DSTYK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A6NMY6	S164	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O00151	T80	Sugiyama	PDLIM1 CLIM1 CLP36	NMTHLEAQNRIKGCTDNLtLtVARsEHKVWsPLVtEEGKRH
O00193	S87	Sugiyama	SMAP C11orf58	FRTGEEDKKINEELEsQyQQsMDsKLSGRYRRHCGLGFSEV
O00443	S108	Sugiyama	PIK3C2A	LDIDVEKLTQAELEKLLLDDsFETKKTPVLPVTPILSPSFS
O00625	S225	Sugiyama	PIR	PDDAQQKIEPHHTAVLGEGDsVQVENKDPKRSHFVLIAGEP
O14763	S425	Sugiyama	TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186	ALETLGERLAKQKIEDHLLSsGKFMYLEGNADSAMS_____
O14979	S293	Sugiyama	HNRNPDL HNRPDL JKTBP	RRGFCFITYTDEEPVKKLLEsRYHQIGSGKCEIKVAQPKEV
O15212	S53	Sugiyama	PFDN6 HKE2 PFD6	LEAQLtENNIVKEELALLDGsNVVFKLLGPVLVKQELGEAR
O15355	S363	Sugiyama	PPM1G PPM1C	VANAGDsRCVVsEAGKALDMsyDHKPEDEVELARIKNAGGK
O15371	T49	Sugiyama	EIF3D EIF3S7	PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43399	S103	Sugiyama	TPD52L2	LstLGELKQNLsRsWHDVQVssAyVKTSEKLGEWNEKVTQS
O43399	S21	Sugiyama	TPD52L2	MDsAGQDINLNsPNKGLLsDsMtDVPVDTGVAARtPAVEGL
O43852	S125	Sugiyama	CALU	IyEDVERQWKGHDLNEDGLVsWEEyKNATYGYVLDDPDPDD
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60271	S109	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	YEREKALRKHAEEKFIEFEDsQEQEKKDLQTRVESLESQTR
O60664	S225	Sugiyama	PLIN3 M6PRBP1 TIP47	PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60664	S93	Sugiyama	PLIN3 M6PRBP1 TIP47	AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60749	S264	Sugiyama	SNX2 TRG9	QRTVKHPTLLQDPDLRQFLEssELPRAVNTQALsGAGILRM
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60831	S19	Sugiyama	PRAF2 JM4	__MSEVRLPPLRALDDFVLGsARLAAPDPCDPQRWCHRVIN
O60841	S196	Sugiyama	EIF5B IF2 KIAA0741	ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60927	T75	Sugiyama	PPP1R11 HCGV TCTE5	RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75347	S103	Sugiyama	TBCA	ENEKDLEEAEEyKEARLVLDsVKLEA_______________
O75391	S63	Sugiyama	SPAG7	QQKVEFRKRMEKEVsDFIQDsGQIKKKFQPMNKIERSILHD
O75534	S766	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	AAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDNsMGFG
O75821	S189	Sugiyama	EIF3G EIF3S4	CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95218	S188	Sugiyama	ZRANB2 ZIS ZNF265	KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95721	S210	Sugiyama	SNAP29	PKNPHLRAYHQKIDsNLDELsMGLGRLKDIALGMQTEIEEQ
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95816	S31	Sugiyama	BAG2	NEGRFCRsssMADRsSRLLEsLDQLELRVEALREAATAVEQ
P00338	S167	Sugiyama	LDHA PIG19	AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00338	S237	Sugiyama	LDHA PIG19	DLGtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVA
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	T394	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083	S201	Sugiyama	ANXA1 ANX1 LPC1	LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04150	S125	Sugiyama	NR3C1 GRL	PQQGQISLSSGETDLKLLEEsIANLNRstsVPENPKSSAST
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05783	S323	Sugiyama	KRT18 CYK18 PIG46	VQsLEIDLDsMRNLKAsLENsLREVEARYALQMEQLNGILL
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	S168	Sugiyama	LDHB	TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	T394	Sugiyama	PGK2 PGKB	GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237	T85	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355	S164	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T107	Sugiyama	TUBB TUBB5 OK/SW-cl.56	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKEAESC
P07737	S85	Sugiyama	PFN1	tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864	S167	Sugiyama	LDHC LDH3 LDHX	VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900	S165	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900	S263	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900	S391	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900	T171	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900	T645	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	T401	Sugiyama	SLC3A2 MDU1	NSSDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQ
P08195	T415	Sugiyama	SLC3A2 MDU1	NKDLLLtssyLsDsGstGEHtKSLVTQYLNATGNRWCSWSL
P08195	T599	Sugiyama	SLC3A2 MDU1	QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238	S160	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238	S383	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	T166	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	T637	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P09429	S35	Sugiyama	HMGB1 HMG1	syAFFVQtCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAK
P09661	S212	Sugiyama	SNRPA1	KKGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGR
P09661	S226	Sugiyama	SNRPA1	NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7	T73	Sugiyama	TUBA3C TUBA2	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7	T80	Sugiyama	TUBA3C TUBA2	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P0DPH7	T82	Sugiyama	TUBA3C TUBA2	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANN
P0DPH7	Y83	Sugiyama	TUBA3C TUBA2	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANNy
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809	S398	Sugiyama	HSPD1 HSP60	LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	S362	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	RIPKIQKLLQDFFNGKELNKsINPDEAVAyGAAVQAAILsG
P11142	S544	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KYKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKIND
P11142	S85	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11586	T128	Sugiyama	MTHFD1 MTHFC MTHFD	SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P12277	S164	Sugiyama	CKB CKBB	PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P13073	S74	Sugiyama	COX4I1 COX4	HLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFAEMN
P13489	T176	Sugiyama	RNH1 PRI RNH	AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13987	T76	Sugiyama	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P13987	T85	Sugiyama	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	WKFEHCNFNDVtTRLRENELtyyCCKKDLCNFNEQLENGGT
P14209	S168	Sugiyama	CD99 MIC2 MIC2X MIC2Y	YQKKKLCFKENAEQGEVDMEsHRNANAEPAVQRtLLEK___
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P15311	S413	Sugiyama	EZR VIL2	RMAALRAKEELERQAVDQIKsQEQLAAELAEytAKIALLEE
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T425	Sugiyama	EZR VIL2	RQAVDQIKsQEQLAAELAEytAKIALLEEARRRKEDEVEEW
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15374	S126	Sugiyama	UCHL3	NNKDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17480	S364	Sugiyama	UBTF UBF UBF1	HKKCDQKKKDyEVELLRFLEsLPEEEQQRVLGEEKMLNINK
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P17987	Y545	Sugiyama	TCP1 CCT1 CCTA	LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P18206	S820	Sugiyama	VCL	DAKAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEP
P18621	S111	Sugiyama	RPL17	LLHMLKNAESNAELKGLDVDsLVIEHIQVNKAPKMRRRTYR
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338	Y462	Sugiyama	NCL	AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20042	S67	Sugiyama	EIF2S2 EIF2B	EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20618	S157	Sugiyama	PSMB1 PSC5	IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20674	T105	Sugiyama	COX5A	EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P20810	S295	Sugiyama	CAST	QEKKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEV
P20810	S297	Sugiyama	CAST	KKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEVDE
P20810	S379	Sugiyama	CAST	KPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTEESKAAA
P22692	S255	Sugiyama	IGFBP4 IBP4	VKLPGGLEPKGELDCHQLADsFRE_________________
P23246	S283	Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23921	S780	Sugiyama	RRM1 RR1	KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P24752	S218	Sugiyama	ACAT1 ACAT MAT	ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV
P25788	S243	Sugiyama	PSMA3 HC8 PSC8	GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25815	S47	Sugiyama	S100P S100E	tLTKGELKVLMEKELPGFLQsGKDKDAVDKLLKDLDANGDA
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26038	T425	Sugiyama	MSN	QAsRDQKKTQEQLALEMAELtARIsQLEMARQKKEsEAVEW
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639	S522	Sugiyama	TARS1 TARS	PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348	S145	Sugiyama	YWHAQ	YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348	S156	Sugiyama	YWHAQ	DDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLGLALNFSV
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	S53	Sugiyama	CALR CRTC	WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P29144	S93	Sugiyama	TPP2	SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401	S332	Sugiyama	TKT	GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29401	S548	Sugiyama	TKT	NIRVLDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGI
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30041	S186	Sugiyama	PRDX6 AOP2 KIAA0106	SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30048	S86	Sugiyama	PRDX3 AOP1	TQHAPYFKGTAVVNGEFKDLsLDDFKGKYLVLFFYPLDFTF
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30086	S60	Sugiyama	PEBP1 PBP PEBP	VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30622	T731	Sugiyama	CLIP1 CYLN1 RSN	EAIRSKLDKAEDQHLVEMEDtLNKLQEAEIKVKELEVLQAK
P31948	S460	Sugiyama	STIP1	AMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRHD
P33176	S950	Sugiyama	KIF5B KNS KNS1	PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33316	S164	Sugiyama	DUT	YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P35579	S1308	Sugiyama	MYH9	LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579	S1376	Sugiyama	MYH9	EKQIATLHAQVADMKKKMEDsVGCLEtAEEVKRKLQKDLEG
P35579	S1714	Sugiyama	MYH9	RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579	T1313	Sugiyama	MYH9	DSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLstKLKQ
P35580	T1320	Sugiyama	MYH10	EKKGIKFAKDAAsLEsQLQDtQELLQEETRQKLNLSSRIRQ
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S240	Sugiyama	MATR3 KIAA0723	EDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGPL
P46776	Y108	Sugiyama	RPL27A	VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937	S388	Sugiyama	YAP1 YAP65	PGMsQELRTMttNssDPFLNsGtyHsRDEstDsGLsMssys
P48643	S270	Sugiyama	CCT5 CCTE KIAA0098	ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P49736	S170	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	KRRQVERAtEDGEEDEEMIEsIENLEDLKGHSVREWVsMAG
P51858	S239	Sugiyama	HDGF HMG1L2	DEEEEAtKEDAEAPGIRDHEsL___________________
P51946	S322	Sugiyama	CCNH	YVsKKSKHEEEEWtDDDLVEsL___________________
P53999	S10	Sugiyama	SUB1 PC4 RPO2TC1	___________MPKSKELVsssssGsDsDsEVDKKLKRKKQ
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S366	Sugiyama	CSE1L CAS XPO2	KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S106	Sugiyama	TPI1 TPI	DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	S97	Sugiyama	TPI1 TPI	GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60660	T85	Sugiyama	MYL6	LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61024	S9	Sugiyama	CKS1B CKS1 PNAS-143 PNAS-16	____________MSHKQIyysDKyDDEEFEyRHVMLPKDIA
P61254	S9	Sugiyama	RPL26	____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61604	S21	Sugiyama	HSPE1	MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	S139	Sugiyama	RPS14 PRO2640	LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62316	S30	Sugiyama	SNRPD2 SNRPD1	EMtPEELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNK
P62316	S35	Sugiyama	SNRPD2 SNRPD1	ELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGR
P62316	T33	Sugiyama	SNRPD2 SNRPD1	PEELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLL
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62857	S39	Sugiyama	RPS28	GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL
P62857	S41	Sugiyama	RPS28	tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62857	S61	Sugiyama	RPS28	sIIRNVKGPVREGDVLtLLEsEREARRLR____________
P62899	T22	Sugiyama	RPL31	APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	S138	Sugiyama	RPL8	EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979	S134	Sugiyama	RPS27A UBA80 UBCEP1	IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	T89	Sugiyama	YBX1 NSEP1 YB1	RNGyGFINRNDtKEDVFVHQtAIKKNNPRKyLRsVGDGEtV
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	T82	Sugiyama	TUBA1B	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78371	S144	Sugiyama	CCT2 99D8.1 CCTB	QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P78371	S60	Sugiyama	CCT2 99D8.1 CCTB	KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA
P78371	T69	Sugiyama	CCT2 99D8.1 CCTB	DKILLsSGRDAsLMVtNDGAtILKNIGVDNPAAKVLVDMSR
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00341	S216	Sugiyama	HDLBP HBP VGL	IKITGTKEGIEKARHEVLLIsAEQDKRAVERLEVEKAFHPF
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01814	S1242	Sugiyama	ATP2B2 PMCA2	DtsKSATSSsPGsPIHSLEtsL___________________
Q05682	S129	Sugiyama	CALD1 CAD CDM	KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q09666	S298	Sugiyama	AHNAK PM227	VDIsssLGGRAVEVQGPsLEsGDHGKIKFPTMKVPKFGVST
Q12906	S317	Sugiyama	ILF3 DRBF MPHOSPH4 NF90	KEAtDAIGHLDRQQREDItQsAQHALRLAAFGQLHKVLGMD
Q13283	S362	Sugiyama	G3BP1 G3BP	LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13435	S307	Sugiyama	SF3B2 SAP145	MNsQQEEEEMETDARssLGQsAsEtEEDtVsVsKKEKNRKR
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509	T107	Sugiyama	TUBB3 TUBB4	PDNFIFGQSGAGNNWAKGHytEGAELVDsVLDVVRKECENC
Q13561	T114	Sugiyama	DCTN2 DCTN50	GVKETPQQKYQRLLHEVQELtTEVEKIKTTVKEsATEEKLt
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885	T107	Sugiyama	TUBB2A TUBB2	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q14151	S207	Sugiyama	SAFB2 KIAA0138	FKNtLEtssLNFKVtPDIEEsLLEPENEKILDILGEtCKsE
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152	S1256	Sugiyama	EIF3A EIF3S10 KIAA0139	EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14257	T297	Sugiyama	RCN2 ERC55	LNGDKKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL
Q14568	S165	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568	T171	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14980	S1149	Sugiyama	NUMA1 NMP22 NUMA	VSKLEQQCQKQQEQADsLERsLEAERASRAERDsALEtLQG
Q15056	S110	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	DEVDsLKEALtyDGALLGDRsLRVDIAEGRKQDKGGFGFRK
Q15056	T100	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15084	S169	Sugiyama	PDIA6 ERP5 P5 TXNDC7	GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293	T211	Sugiyama	RCN1 RCN	FTAFLHPEEFEHMKEIVVLEtLEDIDKNGDGFVDQDEyIAD
Q15599	S298	Sugiyama	NHERF2 SLC9A3R2	PGsDKDtEDGSAWKQDPFQEsGLHLsPtAAEAKEKARAMRV
Q16513	S591	Sugiyama	PKN2 PRK2 PRKCL2	EPEPPPAPPRAssLGEIDEssELRVLDIPGQDsEtVFDIQN
Q16576	T10	Sugiyama	RBBP7 RBAP46	___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q27J81	S1192	Sugiyama	INF2 C14orf151 C14orf173	EDEDEEDtAPEsALDtsLDKsFsEDAVtDssGsGtLPRARG
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q53EL6	S48	Sugiyama	PDCD4 H731	EENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKNss
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1	T107	Sugiyama	ACTBL2	WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5JSH3	S71	Sugiyama	WDR44 RPH11	PVQELKQDVSKKIIEsIIEEsQKVLQLEDDsLDSKGKELsD
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VT52	S1177	Sugiyama	RPRD2 KIAA0460 HSPC099	GGLTGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPs
Q6PEY2	T73	Sugiyama	TUBA3E	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2	T80	Sugiyama	TUBA3E	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6PEY2	T82	Sugiyama	TUBA3E	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASN
Q6PEY2	Y83	Sugiyama	TUBA3E	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASNY
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6XUX3	S291	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	YFSFPVFFFKVPKLGSEIIDssTRRMESERSPLYRQLIDLG
Q6XUX3	S292	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	FSFPVFFFKVPKLGSEIIDssTRRMESERSPLYRQLIDLGY
Q6XUX3	S315	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	RMESERSPLYRQLIDLGYLSsSHWNCGAPGQDTKAQSMLVE
Q6XUX3	S337	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	HWNCGAPGQDTKAQSMLVEQsEKLRHLSTFSHQVLQTRLVD
Q6XUX3	S404	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	LQITPKRLEYTRKKENELYEsLMNIANRKQEEMKDMIVEtL
Q6XUX3	S483	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	QIQELIISRLNQAVANKLISsVDyLRESFVGtLERCLQSLE
Q6XUX3	S575	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	VSPPAITLEWKRKVAQEAIEsLsAsKLAKSICSQFRTRLNS
Q6XUX3	S577	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	PPAITLEWKRKVAQEAIEsLsAsKLAKSICSQFRTRLNSsH
Q6XUX3	S579	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	AITLEWKRKVAQEAIEsLsAsKLAKSICSQFRTRLNSsHEA
Q6XUX3	S58	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	LGRLRQNLRETQKFFRDIKCsHNHtCLssLtGGGGAERGPA
Q6XUX3	S596	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	LsAsKLAKSICSQFRTRLNSsHEAFAAsLRQLEAGHSGRLE
Q6XUX3	S603	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	KSICSQFRTRLNSsHEAFAAsLRQLEAGHSGRLEKtEDLWL
Q6XUX3	S65	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	LRETQKFFRDIKCsHNHtCLssLtGGGGAERGPAGDVAETG
Q6XUX3	S66	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	RETQKFFRDIKCsHNHtCLssLtGGGGAERGPAGDVAETGL
Q6XUX3	S770	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	TLETRLQIALDVVEGIRFLHsQGLVHRDIKLKNVLLDKQNR
Q6XUX3	T423	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	EsLMNIANRKQEEMKDMIVEtLNtMKEELLDDAtNMEFKDV
Q6XUX3	T426	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	MNIANRKQEEMKDMIVEtLNtMKEELLDDAtNMEFKDVIVP
Q6XUX3	T436	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	MKDMIVEtLNtMKEELLDDAtNMEFKDVIVPENGEPVGTRE
Q6XUX3	T494	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	QAVANKLISsVDyLRESFVGtLERCLQSLEKSQDVSVHITS
Q6XUX3	T618	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	EAFAAsLRQLEAGHSGRLEKtEDLWLRVRKDHAPRLARLSL
Q6XUX3	T62	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	RQNLRETQKFFRDIKCsHNHtCLssLtGGGGAERGPAGDVA
Q6XUX3	T68	Sugiyama	DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P	TQKFFRDIKCsHNHtCLssLtGGGGAERGPAGDVAETGLQA
Q6ZMR3	S167	Sugiyama	LDHAL6A LDHL2	AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	T82	Sugiyama	TUBA1A TUBA3	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7Z417	S655	Sugiyama	NUFIP2 KIAA1321 PIG1	LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q86U42	S235	Sugiyama	PABPN1 PAB2 PABP2	FAyIEFSDKEsVRTSLALDEsLFRGRQIKVIPKRTNRPGIS
Q86V48	S1042	Sugiyama	LUZP1	ASMEEEGEDCTLSVYRQLHNsLDPSELPGKQGLPESGRVRA
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q8N6H7	S368	Sugiyama	ARFGAP2 ZNF289 Nbla10535	VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8NBJ7	S264	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	AAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPDsAsD
Q8NBK3	S234	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	AVAYCTWAGKRLPTEAEWEYsCRGGLHNRLFPWGNKLQPKG
Q8NBS9	S426	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8NEF9	S264	Sugiyama	SRFBP1	SGNsDGGEEFCEEEKEYFDDstEERFYKQSsMSEDsDsGDD
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92769	S424	Sugiyama	HDAC2	KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK
Q92900	S1110	Sugiyama	UPF1 KIAA0221 RENT1	QDSYLGDEFKsQIDVALsQDstyQGERAyQHGGVtGLsQy_
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96CT7	S155	Sugiyama	CCDC124	RVLEEGsVEARTIEDAIAVLsVAEEAADRHPERRMRAAFTA
Q96CT7	T103	Sugiyama	CCDC124	GGKAPRVATSSKVTRAQIEDtLRRDHQLREAPDTAEKAKsH
Q96QK1	S760	Sugiyama	VPS35 MEM3 TCCCTA00141	IQVLNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLR
Q99497	S57	Sugiyama	PARK7	GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99613	S39	Sugiyama	EIF3C EIF3S8	GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613	S639	Sugiyama	EIF3C EIF3S8	CAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQERN
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99848	S269	Sugiyama	EBNA1BP2 EBP2	GFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGS
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3	T82	Sugiyama	TUBA1C TUBA6	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BR76	S391	Sugiyama	CORO1B	EAALEAEEWVSGRDADPILIsLREAYVPSKQRDLKISRRNV
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1	T107	Sugiyama	TUBB2B	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q9BX40	S349	Sugiyama	LSM14B C20orf40 FAM61B RAP55B	SSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGGRGNG
Q9BXS6	S363	Sugiyama	NUSAP1 ANKT BM-037 PRO0310	TtEAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQS
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZI7	S166	Sugiyama	UPF3B RENT3B UPF3X	KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9H1E3	S19	Sugiyama	NUCKS1 NUCKS JC7	__MSRPVRNRKVVDysQFQEsDDADEDyGRDsGPPtKKIRS
Q9H2U2	S313	Sugiyama	PPA2 HSPC124	VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H788	S124	Sugiyama	SH2D4A PPP1R38 SH2A	LKAEQEAEEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKD
Q9NTJ3	S466	Sugiyama	SMC4 CAPC SMC4L1	NNALEKEKEKEEKKLKEVMDsLKQETQGLQKEKESREKELM
Q9NW68	S17	Sugiyama	BSDC1 UNQ2494/PRO5781	____MAEGEDVGWWRSWLQQsYQAVKEKSSEALEFMKRDLT
Q9NYF8	S427	Sugiyama	BCLAF1 BTF KIAA0164	DyRQFRKsVLADQGKsFATAsHRNtEEEGLKyKSKVSLKGN
Q9UBC2	S518	Sugiyama	EPS15L1 EPS15R	LNRAKSELNRLQQEETQLEQsIQAGRVQLETIIKSLKSTQD
Q9UHI6	S678	Sugiyama	DDX20 DP103 GEMIN3	SySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLEQ
Q9UNF0	S273	Sugiyama	PACSIN2	KHLDLSNVAGYKAIyHDLEQsIRAADAVEDLRWFRANHGPG
Q9UNX3	S9	Sugiyama	RPL26L1 RPL26P1	____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UNZ2	S74	Sugiyama	NSFL1C UBXN2C	SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9UQE7	S886	Sugiyama	SMC3 BAM BMH CSPG6 SMC3L1	LEAINKRVKDTMARSEDLDNsIDKTEAGIKELQKSMERWKN
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7	T124	Sugiyama	YBX2 CSDA3 MSY2	RNGyGFINRNDtKEDVFVHQtAIKRNNPRKFLRsVGDGEtV
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2X3	S509	Sugiyama	NOP58 NOL5 NOP5 HSPC120	KRGKKKHIKEEPLsEEEPCtstAIAsPEKKKKKKKKRENED
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y5K6	S463	Sugiyama	CD2AP	SKLKLDsEQLPLRPKsVDFDsLtVRtsKEtDVVNFDDIASS
Q9Y5K6	T465	Sugiyama	CD2AP	LKLDsEQLPLRPKsVDFDsLtVRtsKEtDVVNFDDIASSEN
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	6.661338e-16	15.176
Mitotic Prometaphase	R-HSA-68877	2.611245e-13	12.583
Cell Cycle, Mitotic	R-HSA-69278	1.749267e-12	11.757
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.903000e-11	10.721
M Phase	R-HSA-68886	9.995860e-11	10.000
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.322785e-10	9.080
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.266788e-09	8.645
Signaling by ALK in cancer	R-HSA-9700206	2.266788e-09	8.645
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.402148e-09	8.468
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.140494e-09	8.383
G2/M Transition	R-HSA-69275	1.775385e-08	7.751
Mitotic G2-G2/M phases	R-HSA-453274	2.449937e-08	7.611
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.289552e-08	7.483
Mitotic Anaphase	R-HSA-68882	3.198625e-08	7.495
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.056667e-08	7.515
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.703002e-08	7.431
Membrane Trafficking	R-HSA-199991	3.724983e-08	7.429
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.075061e-08	7.042
Kinesins	R-HSA-983189	1.674704e-07	6.776
Separation of Sister Chromatids	R-HSA-2467813	1.843264e-07	6.734
Post NMDA receptor activation events	R-HSA-438064	2.014464e-07	6.696
Apoptotic execution phase	R-HSA-75153	4.121772e-07	6.385
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.825156e-07	6.316
Centrosome maturation	R-HSA-380287	7.789016e-07	6.109
COPI-mediated anterograde transport	R-HSA-6807878	7.604904e-07	6.119
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	7.304370e-07	6.136
AURKA Activation by TPX2	R-HSA-8854518	8.283723e-07	6.082
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.227382e-06	5.911
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.227382e-06	5.911
Golgi-to-ER retrograde transport	R-HSA-8856688	1.835325e-06	5.736
EPH-Ephrin signaling	R-HSA-2682334	2.053197e-06	5.688
Recycling pathway of L1	R-HSA-437239	1.983663e-06	5.703
Selective autophagy	R-HSA-9663891	2.036725e-06	5.691
Aggrephagy	R-HSA-9646399	2.305665e-06	5.637
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	4.596090e-06	5.338
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.521175e-06	5.258
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.073608e-06	5.217
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.240632e-06	5.205
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.777025e-06	5.169
Oncogenic MAPK signaling	R-HSA-6802957	6.740356e-06	5.171
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.707780e-06	5.173
Transport of connexons to the plasma membrane	R-HSA-190872	7.336517e-06	5.135
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.757859e-06	5.058
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.463532e-05	4.835
Signaling by RAS mutants	R-HSA-6802949	1.684458e-05	4.774
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.684458e-05	4.774
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.684458e-05	4.774
Signaling downstream of RAS mutants	R-HSA-9649948	1.684458e-05	4.774
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.085876e-05	4.681
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.259233e-05	4.487
Macroautophagy	R-HSA-1632852	4.035638e-05	4.394
L1CAM interactions	R-HSA-373760	4.102386e-05	4.387
Cell Cycle Checkpoints	R-HSA-69620	4.176804e-05	4.379
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.205761e-05	4.376
ER to Golgi Anterograde Transport	R-HSA-199977	4.753883e-05	4.323
Signaling by RAF1 mutants	R-HSA-9656223	4.812762e-05	4.318
Cilium Assembly	R-HSA-5617833	6.566196e-05	4.183
Autophagy	R-HSA-9612973	7.064721e-05	4.151
Post-chaperonin tubulin folding pathway	R-HSA-389977	7.656621e-05	4.116
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.869383e-05	4.052
Regulation of KIT signaling	R-HSA-1433559	9.271223e-05	4.033
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.075388e-04	3.968
Signaling by Hippo	R-HSA-2028269	1.057548e-04	3.976
DNA Double-Strand Break Repair	R-HSA-5693532	9.977989e-05	4.001
Chromatin organization	R-HSA-4839726	1.051153e-04	3.978
Gap junction trafficking and regulation	R-HSA-157858	1.057170e-04	3.976
Axon guidance	R-HSA-422475	1.099303e-04	3.959
Nervous system development	R-HSA-9675108	1.300250e-04	3.886
Signaling by ERBB2	R-HSA-1227986	1.339338e-04	3.873
Chromatin modifying enzymes	R-HSA-3247509	1.499160e-04	3.824
MAP2K and MAPK activation	R-HSA-5674135	1.502564e-04	3.823
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.730334e-04	3.762
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.771625e-04	3.752
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.229087e-04	3.652
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.370293e-04	3.625
SOS-mediated signalling	R-HSA-112412	2.639697e-04	3.578
Cohesin Loading onto Chromatin	R-HSA-2470946	2.639697e-04	3.578
EPHA-mediated growth cone collapse	R-HSA-3928663	2.673551e-04	3.573
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.903352e-04	3.537
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.940068e-04	3.532
Gap junction trafficking	R-HSA-190828	2.957338e-04	3.529
Vesicle-mediated transport	R-HSA-5653656	2.980301e-04	3.526
Amplification of signal from the kinetochores	R-HSA-141424	3.138649e-04	3.503
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.138649e-04	3.503
Mitotic Spindle Checkpoint	R-HSA-69618	3.281100e-04	3.484
Cellular response to heat stress	R-HSA-3371556	3.747161e-04	3.426
Cell-Cell communication	R-HSA-1500931	3.853530e-04	3.414
Signal Transduction	R-HSA-162582	3.961636e-04	3.402
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.977039e-04	3.400
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.366939e-04	3.360
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.637585e-04	3.334
MHC class II antigen presentation	R-HSA-2132295	4.780076e-04	3.321
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.503239e-04	3.259
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.861354e-04	3.232
Signaling by PDGFR in disease	R-HSA-9671555	5.861354e-04	3.232
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.921943e-04	3.228
Signaling by SCF-KIT	R-HSA-1433557	6.756522e-04	3.170
Signaling by VEGF	R-HSA-194138	6.801496e-04	3.167
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	7.623381e-04	3.118
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.689402e-04	3.114
ALK mutants bind TKIs	R-HSA-9700645	7.689402e-04	3.114
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.851633e-04	3.105
Signaling by KIT in disease	R-HSA-9669938	7.851633e-04	3.105
EPHB-mediated forward signaling	R-HSA-3928662	8.256015e-04	3.083
Organelle biogenesis and maintenance	R-HSA-1852241	8.343770e-04	3.079
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	9.210618e-04	3.036
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.936881e-04	3.049
Apoptosis	R-HSA-109581	9.757830e-04	3.011
FLT3 Signaling	R-HSA-9607240	1.015809e-03	2.993
mRNA Splicing - Major Pathway	R-HSA-72163	1.120042e-03	2.951
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.214511e-03	2.916
Regulation of MECP2 expression and activity	R-HSA-9022692	1.219592e-03	2.914
Nuclear Envelope Breakdown	R-HSA-2980766	1.313544e-03	2.882
DNA Repair	R-HSA-73894	1.271770e-03	2.896
PKR-mediated signaling	R-HSA-9833482	1.500578e-03	2.824
MECP2 regulates transcription factors	R-HSA-9022707	1.566245e-03	2.805
mRNA Splicing	R-HSA-72172	1.652265e-03	2.782
DAP12 signaling	R-HSA-2424491	1.844802e-03	2.734
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.844802e-03	2.734
Gap junction assembly	R-HSA-190861	1.880364e-03	2.726
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.075988e-03	2.683
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.336859e-03	2.631
Chaperone Mediated Autophagy	R-HSA-9613829	2.336859e-03	2.631
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.288638e-03	2.640
Nuclear Receptor transcription pathway	R-HSA-383280	2.483976e-03	2.605
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.508171e-03	2.601
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.508171e-03	2.601
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.583552e-03	2.588
HSF1-dependent transactivation	R-HSA-3371571	2.885002e-03	2.540
Signaling by EGFR	R-HSA-177929	2.679406e-03	2.572
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.895442e-03	2.538
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.895442e-03	2.538
Cell junction organization	R-HSA-446728	2.944179e-03	2.531
Regulation of CDH1 Function	R-HSA-9764561	3.124151e-03	2.505
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.199518e-03	2.495
Signaling by FGFR1 in disease	R-HSA-5655302	3.259759e-03	2.487
MITF-M-dependent gene expression	R-HSA-9856651	3.333295e-03	2.477
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.638988e-03	2.439
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.275630e-03	2.369
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.256657e-03	2.371
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.316270e-03	2.365
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.256657e-03	2.371
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.525152e-03	2.344
Regulation of TP53 Activity	R-HSA-5633007	4.541556e-03	2.343
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.673814e-03	2.330
SHC1 events in ERBB4 signaling	R-HSA-1250347	4.673814e-03	2.330
Programmed Cell Death	R-HSA-5357801	4.938983e-03	2.306
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.129360e-03	2.290
ATP-dependent chromatin remodelers	R-HSA-9932444	5.315039e-03	2.274
SWI/SNF chromatin remodelers	R-HSA-9932451	5.315039e-03	2.274
Long-term potentiation	R-HSA-9620244	5.315039e-03	2.274
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.113553e-03	2.214
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.113553e-03	2.214
Attenuation phase	R-HSA-3371568	5.800945e-03	2.237
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.152888e-03	2.211
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.282536e-03	2.202
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	6.361225e-03	2.196
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.500609e-03	2.187
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	6.539569e-03	2.184
Myogenesis	R-HSA-525793	6.568882e-03	2.183
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.065041e-03	2.151
Homology Directed Repair	R-HSA-5693538	7.188558e-03	2.143
HSF1 activation	R-HSA-3371511	7.331556e-03	2.135
Regulation of localization of FOXO transcription factors	R-HSA-9614399	7.886919e-03	2.103
Ephrin signaling	R-HSA-3928664	7.867185e-03	2.104
Notch-HLH transcription pathway	R-HSA-350054	8.122603e-03	2.090
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.867185e-03	2.104
MITF-M-regulated melanocyte development	R-HSA-9730414	8.636432e-03	2.064
PECAM1 interactions	R-HSA-210990	7.886919e-03	2.103
Transcriptional Regulation by TP53	R-HSA-3700989	8.849494e-03	2.053
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	9.272058e-03	2.033
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.272058e-03	2.033
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.272058e-03	2.033
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.358001e-03	2.029
Erythropoietin activates RAS	R-HSA-9027284	9.358001e-03	2.029
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.358001e-03	2.029
Cell-extracellular matrix interactions	R-HSA-446353	9.358001e-03	2.029
Transport to the Golgi and subsequent modification	R-HSA-948021	9.570779e-03	2.019
G2/M Checkpoints	R-HSA-69481	9.902878e-03	2.004
Impaired BRCA2 binding to PALB2	R-HSA-9709603	9.973831e-03	2.001
Resolution of D-Loop Structures	R-HSA-5693537	1.101694e-02	1.958
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.102787e-02	1.958
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.210592e-02	1.917
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.247269e-02	1.904
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.247269e-02	1.904
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.247269e-02	1.904
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.247269e-02	1.904
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.247269e-02	1.904
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.173283e-02	1.931
RAF activation	R-HSA-5673000	1.300244e-02	1.886
Signaling by MET	R-HSA-6806834	1.305399e-02	1.884
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.323560e-02	1.878
Signaling by RAS GAP mutants	R-HSA-9753510	1.323560e-02	1.878
G2/M DNA damage checkpoint	R-HSA-69473	1.324681e-02	1.878
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.400026e-02	1.854
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.507075e-02	1.822
Signaling by PTK6	R-HSA-8848021	1.507075e-02	1.822
Signalling to ERKs	R-HSA-187687	1.524799e-02	1.817
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.540242e-02	1.812
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.540242e-02	1.812
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.713200e-02	1.766
Lipophagy	R-HSA-9613354	1.644706e-02	1.784
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.875390e-02	1.727
Formation of RNA Pol II elongation complex	R-HSA-112382	1.690888e-02	1.772
Nucleotide Excision Repair	R-HSA-5696398	1.856969e-02	1.731
GP1b-IX-V activation signalling	R-HSA-430116	1.644706e-02	1.784
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.781591e-02	1.749
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.644706e-02	1.784
Intra-Golgi traffic	R-HSA-6811438	1.853911e-02	1.732
Adherens junctions interactions	R-HSA-418990	1.822285e-02	1.739
Unwinding of DNA	R-HSA-176974	1.644706e-02	1.784
FLT3 signaling in disease	R-HSA-9682385	1.777295e-02	1.750
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.875390e-02	1.727
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.658029e-02	1.780
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.713200e-02	1.766
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.897044e-02	1.722
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.911009e-02	1.719
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.914110e-02	1.718
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.926081e-02	1.715
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.059640e-02	1.686
Cellular Senescence	R-HSA-2559583	2.110089e-02	1.676
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.118804e-02	1.674
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.118804e-02	1.674
Regulation of PTEN gene transcription	R-HSA-8943724	2.142711e-02	1.669
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.501117e-02	1.602
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.501117e-02	1.602
Diseases of Telomere Maintenance	R-HSA-9673013	2.501117e-02	1.602
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.501117e-02	1.602
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.501117e-02	1.602
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.501117e-02	1.602
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.366922e-02	1.626
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.500135e-02	1.602
MET activates RAP1 and RAC1	R-HSA-8875555	2.228033e-02	1.652
2-LTR circle formation	R-HSA-164843	2.228033e-02	1.652
HIV elongation arrest and recovery	R-HSA-167287	2.499596e-02	1.602
Pausing and recovery of HIV elongation	R-HSA-167290	2.499596e-02	1.602
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.279204e-02	1.642
Nef and signal transduction	R-HSA-164944	2.500135e-02	1.602
Regulation of CDH11 function	R-HSA-9762292	2.228033e-02	1.652
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.348875e-02	1.629
Estrogen-dependent gene expression	R-HSA-9018519	2.344879e-02	1.630
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.277077e-02	1.643
Cell-cell junction organization	R-HSA-421270	2.409877e-02	1.618
Death Receptor Signaling	R-HSA-73887	2.148703e-02	1.668
Signal regulatory protein family interactions	R-HSA-391160	2.393572e-02	1.621
Intraflagellar transport	R-HSA-5620924	2.155018e-02	1.667
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.277077e-02	1.643
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.277077e-02	1.643
EGFR Transactivation by Gastrin	R-HSA-2179392	2.228033e-02	1.652
Signaling by FGFR4 in disease	R-HSA-5655291	2.393572e-02	1.621
Signaling by ERBB4	R-HSA-1236394	2.533480e-02	1.596
Mitotic Prophase	R-HSA-68875	2.537715e-02	1.596
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.642575e-02	1.578
Striated Muscle Contraction	R-HSA-390522	2.642575e-02	1.578
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.721262e-02	1.565
DAP12 interactions	R-HSA-2172127	2.752303e-02	1.560
Chaperonin-mediated protein folding	R-HSA-390466	2.843368e-02	1.546
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.926545e-02	1.534
Activated NTRK3 signals through RAS	R-HSA-9034864	2.931085e-02	1.533
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.999720e-02	1.523
p38MAPK events	R-HSA-171007	2.999720e-02	1.523
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.999720e-02	1.523
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.999720e-02	1.523
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.999720e-02	1.523
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.999720e-02	1.523
Cellular responses to stress	R-HSA-2262752	3.090201e-02	1.510
Nuclear signaling by ERBB4	R-HSA-1251985	3.104060e-02	1.508
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.104060e-02	1.508
HIV Transcription Elongation	R-HSA-167169	3.104060e-02	1.508
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.104060e-02	1.508
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.104060e-02	1.508
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.112227e-02	1.507
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.182728e-02	1.497
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.747130e-02	1.426
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	3.747130e-02	1.426
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	3.747130e-02	1.426
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	3.747130e-02	1.426
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.473277e-02	1.459
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.473277e-02	1.459
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.775561e-02	1.423
Activation of the pre-replicative complex	R-HSA-68962	3.402035e-02	1.468
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.537885e-02	1.451
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.523712e-02	1.453
Integration of provirus	R-HSA-162592	3.760030e-02	1.425
FLT3 signaling through SRC family kinases	R-HSA-9706374	3.747130e-02	1.426
Cation-coupled Chloride cotransporters	R-HSA-426117	3.473277e-02	1.459
Activated NTRK2 signals through RAS	R-HSA-9026519	3.760030e-02	1.425
Downregulation of ERBB2 signaling	R-HSA-8863795	3.402035e-02	1.468
PKMTs methylate histone lysines	R-HSA-3214841	3.523712e-02	1.453
Smooth Muscle Contraction	R-HSA-445355	3.849619e-02	1.415
Interleukin-37 signaling	R-HSA-9008059	3.402035e-02	1.468
Regulation of TP53 Degradation	R-HSA-6804757	3.987349e-02	1.399
Cellular responses to stimuli	R-HSA-8953897	4.069286e-02	1.390
Signalling to RAS	R-HSA-167044	4.151765e-02	1.382
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.195648e-02	1.377
DNA Double Strand Break Response	R-HSA-5693606	4.395717e-02	1.357
Signaling by EGFR in Cancer	R-HSA-1643713	4.397969e-02	1.357
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.397969e-02	1.357
MTOR signalling	R-HSA-165159	4.479498e-02	1.349
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.479498e-02	1.349
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	4.524288e-02	1.344
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.555734e-02	1.341
Signaling by FGFR in disease	R-HSA-1226099	4.608383e-02	1.336
Type I hemidesmosome assembly	R-HSA-446107	4.637253e-02	1.334
Downregulation of ERBB4 signaling	R-HSA-1253288	4.637253e-02	1.334
Signaling by MRAS-complex mutants	R-HSA-9660537	4.637253e-02	1.334
Formation of annular gap junctions	R-HSA-196025	4.637253e-02	1.334
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.637253e-02	1.334
Activation of RAS in B cells	R-HSA-1169092	4.637253e-02	1.334
Protein folding	R-HSA-391251	4.686531e-02	1.329
Epigenetic regulation of gene expression	R-HSA-212165	4.712777e-02	1.327
GRB2 events in EGFR signaling	R-HSA-179812	4.718984e-02	1.326
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.718984e-02	1.326
MET activates RAS signaling	R-HSA-8851805	4.718984e-02	1.326
SHC-related events triggered by IGF1R	R-HSA-2428933	4.718984e-02	1.326
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.718984e-02	1.326
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.775926e-02	1.321
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.893832e-02	1.310
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.893832e-02	1.310
ESR-mediated signaling	R-HSA-8939211	4.999436e-02	1.301
ISG15 antiviral mechanism	R-HSA-1169408	5.025930e-02	1.299
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.084344e-02	1.294
Interaction between L1 and Ankyrins	R-HSA-445095	5.084344e-02	1.294
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.084344e-02	1.294
MET promotes cell motility	R-HSA-8875878	5.108081e-02	1.292
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.140148e-02	1.289
FGFR1 mutant receptor activation	R-HSA-1839124	5.140148e-02	1.289
p75 NTR receptor-mediated signalling	R-HSA-193704	5.163807e-02	1.287
TRAF3 deficiency - HSE	R-HSA-5602571	5.202009e-02	1.284
Breakdown of the nuclear lamina	R-HSA-352238	5.202009e-02	1.284
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.454761e-02	1.263
ARMS-mediated activation	R-HSA-170984	5.992033e-02	1.222
Gap junction degradation	R-HSA-190873	5.992033e-02	1.222
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.810005e-02	1.236
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.387284e-02	1.269
Signaling by Erythropoietin	R-HSA-9006335	6.654841e-02	1.177
Signaling by CSF3 (G-CSF)	R-HSA-9674555	6.654841e-02	1.177
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.574281e-02	1.182
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.574281e-02	1.182
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.739937e-02	1.241
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.420839e-02	1.192
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.420839e-02	1.192
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.420839e-02	1.192
Semaphorin interactions	R-HSA-373755	5.515351e-02	1.258
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.616487e-02	1.179
Meiosis	R-HSA-1500620	6.578256e-02	1.182
Nuclear import of Rev protein	R-HSA-180746	6.574281e-02	1.182
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.739937e-02	1.241
Interactions of Rev with host cellular proteins	R-HSA-177243	6.420839e-02	1.192
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	5.992033e-02	1.222
Signaling by ALK	R-HSA-201556	5.739937e-02	1.241
Signaling by NTRKs	R-HSA-166520	5.444652e-02	1.264
S Phase	R-HSA-69242	5.444652e-02	1.264
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.616487e-02	1.179
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.381333e-02	1.195
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.584413e-02	1.181
Transcriptional Regulation by MECP2	R-HSA-8986944	6.689934e-02	1.175
Metabolism of non-coding RNA	R-HSA-194441	6.920944e-02	1.160
snRNP Assembly	R-HSA-191859	6.920944e-02	1.160
Meiotic synapsis	R-HSA-1221632	7.262251e-02	1.139
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.377106e-02	1.132
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.377106e-02	1.132
Aryl hydrocarbon receptor signalling	R-HSA-8937144	7.468930e-02	1.127
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	7.468930e-02	1.127
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	7.468930e-02	1.127
Regulation of signaling by CBL	R-HSA-912631	7.476009e-02	1.126
Specification of the neural plate border	R-HSA-9834899	7.476009e-02	1.126
The NLRP3 inflammasome	R-HSA-844456	7.476009e-02	1.126
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.476009e-02	1.126
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.533452e-02	1.123
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	7.533452e-02	1.123
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.533452e-02	1.123
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.540773e-02	1.123
Activation of BH3-only proteins	R-HSA-114452	7.540773e-02	1.123
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.554824e-02	1.122
Neurodegenerative Diseases	R-HSA-8863678	7.598889e-02	1.119
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.598889e-02	1.119
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.958717e-02	1.099
Transcriptional regulation by RUNX1	R-HSA-8878171	8.155622e-02	1.089
Interleukin-12 family signaling	R-HSA-447115	8.187049e-02	1.087
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.386655e-02	1.076
DCC mediated attractive signaling	R-HSA-418885	8.386655e-02	1.076
SHC1 events in EGFR signaling	R-HSA-180336	8.386655e-02	1.076
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.494278e-02	1.071
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.494278e-02	1.071
Downstream signal transduction	R-HSA-186763	8.494278e-02	1.071
HIV Infection	R-HSA-162906	8.512272e-02	1.070
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.556014e-02	1.068
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.556014e-02	1.068
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.556014e-02	1.068
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.556014e-02	1.068
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.586908e-02	1.066
Interferon Signaling	R-HSA-913531	8.621088e-02	1.064
Sema4D in semaphorin signaling	R-HSA-400685	8.662097e-02	1.062
Interleukin-7 signaling	R-HSA-1266695	8.662097e-02	1.062
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.670623e-02	1.062
Co-inhibition by CTLA4	R-HSA-389513	8.670623e-02	1.062
SARS-CoV-1-host interactions	R-HSA-9692914	8.848599e-02	1.053
HIV Life Cycle	R-HSA-162587	8.864622e-02	1.052
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.931578e-02	1.049
NCAM signaling for neurite out-growth	R-HSA-375165	8.931578e-02	1.049
Clathrin-mediated endocytosis	R-HSA-8856828	9.045176e-02	1.044
Defective F9 secretion	R-HSA-9673218	1.141090e-01	0.943
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.141090e-01	0.943
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.141090e-01	0.943
Autointegration results in viral DNA circles	R-HSA-177539	9.761080e-02	1.011
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.229793e-01	0.910
RUNX3 regulates WNT signaling	R-HSA-8951430	1.229793e-01	0.910
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.229793e-01	0.910
TRIF-mediated programmed cell death	R-HSA-2562578	1.229793e-01	0.910
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.114246e-01	0.953
Disorders of Developmental Biology	R-HSA-9675151	1.146895e-01	0.940
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.135192e-01	0.945
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	9.805351e-02	1.009
IPs transport between nucleus and cytosol	R-HSA-1855170	1.060264e-01	0.975
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.060264e-01	0.975
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.175571e-01	0.930
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.116586e-01	0.952
Nucleosome assembly	R-HSA-774815	1.156157e-01	0.937
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.156157e-01	0.937
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.457104e-02	1.024
Transcriptional regulation by RUNX3	R-HSA-8878159	1.135263e-01	0.945
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.057903e-01	0.976
Integrin signaling	R-HSA-354192	1.060264e-01	0.975
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.175571e-01	0.930
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.156157e-01	0.937
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	9.963475e-02	1.002
Interleukin-2 family signaling	R-HSA-451927	1.225538e-01	0.912
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.136254e-01	0.945
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.146895e-01	0.940
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.013254e-01	0.994
Neurexins and neuroligins	R-HSA-6794361	1.183419e-01	0.927
Host Interactions of HIV factors	R-HSA-162909	1.224007e-01	0.912
Deubiquitination	R-HSA-5688426	1.072165e-01	0.970
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.102726e-01	0.958
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.135192e-01	0.945
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.013254e-01	0.994
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.175571e-01	0.930
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.674843e-02	1.014
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.217866e-01	0.914
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.457104e-02	1.024
Integration of viral DNA into host genomic DNA	R-HSA-175567	9.761080e-02	1.011
Early Phase of HIV Life Cycle	R-HSA-162594	9.963475e-02	1.002
Activation of ATR in response to replication stress	R-HSA-176187	1.060264e-01	0.975
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.135192e-01	0.945
Interleukin-12 signaling	R-HSA-9020591	9.245870e-02	1.034
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.232583e-01	0.909
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.232583e-01	0.909
Formation of the Early Elongation Complex	R-HSA-113418	1.232583e-01	0.909
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	1.237906e-01	0.907
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.237906e-01	0.907
MET activates PTPN11	R-HSA-8865999	1.237906e-01	0.907
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.237906e-01	0.907
Cytokine Signaling in Immune system	R-HSA-1280215	1.250321e-01	0.903
Regulation of TNFR1 signaling	R-HSA-5357905	1.259332e-01	0.900
HATs acetylate histones	R-HSA-3214847	1.276703e-01	0.894
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.281359e-01	0.892
mTORC1-mediated signalling	R-HSA-166208	1.283242e-01	0.892
Processing of DNA double-strand break ends	R-HSA-5693607	1.300321e-01	0.886
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.318645e-01	0.880
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.318645e-01	0.880
RUNX3 regulates p14-ARF	R-HSA-8951936	1.318645e-01	0.880
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.318645e-01	0.880
Disorders of Nervous System Development	R-HSA-9697154	1.318645e-01	0.880
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.318645e-01	0.880
Pervasive developmental disorders	R-HSA-9005895	1.318645e-01	0.880
Interleukin-15 signaling	R-HSA-8983432	1.318645e-01	0.880
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.384613e-01	0.859
HCMV Early Events	R-HSA-9609690	1.418102e-01	0.848
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.425199e-01	0.846
MAPK family signaling cascades	R-HSA-5683057	1.434341e-01	0.843
Growth hormone receptor signaling	R-HSA-982772	1.440069e-01	0.842
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.440948e-01	0.841
PTEN Regulation	R-HSA-6807070	1.443929e-01	0.840
Gene expression (Transcription)	R-HSA-74160	1.449687e-01	0.839
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.486854e-01	0.828
HDACs deacetylate histones	R-HSA-3214815	1.490056e-01	0.827
Heme signaling	R-HSA-9707616	1.492584e-01	0.826
GAB1 signalosome	R-HSA-180292	1.501124e-01	0.824
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.501124e-01	0.824
Tie2 Signaling	R-HSA-210993	1.501124e-01	0.824
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.504374e-01	0.823
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.514218e-01	0.820
CD28 dependent Vav1 pathway	R-HSA-389359	1.537105e-01	0.813
Platelet Adhesion to exposed collagen	R-HSA-75892	1.537105e-01	0.813
Intracellular signaling by second messengers	R-HSA-9006925	1.551827e-01	0.809
RUNX2 regulates bone development	R-HSA-8941326	1.559098e-01	0.807
GPVI-mediated activation cascade	R-HSA-114604	1.559098e-01	0.807
RAF/MAP kinase cascade	R-HSA-5673001	1.583068e-01	0.801
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.584781e-01	0.800
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.597330e-01	0.797
Degradation of CDH1	R-HSA-9766229	1.597330e-01	0.797
TNF signaling	R-HSA-75893	1.600608e-01	0.796
NRAGE signals death through JNK	R-HSA-193648	1.600608e-01	0.796
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.605170e-01	0.794
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	1.605170e-01	0.794
Metabolism of RNA	R-HSA-8953854	1.614451e-01	0.792
Regulation of gap junction activity	R-HSA-191650	1.652055e-01	0.782
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.652055e-01	0.782
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.652055e-01	0.782
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.652055e-01	0.782
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.652055e-01	0.782
NADE modulates death signalling	R-HSA-205025	1.652055e-01	0.782
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.652055e-01	0.782
Protein-protein interactions at synapses	R-HSA-6794362	1.655113e-01	0.781
EGFR downregulation	R-HSA-182971	1.665334e-01	0.778
Trafficking of AMPA receptors	R-HSA-399719	1.665334e-01	0.778
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.152030e-01	0.667
Hereditary fructose intolerance	R-HSA-5657560	2.152030e-01	0.667
TICAM1 deficiency - HSE	R-HSA-5602566	2.152030e-01	0.667
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	2.152030e-01	0.667
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.152030e-01	0.667
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.152030e-01	0.667
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.152030e-01	0.667
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	2.152030e-01	0.667
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.152030e-01	0.667
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.085812e-01	0.681
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.085812e-01	0.681
NrCAM interactions	R-HSA-447038	2.085812e-01	0.681
IRS activation	R-HSA-74713	2.085812e-01	0.681
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.085812e-01	0.681
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.085812e-01	0.681
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.085812e-01	0.681
Defective F9 activation	R-HSA-9673221	2.085812e-01	0.681
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.796206e-01	0.746
CLEC7A/inflammasome pathway	R-HSA-5660668	2.529316e-01	0.597
Noncanonical activation of NOTCH3	R-HSA-9017802	2.529316e-01	0.597
IkBA variant leads to EDA-ID	R-HSA-5603029	2.529316e-01	0.597
Receptor Mediated Mitophagy	R-HSA-8934903	2.101698e-01	0.677
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.101698e-01	0.677
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.417406e-01	0.617
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.417406e-01	0.617
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.417406e-01	0.617
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.009745e-01	0.697
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.009745e-01	0.697
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.693540e-01	0.771
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.894945e-01	0.722
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.260544e-01	0.646
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.518718e-01	0.599
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.518718e-01	0.599
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.957904e-01	0.708
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.320759e-01	0.634
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.320759e-01	0.634
Regulation of RAS by GAPs	R-HSA-5658442	1.719026e-01	0.765
Dual Incision in GG-NER	R-HSA-5696400	2.328826e-01	0.633
Dual incision in TC-NER	R-HSA-6782135	1.833484e-01	0.737
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.797295e-01	0.745
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.906256e-01	0.720
Regulation of RUNX2 expression and activity	R-HSA-8939902	2.209868e-01	0.656
Transcription of the HIV genome	R-HSA-167172	2.171925e-01	0.663
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.518718e-01	0.599
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.768029e-01	0.753
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.148782e-01	0.668
Oncogene Induced Senescence	R-HSA-2559585	2.507086e-01	0.601
Co-stimulation by CD28	R-HSA-389356	2.430494e-01	0.614
TGFBR3 expression	R-HSA-9839394	1.777985e-01	0.750
Interleukin-2 signaling	R-HSA-9020558	2.417406e-01	0.617
Spry regulation of FGF signaling	R-HSA-1295596	2.009745e-01	0.697
Signal attenuation	R-HSA-74749	2.101698e-01	0.677
Rap1 signalling	R-HSA-392517	1.693540e-01	0.771
Generation of second messenger molecules	R-HSA-202433	2.148782e-01	0.668
FCGR3A-mediated phagocytosis	R-HSA-9664422	2.073414e-01	0.683
Leishmania phagocytosis	R-HSA-9664417	2.073414e-01	0.683
Parasite infection	R-HSA-9664407	2.073414e-01	0.683
Interleukin-27 signaling	R-HSA-9020956	2.101698e-01	0.677
MAPK1/MAPK3 signaling	R-HSA-5684996	1.952306e-01	0.709
PIP3 activates AKT signaling	R-HSA-1257604	1.896919e-01	0.722
Protein ubiquitination	R-HSA-8852135	2.133060e-01	0.671
Rab regulation of trafficking	R-HSA-9007101	1.780154e-01	0.750
Prolonged ERK activation events	R-HSA-169893	2.260544e-01	0.646
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.529316e-01	0.597
Negative regulation of MET activity	R-HSA-6807004	1.894945e-01	0.722
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.518718e-01	0.599
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.009745e-01	0.697
Diseases of Immune System	R-HSA-5260271	2.148782e-01	0.668
Diseases associated with the TLR signaling cascade	R-HSA-5602358	2.148782e-01	0.668
Signaling by FGFR4	R-HSA-5654743	1.714737e-01	0.766
Signaling by FGFR3	R-HSA-5654741	1.988645e-01	0.701
Formation of editosomes by ADAR proteins	R-HSA-77042	2.152030e-01	0.667
Co-inhibition by BTLA	R-HSA-9927353	2.085812e-01	0.681
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.009745e-01	0.697
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.009745e-01	0.697
Negative regulation of FLT3	R-HSA-9706369	2.260544e-01	0.646
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.104358e-01	0.677
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.320759e-01	0.634
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.133060e-01	0.671
HDMs demethylate histones	R-HSA-3214842	1.777985e-01	0.750
Negative regulation of MAPK pathway	R-HSA-5675221	2.471340e-01	0.607
CD163 mediating an anti-inflammatory response	R-HSA-9662834	2.417406e-01	0.617
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.699583e-01	0.770
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.691454e-01	0.772
Regulation of CDH11 gene transcription	R-HSA-9762293	1.796206e-01	0.746
Inflammasomes	R-HSA-622312	2.336418e-01	0.631
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.423304e-01	0.616
DNA strand elongation	R-HSA-69190	1.822800e-01	0.739
SARS-CoV-2-host interactions	R-HSA-9705683	2.035515e-01	0.691
Signaling by Leptin	R-HSA-2586552	2.101698e-01	0.677
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.085812e-01	0.681
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.320759e-01	0.634
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.986185e-01	0.702
Potential therapeutics for SARS	R-HSA-9679191	2.358492e-01	0.627
Hedgehog 'off' state	R-HSA-5610787	1.976679e-01	0.704
Diseases of DNA repair	R-HSA-9675135	2.132081e-01	0.671
Signaling by PDGF	R-HSA-186797	2.341828e-01	0.630
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.518718e-01	0.599
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.308060e-01	0.637
Signaling by FGFR3 in disease	R-HSA-5655332	2.144275e-01	0.669
XBP1(S) activates chaperone genes	R-HSA-381038	1.849527e-01	0.733
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.777985e-01	0.750
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.993890e-01	0.700
IRE1alpha activates chaperones	R-HSA-381070	2.493007e-01	0.603
Adaptive Immune System	R-HSA-1280218	2.530020e-01	0.597
Ribosomal scanning and start codon recognition	R-HSA-72702	2.530726e-01	0.597
Late endosomal microautophagy	R-HSA-9615710	2.533627e-01	0.596
Downstream signaling of activated FGFR3	R-HSA-5654708	2.533627e-01	0.596
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.543109e-01	0.595
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.552938e-01	0.593
NoRC negatively regulates rRNA expression	R-HSA-427413	2.552938e-01	0.593
Signaling by TGFB family members	R-HSA-9006936	2.557521e-01	0.592
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.563665e-01	0.591
DNA Damage Bypass	R-HSA-73893	2.584859e-01	0.588
RNA Polymerase II Transcription	R-HSA-73857	2.593755e-01	0.586
SARS-CoV-1 Infection	R-HSA-9678108	2.603012e-01	0.585
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.047658e-01	0.516
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-5619099	3.047658e-01	0.516
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.047658e-01	0.516
Defective SLC17A5 causes Salla disease (SD) and ISSD	R-HSA-5619035	3.047658e-01	0.516
XAV939 stabilizes AXIN	R-HSA-5545619	3.047658e-01	0.516
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.047658e-01	0.516
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.841122e-01	0.416
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.841122e-01	0.416
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.841122e-01	0.416
Defective factor IX causes thrombophilia	R-HSA-9672383	3.841122e-01	0.416
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.841122e-01	0.416
Defective cofactor function of FVIIIa variant	R-HSA-9672396	3.841122e-01	0.416
Defective F9 variant does not activate FX	R-HSA-9673202	3.841122e-01	0.416
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.841122e-01	0.416
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.974699e-01	0.527
CREB phosphorylation	R-HSA-199920	2.974699e-01	0.527
STAT5 Activation	R-HSA-9645135	2.974699e-01	0.527
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.974699e-01	0.527
Erythropoietin activates STAT5	R-HSA-9027283	2.974699e-01	0.527
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.740100e-01	0.562
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.740100e-01	0.562
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.740100e-01	0.562
MET activates PI3K/AKT signaling	R-HSA-8851907	3.415761e-01	0.467
IFNG signaling activates MAPKs	R-HSA-9732724	3.415761e-01	0.467
Recycling of eIF2:GDP	R-HSA-72731	3.415761e-01	0.467
MET activates STAT3	R-HSA-8875791	4.544069e-01	0.343
Axonal growth stimulation	R-HSA-209563	4.544069e-01	0.343
Defective gamma-carboxylation of F9	R-HSA-9673240	4.544069e-01	0.343
Signalling to STAT3	R-HSA-198745	4.544069e-01	0.343
3-Methylcrotonyl-CoA carboxylase deficiency	R-HSA-9909438	4.544069e-01	0.343
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.544069e-01	0.343
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.544069e-01	0.343
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.544069e-01	0.343
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.544069e-01	0.343
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.544069e-01	0.343
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.066800e-01	0.513
Repression of WNT target genes	R-HSA-4641265	3.066800e-01	0.513
Activated NTRK2 signals through FYN	R-HSA-9032500	3.847690e-01	0.415
Regulation by c-FLIP	R-HSA-3371378	3.847690e-01	0.415
Dimerization of procaspase-8	R-HSA-69416	3.847690e-01	0.415
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.847690e-01	0.415
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.847690e-01	0.415
MET receptor recycling	R-HSA-8875656	3.847690e-01	0.415
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.847690e-01	0.415
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	3.394805e-01	0.469
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.050540e-01	0.516
Interleukin receptor SHC signaling	R-HSA-912526	2.770365e-01	0.557
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.770365e-01	0.557
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.770365e-01	0.557
Translesion Synthesis by POLH	R-HSA-110320	3.321017e-01	0.479
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	3.721703e-01	0.429
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.266828e-01	0.370
Interleukin-21 signaling	R-HSA-9020958	4.266828e-01	0.370
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.266828e-01	0.370
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.266828e-01	0.370
CASP8 activity is inhibited	R-HSA-5218900	4.266828e-01	0.370
Alternative complement activation	R-HSA-173736	5.166821e-01	0.287
Nucleotide catabolism defects	R-HSA-9735786	5.166821e-01	0.287
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	5.166821e-01	0.287
Defective LFNG causes SCDO3	R-HSA-5083630	5.166821e-01	0.287
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.166821e-01	0.287
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.166821e-01	0.287
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.592563e-01	0.445
VxPx cargo-targeting to cilium	R-HSA-5620916	3.592563e-01	0.445
Diseases of mitotic cell cycle	R-HSA-9675126	3.148476e-01	0.502
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.045370e-01	0.393
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.863820e-01	0.413
Regulation of the apoptosome activity	R-HSA-9627069	4.670470e-01	0.331
Defective factor IX causes hemophilia B	R-HSA-9668250	4.670470e-01	0.331
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.670470e-01	0.331
Folding of actin by CCT/TriC	R-HSA-390450	4.670470e-01	0.331
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.826729e-01	0.549
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.570583e-01	0.447
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	4.363964e-01	0.360
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.363964e-01	0.360
Phosphorylation of the APC/C	R-HSA-176412	4.363964e-01	0.360
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.896654e-01	0.538
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.333552e-01	0.477
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.131955e-01	0.504
Translation initiation complex formation	R-HSA-72649	3.395199e-01	0.469
Transcriptional regulation by RUNX2	R-HSA-8878166	2.665160e-01	0.574
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.180925e-01	0.379
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.400579e-01	0.356
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.675916e-01	0.330
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.056694e-01	0.296
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.710412e-01	0.567
RET signaling	R-HSA-8853659	4.208441e-01	0.376
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	2.840774e-01	0.547
Transcriptional regulation by small RNAs	R-HSA-5578749	3.784676e-01	0.422
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.414419e-01	0.355
mRNA 3'-end processing	R-HSA-72187	4.414419e-01	0.355
TRAF6 mediated NF-kB activation	R-HSA-933542	4.922655e-01	0.308
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.593924e-01	0.338
mRNA Splicing - Minor Pathway	R-HSA-72165	4.803024e-01	0.318
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.803024e-01	0.318
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.042465e-01	0.297
Neutrophil degranulation	R-HSA-6798695	3.581489e-01	0.446
Regulation of endogenous retroelements	R-HSA-9842860	3.967138e-01	0.402
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.244608e-01	0.280
G0 and Early G1	R-HSA-1538133	4.876472e-01	0.312
Chromosome Maintenance	R-HSA-73886	2.872471e-01	0.542
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.967053e-01	0.402
mRNA Capping	R-HSA-72086	4.180925e-01	0.379
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.415327e-01	0.355
Formation of apoptosome	R-HSA-111458	4.670470e-01	0.331
Polo-like kinase mediated events	R-HSA-156711	3.050540e-01	0.516
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.629609e-01	0.334
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.415327e-01	0.355
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.244608e-01	0.280
Adipogenesis	R-HSA-9843745	4.199102e-01	0.377
Nephrin family interactions	R-HSA-373753	3.592563e-01	0.445
Metalloprotease DUBs	R-HSA-5689901	3.471325e-01	0.460
IRS-related events triggered by IGF1R	R-HSA-2428928	3.287330e-01	0.483
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.069487e-01	0.390
Regulation of necroptotic cell death	R-HSA-5675482	3.358776e-01	0.474
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.415761e-01	0.467
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.415761e-01	0.467
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.782592e-01	0.556
Interleukin-6 signaling	R-HSA-1059683	3.394805e-01	0.469
PI3K/AKT activation	R-HSA-198203	4.670470e-01	0.331
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.524747e-01	0.344
IRS-mediated signalling	R-HSA-112399	2.677437e-01	0.572
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.847690e-01	0.415
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.770365e-01	0.557
FOXO-mediated transcription	R-HSA-9614085	3.584181e-01	0.446
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.064702e-01	0.514
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.471325e-01	0.460
Fanconi Anemia Pathway	R-HSA-6783310	3.156388e-01	0.501
Stabilization of p53	R-HSA-69541	4.837319e-01	0.315
UCH proteinases	R-HSA-5689603	3.233006e-01	0.490
Mitochondrial biogenesis	R-HSA-1592230	5.208263e-01	0.283
Insulin receptor signalling cascade	R-HSA-74751	3.761115e-01	0.425
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.142326e-01	0.289
PI3K events in ERBB2 signaling	R-HSA-1963642	2.782592e-01	0.556
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.863820e-01	0.413
IGF1R signaling cascade	R-HSA-2428924	3.761115e-01	0.425
MyD88-independent TLR4 cascade	R-HSA-166166	4.094259e-01	0.388
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.670470e-01	0.331
Deadenylation-dependent mRNA decay	R-HSA-429914	4.238912e-01	0.373
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.094259e-01	0.388
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.477950e-01	0.459
Interleukin-9 signaling	R-HSA-8985947	3.847690e-01	0.415
Extra-nuclear estrogen signaling	R-HSA-9009391	4.895440e-01	0.310
Generic Transcription Pathway	R-HSA-212436	2.708064e-01	0.567
Late Phase of HIV Life Cycle	R-HSA-162599	3.045924e-01	0.516
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	3.047658e-01	0.516
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.740100e-01	0.562
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.415761e-01	0.467
PTK6 Expression	R-HSA-8849473	3.415761e-01	0.467
Adrenoceptors	R-HSA-390696	3.847690e-01	0.415
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.721703e-01	0.429
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.745458e-01	0.561
Formation of the posterior neural plate	R-HSA-9832991	5.056694e-01	0.296
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.979908e-01	0.303
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.762519e-01	0.425
Tight junction interactions	R-HSA-420029	5.175985e-01	0.286
Interleukin-35 Signalling	R-HSA-8984722	3.066800e-01	0.513
Signaling by NOTCH4	R-HSA-9013694	4.087975e-01	0.388
Signaling by NOTCH3	R-HSA-9012852	4.949198e-01	0.305
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.920664e-01	0.407
Circadian clock	R-HSA-9909396	5.253159e-01	0.280
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.131955e-01	0.504
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.131955e-01	0.504
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.131955e-01	0.504
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.131955e-01	0.504
HCMV Infection	R-HSA-9609646	5.035813e-01	0.298
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.847690e-01	0.415
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.166821e-01	0.287
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.363964e-01	0.360
Switching of origins to a post-replicative state	R-HSA-69052	5.188252e-01	0.285
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.050540e-01	0.516
Vasopressin-like receptors	R-HSA-388479	5.166821e-01	0.287
Ovarian tumor domain proteases	R-HSA-5689896	4.419811e-01	0.355
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	3.333552e-01	0.477
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	3.333552e-01	0.477
Signaling by FGFR2	R-HSA-5654738	3.803277e-01	0.420
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.640564e-01	0.439
TCR signaling	R-HSA-202403	5.120909e-01	0.291
Platelet sensitization by LDL	R-HSA-432142	3.050540e-01	0.516
Regulation of NPAS4 gene expression	R-HSA-9768759	2.782592e-01	0.556
Reproduction	R-HSA-1474165	4.085396e-01	0.389
Frs2-mediated activation	R-HSA-170968	3.394805e-01	0.469
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.400579e-01	0.356
Downstream signaling of activated FGFR4	R-HSA-5654716	2.735187e-01	0.563
Downstream signaling of activated FGFR2	R-HSA-5654696	3.996049e-01	0.398
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.686140e-01	0.571
Manipulation of host energy metabolism	R-HSA-9636667	3.047658e-01	0.516
mRNA Editing: A to I Conversion	R-HSA-75064	3.841122e-01	0.416
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.841122e-01	0.416
C6 deamination of adenosine	R-HSA-75102	3.841122e-01	0.416
MET interacts with TNS proteins	R-HSA-8875513	4.544069e-01	0.343
Adenosine P1 receptors	R-HSA-417973	4.544069e-01	0.343
Signaling by LTK	R-HSA-9842663	3.066800e-01	0.513
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.001490e-01	0.523
Inactivation of CDC42 and RAC1	R-HSA-428543	4.266828e-01	0.370
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.166821e-01	0.287
ATP sensitive Potassium channels	R-HSA-1296025	5.166821e-01	0.287
Netrin-1 signaling	R-HSA-373752	2.981166e-01	0.526
DNA replication initiation	R-HSA-68952	4.670470e-01	0.331
SHC-mediated cascade:FGFR2	R-HSA-5654699	3.708108e-01	0.431
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.156388e-01	0.501
Viral Messenger RNA Synthesis	R-HSA-168325	3.287330e-01	0.483
Downstream signaling of activated FGFR1	R-HSA-5654687	3.996049e-01	0.398
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.675916e-01	0.330
NGF-stimulated transcription	R-HSA-9031628	3.692041e-01	0.433
Leishmania infection	R-HSA-9658195	4.871639e-01	0.312
Parasitic Infection Pathways	R-HSA-9824443	4.871639e-01	0.312
Synthesis of DNA	R-HSA-69239	4.739126e-01	0.324
Signaling by TGFBR3	R-HSA-9839373	3.333552e-01	0.477
Developmental Biology	R-HSA-1266738	3.863803e-01	0.413
TP53 Regulates Metabolic Genes	R-HSA-5628897	2.950127e-01	0.530
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.992495e-01	0.302
G alpha (12/13) signalling events	R-HSA-416482	3.516186e-01	0.454
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.684958e-01	0.571
Transcriptional Regulation by VENTX	R-HSA-8853884	5.244608e-01	0.280
Signaling by FGFR1	R-HSA-5654736	3.731015e-01	0.428
Response of endothelial cells to shear stress	R-HSA-9860931	3.236626e-01	0.490
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.266828e-01	0.370
Signaling by NOTCH1	R-HSA-1980143	4.391802e-01	0.357
Ca-dependent events	R-HSA-111996	2.638225e-01	0.579
Transmission across Chemical Synapses	R-HSA-112315	3.152316e-01	0.501
Regulated proteolysis of p75NTR	R-HSA-193692	4.266828e-01	0.370
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.266828e-01	0.370
Synthesis of PG	R-HSA-1483148	4.675916e-01	0.330
Neuronal System	R-HSA-112316	4.264179e-01	0.370
Transcriptional Regulation by E2F6	R-HSA-8953750	3.254121e-01	0.488
Cellular responses to mechanical stimuli	R-HSA-9855142	3.613313e-01	0.442
Regulation of NF-kappa B signaling	R-HSA-9758274	4.363964e-01	0.360
G1/S Transition	R-HSA-69206	4.323072e-01	0.364
Calmodulin induced events	R-HSA-111933	2.689279e-01	0.570
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.746230e-01	0.324
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.740100e-01	0.562
TNFR1-mediated ceramide production	R-HSA-5626978	5.166821e-01	0.287
CaM pathway	R-HSA-111997	2.689279e-01	0.570
FRS-mediated FGFR1 signaling	R-HSA-5654693	3.235471e-01	0.490
Protein methylation	R-HSA-8876725	4.045370e-01	0.393
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.863820e-01	0.413
Josephin domain DUBs	R-HSA-5689877	4.670470e-01	0.331
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.570583e-01	0.447
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.131955e-01	0.504
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.944923e-01	0.404
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.675916e-01	0.330
RHOBTB3 ATPase cycle	R-HSA-9706019	5.056694e-01	0.296
DAG and IP3 signaling	R-HSA-1489509	3.156388e-01	0.501
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.761115e-01	0.425
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.876472e-01	0.312
Cardiogenesis	R-HSA-9733709	5.101942e-01	0.292
Other interleukin signaling	R-HSA-449836	3.321017e-01	0.479
Neurofascin interactions	R-HSA-447043	2.974699e-01	0.527
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.400579e-01	0.356
tRNA processing in the nucleus	R-HSA-6784531	4.744290e-01	0.324
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.731015e-01	0.428
STING mediated induction of host immune responses	R-HSA-1834941	3.321017e-01	0.479
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.841122e-01	0.416
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.670470e-01	0.331
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.363964e-01	0.360
Bicarbonate transporters	R-HSA-425381	5.056694e-01	0.296
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.419811e-01	0.355
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.837319e-01	0.315
Signaling by FGFR2 in disease	R-HSA-5655253	4.053368e-01	0.392
Signaling by Hedgehog	R-HSA-5358351	4.192033e-01	0.378
Uptake and function of diphtheria toxin	R-HSA-5336415	3.415761e-01	0.467
FasL/ CD95L signaling	R-HSA-75157	4.544069e-01	0.343
Respiratory syncytial virus genome replication	R-HSA-9834752	4.266828e-01	0.370
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.333552e-01	0.477
SARS-CoV Infections	R-HSA-9679506	5.064100e-01	0.295
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.050540e-01	0.516
RMTs methylate histone arginines	R-HSA-3214858	4.418749e-01	0.355
Unfolded Protein Response (UPR)	R-HSA-381119	5.218347e-01	0.282
Apoptosis induced DNA fragmentation	R-HSA-140342	4.670470e-01	0.331
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.363964e-01	0.360
Regulation of gene expression in beta cells	R-HSA-210745	4.180925e-01	0.379
ChREBP activates metabolic gene expression	R-HSA-163765	5.056694e-01	0.296
Replication of the SARS-CoV-1 genome	R-HSA-9682706	3.394805e-01	0.469
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.629609e-01	0.334
Replication of the SARS-CoV-2 genome	R-HSA-9694686	4.979908e-01	0.303
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.266828e-01	0.370
Extrinsic Pathway of Fibrin Clot Formation	R-HSA-140834	5.166821e-01	0.287
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	3.721703e-01	0.429
PKA activation in glucagon signalling	R-HSA-164378	5.274862e-01	0.278
PKA activation	R-HSA-163615	5.274862e-01	0.278
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.274862e-01	0.278
Synaptic adhesion-like molecules	R-HSA-8849932	5.274862e-01	0.278
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.288033e-01	0.277
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.323267e-01	0.274
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	5.364303e-01	0.270
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.399526e-01	0.268
MET activates PTK2 signaling	R-HSA-8874081	5.423221e-01	0.266
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.423221e-01	0.266
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.423221e-01	0.266
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.424218e-01	0.266
PI3K events in ERBB4 signaling	R-HSA-1250342	5.424218e-01	0.266
Signaling by GSK3beta mutants	R-HSA-5339716	5.424218e-01	0.266
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.424218e-01	0.266
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.424218e-01	0.266
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.424218e-01	0.266
Endosomal/Vacuolar pathway	R-HSA-1236977	5.424218e-01	0.266
NF-kB is activated and signals survival	R-HSA-209560	5.424218e-01	0.266
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.468221e-01	0.262
Signaling by NOTCH2	R-HSA-1980145	5.539963e-01	0.256
NPAS4 regulates expression of target genes	R-HSA-9768919	5.539963e-01	0.256
Mitophagy	R-HSA-5205647	5.539963e-01	0.256
Regulation of T cell activation by CD28 family	R-HSA-388841	5.542162e-01	0.256
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.559912e-01	0.255
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.559912e-01	0.255
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	5.559912e-01	0.255
Post-translational protein phosphorylation	R-HSA-8957275	5.598147e-01	0.252
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.618788e-01	0.250
SARS-CoV-2 Infection	R-HSA-9694516	5.632486e-01	0.249
Regulation of beta-cell development	R-HSA-186712	5.636447e-01	0.249
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.663781e-01	0.247
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.663781e-01	0.247
RNA Polymerase I Transcription Termination	R-HSA-73863	5.663781e-01	0.247
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.687225e-01	0.245
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.717832e-01	0.243
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.718524e-01	0.243
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.718524e-01	0.243
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.718524e-01	0.243
NTRK2 activates RAC1	R-HSA-9032759	5.718524e-01	0.243
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.718524e-01	0.243
FLT3 signaling by CBL mutants	R-HSA-9706377	5.718524e-01	0.243
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.718524e-01	0.243
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.718524e-01	0.243
Activation of C3 and C5	R-HSA-174577	5.718524e-01	0.243
PTK6 Activates STAT3	R-HSA-8849474	5.718524e-01	0.243
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.718524e-01	0.243
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.718524e-01	0.243
Activation of AKT2	R-HSA-165158	5.718524e-01	0.243
Muscarinic acetylcholine receptors	R-HSA-390648	5.718524e-01	0.243
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.718524e-01	0.243
Inositol transporters	R-HSA-429593	5.718524e-01	0.243
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.718524e-01	0.243
Reelin signalling pathway	R-HSA-8866376	5.718524e-01	0.243
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.718524e-01	0.243
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.718524e-01	0.243
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.718524e-01	0.243
Nectin/Necl trans heterodimerization	R-HSA-420597	5.718524e-01	0.243
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.718524e-01	0.243
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.743605e-01	0.241
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.772280e-01	0.239
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.772280e-01	0.239
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.772280e-01	0.239
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.772280e-01	0.239
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.772280e-01	0.239
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.772280e-01	0.239
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.772280e-01	0.239
Regulation of IFNG signaling	R-HSA-877312	5.772280e-01	0.239
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.829231e-01	0.234
Cellular response to chemical stress	R-HSA-9711123	5.838913e-01	0.234
Glycolysis	R-HSA-70171	5.857776e-01	0.232
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.897178e-01	0.229
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.899570e-01	0.229
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.957841e-01	0.225
RNA Polymerase III Transcription	R-HSA-74158	5.957841e-01	0.225
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.957841e-01	0.225
Lysosome Vesicle Biogenesis	R-HSA-432720	5.957841e-01	0.225
G1/S-Specific Transcription	R-HSA-69205	5.957841e-01	0.225
RNA Polymerase II Transcription Termination	R-HSA-73856	5.964344e-01	0.224
Formation of paraxial mesoderm	R-HSA-9793380	5.964344e-01	0.224
PLC beta mediated events	R-HSA-112043	5.964344e-01	0.224
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.998994e-01	0.222
G1 Phase	R-HSA-69236	6.015769e-01	0.221
Cyclin D associated events in G1	R-HSA-69231	6.015769e-01	0.221
COPII-mediated vesicle transport	R-HSA-204005	6.024674e-01	0.220
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.024674e-01	0.220
Signaling by Nuclear Receptors	R-HSA-9006931	6.029116e-01	0.220
DNA Replication Pre-Initiation	R-HSA-69002	6.041966e-01	0.219
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.056399e-01	0.218
Muscle contraction	R-HSA-397014	6.092442e-01	0.215
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.097816e-01	0.215
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.097816e-01	0.215
Basigin interactions	R-HSA-210991	6.097816e-01	0.215
Adenylate cyclase activating pathway	R-HSA-170660	6.100533e-01	0.215
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.100533e-01	0.215
Formation of axial mesoderm	R-HSA-9796292	6.100533e-01	0.215
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.100533e-01	0.215
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.100533e-01	0.215
Oxidative Stress Induced Senescence	R-HSA-2559580	6.110708e-01	0.214
Termination of translesion DNA synthesis	R-HSA-5656169	6.123019e-01	0.213
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.123019e-01	0.213
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.185825e-01	0.209
Signaling by Interleukins	R-HSA-449147	6.191784e-01	0.208
Asymmetric localization of PCP proteins	R-HSA-4608870	6.197699e-01	0.208
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.207278e-01	0.207
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.207278e-01	0.207
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.207278e-01	0.207
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.207278e-01	0.207
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.207278e-01	0.207
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.207278e-01	0.207
Signaling by MST1	R-HSA-8852405	6.207278e-01	0.207
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.207278e-01	0.207
NGF-independant TRKA activation	R-HSA-187024	6.207278e-01	0.207
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.207278e-01	0.207
PDE3B signalling	R-HSA-165160	6.207278e-01	0.207
PKB-mediated events	R-HSA-109703	6.207278e-01	0.207
Synthesis of PS	R-HSA-1483101	6.207278e-01	0.207
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.207278e-01	0.207
Signalling to p38 via RIT and RIN	R-HSA-187706	6.207278e-01	0.207
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.207278e-01	0.207
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.207278e-01	0.207
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.207278e-01	0.207
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.207278e-01	0.207
TRAIL signaling	R-HSA-75158	6.207278e-01	0.207
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.222202e-01	0.206
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.320310e-01	0.199
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	6.340996e-01	0.198
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.340996e-01	0.198
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.349844e-01	0.197
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.349844e-01	0.197
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.349844e-01	0.197
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.352888e-01	0.197
Gastrulation	R-HSA-9758941	6.389919e-01	0.195
ER-Phagosome pathway	R-HSA-1236974	6.399762e-01	0.194
Retrograde neurotrophin signalling	R-HSA-177504	6.408965e-01	0.193
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.408965e-01	0.193
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	6.408965e-01	0.193
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	6.408965e-01	0.193
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	6.408965e-01	0.193
Acyl chain remodeling of CL	R-HSA-1482798	6.408965e-01	0.193
Ion transport by P-type ATPases	R-HSA-936837	6.432028e-01	0.192
Co-inhibition by PD-1	R-HSA-389948	6.444503e-01	0.191
Interferon gamma signaling	R-HSA-877300	6.527259e-01	0.185
RAS processing	R-HSA-9648002	6.541243e-01	0.184
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.550882e-01	0.184
Cargo concentration in the ER	R-HSA-5694530	6.550882e-01	0.184
Evasion by RSV of host interferon responses	R-HSA-9833109	6.550882e-01	0.184
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.561300e-01	0.183
FGFR2 alternative splicing	R-HSA-6803529	6.590284e-01	0.181
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.590284e-01	0.181
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.590284e-01	0.181
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.590284e-01	0.181
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.590284e-01	0.181
Cytoprotection by HMOX1	R-HSA-9707564	6.628529e-01	0.179
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.640264e-01	0.178
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.640264e-01	0.178
Signaling by LTK in cancer	R-HSA-9842640	6.640264e-01	0.178
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.640264e-01	0.178
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.640264e-01	0.178
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.640264e-01	0.178
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.640264e-01	0.178
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.640264e-01	0.178
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.640264e-01	0.178
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.640264e-01	0.178
G2/M DNA replication checkpoint	R-HSA-69478	6.640264e-01	0.178
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	6.640264e-01	0.178
Abacavir transmembrane transport	R-HSA-2161517	6.640264e-01	0.178
HDL clearance	R-HSA-8964011	6.640264e-01	0.178
Leukotriene receptors	R-HSA-391906	6.640264e-01	0.178
Defective factor VIII causes hemophilia A	R-HSA-9662001	6.640264e-01	0.178
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	R-HSA-159763	6.640264e-01	0.178
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.681564e-01	0.175
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.681564e-01	0.175
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.681564e-01	0.175
Signaling by FGFR	R-HSA-190236	6.681564e-01	0.175
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.697823e-01	0.174
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.697823e-01	0.174
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.697823e-01	0.174
Beta-catenin phosphorylation cascade	R-HSA-196299	6.697823e-01	0.174
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.697823e-01	0.174
Biotin transport and metabolism	R-HSA-196780	6.697823e-01	0.174
p75NTR signals via NF-kB	R-HSA-193639	6.697823e-01	0.174
Formation of the anterior neural plate	R-HSA-9823739	6.697823e-01	0.174
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.723262e-01	0.172
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.723262e-01	0.172
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.758233e-01	0.170
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.819060e-01	0.166
Syndecan interactions	R-HSA-3000170	6.819060e-01	0.166
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.845325e-01	0.165
G-protein mediated events	R-HSA-112040	6.867316e-01	0.163
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.873973e-01	0.163
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.875661e-01	0.163
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.875661e-01	0.163
MAPK6/MAPK4 signaling	R-HSA-5687128	6.884937e-01	0.162
Signaling by Insulin receptor	R-HSA-74752	6.898961e-01	0.161
Antigen processing-Cross presentation	R-HSA-1236975	6.933027e-01	0.159
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.945819e-01	0.158
Regulation of BACH1 activity	R-HSA-9708530	6.967554e-01	0.157
Defective GALNT3 causes HFTC	R-HSA-5083625	6.967554e-01	0.157
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.967554e-01	0.157
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.967554e-01	0.157
Atorvastatin ADME	R-HSA-9754706	6.967554e-01	0.157
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.967554e-01	0.157
Differentiation of T cells	R-HSA-9945266	6.967554e-01	0.157
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.967554e-01	0.157
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.004744e-01	0.155
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.008580e-01	0.154
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.023842e-01	0.153
Defective CHSY1 causes TPBS	R-HSA-3595177	7.023842e-01	0.153
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.023842e-01	0.153
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.023842e-01	0.153
Disinhibition of SNARE formation	R-HSA-114516	7.023842e-01	0.153
Opsins	R-HSA-419771	7.023842e-01	0.153
VLDL clearance	R-HSA-8964046	7.023842e-01	0.153
Ca2+ activated K+ channels	R-HSA-1296052	7.023842e-01	0.153
Activation of TRKA receptors	R-HSA-187015	7.023842e-01	0.153
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.023842e-01	0.153
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	7.023842e-01	0.153
Phase 3 - rapid repolarisation	R-HSA-5576890	7.023842e-01	0.153
Regulation of PTEN localization	R-HSA-8948747	7.023842e-01	0.153
Netrin mediated repulsion signals	R-HSA-418886	7.023842e-01	0.153
CHL1 interactions	R-HSA-447041	7.023842e-01	0.153
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	7.023842e-01	0.153
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.023842e-01	0.153
Removal of aminoterminal propeptides from gamma-carboxylated proteins	R-HSA-159782	7.023842e-01	0.153
PI3K Cascade	R-HSA-109704	7.032077e-01	0.153
Deadenylation of mRNA	R-HSA-429947	7.036200e-01	0.153
Interleukin-6 family signaling	R-HSA-6783589	7.036200e-01	0.153
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.036200e-01	0.153
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.036200e-01	0.153
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.036200e-01	0.153
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.067873e-01	0.151
HIV Transcription Initiation	R-HSA-167161	7.067873e-01	0.151
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.067873e-01	0.151
Ub-specific processing proteases	R-HSA-5689880	7.099221e-01	0.149
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.126229e-01	0.147
RNA Polymerase I Transcription	R-HSA-73864	7.130580e-01	0.147
Meiotic recombination	R-HSA-912446	7.183112e-01	0.144
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	7.218762e-01	0.142
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	7.218762e-01	0.142
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	7.218762e-01	0.142
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.218762e-01	0.142
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	7.218762e-01	0.142
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.218762e-01	0.142
Acyl chain remodelling of PS	R-HSA-1482801	7.241822e-01	0.140
Formation of the nephric duct	R-HSA-9830364	7.241822e-01	0.140
Sensory processing of sound	R-HSA-9659379	7.253622e-01	0.139
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.307331e-01	0.136
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.307331e-01	0.136
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.307331e-01	0.136
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.307331e-01	0.136
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.307331e-01	0.136
Calnexin/calreticulin cycle	R-HSA-901042	7.307331e-01	0.136
NOD1/2 Signaling Pathway	R-HSA-168638	7.307331e-01	0.136
Orc1 removal from chromatin	R-HSA-68949	7.328738e-01	0.135
Diseases of programmed cell death	R-HSA-9645723	7.360680e-01	0.133
phospho-PLA2 pathway	R-HSA-111995	7.363647e-01	0.133
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.363647e-01	0.133
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.363647e-01	0.133
Interleukin-23 signaling	R-HSA-9020933	7.363647e-01	0.133
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.363647e-01	0.133
TGFBR3 PTM regulation	R-HSA-9839383	7.363647e-01	0.133
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.363647e-01	0.133
Sodium/Proton exchangers	R-HSA-425986	7.363647e-01	0.133
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.363647e-01	0.133
RNA Polymerase II Promoter Escape	R-HSA-73776	7.386284e-01	0.132
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.423737e-01	0.129
TRP channels	R-HSA-3295583	7.436115e-01	0.129
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.436115e-01	0.129
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.451902e-01	0.128
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	7.452159e-01	0.128
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.452159e-01	0.128
Specification of primordial germ cells	R-HSA-9827857	7.452159e-01	0.128
Uptake and function of anthrax toxins	R-HSA-5210891	7.452159e-01	0.128
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.468948e-01	0.127
Regulation of PTEN stability and activity	R-HSA-8948751	7.468948e-01	0.127
Interleukin-1 family signaling	R-HSA-446652	7.475413e-01	0.126
PERK regulates gene expression	R-HSA-381042	7.475631e-01	0.126
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.514657e-01	0.124
Platelet activation, signaling and aggregation	R-HSA-76002	7.526305e-01	0.123
G1/S DNA Damage Checkpoints	R-HSA-69615	7.551439e-01	0.122
Signaling by NOTCH	R-HSA-157118	7.595105e-01	0.119
Asparagine N-linked glycosylation	R-HSA-446203	7.597186e-01	0.119
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.619332e-01	0.118
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.619332e-01	0.118
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.634218e-01	0.117
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	7.642312e-01	0.117
rRNA processing	R-HSA-72312	7.648538e-01	0.116
C-type lectin receptors (CLRs)	R-HSA-5621481	7.650358e-01	0.116
Hemostasis	R-HSA-109582	7.652454e-01	0.116
Calcineurin activates NFAT	R-HSA-2025928	7.664672e-01	0.116
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	7.664672e-01	0.116
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.664672e-01	0.116
p75NTR regulates axonogenesis	R-HSA-193697	7.664672e-01	0.116
mRNA Editing	R-HSA-75072	7.664672e-01	0.116
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.664672e-01	0.116
MAPK1 (ERK2) activation	R-HSA-112411	7.664672e-01	0.116
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.664672e-01	0.116
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.664672e-01	0.116
Interleukin-1 processing	R-HSA-448706	7.664672e-01	0.116
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.664672e-01	0.116
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.664672e-01	0.116
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.664672e-01	0.116
Cellular response to mitochondrial stress	R-HSA-9840373	7.664672e-01	0.116
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.664672e-01	0.116
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.664672e-01	0.116
FOXO-mediated transcription of cell death genes	R-HSA-9614657	7.668536e-01	0.115
RNA Polymerase III Transcription Termination	R-HSA-73980	7.668536e-01	0.115
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.668536e-01	0.115
Apoptotic factor-mediated response	R-HSA-111471	7.668536e-01	0.115
Nephron development	R-HSA-9831926	7.668536e-01	0.115
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.678597e-01	0.115
Somitogenesis	R-HSA-9824272	7.678597e-01	0.115
Viral Infection Pathways	R-HSA-9824446	7.734736e-01	0.112
Gene Silencing by RNA	R-HSA-211000	7.745895e-01	0.111
Telomere Extension By Telomerase	R-HSA-171319	7.791778e-01	0.108
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.815123e-01	0.107
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.837705e-01	0.106
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.837705e-01	0.106
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.857344e-01	0.105
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.868737e-01	0.104
PI-3K cascade:FGFR3	R-HSA-5654710	7.868737e-01	0.104
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.868737e-01	0.104
Diseases of hemostasis	R-HSA-9671793	7.868737e-01	0.104
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.868737e-01	0.104
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.868737e-01	0.104
Maturation of nucleoprotein	R-HSA-9694631	7.868737e-01	0.104
Cap-dependent Translation Initiation	R-HSA-72737	7.909291e-01	0.102
Eukaryotic Translation Initiation	R-HSA-72613	7.909291e-01	0.102
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.926834e-01	0.101
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.931340e-01	0.101
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.931340e-01	0.101
Pexophagy	R-HSA-9664873	7.931340e-01	0.101
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.931340e-01	0.101
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.931340e-01	0.101
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.931340e-01	0.101
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.931340e-01	0.101
MAPK3 (ERK1) activation	R-HSA-110056	7.931340e-01	0.101
Maturation of spike protein	R-HSA-9683686	7.931340e-01	0.101
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.945359e-01	0.100
DARPP-32 events	R-HSA-180024	7.953793e-01	0.099
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.953793e-01	0.099
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.976240e-01	0.098
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.977660e-01	0.098
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.977660e-01	0.098
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.977660e-01	0.098
Assembly of the pre-replicative complex	R-HSA-68867	7.978337e-01	0.098
Glucose metabolism	R-HSA-70326	7.993325e-01	0.097
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.011650e-01	0.096
PI-3K cascade:FGFR4	R-HSA-5654720	8.053634e-01	0.094
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.053634e-01	0.094
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.053634e-01	0.094
Protein hydroxylation	R-HSA-9629569	8.053634e-01	0.094
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.061810e-01	0.094
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.068672e-01	0.093
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.089980e-01	0.092
Regulated Necrosis	R-HSA-5218859	8.121559e-01	0.090
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.154026e-01	0.089
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.154026e-01	0.089
PCP/CE pathway	R-HSA-4086400	8.159438e-01	0.088
Signaling by APC mutants	R-HSA-4839744	8.167572e-01	0.088
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	8.167572e-01	0.088
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	8.167572e-01	0.088
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	8.167572e-01	0.088
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.167572e-01	0.088
Ionotropic activity of kainate receptors	R-HSA-451306	8.167572e-01	0.088
vRNA Synthesis	R-HSA-192814	8.167572e-01	0.088
vRNP Assembly	R-HSA-192905	8.167572e-01	0.088
Synthesis of PI	R-HSA-1483226	8.167572e-01	0.088
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.167572e-01	0.088
LGI-ADAM interactions	R-HSA-5682910	8.167572e-01	0.088
Suppression of apoptosis	R-HSA-9635465	8.167572e-01	0.088
Dissolution of Fibrin Clot	R-HSA-75205	8.167572e-01	0.088
FCERI mediated MAPK activation	R-HSA-2871796	8.178273e-01	0.087
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.197809e-01	0.086
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.197809e-01	0.086
Extension of Telomeres	R-HSA-180786	8.198658e-01	0.086
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	8.224111e-01	0.085
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.224111e-01	0.085
Lagging Strand Synthesis	R-HSA-69186	8.224111e-01	0.085
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.224111e-01	0.085
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.224111e-01	0.085
Zygotic genome activation (ZGA)	R-HSA-9819196	8.224111e-01	0.085
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.248055e-01	0.084
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.248055e-01	0.084
Beta-catenin independent WNT signaling	R-HSA-3858494	8.262585e-01	0.083
Activation of HOX genes during differentiation	R-HSA-5619507	8.288442e-01	0.082
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.288442e-01	0.082
RAB geranylgeranylation	R-HSA-8873719	8.302382e-01	0.081
Degradation of beta-catenin by the destruction complex	R-HSA-195253	8.318684e-01	0.080
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.318684e-01	0.080
Cyclin E associated events during G1/S transition	R-HSA-69202	8.318684e-01	0.080
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.319740e-01	0.080
Hh mutants are degraded by ERAD	R-HSA-5362768	8.319740e-01	0.080
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.326694e-01	0.080
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.331565e-01	0.079
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.364111e-01	0.078
DS-GAG biosynthesis	R-HSA-2022923	8.376840e-01	0.077
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.376840e-01	0.077
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.376840e-01	0.077
Scavenging by Class H Receptors	R-HSA-3000497	8.376840e-01	0.077
Signaling by AMER1 mutants	R-HSA-4839748	8.376840e-01	0.077
Signaling by AXIN mutants	R-HSA-4839735	8.376840e-01	0.077
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.376840e-01	0.077
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.376840e-01	0.077
Activation of RAC1	R-HSA-428540	8.376840e-01	0.077
Gamma-carboxylation of protein precursors	R-HSA-159740	8.376840e-01	0.077
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.376957e-01	0.077
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.376957e-01	0.077
Attachment and Entry	R-HSA-9694614	8.381049e-01	0.077
Signaling by WNT in cancer	R-HSA-4791275	8.381111e-01	0.077
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.381111e-01	0.077
Toll-like Receptor Cascades	R-HSA-168898	8.381898e-01	0.077
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.434712e-01	0.074
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.434712e-01	0.074
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.446540e-01	0.073
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.495443e-01	0.071
Nuclear RNA decay	R-HSA-9930044	8.505343e-01	0.070
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.506957e-01	0.070
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.506957e-01	0.070
Uptake and actions of bacterial toxins	R-HSA-5339562	8.506957e-01	0.070
PI-3K cascade:FGFR1	R-HSA-5654689	8.525316e-01	0.069
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.525316e-01	0.069
LDL clearance	R-HSA-8964038	8.525316e-01	0.069
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.532186e-01	0.069
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.542984e-01	0.068
Cytosolic tRNA aminoacylation	R-HSA-379716	8.542984e-01	0.068
Interferon alpha/beta signaling	R-HSA-909733	8.545683e-01	0.068
Maple Syrup Urine Disease	R-HSA-9865114	8.562219e-01	0.067
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.562219e-01	0.067
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.562219e-01	0.067
Scavenging by Class F Receptors	R-HSA-3000484	8.562219e-01	0.067
Leading Strand Synthesis	R-HSA-69109	8.562219e-01	0.067
Polymerase switching	R-HSA-69091	8.562219e-01	0.067
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	8.562219e-01	0.067
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	8.562219e-01	0.067
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.562219e-01	0.067
VLDLR internalisation and degradation	R-HSA-8866427	8.562219e-01	0.067
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.562219e-01	0.067
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.562219e-01	0.067
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	R-HSA-159854	8.562219e-01	0.067
OAS antiviral response	R-HSA-8983711	8.562219e-01	0.067
Ca2+ pathway	R-HSA-4086398	8.583230e-01	0.066
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.585035e-01	0.066
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.602491e-01	0.065
Glucagon signaling in metabolic regulation	R-HSA-163359	8.621180e-01	0.064
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.644821e-01	0.063
TBC/RABGAPs	R-HSA-8854214	8.644821e-01	0.063
Regulation of PTEN mRNA translation	R-HSA-8943723	8.657760e-01	0.063
Termination of O-glycan biosynthesis	R-HSA-977068	8.657760e-01	0.063
Interleukin-20 family signaling	R-HSA-8854691	8.657760e-01	0.063
Carnitine shuttle	R-HSA-200425	8.657760e-01	0.063
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.692846e-01	0.061
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.692846e-01	0.061
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.726437e-01	0.059
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.726437e-01	0.059
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.726437e-01	0.059
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.726437e-01	0.059
Diseases of nucleotide metabolism	R-HSA-9735804	8.726437e-01	0.059
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.726437e-01	0.059
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.726437e-01	0.059
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.726437e-01	0.059
Maturation of nucleoprotein	R-HSA-9683610	8.726437e-01	0.059
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.729050e-01	0.059
Signal amplification	R-HSA-392518	8.729050e-01	0.059
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.729050e-01	0.059
Cellular response to hypoxia	R-HSA-1234174	8.751024e-01	0.058
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.778214e-01	0.057
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.779197e-01	0.057
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.779197e-01	0.057
DNA Replication	R-HSA-69306	8.786305e-01	0.056
Developmental Cell Lineages	R-HSA-9734767	8.814060e-01	0.055
Regulation of Apoptosis	R-HSA-169911	8.829377e-01	0.054
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.830268e-01	0.054
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.830268e-01	0.054
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.830268e-01	0.054
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.830268e-01	0.054
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.830268e-01	0.054
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.858785e-01	0.053
Ion homeostasis	R-HSA-5578775	8.858785e-01	0.053
Prolactin receptor signaling	R-HSA-1170546	8.871906e-01	0.052
CRMPs in Sema3A signaling	R-HSA-399956	8.871906e-01	0.052
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.871906e-01	0.052
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.871906e-01	0.052
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.871906e-01	0.052
Hydrolysis of LPC	R-HSA-1483115	8.871906e-01	0.052
cGMP effects	R-HSA-418457	8.871906e-01	0.052
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.871906e-01	0.052
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.871906e-01	0.052
NRIF signals cell death from the nucleus	R-HSA-205043	8.871906e-01	0.052
Zinc transporters	R-HSA-435354	8.871906e-01	0.052
Opioid Signalling	R-HSA-111885	8.882518e-01	0.051
PI-3K cascade:FGFR2	R-HSA-5654695	8.890415e-01	0.051
Laminin interactions	R-HSA-3000157	8.890415e-01	0.051
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.890415e-01	0.051
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.890415e-01	0.051
Hyaluronan degradation	R-HSA-2160916	8.890415e-01	0.051
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.890415e-01	0.051
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.890415e-01	0.051
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.898676e-01	0.051
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.922581e-01	0.050
Dectin-2 family	R-HSA-5621480	8.934754e-01	0.049
Synthesis of PA	R-HSA-1483166	8.934754e-01	0.049
Immune System	R-HSA-168256	8.949161e-01	0.048
Signaling by ROBO receptors	R-HSA-376176	8.967171e-01	0.047
Post-translational protein modification	R-HSA-597592	8.977024e-01	0.047
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.992163e-01	0.046
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.992163e-01	0.046
Sphingolipid catabolism	R-HSA-9845614	8.992163e-01	0.046
RNA Polymerase III Chain Elongation	R-HSA-73780	9.000767e-01	0.046
G beta:gamma signalling through BTK	R-HSA-8964315	9.000767e-01	0.046
Translesion synthesis by REV1	R-HSA-110312	9.000767e-01	0.046
Telomere C-strand synthesis initiation	R-HSA-174430	9.000767e-01	0.046
Protein repair	R-HSA-5676934	9.000767e-01	0.046
Beta oxidation of butanoyl-CoA to acetyl-CoA	R-HSA-77352	9.000767e-01	0.046
Other semaphorin interactions	R-HSA-416700	9.000767e-01	0.046
Processive synthesis on the lagging strand	R-HSA-69183	9.000767e-01	0.046
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.009069e-01	0.045
Voltage gated Potassium channels	R-HSA-1296072	9.009069e-01	0.045
TRAF6 mediated IRF7 activation	R-HSA-933541	9.009069e-01	0.045
Degradation of AXIN	R-HSA-4641257	9.009069e-01	0.045
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.034256e-01	0.044
Telomere Maintenance	R-HSA-157579	9.048223e-01	0.043
GPER1 signaling	R-HSA-9634597	9.066923e-01	0.043
Gluconeogenesis	R-HSA-70263	9.066923e-01	0.043
Amino acid transport across the plasma membrane	R-HSA-352230	9.073656e-01	0.042
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.073656e-01	0.042
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.085152e-01	0.042
Cristae formation	R-HSA-8949613	9.085152e-01	0.042
Signaling by BMP	R-HSA-201451	9.085152e-01	0.042
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.085152e-01	0.042
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.085152e-01	0.042
Insulin processing	R-HSA-264876	9.085152e-01	0.042
Base Excision Repair	R-HSA-73884	9.109321e-01	0.041
Translesion synthesis by POLI	R-HSA-5656121	9.114915e-01	0.040
Class I peroxisomal membrane protein import	R-HSA-9603798	9.114915e-01	0.040
WNT5A-dependent internalization of FZD4	R-HSA-5099900	9.114915e-01	0.040
Activation of the phototransduction cascade	R-HSA-2485179	9.114915e-01	0.040
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.114915e-01	0.040
Fructose catabolism	R-HSA-70350	9.114915e-01	0.040
Attachment and Entry	R-HSA-9678110	9.114915e-01	0.040
Virus Assembly and Release	R-HSA-168268	9.114915e-01	0.040
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.136973e-01	0.039
Influenza Infection	R-HSA-168255	9.138732e-01	0.039
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.145633e-01	0.039
Regulation of mitotic cell cycle	R-HSA-453276	9.153856e-01	0.038
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.153856e-01	0.038
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.163481e-01	0.038
Plasma lipoprotein clearance	R-HSA-8964043	9.163481e-01	0.038
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.170056e-01	0.038
Phase 0 - rapid depolarisation	R-HSA-5576892	9.170056e-01	0.038
Prednisone ADME	R-HSA-9757110	9.170056e-01	0.038
Pyrimidine salvage	R-HSA-73614	9.170056e-01	0.038
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.170056e-01	0.038
MAP kinase activation	R-HSA-450294	9.196452e-01	0.036
ABC-family proteins mediated transport	R-HSA-382556	9.197718e-01	0.036
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.208667e-01	0.036
Translesion synthesis by POLK	R-HSA-5655862	9.216030e-01	0.035
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	9.216030e-01	0.035
Phase 2 - plateau phase	R-HSA-5576893	9.216030e-01	0.035
Fibronectin matrix formation	R-HSA-1566977	9.216030e-01	0.035
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.216030e-01	0.035
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.216030e-01	0.035
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.216030e-01	0.035
Interleukin-1 signaling	R-HSA-9020702	9.242871e-01	0.034
DNA methylation	R-HSA-5334118	9.247507e-01	0.034
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.252278e-01	0.034
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.260089e-01	0.033
Activation of NF-kappaB in B cells	R-HSA-1169091	9.260089e-01	0.033
Hedgehog ligand biogenesis	R-HSA-5358346	9.260089e-01	0.033
TCF dependent signaling in response to WNT	R-HSA-201681	9.277760e-01	0.033
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.305597e-01	0.031
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.305597e-01	0.031
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.305597e-01	0.031
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.305597e-01	0.031
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.305597e-01	0.031
RNA Polymerase I Promoter Escape	R-HSA-73772	9.315987e-01	0.031
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.318100e-01	0.031
Collagen formation	R-HSA-1474290	9.342469e-01	0.030
Ribosome-associated quality control	R-HSA-9948299	9.344075e-01	0.029
Degradation of CRY and PER proteins	R-HSA-9932298	9.354262e-01	0.029
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.354313e-01	0.029
Amino acids regulate mTORC1	R-HSA-9639288	9.368036e-01	0.028
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.380929e-01	0.028
Molecules associated with elastic fibres	R-HSA-2129379	9.382391e-01	0.028
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.384937e-01	0.028
Vitamin D (calciferol) metabolism	R-HSA-196791	9.384937e-01	0.028
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.384937e-01	0.028
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	9.384937e-01	0.028
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.384937e-01	0.028
Mismatch Repair	R-HSA-5358508	9.384937e-01	0.028
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.384937e-01	0.028
RSV-host interactions	R-HSA-9833110	9.402262e-01	0.027
GABA B receptor activation	R-HSA-977444	9.408347e-01	0.026
Activation of GABAB receptors	R-HSA-991365	9.408347e-01	0.026
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.408347e-01	0.026
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.416061e-01	0.026
Inwardly rectifying K+ channels	R-HSA-1296065	9.440898e-01	0.025
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.440898e-01	0.025
Formation of the cornified envelope	R-HSA-6809371	9.447888e-01	0.025
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.455131e-01	0.024
Germ layer formation at gastrulation	R-HSA-9754189	9.455216e-01	0.024
E2F mediated regulation of DNA replication	R-HSA-113510	9.455216e-01	0.024
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.455216e-01	0.024
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.455216e-01	0.024
G alpha (z) signalling events	R-HSA-418597	9.461476e-01	0.024
SLC-mediated transport of amino acids	R-HSA-9958863	9.482763e-01	0.023
Kidney development	R-HSA-9830369	9.482763e-01	0.023
G-protein beta:gamma signalling	R-HSA-397795	9.494102e-01	0.023
Amine ligand-binding receptors	R-HSA-375280	9.504135e-01	0.022
Surfactant metabolism	R-HSA-5683826	9.504135e-01	0.022
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.512281e-01	0.022
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.517468e-01	0.021
Signal transduction by L1	R-HSA-445144	9.517468e-01	0.021
Acyl chain remodelling of PI	R-HSA-1482922	9.517468e-01	0.021
Formation of definitive endoderm	R-HSA-9823730	9.517468e-01	0.021
Signaling by NODAL	R-HSA-1181150	9.517468e-01	0.021
Eicosanoid ligand-binding receptors	R-HSA-391903	9.517468e-01	0.021
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.520293e-01	0.021
Signaling by WNT	R-HSA-195721	9.537643e-01	0.021
Acyl chain remodelling of PC	R-HSA-1482788	9.542452e-01	0.020
Vpu mediated degradation of CD4	R-HSA-180534	9.542452e-01	0.020
Downstream TCR signaling	R-HSA-202424	9.545105e-01	0.020
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.572609e-01	0.019
ERK/MAPK targets	R-HSA-198753	9.572609e-01	0.019
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.572609e-01	0.019
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.572609e-01	0.019
Acyl chain remodelling of PG	R-HSA-1482925	9.572609e-01	0.019
Condensation of Prophase Chromosomes	R-HSA-2299718	9.585292e-01	0.018
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.586362e-01	0.018
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.586362e-01	0.018
Hyaluronan metabolism	R-HSA-2142845	9.586362e-01	0.018
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.586362e-01	0.018
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.586362e-01	0.018
Interleukin-17 signaling	R-HSA-448424	9.588011e-01	0.018
CS-GAG biosynthesis	R-HSA-2022870	9.621453e-01	0.017
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.621453e-01	0.017
Mitochondrial calcium ion transport	R-HSA-8949215	9.621453e-01	0.017
Ribavirin ADME	R-HSA-9755088	9.621453e-01	0.017
Acyl chain remodelling of PE	R-HSA-1482839	9.626215e-01	0.017
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.626215e-01	0.017
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.626215e-01	0.017
Eukaryotic Translation Elongation	R-HSA-156842	9.629522e-01	0.016
Inositol phosphate metabolism	R-HSA-1483249	9.635282e-01	0.016
tRNA Aminoacylation	R-HSA-379724	9.642375e-01	0.016
Glutathione conjugation	R-HSA-156590	9.642375e-01	0.016
Metal ion SLC transporters	R-HSA-425410	9.653856e-01	0.015
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.662365e-01	0.015
FGFR2 mutant receptor activation	R-HSA-1839126	9.662365e-01	0.015
RAF-independent MAPK1/3 activation	R-HSA-112409	9.664717e-01	0.015
Fructose metabolism	R-HSA-5652084	9.664717e-01	0.015
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.664717e-01	0.015
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.664717e-01	0.015
Neurotoxicity of clostridium toxins	R-HSA-168799	9.664717e-01	0.015
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.664717e-01	0.015
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.664717e-01	0.015
Aquaporin-mediated transport	R-HSA-445717	9.670982e-01	0.015
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.676421e-01	0.014
Degradation of DVL	R-HSA-4641258	9.695137e-01	0.013
Collagen chain trimerization	R-HSA-8948216	9.695137e-01	0.013
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.703038e-01	0.013
ABC transporters in lipid homeostasis	R-HSA-1369062	9.703038e-01	0.013
Formation of the ureteric bud	R-HSA-9830674	9.703038e-01	0.013
Free fatty acids regulate insulin secretion	R-HSA-400451	9.703038e-01	0.013
Organic anion transport by SLCO transporters	R-HSA-879518	9.703038e-01	0.013
Biosynthesis of maresins	R-HSA-9018682	9.703038e-01	0.013
Azathioprine ADME	R-HSA-9748787	9.711625e-01	0.013
Formation of a pool of free 40S subunits	R-HSA-72689	9.719968e-01	0.012
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.719968e-01	0.012
Elastic fibre formation	R-HSA-1566948	9.724830e-01	0.012
Purine salvage	R-HSA-74217	9.724830e-01	0.012
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.735737e-01	0.012
Complex III assembly	R-HSA-9865881	9.736982e-01	0.012
TNFs bind their physiological receptors	R-HSA-5669034	9.736982e-01	0.012
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.751721e-01	0.011
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.751721e-01	0.011
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.753157e-01	0.011
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.754386e-01	0.011
PPARA activates gene expression	R-HSA-1989781	9.755528e-01	0.011
G protein gated Potassium channels	R-HSA-1296059	9.767047e-01	0.010
Activation of G protein gated Potassium channels	R-HSA-1296041	9.767047e-01	0.010
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.767047e-01	0.010
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.767047e-01	0.010
Integration of energy metabolism	R-HSA-163685	9.772593e-01	0.010
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.776062e-01	0.010
SLC transporter disorders	R-HSA-5619102	9.776131e-01	0.010
ABC transporter disorders	R-HSA-5619084	9.780069e-01	0.010
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.782417e-01	0.010
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.793677e-01	0.009
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.793677e-01	0.009
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.793677e-01	0.009
Abacavir ADME	R-HSA-2161522	9.793677e-01	0.009
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.798084e-01	0.009
Maturation of spike protein	R-HSA-9694548	9.798084e-01	0.009
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.798084e-01	0.009
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.813474e-01	0.008
Packaging Of Telomere Ends	R-HSA-171306	9.817265e-01	0.008
Maturation of hRSV A proteins	R-HSA-9828806	9.817265e-01	0.008
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.817265e-01	0.008
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.818000e-01	0.008
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.818000e-01	0.008
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.818000e-01	0.008
Translation of Structural Proteins	R-HSA-9683701	9.818000e-01	0.008
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.825558e-01	0.008
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.825558e-01	0.008
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.827282e-01	0.008
PI Metabolism	R-HSA-1483255	9.831115e-01	0.007
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.836002e-01	0.007
Cleavage of the damaged pyrimidine	R-HSA-110329	9.836002e-01	0.007
Depyrimidination	R-HSA-73928	9.836002e-01	0.007
Insulin receptor recycling	R-HSA-77387	9.838157e-01	0.007
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.838157e-01	0.007
Pyroptosis	R-HSA-5620971	9.838157e-01	0.007
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.840972e-01	0.007
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.852079e-01	0.006
FCGR activation	R-HSA-2029481	9.852079e-01	0.006
Response of Mtb to phagocytosis	R-HSA-9637690	9.852269e-01	0.006
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.853883e-01	0.006
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.856661e-01	0.006
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.860500e-01	0.006
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.866960e-01	0.006
Proteasome assembly	R-HSA-9907900	9.866960e-01	0.006
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.873051e-01	0.006
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.873051e-01	0.006
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.873508e-01	0.006
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.880225e-01	0.005
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.880225e-01	0.005
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.880225e-01	0.005
GABA receptor activation	R-HSA-977443	9.887095e-01	0.005
Budding and maturation of HIV virion	R-HSA-162588	9.887567e-01	0.005
Platelet degranulation	R-HSA-114608	9.890511e-01	0.005
Ion channel transport	R-HSA-983712	9.891282e-01	0.005
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.891990e-01	0.005
Potassium Channels	R-HSA-1296071	9.891990e-01	0.005
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.892197e-01	0.005
Cellular response to starvation	R-HSA-9711097	9.894100e-01	0.005
Nucleotide salvage	R-HSA-8956321	9.897409e-01	0.004
HS-GAG degradation	R-HSA-2024096	9.900425e-01	0.004
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.900425e-01	0.004
Mitochondrial protein import	R-HSA-1268020	9.906811e-01	0.004
Regulation of insulin secretion	R-HSA-422356	9.907903e-01	0.004
Peptide chain elongation	R-HSA-156902	9.911157e-01	0.004
Defective B3GALTL causes PpS	R-HSA-5083635	9.911813e-01	0.004
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	9.911813e-01	0.004
Translation of Structural Proteins	R-HSA-9694635	9.918185e-01	0.004
CS/DS degradation	R-HSA-2024101	9.921898e-01	0.003
Miscellaneous transport and binding events	R-HSA-5223345	9.921898e-01	0.003
Effects of PIP2 hydrolysis	R-HSA-114508	9.921898e-01	0.003
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.921898e-01	0.003
Heme degradation	R-HSA-189483	9.921898e-01	0.003
Disease	R-HSA-1643685	9.922439e-01	0.003
Leishmania parasite growth and survival	R-HSA-9664433	9.923106e-01	0.003
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.923106e-01	0.003
Innate Immune System	R-HSA-168249	9.924847e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.925013e-01	0.003
Integrin cell surface interactions	R-HSA-216083	9.925237e-01	0.003
Cell surface interactions at the vascular wall	R-HSA-202733	9.925906e-01	0.003
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.930831e-01	0.003
eNOS activation	R-HSA-203615	9.930831e-01	0.003
The phototransduction cascade	R-HSA-2514856	9.936569e-01	0.003
Branched-chain amino acid catabolism	R-HSA-70895	9.936569e-01	0.003
Transferrin endocytosis and recycling	R-HSA-917977	9.938743e-01	0.003
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.938743e-01	0.003
Neddylation	R-HSA-8951664	9.945327e-01	0.002
HS-GAG biosynthesis	R-HSA-2022928	9.945750e-01	0.002
PRC2 methylates histones and DNA	R-HSA-212300	9.945750e-01	0.002
Glycosphingolipid transport	R-HSA-9845576	9.945750e-01	0.002
Triglyceride catabolism	R-HSA-163560	9.945750e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.948779e-01	0.002
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.951956e-01	0.002
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.951956e-01	0.002
Cleavage of the damaged purine	R-HSA-110331	9.951956e-01	0.002
NCAM1 interactions	R-HSA-419037	9.951956e-01	0.002
SLC-mediated transport of organic cations	R-HSA-549127	9.951956e-01	0.002
Metabolism of folate and pterines	R-HSA-196757	9.951956e-01	0.002
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.952593e-01	0.002
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.953987e-01	0.002
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.957453e-01	0.002
Depurination	R-HSA-73927	9.957453e-01	0.002
Biofilm formation	R-HSA-9931953	9.957453e-01	0.002
Disorders of transmembrane transporters	R-HSA-5619115	9.958208e-01	0.002
Eukaryotic Translation Termination	R-HSA-72764	9.958996e-01	0.002
Hedgehog 'on' state	R-HSA-5632684	9.961301e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.962320e-01	0.002
Stimuli-sensing channels	R-HSA-2672351	9.962562e-01	0.002
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.966087e-01	0.001
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.966087e-01	0.001
Tryptophan catabolism	R-HSA-71240	9.966632e-01	0.001
Glycogen metabolism	R-HSA-8982491	9.966632e-01	0.001
Peptide ligand-binding receptors	R-HSA-375276	9.967143e-01	0.001
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.970450e-01	0.001
Aflatoxin activation and detoxification	R-HSA-5423646	9.970450e-01	0.001
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.970450e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.970728e-01	0.001
Infectious disease	R-HSA-5663205	9.972717e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.973163e-01	0.001
Sialic acid metabolism	R-HSA-4085001	9.973163e-01	0.001
Heme biosynthesis	R-HSA-189451	9.973831e-01	0.001
Scavenging by Class A Receptors	R-HSA-3000480	9.973831e-01	0.001
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.973831e-01	0.001
Iron uptake and transport	R-HSA-917937	9.973999e-01	0.001
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.973999e-01	0.001
Selenocysteine synthesis	R-HSA-2408557	9.975843e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.975921e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.976187e-01	0.001
HCMV Late Events	R-HSA-9610379	9.976487e-01	0.001
Collagen degradation	R-HSA-1442490	9.978398e-01	0.001
Defective pyroptosis	R-HSA-9710421	9.979478e-01	0.001
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.979478e-01	0.001
Viral mRNA Translation	R-HSA-192823	9.979794e-01	0.001
tRNA processing	R-HSA-72306	9.979931e-01	0.001
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.983034e-01	0.001
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.983907e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.984420e-01	0.001
Xenobiotics	R-HSA-211981	9.984420e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.985783e-01	0.001
Platelet homeostasis	R-HSA-418346	9.985906e-01	0.001
Synthesis of PC	R-HSA-1483191	9.987380e-01	0.001
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.987480e-01	0.001
Translation	R-HSA-72766	9.989710e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.989946e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.990104e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.991237e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.992116e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992287e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.992772e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.992772e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.994654e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.994810e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.995230e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.995230e-01	0.000
Protein localization	R-HSA-9609507	9.995447e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.995757e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.996253e-01	0.000
Cardiac conduction	R-HSA-5576891	9.996431e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.996670e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.996670e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.996670e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.996830e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.997068e-01	0.000
Triglyceride metabolism	R-HSA-8979227	9.997068e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.997565e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.997615e-01	0.000
Endogenous sterols	R-HSA-211976	9.997701e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.997995e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.998198e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.998294e-01	0.000
Keratinization	R-HSA-6805567	9.998816e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.998892e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999009e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.999231e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999231e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999319e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.999319e-01	0.000
Purine catabolism	R-HSA-74259	9.999397e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999466e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999466e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999467e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999557e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999605e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999685e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999705e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999725e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999743e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999744e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999749e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999759e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999784e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999799e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999914e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999915e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999924e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999936e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999939e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999940e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999949e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999981e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999982e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999986e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999987e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999992e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999995e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999996e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999997e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999997e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999998e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999999e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999999e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999999e-01	0.000
Drug ADME	R-HSA-9748784	9.999999e-01	0.000
Complement cascade	R-HSA-166658	9.999999e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell-Cell communication	R-HSA-1500931	1.110223e-16	15.955
M Phase	R-HSA-68886	1.110223e-16	15.955
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Metabolism of RNA	R-HSA-8953854	9.992007e-16	15.000
Cell junction organization	R-HSA-446728	1.241229e-13	12.906
Axon guidance	R-HSA-422475	1.818545e-13	12.740
Nervous system development	R-HSA-9675108	4.323208e-13	12.364
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.438183e-13	12.191
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.438183e-13	12.191
Cell Cycle Checkpoints	R-HSA-69620	8.020251e-13	12.096
Adherens junctions interactions	R-HSA-418990	1.445288e-12	11.840
G2/M Checkpoints	R-HSA-69481	2.395528e-12	11.621
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.579092e-11	10.802
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.371903e-11	10.472
Cell-cell junction organization	R-HSA-421270	3.894074e-11	10.410
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.536838e-11	10.021
G2/M Transition	R-HSA-69275	1.936524e-10	9.713
Apoptotic execution phase	R-HSA-75153	2.375954e-10	9.624
Mitotic G2-G2/M phases	R-HSA-453274	2.704401e-10	9.568
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.243152e-10	9.372
Mitotic Anaphase	R-HSA-68882	4.805916e-10	9.318
Apoptosis	R-HSA-109581	5.172716e-10	9.286
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.587639e-10	9.253
Mitotic Prophase	R-HSA-68875	6.446413e-10	9.191
Separation of Sister Chromatids	R-HSA-2467813	7.339790e-10	9.134
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.507618e-10	9.124
Eukaryotic Translation Elongation	R-HSA-156842	8.213669e-10	9.085
Cap-dependent Translation Initiation	R-HSA-72737	9.161218e-10	9.038
Eukaryotic Translation Initiation	R-HSA-72613	9.161218e-10	9.038
HDACs deacetylate histones	R-HSA-3214815	1.128388e-09	8.948
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.197659e-09	8.922
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.228527e-09	8.911
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.289905e-09	8.889
Mitotic Prometaphase	R-HSA-68877	1.657709e-09	8.780
Programmed Cell Death	R-HSA-5357801	1.694394e-09	8.771
Transcriptional Regulation by TP53	R-HSA-3700989	1.900600e-09	8.721
Signaling by ROBO receptors	R-HSA-376176	2.845854e-09	8.546
Assembly of the pre-replicative complex	R-HSA-68867	3.731612e-09	8.428
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.995100e-09	8.398
DNA Replication Pre-Initiation	R-HSA-69002	4.922881e-09	8.308
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.269190e-09	8.278
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.019853e-09	8.220
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.493810e-09	8.188
Viral Infection Pathways	R-HSA-9824446	6.553431e-09	8.184
Cellular response to heat stress	R-HSA-3371556	7.960006e-09	8.099
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.342503e-09	8.030
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.809191e-09	8.008
Aggrephagy	R-HSA-9646399	1.147935e-08	7.940
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.147935e-08	7.940
rRNA processing	R-HSA-72312	1.173046e-08	7.931
G2/M DNA damage checkpoint	R-HSA-69473	1.494262e-08	7.826
Protein ubiquitination	R-HSA-8852135	1.918551e-08	7.717
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.166854e-08	7.664
Membrane Trafficking	R-HSA-199991	2.110849e-08	7.676
Interleukin-12 signaling	R-HSA-9020591	2.453350e-08	7.610
SARS-CoV-1-host interactions	R-HSA-9692914	2.765705e-08	7.558
HSF1-dependent transactivation	R-HSA-3371571	2.780501e-08	7.556
Recycling pathway of L1	R-HSA-437239	3.555995e-08	7.449
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.741925e-08	7.427
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.744290e-08	7.427
Regulation of CDH1 Function	R-HSA-9764561	3.799858e-08	7.420
RNA Polymerase I Transcription	R-HSA-73864	3.964752e-08	7.402
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.964752e-08	7.402
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.499086e-08	7.347
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.010117e-08	7.300
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.581031e-08	7.182
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.714550e-08	7.060
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.714550e-08	7.060
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.830537e-08	7.054
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.380131e-08	7.028
Ribosome-associated quality control	R-HSA-9948299	9.201925e-08	7.036
NoRC negatively regulates rRNA expression	R-HSA-427413	9.711726e-08	7.013
Interleukin-12 family signaling	R-HSA-447115	1.080754e-07	6.966
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.180973e-07	6.928
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.312105e-07	6.882
Peptide chain elongation	R-HSA-156902	1.334748e-07	6.875
Diseases of programmed cell death	R-HSA-9645723	1.334748e-07	6.875
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.498128e-07	6.824
Influenza Infection	R-HSA-168255	1.693518e-07	6.771
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.770400e-07	6.752
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.047451e-07	6.689
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.169659e-07	6.664
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.555151e-07	6.593
Formation of a pool of free 40S subunits	R-HSA-72689	2.555151e-07	6.593
Attenuation phase	R-HSA-3371568	2.527996e-07	6.597
Processing of DNA double-strand break ends	R-HSA-5693607	2.692353e-07	6.570
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.699837e-07	6.569
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.873403e-07	6.542
HSF1 activation	R-HSA-3371511	3.157523e-07	6.501
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.315145e-07	6.365
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.324738e-07	6.364
Cellular Senescence	R-HSA-2559583	4.768408e-07	6.322
DNA Double Strand Break Response	R-HSA-5693606	4.840091e-07	6.315
mRNA Splicing - Major Pathway	R-HSA-72163	4.998006e-07	6.301
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.085585e-07	6.216
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.500610e-07	6.187
L1CAM interactions	R-HSA-373760	7.186786e-07	6.143
mRNA Splicing	R-HSA-72172	8.248958e-07	6.084
Post NMDA receptor activation events	R-HSA-438064	1.113754e-06	5.953
Kinesins	R-HSA-983189	1.194862e-06	5.923
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.324664e-06	5.878
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.343080e-06	5.872
SARS-CoV-1 Infection	R-HSA-9678108	1.447797e-06	5.839
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.595665e-06	5.797
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.600817e-06	5.796
Signaling downstream of RAS mutants	R-HSA-9649948	1.907206e-06	5.720
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.907206e-06	5.720
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.907206e-06	5.720
Signaling by RAS mutants	R-HSA-6802949	1.907206e-06	5.720
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.955510e-06	5.709
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.072955e-06	5.683
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.230708e-06	5.652
Chromatin organization	R-HSA-4839726	2.311971e-06	5.636
Striated Muscle Contraction	R-HSA-390522	2.479897e-06	5.606
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.347836e-06	5.629
DNA Replication	R-HSA-69306	2.494306e-06	5.603
Signal Transduction	R-HSA-162582	2.571595e-06	5.590
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.663362e-06	5.575
Regulation of endogenous retroelements	R-HSA-9842860	2.676256e-06	5.572
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.676256e-06	5.572
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.758364e-06	5.559
Meiotic synapsis	R-HSA-1221632	2.945669e-06	5.531
Transport of connexons to the plasma membrane	R-HSA-190872	3.242742e-06	5.489
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.373460e-06	5.472
HCMV Early Events	R-HSA-9609690	3.395349e-06	5.469
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.544566e-06	5.450
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.655735e-06	5.437
Selective autophagy	R-HSA-9663891	4.061710e-06	5.391
Golgi-to-ER retrograde transport	R-HSA-8856688	4.154391e-06	5.381
Chromatin modifying enzymes	R-HSA-3247509	4.717148e-06	5.326
Transcriptional regulation by small RNAs	R-HSA-5578749	4.740756e-06	5.324
RNA Polymerase I Promoter Opening	R-HSA-73728	5.376518e-06	5.269
Hedgehog 'off' state	R-HSA-5610787	5.396681e-06	5.268
PRC2 methylates histones and DNA	R-HSA-212300	6.070091e-06	5.217
Nucleosome assembly	R-HSA-774815	5.651377e-06	5.248
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.651377e-06	5.248
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.070091e-06	5.217
Eukaryotic Translation Termination	R-HSA-72764	6.636303e-06	5.178
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.025848e-06	5.153
Homology Directed Repair	R-HSA-5693538	7.088229e-06	5.149
Condensation of Prophase Chromosomes	R-HSA-2299718	7.247247e-06	5.140
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.445726e-06	5.128
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.586743e-06	5.120
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.643784e-06	5.117
Signaling by RAF1 mutants	R-HSA-9656223	7.754506e-06	5.110
RNA Polymerase I Promoter Escape	R-HSA-73772	8.327598e-06	5.079
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.016053e-05	4.993
HIV Infection	R-HSA-162906	1.028820e-05	4.988
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.165507e-05	4.933
Translation initiation complex formation	R-HSA-72649	1.302450e-05	4.885
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.250225e-05	4.903
DNA Double-Strand Break Repair	R-HSA-5693532	1.415662e-05	4.849
Selenocysteine synthesis	R-HSA-2408557	1.721095e-05	4.764
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.777403e-05	4.750
Chaperone Mediated Autophagy	R-HSA-9613829	1.820223e-05	4.740
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.858094e-05	4.731
Signaling by ALK in cancer	R-HSA-9700206	1.858094e-05	4.731
Estrogen-dependent gene expression	R-HSA-9018519	1.984228e-05	4.702
Ribosomal scanning and start codon recognition	R-HSA-72702	1.997383e-05	4.700
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.091151e-05	4.680
HIV Life Cycle	R-HSA-162587	2.274961e-05	4.643
Viral mRNA Translation	R-HSA-192823	2.323579e-05	4.634
Packaging Of Telomere Ends	R-HSA-171306	2.460214e-05	4.609
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.567560e-05	4.590
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.007118e-05	4.522
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.992820e-05	4.524
Gene expression (Transcription)	R-HSA-74160	3.042314e-05	4.517
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	3.084652e-05	4.511
Ub-specific processing proteases	R-HSA-5689880	3.096449e-05	4.509
Regulation of MECP2 expression and activity	R-HSA-9022692	3.316496e-05	4.479
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.327667e-05	4.478
Deubiquitination	R-HSA-5688426	3.494645e-05	4.457
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.841566e-05	4.415
Nephrin family interactions	R-HSA-373753	3.841566e-05	4.415
TCF dependent signaling in response to WNT	R-HSA-201681	4.142014e-05	4.383
Neurodegenerative Diseases	R-HSA-8863678	4.314439e-05	4.365
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.314439e-05	4.365
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.314439e-05	4.365
DNA methylation	R-HSA-5334118	4.450853e-05	4.352
Folding of actin by CCT/TriC	R-HSA-390450	4.459406e-05	4.351
AURKA Activation by TPX2	R-HSA-8854518	4.469115e-05	4.350
Degradation of CDH1	R-HSA-9766229	5.041920e-05	4.297
Oncogenic MAPK signaling	R-HSA-6802957	4.792007e-05	4.319
Meiosis	R-HSA-1500620	4.792007e-05	4.319
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.798617e-05	4.319
Gap junction trafficking and regulation	R-HSA-157858	5.041920e-05	4.297
Gene Silencing by RNA	R-HSA-211000	4.749511e-05	4.323
Defective pyroptosis	R-HSA-9710421	4.635793e-05	4.334
Oxidative Stress Induced Senescence	R-HSA-2559580	5.195801e-05	4.284
Co-inhibition by PD-1	R-HSA-389948	5.201863e-05	4.284
Switching of origins to a post-replicative state	R-HSA-69052	5.232437e-05	4.281
ESR-mediated signaling	R-HSA-8939211	5.387312e-05	4.269
COPI-mediated anterograde transport	R-HSA-6807878	5.652187e-05	4.248
Nuclear events mediated by NFE2L2	R-HSA-9759194	6.559460e-05	4.183
Protein folding	R-HSA-391251	7.083625e-05	4.150
Vesicle-mediated transport	R-HSA-5653656	7.311998e-05	4.136
ISG15 antiviral mechanism	R-HSA-1169408	7.324017e-05	4.135
Meiotic recombination	R-HSA-912446	7.611797e-05	4.119
Chaperonin-mediated protein folding	R-HSA-390466	7.632103e-05	4.117
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.769449e-05	4.110
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.769449e-05	4.110
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.769449e-05	4.110
Nuclear Envelope Breakdown	R-HSA-2980766	7.785595e-05	4.109
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.235777e-05	4.084
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.913858e-05	4.050
HATs acetylate histones	R-HSA-3214847	8.652436e-05	4.063
HCMV Infection	R-HSA-9609646	8.547623e-05	4.068
S Phase	R-HSA-69242	9.171884e-05	4.038
Cytokine Signaling in Immune system	R-HSA-1280215	9.739889e-05	4.011
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.001883e-04	3.999
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.029053e-04	3.988
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.029053e-04	3.988
Late Phase of HIV Life Cycle	R-HSA-162599	1.043673e-04	3.981
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.047799e-04	3.980
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.104668e-04	3.957
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.104668e-04	3.957
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.166070e-04	3.933
Signaling by VEGF	R-HSA-194138	1.207655e-04	3.918
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.288866e-04	3.890
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.288866e-04	3.890
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.362079e-04	3.866
Regulation of T cell activation by CD28 family	R-HSA-388841	1.401268e-04	3.853
Transcriptional regulation by RUNX1	R-HSA-8878171	1.532862e-04	3.814
Infectious disease	R-HSA-5663205	1.626512e-04	3.789
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.638877e-04	3.785
GP1b-IX-V activation signalling	R-HSA-430116	1.830360e-04	3.737
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.726003e-04	3.763
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.910260e-04	3.719
Epigenetic regulation of gene expression	R-HSA-212165	1.796496e-04	3.746
Translation	R-HSA-72766	1.800228e-04	3.745
Gap junction trafficking	R-HSA-190828	1.935955e-04	3.713
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.725243e-04	3.763
Macroautophagy	R-HSA-1632852	1.840112e-04	3.735
Cilium Assembly	R-HSA-5617833	1.699909e-04	3.770
SARS-CoV-2-host interactions	R-HSA-9705683	1.815054e-04	3.741
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.910260e-04	3.719
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.080198e-04	3.682
Autophagy	R-HSA-9612973	2.125394e-04	3.673
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.485448e-04	3.605
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.485448e-04	3.605
Cellular response to starvation	R-HSA-9711097	2.593598e-04	3.586
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.794088e-04	3.554
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.794088e-04	3.554
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.858888e-04	3.544
Orc1 removal from chromatin	R-HSA-68949	2.858888e-04	3.544
Signaling by Hedgehog	R-HSA-5358351	2.891979e-04	3.539
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.940513e-04	3.532
Apoptosis induced DNA fragmentation	R-HSA-140342	2.954969e-04	3.529
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.007609e-04	3.522
Regulation of TP53 Activity	R-HSA-5633007	3.151679e-04	3.501
Metalloprotease DUBs	R-HSA-5689901	3.205584e-04	3.494
CaM pathway	R-HSA-111997	3.255735e-04	3.487
Calmodulin induced events	R-HSA-111933	3.255735e-04	3.487
Muscle contraction	R-HSA-397014	3.330656e-04	3.477
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.415504e-04	3.467
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.415504e-04	3.467
Smooth Muscle Contraction	R-HSA-445355	3.415504e-04	3.467
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.415641e-04	3.467
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.422020e-04	3.466
Transcriptional Regulation by MECP2	R-HSA-8986944	3.436424e-04	3.464
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.445973e-04	3.463
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.465896e-04	3.460
Signaling by ERBB2	R-HSA-1227986	3.888048e-04	3.410
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.963537e-04	3.402
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.029987e-04	3.395
Cleavage of the damaged purine	R-HSA-110331	4.029987e-04	3.395
Ca-dependent events	R-HSA-111996	4.166919e-04	3.380
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.166919e-04	3.380
PKR-mediated signaling	R-HSA-9833482	4.191456e-04	3.378
EPH-Ephrin signaling	R-HSA-2682334	4.457252e-04	3.351
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.577016e-04	3.339
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	4.813762e-04	3.318
Centrosome maturation	R-HSA-380287	5.291857e-04	3.276
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.516427e-04	3.258
Host Interactions of HIV factors	R-HSA-162909	4.816206e-04	3.317
Selenoamino acid metabolism	R-HSA-2408522	4.597434e-04	3.337
Signaling by NOTCH	R-HSA-157118	4.728546e-04	3.325
Depurination	R-HSA-73927	4.955264e-04	3.305
Cell-extracellular matrix interactions	R-HSA-446353	5.659284e-04	3.247
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.659284e-04	3.247
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.680334e-04	3.246
FLT3 signaling by CBL mutants	R-HSA-9706377	6.228643e-04	3.206
Semaphorin interactions	R-HSA-373755	6.244226e-04	3.205
Synthesis of DNA	R-HSA-69239	6.397422e-04	3.194
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.406206e-04	3.193
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.406206e-04	3.193
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.406206e-04	3.193
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.406206e-04	3.193
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.840968e-04	3.165
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.173711e-04	3.144
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.173711e-04	3.144
Gap junction assembly	R-HSA-190861	7.173711e-04	3.144
DAG and IP3 signaling	R-HSA-1489509	7.283325e-04	3.138
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.352318e-04	3.134
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.352318e-04	3.134
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.406837e-04	3.130
Chromosome Maintenance	R-HSA-73886	7.577054e-04	3.120
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.699814e-04	3.114
Regulation of mitotic cell cycle	R-HSA-453276	7.699814e-04	3.114
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.699814e-04	3.114
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.924539e-04	3.101
Formation of RNA Pol II elongation complex	R-HSA-112382	8.310278e-04	3.080
Downregulation of ERBB2 signaling	R-HSA-8863795	8.353788e-04	3.078
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.685042e-04	3.061
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.800043e-04	3.056
Regulation of Apoptosis	R-HSA-169911	8.800043e-04	3.056
TCR signaling	R-HSA-202403	8.932440e-04	3.049
Signaling by WNT	R-HSA-195721	9.087529e-04	3.042
MHC class II antigen presentation	R-HSA-2132295	9.311003e-04	3.031
Signaling by Interleukins	R-HSA-449147	9.422348e-04	3.026
Sema4D in semaphorin signaling	R-HSA-400685	9.488757e-04	3.023
Platelet activation, signaling and aggregation	R-HSA-76002	9.499210e-04	3.022
RNA Polymerase II Transcription	R-HSA-73857	9.528113e-04	3.021
SARS-CoV Infections	R-HSA-9679506	9.739632e-04	3.011
RNA Polymerase II Transcription Elongation	R-HSA-75955	9.771341e-04	3.010
VLDLR internalisation and degradation	R-HSA-8866427	9.912152e-04	3.004
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.015136e-03	2.993
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.038154e-03	2.984
Intracellular signaling by second messengers	R-HSA-9006925	1.050051e-03	2.979
MAP2K and MAPK activation	R-HSA-5674135	1.065749e-03	2.972
Clathrin-mediated endocytosis	R-HSA-8856828	1.081345e-03	2.966
Cellular response to chemical stress	R-HSA-9711123	1.100029e-03	2.959
Signaling by EGFR in Cancer	R-HSA-1643713	1.198908e-03	2.921
Mitotic Spindle Checkpoint	R-HSA-69618	1.301730e-03	2.885
PTEN Regulation	R-HSA-6807070	1.371059e-03	2.863
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.342164e-03	2.872
Degradation of DVL	R-HSA-4641258	1.298153e-03	2.887
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.298153e-03	2.887
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.397582e-03	2.855
MAPK family signaling cascades	R-HSA-5683057	1.406384e-03	2.852
Amyloid fiber formation	R-HSA-977225	1.182193e-03	2.927
Glycolysis	R-HSA-70171	1.301730e-03	2.885
Cleavage of the damaged pyrimidine	R-HSA-110329	1.272720e-03	2.895
Depyrimidination	R-HSA-73928	1.272720e-03	2.895
Signaling by Hippo	R-HSA-2028269	1.429721e-03	2.845
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.446743e-03	2.840
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.500228e-03	2.824
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.500228e-03	2.824
ER to Golgi Anterograde Transport	R-HSA-199977	1.547213e-03	2.810
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.567480e-03	2.805
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.634582e-03	2.787
Signaling by PTK6	R-HSA-8848021	1.634582e-03	2.787
Interferon Signaling	R-HSA-913531	1.653447e-03	2.782
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.721864e-03	2.764
Josephin domain DUBs	R-HSA-5689877	1.721864e-03	2.764
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.787653e-03	2.748
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.868570e-03	2.728
Stabilization of p53	R-HSA-69541	1.868570e-03	2.728
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.880054e-03	2.726
Vpu mediated degradation of CD4	R-HSA-180534	1.901252e-03	2.721
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.923569e-03	2.716
MAPK6/MAPK4 signaling	R-HSA-5687128	1.925565e-03	2.715
PCP/CE pathway	R-HSA-4086400	1.934570e-03	2.713
Telomere Maintenance	R-HSA-157579	2.066659e-03	2.685
Organelle biogenesis and maintenance	R-HSA-1852241	2.086559e-03	2.681
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.103422e-03	2.677
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.103422e-03	2.677
Developmental Biology	R-HSA-1266738	2.118326e-03	2.674
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.181008e-03	2.661
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.181008e-03	2.661
Late endosomal microautophagy	R-HSA-9615710	2.287055e-03	2.641
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.293736e-03	2.639
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.435377e-03	2.613
RAF/MAP kinase cascade	R-HSA-5673001	2.451337e-03	2.611
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.481667e-03	2.605
SARS-CoV-2 Infection	R-HSA-9694516	2.527957e-03	2.597
Hh mutants are degraded by ERAD	R-HSA-5362768	2.630002e-03	2.580
Regulation of PTEN stability and activity	R-HSA-8948751	2.630974e-03	2.580
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.630974e-03	2.580
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.703801e-03	2.568
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.749410e-03	2.561
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.749410e-03	2.561
Cellular responses to mechanical stimuli	R-HSA-9855142	2.848420e-03	2.545
Regulation of PTEN localization	R-HSA-8948747	2.938640e-03	2.532
Cohesin Loading onto Chromatin	R-HSA-2470946	2.938640e-03	2.532
Platelet degranulation	R-HSA-114608	3.058106e-03	2.515
Degradation of CRY and PER proteins	R-HSA-9932298	3.095885e-03	2.509
PLC beta mediated events	R-HSA-112043	3.125019e-03	2.505
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.275383e-03	2.485
ATP-dependent chromatin remodelers	R-HSA-9932444	3.344608e-03	2.476
SWI/SNF chromatin remodelers	R-HSA-9932451	3.344608e-03	2.476
NF-kB is activated and signals survival	R-HSA-209560	3.469213e-03	2.460
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.469213e-03	2.460
UCH proteinases	R-HSA-5689603	3.541556e-03	2.451
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.623163e-03	2.441
MAPK1/MAPK3 signaling	R-HSA-5684996	3.677353e-03	2.434
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.858361e-03	2.414
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.858361e-03	2.414
MITF-M-regulated melanocyte development	R-HSA-9730414	3.871053e-03	2.412
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.877988e-03	2.411
Degradation of AXIN	R-HSA-4641257	3.879148e-03	2.411
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.879148e-03	2.411
Basigin interactions	R-HSA-210991	3.925318e-03	2.406
Signaling by EGFR	R-HSA-177929	3.991014e-03	2.399
Cyclin E associated events during G1/S transition	R-HSA-69202	4.032944e-03	2.394
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.032944e-03	2.394
G1/S DNA Damage Checkpoints	R-HSA-69615	4.043525e-03	2.393
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.099131e-03	2.387
Response of endothelial cells to shear stress	R-HSA-9860931	4.202035e-03	2.377
Hh mutants abrogate ligand secretion	R-HSA-5387390	4.227780e-03	2.374
Nectin/Necl trans heterodimerization	R-HSA-420597	4.805607e-03	2.318
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.805607e-03	2.318
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.382276e-03	2.358
Pervasive developmental disorders	R-HSA-9005895	4.722635e-03	2.326
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.722635e-03	2.326
Disorders of Nervous System Development	R-HSA-9697154	4.722635e-03	2.326
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.894215e-03	2.310
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.894215e-03	2.310
EPHA-mediated growth cone collapse	R-HSA-3928663	4.980418e-03	2.303
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.351783e-03	2.272
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.806353e-03	2.318
Amplification of signal from the kinetochores	R-HSA-141424	4.806353e-03	2.318
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.722635e-03	2.326
Regulation of RAS by GAPs	R-HSA-5658442	4.444674e-03	2.352
Downregulation of ERBB4 signaling	R-HSA-1253288	4.382276e-03	2.358
Activation of NF-kappaB in B cells	R-HSA-1169091	5.100686e-03	2.292
ROBO receptors bind AKAP5	R-HSA-9010642	4.382276e-03	2.358
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.382276e-03	2.358
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	4.840326e-03	2.315
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.669591e-03	2.246
Circadian clock	R-HSA-9909396	5.089002e-03	2.293
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.739034e-03	2.241
Transcriptional regulation by RUNX3	R-HSA-8878159	4.415385e-03	2.355
Generic Transcription Pathway	R-HSA-212436	4.547202e-03	2.342
Reproduction	R-HSA-1474165	4.314283e-03	2.365
Asymmetric localization of PCP proteins	R-HSA-4608870	5.669591e-03	2.246
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.832112e-03	2.234
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.237311e-03	2.205
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.280772e-03	2.202
Signaling by NOTCH4	R-HSA-9013694	6.373853e-03	2.196
G-protein mediated events	R-HSA-112040	6.541045e-03	2.184
Regulation of PTEN gene transcription	R-HSA-8943724	6.639883e-03	2.178
Dual Incision in GG-NER	R-HSA-5696400	6.762851e-03	2.170
RAF activation	R-HSA-5673000	6.762851e-03	2.170
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.762851e-03	2.170
DNA Repair	R-HSA-73894	6.864234e-03	2.163
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.889163e-03	2.162
MITF-M-dependent gene expression	R-HSA-9856651	6.960605e-03	2.157
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.161921e-03	2.145
ER-Phagosome pathway	R-HSA-1236974	7.211456e-03	2.142
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.233877e-03	2.141
Transcription of the HIV genome	R-HSA-167172	7.327544e-03	2.135
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.327544e-03	2.135
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.545001e-03	2.122
Maturation of protein E	R-HSA-9683683	7.613917e-03	2.118
Maturation of protein E	R-HSA-9694493	7.613917e-03	2.118
NRIF signals cell death from the nucleus	R-HSA-205043	8.182476e-03	2.087
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.667714e-03	2.062
Glucose metabolism	R-HSA-70326	8.722277e-03	2.059
Regulation of signaling by CBL	R-HSA-912631	8.907343e-03	2.050
Degradation of beta-catenin by the destruction complex	R-HSA-195253	9.126563e-03	2.040
RET signaling	R-HSA-8853659	9.230153e-03	2.035
FLT3 signaling in disease	R-HSA-9682385	9.230153e-03	2.035
Mitotic G1 phase and G1/S transition	R-HSA-453279	9.359846e-03	2.029
G1/S Transition	R-HSA-69206	9.488755e-03	2.023
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.632567e-03	2.016
Trafficking of AMPA receptors	R-HSA-399719	1.004905e-02	1.998
Evasion by RSV of host interferon responses	R-HSA-9833109	1.004905e-02	1.998
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.014851e-02	1.994
Hedgehog 'on' state	R-HSA-5632684	1.014851e-02	1.994
p75NTR signals via NF-kB	R-HSA-193639	1.046593e-02	1.980
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.046593e-02	1.980
Spry regulation of FGF signaling	R-HSA-1295596	1.046593e-02	1.980
Long-term potentiation	R-HSA-9620244	1.068931e-02	1.971
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.069629e-02	1.971
Ovarian tumor domain proteases	R-HSA-5689896	1.069629e-02	1.971
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.069629e-02	1.971
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.083284e-02	1.965
Negative regulation of MET activity	R-HSA-6807004	1.094584e-02	1.961
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.163302e-02	1.934
PECAM1 interactions	R-HSA-210990	1.163302e-02	1.934
Diseases of mitotic cell cycle	R-HSA-9675126	1.177339e-02	1.929
Dual incision in TC-NER	R-HSA-6782135	1.214616e-02	1.916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.242248e-02	1.906
Hedgehog ligand biogenesis	R-HSA-5358346	1.242248e-02	1.906
RMTs methylate histone arginines	R-HSA-3214858	1.251208e-02	1.903
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.255120e-02	1.901
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.316800e-02	1.880
Negative regulation of FLT3	R-HSA-9706369	1.316800e-02	1.880
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.330295e-02	1.876
Beta-catenin independent WNT signaling	R-HSA-3858494	1.362490e-02	1.866
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.370946e-02	1.863
Integrin signaling	R-HSA-354192	1.370946e-02	1.863
Regulation of necroptotic cell death	R-HSA-5675482	1.370946e-02	1.863
Activation of ATR in response to replication stress	R-HSA-176187	1.370946e-02	1.863
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.370946e-02	1.863
mRNA 3'-end processing	R-HSA-72187	1.398134e-02	1.854
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.415083e-02	1.849
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.420107e-02	1.848
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.420107e-02	1.848
RNA Polymerase I Transcription Termination	R-HSA-73863	1.500192e-02	1.824
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.522186e-02	1.818
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.522186e-02	1.818
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.587156e-02	1.799
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.587156e-02	1.799
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.591492e-02	1.798
Diseases of Telomere Maintenance	R-HSA-9673013	1.591492e-02	1.798
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.591492e-02	1.798
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.591492e-02	1.798
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.591492e-02	1.798
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.591492e-02	1.798
Downstream TCR signaling	R-HSA-202424	1.600045e-02	1.796
Base Excision Repair	R-HSA-73884	1.600045e-02	1.796
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.600343e-02	1.796
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.600343e-02	1.796
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.600343e-02	1.796
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.600343e-02	1.796
MECP2 regulates transcription factors	R-HSA-9022707	1.604663e-02	1.795
RUNX3 regulates WNT signaling	R-HSA-8951430	1.604663e-02	1.795
Uptake and function of diphtheria toxin	R-HSA-5336415	1.604663e-02	1.795
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.616214e-02	1.792
Interactions of Rev with host cellular proteins	R-HSA-177243	1.616214e-02	1.792
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.616214e-02	1.792
Disorders of Developmental Biology	R-HSA-9675151	1.632369e-02	1.787
Signaling by Nuclear Receptors	R-HSA-9006931	1.733390e-02	1.761
HIV elongation arrest and recovery	R-HSA-167287	1.757695e-02	1.755
Pausing and recovery of HIV elongation	R-HSA-167290	1.757695e-02	1.755
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.763234e-02	1.754
Activation of HOX genes during differentiation	R-HSA-5619507	1.763234e-02	1.754
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.808786e-02	1.743
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.827372e-02	1.738
Nuclear import of Rev protein	R-HSA-180746	1.827372e-02	1.738
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.907098e-02	1.720
p75NTR recruits signalling complexes	R-HSA-209543	1.948346e-02	1.710
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.948346e-02	1.710
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.948346e-02	1.710
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.948346e-02	1.710
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.023833e-02	1.694
Regulation of gap junction activity	R-HSA-191650	2.023833e-02	1.694
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.023833e-02	1.694
Type I hemidesmosome assembly	R-HSA-446107	2.183745e-02	1.661
Formation of annular gap junctions	R-HSA-196025	2.183745e-02	1.661
Gap junction degradation	R-HSA-190873	2.875580e-02	1.541
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.446037e-02	1.612
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.996553e-02	1.700
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.996553e-02	1.700
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.996553e-02	1.700
Ephrin signaling	R-HSA-3928664	2.412320e-02	1.618
PKA activation	R-HSA-163615	2.412320e-02	1.618
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.365180e-02	1.626
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.365180e-02	1.626
EGFR downregulation	R-HSA-182971	2.718410e-02	1.566
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.718410e-02	1.566
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.718410e-02	1.566
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.092959e-02	1.679
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.346660e-02	1.630
snRNP Assembly	R-HSA-191859	2.937285e-02	1.532
Metabolism of non-coding RNA	R-HSA-194441	2.937285e-02	1.532
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.040197e-02	1.690
Neutrophil degranulation	R-HSA-6798695	2.798018e-02	1.553
Translesion Synthesis by POLH	R-HSA-110320	2.882311e-02	1.540
Regulation of TP53 Degradation	R-HSA-6804757	2.385236e-02	1.622
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.183745e-02	1.661
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.875580e-02	1.541
Budding and maturation of HIV virion	R-HSA-162588	2.718410e-02	1.566
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.023833e-02	1.694
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.875580e-02	1.541
Adaptive Immune System	R-HSA-1280218	2.702700e-02	1.568
Rap1 signalling	R-HSA-392517	2.882311e-02	1.540
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.183745e-02	1.661
Unwinding of DNA	R-HSA-176974	2.875580e-02	1.541
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.546949e-02	1.594
Hemostasis	R-HSA-109582	2.566473e-02	1.591
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.636070e-02	1.579
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.346660e-02	1.630
Unfolded Protein Response (UPR)	R-HSA-381119	2.861931e-02	1.543
Modulation by Mtb of host immune system	R-HSA-9637628	2.183745e-02	1.661
Activation of BH3-only proteins	R-HSA-114452	2.365180e-02	1.626
EPHB-mediated forward signaling	R-HSA-3928662	2.950139e-02	1.530
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.950139e-02	1.530
Opioid Signalling	R-HSA-111885	2.998733e-02	1.523
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.998733e-02	1.523
PIP3 activates AKT signaling	R-HSA-1257604	2.999421e-02	1.523
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.018783e-02	1.520
Regulation of KIT signaling	R-HSA-1433559	3.018783e-02	1.520
Signal regulatory protein family interactions	R-HSA-391160	3.018783e-02	1.520
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	3.018783e-02	1.520
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.037282e-02	1.518
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.054824e-02	1.515
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.054824e-02	1.515
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.056322e-02	1.515
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.119504e-02	1.506
HCMV Late Events	R-HSA-9610379	3.206219e-02	1.494
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.268628e-02	1.486
Regulated Necrosis	R-HSA-5218859	3.294943e-02	1.482
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.325637e-02	1.478
Manipulation of host energy metabolism	R-HSA-9636667	3.365599e-02	1.473
Breakdown of the nuclear lamina	R-HSA-352238	3.365599e-02	1.473
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.408807e-02	1.467
Signal transduction by L1	R-HSA-445144	3.408807e-02	1.467
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.434440e-02	1.464
Transcriptional Regulation by E2F6	R-HSA-8953750	3.434440e-02	1.464
Plasma lipoprotein clearance	R-HSA-8964043	3.434440e-02	1.464
Signaling by ALK	R-HSA-201556	3.434440e-02	1.464
IPs transport between nucleus and cytosol	R-HSA-1855170	3.531167e-02	1.452
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.531167e-02	1.452
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.531167e-02	1.452
RNA Polymerase II Transcription Termination	R-HSA-73856	3.543234e-02	1.451
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.669347e-02	1.435
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.669347e-02	1.435
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.669347e-02	1.435
Translesion synthesis by REV1	R-HSA-110312	3.669347e-02	1.435
Protein methylation	R-HSA-8876725	3.669347e-02	1.435
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.669347e-02	1.435
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.683556e-02	1.434
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.683556e-02	1.434
Pexophagy	R-HSA-9664873	3.683556e-02	1.434
p75 NTR receptor-mediated signalling	R-HSA-193704	3.769851e-02	1.424
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.797086e-02	1.421
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.845335e-02	1.415
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.845335e-02	1.415
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.911304e-02	1.408
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.993249e-02	1.399
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.993249e-02	1.399
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.107497e-02	1.386
Signaling by NOTCH3	R-HSA-9012852	4.171735e-02	1.380
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.181783e-02	1.379
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.181783e-02	1.379
Aryl hydrocarbon receptor signalling	R-HSA-8937144	4.181783e-02	1.379
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.181783e-02	1.379
Antigen processing-Cross presentation	R-HSA-1236975	4.219488e-02	1.375
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.288440e-02	1.368
FLT3 Signaling	R-HSA-9607240	4.288440e-02	1.368
Interleukin-1 signaling	R-HSA-9020702	4.324716e-02	1.364
Translesion synthesis by POLI	R-HSA-5656121	4.399710e-02	1.357
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.399710e-02	1.357
Regulation of NF-kappa B signaling	R-HSA-9758274	4.399710e-02	1.357
Transmission across Chemical Synapses	R-HSA-112315	4.416149e-02	1.355
Intraflagellar transport	R-HSA-5620924	4.471001e-02	1.350
Mitophagy	R-HSA-5205647	4.493934e-02	1.347
Ion homeostasis	R-HSA-5578775	4.571155e-02	1.340
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.571155e-02	1.340
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.764588e-02	1.322
HIV Transcription Initiation	R-HSA-167161	4.764588e-02	1.322
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.764588e-02	1.322
DNA Damage Bypass	R-HSA-73893	4.921305e-02	1.308
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.982187e-02	1.303
Cellular response to hypoxia	R-HSA-1234174	5.010876e-02	1.300
Translesion synthesis by POLK	R-HSA-5655862	5.211074e-02	1.283
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.211074e-02	1.283
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.211074e-02	1.283
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.211074e-02	1.283
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.211074e-02	1.283
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.211074e-02	1.283
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.211074e-02	1.283
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.247160e-02	1.280
Termination of translesion DNA synthesis	R-HSA-5656169	5.247160e-02	1.280
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.247160e-02	1.280
DARPP-32 events	R-HSA-180024	5.247160e-02	1.280
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.344293e-02	1.272
mTORC1-mediated signalling	R-HSA-166208	5.344293e-02	1.272
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.344293e-02	1.272
Transport to the Golgi and subsequent modification	R-HSA-948021	5.505591e-02	1.259
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.562227e-02	1.255
Signaling by LTK in cancer	R-HSA-9842640	5.562227e-02	1.255
Potential therapeutics for SARS	R-HSA-9679191	5.611466e-02	1.251
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	5.626512e-02	1.250
Integration of provirus	R-HSA-162592	5.652297e-02	1.248
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.652297e-02	1.248
RNA Polymerase II Promoter Escape	R-HSA-73776	5.818797e-02	1.235
Activation of the pre-replicative complex	R-HSA-68962	5.912131e-02	1.228
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.912131e-02	1.228
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.946152e-02	1.226
Nucleotide Excision Repair	R-HSA-5696398	5.962675e-02	1.225
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.103877e-02	1.214
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	6.111744e-02	1.214
Syndecan interactions	R-HSA-3000170	6.111744e-02	1.214
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.351584e-02	1.197
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.626652e-02	1.179
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.811087e-02	1.167
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.811087e-02	1.167
IRAK1 recruits IKK complex	R-HSA-937039	6.811087e-02	1.167
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.811087e-02	1.167
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.941119e-02	1.159
Deadenylation of mRNA	R-HSA-429947	6.941119e-02	1.159
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.958021e-02	1.158
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.012379e-02	1.154
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.012379e-02	1.154
PKA activation in glucagon signalling	R-HSA-164378	7.077822e-02	1.150
GAB1 signalosome	R-HSA-180292	7.077822e-02	1.150
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.077822e-02	1.150
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.077822e-02	1.150
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.390962e-02	1.131
tRNA processing in the nucleus	R-HSA-6784531	7.516104e-02	1.124
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.602630e-02	1.119
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.602630e-02	1.119
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.662296e-02	1.116
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.662296e-02	1.116
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.832274e-02	1.106
Platelet Adhesion to exposed collagen	R-HSA-75892	8.082397e-02	1.092
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.082397e-02	1.092
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.131913e-02	1.090
The NLRP3 inflammasome	R-HSA-844456	8.131913e-02	1.090
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.131913e-02	1.090
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	8.205045e-02	1.086
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.220083e-02	1.085
Axonal growth stimulation	R-HSA-209563	8.271518e-02	1.082
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.347842e-02	1.078
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.347842e-02	1.078
HIV Transcription Elongation	R-HSA-167169	8.348323e-02	1.078
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.348323e-02	1.078
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.730727e-01	0.762
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.730727e-01	0.762
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.730727e-01	0.762
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.730727e-01	0.762
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.730727e-01	0.762
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.730727e-01	0.762
Defective F8 binding to von Willebrand factor	R-HSA-9672393	1.730727e-01	0.762
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	1.730727e-01	0.762
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.121251e-01	0.950
NADE modulates death signalling	R-HSA-205025	1.121251e-01	0.950
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.121251e-01	0.950
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.437416e-01	0.842
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	1.437416e-01	0.842
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	1.437416e-01	0.842
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	8.872763e-02	1.052
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.077356e-01	0.968
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.077356e-01	0.968
Calcineurin activates NFAT	R-HSA-2025928	1.077356e-01	0.968
ALK mutants bind TKIs	R-HSA-9700645	1.077356e-01	0.968
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.281600e-01	0.892
2-LTR circle formation	R-HSA-164843	1.281600e-01	0.892
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	1.281600e-01	0.892
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.498266e-01	0.824
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.094402e-01	0.961
Phosphorylation of the APC/C	R-HSA-176412	1.252265e-01	0.902
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.725592e-01	0.763
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.047335e-01	0.980
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.175566e-01	0.930
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.797406e-02	1.009
Interaction between L1 and Ankyrins	R-HSA-445095	9.797406e-02	1.009
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.797406e-02	1.009
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.797406e-02	1.009
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.086920e-01	0.964
Formation of the Early Elongation Complex	R-HSA-113418	1.086920e-01	0.964
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.452718e-01	0.838
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.452718e-01	0.838
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.452718e-01	0.838
DAP12 signaling	R-HSA-2424491	1.318324e-01	0.880
TRAF6 mediated NF-kB activation	R-HSA-933542	1.600864e-01	0.796
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.195017e-01	0.923
GPER1 signaling	R-HSA-9634597	1.686023e-01	0.773
Post-translational protein phosphorylation	R-HSA-8957275	1.621650e-01	0.790
RNA Polymerase III Transcription	R-HSA-74158	1.195017e-01	0.923
Early Phase of HIV Life Cycle	R-HSA-162594	1.047335e-01	0.980
Generation of second messenger molecules	R-HSA-202433	1.642868e-01	0.784
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.135500e-02	1.039
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.135500e-02	1.039
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.642868e-01	0.784
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.642868e-01	0.784
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.318324e-01	0.880
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.784674e-02	1.056
Lysosome Vesicle Biogenesis	R-HSA-432720	1.195017e-01	0.923
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.094402e-01	0.961
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	1.437416e-01	0.842
Regulation of CDH11 function	R-HSA-9762292	1.281600e-01	0.892
PI3K/AKT activation	R-HSA-198203	1.281600e-01	0.892
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.461847e-02	1.024
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.310817e-01	0.882
DNA strand elongation	R-HSA-69190	1.571040e-01	0.804
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.419078e-01	0.848
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.505926e-01	0.822
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.367845e-01	0.864
Cyclin D associated events in G1	R-HSA-69231	1.269117e-01	0.896
G1 Phase	R-HSA-69236	1.269117e-01	0.896
Proteasome assembly	R-HSA-9907900	1.269117e-01	0.896
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.576422e-01	0.802
Developmental Cell Lineages	R-HSA-9734767	1.383553e-01	0.859
Pyrophosphate hydrolysis	R-HSA-71737	1.437416e-01	0.842
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.281600e-01	0.892
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.725592e-01	0.763
Fanconi Anemia Pathway	R-HSA-6783310	1.367845e-01	0.864
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.072037e-01	0.970
PKMTs methylate histone lysines	R-HSA-3214841	9.135500e-02	1.039
Regulation of pyruvate metabolism	R-HSA-9861718	1.470319e-01	0.833
Signaling by SCF-KIT	R-HSA-1433557	1.174240e-01	0.930
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.461847e-02	1.024
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.252265e-01	0.902
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.077356e-01	0.968
Extra-nuclear estrogen signaling	R-HSA-9009391	1.204014e-01	0.919
Inhibition of PKR	R-HSA-169131	1.730727e-01	0.762
MTF1 activates gene expression	R-HSA-5660489	1.121251e-01	0.950
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.437416e-01	0.842
Cellular response to mitochondrial stress	R-HSA-9840373	1.077356e-01	0.968
Regulation of FZD by ubiquitination	R-HSA-4641263	1.594093e-01	0.797
Notch-HLH transcription pathway	R-HSA-350054	1.310817e-01	0.882
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.918607e-02	1.050
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.367845e-01	0.864
Viral Messenger RNA Synthesis	R-HSA-168325	1.270058e-01	0.896
C-type lectin receptors (CLRs)	R-HSA-5621481	1.465394e-01	0.834
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.537803e-01	0.813
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.419078e-01	0.848
GPVI-mediated activation cascade	R-HSA-114604	1.195017e-01	0.923
Signaling by FGFR2	R-HSA-5654738	1.391487e-01	0.857
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.086920e-01	0.964
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.199845e-01	0.921
Negative regulation of MAPK pathway	R-HSA-5675221	9.963891e-02	1.002
Uptake and actions of bacterial toxins	R-HSA-5339562	1.230586e-01	0.910
Protein hydroxylation	R-HSA-9629569	9.264503e-02	1.033
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.047335e-01	0.980
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.704764e-01	0.768
Signaling by FGFR4	R-HSA-5654743	1.174240e-01	0.930
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.086920e-01	0.964
Signaling by FGFR3	R-HSA-5654741	1.367845e-01	0.864
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.600864e-01	0.796
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.310817e-01	0.882
Immune System	R-HSA-168256	1.383610e-01	0.859
LDL clearance	R-HSA-8964038	1.310817e-01	0.882
Disease	R-HSA-1643685	8.765128e-02	1.057
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.437416e-01	0.842
Signaling by PDGFR in disease	R-HSA-9671555	1.175566e-01	0.930
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.571040e-01	0.804
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.063934e-02	1.043
Somitogenesis	R-HSA-9824272	1.367845e-01	0.864
Signaling by TGFB family members	R-HSA-9006936	1.324322e-01	0.878
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.047335e-01	0.980
Gluconeogenesis	R-HSA-70263	1.686023e-01	0.773
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.094402e-01	0.961
Assembly Of The HIV Virion	R-HSA-175474	1.175566e-01	0.930
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.135500e-02	1.039
Transcriptional Regulation by VENTX	R-HSA-8853884	9.135500e-02	1.039
Sensory processing of sound	R-HSA-9659379	1.315010e-01	0.881
Interleukin-1 family signaling	R-HSA-446652	1.393221e-01	0.856
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.175566e-01	0.930
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.544674e-01	0.811
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.033222e-01	0.986
Transcriptional regulation by RUNX2	R-HSA-8878166	1.385951e-01	0.858
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.188324e-01	0.925
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.264503e-02	1.033
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.419078e-01	0.848
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.188324e-01	0.925
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.188324e-01	0.925
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.188324e-01	0.925
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.188324e-01	0.925
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.442137e-01	0.841
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.918607e-02	1.050
ABC transporter disorders	R-HSA-5619084	1.240916e-01	0.906
IRE1alpha activates chaperones	R-HSA-381070	1.072305e-01	0.970
XBP1(S) activates chaperone genes	R-HSA-381038	1.255002e-01	0.901
Glycogen synthesis	R-HSA-3322077	9.264503e-02	1.033
Regulation of BACH1 activity	R-HSA-9708530	1.252265e-01	0.902
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.918607e-02	1.050
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.825718e-02	1.008
Glycogen storage diseases	R-HSA-3229121	1.594093e-01	0.797
Assembly of Viral Components at the Budding Site	R-HSA-168316	1.437416e-01	0.842
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.746119e-01	0.758
HDMs demethylate histones	R-HSA-3214842	1.754819e-01	0.756
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	1.769239e-01	0.752
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.769239e-01	0.752
Noncanonical activation of NOTCH3	R-HSA-9017802	1.769239e-01	0.752
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.769239e-01	0.752
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.769239e-01	0.752
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.769239e-01	0.752
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.769239e-01	0.752
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.776522e-01	0.750
ABC-family proteins mediated transport	R-HSA-382556	1.778318e-01	0.750
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	1.794785e-01	0.746
Glucagon signaling in metabolic regulation	R-HSA-163359	1.843021e-01	0.734
Translation of Structural Proteins	R-HSA-9683701	1.891182e-01	0.723
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.914123e-01	0.718
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.914123e-01	0.718
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.915791e-01	0.718
MyD88-independent TLR4 cascade	R-HSA-166166	1.915791e-01	0.718
Deadenylation-dependent mRNA decay	R-HSA-429914	1.923539e-01	0.716
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.961838e-01	0.707
Repression of WNT target genes	R-HSA-4641265	1.961838e-01	0.707
Signaling by LTK	R-HSA-9842663	1.961838e-01	0.707
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.965555e-01	0.707
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.985507e-01	0.702
Calnexin/calreticulin cycle	R-HSA-901042	1.985507e-01	0.702
Signaling by NOTCH2	R-HSA-1980145	1.985507e-01	0.702
MTOR signalling	R-HSA-165159	2.020735e-01	0.694
Metabolism of proteins	R-HSA-392499	2.026037e-01	0.693
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.055867e-01	0.687
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.078299e-01	0.682
Pyruvate metabolism	R-HSA-70268	2.083542e-01	0.681
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.111286e-01	0.675
Autointegration results in viral DNA circles	R-HSA-177539	2.111286e-01	0.675
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	2.111286e-01	0.675
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	2.111286e-01	0.675
Nef and signal transduction	R-HSA-164944	2.111286e-01	0.675
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.111286e-01	0.675
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.131903e-01	0.671
Oncogene Induced Senescence	R-HSA-2559585	2.131903e-01	0.671
Response of Mtb to phagocytosis	R-HSA-9637690	2.153584e-01	0.667
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.160368e-01	0.665
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.160368e-01	0.665
Co-inhibition by CTLA4	R-HSA-389513	2.160368e-01	0.665
Formation of definitive endoderm	R-HSA-9823730	2.160368e-01	0.665
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.161976e-01	0.665
Signaling by MET	R-HSA-6806834	2.210225e-01	0.656
Phase 0 - rapid depolarisation	R-HSA-5576892	2.246854e-01	0.648
Inflammasomes	R-HSA-622312	2.246854e-01	0.648
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.360134e-01	0.627
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.360134e-01	0.627
Signaling by Erythropoietin	R-HSA-9006335	2.419289e-01	0.616
mRNA Capping	R-HSA-72086	2.419289e-01	0.616
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.419289e-01	0.616
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.428080e-01	0.615
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.428080e-01	0.615
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.428080e-01	0.615
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	2.428218e-01	0.615
HDL assembly	R-HSA-8963896	2.454395e-01	0.610
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.458984e-01	0.609
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.458984e-01	0.609
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.458984e-01	0.609
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.458984e-01	0.609
Disinhibition of SNARE formation	R-HSA-114516	2.458984e-01	0.609
Recycling of eIF2:GDP	R-HSA-72731	2.458984e-01	0.609
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.458984e-01	0.609
Nef Mediated CD4 Down-regulation	R-HSA-167590	2.458984e-01	0.609
CHL1 interactions	R-HSA-447041	2.458984e-01	0.609
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.458984e-01	0.609
Mitochondrial transcription initiation	R-HSA-163282	2.480358e-01	0.605
NFG and proNGF binds to p75NTR	R-HSA-205017	2.480358e-01	0.605
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.480358e-01	0.605
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	2.480358e-01	0.605
PTEN Loss of Function in Cancer	R-HSA-5674404	2.480358e-01	0.605
Defective VWF binding to collagen type I	R-HSA-9845622	2.480358e-01	0.605
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.480358e-01	0.605
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.480358e-01	0.605
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	2.480358e-01	0.605
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.480358e-01	0.605
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.480358e-01	0.605
Transport of connexins along the secretory pathway	R-HSA-190827	2.480358e-01	0.605
Oligomerization of connexins into connexons	R-HSA-190704	2.480358e-01	0.605
NTRK3 as a dependence receptor	R-HSA-9603505	2.480358e-01	0.605
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.500908e-01	0.602
Ion transport by P-type ATPases	R-HSA-936837	2.500908e-01	0.602
FOXO-mediated transcription	R-HSA-9614085	2.524980e-01	0.598
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	2.525457e-01	0.598
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.564035e-01	0.591
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.564035e-01	0.591
Signaling by ERBB4	R-HSA-1236394	2.574447e-01	0.589
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.595099e-01	0.586
Signaling by FGFR1	R-HSA-5654736	2.669693e-01	0.574
Iron uptake and transport	R-HSA-917937	2.689963e-01	0.570
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.707553e-01	0.567
DCC mediated attractive signaling	R-HSA-418885	2.707553e-01	0.567
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.707553e-01	0.567
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.707553e-01	0.567
RAS processing	R-HSA-9648002	2.749889e-01	0.561
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	2.749889e-01	0.561
Regulation of IFNA/IFNB signaling	R-HSA-912694	2.771267e-01	0.557
FGFR2 alternative splicing	R-HSA-6803529	2.771267e-01	0.557
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.771267e-01	0.557
Signaling by NOTCH1	R-HSA-1980143	2.807056e-01	0.552
EGFR interacts with phospholipase C-gamma	R-HSA-212718	2.808499e-01	0.552
Signaling by MRAS-complex mutants	R-HSA-9660537	2.808499e-01	0.552
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.808499e-01	0.552
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.808499e-01	0.552
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	2.808499e-01	0.552
Co-stimulation by ICOS	R-HSA-9927354	2.808499e-01	0.552
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.808499e-01	0.552
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.808499e-01	0.552
Death Receptor Signaling	R-HSA-73887	2.858695e-01	0.544
Co-stimulation by CD28	R-HSA-389356	2.858760e-01	0.544
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.858760e-01	0.544
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.898578e-01	0.538
Glycogen metabolism	R-HSA-8982491	2.910762e-01	0.536
G0 and Early G1	R-HSA-1538133	2.954837e-01	0.529
Activation of SMO	R-HSA-5635838	2.963350e-01	0.528
Prolonged ERK activation events	R-HSA-169893	2.963350e-01	0.528
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.963350e-01	0.528
Class I peroxisomal membrane protein import	R-HSA-9603798	2.963350e-01	0.528
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.963350e-01	0.528
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.963350e-01	0.528
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.981050e-01	0.526
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.006206e-01	0.522
Peroxisomal protein import	R-HSA-9033241	3.075505e-01	0.512
FGFR1 mutant receptor activation	R-HSA-1839124	3.137776e-01	0.503
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.137776e-01	0.503
ARMS-mediated activation	R-HSA-170984	3.156647e-01	0.501
Regulated proteolysis of p75NTR	R-HSA-193692	3.156647e-01	0.501
WNT mediated activation of DVL	R-HSA-201688	3.156647e-01	0.501
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.156647e-01	0.501
p75NTR regulates axonogenesis	R-HSA-193697	3.156647e-01	0.501
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.156647e-01	0.501
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.156647e-01	0.501
Respiratory syncytial virus genome replication	R-HSA-9834752	3.156647e-01	0.501
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.156647e-01	0.501
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.162074e-01	0.500
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.162074e-01	0.500
Defective AHCY causes HMAHCHD	R-HSA-5578997	3.162074e-01	0.500
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.162074e-01	0.500
Defective F8 cleavage by thrombin	R-HSA-9672391	3.162074e-01	0.500
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.162074e-01	0.500
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.162074e-01	0.500
Transcription from mitochondrial promoters	R-HSA-75944	3.162074e-01	0.500
Signalling to ERK5	R-HSA-198765	3.162074e-01	0.500
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.162074e-01	0.500
Signaling by NTRKs	R-HSA-166520	3.189616e-01	0.496
Acetylcholine regulates insulin secretion	R-HSA-399997	3.220453e-01	0.492
Signaling by FGFR1 in disease	R-HSA-5655302	3.237732e-01	0.490
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	3.251311e-01	0.488
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.322119e-01	0.479
Aquaporin-mediated transport	R-HSA-445717	3.352963e-01	0.475
MAP kinase activation	R-HSA-450294	3.352963e-01	0.475
Formation of paraxial mesoderm	R-HSA-9793380	3.352963e-01	0.475
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.403147e-01	0.468
TGFBR3 expression	R-HSA-9839394	3.405287e-01	0.468
Signaling by FGFR	R-HSA-190236	3.441452e-01	0.463
PI3K events in ERBB2 signaling	R-HSA-1963642	3.477638e-01	0.459
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.477638e-01	0.459
Binding and entry of HIV virion	R-HSA-173107	3.500807e-01	0.456
EGFR Transactivation by Gastrin	R-HSA-2179392	3.500807e-01	0.456
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.500807e-01	0.456
Receptor Mediated Mitophagy	R-HSA-8934903	3.500807e-01	0.456
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.500807e-01	0.456
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.507398e-01	0.455
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.556883e-01	0.449
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.556883e-01	0.449
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.556883e-01	0.449
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.556917e-01	0.449
Myogenesis	R-HSA-525793	3.618336e-01	0.441
Suppression of phagosomal maturation	R-HSA-9637687	3.618336e-01	0.441
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.664543e-01	0.436
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	3.667286e-01	0.436
PERK regulates gene expression	R-HSA-381042	3.693164e-01	0.433
Neuronal System	R-HSA-112316	3.726676e-01	0.429
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.733794e-01	0.428
RNA Polymerase III Transcription Termination	R-HSA-73980	3.733794e-01	0.428
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.733794e-01	0.428
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.733794e-01	0.428
DAP12 interactions	R-HSA-2172127	3.736174e-01	0.428
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.765079e-01	0.424
PLC-gamma1 signalling	R-HSA-167021	3.782023e-01	0.422
Activated NTRK3 signals through PLCG1	R-HSA-9034793	3.782023e-01	0.422
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.782023e-01	0.422
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.782023e-01	0.422
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.782023e-01	0.422
MET interacts with TNS proteins	R-HSA-8875513	3.782023e-01	0.422
Intracellular oxygen transport	R-HSA-8981607	3.782023e-01	0.422
Histamine receptors	R-HSA-390650	3.782023e-01	0.422
Cristae formation	R-HSA-8949613	3.831132e-01	0.417
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.831132e-01	0.417
ER Quality Control Compartment (ERQC)	R-HSA-901032	3.831132e-01	0.417
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.831132e-01	0.417
Bicarbonate transporters	R-HSA-425381	3.838842e-01	0.416
vRNP Assembly	R-HSA-192905	3.838842e-01	0.416
Interleukin-2 signaling	R-HSA-9020558	3.838842e-01	0.416
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.869253e-01	0.412
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.869253e-01	0.412
Triglyceride catabolism	R-HSA-163560	3.878986e-01	0.411
Protein-protein interactions at synapses	R-HSA-6794362	3.909636e-01	0.408
G alpha (z) signalling events	R-HSA-418597	3.914183e-01	0.407
Disorders of transmembrane transporters	R-HSA-5619115	3.985664e-01	0.399
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.987914e-01	0.399
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.987914e-01	0.399
Maturation of nucleoprotein	R-HSA-9694631	3.987914e-01	0.399
STING mediated induction of host immune responses	R-HSA-1834941	3.987914e-01	0.399
Inositol phosphate metabolism	R-HSA-1483249	3.989827e-01	0.399
Mitochondrial protein degradation	R-HSA-9837999	4.020757e-01	0.396
Pyroptosis	R-HSA-5620971	4.043071e-01	0.393
NRAGE signals death through JNK	R-HSA-193648	4.067076e-01	0.391
mRNA Splicing - Minor Pathway	R-HSA-72165	4.070021e-01	0.390
Regulation of TNFR1 signaling	R-HSA-5357905	4.070021e-01	0.390
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.098770e-01	0.387
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.113316e-01	0.386
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.160626e-01	0.381
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.169035e-01	0.380
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.169035e-01	0.380
Sodium/Calcium exchangers	R-HSA-425561	4.169035e-01	0.380
Translation of Structural Proteins	R-HSA-9694635	4.181066e-01	0.379
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.183234e-01	0.378
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.183234e-01	0.378
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.239102e-01	0.373
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.239102e-01	0.373
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.239102e-01	0.373
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.239102e-01	0.373
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	4.249166e-01	0.372
Platelet calcium homeostasis	R-HSA-418360	4.253592e-01	0.371
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.253592e-01	0.371
Activated NTRK2 signals through PLCG1	R-HSA-9026527	4.345799e-01	0.362
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.345799e-01	0.362
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.345799e-01	0.362
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.345799e-01	0.362
Signaling by MAP2K mutants	R-HSA-9652169	4.345799e-01	0.362
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.345799e-01	0.362
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.345799e-01	0.362
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.345799e-01	0.362
Sensory perception of sour taste	R-HSA-9729555	4.345799e-01	0.362
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.345799e-01	0.362
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	4.345799e-01	0.362
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.425957e-01	0.354
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.432764e-01	0.353
Pentose phosphate pathway	R-HSA-71336	4.432764e-01	0.353
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.432764e-01	0.353
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.451820e-01	0.351
GABA synthesis, release, reuptake and degradation	R-HSA-888590	4.462175e-01	0.350
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.462175e-01	0.350
Interleukin-37 signaling	R-HSA-9008059	4.462175e-01	0.350
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.483779e-01	0.348
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.486563e-01	0.348
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.490030e-01	0.348
Leading Strand Synthesis	R-HSA-69109	4.490030e-01	0.348
Polymerase switching	R-HSA-69091	4.490030e-01	0.348
Scavenging by Class F Receptors	R-HSA-3000484	4.490030e-01	0.348
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.490030e-01	0.348
Regulation of IFNG signaling	R-HSA-877312	4.490030e-01	0.348
Protein localization	R-HSA-9609507	4.586870e-01	0.338
Interleukin-2 family signaling	R-HSA-451927	4.614897e-01	0.336
Regulation of insulin secretion	R-HSA-422356	4.616141e-01	0.336
Interleukin-17 signaling	R-HSA-448424	4.624408e-01	0.335
Downstream signal transduction	R-HSA-186763	4.668346e-01	0.331
Metabolism of polyamines	R-HSA-351202	4.674650e-01	0.330
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.800782e-01	0.319
CD28 dependent Vav1 pathway	R-HSA-389359	4.800782e-01	0.319
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.800782e-01	0.319
Formation of axial mesoderm	R-HSA-9796292	4.800782e-01	0.319
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.800782e-01	0.319
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.800782e-01	0.319
Frs2-mediated activation	R-HSA-170968	4.800782e-01	0.319
Maturation of nucleoprotein	R-HSA-9683610	4.800782e-01	0.319
Replication of the SARS-CoV-1 genome	R-HSA-9682706	4.800782e-01	0.319
IRS activation	R-HSA-74713	4.858489e-01	0.313
G2 Phase	R-HSA-68911	4.858489e-01	0.313
Defective F9 activation	R-HSA-9673221	4.858489e-01	0.313
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.858489e-01	0.313
PTK6 Down-Regulation	R-HSA-8849472	4.858489e-01	0.313
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.858489e-01	0.313
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.858489e-01	0.313
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.858489e-01	0.313
Muscarinic acetylcholine receptors	R-HSA-390648	4.858489e-01	0.313
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.858489e-01	0.313
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.858489e-01	0.313
Co-inhibition by BTLA	R-HSA-9927353	4.858489e-01	0.313
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.858489e-01	0.313
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	4.967614e-01	0.304
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.967614e-01	0.304
Neurotoxicity of clostridium toxins	R-HSA-168799	4.967614e-01	0.304
Signaling by KIT in disease	R-HSA-9669938	4.967614e-01	0.304
NCAM signaling for neurite out-growth	R-HSA-375165	4.973164e-01	0.303
Signaling by PDGF	R-HSA-186797	4.973164e-01	0.303
Post-translational protein modification	R-HSA-597592	4.996805e-01	0.301
Neurexins and neuroligins	R-HSA-6794361	5.053690e-01	0.296
G-protein beta:gamma signalling	R-HSA-397795	5.071768e-01	0.295
Nuclear RNA decay	R-HSA-9930044	5.071768e-01	0.295
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.071768e-01	0.295
Retrograde neurotrophin signalling	R-HSA-177504	5.100509e-01	0.292
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.100509e-01	0.292
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.100509e-01	0.292
Signaling by FGFR4 in disease	R-HSA-5655291	5.100509e-01	0.292
Zinc transporters	R-HSA-435354	5.100509e-01	0.292
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.100509e-01	0.292
Cytosolic tRNA aminoacylation	R-HSA-379716	5.149391e-01	0.288
Signaling by FGFR in disease	R-HSA-1226099	5.178074e-01	0.286
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.200089e-01	0.284
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.200089e-01	0.284
Interleukin receptor SHC signaling	R-HSA-912526	5.200089e-01	0.284
Growth hormone receptor signaling	R-HSA-982772	5.200089e-01	0.284
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.268281e-01	0.278
Plus-strand DNA synthesis	R-HSA-164525	5.324718e-01	0.274
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.324718e-01	0.274
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.324718e-01	0.274
Phosphorylation of Emi1	R-HSA-176417	5.324718e-01	0.274
IkBA variant leads to EDA-ID	R-HSA-5603029	5.324718e-01	0.274
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.324718e-01	0.274
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.324718e-01	0.274
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.324718e-01	0.274
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.324718e-01	0.274
Pentose phosphate pathway disease	R-HSA-6791465	5.324718e-01	0.274
Ceramide signalling	R-HSA-193681	5.324718e-01	0.274
Cam-PDE 1 activation	R-HSA-111957	5.324718e-01	0.274
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.324718e-01	0.274
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.324718e-01	0.274
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.324718e-01	0.274
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.324718e-01	0.274
RNA Polymerase III Chain Elongation	R-HSA-73780	5.388656e-01	0.269
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.388656e-01	0.269
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.388656e-01	0.269
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.388656e-01	0.269
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	5.426595e-01	0.265
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.426595e-01	0.265
Plasma lipoprotein assembly	R-HSA-8963898	5.426595e-01	0.265
RSV-host interactions	R-HSA-9833110	5.431214e-01	0.265
eNOS activation	R-HSA-203615	5.460904e-01	0.263
NOD1/2 Signaling Pathway	R-HSA-168638	5.460904e-01	0.263
NPAS4 regulates expression of target genes	R-HSA-9768919	5.460904e-01	0.263
Netrin-1 signaling	R-HSA-373752	5.493096e-01	0.260
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.633629e-01	0.249
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.646776e-01	0.248
Acyl chain remodelling of PS	R-HSA-1482801	5.646776e-01	0.248
MicroRNA (miRNA) biogenesis	R-HSA-203927	5.646776e-01	0.248
Interleukin-7 signaling	R-HSA-1266695	5.646776e-01	0.248
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.649369e-01	0.248
Signalling to ERKs	R-HSA-187687	5.649369e-01	0.248
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.664858e-01	0.247
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.664858e-01	0.247
Killing mechanisms	R-HSA-9664420	5.664858e-01	0.247
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.664858e-01	0.247
Virus Assembly and Release	R-HSA-168268	5.664858e-01	0.247
TNF signaling	R-HSA-75893	5.675594e-01	0.246
G alpha (12/13) signalling events	R-HSA-416482	5.710910e-01	0.243
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.748696e-01	0.240
Erythropoietin activates STAT5	R-HSA-9027283	5.748696e-01	0.240
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.748696e-01	0.240
Uncoating of the HIV Virion	R-HSA-162585	5.748696e-01	0.240
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	5.748696e-01	0.240
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	5.748696e-01	0.240
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.748696e-01	0.240
CREB phosphorylation	R-HSA-199920	5.748696e-01	0.240
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.748696e-01	0.240
Defective factor VIII causes hemophilia A	R-HSA-9662001	5.748696e-01	0.240
NADPH regeneration	R-HSA-389542	5.748696e-01	0.240
Neurofascin interactions	R-HSA-447043	5.748696e-01	0.240
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.748696e-01	0.240
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	5.824609e-01	0.235
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	5.824609e-01	0.235
Signaling by TGFBR3	R-HSA-9839373	5.824609e-01	0.235
MET activates PTK2 signaling	R-HSA-8874081	5.860347e-01	0.232
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.860347e-01	0.232
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.860347e-01	0.232
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.860347e-01	0.232
Mitochondrial biogenesis	R-HSA-1592230	5.890801e-01	0.230
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.928914e-01	0.227
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.928914e-01	0.227
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.928914e-01	0.227
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.928914e-01	0.227
Passive transport by Aquaporins	R-HSA-432047	5.928914e-01	0.227
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	5.928914e-01	0.227
Response to metal ions	R-HSA-5660526	5.928914e-01	0.227
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.067089e-01	0.217
Maturation of hRSV A proteins	R-HSA-9828806	6.067089e-01	0.217
Insulin processing	R-HSA-264876	6.067089e-01	0.217
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.092375e-01	0.215
TRIF-mediated programmed cell death	R-HSA-2562578	6.134247e-01	0.212
IFNG signaling activates MAPKs	R-HSA-9732724	6.134247e-01	0.212
SOS-mediated signalling	R-HSA-112412	6.134247e-01	0.212
PTK6 Expression	R-HSA-8849473	6.134247e-01	0.212
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.134247e-01	0.212
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.134247e-01	0.212
MET activates PI3K/AKT signaling	R-HSA-8851907	6.134247e-01	0.212
VLDL clearance	R-HSA-8964046	6.134247e-01	0.212
Netrin mediated repulsion signals	R-HSA-418886	6.134247e-01	0.212
NGF-stimulated transcription	R-HSA-9031628	6.142536e-01	0.212
Metal ion SLC transporters	R-HSA-425410	6.142536e-01	0.212
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.180753e-01	0.209
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.180753e-01	0.209
Specification of primordial germ cells	R-HSA-9827857	6.180753e-01	0.209
Uptake and function of anthrax toxins	R-HSA-5210891	6.180753e-01	0.209
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.180753e-01	0.209
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.187663e-01	0.208
Gastrulation	R-HSA-9758941	6.209428e-01	0.207
tRNA Aminoacylation	R-HSA-379724	6.257045e-01	0.204
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.266840e-01	0.203
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.320213e-01	0.199
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	6.360561e-01	0.197
G beta:gamma signalling through PLC beta	R-HSA-418217	6.420420e-01	0.192
Synaptic adhesion-like molecules	R-HSA-8849932	6.420420e-01	0.192
Presynaptic function of Kainate receptors	R-HSA-500657	6.420420e-01	0.192
Polo-like kinase mediated events	R-HSA-156711	6.420420e-01	0.192
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.420420e-01	0.192
Platelet sensitization by LDL	R-HSA-432142	6.420420e-01	0.192
Apoptotic factor-mediated response	R-HSA-111471	6.420420e-01	0.192
Tie2 Signaling	R-HSA-210993	6.420420e-01	0.192
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.420420e-01	0.192
Parasitic Infection Pathways	R-HSA-9824443	6.444228e-01	0.191
Leishmania infection	R-HSA-9658195	6.444228e-01	0.191
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.459491e-01	0.190
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.459491e-01	0.190
Reverse Transcription of HIV RNA	R-HSA-162589	6.484854e-01	0.188
Minus-strand DNA synthesis	R-HSA-164516	6.484854e-01	0.188
phospho-PLA2 pathway	R-HSA-111995	6.484854e-01	0.188
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.484854e-01	0.188
Regulation by c-FLIP	R-HSA-3371378	6.484854e-01	0.188
Dimerization of procaspase-8	R-HSA-69416	6.484854e-01	0.188
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.484854e-01	0.188
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.484854e-01	0.188
TGFBR3 PTM regulation	R-HSA-9839383	6.484854e-01	0.188
Adrenoceptors	R-HSA-390696	6.484854e-01	0.188
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.484854e-01	0.188
Activated NTRK2 signals through FYN	R-HSA-9032500	6.484854e-01	0.188
Ca2+ pathway	R-HSA-4086398	6.486781e-01	0.188
Nuclear signaling by ERBB4	R-HSA-1251985	6.522372e-01	0.186
Heme signaling	R-HSA-9707616	6.530176e-01	0.185
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	6.644982e-01	0.178
Germ layer formation at gastrulation	R-HSA-9754189	6.648051e-01	0.177
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.648051e-01	0.177
Diseases of hemostasis	R-HSA-9671793	6.648051e-01	0.177
Other interleukin signaling	R-HSA-449836	6.648051e-01	0.177
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.648051e-01	0.177
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.682167e-01	0.175
FCERI mediated NF-kB activation	R-HSA-2871837	6.743531e-01	0.171
Lipophagy	R-HSA-9613354	6.803681e-01	0.167
CASP8 activity is inhibited	R-HSA-5218900	6.803681e-01	0.167
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.803681e-01	0.167
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.803681e-01	0.167
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.803681e-01	0.167
Regulation of signaling by NODAL	R-HSA-1433617	6.803681e-01	0.167
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.803681e-01	0.167
Regulation of CDH11 gene transcription	R-HSA-9762293	6.803681e-01	0.167
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.803681e-01	0.167
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.803681e-01	0.167
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.803681e-01	0.167
Molecules associated with elastic fibres	R-HSA-2129379	6.823293e-01	0.166
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.836846e-01	0.165
Ion channel transport	R-HSA-983712	6.860500e-01	0.164
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.863858e-01	0.163
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.863858e-01	0.163
Signaling by NODAL	R-HSA-1181150	6.863858e-01	0.163
VxPx cargo-targeting to cilium	R-HSA-5620916	6.863858e-01	0.163
Creatine metabolism	R-HSA-71288	6.863858e-01	0.163
Toll-like Receptor Cascades	R-HSA-168898	7.008582e-01	0.154
Stimuli-sensing channels	R-HSA-2672351	7.023405e-01	0.153
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.068112e-01	0.151
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.068112e-01	0.151
Lagging Strand Synthesis	R-HSA-69186	7.068112e-01	0.151
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	7.068112e-01	0.151
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.068112e-01	0.151
Integrin cell surface interactions	R-HSA-216083	7.077589e-01	0.150
MAPK3 (ERK1) activation	R-HSA-110056	7.093607e-01	0.149
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.093607e-01	0.149
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.093607e-01	0.149
DNA replication initiation	R-HSA-68952	7.093607e-01	0.149
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.093607e-01	0.149
Signal attenuation	R-HSA-74749	7.093607e-01	0.149
CASP4 inflammasome assembly	R-HSA-9948001	7.093607e-01	0.149
Defective factor IX causes hemophilia B	R-HSA-9668250	7.093607e-01	0.149
Formation of apoptosome	R-HSA-111458	7.093607e-01	0.149
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.093607e-01	0.149
Regulation of the apoptosome activity	R-HSA-9627069	7.093607e-01	0.149
Interleukin-27 signaling	R-HSA-9020956	7.093607e-01	0.149
Maturation of spike protein	R-HSA-9683686	7.093607e-01	0.149
Signaling by Leptin	R-HSA-2586552	7.093607e-01	0.149
tRNA processing	R-HSA-72306	7.113803e-01	0.148
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.158490e-01	0.145
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	7.158490e-01	0.145
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.218051e-01	0.142
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.261133e-01	0.139
Glutathione synthesis and recycling	R-HSA-174403	7.261133e-01	0.139
Serine metabolism	R-HSA-977347	7.261133e-01	0.139
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.261133e-01	0.139
Ribavirin ADME	R-HSA-9755088	7.261133e-01	0.139
Resolution of D-Loop Structures	R-HSA-5693537	7.315511e-01	0.136
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.357251e-01	0.133
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.357251e-01	0.133
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.357251e-01	0.133
Ionotropic activity of kainate receptors	R-HSA-451306	7.357251e-01	0.133
Signaling by APC mutants	R-HSA-4839744	7.357251e-01	0.133
Conjugation of benzoate with glycine	R-HSA-177135	7.357251e-01	0.133
RHOBTB3 ATPase cycle	R-HSA-9706019	7.357251e-01	0.133
Suppression of apoptosis	R-HSA-9635465	7.357251e-01	0.133
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.357251e-01	0.133
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.357251e-01	0.133
Dissolution of Fibrin Clot	R-HSA-75205	7.357251e-01	0.133
Cardiac conduction	R-HSA-5576891	7.383193e-01	0.132
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.443278e-01	0.128
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.443278e-01	0.128
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.465614e-01	0.127
Signal amplification	R-HSA-392518	7.465614e-01	0.127
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.465614e-01	0.127
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.465614e-01	0.127
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.501359e-01	0.125
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.533226e-01	0.123
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.596994e-01	0.119
PI3K events in ERBB4 signaling	R-HSA-1250342	7.596994e-01	0.119
Signaling by GSK3beta mutants	R-HSA-5339716	7.596994e-01	0.119
Proton-coupled monocarboxylate transport	R-HSA-433692	7.596994e-01	0.119
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.596994e-01	0.119
Plasmalogen biosynthesis	R-HSA-75896	7.596994e-01	0.119
Signaling by AXIN mutants	R-HSA-4839735	7.596994e-01	0.119
Signaling by AMER1 mutants	R-HSA-4839748	7.596994e-01	0.119
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.596994e-01	0.119
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.596994e-01	0.119
Activation of RAC1	R-HSA-428540	7.596994e-01	0.119
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.596994e-01	0.119
Regulation of PTEN mRNA translation	R-HSA-8943723	7.614931e-01	0.118
Extension of Telomeres	R-HSA-180786	7.615233e-01	0.118
Triglyceride metabolism	R-HSA-8979227	7.615233e-01	0.118
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.615233e-01	0.118
SLC transporter disorders	R-HSA-5619102	7.644346e-01	0.117
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.697751e-01	0.114
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.745603e-01	0.111
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.776497e-01	0.109
Mitochondrial RNA degradation	R-HSA-9836573	7.776497e-01	0.109
Interferon alpha/beta signaling	R-HSA-909733	7.803878e-01	0.108
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.815000e-01	0.107
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.815000e-01	0.107
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.815000e-01	0.107
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.815000e-01	0.107
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.815000e-01	0.107
GRB2 events in EGFR signaling	R-HSA-179812	7.815000e-01	0.107
Acetylation	R-HSA-156582	7.815000e-01	0.107
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.815000e-01	0.107
Conjugation of salicylate with glycine	R-HSA-177128	7.815000e-01	0.107
RUNX3 regulates p14-ARF	R-HSA-8951936	7.815000e-01	0.107
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.815000e-01	0.107
Maple Syrup Urine Disease	R-HSA-9865114	7.815000e-01	0.107
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.815000e-01	0.107
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.815000e-01	0.107
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.815000e-01	0.107
Interleukin-35 Signalling	R-HSA-8984722	7.815000e-01	0.107
OAS antiviral response	R-HSA-8983711	7.815000e-01	0.107
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.821106e-01	0.107
Integration of energy metabolism	R-HSA-163685	7.839041e-01	0.106
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.850825e-01	0.105
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.876846e-01	0.104
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.928392e-01	0.101
Tight junction interactions	R-HSA-420029	7.928392e-01	0.101
Laminin interactions	R-HSA-3000157	7.928392e-01	0.101
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.928392e-01	0.101
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.928392e-01	0.101
Rab regulation of trafficking	R-HSA-9007101	7.955568e-01	0.099
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.988191e-01	0.098
MET promotes cell motility	R-HSA-8875878	7.999691e-01	0.097
Elastic fibre formation	R-HSA-1566948	7.999691e-01	0.097
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.999691e-01	0.097
Signaling by FGFR2 in disease	R-HSA-5655253	8.000294e-01	0.097
Adenylate cyclase activating pathway	R-HSA-170660	8.013241e-01	0.096
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.013241e-01	0.096
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.013241e-01	0.096
Processing of SMDT1	R-HSA-8949664	8.013241e-01	0.096
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.013241e-01	0.096
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.013241e-01	0.096
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.013241e-01	0.096
Interleukin-6 signaling	R-HSA-1059683	8.013241e-01	0.096
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.071041e-01	0.093
TRP channels	R-HSA-3295583	8.071041e-01	0.093
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.071041e-01	0.093
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.071041e-01	0.093
Sphingolipid catabolism	R-HSA-9845614	8.071041e-01	0.093
The phototransduction cascade	R-HSA-2514856	8.105192e-01	0.091
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.173556e-01	0.088
Removal of the Flap Intermediate	R-HSA-69166	8.193506e-01	0.087
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.193506e-01	0.087
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.193506e-01	0.087
CRMPs in Sema3A signaling	R-HSA-399956	8.193506e-01	0.087
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.193506e-01	0.087
Hydrolysis of LPC	R-HSA-1483115	8.193506e-01	0.087
Physiological factors	R-HSA-5578768	8.193506e-01	0.087
Malate-aspartate shuttle	R-HSA-9856872	8.193506e-01	0.087
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.193506e-01	0.087
Non-canonical inflammasome activation	R-HSA-9686114	8.193506e-01	0.087
Acyl chain remodeling of CL	R-HSA-1482798	8.193506e-01	0.087
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.204871e-01	0.086
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.204871e-01	0.086
Signaling by FGFR3 in disease	R-HSA-5655332	8.204871e-01	0.086
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.205548e-01	0.086
Neddylation	R-HSA-8951664	8.218414e-01	0.085
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.229316e-01	0.085
Diseases of Immune System	R-HSA-5260271	8.229316e-01	0.085
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.330307e-01	0.079
Telomere Extension By Telomerase	R-HSA-171319	8.330307e-01	0.079
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.330307e-01	0.079
Erythropoietin activates RAS	R-HSA-9027284	8.357424e-01	0.078
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.357424e-01	0.078
Beta-catenin phosphorylation cascade	R-HSA-196299	8.357424e-01	0.078
SHC1 events in EGFR signaling	R-HSA-180336	8.357424e-01	0.078
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.357424e-01	0.078
G beta:gamma signalling through BTK	R-HSA-8964315	8.357424e-01	0.078
Processive synthesis on the lagging strand	R-HSA-69183	8.357424e-01	0.078
p38MAPK events	R-HSA-171007	8.357424e-01	0.078
Protein repair	R-HSA-5676934	8.357424e-01	0.078
Dopamine clearance from the synaptic cleft	R-HSA-379401	8.357424e-01	0.078
Lysosphingolipid and LPA receptors	R-HSA-419408	8.357424e-01	0.078
Other semaphorin interactions	R-HSA-416700	8.357424e-01	0.078
Signaling by Activin	R-HSA-1502540	8.357424e-01	0.078
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.364234e-01	0.078
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.436043e-01	0.074
Intra-Golgi traffic	R-HSA-6811438	8.436043e-01	0.074
Downstream signaling of activated FGFR3	R-HSA-5654708	8.447771e-01	0.073
Extracellular matrix organization	R-HSA-1474244	8.477586e-01	0.072
Asparagine N-linked glycosylation	R-HSA-446203	8.491374e-01	0.071
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.506478e-01	0.070
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.506478e-01	0.070
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.506478e-01	0.070
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.506478e-01	0.070
Attachment and Entry	R-HSA-9678110	8.506478e-01	0.070
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.557676e-01	0.068
Downstream signaling of activated FGFR4	R-HSA-5654716	8.557676e-01	0.068
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.557676e-01	0.068
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.599574e-01	0.066
Innate Immune System	R-HSA-168249	8.617505e-01	0.065
COPII-mediated vesicle transport	R-HSA-204005	8.619443e-01	0.065
TBC/RABGAPs	R-HSA-8854214	8.621506e-01	0.064
G beta:gamma signalling through CDC42	R-HSA-8964616	8.642014e-01	0.063
Fibronectin matrix formation	R-HSA-1566977	8.642014e-01	0.063
tRNA modification in the mitochondrion	R-HSA-6787450	8.642014e-01	0.063
Galactose catabolism	R-HSA-70370	8.642014e-01	0.063
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.642014e-01	0.063
Coenzyme A biosynthesis	R-HSA-196783	8.642014e-01	0.063
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.660425e-01	0.062
Amine ligand-binding receptors	R-HSA-375280	8.706780e-01	0.060
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.719024e-01	0.060
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.756414e-01	0.058
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.757585e-01	0.058
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.765258e-01	0.057
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.765258e-01	0.057
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.765258e-01	0.057
Choline catabolism	R-HSA-6798163	8.765258e-01	0.057
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.765258e-01	0.057
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.765258e-01	0.057
Amino acid transport across the plasma membrane	R-HSA-352230	8.791009e-01	0.056
Diseases of carbohydrate metabolism	R-HSA-5663084	8.822135e-01	0.054
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.859458e-01	0.053
Diseases of DNA repair	R-HSA-9675135	8.863436e-01	0.052
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.866092e-01	0.052
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.877323e-01	0.052
Mismatch Repair	R-HSA-5358508	8.877323e-01	0.052
Adipogenesis	R-HSA-9843745	8.901159e-01	0.051
Acyl chain remodelling of PC	R-HSA-1482788	8.929614e-01	0.049
Miscellaneous transport and binding events	R-HSA-5223345	8.929614e-01	0.049
Glutamate and glutamine metabolism	R-HSA-8964539	8.929614e-01	0.049
PI-3K cascade:FGFR3	R-HSA-5654710	8.979223e-01	0.047
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.979223e-01	0.047
Amino Acid conjugation	R-HSA-156587	8.979223e-01	0.047
Conjugation of carboxylic acids	R-HSA-159424	8.979223e-01	0.047
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.979223e-01	0.047
O2/CO2 exchange in erythrocytes	R-HSA-1480926	8.979223e-01	0.047
Methionine salvage pathway	R-HSA-1237112	8.979223e-01	0.047
Specification of the neural plate border	R-HSA-9834899	8.979223e-01	0.047
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	8.979223e-01	0.047
Mitochondrial protein import	R-HSA-1268020	8.986267e-01	0.046
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.986267e-01	0.046
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.007546e-01	0.045
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.007546e-01	0.045
Formation of the cornified envelope	R-HSA-6809371	9.062085e-01	0.043
PI-3K cascade:FGFR4	R-HSA-5654720	9.071880e-01	0.042
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.071880e-01	0.042
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.071880e-01	0.042
Acyl chain remodelling of PI	R-HSA-1482922	9.071880e-01	0.042
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.071880e-01	0.042
Neurotransmitter release cycle	R-HSA-112310	9.075326e-01	0.042
Transferrin endocytosis and recycling	R-HSA-917977	9.080156e-01	0.042
Acyl chain remodelling of PE	R-HSA-1482839	9.080156e-01	0.042
Downstream signaling of activated FGFR2	R-HSA-5654696	9.080156e-01	0.042
Downstream signaling of activated FGFR1	R-HSA-5654687	9.080156e-01	0.042
Metabolism of amino acids and derivatives	R-HSA-71291	9.123797e-01	0.040
PI3K Cascade	R-HSA-109704	9.126756e-01	0.040
RUNX2 regulates bone development	R-HSA-8941326	9.147768e-01	0.039
G1/S-Specific Transcription	R-HSA-69205	9.147768e-01	0.039
FGFR2 mutant receptor activation	R-HSA-1839126	9.147768e-01	0.039
G-protein activation	R-HSA-202040	9.156131e-01	0.038
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.156131e-01	0.038
Signalling to RAS	R-HSA-167044	9.156131e-01	0.038
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.156131e-01	0.038
Zygotic genome activation (ZGA)	R-HSA-9819196	9.156131e-01	0.038
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.156131e-01	0.038
Acyl chain remodelling of PG	R-HSA-1482925	9.156131e-01	0.038
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.203103e-01	0.036
TRAF6 mediated IRF7 activation	R-HSA-933541	9.210691e-01	0.036
Collagen chain trimerization	R-HSA-8948216	9.210691e-01	0.036
Mitochondrial calcium ion transport	R-HSA-8949215	9.232739e-01	0.035
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.232739e-01	0.035
Attachment and Entry	R-HSA-9694614	9.232739e-01	0.035
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.250320e-01	0.034
SLC-mediated transport of amino acids	R-HSA-9958863	9.250371e-01	0.034
tRNA processing in the mitochondrion	R-HSA-6785470	9.269218e-01	0.033
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.283820e-01	0.032
Parasite infection	R-HSA-9664407	9.283820e-01	0.032
Leishmania phagocytosis	R-HSA-9664417	9.283820e-01	0.032
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.286965e-01	0.032
Collagen formation	R-HSA-1474290	9.289243e-01	0.032
PI-3K cascade:FGFR1	R-HSA-5654689	9.302396e-01	0.031
RAF-independent MAPK1/3 activation	R-HSA-112409	9.302396e-01	0.031
Ethanol oxidation	R-HSA-71384	9.302396e-01	0.031
Cellular hexose transport	R-HSA-189200	9.302396e-01	0.031
Platelet homeostasis	R-HSA-418346	9.303847e-01	0.031
Cytoprotection by HMOX1	R-HSA-9707564	9.323990e-01	0.030
Free fatty acids regulate insulin secretion	R-HSA-400451	9.365734e-01	0.028
Carnitine shuttle	R-HSA-200425	9.365734e-01	0.028
Formation of the ureteric bud	R-HSA-9830674	9.365734e-01	0.028
Mitochondrial mRNA modification	R-HSA-9937008	9.365734e-01	0.028
Interleukin-20 family signaling	R-HSA-8854691	9.365734e-01	0.028
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.374187e-01	0.028
rRNA processing in the mitochondrion	R-HSA-8868766	9.374187e-01	0.028
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.374187e-01	0.028
Degradation of the extracellular matrix	R-HSA-1474228	9.406321e-01	0.027
ECM proteoglycans	R-HSA-3000178	9.415179e-01	0.026
Metabolism of cofactors	R-HSA-8978934	9.415179e-01	0.026
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.421145e-01	0.026
Maturation of spike protein	R-HSA-9694548	9.421145e-01	0.026
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.423324e-01	0.026
Thromboxane signalling through TP receptor	R-HSA-428930	9.423324e-01	0.026
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.423324e-01	0.026
Complex III assembly	R-HSA-9865881	9.423324e-01	0.026
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.423324e-01	0.026
Interleukin-6 family signaling	R-HSA-6783589	9.423324e-01	0.026
IRS-mediated signalling	R-HSA-112399	9.457675e-01	0.024
Scavenging by Class A Receptors	R-HSA-3000480	9.464740e-01	0.024
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.464740e-01	0.024
Interferon gamma signaling	R-HSA-877300	9.474426e-01	0.023
PI-3K cascade:FGFR2	R-HSA-5654695	9.475688e-01	0.023
G protein gated Potassium channels	R-HSA-1296059	9.475688e-01	0.023
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.475688e-01	0.023
Activation of G protein gated Potassium channels	R-HSA-1296041	9.475688e-01	0.023
Activation of GABAB receptors	R-HSA-991365	9.505193e-01	0.022
GABA B receptor activation	R-HSA-977444	9.505193e-01	0.022
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.517491e-01	0.021
Leishmania parasite growth and survival	R-HSA-9664433	9.517491e-01	0.021
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.523300e-01	0.021
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.523300e-01	0.021
Cell surface interactions at the vascular wall	R-HSA-202733	9.535436e-01	0.021
RAB geranylgeranylation	R-HSA-8873719	9.560128e-01	0.020
Surfactant metabolism	R-HSA-5683826	9.577509e-01	0.019
IRS-related events triggered by IGF1R	R-HSA-2428928	9.590042e-01	0.018
Collagen degradation	R-HSA-1442490	9.590042e-01	0.018
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.601136e-01	0.018
Insulin receptor recycling	R-HSA-77387	9.605953e-01	0.017
Thyroxine biosynthesis	R-HSA-209968	9.641742e-01	0.016
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.641742e-01	0.016
Glucagon-type ligand receptors	R-HSA-420092	9.641742e-01	0.016
Regulation of gene expression in beta cells	R-HSA-210745	9.641742e-01	0.016
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.644230e-01	0.016
Insulin receptor signalling cascade	R-HSA-74751	9.668722e-01	0.015
IGF1R signaling cascade	R-HSA-2428924	9.668722e-01	0.015
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.674282e-01	0.014
Neurotransmitter clearance	R-HSA-112311	9.674282e-01	0.014
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.691617e-01	0.014
Cargo concentration in the ER	R-HSA-5694530	9.703869e-01	0.013
Chemokine receptors bind chemokines	R-HSA-380108	9.716639e-01	0.012
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.718377e-01	0.012
Signaling by WNT in cancer	R-HSA-4791275	9.730770e-01	0.012
Inwardly rectifying K+ channels	R-HSA-1296065	9.730770e-01	0.012
Azathioprine ADME	R-HSA-9748787	9.738579e-01	0.012
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.751646e-01	0.011
Cardiogenesis	R-HSA-9733709	9.755228e-01	0.011
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.755228e-01	0.011
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.770056e-01	0.010
FCERI mediated MAPK activation	R-HSA-2871796	9.770698e-01	0.010
Effects of PIP2 hydrolysis	R-HSA-114508	9.777466e-01	0.010
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.777466e-01	0.010
Heme degradation	R-HSA-189483	9.777466e-01	0.010
G alpha (i) signalling events	R-HSA-418594	9.780406e-01	0.010
Nucleotide biosynthesis	R-HSA-8956320	9.794989e-01	0.009
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.816068e-01	0.008
PI Metabolism	R-HSA-1483255	9.822575e-01	0.008
Paracetamol ADME	R-HSA-9753281	9.825835e-01	0.008
NCAM1 interactions	R-HSA-419037	9.847977e-01	0.007
Lysine catabolism	R-HSA-71064	9.847977e-01	0.007
Metabolism of folate and pterines	R-HSA-196757	9.847977e-01	0.007
Citric acid cycle (TCA cycle)	R-HSA-71403	9.851467e-01	0.006
Dectin-2 family	R-HSA-5621480	9.852153e-01	0.006
Signaling by Insulin receptor	R-HSA-74752	9.872566e-01	0.006
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.874354e-01	0.005
GABA receptor activation	R-HSA-977443	9.884520e-01	0.005
Glutathione conjugation	R-HSA-156590	9.884520e-01	0.005
Tryptophan catabolism	R-HSA-71240	9.885774e-01	0.005
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.889835e-01	0.005
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.910122e-01	0.004
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.914177e-01	0.004
G alpha (q) signalling events	R-HSA-416476	9.915342e-01	0.004
PPARA activates gene expression	R-HSA-1989781	9.925573e-01	0.003
Methylation	R-HSA-156581	9.929073e-01	0.003
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.933809e-01	0.003
G alpha (s) signalling events	R-HSA-418555	9.933973e-01	0.003
Nicotinate metabolism	R-HSA-196807	9.935488e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.937988e-01	0.003
Role of phospholipids in phagocytosis	R-HSA-2029485	9.937988e-01	0.003
Peptide hormone metabolism	R-HSA-2980736	9.945832e-01	0.002
Synthesis of PC	R-HSA-1483191	9.946715e-01	0.002
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.949845e-01	0.002
Plasma lipoprotein remodeling	R-HSA-8963899	9.951560e-01	0.002
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.959970e-01	0.002
Aspirin ADME	R-HSA-9749641	9.961054e-01	0.002
Complex IV assembly	R-HSA-9864848	9.963611e-01	0.002
Cytosolic sulfonation of small molecules	R-HSA-156584	9.963611e-01	0.002
Branched-chain amino acid catabolism	R-HSA-70895	9.963611e-01	0.002
Amino acids regulate mTORC1	R-HSA-9639288	9.969930e-01	0.001
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.970060e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.974514e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.974514e-01	0.001
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.976378e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.977413e-01	0.001
Synthesis of PA	R-HSA-1483166	9.979468e-01	0.001
Regulation of beta-cell development	R-HSA-186712	9.983035e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.984579e-01	0.001
Sulfur amino acid metabolism	R-HSA-1614635	9.988203e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.988418e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.989472e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.989534e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.991644e-01	0.000
Kidney development	R-HSA-9830369	9.992093e-01	0.000
Keratinization	R-HSA-6805567	9.992347e-01	0.000
Transport of small molecules	R-HSA-382551	9.992783e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.993404e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.994603e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.994704e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.996786e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.997486e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.997486e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997735e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.998441e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.998733e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998849e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998879e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.998898e-01	0.000
FCGR activation	R-HSA-2029481	9.999455e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999628e-01	0.000
Potassium Channels	R-HSA-1296071	9.999628e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999670e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999693e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999842e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999861e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999878e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999903e-01	0.000
Drug ADME	R-HSA-9748784	9.999915e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999937e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999941e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999979e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999982e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999983e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999985e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999987e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999989e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999993e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999999e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999999e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000