-9020958 7.215451e-01 0.142 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.215451e-01 0.142 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.215451e-01 0.142 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.215451e-01 0.142 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.215451e-01 0.142 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.215451e-01 0.142 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.215451e-01 0.142 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.215451e-01 0.142 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.215451e-01 0.142 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.215451e-01 0.142 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.215451e-01 0.142 0 0
COPII-mediated vesicle transport R-HSA-204005 7.233158e-01 0.141 0 0
Interleukin-17 signaling R-HSA-448424 7.233158e-01 0.141 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.233158e-01 0.141 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.233158e-01 0.141 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.242418e-01 0.140 0 0
Translesion Synthesis by POLH R-HSA-110320 7.242418e-01 0.140 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.242418e-01 0.140 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.242418e-01 0.140 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.242418e-01 0.140 0 0
Diseases of hemostasis R-HSA-9671793 7.242418e-01 0.140 0 0
DNA Damage Bypass R-HSA-73893 7.247632e-01 0.140 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.297052e-01 0.137 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.297052e-01 0.137 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.297052e-01 0.137 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.297052e-01 0.137 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.297052e-01 0.137 0 0
GABA receptor activation R-HSA-977443 7.297052e-01 0.137 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.298347e-01 0.137 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.351506e-01 0.134 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.361683e-01 0.133 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.361683e-01 0.133 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.361683e-01 0.133 0 0
Interleukin-2 family signaling R-HSA-451927 7.361683e-01 0.133 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.361683e-01 0.133 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.368877e-01 0.133 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.368877e-01 0.133 0 0
PI3K Cascade R-HSA-109704 7.384457e-01 0.132 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.384457e-01 0.132 0 0
MAP kinase activation R-HSA-450294 7.421681e-01 0.129 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.421681e-01 0.129 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.447030e-01 0.128 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.447030e-01 0.128 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.447030e-01 0.128 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.447030e-01 0.128 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.447030e-01 0.128 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.447030e-01 0.128 0 0
Protein hydroxylation R-HSA-9629569 7.447030e-01 0.128 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.447030e-01 0.128 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.496972e-01 0.125 0 0
Binding and entry of HIV virion R-HSA-173107 7.496972e-01 0.125 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.496972e-01 0.125 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.496972e-01 0.125 0 0
DNA replication initiation R-HSA-68952 7.496972e-01 0.125 0 0
Arachidonate production from DAG R-HSA-426048 7.496972e-01 0.125 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.496972e-01 0.125 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.496972e-01 0.125 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.496972e-01 0.125 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.496972e-01 0.125 0 0
Josephin domain DUBs R-HSA-5689877 7.496972e-01 0.125 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.496972e-01 0.125 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.507802e-01 0.124 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.507802e-01 0.124 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.507802e-01 0.124 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.514649e-01 0.124 0 0
HSF1-dependent transactivation R-HSA-3371571 7.516232e-01 0.124 0 0
Downstream signal transduction R-HSA-186763 7.533955e-01 0.123 0 0
Cargo concentration in the ER R-HSA-5694530 7.533955e-01 0.123 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.533955e-01 0.123 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.612735e-01 0.118 0 0
PI Metabolism R-HSA-1483255 7.615528e-01 0.118 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.638474e-01 0.117 0 0
Lagging Strand Synthesis R-HSA-69186 7.638474e-01 0.117 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.638474e-01 0.117 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.638474e-01 0.117 0 0
Signalling to RAS R-HSA-167044 7.638474e-01 0.117 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.638474e-01 0.117 0 0
Basigin interactions R-HSA-210991 7.638474e-01 0.117 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.642995e-01 0.117 0 0
Neurexins and neuroligins R-HSA-6794361 7.642995e-01 0.117 0 0
HIV Transcription Initiation R-HSA-167161 7.647622e-01 0.116 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.647622e-01 0.116 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.647622e-01 0.116 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.647622e-01 0.116 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.690590e-01 0.114 0 0
Meiosis R-HSA-1500620 7.718490e-01 0.112 0 0
LGI-ADAM interactions R-HSA-5682910 7.750045e-01 0.111 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.750045e-01 0.111 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.750045e-01 0.111 0 0
vRNA Synthesis R-HSA-192814 7.750045e-01 0.111 0 0
Synthesis of PI R-HSA-1483226 7.750045e-01 0.111 0 0
Interleukin-2 signaling R-HSA-9020558 7.750045e-01 0.111 0 0
Bicarbonate transporters R-HSA-425381 7.750045e-01 0.111 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.750045e-01 0.111 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.750045e-01 0.111 0 0
PECAM1 interactions R-HSA-210990 7.750045e-01 0.111 0 0
Suppression of apoptosis R-HSA-9635465 7.750045e-01 0.111 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.750045e-01 0.111 0 0
Adherens junctions interactions R-HSA-418990 7.754651e-01 0.110 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.764798e-01 0.110 0 0
Meiotic synapsis R-HSA-1221632 7.764798e-01 0.110 0 0
Insulin receptor signalling cascade R-HSA-74751 7.770576e-01 0.110 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.781245e-01 0.109 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.789252e-01 0.109 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.795337e-01 0.108 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.817319e-01 0.107 0 0
Glutathione synthesis and recycling R-HSA-174403 7.817319e-01 0.107 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.817319e-01 0.107 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.839003e-01 0.106 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.839003e-01 0.106 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.839003e-01 0.106 1 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.839003e-01 0.106 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.839003e-01 0.106 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.881517e-01 0.103 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.881517e-01 0.103 0 0
UCH proteinases R-HSA-5689603 7.889849e-01 0.103 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.889849e-01 0.103 0 0
Parasitic Infection Pathways R-HSA-9824443 7.890455e-01 0.103 0 0
Leishmania infection R-HSA-9658195 7.890455e-01 0.103 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.908786e-01 0.102 0 0
Signaling by FGFR4 R-HSA-5654743 7.908786e-01 0.102 1 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.908786e-01 0.102 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.917753e-01 0.101 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.977545e-01 0.098 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 7.977545e-01 0.098 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.977545e-01 0.098 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.977545e-01 0.098 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.977545e-01 0.098 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.977545e-01 0.098 0 0
Anchoring fibril formation R-HSA-2214320 7.977545e-01 0.098 0 0
DS-GAG biosynthesis R-HSA-2022923 7.977545e-01 0.098 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.977545e-01 0.098 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.979435e-01 0.098 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.979435e-01 0.098 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.979435e-01 0.098 0 0
rRNA processing R-HSA-72312 7.983088e-01 0.098 0 0
FGFR2 alternative splicing R-HSA-6803529 7.984157e-01 0.098 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.984157e-01 0.098 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.984157e-01 0.098 0 0
LDL clearance R-HSA-8964038 7.984157e-01 0.098 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.984157e-01 0.098 0 0
Translation of Structural Proteins R-HSA-9694635 7.986967e-01 0.098 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.030379e-01 0.095 0 0
RMTs methylate histone arginines R-HSA-3214858 8.030379e-01 0.095 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.046486e-01 0.094 0 0
RNA Polymerase I Transcription R-HSA-73864 8.080648e-01 0.093 0 0
Ub-specific processing proteases R-HSA-5689880 8.081446e-01 0.093 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.082962e-01 0.092 0 0
Peptide chain elongation R-HSA-156902 8.089198e-01 0.092 0 0
Ion homeostasis R-HSA-5578775 8.101159e-01 0.091 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.103868e-01 0.091 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.103868e-01 0.091 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.103868e-01 0.091 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.112142e-01 0.091 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.112142e-01 0.091 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.112142e-01 0.091 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.112142e-01 0.091 1 0
Mitophagy R-HSA-5205647 8.112142e-01 0.091 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.112142e-01 0.091 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.112142e-01 0.091 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.139586e-01 0.089 0 0
Interleukin-20 family signaling R-HSA-8854691 8.139586e-01 0.089 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.139586e-01 0.089 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.139586e-01 0.089 0 0
Signaling by Interleukins R-HSA-449147 8.146023e-01 0.089 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.146170e-01 0.089 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.146170e-01 0.089 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.146170e-01 0.089 0 0
Sensory processing of sound R-HSA-9659379 8.170938e-01 0.088 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.182053e-01 0.087 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.182053e-01 0.087 0 0
MET activates RAS signaling R-HSA-8851805 8.182053e-01 0.087 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.182053e-01 0.087 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.182053e-01 0.087 0 0
Synthesis of GDP-mannose R-HSA-446205 8.182053e-01 0.087 0 0
Polymerase switching R-HSA-69091 8.182053e-01 0.087 0 0
Leading Strand Synthesis R-HSA-69109 8.182053e-01 0.087 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.182053e-01 0.087 0 0
OAS antiviral response R-HSA-8983711 8.182053e-01 0.087 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.198516e-01 0.086 0 0
HCMV Early Events R-HSA-9609690 8.216120e-01 0.085 0 0
Mitochondrial biogenesis R-HSA-1592230 8.221823e-01 0.085 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.237398e-01 0.084 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.237398e-01 0.084 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.237398e-01 0.084 0 0
Regulation of Apoptosis R-HSA-169911 8.237398e-01 0.084 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.256314e-01 0.083 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.256314e-01 0.083 0 0
Diseases of DNA repair R-HSA-9675135 8.256314e-01 0.083 0 0
Neurotransmitter release cycle R-HSA-112310 8.256509e-01 0.083 0 0
Base Excision Repair R-HSA-73884 8.256509e-01 0.083 0 0
FOXO-mediated transcription R-HSA-9614085 8.263272e-01 0.083 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.284206e-01 0.082 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.284206e-01 0.082 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.355481e-01 0.078 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.355481e-01 0.078 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.360977e-01 0.078 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.360977e-01 0.078 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.365893e-01 0.077 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.365893e-01 0.077 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.365893e-01 0.077 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.365893e-01 0.077 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.365893e-01 0.077 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.365893e-01 0.077 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.365893e-01 0.077 0 0
Regulation of beta-cell development R-HSA-186712 8.395873e-01 0.076 0 0
Signaling by NOTCH R-HSA-157118 8.402562e-01 0.076 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.412216e-01 0.075 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.418615e-01 0.075 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.418615e-01 0.075 0 0
Formation of the nephric duct R-HSA-9830364 8.418615e-01 0.075 0 0
Tight junction interactions R-HSA-420029 8.418615e-01 0.075 0 0
Influenza Infection R-HSA-168255 8.431594e-01 0.074 0 0
Cell-cell junction organization R-HSA-421270 8.433743e-01 0.074 0 0
Interferon gamma signaling R-HSA-877300 8.438689e-01 0.074 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.440666e-01 0.074 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.444437e-01 0.073 0 0
Co-stimulation by CD28 R-HSA-389356 8.460330e-01 0.073 0 0
Degradation of AXIN R-HSA-4641257 8.466679e-01 0.072 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.466679e-01 0.072 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.483883e-01 0.071 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.483883e-01 0.071 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.485358e-01 0.071 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.485839e-01 0.071 0 0
tRNA processing R-HSA-72306 8.515470e-01 0.070 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.525659e-01 0.069 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.531151e-01 0.069 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.531151e-01 0.069 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.531151e-01 0.069 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.531151e-01 0.069 0 0
Hydrolysis of LPC R-HSA-1483115 8.531151e-01 0.069 0 0
Prolactin receptor signaling R-HSA-1170546 8.531151e-01 0.069 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.531151e-01 0.069 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.531151e-01 0.069 0 0
Ciprofloxacin ADME R-HSA-9793528 8.531151e-01 0.069 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.531151e-01 0.069 0 0
Zinc transporters R-HSA-435354 8.531151e-01 0.069 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.537502e-01 0.069 0 0
MET activates PTK2 signaling R-HSA-8874081 8.543397e-01 0.068 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.543397e-01 0.068 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.543397e-01 0.068 0 0
TRP channels R-HSA-3295583 8.543397e-01 0.068 0 0
Urea cycle R-HSA-70635 8.543397e-01 0.068 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.543397e-01 0.068 0 0
Neutrophil degranulation R-HSA-6798695 8.548483e-01 0.068 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.548707e-01 0.068 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.554550e-01 0.068 0 0
G alpha (s) signalling events R-HSA-418555 8.567973e-01 0.067 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.571281e-01 0.067 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.571281e-01 0.067 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.613361e-01 0.065 0 0
Signaling by PDGF R-HSA-186797 8.651920e-01 0.063 0 0
Mitochondrial protein import R-HSA-1268020 8.651920e-01 0.063 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.651920e-01 0.063 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.659125e-01 0.063 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.659125e-01 0.063 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.659125e-01 0.063 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.659125e-01 0.063 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.659125e-01 0.063 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.659125e-01 0.063 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.659125e-01 0.063 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.669579e-01 0.062 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.669579e-01 0.062 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.669579e-01 0.062 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.669579e-01 0.062 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.679706e-01 0.061 0 0
Translesion synthesis by REV1 R-HSA-110312 8.679706e-01 0.061 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.679706e-01 0.061 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.679706e-01 0.061 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.679706e-01 0.061 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.679706e-01 0.061 0 0
Erythropoietin activates RAS R-HSA-9027284 8.679706e-01 0.061 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.679706e-01 0.061 0 0
p38MAPK events R-HSA-171007 8.679706e-01 0.061 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.679706e-01 0.061 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.679706e-01 0.061 0 0
DNA Damage Reversal R-HSA-73942 8.679706e-01 0.061 0 0
p75NTR signals via NF-kB R-HSA-193639 8.679706e-01 0.061 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.712980e-01 0.060 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.728316e-01 0.059 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.753423e-01 0.058 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.761864e-01 0.057 0 0
Attenuation phase R-HSA-3371568 8.761864e-01 0.057 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.761864e-01 0.057 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.761864e-01 0.057 0 0
Generation of second messenger molecules R-HSA-202433 8.761864e-01 0.057 0 0
HIV elongation arrest and recovery R-HSA-167287 8.766354e-01 0.057 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.766354e-01 0.057 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.766354e-01 0.057 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.766354e-01 0.057 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.796656e-01 0.056 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.808230e-01 0.055 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.808230e-01 0.055 0 0
Translesion synthesis by POLI R-HSA-5656121 8.813244e-01 0.055 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.813244e-01 0.055 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.813244e-01 0.055 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.813244e-01 0.055 0 0
Attachment and Entry R-HSA-9678110 8.813244e-01 0.055 0 0
Mitochondrial Uncoupling R-HSA-166187 8.813244e-01 0.055 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.813244e-01 0.055 0 0
Differentiation of T cells R-HSA-9945266 8.813244e-01 0.055 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.813890e-01 0.055 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.865617e-01 0.052 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.865617e-01 0.052 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.865617e-01 0.052 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.865617e-01 0.052 0 0
Signaling by Erythropoietin R-HSA-9006335 8.865617e-01 0.052 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.865617e-01 0.052 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.883742e-01 0.051 0 0
Smooth Muscle Contraction R-HSA-445355 8.883742e-01 0.051 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.883742e-01 0.051 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.883956e-01 0.051 0 0
Stimuli-sensing channels R-HSA-2672351 8.906461e-01 0.050 0 0
Developmental Cell Lineages R-HSA-9734767 8.921279e-01 0.050 0 0
Signaling by FGFR R-HSA-190236 8.927552e-01 0.049 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.927552e-01 0.049 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.927552e-01 0.049 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.927552e-01 0.049 0 0
Cellular response to starvation R-HSA-9711097 8.928201e-01 0.049 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.929534e-01 0.049 0 0
Translation of Structural Proteins R-HSA-9683701 8.929534e-01 0.049 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.933283e-01 0.049 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.933283e-01 0.049 0 0
Translesion synthesis by POLK R-HSA-5655862 8.933283e-01 0.049 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.933283e-01 0.049 0 0
Glycine degradation R-HSA-6783984 8.933283e-01 0.049 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.933283e-01 0.049 0 0
Passive transport by Aquaporins R-HSA-432047 8.933283e-01 0.049 0 0
Fibronectin matrix formation R-HSA-1566977 8.933283e-01 0.049 0 0
Coenzyme A biosynthesis R-HSA-196783 8.933283e-01 0.049 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.933283e-01 0.049 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.933283e-01 0.049 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.933283e-01 0.049 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.938995e-01 0.049 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.957430e-01 0.048 0 0
DAP12 signaling R-HSA-2424491 8.957430e-01 0.048 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.957430e-01 0.048 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.968922e-01 0.047 1 0
Ribosome-associated quality control R-HSA-9948299 8.973733e-01 0.047 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.005481e-01 0.045 0 0
Glycogen storage diseases R-HSA-3229121 9.041186e-01 0.044 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.041186e-01 0.044 0 0
Catecholamine biosynthesis R-HSA-209905 9.041186e-01 0.044 0 0
Choline catabolism R-HSA-6798163 9.041186e-01 0.044 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.042283e-01 0.044 0 0
Signaling by FGFR2 R-HSA-5654738 9.057249e-01 0.043 1 0
Selenocysteine synthesis R-HSA-2408557 9.080847e-01 0.042 0 0
Signaling by FGFR1 R-HSA-5654736 9.085700e-01 0.042 1 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.085700e-01 0.042 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.127624e-01 0.040 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.132838e-01 0.039 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.138181e-01 0.039 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.138181e-01 0.039 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.138181e-01 0.039 0 0
Tie2 Signaling R-HSA-210993 9.138181e-01 0.039 0 0
GAB1 signalosome R-HSA-180292 9.138181e-01 0.039 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.138181e-01 0.039 0 0
Cyclin D associated events in G1 R-HSA-69231 9.142949e-01 0.039 0 0
G1 Phase R-HSA-69236 9.142949e-01 0.039 0 0
Neuronal System R-HSA-112316 9.144442e-01 0.039 0 0
Hemostasis R-HSA-109582 9.148151e-01 0.039 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.160946e-01 0.038 0 0
Signaling by Insulin receptor R-HSA-74752 9.162599e-01 0.038 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.166597e-01 0.038 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.192960e-01 0.037 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.192960e-01 0.037 0 0
Cardiogenesis R-HSA-9733709 9.192960e-01 0.037 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.195857e-01 0.036 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.201638e-01 0.036 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.225368e-01 0.035 0 0
Regulation of signaling by CBL R-HSA-912631 9.225368e-01 0.035 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.225368e-01 0.035 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.225368e-01 0.035 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.225368e-01 0.035 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.225368e-01 0.035 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.225368e-01 0.035 0 0
PPARA activates gene expression R-HSA-1989781 9.239852e-01 0.034 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.254514e-01 0.034 0 0
Heme degradation R-HSA-189483 9.259649e-01 0.033 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.259649e-01 0.033 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.265273e-01 0.033 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.266295e-01 0.033 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.294898e-01 0.032 0 0
Interferon alpha/beta signaling R-HSA-909733 9.303172e-01 0.031 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.303739e-01 0.031 0 0
Glycogen synthesis R-HSA-3322077 9.303739e-01 0.031 0 0
Pregnenolone biosynthesis R-HSA-196108 9.303739e-01 0.031 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.303739e-01 0.031 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.303739e-01 0.031 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.303739e-01 0.031 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.303739e-01 0.031 0 0
Signaling by NODAL R-HSA-1181150 9.303739e-01 0.031 0 0
Nephrin family interactions R-HSA-373753 9.303739e-01 0.031 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.304216e-01 0.031 0 0
tRNA Aminoacylation R-HSA-379724 9.304216e-01 0.031 0 0
Glutathione conjugation R-HSA-156590 9.304216e-01 0.031 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.321110e-01 0.031 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.321110e-01 0.031 0 0
Hyaluronan metabolism R-HSA-2142845 9.321110e-01 0.031 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.321110e-01 0.031 0 0
Collagen degradation R-HSA-1442490 9.350903e-01 0.029 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.357299e-01 0.029 1 0
Signaling by NOTCH4 R-HSA-9013694 9.358090e-01 0.029 0 0
Metal ion SLC transporters R-HSA-425410 9.367254e-01 0.028 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.367548e-01 0.028 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.374186e-01 0.028 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.374186e-01 0.028 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.374186e-01 0.028 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.374186e-01 0.028 0 0
Phenylalanine metabolism R-HSA-8964208 9.374186e-01 0.028 0 0
ERK/MAPK targets R-HSA-198753 9.374186e-01 0.028 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.374186e-01 0.028 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.374186e-01 0.028 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.374186e-01 0.028 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.377718e-01 0.028 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.377718e-01 0.028 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.377718e-01 0.028 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.394729e-01 0.027 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.398396e-01 0.027 0 0
Iron uptake and transport R-HSA-917937 9.398396e-01 0.027 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.401351e-01 0.027 0 0
Telomere Maintenance R-HSA-157579 9.404020e-01 0.027 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.410624e-01 0.026 0 0
Developmental Biology R-HSA-1266738 9.417088e-01 0.026 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.429825e-01 0.025 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.429825e-01 0.025 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.433554e-01 0.025 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.435071e-01 0.025 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.435071e-01 0.025 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.437509e-01 0.025 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.437509e-01 0.025 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.437509e-01 0.025 0 0
Assembly Of The HIV Virion R-HSA-175474 9.437509e-01 0.025 0 0
Attachment and Entry R-HSA-9694614 9.437509e-01 0.025 0 0
Ribavirin ADME R-HSA-9755088 9.437509e-01 0.025 0 0
HCMV Infection R-HSA-9609646 9.456294e-01 0.024 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.457806e-01 0.024 0 0
Azathioprine ADME R-HSA-9748787 9.457806e-01 0.024 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.464219e-01 0.024 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.464219e-01 0.024 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.475865e-01 0.023 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.477764e-01 0.023 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.477764e-01 0.023 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.494427e-01 0.023 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.494427e-01 0.023 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.494427e-01 0.023 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.494427e-01 0.023 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.494427e-01 0.023 0 0
Cellular hexose transport R-HSA-189200 9.494427e-01 0.023 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.494427e-01 0.023 0 0
Cardiac conduction R-HSA-5576891 9.495415e-01 0.022 0 0
Meiotic recombination R-HSA-912446 9.498421e-01 0.022 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.519087e-01 0.021 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.519087e-01 0.021 0 0
Interleukin-1 signaling R-HSA-9020702 9.528596e-01 0.021 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.543234e-01 0.020 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.545405e-01 0.020 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.545589e-01 0.020 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.545589e-01 0.020 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.545589e-01 0.020 0 0
Carnitine shuttle R-HSA-200425 9.545589e-01 0.020 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.547570e-01 0.020 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.562351e-01 0.019 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.591577e-01 0.018 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.591577e-01 0.018 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.591577e-01 0.018 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.591577e-01 0.018 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.597448e-01 0.018 0 0
HIV Transcription Elongation R-HSA-167169 9.599562e-01 0.018 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.599562e-01 0.018 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.599562e-01 0.018 0 0
Diseases of Immune System R-HSA-5260271 9.599562e-01 0.018 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.603865e-01 0.018 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.603865e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.605611e-01 0.017 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.616843e-01 0.017 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.619137e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.632913e-01 0.016 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.632913e-01 0.016 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.632913e-01 0.016 0 0
Laminin interactions R-HSA-3000157 9.632913e-01 0.016 0 0
Hyaluronan degradation R-HSA-2160916 9.632913e-01 0.016 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.632913e-01 0.016 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.632913e-01 0.016 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.633726e-01 0.016 0 0
Maturation of spike protein R-HSA-9694548 9.633726e-01 0.016 0 0
HDACs deacetylate histones R-HSA-3214815 9.634117e-01 0.016 0 0
Paracetamol ADME R-HSA-9753281 9.634117e-01 0.016 0 0
Collagen formation R-HSA-1474290 9.645746e-01 0.016 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.659172e-01 0.015 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.665079e-01 0.015 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.667854e-01 0.015 0 0
Metalloprotease DUBs R-HSA-5689901 9.670067e-01 0.015 0 0
Sphingolipid catabolism R-HSA-9845614 9.670067e-01 0.015 0 0
Abacavir ADME R-HSA-2161522 9.670067e-01 0.015 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.670067e-01 0.015 0 0
Eukaryotic Translation Termination R-HSA-72764 9.688691e-01 0.014 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.689538e-01 0.014 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.689538e-01 0.014 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.693841e-01 0.014 0 0
Depyrimidination R-HSA-73928 9.693841e-01 0.014 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.703463e-01 0.013 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.703463e-01 0.013 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.703463e-01 0.013 0 0
Cristae formation R-HSA-8949613 9.703463e-01 0.013 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.703463e-01 0.013 0 0
Triglyceride biosynthesis R-HSA-75109 9.703463e-01 0.013 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.703463e-01 0.013 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.703463e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.703463e-01 0.013 0 0
Insulin processing R-HSA-264876 9.703463e-01 0.013 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.703463e-01 0.013 0 0
Potassium Channels R-HSA-1296071 9.708321e-01 0.013 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.720214e-01 0.012 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.733480e-01 0.012 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.733480e-01 0.012 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.733480e-01 0.012 0 0
Insulin receptor recycling R-HSA-77387 9.733480e-01 0.012 0 0
Peroxisomal protein import R-HSA-9033241 9.734678e-01 0.012 0 0
TCR signaling R-HSA-202403 9.744125e-01 0.011 0 0
DAP12 interactions R-HSA-2172127 9.744386e-01 0.011 0 0
Surfactant metabolism R-HSA-5683826 9.744386e-01 0.011 0 0
Metabolism of polyamines R-HSA-351202 9.755370e-01 0.011 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.760461e-01 0.011 0 0
mRNA Capping R-HSA-72086 9.760461e-01 0.011 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.760461e-01 0.011 0 0
ABC-family proteins mediated transport R-HSA-382556 9.775971e-01 0.010 0 0
ER-Phagosome pathway R-HSA-1236974 9.782966e-01 0.010 0 0
HCMV Late Events R-HSA-9610379 9.784653e-01 0.009 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.784711e-01 0.009 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.786819e-01 0.009 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.786819e-01 0.009 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.786819e-01 0.009 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.786819e-01 0.009 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.805391e-01 0.009 0 0
Synthesis of PC R-HSA-1483191 9.805391e-01 0.009 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.806508e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.806508e-01 0.008 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.806508e-01 0.008 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.806508e-01 0.008 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.806508e-01 0.008 0 0
Integrin cell surface interactions R-HSA-216083 9.812587e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.812587e-01 0.008 0 0
Viral mRNA Translation R-HSA-192823 9.816816e-01 0.008 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.821596e-01 0.008 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.825305e-01 0.008 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.826099e-01 0.008 0 0
Platelet degranulation R-HSA-114608 9.835814e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.843708e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.848145e-01 0.007 0 0
Striated Muscle Contraction R-HSA-390522 9.859534e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.859534e-01 0.006 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.859534e-01 0.006 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.859534e-01 0.006 0 0
Muscle contraction R-HSA-397014 9.862689e-01 0.006 0 0
Translation R-HSA-72766 9.863660e-01 0.006 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.865174e-01 0.006 0 0
The phototransduction cascade R-HSA-2514856 9.865174e-01 0.006 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.872382e-01 0.006 0 0
eNOS activation R-HSA-203615 9.873759e-01 0.006 0 0
Signaling by NOTCH2 R-HSA-1980145 9.873759e-01 0.006 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.873759e-01 0.006 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.873759e-01 0.006 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.881927e-01 0.005 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.886544e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.886544e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.887505e-01 0.005 0 0
Glycosphingolipid transport R-HSA-9845576 9.898035e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.898035e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.908362e-01 0.004 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.908362e-01 0.004 0 0
Cleavage of the damaged purine R-HSA-110331 9.908362e-01 0.004 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.908362e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.908362e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.917644e-01 0.004 0 0
Depurination R-HSA-73927 9.917644e-01 0.004 0 0
Purine salvage R-HSA-74217 9.917644e-01 0.004 0 0
Elastic fibre formation R-HSA-1566948 9.917644e-01 0.004 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.917644e-01 0.004 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.922788e-01 0.003 0 0
SARS-CoV Infections R-HSA-9679506 9.923052e-01 0.003 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.923650e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.925987e-01 0.003 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.929653e-01 0.003 0 0
Downstream TCR signaling R-HSA-202424 9.932000e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.932000e-01 0.003 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.933485e-01 0.003 0 0
Glycogen metabolism R-HSA-8982491 9.933485e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.933485e-01 0.003 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.933485e-01 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.935776e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.935945e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.937313e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.937313e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.937313e-01 0.003 0 0
Protein localization R-HSA-9609507 9.939746e-01 0.003 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.940223e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.941685e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.942746e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.946280e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.946280e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.946280e-01 0.002 0 0
Endogenous sterols R-HSA-211976 9.946920e-01 0.002 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.951693e-01 0.002 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.954666e-01 0.002 0 0
Neddylation R-HSA-8951664 9.956514e-01 0.002 0 0
Defective pyroptosis R-HSA-9710421 9.956615e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.957232e-01 0.002 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.958040e-01 0.002 0 0
Ion transport by P-type ATPases R-HSA-936837 9.960010e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.961011e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.961011e-01 0.002 0 0
Methylation R-HSA-156581 9.961011e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.961011e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.964962e-01 0.002 0 0
Ion channel transport R-HSA-983712 9.968975e-01 0.001 0 0
Kidney development R-HSA-9830369 9.969915e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.969915e-01 0.001 0 0
Potential therapeutics for SARS R-HSA-9679191 9.970118e-01 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 9.970576e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.970599e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.972408e-01 0.001 0 0
Toll-like Receptor Cascades R-HSA-168898 9.972624e-01 0.001 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.974292e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.974572e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.975347e-01 0.001 0 0
Adaptive Immune System R-HSA-1280218 9.977038e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.977150e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.977150e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.977396e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.978746e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.979457e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.981332e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.981548e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.983037e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.983038e-01 0.001 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.987968e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.988422e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.988914e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.989188e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.989516e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.989516e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.990285e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.990481e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.990481e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.990656e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.991350e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.992156e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.993484e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993666e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.995244e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.995405e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.996029e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996666e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996666e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996666e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.996770e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.996785e-01 0.000 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.997255e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.997405e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.997827e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997827e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997827e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997827e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998048e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998214e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998424e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998424e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.998562e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998650e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.998821e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998892e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998973e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998996e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.999255e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999303e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999324e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999435e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999608e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999615e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999663e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999695e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999758e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999820e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999866e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999880e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999892e-01 0.000 0 0
Immune System R-HSA-168256 9.999901e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999905e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999917e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999959e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999960e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999962e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999965e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999966e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999981e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999985e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999987e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999989e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999991e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999991e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999991e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999993e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999993e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999997e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999998e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways