PKACB

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00141 T369 ELM SGK1 SGK IKSHVFFSLINWDDLINKKItPPFNPNVsGPNDLRHFDPEF
O00168 S83 ELM FXYD1 PLM KFNQQQRTGEPDEEEGtFRssIRRLstRRR___________
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00299 S211 Sugiyama CLIC1 G6 NCC27 CKKYRGFTIPEAFRGVHRYLsNAyAREEFAstCPDDEEIEL
O00429 S637 SIGNOR|ELM DNM1L DLP1 DRP1 PQKGHAVNLLDVPVPVARKLsAREQRDCEVIERLIKSYFLI
O00458 T9 Sugiyama IFRD1 ____________MPKNKKRNtPHRGssAGGGGsGAAAATAA
O00482 S510 SIGNOR NR5A2 B1F CPF FTF PQQTEKFGQLLLRLPEIRAIsMQAEEYLYYKHLNGDVPYNN
O00571 S83 Sugiyama DDX3X DBX DDX3 sKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRsD
O00750 S225 Sugiyama PIK3C2B HRILEEEEVLGGGGQGRLLGsVDyDGINDAITRLNLKSTYD
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14737 S42 Sugiyama PDCD5 TFAR19 GDPGDAAQQEAKHREAEMRNsILAQVLDQsARARLsNLALV
O14965 T288 ELM AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 GELKIADFGWsVHAPssRRttLCGTLDYLPPEMIEGRMHDE
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O14974 T696 Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067 S1053 Sugiyama PFAS KIAA0361 RGLRERMGPSYCLPPTFPKAsVPREPGGPsPRVAILREEGS
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15143 S310 Sugiyama ARPC1B ARC41 QSSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVs
O15217 S189 SIGNOR GSTA4 EKIPNILSAFPFLQEYTVKLsNIPtIKRFLEPGSKKKPPPD
O15226 S618 Sugiyama NKRF ITBA4 NRF VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15357 S43 Sugiyama INPPL1 SHIP2 HRDLSRAAAEELLARAGRDGsFLVRDSESVAGAFALCVLYQ
O15372 S290 Sugiyama EIF3H EIF3S3 QQQQKHQYQQRRQQENMQRQsRGEPPLPEEDLsKLFKPPQP
O43493 S428 Sugiyama TGOLN2 TGN46 TGN51 KIIAFVLEGKRSKVTRRPKAsDyQRLDQKS___________
O43566 S260 ELM RGS14 LRKSFRRELGGTANAALRREsQGSLNSSASLDLGFLAFVSS
O43623 S247 SIGNOR SNAI2 SLUG SLUGH NLRAHLQTHsDVKKYQCKNCsKTFsRMsLLHKHEESGCCVA
O43707 S423 Sugiyama ACTN4 NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEt
O60291 S515 Sugiyama MGRN1 KIAA0544 RNF156 sFItEEVDESssPQQGTRAAsIENVLQDssPEHCGRGPPAD
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343 S757 Sugiyama TBC1D4 AS160 KIAA0603 ASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQRIF
O60343 S759 Sugiyama TBC1D4 AS160 KIAA0603 ESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQRIFLR
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60610 T768 SIGNOR DIAPH1 DIAP1 PPPPPFGFGVPAAPVLPFGLtPKKLYKPEVQLRRPNWSKLV
O60658 S359 SIGNOR PDE8A VQSDTHTDNQTGKHKDRRKGsLDVKAVASRATEVSSQRRHS
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75151 S1056 SIGNOR PHF2 CENP-35 KIAA0662 QAGRTSQPMAPGVFLtQRRPsAssPNNNTAAKGKRTKKGMA
O75151 S757 SIGNOR PHF2 CENP-35 KIAA0662 GSLHIDTDTKPGRNARVKKEsGSSAAGILDLLQASEEVGAL
O75151 S899 SIGNOR PHF2 CENP-35 KIAA0662 sLEsDEDNPIFKSRSKKRKGsDDAPYsPtARVGPSVPRQDR
O75151 S954 SIGNOR PHF2 CENP-35 KIAA0662 LAAAAAKLsQQEEQKSKKKKsAKRKLTPNTTSPSTSTSISA
O75369 S1442 Sugiyama FLNB FLN1L FLN3 TABP TAP SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O75396 S137 Sugiyama SEC22B SEC22L1 TFIQKTKKLYIDSRARRNLGsINtELQDVQRIMVANIEEVL
O75581 T1548 SIGNOR LRP6 PtTPCSTDVCDsDyAPsRRMtSVATAKGYTSDLNyDSEPVP
O75688 S195 SIGNOR PPM1B PP2CB REKERIQNAGGsVMIQRVNGsLAVSRALGDYDYKCVDGKGP
O75717 S374 Sugiyama WDHD1 AND1 INDDEDDEDLMMAsGRPRQRsHILEDDENsVDIsMLKtGss
O76054 S289 SIGNOR SEC14L2 C22orf6 KIAA1186 KIAA1658 YVRDQVKQQYEHSVQISRGSsHQVEYEILFPGCVLRWQFMS
O76074 S102 ELM PDE5A PDE5 PLQQsPRADNSAPGTPTRKIsAsEFDRPLRPIVVKDSEGTV
O94806 S731 SIGNOR PRKD3 EPK2 PRKCN EPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRSK
O94808 S202 ELM GFPT2 FALVFKSVHYPGEAVATRRGsPLLIGVRSKYKLSTEQIPIL
O94888 S280 Sugiyama UBXN7 KIAA0794 UBXD7 EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE
O95140 S442 SIGNOR MFN2 CPRP1 KIAA0214 ITEEVERQVSTAMAEEIRRLsVLVDDYQMDFHPSPVVLKVY
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95302 S275 Sugiyama FKBP9 FKBP60 FKBP63 NPKDSISIENKVVPENCERIsQsGDFLRYHYNGTLLDGTLF
O95453 S557 Sugiyama PARN DAN KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95477 S1042 ELM ABCA1 ABC1 CERP PSSKLKSKTSQLSGGMQRKLsVALAFVGGSKVVILDEPTAG
O95477 S2054 ELM ABCA1 ABC1 CERP LVKYGEKYAGNYSGGNKRKLsTAMALIGGPPVVFLDEPTTG
O95613 S1814 Sugiyama PCNT KIAA0402 PCNT2 AALEAKEALSRLLADQERRHsQALEALQQRLQGAEEAAELQ
O95644 S245 ELM NFATC1 NFAT2 NFATC LGACtLLGsPRHsPstsPRAsVTEESWLGARssRPAsPCNK
O95644 S269 ELM NFATC1 NFAT2 NFATC ESWLGARssRPAsPCNKRKYsLNGRQPPysPHHsPtPSPHG
O95644 S294 ELM NFATC1 NFAT2 NFATC QPPysPHHsPtPSPHGsPRVsVTDDSWLGNTTQYTSSAIVA
O95817 S195 Sugiyama BAG3 BIS AAsDCsssSsSAsLPssGRssLGsHQLPRGyISIPVIHEQN
O96004 S109 ELM HAND1 BHLHA27 EHAND GGRLGRRKGsGPKKERRRtEsINSAFAELRECIPNVPADTK
O96004 S98 ELM HAND1 BHLHA27 EHAND PGQSPGRLEALGGRLGRRKGsGPKKERRRtEsINSAFAELR
O96004 T107 ELM HAND1 BHLHA27 EHAND ALGGRLGRRKGsGPKKERRRtEsINSAFAELRECIPNVPAD
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00439 S16 ELM PAH _____MSTAVLENPGLGRKLsDFGQETSYIEDNCNQNGAIS
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00540 S73 SIGNOR MOS CSIDWEQVCLLQRLGAGGFGsVYKATYRGVPVAIKQVNKCT
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P01023 S273 Sugiyama A2M CPAMD5 FWP007 LYTYGKPVPGHVTVSICRKYsDAsDCHGEDSQAFCEKFSGQ
P02671 S460 ELM FGA KELRTGKEKVTSGSTTTTRRsCSKTVTKTVIGPDGHKEVTK
P03372 S236 ELM ESR1 ESR NR3A1 HNDyMCPATNQCTIDKNRRKsCQACRLRKCYEVGMMKGGIR
P04004 S397 ELM VTN KGYRsQRGHsRGRNQNsRRPsRAtWLsLFssEEsNLGANNY
P04049 S259 ELM RAF1 RAF tFNtssPSSEGSLSQRQRststPNVHMVsttLPVDSRMIED
P04049 S43 ELM RAF1 RAF DGssCIsPtIVQQFGYQRRAsDDGKLtDPSKTSNTIRVFLP
P04049 S621 ELM RAF1 RAF QILssIELLQHsLPKINRsAsEPsLHRAAHtEDINACtLtt
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 T216 ELM ANXA1 ANX1 LPC1 EDLADsDARALyEAGERRKGtDVNVFNtILttRSyPQLRRV
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04439 S336 ELM HLA-A HLAA VLLGAVITGAVVAAVMWRRKssDRKGGsyTQAASSDSAQGS
P04439 S337 ELM HLA-A HLAA LLGAVITGAVVAAVMWRRKssDRKGGsyTQAASSDSAQGSD
P04439 S343 ELM HLA-A HLAA TGAVVAAVMWRRKssDRKGGsyTQAASSDSAQGSDVsLTAC
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04908 S20 Sugiyama H2AC4 H2AFM HIST1H2AB; H2AC8 H2AFA HIST1H2AE _MSGRGKQGGKARAKAKTRSsRAGLQFPVGRVHRLLRKGNY
P05114 S21 ELM HMGN1 HMG14 MPKRKVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAA
P05114 S25 ELM HMGN1 HMG14 KVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAAKDKS
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06733 S349 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV
P06744 T109 Sugiyama GPI KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07101 S71 ELM TH TYH APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07384 S474 Sugiyama CAPN1 CANPL1 PIG30 GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07550 S262 ELM ADRB2 ADRB2R B2AR VQNLsQVEQDGRTGHGLRRssKFCLKEHKALKTLGIIMGTF
P07550 S345 ELM ADRB2 ADRB2R B2AR IyCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsG
P07550 S346 ELM ADRB2 ADRB2R B2AR yCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsGY
P07602 S29 Sugiyama PSAP GLBA SAP1 SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737 S72 Sugiyama PFN1 VGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKs
P07737 S77 Sugiyama PFN1 ssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAP
P07814 S330 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 KHRKNPIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGC
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08034 S233 ELM GJB1 CX32 IIRACARRAQRRSNPPsRKGsGFGHRLSPEyKQNEINKLLS
P08138 S303 SIGNOR|ELM|iPTMNet|EPSD|PSP NGFR TNFRSF16 QGANsRPVNQtPPPEGEKLHsDsGIsVDsQsLHDQQPHTQT
P08151 T374 SIGNOR GLI1 GLI RTHSNEKPYVCKLPGCTKRYtDPSSLRKHVKTVHGPDAHVt
P08183 S667 ELM ABCB1 MDR1 PGY1 EIDALEMssNDsRssLIRKRsTRRsVRGSQAQDRKLsTKEA
P08183 S683 ELM ABCB1 MDR1 PGY1 IRKRsTRRsVRGSQAQDRKLsTKEALDESIPPVSFWRIMKL
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 S615 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tyGWTANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIV
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P09525 S125 Sugiyama ANXA4 ANX4 DEGCLIEILASRTPEEIRRIsQtYQQQYGRSLEDDIRSDTS
P09525 T127 Sugiyama ANXA4 ANX4 GCLIEILASRTPEEIRRIsQtYQQQYGRSLEDDIRSDTSFM
P09651 S199 ELM HNRNPA1 HNRPA1 KALSKQEMAsAsssQRGRsGsGNFGGGRGGGFGGNDNFGRG
P09917 S272 ELM ALOX5 LOG5 LPEKLPVtTEMVECSLERQLsLEQEVQQGNIFIVDFELLDG
P09917 S524 ELM ALOX5 LOG5 PELQDFVNDVYVYGMRGRKSsGFPKSVKSREQLSEYLTVVI
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0C0S8 S20 Sugiyama H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM _MsGRGKQGGKARAKAKTRssRAGLQFPVGRVHRLLRKGNY
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DN86 S116 ELM CGB3 CGB; CGB5; CGB8 VNPVVSYAVALSCQCALCRRstTDCGGPKDHPLTCDDPRFQ
P0DN86 S86 ELM CGB3 CGB; CGB5; CGB8 QGVLPALPQVVCNYRDVRFEsIRLPGCPRGVNPVVSYAVAL
P0DN86 T117 ELM CGB3 CGB; CGB5; CGB8 NPVVSYAVALSCQCALCRRstTDCGGPKDHPLTCDDPRFQD
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10636 S531 ELM MAPT MAPTL MTBT1 TAU RsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPK
P11047 S335 Sugiyama LAMC1 LAMB2 DCEKCLPFFNDRPWRRAtAEsASECLPCDCNGRsQECyFDP
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11168 S491 ELM SLC2A2 GLUT2 GVLLAFTLFTFFKVPETKGKsFEEIAAEFQKKsGsAHRPKA
P11168 S503 ELM SLC2A2 GLUT2 KVPETKGKsFEEIAAEFQKKsGsAHRPKAAVEMKFLGATET
P11168 S505 ELM SLC2A2 GLUT2 PETKGKsFEEIAAEFQKKsGsAHRPKAAVEMKFLGATETV_
P11473 S182 ELM VDR NR1I1 GGGSHPSRPNsRHtPSFSGDsSSSCSDHCITSSDMMDSSSF
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12814 S404 Sugiyama ACTN1 NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEt
P12931 S17 ELM SRC SRC1 ____MGSNKSKPKDAsQRRRsLEPAENVHGAGGGAFPAsQt
P12956 S477 Sugiyama XRCC6 G22P1 EQVGKMKAIVEKLRFtYRsDsFENPVLQQHFRNLEALALDL
P12956 S520 Sugiyama XRCC6 G22P1 PEQAVDLTLPKVEAMNKRLGsLVDEFKELVyPPDyNPEGKV
P13224 S191 ELM GP1BB LLCRLRRLRARARARAAARLsLtDPLVAERAGtDEs_____
P13569 S660 ELM CFTR ABCC7 FsSKLMGCDSFDQFSAERRNsILTETLHRFsLEGDAPVSWT
P13569 S700 ELM CFTR ABCC7 TEtKKQsFKQTGEFGEKRKNsILNPINsIRKFsIVQKTPLQ
P13569 S737 ELM CFTR ABCC7 TPLQMNGIEEDSDEPLERRLsLVPDSEQGEAILPRIsVIST
P13569 S753 ELM CFTR ABCC7 ERRLsLVPDSEQGEAILPRIsVISTGPTLQARRRQsVLNLM
P13569 S768 ELM CFTR ABCC7 ILPRIsVISTGPTLQARRRQsVLNLMTHSVNQGQNIHRKTT
P13569 S795 ELM CFTR ABCC7 HSVNQGQNIHRKTTAsTRKVsLAPQANLTELDIYsRRLsQE
P13569 S813 ELM CFTR ABCC7 KVsLAPQANLTELDIYsRRLsQEtGLEISEEINEEDLKECF
P13612 S1027 ELM ITGA4 CD49D RQYKsILQEENRRDsWsyINsKSNDD_______________
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13796 S5 ELM LCP1 PLS2 ________________MARGsVsDEEMMELREAFAKVDtDG
P13796 S7 ELM LCP1 PLS2 ______________MARGsVsDEEMMELREAFAKVDtDGNG
P13861 S99 ELM|Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14410 S7 SIGNOR|ELM SI ______________MARKKFsGLEISLIVLFVIVTIIAIAL
P14598 S303 ELM NCF1 NOXO2 SH3PXD1A sGQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDA
P14598 S320 ELM NCF1 NOXO2 SH3PXD1A PRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQAR
P14598 S328 ELM NCF1 NOXO2 SH3PXD1A AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14598 S348 ELM NCF1 NOXO2 SH3PXD1A sVRFLQQRRRQARPGPQsPGsPLEEERQtQRsKPQPAVPPR
P14598 S359 ELM NCF1 NOXO2 SH3PXD1A ARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILNRCs
P14598 S370 ELM NCF1 NOXO2 SH3PXD1A LEEERQtQRsKPQPAVPPRPsADLILNRCsESTKRKLASAV
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14859 S385 ELM POU2F1 OCT1 OTF1 PsALNsPGIEGLSRRRKKRtsIETNIRVALEKSFLENQKPT
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15056 S429 ELM BRAF BRAF1 RAFB1 SLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssDD
P15289 S372 Sugiyama ARSA TLDGFDLSPLLLGTGKSPRQsLFFYPSYPDEVRGVFAVRTG
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P15924 S2849 ELM DSP sRsGsRSGsRsGsRsGsRRGsFDAtGNssYsYSYSFSsssI
P16066 S529 ELM NPR1 ANPRA RVRWEDVEPSsLERHLRSAGsRLtLsGRGsNyGsLLtTEGQ
P16070 S45 Sugiyama CD44 LHR MDU2 MDU3 MIC4 NITCRFAGVFHVEKNGRYsIsRtEAADLCKAFNSTLPTMAQ
P16104 S20 Sugiyama H2AX H2AFX _MSGRGKTGGKARAKAKsRssRAGLQFPVGRVHRLLRKGHY
P16220 S119 SIGNOR CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16452 S248 ELM EPB42 E42P LPTPQTQATQEGALLNKRRGsVPILRQWLTGRGRPVYDGQA
P16949 S63 ELM STMN1 C1orf215 LAP18 OP18 KDLsLEEIQKKLEAAEERRKsHEAEVLKQLAEKREHEKEVL
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17542 S172 ELM TAL1 BHLHA17 SCL TCL5 FGEPDAFPMFTTNNRVKRRPsPYEMEITDGPHTKVVRRIFT
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17655 S369 ELM CAPN2 CANPL2 TSDTYKKWKLTKMDGNWRRGstAGGCRNYPNTFWMNPQYLI
P17655 T370 ELM CAPN2 CANPL2 SDTYKKWKLTKMDGNWRRGstAGGCRNYPNTFWMNPQYLIK
P17676 S288 ELM CEBPB TCF5 PP9092 DKHSDEYKIRRERNNIAVRKsRDKAKMRNLETQHKVLELTA
P17752 S58 ELM TPH1 TPH TPRH TRPH FQEKHVNLLHIESRKSKRRNsEFEIFVDCDINREQLNDIFH
P17812 T455 ELM CTPS1 CTPS DMPEHNPGQMGGTMRLGKRRtLFQTKNsVMRKLyGDADyLE
P17858 T773 ELM PFKL QYRISMAAYVsGELEHVTRRtLsMDKGF_____________
P17987 S35 Sugiyama TCP1 CCT1 CCTA EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P18505 S434 ELM GABRB1 YGRALDRHGVPSKGRIRRRAsQLKVKIPDLTDVNSIDKWSR
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19174 S1233 Sugiyama PLCG1 PLC1 PAKENGDLsPFsGtsLRERGsDASGQLFHGRAREGsFEsRy
P19174 S1248 ELM PLCG1 PLC1 LRERGsDASGQLFHGRAREGsFEsRyQQPFEDFRIsQEHLA
P19429 S23 ELM TNNI3 TNNC1 DGSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsA
P19429 S24 ELM TNNI3 TNNC1 GSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsAs
P19544 S365 ELM WT1 RKHTGEKPYQCDFKDCERRFsRSDQLKRHQRRHTGVKPFQC
P19544 S393 ELM WT1 HQRRHTGVKPFQCKTCQRKFsRSDHLKTHTRTHTGKTSEKP
P19838 S337 ELM NFKB1 KYKDINITKPAsVFVQLRRKsDLETSEPKPFLYYPEIKDKE
P20020 S1178 ELM ATP2B1 PMCA1 HIPLIDDTDAEDDAPTKRNSsPPPSPNKNNNAVDSGIHLTI
P20671 S20 Sugiyama H2AC7 H2AFG HIST1H2AD _MSGRGKQGGKARAKAKTRssRAGLQFPVGRVHRLLRKGNY
P20810 S366 Sugiyama CAST DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P21333 S2152 Sugiyama FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21731 S331 Sugiyama TBXA2R FRRAVLRRLQPRLsTRPRsLsLQPQLtQRSGLQ________
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22459 T601 SIGNOR KCNA4 KCNA4L QNAVSCPYLPSNLLKKFRSStSSSLGDKSEYLEMEEGVKES
P23771 S308 SIGNOR GATA3 GLYHKMNGQNRPLIKPKRRLsAARRAGTSCANCQTTTTTLW
P24385 S197 ELM CCND1 BCL1 PRAD1 IIRKHAQTFVALCATDVKFIsNPPSMVAAGSVVAAVQGLNL
P24385 S234 ELM CCND1 BCL1 PRAD1 GLNLRsPNNFLSYYRLTRFLsRVIKCDPDCLRACQEQIEAL
P24385 S90 ELM CCND1 BCL1 PRAD1 EQKCEEEVFPLAMNYLDRFLsLEPVKKSRLQLLGATCMFVA
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054 S2054 ELM APC DP2.5 sEDDLLQECISSAMPKKKKPsRLKGDNEKHsPRNMGGILGE
P25098 S685 ELM GRK2 ADRBK1 BARK BARK1 KNKPRsPVVELsKVPLVQRGsANGL________________
P25205 S374 Sugiyama MCM3 LLRYVLCTAPRAIPttGRGSsGVGLTAAVtTDQETGERRLE
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26038 T558 ELM MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26599 S16 ELM PTBP1 PTB _____MDGIVPDIAVGTKRGsDELFSTCVTNGPFIMSSNSA
P26641 S286 Sugiyama EEF1G EF1G PRO1608 CEQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVA
P26678 S16 ELM PLN PLB _____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFC
P27105 S10 ELM STOM BND7 EPB72 ___________MAEKRHTRDsEAQRLPDsFKDsPSKGLGPC
P27708 S1406 SIGNOR|ELM CAD EKNFELVINLSMRGAGGRRLssFVTKGYRTRRLAADFSVPL
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27815 S145 SIGNOR PDE4A DPDE2 sQAsPGLVLHAGAATSQRREsFLYRSDsDYDMsPKTMSRNs
P27815 S89 SIGNOR PDE4A DPDE2 DAMDTSDRPGLRTTRMsWPSsFHGTGTGSGGAGGGSSRRFE
P27986 S83 SIGNOR PIK3R1 GRB1 TGERGDFPGTYVEYIGRKKIsPPTPKPRPPRPLPVAPGSSK
P28340 S1064 Sugiyama POLD1 POLD LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK
P29401 S104 Sugiyama TKT AVWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGs
P29401 S305 Sugiyama TKT LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29401 S473 Sugiyama TKT AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P29474 S633 ELM NOS3 FNsISCSDPLVssWRRKRKEssNtDSAGALGTLRFCVFGLG
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30086 S139 Sugiyama PEBP1 PBP PEBP RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30301 S229 ELM MIP AQP0 IIGGGLGSLLYDFLLFPRLKsIsERLsVLKGAKPDVSNGQP
P30301 S231 ELM MIP AQP0 GGGLGSLLYDFLLFPRLKsIsERLsVLKGAKPDVSNGQPEV
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31323 S114 ELM PRKAR2B APADAGAFNAPVINRFTRRAsVCAEAyNPDEEEDDAESRII
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32245 S329 ELM MC4R LRKtFKEIICCYPLGGLCDLssRY_________________
P32245 S330 ELM MC4R RKtFKEIICCYPLGGLCDLssRY__________________
P32245 T312 ELM MC4R MCNSIIDPLIYALRSQELRKtFKEIICCYPLGGLCDLssRY
P32927 S601 ELM CSF2RB IL3RB IL5RB EKQASSFDFNGPyLGPPHSRsLPDILGQPEPPQEGGSQKSP
P33076 S1050 ELM CIITA MHC2TA LGAYKLAEALPSLAASLLRLsLYNNCICDVGAESLARVLPD
P33076 S834 ELM CIITA MHC2TA HEAEEAGIWQHVVQELPGRLsFLGTRLTPPDAHVLGKALEA
P33240 S310 Sugiyama CSTF2 VSMERGQVPMQDPRAAMQRGsLPANVPtPRGLLGDAPNDPR
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33993 S483 Sugiyama MCM7 CDC47 MCM2 EQQTISIAKAGILTTLNARCsILAAANPAyGRYNPRRsLEQ
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35236 S44 ELM PTPN7 QPPPEKTPAKKHVRLQERRGsNVALMLDVRSLGAVEPICsV
P35240 S518 ELM NF2 SCH FNLIGDSLSFDFKDTDMKRLsMEIEKEKVEYMEKSKHLQEQ
P35367 S398 ELM HRH1 sGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQLG
P35408 S222 ELM PTGER4 PTGER2 CNVLVCGALLRMHRQFMRRtsLGtEQHHAAAAASVASRGHP
P35408 S259 ELM PTGER4 PTGER2 RGHPAAsPALPRLSDFRRRRsFRRIAGAEIQMVILLIATSL
P35579 S1808 Sugiyama MYH9 KELKVKLQEMEGtVKsKYKAsITALEAKIAQLEEQLDNEtK
P35611 S408 ELM ADD1 ADDA GYRTGYPYRYPALREKSKKysDVEVPASVtGysFAsDGDsG
P35611 S436 ELM ADD1 ADDA VtGysFAsDGDsGtCsPLRHsFQKQQREKtRWLNSGRGDEA
P35611 S481 ELM ADD1 ADDA QNGssPKsKTKWTKEDGHRtstsAVPNLFVPLNTNPKEVQE
P35611 S59 ELM ADD1 ADDA RNMAPDLRQDFNMMEQKKRVsMILQsPAFCEELESMIQEQF
P35612 T55 ELM ADD2 ADDB RNRAADLRQDFNLMEQKKRVtMILQsPSFREELEGLIQEQM
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S148 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39748 S335 Sugiyama FEN1 RAD2 QFSEERIRSGVKRLSKsRQGsTQGRLDDFFKVTGsLssAKR
P39880 S1215 ELM CUX1 CUTL1 VEKLMDMKRMEKKAYMKRRHssVsDsQPCEPPsVGtEysQG
P40818 S718 Sugiyama USP8 KIAA0055 UBPY AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091 S107 Sugiyama EIF2S3 EIF2G KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P41161 S367 ELM ETV5 ERM GKVKQEPTMYREGPPYQRRGsLQLWQFLVTLLDDPANAHFI
P41181 S256 SIGNOR|ELM|PSP AQP2 VLKGLEPDTDWEEREVRRRQsVELHsPQsLPRGtKA_____
P41208 S170 ELM CETN2 CALT CEN2 DRDGDGEVsEQEFLRIMKKTsLY__________________
P42261 S863 ELM GRIA1 GLUA1 GLUH1 GLUR1 CLIPQQsINEAIRTStLPRNsGAGASSGGSGENGRVVSHDF
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43243 T150 Sugiyama MATR3 KIAA0723 EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P43694 S262 SIGNOR GATA4 GLYHKMNGINRPLIKPQRRLsASRRVGLSCANCQTTTTTLW
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46459 S207 Sugiyama NSF KAENSSLNLIGKAKTKENRQsIINPDWNFEKMGIGGLDKEF
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S230 Sugiyama RPL5 MSTP030 yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712 T416 Sugiyama PLA2G4A CPLA2 PLA2G4 AFSILFNRVLGVSGSQsRGstMEEELENIttKHIVsNDssD
P47736 S490 ELM RAP1GAP KIAA0474 RAP1GA1 LAKAAGIsLIVPGKsPtRKKsGPFGsRRssAIGIENIQEVQ
P47736 S499 ELM RAP1GAP KIAA0474 RAP1GA1 IVPGKsPtRKKsGPFGsRRssAIGIENIQEVQEKREsPPAG
P48050 S443 SIGNOR KCNJ4 IRK3 LDLERMQASLPLDNISYRREsAI__________________
P48058 S862 ELM GRIA4 GluA4 GLUR4 AEAKRMKLtFSEAIRNKARLsITGSVGENGRVLTPDCPKAV
P48436 S181 ELM SOX9 LRVQHKKDHPDYKYQPRRRKsVKNGQAEAEEATEQtHIsPN
P48436 S64 ELM SOX9 ENTRPQENTFPKGEPDLKKEsEEDKFPVCIREAVSQVLKGY
P48736 T1024 SIGNOR PIK3CG PHFQKFQDICVKAYLALRHHtNLLIILFSMMLMTGMPQLTS
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48764 S555 SIGNOR SLC9A3 NHE3 FHELNLKDAISYVAEGERRGsLAFIRsPsTDNVVNVDFTPR
P49327 S1997 Sugiyama FASN FAS DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49588 S237 Sugiyama AARS1 AARS LVFIQYNREADGILKPLPKKsIDtGMGLERLVsVLQNKMSN
P49588 S627 Sugiyama AARS1 AARS ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P49588 T240 Sugiyama AARS1 AARS IQYNREADGILKPLPKKsIDtGMGLERLVsVLQNKMSNYDT
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49736 S754 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 KLNQMDQDKVAKMYSDLRKEsMATGSIPITVRHIESMIRMA
P49768 S310 ELM PSEN1 AD3 PS1 PSNL1 STMVWLVNMAEGDPEAQRRVsKNsKyNAEstEREsQDtVAE
P49840 S21 ELM GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841 S9 SIGNOR|ELM GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50454 S139 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454 S141 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50552 S157 ELM VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50552 S239 ELM VASP GGAGAPGLAAAIAGAKLRKVsKQEEAsGGPTAPKAESGRSG
P50552 T278 ELM VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51858 S107 Sugiyama HDGF HMG1L2 WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG
P51858 S83 Sugiyama HDGF HMG1L2 LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P52179 S618 SIGNOR MYOM1 VSEPVAALDPAEKARLKSRPsAPWTGQIIVTEEEPSEGIVP
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52732 S36 Sugiyama KIF11 EG5 KNSL1 TRIP5 GKNIQVVVRCRPFNLAERKAsAHsIVECDPVRKEVSVRTGG
P52888 S643 ELM THOP1 FHTRFKQEGVLNSKVGMDYRsCILRPGGSEDASAMLRRFLG
P53365 S260 Sugiyama ARFIP2 POR1 TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396 S455 ELM|Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036 S358 Sugiyama PSMD4 MCB1 VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55064 S156 SIGNOR AQP5 LILTFQLALCIFASTDSRRTsPVGSPALSIGLSVTLGHLVG
P56524 S584 SIGNOR HDAC4 KIAA0288 EsDEEEAEPPREVEPGQRQPsEQELLFRQQALLLEQQRIHQ
P56537 S6 Sugiyama EIF6 EIF3A ITGB4BP OK/SW-cl.27 _______________MAVRAsFENNCEIGCFAKLTNTYCLV
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60983 S83 ELM GMFB ERQPRFIVYsYKYQHDDGRVsYPLCFIFSSPVGCKPEQQMM
P60983 T27 ELM GMFB VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61224 S179 ELM RAP1B OK/SW-cl.11 yDLVRQINRKTPVPGKARKKssCQLL_______________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61586 S188 ELM RHOA ARH12 ARHA RHO12 REVFEMAtRAALQARRGKKKsGCLVL_______________
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 S74 Sugiyama RPS11 tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S15 ELM H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI ______MPEPAKsAPAPKKGsKKAVTKAQKKDGKKRKRsRK
P62807 S33 ELM H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KGsKKAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDT
P62807 S37 ELM|Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62834 S180 ELM RAP1A KREV1 DLVRQINRKTPVEKKKPKKKsCLLL________________
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62937 S51 Sugiyama PPIA CYPA KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S58 ELM YWHAZ NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63252 S425 SIGNOR KCNJ2 IRK1 DIDLHNQASVPLEPRPLRREsEI__________________
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P78348 S479 ELM ASIC1 ACCN2 BNAC2 EVIKHKLCRRGKCQKEAKRSsADKGVALsLDDVKRHNPCEs
P78371 S60 Sugiyama CCT2 99D8.1 CCTB KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00536 S110 ELM CDK16 PCTAIRE1 PCTK1 sDEVQsPVRVRMRNHPPRKIstEDINKRLsLPADIRLPEGY
Q00536 S119 ELM CDK16 PCTAIRE1 PCTK1 VRMRNHPPRKIstEDINKRLsLPADIRLPEGYLEKLTLNsP
Q00536 S12 ELM CDK16 PCTAIRE1 PCTK1 _________MDRMKKIKRQLsMTLRGGRGIDKTNGAPEQIG
Q00536 S153 ELM CDK16 PCTAIRE1 PCTK1 KLTLNsPIFDKPLsRRLRRVsLsEIGFGKLETYIKLDKLGE
Q00587 S350 Sugiyama CDC42EP1 BORG5 CEP1 MSE55 HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01130 S121 PSP SRSF2 SFRS2 sRRGPPPRRYGGGGYGRRSRsPRRRRRsRsRSRSRSRSRSR
Q01130 S128 PSP SRSF2 SFRS2 RRYGGGGYGRRSRsPRRRRRsRsRSRSRSRSRSRSRYSRSK
Q01130 S130 PSP SRSF2 SFRS2 YGGGGYGRRSRsPRRRRRsRsRSRSRSRSRSRSRYSRSKSR
Q01130 S171 PSP SRSF2 SFRS2 SRTRSRSRSTSKSRSARRSKsKSSSVSRSRSRSRSRsRsRs
Q01970 S1105 ELM PLCB3 EMNEREKKELQKILDRKRHNsIsEAKMRDKHKKEAELTEIN
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04206 S276 Sugiyama RELA NFKB3 PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH
Q04206 S281 Sugiyama RELA NFKB3 sLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRHRIEEK
Q04695 S32 Sugiyama KRT17 SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q05209 S39 ELM PTPN12 sPDHNGEDNFARDFMRLRRLsTKYRTEKIyPTATGEKEENV
Q05209 S435 ELM PTPN12 LPGKNESTIEQIDKKLERNLsFEIKKVPLQEGPKsFDGNtL
Q05469 S853 ELM LIPE ELSGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKN
Q05469 S855 ELM LIPE SGRKSQKMSEPIAEPMRRsVsEAALAQPQGPLGTDSLKNLT
Q05469 S950 SIGNOR|ELM LIPE PMDRGLGVRAAFPEGFHPRRssQGATQMPLYSSPIVKNPFM
Q05469 S951 SIGNOR|ELM LIPE MDRGLGVRAAFPEGFHPRRssQGATQMPLYSSPIVKNPFMS
Q06124 S134 Sugiyama PTPN11 PTP2C SHPTP2 HGHLSGKEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTG
Q06124 S189 SIGNOR PTPN11 PTP2C SHPTP2 HVMIRCQELKYDVGGGERFDsLTDLVEHYKKNPMVETLGTV
Q06124 T73 SIGNOR PTPN11 PTP2C SHPTP2 HIKIQNTGDyYDLYGGEKFAtLAELVQYYMEHHGQLKEKNG
Q06210 S205 ELM GFPT1 GFAT GFPT FALVFKSVHFPGQAVGTRRGsPLLIGVRSEHKLSTDHIPIL
Q06210 S235 ELM GFPT1 GFAT GFPT HKLSTDHIPILYRTARTQIGsKFTRWGsQGERGKDKKGSCN
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q07002 S14 SIGNOR CDK18 PCTAIRE3 PCTK3 _______MIMNKMKNFKRRFsLSVPRTETIEESLAEFTEQF
Q07021 S106 Sugiyama C1QBP GC1QBP HABP1 SF2P32 LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG
Q07343 S133 SIGNOR|ELM PDE4B DPDE4 SSSAGLVLHATFPGHSQRREsFLYRsDsDYDLsPKAMSRNS
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07866 S445 Sugiyama KLC1 KLC KNS2 PIWMHAEEREECKGKQKDGTsFGEyGGWyKACKVDsPtVTT
Q07954 S4517 ELM LRP1 A2MR APR DKPTNFTNPVyATLYMGGHGsRHsLAsTDEKRELLGRGPED
Q07954 S4520 ELM LRP1 A2MR APR TNFTNPVyATLYMGGHGsRHsLAsTDEKRELLGRGPEDEIG
Q08211 S449 Sugiyama DHX9 DDX9 LKP NDH2 FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q08289 S514 ELM CACNB2 CACNLB2 MYSB NsQGSQGDQRTDRSAPIRsAsQAEEEPSVEPVKKSQHRSss
Q08289 S533 ELM CACNB2 CACNLB2 MYSB AsQAEEEPSVEPVKKSQHRSssSAPHHNHRSGTSRGLSRQE
Q08289 S534 ELM CACNB2 CACNLB2 MYSB sQAEEEPSVEPVKKSQHRSssSAPHHNHRSGTSRGLSRQEt
Q08289 T219 ELM CACNB2 CACNLB2 MYSB KSGGNSSSSLGDIVPSSRKstPPssAIDIDATGLDAEENDI
Q08493 S14 SIGNOR PDE4C DPDE1 _______MENLGVGEGAEACsRLSRSRGRHSMTRAPKHLWR
Q08495 S403 ELM DMTN DMT EPB49 sPEEFGKLALWKRNELKKKAsLF__________________
Q08499 S125 SIGNOR PDE4D DPDE3 RHRGYSDTERYLYCRAMDRTsYAVETGHRPGLKKSRMSWPS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q09470 S446 SIGNOR KCNA1 QLLHVSSPNLASDSDLSRRSsSTMSKSEYMEIEEDMNNSIA
Q12798 S170 ELM CETN1 CEN1 CETN DRDGDGEVNEEEFLRIMKKTsLY__________________
Q12802 S1565 ELM AKAP13 BRX HT31 LBC PANCSVLRSSMRSLsPFRRHsWGPGKNAASDAEMNHRSSMR
Q12802 S2733 ELM AKAP13 BRX HT31 LBC PSIAKsGsLDsELsVsPKRNsISRTHKDKGPFHILSSTSQT
Q12805 S196 Sugiyama EFEMP1 FBLN3 FBNL ECTAGTHNCRADQVCINLRGsFACQCPPGYQKRGEQCVDID
Q12809 S1137 ELM KCNH2 ERG ERG1 HERG CEELPPGAPELPQEGPTRRLsLPGQLGALTSQPLHRHGSDP
Q12809 S283 ELM KCNH2 ERG ERG1 HERG SSCSLARTRSRESCASVRRAssADDIEAMRAGVLPPPPRHA
Q12906 S20 Sugiyama ILF3 DRBF MPHOSPH4 NF90 _MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtER
Q12965 T939 Sugiyama MYO1E MYO1C SIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPP
Q12972 S178 ELM PPP1R8 ARD1 NIPP1 EEEtELDNLTEFNTAHNKRIsTLTIEEGNLDIQRPKRKRKN
Q12972 S199 ELM PPP1R8 ARD1 NIPP1 TLTIEEGNLDIQRPKRKRKNsRVtFsEDDEIINPEDVDPSV
Q13002 S697 ELM GRIK2 GLUR6 QTKIEYGAVEDGATMTFFKKsKISTYDKMWAFMSSRRQsVL
Q13002 S715 ELM GRIK2 GLUR6 KKsKISTYDKMWAFMSSRRQsVLVKSNEEGIQRVLTSDYAF
Q13098 S474 Sugiyama GPS1 COPS1 CSN1 MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___
Q13112 S409 Sugiyama CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 VLNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPss
Q13200 S361 SIGNOR PSMD2 TRAP2 EPKVPDDIyKtHLENNRFGGsGsQVDSARMNLASSFVNGFV
Q13224 S1166 SIGNOR GRIN2B NMDAR2B WEHVDLTDIYKERsDDFKRDsVSGGGPCTNRSHIKHGTGDK
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13370 S318 ELM PDE3B VsLGETAASYYGSCKIFRRPsLPCISREQMILWDWDLKQWY
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13526 S16 ELM PIN1 _____MADEEKLPPGWEKRMsRSSGRVyYFNHItNAsQWER
Q13576 T716 SIGNOR IQGAP2 KIQAFWKGYKQRKEYMHRRQtFIDNTDSIVKIQSWFRMATA
Q14103 S87 ELM HNRNPD AUF1 HNRPD KIDAsKNEEDEGHsNssPRHsEAAtAQREEWKMFIGGLSWD
Q14135 S59 Sugiyama VGLL4 KIAA0121 SALsSHRTGPPPIsPSKRKFsMEPGDEDLDCDNDHVSKMSR
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14157 S852 Sugiyama UBAP2L KIAA0144 NICE4 LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14203 S31 Sugiyama DCTN1 RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL
Q14204 S2384 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 FSEDVLSTDMIFNNFLARLRsIPLDEGEDEAQRRRKGKEDE
Q14344 T203 ELM GNA13 KLGEPDYIPSQQDILLARRPtKGIHEYDFEIKNVPFKMVDV
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14494 S599 ELM NFE2L1 HBZ17 NRF1 TCF11 MAPSALDSADLPPPSALKKGsKEKQADFLDKQMSRDEHRAR
Q14524 S36 SIGNOR SCN5A FtREsLAAIEKRMAEKQARGsTTLQEsREGLPEEEAPRPQL
Q14524 S525 SIGNOR SCN5A AMNHLsLTRGLsRTSMKPRssRGsIFTFRRRDLGsEADFAD
Q14524 S528 SIGNOR SCN5A HLsLTRGLsRTSMKPRssRGsIFTFRRRDLGsEADFADDEN
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14566 S498 Sugiyama MCM6 EQQTISITKAGVKATLNARTsILAAANPIsGHyDRSKSLKQ
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14749 S10 SIGNOR GNMT ___________MVDSVYRtRsLGVAAEGLPDQYADGEAARV
Q14847 S146 ELM|Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14847 S61 Sugiyama LASP1 MLN50 MKNYKGYEKKPYCNAHyPKQsFtMVADtPENLRLKQQSELQ
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14896 S275 SIGNOR|ELM MYBPC3 TVHEAMGTGDLDLLSAFRRTsLAGGGRRIsDSHEDTGILDF
Q14896 S284 SIGNOR|ELM MYBPC3 DLDLLSAFRRTsLAGGGRRIsDSHEDTGILDFSSLLKKRDs
Q14896 S304 SIGNOR|ELM MYBPC3 sDSHEDTGILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEI
Q14896 S311 SIGNOR|ELM MYBPC3 GILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEILRQAPPS
Q14978 S623 ELM NOLC1 KIAA0035 NS5ATP13 IKLQtPNtFPKRKKGEKRAssPFRRVREEEIEVDsRVADNs
Q15042 S340 Sugiyama RAB3GAP1 KIAA0066 RAB3GAP PQCLLGDFVTEFFKICRRKEsTDEILGRSAFEEEGKETADI
Q15052 S640 SIGNOR ARHGEF6 COOL2 KIAA0006 PIXA sKsPKTMKKFLHKRKTERKPsEEEyVIRKstAALEEDAQIL
Q15052 S684 SIGNOR ARHGEF6 COOL2 KIAA0006 PIXA EAYCTSANFQQGHGsstRKDsIPQVLLPEEEKLIIEETRsN
Q15084 S375 Sugiyama PDIA6 ERP5 P5 TXNDC7 GYPAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGst
Q15139 S742 SIGNOR PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q15149 S4386 Sugiyama PLEC PLEC1 ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15428 S153 Sugiyama SF3A2 SAP62 LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15746 S13 ELM MYLK MLCK MLCK1 MYLK1 ________MGDVKLVASSHIsKTsLsVDPSRVDSMPLTEAP
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q15835 S21 SIGNOR|ELM GRK1 RHOK MDFGsLETVVANSAFIAARGsFDGSSSQPSRDKKYLAKLKL
Q15942 S505 Sugiyama ZYX DQANRPHCVPDYHKQYAPRCsVCSEPIMPEPGRDETVRVVA
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16613 S205 ELM AANAT SNAT SLTFMELHCSLRGHPFLRRNsGC__________________
Q16613 T31 ELM AANAT SNAT PEAPRLPPGIPESPSCQRRHtLPASEFRCLTPEDAVSAFEI
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q16637 T25 Sugiyama SMN1 SMN SMNT; SMN2 SMNC sGGsGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDK
Q16777 S20 Sugiyama H2AC20 H2AFQ HIST2H2AC _MSGRGKQGGKARAKAKSRssRAGLQFPVGRVHRLLRKGNY
Q16821 S48 ELM PPP1R3A PP1G DEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsFAD
Q16821 S65 ELM PPP1R3A PP1G GsDsSEDIYLDTPSSGTRRVsFADSFGFNLVSVKEFDCWEL
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q58FF7 S488 Sugiyama HSP90AB3P HSP90BC TYGWTANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIM
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T2W1 S505 SIGNOR PDZK1 CAP70 NHERF3 PDZD1 KEGIVVESNHDSHMAKERAHsTASHSSSNSEDTEM______
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5T6F2 S856 Sugiyama UBAP2 KIAA1491 PVDyyGIPFAAPTALASRDGsLANNPYPGDVTKFGRGDSAS
Q676U5 S269 SIGNOR ATG16L1 APG16L UNQ9393/PRO34307 DHtEEtsPVRAISRAATKRLsQPAGGLLDsITNIFGRRsVs
Q68EM7 S702 SIGNOR ARHGAP17 RICH1 MSTP066 MSTP110 tGQPPGQPSAPSQLSAPRRysssLsPIQAPNHPPPQPPTQA
Q6FI13 S20 Sugiyama H2AC18 H2AFO HIST2H2AA HIST2H2AA3; H2AC19 HIST2H2AA4 _MsGRGKQGGKARAKAKSRssRAGLQFPVGRVHRLLRKGNY
Q6GYQ0 S861 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQM
Q6J4K2 S258 SIGNOR SLC8B1 NCKX6 NCLX SLC24A6 VFYVVTVILCTWIYQRQRRGsLFCPMPVTPEILsDsEEDRV
Q6P158 S54 Sugiyama DHX57 HGSGGGGGGGGGGGGGNRKAssRIWDDGDDFCIFSEsRRPs
Q6P158 S55 Sugiyama DHX57 GSGGGGGGGGGGGGGNRKAssRIWDDGDDFCIFSEsRRPsR
Q6P6C2 S96 Sugiyama ALKBH5 ABH5 OFOXD1 LQKEEEARKVKSGIRQMRLFsQDECAKIEARIDEVVSRAEK
Q6PIY7 S116 SIGNOR TENT2 GLD2 PAPD4 PHQEPtVVNQIVPLsGERRYsMPPLFHTHYVPDIVRCVPPF
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXD5 S719 Sugiyama SEZ6L2 PSK UNQ1903/PRO4349 CQKIMTCADPGEIANGHRTAsDAGFPVGSHVQYRCLPGYSL
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71RC2 S382 Sugiyama LARP4 PP13296 AAMNMGRPFQKNRVKPQFRssGGsEHstEGsVsLGDGQLNR
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7L7L0 S20 Sugiyama H2AC25 H2AW HIST3H2A _MsGRGKQGGKARAKAKSRSsRAGLQFPVGRVHRLLRKGNY
Q7Z418 S252 SIGNOR KCNK18 TRESK TRIK HALEKQNTLQLPPQAMERSNsCPELVLGRLsYsIIsNLDEV
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5L9 S455 Sugiyama IRF2BP2 AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9 S457 Sugiyama IRF2BP2 GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q7Z7G1 S331 Sugiyama CLNK MIST IGEYSRQAVEEAFMKENKDGsFLVRDCSTKSKEEPYVLAVF
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86UR1 S172 SIGNOR NOXA1 P51NOX WPEGSLNGLDSALDQVQRRGsLPPRQVPRGEVFRPHRWHLK
Q86UR1 S461 SIGNOR NOXA1 P51NOX CDGRIGIFPKCFVVPAGPRMsGAPGRLPRSQQGDQP_____
Q86VM9 S599 Sugiyama ZC3H18 NHN1 YSSYSSRSSRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsI
Q86VM9 S618 Sugiyama ZC3H18 NHN1 RsRsFsssPsPsPtPsPHRPsIRTKGEPAPPPGKAGEKSVK
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86W92 S794 Sugiyama PPFIBP1 KIAA1230 RAIQVLRINNFEPNCLRRRPsDENtIAPSEVQKWTNHRVME
Q8IUE6 S20 Sugiyama H2AC21 HIST2H2AB _MsGRGKQGGKARAKAKSRssRAGLQFPVGRVHRLLRKGNY
Q8IWQ3 T260 SIGNOR BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 PPDCQSLLRGMIEVDAARRLtLEHIQKHIWYIGGKNEPEPE
Q8IWX8 S705 Sugiyama CHERP DAN26 SCAF6 RLLAAVEAFYsPPSHDRPRNsEGWEQNGLyEFFRAKMRARR
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N130 S348 Sugiyama SLC34A3 NPT2C NPTIIC LAGSLLVLCGCLVLIVKLLNsVLRGRVAQVVRTVINADFPF
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N5S9 T108 ELM CAMKK1 CAMKKA AGPyAtGPAsHIsPRAWRRPtIEsHHVAIsDAEDCVQLNQY
Q8N983 S30 Sugiyama MRPL43 FLASVLHNGLGRYVQQLQRLsFSVSRDGASSRGAREFVERE
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NE71 S105 Sugiyama ABCF1 ABC50 KKDVDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKK
Q8TCD5 S182 Sugiyama NT5C DNT1 UMPH2 LFTCCHNRHLVLPPTRRRLLsWsDNWREILDSKRGAAQRE_
Q8TD08 S415 Sugiyama MAPK15 ERK7 ERK8 GHDPAEHESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKE
Q8TD08 T175 Sugiyama MAPK15 ERK7 ERK8 DFGLARSLGDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRY
Q8TD08 T421 Sugiyama MAPK15 ERK7 ERK8 HESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKEAPPLtL
Q8TD08 Y177 Sugiyama MAPK15 ERK7 ERK8 GLARSLGDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRYTL
Q8TD19 T333 Sugiyama NEK9 KIAA1995 NEK8 NERCC REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8TEW0 Y719 Sugiyama PARD3 PAR3 PAR3A PELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIM
Q8WTQ7 S23 SIGNOR|ELM GRK7 GPRK7 DMGALDNLIANTAYLQARKPsDCDSKELQRRRRsLALPGLQ
Q8WTQ7 S36 SIGNOR|ELM GRK7 GPRK7 YLQARKPsDCDSKELQRRRRsLALPGLQGCAELRQKLSLNF
Q8WUI4 S573 Sugiyama HDAC7 HDAC7A SRLQERGLRSQCECLRGRKAsLEELQSVHSERHVLLYGtNP
Q92547 S998 Sugiyama TOPBP1 KIAA0259 AQECKHLPESLYPHTYNPKMsLDIsAVQDGRLCNSRLLSAV
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92688 S134 Sugiyama ANP32B APRIL PHAPI2 CLKsLDLFNCEVtNLNDyREsVFKLLPQLTYLDGyDREDQE
Q92736 S2031 ELM RYR2 LDEDGSLDGNSDLTIRGRLLsLVEKVTYLKKKQAEKPVESD
Q92736 S2808 ELM RYR2 RIERTREGDSMALYNRTRRIsQTSQVsVDAAHGYSPRAIDM
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92777 S10 ELM SYN2 ___________MMNFLRRRLsDSSFIANLPNGYMTDLQRPE
Q92835 S27 Sugiyama INPP5D SHIP SHIP1 HGNITRSKAEELLSRTGKDGsFLVRAsESISRAYALCVLYR
Q92837 S188 SIGNOR FRAT1 CRRGWLRGAAASRRLQQRRGsQPETRTGDDDPHRLLQQLVL
Q92896 S1091 Sugiyama GLG1 CFR1 ESL1 MG160 CALDIKHHCAAITPGRGRQMsCLMEALEDKRVRLQPECKKR
Q92917 S27 SIGNOR GPKOW GPATC5 GPATCH5 T54 GVLPLTAAsTAPIsFGFtRtsARRRLADsGDGAGPsPEEKD
Q92917 T316 SIGNOR GPKOW GPATC5 GPATCH5 T54 EFDKNTLDLRQQNGTASSRKtLWNQELYIQQDNsERKRKHL
Q92934 S118 SIGNOR BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|ELM BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q92945 S333 Sugiyama KHSRP FUBP2 DRNEyGsRIGGGIDVPVPRHsVGVVIGRSGEMIKKIQNDAG
Q93034 S730 ELM CUL5 VACM1 LRILRTQEAIIQIMKMRKKIsNAQLQTELVEILKNMFLPQK
Q93052 S537 Sugiyama LPP DAGGLIHCIEDFHKKFAPRCsVCKEPIMPAPGQEETVRIVA
Q93077 S20 Sugiyama H2AC6 H2AFL HIST1H2AC _MsGRGKQGGKARAKAKSRssRAGLQFPVGRVHRLLRKGNY
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93100 S27 Sugiyama PHKB LTAEVSWKVLERRARTKRsGsVyEPLKsINLPRPDNETLWD
Q969F2 S223 SIGNOR NKD2 ELAEEPRVADRRLSAHVRRPstDPQPCSERGPYCVDENTER
Q96A00 T38 ELM PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96CN4 S493 Sugiyama EVI5L ETLGALREMQDKVLDMEKRNssLPDENNVAQLQEELKALKV
Q96CN4 S494 Sugiyama EVI5L TLGALREMQDKVLDMEKRNssLPDENNVAQLQEELKALKVR
Q96D15 S117 Sugiyama RCN3 UNQ239/PRO272 VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96D46 S462 Sugiyama NMD3 CGI-07 FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96KK5 S20 Sugiyama H2AC12 HIST1H2AH HIST1H2AI _MsGRGKQGGKARAKAKTRssRAGLQFPVGRVHRLLRKGNY
Q96P20 S295 SIGNOR NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 LIMSCCPDPNPPIHKIVRKPsRILFLMDGFDELQGAFDEHI
Q96PU5 S342 ELM NEDD4L KIAA0439 NEDL3 NGEQFsSLIQREPssRLRsCsVtDAVAEQGHLPPPSAPAGR
Q96PU5 S448 ELM NEDD4L KIAA0439 NEDL3 sATNSNNHLIEPQIRRPRsLssPtVTLSAPLEGAKDsPVRR
Q96PU5 T367 ELM NEDD4L KIAA0439 NEDL3 VAEQGHLPPPSAPAGRARsstVtGGEEPTPsVAYVHttPGL
Q96PX8 S695 SIGNOR SLITRK1 KIAA1910 LRRC12 UNQ233/PRO266 NGPYNADGAHRVYDCGSHSLsD___________________
Q96QV6 S20 Sugiyama H2AC1 H2AFR HIST1H2AA _MsGRGKQGGKARAKSKSRSsRAGLQFPVGRIHRLLRKGNY
Q96RR4 S100 SIGNOR CAMKK2 CAMKKB KIAA0787 EVPLDtsGSQARPHLSGRKLsLQERsQGGLAAGGsLDMNGR
Q96RR4 S495 SIGNOR CAMKK2 CAMKKB KIAA0787 VKHIPSLAtVILVKTMIRKRsFGNPFEGsRREERSLsAPGN
Q96RR4 S511 SIGNOR CAMKK2 CAMKKB KIAA0787 IRKRsFGNPFEGsRREERSLsAPGNLLTKKPTRECESLSEL
Q96SB3 S100 ELM PPP1R9B PPP1R6 LAEAPRASERGVRLsLPRASsLNENVDHSALLKLGTSVSER
Q96SB3 S94 ELM PPP1R9B PPP1R6 AGGGAGLAEAPRASERGVRLsLPRASsLNENVDHSALLKLG
Q96T58 S1268 Sugiyama SPEN KIAA0929 MINT SHARP SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP
Q99259 T91 SIGNOR GAD1 GAD GAD67 QSSKNLLSCENSDRDARFRRtETDFSNLFARDLLPAKNGEE
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99878 S20 Sugiyama H2AC14 H2AFE HIST1H2AJ _MsGRGKQGGKARAKAKTRssRAGLQFPVGRVHRLLRKGNY
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BTC0 S1456 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BTM1 S20 Sugiyama H2AJ H2AFJ _MSGRGKQGGKVRAKAKSRSsRAGLQFPVGRVHRLLRKGNY
Q9BWD1 S226 Sugiyama ACAT2 ACTL LVstRKGLIEVKtDEFPRHGsNIEAMSKLKPYFLTDGTGTV
Q9BXS5 S305 Sugiyama AP1M1 CLTNM KHSHSRIEYMIKAKSQFKRRstANNVEIHIPVPNDADsPKF
Q9BXS5 T306 Sugiyama AP1M1 CLTNM HSHSRIEYMIKAKSQFKRRstANNVEIHIPVPNDADsPKFK
Q9BY41 S39 ELM HDAC8 HDACL1 CDA07 IYSPEYVSMCDSLAKIPKRAsMVHSLIEAYALHKQMRIVKP
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6 S706 SIGNOR PRKD2 PKD2 HSPC187 DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQ
Q9BZL6 S710 SIGNOR PRKD2 PKD2 HSPC187 QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLLNQGyNR
Q9BZL6 S876 SIGNOR PRKD2 PKD2 HSPC187 DLGGACPPQDHDMQGLAERIsVL__________________
Q9C0C2 S882 Sugiyama TNKS1BP1 KIAA1741 TAB182 LQDQEFGKRDsLGtyssRDVsLGDWEFGKRDsLGAyAsQDA
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9GZT3 S15 Sugiyama SLIRP C14orf156 DC23 DC50 PD04872 ______MAASAARGAAALRRsINQPVAFVRRIPWTAASSQL
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H3N1 S270 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H3Q1 S309 Sugiyama CDC42EP4 BORG4 CEP4 AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD
Q9H3Z4 S10 Sugiyama DNAJC5 CLN4 ___________MADQRQRsLstsGEsLyHVLGLDKNATSDD
Q9H6T3 S480 Sugiyama RPAP3 NNPINLANVIAATGTTSKKNssQDDLFPTsDtPRAKVLKIE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HAU0 S410 Sugiyama PLEKHA5 KIAA1686 PEPP2 NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HBA0 S162 SIGNOR TRPV4 VRL2 VROAC PPPILKVFNRPILFDIVSRGsTADLDGLLPFLLtHKKRLTD
Q9HBA0 S189 SIGNOR TRPV4 VRL2 VROAC LLPFLLtHKKRLTDEEFREPsTGKTCLPKALLNLSNGRNDT
Q9HBA0 T175 SIGNOR TRPV4 VRL2 VROAC FDIVSRGsTADLDGLLPFLLtHKKRLTDEEFREPsTGKTCL
Q9HCR9 S117 SIGNOR PDE11A PLSPSWAGGSRGDGNLQRRAsQKELRKSFARSKAIHVNRtY
Q9HCR9 S162 SIGNOR PDE11A TSRAQEPLSSVRRRALLRKAsSLPPTTAHILSALLESRVNL
Q9NP61 S366 Sugiyama ARFGAP3 ARFGAP1 DDsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKD
Q9NPD3 S240 Sugiyama EXOSC4 RRP41 SKI6 AARDVHTLLDRVVRQHVREAsILLGD_______________
Q9NQY0 S248 Sugiyama BIN3 HSDEQRERENEAKLSELRALsIVADD_______________
Q9NRA8 S353 Sugiyama EIF4ENIF1 SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NRL3 T338 Sugiyama STRN4 ZIN EFDFLGSGEDGEGAPDPRRCtVDGsPHELESRRVKLQGILA
Q9NXH3 T58 ELM PPP1R14D GBPI ESKSHPDSSKIPRSRRPSRLtVKYDRGQLQRWLEMEQWVDA
Q9NYK5 S57 Sugiyama MRPL39 C21orf92 MRPL5 RPML5 MSTP003 PRED22 PTELTEMRNDLFNKEKARQLsLTPRTEKIEVKHVGKTDPGT
Q9NYV4 S1053 Sugiyama CDK12 CRK7 CRKRS KIAA0904 LPHWQDCHELWSKKRRRQRQsGVVVEEPPPSKTSRKETtsG
Q9NZN8 S242 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9P265 S203 Sugiyama DIP2B KIAA1463 stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBT2 S507 Sugiyama UBA2 SAE2 UBLE1B HRIHFB2115 GTILISsEEGETEANNHKKLsEFGIRNGSRLQADDFLQDYT
Q9UD71 T34 SIGNOR PPP1R1B DARPP32 PAPPSQLDPRQVEMIRRRRPtPAMLFRLsEHssPEEEAsPH
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2 S335 Sugiyama NDRG3 YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UH77 S433 SIGNOR KLHL3 KIAA1129 AYSYKTNEWFFVAPMNTRRSsVGVGVVEGKLYAVGGYDGAS
Q9UH99 S116 ELM SUN2 FRIGG KIAA0668 RAB5IP UNC84B GEDLRVRRRRGtGGsEssRAsGLVGRKATEDFLGsSSGYss
Q9UH99 S12 ELM SUN2 FRIGG KIAA0668 RAB5IP UNC84B _________MSRRSQRLtRysQGDDDGssssGGSSVAGsQs
Q9UH99 S54 ELM SUN2 FRIGG KIAA0668 RAB5IP UNC84B LFKDsPLRTLKRKSSNMKRLsPAPQLGPssDAHTSYYSESL
Q9UHD1 S200 Sugiyama CHORDC1 CHP1 SGVPIFHEGMKYWSCCRRKtsDFNtFLAQEGCtKGKHMWTK
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UJY1 S24 SIGNOR HSPB8 CRYAC E2IG1 HSP22 PP1629 GQMPFSCHYPsRLRRDPFRDsPLsSRLLDDGFGMDPFPDDL
Q9UJY1 S57 SIGNOR HSPB8 CRYAC E2IG1 HSP22 PP1629 MDPFPDDLTASWPDWALPRLsSAWPGtLRSGMVPRGPTATA
Q9UL62 S794 SIGNOR TRPC5 TRP5 STELSQRDDNNDGSGGARAKsKsVSFNLGCKKKTCHGPPLI
Q9UL62 S796 SIGNOR TRPC5 TRP5 ELSQRDDNNDGSGGARAKsKsVSFNLGCKKKTCHGPPLIRT
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0 S185 Sugiyama LIMCH1 KIAA1102 DDIEsPKRSIRDsGyIDCWDsERsDsLsPPRHGRDDsFDsL
Q9UPQ0 S190 Sugiyama LIMCH1 KIAA1102 PKRSIRDsGyIDCWDsERsDsLsPPRHGRDDsFDsLDsFGs
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S1101 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF
Q9UQ35 S1455 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y230 S43 Sugiyama RUVBL2 INO80J TIP48 TIP49B CGI-46 GAHSHIRGLGLDDALEPRQAsQGMVGQLAARRAAGVVLEMI
Q9Y259 S39 SIGNOR CHKB CHETK CHKL AKDGLQQSKCPDTTPKRRRAssLSRDAERRAYQWCREYLGG
Q9Y259 S40 SIGNOR CHKB CHETK CHKL KDGLQQSKCPDTTPKRRRAssLSRDAERRAYQWCREYLGGA
Q9Y266 S298 Sugiyama NUDC DLDsEtRsMVEKMMYDQRQKsMGLPtsDEQKKQEILKKFMD
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2 S52 Sugiyama CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y4H2 S1174 Sugiyama IRS2 stttVtPVsPsFAHNPKRHNsAsVENVsLRKssEGGVGVGP
Q9Y6E0 T18 ELM STK24 MST3 STK3 ___MDSRAQLWGLALNKRRAtLPHPGGSTNLKADPEELFTK
Q9Y6R1 S1026 SIGNOR|ELM SLC4A4 NBC NBC1 NBCE1 IPEKDKKKKEDEKKKKKKKGsLDsDNDDsDCPYSEKVPSIK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 4.123425e-10 9.385 0 0
Chromatin organization R-HSA-4839726 1.708129e-09 8.767 0 0
G alpha (12/13) signalling events R-HSA-416482 5.473910e-08 7.262 0 0
NRAGE signals death through JNK R-HSA-193648 6.684672e-08 7.175 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.052651e-06 5.978 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.636719e-06 5.786 0 0
Cell Cycle R-HSA-1640170 2.412921e-06 5.617 0 0
Cell Cycle Checkpoints R-HSA-69620 2.471179e-06 5.607 0 0
Signal Transduction R-HSA-162582 2.986367e-06 5.525 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.356899e-06 5.078 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.328797e-05 4.877 0 0
Meiotic synapsis R-HSA-1221632 1.400401e-05 4.854 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.351126e-05 4.869 0 0
Cellular Senescence R-HSA-2559583 2.431308e-05 4.614 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.295821e-05 4.367 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.671502e-05 4.331 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.902566e-05 4.310 0 0
HATs acetylate histones R-HSA-3214847 5.164777e-05 4.287 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.956712e-05 4.225 0 0
Apoptotic execution phase R-HSA-75153 8.292982e-05 4.081 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.652358e-05 4.015 0 0
Gene expression (Transcription) R-HSA-74160 1.086241e-04 3.964 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.173022e-04 3.931 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.489491e-04 3.827 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.817073e-04 3.741 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.355440e-04 3.628 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.766577e-04 3.558 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.868413e-04 3.542 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.956066e-04 3.529 0 0
Regulation of TP53 Activity R-HSA-5633007 3.028203e-04 3.519 0 0
Death Receptor Signaling R-HSA-73887 3.134421e-04 3.504 0 0
Cell Cycle, Mitotic R-HSA-69278 3.239377e-04 3.490 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.828790e-04 3.417 0 0
Activation of RAC1 R-HSA-428540 4.197234e-04 3.377 0 0
RNA Polymerase II Transcription R-HSA-73857 4.329963e-04 3.364 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.768178e-04 3.322 0 0
HDACs deacetylate histones R-HSA-3214815 5.143756e-04 3.289 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.097129e-04 3.215 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.123041e-04 3.213 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.005481e-04 3.221 0 0
DNA Double Strand Break Response R-HSA-5693606 6.091372e-04 3.215 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.268214e-04 3.139 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.879940e-04 3.052 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.900374e-04 3.051 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.056626e-04 3.043 0 0
DNA methylation R-HSA-5334118 9.413016e-04 3.026 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.451101e-04 3.025 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.128583e-03 2.947 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.128583e-03 2.947 0 0
HDMs demethylate histones R-HSA-3214842 1.152875e-03 2.938 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.152712e-03 2.938 0 0
RAF activation R-HSA-5673000 1.185347e-03 2.926 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.390953e-03 2.857 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.399268e-03 2.854 0 0
Meiosis R-HSA-1500620 1.536792e-03 2.813 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.642512e-03 2.784 0 0
Packaging Of Telomere Ends R-HSA-171306 1.870958e-03 2.728 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.930601e-03 2.714 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.981395e-03 2.703 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.039296e-03 2.691 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.179971e-03 2.662 0 0
Axon guidance R-HSA-422475 2.311675e-03 2.636 1 0
Diseases of programmed cell death R-HSA-9645723 2.542520e-03 2.595 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.553148e-03 2.593 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.882408e-03 2.540 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.917586e-03 2.535 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.044237e-03 2.517 0 0
M Phase R-HSA-68886 3.314570e-03 2.480 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.402224e-03 2.468 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.479168e-03 2.459 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.712711e-03 2.430 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.712711e-03 2.430 0 0
Homology Directed Repair R-HSA-5693538 3.672684e-03 2.435 0 0
Interleukin-37 signaling R-HSA-9008059 3.593639e-03 2.444 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.776845e-03 2.423 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.786009e-03 2.422 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.971701e-03 2.401 0 0
Reproduction R-HSA-1474165 4.005525e-03 2.397 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.050154e-03 2.393 0 0
Nucleosome assembly R-HSA-774815 4.050154e-03 2.393 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.747238e-03 2.324 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.747238e-03 2.324 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.747238e-03 2.324 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.810878e-03 2.318 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.747238e-03 2.324 0 0
Signaling by RAS mutants R-HSA-6802949 4.747238e-03 2.324 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.482405e-03 2.348 0 0
Generic Transcription Pathway R-HSA-212436 4.830063e-03 2.316 0 0
mRNA 3'-end processing R-HSA-72187 4.914538e-03 2.309 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.914538e-03 2.309 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.378028e-03 2.269 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.290380e-03 2.277 0 0
G2/M Checkpoints R-HSA-69481 5.083775e-03 2.294 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.320556e-03 2.274 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.656760e-03 2.247 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.679868e-03 2.246 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.788703e-03 2.237 1 0
Mitotic Prometaphase R-HSA-68877 5.942863e-03 2.226 0 0
MTOR signalling R-HSA-165159 6.210924e-03 2.207 0 0
Nervous system development R-HSA-9675108 6.146115e-03 2.211 1 0
mRNA Splicing - Major Pathway R-HSA-72163 6.383071e-03 2.195 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.499579e-03 2.187 0 0
Kinesins R-HSA-983189 6.554680e-03 2.183 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.662692e-03 2.176 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.127948e-03 2.147 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.127948e-03 2.147 0 0
Defective pyroptosis R-HSA-9710421 7.254593e-03 2.139 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.272146e-03 2.138 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.306449e-03 2.136 0 0
Signaling by ROBO receptors R-HSA-376176 7.331773e-03 2.135 1 0
Germ layer formation at gastrulation R-HSA-9754189 7.408619e-03 2.130 0 0
Rap1 signalling R-HSA-392517 7.408619e-03 2.130 1 1
RNA Polymerase II Transcription Termination R-HSA-73856 7.465797e-03 2.127 0 0
mRNA Splicing R-HSA-72172 8.392195e-03 2.076 0 0
Netrin-1 signaling R-HSA-373752 8.432295e-03 2.074 0 0
Mitotic Prophase R-HSA-68875 8.170883e-03 2.088 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.403155e-03 2.076 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.140279e-03 2.089 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.432295e-03 2.074 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.479652e-03 2.072 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.312071e-03 2.031 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.747751e-03 2.011 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.136186e-02 1.945 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.136186e-02 1.945 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.136186e-02 1.945 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.136186e-02 1.945 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.136186e-02 1.945 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.087377e-02 1.964 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.121631e-02 1.950 0 0
ESR-mediated signaling R-HSA-8939211 1.108366e-02 1.955 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.069082e-02 1.971 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.089789e-02 1.963 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.149272e-02 1.940 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.184283e-02 1.927 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.201792e-02 1.920 0 0
RET signaling R-HSA-8853659 1.252563e-02 1.902 1 1
RNA Polymerase I Transcription R-HSA-73864 1.258846e-02 1.900 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.365129e-02 1.865 0 0
Cell junction organization R-HSA-446728 1.430458e-02 1.845 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.417893e-02 1.848 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.439581e-02 1.842 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.439581e-02 1.842 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.459027e-02 1.836 0 0
Cleavage of the damaged purine R-HSA-110331 1.459027e-02 1.836 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.463510e-02 1.835 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.463510e-02 1.835 0 0
NGF-stimulated transcription R-HSA-9031628 1.471080e-02 1.832 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.477296e-02 1.831 0 0
Depyrimidination R-HSA-73928 1.477296e-02 1.831 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.487431e-02 1.828 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.567073e-02 1.805 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.626150e-02 1.789 0 0
Signaling by Hippo R-HSA-2028269 1.489840e-02 1.827 0 0
Cell-Cell communication R-HSA-1500931 1.502941e-02 1.823 0 0
Specification of primordial germ cells R-HSA-9827857 1.489840e-02 1.827 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.652188e-02 1.782 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.690128e-02 1.772 0 0
Depurination R-HSA-73927 1.690128e-02 1.772 0 0
Centrosome maturation R-HSA-380287 1.802460e-02 1.744 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.923297e-02 1.716 1 1
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.982726e-02 1.703 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.982726e-02 1.703 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.990311e-02 1.701 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.993137e-02 1.700 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.065819e-02 1.685 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.267307e-02 1.644 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.267307e-02 1.644 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.267307e-02 1.644 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.267307e-02 1.644 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.267307e-02 1.644 0 0
DCC mediated attractive signaling R-HSA-418885 2.402390e-02 1.619 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.402390e-02 1.619 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.405783e-02 1.619 0 0
Signaling by APC mutants R-HSA-4839744 2.409003e-02 1.618 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.409003e-02 1.618 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.409003e-02 1.618 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.409003e-02 1.618 0 0
G2/M Transition R-HSA-69275 2.429831e-02 1.614 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.547439e-02 1.594 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.945613e-02 1.531 0 0
Regulation of PTEN localization R-HSA-8948747 2.945613e-02 1.531 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.945613e-02 1.531 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.736177e-02 1.563 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.736177e-02 1.563 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.904555e-02 1.537 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.904555e-02 1.537 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.652204e-02 1.576 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.666394e-02 1.574 0 0
MAP2K and MAPK activation R-HSA-5674135 2.893062e-02 1.539 0 0
Signaling by WNT R-HSA-195721 2.676627e-02 1.572 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.733351e-02 1.563 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.658927e-02 1.575 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.658927e-02 1.575 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.857086e-02 1.544 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.946458e-02 1.531 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.976261e-02 1.526 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.080247e-02 1.511 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.080247e-02 1.511 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.104872e-02 1.508 0 0
Signaling by AXIN mutants R-HSA-4839735 3.104872e-02 1.508 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.104872e-02 1.508 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.282511e-02 1.484 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.282511e-02 1.484 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.282511e-02 1.484 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.282511e-02 1.484 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.366106e-02 1.473 0 0
TRP channels R-HSA-3295583 3.399962e-02 1.469 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.417557e-02 1.466 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.561695e-02 1.448 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.914940e-02 1.407 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.950640e-02 1.403 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 4.734476e-02 1.325 0 0
mTORC1-mediated signalling R-HSA-166208 4.549803e-02 1.342 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.549803e-02 1.342 0 0
Meiotic recombination R-HSA-912446 4.365190e-02 1.360 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.612158e-02 1.336 0 0
Apoptosis R-HSA-109581 4.745958e-02 1.324 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.754967e-02 1.323 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.754967e-02 1.323 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.848076e-02 1.314 0 0
Signaling by NTRKs R-HSA-166520 4.942157e-02 1.306 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.980531e-02 1.303 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.980531e-02 1.303 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.127764e-02 1.290 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.127764e-02 1.290 0 0
Polo-like kinase mediated events R-HSA-156711 5.208489e-02 1.283 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.417086e-02 1.266 1 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.873575e-02 1.231 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.888662e-02 1.230 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.942828e-02 1.226 0 0
Neurodegenerative Diseases R-HSA-8863678 6.107021e-02 1.214 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.107021e-02 1.214 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.195532e-02 1.208 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.475473e-02 1.189 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.475473e-02 1.189 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.475473e-02 1.189 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.599042e-02 1.181 0 0
Signaling by MAPK mutants R-HSA-9652817 6.599042e-02 1.181 0 0
Chromosome Maintenance R-HSA-73886 6.907967e-02 1.161 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.020162e-02 1.154 0 0
Signaling by WNT in cancer R-HSA-4791275 7.569750e-02 1.121 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.599042e-02 1.181 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.053728e-02 1.152 0 0
MAPK family signaling cascades R-HSA-5683057 7.628865e-02 1.118 1 0
Semaphorin interactions R-HSA-373755 7.120368e-02 1.147 0 0
Programmed Cell Death R-HSA-5357801 6.939075e-02 1.159 0 0
Formation of the nephric duct R-HSA-9830364 6.994056e-02 1.155 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.342931e-02 1.134 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.817334e-02 1.107 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.817334e-02 1.107 0 0
Potassium transport channels R-HSA-1296067 7.817334e-02 1.107 0 0
Regulation of TP53 Expression R-HSA-6804754 7.817334e-02 1.107 0 0
Separation of Sister Chromatids R-HSA-2467813 7.823667e-02 1.107 0 0
Telomere Maintenance R-HSA-157579 7.924194e-02 1.101 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.946231e-02 1.100 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.989089e-02 1.098 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.181622e-02 1.087 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.262116e-02 1.083 0 0
Differentiation of T cells R-HSA-9945266 8.335959e-02 1.079 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.335959e-02 1.079 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.335959e-02 1.079 1 1
Cardiogenesis R-HSA-9733709 8.474277e-02 1.072 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 8.660318e-02 1.062 0 0
Ub-specific processing proteases R-HSA-5689880 8.787550e-02 1.056 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.797670e-02 1.056 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.797670e-02 1.056 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.797670e-02 1.056 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.986210e-02 1.046 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.986210e-02 1.046 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.986210e-02 1.046 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.085349e-01 0.964 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.085349e-01 0.964 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.085349e-01 0.964 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.085349e-01 0.964 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.085349e-01 0.964 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.085349e-01 0.964 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.085349e-01 0.964 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.732358e-02 1.012 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.436744e-02 1.025 0 0
HIV elongation arrest and recovery R-HSA-167287 1.009021e-01 0.996 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.009021e-01 0.996 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.439374e-02 1.025 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.046448e-01 0.980 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.046448e-01 0.980 0 0
HIV Transcription Elongation R-HSA-167169 9.701084e-02 1.013 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.701084e-02 1.013 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.701084e-02 1.013 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.839431e-02 1.007 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.982745e-02 1.001 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.732358e-02 1.012 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.046448e-01 0.980 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.071509e-02 1.042 0 0
Signaling by ERBB4 R-HSA-1236394 9.648927e-02 1.016 0 0
Cell-cell junction organization R-HSA-421270 9.468889e-02 1.024 0 0
Protein ubiquitination R-HSA-8852135 1.035087e-01 0.985 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.095598e-01 0.960 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.095598e-01 0.960 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.095598e-01 0.960 0 0
SOS-mediated signalling R-HSA-112412 1.095598e-01 0.960 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.095598e-01 0.960 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.095598e-01 0.960 0 0
Deubiquitination R-HSA-5688426 1.099872e-01 0.959 0 0
Mitotic Anaphase R-HSA-68882 1.107890e-01 0.956 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.126457e-01 0.948 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.128004e-01 0.948 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.135331e-01 0.945 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.141077e-01 0.943 1 1
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.145057e-01 0.941 0 0
Repression of WNT target genes R-HSA-4641265 1.148228e-01 0.940 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.152074e-01 0.939 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.154868e-01 0.937 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.158165e-01 0.936 0 0
Co-stimulation by CD28 R-HSA-389356 1.166159e-01 0.933 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.172229e-01 0.931 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.208816e-01 0.918 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.208816e-01 0.918 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.230994e-01 0.910 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.250747e-01 0.903 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.275315e-01 0.894 0 0
Ephrin signaling R-HSA-3928664 1.284952e-01 0.891 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.284952e-01 0.891 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.284952e-01 0.891 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.284952e-01 0.891 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.052956e-01 0.688 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.052956e-01 0.688 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.052956e-01 0.688 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.052956e-01 0.688 0 0
Regulation of gap junction activity R-HSA-191650 1.520785e-01 0.818 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.520785e-01 0.818 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.520785e-01 0.818 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.915589e-01 0.535 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.915589e-01 0.535 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.915589e-01 0.535 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.915589e-01 0.535 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.915589e-01 0.535 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.915589e-01 0.535 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.915589e-01 0.535 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.915589e-01 0.535 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.915589e-01 0.535 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.915589e-01 0.535 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.915589e-01 0.535 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.915589e-01 0.535 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.915589e-01 0.535 0 0
Intestinal infectious diseases R-HSA-8942233 2.915589e-01 0.535 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.927023e-01 0.715 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.927023e-01 0.715 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.927023e-01 0.715 0 0
IRS activation R-HSA-74713 1.927023e-01 0.715 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.927023e-01 0.715 0 0
Type I hemidesmosome assembly R-HSA-446107 1.345635e-01 0.871 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.345635e-01 0.871 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 1.345635e-01 0.871 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 1.345635e-01 0.871 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.345635e-01 0.871 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.345635e-01 0.871 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.345000e-01 0.630 1 1
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.345000e-01 0.630 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.684630e-01 0.434 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.684630e-01 0.434 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.684630e-01 0.434 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.684630e-01 0.434 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.684630e-01 0.434 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.684630e-01 0.434 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.684630e-01 0.434 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.684630e-01 0.434 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.684630e-01 0.434 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.684630e-01 0.434 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.684630e-01 0.434 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.684630e-01 0.434 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.344085e-01 0.872 0 0
PI3K/AKT activation R-HSA-198203 1.894747e-01 0.722 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.894747e-01 0.722 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.767387e-01 0.558 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.187694e-01 0.660 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.187694e-01 0.660 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.771863e-01 0.752 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.771863e-01 0.752 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.771863e-01 0.752 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.771863e-01 0.752 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.455861e-01 0.837 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.455861e-01 0.837 0 0
Deadenylation of mRNA R-HSA-429947 1.352183e-01 0.869 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.635880e-01 0.786 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.635880e-01 0.786 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.635880e-01 0.786 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.635880e-01 0.786 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.635880e-01 0.786 0 0
Phosphorylation of the APC/C R-HSA-176412 2.000985e-01 0.699 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.000985e-01 0.699 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.489006e-01 0.604 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.489006e-01 0.604 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.188305e-01 0.496 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.188305e-01 0.496 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.188305e-01 0.496 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.188305e-01 0.496 0 0
Netrin mediated repulsion signals R-HSA-418886 3.188305e-01 0.496 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.188305e-01 0.496 0 0
Axonal growth stimulation R-HSA-209563 4.370229e-01 0.359 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.370229e-01 0.359 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 4.370229e-01 0.359 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 4.370229e-01 0.359 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.370229e-01 0.359 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.370229e-01 0.359 0 0
Invadopodia formation R-HSA-8941237 4.370229e-01 0.359 0 0
Tight junction interactions R-HSA-420029 1.504257e-01 0.823 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.824236e-01 0.739 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.238331e-01 0.650 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.238331e-01 0.650 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.663580e-01 0.779 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.795979e-01 0.553 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.795979e-01 0.553 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.795979e-01 0.553 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.829657e-01 0.738 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.603101e-01 0.443 1 1
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.603101e-01 0.443 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.662286e-01 0.779 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.222623e-01 0.653 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.001956e-01 0.699 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.001956e-01 0.699 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.106118e-01 0.508 0 0
Striated Muscle Contraction R-HSA-390522 1.811343e-01 0.742 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.430914e-01 0.614 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.644087e-01 0.578 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.985269e-01 0.525 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.981435e-01 0.303 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.981435e-01 0.303 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.981435e-01 0.303 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.981435e-01 0.303 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 4.981435e-01 0.303 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.981435e-01 0.303 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.981435e-01 0.303 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 4.981435e-01 0.303 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.861254e-01 0.543 0 0
Erythropoietin activates RAS R-HSA-9027284 3.727058e-01 0.429 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.727058e-01 0.429 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.727058e-01 0.429 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.727058e-01 0.429 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.400671e-01 0.356 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.304084e-01 0.481 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.304084e-01 0.481 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.304084e-01 0.481 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.034025e-01 0.394 0 0
Metabolism of non-coding RNA R-HSA-194441 2.462791e-01 0.609 0 0
snRNP Assembly R-HSA-191859 2.462791e-01 0.609 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.756056e-01 0.425 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.756056e-01 0.425 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.528064e-01 0.452 0 0
Transcription of the HIV genome R-HSA-167172 2.623218e-01 0.581 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.343118e-01 0.476 1 1
Signaling by Erythropoietin R-HSA-9006335 3.752681e-01 0.426 0 0
Phase 2 - plateau phase R-HSA-5576893 4.336483e-01 0.363 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.778622e-01 0.321 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.526316e-01 0.258 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.526316e-01 0.258 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.526316e-01 0.258 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.526316e-01 0.258 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.526316e-01 0.258 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.526316e-01 0.258 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.526316e-01 0.258 0 0
Defective F9 activation R-HSA-9673221 5.526316e-01 0.258 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.977181e-01 0.400 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.633081e-01 0.334 0 0
Trafficking of AMPA receptors R-HSA-399719 4.200851e-01 0.377 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.200851e-01 0.377 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.200851e-01 0.377 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.140537e-01 0.289 0 0
ERKs are inactivated R-HSA-202670 5.140537e-01 0.289 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.423023e-01 0.354 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.264519e-01 0.370 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.643080e-01 0.333 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.204304e-01 0.284 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.204304e-01 0.284 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.485444e-01 0.261 0 0
Polymerase switching R-HSA-69091 5.485444e-01 0.261 0 0
Leading Strand Synthesis R-HSA-69109 5.485444e-01 0.261 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 5.485444e-01 0.261 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 5.485444e-01 0.261 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.012066e-01 0.221 0 0
PKB-mediated events R-HSA-109703 6.012066e-01 0.221 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.012066e-01 0.221 0 0
Cam-PDE 1 activation R-HSA-111957 6.012066e-01 0.221 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.012066e-01 0.221 0 0
PDE3B signalling R-HSA-165160 6.012066e-01 0.221 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.012066e-01 0.221 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.012066e-01 0.221 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.012066e-01 0.221 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.012066e-01 0.221 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.012066e-01 0.221 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.012066e-01 0.221 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.556962e-01 0.341 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.556962e-01 0.341 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.285118e-01 0.277 0 0
Telomere Extension By Telomerase R-HSA-171319 5.481654e-01 0.261 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.481654e-01 0.261 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.491524e-01 0.260 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.301449e-01 0.276 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.740753e-01 0.241 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.517667e-01 0.258 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.708357e-01 0.243 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.687803e-01 0.245 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.687803e-01 0.245 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.994494e-01 0.222 0 0
Removal of the Flap Intermediate R-HSA-69166 6.122268e-01 0.213 0 0
STAT5 Activation R-HSA-9645135 6.445099e-01 0.191 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.445099e-01 0.191 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.238093e-01 0.205 0 0
FGFR2 alternative splicing R-HSA-6803529 6.238093e-01 0.205 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.238093e-01 0.205 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.413949e-01 0.193 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.413949e-01 0.193 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.413949e-01 0.193 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.413949e-01 0.193 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.890634e-01 0.230 0 0
EPH-Ephrin signaling R-HSA-2682334 1.352201e-01 0.869 0 0
RNA Polymerase III Transcription R-HSA-74158 5.491524e-01 0.260 0 0
Integrin signaling R-HSA-354192 1.662286e-01 0.779 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.643080e-01 0.333 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.081538e-01 0.511 0 0
DAP12 signaling R-HSA-2424491 3.977181e-01 0.400 0 0
Downstream signal transduction R-HSA-186763 1.381667e-01 0.860 0 0
Hedgehog 'off' state R-HSA-5610787 2.142467e-01 0.669 1 1
Transcriptional regulation by RUNX3 R-HSA-8878159 1.858644e-01 0.731 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.731886e-01 0.564 0 0
Formation of definitive endoderm R-HSA-9823730 1.635880e-01 0.786 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.977181e-01 0.400 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.457048e-01 0.610 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.756056e-01 0.425 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.644668e-01 0.784 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.477201e-01 0.261 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.355993e-01 0.868 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.355993e-01 0.868 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.681416e-01 0.572 0 0
Regulated Necrosis R-HSA-5218859 5.086875e-01 0.294 0 0
FOXO-mediated transcription R-HSA-9614085 2.879673e-01 0.541 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.355993e-01 0.868 0 0
HSF1-dependent transactivation R-HSA-3371571 5.169706e-01 0.287 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.074490e-01 0.390 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.605353e-01 0.337 0 0
Aggrephagy R-HSA-9646399 6.269550e-01 0.203 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.413949e-01 0.193 0 0
Frs2-mediated activation R-HSA-170968 1.344085e-01 0.872 0 0
MHC class II antigen presentation R-HSA-2132295 6.085530e-01 0.216 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.356778e-01 0.197 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.066229e-01 0.685 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.613052e-01 0.792 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.861254e-01 0.543 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.613052e-01 0.792 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.345000e-01 0.630 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.188305e-01 0.496 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.482443e-01 0.605 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.965751e-01 0.706 0 0
Nuclear RNA decay R-HSA-9930044 2.936400e-01 0.532 0 0
Regulation of CDH11 function R-HSA-9762292 4.400671e-01 0.356 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.271769e-01 0.644 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.012583e-01 0.397 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.736965e-01 0.324 0 0
DNA strand elongation R-HSA-69190 6.348158e-01 0.197 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.492527e-01 0.603 0 0
Pyroptosis R-HSA-5620971 5.481654e-01 0.261 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.719220e-01 0.243 0 0
Myogenesis R-HSA-525793 5.010372e-01 0.300 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.423023e-01 0.354 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.520830e-01 0.598 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.133631e-01 0.504 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.520785e-01 0.818 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.613052e-01 0.792 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.795979e-01 0.553 0 0
Adrenoceptors R-HSA-390696 3.603101e-01 0.443 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.603101e-01 0.443 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.008146e-01 0.397 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.936400e-01 0.532 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.526316e-01 0.258 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.972551e-01 0.401 0 0
Formation of axial mesoderm R-HSA-9796292 5.812771e-01 0.236 0 0
DARPP-32 events R-HSA-180024 5.708357e-01 0.243 1 1
Telomere C-strand synthesis initiation R-HSA-174430 6.413949e-01 0.193 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.226711e-01 0.491 1 0
Interleukin-2 signaling R-HSA-9020558 2.187694e-01 0.660 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.377807e-01 0.359 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.081538e-01 0.511 0 0
Signal attenuation R-HSA-74749 1.894747e-01 0.722 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.064952e-01 0.685 0 0
Long-term potentiation R-HSA-9620244 2.861254e-01 0.543 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.485444e-01 0.261 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.526337e-01 0.453 0 0
Signaling by PDGF R-HSA-186797 5.531987e-01 0.257 0 0
Generation of second messenger molecules R-HSA-202433 4.539022e-01 0.343 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.651973e-01 0.437 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.878725e-01 0.312 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.395151e-01 0.268 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.345571e-01 0.871 0 0
S Phase R-HSA-69242 4.458931e-01 0.351 0 0
Prolonged ERK activation events R-HSA-169893 2.000985e-01 0.699 0 0
Neurexins and neuroligins R-HSA-6794361 2.568194e-01 0.590 0 0
Insulin receptor signalling cascade R-HSA-74751 5.846691e-01 0.233 0 0
Calcineurin activates NFAT R-HSA-2025928 1.613052e-01 0.792 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.345000e-01 0.630 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.552420e-01 0.809 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.188305e-01 0.496 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.603101e-01 0.443 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.008146e-01 0.397 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.936400e-01 0.532 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.936400e-01 0.532 0 0
Formation of the posterior neural plate R-HSA-9832991 4.778622e-01 0.321 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.633081e-01 0.334 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.140537e-01 0.289 0 0
IRS-mediated signalling R-HSA-112399 4.707422e-01 0.327 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.126151e-01 0.290 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.812771e-01 0.236 1 1
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.445099e-01 0.191 0 0
Hydrolysis of LPE R-HSA-1483152 6.445099e-01 0.191 0 0
Signaling by Hedgehog R-HSA-5358351 5.135887e-01 0.289 1 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.853360e-01 0.414 0 0
IGF1R signaling cascade R-HSA-2428924 4.454126e-01 0.351 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.860452e-01 0.313 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.769046e-01 0.558 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.518841e-01 0.345 1 1
Signaling by FGFR in disease R-HSA-1226099 4.679719e-01 0.330 0 0
Glycogen metabolism R-HSA-8982491 4.539022e-01 0.343 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.619117e-01 0.441 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.349095e-01 0.629 0 0
Cilium Assembly R-HSA-5617833 3.684484e-01 0.434 0 0
Signaling by VEGF R-HSA-194138 1.927607e-01 0.715 1 0
Signaling by SCF-KIT R-HSA-1433557 2.366244e-01 0.626 0 0
Post NMDA receptor activation events R-HSA-438064 1.474223e-01 0.831 1 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.338938e-01 0.198 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.520785e-01 0.818 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.927023e-01 0.715 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.345000e-01 0.630 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.936400e-01 0.532 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.400671e-01 0.356 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.012066e-01 0.221 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.122268e-01 0.213 0 0
p38MAPK events R-HSA-171007 6.413949e-01 0.193 0 0
TCR signaling R-HSA-202403 5.376588e-01 0.269 0 0
Hedgehog 'on' state R-HSA-5632684 3.027825e-01 0.519 0 0
Signalling to ERKs R-HSA-187687 2.125116e-01 0.673 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.286637e-01 0.202 0 0
RMTs methylate histone arginines R-HSA-3214858 1.497582e-01 0.825 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.812473e-01 0.318 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.812473e-01 0.318 0 0
Ion homeostasis R-HSA-5578775 2.066229e-01 0.685 0 0
Signaling by NODAL R-HSA-1181150 5.477201e-01 0.261 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.613796e-01 0.336 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.767387e-01 0.558 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.161296e-01 0.500 0 0
Regulation of signaling by CBL R-HSA-912631 5.204304e-01 0.284 0 0
PTEN Regulation R-HSA-6807070 5.244703e-01 0.280 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.445099e-01 0.191 0 0
Calmodulin induced events R-HSA-111933 2.289026e-01 0.640 1 0
MyD88-independent TLR4 cascade R-HSA-166166 5.376588e-01 0.269 0 0
PLC beta mediated events R-HSA-112043 2.740884e-01 0.562 1 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.188305e-01 0.496 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.631735e-01 0.580 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.485444e-01 0.261 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.376588e-01 0.269 0 0
Developmental Biology R-HSA-1266738 4.849571e-01 0.314 1 0
CaM pathway R-HSA-111997 2.289026e-01 0.640 1 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.518841e-01 0.345 0 0
Biotin transport and metabolism R-HSA-196780 6.413949e-01 0.193 0 0
DAG and IP3 signaling R-HSA-1489509 2.681416e-01 0.572 1 0
Regulation of TP53 Degradation R-HSA-6804757 2.289026e-01 0.640 0 0
Specification of the neural plate border R-HSA-9834899 5.204304e-01 0.284 0 0
Opioid Signalling R-HSA-111885 5.604516e-01 0.251 1 0
Assembly of the pre-replicative complex R-HSA-68867 1.430584e-01 0.844 0 0
G0 and Early G1 R-HSA-1538133 1.518948e-01 0.818 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.561206e-01 0.255 1 1
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.575865e-01 0.340 0 0
Muscle contraction R-HSA-397014 1.710307e-01 0.767 0 0
Inhibition of PKR R-HSA-169131 2.052956e-01 0.688 0 0
MTF1 activates gene expression R-HSA-5660489 1.520785e-01 0.818 0 0
Interleukin-33 signaling R-HSA-9014843 3.684630e-01 0.434 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.344085e-01 0.872 0 0
MET interacts with TNS proteins R-HSA-8875513 4.370229e-01 0.359 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.370229e-01 0.359 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.370229e-01 0.359 0 0
Signaling by LTK R-HSA-9842663 2.795979e-01 0.553 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.430914e-01 0.614 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.780143e-01 0.750 0 0
Unwinding of DNA R-HSA-176974 4.008146e-01 0.397 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.981435e-01 0.303 0 0
Transmission across Electrical Synapses R-HSA-112307 4.981435e-01 0.303 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.981435e-01 0.303 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.400671e-01 0.356 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.034025e-01 0.394 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.756056e-01 0.425 0 0
Notch-HLH transcription pathway R-HSA-350054 4.012583e-01 0.397 0 0
Disorders of Developmental Biology R-HSA-9675151 4.336483e-01 0.363 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.336483e-01 0.363 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.526316e-01 0.258 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.526316e-01 0.258 0 0
Suppression of autophagy R-HSA-9636569 5.526316e-01 0.258 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.936949e-01 0.405 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.180778e-01 0.379 0 0
Phosphorylation of Emi1 R-HSA-176417 6.012066e-01 0.221 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.012066e-01 0.221 0 0
Synthesis of PS R-HSA-1483101 6.012066e-01 0.221 0 0
Formation of the Editosome R-HSA-75094 6.012066e-01 0.221 0 0
PI3K Cascade R-HSA-109704 4.992109e-01 0.302 0 0
Signalling to RAS R-HSA-167044 5.740753e-01 0.241 0 0
Platelet calcium homeostasis R-HSA-418360 5.708357e-01 0.243 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.693471e-01 0.245 0 0
cGMP effects R-HSA-418457 6.122268e-01 0.213 0 0
EGFR downregulation R-HSA-182971 6.141898e-01 0.212 0 0
Autophagy R-HSA-9612973 5.293382e-01 0.276 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.086462e-01 0.216 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.324595e-01 0.199 0 0
Cardiac conduction R-HSA-5576891 3.344438e-01 0.476 0 0
Ca-dependent events R-HSA-111996 3.526337e-01 0.453 1 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.379016e-01 0.195 0 0
Interleukin-2 family signaling R-HSA-451927 1.780143e-01 0.750 0 0
DNA Repair R-HSA-73894 1.839527e-01 0.735 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.972435e-01 0.224 0 0
Adherens junctions interactions R-HSA-418990 1.597670e-01 0.797 0 0
Interleukin-1 family signaling R-HSA-446652 1.811092e-01 0.742 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.122268e-01 0.213 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.972435e-01 0.224 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.972435e-01 0.224 0 0
Adaptive Immune System R-HSA-1280218 6.086048e-01 0.216 1 0
FLT3 signaling in disease R-HSA-9682385 5.491524e-01 0.260 0 0
p75NTR signals via NF-kB R-HSA-193639 6.413949e-01 0.193 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.771863e-01 0.752 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.643080e-01 0.333 0 0
FLT3 Signaling R-HSA-9607240 1.920333e-01 0.717 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.041846e-01 0.297 0 0
G-protein mediated events R-HSA-112040 3.620742e-01 0.441 1 0
Smooth Muscle Contraction R-HSA-445355 5.517667e-01 0.258 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.336483e-01 0.363 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.336483e-01 0.363 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 5.485444e-01 0.261 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.481654e-01 0.261 0 0
Rab regulation of trafficking R-HSA-9007101 5.398965e-01 0.268 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.708357e-01 0.243 0 0
Neurofascin interactions R-HSA-447043 6.445099e-01 0.191 0 0
Activation of BH3-only proteins R-HSA-114452 3.977181e-01 0.400 0 0
Signaling by EGFR R-HSA-177929 2.066229e-01 0.685 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.922672e-01 0.308 0 0
Macroautophagy R-HSA-1632852 5.460341e-01 0.263 0 0
Interleukin-1 processing R-HSA-448706 1.613052e-01 0.792 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.345000e-01 0.630 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.106118e-01 0.508 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.106118e-01 0.508 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.008146e-01 0.397 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.400671e-01 0.356 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.860452e-01 0.313 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.485444e-01 0.261 0 0
Pervasive developmental disorders R-HSA-9005895 5.485444e-01 0.261 0 0
Disorders of Nervous System Development R-HSA-9697154 5.485444e-01 0.261 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.012066e-01 0.221 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.012066e-01 0.221 0 0
Heme signaling R-HSA-9707616 5.531987e-01 0.257 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.208678e-01 0.207 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.399033e-01 0.268 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.644124e-01 0.438 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.994494e-01 0.222 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.017894e-01 0.221 0 0
Regulation of KIT signaling R-HSA-1433559 3.417156e-01 0.466 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.589097e-01 0.445 0 0
TGFBR3 expression R-HSA-9839394 4.766826e-01 0.322 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.574591e-01 0.447 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.731886e-01 0.564 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.662286e-01 0.779 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.936400e-01 0.532 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.633081e-01 0.334 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.980782e-01 0.526 0 0
Glycolysis R-HSA-70171 3.996484e-01 0.398 1 0
Co-inhibition by PD-1 R-HSA-389948 6.193686e-01 0.208 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.850768e-01 0.233 0 0
Kidney development R-HSA-9830369 3.620742e-01 0.441 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.074490e-01 0.390 0 0
PI Metabolism R-HSA-1483255 3.226711e-01 0.491 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.915589e-01 0.535 0 0
DSCAM interactions R-HSA-376172 3.684630e-01 0.434 0 0
Synthesis of PI R-HSA-1483226 2.187694e-01 0.660 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.370229e-01 0.359 0 0
Alpha-defensins R-HSA-1462054 3.603101e-01 0.443 0 0
ARMS-mediated activation R-HSA-170984 4.008146e-01 0.397 0 0
Sensory perception of sour taste R-HSA-9729555 4.981435e-01 0.303 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.034025e-01 0.394 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.336483e-01 0.363 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.526316e-01 0.258 0 0
PTK6 Down-Regulation R-HSA-8849472 5.526316e-01 0.258 0 0
Interleukin-36 pathway R-HSA-9014826 5.526316e-01 0.258 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.339399e-01 0.363 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.643080e-01 0.333 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.012066e-01 0.221 0 0
Creatine metabolism R-HSA-71288 5.477201e-01 0.261 0 0
Signaling by ALK in cancer R-HSA-9700206 2.980782e-01 0.526 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.994494e-01 0.222 0 0
MAP kinase activation R-HSA-450294 5.370974e-01 0.270 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.708357e-01 0.243 0 0
Signaling by ALK R-HSA-201556 1.644668e-01 0.784 0 0
Protein hydroxylation R-HSA-9629569 5.477201e-01 0.261 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.855799e-01 0.232 1 0
SARS-CoV-1-host interactions R-HSA-9692914 4.881201e-01 0.311 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.248834e-01 0.280 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.767387e-01 0.558 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.936400e-01 0.532 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.936400e-01 0.532 0 0
Nuclear import of Rev protein R-HSA-180746 5.074621e-01 0.295 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.442169e-01 0.191 0 0
Signaling by NOTCH1 R-HSA-1980143 4.978579e-01 0.303 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.215995e-01 0.206 0 0
Glucose metabolism R-HSA-70326 4.370515e-01 0.359 1 0
Spry regulation of FGF signaling R-HSA-1295596 6.413949e-01 0.193 0 0
Formation of the anterior neural plate R-HSA-9823739 3.727058e-01 0.429 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.740753e-01 0.241 0 0
Diseases of DNA repair R-HSA-9675135 2.843345e-01 0.546 0 0
Signaling by TGFBR3 R-HSA-9839373 5.867906e-01 0.232 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.188305e-01 0.496 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.370229e-01 0.359 0 0
Interleukin-18 signaling R-HSA-9012546 3.603101e-01 0.443 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.008146e-01 0.397 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.981435e-01 0.303 0 0
Dopamine receptors R-HSA-390651 4.981435e-01 0.303 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.526316e-01 0.258 0 0
NrCAM interactions R-HSA-447038 5.526316e-01 0.258 0 0
Stimuli-sensing channels R-HSA-2672351 2.251764e-01 0.647 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.537868e-01 0.343 0 0
Estrogen biosynthesis R-HSA-193144 5.485444e-01 0.261 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.012066e-01 0.221 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.012066e-01 0.221 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.012066e-01 0.221 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.812771e-01 0.236 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.122268e-01 0.213 0 0
CREB phosphorylation R-HSA-199920 6.445099e-01 0.191 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.445099e-01 0.191 0 0
NADPH regeneration R-HSA-389542 6.445099e-01 0.191 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.269550e-01 0.203 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.269550e-01 0.203 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.406893e-01 0.193 0 0
Amyloid fiber formation R-HSA-977225 2.297276e-01 0.639 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.896527e-01 0.538 0 0
Signaling by Interleukins R-HSA-449147 2.258091e-01 0.646 0 0
Interleukin-7 signaling R-HSA-1266695 2.861254e-01 0.543 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.081538e-01 0.511 0 0
Nephrin family interactions R-HSA-373753 5.477201e-01 0.261 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.812473e-01 0.318 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.790285e-01 0.320 0 0
OAS antiviral response R-HSA-8983711 2.795979e-01 0.553 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.603101e-01 0.443 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.008146e-01 0.397 0 0
Lipophagy R-HSA-9613354 4.008146e-01 0.397 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.860452e-01 0.313 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.890634e-01 0.230 0 0
Signal regulatory protein family interactions R-HSA-391160 6.122268e-01 0.213 0 0
Lipid particle organization R-HSA-8964572 6.445099e-01 0.191 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.413949e-01 0.193 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.413949e-01 0.193 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.731886e-01 0.564 0 0
GAB1 signalosome R-HSA-180292 4.922672e-01 0.308 0 0
G1/S-Specific Transcription R-HSA-69205 5.491524e-01 0.260 0 0
Interleukin-15 signaling R-HSA-8983432 5.485444e-01 0.261 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.400671e-01 0.356 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.238093e-01 0.205 0 0
Base Excision Repair R-HSA-73884 3.525821e-01 0.453 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.756056e-01 0.425 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.140537e-01 0.289 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.790285e-01 0.320 0 0
Platelet sensitization by LDL R-HSA-432142 2.731886e-01 0.564 0 0
Maturation of nucleoprotein R-HSA-9683610 5.812771e-01 0.236 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.000026e-01 0.222 0 0
Signaling by Leptin R-HSA-2586552 4.400671e-01 0.356 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.204304e-01 0.284 0 0
Gene Silencing by RNA R-HSA-211000 3.946475e-01 0.404 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.450879e-01 0.190 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.450879e-01 0.190 0 0
Formation of the ureteric bud R-HSA-9830674 6.471336e-01 0.189 0 0
Syndecan interactions R-HSA-3000170 6.471336e-01 0.189 0 0
Potential therapeutics for SARS R-HSA-9679191 6.481855e-01 0.188 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.547136e-01 0.184 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.547136e-01 0.184 0 0
G-protein beta:gamma signalling R-HSA-397795 6.547136e-01 0.184 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.589490e-01 0.181 0 0
HCMV Early Events R-HSA-9609690 6.623716e-01 0.179 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.626571e-01 0.179 1 1
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.626571e-01 0.179 1 1
SLC-mediated transport of neurotransmitters R-HSA-442660 6.626571e-01 0.179 0 0
Signaling by ERBB2 R-HSA-1227986 6.636457e-01 0.178 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.636457e-01 0.178 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.636457e-01 0.178 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.636457e-01 0.178 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.636457e-01 0.178 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.636457e-01 0.178 0 0
Sensory processing of sound R-HSA-9659379 6.672299e-01 0.176 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.688032e-01 0.175 0 0
Killing mechanisms R-HSA-9664420 6.688032e-01 0.175 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.688032e-01 0.175 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.688032e-01 0.175 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 6.688032e-01 0.175 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.688032e-01 0.175 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.688032e-01 0.175 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.688032e-01 0.175 0 0
TNFs bind their physiological receptors R-HSA-5669034 6.694110e-01 0.174 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.705210e-01 0.174 0 0
Interleukin-17 signaling R-HSA-448424 6.720858e-01 0.173 0 0
DNA Replication R-HSA-69306 6.764641e-01 0.170 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.769523e-01 0.169 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.796513e-01 0.168 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.796513e-01 0.168 1 1
Integration of energy metabolism R-HSA-163685 6.800322e-01 0.167 1 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.831133e-01 0.166 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.831133e-01 0.166 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.831133e-01 0.166 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.831133e-01 0.166 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.831133e-01 0.166 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.831133e-01 0.166 0 0
Glycoprotein hormones R-HSA-209822 6.831133e-01 0.166 0 0
CHL1 interactions R-HSA-447041 6.831133e-01 0.166 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.831133e-01 0.166 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.831133e-01 0.166 0 0
Cellular response to heat stress R-HSA-3371556 6.847028e-01 0.164 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.855103e-01 0.164 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.855103e-01 0.164 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.858993e-01 0.164 0 0
Metabolism of RNA R-HSA-8953854 6.879840e-01 0.162 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.906396e-01 0.161 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.906396e-01 0.161 0 0
tRNA processing in the nucleus R-HSA-6784531 6.922637e-01 0.160 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.922767e-01 0.160 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.922767e-01 0.160 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.944901e-01 0.158 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.944901e-01 0.158 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.944901e-01 0.158 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.944901e-01 0.158 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.944901e-01 0.158 0 0
Passive transport by Aquaporins R-HSA-432047 6.944901e-01 0.158 0 0
Synthesis of PG R-HSA-1483148 6.944901e-01 0.158 0 0
Response to metal ions R-HSA-5660526 6.944901e-01 0.158 0 0
Signaling by FGFR4 R-HSA-5654743 6.960622e-01 0.157 0 0
TBC/RABGAPs R-HSA-8854214 6.960622e-01 0.157 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.985859e-01 0.156 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.985859e-01 0.156 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.059662e-01 0.151 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.059662e-01 0.151 0 0
Signaling by PTK6 R-HSA-8848021 7.059662e-01 0.151 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.059662e-01 0.151 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.082063e-01 0.150 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.108252e-01 0.148 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.108252e-01 0.148 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.108252e-01 0.148 0 0
Ca2+ pathway R-HSA-4086398 7.113073e-01 0.148 0 0
G1 Phase R-HSA-69236 7.118850e-01 0.148 0 0
Cyclin D associated events in G1 R-HSA-69231 7.118850e-01 0.148 0 0
DAP12 interactions R-HSA-2172127 7.118850e-01 0.148 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.143407e-01 0.146 0 0
Translation initiation complex formation R-HSA-72649 7.152159e-01 0.146 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.166568e-01 0.145 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.175268e-01 0.144 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.175268e-01 0.144 0 0
Activation of RAS in B cells R-HSA-1169092 7.175268e-01 0.144 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.175268e-01 0.144 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.175268e-01 0.144 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.175268e-01 0.144 0 0
Regulation by c-FLIP R-HSA-3371378 7.175268e-01 0.144 0 0
Co-stimulation by ICOS R-HSA-9927354 7.175268e-01 0.144 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.175268e-01 0.144 0 0
Dimerization of procaspase-8 R-HSA-69416 7.175268e-01 0.144 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.175268e-01 0.144 0 0
Sodium/Proton exchangers R-HSA-425986 7.175268e-01 0.144 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.175268e-01 0.144 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.175268e-01 0.144 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.185060e-01 0.144 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.185060e-01 0.144 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.185060e-01 0.144 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.185060e-01 0.144 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.185060e-01 0.144 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.185060e-01 0.144 0 0
Circadian clock R-HSA-9909396 7.205190e-01 0.142 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.224366e-01 0.141 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.242191e-01 0.140 1 0
GPVI-mediated activation cascade R-HSA-114604 7.268337e-01 0.139 0 0
Glycosphingolipid transport R-HSA-9845576 7.268337e-01 0.139 0 0
RUNX2 regulates bone development R-HSA-8941326 7.268337e-01 0.139 0 0
Signaling by FGFR3 R-HSA-5654741 7.271175e-01 0.138 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.271175e-01 0.138 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.271175e-01 0.138 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.299800e-01 0.137 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.299800e-01 0.137 0 0
Signaling by TGFB family members R-HSA-9006936 7.373053e-01 0.132 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.395280e-01 0.131 1 1
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.409109e-01 0.130 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.409109e-01 0.130 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.409109e-01 0.130 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.409109e-01 0.130 0 0
Apoptotic factor-mediated response R-HSA-111471 7.409109e-01 0.130 0 0
PKA activation R-HSA-163615 7.409109e-01 0.130 1 1
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.409109e-01 0.130 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.409109e-01 0.130 0 0
PKA activation in glucagon signalling R-HSA-164378 7.409109e-01 0.130 1 1
Mismatch Repair R-HSA-5358508 7.409109e-01 0.130 0 0
Tie2 Signaling R-HSA-210993 7.409109e-01 0.130 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.409109e-01 0.130 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.417605e-01 0.130 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.417605e-01 0.130 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.425899e-01 0.129 0 0
TNF signaling R-HSA-75893 7.425899e-01 0.129 0 0
Interleukin-12 signaling R-HSA-9020591 7.473143e-01 0.126 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.481224e-01 0.126 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.481224e-01 0.126 0 0
Interleukin-21 signaling R-HSA-9020958 7.482048e-01 0.126 0 0
WNT mediated activation of DVL R-HSA-201688 7.482048e-01 0.126 0 0
CASP8 activity is inhibited R-HSA-5218900 7.482048e-01 0.126 0 0
ALK mutants bind TKIs R-HSA-9700645 7.482048e-01 0.126 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.482048e-01 0.126 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.482048e-01 0.126 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.482048e-01 0.126 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.482048e-01 0.126 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.482048e-01 0.126 0 0
mRNA Editing R-HSA-75072 7.482048e-01 0.126 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.482048e-01 0.126 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.482048e-01 0.126 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.482048e-01 0.126 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.482048e-01 0.126 0 0
Ion channel transport R-HSA-983712 7.524365e-01 0.124 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.558171e-01 0.122 0 0
Recycling pathway of L1 R-HSA-437239 7.558171e-01 0.122 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.559815e-01 0.121 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.559815e-01 0.121 0 0
MET promotes cell motility R-HSA-8875878 7.584085e-01 0.120 0 0
Inositol phosphate metabolism R-HSA-1483249 7.611495e-01 0.119 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.617715e-01 0.118 0 0
The NLRP3 inflammasome R-HSA-844456 7.617715e-01 0.118 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.617715e-01 0.118 0 0
Maturation of nucleoprotein R-HSA-9694631 7.617715e-01 0.118 0 0
mRNA Capping R-HSA-72086 7.652749e-01 0.116 0 0
Late endosomal microautophagy R-HSA-9615710 7.652749e-01 0.116 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.652749e-01 0.116 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.652749e-01 0.116 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.652749e-01 0.116 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.652749e-01 0.116 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.660585e-01 0.116 0 0
Toll-like Receptor Cascades R-HSA-168898 7.667888e-01 0.115 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.670021e-01 0.115 1 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.680206e-01 0.115 0 0
Membrane Trafficking R-HSA-199991 7.681702e-01 0.115 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.702247e-01 0.113 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.755526e-01 0.110 0 0
DNA replication initiation R-HSA-68952 7.755526e-01 0.110 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.755526e-01 0.110 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.755526e-01 0.110 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.755526e-01 0.110 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.755526e-01 0.110 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.755526e-01 0.110 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.755526e-01 0.110 0 0
Maturation of spike protein R-HSA-9683686 7.755526e-01 0.110 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.755526e-01 0.110 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.755526e-01 0.110 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.755526e-01 0.110 0 0
Peptide hormone biosynthesis R-HSA-209952 7.755526e-01 0.110 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.755526e-01 0.110 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.755526e-01 0.110 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.755526e-01 0.110 0 0
Formation of apoptosome R-HSA-111458 7.755526e-01 0.110 0 0
Extension of Telomeres R-HSA-180786 7.800143e-01 0.108 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.800632e-01 0.108 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.811587e-01 0.107 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.811587e-01 0.107 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.814642e-01 0.107 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.814642e-01 0.107 0 0
Activation of the pre-replicative complex R-HSA-68962 7.814642e-01 0.107 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.814642e-01 0.107 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.814642e-01 0.107 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.814642e-01 0.107 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.814642e-01 0.107 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.819805e-01 0.107 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.819805e-01 0.107 0 0
Nucleotide Excision Repair R-HSA-5696398 7.852708e-01 0.105 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.868607e-01 0.104 0 0
HIV Life Cycle R-HSA-162587 7.870477e-01 0.104 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.870790e-01 0.104 0 0
Signaling by FGFR2 R-HSA-5654738 7.902599e-01 0.102 0 0
Adipogenesis R-HSA-9843745 7.928696e-01 0.101 0 0
Platelet homeostasis R-HSA-418346 7.940112e-01 0.100 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.945294e-01 0.100 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.945294e-01 0.100 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.967202e-01 0.099 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.967202e-01 0.099 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.991466e-01 0.097 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.991466e-01 0.097 0 0
Lagging Strand Synthesis R-HSA-69186 7.991466e-01 0.097 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.991466e-01 0.097 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.991466e-01 0.097 1 1
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.991466e-01 0.097 0 0
ERK/MAPK targets R-HSA-198753 7.991466e-01 0.097 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.991466e-01 0.097 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.999315e-01 0.097 0 0
FGFR2b ligand binding and activation R-HSA-190377 7.999315e-01 0.097 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.999315e-01 0.097 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.999315e-01 0.097 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.999315e-01 0.097 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.999315e-01 0.097 0 0
Bicarbonate transporters R-HSA-425381 7.999315e-01 0.097 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.999315e-01 0.097 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.999315e-01 0.097 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.999315e-01 0.097 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.999315e-01 0.097 0 0
PECAM1 interactions R-HSA-210990 7.999315e-01 0.097 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.007214e-01 0.097 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.007214e-01 0.097 0 0
Regulation of insulin secretion R-HSA-422356 8.011951e-01 0.096 1 1
Viral Messenger RNA Synthesis R-HSA-168325 8.025852e-01 0.096 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.107114e-01 0.091 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.107114e-01 0.091 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.119842e-01 0.090 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.119842e-01 0.090 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.129641e-01 0.090 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.129641e-01 0.090 0 0
HIV Transcription Initiation R-HSA-167161 8.129641e-01 0.090 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.129641e-01 0.090 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.129641e-01 0.090 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.129641e-01 0.090 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.131764e-01 0.090 0 0
G1/S Transition R-HSA-69206 8.135263e-01 0.090 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.158102e-01 0.088 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.158102e-01 0.088 0 0
Attachment and Entry R-HSA-9694614 8.158102e-01 0.088 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.158102e-01 0.088 0 0
Neuronal System R-HSA-112316 8.163387e-01 0.088 1 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.175487e-01 0.087 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.180778e-01 0.087 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.216638e-01 0.085 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.216638e-01 0.085 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.216638e-01 0.085 0 0
NF-kB is activated and signals survival R-HSA-209560 8.216638e-01 0.085 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.216638e-01 0.085 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.216638e-01 0.085 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.216638e-01 0.085 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.216638e-01 0.085 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.216638e-01 0.085 0 0
Sodium/Calcium exchangers R-HSA-425561 8.216638e-01 0.085 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.216638e-01 0.085 0 0
Interleukin-1 signaling R-HSA-9020702 8.261612e-01 0.083 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.264834e-01 0.083 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.275352e-01 0.082 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.282566e-01 0.082 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.312251e-01 0.080 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.312251e-01 0.080 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.312251e-01 0.080 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.312251e-01 0.080 0 0
Signaling by KIT in disease R-HSA-9669938 8.312251e-01 0.080 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.312251e-01 0.080 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.362121e-01 0.078 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.372172e-01 0.077 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.372172e-01 0.077 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.372172e-01 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.410365e-01 0.075 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.410365e-01 0.075 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.410365e-01 0.075 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.410365e-01 0.075 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.410365e-01 0.075 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.410365e-01 0.075 0 0
MET activates RAS signaling R-HSA-8851805 8.410365e-01 0.075 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.410365e-01 0.075 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.410365e-01 0.075 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.410365e-01 0.075 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.410365e-01 0.075 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.410365e-01 0.075 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.410365e-01 0.075 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.410365e-01 0.075 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.413662e-01 0.075 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.454657e-01 0.073 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.454657e-01 0.073 0 0
Carnitine shuttle R-HSA-200425 8.454657e-01 0.073 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.454657e-01 0.073 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.454657e-01 0.073 0 0
Growth hormone receptor signaling R-HSA-982772 8.454657e-01 0.073 0 0
Surfactant metabolism R-HSA-5683826 8.468992e-01 0.072 0 0
UCH proteinases R-HSA-5689603 8.469164e-01 0.072 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.502376e-01 0.070 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.519458e-01 0.070 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.569911e-01 0.067 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.569911e-01 0.067 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.569911e-01 0.067 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.569911e-01 0.067 1 1
Formation of a pool of free 40S subunits R-HSA-72689 8.571342e-01 0.067 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.573408e-01 0.067 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.573408e-01 0.067 0 0
Signaling by FGFR1 R-HSA-5654736 8.573408e-01 0.067 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.583058e-01 0.066 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.583058e-01 0.066 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.583058e-01 0.066 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.583058e-01 0.066 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.583058e-01 0.066 0 0
Chylomicron remodeling R-HSA-8963901 8.583058e-01 0.066 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.583058e-01 0.066 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.583058e-01 0.066 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.583058e-01 0.066 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.583058e-01 0.066 0 0
Processing of SMDT1 R-HSA-8949664 8.583058e-01 0.066 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.583058e-01 0.066 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.583058e-01 0.066 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.583058e-01 0.066 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.583058e-01 0.066 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.583058e-01 0.066 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.583058e-01 0.066 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.586053e-01 0.066 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.586053e-01 0.066 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.586053e-01 0.066 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.586053e-01 0.066 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.586053e-01 0.066 0 0
Interleukin-12 family signaling R-HSA-447115 8.594403e-01 0.066 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.601757e-01 0.065 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.601757e-01 0.065 0 0
Oncogene Induced Senescence R-HSA-2559585 8.601757e-01 0.065 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.601757e-01 0.065 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.628045e-01 0.064 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.665104e-01 0.062 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.665104e-01 0.062 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.665104e-01 0.062 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.665104e-01 0.062 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.665104e-01 0.062 0 0
Selective autophagy R-HSA-9663891 8.666254e-01 0.062 0 0
Host Interactions of HIV factors R-HSA-162909 8.666917e-01 0.062 0 0
HIV Infection R-HSA-162906 8.689198e-01 0.061 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.705520e-01 0.060 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.705520e-01 0.060 0 0
Triglyceride catabolism R-HSA-163560 8.705520e-01 0.060 1 1
HSF1 activation R-HSA-3371511 8.705520e-01 0.060 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.705520e-01 0.060 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.707150e-01 0.060 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.707150e-01 0.060 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.707150e-01 0.060 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.736999e-01 0.059 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.736999e-01 0.059 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.736999e-01 0.059 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.736999e-01 0.059 0 0
The activation of arylsulfatases R-HSA-1663150 8.736999e-01 0.059 0 0
Hydrolysis of LPC R-HSA-1483115 8.736999e-01 0.059 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.736999e-01 0.059 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.736999e-01 0.059 0 0
Prolactin receptor signaling R-HSA-1170546 8.736999e-01 0.059 0 0
Physiological factors R-HSA-5578768 8.736999e-01 0.059 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.736999e-01 0.059 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.736999e-01 0.059 0 0
Malate-aspartate shuttle R-HSA-9856872 8.736999e-01 0.059 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.736999e-01 0.059 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.736999e-01 0.059 0 0
HDL assembly R-HSA-8963896 8.736999e-01 0.059 1 1
P2Y receptors R-HSA-417957 8.736999e-01 0.059 0 0
Dual incision in TC-NER R-HSA-6782135 8.743501e-01 0.058 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.743501e-01 0.058 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.754802e-01 0.058 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.773526e-01 0.057 1 0
Degradation of DVL R-HSA-4641258 8.802415e-01 0.055 0 0
NCAM1 interactions R-HSA-419037 8.802415e-01 0.055 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.818633e-01 0.055 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.818633e-01 0.055 0 0
Triglyceride metabolism R-HSA-8979227 8.821889e-01 0.054 1 0
Clathrin-mediated endocytosis R-HSA-8856828 8.822042e-01 0.054 0 0
Signaling by NOTCH R-HSA-157118 8.828217e-01 0.054 0 0
Metal ion SLC transporters R-HSA-425410 8.839237e-01 0.054 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.867947e-01 0.052 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.874223e-01 0.052 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.874223e-01 0.052 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.874223e-01 0.052 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.874223e-01 0.052 0 0
Signaling by Activin R-HSA-1502540 8.874223e-01 0.052 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.874223e-01 0.052 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.874223e-01 0.052 0 0
DNA Damage Reversal R-HSA-73942 8.874223e-01 0.052 0 0
PPARA activates gene expression R-HSA-1989781 8.914818e-01 0.050 0 0
Degradation of CDH1 R-HSA-9766229 8.918638e-01 0.050 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.921162e-01 0.050 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.921162e-01 0.050 0 0
Cristae formation R-HSA-8949613 8.921162e-01 0.050 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.921162e-01 0.050 0 0
Triglyceride biosynthesis R-HSA-75109 8.921162e-01 0.050 0 0
Synthesis of PE R-HSA-1483213 8.921162e-01 0.050 0 0
IRE1alpha activates chaperones R-HSA-381070 8.924265e-01 0.049 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.927820e-01 0.049 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.954787e-01 0.048 0 0
Aquaporin-mediated transport R-HSA-445717 8.966167e-01 0.047 1 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.966751e-01 0.047 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.977026e-01 0.047 0 0
Stabilization of p53 R-HSA-69541 8.977026e-01 0.047 0 0
Signaling by Insulin receptor R-HSA-74752 8.981820e-01 0.047 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.996546e-01 0.046 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.996546e-01 0.046 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.996546e-01 0.046 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.996546e-01 0.046 0 0
Activation of SMO R-HSA-5635838 8.996546e-01 0.046 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.996546e-01 0.046 0 0
Fructose catabolism R-HSA-70350 8.996546e-01 0.046 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.996546e-01 0.046 0 0
Negative regulation of FLT3 R-HSA-9706369 8.996546e-01 0.046 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.996546e-01 0.046 0 0
HCMV Late Events R-HSA-9610379 9.003857e-01 0.046 0 0
Inflammasomes R-HSA-622312 9.015366e-01 0.045 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.015366e-01 0.045 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.022260e-01 0.045 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.032388e-01 0.044 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.055437e-01 0.043 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.055437e-01 0.043 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.055437e-01 0.043 0 0
Diseases of Immune System R-HSA-5260271 9.055437e-01 0.043 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.055437e-01 0.043 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.101844e-01 0.041 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.101844e-01 0.041 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.101844e-01 0.041 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.105583e-01 0.041 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.105583e-01 0.041 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.105583e-01 0.041 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.105583e-01 0.041 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.105583e-01 0.041 0 0
Coenzyme A biosynthesis R-HSA-196783 9.105583e-01 0.041 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.105583e-01 0.041 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.105583e-01 0.041 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.128367e-01 0.040 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.128923e-01 0.040 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.128923e-01 0.040 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.133804e-01 0.039 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.148347e-01 0.039 0 0
RSV-host interactions R-HSA-9833110 9.150433e-01 0.039 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.190453e-01 0.037 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.190453e-01 0.037 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.196137e-01 0.036 0 0
Translation of Structural Proteins R-HSA-9683701 9.196137e-01 0.036 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.202778e-01 0.036 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.202778e-01 0.036 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.202778e-01 0.036 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.202778e-01 0.036 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.202778e-01 0.036 0 0
Glycogen storage diseases R-HSA-3229121 9.202778e-01 0.036 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.202778e-01 0.036 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.202778e-01 0.036 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.202778e-01 0.036 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.202778e-01 0.036 0 0
Catecholamine biosynthesis R-HSA-209905 9.202778e-01 0.036 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.211534e-01 0.036 0 0
Potassium Channels R-HSA-1296071 9.232050e-01 0.035 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.242106e-01 0.034 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.248060e-01 0.034 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.248060e-01 0.034 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.253852e-01 0.034 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.253852e-01 0.034 0 0
Developmental Cell Lineages R-HSA-9734767 9.267239e-01 0.033 0 0
Peptide chain elongation R-HSA-156902 9.277048e-01 0.033 0 0
Transmission across Chemical Synapses R-HSA-112315 9.286342e-01 0.032 1 0
L1CAM interactions R-HSA-373760 9.288132e-01 0.032 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.289416e-01 0.032 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.289416e-01 0.032 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.289416e-01 0.032 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.289416e-01 0.032 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.289416e-01 0.032 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.289416e-01 0.032 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.289416e-01 0.032 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.289416e-01 0.032 0 0
Nephron development R-HSA-9831926 9.289416e-01 0.032 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.301951e-01 0.031 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.310788e-01 0.031 0 0
Signaling by FGFR R-HSA-190236 9.316172e-01 0.031 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.320420e-01 0.031 0 0
HS-GAG degradation R-HSA-2024096 9.320420e-01 0.031 0 0
Phospholipid metabolism R-HSA-1483257 9.324512e-01 0.030 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.352326e-01 0.029 0 0
Downstream TCR signaling R-HSA-202424 9.360634e-01 0.029 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.366644e-01 0.028 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.366644e-01 0.028 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.366644e-01 0.028 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.366644e-01 0.028 0 0
Diseases of hemostasis R-HSA-9671793 9.366644e-01 0.028 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.371542e-01 0.028 0 0
Amine ligand-binding receptors R-HSA-375280 9.371542e-01 0.028 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.374599e-01 0.028 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.381338e-01 0.028 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.399142e-01 0.027 0 0
Regulation of CDH1 Function R-HSA-9764561 9.399379e-01 0.027 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.399550e-01 0.027 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.400972e-01 0.027 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.435482e-01 0.025 0 0
Glycogen synthesis R-HSA-3322077 9.435482e-01 0.025 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.435482e-01 0.025 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.435482e-01 0.025 0 0
Pregnenolone biosynthesis R-HSA-196108 9.435482e-01 0.025 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.437046e-01 0.025 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.437046e-01 0.025 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.437046e-01 0.025 1 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.437046e-01 0.025 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.437046e-01 0.025 0 0
HCMV Infection R-HSA-9609646 9.441417e-01 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.443298e-01 0.025 0 0
Gastrulation R-HSA-9758941 9.449891e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.468052e-01 0.024 0 0
Parasite infection R-HSA-9664407 9.468429e-01 0.024 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.468429e-01 0.024 0 0
Leishmania phagocytosis R-HSA-9664417 9.468429e-01 0.024 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.472938e-01 0.024 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.484262e-01 0.023 0 0
Dual Incision in GG-NER R-HSA-5696400 9.487958e-01 0.023 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.487958e-01 0.023 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.487958e-01 0.023 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.487958e-01 0.023 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.487958e-01 0.023 0 0
Signal amplification R-HSA-392518 9.487958e-01 0.023 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.496841e-01 0.022 0 0
G-protein activation R-HSA-202040 9.496841e-01 0.022 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.496841e-01 0.022 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.496841e-01 0.022 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.496841e-01 0.022 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.496841e-01 0.022 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.496841e-01 0.022 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.496841e-01 0.022 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.496841e-01 0.022 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.496841e-01 0.022 0 0
Basigin interactions R-HSA-210991 9.496841e-01 0.022 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.510959e-01 0.022 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.510959e-01 0.022 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.522143e-01 0.021 0 0
GABA receptor activation R-HSA-977443 9.522443e-01 0.021 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.534457e-01 0.021 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.534457e-01 0.021 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.534457e-01 0.021 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.534457e-01 0.021 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.545763e-01 0.020 0 0
Intraflagellar transport R-HSA-5620924 9.550618e-01 0.020 0 0
GPER1 signaling R-HSA-9634597 9.550618e-01 0.020 1 1
Gluconeogenesis R-HSA-70263 9.550618e-01 0.020 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.551535e-01 0.020 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.551535e-01 0.020 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.551535e-01 0.020 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.562450e-01 0.019 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.562450e-01 0.019 0 0
Cellular responses to stress R-HSA-2262752 9.571497e-01 0.019 0 0
HS-GAG biosynthesis R-HSA-2022928 9.576901e-01 0.019 0 0
Gap junction trafficking and regulation R-HSA-157858 9.587250e-01 0.018 0 0
DNA Damage Bypass R-HSA-73893 9.587250e-01 0.018 0 0
Eukaryotic Translation Termination R-HSA-72764 9.589865e-01 0.018 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.591114e-01 0.018 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.594846e-01 0.018 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.595153e-01 0.018 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.600286e-01 0.018 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.600286e-01 0.018 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.600286e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.600286e-01 0.018 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.600286e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.600286e-01 0.018 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.609845e-01 0.017 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.615622e-01 0.017 0 0
Voltage gated Potassium channels R-HSA-1296072 9.615622e-01 0.017 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.615622e-01 0.017 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.615622e-01 0.017 0 0
Cellular responses to stimuli R-HSA-8953897 9.619537e-01 0.017 1 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.626765e-01 0.017 0 0
Synthesis of DNA R-HSA-69239 9.626765e-01 0.017 0 0
Mitochondrial biogenesis R-HSA-1592230 9.640584e-01 0.016 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.643740e-01 0.016 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.643740e-01 0.016 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.643740e-01 0.016 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.643740e-01 0.016 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.643740e-01 0.016 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.643740e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.643740e-01 0.016 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.643740e-01 0.016 0 0
Ion transport by P-type ATPases R-HSA-936837 9.650544e-01 0.015 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.650544e-01 0.015 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.652262e-01 0.015 0 0
The phototransduction cascade R-HSA-2514856 9.652262e-01 0.015 0 0
Orc1 removal from chromatin R-HSA-68949 9.681024e-01 0.014 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.682473e-01 0.014 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.682473e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.682473e-01 0.014 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.682473e-01 0.014 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.682473e-01 0.014 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.682473e-01 0.014 1 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.683103e-01 0.014 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.683662e-01 0.014 0 0
PCP/CE pathway R-HSA-4086400 9.687156e-01 0.014 0 0
Integrin cell surface interactions R-HSA-216083 9.687156e-01 0.014 0 0
SARS-CoV Infections R-HSA-9679506 9.705600e-01 0.013 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.707528e-01 0.013 0 0
Neutrophil degranulation R-HSA-6798695 9.710442e-01 0.013 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.712410e-01 0.013 0 0
Attenuation phase R-HSA-3371568 9.712410e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.716996e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.716996e-01 0.012 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.716996e-01 0.012 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.716996e-01 0.012 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.716996e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.716996e-01 0.012 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.716996e-01 0.012 0 0
Selenocysteine synthesis R-HSA-2408557 9.724147e-01 0.012 0 0
Signaling by MET R-HSA-6806834 9.730545e-01 0.012 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.739093e-01 0.011 0 0
Maturation of spike protein R-HSA-9694548 9.739093e-01 0.011 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.739093e-01 0.011 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.739093e-01 0.011 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.742140e-01 0.011 0 0
MET activates PTK2 signaling R-HSA-8874081 9.747768e-01 0.011 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.747768e-01 0.011 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.747768e-01 0.011 0 0
Metalloprotease DUBs R-HSA-5689901 9.747768e-01 0.011 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.747768e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.747768e-01 0.011 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.747768e-01 0.011 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.750079e-01 0.011 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.754405e-01 0.011 0 0
Viral mRNA Translation R-HSA-192823 9.759048e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.760788e-01 0.011 0 0
Intra-Golgi traffic R-HSA-6811438 9.763376e-01 0.010 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.774929e-01 0.010 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.775074e-01 0.010 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.775195e-01 0.010 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.775195e-01 0.010 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.775195e-01 0.010 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.775195e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.775195e-01 0.010 0 0
Insulin processing R-HSA-264876 9.775195e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.775195e-01 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.784039e-01 0.009 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.785251e-01 0.009 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.785464e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.792814e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.794081e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.799642e-01 0.009 0 0
Retinoid metabolism and transport R-HSA-975634 9.800960e-01 0.009 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.805549e-01 0.009 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.805549e-01 0.009 0 0
Defensins R-HSA-1461973 9.805549e-01 0.009 0 0
Influenza Infection R-HSA-168255 9.809066e-01 0.008 0 0
Hemostasis R-HSA-109582 9.812628e-01 0.008 1 0
Platelet degranulation R-HSA-114608 9.818656e-01 0.008 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.820815e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.821431e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.821431e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.821431e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.821431e-01 0.008 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.822531e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.827596e-01 0.008 0 0
Regulation of beta-cell development R-HSA-186712 9.827596e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.827596e-01 0.008 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.840389e-01 0.007 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.840389e-01 0.007 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.840389e-01 0.007 1 1
Somitogenesis R-HSA-9824272 9.840389e-01 0.007 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.840852e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.840852e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.840852e-01 0.007 0 0
Mucopolysaccharidoses R-HSA-2206281 9.840852e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.842330e-01 0.007 0 0
Leishmania infection R-HSA-9658195 9.855266e-01 0.006 1 0
Parasitic Infection Pathways R-HSA-9824443 9.855266e-01 0.006 1 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.855853e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.856264e-01 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.856908e-01 0.006 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.858162e-01 0.006 0 0
Budding and maturation of HIV virion R-HSA-162588 9.858162e-01 0.006 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.858162e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.858162e-01 0.006 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.858162e-01 0.006 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.858162e-01 0.006 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.858162e-01 0.006 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.869129e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.869129e-01 0.006 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.873589e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.878927e-01 0.005 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.882963e-01 0.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.885057e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.887340e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.887340e-01 0.005 0 0
Neddylation R-HSA-8951664 9.887474e-01 0.005 0 0
Interleukin-10 signaling R-HSA-6783783 9.888687e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.890304e-01 0.005 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.897694e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.899596e-01 0.004 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.899596e-01 0.004 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.899596e-01 0.004 0 0
Cellular response to hypoxia R-HSA-1234174 9.899621e-01 0.004 0 0
Cellular response to starvation R-HSA-9711097 9.906879e-01 0.004 0 0
eNOS activation R-HSA-203615 9.910519e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.910519e-01 0.004 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.910519e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.910519e-01 0.004 0 0
Signaling by NOTCH2 R-HSA-1980145 9.910519e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.910519e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.910519e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.910519e-01 0.004 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.910519e-01 0.004 0 0
Mitophagy R-HSA-5205647 9.910519e-01 0.004 0 0
Interferon gamma signaling R-HSA-877300 9.912573e-01 0.004 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.913660e-01 0.004 0 0
Metabolism of steroid hormones R-HSA-196071 9.916387e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.916387e-01 0.004 0 0
Regulation of Apoptosis R-HSA-169911 9.920254e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.920254e-01 0.003 0 0
PERK regulates gene expression R-HSA-381042 9.920254e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.920254e-01 0.003 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.923721e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.923721e-01 0.003 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.928202e-01 0.003 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.928930e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.928930e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.936663e-01 0.003 0 0
Degradation of AXIN R-HSA-4641257 9.936663e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.936663e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.936663e-01 0.003 0 0
rRNA processing R-HSA-72312 9.938433e-01 0.003 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.939305e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.942179e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.942179e-01 0.003 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.943555e-01 0.002 0 0
Purine salvage R-HSA-74217 9.943555e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.943555e-01 0.002 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.943555e-01 0.002 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.947307e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.948474e-01 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.949698e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.949698e-01 0.002 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.949698e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.952178e-01 0.002 0 0
Vesicle-mediated transport R-HSA-5653656 9.952199e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.952422e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.954275e-01 0.002 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.955172e-01 0.002 0 0
Signaling by NOTCH4 R-HSA-9013694 9.956273e-01 0.002 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.960051e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.960181e-01 0.002 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.960996e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.962405e-01 0.002 1 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.963919e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.964785e-01 0.002 0 0
Immune System R-HSA-168256 9.966060e-01 0.001 1 0
Formation of paraxial mesoderm R-HSA-9793380 9.968211e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.968274e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.968274e-01 0.001 0 0
Ribosome-associated quality control R-HSA-9948299 9.968354e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.969974e-01 0.001 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.971077e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.971309e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.971728e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.974109e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.974805e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.974805e-01 0.001 0 0
Gap junction trafficking R-HSA-190828 9.974805e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.974805e-01 0.001 0 0
PKR-mediated signaling R-HSA-9833482 9.975153e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.979993e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.980993e-01 0.001 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.981031e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.982859e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984112e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.984544e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.985842e-01 0.001 0 0
Interferon Signaling R-HSA-913531 9.987092e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.988405e-01 0.001 1 1
Chaperonin-mediated protein folding R-HSA-390466 9.988445e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.988679e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.988758e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.988758e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.989798e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.990476e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.990509e-01 0.000 0 0
Protein localization R-HSA-9609507 9.990563e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.990807e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.991356e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.991441e-01 0.000 1 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991718e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992027e-01 0.000 0 0
Cellular response to chemical stress R-HSA-9711123 9.992830e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.992912e-01 0.000 0 0
Signaling by NOTCH3 R-HSA-9012852 9.992912e-01 0.000 0 0
tRNA processing R-HSA-72306 9.993398e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.993473e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.993536e-01 0.000 0 0
Protein folding R-HSA-391251 9.993544e-01 0.000 0 0
Digestion R-HSA-8935690 9.993684e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.994179e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.994551e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.994551e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.994551e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.994690e-01 0.000 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.994887e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.994887e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.995875e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.996019e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996044e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996453e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996453e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996453e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.997018e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997056e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997102e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997184e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.997334e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997491e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.997764e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998101e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998377e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.998745e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998745e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.998758e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998996e-01 0.000 1 0
Formation of the cornified envelope R-HSA-6809371 9.998997e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999098e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999109e-01 0.000 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.999295e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999295e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999390e-01 0.000 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999472e-01 0.000 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.999472e-01 0.000 1 0
Interferon alpha/beta signaling R-HSA-909733 9.999560e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999648e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999755e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999786e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999860e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999889e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999902e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999930e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999955e-01 0.000 1 0
Mitochondrial translation elongation R-HSA-5389840 9.999956e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999959e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999960e-01 0.000 1 0
Mitochondrial translation initiation R-HSA-5368286 9.999965e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999971e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999974e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999977e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999980e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999985e-01 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999988e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999990e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999991e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999992e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 1 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 4.772682e-11 10.321 0 0
Chromatin modifying enzymes R-HSA-3247509 2.207826e-10 9.656 0 0
Chromatin organization R-HSA-4839726 7.963804e-10 9.099 0 0
HSF1-dependent transactivation R-HSA-3371571 1.006504e-09 8.997 0 0
HSF1 activation R-HSA-3371511 7.031547e-09 8.153 0 0
Cellular response to heat stress R-HSA-3371556 1.249040e-08 7.903 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.295336e-08 7.888 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.122656e-08 7.505 0 0
Cell Cycle R-HSA-1640170 3.880807e-08 7.411 0 0
HDACs deacetylate histones R-HSA-3214815 6.392079e-08 7.194 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.668945e-08 7.176 0 0
Cell Cycle Checkpoints R-HSA-69620 7.777000e-08 7.109 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.768556e-07 6.752 0 0
Apoptotic execution phase R-HSA-75153 2.982349e-07 6.525 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.728441e-07 6.428 0 0
Cellular Senescence R-HSA-2559583 4.043649e-07 6.393 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.606297e-07 6.337 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.987264e-07 6.156 0 0
G2/M Checkpoints R-HSA-69481 9.349941e-07 6.029 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.673099e-06 5.776 0 0
Cell Cycle, Mitotic R-HSA-69278 2.588800e-06 5.587 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.609679e-06 5.583 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.121238e-06 5.506 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.013243e-06 5.521 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.077377e-06 5.512 0 0
Nucleosome assembly R-HSA-774815 3.414801e-06 5.467 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.414801e-06 5.467 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.436309e-06 5.353 0 0
DNA Double Strand Break Response R-HSA-5693606 4.403147e-06 5.356 0 0
Diseases of programmed cell death R-HSA-9645723 3.986603e-06 5.399 0 0
Regulation of TP53 Activity R-HSA-5633007 4.319603e-06 5.365 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.825288e-06 5.316 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.865909e-06 5.313 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.825288e-06 5.316 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.536145e-06 5.185 0 0
Meiotic synapsis R-HSA-1221632 7.000402e-06 5.155 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.661548e-06 5.116 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.986183e-06 5.001 0 0
Signal Transduction R-HSA-162582 1.006573e-05 4.997 1 0
Packaging Of Telomere Ends R-HSA-171306 1.041394e-05 4.982 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.180284e-05 4.928 0 0
Apoptosis R-HSA-109581 1.269260e-05 4.896 0 0
HATs acetylate histones R-HSA-3214847 1.338966e-05 4.873 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.589042e-05 4.799 0 0
Programmed Cell Death R-HSA-5357801 2.001103e-05 4.699 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.539270e-05 4.595 0 0
Defective pyroptosis R-HSA-9710421 2.700039e-05 4.569 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.415379e-05 4.467 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.484524e-05 4.458 0 0
RNA Polymerase I Transcription R-HSA-73864 3.647035e-05 4.438 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.672329e-05 4.435 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.493247e-05 4.347 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.742387e-05 4.324 0 0
Death Receptor Signaling R-HSA-73887 5.342893e-05 4.272 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.122574e-05 4.213 0 0
Cleavage of the damaged purine R-HSA-110331 6.122574e-05 4.213 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.912599e-05 4.160 0 0
Mitotic Prophase R-HSA-68875 6.858927e-05 4.164 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.131118e-05 4.147 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.168931e-05 4.145 0 0
M Phase R-HSA-68886 7.508063e-05 4.124 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.547910e-05 4.122 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.909856e-05 4.102 0 0
Depurination R-HSA-73927 7.823311e-05 4.107 0 0
DNA methylation R-HSA-5334118 8.044722e-05 4.094 0 0
Cell-Cell communication R-HSA-1500931 8.561523e-05 4.067 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.043860e-04 3.981 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.249839e-04 3.903 0 0
NRAGE signals death through JNK R-HSA-193648 1.336794e-04 3.874 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.514633e-04 3.820 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.626877e-04 3.789 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.715269e-04 3.766 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.860195e-04 3.730 0 0
mRNA 3'-end processing R-HSA-72187 1.860195e-04 3.730 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.866702e-04 3.729 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.956990e-04 3.708 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.124113e-04 3.673 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.124113e-04 3.673 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.132387e-04 3.671 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.321389e-04 3.634 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.519425e-04 3.599 0 0
Homology Directed Repair R-HSA-5693538 2.771190e-04 3.557 0 0
Cell junction organization R-HSA-446728 2.697275e-04 3.569 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.696102e-04 3.569 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.929631e-04 3.533 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.940970e-04 3.532 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.022463e-04 3.520 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.259182e-04 3.487 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.712842e-04 3.430 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.846410e-04 3.415 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.412803e-04 3.355 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.005033e-04 3.301 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.005033e-04 3.301 0 0
FLT3 Signaling R-HSA-9607240 5.005033e-04 3.301 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.980005e-04 3.223 0 0
Regulation of PTEN localization R-HSA-8948747 6.167901e-04 3.210 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.423775e-04 3.192 0 0
Meiosis R-HSA-1500620 7.055608e-04 3.151 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.387850e-04 3.131 0 0
Depyrimidination R-HSA-73928 7.387850e-04 3.131 0 0
NGF-stimulated transcription R-HSA-9031628 7.588749e-04 3.120 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.118855e-04 3.091 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.992255e-04 3.097 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.289932e-04 3.081 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.633782e-04 3.064 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.693723e-04 3.061 0 0
Striated Muscle Contraction R-HSA-390522 9.651279e-04 3.015 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.004239e-03 2.998 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.011675e-03 2.995 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.011675e-03 2.995 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.724236e-04 3.012 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.034088e-03 2.985 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.040506e-03 2.983 0 0
Signaling by WNT R-HSA-195721 1.100904e-03 2.958 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.249414e-03 2.903 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.353904e-03 2.868 0 0
Meiotic recombination R-HSA-912446 1.262476e-03 2.899 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.271651e-03 2.896 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.500823e-03 2.824 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.555930e-03 2.808 0 0
G alpha (12/13) signalling events R-HSA-416482 1.571883e-03 2.804 0 0
FLT3 signaling in disease R-HSA-9682385 1.755376e-03 2.756 0 0
mRNA Splicing R-HSA-72172 1.763082e-03 2.754 0 0
Muscle contraction R-HSA-397014 1.810394e-03 2.742 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.002504e-03 2.698 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.021366e-03 2.694 0 0
Gene expression (Transcription) R-HSA-74160 2.115520e-03 2.675 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.301549e-03 2.638 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.312405e-03 2.636 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.312405e-03 2.636 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.468417e-03 2.608 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.672288e-03 2.573 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.450963e-03 2.462 0 0
Chromosome Maintenance R-HSA-73886 3.433830e-03 2.464 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.434546e-03 2.464 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.317064e-03 2.479 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.367527e-03 2.473 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.582549e-03 2.446 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.830791e-03 2.417 0 0
Deubiquitination R-HSA-5688426 3.990562e-03 2.399 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.155730e-03 2.381 1 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.426362e-03 2.354 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.893335e-03 2.310 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.893335e-03 2.310 0 0
Negative regulation of FLT3 R-HSA-9706369 4.711263e-03 2.327 0 0
Adherens junctions interactions R-HSA-418990 4.709476e-03 2.327 0 0
Cellular responses to stress R-HSA-2262752 4.450450e-03 2.352 0 0
Ub-specific processing proteases R-HSA-5689880 4.958343e-03 2.305 0 0
Amyloid fiber formation R-HSA-977225 5.055665e-03 2.296 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.077483e-03 2.294 0 0
Protein ubiquitination R-HSA-8852135 5.604489e-03 2.251 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.607150e-03 2.251 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.607150e-03 2.251 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.607150e-03 2.251 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.607150e-03 2.251 0 0
ESR-mediated signaling R-HSA-8939211 5.745391e-03 2.241 0 0
Gene Silencing by RNA R-HSA-211000 5.889044e-03 2.230 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.909750e-03 2.228 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.967843e-03 2.224 0 0
Metalloprotease DUBs R-HSA-5689901 5.968187e-03 2.224 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.088960e-03 2.215 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.253408e-03 2.204 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.209947e-03 2.142 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.216303e-03 2.142 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.099289e-03 2.092 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.099289e-03 2.092 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.099289e-03 2.092 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.099289e-03 2.092 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.277944e-03 2.082 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.507178e-03 2.070 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.680383e-03 2.115 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.277944e-03 2.082 0 0
RNA Polymerase II Transcription R-HSA-73857 8.026149e-03 2.095 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.003614e-03 2.097 0 0
Cell-cell junction organization R-HSA-421270 8.172079e-03 2.088 0 0
RMTs methylate histone arginines R-HSA-3214858 7.680383e-03 2.115 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.158325e-03 2.088 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.564104e-03 2.067 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.564104e-03 2.067 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 9.321995e-03 2.030 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 9.321995e-03 2.030 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.321995e-03 2.030 0 0
Maturation of protein E R-HSA-9683683 9.321995e-03 2.030 0 0
Maturation of protein E R-HSA-9694493 9.321995e-03 2.030 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.935447e-03 2.003 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.935447e-03 2.003 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.935447e-03 2.003 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.976378e-03 2.001 0 0
DNA Replication R-HSA-69306 1.013030e-02 1.994 0 0
Late endosomal microautophagy R-HSA-9615710 1.030053e-02 1.987 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.073451e-02 1.969 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.073451e-02 1.969 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.073451e-02 1.969 0 0
Regulation of signaling by CBL R-HSA-912631 1.202712e-02 1.920 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.238267e-02 1.907 0 0
Oncogene Induced Senescence R-HSA-2559585 1.163123e-02 1.934 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.217117e-02 1.915 0 0
Josephin domain DUBs R-HSA-5689877 1.098987e-02 1.959 0 0
Neurodegenerative Diseases R-HSA-8863678 1.238267e-02 1.907 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.238267e-02 1.907 0 0
Axon guidance R-HSA-422475 1.176745e-02 1.929 1 0
ISG15 antiviral mechanism R-HSA-1169408 1.195049e-02 1.923 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.252467e-02 1.902 1 0
Cellular responses to stimuli R-HSA-8953897 1.266332e-02 1.897 1 0
Nervous system development R-HSA-9675108 1.271910e-02 1.896 1 0
Regulation of TP53 Degradation R-HSA-6804757 1.348548e-02 1.870 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.366704e-02 1.864 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.366704e-02 1.864 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.366704e-02 1.864 0 0
p75NTR signals via NF-kB R-HSA-193639 1.366704e-02 1.864 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.381094e-02 1.860 0 0
EGFR downregulation R-HSA-182971 1.428383e-02 1.845 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.428383e-02 1.845 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.433773e-02 1.844 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.468326e-02 1.833 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.468326e-02 1.833 0 0
Signaling by EGFR R-HSA-177929 1.503997e-02 1.823 0 0
TNF signaling R-HSA-75893 1.503997e-02 1.823 0 0
Telomere Maintenance R-HSA-157579 1.584979e-02 1.800 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.630664e-02 1.788 1 1
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.912729e-02 1.718 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.779583e-02 1.750 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.779583e-02 1.750 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.817656e-02 1.740 0 0
NF-kB is activated and signals survival R-HSA-209560 1.912729e-02 1.718 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.817656e-02 1.740 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.817656e-02 1.740 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.749116e-02 1.757 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.683195e-02 1.774 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.912729e-02 1.718 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.844041e-02 1.734 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.855626e-02 1.732 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.930297e-02 1.714 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.030221e-02 1.692 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.038063e-02 1.691 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.112264e-02 1.675 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.112264e-02 1.675 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.130969e-02 1.671 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.174993e-02 1.663 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.196299e-02 1.658 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.224223e-02 1.653 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.353477e-02 1.628 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.359658e-02 1.627 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.359658e-02 1.627 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.359658e-02 1.627 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.437371e-02 1.613 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.437371e-02 1.613 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.437371e-02 1.613 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.468788e-02 1.608 1 1
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.527792e-02 1.597 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.548878e-02 1.594 0 0
Base Excision Repair R-HSA-73884 2.630365e-02 1.580 0 0
Formation of annular gap junctions R-HSA-196025 2.638999e-02 1.579 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.638999e-02 1.579 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.638999e-02 1.579 0 0
Signaling by NOTCH1 R-HSA-1980143 2.640779e-02 1.578 0 0
Co-inhibition by PD-1 R-HSA-389948 2.688268e-02 1.571 0 0
Reproduction R-HSA-1474165 2.689347e-02 1.570 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.093472e-02 1.510 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.775421e-02 1.557 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.997742e-02 1.523 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.758252e-02 1.559 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.046508e-02 1.516 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.296150e-02 1.482 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.891630e-02 1.539 0 0
Mitotic Anaphase R-HSA-68882 2.748743e-02 1.561 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.954870e-02 1.529 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.211333e-02 1.493 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.775421e-02 1.557 0 0
Activation of BH3-only proteins R-HSA-114452 3.194465e-02 1.496 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.043568e-02 1.517 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.004768e-02 1.522 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.282394e-02 1.484 0 0
Interleukin-37 signaling R-HSA-9008059 3.194465e-02 1.496 0 0
MTOR signalling R-HSA-165159 3.316659e-02 1.479 0 0
Signaling by NTRKs R-HSA-166520 3.433188e-02 1.464 0 0
Gap junction degradation R-HSA-190873 3.460259e-02 1.461 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.460259e-02 1.461 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.460259e-02 1.461 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.483554e-02 1.458 0 0
Regulation of CDH1 Function R-HSA-9764561 3.543008e-02 1.451 0 0
HIV Life Cycle R-HSA-162587 3.603713e-02 1.443 0 0
Translesion Synthesis by POLH R-HSA-110320 3.679692e-02 1.434 0 0
Rap1 signalling R-HSA-392517 3.679692e-02 1.434 1 1
Regulation of T cell activation by CD28 family R-HSA-388841 3.713936e-02 1.430 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.721408e-02 1.429 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.743428e-02 1.427 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.747514e-02 1.426 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.749071e-02 1.426 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.892796e-02 1.410 0 0
Netrin-1 signaling R-HSA-373752 4.130961e-02 1.384 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.413809e-02 1.355 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.530429e-02 1.344 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.530429e-02 1.344 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.332564e-02 1.363 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.612222e-02 1.336 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.704418e-02 1.327 0 0
Regulated Necrosis R-HSA-5218859 4.857735e-02 1.314 0 0
Translesion synthesis by REV1 R-HSA-110312 4.530429e-02 1.344 0 0
Nuclear RNA decay R-HSA-9930044 4.704418e-02 1.327 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.182656e-02 1.379 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.704418e-02 1.327 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.530429e-02 1.344 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.819955e-02 1.317 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.804285e-02 1.318 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.217092e-02 1.283 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.245719e-02 1.372 0 0
Negative regulation of MET activity R-HSA-6807004 4.332564e-02 1.363 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.465177e-02 1.350 0 0
Signaling by VEGF R-HSA-194138 5.063188e-02 1.296 1 0
Glycogen metabolism R-HSA-8982491 5.217092e-02 1.283 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.885502e-02 1.311 0 0
Smooth Muscle Contraction R-HSA-445355 4.888386e-02 1.311 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.682336e-02 1.330 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.145688e-02 1.289 0 0
Generic Transcription Pathway R-HSA-212436 4.250470e-02 1.372 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.217141e-02 1.375 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.053632e-02 1.296 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.680920e-02 1.330 0 0
Pexophagy R-HSA-9664873 4.413809e-02 1.355 0 0
Interleukin-12 signaling R-HSA-9020591 4.983213e-02 1.302 0 0
DNA Repair R-HSA-73894 5.221784e-02 1.282 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.265897e-02 1.279 0 0
Autophagy R-HSA-9612973 5.353155e-02 1.271 0 0
Translesion synthesis by POLI R-HSA-5656121 5.408821e-02 1.267 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.408821e-02 1.267 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.454673e-02 1.263 0 0
Macroautophagy R-HSA-1632852 5.533224e-02 1.257 0 0
Signaling by NOTCH R-HSA-157118 5.643360e-02 1.248 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.712857e-02 1.243 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.791922e-02 1.237 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.843915e-02 1.233 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.843915e-02 1.233 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.853968e-02 1.233 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.933388e-02 1.227 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.933388e-02 1.227 0 0
Nuclear import of Rev protein R-HSA-180746 5.933388e-02 1.227 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.974855e-02 1.224 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.974855e-02 1.224 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.051186e-02 1.218 0 0
Signaling by PTK6 R-HSA-8848021 6.051186e-02 1.218 0 0
Diseases of Cellular Senescence R-HSA-9630747 6.244675e-02 1.204 0 0
Diseases of cellular response to stress R-HSA-9675132 6.244675e-02 1.204 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.407287e-02 1.193 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.407287e-02 1.193 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.181580e-02 1.087 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.181580e-02 1.087 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.181580e-02 1.087 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 8.181580e-02 1.087 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.181580e-02 1.087 0 0
Signaling by AXIN mutants R-HSA-4839735 6.716627e-02 1.173 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.716627e-02 1.173 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.060467e-02 1.094 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.060467e-02 1.094 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.060467e-02 1.094 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.060467e-02 1.094 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.060467e-02 1.094 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.060467e-02 1.094 0 0
Translesion synthesis by POLK R-HSA-5655862 6.378948e-02 1.195 0 0
FGFR2 alternative splicing R-HSA-6803529 6.703908e-02 1.174 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.739668e-02 1.171 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.560582e-02 1.121 0 0
RET signaling R-HSA-8853659 7.347300e-02 1.134 1 1
Signaling by RAF1 mutants R-HSA-9656223 6.406012e-02 1.193 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.406012e-02 1.193 1 1
Regulation of RAS by GAPs R-HSA-5658442 7.358171e-02 1.133 0 0
Metabolism of non-coding RNA R-HSA-194441 8.174259e-02 1.088 0 0
snRNP Assembly R-HSA-191859 8.174259e-02 1.088 0 0
Hedgehog 'off' state R-HSA-5610787 6.271106e-02 1.203 1 1
Regulation of FZD by ubiquitination R-HSA-4641263 7.440233e-02 1.128 0 0
MAP2K and MAPK activation R-HSA-5674135 6.406012e-02 1.193 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.493732e-02 1.188 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.463661e-02 1.127 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.623137e-02 1.179 0 0
Separation of Sister Chromatids R-HSA-2467813 7.943529e-02 1.100 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.617008e-02 1.179 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.059813e-02 1.151 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.176766e-02 1.144 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.378948e-02 1.195 0 0
Rab regulation of trafficking R-HSA-9007101 7.773242e-02 1.109 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.739668e-02 1.171 0 0
Hedgehog 'on' state R-HSA-5632684 6.176300e-02 1.209 0 0
Metabolism of RNA R-HSA-8953854 7.492513e-02 1.125 0 0
Membrane Trafficking R-HSA-199991 7.011681e-02 1.154 0 0
Signaling by FGFR2 R-HSA-5654738 6.718428e-02 1.173 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.956926e-02 1.158 0 0
G1/S Transition R-HSA-69206 8.056761e-02 1.094 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.703908e-02 1.174 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.753619e-02 1.110 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.181580e-02 1.087 0 0
Glycogen storage diseases R-HSA-3229121 7.440233e-02 1.128 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.032381e-02 1.153 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.060467e-02 1.094 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.060467e-02 1.094 0 0
Signaling by Hippo R-HSA-2028269 7.440233e-02 1.128 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.060467e-02 1.094 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.060467e-02 1.094 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.124431e-02 1.090 0 0
Stimuli-sensing channels R-HSA-2672351 6.623137e-02 1.179 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.437524e-02 1.074 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.437524e-02 1.074 0 0
Budding and maturation of HIV virion R-HSA-162588 8.437524e-02 1.074 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.437524e-02 1.074 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.487570e-02 1.071 0 0
HCMV Late Events R-HSA-9610379 8.532328e-02 1.069 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.591229e-02 1.066 0 0
Polo-like kinase mediated events R-HSA-156711 8.591229e-02 1.066 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.591229e-02 1.066 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.624067e-02 1.064 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.632422e-02 1.064 0 0
Orc1 removal from chromatin R-HSA-68949 8.709422e-02 1.060 0 0
Neurexins and neuroligins R-HSA-6794361 8.709422e-02 1.060 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.709422e-02 1.060 0 0
Signaling by ERBB2 R-HSA-1227986 8.829548e-02 1.054 0 0
Kinesins R-HSA-983189 8.829548e-02 1.054 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.829548e-02 1.054 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.829548e-02 1.054 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.829548e-02 1.054 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.829548e-02 1.054 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.829548e-02 1.054 0 0
UCH proteinases R-HSA-5689603 8.865217e-02 1.052 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.948345e-02 1.048 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.948345e-02 1.048 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.147334e-02 1.039 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.147334e-02 1.039 0 0
MET activates PTPN11 R-HSA-8865999 9.147334e-02 1.039 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.370102e-02 1.028 0 0
Mitotic Prometaphase R-HSA-68877 9.509917e-02 1.022 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.523423e-02 1.021 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.526216e-02 1.021 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.526216e-02 1.021 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 9.593490e-02 1.018 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 9.593490e-02 1.018 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.593490e-02 1.018 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 9.593490e-02 1.018 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.627169e-02 1.017 0 0
HDMs demethylate histones R-HSA-3214842 9.699408e-02 1.013 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.829685e-02 1.007 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.829685e-02 1.007 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.829685e-02 1.007 0 0
Signaling by ROBO receptors R-HSA-376176 1.000677e-01 1.000 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.005529e-01 0.998 0 0
Signaling by ALK in cancer R-HSA-9700206 1.005529e-01 0.998 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.007566e-01 0.997 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.007566e-01 0.997 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.007566e-01 0.997 0 0
Signaling by RAS mutants R-HSA-6802949 1.007566e-01 0.997 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.007566e-01 0.997 0 0
Type I hemidesmosome assembly R-HSA-446107 1.014138e-01 0.994 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.014138e-01 0.994 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.014138e-01 0.994 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.014138e-01 0.994 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.014138e-01 0.994 0 0
G2/M Transition R-HSA-69275 1.019825e-01 0.991 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.019974e-01 0.991 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.035762e-01 0.985 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.035762e-01 0.985 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.035762e-01 0.985 0 0
Lipophagy R-HSA-9613354 1.226701e-01 0.911 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.226701e-01 0.911 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.226701e-01 0.911 0 0
PI3K/AKT activation R-HSA-198203 1.453776e-01 0.838 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.279641e-01 0.893 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.279641e-01 0.893 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.458487e-01 0.836 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.255639e-01 0.901 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.403681e-01 0.853 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.403681e-01 0.853 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.203153e-01 0.920 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.558916e-01 0.807 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.461328e-01 0.835 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.363846e-01 0.865 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.375288e-01 0.862 0 0
HCMV Early Events R-HSA-9609690 1.072314e-01 0.970 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.073523e-01 0.969 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.472805e-01 0.832 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.337130e-01 0.874 0 0
Aggrephagy R-HSA-9646399 1.073523e-01 0.969 0 0
Nephrin family interactions R-HSA-373753 1.115262e-01 0.953 0 0
EPH-Ephrin signaling R-HSA-2682334 1.566486e-01 0.805 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.226701e-01 0.911 0 0
DCC mediated attractive signaling R-HSA-418885 1.279641e-01 0.893 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.170631e-01 0.932 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.083307e-01 0.965 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.239540e-01 0.907 0 0
S Phase R-HSA-69242 1.233297e-01 0.909 0 0
Calcineurin activates NFAT R-HSA-2025928 1.226701e-01 0.911 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.163593e-01 0.934 0 0
mTORC1-mediated signalling R-HSA-166208 1.558916e-01 0.807 0 0
Mitophagy R-HSA-5205647 1.249320e-01 0.903 0 0
Selective autophagy R-HSA-9663891 1.195396e-01 0.922 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.110738e-01 0.954 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.249320e-01 0.903 0 0
Glycogen synthesis R-HSA-3322077 1.115262e-01 0.953 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.105156e-01 0.957 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.203153e-01 0.920 0 0
Signaling by MET R-HSA-6806834 1.147149e-01 0.940 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.226701e-01 0.911 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.275331e-01 0.894 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.275331e-01 0.894 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.529064e-01 0.816 1 1
Signaling by FGFR4 R-HSA-5654743 1.484460e-01 0.828 0 0
TRP channels R-HSA-3295583 1.083307e-01 0.965 0 0
Developmental Biology R-HSA-1266738 1.280200e-01 0.893 1 0
DARPP-32 events R-HSA-180024 1.461328e-01 0.835 1 1
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.139908e-01 0.943 0 0
Signaling by FGFR R-HSA-190236 1.446857e-01 0.840 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.453776e-01 0.838 0 0
Signaling by ERBB4 R-HSA-1236394 1.318207e-01 0.880 0 0
PI Metabolism R-HSA-1483255 1.144871e-01 0.941 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.453776e-01 0.838 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.183140e-01 0.927 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.255639e-01 0.901 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.176136e-01 0.930 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.363846e-01 0.865 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.399557e-01 0.854 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.090396e-01 0.962 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.558916e-01 0.807 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.110738e-01 0.954 0 0
G1/S-Specific Transcription R-HSA-69205 1.483305e-01 0.829 0 0
Signaling by Leptin R-HSA-2586552 1.453776e-01 0.838 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.279641e-01 0.893 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.458487e-01 0.836 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.403681e-01 0.853 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.411379e-01 0.850 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.279641e-01 0.893 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.322324e-01 0.879 0 0
Regulation of BACH1 activity R-HSA-9708530 1.458487e-01 0.836 0 0
Interleukin-12 family signaling R-HSA-447115 1.127957e-01 0.948 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.576957e-01 0.802 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.576957e-01 0.802 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.578555e-01 0.802 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.578555e-01 0.802 0 0
IRS activation R-HSA-74713 1.578555e-01 0.802 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.578555e-01 0.802 0 0
Glycolysis R-HSA-70171 1.597293e-01 0.797 1 0
Activation of the pre-replicative complex R-HSA-68962 1.599096e-01 0.796 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.599096e-01 0.796 0 0
Degradation of DVL R-HSA-4641258 1.607497e-01 0.794 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.607497e-01 0.794 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.612634e-01 0.792 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.646372e-01 0.783 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.646372e-01 0.783 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.646372e-01 0.783 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.659216e-01 0.780 0 0
Host Interactions of HIV factors R-HSA-162909 1.660342e-01 0.780 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.684568e-01 0.774 0 0
PTEN Regulation R-HSA-6807070 1.684892e-01 0.773 0 0
Signaling by APC mutants R-HSA-4839744 1.693258e-01 0.771 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.693258e-01 0.771 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.693258e-01 0.771 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.693258e-01 0.771 0 0
Interleukin-2 signaling R-HSA-9020558 1.693258e-01 0.771 0 0
Synthesis of PI R-HSA-1483226 1.693258e-01 0.771 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.714848e-01 0.766 0 0
DAG and IP3 signaling R-HSA-1489509 1.714848e-01 0.766 1 0
Signaling by FGFR3 R-HSA-5654741 1.714848e-01 0.766 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.720835e-01 0.764 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.742228e-01 0.759 0 0
HIV Infection R-HSA-162906 1.755409e-01 0.756 0 0
Post NMDA receptor activation events R-HSA-438064 1.786586e-01 0.748 1 0
Pyruvate metabolism R-HSA-70268 1.786586e-01 0.748 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.810095e-01 0.742 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.826714e-01 0.738 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.826714e-01 0.738 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.826714e-01 0.738 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.826714e-01 0.738 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.826714e-01 0.738 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 1.826714e-01 0.738 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.826714e-01 0.738 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.826714e-01 0.738 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.826714e-01 0.738 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.826714e-01 0.738 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.826714e-01 0.738 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.826714e-01 0.738 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.835733e-01 0.736 0 0
Diseases of DNA repair R-HSA-9675135 1.835733e-01 0.736 0 0
Semaphorin interactions R-HSA-373755 1.857043e-01 0.731 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.857043e-01 0.731 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.869172e-01 0.728 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.869172e-01 0.728 0 0
G0 and Early G1 R-HSA-1538133 1.890374e-01 0.723 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.936333e-01 0.713 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.936333e-01 0.713 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.936392e-01 0.713 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.936392e-01 0.713 0 0
Phosphorylation of Emi1 R-HSA-176417 1.936392e-01 0.713 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.936392e-01 0.713 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.936392e-01 0.713 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.936392e-01 0.713 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.936392e-01 0.713 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.943061e-01 0.712 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.943061e-01 0.712 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.943061e-01 0.712 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.963600e-01 0.707 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.610910e-01 0.583 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.610910e-01 0.583 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.610910e-01 0.583 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.610910e-01 0.583 0 0
Intestinal infectious diseases R-HSA-8942233 2.610910e-01 0.583 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.610910e-01 0.583 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.610910e-01 0.583 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.610910e-01 0.583 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.610910e-01 0.583 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.610910e-01 0.583 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.319907e-01 0.479 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.319907e-01 0.479 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.319907e-01 0.479 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.319907e-01 0.479 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.319907e-01 0.479 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.319907e-01 0.479 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.319907e-01 0.479 0 0
STAT5 Activation R-HSA-9645135 2.303111e-01 0.638 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.303111e-01 0.638 0 0
SOS-mediated signalling R-HSA-112412 2.673719e-01 0.573 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.673719e-01 0.573 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 3.960912e-01 0.402 0 0
Axonal growth stimulation R-HSA-209563 3.960912e-01 0.402 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.960912e-01 0.402 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 3.960912e-01 0.402 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.960912e-01 0.402 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 3.960912e-01 0.402 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.960912e-01 0.402 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 3.960912e-01 0.402 0 0
Classical Kir channels R-HSA-1296053 3.960912e-01 0.402 0 0
Invadopodia formation R-HSA-8941237 3.960912e-01 0.402 0 0
Defective ABCA1 causes TGD R-HSA-5682113 3.960912e-01 0.402 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.045434e-01 0.689 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.254647e-01 0.647 0 0
Removal of the Flap Intermediate R-HSA-69166 2.734554e-01 0.563 0 0
ALK mutants bind TKIs R-HSA-9700645 3.410878e-01 0.467 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.469001e-01 0.607 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.469001e-01 0.607 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.469001e-01 0.607 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.469001e-01 0.607 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.006320e-01 0.522 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.687524e-01 0.571 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.771347e-01 0.424 0 0
Cristae formation R-HSA-8949613 2.424150e-01 0.615 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.909270e-01 0.536 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.610942e-01 0.583 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.610942e-01 0.583 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.610942e-01 0.583 0 0
Dual Incision in GG-NER R-HSA-5696400 2.361121e-01 0.627 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.291074e-01 0.640 1 1
Degradation of GLI2 by the proteasome R-HSA-5610783 2.291074e-01 0.640 1 1
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.525481e-01 0.598 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.800919e-01 0.553 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.993485e-01 0.524 0 0
Degradation of AXIN R-HSA-4641257 2.862897e-01 0.543 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.823407e-01 0.418 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.823407e-01 0.418 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.823407e-01 0.418 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.584914e-01 0.446 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.896479e-01 0.538 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.769571e-01 0.558 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.209139e-01 0.494 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.053465e-01 0.515 0 0
Translation initiation complex formation R-HSA-72649 2.912823e-01 0.536 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.810837e-01 0.419 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.258239e-01 0.646 0 0
HIV Transcription Elongation R-HSA-167169 3.384544e-01 0.470 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.384544e-01 0.470 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.384544e-01 0.470 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.918012e-01 0.535 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.918012e-01 0.535 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.366368e-01 0.626 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.204346e-01 0.494 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.668329e-01 0.574 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.042770e-01 0.517 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.327824e-01 0.478 0 0
Centrosome maturation R-HSA-380287 3.300829e-01 0.481 0 0
Peptide chain elongation R-HSA-156902 3.896911e-01 0.409 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.836800e-01 0.416 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.242857e-01 0.649 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.358333e-01 0.474 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.560937e-01 0.448 0 0
MET promotes cell motility R-HSA-8875878 3.035122e-01 0.518 0 0
DNA Damage Bypass R-HSA-73893 3.533005e-01 0.452 0 0
FOXO-mediated transcription R-HSA-9614085 2.268308e-01 0.644 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.358333e-01 0.474 0 0
Cellular response to hypoxia R-HSA-1234174 3.189941e-01 0.496 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.469001e-01 0.607 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.006320e-01 0.522 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.823407e-01 0.418 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.896479e-01 0.538 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.771347e-01 0.424 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.500946e-01 0.456 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.856832e-01 0.414 0 0
Apoptotic factor-mediated response R-HSA-111471 2.045434e-01 0.689 0 0
Developmental Cell Lineages R-HSA-9734767 2.232006e-01 0.651 0 0
Formation of apoptosome R-HSA-111458 3.771347e-01 0.424 0 0
Regulation of Apoptosis R-HSA-169911 2.525481e-01 0.598 0 0
DNA strand elongation R-HSA-69190 3.384063e-01 0.471 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.384063e-01 0.471 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.384063e-01 0.471 0 0
Pyroptosis R-HSA-5620971 2.610942e-01 0.583 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.882355e-01 0.540 0 0
Recycling pathway of L1 R-HSA-437239 3.212085e-01 0.493 0 0
Synthesis of DNA R-HSA-69239 2.274156e-01 0.643 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.939844e-01 0.405 0 0
G1 Phase R-HSA-69236 2.741439e-01 0.562 0 0
Cyclin D associated events in G1 R-HSA-69231 2.741439e-01 0.562 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.112954e-01 0.675 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.201154e-01 0.657 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.692878e-01 0.570 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.560937e-01 0.448 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.584914e-01 0.446 1 1
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.960642e-01 0.402 0 0
Adipogenesis R-HSA-9843745 2.356685e-01 0.628 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.560770e-01 0.592 1 0
HCMV Infection R-HSA-9609646 2.575831e-01 0.589 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.560937e-01 0.448 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.560937e-01 0.448 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.289281e-01 0.483 0 0
Signaling by Hedgehog R-HSA-5358351 3.061205e-01 0.514 1 0
Signaling by WNT in cancer R-HSA-4791275 3.384063e-01 0.471 0 0
Frs2-mediated activation R-HSA-170968 2.465596e-01 0.608 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.062526e-01 0.686 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.584914e-01 0.446 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.303111e-01 0.638 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.384544e-01 0.470 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.384544e-01 0.470 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.560937e-01 0.448 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.774259e-01 0.423 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.810837e-01 0.419 0 0
Cardiac conduction R-HSA-5576891 2.356685e-01 0.628 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.957202e-01 0.403 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.737929e-01 0.427 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.769571e-01 0.558 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.939368e-01 0.405 0 0
Prolonged ERK activation events R-HSA-169893 3.279319e-01 0.484 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.580952e-01 0.446 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.752686e-01 0.426 0 0
Interleukin-33 signaling R-HSA-9014843 3.319907e-01 0.479 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.319907e-01 0.479 0 0
MET interacts with TNS proteins R-HSA-8875513 3.960912e-01 0.402 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.044096e-01 0.517 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.465596e-01 0.608 1 1
Regulation of KIT signaling R-HSA-1433559 2.734554e-01 0.563 0 0
Unwinding of DNA R-HSA-176974 3.410878e-01 0.467 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.771347e-01 0.424 0 0
Notch-HLH transcription pathway R-HSA-350054 3.133326e-01 0.504 0 0
PLC beta mediated events R-HSA-112043 2.652504e-01 0.576 1 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.666027e-01 0.574 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.580952e-01 0.446 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.384544e-01 0.470 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.951196e-01 0.403 0 0
MAPK family signaling cascades R-HSA-5683057 2.241718e-01 0.649 1 0
Calmodulin induced events R-HSA-111933 2.692878e-01 0.570 1 0
CaM pathway R-HSA-111997 2.692878e-01 0.570 1 0
Adaptive Immune System R-HSA-1280218 2.751737e-01 0.560 1 0
Signal attenuation R-HSA-74749 3.771347e-01 0.424 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.909270e-01 0.536 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.858825e-01 0.414 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.212085e-01 0.493 0 0
Ca-dependent events R-HSA-111996 3.915145e-01 0.407 1 0
Interleukin-1 family signaling R-HSA-446652 2.747270e-01 0.561 0 0
Nef and signal transduction R-HSA-164944 2.303111e-01 0.638 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.673719e-01 0.573 0 0
CHL1 interactions R-HSA-447041 2.673719e-01 0.573 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.044096e-01 0.517 0 0
Interleukin-1 processing R-HSA-448706 3.410878e-01 0.467 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.410878e-01 0.467 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.410878e-01 0.467 0 0
Protein hydroxylation R-HSA-9629569 2.469001e-01 0.607 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.823407e-01 0.418 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.784358e-01 0.555 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.778194e-01 0.423 0 0
Signaling by FGFR1 R-HSA-5654736 2.026814e-01 0.693 0 0
G-protein mediated events R-HSA-112040 3.466726e-01 0.460 1 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.410878e-01 0.467 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.045434e-01 0.689 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.578290e-01 0.446 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.043164e-01 0.690 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.610910e-01 0.583 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.960912e-01 0.402 0 0
Physiological factors R-HSA-5578768 2.734554e-01 0.563 0 0
ARMS-mediated activation R-HSA-170984 3.410878e-01 0.467 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.410878e-01 0.467 0 0
Protein methylation R-HSA-8876725 3.006320e-01 0.522 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.771347e-01 0.424 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.279319e-01 0.484 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.384544e-01 0.470 0 0
Opioid Signalling R-HSA-111885 3.779808e-01 0.423 1 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.133326e-01 0.504 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.784358e-01 0.555 0 0
Signal regulatory protein family interactions R-HSA-391160 2.734554e-01 0.563 0 0
Signaling by TGFB family members R-HSA-9006936 3.442660e-01 0.463 0 0
Histamine receptors R-HSA-390650 3.960912e-01 0.402 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.771347e-01 0.424 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.606450e-01 0.443 0 0
Signaling by NOTCH2 R-HSA-1980145 2.361121e-01 0.627 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.552114e-01 0.450 0 0
Stabilization of p53 R-HSA-69541 3.209139e-01 0.494 0 0
Formation of the nephric duct R-HSA-9830364 3.810837e-01 0.419 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.673719e-01 0.573 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.673719e-01 0.573 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.960912e-01 0.402 0 0
Sodium/Proton exchangers R-HSA-425986 3.044096e-01 0.517 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.771347e-01 0.424 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.279319e-01 0.484 1 1
Interactions of Vpr with host cellular proteins R-HSA-176033 2.006158e-01 0.698 0 0
Assembly Of The HIV Virion R-HSA-175474 2.909270e-01 0.536 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.146886e-01 0.668 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.580952e-01 0.446 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.762655e-01 0.425 0 0
Interleukin-7 signaling R-HSA-1266695 2.062526e-01 0.686 0 0
Inositol phosphate metabolism R-HSA-1483249 3.725539e-01 0.429 0 0
Glucose metabolism R-HSA-70326 3.462832e-01 0.461 1 0
PKR-mediated signaling R-HSA-9833482 3.960642e-01 0.402 0 0
Signaling by Interleukins R-HSA-449147 2.865095e-01 0.543 0 0
Influenza Infection R-HSA-168255 3.530937e-01 0.452 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.465596e-01 0.608 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.410878e-01 0.467 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.687524e-01 0.571 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.687524e-01 0.571 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.835959e-01 0.416 0 0
Translation of Structural Proteins R-HSA-9683701 3.737929e-01 0.427 0 0
Ribosome-associated quality control R-HSA-9948299 3.973876e-01 0.401 0 0
RAF activation R-HSA-5673000 3.975283e-01 0.401 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.975283e-01 0.401 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.975283e-01 0.401 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.975283e-01 0.401 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.975283e-01 0.401 0 0
Nucleotide Excision Repair R-HSA-5696398 4.010374e-01 0.397 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.035857e-01 0.394 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.057886e-01 0.392 0 0
Ephrin signaling R-HSA-3928664 4.092039e-01 0.388 0 0
GAB1 signalosome R-HSA-180292 4.092039e-01 0.388 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.092039e-01 0.388 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.092039e-01 0.388 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.092039e-01 0.388 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.092039e-01 0.388 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.092039e-01 0.388 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.092039e-01 0.388 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.092222e-01 0.388 0 0
TBC/RABGAPs R-HSA-8854214 4.092222e-01 0.388 0 0
Signaling by SCF-KIT R-HSA-1433557 4.092222e-01 0.388 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.101783e-01 0.387 0 0
tRNA processing in the nucleus R-HSA-6784531 4.101783e-01 0.387 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.123339e-01 0.385 0 0
Prostanoid ligand receptors R-HSA-391908 4.123339e-01 0.385 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.142149e-01 0.383 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.171736e-01 0.380 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.171736e-01 0.380 0 0
PERK regulates gene expression R-HSA-381042 4.171736e-01 0.380 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.259300e-01 0.371 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.259300e-01 0.371 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.259300e-01 0.371 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.259300e-01 0.371 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.260162e-01 0.371 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.268813e-01 0.370 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.276358e-01 0.369 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.343017e-01 0.362 0 0
Specification of the neural plate border R-HSA-9834899 4.356984e-01 0.361 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.356984e-01 0.361 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.356984e-01 0.361 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.367102e-01 0.360 0 0
RNA Polymerase III Transcription R-HSA-74158 4.367102e-01 0.360 0 0
GPVI-mediated activation cascade R-HSA-114604 4.367102e-01 0.360 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.424549e-01 0.354 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.444586e-01 0.352 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.444586e-01 0.352 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.444586e-01 0.352 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.444586e-01 0.352 0 0
Signaling by NOTCH4 R-HSA-9013694 4.451474e-01 0.351 0 0
Signaling by FGFR in disease R-HSA-1226099 4.451474e-01 0.351 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.465163e-01 0.350 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.465163e-01 0.350 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.465163e-01 0.350 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.465163e-01 0.350 0 0
HIV elongation arrest and recovery R-HSA-167287 4.480545e-01 0.349 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.480545e-01 0.349 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.480545e-01 0.349 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.529040e-01 0.344 0 0
Vesicle-mediated transport R-HSA-5653656 4.533973e-01 0.344 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.540443e-01 0.343 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.540443e-01 0.343 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.540443e-01 0.343 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.540443e-01 0.343 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.540443e-01 0.343 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 4.540443e-01 0.343 0 0
Regulation of gap junction activity R-HSA-191650 4.540443e-01 0.343 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.540443e-01 0.343 0 0
Transmission across Electrical Synapses R-HSA-112307 4.540443e-01 0.343 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.540443e-01 0.343 0 0
Alanine metabolism R-HSA-8964540 4.540443e-01 0.343 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.540443e-01 0.343 0 0
Sensory perception of sour taste R-HSA-9729555 4.540443e-01 0.343 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.540443e-01 0.343 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.540443e-01 0.343 0 0
Dopamine receptors R-HSA-390651 4.540443e-01 0.343 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.542056e-01 0.343 1 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.560954e-01 0.341 0 0
TCR signaling R-HSA-202403 4.588665e-01 0.338 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.617345e-01 0.336 0 0
Formation of definitive endoderm R-HSA-9823730 4.617345e-01 0.336 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.619226e-01 0.335 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.619226e-01 0.335 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.664336e-01 0.331 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.664336e-01 0.331 0 0
Ion homeostasis R-HSA-5578775 4.664336e-01 0.331 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.666950e-01 0.331 0 0
Signaling by Erythropoietin R-HSA-9006335 4.699027e-01 0.328 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.699027e-01 0.328 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.757518e-01 0.323 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.792437e-01 0.319 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.792437e-01 0.319 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.795531e-01 0.319 0 0
Polymerase switching R-HSA-69091 4.795531e-01 0.319 0 0
Leading Strand Synthesis R-HSA-69109 4.795531e-01 0.319 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.795531e-01 0.319 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.795531e-01 0.319 0 0
Repression of WNT target genes R-HSA-4641265 4.795531e-01 0.319 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.795531e-01 0.319 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.795531e-01 0.319 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.795531e-01 0.319 0 0
OAS antiviral response R-HSA-8983711 4.795531e-01 0.319 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.863976e-01 0.313 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.870241e-01 0.312 0 0
Lagging Strand Synthesis R-HSA-69186 4.872348e-01 0.312 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.872348e-01 0.312 1 1
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.914237e-01 0.309 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.919793e-01 0.308 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.942565e-01 0.306 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.942565e-01 0.306 0 0
Co-stimulation by CD28 R-HSA-389356 4.963940e-01 0.304 0 0
Dual incision in TC-NER R-HSA-6782135 4.981158e-01 0.303 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.981158e-01 0.303 0 0
Transcription of the HIV genome R-HSA-167172 4.995635e-01 0.301 0 0
PCP/CE pathway R-HSA-4086400 5.008178e-01 0.300 0 0
ABC transporter disorders R-HSA-5619084 5.008178e-01 0.300 0 0
RSV-host interactions R-HSA-9833110 5.038424e-01 0.298 0 0
Interferon Signaling R-HSA-913531 5.053807e-01 0.296 0 0
Activation of AMPA receptors R-HSA-399710 5.064390e-01 0.295 0 0
Defective F9 activation R-HSA-9673221 5.064390e-01 0.295 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.064390e-01 0.295 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.064390e-01 0.295 0 0
Reelin signalling pathway R-HSA-8866376 5.064390e-01 0.295 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.064390e-01 0.295 0 0
PTK6 Down-Regulation R-HSA-8849472 5.064390e-01 0.295 0 0
Hydroxycarboxylic acid-binding receptors R-HSA-3296197 5.064390e-01 0.295 0 0
Interleukin-36 pathway R-HSA-9014826 5.064390e-01 0.295 0 0
NrCAM interactions R-HSA-447038 5.064390e-01 0.295 0 0
Co-inhibition by BTLA R-HSA-9927353 5.064390e-01 0.295 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.064390e-01 0.295 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.113493e-01 0.291 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.113493e-01 0.291 0 0
Formation of axial mesoderm R-HSA-9796292 5.113493e-01 0.291 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.113493e-01 0.291 0 0
Maturation of nucleoprotein R-HSA-9683610 5.113493e-01 0.291 0 0
Interleukin-6 signaling R-HSA-1059683 5.113493e-01 0.291 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.121334e-01 0.291 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.121334e-01 0.291 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.129622e-01 0.290 0 0
Degradation of CDH1 R-HSA-9766229 5.133476e-01 0.290 0 0
Gap junction trafficking and regulation R-HSA-157858 5.133476e-01 0.290 0 0
Sensory processing of sound R-HSA-9659379 5.145043e-01 0.289 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.148855e-01 0.288 0 0
SARS-CoV Infections R-HSA-9679506 5.232096e-01 0.281 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.271947e-01 0.278 0 0
Potential therapeutics for SARS R-HSA-9679191 5.272356e-01 0.278 0 0
Ion channel transport R-HSA-983712 5.275786e-01 0.278 0 0
PI3K Cascade R-HSA-109704 5.300804e-01 0.276 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.313761e-01 0.275 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.363751e-01 0.271 0 0
LDL clearance R-HSA-8964038 5.363751e-01 0.271 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.363751e-01 0.271 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.418388e-01 0.266 0 0
HDL assembly R-HSA-8963896 5.418388e-01 0.266 1 1
cGMP effects R-HSA-418457 5.418388e-01 0.266 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 5.418388e-01 0.266 0 0
Glycerophospholipid catabolism R-HSA-6814848 5.418388e-01 0.266 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.418388e-01 0.266 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.418388e-01 0.266 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.427864e-01 0.265 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.427864e-01 0.265 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.444262e-01 0.264 0 0
MAP kinase activation R-HSA-450294 5.444262e-01 0.264 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.465702e-01 0.262 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.467059e-01 0.262 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.494706e-01 0.260 0 0
L1CAM interactions R-HSA-373760 5.494921e-01 0.260 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.535924e-01 0.257 0 0
Integrin signaling R-HSA-354192 5.535924e-01 0.257 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.535924e-01 0.257 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.535924e-01 0.257 0 0
Cardiogenesis R-HSA-9733709 5.535924e-01 0.257 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.538083e-01 0.257 0 0
PKB-mediated events R-HSA-109703 5.538083e-01 0.257 0 0
Cam-PDE 1 activation R-HSA-111957 5.538083e-01 0.257 0 0
PDE3B signalling R-HSA-165160 5.538083e-01 0.257 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.538083e-01 0.257 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.538083e-01 0.257 0 0
Signaling by MST1 R-HSA-8852405 5.538083e-01 0.257 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.538083e-01 0.257 0 0
Synthesis of PS R-HSA-1483101 5.538083e-01 0.257 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.538083e-01 0.257 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.538083e-01 0.257 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.538083e-01 0.257 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.538083e-01 0.257 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.538083e-01 0.257 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.538083e-01 0.257 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.538083e-01 0.257 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.627968e-01 0.250 0 0
Ca2+ pathway R-HSA-4086398 5.707603e-01 0.244 0 0
Erythropoietin activates RAS R-HSA-9027284 5.709796e-01 0.243 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.709796e-01 0.243 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.709796e-01 0.243 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.709796e-01 0.243 0 0
DNA Damage Reversal R-HSA-73942 5.709796e-01 0.243 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.709796e-01 0.243 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.709796e-01 0.243 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.730110e-01 0.242 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.733990e-01 0.242 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.733990e-01 0.242 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.733990e-01 0.242 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.753760e-01 0.240 0 0
Interleukin-1 signaling R-HSA-9020702 5.753760e-01 0.240 0 0
Selenocysteine synthesis R-HSA-2408557 5.753760e-01 0.240 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.787416e-01 0.238 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.827162e-01 0.235 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.827162e-01 0.235 0 0
Deadenylation of mRNA R-HSA-429947 5.827162e-01 0.235 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.846050e-01 0.233 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.927004e-01 0.227 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.966339e-01 0.224 0 0
CREB phosphorylation R-HSA-199920 5.966339e-01 0.224 0 0
Hydrolysis of LPE R-HSA-1483152 5.966339e-01 0.224 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.966339e-01 0.224 0 0
Neurofascin interactions R-HSA-447043 5.966339e-01 0.224 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.966339e-01 0.224 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.966339e-01 0.224 0 0
Chylomicron clearance R-HSA-8964026 5.966339e-01 0.224 0 0
Lipid particle organization R-HSA-8964572 5.966339e-01 0.224 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.987497e-01 0.223 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.987497e-01 0.223 0 0
Phosphorylation of the APC/C R-HSA-176412 5.987497e-01 0.223 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.987497e-01 0.223 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.987497e-01 0.223 0 0
Killing mechanisms R-HSA-9664420 5.987497e-01 0.223 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.987497e-01 0.223 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 5.987497e-01 0.223 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.006409e-01 0.221 0 0
Gap junction trafficking R-HSA-190828 6.016037e-01 0.221 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.020791e-01 0.220 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.047518e-01 0.218 0 0
Tight junction interactions R-HSA-420029 6.047518e-01 0.218 0 0
Long-term potentiation R-HSA-9620244 6.047518e-01 0.218 0 0
TGFBR3 expression R-HSA-9839394 6.047518e-01 0.218 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.097214e-01 0.215 0 0
Signaling by NOTCH3 R-HSA-9012852 6.097214e-01 0.215 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.098870e-01 0.215 1 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.171804e-01 0.210 1 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.182003e-01 0.209 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.182003e-01 0.209 1 1
MHC class II antigen presentation R-HSA-2132295 6.240389e-01 0.205 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.240389e-01 0.205 0 0
Translation of Structural Proteins R-HSA-9694635 6.242334e-01 0.205 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.247285e-01 0.204 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.251439e-01 0.204 0 0
Phase 2 - plateau phase R-HSA-5576893 6.251439e-01 0.204 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.251439e-01 0.204 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.251439e-01 0.204 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.251439e-01 0.204 0 0
Disorders of Developmental Biology R-HSA-9675151 6.251439e-01 0.204 0 0
Passive transport by Aquaporins R-HSA-432047 6.251439e-01 0.204 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.255823e-01 0.204 0 0
Eukaryotic Translation Termination R-HSA-72764 6.255823e-01 0.204 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.260012e-01 0.203 0 0
Myogenesis R-HSA-525793 6.260012e-01 0.203 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.260012e-01 0.203 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.260012e-01 0.203 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.260012e-01 0.203 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.260012e-01 0.203 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.334766e-01 0.198 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.343809e-01 0.198 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.353514e-01 0.197 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.353514e-01 0.197 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.353514e-01 0.197 0 0
Recycling of eIF2:GDP R-HSA-72731 6.353514e-01 0.197 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.353514e-01 0.197 0 0
PTK6 Expression R-HSA-8849473 6.353514e-01 0.197 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.353514e-01 0.197 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.353514e-01 0.197 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.353514e-01 0.197 0 0
VLDL clearance R-HSA-8964046 6.353514e-01 0.197 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.353514e-01 0.197 0 0
Netrin mediated repulsion signals R-HSA-418886 6.353514e-01 0.197 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.353514e-01 0.197 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.353514e-01 0.197 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.383099e-01 0.195 0 0
IRS-mediated signalling R-HSA-112399 6.393982e-01 0.194 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.445004e-01 0.191 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.464513e-01 0.189 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.464513e-01 0.189 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.464513e-01 0.189 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.501702e-01 0.187 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.501702e-01 0.187 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.501702e-01 0.187 0 0
Specification of primordial germ cells R-HSA-9827857 6.501702e-01 0.187 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.537205e-01 0.185 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.594361e-01 0.181 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.594361e-01 0.181 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.594361e-01 0.181 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.618642e-01 0.179 1 1
Downstream TCR signaling R-HSA-202424 6.660928e-01 0.176 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.660945e-01 0.176 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.676875e-01 0.175 0 0
Mitochondrial biogenesis R-HSA-1592230 6.688250e-01 0.175 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.703545e-01 0.174 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.703545e-01 0.174 0 0
MET receptor recycling R-HSA-8875656 6.703545e-01 0.174 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.703545e-01 0.174 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.703545e-01 0.174 0 0
Adrenoceptors R-HSA-390696 6.703545e-01 0.174 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.703545e-01 0.174 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.703545e-01 0.174 1 1
Interleukin-17 signaling R-HSA-448424 6.706041e-01 0.174 0 0
Platelet degranulation R-HSA-114608 6.733349e-01 0.172 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.738482e-01 0.171 0 0
PKA activation R-HSA-163615 6.738482e-01 0.171 1 1
PKA activation in glucagon signalling R-HSA-164378 6.738482e-01 0.171 1 1
Platelet sensitization by LDL R-HSA-432142 6.738482e-01 0.171 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.738482e-01 0.171 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.803199e-01 0.167 0 0
ABC-family proteins mediated transport R-HSA-382556 6.810067e-01 0.167 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.810091e-01 0.167 0 0
Signaling by ALK R-HSA-201556 6.810091e-01 0.167 0 0
RAS processing R-HSA-9648002 6.810091e-01 0.167 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.810091e-01 0.167 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.846651e-01 0.165 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.846651e-01 0.165 0 0
mRNA Capping R-HSA-72086 6.849291e-01 0.164 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.849291e-01 0.164 0 0
Platelet calcium homeostasis R-HSA-418360 6.849291e-01 0.164 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.883339e-01 0.162 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.945299e-01 0.158 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.962060e-01 0.157 0 0
The NLRP3 inflammasome R-HSA-844456 6.962060e-01 0.157 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.962060e-01 0.157 0 0
Maturation of nucleoprotein R-HSA-9694631 6.962060e-01 0.157 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.962060e-01 0.157 0 0
Generation of second messenger molecules R-HSA-202433 6.969585e-01 0.157 0 0
Interleukin-2 family signaling R-HSA-451927 6.969585e-01 0.157 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.991955e-01 0.155 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.992996e-01 0.155 1 0
WNT mediated activation of DVL R-HSA-201688 7.019996e-01 0.154 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.019996e-01 0.154 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.019996e-01 0.154 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.019996e-01 0.154 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.019996e-01 0.154 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.019996e-01 0.154 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.019996e-01 0.154 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.019996e-01 0.154 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.029579e-01 0.153 0 0
DAP12 signaling R-HSA-2424491 7.029579e-01 0.153 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.029579e-01 0.153 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.029579e-01 0.153 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.071445e-01 0.150 0 0
Heme signaling R-HSA-9707616 7.073962e-01 0.150 0 0
Viral mRNA Translation R-HSA-192823 7.117815e-01 0.148 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.140226e-01 0.146 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.172789e-01 0.144 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.172789e-01 0.144 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.172789e-01 0.144 0 0
Trafficking of AMPA receptors R-HSA-399719 7.201878e-01 0.143 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.271180e-01 0.138 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.271180e-01 0.138 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.271180e-01 0.138 0 0
Circadian clock R-HSA-9909396 7.273412e-01 0.138 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.304474e-01 0.136 0 0
Iron uptake and transport R-HSA-917937 7.304474e-01 0.136 0 0
DNA replication initiation R-HSA-68952 7.306085e-01 0.136 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.306085e-01 0.136 0 0
Regulation of CDH11 function R-HSA-9762292 7.306085e-01 0.136 0 0
Binding and entry of HIV virion R-HSA-173107 7.306085e-01 0.136 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.306085e-01 0.136 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.306085e-01 0.136 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.306085e-01 0.136 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.306085e-01 0.136 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.306085e-01 0.136 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.306085e-01 0.136 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.306085e-01 0.136 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.306085e-01 0.136 0 0
IGF1R signaling cascade R-HSA-2428924 7.320061e-01 0.135 0 0
Insulin receptor signalling cascade R-HSA-74751 7.320061e-01 0.135 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.357606e-01 0.133 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.371074e-01 0.132 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.371074e-01 0.132 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.371074e-01 0.132 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.404052e-01 0.131 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.405928e-01 0.130 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.413329e-01 0.130 1 1
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.414308e-01 0.130 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.437479e-01 0.129 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.478845e-01 0.126 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.522964e-01 0.124 0 0
G-protein beta:gamma signalling R-HSA-397795 7.522964e-01 0.124 0 0
Neuronal System R-HSA-112316 7.532640e-01 0.123 1 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.557362e-01 0.122 0 0
Attachment and Entry R-HSA-9694614 7.557362e-01 0.122 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.557362e-01 0.122 0 0
vRNP Assembly R-HSA-192905 7.564724e-01 0.121 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.564724e-01 0.121 0 0
Bicarbonate transporters R-HSA-425381 7.564724e-01 0.121 0 0
Transport of RCbl within the body R-HSA-9758890 7.564724e-01 0.121 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.564724e-01 0.121 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.564724e-01 0.121 0 0
PECAM1 interactions R-HSA-210990 7.564724e-01 0.121 0 0
Suppression of apoptosis R-HSA-9635465 7.564724e-01 0.121 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.586884e-01 0.120 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.625329e-01 0.118 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.666534e-01 0.115 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.672050e-01 0.115 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.674009e-01 0.115 0 0
DAP12 interactions R-HSA-2172127 7.680608e-01 0.115 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.732129e-01 0.112 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.732129e-01 0.112 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.732129e-01 0.112 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.758900e-01 0.110 0 0
Cilium Assembly R-HSA-5617833 7.796642e-01 0.108 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.798545e-01 0.108 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.798545e-01 0.108 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.798545e-01 0.108 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.798545e-01 0.108 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.798545e-01 0.108 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.798545e-01 0.108 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.798545e-01 0.108 0 0
Activation of RAC1 R-HSA-428540 7.798545e-01 0.108 0 0
Sodium/Calcium exchangers R-HSA-425561 7.798545e-01 0.108 0 0
Signal amplification R-HSA-392518 7.813738e-01 0.107 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.813738e-01 0.107 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.881887e-01 0.103 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.895869e-01 0.103 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.895869e-01 0.103 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 7.895869e-01 0.103 0 0
Syndecan interactions R-HSA-3000170 7.895869e-01 0.103 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.895869e-01 0.103 0 0
Growth hormone receptor signaling R-HSA-982772 7.895869e-01 0.103 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.898921e-01 0.102 0 0
Signaling by TGFBR3 R-HSA-9839373 7.925761e-01 0.101 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.934051e-01 0.101 0 0
Signalling to ERKs R-HSA-187687 7.948228e-01 0.100 0 0
IRE1alpha activates chaperones R-HSA-381070 7.969152e-01 0.099 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.969364e-01 0.099 0 0
Leishmania phagocytosis R-HSA-9664417 7.969364e-01 0.099 0 0
Parasite infection R-HSA-9664407 7.969364e-01 0.099 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.009929e-01 0.096 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.009929e-01 0.096 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.009929e-01 0.096 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.009929e-01 0.096 0 0
Signaling by LTK R-HSA-9842663 8.009929e-01 0.096 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.009929e-01 0.096 0 0
Regulation of IFNG signaling R-HSA-877312 8.009929e-01 0.096 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.009929e-01 0.096 0 0
Pervasive developmental disorders R-HSA-9005895 8.009929e-01 0.096 0 0
Disorders of Nervous System Development R-HSA-9697154 8.009929e-01 0.096 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.009929e-01 0.096 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.009929e-01 0.096 0 0
Estrogen biosynthesis R-HSA-193144 8.009929e-01 0.096 0 0
Interleukin-15 signaling R-HSA-8983432 8.009929e-01 0.096 0 0
Extension of Telomeres R-HSA-180786 8.042449e-01 0.095 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.049088e-01 0.094 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.049088e-01 0.094 1 0
Interleukin-6 family signaling R-HSA-6783589 8.049088e-01 0.094 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.053695e-01 0.094 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.075737e-01 0.093 0 0
Glycosphingolipid transport R-HSA-9845576 8.075737e-01 0.093 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.075737e-01 0.093 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.076279e-01 0.093 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.115132e-01 0.091 0 0
Metal ion SLC transporters R-HSA-425410 8.149654e-01 0.089 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.192296e-01 0.087 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.192296e-01 0.087 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.192296e-01 0.087 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.192296e-01 0.087 0 0
Voltage gated Potassium channels R-HSA-1296072 8.196494e-01 0.086 0 0
Processing of SMDT1 R-HSA-8949664 8.201026e-01 0.086 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.201026e-01 0.086 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.201026e-01 0.086 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.201026e-01 0.086 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.201026e-01 0.086 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.201026e-01 0.086 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.201026e-01 0.086 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.201026e-01 0.086 0 0
Aquaporin-mediated transport R-HSA-445717 8.237971e-01 0.084 1 0
FCERI mediated NF-kB activation R-HSA-2871837 8.296107e-01 0.081 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.326003e-01 0.080 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.326003e-01 0.080 0 0
Sphingolipid catabolism R-HSA-9845614 8.326003e-01 0.080 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.326003e-01 0.080 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.353315e-01 0.078 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.358922e-01 0.078 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.373784e-01 0.077 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.373784e-01 0.077 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.373784e-01 0.077 0 0
Hydrolysis of LPC R-HSA-1483115 8.373784e-01 0.077 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.373784e-01 0.077 0 0
Prolactin receptor signaling R-HSA-1170546 8.373784e-01 0.077 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.373784e-01 0.077 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.373784e-01 0.077 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.373784e-01 0.077 0 0
Viral Infection Pathways R-HSA-9824446 8.391803e-01 0.076 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.417387e-01 0.075 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.417387e-01 0.075 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.419209e-01 0.075 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.450712e-01 0.073 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.450712e-01 0.073 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.468698e-01 0.072 1 0
Toll-like Receptor Cascades R-HSA-168898 8.478328e-01 0.072 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.520635e-01 0.070 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.529961e-01 0.069 0 0
Biotin transport and metabolism R-HSA-196780 8.529961e-01 0.069 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.529961e-01 0.069 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.537884e-01 0.069 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.537884e-01 0.069 0 0
Telomere Extension By Telomerase R-HSA-171319 8.566917e-01 0.067 0 0
Inflammasomes R-HSA-622312 8.566917e-01 0.067 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.608365e-01 0.065 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.608365e-01 0.065 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.616788e-01 0.065 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.623385e-01 0.064 0 0
ER-Phagosome pathway R-HSA-1236974 8.631134e-01 0.064 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.671147e-01 0.062 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.671147e-01 0.062 0 0
Differentiation of T cells R-HSA-9945266 8.671147e-01 0.062 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.671147e-01 0.062 0 0
Fructose catabolism R-HSA-70350 8.671147e-01 0.062 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.671147e-01 0.062 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.671147e-01 0.062 0 0
Attachment and Entry R-HSA-9678110 8.671147e-01 0.062 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.675102e-01 0.062 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.675102e-01 0.062 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.675102e-01 0.062 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.705658e-01 0.060 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.707406e-01 0.060 0 0
HIV Transcription Initiation R-HSA-167161 8.707406e-01 0.060 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.707406e-01 0.060 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.707406e-01 0.060 0 0
Kidney development R-HSA-9830369 8.731100e-01 0.059 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.774871e-01 0.057 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.774871e-01 0.057 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.775735e-01 0.057 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.775735e-01 0.057 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.792734e-01 0.056 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.798781e-01 0.056 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.798781e-01 0.056 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.798781e-01 0.056 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.798781e-01 0.056 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.798781e-01 0.056 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.798781e-01 0.056 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.798781e-01 0.056 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.798781e-01 0.056 0 0
Coenzyme A biosynthesis R-HSA-196783 8.798781e-01 0.056 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.798781e-01 0.056 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.798781e-01 0.056 0 0
Metabolism of amine-derived hormones R-HSA-209776 8.854617e-01 0.053 0 0
Neddylation R-HSA-8951664 8.856064e-01 0.053 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.869268e-01 0.052 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.869268e-01 0.052 0 0
Downstream signal transduction R-HSA-186763 8.869268e-01 0.052 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.873015e-01 0.052 0 0
PPARA activates gene expression R-HSA-1989781 8.873383e-01 0.052 0 0
Signaling by Insulin receptor R-HSA-74752 8.876921e-01 0.052 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.914163e-01 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.914163e-01 0.050 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.914163e-01 0.050 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.914163e-01 0.050 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.914163e-01 0.050 0 0
Catecholamine biosynthesis R-HSA-209905 8.914163e-01 0.050 0 0
Choline catabolism R-HSA-6798163 8.914163e-01 0.050 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.914163e-01 0.050 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.932236e-01 0.049 0 0
Cellular response to chemical stress R-HSA-9711123 8.932408e-01 0.049 0 0
Surfactant metabolism R-HSA-5683826 8.948488e-01 0.048 0 0
Amine ligand-binding receptors R-HSA-375280 8.948488e-01 0.048 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.953292e-01 0.048 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.959106e-01 0.048 0 0
Immune System R-HSA-168256 8.963681e-01 0.048 1 0
Leishmania infection R-HSA-9658195 8.991551e-01 0.046 1 0
Parasitic Infection Pathways R-HSA-9824443 8.991551e-01 0.046 1 0
Cellular response to starvation R-HSA-9711097 8.999927e-01 0.046 0 0
Neutrophil degranulation R-HSA-6798695 9.013927e-01 0.045 0 0
Interferon alpha/beta signaling R-HSA-909733 9.016029e-01 0.045 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.018468e-01 0.045 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.018468e-01 0.045 0 0
Mismatch Repair R-HSA-5358508 9.018468e-01 0.045 0 0
Tie2 Signaling R-HSA-210993 9.018468e-01 0.045 0 0
Nephron development R-HSA-9831926 9.018468e-01 0.045 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.018468e-01 0.045 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.019386e-01 0.045 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.019386e-01 0.045 1 1
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.036756e-01 0.044 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.047581e-01 0.043 0 0
Peroxisomal protein import R-HSA-9033241 9.051218e-01 0.043 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.085938e-01 0.042 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.085938e-01 0.042 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.101901e-01 0.041 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.111526e-01 0.040 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.111526e-01 0.040 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.111526e-01 0.040 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.111526e-01 0.040 1 0
Germ layer formation at gastrulation R-HSA-9754189 9.112759e-01 0.040 0 0
Pyrimidine biosynthesis R-HSA-500753 9.112759e-01 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.112759e-01 0.040 0 0
Other interleukin signaling R-HSA-449836 9.112759e-01 0.040 0 0
Diseases of hemostasis R-HSA-9671793 9.112759e-01 0.040 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.112759e-01 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.112759e-01 0.040 0 0
Potassium Channels R-HSA-1296071 9.130998e-01 0.039 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.148368e-01 0.039 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.156578e-01 0.038 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.180826e-01 0.037 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.197997e-01 0.036 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.197997e-01 0.036 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.197997e-01 0.036 0 0
Creatine metabolism R-HSA-71288 9.197997e-01 0.036 0 0
Pregnenolone biosynthesis R-HSA-196108 9.197997e-01 0.036 0 0
Signaling by NODAL R-HSA-1181150 9.197997e-01 0.036 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.206889e-01 0.036 0 0
Selenoamino acid metabolism R-HSA-2408522 9.218039e-01 0.035 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.245018e-01 0.034 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.245018e-01 0.034 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.245018e-01 0.034 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.245018e-01 0.034 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.269657e-01 0.033 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.275051e-01 0.033 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.275051e-01 0.033 0 0
Triglyceride catabolism R-HSA-163560 9.304441e-01 0.031 1 1
RUNX2 regulates bone development R-HSA-8941326 9.304441e-01 0.031 0 0
Neurotransmitter release cycle R-HSA-112310 9.328994e-01 0.030 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.344706e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.344706e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.344706e-01 0.029 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.344706e-01 0.029 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.359420e-01 0.029 0 0
Phospholipid metabolism R-HSA-1483257 9.360186e-01 0.029 0 0
Formation of the cornified envelope R-HSA-6809371 9.361860e-01 0.029 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.407672e-01 0.027 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.407672e-01 0.027 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.407672e-01 0.027 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.407672e-01 0.027 0 0
Fructose metabolism R-HSA-5652084 9.407672e-01 0.027 0 0
Ethanol oxidation R-HSA-71384 9.407672e-01 0.027 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.407672e-01 0.027 0 0
Elastic fibre formation R-HSA-1566948 9.410260e-01 0.026 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.410260e-01 0.026 0 0
Integration of energy metabolism R-HSA-163685 9.437692e-01 0.025 1 0
G alpha (s) signalling events R-HSA-418555 9.445312e-01 0.025 1 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.446818e-01 0.025 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.450851e-01 0.025 1 1
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.457249e-01 0.024 0 0
Transmission across Chemical Synapses R-HSA-112315 9.462139e-01 0.024 1 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.464591e-01 0.024 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.464591e-01 0.024 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.464591e-01 0.024 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.464591e-01 0.024 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.464591e-01 0.024 0 0
Biosynthesis of maresins R-HSA-9018682 9.464591e-01 0.024 0 0
Formation of the ureteric bud R-HSA-9830674 9.464591e-01 0.024 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.464591e-01 0.024 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.464591e-01 0.024 0 0
Carnitine shuttle R-HSA-200425 9.464591e-01 0.024 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.464591e-01 0.024 0 0
Interleukin-20 family signaling R-HSA-8854691 9.464591e-01 0.024 0 0
rRNA processing R-HSA-72312 9.496465e-01 0.022 0 0
Diseases of Immune System R-HSA-5260271 9.500656e-01 0.022 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.500656e-01 0.022 0 0
CYP2E1 reactions R-HSA-211999 9.516043e-01 0.022 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.516043e-01 0.022 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.516043e-01 0.022 0 0
Complex III assembly R-HSA-9865881 9.516043e-01 0.022 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.516043e-01 0.022 0 0
Maturation of spike protein R-HSA-9694548 9.540737e-01 0.020 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.555743e-01 0.020 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.557844e-01 0.020 0 0
Hemostasis R-HSA-109582 9.560154e-01 0.020 1 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.562554e-01 0.019 0 0
G protein gated Potassium channels R-HSA-1296059 9.562554e-01 0.019 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.562554e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.562554e-01 0.019 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.562554e-01 0.019 0 0
Hyaluronan degradation R-HSA-2160916 9.562554e-01 0.019 0 0
Laminin interactions R-HSA-3000157 9.562554e-01 0.019 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.570274e-01 0.019 0 0
MET activates PTK2 signaling R-HSA-8874081 9.604597e-01 0.018 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.604597e-01 0.018 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.604597e-01 0.018 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.621418e-01 0.017 0 0
Regulation of insulin secretion R-HSA-422356 9.627730e-01 0.016 1 1
EPHA-mediated growth cone collapse R-HSA-3928663 9.642602e-01 0.016 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.642602e-01 0.016 0 0
Triglyceride biosynthesis R-HSA-75109 9.642602e-01 0.016 0 0
Synthesis of PE R-HSA-1483213 9.642602e-01 0.016 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.642602e-01 0.016 0 0
Insulin processing R-HSA-264876 9.642602e-01 0.016 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.642602e-01 0.016 0 0
Triglyceride metabolism R-HSA-8979227 9.647004e-01 0.016 1 0
Regulation of beta-cell development R-HSA-186712 9.647004e-01 0.016 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.647004e-01 0.016 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.660335e-01 0.015 0 0
Proteasome assembly R-HSA-9907900 9.672335e-01 0.014 0 0
tRNA Aminoacylation R-HSA-379724 9.672751e-01 0.014 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.672751e-01 0.014 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.673937e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.676956e-01 0.014 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.676956e-01 0.014 0 0
Insulin receptor recycling R-HSA-77387 9.676956e-01 0.014 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.676956e-01 0.014 0 0
Somitogenesis R-HSA-9824272 9.699065e-01 0.013 0 0
Thyroxine biosynthesis R-HSA-209968 9.708009e-01 0.013 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.708009e-01 0.013 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.708009e-01 0.013 0 0
Glucagon-type ligand receptors R-HSA-420092 9.708009e-01 0.013 0 0
Mitochondrial protein import R-HSA-1268020 9.719016e-01 0.012 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.719016e-01 0.012 0 0
Signaling by PDGF R-HSA-186797 9.719016e-01 0.012 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.723686e-01 0.012 0 0
Cholesterol biosynthesis R-HSA-191273 9.735834e-01 0.012 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.736079e-01 0.012 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.736079e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.736079e-01 0.012 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.736079e-01 0.012 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.753890e-01 0.011 0 0
Ion transport by P-type ATPases R-HSA-936837 9.759035e-01 0.011 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.761453e-01 0.010 0 0
Cargo concentration in the ER R-HSA-5694530 9.761453e-01 0.010 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.761453e-01 0.010 0 0
GPER1 signaling R-HSA-9634597 9.767224e-01 0.010 1 1
Gluconeogenesis R-HSA-70263 9.767224e-01 0.010 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.784388e-01 0.009 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.784388e-01 0.009 0 0
HS-GAG degradation R-HSA-2024096 9.784388e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.786425e-01 0.009 0 0
Platelet homeostasis R-HSA-418346 9.786929e-01 0.009 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.805119e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.805119e-01 0.009 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.805119e-01 0.009 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.815140e-01 0.008 0 0
Complex IV assembly R-HSA-9864848 9.820328e-01 0.008 0 0
The phototransduction cascade R-HSA-2514856 9.820328e-01 0.008 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.823858e-01 0.008 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.823858e-01 0.008 0 0
tRNA processing R-HSA-72306 9.827323e-01 0.008 0 0
Extracellular matrix organization R-HSA-1474244 9.831223e-01 0.007 0 0
Interferon gamma signaling R-HSA-877300 9.837618e-01 0.007 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.840796e-01 0.007 0 0
eNOS activation R-HSA-203615 9.840796e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.840796e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.840796e-01 0.007 0 0
Gap junction assembly R-HSA-190861 9.840796e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.848981e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.856106e-01 0.006 0 0
ECM proteoglycans R-HSA-3000178 9.860504e-01 0.006 0 0
HS-GAG biosynthesis R-HSA-2022928 9.869945e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.869945e-01 0.006 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.882454e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.882454e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.882454e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.882454e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.882454e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.893565e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.893760e-01 0.005 0 0
Purine salvage R-HSA-74217 9.893760e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.893760e-01 0.005 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.895562e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.896033e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.903979e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.903979e-01 0.004 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.910747e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.913216e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.918290e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.918290e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.918290e-01 0.004 0 0
Integrin cell surface interactions R-HSA-216083 9.920231e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.921565e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.925208e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.925208e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.929111e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.929201e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.935931e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.935931e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.935931e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.937368e-01 0.003 0 0
Pyrimidine catabolism R-HSA-73621 9.942096e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.942699e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.943592e-01 0.002 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.943592e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.947668e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.952060e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.952704e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.956161e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.956161e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.959916e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.961369e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.964746e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.966504e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.969386e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.970275e-01 0.001 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.970275e-01 0.001 1 0
Azathioprine ADME R-HSA-9748787 9.971485e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.971525e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.972024e-01 0.001 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.974702e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.976749e-01 0.001 0 0
Gastrulation R-HSA-9758941 9.977923e-01 0.001 0 0
Protein folding R-HSA-391251 9.978592e-01 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.978953e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.980311e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.981895e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.982811e-01 0.001 0 0
Protein localization R-HSA-9609507 9.983223e-01 0.001 0 0
Digestion R-HSA-8935690 9.984466e-01 0.001 0 0
Scavenging of heme from plasma R-HSA-2168880 9.984699e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.987635e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.988125e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.988536e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.989640e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.990638e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.990638e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.992355e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993091e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.993679e-01 0.000 1 0
Translation R-HSA-72766 9.993855e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.993933e-01 0.000 1 0
Classical antibody-mediated complement activation R-HSA-173623 9.994060e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994902e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.994902e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.995825e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996601e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996601e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996821e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996928e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.997225e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997470e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997492e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.997595e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998169e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998215e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998521e-01 0.000 1 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998767e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998982e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999116e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999156e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999436e-01 0.000 1 0
Infectious disease R-HSA-5663205 9.999457e-01 0.000 1 0
Visual phototransduction R-HSA-2187338 9.999483e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999500e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999553e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999561e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999565e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999638e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999810e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999854e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999896e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999935e-01 0.000 1 0
Sensory perception of taste R-HSA-9717189 9.999946e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999954e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999957e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999961e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999965e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999967e-01 0.000 0 0
Disease R-HSA-1643685 9.999969e-01 0.000 1 0
Sphingolipid metabolism R-HSA-428157 9.999975e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999979e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999984e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999991e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999993e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999994e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999995e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999997e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 1 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways