PAK5

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O15013 S1232 Sugiyama ARHGEF10 KIAA0294 VKFIVLATALHEKDKDKsRDsLAPGPEPQDEDQKDALPSGG
O15357 S1176 Sugiyama INPPL1 SHIP2 RGLPsDyGRPLsFPPPRIREsIQEDLAEEAPCLQGGRASGL
O43159 S309 Sugiyama RRP8 KIAA0409 NML hucep-1 KKWPLQPVDRIARDLRQRPAsLVVADFGCGDCRLASSIRNP
O43847 S94 Sugiyama NRDC NRD1 ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O95831 T281 PSP AIFM1 AIF PDCD8 GGtPRsLsAIDRAGAEVKSRtTLFRKIGDFRsLEKISREVK
O96013 S181 Sugiyama PAK4 KIAA1142 KSSREGsGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAA
O96013 S41 Sugiyama PAK4 KIAA1142 VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
O96013 T187 Sugiyama PAK4 KIAA1142 sGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAAGRPFNt
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06737 S430 Sugiyama PYGL KHLDRIVALFPKDVDRLRRMsLIEEEGSKRINMAHLCIVGS
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07602 S29 Sugiyama PSAP GLBA SAP1 SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07737 S58 Sugiyama PFN1 KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15923 S39 PSP TCF3 BHLHB21 E2A ITF1 LLDFSMMFPLPVTNGKGRPAsLAGAQFGGsGLEDRPssGSW
P15976 S161 PSP GATA1 ERYF1 GF1 LSPDLLTLGPALPSSLPVPNsAYGGPDFSsTFFsPtGsPLN
P15976 S187 PSP GATA1 ERYF1 GF1 DFSsTFFsPtGsPLNSAAYSsPKLRGTLPLPPCEARECVNC
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17844 T69 PSP DDX5 G17P1 HELR HLR1 DELPKFEKNFyQEHPDLARRtAQEVETYRRSKEITVRGHNC
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P23142 T250 Sugiyama FBLN1 PP213 GESCINTVGSFRCQRDssCGtGYELTEDNSCKDIDECESGI
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789 T9 Sugiyama PSMA4 HC9 PSC9 ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P27448 S42 Sugiyama MARK3 CTAK1 EMK2 GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27448 S45 Sugiyama MARK3 CTAK1 EMK2 RQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTIGKG
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30044 S182 Sugiyama PRDX5 ACR1 SBBI10 DLLLDDsLVsIFGNRRLKRFsMVVQDGIVKALNVEPDGTGL
P30048 S199 Sugiyama PRDX3 AOP1 SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43121 S93 Sugiyama MCAM MUC18 IFRVRQGQGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERI
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46940 S482 Sugiyama IQGAP1 KIAA0051 LINRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELM
P46940 T484 Sugiyama IQGAP1 KIAA0051 NRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELMKL
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48643 S51 Sugiyama CCT5 CCTE KIAA0098 LEALKSHIMAAKAVANtMRtsLGPNGLDKMMVDKDGDVtVT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P50395 S427 Sugiyama GDI2 RABGDIB ttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED__
P51570 S230 Sugiyama GALK1 GALK LVPLSDPKLAVLITNSNVRHsLASSEYPVRRRQCEEVARAL
P51957 S377 Sugiyama NEK4 STK2 TELATISSVNIDILPAKGRDsVsDGFVQENQPRYLDASNEL
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62873 S147 Sugiyama GNB1 KTREGNVRVSRELAGHTGyLsCCRFLDDNQIVTSSGDTTCA
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q05519 S287 PSP SRSF11 SFRS11 RRSRSRSRRRSHSKSRSRRRsKSPRRRRSHSRERGRRSRST
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q12789 S1865 Sugiyama GTF3C1 sPPEGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKR
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5TAX3 S1383 Sugiyama TUT4 KIAA0191 ZCCHC11 GDAGHVRRECPEVKLARQRNssVAAAQLVRNLVNAQQVAGS
Q6IBS0 S139 Sugiyama TWF2 PTK9L MSTP011 DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q6IBS0 S140 Sugiyama TWF2 PTK9L MSTP011 ELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRIN
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q76FK4 S296 Sugiyama NOL8 C9orf34 NOP132 QKLKNLPFKTSGLETAKKRNsIsDDDtDsEDELRMMIAKEE
Q8N584 S472 Sugiyama TTC39C C18orf17 EVLYLWKALPNCSFPNLQRMsQACHEVDDSSVVGLKYLLLG
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TCS8 S767 Sugiyama PNPT1 PNPASE LSRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ____
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0 S720 Sugiyama PARD3 PAR3 PAR3A ELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIMG
Q8WXE0 S403 Sugiyama CASKIN2 KIAA1139 tysQLPRVGLsPDsPAGDRNsVGsEGsVGsIRSAGSGQSSE
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96D15 S117 Sugiyama RCN3 UNQ239/PRO272 VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96EP5 S195 Sugiyama DAZAP1 FHDIMGKKVEVKRAEPRDsKsQAPGQPGAsQWGsRVVPNAA
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BTC0 S1026 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 VMVPKSILAKPsssPDPRYLsVPPsPNIstsEsRsPPEGDt
Q9C0C2 S893 Sugiyama TNKS1BP1 KIAA1741 TAB182 LGtyssRDVsLGDWEFGKRDsLGAyAsQDANEQGQDLGKRD
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HA77 T546 Sugiyama CARS2 OK/SW-cl.10 CDTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG__
Q9HCN4 S301 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NQU5 S560 Sugiyama PAK6 PAK5 VKLSDFGFCAQISKDVPKRKsLVGtPyWMAPEVISRSLYAT
Q9P286 S573 iPTMNet|PSP PAK5 KIAA1264 PAK7 LRALSYLHNQGVIHRDIKSDsILLTSDGRIKLSDFGFCAQV
Q9UBP0 S92 Sugiyama SPAST ADPSP FSP2 KIAA1083 SPG4 GLLFVWLCQRFSRALMAAKRssGAAPAPASASAPAPVPGGE
Q9UBU9 S431 Sugiyama NXF1 TAP HDGACCSLSIPFIPQNPARSsLAEyFKDSRNVKKLKDPTLR
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.772036e-10 9.423 0 0
HSF1-dependent transactivation R-HSA-3371571 1.089828e-08 7.963 0 0
Signal Transduction R-HSA-162582 7.284929e-08 7.138 1 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.007944e-07 6.997 0 0
Attenuation phase R-HSA-3371568 1.641650e-07 6.785 0 0
Cell Cycle, Mitotic R-HSA-69278 1.534514e-07 6.814 0 0
Cellular response to heat stress R-HSA-3371556 2.070839e-07 6.684 0 0
Cell Cycle Checkpoints R-HSA-69620 2.320603e-07 6.634 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.446038e-07 6.612 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.002677e-07 6.222 0 0
Chromatin modifying enzymes R-HSA-3247509 1.800373e-06 5.745 0 0
DNA methylation R-HSA-5334118 2.462037e-06 5.609 0 0
HSF1 activation R-HSA-3371511 2.526002e-06 5.598 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.307279e-06 5.481 0 0
Meiotic synapsis R-HSA-1221632 3.258358e-06 5.487 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.179519e-06 5.498 0 0
M Phase R-HSA-68886 4.448947e-06 5.352 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.394351e-06 5.268 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.613320e-06 5.251 0 0
Chromatin organization R-HSA-4839726 5.138093e-06 5.289 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.997339e-06 5.301 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.673178e-06 5.246 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.718443e-06 5.060 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.405087e-06 5.027 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.254464e-05 4.902 0 0
Diseases of programmed cell death R-HSA-9645723 1.545794e-05 4.811 0 0
HDACs deacetylate histones R-HSA-3214815 1.681043e-05 4.774 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.006120e-05 4.698 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.498286e-05 4.602 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.924878e-05 4.534 0 0
Regulation of TP53 Activity R-HSA-5633007 2.973561e-05 4.527 0 0
Death Receptor Signaling R-HSA-73887 2.881610e-05 4.540 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.160869e-05 4.500 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.389804e-05 4.470 0 0
Mitotic Prophase R-HSA-68875 3.514657e-05 4.454 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.977494e-05 4.400 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.350356e-05 4.361 0 0
Nucleosome assembly R-HSA-774815 4.350356e-05 4.361 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.768901e-05 4.322 0 0
Meiosis R-HSA-1500620 4.843635e-05 4.315 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.123724e-05 4.290 0 0
Interleukin-37 signaling R-HSA-9008059 5.300653e-05 4.276 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.290850e-05 4.201 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.342912e-05 4.198 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.480129e-05 4.188 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.692784e-05 4.174 0 0
Packaging Of Telomere Ends R-HSA-171306 7.698547e-05 4.114 0 0
Nervous system development R-HSA-9675108 9.795187e-05 4.009 1 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.233245e-04 3.909 0 0
Axon guidance R-HSA-422475 1.248867e-04 3.903 1 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.262380e-04 3.899 0 0
NRAGE signals death through JNK R-HSA-193648 1.717798e-04 3.765 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.933839e-04 3.714 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.086952e-04 3.680 0 0
G alpha (12/13) signalling events R-HSA-416482 2.184838e-04 3.661 0 0
Defective pyroptosis R-HSA-9710421 2.473964e-04 3.607 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.957046e-04 3.529 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.066370e-04 3.513 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.015518e-04 3.521 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.305126e-04 3.481 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.226423e-04 3.491 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.195796e-04 3.495 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.544631e-04 3.450 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.011815e-04 3.397 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.087620e-04 3.389 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.139872e-04 3.383 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.326864e-04 3.364 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.433307e-04 3.353 0 0
Post NMDA receptor activation events R-HSA-438064 4.462087e-04 3.350 0 0
G2/M Checkpoints R-HSA-69481 4.562410e-04 3.341 0 0
Meiotic recombination R-HSA-912446 4.657641e-04 3.332 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.123119e-04 3.290 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.186785e-04 3.285 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.260907e-04 3.279 0 0
HDMs demethylate histones R-HSA-3214842 5.433212e-04 3.265 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.552813e-04 3.255 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.598147e-04 3.252 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.706410e-04 3.244 0 0
Depyrimidination R-HSA-73928 5.706410e-04 3.244 0 0
Gene expression (Transcription) R-HSA-74160 5.713494e-04 3.243 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.752399e-04 3.171 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.752399e-04 3.171 0 0
Reproduction R-HSA-1474165 7.232324e-04 3.141 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.621965e-04 3.064 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.394207e-04 3.027 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.623474e-04 3.017 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.934908e-04 3.003 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.934908e-04 3.003 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.001373e-03 2.999 0 0
Mitotic Prometaphase R-HSA-68877 1.097064e-03 2.960 0 0
RNA Polymerase II Transcription R-HSA-73857 1.071705e-03 2.970 0 0
Cellular Senescence R-HSA-2559583 1.062457e-03 2.974 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.111061e-03 2.954 0 0
DNA Double Strand Break Response R-HSA-5693606 1.195218e-03 2.923 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.286363e-03 2.891 0 0
Signaling by WNT R-HSA-195721 1.258417e-03 2.900 0 0
Apoptotic execution phase R-HSA-75153 1.256069e-03 2.901 0 0
Cleavage of the damaged purine R-HSA-110331 1.287318e-03 2.890 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.427538e-03 2.845 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.442616e-03 2.841 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.567531e-03 2.805 0 0
Depurination R-HSA-73927 1.580360e-03 2.801 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.597261e-03 2.797 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.964376e-03 2.707 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.471448e-03 2.607 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.552515e-03 2.593 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.703453e-03 2.568 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.873786e-03 2.542 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.810042e-03 2.551 0 0
Activation of RAC1 R-HSA-428540 2.745178e-03 2.561 1 1
FLT3 Signaling R-HSA-9607240 2.810042e-03 2.551 0 0
RET signaling R-HSA-8853659 2.897307e-03 2.538 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.993773e-03 2.524 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.157537e-03 2.501 0 0
Rap1 signalling R-HSA-392517 3.157537e-03 2.501 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.418665e-03 2.466 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.418665e-03 2.466 0 0
mRNA 3'-end processing R-HSA-72187 3.499543e-03 2.456 0 0
Generic Transcription Pathway R-HSA-212436 3.506732e-03 2.455 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.588278e-03 2.445 0 0
Recycling pathway of L1 R-HSA-437239 3.758278e-03 2.425 0 0
Signaling by ROBO receptors R-HSA-376176 4.197977e-03 2.377 1 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.198453e-03 2.377 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.229999e-03 2.374 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.304309e-03 2.366 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.546901e-03 2.342 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.747382e-03 2.324 0 0
ESR-mediated signaling R-HSA-8939211 4.758859e-03 2.322 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.201269e-03 2.284 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.972473e-03 2.303 0 0
Ub-specific processing proteases R-HSA-5689880 5.202501e-03 2.284 0 0
G2/M Transition R-HSA-69275 5.164436e-03 2.287 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.367812e-03 2.270 0 0
HATs acetylate histones R-HSA-3214847 5.396349e-03 2.268 0 0
RNA Polymerase I Transcription R-HSA-73864 5.423435e-03 2.266 0 0
Chromosome Maintenance R-HSA-73886 5.515702e-03 2.258 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.683368e-03 2.245 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.748919e-03 2.240 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.968211e-03 2.224 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.006336e-03 2.221 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.620528e-03 2.179 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.620528e-03 2.179 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.620528e-03 2.179 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.646029e-03 2.177 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.644070e-03 2.178 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.646029e-03 2.177 0 0
Gene Silencing by RNA R-HSA-211000 7.202969e-03 2.142 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.277703e-03 2.138 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.496307e-03 2.125 0 0
Homology Directed Repair R-HSA-5693538 7.510671e-03 2.124 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.796922e-03 2.108 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.115255e-03 2.091 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.138618e-03 2.089 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.144553e-03 2.089 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.144553e-03 2.089 0 0
Notch-HLH transcription pathway R-HSA-350054 8.301333e-03 2.081 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.301333e-03 2.081 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.632432e-03 2.064 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.131778e-03 2.039 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.374086e-03 2.028 0 0
Apoptosis R-HSA-109581 9.428750e-03 2.026 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.502776e-03 2.022 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.018609e-02 1.992 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.025240e-02 1.989 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.075157e-02 1.969 0 0
Kinesins R-HSA-983189 1.079172e-02 1.967 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.128701e-02 1.947 0 0
DARPP-32 events R-HSA-180024 1.200154e-02 1.921 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.171445e-02 1.931 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.184100e-02 1.927 0 0
Mitotic Anaphase R-HSA-68882 1.110846e-02 1.954 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.116794e-02 1.952 0 0
Neuronal System R-HSA-112316 1.095096e-02 1.961 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.189585e-02 1.925 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.169955e-02 1.932 0 0
Cell junction organization R-HSA-446728 1.117282e-02 1.952 0 0
L1CAM interactions R-HSA-373760 1.113311e-02 1.953 0 0
Rab regulation of trafficking R-HSA-9007101 1.215017e-02 1.915 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.224379e-02 1.912 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.226074e-02 1.911 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.232341e-02 1.909 0 0
Formation of definitive endoderm R-HSA-9823730 1.271757e-02 1.896 0 0
Programmed Cell Death R-HSA-5357801 1.313952e-02 1.881 0 0
Cell-Cell communication R-HSA-1500931 1.317299e-02 1.880 0 0
RAF activation R-HSA-5673000 1.331639e-02 1.876 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.336165e-02 1.874 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.500980e-02 1.824 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.500980e-02 1.824 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.500980e-02 1.824 0 0
Centrosome maturation R-HSA-380287 1.525060e-02 1.817 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.733279e-02 1.761 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.706610e-02 1.768 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.706610e-02 1.768 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.706610e-02 1.768 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.552530e-02 1.809 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.552530e-02 1.809 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.733149e-02 1.761 0 0
Signaling by RAS mutants R-HSA-6802949 1.706610e-02 1.768 0 0
Neurexins and neuroligins R-HSA-6794361 1.737246e-02 1.760 0 0
Signaling by NOTCH1 R-HSA-1980143 1.695568e-02 1.771 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.784756e-02 1.748 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.899590e-02 1.721 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.899590e-02 1.721 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.915631e-02 1.718 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.915631e-02 1.718 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.023751e-02 1.694 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.080633e-02 1.682 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.107121e-02 1.676 0 0
Deubiquitination R-HSA-5688426 2.158692e-02 1.666 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.161608e-02 1.665 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.312448e-02 1.636 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.325936e-02 1.633 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.325936e-02 1.633 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.325936e-02 1.633 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.418064e-02 1.617 0 0
Regulation of KIT signaling R-HSA-1433559 2.430033e-02 1.614 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.549208e-02 1.594 0 0
Signaling by SCF-KIT R-HSA-1433557 2.481547e-02 1.605 0 0
Telomere Maintenance R-HSA-157579 2.698985e-02 1.569 0 0
TNF signaling R-HSA-75893 2.788522e-02 1.555 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.679066e-02 1.572 0 0
Cardiac conduction R-HSA-5576891 2.565547e-02 1.591 0 0
Signaling by VEGF R-HSA-194138 2.506007e-02 1.601 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.703096e-02 1.568 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.679815e-02 1.572 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.788522e-02 1.555 0 0
Amyloid fiber formation R-HSA-977225 2.779447e-02 1.556 0 0
RMTs methylate histone arginines R-HSA-3214858 2.817122e-02 1.550 0 0
Netrin-1 signaling R-HSA-373752 2.817122e-02 1.550 0 0
Adherens junctions interactions R-HSA-418990 2.850661e-02 1.545 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.044398e-02 1.516 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.044398e-02 1.516 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.044732e-02 1.516 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.112138e-02 1.507 0 0
DAG and IP3 signaling R-HSA-1489509 3.184403e-02 1.497 0 0
FOXO-mediated transcription R-HSA-9614085 3.184614e-02 1.497 0 0
Neurodegenerative Diseases R-HSA-8863678 3.272594e-02 1.485 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.272594e-02 1.485 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.371782e-02 1.472 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.467167e-02 1.460 0 0
Activation of BH3-only proteins R-HSA-114452 3.467167e-02 1.460 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.502108e-02 1.456 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.511744e-02 1.454 0 0
Regulation of PTEN localization R-HSA-8948747 3.511744e-02 1.454 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.511744e-02 1.454 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.567141e-02 1.448 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.584782e-02 1.446 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.599230e-02 1.444 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 3.780511e-02 1.422 0 0
TGFBR3 expression R-HSA-9839394 3.841740e-02 1.415 0 0
Trafficking of AMPA receptors R-HSA-399719 4.002070e-02 1.398 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.790967e-02 1.421 0 0
Separation of Sister Chromatids R-HSA-2467813 4.221281e-02 1.375 0 0
Long-term potentiation R-HSA-9620244 3.841740e-02 1.415 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.114734e-02 1.386 0 0
Calmodulin induced events R-HSA-111933 4.067264e-02 1.391 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.967576e-02 1.401 0 0
CaM pathway R-HSA-111997 4.067264e-02 1.391 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.752325e-02 1.426 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.114734e-02 1.386 0 0
Sensory processing of sound R-HSA-9659379 4.147025e-02 1.382 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.246173e-02 1.372 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.246173e-02 1.372 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.246173e-02 1.372 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.246173e-02 1.372 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.246173e-02 1.372 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.327624e-02 1.364 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.374463e-02 1.359 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.573194e-02 1.340 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.579539e-02 1.339 0 0
PLC beta mediated events R-HSA-112043 4.681804e-02 1.330 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.687142e-02 1.329 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.687142e-02 1.329 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.687142e-02 1.329 0 0
Sodium/Proton exchangers R-HSA-425986 4.687142e-02 1.329 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.734695e-02 1.325 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.778064e-02 1.321 0 0
Repression of WNT target genes R-HSA-4641265 4.778064e-02 1.321 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.969949e-02 1.304 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.169991e-02 1.287 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.206906e-02 1.283 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.206906e-02 1.283 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.218660e-02 1.282 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.233224e-02 1.281 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.233224e-02 1.281 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 5.235002e-02 1.281 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 5.235002e-02 1.281 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.235002e-02 1.281 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 5.235002e-02 1.281 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.501715e-02 1.260 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.501715e-02 1.260 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.501715e-02 1.260 0 0
ALK mutants bind TKIs R-HSA-9700645 6.054622e-02 1.218 0 0
Formation of axial mesoderm R-HSA-9796292 5.880871e-02 1.231 0 0
mRNA Splicing R-HSA-72172 6.014305e-02 1.221 0 0
Ion homeostasis R-HSA-5578775 5.350704e-02 1.272 0 0
Signaling by EGFR R-HSA-177929 5.350704e-02 1.272 0 0
Calcineurin activates NFAT R-HSA-2025928 6.054622e-02 1.218 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.880871e-02 1.231 0 0
Muscle contraction R-HSA-397014 6.252931e-02 1.204 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.801970e-02 1.236 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.501715e-02 1.260 0 0
Unwinding of DNA R-HSA-176974 6.054622e-02 1.218 0 0
Base Excision Repair R-HSA-73884 6.382492e-02 1.195 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.467910e-02 1.189 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.467910e-02 1.189 0 0
Ephrin signaling R-HSA-3928664 6.467910e-02 1.189 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.467910e-02 1.189 0 0
Aggrephagy R-HSA-9646399 6.540653e-02 1.184 0 0
Nuclear import of Rev protein R-HSA-180746 6.688854e-02 1.175 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.688854e-02 1.175 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.688854e-02 1.175 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.688854e-02 1.175 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.747824e-02 1.171 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.762462e-02 1.170 0 0
Signaling by TGFBR3 R-HSA-9839373 7.025150e-02 1.153 0 0
Cellular responses to stress R-HSA-2262752 7.050460e-02 1.152 0 0
Cell-cell junction organization R-HSA-421270 7.059640e-02 1.151 0 0
MAPK family signaling cascades R-HSA-5683057 7.086656e-02 1.150 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 7.116707e-02 1.148 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.116707e-02 1.148 0 0
HDL assembly R-HSA-8963896 7.116707e-02 1.148 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.116707e-02 1.148 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.282562e-02 1.138 0 0
Developmental Biology R-HSA-1266738 7.299686e-02 1.137 1 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.503187e-02 1.125 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.531014e-02 1.123 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.531014e-02 1.123 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.531014e-02 1.123 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.531014e-02 1.123 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.531014e-02 1.123 0 0
Ca2+ pathway R-HSA-4086398 7.531824e-02 1.123 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.609816e-02 1.119 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.691366e-02 1.114 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.709524e-02 1.113 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.715120e-02 1.113 0 0
G-protein mediated events R-HSA-112040 7.954624e-02 1.099 0 0
FLT3 signaling in disease R-HSA-9682385 8.375797e-02 1.077 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.483631e-02 1.071 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.483631e-02 1.071 0 0
Regulation of TP53 Expression R-HSA-6804754 8.607968e-02 1.065 0 0
Potassium transport channels R-HSA-1296067 8.607968e-02 1.065 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.839380e-02 1.007 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.782667e-02 1.056 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.785390e-02 1.056 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.785390e-02 1.056 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.076017e-01 0.968 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.306714e-02 1.031 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.015246e-01 0.993 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.050013e-02 1.043 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.344792e-02 1.029 0 0
Nuclear RNA decay R-HSA-9930044 1.076017e-01 0.968 0 0
MTOR signalling R-HSA-165159 8.918842e-02 1.050 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.941752e-02 1.003 0 0
Autophagy R-HSA-9612973 8.698799e-02 1.061 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.650674e-02 1.015 0 0
Selective autophagy R-HSA-9663891 8.987061e-02 1.046 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.076017e-01 0.968 0 0
Signaling by ALK in cancer R-HSA-9700206 9.650674e-02 1.015 0 0
Protein ubiquitination R-HSA-8852135 8.780116e-02 1.056 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.839380e-02 1.007 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.679067e-02 1.062 0 0
Semaphorin interactions R-HSA-373755 9.870213e-02 1.006 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.870213e-02 1.006 0 0
Signaling by PTK6 R-HSA-8848021 9.870213e-02 1.006 0 0
Ca-dependent events R-HSA-111996 8.918842e-02 1.050 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.640215e-02 1.016 0 0
Cellular responses to stimuli R-HSA-8953897 8.676472e-02 1.062 0 0
Glycolysis R-HSA-70171 9.072828e-02 1.042 0 0
Interleukin-7 signaling R-HSA-1266695 8.785390e-02 1.056 0 0
Signaling by NOTCH R-HSA-157118 1.108126e-01 0.955 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.117713e-01 0.952 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.124867e-01 0.949 0 0
Transmission across Chemical Synapses R-HSA-112315 1.132045e-01 0.946 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.134194e-01 0.945 0 0
Signaling by ALK R-HSA-201556 1.134194e-01 0.945 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.144940e-01 0.941 0 0
KIT mutants bind TKIs R-HSA-9669921 1.144940e-01 0.941 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.144940e-01 0.941 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.144940e-01 0.941 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.144940e-01 0.941 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.144940e-01 0.941 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.144940e-01 0.941 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.144940e-01 0.941 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.144940e-01 0.941 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.144940e-01 0.941 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.144940e-01 0.941 0 0
Macroautophagy R-HSA-1632852 1.152631e-01 0.938 0 0
Opioid Signalling R-HSA-111885 1.156285e-01 0.937 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.159446e-01 0.936 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.162628e-01 0.935 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.165555e-01 0.933 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.192658e-01 0.923 0 0
snRNP Assembly R-HSA-191859 1.223497e-01 0.912 0 0
Metabolism of non-coding RNA R-HSA-194441 1.223497e-01 0.912 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.238974e-01 0.907 0 0
EPH-Ephrin signaling R-HSA-2682334 1.238974e-01 0.907 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.239307e-01 0.907 0 0
Netrin mediated repulsion signals R-HSA-418886 1.239307e-01 0.907 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.239307e-01 0.907 0 0
SOS-mediated signalling R-HSA-112412 1.239307e-01 0.907 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.239307e-01 0.907 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.244468e-01 0.905 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.245097e-01 0.905 0 0
Metabolism of RNA R-HSA-8953854 1.259349e-01 0.900 0 0
Co-inhibition by PD-1 R-HSA-389948 1.275292e-01 0.894 0 0
Diseases of DNA repair R-HSA-9675135 1.279896e-01 0.893 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.282797e-01 0.892 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.282797e-01 0.892 0 0
RAB geranylgeranylation R-HSA-8873719 1.317972e-01 0.880 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.330824e-01 0.876 0 0
OAS antiviral response R-HSA-8983711 1.330824e-01 0.876 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.332654e-01 0.875 0 0
Signaling by Hippo R-HSA-2028269 1.332654e-01 0.875 0 0
Specification of primordial germ cells R-HSA-9827857 1.332654e-01 0.875 0 0
Regulation of gap junction activity R-HSA-191650 1.661227e-01 0.780 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.661227e-01 0.780 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.661227e-01 0.780 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.661227e-01 0.780 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.661227e-01 0.780 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.515590e-01 0.819 0 0
Type I hemidesmosome assembly R-HSA-446107 1.515590e-01 0.819 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.550853e-01 0.809 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.550853e-01 0.809 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.516644e-01 0.819 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.516644e-01 0.819 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.710547e-01 0.767 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.533373e-01 0.814 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.685889e-01 0.773 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.685889e-01 0.773 0 0
Voltage gated Potassium channels R-HSA-1296072 1.721267e-01 0.764 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.624432e-01 0.789 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.558947e-01 0.807 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.520383e-01 0.818 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.797663e-01 0.745 0 0
Hedgehog 'off' state R-HSA-5610787 1.381479e-01 0.860 0 0
Polo-like kinase mediated events R-HSA-156711 1.516644e-01 0.819 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.783335e-01 0.749 0 0
Frs2-mediated activation R-HSA-170968 1.550853e-01 0.809 0 0
MAP2K and MAPK activation R-HSA-5674135 1.481413e-01 0.829 0 0
Dopamine receptors R-HSA-390651 1.661227e-01 0.780 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.515590e-01 0.819 0 0
cGMP effects R-HSA-418457 1.783335e-01 0.749 0 0
PKA activation R-HSA-163615 1.516644e-01 0.819 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.481413e-01 0.829 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.580281e-01 0.801 0 0
Sensory perception of sour taste R-HSA-9729555 1.661227e-01 0.780 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.520383e-01 0.818 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.661227e-01 0.780 0 0
Potassium Channels R-HSA-1296071 1.645343e-01 0.784 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.754467e-01 0.756 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 1.550853e-01 0.809 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.698605e-01 0.770 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.638965e-01 0.785 0 0
Membrane Trafficking R-HSA-199991 1.500963e-01 0.824 0 0
Specification of the neural plate border R-HSA-9834899 1.710547e-01 0.767 0 0
DNA Repair R-HSA-73894 1.734293e-01 0.761 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.515590e-01 0.819 0 0
PKA activation in glucagon signalling R-HSA-164378 1.516644e-01 0.819 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.387603e-01 0.858 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.417838e-01 0.848 0 0
Interleukin-1 family signaling R-HSA-446652 1.433908e-01 0.843 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.661227e-01 0.780 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.807019e-01 0.743 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.809104e-01 0.743 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.809104e-01 0.743 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.809104e-01 0.743 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.809104e-01 0.743 0 0
Glucose metabolism R-HSA-70326 1.819269e-01 0.740 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.828274e-01 0.738 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.844746e-01 0.734 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.844746e-01 0.734 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.867665e-01 0.729 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.875090e-01 0.727 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.158850e-01 0.666 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.158850e-01 0.666 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.158850e-01 0.666 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.158850e-01 0.666 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.158850e-01 0.666 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.158850e-01 0.666 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.158850e-01 0.666 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.158850e-01 0.666 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.158850e-01 0.666 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.056719e-01 0.515 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.056719e-01 0.515 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.056719e-01 0.515 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.056719e-01 0.515 0 0
Defective GALK1 causes GALCT2 R-HSA-5609976 3.056719e-01 0.515 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.056719e-01 0.515 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.056719e-01 0.515 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.056719e-01 0.515 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.056719e-01 0.515 0 0
Intestinal infectious diseases R-HSA-8942233 3.056719e-01 0.515 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.056719e-01 0.515 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.056719e-01 0.515 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.056719e-01 0.515 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.096869e-01 0.678 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.096869e-01 0.678 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.096869e-01 0.678 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.096869e-01 0.678 0 0
IRS activation R-HSA-74713 2.096869e-01 0.678 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.542107e-01 0.595 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.542107e-01 0.595 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.851823e-01 0.414 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.851823e-01 0.414 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.851823e-01 0.414 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.851823e-01 0.414 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.851823e-01 0.414 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.851823e-01 0.414 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.851823e-01 0.414 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.851823e-01 0.414 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.851823e-01 0.414 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.851823e-01 0.414 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.851823e-01 0.414 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.851823e-01 0.414 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.851823e-01 0.414 0 0
PI3K/AKT activation R-HSA-198203 2.116224e-01 0.674 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.989038e-01 0.524 0 0
STAT5 Activation R-HSA-9645135 2.989038e-01 0.524 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 2.989038e-01 0.524 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.989038e-01 0.524 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.433476e-01 0.614 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.433476e-01 0.614 0 0
DCC mediated attractive signaling R-HSA-418885 2.026576e-01 0.693 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.026576e-01 0.693 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.026576e-01 0.693 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.026576e-01 0.693 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.026576e-01 0.693 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.913422e-01 0.718 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.278847e-01 0.642 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.757607e-01 0.559 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.757607e-01 0.559 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.757607e-01 0.559 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.757607e-01 0.559 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.757607e-01 0.559 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.431440e-01 0.465 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.431440e-01 0.465 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 3.431440e-01 0.465 0 0
Axonal growth stimulation R-HSA-209563 4.555916e-01 0.341 0 0
Invadopodia formation R-HSA-8941237 4.555916e-01 0.341 0 0
Classical Kir channels R-HSA-1296053 4.555916e-01 0.341 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.555916e-01 0.341 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.555916e-01 0.341 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.555916e-01 0.341 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.555916e-01 0.341 0 0
MET activates PTPN11 R-HSA-8865999 4.555916e-01 0.341 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.538425e-01 0.595 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.538425e-01 0.595 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.978993e-01 0.704 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.085619e-01 0.511 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.085619e-01 0.511 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.085619e-01 0.511 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.085619e-01 0.511 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.085619e-01 0.511 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.085619e-01 0.511 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.085619e-01 0.511 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.864493e-01 0.413 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.864493e-01 0.413 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.864493e-01 0.413 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.009500e-01 0.697 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.360223e-01 0.627 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.794253e-01 0.554 0 0
Late endosomal microautophagy R-HSA-9615710 2.558719e-01 0.592 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.534309e-01 0.596 0 0
Activation of the pre-replicative complex R-HSA-68962 2.761506e-01 0.559 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.761506e-01 0.559 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.026558e-01 0.519 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.026558e-01 0.519 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.344378e-01 0.476 0 0
Lipophagy R-HSA-9613354 4.284540e-01 0.368 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.284540e-01 0.368 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.284540e-01 0.368 0 0
CASP8 activity is inhibited R-HSA-5218900 4.284540e-01 0.368 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.284540e-01 0.368 0 0
HCN channels R-HSA-1296061 5.179413e-01 0.286 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.179413e-01 0.286 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.179413e-01 0.286 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 5.179413e-01 0.286 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.179413e-01 0.286 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.717710e-01 0.566 0 0
EGFR downregulation R-HSA-182971 2.967853e-01 0.528 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.616925e-01 0.442 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.616925e-01 0.442 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.616925e-01 0.442 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.616925e-01 0.442 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.205557e-01 0.656 0 0
Erythropoietin activates RAS R-HSA-9027284 4.067267e-01 0.391 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.067267e-01 0.391 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.067267e-01 0.391 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.688881e-01 0.329 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.688881e-01 0.329 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.688881e-01 0.329 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.862439e-01 0.543 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.736162e-01 0.428 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.189945e-01 0.496 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.189945e-01 0.496 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.099945e-01 0.509 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.159539e-01 0.381 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.159539e-01 0.381 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.265340e-01 0.486 0 0
Translation initiation complex formation R-HSA-72649 3.432341e-01 0.464 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.375823e-01 0.472 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.869442e-01 0.412 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.427215e-01 0.354 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.075606e-01 0.295 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.075606e-01 0.295 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.075606e-01 0.295 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.075606e-01 0.295 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.769793e-01 0.424 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.350988e-01 0.475 0 0
HCMV Early Events R-HSA-9609690 2.484852e-01 0.605 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.677991e-01 0.330 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.012938e-01 0.397 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.443447e-01 0.264 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.443447e-01 0.264 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.443447e-01 0.264 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.298765e-01 0.276 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.839888e-01 0.315 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.203791e-01 0.284 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.203791e-01 0.284 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.076768e-01 0.294 0 0
PPARA activates gene expression R-HSA-1989781 4.454045e-01 0.351 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.793777e-01 0.319 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.583966e-01 0.253 0 0
Viral mRNA Translation R-HSA-192823 5.211325e-01 0.283 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.477902e-01 0.261 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.266344e-01 0.278 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.665922e-01 0.331 0 0
PKR-mediated signaling R-HSA-9833482 1.911778e-01 0.719 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.093998e-01 0.509 0 0
RNA Polymerase III Transcription R-HSA-74158 2.717710e-01 0.566 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.009500e-01 0.697 0 0
HIV Transcription Elongation R-HSA-167169 5.076768e-01 0.294 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.445445e-01 0.352 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.904454e-01 0.537 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.019145e-01 0.695 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.498482e-01 0.456 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.786230e-01 0.320 0 0
Integrin signaling R-HSA-354192 5.133167e-01 0.290 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.076768e-01 0.294 0 0
Signaling by ERBB2 R-HSA-1227986 4.449236e-01 0.352 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.538425e-01 0.595 0 0
G-protein beta:gamma signalling R-HSA-397795 2.009500e-01 0.697 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.913422e-01 0.718 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.583966e-01 0.253 0 0
G0 and Early G1 R-HSA-1538133 4.907432e-01 0.309 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.354654e-01 0.271 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.564182e-01 0.591 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.116224e-01 0.674 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.757607e-01 0.559 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.072787e-01 0.512 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.688881e-01 0.329 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.167694e-01 0.664 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.109616e-01 0.386 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.133167e-01 0.290 0 0
Signaling by FGFR4 R-HSA-5654743 4.260306e-01 0.371 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.132679e-01 0.384 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.699109e-01 0.328 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.909517e-01 0.408 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.909517e-01 0.408 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.542107e-01 0.595 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.542107e-01 0.595 0 0
Regulation of CDH11 function R-HSA-9762292 2.116224e-01 0.674 0 0
Formation of apoptosome R-HSA-111458 2.116224e-01 0.674 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.431440e-01 0.465 0 0
DNA strand elongation R-HSA-69190 3.177037e-01 0.498 0 0
Peptide chain elongation R-HSA-156902 2.091205e-01 0.680 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.688881e-01 0.329 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.427215e-01 0.354 0 0
Eukaryotic Translation Termination R-HSA-72764 3.131924e-01 0.504 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.907432e-01 0.309 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.871361e-01 0.312 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.477902e-01 0.261 0 0
Signaling by FGFR3 R-HSA-5654741 4.648163e-01 0.333 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.828106e-01 0.417 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.384051e-01 0.269 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.085619e-01 0.511 0 0
p75NTR signals via NF-kB R-HSA-193639 2.026576e-01 0.693 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.159539e-01 0.381 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.500438e-01 0.602 0 0
S Phase R-HSA-69242 3.716014e-01 0.430 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.757607e-01 0.559 0 0
Adrenoceptors R-HSA-390696 3.864493e-01 0.413 0 0
WNT mediated activation of DVL R-HSA-201688 4.284540e-01 0.368 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.082915e-01 0.681 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.067267e-01 0.391 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.699109e-01 0.328 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.618205e-01 0.336 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.762714e-01 0.322 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.384051e-01 0.269 0 0
HIV Life Cycle R-HSA-162587 5.536112e-01 0.257 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.762714e-01 0.322 0 0
Mitophagy R-HSA-5205647 5.571415e-01 0.254 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.427215e-01 0.354 0 0
Interleukin-2 signaling R-HSA-9020558 5.075606e-01 0.295 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.443447e-01 0.264 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.406382e-01 0.267 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.809632e-01 0.318 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.031501e-01 0.395 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.411080e-01 0.618 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.116224e-01 0.674 0 0
Signal attenuation R-HSA-74749 2.116224e-01 0.674 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.124270e-01 0.673 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.085619e-01 0.511 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.360223e-01 0.627 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.558719e-01 0.592 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.265340e-01 0.486 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.814535e-01 0.419 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.411080e-01 0.618 0 0
Apoptotic factor-mediated response R-HSA-111471 5.298765e-01 0.276 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.476166e-01 0.606 0 0
Signaling by Hedgehog R-HSA-5358351 3.391393e-01 0.470 0 0
PTEN Regulation R-HSA-6807070 3.496560e-01 0.456 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.261631e-01 0.487 0 0
Prolonged ERK activation events R-HSA-169893 2.278847e-01 0.642 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.989038e-01 0.524 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.431440e-01 0.465 0 0
Disorders of Developmental Biology R-HSA-9675151 2.538425e-01 0.595 0 0
Cardiogenesis R-HSA-9733709 2.009500e-01 0.697 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.026558e-01 0.519 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.284540e-01 0.368 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.388341e-01 0.470 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.889063e-01 0.410 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.688881e-01 0.329 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.699109e-01 0.328 0 0
Formation of the posterior neural plate R-HSA-9832991 5.075606e-01 0.295 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.583966e-01 0.253 0 0
IRS-mediated signalling R-HSA-112399 5.337474e-01 0.273 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.571415e-01 0.254 0 0
IGF1R signaling cascade R-HSA-2428924 5.118368e-01 0.291 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.538425e-01 0.595 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.601066e-01 0.444 0 0
Cellular response to starvation R-HSA-9711097 5.640141e-01 0.249 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.026576e-01 0.693 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.699109e-01 0.328 0 0
Signaling by FGFR in disease R-HSA-1226099 5.386932e-01 0.269 0 0
Platelet calcium homeostasis R-HSA-418360 2.558719e-01 0.592 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.728267e-01 0.428 0 0
Signaling by WNT in cancer R-HSA-4791275 4.907432e-01 0.309 0 0
Biotin transport and metabolism R-HSA-196780 4.067267e-01 0.391 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.249348e-01 0.280 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.848852e-01 0.415 0 0
Regulated Necrosis R-HSA-5218859 3.227241e-01 0.491 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.116224e-01 0.674 0 0
Pervasive developmental disorders R-HSA-9005895 3.085619e-01 0.511 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.085619e-01 0.511 0 0
Disorders of Nervous System Development R-HSA-9697154 3.085619e-01 0.511 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.864493e-01 0.413 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.009500e-01 0.697 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.742724e-01 0.427 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.616925e-01 0.442 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.067267e-01 0.391 0 0
Cilium Assembly R-HSA-5617833 2.039650e-01 0.690 0 0
Signalling to ERKs R-HSA-187687 2.534309e-01 0.596 0 0
Generation of second messenger molecules R-HSA-202433 3.479324e-01 0.459 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.869442e-01 0.412 0 0
Signaling by TGFB family members R-HSA-9006936 2.612987e-01 0.583 0 0
Signaling by NODAL R-HSA-1181150 3.616925e-01 0.442 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.691068e-01 0.329 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.203791e-01 0.284 0 0
Glycogen metabolism R-HSA-8982491 5.076768e-01 0.294 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.281979e-01 0.277 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.723279e-01 0.565 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.057689e-01 0.687 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.989038e-01 0.524 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.538425e-01 0.595 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.904454e-01 0.537 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.427215e-01 0.354 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.137916e-01 0.503 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.076768e-01 0.294 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.076768e-01 0.294 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.451184e-01 0.264 0 0
DNA Replication R-HSA-69306 2.032158e-01 0.692 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.431440e-01 0.465 0 0
mRNA Editing R-HSA-75072 4.284540e-01 0.368 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.386585e-01 0.358 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.354654e-01 0.271 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.136308e-01 0.383 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.016211e-01 0.695 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.465769e-01 0.262 0 0
G1/S Transition R-HSA-69206 3.467369e-01 0.460 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.210462e-01 0.376 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.341351e-01 0.272 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.077650e-01 0.294 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.648450e-01 0.333 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.158850e-01 0.666 0 0
Inhibition of PKR R-HSA-169131 2.158850e-01 0.666 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.056719e-01 0.515 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.851823e-01 0.414 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.851823e-01 0.414 0 0
C6 deamination of adenosine R-HSA-75102 3.851823e-01 0.414 0 0
Protein hydroxylation R-HSA-9629569 1.913422e-01 0.718 0 0
Negative regulation of FLT3 R-HSA-9706369 2.278847e-01 0.642 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.555916e-01 0.341 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.555916e-01 0.341 0 0
Signaling by LTK R-HSA-9842663 3.085619e-01 0.511 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.803616e-01 0.552 0 0
Regulation by c-FLIP R-HSA-3371378 3.864493e-01 0.413 0 0
mTORC1-mediated signalling R-HSA-166208 2.565739e-01 0.591 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 3.414798e-01 0.467 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.414798e-01 0.467 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.072787e-01 0.512 0 0
Transmission across Electrical Synapses R-HSA-112307 5.179413e-01 0.286 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.179413e-01 0.286 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.179413e-01 0.286 0 0
Alanine metabolism R-HSA-8964540 5.179413e-01 0.286 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.179413e-01 0.286 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.179413e-01 0.286 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.904454e-01 0.537 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.688881e-01 0.329 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.189945e-01 0.496 0 0
Differentiation of T cells R-HSA-9945266 4.386585e-01 0.358 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.386585e-01 0.358 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.814535e-01 0.419 0 0
Ethanol oxidation R-HSA-71384 4.427215e-01 0.354 0 0
Signaling by APC mutants R-HSA-4839744 5.075606e-01 0.295 0 0
Gap junction trafficking and regulation R-HSA-157858 3.909517e-01 0.408 0 0
Sodium/Calcium exchangers R-HSA-425561 5.443447e-01 0.264 0 0
NF-kB is activated and signals survival R-HSA-209560 5.443447e-01 0.264 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.443447e-01 0.264 0 0
Signaling by AXIN mutants R-HSA-4839735 5.443447e-01 0.264 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.976910e-01 0.303 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.451184e-01 0.264 0 0
PI3K Cascade R-HSA-109704 5.583406e-01 0.253 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.940564e-01 0.712 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.019145e-01 0.695 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.133167e-01 0.290 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.676496e-01 0.435 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.736162e-01 0.428 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.176072e-01 0.286 0 0
Interferon Signaling R-HSA-913531 4.125993e-01 0.384 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.978993e-01 0.704 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.176072e-01 0.286 0 0
GAB1 signalosome R-HSA-180292 3.072787e-01 0.512 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.375449e-01 0.624 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.065024e-01 0.391 0 0
Protein methylation R-HSA-8876725 4.067267e-01 0.391 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.076768e-01 0.294 0 0
Downstream signal transduction R-HSA-186763 4.677991e-01 0.330 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.734170e-01 0.325 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.116224e-01 0.674 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.026576e-01 0.693 0 0
TRP channels R-HSA-3295583 1.978993e-01 0.704 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.864493e-01 0.413 0 0
tRNA processing in the nucleus R-HSA-6784531 4.786230e-01 0.320 0 0
Signaling by ERBB4 R-HSA-1236394 2.995823e-01 0.523 0 0
MHC class II antigen presentation R-HSA-2132295 3.137916e-01 0.503 0 0
Formation of the nephric duct R-HSA-9830364 3.261631e-01 0.487 0 0
Co-stimulation by CD28 R-HSA-389356 2.461261e-01 0.609 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.427818e-01 0.265 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.542107e-01 0.595 0 0
Nef and signal transduction R-HSA-164944 2.989038e-01 0.524 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.414798e-01 0.467 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.179680e-01 0.662 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.160347e-01 0.665 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.284540e-01 0.368 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.284540e-01 0.368 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.179413e-01 0.286 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.067267e-01 0.391 0 0
Carnitine shuttle R-HSA-200425 4.691068e-01 0.329 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.015614e-01 0.696 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.354789e-01 0.628 0 0
Signaling by NTRKs R-HSA-166520 3.716014e-01 0.430 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.286090e-01 0.483 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.203791e-01 0.284 0 0
HCMV Late Events R-HSA-9610379 3.824143e-01 0.417 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.583966e-01 0.253 0 0
Integration of provirus R-HSA-162592 5.443447e-01 0.264 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.003527e-01 0.301 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.166743e-01 0.664 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.056719e-01 0.515 0 0
DSCAM interactions R-HSA-376172 3.851823e-01 0.414 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.116224e-01 0.674 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.555916e-01 0.341 0 0
Alpha-defensins R-HSA-1462054 3.864493e-01 0.413 0 0
Dimerization of procaspase-8 R-HSA-69416 3.864493e-01 0.413 0 0
Maturation of nucleoprotein R-HSA-9683610 3.414798e-01 0.467 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.019145e-01 0.695 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.072787e-01 0.512 0 0
Syndecan interactions R-HSA-3000170 2.794253e-01 0.554 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.284540e-01 0.368 0 0
ARMS-mediated activation R-HSA-170984 4.284540e-01 0.368 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.889063e-01 0.410 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.386585e-01 0.358 0 0
Synthesis of PI R-HSA-1483226 5.075606e-01 0.295 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.839888e-01 0.315 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.575649e-01 0.340 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.026558e-01 0.519 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.009500e-01 0.697 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.743532e-01 0.562 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.978993e-01 0.704 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.118368e-01 0.291 0 0
Signal regulatory protein family interactions R-HSA-391160 3.742724e-01 0.427 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.762714e-01 0.322 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.601066e-01 0.444 0 0
Histamine receptors R-HSA-390650 4.555916e-01 0.341 0 0
Maturation of nucleoprotein R-HSA-9694631 3.344378e-01 0.476 0 0
G1/S-Specific Transcription R-HSA-69205 2.717710e-01 0.566 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.159539e-01 0.381 0 0
PECAM1 interactions R-HSA-210990 5.075606e-01 0.295 0 0
Tie2 Signaling R-HSA-210993 5.298765e-01 0.276 0 0
Selenocysteine synthesis R-HSA-2408557 4.948445e-01 0.306 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.325822e-01 0.274 0 0
Stimuli-sensing channels R-HSA-2672351 3.899435e-01 0.409 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.298765e-01 0.276 0 0
Formation of the anterior neural plate R-HSA-9823739 4.067267e-01 0.391 0 0
PI Metabolism R-HSA-1483255 4.019230e-01 0.396 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.431440e-01 0.465 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.431440e-01 0.465 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.479324e-01 0.459 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.159539e-01 0.381 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.674043e-01 0.435 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.065024e-01 0.391 0 0
Gap junction assembly R-HSA-190861 5.571415e-01 0.254 0 0
Signaling by Interleukins R-HSA-449147 4.046017e-01 0.393 0 0
Signaling by Leptin R-HSA-2586552 2.116224e-01 0.674 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.075606e-01 0.295 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.466907e-01 0.460 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.072787e-01 0.512 0 0
Influenza Infection R-HSA-168255 4.521433e-01 0.345 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.414798e-01 0.467 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.354654e-01 0.271 0 0
Metal ion SLC transporters R-HSA-425410 5.217002e-01 0.283 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.962523e-01 0.402 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.124735e-01 0.385 0 0
Interleukin-12 signaling R-HSA-9020591 5.688989e-01 0.245 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.571415e-01 0.254 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.298765e-01 0.276 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.691790e-01 0.245 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.691790e-01 0.245 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.691790e-01 0.245 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.691790e-01 0.245 0 0
Activation of AMPA receptors R-HSA-399710 5.731535e-01 0.242 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.731535e-01 0.242 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.731535e-01 0.242 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.731535e-01 0.242 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.731535e-01 0.242 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.731535e-01 0.242 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.731535e-01 0.242 0 0
Suppression of autophagy R-HSA-9636569 5.731535e-01 0.242 0 0
PTK6 Down-Regulation R-HSA-8849472 5.731535e-01 0.242 0 0
NrCAM interactions R-HSA-447038 5.731535e-01 0.242 0 0
Co-inhibition by BTLA R-HSA-9927353 5.731535e-01 0.242 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.731535e-01 0.242 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.731535e-01 0.242 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.791657e-01 0.237 0 0
Polymerase switching R-HSA-69091 5.791657e-01 0.237 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.791657e-01 0.237 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.791657e-01 0.237 0 0
Leading Strand Synthesis R-HSA-69109 5.791657e-01 0.237 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.791657e-01 0.237 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.791657e-01 0.237 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.791657e-01 0.237 0 0
Estrogen biosynthesis R-HSA-193144 5.791657e-01 0.237 0 0
Interleukin-15 signaling R-HSA-8983432 5.791657e-01 0.237 0 0
HCMV Infection R-HSA-9609646 5.819933e-01 0.235 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.858473e-01 0.232 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.858473e-01 0.232 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.858473e-01 0.232 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.863688e-01 0.232 0 0
Integration of energy metabolism R-HSA-163685 5.874272e-01 0.231 0 0
Telomere Extension By Telomerase R-HSA-171319 5.925131e-01 0.227 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.925131e-01 0.227 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.925131e-01 0.227 0 0
HIV elongation arrest and recovery R-HSA-167287 5.925131e-01 0.227 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.925131e-01 0.227 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.925131e-01 0.227 0 0
Pyroptosis R-HSA-5620971 5.925131e-01 0.227 0 0
Orc1 removal from chromatin R-HSA-68949 5.936772e-01 0.226 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.989147e-01 0.223 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.989147e-01 0.223 0 0
Gap junction trafficking R-HSA-190828 6.050057e-01 0.218 0 0
Host Interactions of HIV factors R-HSA-162909 6.090451e-01 0.215 0 0
Smooth Muscle Contraction R-HSA-445355 6.107959e-01 0.214 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.119907e-01 0.213 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.119907e-01 0.213 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.119907e-01 0.213 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.119907e-01 0.213 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.119907e-01 0.213 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.119907e-01 0.213 0 0
Processing of SMDT1 R-HSA-8949664 6.119907e-01 0.213 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.119907e-01 0.213 0 0
Interleukin-6 signaling R-HSA-1059683 6.119907e-01 0.213 0 0
Signalling to RAS R-HSA-167044 6.121805e-01 0.213 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.121805e-01 0.213 0 0
Adipogenesis R-HSA-9843745 6.145110e-01 0.211 0 0
Signaling by Erythropoietin R-HSA-9006335 6.150820e-01 0.211 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.150820e-01 0.211 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.150820e-01 0.211 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.150820e-01 0.211 0 0
Heme signaling R-HSA-9707616 6.163096e-01 0.210 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.181182e-01 0.209 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.189456e-01 0.208 0 0
Hedgehog 'on' state R-HSA-5632684 6.215733e-01 0.207 0 0
Plus-strand DNA synthesis R-HSA-164525 6.220448e-01 0.206 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.220448e-01 0.206 0 0
PKB-mediated events R-HSA-109703 6.220448e-01 0.206 0 0
PDE3B signalling R-HSA-165160 6.220448e-01 0.206 0 0
Signaling by MAPK mutants R-HSA-9652817 6.220448e-01 0.206 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.220448e-01 0.206 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.220448e-01 0.206 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.220448e-01 0.206 0 0
NGF-independant TRKA activation R-HSA-187024 6.220448e-01 0.206 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.220448e-01 0.206 0 0
Formation of the Editosome R-HSA-75094 6.220448e-01 0.206 0 0
Phosphorylation of Emi1 R-HSA-176417 6.220448e-01 0.206 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.220448e-01 0.206 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.220448e-01 0.206 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.220448e-01 0.206 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.220448e-01 0.206 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.220448e-01 0.206 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.231742e-01 0.205 0 0
Neutrophil degranulation R-HSA-6798695 6.294992e-01 0.201 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.360964e-01 0.196 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.368555e-01 0.196 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.368555e-01 0.196 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.368555e-01 0.196 0 0
DAP12 signaling R-HSA-2424491 6.368555e-01 0.196 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.368555e-01 0.196 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.368555e-01 0.196 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.373638e-01 0.196 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.373638e-01 0.196 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.373638e-01 0.196 0 0
Prolactin receptor signaling R-HSA-1170546 6.428202e-01 0.192 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.428202e-01 0.192 0 0
Removal of the Flap Intermediate R-HSA-69166 6.428202e-01 0.192 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.428202e-01 0.192 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.428202e-01 0.192 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.428202e-01 0.192 0 0
Physiological factors R-HSA-5578768 6.428202e-01 0.192 0 0
P2Y receptors R-HSA-417957 6.428202e-01 0.192 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.438359e-01 0.191 0 0
Insulin receptor signalling cascade R-HSA-74751 6.470812e-01 0.189 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.571712e-01 0.182 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.578116e-01 0.182 0 0
Budding and maturation of HIV virion R-HSA-162588 6.578116e-01 0.182 0 0
Signaling by FGFR1 R-HSA-5654736 6.597259e-01 0.181 0 0
Signaling by KIT in disease R-HSA-9669938 6.613786e-01 0.180 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.613786e-01 0.180 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.613786e-01 0.180 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.613786e-01 0.180 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.613786e-01 0.180 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.642184e-01 0.178 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.653387e-01 0.177 0 0
Uncoating of the HIV Virion R-HSA-162585 6.653387e-01 0.177 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.653387e-01 0.177 0 0
Abacavir transmembrane transport R-HSA-2161517 6.653387e-01 0.177 0 0
CREB phosphorylation R-HSA-199920 6.653387e-01 0.177 0 0
NADPH regeneration R-HSA-389542 6.653387e-01 0.177 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.653387e-01 0.177 0 0
Lipid particle organization R-HSA-8964572 6.653387e-01 0.177 0 0
HIV Infection R-HSA-162906 6.708425e-01 0.173 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.716805e-01 0.173 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.716805e-01 0.173 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.716805e-01 0.173 0 0
p38MAPK events R-HSA-171007 6.716805e-01 0.173 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.716805e-01 0.173 0 0
Signaling by Activin R-HSA-1502540 6.716805e-01 0.173 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.716805e-01 0.173 0 0
Regulation of insulin secretion R-HSA-422356 6.727997e-01 0.172 0 0
Intraflagellar transport R-HSA-5620924 6.746826e-01 0.171 0 0
GPER1 signaling R-HSA-9634597 6.746826e-01 0.171 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.787830e-01 0.168 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.842186e-01 0.165 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.842186e-01 0.165 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.842186e-01 0.165 0 0
Growth hormone receptor signaling R-HSA-982772 6.842186e-01 0.165 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.928394e-01 0.159 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.928394e-01 0.159 0 0
Protein folding R-HSA-391251 6.942451e-01 0.158 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.986183e-01 0.156 0 0
Phosphorylation of the APC/C R-HSA-176412 6.986183e-01 0.156 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.986183e-01 0.156 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.986183e-01 0.156 0 0
Activation of SMO R-HSA-5635838 6.986183e-01 0.156 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.986183e-01 0.156 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.986183e-01 0.156 0 0
Fructose catabolism R-HSA-70350 6.986183e-01 0.156 0 0
Regulation of BACH1 activity R-HSA-9708530 6.986183e-01 0.156 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.986183e-01 0.156 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.986183e-01 0.156 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.986183e-01 0.156 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.036755e-01 0.153 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.036755e-01 0.153 0 0
Disinhibition of SNARE formation R-HSA-114516 7.036755e-01 0.153 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.036755e-01 0.153 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.036755e-01 0.153 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.036755e-01 0.153 0 0
PTK6 Expression R-HSA-8849473 7.036755e-01 0.153 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.036755e-01 0.153 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.036755e-01 0.153 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.036755e-01 0.153 0 0
Activation of TRKA receptors R-HSA-187015 7.036755e-01 0.153 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.036755e-01 0.153 0 0
Glycoprotein hormones R-HSA-209822 7.036755e-01 0.153 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.036755e-01 0.153 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.036755e-01 0.153 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.036755e-01 0.153 0 0
CHL1 interactions R-HSA-447041 7.036755e-01 0.153 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.036755e-01 0.153 0 0
Transcription of the HIV genome R-HSA-167172 7.041515e-01 0.152 0 0
Deadenylation of mRNA R-HSA-429947 7.058874e-01 0.151 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.058874e-01 0.151 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.058874e-01 0.151 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.058874e-01 0.151 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.063935e-01 0.151 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.096900e-01 0.149 0 0
Adaptive Immune System R-HSA-1280218 7.115361e-01 0.148 0 0
Striated Muscle Contraction R-HSA-390522 7.156591e-01 0.145 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.156591e-01 0.145 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.156591e-01 0.145 0 0
TCR signaling R-HSA-202403 7.193515e-01 0.143 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.236951e-01 0.140 0 0
Phase 2 - plateau phase R-HSA-5576893 7.236951e-01 0.140 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.236951e-01 0.140 0 0
Coenzyme A biosynthesis R-HSA-196783 7.236951e-01 0.140 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.236951e-01 0.140 0 0
Synthesis of PG R-HSA-1483148 7.236951e-01 0.140 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.263977e-01 0.139 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.263977e-01 0.139 0 0
Gastrulation R-HSA-9758941 7.269151e-01 0.139 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.286096e-01 0.138 0 0
Interleukin-12 family signaling R-HSA-447115 7.286153e-01 0.138 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.324584e-01 0.135 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.359361e-01 0.133 0 0
Vesicle-mediated transport R-HSA-5653656 7.373914e-01 0.132 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.376227e-01 0.132 0 0
Minus-strand DNA synthesis R-HSA-164516 7.376227e-01 0.132 0 0
RSK activation R-HSA-444257 7.376227e-01 0.132 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.376227e-01 0.132 0 0
Formation of annular gap junctions R-HSA-196025 7.376227e-01 0.132 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.376227e-01 0.132 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.376227e-01 0.132 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.376227e-01 0.132 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.376227e-01 0.132 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.376227e-01 0.132 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.376227e-01 0.132 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.376227e-01 0.132 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.376227e-01 0.132 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.376227e-01 0.132 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.376227e-01 0.132 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.402792e-01 0.131 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.408666e-01 0.130 0 0
Signaling by FGFR2 R-HSA-5654738 7.410073e-01 0.130 0 0
TBC/RABGAPs R-HSA-8854214 7.414091e-01 0.130 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.430451e-01 0.129 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.457697e-01 0.127 0 0
Myogenesis R-HSA-525793 7.457697e-01 0.127 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.469839e-01 0.127 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.469839e-01 0.127 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.469839e-01 0.127 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.469839e-01 0.127 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.469839e-01 0.127 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.498895e-01 0.125 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.500268e-01 0.125 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.500268e-01 0.125 0 0
Oncogene Induced Senescence R-HSA-2559585 7.500268e-01 0.125 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.500672e-01 0.125 0 0
Amine ligand-binding receptors R-HSA-375280 7.562815e-01 0.121 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.632998e-01 0.117 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.640295e-01 0.117 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.640295e-01 0.117 0 0
Cristae formation R-HSA-8949613 7.640295e-01 0.117 0 0
GPVI-mediated activation cascade R-HSA-114604 7.659730e-01 0.116 0 0
Triglyceride catabolism R-HSA-163560 7.659730e-01 0.116 0 0
RUNX2 regulates bone development R-HSA-8941326 7.659730e-01 0.116 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.665422e-01 0.115 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.676826e-01 0.115 0 0
Gap junction degradation R-HSA-190873 7.676826e-01 0.115 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.676826e-01 0.115 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.676826e-01 0.115 0 0
Interleukin-1 processing R-HSA-448706 7.676826e-01 0.115 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.676826e-01 0.115 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.676826e-01 0.115 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.676826e-01 0.115 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.676826e-01 0.115 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.676826e-01 0.115 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.676826e-01 0.115 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.676826e-01 0.115 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.676826e-01 0.115 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.676826e-01 0.115 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.676826e-01 0.115 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.676826e-01 0.115 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.685650e-01 0.114 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.685650e-01 0.114 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.685650e-01 0.114 0 0
Mismatch Repair R-HSA-5358508 7.685650e-01 0.114 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.685650e-01 0.114 0 0
G alpha (s) signalling events R-HSA-418555 7.701878e-01 0.113 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.705031e-01 0.113 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.705031e-01 0.113 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.705031e-01 0.113 0 0
Ion transport by P-type ATPases R-HSA-936837 7.705566e-01 0.113 0 0
Ion channel transport R-HSA-983712 7.719212e-01 0.112 0 0
Ribosome-associated quality control R-HSA-9948299 7.763296e-01 0.110 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.812082e-01 0.107 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.812082e-01 0.107 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.812082e-01 0.107 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.840827e-01 0.106 0 0
Regulation of signaling by CBL R-HSA-912631 7.885240e-01 0.103 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.885240e-01 0.103 0 0
The NLRP3 inflammasome R-HSA-844456 7.885240e-01 0.103 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.885240e-01 0.103 0 0
Binding and entry of HIV virion R-HSA-173107 7.943002e-01 0.100 0 0
2-LTR circle formation R-HSA-164843 7.943002e-01 0.100 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.943002e-01 0.100 0 0
DNA replication initiation R-HSA-68952 7.943002e-01 0.100 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.943002e-01 0.100 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.943002e-01 0.100 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.943002e-01 0.100 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.943002e-01 0.100 0 0
Metabolism of serotonin R-HSA-380612 7.943002e-01 0.100 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.943002e-01 0.100 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.943002e-01 0.100 0 0
Pexophagy R-HSA-9664873 7.943002e-01 0.100 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.943002e-01 0.100 0 0
Maturation of spike protein R-HSA-9683686 7.943002e-01 0.100 0 0
Sperm Motility And Taxes R-HSA-1300642 7.943002e-01 0.100 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.943002e-01 0.100 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.943002e-01 0.100 0 0
Peptide hormone biosynthesis R-HSA-209952 7.943002e-01 0.100 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.943002e-01 0.100 0 0
Josephin domain DUBs R-HSA-5689877 7.943002e-01 0.100 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.970309e-01 0.099 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.970309e-01 0.099 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.970309e-01 0.099 0 0
Interleukin-1 signaling R-HSA-9020702 7.985543e-01 0.098 0 0
Developmental Cell Lineages R-HSA-9734767 7.987270e-01 0.098 0 0
Kidney development R-HSA-9830369 8.045183e-01 0.094 0 0
Interferon gamma signaling R-HSA-877300 8.062371e-01 0.094 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.069493e-01 0.093 0 0
Nephrin family interactions R-HSA-373753 8.069493e-01 0.093 0 0
Stabilization of p53 R-HSA-69541 8.090477e-01 0.092 0 0
NGF-stimulated transcription R-HSA-9031628 8.093604e-01 0.092 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.124657e-01 0.090 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.124657e-01 0.090 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.178695e-01 0.087 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.178695e-01 0.087 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.178695e-01 0.087 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.178695e-01 0.087 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.178695e-01 0.087 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.178695e-01 0.087 0 0
Bicarbonate transporters R-HSA-425381 8.178695e-01 0.087 0 0
Transport of RCbl within the body R-HSA-9758890 8.178695e-01 0.087 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.178695e-01 0.087 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.178695e-01 0.087 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.178695e-01 0.087 0 0
LGI-ADAM interactions R-HSA-5682910 8.178695e-01 0.087 0 0
Suppression of apoptosis R-HSA-9635465 8.178695e-01 0.087 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.178695e-01 0.087 0 0
SARS-CoV Infections R-HSA-9679506 8.197799e-01 0.086 0 0
Degradation of CDH1 R-HSA-9766229 8.210855e-01 0.086 0 0
Inositol phosphate metabolism R-HSA-1483249 8.213511e-01 0.085 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.218854e-01 0.085 0 0
Interleukin-2 family signaling R-HSA-451927 8.218854e-01 0.085 0 0
Extension of Telomeres R-HSA-180786 8.224020e-01 0.085 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.224020e-01 0.085 0 0
Triglyceride metabolism R-HSA-8979227 8.224020e-01 0.085 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.239301e-01 0.084 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.239301e-01 0.084 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.239301e-01 0.084 0 0
Lagging Strand Synthesis R-HSA-69186 8.239301e-01 0.084 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.239301e-01 0.084 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.239301e-01 0.084 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.239301e-01 0.084 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.239301e-01 0.084 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.239301e-01 0.084 0 0
Basigin interactions R-HSA-210991 8.239301e-01 0.084 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.266230e-01 0.083 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.266230e-01 0.083 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.320414e-01 0.080 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.326930e-01 0.080 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.340014e-01 0.079 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.344892e-01 0.079 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.387394e-01 0.076 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.387394e-01 0.076 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.387394e-01 0.076 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.387394e-01 0.076 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.387394e-01 0.076 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.387394e-01 0.076 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.387394e-01 0.076 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.387394e-01 0.076 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.387394e-01 0.076 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.395556e-01 0.076 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.395556e-01 0.076 0 0
Attachment and Entry R-HSA-9694614 8.395556e-01 0.076 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.398547e-01 0.076 0 0
Toll-like Receptor Cascades R-HSA-168898 8.424664e-01 0.074 0 0
Aquaporin-mediated transport R-HSA-445717 8.424997e-01 0.074 0 0
The phototransduction cascade R-HSA-2514856 8.427857e-01 0.074 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.436296e-01 0.074 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.436296e-01 0.074 0 0
Intra-Golgi traffic R-HSA-6811438 8.454210e-01 0.073 0 0
Translation of Structural Proteins R-HSA-9683701 8.454210e-01 0.073 0 0
Neurotransmitter release cycle R-HSA-112310 8.482274e-01 0.071 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.498497e-01 0.071 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.507406e-01 0.070 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.508926e-01 0.070 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.511710e-01 0.070 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.511710e-01 0.070 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.511710e-01 0.070 0 0
Signaling by PDGF R-HSA-186797 8.518349e-01 0.070 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.522036e-01 0.069 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.527952e-01 0.069 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.527952e-01 0.069 0 0
FGFR2 alternative splicing R-HSA-6803529 8.539133e-01 0.069 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.539133e-01 0.069 0 0
Fructose metabolism R-HSA-5652084 8.539133e-01 0.069 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.561705e-01 0.067 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.572190e-01 0.067 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.572190e-01 0.067 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.572190e-01 0.067 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.572190e-01 0.067 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.572190e-01 0.067 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.572190e-01 0.067 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.572190e-01 0.067 0 0
MET activates RAS signaling R-HSA-8851805 8.572190e-01 0.067 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.572190e-01 0.067 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.572190e-01 0.067 0 0
Regulation of IFNG signaling R-HSA-877312 8.572190e-01 0.067 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.572190e-01 0.067 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.572190e-01 0.067 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.579020e-01 0.067 0 0
Circadian clock R-HSA-9909396 8.583551e-01 0.066 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.607121e-01 0.065 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.612181e-01 0.065 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.616756e-01 0.065 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.616756e-01 0.065 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.622685e-01 0.064 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.622685e-01 0.064 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.637129e-01 0.064 0 0
Potential therapeutics for SARS R-HSA-9679191 8.657190e-01 0.063 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.670886e-01 0.062 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.670886e-01 0.062 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.678341e-01 0.062 0 0
Signaling by NOTCH4 R-HSA-9013694 8.686375e-01 0.061 0 0
rRNA processing R-HSA-72312 8.702961e-01 0.060 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.704093e-01 0.060 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.712471e-01 0.060 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.721343e-01 0.059 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.735818e-01 0.059 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.735818e-01 0.059 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.735818e-01 0.059 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.735818e-01 0.059 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.735818e-01 0.059 0 0
Chylomicron remodeling R-HSA-8963901 8.735818e-01 0.059 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.735818e-01 0.059 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.735818e-01 0.059 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.735818e-01 0.059 0 0
Signal amplification R-HSA-392518 8.744260e-01 0.058 0 0
Hyaluronan metabolism R-HSA-2142845 8.744260e-01 0.058 0 0
RA biosynthesis pathway R-HSA-5365859 8.744260e-01 0.058 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.744260e-01 0.058 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.757666e-01 0.058 0 0
Cyclin D associated events in G1 R-HSA-69231 8.757666e-01 0.058 0 0
G1 Phase R-HSA-69236 8.757666e-01 0.058 0 0
DAP12 interactions R-HSA-2172127 8.757666e-01 0.058 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.762050e-01 0.057 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.762050e-01 0.057 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.771920e-01 0.057 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.791637e-01 0.056 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.791637e-01 0.056 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.791637e-01 0.056 0 0
Interleukin-6 family signaling R-HSA-6783589 8.791637e-01 0.056 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.831649e-01 0.054 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.843857e-01 0.053 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.843857e-01 0.053 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.846680e-01 0.053 0 0
Immune System R-HSA-168256 8.855396e-01 0.053 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.880703e-01 0.052 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.880703e-01 0.052 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.880703e-01 0.052 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.880703e-01 0.052 0 0
The activation of arylsulfatases R-HSA-1663150 8.880703e-01 0.052 0 0
Malate-aspartate shuttle R-HSA-9856872 8.880703e-01 0.052 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.880703e-01 0.052 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.880703e-01 0.052 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.880703e-01 0.052 0 0
Selenoamino acid metabolism R-HSA-2408522 8.894258e-01 0.051 0 0
G protein gated Potassium channels R-HSA-1296059 8.902178e-01 0.051 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.902178e-01 0.051 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.902178e-01 0.051 0 0
Tight junction interactions R-HSA-420029 8.902178e-01 0.051 0 0
Laminin interactions R-HSA-3000157 8.902178e-01 0.051 0 0
Hyaluronan degradation R-HSA-2160916 8.902178e-01 0.051 0 0
Translation of Structural Proteins R-HSA-9694635 8.902553e-01 0.050 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.906476e-01 0.050 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.918130e-01 0.050 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.936341e-01 0.049 0 0
Regulation of CDH1 Function R-HSA-9764561 8.951812e-01 0.048 0 0
PCP/CE pathway R-HSA-4086400 8.967618e-01 0.047 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.987262e-01 0.046 0 0
Metalloprotease DUBs R-HSA-5689901 9.003263e-01 0.046 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.003263e-01 0.046 0 0
Abacavir ADME R-HSA-2161522 9.003263e-01 0.046 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.008141e-01 0.045 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.008991e-01 0.045 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.008991e-01 0.045 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.008991e-01 0.045 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.008991e-01 0.045 0 0
Protein lipoylation R-HSA-9857492 9.008991e-01 0.045 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.008991e-01 0.045 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.008991e-01 0.045 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.008991e-01 0.045 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.008991e-01 0.045 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.008991e-01 0.045 0 0
DNA Damage Reversal R-HSA-73942 9.008991e-01 0.045 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.022617e-01 0.045 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.050837e-01 0.043 0 0
Platelet homeostasis R-HSA-418346 9.068934e-01 0.042 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.073525e-01 0.042 0 0
Regulation of beta-cell development R-HSA-186712 9.089221e-01 0.041 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.095606e-01 0.041 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.095606e-01 0.041 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.095606e-01 0.041 0 0
Triglyceride biosynthesis R-HSA-75109 9.095606e-01 0.041 0 0
Synthesis of PE R-HSA-1483213 9.095606e-01 0.041 0 0
MET promotes cell motility R-HSA-8875878 9.101608e-01 0.041 0 0
Elastic fibre formation R-HSA-1566948 9.101608e-01 0.041 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.101608e-01 0.041 0 0
Synthesis of DNA R-HSA-69239 9.118379e-01 0.040 0 0
Signaling by FGFR R-HSA-190236 9.120215e-01 0.040 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.120994e-01 0.040 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.122582e-01 0.040 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.122582e-01 0.040 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.122582e-01 0.040 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.122582e-01 0.040 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.122582e-01 0.040 0 0
Killing mechanisms R-HSA-9664420 9.122582e-01 0.040 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.122582e-01 0.040 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.122582e-01 0.040 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.122582e-01 0.040 0 0
Attachment and Entry R-HSA-9678110 9.122582e-01 0.040 0 0
Atorvastatin ADME R-HSA-9754706 9.122582e-01 0.040 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.143497e-01 0.039 0 0
GABA receptor activation R-HSA-977443 9.151815e-01 0.038 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.175179e-01 0.037 0 0
Pentose phosphate pathway R-HSA-71336 9.175179e-01 0.037 0 0
Inflammasomes R-HSA-622312 9.179883e-01 0.037 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.179883e-01 0.037 0 0
Hemostasis R-HSA-109582 9.197721e-01 0.036 0 0
Mitochondrial biogenesis R-HSA-1592230 9.209816e-01 0.036 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.210590e-01 0.036 0 0
MAP kinase activation R-HSA-450294 9.210590e-01 0.036 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.212924e-01 0.036 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.223158e-01 0.035 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.223158e-01 0.035 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.223158e-01 0.035 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.223158e-01 0.035 0 0
Glycine degradation R-HSA-6783984 9.223158e-01 0.035 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.223158e-01 0.035 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.223158e-01 0.035 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.223158e-01 0.035 0 0
Passive transport by Aquaporins R-HSA-432047 9.223158e-01 0.035 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.223158e-01 0.035 0 0
Galactose catabolism R-HSA-70370 9.223158e-01 0.035 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.223158e-01 0.035 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.223796e-01 0.035 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.225346e-01 0.035 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.243213e-01 0.034 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.243213e-01 0.034 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.256729e-01 0.034 0 0
mRNA Capping R-HSA-72086 9.256729e-01 0.034 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.256729e-01 0.034 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.256729e-01 0.034 0 0
Glucagon-type ligand receptors R-HSA-420092 9.256729e-01 0.034 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.256729e-01 0.034 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.265730e-01 0.033 0 0
Signaling by Insulin receptor R-HSA-74752 9.272890e-01 0.033 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.290903e-01 0.032 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.290903e-01 0.032 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.292905e-01 0.032 0 0
Maturation of spike protein R-HSA-9694548 9.306065e-01 0.031 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.306065e-01 0.031 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.312211e-01 0.031 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.312211e-01 0.031 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.312211e-01 0.031 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.312211e-01 0.031 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.312211e-01 0.031 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.312211e-01 0.031 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.312211e-01 0.031 0 0
Glycogen storage diseases R-HSA-3229121 9.312211e-01 0.031 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.312211e-01 0.031 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.312211e-01 0.031 0 0
Catecholamine biosynthesis R-HSA-209905 9.312211e-01 0.031 0 0
Choline catabolism R-HSA-6798163 9.312211e-01 0.031 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.312211e-01 0.031 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.326740e-01 0.030 0 0
Neurotransmitter clearance R-HSA-112311 9.326740e-01 0.030 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.327496e-01 0.030 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.364081e-01 0.029 0 0
HIV Transcription Initiation R-HSA-167161 9.364081e-01 0.029 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.364081e-01 0.029 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.364081e-01 0.029 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.390473e-01 0.027 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.390473e-01 0.027 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.390473e-01 0.027 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.391060e-01 0.027 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.391060e-01 0.027 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.391060e-01 0.027 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.391060e-01 0.027 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.391060e-01 0.027 0 0
Platelet sensitization by LDL R-HSA-432142 9.391060e-01 0.027 0 0
Nephron development R-HSA-9831926 9.391060e-01 0.027 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.391060e-01 0.027 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.399127e-01 0.027 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.399127e-01 0.027 0 0
UCH proteinases R-HSA-5689603 9.410428e-01 0.026 0 0
Cellular response to hypoxia R-HSA-1234174 9.411138e-01 0.026 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.417584e-01 0.026 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.418983e-01 0.026 0 0
Nucleotide Excision Repair R-HSA-5696398 9.451307e-01 0.025 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.455536e-01 0.024 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.459637e-01 0.024 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.460874e-01 0.024 0 0
Pyrimidine biosynthesis R-HSA-500753 9.460874e-01 0.024 0 0
Translesion Synthesis by POLH R-HSA-110320 9.460874e-01 0.024 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.460874e-01 0.024 0 0
Other interleukin signaling R-HSA-449836 9.460874e-01 0.024 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.466887e-01 0.024 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.466887e-01 0.024 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.501144e-01 0.022 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.512451e-01 0.022 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.512451e-01 0.022 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.522687e-01 0.021 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.522687e-01 0.021 0 0
Glycogen synthesis R-HSA-3322077 9.522687e-01 0.021 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.522687e-01 0.021 0 0
Negative regulation of MET activity R-HSA-6807004 9.522687e-01 0.021 0 0
Pregnenolone biosynthesis R-HSA-196108 9.522687e-01 0.021 0 0
Signal transduction by L1 R-HSA-445144 9.522687e-01 0.021 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.522960e-01 0.021 0 0
Cellular response to chemical stress R-HSA-9711123 9.531283e-01 0.021 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.547793e-01 0.020 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.549011e-01 0.020 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.549011e-01 0.020 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.554048e-01 0.020 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.554048e-01 0.020 0 0
Signaling by MET R-HSA-6806834 9.555923e-01 0.020 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.577417e-01 0.019 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.577417e-01 0.019 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.577417e-01 0.019 0 0
ERK/MAPK targets R-HSA-198753 9.577417e-01 0.019 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.577417e-01 0.019 0 0
Abacavir metabolism R-HSA-2161541 9.577417e-01 0.019 0 0
Dual incision in TC-NER R-HSA-6782135 9.586225e-01 0.018 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.592446e-01 0.018 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.592446e-01 0.018 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.592446e-01 0.018 0 0
Dual Incision in GG-NER R-HSA-5696400 9.592464e-01 0.018 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.592464e-01 0.018 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.592464e-01 0.018 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.592464e-01 0.018 0 0
Interleukin-17 signaling R-HSA-448424 9.596743e-01 0.018 0 0
IRE1alpha activates chaperones R-HSA-381070 9.612853e-01 0.017 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.625873e-01 0.017 0 0
Ribavirin ADME R-HSA-9755088 9.625873e-01 0.017 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.625873e-01 0.017 0 0
Eicosanoids R-HSA-211979 9.625873e-01 0.017 0 0
Assembly Of The HIV Virion R-HSA-175474 9.625873e-01 0.017 0 0
Regulation of Apoptosis R-HSA-169911 9.631886e-01 0.016 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.631886e-01 0.016 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.631886e-01 0.016 0 0
PERK regulates gene expression R-HSA-381042 9.631886e-01 0.016 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.638769e-01 0.016 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.645428e-01 0.016 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.649551e-01 0.015 0 0
Gluconeogenesis R-HSA-70263 9.660112e-01 0.015 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.667628e-01 0.015 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.668776e-01 0.015 0 0
LDL clearance R-HSA-8964038 9.668776e-01 0.015 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.668776e-01 0.015 0 0
Mitochondrial protein degradation R-HSA-9837999 9.685930e-01 0.014 0 0
DNA Damage Bypass R-HSA-73893 9.689827e-01 0.014 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.700016e-01 0.013 0 0
Degradation of DVL R-HSA-4641258 9.700016e-01 0.013 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.700016e-01 0.013 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.700016e-01 0.013 0 0
NCAM1 interactions R-HSA-419037 9.700016e-01 0.013 0 0
Viral Infection Pathways R-HSA-9824446 9.703016e-01 0.013 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.706762e-01 0.013 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.706762e-01 0.013 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.706762e-01 0.013 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.706762e-01 0.013 0 0
Formation of the ureteric bud R-HSA-9830674 9.706762e-01 0.013 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.706762e-01 0.013 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.706762e-01 0.013 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.706762e-01 0.013 0 0
Interleukin-20 family signaling R-HSA-8854691 9.706762e-01 0.013 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.734503e-01 0.012 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.734503e-01 0.012 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.740393e-01 0.011 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.740393e-01 0.011 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.740393e-01 0.011 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.740393e-01 0.011 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.740393e-01 0.011 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.740393e-01 0.011 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.742042e-01 0.011 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.742042e-01 0.011 0 0
Interferon alpha/beta signaling R-HSA-909733 9.743613e-01 0.011 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.755903e-01 0.011 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.770168e-01 0.010 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.770168e-01 0.010 0 0
Fertilization R-HSA-1187000 9.770168e-01 0.010 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.770168e-01 0.010 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.770168e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.777869e-01 0.010 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.779928e-01 0.010 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.779928e-01 0.010 0 0
Diseases of Immune System R-HSA-5260271 9.779928e-01 0.010 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.785836e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.789475e-01 0.009 0 0
MET activates PTK2 signaling R-HSA-8874081 9.796530e-01 0.009 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.796530e-01 0.009 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.796530e-01 0.009 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.796530e-01 0.009 0 0
Sphingolipid catabolism R-HSA-9845614 9.796530e-01 0.009 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.801654e-01 0.009 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.801654e-01 0.009 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.806915e-01 0.008 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.819870e-01 0.008 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.819870e-01 0.008 0 0
Insulin processing R-HSA-264876 9.819870e-01 0.008 0 0
Signaling by BMP R-HSA-201451 9.819870e-01 0.008 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.822485e-01 0.008 0 0
G alpha (z) signalling events R-HSA-418597 9.822485e-01 0.008 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.828427e-01 0.008 0 0
tRNA processing R-HSA-72306 9.829011e-01 0.007 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.829125e-01 0.007 0 0
Parasite infection R-HSA-9664407 9.829125e-01 0.007 0 0
Leishmania phagocytosis R-HSA-9664417 9.829125e-01 0.007 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.838480e-01 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.838480e-01 0.007 0 0
Activation of GABAB receptors R-HSA-991365 9.839039e-01 0.007 0 0
GABA B receptor activation R-HSA-977444 9.839039e-01 0.007 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.839039e-01 0.007 0 0
Prednisone ADME R-HSA-9757110 9.840534e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.851189e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.853090e-01 0.006 0 0
Defensins R-HSA-1461973 9.855066e-01 0.006 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.855066e-01 0.006 0 0
Thyroxine biosynthesis R-HSA-209968 9.858828e-01 0.006 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.858828e-01 0.006 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.858828e-01 0.006 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.858966e-01 0.006 0 0
Retinoid metabolism and transport R-HSA-975634 9.863926e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.868940e-01 0.006 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.869536e-01 0.006 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.875024e-01 0.005 0 0
Mucopolysaccharidoses R-HSA-2206281 9.875024e-01 0.005 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.878596e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.878596e-01 0.005 0 0
Somitogenesis R-HSA-9824272 9.882594e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.885537e-01 0.005 0 0
Cargo concentration in the ER R-HSA-5694530 9.889363e-01 0.005 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.889363e-01 0.005 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.889363e-01 0.005 0 0
tRNA Aminoacylation R-HSA-379724 9.889696e-01 0.005 0 0
Platelet degranulation R-HSA-114608 9.894344e-01 0.005 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.894374e-01 0.005 0 0
Parasitic Infection Pathways R-HSA-9824443 9.895252e-01 0.005 0 0
Leishmania infection R-HSA-9658195 9.895252e-01 0.005 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.899814e-01 0.004 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.902058e-01 0.004 0 0
HS-GAG degradation R-HSA-2024096 9.902058e-01 0.004 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.904685e-01 0.004 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.904998e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.904998e-01 0.004 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.909035e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.910751e-01 0.004 0 0
Recycling of bile acids and salts R-HSA-159418 9.913297e-01 0.004 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.913297e-01 0.004 0 0
GPCR downstream signalling R-HSA-388396 9.915518e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.923205e-01 0.003 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.923246e-01 0.003 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.923246e-01 0.003 0 0
CS/DS degradation R-HSA-2024101 9.923246e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.927289e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.927289e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.930981e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.932055e-01 0.003 0 0
eNOS activation R-HSA-203615 9.932055e-01 0.003 0 0
Signaling by NOTCH2 R-HSA-1980145 9.932055e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.932055e-01 0.003 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.937984e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.937984e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.939341e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.939853e-01 0.003 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.939853e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.939853e-01 0.003 0 0
Metabolism of steroid hormones R-HSA-196071 9.944130e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.944130e-01 0.002 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.944289e-01 0.002 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.944697e-01 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 9.946756e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.946756e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.949964e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.952056e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.952753e-01 0.002 0 0
Degradation of AXIN R-HSA-4641257 9.952868e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.952868e-01 0.002 0 0
Lysine catabolism R-HSA-71064 9.952868e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.953099e-01 0.002 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.955071e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.955646e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.958278e-01 0.002 0 0
Purine salvage R-HSA-74217 9.958278e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.958444e-01 0.002 0 0
Signaling by NOTCH3 R-HSA-9012852 9.959665e-01 0.002 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.961780e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.962369e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.962369e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.962369e-01 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.963067e-01 0.002 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.963067e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.963067e-01 0.002 0 0
RAS processing R-HSA-9648002 9.963067e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.964962e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.964962e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.965932e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.966478e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.967307e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.967512e-01 0.001 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.971061e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.971061e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.973852e-01 0.001 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.974383e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.974513e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.974760e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.978214e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.978214e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.978971e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.980107e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.980703e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.981146e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.981342e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.981342e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.982234e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.982234e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.983099e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.984274e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.984274e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.984853e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.985905e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.986080e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.989094e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.989105e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.989853e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.989891e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.989927e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.990242e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.990347e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.990347e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.990409e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.990869e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.992175e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.993280e-01 0.000 0 0
Neddylation R-HSA-8951664 9.994307e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994387e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.994535e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.994976e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.995359e-01 0.000 0 0
Digestion R-HSA-8935690 9.995892e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.996750e-01 0.000 0 0
Translation R-HSA-72766 9.996982e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.997152e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.997156e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.997423e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.997479e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.997625e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997769e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997862e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997889e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.998252e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998267e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998334e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998441e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998453e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998530e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.998631e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998979e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999051e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999054e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999063e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999116e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999174e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999236e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999257e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999418e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999515e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999565e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999581e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999597e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999720e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999746e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999759e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999847e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999866e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999893e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999914e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999914e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999917e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999960e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999965e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999968e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999969e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999975e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999976e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999979e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999987e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999988e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999994e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Disease R-HSA-1643685 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 6.314171e-12 11.200 0 0
HSF1-dependent transactivation R-HSA-3371571 1.430922e-11 10.844 0 0
Attenuation phase R-HSA-3371568 1.299616e-11 10.886 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.956873e-10 9.225 0 0
Cellular responses to stimuli R-HSA-8953897 3.578678e-08 7.446 0 0
HSF1 activation R-HSA-3371511 4.750708e-08 7.323 0 0
Cellular responses to stress R-HSA-2262752 9.558031e-08 7.020 0 0
Axon guidance R-HSA-422475 2.362110e-07 6.627 1 0
Apoptotic execution phase R-HSA-75153 4.070593e-07 6.390 0 0
Nervous system development R-HSA-9675108 4.065147e-07 6.391 1 0
Signaling by ROBO receptors R-HSA-376176 4.811796e-07 6.318 1 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.124360e-07 6.147 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.124360e-07 6.147 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.447257e-06 5.839 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.447257e-06 5.839 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.591891e-06 5.445 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.968223e-06 5.157 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.827111e-06 5.166 0 0
Cell Cycle R-HSA-1640170 1.010802e-05 4.995 0 0
M Phase R-HSA-68886 1.427707e-05 4.845 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.887098e-05 4.724 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.985409e-05 4.702 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.705787e-05 4.431 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.047290e-05 4.393 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.975903e-05 4.224 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.975903e-05 4.224 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.822022e-05 4.235 0 0
Mitotic Prometaphase R-HSA-68877 6.988480e-05 4.156 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.908200e-05 4.102 0 0
Death Receptor Signaling R-HSA-73887 7.834017e-05 4.106 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.192455e-05 4.037 0 0
Cell Cycle, Mitotic R-HSA-69278 1.052586e-04 3.978 0 0
Peptide chain elongation R-HSA-156902 1.093142e-04 3.961 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.297118e-04 3.887 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.423571e-04 3.847 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.768474e-04 3.752 0 0
Signal Transduction R-HSA-162582 1.841660e-04 3.735 1 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.160549e-04 3.665 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.564296e-04 3.591 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.590211e-04 3.587 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.436330e-04 3.613 0 0
Cell Cycle Checkpoints R-HSA-69620 2.836207e-04 3.547 0 0
Translation initiation complex formation R-HSA-72649 3.364255e-04 3.473 0 0
Mitotic Anaphase R-HSA-68882 3.352045e-04 3.475 0 0
G alpha (12/13) signalling events R-HSA-416482 3.368541e-04 3.473 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.875089e-04 3.412 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.648849e-04 3.438 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.875089e-04 3.412 0 0
Signaling by ALK in cancer R-HSA-9700206 3.875089e-04 3.412 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.738395e-04 3.427 0 0
Apoptosis R-HSA-109581 3.739735e-04 3.427 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.117083e-04 3.385 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.587071e-04 3.338 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.587071e-04 3.338 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.782581e-04 3.320 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.782581e-04 3.320 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.636193e-04 3.334 0 0
NRAGE signals death through JNK R-HSA-193648 4.782581e-04 3.320 0 0
Influenza Infection R-HSA-168255 5.350662e-04 3.272 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.988111e-04 3.223 0 0
Regulation of TP53 Activity R-HSA-5633007 6.082624e-04 3.216 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.422937e-04 3.192 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.379948e-04 3.132 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.733082e-04 3.112 0 0
Chromatin modifying enzymes R-HSA-3247509 7.901019e-04 3.102 0 0
Chromatin organization R-HSA-4839726 7.902689e-04 3.102 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.850611e-04 3.053 0 0
Eukaryotic Translation Termination R-HSA-72764 8.887160e-04 3.051 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 9.381381e-04 3.028 0 0
Signaling by ERBB2 R-HSA-1227986 9.209983e-04 3.036 0 0
p75NTR signals via NF-kB R-HSA-193639 9.381381e-04 3.028 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.381381e-04 3.028 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.997998e-04 3.000 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.021808e-03 2.991 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.021808e-03 2.991 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.108661e-03 2.955 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.077858e-03 2.967 0 0
NF-kB is activated and signals survival R-HSA-209560 1.077858e-03 2.967 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.108661e-03 2.955 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.108661e-03 2.955 0 0
Membrane Trafficking R-HSA-199991 1.268240e-03 2.897 0 0
Programmed Cell Death R-HSA-5357801 1.497827e-03 2.825 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.595955e-03 2.797 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.628818e-03 2.788 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.749776e-03 2.757 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.699400e-03 2.770 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.701309e-03 2.769 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.776510e-03 2.750 0 0
Selenocysteine synthesis R-HSA-2408557 1.784132e-03 2.749 0 0
mRNA 3'-end processing R-HSA-72187 1.785127e-03 2.748 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.891355e-03 2.723 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.949869e-03 2.710 0 0
Mitotic Prophase R-HSA-68875 2.027954e-03 2.693 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.072332e-03 2.684 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.173611e-03 2.663 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.125301e-03 2.673 0 0
Viral mRNA Translation R-HSA-192823 2.217753e-03 2.654 0 0
Signaling by TGFB family members R-HSA-9006936 2.200472e-03 2.657 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.278633e-03 2.642 0 0
Signaling by Hippo R-HSA-2028269 2.323769e-03 2.634 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.544601e-03 2.594 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.544601e-03 2.594 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.544601e-03 2.594 0 0
Josephin domain DUBs R-HSA-5689877 2.544601e-03 2.594 0 0
Metabolism of RNA R-HSA-8953854 2.612749e-03 2.583 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.630308e-03 2.580 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.302897e-03 2.481 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 3.696698e-03 2.432 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.512646e-03 2.454 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.514568e-03 2.454 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.514568e-03 2.454 0 0
Semaphorin interactions R-HSA-373755 3.514568e-03 2.454 0 0
Interleukin-12 signaling R-HSA-9020591 3.448122e-03 2.462 0 0
Ribosome-associated quality control R-HSA-9948299 3.738105e-03 2.427 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.907059e-03 2.408 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.907059e-03 2.408 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.978432e-03 2.400 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.978432e-03 2.400 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.098304e-03 2.387 0 0
Regulation of PTEN localization R-HSA-8948747 4.098304e-03 2.387 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.150672e-03 2.382 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.370528e-03 2.359 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.470847e-03 2.350 0 0
Glycogen metabolism R-HSA-8982491 4.150672e-03 2.382 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.504119e-03 2.346 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.757579e-03 2.323 0 0
Cell-Cell communication R-HSA-1500931 4.759875e-03 2.322 0 0
Negative regulation of MET activity R-HSA-6807004 4.959604e-03 2.305 0 0
Activation of RAC1 R-HSA-428540 5.062458e-03 2.296 1 1
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.062458e-03 2.296 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.062458e-03 2.296 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.531219e-03 2.257 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.531219e-03 2.257 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.158730e-03 2.287 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.354282e-03 2.271 0 0
Negative regulation of FLT3 R-HSA-9706369 5.223401e-03 2.282 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.789343e-03 2.237 0 0
Calmodulin induced events R-HSA-111933 5.823534e-03 2.235 0 0
CaM pathway R-HSA-111997 5.823534e-03 2.235 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.823534e-03 2.235 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.315347e-03 2.200 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.320993e-03 2.199 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.366242e-03 2.196 0 0
Cellular response to starvation R-HSA-9711097 6.117851e-03 2.213 0 0
Ca-dependent events R-HSA-111996 6.637912e-03 2.178 0 0
Cellular Senescence R-HSA-2559583 6.214237e-03 2.207 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.074118e-03 2.217 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.216469e-03 2.206 0 0
Interleukin-12 family signaling R-HSA-447115 6.172894e-03 2.210 0 0
Centrosome maturation R-HSA-380287 6.730735e-03 2.172 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.848430e-03 2.164 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.848430e-03 2.164 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.851692e-03 2.164 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.920391e-03 2.160 0 0
mRNA Splicing R-HSA-72172 7.043790e-03 2.152 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.268715e-03 2.139 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.483635e-03 2.126 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.537888e-03 2.069 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.537888e-03 2.069 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.537888e-03 2.069 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.537888e-03 2.069 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.193625e-03 2.087 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.193625e-03 2.087 0 0
Signaling by EGFR R-HSA-177929 7.736085e-03 2.111 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.193625e-03 2.087 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.972042e-03 2.098 0 0
Gap junction degradation R-HSA-190873 8.638711e-03 2.064 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.638711e-03 2.064 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.651946e-03 2.015 0 0
Striated Muscle Contraction R-HSA-390522 9.651946e-03 2.015 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.651946e-03 2.015 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.009223e-03 2.045 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.437878e-03 2.025 0 0
Separation of Sister Chromatids R-HSA-2467813 9.446845e-03 2.025 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.761227e-03 2.010 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.237548e-03 2.034 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.863362e-03 2.052 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.329531e-03 2.030 0 0
Maturation of protein E R-HSA-9694493 9.955729e-03 2.002 0 0
Maturation of protein E R-HSA-9683683 9.955729e-03 2.002 0 0
DAG and IP3 signaling R-HSA-1489509 1.017454e-02 1.992 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.030962e-02 1.987 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.062932e-02 1.973 0 0
Ephrin signaling R-HSA-3928664 1.072024e-02 1.970 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.072024e-02 1.970 0 0
EPH-Ephrin signaling R-HSA-2682334 1.115898e-02 1.952 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.145036e-02 1.941 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.146821e-02 1.941 0 0
Late endosomal microautophagy R-HSA-9615710 1.156732e-02 1.937 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.171893e-02 1.931 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.171893e-02 1.931 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.171893e-02 1.931 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.171893e-02 1.931 0 0
Pexophagy R-HSA-9664873 1.186838e-02 1.926 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.370008e-02 1.863 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.253357e-02 1.902 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.253357e-02 1.902 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.253357e-02 1.902 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.253357e-02 1.902 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.328983e-02 1.876 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.253357e-02 1.902 0 0
Cell junction organization R-HSA-446728 1.275531e-02 1.894 0 0
Glycolysis R-HSA-70171 1.304605e-02 1.885 0 0
FLT3 Signaling R-HSA-9607240 1.244709e-02 1.905 0 0
PLC beta mediated events R-HSA-112043 1.403344e-02 1.853 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.409105e-02 1.851 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.472791e-02 1.832 0 0
DCC mediated attractive signaling R-HSA-418885 1.489711e-02 1.827 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.489711e-02 1.827 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.489711e-02 1.827 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.489711e-02 1.827 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.494591e-02 1.825 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.495632e-02 1.825 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.501945e-02 1.823 0 0
Developmental Biology R-HSA-1266738 1.573341e-02 1.803 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.583280e-02 1.800 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.583280e-02 1.800 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.598873e-02 1.796 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.618021e-02 1.791 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.753097e-02 1.756 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.764527e-02 1.753 0 0
Opioid Signalling R-HSA-111885 1.824476e-02 1.739 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.845476e-02 1.734 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.853021e-02 1.732 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.954266e-02 1.709 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.073814e-02 1.683 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.272630e-02 1.643 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.153779e-02 1.667 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.098013e-02 1.678 0 0
Deubiquitination R-HSA-5688426 2.080138e-02 1.682 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.269205e-02 1.644 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.269205e-02 1.644 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.073814e-02 1.683 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.295261e-02 1.639 0 0
Signaling by VEGF R-HSA-194138 2.160884e-02 1.665 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.008423e-02 1.697 0 0
MAPK family signaling cascades R-HSA-5683057 2.148608e-02 1.668 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.295261e-02 1.639 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.203348e-02 1.657 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.336488e-02 1.631 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.366026e-02 1.626 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.369830e-02 1.625 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.395862e-02 1.621 0 0
Post NMDA receptor activation events R-HSA-438064 2.401183e-02 1.620 0 0
G2/M Transition R-HSA-69275 2.447869e-02 1.611 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.480434e-02 1.605 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.480745e-02 1.605 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.481513e-02 1.605 0 0
G2/M Checkpoints R-HSA-69481 2.483636e-02 1.605 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.552106e-02 1.593 0 0
Signaling by NOTCH4 R-HSA-9013694 2.552106e-02 1.593 0 0
Autophagy R-HSA-9612973 2.585275e-02 1.587 0 0
G-protein mediated events R-HSA-112040 2.611476e-02 1.583 0 0
Selective autophagy R-HSA-9663891 2.612151e-02 1.583 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.620255e-02 1.582 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.620255e-02 1.582 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.646181e-02 1.577 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.737034e-02 1.563 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.790382e-02 1.554 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.790382e-02 1.554 0 0
Type I hemidesmosome assembly R-HSA-446107 2.805963e-02 1.552 0 0
Formation of annular gap junctions R-HSA-196025 2.805963e-02 1.552 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.805963e-02 1.552 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.805963e-02 1.552 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.805963e-02 1.552 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.834954e-02 1.547 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.834954e-02 1.547 0 0
Signaling by NOTCH2 R-HSA-1980145 2.834954e-02 1.547 0 0
Nuclear import of Rev protein R-HSA-180746 2.834954e-02 1.547 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.656791e-02 1.437 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.656791e-02 1.437 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.270206e-02 1.485 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.351224e-02 1.475 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.060384e-02 1.514 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.516969e-02 1.454 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.653674e-02 1.437 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.653674e-02 1.437 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.653674e-02 1.437 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.270206e-02 1.485 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.062255e-02 1.514 0 0
Signaling by NOTCH1 R-HSA-1980143 3.052953e-02 1.515 0 0
NrCAM interactions R-HSA-447038 3.656791e-02 1.437 0 0
Signaling by PTK6 R-HSA-8848021 3.549560e-02 1.450 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.549560e-02 1.450 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.445558e-02 1.463 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.304136e-02 1.481 0 0
Signaling by NOTCH3 R-HSA-9012852 3.289838e-02 1.483 0 0
FLT3 signaling in disease R-HSA-9682385 3.654576e-02 1.437 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.673862e-02 1.435 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.673862e-02 1.435 0 0
Lipophagy R-HSA-9613354 3.673862e-02 1.435 0 0
ALK mutants bind TKIs R-HSA-9700645 3.673862e-02 1.435 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.685477e-02 1.434 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.702831e-02 1.431 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.702831e-02 1.431 0 0
MTOR signalling R-HSA-165159 3.702831e-02 1.431 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.783598e-02 1.422 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.783598e-02 1.422 0 0
Cellular response to chemical stress R-HSA-9711123 3.815143e-02 1.418 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 3.883256e-02 1.411 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.883256e-02 1.411 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.883256e-02 1.411 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.883256e-02 1.411 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.883256e-02 1.411 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.883256e-02 1.411 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.883256e-02 1.411 0 0
Regulation of signaling by CBL R-HSA-912631 3.980266e-02 1.400 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.980266e-02 1.400 0 0
Regulation of CDH1 Function R-HSA-9764561 4.003009e-02 1.398 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.012346e-02 1.397 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.012346e-02 1.397 0 0
EGFR downregulation R-HSA-182971 4.017480e-02 1.396 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.017480e-02 1.396 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.017480e-02 1.396 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.069892e-02 1.295 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.069892e-02 1.295 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.069892e-02 1.295 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.848748e-02 1.314 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.088280e-02 1.388 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.255438e-02 1.371 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.957636e-02 1.305 0 0
DNA Double Strand Break Response R-HSA-5693606 5.054283e-02 1.296 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.933784e-02 1.307 0 0
TGFBR3 expression R-HSA-9839394 4.372919e-02 1.359 0 0
Nephrin family interactions R-HSA-373753 4.679437e-02 1.330 0 0
Metalloprotease DUBs R-HSA-5689901 5.018342e-02 1.299 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.372919e-02 1.359 0 0
Signaling by WNT R-HSA-195721 4.628893e-02 1.335 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.119637e-02 1.385 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.054283e-02 1.296 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.069892e-02 1.295 0 0
Macroautophagy R-HSA-1632852 4.154180e-02 1.382 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.528033e-02 1.344 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.528033e-02 1.344 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.138224e-02 1.383 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.848748e-02 1.314 0 0
Glycogen synthesis R-HSA-3322077 4.679437e-02 1.330 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.467899e-02 1.350 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.017305e-02 1.300 0 0
G-protein beta:gamma signalling R-HSA-397795 5.155468e-02 1.288 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.155468e-02 1.288 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.155468e-02 1.288 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.165785e-02 1.287 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.236513e-02 1.281 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.265218e-02 1.279 0 0
Kinesins R-HSA-983189 5.265218e-02 1.279 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.450107e-02 1.264 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.544789e-02 1.256 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.589201e-02 1.253 0 0
Glucose metabolism R-HSA-70326 5.617308e-02 1.250 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.627601e-02 1.250 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.627601e-02 1.250 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.627601e-02 1.250 0 0
Signaling by RAS mutants R-HSA-6802949 5.627601e-02 1.250 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.627601e-02 1.250 0 0
Aggrephagy R-HSA-9646399 5.748646e-02 1.240 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.748646e-02 1.240 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.794998e-02 1.237 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.794998e-02 1.237 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.794998e-02 1.237 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.822753e-02 1.235 0 0
Homology Directed Repair R-HSA-5693538 5.965336e-02 1.224 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.105551e-02 1.214 0 0
ESR-mediated signaling R-HSA-8939211 6.150480e-02 1.211 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.215588e-02 1.207 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.242131e-02 1.205 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.293075e-02 1.201 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.293075e-02 1.201 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.293075e-02 1.201 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.436128e-02 1.191 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.436128e-02 1.191 0 0
Dual Incision in GG-NER R-HSA-5696400 6.482544e-02 1.188 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.482544e-02 1.188 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.482544e-02 1.188 0 0
Mitophagy R-HSA-5205647 6.482544e-02 1.188 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.574480e-02 1.182 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.707687e-02 1.173 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.707687e-02 1.173 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.739041e-02 1.171 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.807356e-02 1.167 0 0
Disorders of Developmental Biology R-HSA-9675151 6.807356e-02 1.167 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.807356e-02 1.167 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.807356e-02 1.167 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.807356e-02 1.167 0 0
Ub-specific processing proteases R-HSA-5689880 6.828265e-02 1.166 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 8.553786e-02 1.068 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.553786e-02 1.068 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.100972e-02 1.149 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.509890e-02 1.070 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.928552e-02 1.101 0 0
PKA activation R-HSA-163615 9.142109e-02 1.039 0 0
PKA activation in glucagon signalling R-HSA-164378 9.142109e-02 1.039 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.196293e-02 1.086 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.196293e-02 1.086 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.300236e-02 1.137 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.037198e-02 1.153 0 0
Neutrophil degranulation R-HSA-6798695 9.071364e-02 1.042 0 0
MAP2K and MAPK activation R-HSA-5674135 7.037198e-02 1.153 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.112440e-02 1.040 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.100972e-02 1.149 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.509890e-02 1.070 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.003261e-02 1.097 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.686332e-02 1.061 0 0
Adipogenesis R-HSA-9843745 8.699415e-02 1.061 0 0
Repression of WNT target genes R-HSA-4641265 8.509890e-02 1.070 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.509890e-02 1.070 0 0
Signaling by MET R-HSA-6806834 7.582726e-02 1.120 0 0
TNF signaling R-HSA-75893 7.109596e-02 1.148 0 0
Rab regulation of trafficking R-HSA-9007101 8.941761e-02 1.049 0 0
Vesicle-mediated transport R-HSA-5653656 7.277100e-02 1.138 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.126508e-02 1.090 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.874847e-02 1.104 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.100972e-02 1.149 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.836628e-02 1.054 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.960367e-02 1.048 0 0
Muscle contraction R-HSA-397014 8.924553e-02 1.049 0 0
Signaling by ERBB4 R-HSA-1236394 8.637304e-02 1.064 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.553786e-02 1.068 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.208575e-02 1.142 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.509890e-02 1.070 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.509890e-02 1.070 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.743695e-02 1.111 0 0
Specification of primordial germ cells R-HSA-9827857 7.928552e-02 1.101 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.509890e-02 1.070 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.509890e-02 1.070 0 0
Glycogen storage diseases R-HSA-3229121 7.928552e-02 1.101 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.255376e-02 1.034 0 0
Neurodegenerative Diseases R-HSA-8863678 9.255376e-02 1.034 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.255376e-02 1.034 0 0
RMTs methylate histone arginines R-HSA-3214858 9.281883e-02 1.032 0 0
Selenoamino acid metabolism R-HSA-2408522 9.344335e-02 1.029 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.451422e-02 1.025 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 9.451422e-02 1.025 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 9.451422e-02 1.025 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.574979e-02 1.019 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.718407e-02 1.012 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.757308e-02 1.011 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.767010e-02 1.010 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 9.772973e-02 1.010 0 0
Defective OGG1 Localization R-HSA-9657050 9.772973e-02 1.010 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.772973e-02 1.010 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.840807e-02 1.007 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.857420e-02 1.006 0 0
rRNA processing R-HSA-72312 9.934430e-02 1.003 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.004357e-01 0.998 0 0
Formation of axial mesoderm R-HSA-9796292 1.004357e-01 0.998 0 0
Interleukin-6 signaling R-HSA-1059683 1.004357e-01 0.998 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.004357e-01 0.998 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.004357e-01 0.998 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.004357e-01 0.998 0 0
Meiotic synapsis R-HSA-1221632 1.036012e-01 0.985 0 0
Smooth Muscle Contraction R-HSA-445355 1.036012e-01 0.985 0 0
Translesion Synthesis by POLH R-HSA-110320 1.044528e-01 0.981 0 0
MET receptor recycling R-HSA-8875656 1.058886e-01 0.975 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.058886e-01 0.975 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.058886e-01 0.975 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.064811e-01 0.973 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.064811e-01 0.973 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.275159e-01 0.894 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.275159e-01 0.894 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.627178e-01 0.789 0 0
Activation of AKT2 R-HSA-165158 1.627178e-01 0.789 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.627178e-01 0.789 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.627178e-01 0.789 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.627178e-01 0.789 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.627178e-01 0.789 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.514035e-01 0.820 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.514035e-01 0.820 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.345502e-01 0.871 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.345502e-01 0.871 0 0
Translesion synthesis by POLI R-HSA-5656121 1.531525e-01 0.815 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.531525e-01 0.815 0 0
Phosphorylation of the APC/C R-HSA-176412 1.531525e-01 0.815 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.485436e-01 0.828 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.485436e-01 0.828 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.284492e-01 0.891 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.284492e-01 0.891 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.555792e-01 0.808 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.285254e-01 0.891 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.203828e-01 0.919 0 0
HDACs deacetylate histones R-HSA-3214815 1.203828e-01 0.919 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.293039e-01 0.888 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.481751e-01 0.829 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.596935e-01 0.797 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.264824e-01 0.898 0 0
Formation of definitive endoderm R-HSA-9823730 1.183459e-01 0.927 0 0
Integrin signaling R-HSA-354192 1.115371e-01 0.953 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.162503e-01 0.935 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.189929e-01 0.924 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.555792e-01 0.808 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.215841e-01 0.915 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.309479e-01 0.883 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.330586e-01 0.876 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.617062e-01 0.791 0 0
DNA Damage Bypass R-HSA-73893 1.384491e-01 0.859 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.514035e-01 0.820 0 0
PCP/CE pathway R-HSA-4086400 1.125936e-01 0.948 0 0
Translesion synthesis by REV1 R-HSA-110312 1.345502e-01 0.871 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.531525e-01 0.815 0 0
Recycling pathway of L1 R-HSA-437239 1.189929e-01 0.924 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.158174e-01 0.936 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.555792e-01 0.808 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.341506e-01 0.872 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.279174e-01 0.893 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.361996e-01 0.866 0 0
Myogenesis R-HSA-525793 1.158174e-01 0.936 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.345502e-01 0.871 0 0
Ca2+ pathway R-HSA-4086398 1.366484e-01 0.864 0 0
Oncogene Induced Senescence R-HSA-2559585 1.462417e-01 0.835 0 0
NGF-stimulated transcription R-HSA-9031628 1.285254e-01 0.891 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.627178e-01 0.789 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.279174e-01 0.893 0 0
Unwinding of DNA R-HSA-176974 1.279174e-01 0.893 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.531525e-01 0.815 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.417132e-01 0.849 0 0
DARPP-32 events R-HSA-180024 1.555792e-01 0.808 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.341506e-01 0.872 0 0
Metabolism of non-coding RNA R-HSA-194441 1.581091e-01 0.801 0 0
snRNP Assembly R-HSA-191859 1.581091e-01 0.801 0 0
RSV-host interactions R-HSA-9833110 1.497149e-01 0.825 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.514035e-01 0.820 0 0
Cell-cell junction organization R-HSA-421270 1.416988e-01 0.849 0 0
Cellular response to hypoxia R-HSA-1234174 1.378908e-01 0.860 0 0
Adherens junctions interactions R-HSA-418990 1.530627e-01 0.815 0 0
L1CAM interactions R-HSA-373760 1.300618e-01 0.886 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.158174e-01 0.936 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.279174e-01 0.893 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.098601e-01 0.959 0 0
Signaling by TGFBR3 R-HSA-9839373 1.098601e-01 0.959 0 0
Pyruvate metabolism R-HSA-70268 1.257590e-01 0.900 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.088476e-01 0.963 0 0
Diseases of DNA repair R-HSA-9675135 1.098601e-01 0.959 0 0
Cilium Assembly R-HSA-5617833 1.393771e-01 0.856 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.514035e-01 0.820 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.330586e-01 0.876 0 0
RET signaling R-HSA-8853659 1.588286e-01 0.799 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.385704e-01 0.858 0 0
Sensory processing of sound R-HSA-9659379 1.198059e-01 0.922 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.485436e-01 0.828 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.284492e-01 0.891 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.169473e-01 0.932 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.462417e-01 0.835 0 0
PKR-mediated signaling R-HSA-9833482 1.272777e-01 0.895 0 0
Assembly Of The HIV Virion R-HSA-175474 1.485436e-01 0.828 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.162503e-01 0.935 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.264824e-01 0.898 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.293039e-01 0.888 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.627178e-01 0.789 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.485436e-01 0.828 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.218328e-01 0.914 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.531525e-01 0.815 0 0
Regulation of BACH1 activity R-HSA-9708530 1.531525e-01 0.815 0 0
Notch-HLH transcription pathway R-HSA-350054 1.647489e-01 0.783 0 0
mTORC1-mediated signalling R-HSA-166208 1.647489e-01 0.783 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.657609e-01 0.781 0 0
Regulated Necrosis R-HSA-5218859 1.657609e-01 0.781 0 0
Meiosis R-HSA-1500620 1.684075e-01 0.774 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.700137e-01 0.770 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.700137e-01 0.770 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.704619e-01 0.768 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.704619e-01 0.768 0 0
Netrin-1 signaling R-HSA-373752 1.717844e-01 0.765 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.726561e-01 0.763 0 0
Translesion synthesis by POLK R-HSA-5655862 1.726561e-01 0.763 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.726561e-01 0.763 0 0
Protein folding R-HSA-391251 1.731101e-01 0.762 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.761238e-01 0.754 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.761238e-01 0.754 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.761238e-01 0.754 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.761238e-01 0.754 0 0
Signaling by APC mutants R-HSA-4839744 1.761238e-01 0.754 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.772801e-01 0.751 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.809124e-01 0.743 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.818381e-01 0.740 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.818381e-01 0.740 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.841237e-01 0.735 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.841237e-01 0.735 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.841237e-01 0.735 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.849802e-01 0.733 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.849802e-01 0.733 0 0
Budding and maturation of HIV virion R-HSA-162588 1.849802e-01 0.733 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.853951e-01 0.732 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.853951e-01 0.732 0 0
Host Interactions of HIV factors R-HSA-162909 1.858394e-01 0.731 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.858798e-01 0.731 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 1.859136e-01 0.731 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.859136e-01 0.731 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.859136e-01 0.731 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.859136e-01 0.731 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.859136e-01 0.731 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.859136e-01 0.731 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.859136e-01 0.731 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.859136e-01 0.731 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.859136e-01 0.731 0 0
Hereditary fructose intolerance R-HSA-5657560 1.859136e-01 0.731 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.859136e-01 0.731 0 0
PTEN Regulation R-HSA-6807070 1.897337e-01 0.722 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.897337e-01 0.722 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.897865e-01 0.722 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.929589e-01 0.715 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.654834e-01 0.576 0 0
Defective GALK1 causes GALCT2 R-HSA-5609976 2.654834e-01 0.576 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.654834e-01 0.576 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.654834e-01 0.576 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.654834e-01 0.576 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.654834e-01 0.576 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.654834e-01 0.576 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.993753e-01 0.700 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.993753e-01 0.700 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.993753e-01 0.700 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.993753e-01 0.700 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.372802e-01 0.472 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.372802e-01 0.472 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.372802e-01 0.472 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.372802e-01 0.472 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.372802e-01 0.472 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.372802e-01 0.472 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.372802e-01 0.472 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.368681e-01 0.625 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.368681e-01 0.625 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.368681e-01 0.625 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.018581e-01 0.695 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.018581e-01 0.695 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.746833e-01 0.561 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.746833e-01 0.561 0 0
SOS-mediated signalling R-HSA-112412 2.746833e-01 0.561 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 2.746833e-01 0.561 0 0
Recycling of eIF2:GDP R-HSA-72731 2.746833e-01 0.561 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.746833e-01 0.561 0 0
Disorders of Nervous System Development R-HSA-9697154 2.283938e-01 0.641 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.283938e-01 0.641 0 0
Pervasive developmental disorders R-HSA-9005895 2.283938e-01 0.641 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.283938e-01 0.641 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.283938e-01 0.641 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.283938e-01 0.641 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.283938e-01 0.641 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.283938e-01 0.641 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.124000e-01 0.505 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.124000e-01 0.505 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.555281e-01 0.593 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.555281e-01 0.593 0 0
GAB1 signalosome R-HSA-180292 2.139569e-01 0.670 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.139569e-01 0.670 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.990927e-01 0.701 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.990927e-01 0.701 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.990927e-01 0.701 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.355452e-01 0.628 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.496765e-01 0.456 0 0
WNT mediated activation of DVL R-HSA-201688 3.496765e-01 0.456 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.496765e-01 0.456 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.496765e-01 0.456 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.576200e-01 0.589 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.576200e-01 0.589 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.576200e-01 0.589 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.576200e-01 0.589 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.108464e-01 0.507 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.108464e-01 0.507 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.862386e-01 0.413 0 0
PI3K/AKT activation R-HSA-198203 3.862386e-01 0.413 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.862386e-01 0.413 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.862386e-01 0.413 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.993223e-01 0.700 0 0
Cristae formation R-HSA-8949613 2.545241e-01 0.594 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.386922e-01 0.470 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.386922e-01 0.470 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.386922e-01 0.470 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.136413e-01 0.670 0 0
RAF activation R-HSA-5673000 2.493688e-01 0.603 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.433341e-01 0.614 0 0
FGFR2 alternative splicing R-HSA-6803529 3.257616e-01 0.487 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.836806e-01 0.547 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.961585e-01 0.707 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.131346e-01 0.504 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.433150e-01 0.614 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.959227e-01 0.708 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.795583e-01 0.554 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.795583e-01 0.554 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.940844e-01 0.712 0 0
Protein ubiquitination R-HSA-8852135 2.401538e-01 0.620 0 0
Nucleosome assembly R-HSA-774815 3.060493e-01 0.514 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.060493e-01 0.514 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.942016e-01 0.531 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.222315e-01 0.492 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.385497e-01 0.470 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.139569e-01 0.670 0 0
IRE1alpha activates chaperones R-HSA-381070 2.459132e-01 0.609 0 0
GPER1 signaling R-HSA-9634597 2.232651e-01 0.651 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.576200e-01 0.589 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.283222e-01 0.641 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.131346e-01 0.504 0 0
Degradation of DVL R-HSA-4641258 3.012125e-01 0.521 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.060493e-01 0.514 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.942016e-01 0.531 0 0
G-protein activation R-HSA-202040 2.800795e-01 0.553 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.732523e-01 0.428 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.986291e-01 0.525 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.986291e-01 0.525 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.060493e-01 0.514 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.496765e-01 0.456 0 0
Nuclear RNA decay R-HSA-9930044 2.163531e-01 0.665 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.663847e-01 0.574 0 0
Regulation of Apoptosis R-HSA-169911 2.663847e-01 0.574 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.068085e-01 0.684 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.531438e-01 0.452 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.682286e-01 0.571 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.283938e-01 0.641 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.496765e-01 0.456 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.108464e-01 0.507 0 0
Trafficking of AMPA receptors R-HSA-399719 3.330856e-01 0.477 0 0
Orc1 removal from chromatin R-HSA-68949 2.795583e-01 0.554 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.956628e-01 0.529 0 0
Long-term potentiation R-HSA-9620244 2.171105e-01 0.663 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.576200e-01 0.589 0 0
Signal attenuation R-HSA-74749 3.862386e-01 0.413 0 0
TCR signaling R-HSA-202403 2.789325e-01 0.555 0 0
G1 Phase R-HSA-69236 2.900356e-01 0.538 0 0
Cyclin D associated events in G1 R-HSA-69231 2.900356e-01 0.538 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.017942e-01 0.695 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.098857e-01 0.678 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.651177e-01 0.577 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.848878e-01 0.415 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.068085e-01 0.684 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.116699e-01 0.506 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.654834e-01 0.576 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.124000e-01 0.505 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.830711e-01 0.548 0 0
Calcineurin activates NFAT R-HSA-2025928 3.496765e-01 0.456 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.664619e-01 0.436 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.728333e-01 0.428 0 0
HATs acetylate histones R-HSA-3214847 3.456339e-01 0.461 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.487993e-01 0.457 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.139569e-01 0.670 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.816823e-01 0.418 0 0
Developmental Cell Lineages R-HSA-9734767 3.183992e-01 0.497 0 0
Circadian clock R-HSA-9909396 1.954542e-01 0.709 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.655968e-01 0.576 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.693317e-01 0.570 0 0
Co-inhibition by PD-1 R-HSA-389948 3.270838e-01 0.485 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.993753e-01 0.700 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.830711e-01 0.548 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.108464e-01 0.507 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.356089e-01 0.628 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.857337e-01 0.544 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.857337e-01 0.544 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.248387e-01 0.488 0 0
Signaling by NOTCH R-HSA-157118 2.874592e-01 0.541 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.624230e-01 0.441 0 0
Neurofascin interactions R-HSA-447043 2.368681e-01 0.625 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.163531e-01 0.665 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.718530e-01 0.430 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.368092e-01 0.473 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.969185e-01 0.527 0 0
HIV Life Cycle R-HSA-162587 1.995228e-01 0.700 0 0
Interleukin-6 family signaling R-HSA-6783589 3.718530e-01 0.430 0 0
Platelet sensitization by LDL R-HSA-432142 2.139569e-01 0.670 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.681840e-01 0.572 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.709390e-01 0.567 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.113398e-01 0.507 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.849514e-01 0.545 0 0
Integration of energy metabolism R-HSA-163685 2.351009e-01 0.629 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.569688e-01 0.590 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.171105e-01 0.663 0 0
Polo-like kinase mediated events R-HSA-156711 2.139569e-01 0.670 0 0
Hedgehog 'off' state R-HSA-5610787 3.572270e-01 0.447 0 0
S Phase R-HSA-69242 2.686652e-01 0.571 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.663847e-01 0.574 0 0
Gene expression (Transcription) R-HSA-74160 2.526196e-01 0.598 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.473180e-01 0.607 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.654834e-01 0.576 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.654834e-01 0.576 0 0
Proton/oligopeptide cotransporters R-HSA-427975 1.993753e-01 0.700 0 0
Phosphorylation of Emi1 R-HSA-176417 1.993753e-01 0.700 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.372802e-01 0.472 0 0
Interleukin-33 signaling R-HSA-9014843 3.372802e-01 0.472 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.372802e-01 0.472 0 0
Signaling by AXIN mutants R-HSA-4839735 2.018581e-01 0.695 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.139569e-01 0.670 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.171105e-01 0.663 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.862386e-01 0.413 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.862386e-01 0.413 0 0
TBC/RABGAPs R-HSA-8854214 2.742234e-01 0.562 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.832275e-01 0.548 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.547886e-01 0.450 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.323292e-01 0.478 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.720332e-01 0.429 0 0
Co-stimulation by CD28 R-HSA-389356 3.549717e-01 0.450 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.136413e-01 0.670 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.113398e-01 0.507 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.968312e-01 0.706 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.060493e-01 0.514 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.060493e-01 0.514 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.732523e-01 0.428 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.503491e-01 0.601 0 0
Signaling by FGFR2 R-HSA-5654738 2.996150e-01 0.523 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.496765e-01 0.456 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.163531e-01 0.665 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.843900e-01 0.415 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.487993e-01 0.457 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.116699e-01 0.506 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.098857e-01 0.678 0 0
G1/S Transition R-HSA-69206 2.787532e-01 0.555 0 0
Nef and signal transduction R-HSA-164944 2.368681e-01 0.625 0 0
CHL1 interactions R-HSA-447041 2.746833e-01 0.561 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.746833e-01 0.561 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.496765e-01 0.456 0 0
Protein hydroxylation R-HSA-9629569 2.576200e-01 0.589 0 0
Gap junction trafficking R-HSA-190828 2.900356e-01 0.538 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.697163e-01 0.569 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.805894e-01 0.420 0 0
Signaling by FGFR4 R-HSA-5654743 2.742234e-01 0.562 0 0
MHC class II antigen presentation R-HSA-2132295 3.390630e-01 0.470 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.412883e-01 0.467 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.386922e-01 0.470 0 0
Signaling by FGFR3 R-HSA-5654741 3.060493e-01 0.514 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.355452e-01 0.628 0 0
PERK regulates gene expression R-HSA-381042 2.663847e-01 0.574 0 0
Reproduction R-HSA-1474165 2.515882e-01 0.599 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.737922e-01 0.563 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.933498e-01 0.533 0 0
Hedgehog 'on' state R-HSA-5632684 2.986291e-01 0.525 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.993753e-01 0.700 0 0
DSCAM interactions R-HSA-376172 3.372802e-01 0.472 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 2.746833e-01 0.561 0 0
Physiological factors R-HSA-5578768 2.830711e-01 0.548 0 0
Protein methylation R-HSA-8876725 3.108464e-01 0.507 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.545241e-01 0.594 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.732523e-01 0.428 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.732523e-01 0.428 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.732523e-01 0.428 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.547886e-01 0.450 0 0
Gap junction trafficking and regulation R-HSA-157858 3.714659e-01 0.430 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.028249e-01 0.519 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.283222e-01 0.641 0 0
Gluconeogenesis R-HSA-70263 2.232651e-01 0.651 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.496765e-01 0.456 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.862386e-01 0.413 0 0
Interleukin-37 signaling R-HSA-9008059 3.131346e-01 0.504 0 0
tRNA processing in the nucleus R-HSA-6784531 2.969185e-01 0.527 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.986097e-01 0.525 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.545241e-01 0.594 0 0
Interferon Signaling R-HSA-913531 3.143696e-01 0.503 0 0
Syndecan interactions R-HSA-3000170 3.487993e-01 0.457 0 0
Diseases of Base Excision Repair R-HSA-9605308 1.993753e-01 0.700 0 0
Activation of BH3-only proteins R-HSA-114452 3.131346e-01 0.504 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.671036e-01 0.573 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.993753e-01 0.700 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.746833e-01 0.561 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.746833e-01 0.561 0 0
Regulation of KIT signaling R-HSA-1433559 2.830711e-01 0.548 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.496765e-01 0.456 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.496765e-01 0.456 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.108464e-01 0.507 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.862386e-01 0.413 0 0
Inositol phosphate metabolism R-HSA-1483249 2.993199e-01 0.524 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.386922e-01 0.470 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.257616e-01 0.487 0 0
Interleukin-1 processing R-HSA-448706 3.496765e-01 0.456 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.496765e-01 0.456 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.800795e-01 0.553 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.496765e-01 0.456 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.862386e-01 0.413 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.742234e-01 0.562 0 0
SARS-CoV Infections R-HSA-9679506 3.268443e-01 0.486 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.800795e-01 0.553 0 0
Stimuli-sensing channels R-HSA-2672351 3.546016e-01 0.450 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.028249e-01 0.519 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.880761e-01 0.411 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.899878e-01 0.409 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.909033e-01 0.408 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.909033e-01 0.408 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.909033e-01 0.408 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.909033e-01 0.408 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.933567e-01 0.405 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.933567e-01 0.405 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.933567e-01 0.405 0 0
Tight junction interactions R-HSA-420029 3.948432e-01 0.404 0 0
G protein gated Potassium channels R-HSA-1296059 3.948432e-01 0.404 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.948432e-01 0.404 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.948432e-01 0.404 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.948432e-01 0.404 0 0
HDMs demethylate histones R-HSA-3214842 3.948432e-01 0.404 0 0
Interleukin-7 signaling R-HSA-1266695 3.948432e-01 0.404 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.960538e-01 0.402 0 0
HIV Infection R-HSA-162906 4.011264e-01 0.397 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.016712e-01 0.396 0 0
FasL/ CD95L signaling R-HSA-75157 4.020629e-01 0.396 0 0
Axonal growth stimulation R-HSA-209563 4.020629e-01 0.396 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.020629e-01 0.396 0 0
MET activates PTPN11 R-HSA-8865999 4.020629e-01 0.396 0 0
Classical Kir channels R-HSA-1296053 4.020629e-01 0.396 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.020629e-01 0.396 0 0
Invadopodia formation R-HSA-8941237 4.020629e-01 0.396 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.089601e-01 0.388 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.134054e-01 0.384 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.134054e-01 0.384 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.134054e-01 0.384 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.134054e-01 0.384 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.155911e-01 0.381 0 0
Aquaporin-mediated transport R-HSA-445717 4.155911e-01 0.381 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.176959e-01 0.379 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.176959e-01 0.379 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.176959e-01 0.379 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.176959e-01 0.379 0 0
Neurexins and neuroligins R-HSA-6794361 4.210770e-01 0.376 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.212613e-01 0.375 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.218700e-01 0.375 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.218700e-01 0.375 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.218700e-01 0.375 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.269668e-01 0.370 0 0
Nucleotide Excision Repair R-HSA-5696398 4.277124e-01 0.369 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.277124e-01 0.369 0 0
Heme signaling R-HSA-9707616 4.309236e-01 0.366 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.309236e-01 0.366 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.333499e-01 0.363 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.333499e-01 0.363 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.375600e-01 0.359 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.403433e-01 0.356 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.403433e-01 0.356 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.403433e-01 0.356 0 0
Signaling by NTRKs R-HSA-166520 4.428577e-01 0.354 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.448883e-01 0.352 0 0
Regulation of insulin secretion R-HSA-422356 4.457918e-01 0.351 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.462135e-01 0.350 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.480714e-01 0.349 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.480714e-01 0.349 0 0
Rap1 signalling R-HSA-392517 4.480714e-01 0.349 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.480714e-01 0.349 0 0
The NLRP3 inflammasome R-HSA-844456 4.480714e-01 0.349 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.531444e-01 0.344 0 0
RNA Polymerase III Transcription R-HSA-74158 4.531444e-01 0.344 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.531444e-01 0.344 0 0
RUNX2 regulates bone development R-HSA-8941326 4.531444e-01 0.344 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.539702e-01 0.343 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.539702e-01 0.343 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.564034e-01 0.341 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.564034e-01 0.341 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.564034e-01 0.341 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.564034e-01 0.341 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.564034e-01 0.341 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.564034e-01 0.341 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.564034e-01 0.341 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.587884e-01 0.338 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.605164e-01 0.337 0 0
HCN channels R-HSA-1296061 4.605164e-01 0.337 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.605164e-01 0.337 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.605164e-01 0.337 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.605164e-01 0.337 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.605164e-01 0.337 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.605164e-01 0.337 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.605164e-01 0.337 0 0
GABA synthesis R-HSA-888568 4.605164e-01 0.337 0 0
Sensory perception of sour taste R-HSA-9729555 4.605164e-01 0.337 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.605164e-01 0.337 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.614393e-01 0.336 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.626912e-01 0.335 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.626912e-01 0.335 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.626912e-01 0.335 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.627233e-01 0.335 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.627233e-01 0.335 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.627233e-01 0.335 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.677774e-01 0.330 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.727464e-01 0.325 0 0
Degradation of AXIN R-HSA-4641257 4.727464e-01 0.325 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.727464e-01 0.325 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.732830e-01 0.325 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.743653e-01 0.324 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.743653e-01 0.324 0 0
Signaling by NODAL R-HSA-1181150 4.743653e-01 0.324 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.743653e-01 0.324 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.747989e-01 0.323 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.803442e-01 0.318 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.803442e-01 0.318 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.819683e-01 0.317 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.819683e-01 0.317 0 0
Interleukin-1 signaling R-HSA-9020702 4.825222e-01 0.316 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.847799e-01 0.314 0 0
Glucagon-type ligand receptors R-HSA-420092 4.847799e-01 0.314 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.847799e-01 0.314 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.864707e-01 0.313 0 0
Signaling by FGFR1 R-HSA-5654736 4.864707e-01 0.313 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.864707e-01 0.313 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.864887e-01 0.313 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.864887e-01 0.313 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.897130e-01 0.310 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.897130e-01 0.310 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.897130e-01 0.310 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.897130e-01 0.310 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.897130e-01 0.310 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.897130e-01 0.310 0 0
RNA Polymerase II Transcription R-HSA-73857 4.916078e-01 0.308 0 0
Protein localization R-HSA-9609507 4.924442e-01 0.308 0 0
UCH proteinases R-HSA-5689603 4.960683e-01 0.304 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.000010e-01 0.301 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.000670e-01 0.301 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.000670e-01 0.301 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.000670e-01 0.301 0 0
Activation of the pre-replicative complex R-HSA-68962 5.064630e-01 0.295 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.064630e-01 0.295 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.064630e-01 0.295 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.064630e-01 0.295 0 0
Stabilization of p53 R-HSA-69541 5.112195e-01 0.291 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.112195e-01 0.291 0 0
RAS processing R-HSA-9648002 5.112195e-01 0.291 0 0
IRS activation R-HSA-74713 5.132586e-01 0.290 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.132586e-01 0.290 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.132586e-01 0.290 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.132586e-01 0.290 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.132586e-01 0.290 0 0
Activation of C3 and C5 R-HSA-174577 5.132586e-01 0.290 0 0
Reelin signalling pathway R-HSA-8866376 5.132586e-01 0.290 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.132586e-01 0.290 0 0
Inositol transporters R-HSA-429593 5.132586e-01 0.290 0 0
Interleukin-36 pathway R-HSA-9014826 5.132586e-01 0.290 0 0
Dual incision in TC-NER R-HSA-6782135 5.183887e-01 0.285 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.212108e-01 0.283 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.217082e-01 0.283 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.217082e-01 0.283 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.217082e-01 0.283 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.217082e-01 0.283 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.251123e-01 0.280 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.251123e-01 0.280 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.277279e-01 0.278 0 0
Signaling by Hedgehog R-HSA-5358351 5.277327e-01 0.278 0 0
Degradation of CDH1 R-HSA-9766229 5.321198e-01 0.274 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.321198e-01 0.274 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.321198e-01 0.274 0 0
Peroxisomal protein import R-HSA-9033241 5.340759e-01 0.272 0 0
Regulation of beta-cell development R-HSA-186712 5.340759e-01 0.272 0 0
Translation R-HSA-72766 5.368839e-01 0.270 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.375174e-01 0.270 0 0
Diseases of programmed cell death R-HSA-9645723 5.393439e-01 0.268 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.484938e-01 0.261 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.484938e-01 0.261 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.484938e-01 0.261 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.484938e-01 0.261 0 0
G0 and Early G1 R-HSA-1538133 5.485357e-01 0.261 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.485357e-01 0.261 0 0
Signaling by WNT in cancer R-HSA-4791275 5.485357e-01 0.261 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.485357e-01 0.261 0 0
DNA strand elongation R-HSA-69190 5.485357e-01 0.261 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.494483e-01 0.260 0 0
LDL clearance R-HSA-8964038 5.494483e-01 0.260 0 0
ER-Phagosome pathway R-HSA-1236974 5.522137e-01 0.258 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.523276e-01 0.258 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.523276e-01 0.258 0 0
HDL assembly R-HSA-8963896 5.523276e-01 0.258 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.523276e-01 0.258 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.523276e-01 0.258 0 0
Signal regulatory protein family interactions R-HSA-391160 5.523276e-01 0.258 0 0
Malate-aspartate shuttle R-HSA-9856872 5.523276e-01 0.258 0 0
Potential therapeutics for SARS R-HSA-9679191 5.593108e-01 0.252 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.608474e-01 0.251 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.608474e-01 0.251 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.608474e-01 0.251 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.608474e-01 0.251 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.608474e-01 0.251 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.608474e-01 0.251 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.608474e-01 0.251 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.608474e-01 0.251 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.608474e-01 0.251 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.608474e-01 0.251 0 0
Threonine catabolism R-HSA-8849175 5.608474e-01 0.251 0 0
PDE3B signalling R-HSA-165160 5.608474e-01 0.251 0 0
PKB-mediated events R-HSA-109703 5.608474e-01 0.251 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.608474e-01 0.251 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.608474e-01 0.251 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.608474e-01 0.251 0 0
Ion channel transport R-HSA-983712 5.632863e-01 0.249 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.646170e-01 0.248 0 0
MAP kinase activation R-HSA-450294 5.648123e-01 0.248 0 0
Signaling by FGFR R-HSA-190236 5.653313e-01 0.248 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.654023e-01 0.248 0 0
Synthesis of DNA R-HSA-69239 5.658175e-01 0.247 0 0
Gene Silencing by RNA R-HSA-211000 5.658175e-01 0.247 0 0
Interferon alpha/beta signaling R-HSA-909733 5.663764e-01 0.247 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.666093e-01 0.247 0 0
Translation of Structural Proteins R-HSA-9683701 5.666093e-01 0.247 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.676455e-01 0.246 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.688526e-01 0.245 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.688526e-01 0.245 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.688526e-01 0.245 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.730326e-01 0.242 0 0
Interleukin-1 family signaling R-HSA-446652 5.786982e-01 0.238 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.796502e-01 0.237 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.815344e-01 0.235 0 0
Erythropoietin activates RAS R-HSA-9027284 5.815344e-01 0.235 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.815344e-01 0.235 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.815344e-01 0.235 0 0
Signaling by Activin R-HSA-1502540 5.815344e-01 0.235 0 0
Activation of GABAB receptors R-HSA-991365 5.843449e-01 0.233 0 0
GABA B receptor activation R-HSA-977444 5.843449e-01 0.233 0 0
Signaling by Interleukins R-HSA-449147 5.885859e-01 0.230 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.886501e-01 0.230 0 0
DNA Repair R-HSA-73894 5.914444e-01 0.228 0 0
Deadenylation of mRNA R-HSA-429947 5.958318e-01 0.225 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.958318e-01 0.225 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.975033e-01 0.224 0 0
Platelet degranulation R-HSA-114608 5.985767e-01 0.223 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.021856e-01 0.220 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.037859e-01 0.219 0 0
Signaling by LTK in cancer R-HSA-9842640 6.037859e-01 0.219 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.037859e-01 0.219 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.037859e-01 0.219 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.037859e-01 0.219 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.037859e-01 0.219 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.037859e-01 0.219 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.037859e-01 0.219 0 0
Leukotriene receptors R-HSA-391906 6.037859e-01 0.219 0 0
HDL clearance R-HSA-8964011 6.037859e-01 0.219 0 0
Lipid particle organization R-HSA-8964572 6.037859e-01 0.219 0 0
Signaling by FGFR in disease R-HSA-1226099 6.061226e-01 0.217 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.065868e-01 0.217 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.079041e-01 0.216 0 0
Signal amplification R-HSA-392518 6.079041e-01 0.216 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.079041e-01 0.216 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.079041e-01 0.216 0 0
Transmission across Chemical Synapses R-HSA-112315 6.090562e-01 0.215 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.093121e-01 0.215 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.093121e-01 0.215 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.093121e-01 0.215 0 0
Activation of SMO R-HSA-5635838 6.093121e-01 0.215 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.093121e-01 0.215 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.178214e-01 0.209 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.256190e-01 0.204 0 0
G alpha (z) signalling events R-HSA-418597 6.282924e-01 0.202 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.326318e-01 0.199 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.356609e-01 0.197 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.356609e-01 0.197 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.356609e-01 0.197 0 0
Galactose catabolism R-HSA-70370 6.356609e-01 0.197 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.356609e-01 0.197 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.389844e-01 0.195 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.389844e-01 0.195 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.425284e-01 0.192 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.425284e-01 0.192 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.425284e-01 0.192 0 0
Netrin mediated repulsion signals R-HSA-418886 6.425284e-01 0.192 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.425284e-01 0.192 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.425284e-01 0.192 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.425284e-01 0.192 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.425284e-01 0.192 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.425284e-01 0.192 0 0
Disinhibition of SNARE formation R-HSA-114516 6.425284e-01 0.192 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.425284e-01 0.192 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.425284e-01 0.192 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.425284e-01 0.192 0 0
VLDL clearance R-HSA-8964046 6.425284e-01 0.192 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.425284e-01 0.192 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.425284e-01 0.192 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.425284e-01 0.192 0 0
Triglyceride catabolism R-HSA-163560 6.447083e-01 0.191 0 0
Glycosphingolipid transport R-HSA-9845576 6.447083e-01 0.191 0 0
GPVI-mediated activation cascade R-HSA-114604 6.447083e-01 0.191 0 0
Gastrulation R-HSA-9758941 6.451513e-01 0.190 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.460453e-01 0.190 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.460453e-01 0.190 0 0
Neuronal System R-HSA-112316 6.480962e-01 0.188 0 0
RNA Polymerase I Transcription R-HSA-73864 6.581254e-01 0.182 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.593107e-01 0.181 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.593107e-01 0.181 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.593107e-01 0.181 0 0
Insulin processing R-HSA-264876 6.593107e-01 0.181 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.605946e-01 0.180 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.605946e-01 0.180 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.605946e-01 0.180 0 0
Choline catabolism R-HSA-6798163 6.605946e-01 0.180 0 0
Potassium Channels R-HSA-1296071 6.606116e-01 0.180 0 0
Formation of the cornified envelope R-HSA-6809371 6.610428e-01 0.180 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.774846e-01 0.169 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.774846e-01 0.169 0 0
phospho-PLA2 pathway R-HSA-111995 6.774846e-01 0.169 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.774846e-01 0.169 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 6.774846e-01 0.169 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.774846e-01 0.169 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.774846e-01 0.169 0 0
Regulation by c-FLIP R-HSA-3371378 6.774846e-01 0.169 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.774846e-01 0.169 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.774846e-01 0.169 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.774846e-01 0.169 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.774846e-01 0.169 0 0
Dimerization of procaspase-8 R-HSA-69416 6.774846e-01 0.169 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.774846e-01 0.169 0 0
Alpha-defensins R-HSA-1462054 6.774846e-01 0.169 0 0
RSK activation R-HSA-444257 6.774846e-01 0.169 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.787963e-01 0.168 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.787963e-01 0.168 0 0
HIV elongation arrest and recovery R-HSA-167287 6.787963e-01 0.168 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.787963e-01 0.168 0 0
Inflammasomes R-HSA-622312 6.787963e-01 0.168 0 0
MET promotes cell motility R-HSA-8875878 6.791582e-01 0.168 0 0
Elastic fibre formation R-HSA-1566948 6.791582e-01 0.168 0 0
Depurination R-HSA-73927 6.791582e-01 0.168 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.791582e-01 0.168 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.825470e-01 0.166 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.825522e-01 0.166 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.825522e-01 0.166 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.825522e-01 0.166 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.841381e-01 0.165 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.841381e-01 0.165 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.841381e-01 0.165 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.841381e-01 0.165 0 0
Apoptotic factor-mediated response R-HSA-111471 6.841381e-01 0.165 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.841381e-01 0.165 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.841381e-01 0.165 0 0
Downstream TCR signaling R-HSA-202424 6.879130e-01 0.162 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.882982e-01 0.162 0 0
Interleukin-17 signaling R-HSA-448424 6.898242e-01 0.161 0 0
Mitochondrial biogenesis R-HSA-1592230 6.938553e-01 0.159 0 0
Amyloid fiber formation R-HSA-977225 6.943421e-01 0.158 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.954827e-01 0.158 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.964765e-01 0.157 0 0
Signaling by Erythropoietin R-HSA-9006335 6.974425e-01 0.156 0 0
DNA methylation R-HSA-5334118 6.974425e-01 0.156 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.974425e-01 0.156 0 0
PPARA activates gene expression R-HSA-1989781 6.978649e-01 0.156 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.983725e-01 0.156 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.989343e-01 0.156 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.989679e-01 0.156 0 0
ABC-family proteins mediated transport R-HSA-382556 7.036184e-01 0.153 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.063247e-01 0.151 0 0
Specification of the neural plate border R-HSA-9834899 7.063247e-01 0.151 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.063247e-01 0.151 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.063247e-01 0.151 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.063247e-01 0.151 0 0
ARMS-mediated activation R-HSA-170984 7.090244e-01 0.149 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.090244e-01 0.149 0 0
CASP8 activity is inhibited R-HSA-5218900 7.090244e-01 0.149 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.090244e-01 0.149 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.090244e-01 0.149 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.090244e-01 0.149 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.090244e-01 0.149 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.090244e-01 0.149 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.090244e-01 0.149 0 0
HIV Transcription Elongation R-HSA-167169 7.112040e-01 0.148 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.112040e-01 0.148 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.112040e-01 0.148 0 0
Generation of second messenger molecules R-HSA-202433 7.112040e-01 0.148 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.112040e-01 0.148 0 0
Diseases of Immune System R-HSA-5260271 7.112040e-01 0.148 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.112040e-01 0.148 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.112040e-01 0.148 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.119207e-01 0.148 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.152555e-01 0.146 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.152555e-01 0.146 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.170813e-01 0.144 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.224159e-01 0.141 0 0
Generic Transcription Pathway R-HSA-212436 7.237905e-01 0.140 0 0
Meiotic recombination R-HSA-912446 7.243656e-01 0.140 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.243656e-01 0.140 0 0
Mitochondrial protein import R-HSA-1268020 7.245178e-01 0.140 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.245178e-01 0.140 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.263231e-01 0.139 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.271947e-01 0.138 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.271947e-01 0.138 0 0
Creatine metabolism R-HSA-71288 7.271947e-01 0.138 0 0
Viral Infection Pathways R-HSA-9824446 7.317029e-01 0.136 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.322453e-01 0.135 0 0
Downstream signal transduction R-HSA-186763 7.322453e-01 0.135 0 0
Aspartate and asparagine metabolism R-HSA-8963693 7.322453e-01 0.135 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.347485e-01 0.134 0 0
2-LTR circle formation R-HSA-164843 7.374815e-01 0.132 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.374815e-01 0.132 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.374815e-01 0.132 0 0
Regulation of CDH11 function R-HSA-9762292 7.374815e-01 0.132 0 0
Binding and entry of HIV virion R-HSA-173107 7.374815e-01 0.132 0 0
DNA replication initiation R-HSA-68952 7.374815e-01 0.132 0 0
Interleukin-27 signaling R-HSA-9020956 7.374815e-01 0.132 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.374815e-01 0.132 0 0
Signaling by Leptin R-HSA-2586552 7.374815e-01 0.132 0 0
Formation of apoptosome R-HSA-111458 7.374815e-01 0.132 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.383943e-01 0.132 0 0
Leishmania phagocytosis R-HSA-9664417 7.383943e-01 0.132 0 0
Parasite infection R-HSA-9664407 7.383943e-01 0.132 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.408438e-01 0.130 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.467932e-01 0.127 0 0
Iron uptake and transport R-HSA-917937 7.482824e-01 0.126 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.484255e-01 0.126 0 0
IGF1R signaling cascade R-HSA-2428924 7.485410e-01 0.126 0 0
Ion transport by P-type ATPases R-HSA-936837 7.485410e-01 0.126 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.547718e-01 0.122 0 0
Depyrimidination R-HSA-73928 7.547718e-01 0.122 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.590949e-01 0.120 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.599685e-01 0.119 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.626615e-01 0.118 0 0
PECAM1 interactions R-HSA-210990 7.631570e-01 0.117 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.631570e-01 0.117 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.631570e-01 0.117 0 0
vRNA Synthesis R-HSA-192814 7.631570e-01 0.117 0 0
vRNP Assembly R-HSA-192905 7.631570e-01 0.117 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.631570e-01 0.117 0 0
Bicarbonate transporters R-HSA-425381 7.631570e-01 0.117 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.631570e-01 0.117 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.631570e-01 0.117 0 0
Suppression of apoptosis R-HSA-9635465 7.631570e-01 0.117 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.631570e-01 0.117 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.631570e-01 0.117 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.638128e-01 0.117 0 0
Attachment and Entry R-HSA-9694614 7.651694e-01 0.116 0 0
Defective pyroptosis R-HSA-9710421 7.681149e-01 0.115 0 0
Signaling by SCF-KIT R-HSA-1433557 7.681149e-01 0.115 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.692281e-01 0.114 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.744946e-01 0.111 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.784261e-01 0.109 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.784261e-01 0.109 0 0
ABC transporter disorders R-HSA-5619084 7.793738e-01 0.108 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.823748e-01 0.107 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 7.823748e-01 0.107 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.823748e-01 0.107 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.823748e-01 0.107 0 0
Ion homeostasis R-HSA-5578775 7.858703e-01 0.105 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.858703e-01 0.105 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.863228e-01 0.104 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 7.863228e-01 0.104 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.863228e-01 0.104 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.863228e-01 0.104 0 0
ERKs are inactivated R-HSA-202670 7.863228e-01 0.104 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.863228e-01 0.104 0 0
Integration of provirus R-HSA-162592 7.863228e-01 0.104 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.870944e-01 0.104 0 0
Leishmania infection R-HSA-9658195 7.876869e-01 0.104 0 0
Parasitic Infection Pathways R-HSA-9824443 7.876869e-01 0.104 0 0
FOXO-mediated transcription R-HSA-9614085 7.954820e-01 0.099 0 0
Base Excision Repair R-HSA-73884 7.964752e-01 0.099 0 0
IRS-mediated signalling R-HSA-112399 7.967952e-01 0.099 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.984625e-01 0.098 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.984625e-01 0.098 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.051349e-01 0.094 0 0
Interferon gamma signaling R-HSA-877300 8.063253e-01 0.093 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.072239e-01 0.093 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.072239e-01 0.093 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.072239e-01 0.093 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.072239e-01 0.093 0 0
MET activates RAS signaling R-HSA-8851805 8.072239e-01 0.093 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.072239e-01 0.093 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.072239e-01 0.093 0 0
Interleukin-35 Signalling R-HSA-8984722 8.072239e-01 0.093 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.072239e-01 0.093 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.072239e-01 0.093 0 0
Estrogen biosynthesis R-HSA-193144 8.072239e-01 0.093 0 0
Signaling by LTK R-HSA-9842663 8.072239e-01 0.093 0 0
OAS antiviral response R-HSA-8983711 8.072239e-01 0.093 0 0
Interleukin-15 signaling R-HSA-8983432 8.072239e-01 0.093 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.105126e-01 0.091 0 0
Toll-like Receptor Cascades R-HSA-168898 8.107522e-01 0.091 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.113792e-01 0.091 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.134866e-01 0.090 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.134866e-01 0.090 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.134866e-01 0.090 0 0
Triglyceride metabolism R-HSA-8979227 8.173243e-01 0.088 0 0
Chromosome Maintenance R-HSA-73886 8.175615e-01 0.087 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.178406e-01 0.087 0 0
G1/S-Specific Transcription R-HSA-69205 8.178406e-01 0.087 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.205490e-01 0.086 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.205490e-01 0.086 0 0
Cardiac conduction R-HSA-5576891 8.241066e-01 0.084 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.260816e-01 0.083 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.260816e-01 0.083 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.260816e-01 0.083 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.260816e-01 0.083 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.260816e-01 0.083 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.260816e-01 0.083 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.260816e-01 0.083 0 0
Processing of SMDT1 R-HSA-8949664 8.260816e-01 0.083 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.260816e-01 0.083 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.260816e-01 0.083 0 0
Maturation of nucleoprotein R-HSA-9683610 8.260816e-01 0.083 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.260816e-01 0.083 0 0
GABA receptor activation R-HSA-977443 8.269464e-01 0.083 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.275012e-01 0.082 0 0
Laminin interactions R-HSA-3000157 8.275012e-01 0.082 0 0
Cleavage of the damaged purine R-HSA-110331 8.295831e-01 0.081 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.304988e-01 0.081 0 0
DNA Replication R-HSA-69306 8.364365e-01 0.078 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.378256e-01 0.077 0 0
HCMV Early Events R-HSA-9609690 8.383941e-01 0.077 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.405599e-01 0.075 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.405599e-01 0.075 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.405599e-01 0.075 0 0
TRP channels R-HSA-3295583 8.405599e-01 0.075 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.430957e-01 0.074 0 0
Hydrolysis of LPC R-HSA-1483115 8.430957e-01 0.074 0 0
cGMP effects R-HSA-418457 8.430957e-01 0.074 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.430957e-01 0.074 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.430957e-01 0.074 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.430957e-01 0.074 0 0
Zinc transporters R-HSA-435354 8.430957e-01 0.074 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.430957e-01 0.074 0 0
Adaptive Immune System R-HSA-1280218 8.440149e-01 0.074 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.449546e-01 0.073 0 0
PI3K Cascade R-HSA-109704 8.460948e-01 0.073 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.460948e-01 0.073 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.511267e-01 0.070 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.527155e-01 0.069 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.527155e-01 0.069 0 0
Packaging Of Telomere Ends R-HSA-171306 8.527155e-01 0.069 0 0
Signaling by BMP R-HSA-201451 8.527155e-01 0.069 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.527155e-01 0.069 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.527155e-01 0.069 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.527155e-01 0.069 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.527155e-01 0.069 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.533619e-01 0.069 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.533619e-01 0.069 0 0
Platelet homeostasis R-HSA-418346 8.545639e-01 0.068 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.584462e-01 0.066 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.584462e-01 0.066 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.584462e-01 0.066 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.584462e-01 0.066 0 0
Transport and metabolism of PAPS R-HSA-174362 8.584462e-01 0.066 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.584462e-01 0.066 0 0
Other semaphorin interactions R-HSA-416700 8.584462e-01 0.066 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.584462e-01 0.066 0 0
Formation of the anterior neural plate R-HSA-9823739 8.584462e-01 0.066 0 0
Neddylation R-HSA-8951664 8.591199e-01 0.066 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.609800e-01 0.065 0 0
Insulin receptor signalling cascade R-HSA-74751 8.613862e-01 0.065 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.638404e-01 0.064 0 0
Translation of Structural Proteins R-HSA-9694635 8.683401e-01 0.061 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.702558e-01 0.060 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.718747e-01 0.060 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.722957e-01 0.059 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.722957e-01 0.059 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.722957e-01 0.059 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.722957e-01 0.059 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.722957e-01 0.059 0 0
Killing mechanisms R-HSA-9664420 8.722957e-01 0.059 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.722957e-01 0.059 0 0
Prolonged ERK activation events R-HSA-169893 8.722957e-01 0.059 0 0
Fructose catabolism R-HSA-70350 8.722957e-01 0.059 0 0
Attachment and Entry R-HSA-9678110 8.722957e-01 0.059 0 0
mRNA Capping R-HSA-72086 8.745230e-01 0.058 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.745230e-01 0.058 0 0
Platelet calcium homeostasis R-HSA-418360 8.745230e-01 0.058 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.751753e-01 0.058 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.754551e-01 0.058 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.754551e-01 0.058 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.789802e-01 0.056 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.817107e-01 0.055 0 0
DAP12 signaling R-HSA-2424491 8.842735e-01 0.053 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.842735e-01 0.053 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.847910e-01 0.053 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.847910e-01 0.053 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.847910e-01 0.053 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.847910e-01 0.053 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.847910e-01 0.053 0 0
Heme assimilation R-HSA-9927020 8.847910e-01 0.053 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.847910e-01 0.053 0 0
Phase 2 - plateau phase R-HSA-5576893 8.847910e-01 0.053 0 0
Synthesis of PG R-HSA-1483148 8.847910e-01 0.053 0 0
Coenzyme A biosynthesis R-HSA-196783 8.847910e-01 0.053 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.847910e-01 0.053 0 0
Transcription of the HIV genome R-HSA-167172 8.898830e-01 0.051 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.909385e-01 0.050 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.909385e-01 0.050 0 0
PI Metabolism R-HSA-1483255 8.933953e-01 0.049 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.943243e-01 0.049 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.957334e-01 0.048 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.957334e-01 0.048 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.960643e-01 0.048 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.960643e-01 0.048 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.960643e-01 0.048 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.960643e-01 0.048 0 0
GDP-fucose biosynthesis R-HSA-6787639 8.960643e-01 0.048 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.960643e-01 0.048 0 0
Catecholamine biosynthesis R-HSA-209905 8.960643e-01 0.048 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.960643e-01 0.048 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.960643e-01 0.048 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.960643e-01 0.048 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.960643e-01 0.048 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.960643e-01 0.048 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.000466e-01 0.046 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.050326e-01 0.043 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.062351e-01 0.043 0 0
Tie2 Signaling R-HSA-210993 9.062351e-01 0.043 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.062351e-01 0.043 0 0
Mismatch Repair R-HSA-5358508 9.062351e-01 0.043 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.062351e-01 0.043 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.069073e-01 0.042 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.086741e-01 0.042 0 0
HCMV Late Events R-HSA-9610379 9.094099e-01 0.041 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.094663e-01 0.041 0 0
Cardiogenesis R-HSA-9733709 9.094663e-01 0.041 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.094663e-01 0.041 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.127744e-01 0.040 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.152160e-01 0.038 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.152160e-01 0.038 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.152160e-01 0.038 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.152953e-01 0.038 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.154111e-01 0.038 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.154111e-01 0.038 0 0
Pyrimidine biosynthesis R-HSA-500753 9.154111e-01 0.038 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.154111e-01 0.038 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.154111e-01 0.038 0 0
Other interleukin signaling R-HSA-449836 9.154111e-01 0.038 0 0
Maturation of nucleoprotein R-HSA-9694631 9.154111e-01 0.038 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.154111e-01 0.038 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.166534e-01 0.038 0 0
Synthesis of PC R-HSA-1483191 9.211550e-01 0.036 0 0
G alpha (s) signalling events R-HSA-418555 9.215575e-01 0.035 0 0
HCMV Infection R-HSA-9609646 9.229724e-01 0.035 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.233015e-01 0.035 0 0
Gap junction assembly R-HSA-190861 9.233015e-01 0.035 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.233015e-01 0.035 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.236897e-01 0.034 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.236897e-01 0.034 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.236897e-01 0.034 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.236897e-01 0.034 0 0
Pregnenolone biosynthesis R-HSA-196108 9.236897e-01 0.034 0 0
Signal transduction by L1 R-HSA-445144 9.236897e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.236897e-01 0.034 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.294472e-01 0.032 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.294472e-01 0.032 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.294472e-01 0.032 0 0
Signalling to ERKs R-HSA-187687 9.294472e-01 0.032 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.311585e-01 0.031 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.311585e-01 0.031 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.311585e-01 0.031 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.311585e-01 0.031 0 0
Signalling to RAS R-HSA-167044 9.311585e-01 0.031 0 0
ERK/MAPK targets R-HSA-198753 9.311585e-01 0.031 0 0
Abacavir metabolism R-HSA-2161541 9.311585e-01 0.031 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.311585e-01 0.031 0 0
Lagging Strand Synthesis R-HSA-69186 9.311585e-01 0.031 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.351252e-01 0.029 0 0
Hemostasis R-HSA-109582 9.359060e-01 0.029 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.378967e-01 0.028 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.378967e-01 0.028 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.378967e-01 0.028 0 0
Ribavirin ADME R-HSA-9755088 9.378967e-01 0.028 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.378967e-01 0.028 0 0
Serine metabolism R-HSA-977347 9.378967e-01 0.028 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.378967e-01 0.028 0 0
Neurotransmitter release cycle R-HSA-112310 9.400081e-01 0.027 0 0
Voltage gated Potassium channels R-HSA-1296072 9.403680e-01 0.027 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.403680e-01 0.027 0 0
SLC transporter disorders R-HSA-5619102 9.411193e-01 0.026 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.431383e-01 0.025 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.433662e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.439757e-01 0.025 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.439757e-01 0.025 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.439757e-01 0.025 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.439757e-01 0.025 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.439757e-01 0.025 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.439757e-01 0.025 0 0
Fructose metabolism R-HSA-5652084 9.439757e-01 0.025 0 0
Signaling by KIT in disease R-HSA-9669938 9.439757e-01 0.025 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.439757e-01 0.025 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.439757e-01 0.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.452065e-01 0.024 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.452065e-01 0.024 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.455206e-01 0.024 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.494600e-01 0.023 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.494600e-01 0.023 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.494600e-01 0.023 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.494600e-01 0.023 0 0
Biosynthesis of maresins R-HSA-9018682 9.494600e-01 0.023 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.494600e-01 0.023 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.494600e-01 0.023 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.494600e-01 0.023 0 0
Carnitine shuttle R-HSA-200425 9.494600e-01 0.023 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.494600e-01 0.023 0 0
Growth hormone receptor signaling R-HSA-982772 9.494600e-01 0.023 0 0
Signaling by ALK R-HSA-201556 9.496695e-01 0.022 0 0
Signaling by Insulin receptor R-HSA-74752 9.498223e-01 0.022 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.498223e-01 0.022 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.504119e-01 0.022 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.509728e-01 0.022 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.527574e-01 0.021 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.537842e-01 0.021 0 0
Interleukin-2 family signaling R-HSA-451927 9.537842e-01 0.021 0 0
CYP2E1 reactions R-HSA-211999 9.544077e-01 0.020 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.544077e-01 0.020 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.544077e-01 0.020 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.544077e-01 0.020 0 0
Complex III assembly R-HSA-9865881 9.544077e-01 0.020 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.544077e-01 0.020 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.544077e-01 0.020 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.588713e-01 0.018 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.588713e-01 0.018 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.588713e-01 0.018 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.588713e-01 0.018 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.610685e-01 0.017 0 0
HIV Transcription Initiation R-HSA-167161 9.610685e-01 0.017 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.610685e-01 0.017 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.610685e-01 0.017 0 0
MET activates PTK2 signaling R-HSA-8874081 9.628982e-01 0.016 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.628982e-01 0.016 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.628982e-01 0.016 0 0
Abacavir ADME R-HSA-2161522 9.628982e-01 0.016 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.639986e-01 0.016 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.642841e-01 0.016 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.664441e-01 0.015 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.665310e-01 0.015 0 0
Triglyceride biosynthesis R-HSA-75109 9.665310e-01 0.015 0 0
Synthesis of PE R-HSA-1483213 9.665310e-01 0.015 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.672436e-01 0.014 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.673327e-01 0.014 0 0
Extension of Telomeres R-HSA-180786 9.680565e-01 0.014 0 0
Telomere Extension By Telomerase R-HSA-171319 9.698083e-01 0.013 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.698083e-01 0.013 0 0
Insulin receptor recycling R-HSA-77387 9.698083e-01 0.013 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.698083e-01 0.013 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.698083e-01 0.013 0 0
Pyrimidine salvage R-HSA-73614 9.698083e-01 0.013 0 0
Pyroptosis R-HSA-5620971 9.698083e-01 0.013 0 0
DAP12 interactions R-HSA-2172127 9.699661e-01 0.013 0 0
Surfactant metabolism R-HSA-5683826 9.699661e-01 0.013 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.724698e-01 0.012 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.724698e-01 0.012 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.726603e-01 0.012 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.727648e-01 0.012 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.727648e-01 0.012 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.743122e-01 0.011 0 0
Immune System R-HSA-168256 9.743905e-01 0.011 0 0
Signaling by PDGF R-HSA-186797 9.747191e-01 0.011 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.747713e-01 0.011 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.754214e-01 0.011 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.754320e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.754320e-01 0.011 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.763712e-01 0.010 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.763712e-01 0.010 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.765077e-01 0.010 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.768863e-01 0.010 0 0
Cargo concentration in the ER R-HSA-5694530 9.778382e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.782490e-01 0.010 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.786164e-01 0.009 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.800088e-01 0.009 0 0
HS-GAG degradation R-HSA-2024096 9.800088e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.819669e-01 0.008 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.837333e-01 0.007 0 0
Heme degradation R-HSA-189483 9.837333e-01 0.007 0 0
Complex IV assembly R-HSA-9864848 9.837544e-01 0.007 0 0
The phototransduction cascade R-HSA-2514856 9.837544e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.850272e-01 0.007 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.851335e-01 0.007 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.853268e-01 0.006 0 0
eNOS activation R-HSA-203615 9.853268e-01 0.006 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.853268e-01 0.006 0 0
RA biosynthesis pathway R-HSA-5365859 9.853268e-01 0.006 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.853268e-01 0.006 0 0
tRNA processing R-HSA-72306 9.858300e-01 0.006 0 0
Telomere Maintenance R-HSA-157579 9.861707e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.863984e-01 0.006 0 0
Nucleotide biosynthesis R-HSA-8956320 9.863984e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.866272e-01 0.006 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.867643e-01 0.006 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.867643e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.872397e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.876342e-01 0.005 0 0
HS-GAG biosynthesis R-HSA-2022928 9.880610e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.886215e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.892308e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.892308e-01 0.005 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.892308e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.892308e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.892308e-01 0.005 0 0
G alpha (q) signalling events R-HSA-416476 9.900245e-01 0.004 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.912379e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.912379e-01 0.004 0 0
Keratinization R-HSA-6805567 9.922749e-01 0.003 0 0
RAB geranylgeranylation R-HSA-8873719 9.927411e-01 0.003 0 0
tRNA Aminoacylation R-HSA-379724 9.927411e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.927411e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.928711e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.928711e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.930420e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.935698e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.939345e-01 0.003 0 0
Defensins R-HSA-1461973 9.947685e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.947685e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.949494e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.951243e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.951954e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.952813e-01 0.002 0 0
Methylation R-HSA-156581 9.952813e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.952813e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.957439e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.961587e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.961587e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.965375e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.968770e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.970822e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.971832e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.971832e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.973134e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.973385e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.973385e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.973385e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.974594e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.974594e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.976811e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.977086e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.977865e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.977945e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.985425e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.986067e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986325e-01 0.001 0 0
Scavenging of heme from plasma R-HSA-2168880 9.987166e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.987304e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.987666e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.987666e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.989636e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.989968e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989968e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.990921e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.990952e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.991762e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.991840e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991840e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993363e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.994014e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.995017e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.995131e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995609e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.995609e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996040e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.996040e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.996402e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996724e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996897e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997096e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997096e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997096e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997170e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997381e-01 0.000 0 0
Disease R-HSA-1643685 9.997597e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997870e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.997964e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998313e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998575e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998591e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998642e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998709e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998730e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998967e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998967e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999243e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999321e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999357e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999366e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999445e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999451e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999533e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999661e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999697e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999781e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999803e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999915e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999924e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999935e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999947e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999957e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999959e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999959e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999969e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999989e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999990e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999991e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999993e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999994e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999994e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways