MEK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14545 S327 Sugiyama TRAFD1 FLN29 DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O75676 S196 EPSD RPS6KA4 MSK2 VLTDFGLSKEFLTEEKERtFsFCGTIEYMAPEIIRSKTGHG
O75676 S343 EPSD RPS6KA4 MSK2 RsELDVGNFAEEFTRLEPVysPPGsPPPGDPRIFQGYsFVA
O75676 S347 EPSD RPS6KA4 MSK2 DVGNFAEEFTRLEPVysPPGsPPPGDPRIFQGYsFVAPsIL
O75676 S360 EPSD RPS6KA4 MSK2 PVysPPGsPPPGDPRIFQGYsFVAPsILFDHNNAVMTDGLE
O75676 T568 EPSD RPS6KA4 MSK2 KIIDFGFARLRPQSPGVPMQtPCFTLQYAAPELLAQQGYDE
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04049 S338 EPSD|PSP RAF1 RAF RAPVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsG
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 Y364 Sugiyama ALDOA ALDA tPsGQAGAAAsEsLFVsNHAy____________________
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S74 EPSD|PSP KRT8 CYK8 YGGASGMGGITAVtVNQSLLsPLVLEVDPNIQAVRTQEKEQ
P06401 S294 PSP PGR NR3C3 RFSAPRVALVEQDAPMAPGRsPLATTVMDFIHVPILPLNHA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10809 T422 Sugiyama HSPD1 HSP60 AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P12956 S77 PSP XRCC6 G22P1 LTPFDMSIQCIQSVYISKIIssDRDLLAVVFYGTEKDKNSV
P12956 S78 PSP XRCC6 G22P1 TPFDMSIQCIQSVYISKIIssDRDLLAVVFYGTEKDKNSVN
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13797 T117 Sugiyama PLS3 INRKEGICALGGTsELssEGtQHsysEEEKyAFVNWINKAL
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P17066 T224 Sugiyama HSPA6 HSP70B' GGTFDVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFM
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17542 S122 SIGNOR|EPSD|PSP TAL1 BHLHA17 SCL TCL5 APAPASVTAELPGDGRMVQLsPPALAAPAAPGRALLYSLSQ
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 Y26 Sugiyama PGAM1 PGAMA CDABP0006 LVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALR
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27361 T202 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK3 ERK1 PRKM3 ICDFGLARIADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGY
P27361 T207 EPSD|PSP MAPK3 ERK1 PRKM3 LARIADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGYTKSID
P27361 Y204 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK3 ERK1 PRKM3 DFGLARIADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGYTK
P27361 Y210 EPSD|PSP MAPK3 ERK1 PRKM3 IADPEHDHtGFLtEyVAtRWyRAPEIMLNSKGYTKSIDIWS
P28482 T185 GPS6|SIGNOR|ELM|EPSD|PSP MAPK1 ERK2 PRKM1 PRKM2 ICDFGLARVADPDHDHtGFLtEyVAtRWyRAPEIMLNSKGY
P28482 Y187 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK1 ERK2 PRKM1 PRKM2 DFGLARVADPDHDHtGFLtEyVAtRWyRAPEIMLNSKGYTK
P30086 T167 Sugiyama PEBP1 PBP PEBP GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P32121 T382 SIGNOR ARRB2 ARB2 ARR2 APETDVPVDTNLIEFDTNYAtDDDIVFEDFARLRLKGMKDD
P34931 T224 Sugiyama HSPA1L GGTFDVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFV
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35568 S307 SIGNOR IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P36507 S222 Sugiyama MAP2K2 MEK2 MKK2 PRKMK2 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGT
P36507 S226 Sugiyama MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45984 S407 ELM MAPK9 JNK2 PRKM9 SAPK1A PSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR___
P45984 T404 ELM MAPK9 JNK2 PRKM9 SAPK1A NATPSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P48741 T224 Sugiyama HSPA7 HSP70B GGTFDVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFM
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49841 Y216 SIGNOR|ELM|iPTMNet|EPSD|PSP GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P53779 T221 ELM MAPK10 JNK3 JNK3A PRKM10 SAPK1B CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55211 T125 SIGNOR|iPTMNet|EPSD CASP9 MCH6 NLtPVVLRPEIRKPEVLRPEtPRPVDIGSGGFGDVGALEsL
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P85037 S445 Sugiyama FOXK1 MNF GLMsPRsGGLQtPECLsREGsPIPHDPEFGsKLASVPEYRY
Q00613 S326 EPSD|PSP HSF1 HSTF1 QsPRVEEAsPGRPssVDtLLsPtALIDsILREsEPAPAsVT
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q02750 S218 ELM|Sugiyama MAP2K1 MEK1 PRKMK1 VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGT
Q02750 S222 Sugiyama MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q02750 S24 ELM MAP2K1 MEK1 PRKMK1 KKPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELDE
Q02750 S25 ELM MAP2K1 MEK1 PRKMK1 KPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELDEQ
Q02750 S298 ELM MAP2K1 MEK1 PRKMK1 QVEGDAAEtPPRPRtPGRPLssyGMDsRPPMAIFELLDYIV
Q02750 S304 SIGNOR|EPSD MAP2K1 MEK1 PRKMK1 AEtPPRPRtPGRPLssyGMDsRPPMAIFELLDYIVNEPPPK
Q02750 T23 ELM MAP2K1 MEK1 PRKMK1 KKKPTPIQLNPAPDGSAVNGtssAETNLEALQKKLEELELD
Q06830 T166 Sugiyama PRDX1 PAGA PAGB TDPX2 DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13009 S329 SIGNOR TIAM1 SNsMQGRRAKttQDVNAGEGsEFADsGIEGAtTDTDLLSRR
Q13112 S410 Sugiyama CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13148 T153 PSP TARDBP TDP43 VQVKKDLKTGHSKGFGFVRFtEyETQVKVMSQRHMIDGRWC
Q13148 Y155 PSP TARDBP TDP43 VKKDLKTGHSKGFGFVRFtEyETQVKVMSQRHMIDGRWCDC
Q13158 S194 Sugiyama FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13158 S197 Sugiyama FADD MORT1 GIG3 VQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS_________
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q16539 T180 ELM MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 ELM MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q27J81 T1206 Sugiyama INF2 C14orf151 C14orf173 DtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKKRP
Q6N021 S1107 SIGNOR TET2 KIAA1546 Nbla00191 SSEKTPTKRTAASVLNNFIEsPsKLLDtPIKNLLDTPVKTQ
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6UN15 S496 Sugiyama FIP1L1 FIP1 RHE DRERERTRERERERDHsPtPsVFNsDEERyRYREYAERGYE
Q6ZN28 Y673 PSP MACC1 VLTLVSEKVYDWKVLADVLGySHLSLEDFDQIQADKESEKV
Q6ZN28 Y695 PSP MACC1 HLSLEDFDQIQADKESEKVSyVIKKLKEDCHTERNTRKFLY
Q6ZN28 Y793 PSP MACC1 RGNTGDVAVEMMWKPAYDFLyTWSAHYGNNYRDVLQDLQSA
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 S205 Sugiyama CPSF7 IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q96I24 T561 Sugiyama FUBP3 FBP3 PDYtMAWAEYYRQQVAFYGQtLGQAQAHsQEQ_________
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9HAP2 Y222 PSP MLXIP BHLHE36 KIAA0867 MIR MONDOA EAITTEGKYWKSRIEIVIREyHKWRTYFKKRLQQHKDEDLS
Q9NPI6 S525 Sugiyama DCP1A SMIF SVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKs
Q9NR19 S30 Sugiyama ACSS2 ACAS2 sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NVD7 S14 EPSD PARVA MXRA2 _______MAtsPQKsPsVPKsPtPKsPPSRKKDDsFLGKLG
Q9NVD7 S19 EPSD PARVA MXRA2 __MAtsPQKsPsVPKsPtPKsPPSRKKDDsFLGKLGGtLAR
Q9NVD7 S4 EPSD PARVA MXRA2 _________________MAtsPQKsPsVPKsPtPKsPPSRK
Q9NVD7 S8 EPSD PARVA MXRA2 _____________MAtsPQKsPsVPKsPtPKsPPSRKKDDs
Q9NVD7 T16 EPSD PARVA MXRA2 _____MAtsPQKsPsVPKsPtPKsPPSRKKDDsFLGKLGGt
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S323 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDKK
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9UQ35 T328 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2B0 T79 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 4.814140e-10 9.317 0 0
Cell Cycle R-HSA-1640170 1.652153e-09 8.782 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.550304e-09 8.342 0 0
Mitotic Prometaphase R-HSA-68877 1.637429e-08 7.786 0 0
Separation of Sister Chromatids R-HSA-2467813 2.143189e-08 7.669 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.693526e-08 7.433 0 0
M Phase R-HSA-68886 4.368814e-08 7.360 0 0
Regulation of CDH1 Function R-HSA-9764561 2.814257e-07 6.551 0 0
Mitotic Anaphase R-HSA-68882 5.492828e-07 6.260 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.005655e-07 6.221 0 0
Aggrephagy R-HSA-9646399 1.025367e-06 5.989 0 0
Cell-Cell communication R-HSA-1500931 1.489675e-06 5.827 0 0
Cell Cycle Checkpoints R-HSA-69620 2.326193e-06 5.633 0 0
Selective autophagy R-HSA-9663891 2.826162e-06 5.549 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.347098e-06 5.197 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.347098e-06 5.197 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.355849e-06 5.133 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.355849e-06 5.133 0 0
G2/M Transition R-HSA-69275 6.937865e-06 5.159 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.147824e-06 5.089 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.226937e-06 5.085 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.881471e-06 5.052 1 0
Cell junction organization R-HSA-446728 9.829586e-06 5.007 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.097156e-05 4.960 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.587081e-05 4.799 0 0
Membrane Trafficking R-HSA-199991 2.006447e-05 4.698 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.156753e-05 4.666 0 0
Recycling pathway of L1 R-HSA-437239 2.721383e-05 4.565 0 0
Adherens junctions interactions R-HSA-418990 3.471706e-05 4.459 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.334534e-05 4.363 0 0
Cell-cell junction organization R-HSA-421270 5.505647e-05 4.259 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.761130e-05 4.239 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.211279e-04 3.917 0 0
Signal Transduction R-HSA-162582 1.301728e-04 3.885 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.387474e-04 3.858 0 0
Regulation of PTEN localization R-HSA-8948747 1.626077e-04 3.789 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.721682e-04 3.764 0 0
Gap junction trafficking and regulation R-HSA-157858 1.679457e-04 3.775 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.797044e-04 3.745 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.514916e-04 3.599 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.514916e-04 3.599 0 0
Metalloprotease DUBs R-HSA-5689901 2.380545e-04 3.623 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.376335e-04 3.624 0 0
Mitophagy R-HSA-5205647 2.566435e-04 3.591 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.514916e-04 3.599 0 0
Autophagy R-HSA-9612973 2.272918e-04 3.643 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.531447e-04 3.597 0 0
Negative regulation of MET activity R-HSA-6807004 2.960591e-04 3.529 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.212535e-04 3.493 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.549577e-04 3.450 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.613902e-04 3.442 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.263345e-04 3.370 0 0
Late endosomal microautophagy R-HSA-9615710 4.288863e-04 3.368 0 0
Translesion synthesis by REV1 R-HSA-110312 4.263345e-04 3.370 0 0
p75NTR signals via NF-kB R-HSA-193639 4.263345e-04 3.370 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.263345e-04 3.370 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.529245e-04 3.344 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.663762e-04 3.331 0 0
Macroautophagy R-HSA-1632852 4.618849e-04 3.335 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.347865e-04 3.272 0 0
Translesion synthesis by POLI R-HSA-5656121 5.564712e-04 3.255 0 0
Activation of the pre-replicative complex R-HSA-68962 5.148523e-04 3.288 0 0
Josephin domain DUBs R-HSA-5689877 5.347865e-04 3.272 0 0
Pexophagy R-HSA-9664873 5.347865e-04 3.272 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.363534e-04 3.271 1 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.826206e-04 3.235 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.826206e-04 3.235 0 0
Degradation of CDH1 R-HSA-9766229 6.783305e-04 3.169 0 0
Translesion synthesis by POLK R-HSA-5655862 7.155337e-04 3.145 0 0
Maturation of protein E R-HSA-9694493 7.431817e-04 3.129 0 0
Maturation of protein E R-HSA-9683683 7.431817e-04 3.129 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.076535e-04 3.042 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.986814e-04 3.046 0 0
G2/M Checkpoints R-HSA-69481 9.413023e-04 3.026 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.009050e-03 2.996 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.009050e-03 2.996 0 0
NF-kB is activated and signals survival R-HSA-209560 1.009050e-03 2.996 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.016932e-03 2.993 1 0
Chaperone Mediated Autophagy R-HSA-9613829 1.137205e-03 2.944 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.137205e-03 2.944 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.243597e-03 2.905 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.338403e-03 2.873 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.338403e-03 2.873 0 0
Gap junction trafficking R-HSA-190828 1.356735e-03 2.868 0 0
Translesion Synthesis by POLH R-HSA-110320 1.408787e-03 2.851 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.414748e-03 2.849 1 0
Axon guidance R-HSA-422475 1.562351e-03 2.806 1 0
Signaling by EGFR R-HSA-177929 1.594690e-03 2.797 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.824126e-03 2.739 1 1
Post-chaperonin tubulin folding pathway R-HSA-389977 1.727199e-03 2.763 0 0
MAPK family signaling cascades R-HSA-5683057 1.836462e-03 2.736 1 0
Apoptotic execution phase R-HSA-75153 1.748759e-03 2.757 0 0
Nervous system development R-HSA-9675108 1.828175e-03 2.738 1 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.752009e-03 2.756 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.050345e-03 2.688 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.112006e-03 2.675 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.225763e-03 2.653 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.225763e-03 2.653 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.112006e-03 2.675 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.259872e-03 2.646 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.524586e-03 2.598 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.717203e-03 2.566 0 0
Vesicle-mediated transport R-HSA-5653656 2.515447e-03 2.599 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.364754e-03 2.626 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.391487e-03 2.621 0 0
Kinesins R-HSA-983189 2.459556e-03 2.609 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.524586e-03 2.598 0 0
Assembly Of The HIV Virion R-HSA-175474 2.524586e-03 2.598 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.364754e-03 2.626 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.364754e-03 2.626 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.722665e-03 2.565 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.782635e-03 2.556 0 0
EGFR downregulation R-HSA-182971 2.782635e-03 2.556 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.802103e-03 2.553 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.802103e-03 2.553 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.807445e-03 2.552 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.327558e-03 2.478 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.327558e-03 2.478 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.155680e-03 2.501 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.222255e-03 2.492 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.404617e-03 2.468 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.479277e-03 2.459 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.013954e-03 2.521 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.013954e-03 2.521 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.365849e-03 2.473 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.885839e-03 2.540 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.216619e-03 2.493 0 0
Orc1 removal from chromatin R-HSA-68949 3.491291e-03 2.457 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.491665e-03 2.457 1 1
MAP2K and MAPK activation R-HSA-5674135 3.491665e-03 2.457 1 1
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.491665e-03 2.457 0 0
Circadian clock R-HSA-9909396 3.537622e-03 2.451 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.637359e-03 2.439 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.700438e-03 2.432 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.700438e-03 2.432 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.700438e-03 2.432 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.200829e-03 2.377 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.200829e-03 2.377 0 0
Glycolysis R-HSA-70171 4.266143e-03 2.370 0 0
Regulation of TP53 Activity R-HSA-5633007 4.090982e-03 2.388 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.030313e-03 2.395 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.266604e-03 2.370 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.266604e-03 2.370 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.270299e-03 2.370 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.423104e-03 2.354 0 0
Host Interactions of HIV factors R-HSA-162909 4.428975e-03 2.354 0 0
Apoptosis R-HSA-109581 4.574892e-03 2.340 0 0
SDK interactions R-HSA-373756 4.582649e-03 2.339 0 0
Dual Incision in GG-NER R-HSA-5696400 4.831801e-03 2.316 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.831801e-03 2.316 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.845437e-03 2.315 0 0
G1/S Transition R-HSA-69206 5.030688e-03 2.298 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 5.173326e-03 2.286 0 0
Glycogen storage diseases R-HSA-3229121 5.173326e-03 2.286 0 0
Signaling by Hippo R-HSA-2028269 5.173326e-03 2.286 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.486585e-03 2.261 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.526847e-03 2.258 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.151575e-03 2.211 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.151575e-03 2.211 1 1
Signaling downstream of RAS mutants R-HSA-9649948 6.151575e-03 2.211 1 1
Signaling by RAS mutants R-HSA-6802949 6.151575e-03 2.211 1 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.860256e-03 2.164 0 0
L1CAM interactions R-HSA-373760 6.311951e-03 2.200 1 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.992710e-03 2.155 0 0
Degradation of DVL R-HSA-4641258 6.992710e-03 2.155 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.992710e-03 2.155 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.993320e-03 2.155 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.381190e-03 2.132 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.637854e-03 2.064 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.084624e-03 2.092 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.627980e-03 2.118 1 0
Switching of origins to a post-replicative state R-HSA-69052 8.084624e-03 2.092 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.451205e-03 2.073 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.356573e-03 2.078 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.133043e-03 2.090 0 0
Glycogen synthesis R-HSA-3322077 8.699889e-03 2.060 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.605948e-03 2.119 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.217561e-03 2.085 0 0
Co-stimulation by CD28 R-HSA-389356 7.564637e-03 2.121 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.560549e-03 2.121 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.637854e-03 2.064 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.851440e-03 2.105 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.731693e-03 2.059 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.731693e-03 2.059 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.560549e-03 2.121 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.731693e-03 2.059 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.731693e-03 2.059 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.841901e-03 2.053 0 0
Heme signaling R-HSA-9707616 9.131226e-03 2.039 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.209018e-03 2.036 0 0
Centrosome maturation R-HSA-380287 9.470557e-03 2.024 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.470557e-03 2.024 0 0
Post NMDA receptor activation events R-HSA-438064 9.502307e-03 2.022 0 0
Cilium Assembly R-HSA-5617833 9.530387e-03 2.021 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 9.980488e-03 2.001 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.017299e-02 1.993 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.111487e-02 1.954 0 0
UCH proteinases R-HSA-5689603 1.022815e-02 1.990 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.017299e-02 1.993 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.017299e-02 1.993 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.089449e-02 1.963 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.820885e-03 2.008 0 0
Budding and maturation of HIV virion R-HSA-162588 1.111487e-02 1.954 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.166081e-02 1.933 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.111487e-02 1.954 0 0
S Phase R-HSA-69242 9.995737e-03 2.000 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.111487e-02 1.954 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.017299e-02 1.993 0 0
Programmed Cell Death R-HSA-5357801 9.985721e-03 2.001 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.960989e-03 2.002 0 0
Interleukin-12 signaling R-HSA-9020591 1.022815e-02 1.990 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.171311e-02 1.931 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.173016e-02 1.931 1 1
Deubiquitination R-HSA-5688426 1.180608e-02 1.928 0 0
Smooth Muscle Contraction R-HSA-445355 1.215616e-02 1.915 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.295648e-02 1.888 1 1
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.367224e-02 1.864 0 0
DNA Double Strand Break Response R-HSA-5693606 1.374620e-02 1.862 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.397197e-02 1.855 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.397197e-02 1.855 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.397197e-02 1.855 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.397197e-02 1.855 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.405169e-02 1.852 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.405595e-02 1.852 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.405595e-02 1.852 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.447225e-02 1.839 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.472734e-02 1.832 0 0
Rab regulation of trafficking R-HSA-9007101 1.534351e-02 1.814 0 0
Glucose metabolism R-HSA-70326 1.534351e-02 1.814 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.548275e-02 1.810 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.548275e-02 1.810 0 0
Formation of annular gap junctions R-HSA-196025 1.793912e-02 1.746 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.559648e-02 1.807 0 0
Striated Muscle Contraction R-HSA-390522 1.571278e-02 1.804 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.571278e-02 1.804 0 0
RAF activation R-HSA-5673000 1.750000e-02 1.757 1 1
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.805412e-02 1.743 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.773746e-02 1.751 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.571278e-02 1.804 0 0
Regulation of Apoptosis R-HSA-169911 1.942197e-02 1.712 0 0
Homology Directed Repair R-HSA-5693538 1.621717e-02 1.790 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.750000e-02 1.757 0 0
Synthesis of DNA R-HSA-69239 1.733406e-02 1.761 0 0
HIV Life Cycle R-HSA-162587 1.564013e-02 1.806 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.750000e-02 1.757 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.723583e-02 1.764 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.793912e-02 1.746 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.873883e-02 1.727 0 0
Gap junction assembly R-HSA-190861 1.750000e-02 1.757 0 0
Oncogene Induced Senescence R-HSA-2559585 1.942197e-02 1.712 0 0
Regulation of BACH1 activity R-HSA-9708530 1.829879e-02 1.738 0 0
Negative regulation of FLT3 R-HSA-9706369 1.829879e-02 1.738 0 0
TCR signaling R-HSA-202403 2.053101e-02 1.688 0 0
MHC class II antigen presentation R-HSA-2132295 2.116387e-02 1.674 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.117391e-02 1.674 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.141316e-02 1.669 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.148061e-02 1.668 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.148289e-02 1.668 0 0
RET signaling R-HSA-8853659 2.148289e-02 1.668 0 0
Signaling by ERBB2 R-HSA-1227986 2.164147e-02 1.665 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.164147e-02 1.665 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.164147e-02 1.665 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.164147e-02 1.665 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.164147e-02 1.665 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.164147e-02 1.665 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.246853e-02 1.648 0 0
Gap junction degradation R-HSA-190873 2.246853e-02 1.648 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.246853e-02 1.648 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.267102e-02 1.645 0 0
Myogenesis R-HSA-525793 2.267102e-02 1.645 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.267102e-02 1.645 0 0
Signaling by NOTCH4 R-HSA-9013694 2.283996e-02 1.641 0 0
Interleukin-12 family signaling R-HSA-447115 2.331016e-02 1.632 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.368666e-02 1.625 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.368666e-02 1.625 0 0
HIV Infection R-HSA-162906 2.420368e-02 1.616 0 0
Signaling by VEGF R-HSA-194138 2.462803e-02 1.609 0 0
Hedgehog 'off' state R-HSA-5610787 2.463476e-02 1.608 0 0
DNA Damage Bypass R-HSA-73893 2.504732e-02 1.601 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.542364e-02 1.595 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.542364e-02 1.595 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.542364e-02 1.595 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.544992e-02 1.594 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.598561e-02 1.585 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.598561e-02 1.585 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.603696e-02 1.584 0 0
Signaling by NOTCH1 R-HSA-1980143 2.608331e-02 1.584 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.617797e-02 1.582 0 0
Death Receptor Signaling R-HSA-73887 2.702870e-02 1.568 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.752525e-02 1.560 0 0
2-LTR circle formation R-HSA-164843 2.756206e-02 1.560 0 0
Regulation of CDH11 function R-HSA-9762292 2.756206e-02 1.560 0 0
Developmental Cell Lineages R-HSA-9734767 2.779892e-02 1.556 0 0
Downstream TCR signaling R-HSA-202424 2.792009e-02 1.554 0 0
Regulation of gap junction activity R-HSA-191650 3.623490e-02 1.441 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.492854e-02 1.457 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.853722e-02 1.545 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.119058e-02 1.506 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.172475e-02 1.499 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.419165e-02 1.466 0 0
Translation initiation complex formation R-HSA-72649 3.678274e-02 1.434 0 0
Neutrophil degranulation R-HSA-6798695 3.757829e-02 1.425 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.697401e-02 1.432 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.119058e-02 1.506 0 0
Nephrin family interactions R-HSA-373753 3.697401e-02 1.432 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.696774e-02 1.432 0 0
PCP/CE pathway R-HSA-4086400 2.963948e-02 1.528 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.502883e-02 1.456 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.260982e-02 1.487 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.399989e-02 1.469 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 3.623490e-02 1.441 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.119058e-02 1.506 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.119058e-02 1.506 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.399989e-02 1.469 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.119058e-02 1.506 0 0
Stabilization of p53 R-HSA-69541 2.853722e-02 1.545 0 0
Glycogen metabolism R-HSA-8982491 3.119058e-02 1.506 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.895229e-02 1.538 0 0
Sensory processing of sound R-HSA-9659379 3.153894e-02 1.501 0 0
Signaling by FGFR2 R-HSA-5654738 3.352137e-02 1.475 0 0
Regulation of signaling by CBL R-HSA-912631 3.260982e-02 1.487 0 0
FLT3 Signaling R-HSA-9607240 3.399989e-02 1.469 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.780948e-02 1.422 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.852390e-02 1.414 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.852390e-02 1.414 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.942636e-02 1.404 0 0
Integration of provirus R-HSA-162592 3.942636e-02 1.404 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.942636e-02 1.404 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.942636e-02 1.404 0 0
Signaling by NOTCH3 R-HSA-9012852 3.949994e-02 1.403 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.956231e-02 1.403 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.165783e-02 1.380 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 4.165783e-02 1.380 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 4.165783e-02 1.380 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.234501e-02 1.373 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.234501e-02 1.373 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.331015e-02 1.363 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.338784e-02 1.363 0 0
Signaling by FGFR4 R-HSA-5654743 4.338784e-02 1.363 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.338784e-02 1.363 0 0
Muscle contraction R-HSA-397014 4.400777e-02 1.356 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.484896e-02 1.348 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.531952e-02 1.344 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.553410e-02 1.342 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.553410e-02 1.342 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.618001e-02 1.336 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.618001e-02 1.336 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.618001e-02 1.336 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.618001e-02 1.336 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.618001e-02 1.336 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.618001e-02 1.336 0 0
Repression of WNT target genes R-HSA-4641265 4.618001e-02 1.336 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.636966e-02 1.334 0 0
Integrin signaling R-HSA-354192 4.636966e-02 1.334 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.636966e-02 1.334 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.666153e-02 1.331 0 0
G1 Phase R-HSA-69236 4.684376e-02 1.329 0 0
Cyclin D associated events in G1 R-HSA-69231 4.684376e-02 1.329 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.717370e-02 1.326 0 0
IRS activation R-HSA-74713 4.776534e-02 1.321 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.776534e-02 1.321 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.776534e-02 1.321 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.776534e-02 1.321 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.829048e-02 1.316 0 0
Defective OGG1 Localization R-HSA-9657050 4.829048e-02 1.316 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 4.829048e-02 1.316 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.832260e-02 1.316 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.832260e-02 1.316 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.842487e-02 1.315 0 0
Dual incision in TC-NER R-HSA-6782135 4.842487e-02 1.315 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.842487e-02 1.315 0 0
DNA Replication R-HSA-69306 4.904563e-02 1.309 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.046552e-02 1.297 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.046552e-02 1.297 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.046552e-02 1.297 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.046552e-02 1.297 0 0
Signaling by FGFR3 R-HSA-5654741 5.046552e-02 1.297 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.062289e-02 1.296 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.062289e-02 1.296 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.042960e-02 1.219 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.042960e-02 1.219 0 0
Signaling by MAPK mutants R-HSA-9652817 6.042960e-02 1.219 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.409159e-02 1.130 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.346459e-02 1.272 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.126420e-02 1.213 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.956083e-02 1.158 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.956083e-02 1.158 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.833461e-02 1.106 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.833461e-02 1.106 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.821053e-02 1.235 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.233501e-02 1.205 0 0
Protein ubiquitination R-HSA-8852135 5.734437e-02 1.242 0 0
Signaling by MET R-HSA-6806834 7.461229e-02 1.127 0 0
Nucleotide Excision Repair R-HSA-5696398 6.955322e-02 1.158 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.734437e-02 1.242 0 0
Formation of axial mesoderm R-HSA-9796292 5.346459e-02 1.272 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.903907e-02 1.229 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.042960e-02 1.219 1 1
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.979288e-02 1.223 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.979288e-02 1.223 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.979288e-02 1.223 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.111664e-02 1.148 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.955322e-02 1.158 1 0
DNA Repair R-HSA-73894 6.452952e-02 1.190 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.984702e-02 1.223 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.409159e-02 1.130 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.833461e-02 1.106 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.470915e-02 1.189 0 0
Degradation of AXIN R-HSA-4641257 6.984507e-02 1.156 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.984507e-02 1.156 0 0
Intraflagellar transport R-HSA-5620924 6.233501e-02 1.205 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.571733e-02 1.121 0 0
Semaphorin interactions R-HSA-373755 6.595030e-02 1.181 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.425419e-02 1.266 0 0
Cellular response to heat stress R-HSA-3371556 7.661473e-02 1.116 0 0
Mitotic Prophase R-HSA-68875 7.363425e-02 1.133 0 0
Nef and signal transduction R-HSA-164944 7.409159e-02 1.130 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.509729e-02 1.259 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.509729e-02 1.259 0 0
RAB geranylgeranylation R-HSA-8873719 5.503278e-02 1.259 0 0
Diseases of DNA repair R-HSA-9675135 5.425419e-02 1.266 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.272678e-02 1.278 1 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.042960e-02 1.219 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.461229e-02 1.127 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.409159e-02 1.130 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.956083e-02 1.158 0 0
Nuclear import of Rev protein R-HSA-180746 5.509729e-02 1.259 0 0
MAP kinase activation R-HSA-450294 5.853722e-02 1.233 1 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.662778e-02 1.176 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.662778e-02 1.176 0 0
Diseases of Base Excision Repair R-HSA-9605308 6.042960e-02 1.219 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.841493e-02 1.165 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.509729e-02 1.259 0 0
FLT3 signaling in disease R-HSA-9682385 6.470915e-02 1.189 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.762356e-02 1.239 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.042960e-02 1.219 0 0
Signaling by ROBO receptors R-HSA-376176 5.420757e-02 1.266 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.579502e-02 1.120 0 0
Signaling by ALK in cancer R-HSA-9700206 7.579502e-02 1.120 0 0
Signaling by NOTCH2 R-HSA-1980145 5.509729e-02 1.259 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.425419e-02 1.266 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.263193e-02 1.139 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.640565e-02 1.117 0 0
PKR-mediated signaling R-HSA-9833482 7.461229e-02 1.127 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.904269e-02 1.102 1 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.051297e-02 1.094 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.076924e-02 1.093 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.076924e-02 1.093 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.076924e-02 1.093 0 0
RAS processing R-HSA-9648002 8.076924e-02 1.093 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.237512e-02 1.084 1 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.327051e-02 1.080 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.547460e-02 1.068 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.547460e-02 1.068 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.579237e-02 1.067 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.579237e-02 1.067 1 0
Regulated Necrosis R-HSA-5218859 8.684961e-02 1.061 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.684961e-02 1.061 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.862568e-02 1.052 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.862568e-02 1.052 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.045835e-02 1.044 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.060094e-02 1.043 0 0
PTEN Regulation R-HSA-6807070 9.181517e-02 1.037 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.254743e-02 1.034 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.254743e-02 1.034 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.254743e-02 1.034 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.254743e-02 1.034 0 0
Cellular responses to stimuli R-HSA-8953897 9.268029e-02 1.033 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.288134e-02 1.032 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.288134e-02 1.032 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 9.425178e-02 1.026 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.425178e-02 1.026 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 9.425178e-02 1.026 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.425178e-02 1.026 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.425178e-02 1.026 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.425178e-02 1.026 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 9.425178e-02 1.026 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.425178e-02 1.026 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 9.425178e-02 1.026 0 0
TICAM1 deficiency - HSE R-HSA-5602566 9.425178e-02 1.026 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.425178e-02 1.026 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.470131e-02 1.024 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.503746e-02 1.022 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.589046e-02 1.018 0 0
Interleukin-17 signaling R-HSA-448424 9.615013e-02 1.017 1 0
Post-translational protein phosphorylation R-HSA-8957275 9.621680e-02 1.017 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.621680e-02 1.017 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.621680e-02 1.017 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.621680e-02 1.017 1 0
Signaling by FGFR R-HSA-190236 9.621680e-02 1.017 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.655288e-02 1.015 1 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.722726e-02 1.012 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.756371e-02 1.011 0 0
Cellular responses to stress R-HSA-2262752 9.758002e-02 1.011 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.786674e-02 1.009 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.786674e-02 1.009 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.786674e-02 1.009 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.786674e-02 1.009 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.874921e-02 1.005 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.874921e-02 1.005 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.874921e-02 1.005 0 0
Translation of Structural Proteins R-HSA-9683701 9.874921e-02 1.005 0 0
Platelet degranulation R-HSA-114608 9.958377e-02 1.002 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.013414e-01 0.994 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.013414e-01 0.994 0 0
TNF signaling R-HSA-75893 1.013414e-01 0.994 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.013414e-01 0.994 0 0
NRAGE signals death through JNK R-HSA-193648 1.013414e-01 0.994 0 0
Signaling by FGFR1 R-HSA-5654736 1.013414e-01 0.994 0 0
Type I hemidesmosome assembly R-HSA-446107 1.039160e-01 0.983 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.039160e-01 0.983 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.039160e-01 0.983 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.039160e-01 0.983 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.050898e-01 0.978 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.051546e-01 0.978 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.059789e-01 0.975 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.059789e-01 0.975 0 0
Ephrin signaling R-HSA-3928664 1.073002e-01 0.969 0 0
Polo-like kinase mediated events R-HSA-156711 1.073002e-01 0.969 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.080732e-01 0.966 1 0
Chaperonin-mediated protein folding R-HSA-390466 1.080977e-01 0.966 0 0
Interleukin-1 signaling R-HSA-9020702 1.086132e-01 0.964 1 0
Hemostasis R-HSA-109582 1.087347e-01 0.964 0 0
Signaling by SCF-KIT R-HSA-1433557 1.117594e-01 0.952 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.117594e-01 0.952 0 0
TBC/RABGAPs R-HSA-8854214 1.117594e-01 0.952 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.129354e-01 0.947 0 0
Signaling by WNT R-HSA-195721 1.154967e-01 0.937 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.163261e-01 0.934 0 0
Signaling by ERBB4 R-HSA-1236394 1.163261e-01 0.934 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.177591e-01 0.929 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.379961e-01 0.860 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.379961e-01 0.860 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.379961e-01 0.860 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.379961e-01 0.860 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.379961e-01 0.860 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.379961e-01 0.860 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.796302e-01 0.746 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.796302e-01 0.746 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 1.796302e-01 0.746 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 1.796302e-01 0.746 0 0
MET interacts with TNS proteins R-HSA-8875513 2.192559e-01 0.659 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.192559e-01 0.659 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.192559e-01 0.659 0 0
Defective ABCC2 causes DJS R-HSA-5679001 2.192559e-01 0.659 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.192559e-01 0.659 0 0
MET activates PTPN11 R-HSA-8865999 2.192559e-01 0.659 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.192559e-01 0.659 0 0
ARMS-mediated activation R-HSA-170984 1.198559e-01 0.921 0 0
WNT mediated activation of DVL R-HSA-201688 1.198559e-01 0.921 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 1.198559e-01 0.921 0 0
ALK mutants bind TKIs R-HSA-9700645 1.198559e-01 0.921 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.363471e-01 0.865 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.532994e-01 0.814 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.532994e-01 0.814 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.532994e-01 0.814 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.706300e-01 0.768 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.882628e-01 0.725 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.882628e-01 0.725 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.285793e-01 0.891 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.285793e-01 0.891 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.061285e-01 0.686 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.061285e-01 0.686 0 0
FGFR2 alternative splicing R-HSA-6803529 1.629596e-01 0.788 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.479659e-01 0.830 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.123580e-01 0.673 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.327242e-01 0.877 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.327242e-01 0.877 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.247139e-01 0.904 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.158863e-01 0.666 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.326094e-01 0.633 0 0
Ub-specific processing proteases R-HSA-5689880 1.625405e-01 0.789 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 1.665030e-01 0.779 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.061285e-01 0.686 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.999254e-01 0.699 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.999254e-01 0.699 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.996997e-01 0.700 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.996997e-01 0.700 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.479659e-01 0.830 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.882628e-01 0.725 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.540610e-01 0.812 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.198559e-01 0.921 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.882628e-01 0.725 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.302911e-01 0.885 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.400788e-01 0.854 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.457744e-01 0.836 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.996997e-01 0.700 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.793399e-01 0.746 0 0
Signal attenuation R-HSA-74749 1.363471e-01 0.865 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.051480e-01 0.688 1 0
Signaling by WNT in cancer R-HSA-4791275 1.218041e-01 0.914 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.400788e-01 0.854 0 0
DNA strand elongation R-HSA-69190 1.218041e-01 0.914 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.379961e-01 0.860 0 0
MET activates STAT3 R-HSA-8875791 2.192559e-01 0.659 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.192559e-01 0.659 0 0
Unwinding of DNA R-HSA-176974 1.198559e-01 0.921 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.198559e-01 0.921 0 0
Bicarbonate transporters R-HSA-425381 1.532994e-01 0.814 0 0
Signaling by APC mutants R-HSA-4839744 1.532994e-01 0.814 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.706300e-01 0.768 0 0
Signaling by AXIN mutants R-HSA-4839735 1.706300e-01 0.768 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.512045e-01 0.820 0 0
Notch-HLH transcription pathway R-HSA-350054 1.629596e-01 0.788 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.479659e-01 0.830 0 0
Signalling to ERKs R-HSA-187687 1.571323e-01 0.804 1 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.255492e-01 0.901 0 0
snRNP Assembly R-HSA-191859 1.186405e-01 0.926 0 0
Metabolism of non-coding RNA R-HSA-194441 1.186405e-01 0.926 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.309361e-01 0.883 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.289352e-01 0.890 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.289352e-01 0.890 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.424230e-01 0.846 1 0
HATs acetylate histones R-HSA-3214847 1.830453e-01 0.737 0 0
Protein folding R-HSA-391251 1.378120e-01 0.861 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.424230e-01 0.846 1 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.872314e-01 0.728 0 0
Amyloid fiber formation R-HSA-977225 1.564198e-01 0.806 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.251832e-01 0.647 0 0
Cellular response to chemical stress R-HSA-9711123 1.299506e-01 0.886 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.141790e-01 0.669 0 0
Long-term potentiation R-HSA-9620244 1.996997e-01 0.700 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.123580e-01 0.673 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.858122e-01 0.731 0 0
Cellular response to hypoxia R-HSA-1234174 1.572466e-01 0.803 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.653791e-01 0.782 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.430451e-01 0.845 0 0
Chromatin organization R-HSA-4839726 1.861226e-01 0.730 0 0
Kidney development R-HSA-9830369 1.712036e-01 0.766 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.773178e-01 0.751 0 0
TGFBR3 expression R-HSA-9839394 1.996997e-01 0.700 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.255492e-01 0.901 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.302911e-01 0.885 0 0
RUNX2 regulates bone development R-HSA-8941326 1.665030e-01 0.779 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.125263e-01 0.673 0 0
Intracellular oxygen transport R-HSA-8981607 2.192559e-01 0.659 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.532994e-01 0.814 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.706300e-01 0.768 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.882628e-01 0.725 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.553040e-01 0.809 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.711767e-01 0.767 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.930508e-01 0.714 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.397361e-01 0.855 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.765717e-01 0.753 1 0
Signal regulatory protein family interactions R-HSA-391160 2.241635e-01 0.649 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.749767e-01 0.757 0 0
Base Excision Repair R-HSA-73884 2.228435e-01 0.652 0 0
RSV-host interactions R-HSA-9833110 2.206376e-01 0.656 0 0
Chromatin modifying enzymes R-HSA-3247509 1.982074e-01 0.703 0 0
Developmental Biology R-HSA-1266738 1.624567e-01 0.789 1 0
Receptor Mediated Mitophagy R-HSA-8934903 1.363471e-01 0.865 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.241635e-01 0.649 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.185592e-01 0.926 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.571323e-01 0.804 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.373039e-01 0.862 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.116611e-01 0.674 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.438140e-01 0.842 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.711780e-01 0.767 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.218041e-01 0.914 0 0
Activation of RAC1 R-HSA-428540 1.706300e-01 0.768 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.061285e-01 0.686 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.061285e-01 0.686 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.749767e-01 0.757 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.957275e-01 0.708 0 0
Signaling by Hedgehog R-HSA-5358351 1.518796e-01 0.819 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.014861e-01 0.696 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.255492e-01 0.901 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.176303e-01 0.662 0 0
Signaling by NTRKs R-HSA-166520 2.051480e-01 0.688 1 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.262204e-01 0.899 0 0
Formation of the nephric duct R-HSA-9830364 1.996997e-01 0.700 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.198559e-01 0.921 0 0
Formation of intermediate mesoderm R-HSA-9761174 1.363471e-01 0.865 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.706300e-01 0.768 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.241635e-01 0.649 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.327242e-01 0.877 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.930508e-01 0.714 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.744867e-01 0.758 0 0
Interferon Signaling R-HSA-913531 2.096433e-01 0.679 0 0
Hedgehog 'on' state R-HSA-5632684 2.005589e-01 0.698 0 0
ABC-family proteins mediated transport R-HSA-382556 1.891092e-01 0.723 0 0
Interleukin-1 family signaling R-HSA-446652 2.262959e-01 0.645 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.311067e-01 0.882 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.160211e-01 0.666 0 0
Ion channel transport R-HSA-983712 2.360545e-01 0.627 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.793399e-01 0.746 0 0
Pyruvate metabolism R-HSA-70268 2.019283e-01 0.695 0 0
Stimuli-sensing channels R-HSA-2672351 1.457744e-01 0.836 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.532994e-01 0.814 0 0
G0 and Early G1 R-HSA-1538133 1.218041e-01 0.914 0 0
Neurodegenerative Diseases R-HSA-8863678 1.872314e-01 0.728 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.872314e-01 0.728 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.711767e-01 0.767 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.274851e-01 0.895 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.251832e-01 0.647 0 0
Iron uptake and transport R-HSA-917937 2.315974e-01 0.635 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.185592e-01 0.926 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.397361e-01 0.855 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.061285e-01 0.686 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.951320e-01 0.710 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 1.828572e-01 0.738 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.368347e-01 0.626 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.368543e-01 0.626 0 0
IRE1alpha activates chaperones R-HSA-381070 2.371915e-01 0.625 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.381529e-01 0.623 0 0
Peroxisomal protein import R-HSA-9033241 2.400858e-01 0.620 0 0
DCC mediated attractive signaling R-HSA-418885 2.423099e-01 0.616 0 0
p38MAPK events R-HSA-171007 2.423099e-01 0.616 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.423099e-01 0.616 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.423099e-01 0.616 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.423099e-01 0.616 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.423099e-01 0.616 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.426989e-01 0.615 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 2.444764e-01 0.612 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.471596e-01 0.607 0 0
Translation of Structural Proteins R-HSA-9694635 2.476538e-01 0.606 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.486785e-01 0.604 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.491944e-01 0.603 0 0
Platelet calcium homeostasis R-HSA-418360 2.512454e-01 0.600 0 0
G alpha (12/13) signalling events R-HSA-416482 2.557992e-01 0.592 0 0
ABC transporter disorders R-HSA-5619084 2.557992e-01 0.592 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.569698e-01 0.590 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.569698e-01 0.590 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.569698e-01 0.590 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.569698e-01 0.590 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.569698e-01 0.590 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.569698e-01 0.590 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.569698e-01 0.590 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.569698e-01 0.590 0 0
GABA synthesis R-HSA-888568 2.569698e-01 0.590 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.580336e-01 0.588 0 0
Netrin-1 signaling R-HSA-373752 2.581344e-01 0.588 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.583893e-01 0.588 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.605150e-01 0.584 0 0
Killing mechanisms R-HSA-9664420 2.605150e-01 0.584 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.605150e-01 0.584 0 0
Prolonged ERK activation events R-HSA-169893 2.605150e-01 0.584 1 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.605150e-01 0.584 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.605150e-01 0.584 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.613929e-01 0.583 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.644395e-01 0.578 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.667318e-01 0.574 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.676635e-01 0.572 0 0
tRNA processing in the nucleus R-HSA-6784531 2.676635e-01 0.572 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.689136e-01 0.570 0 0
Innate Immune System R-HSA-168249 2.709562e-01 0.567 1 0
HCMV Early Events R-HSA-9609690 2.717889e-01 0.566 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.723001e-01 0.565 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.770098e-01 0.558 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.770098e-01 0.558 0 0
Signaling by PTK6 R-HSA-8848021 2.770098e-01 0.558 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.787308e-01 0.555 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.787308e-01 0.555 0 0
Disorders of Developmental Biology R-HSA-9675151 2.787308e-01 0.555 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.787308e-01 0.555 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.787308e-01 0.555 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.787308e-01 0.555 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.797707e-01 0.553 0 0
Signaling by TGFBR3 R-HSA-9839373 2.797707e-01 0.553 0 0
Influenza Infection R-HSA-168255 2.798659e-01 0.553 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.806456e-01 0.552 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.890480e-01 0.539 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.906947e-01 0.537 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.928642e-01 0.533 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.928642e-01 0.533 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.928642e-01 0.533 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.928642e-01 0.533 0 0
Activation of AKT2 R-HSA-165158 2.928642e-01 0.533 0 0
Suppression of autophagy R-HSA-9636569 2.928642e-01 0.533 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.928642e-01 0.533 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.928642e-01 0.533 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.928642e-01 0.533 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.928642e-01 0.533 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.937096e-01 0.532 0 0
Gluconeogenesis R-HSA-70263 3.016749e-01 0.520 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.037516e-01 0.517 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.044322e-01 0.517 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.044322e-01 0.517 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.044322e-01 0.517 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.054112e-01 0.515 0 0
Signaling by NOTCH R-HSA-157118 3.105697e-01 0.508 0 0
Meiosis R-HSA-1500620 3.145470e-01 0.502 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.150251e-01 0.502 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.150251e-01 0.502 0 0
GAB1 signalosome R-HSA-180292 3.150251e-01 0.502 0 0
Platelet sensitization by LDL R-HSA-432142 3.150251e-01 0.502 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.178372e-01 0.498 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.178372e-01 0.498 0 0
mRNA Splicing R-HSA-72172 3.201099e-01 0.495 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.270266e-01 0.485 0 0
TRAIL signaling R-HSA-75158 3.270266e-01 0.485 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.270266e-01 0.485 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.270266e-01 0.485 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.270266e-01 0.485 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.270266e-01 0.485 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.270266e-01 0.485 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.270266e-01 0.485 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.270266e-01 0.485 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.270266e-01 0.485 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.270266e-01 0.485 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.270266e-01 0.485 0 0
PI Metabolism R-HSA-1483255 3.283754e-01 0.484 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.312499e-01 0.480 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.312499e-01 0.480 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.312499e-01 0.480 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.317410e-01 0.479 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.330288e-01 0.478 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.330288e-01 0.478 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.330288e-01 0.478 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 3.330288e-01 0.478 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 3.330288e-01 0.478 0 0
Rap1 signalling R-HSA-392517 3.330288e-01 0.478 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.354784e-01 0.474 0 0
COPII-mediated vesicle transport R-HSA-204005 3.438699e-01 0.464 0 0
Neurexins and neuroligins R-HSA-6794361 3.459520e-01 0.461 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.477377e-01 0.459 0 0
Toll-like Receptor Cascades R-HSA-168898 3.482984e-01 0.458 1 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.508933e-01 0.455 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.508933e-01 0.455 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.508933e-01 0.455 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.508933e-01 0.455 0 0
Creatine metabolism R-HSA-71288 3.508933e-01 0.455 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.508933e-01 0.455 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.508933e-01 0.455 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.546045e-01 0.450 0 0
Meiotic synapsis R-HSA-1221632 3.570611e-01 0.447 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.570611e-01 0.447 0 0
ER-Phagosome pathway R-HSA-1236974 3.577288e-01 0.446 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.595406e-01 0.444 0 0
Signaling by LTK in cancer R-HSA-9842640 3.595406e-01 0.444 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.595406e-01 0.444 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.595406e-01 0.444 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 3.595406e-01 0.444 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.595406e-01 0.444 0 0
MET Receptor Activation R-HSA-6806942 3.595406e-01 0.444 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.595406e-01 0.444 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.595406e-01 0.444 0 0
CREB phosphorylation R-HSA-199920 3.595406e-01 0.444 0 0
Neurofascin interactions R-HSA-447043 3.595406e-01 0.444 0 0
HCMV Infection R-HSA-9609646 3.618499e-01 0.441 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.632332e-01 0.440 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.632332e-01 0.440 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.660770e-01 0.436 1 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.681674e-01 0.434 0 0
Lagging Strand Synthesis R-HSA-69186 3.685901e-01 0.433 0 0
Signalling to RAS R-HSA-167044 3.685901e-01 0.433 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.685901e-01 0.433 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.718062e-01 0.430 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 3.729263e-01 0.428 0 0
Parasite infection R-HSA-9664407 3.753008e-01 0.426 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.753008e-01 0.426 0 0
Leishmania phagocytosis R-HSA-9664417 3.753008e-01 0.426 0 0
Signaling by Interleukins R-HSA-449147 3.816681e-01 0.418 1 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.838420e-01 0.416 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.846619e-01 0.415 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.846619e-01 0.415 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.860936e-01 0.413 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.860936e-01 0.413 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.860936e-01 0.413 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.860936e-01 0.413 0 0
Signaling by TGFB family members R-HSA-9006936 3.874227e-01 0.412 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.904855e-01 0.408 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.904855e-01 0.408 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.904855e-01 0.408 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.904855e-01 0.408 0 0
SOS-mediated signalling R-HSA-112412 3.904855e-01 0.408 0 0
Recycling of eIF2:GDP R-HSA-72731 3.904855e-01 0.408 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.904855e-01 0.408 0 0
Netrin mediated repulsion signals R-HSA-418886 3.904855e-01 0.408 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.904855e-01 0.408 0 0
EPH-Ephrin signaling R-HSA-2682334 3.925535e-01 0.406 0 0
Pentose phosphate pathway R-HSA-71336 3.978833e-01 0.400 0 0
mTORC1-mediated signalling R-HSA-166208 4.033814e-01 0.394 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.033814e-01 0.394 1 0
Generation of second messenger molecules R-HSA-202433 4.110261e-01 0.386 0 0
Inositol phosphate metabolism R-HSA-1483249 4.158144e-01 0.381 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.199371e-01 0.377 0 0
MET receptor recycling R-HSA-8875656 4.199371e-01 0.377 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.199371e-01 0.377 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.199371e-01 0.377 0 0
Regulation by c-FLIP R-HSA-3371378 4.199371e-01 0.377 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.199371e-01 0.377 0 0
Dimerization of procaspase-8 R-HSA-69416 4.199371e-01 0.377 0 0
RSK activation R-HSA-444257 4.199371e-01 0.377 0 0
Adrenoceptors R-HSA-390696 4.199371e-01 0.377 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.199371e-01 0.377 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.204333e-01 0.376 0 0
Syndecan interactions R-HSA-3000170 4.204333e-01 0.376 0 0
Formation of the ureteric bud R-HSA-9830674 4.204333e-01 0.376 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.212696e-01 0.375 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.233589e-01 0.373 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.240785e-01 0.373 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.273223e-01 0.369 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.273223e-01 0.369 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.308750e-01 0.366 0 0
Deadenylation of mRNA R-HSA-429947 4.372320e-01 0.359 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.372320e-01 0.359 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.479673e-01 0.349 0 0
Lipophagy R-HSA-9613354 4.479673e-01 0.349 0 0
CASP8 activity is inhibited R-HSA-5218900 4.479673e-01 0.349 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.479673e-01 0.349 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.479673e-01 0.349 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.479673e-01 0.349 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.479673e-01 0.349 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.479673e-01 0.349 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.479673e-01 0.349 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.479673e-01 0.349 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.479673e-01 0.349 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.498695e-01 0.347 0 0
Depyrimidination R-HSA-73928 4.498695e-01 0.347 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.507594e-01 0.346 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.537620e-01 0.343 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.537620e-01 0.343 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.689156e-01 0.329 0 0
MET activates PTK2 signaling R-HSA-8874081 4.700101e-01 0.328 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.700101e-01 0.328 0 0
Sphingolipid catabolism R-HSA-9845614 4.700101e-01 0.328 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.700101e-01 0.328 0 0
Mitochondrial biogenesis R-HSA-1592230 4.712189e-01 0.327 0 0
Extracellular matrix organization R-HSA-1474244 4.721726e-01 0.326 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.724517e-01 0.326 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.746446e-01 0.324 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.746446e-01 0.324 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.746446e-01 0.324 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.746446e-01 0.324 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.746446e-01 0.324 0 0
Formation of apoptosome R-HSA-111458 4.746446e-01 0.324 0 0
PI3K/AKT activation R-HSA-198203 4.746446e-01 0.324 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.746446e-01 0.324 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.746446e-01 0.324 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.746446e-01 0.324 0 0
Arachidonate production from DAG R-HSA-426048 4.746446e-01 0.324 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.746446e-01 0.324 0 0
Maturation of spike protein R-HSA-9683686 4.746446e-01 0.324 0 0
Sperm Motility And Taxes R-HSA-1300642 4.746446e-01 0.324 0 0
Signaling by Leptin R-HSA-2586552 4.746446e-01 0.324 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.751778e-01 0.323 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.790529e-01 0.320 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.859650e-01 0.313 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.859650e-01 0.313 0 0
Nucleosome assembly R-HSA-774815 4.876294e-01 0.312 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.876294e-01 0.312 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.876428e-01 0.312 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.969184e-01 0.304 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.000343e-01 0.301 0 0
Interleukin-2 signaling R-HSA-9020558 5.000343e-01 0.301 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.000343e-01 0.301 0 0
PECAM1 interactions R-HSA-210990 5.000343e-01 0.301 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.000343e-01 0.301 0 0
Ribosome-associated quality control R-HSA-9948299 5.008024e-01 0.300 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.040545e-01 0.298 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.169584e-01 0.287 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.176342e-01 0.286 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.189857e-01 0.285 0 0
Co-inhibition by PD-1 R-HSA-389948 5.214721e-01 0.283 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.222252e-01 0.282 0 0
Cellular Senescence R-HSA-2559583 5.237481e-01 0.281 0 0
NGF-stimulated transcription R-HSA-9031628 5.240859e-01 0.281 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.241984e-01 0.281 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.241984e-01 0.281 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.241984e-01 0.281 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.241984e-01 0.281 0 0
ERKs are inactivated R-HSA-202670 5.241984e-01 0.281 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.241984e-01 0.281 0 0
Peptide chain elongation R-HSA-156902 5.243467e-01 0.280 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.319824e-01 0.274 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.319824e-01 0.274 0 0
Interleukin-37 signaling R-HSA-9008059 5.319824e-01 0.274 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.450864e-01 0.264 0 0
Cargo concentration in the ER R-HSA-5694530 5.466839e-01 0.262 0 0
Downstream signal transduction R-HSA-186763 5.466839e-01 0.262 0 0
MET activates RAS signaling R-HSA-8851805 5.471960e-01 0.262 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.471960e-01 0.262 0 0
Interleukin-15 signaling R-HSA-8983432 5.471960e-01 0.262 0 0
Leading Strand Synthesis R-HSA-69109 5.471960e-01 0.262 0 0
Polymerase switching R-HSA-69091 5.471960e-01 0.262 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.471960e-01 0.262 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.471960e-01 0.262 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.471960e-01 0.262 0 0
Pervasive developmental disorders R-HSA-9005895 5.471960e-01 0.262 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.471960e-01 0.262 0 0
Disorders of Nervous System Development R-HSA-9697154 5.471960e-01 0.262 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.471960e-01 0.262 0 0
OAS antiviral response R-HSA-8983711 5.471960e-01 0.262 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.492024e-01 0.260 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.492024e-01 0.260 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.511057e-01 0.259 0 0
HSF1-dependent transactivation R-HSA-3371571 5.590702e-01 0.253 0 0
Meiotic recombination R-HSA-912446 5.590702e-01 0.253 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.610590e-01 0.251 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.610590e-01 0.251 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.610590e-01 0.251 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.685326e-01 0.245 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.685326e-01 0.245 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.690833e-01 0.245 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.690833e-01 0.245 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.690833e-01 0.245 0 0
Frs2-mediated activation R-HSA-170968 5.690833e-01 0.245 1 1
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.690833e-01 0.245 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.690833e-01 0.245 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.690833e-01 0.245 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.690833e-01 0.245 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.690833e-01 0.245 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.690833e-01 0.245 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.751049e-01 0.240 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.751049e-01 0.240 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.815120e-01 0.235 0 0
Reproduction R-HSA-1474165 5.842111e-01 0.233 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.878822e-01 0.231 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.888199e-01 0.230 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.888199e-01 0.230 0 0
Glutamate and glutamine metabolism R-HSA-8964539 5.888199e-01 0.230 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.899139e-01 0.229 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.899139e-01 0.229 0 0
Removal of the Flap Intermediate R-HSA-69166 5.899139e-01 0.229 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.899139e-01 0.229 0 0
Regulation of KIT signaling R-HSA-1433559 5.899139e-01 0.229 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.899139e-01 0.229 0 0
Physiological factors R-HSA-5578768 5.899139e-01 0.229 0 0
Zinc transporters R-HSA-435354 5.899139e-01 0.229 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.899139e-01 0.229 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.924579e-01 0.227 0 0
Immune System R-HSA-168256 5.973227e-01 0.224 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.975203e-01 0.224 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.022031e-01 0.220 0 0
Signal amplification R-HSA-392518 6.022031e-01 0.220 0 0
Eukaryotic Translation Termination R-HSA-72764 6.023045e-01 0.220 0 0
Erythropoietin activates RAS R-HSA-9027284 6.097388e-01 0.215 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.097388e-01 0.215 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.097388e-01 0.215 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.097388e-01 0.215 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.097388e-01 0.215 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.097388e-01 0.215 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.097388e-01 0.215 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.097388e-01 0.215 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.105095e-01 0.214 0 0
Ion homeostasis R-HSA-5578775 6.137862e-01 0.212 0 0
Interferon alpha/beta signaling R-HSA-909733 6.148106e-01 0.211 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.152545e-01 0.211 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.157376e-01 0.211 0 0
ESR-mediated signaling R-HSA-8939211 6.192809e-01 0.208 0 0
RNA Polymerase III Transcription R-HSA-74158 6.279750e-01 0.202 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.279750e-01 0.202 0 0
HSF1 activation R-HSA-3371511 6.279750e-01 0.202 0 0
G1/S-Specific Transcription R-HSA-69205 6.279750e-01 0.202 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.283428e-01 0.202 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.286064e-01 0.202 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 6.286064e-01 0.202 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.286064e-01 0.202 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.286064e-01 0.202 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.286064e-01 0.202 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.286064e-01 0.202 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.286064e-01 0.202 0 0
Differentiation of T cells R-HSA-9945266 6.286064e-01 0.202 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.286064e-01 0.202 0 0
Atorvastatin ADME R-HSA-9754706 6.286064e-01 0.202 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.403659e-01 0.194 0 0
Cellular response to starvation R-HSA-9711097 6.423505e-01 0.192 0 0
Extension of Telomeres R-HSA-180786 6.443422e-01 0.191 0 0
Regulation of beta-cell development R-HSA-186712 6.443422e-01 0.191 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.465629e-01 0.189 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.465629e-01 0.189 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.465629e-01 0.189 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.465629e-01 0.189 0 0
Fibronectin matrix formation R-HSA-1566977 6.465629e-01 0.189 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.465629e-01 0.189 0 0
Selenocysteine synthesis R-HSA-2408557 6.500208e-01 0.187 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.506588e-01 0.187 0 0
MET promotes cell motility R-HSA-8875878 6.524295e-01 0.185 0 0
Depurination R-HSA-73927 6.524295e-01 0.185 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.541396e-01 0.184 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 6.566879e-01 0.183 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.576110e-01 0.182 0 0
Chromosome Maintenance R-HSA-73886 6.577920e-01 0.182 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 6.577920e-01 0.182 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.636523e-01 0.178 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.636523e-01 0.178 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.636523e-01 0.178 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.636523e-01 0.178 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.636523e-01 0.178 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.636523e-01 0.178 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.636523e-01 0.178 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.636523e-01 0.178 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.636523e-01 0.178 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.636523e-01 0.178 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.636523e-01 0.178 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.637420e-01 0.178 0 0
Signaling by ALK R-HSA-201556 6.641685e-01 0.178 0 0
Viral mRNA Translation R-HSA-192823 6.650947e-01 0.177 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.714388e-01 0.173 0 0
Signaling by PDGF R-HSA-186797 6.731493e-01 0.172 0 0
Attenuation phase R-HSA-3371568 6.755859e-01 0.170 0 0
Diseases of Immune System R-HSA-5260271 6.755859e-01 0.170 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.755859e-01 0.170 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.755859e-01 0.170 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.799164e-01 0.168 0 0
Nephron development R-HSA-9831926 6.799164e-01 0.168 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.799164e-01 0.168 0 0
Apoptotic factor-mediated response R-HSA-111471 6.799164e-01 0.168 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.799164e-01 0.168 0 0
Mismatch Repair R-HSA-5358508 6.799164e-01 0.168 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.799164e-01 0.168 0 0
Tie2 Signaling R-HSA-210993 6.799164e-01 0.168 0 0
Maturation of spike protein R-HSA-9694548 6.866855e-01 0.163 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.900613e-01 0.161 0 0
Insulin receptor signalling cascade R-HSA-74751 6.913791e-01 0.160 0 0
Ion transport by P-type ATPases R-HSA-936837 6.913791e-01 0.160 0 0
Platelet homeostasis R-HSA-418346 6.939497e-01 0.159 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.953950e-01 0.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.953950e-01 0.158 0 0
Pyrimidine biosynthesis R-HSA-500753 6.953950e-01 0.158 0 0
Specification of the neural plate border R-HSA-9834899 6.953950e-01 0.158 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.953950e-01 0.158 0 0
The NLRP3 inflammasome R-HSA-844456 6.953950e-01 0.158 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.953950e-01 0.158 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.953950e-01 0.158 0 0
SLC transporter disorders R-HSA-5619102 6.955040e-01 0.158 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.974712e-01 0.156 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.974712e-01 0.156 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.008909e-01 0.154 0 0
Gene Silencing by RNA R-HSA-211000 7.008909e-01 0.154 0 0
MTOR signalling R-HSA-165159 7.079475e-01 0.150 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.101259e-01 0.149 0 0
Signaling by NODAL R-HSA-1181150 7.101259e-01 0.149 0 0
Formation of definitive endoderm R-HSA-9823730 7.101259e-01 0.149 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.101259e-01 0.149 0 0
Signal transduction by L1 R-HSA-445144 7.101259e-01 0.149 1 1
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.164665e-01 0.145 0 0
Gastrulation R-HSA-9758941 7.193104e-01 0.143 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.241453e-01 0.140 0 0
ERK/MAPK targets R-HSA-198753 7.241453e-01 0.140 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.241453e-01 0.140 0 0
Adaptive Immune System R-HSA-1280218 7.260221e-01 0.139 0 0
Leishmania infection R-HSA-9658195 7.261359e-01 0.139 0 0
Parasitic Infection Pathways R-HSA-9824443 7.261359e-01 0.139 0 0
Proteasome assembly R-HSA-9907900 7.279908e-01 0.138 0 0
RMTs methylate histone arginines R-HSA-3214858 7.279908e-01 0.138 0 0
DAP12 interactions R-HSA-2172127 7.279908e-01 0.138 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.303249e-01 0.136 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.374875e-01 0.132 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.374875e-01 0.132 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.374875e-01 0.132 0 0
Glutathione synthesis and recycling R-HSA-174403 7.374875e-01 0.132 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.374875e-01 0.132 0 0
Somitogenesis R-HSA-9824272 7.375680e-01 0.132 0 0
Protein localization R-HSA-9609507 7.413227e-01 0.130 0 0
Signaling by Insulin receptor R-HSA-74752 7.425949e-01 0.129 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.468560e-01 0.127 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.468560e-01 0.127 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.501851e-01 0.125 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.501851e-01 0.125 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.501851e-01 0.125 0 0
Signaling by KIT in disease R-HSA-9669938 7.501851e-01 0.125 0 0
LDL clearance R-HSA-8964038 7.501851e-01 0.125 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.501851e-01 0.125 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.559729e-01 0.121 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.584221e-01 0.120 0 0
HCMV Late Events R-HSA-9610379 7.620953e-01 0.118 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.622693e-01 0.118 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.622693e-01 0.118 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.622693e-01 0.118 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.622693e-01 0.118 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.622693e-01 0.118 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.622693e-01 0.118 0 0
Organic anion transport by SLCO transporters R-HSA-879518 7.622693e-01 0.118 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.622693e-01 0.118 0 0
Growth hormone receptor signaling R-HSA-982772 7.622693e-01 0.118 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.645866e-01 0.117 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.662839e-01 0.116 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.670953e-01 0.115 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.687628e-01 0.114 0 0
Signaling by FGFR in disease R-HSA-1226099 7.710907e-01 0.113 0 0
Interferon gamma signaling R-HSA-877300 7.720183e-01 0.112 0 0
Generic Transcription Pathway R-HSA-212436 7.737669e-01 0.111 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.737696e-01 0.111 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.737696e-01 0.111 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.737696e-01 0.111 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.737696e-01 0.111 0 0
SARS-CoV Infections R-HSA-9679506 7.741069e-01 0.111 0 0
Metabolism of RNA R-HSA-8953854 7.760379e-01 0.110 0 0
Telomere Maintenance R-HSA-157579 7.811086e-01 0.107 0 0
PI3K Cascade R-HSA-109704 7.812288e-01 0.107 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.847143e-01 0.105 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.847143e-01 0.105 0 0
HDMs demethylate histones R-HSA-3214842 7.847143e-01 0.105 0 0
Fertilization R-HSA-1187000 7.847143e-01 0.105 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.847143e-01 0.105 0 0
Laminin interactions R-HSA-3000157 7.847143e-01 0.105 0 0
Interleukin-7 signaling R-HSA-1266695 7.847143e-01 0.105 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.914526e-01 0.102 0 0
FOXO-mediated transcription R-HSA-9614085 7.928845e-01 0.101 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.951301e-01 0.100 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.951301e-01 0.100 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.951301e-01 0.100 0 0
TRP channels R-HSA-3295583 7.951301e-01 0.100 0 0
Urea cycle R-HSA-70635 7.951301e-01 0.100 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.951301e-01 0.100 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.951301e-01 0.100 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 7.951301e-01 0.100 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.968299e-01 0.099 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.968299e-01 0.099 0 0
RNA Polymerase II Transcription R-HSA-73857 8.005338e-01 0.097 0 0
Gene expression (Transcription) R-HSA-74160 8.042422e-01 0.095 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.042550e-01 0.095 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.042550e-01 0.095 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.050426e-01 0.094 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.050426e-01 0.094 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.050426e-01 0.094 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.050426e-01 0.094 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.050426e-01 0.094 0 0
Cristae formation R-HSA-8949613 8.050426e-01 0.094 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.050426e-01 0.094 0 0
Triglyceride biosynthesis R-HSA-75109 8.050426e-01 0.094 0 0
Insulin processing R-HSA-264876 8.050426e-01 0.094 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.050426e-01 0.094 0 0
Post-translational protein modification R-HSA-597592 8.114670e-01 0.091 0 0
Formation of the cornified envelope R-HSA-6809371 8.121352e-01 0.090 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.144760e-01 0.089 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.144760e-01 0.089 0 0
HIV elongation arrest and recovery R-HSA-167287 8.144760e-01 0.089 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.144760e-01 0.089 0 0
Insulin receptor recycling R-HSA-77387 8.144760e-01 0.089 0 0
Inflammasomes R-HSA-622312 8.144760e-01 0.089 0 0
Iron assimilation using enterobactin R-HSA-9638334 8.144760e-01 0.089 0 0
Telomere Extension By Telomerase R-HSA-171319 8.144760e-01 0.089 0 0
Paracetamol ADME R-HSA-9753281 8.183848e-01 0.087 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.216468e-01 0.085 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.216468e-01 0.085 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.216468e-01 0.085 0 0
Signaling by Erythropoietin R-HSA-9006335 8.234535e-01 0.084 0 0
mRNA Capping R-HSA-72086 8.234535e-01 0.084 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.234535e-01 0.084 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.234535e-01 0.084 0 0
DARPP-32 events R-HSA-180024 8.234535e-01 0.084 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.251015e-01 0.083 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.252117e-01 0.083 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.276605e-01 0.082 0 0
IRS-mediated signalling R-HSA-112399 8.315940e-01 0.080 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.319972e-01 0.080 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.319972e-01 0.080 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.319972e-01 0.080 0 0
DAP12 signaling R-HSA-2424491 8.319972e-01 0.080 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.319972e-01 0.080 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.319972e-01 0.080 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.319972e-01 0.080 0 0
Activation of BH3-only proteins R-HSA-114452 8.319972e-01 0.080 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.401278e-01 0.076 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.401278e-01 0.076 0 0
Neddylation R-HSA-8951664 8.421829e-01 0.075 0 0
Triglyceride metabolism R-HSA-8979227 8.439304e-01 0.074 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.439304e-01 0.074 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.478655e-01 0.072 0 0
Adipogenesis R-HSA-9843745 8.519109e-01 0.070 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.552291e-01 0.068 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.552291e-01 0.068 0 0
Nuclear RNA decay R-HSA-9930044 8.552291e-01 0.068 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.552291e-01 0.068 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.552291e-01 0.068 0 0
Cardiogenesis R-HSA-9733709 8.552291e-01 0.068 0 0
G-protein beta:gamma signalling R-HSA-397795 8.552291e-01 0.068 0 0
Recycling of bile acids and salts R-HSA-159418 8.552291e-01 0.068 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.554409e-01 0.068 0 0
Diseases of programmed cell death R-HSA-9645723 8.583474e-01 0.066 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.609009e-01 0.065 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.622367e-01 0.064 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.622367e-01 0.064 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.622367e-01 0.064 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.622367e-01 0.064 0 0
Heme degradation R-HSA-189483 8.622367e-01 0.064 0 0
Transmission across Chemical Synapses R-HSA-112315 8.664901e-01 0.062 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.689055e-01 0.061 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.689055e-01 0.061 0 0
IGF1R signaling cascade R-HSA-2428924 8.712582e-01 0.060 0 0
PERK regulates gene expression R-HSA-381042 8.752519e-01 0.058 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.752519e-01 0.058 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.761665e-01 0.057 0 0
Calmodulin induced events R-HSA-111933 8.812914e-01 0.055 0 0
CaM pathway R-HSA-111997 8.812914e-01 0.055 0 0
GPVI-mediated activation cascade R-HSA-114604 8.812914e-01 0.055 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.812914e-01 0.055 0 0
Triglyceride catabolism R-HSA-163560 8.812914e-01 0.055 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.812914e-01 0.055 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.861412e-01 0.052 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.870389e-01 0.052 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.870389e-01 0.052 0 0
Cleavage of the damaged purine R-HSA-110331 8.870389e-01 0.052 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.870389e-01 0.052 0 0
Metabolism of folate and pterines R-HSA-196757 8.870389e-01 0.052 0 0
Mitochondrial protein degradation R-HSA-9837999 8.880073e-01 0.052 0 0
Elastic fibre formation R-HSA-1566948 8.925084e-01 0.049 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.977134e-01 0.047 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.977134e-01 0.047 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.977134e-01 0.047 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.021621e-01 0.045 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.026635e-01 0.044 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.026667e-01 0.044 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.026667e-01 0.044 0 0
HIV Transcription Elongation R-HSA-167169 9.026667e-01 0.044 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.026667e-01 0.044 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.026667e-01 0.044 0 0
Interleukin-2 family signaling R-HSA-451927 9.026667e-01 0.044 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.026667e-01 0.044 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.026667e-01 0.044 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.026667e-01 0.044 0 0
Viral Infection Pathways R-HSA-9824446 9.027412e-01 0.044 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.073804e-01 0.042 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.073804e-01 0.042 0 0
Ca2+ pathway R-HSA-4086398 9.096303e-01 0.041 0 0
Aspirin ADME R-HSA-9749641 9.096303e-01 0.041 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.118661e-01 0.040 0 0
HIV Transcription Initiation R-HSA-167161 9.118661e-01 0.040 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.118661e-01 0.040 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.118661e-01 0.040 0 0
Intra-Golgi traffic R-HSA-6811438 9.118661e-01 0.040 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.131610e-01 0.039 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.131610e-01 0.039 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.150058e-01 0.039 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.161348e-01 0.038 0 0
Ca-dependent events R-HSA-111996 9.161348e-01 0.038 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.161348e-01 0.038 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.165620e-01 0.038 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.198376e-01 0.036 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.201970e-01 0.036 0 0
Neuronal System R-HSA-112316 9.221379e-01 0.035 0 0
Methylation R-HSA-156581 9.240626e-01 0.034 0 0
Amine ligand-binding receptors R-HSA-375280 9.240626e-01 0.034 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.240626e-01 0.034 0 0
Surfactant metabolism R-HSA-5683826 9.240626e-01 0.034 0 0
RNA Polymerase I Transcription R-HSA-73864 9.260290e-01 0.033 0 0
Integrin cell surface interactions R-HSA-216083 9.260290e-01 0.033 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.261547e-01 0.033 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.261547e-01 0.033 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.277413e-01 0.033 0 0
DAG and IP3 signaling R-HSA-1489509 9.277413e-01 0.033 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.289528e-01 0.032 0 0
PPARA activates gene expression R-HSA-1989781 9.294042e-01 0.032 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.312419e-01 0.031 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.312419e-01 0.031 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.317672e-01 0.031 0 0
Cardiac conduction R-HSA-5576891 9.323851e-01 0.030 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.335108e-01 0.030 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.361397e-01 0.029 0 0
GPER1 signaling R-HSA-9634597 9.377432e-01 0.028 0 0
Metal ion SLC transporters R-HSA-425410 9.377432e-01 0.028 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.390234e-01 0.027 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.403817e-01 0.027 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.436305e-01 0.025 0 0
Integration of energy metabolism R-HSA-163685 9.444244e-01 0.025 0 0
Selenoamino acid metabolism R-HSA-2408522 9.462523e-01 0.024 0 0
Complex IV assembly R-HSA-9864848 9.463622e-01 0.024 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.463622e-01 0.024 0 0
mRNA 3'-end processing R-HSA-72187 9.489617e-01 0.023 0 0
Nucleotide biosynthesis R-HSA-8956320 9.514354e-01 0.022 0 0
HDACs deacetylate histones R-HSA-3214815 9.560292e-01 0.020 0 0
G alpha (z) signalling events R-HSA-418597 9.560292e-01 0.020 0 0
Neurotransmitter release cycle R-HSA-112310 9.564985e-01 0.019 0 0
tRNA processing R-HSA-72306 9.567446e-01 0.019 0 0
Peptide hormone metabolism R-HSA-2980736 9.570287e-01 0.019 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.582621e-01 0.019 0 0
Dectin-2 family R-HSA-5621480 9.601890e-01 0.018 0 0
Synthesis of PA R-HSA-1483166 9.601890e-01 0.018 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.601890e-01 0.018 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.621191e-01 0.017 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.621191e-01 0.017 0 0
Sialic acid metabolism R-HSA-4085001 9.639558e-01 0.016 0 0
Collagen formation R-HSA-1474290 9.646553e-01 0.016 0 0
Glutathione conjugation R-HSA-156590 9.657034e-01 0.015 0 0
Metabolism of polyamines R-HSA-351202 9.657034e-01 0.015 0 0
tRNA Aminoacylation R-HSA-379724 9.657034e-01 0.015 0 0
rRNA processing R-HSA-72312 9.658969e-01 0.015 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.673665e-01 0.014 0 0
PLC beta mediated events R-HSA-112043 9.673665e-01 0.014 0 0
Collagen degradation R-HSA-1442490 9.673665e-01 0.014 0 0
Mitochondrial protein import R-HSA-1268020 9.689490e-01 0.014 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.689490e-01 0.014 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.689490e-01 0.014 0 0
Infectious disease R-HSA-5663205 9.717452e-01 0.012 1 0
Synthesis of bile acids and bile salts R-HSA-192105 9.725122e-01 0.012 0 0
Phospholipid metabolism R-HSA-1483257 9.736557e-01 0.012 0 0
Peptide ligand-binding receptors R-HSA-375276 9.740710e-01 0.011 0 0
G-protein mediated events R-HSA-112040 9.757833e-01 0.011 0 0
Nicotinate metabolism R-HSA-196807 9.757833e-01 0.011 0 0
Translation R-HSA-72766 9.769339e-01 0.010 0 0
O-linked glycosylation of mucins R-HSA-913709 9.769581e-01 0.010 0 0
Transcription of the HIV genome R-HSA-167172 9.769581e-01 0.010 0 0
Opioid Signalling R-HSA-111885 9.777461e-01 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.791396e-01 0.009 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.801517e-01 0.009 0 0
ECM proteoglycans R-HSA-3000178 9.801517e-01 0.009 0 0
Metal ion assimilation from the host R-HSA-9638482 9.801517e-01 0.009 0 0
Metabolism of porphyrins R-HSA-189445 9.801517e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.811148e-01 0.008 0 0
Purine catabolism R-HSA-74259 9.811148e-01 0.008 0 0
Bacterial Infection Pathways R-HSA-9824439 9.830323e-01 0.007 1 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.843527e-01 0.007 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.848388e-01 0.007 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.854756e-01 0.006 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.859886e-01 0.006 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.859886e-01 0.006 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.866687e-01 0.006 0 0
Keratinization R-HSA-6805567 9.871321e-01 0.006 0 0
Potential therapeutics for SARS R-HSA-9679191 9.895334e-01 0.005 0 0
Regulation of Complement cascade R-HSA-977606 9.920744e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.926644e-01 0.003 0 0
Disease R-HSA-1643685 9.926743e-01 0.003 1 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.939895e-01 0.003 0 0
FCGR activation R-HSA-2029481 9.939895e-01 0.003 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.946548e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.949570e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.950031e-01 0.002 0 0
Mitochondrial translation elongation R-HSA-5389840 9.950754e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.950754e-01 0.002 0 0
Mitochondrial translation initiation R-HSA-5368286 9.955425e-01 0.002 0 0
Regulation of insulin secretion R-HSA-422356 9.955425e-01 0.002 0 0
O-linked glycosylation R-HSA-5173105 9.958965e-01 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.965257e-01 0.002 0 0
Complement cascade R-HSA-166658 9.972464e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.975493e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.976953e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.983557e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.990966e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.991246e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.991805e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.992223e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.993305e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.995460e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.995495e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.995511e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.995549e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.996296e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.996451e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997256e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.997656e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.997880e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997915e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998098e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998106e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.998155e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.998349e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.998496e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999091e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999295e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999295e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999451e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999639e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999658e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999835e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999843e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999991e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999997e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999997e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.000000e+00 0.000 1 1
Uptake and function of anthrax toxins R-HSA-5210891 1.000000e+00 0.000 1 1
Uptake and actions of bacterial toxins R-HSA-5339562 1.000000e+00 0.000 1 0
Signaling by MAP2K mutants R-HSA-9652169 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 1.110223e-15 14.955 1 0
Cellular responses to stimuli R-HSA-8953897 4.662937e-15 14.331 0 0
Nervous system development R-HSA-9675108 5.995204e-15 14.222 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.010303e-14 13.996 1 0
Cell Cycle R-HSA-1640170 1.421085e-14 13.847 0 0
Cellular responses to stress R-HSA-2262752 1.609823e-14 13.793 0 0
Cellular response to heat stress R-HSA-3371556 4.274359e-14 13.369 0 0
Cell Cycle, Mitotic R-HSA-69278 8.659740e-14 13.062 0 0
Cellular Senescence R-HSA-2559583 8.544276e-13 12.068 0 0
Cell Cycle Checkpoints R-HSA-69620 4.144685e-12 11.383 0 0
M Phase R-HSA-68886 4.416578e-12 11.355 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.019473e-11 10.695 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.831136e-11 10.166 0 0
HSF1-dependent transactivation R-HSA-3371571 3.212552e-10 9.493 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.407764e-10 9.468 0 0
Signal Transduction R-HSA-162582 3.864851e-10 9.413 1 0
Cell-Cell communication R-HSA-1500931 5.127535e-10 9.290 0 0
Metabolism of RNA R-HSA-8953854 1.351969e-09 8.869 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.203802e-09 8.376 0 0
Mitotic Anaphase R-HSA-68882 7.217213e-09 8.142 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.509399e-09 8.070 0 0
Apoptotic execution phase R-HSA-75153 1.018587e-08 7.992 0 0
G2/M Checkpoints R-HSA-69481 1.139329e-08 7.943 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.412579e-08 7.850 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.663839e-08 7.779 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.318784e-08 7.635 1 0
Cell junction organization R-HSA-446728 2.428946e-08 7.615 0 0
Separation of Sister Chromatids R-HSA-2467813 2.518835e-08 7.599 0 0
MAPK family signaling cascades R-HSA-5683057 3.353301e-08 7.475 1 0
Post NMDA receptor activation events R-HSA-438064 3.561136e-08 7.448 0 0
Attenuation phase R-HSA-3371568 3.790085e-08 7.421 0 0
L1CAM interactions R-HSA-373760 3.736496e-08 7.428 1 0
Signaling by VEGF R-HSA-194138 4.834468e-08 7.316 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.900410e-08 7.051 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.096405e-07 6.960 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.449112e-07 6.839 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.449112e-07 6.839 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.525386e-07 6.817 0 0
Signaling by ALK in cancer R-HSA-9700206 1.525386e-07 6.817 0 0
Apoptosis R-HSA-109581 2.118950e-07 6.674 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.292752e-07 6.640 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.440469e-07 6.613 0 0
Signaling by ROBO receptors R-HSA-376176 3.571267e-07 6.447 0 0
Adherens junctions interactions R-HSA-418990 4.185603e-07 6.378 0 0
HSF1 activation R-HSA-3371511 4.567788e-07 6.340 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.803560e-07 6.318 1 1
Signaling downstream of RAS mutants R-HSA-9649948 4.803560e-07 6.318 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.803560e-07 6.318 1 1
mRNA Splicing R-HSA-72172 4.794076e-07 6.319 0 0
Signaling by RAS mutants R-HSA-6802949 4.803560e-07 6.318 1 0
Mitotic Prophase R-HSA-68875 5.335264e-07 6.273 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.393064e-07 6.268 0 0
Programmed Cell Death R-HSA-5357801 5.544090e-07 6.256 0 0
Cell-cell junction organization R-HSA-421270 5.981397e-07 6.223 0 0
Recycling pathway of L1 R-HSA-437239 6.653792e-07 6.177 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.538061e-07 6.123 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.075840e-06 5.968 1 1
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.129640e-06 5.947 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.298512e-06 5.887 1 1
DNA Replication Pre-Initiation R-HSA-69002 1.454791e-06 5.837 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.521169e-06 5.818 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.779422e-06 5.750 0 0
DNA Double Strand Break Response R-HSA-5693606 2.177915e-06 5.662 0 0
Gene expression (Transcription) R-HSA-74160 3.158068e-06 5.501 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.728295e-06 5.428 0 0
Regulation of CDH1 Function R-HSA-9764561 3.959944e-06 5.402 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.640931e-06 5.333 1 0
PTEN Regulation R-HSA-6807070 4.934328e-06 5.307 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.000080e-06 5.301 0 0
Signaling by NTRKs R-HSA-166520 5.163730e-06 5.287 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.504627e-06 5.259 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.556164e-06 5.255 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.103549e-06 5.214 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.209785e-06 5.207 1 0
Oncogenic MAPK signaling R-HSA-6802957 7.132150e-06 5.147 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.132150e-06 5.147 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.304315e-06 5.081 1 1
Regulation of PTEN gene transcription R-HSA-8943724 8.594764e-06 5.066 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.631218e-06 5.016 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.094676e-05 4.961 0 0
Chromatin organization R-HSA-4839726 1.126164e-05 4.948 0 0
Mitotic Prometaphase R-HSA-68877 1.187176e-05 4.925 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.418564e-05 4.848 0 0
MTOR signalling R-HSA-165159 1.595964e-05 4.797 0 0
Selective autophagy R-HSA-9663891 1.609424e-05 4.793 0 0
G2/M Transition R-HSA-69275 1.810738e-05 4.742 0 0
RET signaling R-HSA-8853659 2.017680e-05 4.695 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.017680e-05 4.695 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.076163e-05 4.683 0 0
Signaling by Hippo R-HSA-2028269 2.282888e-05 4.642 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.264647e-05 4.645 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.336167e-05 4.631 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.375289e-05 4.624 0 0
Signaling by ERBB2 R-HSA-1227986 2.388135e-05 4.622 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.649915e-05 4.577 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.211055e-05 4.493 0 0
MAP2K and MAPK activation R-HSA-5674135 3.707848e-05 4.431 1 1
DAG and IP3 signaling R-HSA-1489509 3.657308e-05 4.437 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.783573e-05 4.422 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.826795e-05 4.417 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.726059e-05 4.326 0 0
Semaphorin interactions R-HSA-373755 4.726059e-05 4.326 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.871642e-05 4.312 0 0
Ca-dependent events R-HSA-111996 4.871642e-05 4.312 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.955967e-05 4.225 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.977635e-05 4.223 0 0
Macroautophagy R-HSA-1632852 6.046220e-05 4.219 0 0
Calmodulin induced events R-HSA-111933 6.479302e-05 4.188 0 0
CaM pathway R-HSA-111997 6.479302e-05 4.188 0 0
mTORC1-mediated signalling R-HSA-166208 6.693502e-05 4.174 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.292789e-05 4.137 0 0
Deubiquitination R-HSA-5688426 6.830307e-05 4.166 0 0
Chromatin modifying enzymes R-HSA-3247509 7.358534e-05 4.133 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.839260e-05 4.106 0 0
MAP kinase activation R-HSA-450294 7.950179e-05 4.100 1 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.494891e-05 4.071 0 0
Developmental Biology R-HSA-1266738 8.511987e-05 4.070 1 0
TCF dependent signaling in response to WNT R-HSA-201681 8.563997e-05 4.067 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.599818e-05 4.066 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.642332e-05 4.063 0 0
S Phase R-HSA-69242 8.948461e-05 4.048 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 9.038678e-05 4.044 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.324477e-05 4.030 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.877930e-05 4.005 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.971039e-05 4.001 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.971039e-05 4.001 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.036563e-04 3.984 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.055120e-04 3.977 1 0
MyD88-independent TLR4 cascade R-HSA-166166 1.055120e-04 3.977 1 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.101486e-04 3.958 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.101486e-04 3.958 1 0
Processing of DNA double-strand break ends R-HSA-5693607 1.148839e-04 3.940 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.216987e-04 3.915 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.212604e-04 3.916 0 0
Signaling by PTK6 R-HSA-8848021 1.212604e-04 3.916 0 0
Autophagy R-HSA-9612973 1.286733e-04 3.891 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.302327e-04 3.885 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.345080e-04 3.871 0 0
RNA Polymerase II Transcription R-HSA-73857 1.370024e-04 3.863 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.452827e-04 3.838 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.458136e-04 3.836 0 0
Ephrin signaling R-HSA-3928664 1.468564e-04 3.833 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.475898e-04 3.831 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.644181e-04 3.784 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.703542e-04 3.769 0 0
Signaling by EGFR R-HSA-177929 1.808320e-04 3.743 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.808320e-04 3.743 0 0
Aggrephagy R-HSA-9646399 1.908482e-04 3.719 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.908482e-04 3.719 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.976261e-04 3.704 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.976261e-04 3.704 0 0
Orc1 removal from chromatin R-HSA-68949 1.976261e-04 3.704 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.004666e-04 3.698 0 0
Regulation of TP53 Activity R-HSA-5633007 2.093495e-04 3.679 0 0
EPH-Ephrin signaling R-HSA-2682334 2.094070e-04 3.679 0 0
Protein ubiquitination R-HSA-8852135 2.103603e-04 3.677 0 0
Regulation of signaling by CBL R-HSA-912631 2.155297e-04 3.666 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.200863e-04 3.657 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.453317e-04 3.610 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.453317e-04 3.610 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.462506e-04 3.609 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.372647e-04 3.625 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.372647e-04 3.625 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.462506e-04 3.609 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.237866e-04 3.650 1 0
Host Interactions of HIV factors R-HSA-162909 2.502624e-04 3.602 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.503387e-04 3.601 0 0
Degradation of DVL R-HSA-4641258 2.565470e-04 3.591 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.641554e-04 3.578 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.737708e-04 3.563 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.737708e-04 3.563 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.782537e-04 3.556 0 0
Signaling by WNT R-HSA-195721 2.804378e-04 3.552 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.848393e-04 3.545 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.904125e-04 3.537 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.904125e-04 3.537 0 0
Translation initiation complex formation R-HSA-72649 3.028602e-04 3.519 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.028602e-04 3.519 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.115936e-04 3.506 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.115936e-04 3.506 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.227136e-04 3.491 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.315862e-04 3.479 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.528739e-04 3.452 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.790438e-04 3.421 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.526169e-04 3.453 0 0
RAF activation R-HSA-5673000 3.446483e-04 3.463 1 1
PCP/CE pathway R-HSA-4086400 3.564997e-04 3.448 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.446483e-04 3.463 0 0
Stabilization of p53 R-HSA-69541 4.215988e-04 3.375 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.369850e-04 3.360 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.369850e-04 3.360 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.454531e-04 3.351 0 0
Regulation of Apoptosis R-HSA-169911 4.454531e-04 3.351 0 0
Signalling to ERKs R-HSA-187687 4.454531e-04 3.351 1 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.612031e-04 3.336 0 0
Interleukin-17 signaling R-HSA-448424 4.612031e-04 3.336 1 0
Spry regulation of FGF signaling R-HSA-1295596 4.761093e-04 3.322 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.820025e-04 3.317 0 0
PLC beta mediated events R-HSA-112043 4.914450e-04 3.309 0 0
mRNA 3'-end processing R-HSA-72187 5.055209e-04 3.296 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.215314e-04 3.283 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.597574e-04 3.252 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.968099e-04 3.224 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.968099e-04 3.224 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.055562e-04 3.218 0 0
DNA Replication R-HSA-69306 5.844523e-04 3.233 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.069960e-04 3.217 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.069960e-04 3.217 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.069960e-04 3.217 1 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.202138e-04 3.207 0 0
Josephin domain DUBs R-HSA-5689877 6.361926e-04 3.196 0 0
Regulation of PTEN localization R-HSA-8948747 6.538125e-04 3.185 0 0
Degradation of CDH1 R-HSA-9766229 6.878244e-04 3.163 0 0
HATs acetylate histones R-HSA-3214847 6.994195e-04 3.155 0 0
Signaling by Interleukins R-HSA-449147 7.166400e-04 3.145 1 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.862270e-04 3.104 0 0
Hedgehog 'off' state R-HSA-5610787 8.039584e-04 3.095 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.097302e-04 3.092 0 0
ESR-mediated signaling R-HSA-8939211 8.240347e-04 3.084 0 0
Homology Directed Repair R-HSA-5693538 8.524375e-04 3.069 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.771393e-04 3.057 0 0
HDACs deacetylate histones R-HSA-3214815 9.076117e-04 3.042 0 0
Generic Transcription Pathway R-HSA-212436 9.364209e-04 3.029 0 0
Diseases of programmed cell death R-HSA-9645723 9.388475e-04 3.027 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.445940e-04 3.025 0 0
Ub-specific processing proteases R-HSA-5689880 9.707245e-04 3.013 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.841585e-04 3.007 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.841585e-04 3.007 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.090751e-03 2.962 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.091988e-03 2.962 0 0
NRAGE signals death through JNK R-HSA-193648 1.091988e-03 2.962 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.097700e-03 2.960 1 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.107986e-03 2.955 1 1
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.108586e-03 2.955 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.129432e-03 2.947 0 0
RSK activation R-HSA-444257 1.129432e-03 2.947 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.141067e-03 2.943 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.141067e-03 2.943 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.339448e-03 2.873 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.339448e-03 2.873 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.268086e-03 2.897 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.268086e-03 2.897 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.242884e-03 2.906 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.242884e-03 2.906 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.398869e-03 2.854 0 0
G-protein mediated events R-HSA-112040 1.405137e-03 2.852 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.415673e-03 2.849 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.415673e-03 2.849 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.415673e-03 2.849 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.433070e-03 2.844 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.433070e-03 2.844 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.467749e-03 2.833 0 0
Neurodegenerative Diseases R-HSA-8863678 1.467749e-03 2.833 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.475324e-03 2.831 0 0
ERK/MAPK targets R-HSA-198753 1.475531e-03 2.831 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.475531e-03 2.831 0 0
Co-inhibition by PD-1 R-HSA-389948 1.535563e-03 2.814 0 0
FLT3 signaling in disease R-HSA-9682385 1.556518e-03 2.808 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.556518e-03 2.808 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.610608e-03 2.793 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.683366e-03 2.774 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.693926e-03 2.771 0 0
Signaling by NOTCH R-HSA-157118 1.714853e-03 2.766 0 0
TCR signaling R-HSA-202403 1.716888e-03 2.765 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.743882e-03 2.758 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.831845e-03 2.737 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.831845e-03 2.737 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.954481e-03 2.709 0 0
Degradation of AXIN R-HSA-4641257 1.933778e-03 2.714 0 0
Nucleosome assembly R-HSA-774815 1.898696e-03 2.722 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.898696e-03 2.722 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.022093e-03 2.694 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.184149e-03 2.661 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.917828e-03 2.717 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.917828e-03 2.717 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.252576e-03 2.647 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.250304e-03 2.648 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.933778e-03 2.714 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.933778e-03 2.714 0 0
G1/S Transition R-HSA-69206 2.183603e-03 2.661 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.898696e-03 2.722 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.126048e-03 2.672 0 0
Synthesis of DNA R-HSA-69239 2.256489e-03 2.647 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.294055e-03 2.639 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.311343e-03 2.636 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.311343e-03 2.636 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.323089e-03 2.634 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.384228e-03 2.623 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.475211e-03 2.606 0 0
Myogenesis R-HSA-525793 2.475211e-03 2.606 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.542431e-03 2.595 1 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.569227e-03 2.590 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.604400e-03 2.584 0 0
UCH proteinases R-HSA-5689603 2.611575e-03 2.583 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.617409e-03 2.582 0 0
Nuclear import of Rev protein R-HSA-180746 2.645512e-03 2.577 0 0
Mitophagy R-HSA-5205647 2.645512e-03 2.577 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.714870e-03 2.566 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.714870e-03 2.566 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.714870e-03 2.566 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.714870e-03 2.566 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.858803e-03 2.544 1 0
Pexophagy R-HSA-9664873 2.860379e-03 2.544 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.860379e-03 2.544 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.860379e-03 2.544 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.908342e-03 2.536 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.908342e-03 2.536 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.918274e-03 2.535 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.918274e-03 2.535 0 0
Signaling by SCF-KIT R-HSA-1433557 3.132288e-03 2.504 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.132288e-03 2.504 0 0
Frs2-mediated activation R-HSA-170968 3.341531e-03 2.476 1 1
Diseases of mitotic cell cycle R-HSA-9675126 3.625495e-03 2.441 0 0
Meiotic synapsis R-HSA-1221632 3.405189e-03 2.468 0 0
Metabolism of non-coding RNA R-HSA-194441 4.066113e-03 2.391 0 0
snRNP Assembly R-HSA-191859 4.066113e-03 2.391 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.016556e-03 2.396 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.016556e-03 2.396 0 0
Ribosome-associated quality control R-HSA-9948299 3.367161e-03 2.473 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.511266e-03 2.455 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.760592e-03 2.425 0 0
Signal transduction by L1 R-HSA-445144 3.511266e-03 2.455 1 1
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.985320e-03 2.400 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.526511e-03 2.453 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.497892e-03 2.456 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.302473e-03 2.481 1 0
HIV Infection R-HSA-162906 3.798459e-03 2.420 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.302473e-03 2.481 1 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.265040e-03 2.486 0 0
Death Receptor Signaling R-HSA-73887 3.494274e-03 2.457 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.292588e-03 2.482 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.998351e-03 2.398 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.547161e-03 2.450 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.447229e-03 2.463 1 0
Signaling by Hedgehog R-HSA-5358351 3.367161e-03 2.473 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.760592e-03 2.425 0 0
Membrane Trafficking R-HSA-199991 4.227845e-03 2.374 0 0
PECAM1 interactions R-HSA-210990 4.263562e-03 2.370 0 0
FLT3 Signaling R-HSA-9607240 4.282951e-03 2.368 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.282951e-03 2.368 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.320612e-03 2.364 0 0
Interferon Signaling R-HSA-913531 4.456411e-03 2.351 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.479664e-03 2.349 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.479664e-03 2.349 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.479664e-03 2.349 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.481399e-03 2.349 1 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.488834e-03 2.348 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.522651e-03 2.345 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.540657e-03 2.343 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.540657e-03 2.343 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.726537e-03 2.325 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.761723e-03 2.322 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.860114e-03 2.313 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.860114e-03 2.313 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.978468e-03 2.303 0 0
DNA methylation R-HSA-5334118 4.978468e-03 2.303 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.138487e-03 2.289 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.260727e-03 2.279 0 0
Formation of annular gap junctions R-HSA-196025 5.260727e-03 2.279 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.260727e-03 2.279 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.260727e-03 2.279 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.328325e-03 2.273 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.443019e-03 2.264 0 0
Long-term potentiation R-HSA-9620244 5.471876e-03 2.262 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.471876e-03 2.262 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.478309e-03 2.261 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.488820e-03 2.261 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.488820e-03 2.261 0 0
Signaling by FGFR1 R-HSA-5654736 5.494937e-03 2.260 0 0
Glycolysis R-HSA-70171 5.696874e-03 2.244 0 0
Cellular response to chemical stress R-HSA-9711123 5.767842e-03 2.239 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.834609e-03 2.234 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.934724e-03 2.227 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.935447e-03 2.227 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.977473e-03 2.223 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.069084e-03 2.217 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.133522e-03 2.212 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.153019e-03 2.211 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.260360e-03 2.203 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.371330e-03 2.196 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.386077e-03 2.195 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.386077e-03 2.195 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.671951e-03 2.176 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.671951e-03 2.176 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.852328e-03 2.164 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.929376e-03 2.159 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.104101e-03 2.148 0 0
Signaling by FGFR4 R-HSA-5654743 7.263795e-03 2.139 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.428385e-03 2.129 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.478046e-03 2.126 0 0
Influenza Infection R-HSA-168255 7.594135e-03 2.120 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.888658e-03 2.103 0 0
Gap junction degradation R-HSA-190873 7.888658e-03 2.103 0 0
Signaling by NOTCH4 R-HSA-9013694 7.981056e-03 2.098 0 0
Oncogene Induced Senescence R-HSA-2559585 8.048933e-03 2.094 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.127339e-03 2.090 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.375760e-03 2.077 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.490999e-03 2.071 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.490999e-03 2.071 0 0
Circadian clock R-HSA-9909396 8.511666e-03 2.070 0 0
Prolonged ERK activation events R-HSA-169893 8.532049e-03 2.069 1 0
Platelet activation, signaling and aggregation R-HSA-76002 8.551609e-03 2.068 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.555538e-03 2.068 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.562697e-03 2.067 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.179804e-03 2.037 0 0
GPVI-mediated activation cascade R-HSA-114604 9.640395e-03 2.016 0 0
CREB phosphorylation R-HSA-199920 9.759663e-03 2.011 0 0
Kinesins R-HSA-983189 9.800587e-03 2.009 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.914687e-03 2.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.914687e-03 2.004 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.102808e-02 1.958 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.102808e-02 1.958 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.102808e-02 1.958 1 1
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.174036e-02 1.930 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.041786e-02 1.982 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.130926e-02 1.947 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.077377e-02 1.968 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.325996e-02 1.877 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.041786e-02 1.982 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.266349e-02 1.897 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.134937e-02 1.945 0 0
Signaling by FGFR3 R-HSA-5654741 1.003945e-02 1.998 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.117637e-02 1.952 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.106831e-02 1.956 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.082860e-02 1.965 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.008998e-02 1.996 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.106831e-02 1.956 0 0
Hedgehog 'on' state R-HSA-5632684 1.058749e-02 1.975 0 0
Gene Silencing by RNA R-HSA-211000 1.313216e-02 1.882 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.425722e-02 1.846 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.438099e-02 1.842 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.438099e-02 1.842 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.525873e-02 1.816 0 0
Opioid Signalling R-HSA-111885 1.529872e-02 1.815 0 0
Smooth Muscle Contraction R-HSA-445355 1.538705e-02 1.813 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.539660e-02 1.813 0 0
Regulation of KIT signaling R-HSA-1433559 1.539660e-02 1.813 0 0
Signal regulatory protein family interactions R-HSA-391160 1.539660e-02 1.813 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.572936e-02 1.803 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.576339e-02 1.802 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.629229e-02 1.788 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.629229e-02 1.788 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.720161e-02 1.764 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.820628e-02 1.740 0 0
EGFR downregulation R-HSA-182971 1.823428e-02 1.739 0 0
Downstream signal transduction R-HSA-186763 1.823428e-02 1.739 0 0
Toll-like Receptor Cascades R-HSA-168898 1.837580e-02 1.736 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.858055e-02 1.731 0 0
Generation of second messenger molecules R-HSA-202433 1.858055e-02 1.731 0 0
Signaling by NOTCH1 R-HSA-1980143 1.902089e-02 1.721 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.902089e-02 1.721 0 0
Interleukin-12 signaling R-HSA-9020591 1.902089e-02 1.721 0 0
HIV Life Cycle R-HSA-162587 1.902431e-02 1.721 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.981552e-02 1.703 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.997894e-02 1.699 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.997894e-02 1.699 0 0
p38MAPK events R-HSA-171007 1.997894e-02 1.699 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.109813e-02 1.676 0 0
Packaging Of Telomere Ends R-HSA-171306 2.109813e-02 1.676 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.118597e-02 1.674 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.122825e-02 1.673 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.124107e-02 1.673 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.124107e-02 1.673 0 0
Signaling by AXIN mutants R-HSA-4839735 2.124107e-02 1.673 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.124107e-02 1.673 0 0
Activation of RAC1 R-HSA-428540 2.124107e-02 1.673 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.156815e-02 1.666 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.174026e-02 1.663 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.180929e-02 1.661 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.270174e-02 1.644 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.270977e-02 1.644 0 0
Peptide chain elongation R-HSA-156902 2.334479e-02 1.632 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.353896e-02 1.628 0 0
RNA Polymerase I Transcription R-HSA-73864 2.357837e-02 1.627 0 0
G alpha (12/13) signalling events R-HSA-416482 2.357837e-02 1.627 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.419413e-02 1.616 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.428700e-02 1.615 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.489986e-02 1.604 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.531489e-02 1.597 0 0
Negative regulation of FLT3 R-HSA-9706369 2.543557e-02 1.595 0 0
Phosphorylation of the APC/C R-HSA-176412 2.543557e-02 1.595 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.543557e-02 1.595 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.543557e-02 1.595 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.544630e-02 1.594 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.575563e-02 1.589 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.618121e-02 1.582 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.699159e-02 1.569 0 0
Meiosis R-HSA-1500620 2.728928e-02 1.564 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.787905e-02 1.555 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.787905e-02 1.555 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.787905e-02 1.555 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.787905e-02 1.555 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.787905e-02 1.555 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.794493e-02 1.554 0 0
Negative regulation of MET activity R-HSA-6807004 2.794493e-02 1.554 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.803455e-02 1.552 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.803455e-02 1.552 0 0
Maturation of protein E R-HSA-9683683 2.803455e-02 1.552 0 0
Maturation of protein E R-HSA-9694493 2.803455e-02 1.552 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.859640e-02 1.544 0 0
PKR-mediated signaling R-HSA-9833482 2.892696e-02 1.539 0 0
Signaling by FGFR2 R-HSA-5654738 2.892696e-02 1.539 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.917915e-02 1.535 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.927568e-02 1.533 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.927568e-02 1.533 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.930115e-02 1.533 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.931205e-02 1.533 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.931205e-02 1.533 0 0
Unwinding of DNA R-HSA-176974 2.931205e-02 1.533 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.974013e-02 1.527 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.315646e-02 1.479 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.315646e-02 1.479 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.315646e-02 1.479 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.315646e-02 1.479 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.315646e-02 1.479 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.315646e-02 1.479 0 0
Signaling by LTK in cancer R-HSA-9842640 4.031188e-02 1.395 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.910831e-02 1.408 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.910831e-02 1.408 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.575744e-02 1.447 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.575744e-02 1.447 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.183159e-02 1.497 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.493786e-02 1.347 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.922246e-02 1.406 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.396008e-02 1.469 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.079739e-02 1.389 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.116397e-02 1.385 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.497241e-02 1.456 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.497241e-02 1.456 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.075113e-02 1.390 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.394973e-02 1.357 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.110843e-02 1.386 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.964411e-02 1.402 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.615017e-02 1.442 0 0
Co-stimulation by CD28 R-HSA-389356 3.148274e-02 1.502 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.561185e-02 1.448 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.189443e-02 1.378 0 0
Ion homeostasis R-HSA-5578775 4.264021e-02 1.370 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.575744e-02 1.447 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.079739e-02 1.389 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.348121e-02 1.362 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.075113e-02 1.390 0 0
Signaling by FGFR R-HSA-190236 4.127760e-02 1.384 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.079739e-02 1.389 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.551707e-02 1.450 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.075113e-02 1.390 0 0
Signal attenuation R-HSA-74749 3.910831e-02 1.408 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.396008e-02 1.469 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.452827e-02 1.462 0 0
Gap junction trafficking and regulation R-HSA-157858 3.561185e-02 1.448 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.189443e-02 1.378 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.963602e-02 1.402 0 0
TNF signaling R-HSA-75893 4.264021e-02 1.370 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.575744e-02 1.447 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.183159e-02 1.497 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.394973e-02 1.357 0 0
DNA Repair R-HSA-73894 3.191122e-02 1.496 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.910831e-02 1.408 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.394973e-02 1.357 0 0
Nef and signal transduction R-HSA-164944 4.031188e-02 1.395 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.493786e-02 1.347 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.394973e-02 1.357 0 0
Signalling to RAS R-HSA-167044 3.396008e-02 1.469 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.206844e-02 1.376 0 0
Cellular response to hypoxia R-HSA-1234174 3.428289e-02 1.465 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.483735e-02 1.458 0 0
Signaling by ALK R-HSA-201556 3.372177e-02 1.472 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.115111e-02 1.507 0 0
tRNA processing in the nucleus R-HSA-6784531 4.478545e-02 1.349 0 0
Glucose metabolism R-HSA-70326 3.706563e-02 1.431 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.452827e-02 1.462 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.493786e-02 1.347 1 1
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.242847e-02 1.489 0 0
Meiotic recombination R-HSA-912446 4.501202e-02 1.347 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.501202e-02 1.347 0 0
Regulated Necrosis R-HSA-5218859 4.659951e-02 1.332 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.715150e-02 1.327 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.715150e-02 1.327 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.741183e-02 1.324 0 0
PKA activation in glucagon signalling R-HSA-164378 4.765275e-02 1.322 0 0
Polo-like kinase mediated events R-HSA-156711 4.765275e-02 1.322 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.765275e-02 1.322 0 0
PKA activation R-HSA-163615 4.765275e-02 1.322 0 0
Platelet sensitization by LDL R-HSA-432142 4.765275e-02 1.322 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.765275e-02 1.322 0 0
Signaling by ERBB4 R-HSA-1236394 4.812399e-02 1.318 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.817926e-02 1.317 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.817926e-02 1.317 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.849215e-02 1.314 0 0
Signaling by MET R-HSA-6806834 4.939520e-02 1.306 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.979444e-02 1.303 0 0
Signaling by APC mutants R-HSA-4839744 5.067955e-02 1.295 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.067955e-02 1.295 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.067955e-02 1.295 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.067955e-02 1.295 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.067955e-02 1.295 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.067955e-02 1.295 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.103088e-02 1.292 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.129979e-02 1.290 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.209085e-02 1.283 0 0
Signaling by TGFB family members R-HSA-9006936 5.231501e-02 1.281 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.419514e-02 1.266 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.419514e-02 1.266 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.454356e-02 1.263 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.454356e-02 1.263 0 0
Regulation of gap junction activity R-HSA-191650 5.454356e-02 1.263 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.454356e-02 1.263 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.454356e-02 1.263 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.505497e-02 1.259 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.519173e-02 1.258 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.519173e-02 1.258 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.519173e-02 1.258 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.519173e-02 1.258 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.546222e-02 1.256 0 0
DCC mediated attractive signaling R-HSA-418885 5.546222e-02 1.256 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.546222e-02 1.256 0 0
p75NTR signals via NF-kB R-HSA-193639 5.546222e-02 1.256 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.614782e-02 1.251 0 0
Depyrimidination R-HSA-73928 5.614782e-02 1.251 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.626987e-02 1.250 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.707206e-02 1.244 0 0
Rap1 signalling R-HSA-392517 5.715533e-02 1.243 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.730960e-02 1.242 0 0
Interleukin-12 family signaling R-HSA-447115 5.965876e-02 1.224 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.217111e-02 1.206 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.302315e-02 1.200 0 0
Defective pyroptosis R-HSA-9710421 6.302315e-02 1.200 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.405046e-02 1.193 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.405046e-02 1.193 0 0
NF-kB is activated and signals survival R-HSA-209560 6.405046e-02 1.193 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.405046e-02 1.193 0 0
Late endosomal microautophagy R-HSA-9615710 6.447290e-02 1.191 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.447290e-02 1.191 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.655679e-02 1.177 0 0
Deadenylation of mRNA R-HSA-429947 6.655679e-02 1.177 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.735220e-02 1.172 0 0
Killing mechanisms R-HSA-9664420 6.735220e-02 1.172 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.735220e-02 1.172 0 0
Nephrin family interactions R-HSA-373753 6.775078e-02 1.169 0 0
Glycogen synthesis R-HSA-3322077 6.775078e-02 1.169 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.809115e-02 1.167 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.809115e-02 1.167 0 0
ABC transporter disorders R-HSA-5619084 6.858077e-02 1.164 0 0
Signaling by NOTCH3 R-HSA-9012852 6.875112e-02 1.163 0 0
Proteasome assembly R-HSA-9907900 7.043124e-02 1.152 0 0
Gap junction trafficking R-HSA-190828 7.043124e-02 1.152 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.051602e-02 1.152 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.077461e-02 1.150 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.236129e-02 1.140 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.263459e-02 1.139 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.263459e-02 1.139 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.263459e-02 1.139 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.263459e-02 1.139 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.263459e-02 1.139 0 0
HCMV Early Events R-HSA-9609690 7.335319e-02 1.135 0 0
Activation of the pre-replicative complex R-HSA-68962 7.378284e-02 1.132 0 0
Downstream TCR signaling R-HSA-202424 7.557735e-02 1.122 0 0
ABC-family proteins mediated transport R-HSA-382556 7.590025e-02 1.120 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.695770e-02 1.114 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.831853e-02 1.106 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 7.831853e-02 1.106 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.831853e-02 1.106 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.831853e-02 1.106 0 0
Somitogenesis R-HSA-9824272 7.838026e-02 1.106 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.920952e-02 1.101 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.920952e-02 1.101 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.920952e-02 1.101 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.920952e-02 1.101 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.920952e-02 1.101 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.920952e-02 1.101 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.920952e-02 1.101 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.060945e-02 1.094 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.060945e-02 1.094 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.060945e-02 1.094 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.073921e-02 1.093 0 0
Selenocysteine synthesis R-HSA-2408557 8.145176e-02 1.089 0 0
Interleukin-1 signaling R-HSA-9020702 8.145176e-02 1.089 1 0
Eukaryotic Translation Termination R-HSA-72764 8.153457e-02 1.089 0 0
Trafficking of AMPA receptors R-HSA-399719 8.387940e-02 1.076 0 0
Budding and maturation of HIV virion R-HSA-162588 8.387940e-02 1.076 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.515587e-02 1.070 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.680647e-02 1.061 0 0
Amyloid fiber formation R-HSA-977225 8.731830e-02 1.059 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.827771e-02 1.054 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.827771e-02 1.054 0 0
SARS-CoV Infections R-HSA-9679506 8.838658e-02 1.054 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.934435e-02 1.049 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.934435e-02 1.049 0 0
Muscle contraction R-HSA-397014 9.081269e-02 1.042 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.224040e-02 1.035 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.224040e-02 1.035 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.224040e-02 1.035 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.224040e-02 1.035 0 0
Insulin receptor signalling cascade R-HSA-74751 9.249701e-02 1.034 0 0
Calcineurin activates NFAT R-HSA-2025928 9.253165e-02 1.034 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.253165e-02 1.034 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.253165e-02 1.034 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.339898e-02 1.030 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.427649e-02 1.026 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.521624e-02 1.021 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.521624e-02 1.021 0 0
Glycogen storage diseases R-HSA-3229121 9.521624e-02 1.021 0 0
Interleukin-1 family signaling R-HSA-446652 9.570432e-02 1.019 1 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.592017e-02 1.018 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.611180e-02 1.017 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.611180e-02 1.017 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.611180e-02 1.017 0 0
Cleavage of the damaged purine R-HSA-110331 9.953074e-02 1.002 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.005114e-01 0.998 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.005114e-01 0.998 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.009947e-01 0.996 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.318098e-01 0.880 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.318098e-01 0.880 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.318098e-01 0.880 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.318098e-01 0.880 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.318098e-01 0.880 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.318098e-01 0.880 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.318098e-01 0.880 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.318098e-01 0.880 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.318098e-01 0.880 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.318098e-01 0.880 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.318098e-01 0.880 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.318098e-01 0.880 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.318098e-01 0.880 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.318098e-01 0.880 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.318098e-01 0.880 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.318098e-01 0.880 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.318098e-01 0.880 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.318098e-01 0.880 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.318098e-01 0.880 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.318098e-01 0.880 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.318098e-01 0.880 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.318098e-01 0.880 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.318098e-01 0.880 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.318098e-01 0.880 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.318098e-01 0.880 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.318098e-01 0.880 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.318098e-01 0.880 0 0
Regulation of TP53 Expression R-HSA-6804754 1.106148e-01 0.956 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.106148e-01 0.956 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.106148e-01 0.956 0 0
Signalling to ERK5 R-HSA-198765 1.106148e-01 0.956 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.106148e-01 0.956 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.581216e-01 0.801 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.581216e-01 0.801 0 0
MET interacts with TNS proteins R-HSA-8875513 1.581216e-01 0.801 0 0
MET activates PTPN11 R-HSA-8865999 1.581216e-01 0.801 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.058027e-01 0.976 0 0
STAT5 Activation R-HSA-9645135 1.364565e-01 0.865 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.364565e-01 0.865 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.364565e-01 0.865 0 0
PI3K/AKT activation R-HSA-198203 1.147180e-01 0.940 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.147180e-01 0.940 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.697058e-01 0.770 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.697058e-01 0.770 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.697058e-01 0.770 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.697058e-01 0.770 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.697058e-01 0.770 0 0
SOS-mediated signalling R-HSA-112412 1.697058e-01 0.770 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.389853e-01 0.857 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.146826e-01 0.941 0 0
ERKs are inactivated R-HSA-202670 1.650947e-01 0.782 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.650947e-01 0.782 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.348216e-01 0.870 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.348216e-01 0.870 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.348216e-01 0.870 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.348216e-01 0.870 0 0
GAB1 signalosome R-HSA-180292 1.111367e-01 0.954 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.564071e-01 0.806 0 0
Repression of WNT target genes R-HSA-4641265 1.927869e-01 0.715 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.927869e-01 0.715 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.466933e-01 0.834 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.793005e-01 0.746 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.064297e-01 0.973 0 0
Signaling by Erythropoietin R-HSA-9006335 1.276569e-01 0.894 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.033507e-01 0.692 0 0
DAP12 signaling R-HSA-2424491 1.425182e-01 0.846 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.866927e-01 0.729 0 0
Dual Incision in GG-NER R-HSA-5696400 1.320584e-01 0.879 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.717027e-01 0.765 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.084010e-01 0.965 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.084010e-01 0.965 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.084010e-01 0.965 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.084010e-01 0.965 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.084010e-01 0.965 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.918077e-01 0.717 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.090729e-01 0.962 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.179317e-01 0.928 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.376288e-01 0.861 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.376288e-01 0.861 0 0
Centrosome maturation R-HSA-380287 1.362207e-01 0.866 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.079824e-01 0.967 0 0
Viral mRNA Translation R-HSA-192823 1.374326e-01 0.862 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.313504e-01 0.882 0 0
G0 and Early G1 R-HSA-1538133 1.746387e-01 0.758 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.090859e-01 0.962 0 0
Cyclin D associated events in G1 R-HSA-69231 1.248375e-01 0.904 0 0
G1 Phase R-HSA-69236 1.248375e-01 0.904 0 0
Formation of definitive endoderm R-HSA-9823730 1.466933e-01 0.834 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.176951e-01 0.929 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.020060e-01 0.991 0 0
Formation of apoptosome R-HSA-111458 1.147180e-01 0.940 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.349084e-01 0.870 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.020060e-01 0.991 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.020060e-01 0.991 0 0
Cellular response to starvation R-HSA-9711097 1.741944e-01 0.759 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.903629e-01 0.720 0 0
IRS-mediated signalling R-HSA-112399 1.378231e-01 0.861 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.716168e-01 0.765 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.175123e-01 0.930 0 0
TGFBR3 expression R-HSA-9839394 1.538871e-01 0.813 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.364565e-01 0.865 0 0
Protein folding R-HSA-391251 1.411190e-01 0.850 0 0
Chromosome Maintenance R-HSA-73886 1.094278e-01 0.961 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.147180e-01 0.940 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.147180e-01 0.940 0 0
Integrin signaling R-HSA-354192 1.064297e-01 0.973 0 0
PI3K Cascade R-HSA-109704 1.263319e-01 0.898 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.310286e-01 0.883 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.348216e-01 0.870 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.369807e-01 0.863 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.686986e-01 0.773 0 0
Signaling by PDGF R-HSA-186797 1.980612e-01 0.703 0 0
IGF1R signaling cascade R-HSA-2428924 1.482551e-01 0.829 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.378231e-01 0.861 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.364565e-01 0.865 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.564071e-01 0.806 0 0
Signaling by NODAL R-HSA-1181150 1.466933e-01 0.834 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.639914e-01 0.785 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.127748e-01 0.948 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.564071e-01 0.806 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.605872e-01 0.794 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.593090e-01 0.798 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.146826e-01 0.941 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.466933e-01 0.834 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.136449e-01 0.944 0 0
DARPP-32 events R-HSA-180024 1.276569e-01 0.894 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.242357e-01 0.906 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.793005e-01 0.746 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.276569e-01 0.894 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.472171e-01 0.832 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.697058e-01 0.770 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.271475e-01 0.896 0 0
FasL/ CD95L signaling R-HSA-75157 1.581216e-01 0.801 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.058027e-01 0.976 0 0
Signaling by LTK R-HSA-9842663 1.927869e-01 0.715 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.918402e-01 0.717 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.918077e-01 0.717 0 0
Suppression of apoptosis R-HSA-9635465 1.389853e-01 0.857 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.064297e-01 0.973 0 0
ER-Phagosome pathway R-HSA-1236974 1.617087e-01 0.791 0 0
RUNX2 regulates bone development R-HSA-8941326 1.606084e-01 0.794 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.581216e-01 0.801 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.058027e-01 0.976 0 0
Bicarbonate transporters R-HSA-425381 1.389853e-01 0.857 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.650947e-01 0.782 0 0
Netrin-1 signaling R-HSA-373752 1.248375e-01 0.904 0 0
NGF-stimulated transcription R-HSA-9031628 1.754191e-01 0.756 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.375078e-01 0.862 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.425182e-01 0.846 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.949149e-01 0.710 0 0
Interleukin-2 family signaling R-HSA-451927 1.349084e-01 0.870 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.918077e-01 0.717 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.176951e-01 0.929 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.509954e-01 0.821 0 0
Reproduction R-HSA-1474165 1.934370e-01 0.713 0 0
Base Excision Repair R-HSA-73884 1.716168e-01 0.765 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.064297e-01 0.973 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.492724e-01 0.826 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.242357e-01 0.906 0 0
Signaling by Leptin R-HSA-2586552 1.147180e-01 0.940 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.482551e-01 0.829 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.033507e-01 0.692 1 1
Response of Mtb to phagocytosis R-HSA-9637690 1.136250e-01 0.945 0 0
Interleukin-37 signaling R-HSA-9008059 1.425182e-01 0.846 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.224503e-01 0.912 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.793005e-01 0.746 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.927869e-01 0.715 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.927869e-01 0.715 0 0
Growth hormone receptor signaling R-HSA-982772 1.210402e-01 0.917 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.271475e-01 0.896 0 0
Inositol phosphate metabolism R-HSA-1483249 1.689434e-01 0.772 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.661819e-01 0.779 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.742334e-01 0.759 0 0
Depurination R-HSA-73927 1.106532e-01 0.956 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.518590e-01 0.819 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.049756e-01 0.688 0 0
Type I hemidesmosome assembly R-HSA-446107 2.049756e-01 0.688 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.049756e-01 0.688 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 2.049756e-01 0.688 0 0
RMTs methylate histone arginines R-HSA-3214858 2.063605e-01 0.685 0 0
Gastrulation R-HSA-9758941 2.065041e-01 0.685 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.081262e-01 0.682 1 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.081262e-01 0.682 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.081262e-01 0.682 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.081262e-01 0.682 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.081262e-01 0.682 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.083676e-01 0.681 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.083676e-01 0.681 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.085604e-01 0.681 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.085604e-01 0.681 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.085604e-01 0.681 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.085604e-01 0.681 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.085604e-01 0.681 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.085604e-01 0.681 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.085604e-01 0.681 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.085604e-01 0.681 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.085604e-01 0.681 0 0
Striated Muscle Contraction R-HSA-390522 2.096472e-01 0.679 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.096472e-01 0.679 0 0
Potential therapeutics for SARS R-HSA-9679191 2.151744e-01 0.667 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.208948e-01 0.656 0 0
Formation of axial mesoderm R-HSA-9796292 2.217928e-01 0.654 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.217928e-01 0.654 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.217928e-01 0.654 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.222819e-01 0.653 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.237863e-01 0.650 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.254448e-01 0.647 0 0
Glycogen metabolism R-HSA-8982491 2.254448e-01 0.647 0 0
Nucleotide Excision Repair R-HSA-5696398 2.263966e-01 0.645 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.277396e-01 0.643 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.281002e-01 0.642 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.281002e-01 0.642 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.281002e-01 0.642 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.283983e-01 0.641 0 0
Apoptotic factor-mediated response R-HSA-111471 2.283983e-01 0.641 0 0
Transmission across Chemical Synapses R-HSA-112315 2.296958e-01 0.639 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.299288e-01 0.638 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.299288e-01 0.638 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.299288e-01 0.638 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.299288e-01 0.638 0 0
Adaptive Immune System R-HSA-1280218 2.302588e-01 0.638 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.303759e-01 0.638 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.303759e-01 0.638 0 0
Syndecan interactions R-HSA-3000170 2.303759e-01 0.638 0 0
MHC class II antigen presentation R-HSA-2132295 2.313357e-01 0.636 0 0
Neurexins and neuroligins R-HSA-6794361 2.341666e-01 0.630 0 0
Signaling by TGFBR3 R-HSA-9839373 2.386658e-01 0.622 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.417128e-01 0.617 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.417128e-01 0.617 0 0
Lipophagy R-HSA-9613354 2.417128e-01 0.617 0 0
WNT mediated activation of DVL R-HSA-201688 2.417128e-01 0.617 0 0
MAPK1 (ERK2) activation R-HSA-112411 2.417128e-01 0.617 0 0
ALK mutants bind TKIs R-HSA-9700645 2.417128e-01 0.617 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.417128e-01 0.617 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.417128e-01 0.617 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.430250e-01 0.614 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.441673e-01 0.612 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.462525e-01 0.609 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.462525e-01 0.609 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.462525e-01 0.609 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.462525e-01 0.609 0 0
Inhibition of PKR R-HSA-169131 2.462525e-01 0.609 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.471064e-01 0.607 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.471064e-01 0.607 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.471064e-01 0.607 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.479499e-01 0.606 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.499232e-01 0.602 0 0
Activation of BH3-only proteins R-HSA-114452 2.506785e-01 0.601 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.518408e-01 0.599 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.518408e-01 0.599 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.518408e-01 0.599 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.533311e-01 0.596 0 0
Translesion Synthesis by POLH R-HSA-110320 2.542789e-01 0.595 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.542789e-01 0.595 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.598785e-01 0.585 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.603338e-01 0.584 0 0
Activation of AKT2 R-HSA-165158 2.603338e-01 0.584 0 0
IRS activation R-HSA-74713 2.603338e-01 0.584 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.603338e-01 0.584 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.603338e-01 0.584 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.603338e-01 0.584 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.603338e-01 0.584 0 0
Pyrophosphate hydrolysis R-HSA-71737 2.603338e-01 0.584 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.603338e-01 0.584 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.603338e-01 0.584 0 0
Reelin signalling pathway R-HSA-8866376 2.603338e-01 0.584 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.603338e-01 0.584 0 0
NrCAM interactions R-HSA-447038 2.603338e-01 0.584 0 0
Co-inhibition by BTLA R-HSA-9927353 2.603338e-01 0.584 0 0
Vesicle-mediated transport R-HSA-5653656 2.711269e-01 0.567 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.719632e-01 0.565 0 0
GPER1 signaling R-HSA-9634597 2.726604e-01 0.564 0 0
Telomere Maintenance R-HSA-157579 2.734418e-01 0.563 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.756437e-01 0.560 0 0
Signaling by FGFR in disease R-HSA-1226099 2.756437e-01 0.560 0 0
Tight junction interactions R-HSA-420029 2.768780e-01 0.558 0 0
HDMs demethylate histones R-HSA-3214842 2.768780e-01 0.558 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.794016e-01 0.554 1 1
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.794016e-01 0.554 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.794016e-01 0.554 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.794016e-01 0.554 0 0
Regulation of CDH11 function R-HSA-9762292 2.794016e-01 0.554 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.794016e-01 0.554 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.794945e-01 0.554 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.794945e-01 0.554 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.808268e-01 0.552 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.808268e-01 0.552 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.824886e-01 0.549 0 0
Erythropoietin activates RAS R-HSA-9027284 2.826645e-01 0.549 0 0
Translesion synthesis by REV1 R-HSA-110312 2.826645e-01 0.549 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.826645e-01 0.549 0 0
Signaling by Activin R-HSA-1502540 2.826645e-01 0.549 0 0
Protein methylation R-HSA-8876725 2.826645e-01 0.549 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.826645e-01 0.549 0 0
Platelet degranulation R-HSA-114608 2.841506e-01 0.546 0 0
HCMV Infection R-HSA-9609646 2.865773e-01 0.543 0 0
DNA Damage Bypass R-HSA-73893 2.901869e-01 0.537 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.901869e-01 0.537 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.909410e-01 0.536 0 0
Signaling by WNT in cancer R-HSA-4791275 2.936984e-01 0.532 0 0
DNA strand elongation R-HSA-69190 2.936984e-01 0.532 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.992256e-01 0.524 0 0
Metalloprotease DUBs R-HSA-5689901 3.009023e-01 0.522 0 0
Viral Infection Pathways R-HSA-9824446 3.025598e-01 0.519 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.068050e-01 0.513 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.078781e-01 0.512 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.078781e-01 0.512 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.078781e-01 0.512 0 0
Basigin interactions R-HSA-210991 3.078781e-01 0.512 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.078781e-01 0.512 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.122142e-01 0.506 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.122142e-01 0.506 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.122142e-01 0.506 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.122142e-01 0.506 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.122142e-01 0.506 0 0
Signaling by MAPK mutants R-HSA-9652817 3.122142e-01 0.506 0 0
TRAIL signaling R-HSA-75158 3.122142e-01 0.506 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.122142e-01 0.506 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.122142e-01 0.506 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.122142e-01 0.506 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.140071e-01 0.503 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.140071e-01 0.503 0 0
Translesion synthesis by POLI R-HSA-5656121 3.140071e-01 0.503 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.140071e-01 0.503 0 0
Regulation of BACH1 activity R-HSA-9708530 3.140071e-01 0.503 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.142379e-01 0.503 0 0
G-protein beta:gamma signalling R-HSA-397795 3.157989e-01 0.501 0 0
Nuclear RNA decay R-HSA-9930044 3.157989e-01 0.501 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.157989e-01 0.501 0 0
Leishmania infection R-HSA-9658195 3.166306e-01 0.499 0 0
Parasitic Infection Pathways R-HSA-9824443 3.166306e-01 0.499 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.175727e-01 0.498 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.175727e-01 0.498 0 0
Hemostasis R-HSA-109582 3.207810e-01 0.494 0 0
Ion transport by P-type ATPases R-HSA-936837 3.232501e-01 0.490 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.245482e-01 0.489 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.252902e-01 0.488 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.252902e-01 0.488 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.252902e-01 0.488 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.352730e-01 0.475 0 0
Assembly Of The HIV Virion R-HSA-175474 3.352730e-01 0.475 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.366856e-01 0.473 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.394555e-01 0.469 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.443573e-01 0.463 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.456153e-01 0.461 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.456153e-01 0.461 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.456153e-01 0.461 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.456153e-01 0.461 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.456153e-01 0.461 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 3.456153e-01 0.461 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.456153e-01 0.461 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.456153e-01 0.461 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.456153e-01 0.461 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.456153e-01 0.461 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.456153e-01 0.461 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.456153e-01 0.461 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.456153e-01 0.461 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 3.456153e-01 0.461 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.456153e-01 0.461 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.456153e-01 0.461 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.456153e-01 0.461 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.456153e-01 0.461 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.456153e-01 0.461 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.456153e-01 0.461 0 0
Inhibition of membrane repair R-HSA-9635644 3.456153e-01 0.461 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.456264e-01 0.461 0 0
Translesion synthesis by POLK R-HSA-5655862 3.456264e-01 0.461 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.456264e-01 0.461 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.456264e-01 0.461 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.456264e-01 0.461 0 0
Sensory processing of sound R-HSA-9659379 3.499181e-01 0.456 0 0
Peroxisomal protein import R-HSA-9033241 3.508068e-01 0.455 0 0
Regulation of beta-cell development R-HSA-186712 3.508068e-01 0.455 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.558088e-01 0.449 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.558088e-01 0.449 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.558088e-01 0.449 0 0
Integration of provirus R-HSA-162592 3.558088e-01 0.449 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.558088e-01 0.449 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.558088e-01 0.449 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.561979e-01 0.448 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.607578e-01 0.443 0 0
Gap junction assembly R-HSA-190861 3.607578e-01 0.443 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.607578e-01 0.443 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.627954e-01 0.440 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.628579e-01 0.440 0 0
FGFR2 alternative splicing R-HSA-6803529 3.628579e-01 0.440 0 0
Notch-HLH transcription pathway R-HSA-350054 3.628579e-01 0.440 0 0
Signaling by KIT in disease R-HSA-9669938 3.628579e-01 0.440 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.632743e-01 0.440 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.632743e-01 0.440 0 0
Metabolism of polyamines R-HSA-351202 3.683308e-01 0.434 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.691383e-01 0.433 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.691383e-01 0.433 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.747135e-01 0.426 0 0
Platelet calcium homeostasis R-HSA-418360 3.747135e-01 0.426 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.758453e-01 0.425 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.772975e-01 0.423 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.772975e-01 0.423 0 0
Specification of primordial germ cells R-HSA-9827857 3.772975e-01 0.423 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.904873e-01 0.408 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.932477e-01 0.405 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.937460e-01 0.405 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.937460e-01 0.405 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.937460e-01 0.405 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 3.937460e-01 0.405 0 0
Regulation of IFNG signaling R-HSA-877312 3.937460e-01 0.405 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.937460e-01 0.405 0 0
Immune System R-HSA-168256 3.944115e-01 0.404 1 0
Mitochondrial biogenesis R-HSA-1592230 3.951604e-01 0.403 0 0
Developmental Cell Lineages R-HSA-9734767 3.960755e-01 0.402 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.995366e-01 0.398 0 0
Heme signaling R-HSA-9707616 4.036480e-01 0.394 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.036480e-01 0.394 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.065459e-01 0.391 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.067579e-01 0.391 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.079661e-01 0.389 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.088146e-01 0.388 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.088146e-01 0.388 0 0
Tie2 Signaling R-HSA-210993 4.088146e-01 0.388 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.088146e-01 0.388 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.128291e-01 0.384 0 0
Disinhibition of SNARE formation R-HSA-114516 4.128291e-01 0.384 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.128291e-01 0.384 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.128291e-01 0.384 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.128291e-01 0.384 0 0
Netrin mediated repulsion signals R-HSA-418886 4.128291e-01 0.384 0 0
CHL1 interactions R-HSA-447041 4.128291e-01 0.384 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.128291e-01 0.384 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.128291e-01 0.384 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.128291e-01 0.384 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.128291e-01 0.384 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.155446e-01 0.381 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.186335e-01 0.378 0 0
HCMV Late Events R-HSA-9610379 4.258606e-01 0.371 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.310735e-01 0.365 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.310735e-01 0.365 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.310735e-01 0.365 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.310735e-01 0.365 0 0
Maturation of nucleoprotein R-HSA-9683610 4.310735e-01 0.365 0 0
Interleukin-6 signaling R-HSA-1059683 4.310735e-01 0.365 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.310735e-01 0.365 0 0
PI Metabolism R-HSA-1483255 4.311929e-01 0.365 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.318846e-01 0.365 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.318846e-01 0.365 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.318846e-01 0.365 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.318846e-01 0.365 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.318846e-01 0.365 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.318846e-01 0.365 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.318846e-01 0.365 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.318846e-01 0.365 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.318846e-01 0.365 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.318846e-01 0.365 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.318846e-01 0.365 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.318846e-01 0.365 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.318846e-01 0.365 0 0
Diseases of cellular response to stress R-HSA-9675132 4.318846e-01 0.365 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.318846e-01 0.365 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.318846e-01 0.365 0 0
TBC/RABGAPs R-HSA-8854214 4.323478e-01 0.364 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.399928e-01 0.357 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.399928e-01 0.357 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.399928e-01 0.357 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.405747e-01 0.356 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.453451e-01 0.351 0 0
Interleukin-7 signaling R-HSA-1266695 4.453451e-01 0.351 0 0
DAP12 interactions R-HSA-2172127 4.533263e-01 0.344 0 0
Dual incision in TC-NER R-HSA-6782135 4.558701e-01 0.341 0 0
Regulation by c-FLIP R-HSA-3371378 4.603884e-01 0.337 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.603884e-01 0.337 0 0
phospho-PLA2 pathway R-HSA-111995 4.603884e-01 0.337 0 0
Dimerization of procaspase-8 R-HSA-69416 4.603884e-01 0.337 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.603884e-01 0.337 0 0
MET receptor recycling R-HSA-8875656 4.603884e-01 0.337 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.603884e-01 0.337 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.603884e-01 0.337 0 0
Adrenoceptors R-HSA-390696 4.603884e-01 0.337 0 0
Co-stimulation by ICOS R-HSA-9927354 4.603884e-01 0.337 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.603884e-01 0.337 0 0
Sodium/Proton exchangers R-HSA-425986 4.603884e-01 0.337 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.675313e-01 0.330 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.675313e-01 0.330 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.675313e-01 0.330 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.675313e-01 0.330 0 0
HDL assembly R-HSA-8963896 4.675313e-01 0.330 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.706682e-01 0.327 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.706682e-01 0.327 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.706682e-01 0.327 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.706682e-01 0.327 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.706682e-01 0.327 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.706682e-01 0.327 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.723328e-01 0.326 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.723328e-01 0.326 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.733515e-01 0.325 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.733515e-01 0.325 0 0
Signaling by Insulin receptor R-HSA-74752 4.737777e-01 0.324 0 0
RAS processing R-HSA-9648002 4.738485e-01 0.324 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.741652e-01 0.324 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.741652e-01 0.324 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.741652e-01 0.324 0 0
FOXO-mediated transcription R-HSA-9614085 4.879926e-01 0.312 0 0
Cilium Assembly R-HSA-5617833 4.909177e-01 0.309 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.948128e-01 0.306 0 0
Diseases of DNA repair R-HSA-9675135 4.948128e-01 0.306 0 0
Integration of energy metabolism R-HSA-163685 4.966033e-01 0.304 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.973468e-01 0.303 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.973468e-01 0.303 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.988846e-01 0.302 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.006980e-01 0.300 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.029071e-01 0.299 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.029071e-01 0.299 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.029071e-01 0.299 0 0
Selenoamino acid metabolism R-HSA-2408522 5.047717e-01 0.297 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.056173e-01 0.296 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 5.056173e-01 0.296 0 0
CASP8 activity is inhibited R-HSA-5218900 5.056173e-01 0.296 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.056173e-01 0.296 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.056173e-01 0.296 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.056173e-01 0.296 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 5.056173e-01 0.296 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.056173e-01 0.296 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.056173e-01 0.296 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.056173e-01 0.296 0 0
ARMS-mediated activation R-HSA-170984 5.056173e-01 0.296 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.056173e-01 0.296 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.067851e-01 0.295 0 0
PLC-gamma1 signalling R-HSA-167021 5.067851e-01 0.295 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.067851e-01 0.295 0 0
Axonal growth stimulation R-HSA-209563 5.067851e-01 0.295 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.067851e-01 0.295 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.067851e-01 0.295 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 5.067851e-01 0.295 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.067851e-01 0.295 0 0
Invadopodia formation R-HSA-8941237 5.067851e-01 0.295 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 5.067851e-01 0.295 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.067851e-01 0.295 0 0
Type II Na+/Pi cotransporters R-HSA-427589 5.067851e-01 0.295 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.067851e-01 0.295 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.067851e-01 0.295 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.067851e-01 0.295 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.067851e-01 0.295 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.067851e-01 0.295 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.117703e-01 0.291 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.166028e-01 0.287 0 0
Signaling by NOTCH2 R-HSA-1980145 5.210159e-01 0.283 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.249085e-01 0.280 0 0
Pyroptosis R-HSA-5620971 5.249085e-01 0.280 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.299600e-01 0.276 0 0
G alpha (z) signalling events R-HSA-418597 5.319260e-01 0.274 0 0
Activation of SMO R-HSA-5635838 5.370323e-01 0.270 0 0
Translation of Structural Proteins R-HSA-9683701 5.393676e-01 0.268 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.442312e-01 0.264 0 0
PERK regulates gene expression R-HSA-381042 5.442312e-01 0.264 0 0
Leishmania phagocytosis R-HSA-9664417 5.449073e-01 0.264 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.449073e-01 0.264 0 0
Parasite infection R-HSA-9664407 5.449073e-01 0.264 0 0
Binding and entry of HIV virion R-HSA-173107 5.483035e-01 0.261 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.483035e-01 0.261 0 0
2-LTR circle formation R-HSA-164843 5.483035e-01 0.261 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.483035e-01 0.261 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.483035e-01 0.261 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.483035e-01 0.261 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.483035e-01 0.261 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.583521e-01 0.253 0 0
rRNA processing R-HSA-72312 5.644410e-01 0.248 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.669351e-01 0.246 0 0
G1/S-Specific Transcription R-HSA-69205 5.669351e-01 0.246 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.697778e-01 0.244 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.697778e-01 0.244 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.697778e-01 0.244 0 0
Disorders of Developmental Biology R-HSA-9675151 5.697778e-01 0.244 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.718145e-01 0.243 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.718145e-01 0.243 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.718145e-01 0.243 0 0
GABA synthesis R-HSA-888568 5.718145e-01 0.243 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.718145e-01 0.243 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.718145e-01 0.243 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.718145e-01 0.243 0 0
NADE modulates death signalling R-HSA-205025 5.718145e-01 0.243 0 0
Interleukin-38 signaling R-HSA-9007892 5.718145e-01 0.243 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.750616e-01 0.240 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.825710e-01 0.235 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.857907e-01 0.232 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.857907e-01 0.232 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.883315e-01 0.230 0 0
Formation of the posterior neural plate R-HSA-9832991 5.883315e-01 0.230 0 0
Synthesis of PI R-HSA-1483226 5.883315e-01 0.230 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.883315e-01 0.230 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.883315e-01 0.230 0 0
Interleukin-2 signaling R-HSA-9020558 5.883315e-01 0.230 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.010497e-01 0.221 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.010497e-01 0.221 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.010497e-01 0.221 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.010497e-01 0.221 0 0
MET promotes cell motility R-HSA-8875878 6.106148e-01 0.214 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.122097e-01 0.213 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.122097e-01 0.213 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.122218e-01 0.213 1 0
Protein localization R-HSA-9609507 6.222514e-01 0.206 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.222802e-01 0.206 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.256600e-01 0.204 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.256600e-01 0.204 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.256600e-01 0.204 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.256600e-01 0.204 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.256600e-01 0.204 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.256600e-01 0.204 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.282731e-01 0.202 0 0
G2 Phase R-HSA-68911 6.282731e-01 0.202 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.282731e-01 0.202 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.282731e-01 0.202 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.282731e-01 0.202 0 0
Defective F9 activation R-HSA-9673221 6.282731e-01 0.202 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.282731e-01 0.202 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.282731e-01 0.202 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.282731e-01 0.202 0 0
Activation of C3 and C5 R-HSA-174577 6.282731e-01 0.202 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.282731e-01 0.202 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.282731e-01 0.202 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.282731e-01 0.202 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.282731e-01 0.202 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.282731e-01 0.202 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.307848e-01 0.200 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.307848e-01 0.200 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.307848e-01 0.200 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.307848e-01 0.200 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.307848e-01 0.200 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.315107e-01 0.200 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.346444e-01 0.197 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.375592e-01 0.195 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.375592e-01 0.195 0 0
Formation of the nephric duct R-HSA-9830364 6.375592e-01 0.195 0 0
Neutrophil degranulation R-HSA-6798695 6.410511e-01 0.193 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.446747e-01 0.191 0 0
Interferon alpha/beta signaling R-HSA-909733 6.460354e-01 0.190 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.517351e-01 0.186 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.517351e-01 0.186 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.517351e-01 0.186 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.586046e-01 0.181 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.589468e-01 0.181 0 0
The NLRP3 inflammasome R-HSA-844456 6.589468e-01 0.181 0 0
Maturation of nucleoprotein R-HSA-9694631 6.589468e-01 0.181 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.589468e-01 0.181 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.603051e-01 0.180 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.603051e-01 0.180 0 0
MET activates RAS signaling R-HSA-8851805 6.603051e-01 0.180 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.603051e-01 0.180 0 0
Pervasive developmental disorders R-HSA-9005895 6.603051e-01 0.180 0 0
Disorders of Nervous System Development R-HSA-9697154 6.603051e-01 0.180 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.603051e-01 0.180 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.603051e-01 0.180 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.603051e-01 0.180 0 0
Interleukin-15 signaling R-HSA-8983432 6.603051e-01 0.180 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.618038e-01 0.179 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.618038e-01 0.179 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.618038e-01 0.179 0 0
TRP channels R-HSA-3295583 6.618038e-01 0.179 0 0
Neuronal System R-HSA-112316 6.649828e-01 0.177 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.662171e-01 0.176 0 0
Gluconeogenesis R-HSA-70263 6.765560e-01 0.170 0 0
NGF-independant TRKA activation R-HSA-187024 6.772902e-01 0.169 0 0
Plus-strand DNA synthesis R-HSA-164525 6.772902e-01 0.169 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.772902e-01 0.169 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.772902e-01 0.169 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.772902e-01 0.169 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.772902e-01 0.169 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.772902e-01 0.169 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.772902e-01 0.169 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.772902e-01 0.169 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.772902e-01 0.169 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.772902e-01 0.169 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.772902e-01 0.169 0 0
Synthesis of PS R-HSA-1483101 6.772902e-01 0.169 0 0
PDE3B signalling R-HSA-165160 6.772902e-01 0.169 0 0
Phosphorylation of Emi1 R-HSA-176417 6.772902e-01 0.169 0 0
PKB-mediated events R-HSA-109703 6.772902e-01 0.169 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.772902e-01 0.169 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.772902e-01 0.169 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.772902e-01 0.169 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.772902e-01 0.169 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.772902e-01 0.169 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.777762e-01 0.169 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.849216e-01 0.164 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.849216e-01 0.164 0 0
Cristae formation R-HSA-8949613 6.849216e-01 0.164 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.855222e-01 0.164 0 0
Protein hydroxylation R-HSA-9629569 6.855222e-01 0.164 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.855222e-01 0.164 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.855222e-01 0.164 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.868866e-01 0.163 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.900801e-01 0.161 0 0
HIV Transcription Initiation R-HSA-167161 6.900801e-01 0.161 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.900801e-01 0.161 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.923252e-01 0.160 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.923252e-01 0.160 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.923252e-01 0.160 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.923252e-01 0.160 0 0
Platelet homeostasis R-HSA-418346 6.935405e-01 0.159 0 0
Translation R-HSA-72766 6.939706e-01 0.159 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.986530e-01 0.156 0 0
Ca2+ pathway R-HSA-4086398 7.067378e-01 0.151 0 0
HIV elongation arrest and recovery R-HSA-167287 7.069021e-01 0.151 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.069021e-01 0.151 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.069021e-01 0.151 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.069021e-01 0.151 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.105165e-01 0.148 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.105165e-01 0.148 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.106347e-01 0.148 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.111196e-01 0.148 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.136621e-01 0.147 0 0
Stimuli-sensing channels R-HSA-2672351 7.169150e-01 0.145 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.198462e-01 0.143 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.198462e-01 0.143 0 0
Uncoating of the HIV Virion R-HSA-162585 7.198462e-01 0.143 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.198462e-01 0.143 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.198462e-01 0.143 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.198462e-01 0.143 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.198462e-01 0.143 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.198462e-01 0.143 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.198462e-01 0.143 0 0
HDL clearance R-HSA-8964011 7.198462e-01 0.143 0 0
Neurofascin interactions R-HSA-447043 7.198462e-01 0.143 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.218102e-01 0.142 0 0
Malate-aspartate shuttle R-HSA-9856872 7.218102e-01 0.142 0 0
Zinc transporters R-HSA-435354 7.218102e-01 0.142 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.255266e-01 0.139 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.255616e-01 0.139 0 0
RNA Polymerase III Transcription R-HSA-74158 7.255616e-01 0.139 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.269094e-01 0.139 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.339514e-01 0.134 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.339514e-01 0.134 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.433282e-01 0.129 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.474598e-01 0.126 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.474598e-01 0.126 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.488717e-01 0.126 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.488717e-01 0.126 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.488717e-01 0.126 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.488717e-01 0.126 0 0
Biotin transport and metabolism R-HSA-196780 7.488717e-01 0.126 0 0
Formation of the anterior neural plate R-HSA-9823739 7.488717e-01 0.126 0 0
Interferon gamma signaling R-HSA-877300 7.551319e-01 0.122 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.558614e-01 0.122 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.558614e-01 0.122 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.558614e-01 0.122 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.558614e-01 0.122 0 0
LDL clearance R-HSA-8964038 7.558614e-01 0.122 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.558614e-01 0.122 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.567925e-01 0.121 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.567925e-01 0.121 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.567925e-01 0.121 0 0
Recycling of eIF2:GDP R-HSA-72731 7.567925e-01 0.121 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.567925e-01 0.121 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.567925e-01 0.121 0 0
PTK6 Expression R-HSA-8849473 7.567925e-01 0.121 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.567925e-01 0.121 0 0
Activation of TRKA receptors R-HSA-187015 7.567925e-01 0.121 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.567925e-01 0.121 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.567925e-01 0.121 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.567925e-01 0.121 0 0
VLDL clearance R-HSA-8964046 7.567925e-01 0.121 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.567925e-01 0.121 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.567925e-01 0.121 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.567925e-01 0.121 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.567925e-01 0.121 0 0
Aquaporin-mediated transport R-HSA-445717 7.572223e-01 0.121 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.580310e-01 0.120 0 0
Adipogenesis R-HSA-9843745 7.596089e-01 0.119 0 0
Ion channel transport R-HSA-983712 7.609809e-01 0.119 0 0
IRE1alpha activates chaperones R-HSA-381070 7.633186e-01 0.117 0 0
Cargo concentration in the ER R-HSA-5694530 7.660626e-01 0.116 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.731850e-01 0.112 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.736361e-01 0.111 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.736361e-01 0.111 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.736361e-01 0.111 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.736361e-01 0.111 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.736361e-01 0.111 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.743690e-01 0.111 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.762913e-01 0.110 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.762913e-01 0.110 0 0
Formation of the ureteric bud R-HSA-9830674 7.762913e-01 0.110 0 0
Carnitine shuttle R-HSA-200425 7.762913e-01 0.110 0 0
Interleukin-20 family signaling R-HSA-8854691 7.762913e-01 0.110 0 0
Innate Immune System R-HSA-168249 7.810168e-01 0.107 1 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.839845e-01 0.106 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.839845e-01 0.106 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.876167e-01 0.104 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.888682e-01 0.103 0 0
Minus-strand DNA synthesis R-HSA-164516 7.888682e-01 0.103 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.888682e-01 0.103 0 0
Interleukin-9 signaling R-HSA-8985947 7.888682e-01 0.103 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.888682e-01 0.103 0 0
Alpha-defensins R-HSA-1462054 7.888682e-01 0.103 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.948257e-01 0.100 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.952940e-01 0.099 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.952940e-01 0.099 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.952940e-01 0.099 0 0
Interleukin-6 family signaling R-HSA-6783589 7.952940e-01 0.099 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.952940e-01 0.099 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.962385e-01 0.099 0 0
Synthesis of PG R-HSA-1483148 7.962385e-01 0.099 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.011891e-01 0.096 0 0
Intraflagellar transport R-HSA-5620924 8.013373e-01 0.096 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.129286e-01 0.090 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.129286e-01 0.090 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.154558e-01 0.089 0 0
Interleukin-21 signaling R-HSA-9020958 8.167151e-01 0.088 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.167151e-01 0.088 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.167151e-01 0.088 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.167151e-01 0.088 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.167151e-01 0.088 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.167151e-01 0.088 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.167151e-01 0.088 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.167151e-01 0.088 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.168183e-01 0.088 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.168183e-01 0.088 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.168183e-01 0.088 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.197948e-01 0.086 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.220776e-01 0.085 0 0
Rab regulation of trafficking R-HSA-9007101 8.248308e-01 0.084 0 0
Cardiac conduction R-HSA-5576891 8.264061e-01 0.083 0 0
MET activates PTK2 signaling R-HSA-8874081 8.292581e-01 0.081 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.292581e-01 0.081 0 0
Kidney development R-HSA-9830369 8.297119e-01 0.081 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.298903e-01 0.081 0 0
Signal amplification R-HSA-392518 8.298903e-01 0.081 0 0
Neddylation R-HSA-8951664 8.312640e-01 0.080 0 0
RSV-host interactions R-HSA-9833110 8.326967e-01 0.080 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.355158e-01 0.078 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.355158e-01 0.078 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.355158e-01 0.078 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.355158e-01 0.078 0 0
Mismatch Repair R-HSA-5358508 8.355158e-01 0.078 0 0
Nephron development R-HSA-9831926 8.355158e-01 0.078 0 0
Transcription of the HIV genome R-HSA-167172 8.399681e-01 0.076 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.408907e-01 0.075 0 0
Serotonin receptors R-HSA-390666 8.408907e-01 0.075 0 0
DNA replication initiation R-HSA-68952 8.408907e-01 0.075 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.408907e-01 0.075 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.408907e-01 0.075 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.408907e-01 0.075 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.409233e-01 0.075 0 0
Regulation of insulin secretion R-HSA-422356 8.416125e-01 0.075 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.443486e-01 0.073 0 0
tRNA processing R-HSA-72306 8.454752e-01 0.073 0 0
Translation of Structural Proteins R-HSA-9694635 8.465738e-01 0.072 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.524694e-01 0.069 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.524694e-01 0.069 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.524694e-01 0.069 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.524694e-01 0.069 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.524694e-01 0.069 0 0
Other interleukin signaling R-HSA-449836 8.524694e-01 0.069 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.559427e-01 0.068 0 0
Triglyceride catabolism R-HSA-163560 8.559427e-01 0.068 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.582675e-01 0.066 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.582675e-01 0.066 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.582675e-01 0.066 0 0
Pyrimidine salvage R-HSA-73614 8.582675e-01 0.066 0 0
Inflammasomes R-HSA-622312 8.582675e-01 0.066 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.592425e-01 0.066 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.618786e-01 0.065 0 0
LGI-ADAM interactions R-HSA-5682910 8.618786e-01 0.065 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.618786e-01 0.065 0 0
vRNP Assembly R-HSA-192905 8.618786e-01 0.065 0 0
vRNA Synthesis R-HSA-192814 8.618786e-01 0.065 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.618786e-01 0.065 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.618786e-01 0.065 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.618786e-01 0.065 0 0
Transport of RCbl within the body R-HSA-9758890 8.618786e-01 0.065 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.618786e-01 0.065 0 0
Mitochondrial protein import R-HSA-1268020 8.635765e-01 0.064 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.641500e-01 0.063 0 0
mRNA Capping R-HSA-72086 8.710828e-01 0.060 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.726131e-01 0.059 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.726131e-01 0.059 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.785174e-01 0.056 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.800991e-01 0.055 0 0
Plasmalogen biosynthesis R-HSA-75896 8.800991e-01 0.055 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.800991e-01 0.055 0 0
Sodium/Calcium exchangers R-HSA-425561 8.800991e-01 0.055 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.800991e-01 0.055 0 0
Lagging Strand Synthesis R-HSA-69186 8.816782e-01 0.055 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.816782e-01 0.055 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.816782e-01 0.055 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.828620e-01 0.054 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.886077e-01 0.051 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.936717e-01 0.049 0 0
Serine metabolism R-HSA-977347 8.941862e-01 0.049 0 0
Ribavirin ADME R-HSA-9755088 8.941862e-01 0.049 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.944226e-01 0.048 0 0
Metal ion SLC transporters R-HSA-425410 8.958063e-01 0.048 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.959170e-01 0.048 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.959170e-01 0.048 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.959170e-01 0.048 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.959170e-01 0.048 0 0
Leading Strand Synthesis R-HSA-69109 8.959170e-01 0.048 0 0
Polymerase switching R-HSA-69091 8.959170e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.959170e-01 0.048 0 0
OAS antiviral response R-HSA-8983711 8.959170e-01 0.048 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.979570e-01 0.047 0 0
HIV Transcription Elongation R-HSA-167169 8.979570e-01 0.047 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.979570e-01 0.047 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.986753e-01 0.046 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.054543e-01 0.043 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.054543e-01 0.043 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.096488e-01 0.041 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.096488e-01 0.041 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.096488e-01 0.041 0 0
Processing of SMDT1 R-HSA-8949664 9.096488e-01 0.041 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.096488e-01 0.041 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.096488e-01 0.041 0 0
Triglyceride metabolism R-HSA-8979227 9.104585e-01 0.041 0 0
Azathioprine ADME R-HSA-9748787 9.115339e-01 0.040 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.116766e-01 0.040 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.146013e-01 0.039 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.155919e-01 0.038 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.171419e-01 0.038 0 0
Removal of the Flap Intermediate R-HSA-69166 9.215697e-01 0.035 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.215697e-01 0.035 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.215697e-01 0.035 0 0
Hydrolysis of LPC R-HSA-1483115 9.215697e-01 0.035 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.215697e-01 0.035 0 0
Physiological factors R-HSA-5578768 9.215697e-01 0.035 0 0
Prolactin receptor signaling R-HSA-1170546 9.215697e-01 0.035 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.215697e-01 0.035 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.215697e-01 0.035 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.215697e-01 0.035 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.215697e-01 0.035 0 0
Pyruvate metabolism R-HSA-70268 9.241499e-01 0.034 0 0
eNOS activation R-HSA-203615 9.284782e-01 0.032 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.284782e-01 0.032 0 0
Infectious disease R-HSA-5663205 9.293540e-01 0.032 1 0
Amino acids regulate mTORC1 R-HSA-9639288 9.312164e-01 0.031 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.319184e-01 0.031 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.319184e-01 0.031 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.319184e-01 0.031 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.319184e-01 0.031 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 9.319184e-01 0.031 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.319184e-01 0.031 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.319184e-01 0.031 0 0
Other semaphorin interactions R-HSA-416700 9.319184e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.319184e-01 0.031 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.328766e-01 0.030 0 0
Laminin interactions R-HSA-3000157 9.328766e-01 0.030 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.328766e-01 0.030 0 0
Hyaluronan degradation R-HSA-2160916 9.328766e-01 0.030 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.328766e-01 0.030 0 0
Surfactant metabolism R-HSA-5683826 9.350373e-01 0.029 0 0
Amine ligand-binding receptors R-HSA-375280 9.350373e-01 0.029 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.356754e-01 0.029 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.356754e-01 0.029 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.402063e-01 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.402063e-01 0.027 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.409021e-01 0.026 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.409021e-01 0.026 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.409021e-01 0.026 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.409021e-01 0.026 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.409021e-01 0.026 0 0
Differentiation of T cells R-HSA-9945266 9.409021e-01 0.026 0 0
Attachment and Entry R-HSA-9678110 9.409021e-01 0.026 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.452614e-01 0.024 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.466713e-01 0.024 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.467709e-01 0.024 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.467709e-01 0.024 0 0
Triglyceride biosynthesis R-HSA-75109 9.467709e-01 0.024 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.467709e-01 0.024 0 0
Iron uptake and transport R-HSA-917937 9.472813e-01 0.024 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.473394e-01 0.023 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.487008e-01 0.023 0 0
Fibronectin matrix formation R-HSA-1566977 9.487008e-01 0.023 0 0
Heme assimilation R-HSA-9927020 9.487008e-01 0.023 0 0
Galactose catabolism R-HSA-70370 9.487008e-01 0.023 0 0
Coenzyme A biosynthesis R-HSA-196783 9.487008e-01 0.023 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.487008e-01 0.023 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.487008e-01 0.023 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.500618e-01 0.022 0 0
Elastic fibre formation R-HSA-1566948 9.525195e-01 0.021 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.525195e-01 0.021 0 0
Telomere Extension By Telomerase R-HSA-171319 9.526448e-01 0.021 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.539584e-01 0.020 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.554707e-01 0.020 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.554707e-01 0.020 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.554707e-01 0.020 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.554707e-01 0.020 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.554707e-01 0.020 0 0
Pentose phosphate pathway R-HSA-71336 9.572202e-01 0.019 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.572202e-01 0.019 0 0
Integrin cell surface interactions R-HSA-216083 9.583706e-01 0.018 0 0
Extension of Telomeres R-HSA-180786 9.592571e-01 0.018 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.613476e-01 0.017 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.613476e-01 0.017 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.613476e-01 0.017 0 0
SLC transporter disorders R-HSA-5619102 9.620556e-01 0.017 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.625860e-01 0.017 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.664492e-01 0.015 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.664492e-01 0.015 0 0
Pyrimidine biosynthesis R-HSA-500753 9.664492e-01 0.015 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.664492e-01 0.015 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.664492e-01 0.015 0 0
Diseases of hemostasis R-HSA-9671793 9.664492e-01 0.015 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.667719e-01 0.015 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.688348e-01 0.014 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.688348e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.708776e-01 0.013 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.708776e-01 0.013 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.708776e-01 0.013 0 0
Pregnenolone biosynthesis R-HSA-196108 9.708776e-01 0.013 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.716708e-01 0.012 0 0
Activation of GABAB receptors R-HSA-991365 9.719929e-01 0.012 0 0
GABA B receptor activation R-HSA-977444 9.719929e-01 0.012 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.719929e-01 0.012 0 0
Disease R-HSA-1643685 9.732819e-01 0.012 1 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.733924e-01 0.012 0 0
Recycling of bile acids and salts R-HSA-159418 9.738318e-01 0.012 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.747218e-01 0.011 0 0
G-protein activation R-HSA-202040 9.747218e-01 0.011 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.747218e-01 0.011 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.747218e-01 0.011 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.747218e-01 0.011 0 0
Phenylalanine metabolism R-HSA-8964208 9.747218e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.747218e-01 0.011 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.767945e-01 0.010 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.767945e-01 0.010 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.774215e-01 0.010 0 0
Paracetamol ADME R-HSA-9753281 9.774783e-01 0.010 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.780587e-01 0.010 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.780587e-01 0.010 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.780587e-01 0.010 0 0
Attachment and Entry R-HSA-9694614 9.780587e-01 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.785417e-01 0.009 0 0
Mitochondrial protein degradation R-HSA-9837999 9.789197e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.794312e-01 0.009 0 0
RA biosynthesis pathway R-HSA-5365859 9.794312e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.799747e-01 0.009 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.809553e-01 0.008 0 0
Ethanol oxidation R-HSA-71384 9.809553e-01 0.008 0 0
Dectin-2 family R-HSA-5621480 9.815755e-01 0.008 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.817764e-01 0.008 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.818385e-01 0.008 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.818385e-01 0.008 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.818385e-01 0.008 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.827753e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.834022e-01 0.007 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.834697e-01 0.007 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.834697e-01 0.007 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.834697e-01 0.007 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.834697e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.834697e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.837244e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.838610e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.838610e-01 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 9.853137e-01 0.006 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.856522e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.856522e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.856522e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.856522e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.857130e-01 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.863140e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.864229e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.864229e-01 0.006 0 0
ECM proteoglycans R-HSA-3000178 9.866597e-01 0.006 0 0
G protein gated Potassium channels R-HSA-1296059 9.875467e-01 0.005 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.875467e-01 0.005 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.875467e-01 0.005 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.875467e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.875467e-01 0.005 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.881847e-01 0.005 0 0
Sphingolipid catabolism R-HSA-9845614 9.891911e-01 0.005 0 0
The phototransduction cascade R-HSA-2514856 9.895545e-01 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.901114e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.906184e-01 0.004 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.906184e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.906184e-01 0.004 0 0
Insulin processing R-HSA-264876 9.906184e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.912591e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.912591e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.916550e-01 0.004 0 0
Intra-Golgi traffic R-HSA-6811438 9.922762e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.929328e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.929328e-01 0.003 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.929328e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.929328e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.929328e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.930792e-01 0.003 0 0
G alpha (q) signalling events R-HSA-416476 9.932415e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.938662e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.940020e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.942309e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.945436e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.946812e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.947005e-01 0.002 0 0
DAG1 glycosylations R-HSA-8931838 9.953796e-01 0.002 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.953796e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.957867e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.959127e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.959899e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.960800e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.962453e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.965197e-01 0.002 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.965197e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.965197e-01 0.002 0 0
Heme degradation R-HSA-189483 9.965197e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.966551e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.966551e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.969795e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.971603e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.973094e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.973786e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.973786e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.973786e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.973786e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.977947e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.980256e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.980256e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.980256e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.982140e-01 0.001 0 0
Purine salvage R-HSA-74217 9.982865e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.985129e-01 0.001 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.987095e-01 0.001 0 0
Diseases of Immune System R-HSA-5260271 9.987095e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.988352e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.988366e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.989541e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.989548e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.989656e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.990153e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.990281e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.991565e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.992051e-01 0.000 0 0
Defensins R-HSA-1461973 9.992680e-01 0.000 0 0
Methylation R-HSA-156581 9.993648e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.995826e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.996007e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996066e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.996874e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997170e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997170e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997170e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.997209e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997288e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998090e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998318e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.998462e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998532e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998695e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998842e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998863e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999316e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999327e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999327e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.999344e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999344e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999431e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999472e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999507e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999571e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999660e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999667e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999719e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999757e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999789e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999789e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999841e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999862e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999862e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999862e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999881e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999896e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999922e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999946e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999949e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999967e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999972e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999986e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999988e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999992e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999992e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999994e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999994e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999995e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999998e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 1 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways