CAMK1D

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15212 T38 Sugiyama PFDN6 HKE2 PFD6 QLQKDLSKSMSGRQKLEAQLtENNIVKEELALLDGsNVVFK
O15226 S618 Sugiyama NKRF ITBA4 NRF VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O94776 T621 Sugiyama MTA2 MTA1L1 PID APNPVVFVATKDTRALRKALtHLEMRRAARRPNLPLKVKPT
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S15 Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07900 S468 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25705 S65 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30040 T62 Sugiyama ERP29 C12orf8 ERP28 DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P40818 S718 Sugiyama USP8 KIAA0055 UBPY AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 T1764 Sugiyama MKI67 LVDtPtssKPQPKRSLRKADtEEEFLAFRKQTPSAGKAMHt
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P50454 S139 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454 S141 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50750 T186 GPS6 CDK9 CDC2L4 TAK ADFGLARAFsLAKNSQPNRytNRVVTLWYRPPELLLGERDY
P52272 S618 Sugiyama HNRNPM HNRPM NAGR1 PALGAGIERMGLAMGGGGGAsFDRAIEMERGNFGGsFAGsF
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09472 S89 ELM EP300 P300 GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q13085 S25 ELM ACACA ACAC ACC1 ACCA sPLAQPLELNQHSRFIIGsVsEDNsEDEISNLVKLDLLEEK
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13625 S480 Sugiyama TP53BP2 ASPP2 BBP FDAVDQSNAPPSFGTLRKNQssEDILRDAQVANKNVAKVPP
Q14012 T177 ELM CAMK1 KIMISDFGLSKMEDPGSVLstACGTPGYVAPEVLAQKPYSK
Q14012 T310 Sugiyama CAMK1 VSEQIKKNFAKSKWKQAFNAtAVVRHMRKLQLGtsQEGQGQ
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q5JTD0 S545 Sugiyama TJAP1 PILT TJP4 ssRPQRsPKRMGVHHLHRKDsLtQAQEQGNLLN________
Q5UIP0 S1688 Sugiyama RIF1 PVPESNLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssL
Q5VT52 S1068 Sugiyama RPRD2 KIAA0460 HSPC099 SLTATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETL
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86W56 S286 Sugiyama PARG VGSEDVGTGPKNDNKLTRQEsCLGNsPPFEKESEPEsPMDV
Q8IU85 S154 Sugiyama CAMK1D CAMKID YLHRMGIVHRDLKPENLLYYsQDEEsKIMISDFGLSKMEGK
Q8IU85 S159 Sugiyama CAMK1D CAMKID GIVHRDLKPENLLYYsQDEEsKIMISDFGLSKMEGKGDVMs
Q8IU85 S64 Sugiyama CAMK1D CAMKID ATGKLFAVKCIPKKALKGKEssIENEIAVLRKIKHENIVAL
Q8IU85 S65 Sugiyama CAMK1D CAMKID TGKLFAVKCIPKKALKGKEssIENEIAVLRKIKHENIVALE
Q8IU85 T313 Sugiyama CAMK1D CAMKID VSAQIRKNFAKSKWRQAFNAtAVVRHMRKLHLGssLDssNA
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NDV7 S1209 Sugiyama TNRC6A CAGH26 KIAA1460 TNRC6 MMKGGNKQEEAWINPFVKQFsNIsFsRDsPEENVQSNKMDL
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q9BQ16 T118 Sugiyama SPOCK3 TICN3 UNQ409/PRO771 HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9P1Y5 S431 Sugiyama CAMSAP3 KIAA1543 FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2 T1204 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UPR0 T584 Sugiyama PLCL2 KIAA1092 PLCE2 KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 2.560669e-10 9.592 0 0
Attenuation phase R-HSA-3371568 6.738754e-08 7.171 0 0
Chromatin modifying enzymes R-HSA-3247509 5.850276e-07 6.233 0 0
NRAGE signals death through JNK R-HSA-193648 7.177533e-07 6.144 0 0
Chromatin organization R-HSA-4839726 2.347446e-06 5.629 0 0
Signal Transduction R-HSA-162582 2.987703e-06 5.525 0 0
Cellular response to heat stress R-HSA-3371556 3.657249e-06 5.437 0 0
HSF1 activation R-HSA-3371511 7.710719e-06 5.113 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.867276e-06 5.052 0 0
G alpha (12/13) signalling events R-HSA-416482 1.110486e-05 4.954 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.688927e-05 4.772 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.156839e-05 4.666 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.666334e-05 4.331 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.881527e-05 4.311 0 0
Death Receptor Signaling R-HSA-73887 7.377940e-05 4.132 0 0
Cell Cycle R-HSA-1640170 1.037487e-04 3.984 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.127250e-04 3.948 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.298771e-04 3.886 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.481471e-04 3.829 0 0
Regulation of TP53 Activity R-HSA-5633007 1.622655e-04 3.790 0 0
Apoptotic execution phase R-HSA-75153 1.863405e-04 3.730 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.869779e-04 3.542 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.869779e-04 3.542 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.967296e-04 3.528 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.018747e-04 3.299 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.365539e-04 3.196 0 0
Cell Cycle, Mitotic R-HSA-69278 6.238801e-04 3.205 0 0
Activation of RAC1 R-HSA-428540 7.276399e-04 3.138 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.775467e-04 3.057 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.101601e-03 2.958 0 0
Cell Cycle Checkpoints R-HSA-69620 1.225333e-03 2.912 0 0
Axon guidance R-HSA-422475 1.298076e-03 2.887 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.413609e-03 2.850 0 0
Mitotic Prometaphase R-HSA-68877 1.362736e-03 2.866 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.413609e-03 2.850 0 0
Nervous system development R-HSA-9675108 1.586536e-03 2.800 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.731338e-03 2.762 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.713075e-03 2.766 0 0
RNA Polymerase II Transcription R-HSA-73857 2.014819e-03 2.696 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.095893e-03 2.679 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.120969e-03 2.673 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.453496e-03 2.610 0 0
Gene expression (Transcription) R-HSA-74160 2.383525e-03 2.623 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.745371e-03 2.561 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.745371e-03 2.561 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.745371e-03 2.561 0 0
Signaling by RAS mutants R-HSA-6802949 2.745371e-03 2.561 0 0
Cellular Senescence R-HSA-2559583 2.779563e-03 2.556 0 0
HATs acetylate histones R-HSA-3214847 3.091954e-03 2.510 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.062654e-03 2.514 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.191688e-03 2.496 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.200352e-03 2.495 0 0
Signaling by VEGF R-HSA-194138 3.322855e-03 2.478 0 0
Ion homeostasis R-HSA-5578775 3.401177e-03 2.468 0 0
Rab regulation of trafficking R-HSA-9007101 3.683479e-03 2.434 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.598779e-03 2.444 0 0
Calmodulin induced events R-HSA-111933 3.945586e-03 2.404 0 0
CaM pathway R-HSA-111997 3.945586e-03 2.404 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.178779e-03 2.379 0 0
Long-term potentiation R-HSA-9620244 4.252417e-03 2.371 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.910496e-03 2.309 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.910496e-03 2.309 0 0
Striated Muscle Contraction R-HSA-390522 5.089511e-03 2.293 0 0
The NLRP3 inflammasome R-HSA-844456 5.282829e-03 2.277 0 0
DAG and IP3 signaling R-HSA-1489509 5.121226e-03 2.291 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.555988e-03 2.255 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.021561e-03 2.220 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.788489e-03 2.168 0 0
Generic Transcription Pathway R-HSA-212436 6.547187e-03 2.184 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.076159e-03 2.150 0 0
Centrosome maturation R-HSA-380287 7.305404e-03 2.136 0 0
G2/M Transition R-HSA-69275 7.432822e-03 2.129 0 0
Neurexins and neuroligins R-HSA-6794361 7.795340e-03 2.108 0 0
Cell-Cell communication R-HSA-1500931 8.074507e-03 2.093 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.092124e-03 2.092 0 0
Signaling by ROBO receptors R-HSA-376176 8.099942e-03 2.092 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.400895e-03 2.076 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.754014e-03 2.058 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.667574e-03 2.062 0 0
Signaling by Hippo R-HSA-2028269 8.832033e-03 2.054 0 0
Specification of primordial germ cells R-HSA-9827857 8.832033e-03 2.054 0 0
RET signaling R-HSA-8853659 9.211533e-03 2.036 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.872815e-03 2.006 0 0
mRNA Splicing R-HSA-72172 9.446629e-03 2.025 0 0
DARPP-32 events R-HSA-180024 1.049346e-02 1.979 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.105573e-02 1.956 0 0
HDMs demethylate histones R-HSA-3214842 1.102675e-02 1.958 0 0
Post NMDA receptor activation events R-HSA-438064 1.098714e-02 1.959 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.121620e-02 1.950 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.091967e-02 1.962 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.151722e-02 1.939 0 0
Cell junction organization R-HSA-446728 1.186530e-02 1.926 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.206095e-02 1.919 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.226883e-02 1.911 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.449270e-02 1.839 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.416396e-02 1.849 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.416396e-02 1.849 0 0
RAF activation R-HSA-5673000 1.433892e-02 1.843 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.377997e-02 1.861 0 0
TRP channels R-HSA-3295583 1.363780e-02 1.865 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.437780e-02 1.842 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.437780e-02 1.842 0 0
Ca-dependent events R-HSA-111996 1.420098e-02 1.848 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.539042e-02 1.813 0 0
Trafficking of AMPA receptors R-HSA-399719 1.552452e-02 1.809 0 0
mRNA 3'-end processing R-HSA-72187 1.571234e-02 1.804 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.571234e-02 1.804 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.491422e-02 1.826 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.570939e-02 1.804 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.559800e-02 1.807 0 0
Programmed Cell Death R-HSA-5357801 1.510206e-02 1.821 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.493993e-02 1.826 0 0
Signaling by ALK in cancer R-HSA-9700206 1.493993e-02 1.826 0 0
Cellular responses to stimuli R-HSA-8953897 1.639909e-02 1.785 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.744334e-02 1.758 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.774492e-02 1.751 0 0
Co-stimulation by CD28 R-HSA-389356 1.744334e-02 1.758 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.669117e-02 1.778 0 0
TBC/RABGAPs R-HSA-8854214 1.662379e-02 1.779 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.670216e-02 1.777 0 0
NGF-stimulated transcription R-HSA-9031628 1.744334e-02 1.758 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.724614e-02 1.763 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.808273e-02 1.743 0 0
G0 and Early G1 R-HSA-1538133 1.863818e-02 1.730 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.865330e-02 1.729 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.891444e-02 1.723 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.891444e-02 1.723 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.900160e-02 1.721 0 0
Netrin-1 signaling R-HSA-373752 1.935168e-02 1.713 0 0
M Phase R-HSA-68886 2.043154e-02 1.690 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.179259e-02 1.662 0 0
Neurodegenerative Diseases R-HSA-8863678 2.179259e-02 1.662 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.219651e-02 1.654 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.219651e-02 1.654 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.306775e-02 1.637 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.315091e-02 1.635 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.340475e-02 1.631 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.566261e-02 1.591 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.566261e-02 1.591 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.566261e-02 1.591 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.566261e-02 1.591 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.528130e-02 1.597 0 0
Kinesins R-HSA-983189 2.398239e-02 1.620 0 0
Muscle contraction R-HSA-397014 2.426275e-02 1.615 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.528130e-02 1.597 0 0
MAPK family signaling cascades R-HSA-5683057 2.479309e-02 1.606 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.425679e-02 1.615 0 0
NrCAM interactions R-HSA-447038 2.528130e-02 1.597 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.592215e-02 1.586 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.623293e-02 1.581 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.719916e-02 1.565 0 0
Polo-like kinase mediated events R-HSA-156711 3.047639e-02 1.516 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.891206e-02 1.539 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.771345e-02 1.557 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.047639e-02 1.516 0 0
Apoptosis R-HSA-109581 2.935213e-02 1.532 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.855261e-02 1.544 0 0
Type I hemidesmosome assembly R-HSA-446107 3.081152e-02 1.511 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.081152e-02 1.511 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.081152e-02 1.511 0 0
Metalloprotease DUBs R-HSA-5689901 3.174911e-02 1.498 0 0
DCC mediated attractive signaling R-HSA-418885 3.192260e-02 1.496 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.236682e-02 1.490 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.236682e-02 1.490 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.427322e-02 1.465 0 0
Diseases of programmed cell death R-HSA-9645723 3.571113e-02 1.447 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.776966e-02 1.423 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.787075e-02 1.422 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.751512e-02 1.426 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.776966e-02 1.423 0 0
RMTs methylate histone arginines R-HSA-3214858 3.787075e-02 1.422 0 0
Rap1 signalling R-HSA-392517 3.756913e-02 1.425 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.616399e-02 1.442 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.827049e-02 1.417 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.827049e-02 1.417 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.827049e-02 1.417 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.827049e-02 1.417 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.827049e-02 1.417 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.829913e-02 1.417 0 0
Cellular responses to stress R-HSA-2262752 3.848924e-02 1.415 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.977046e-02 1.400 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.977046e-02 1.400 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.977046e-02 1.400 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.977046e-02 1.400 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.977046e-02 1.400 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.206980e-02 1.376 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.199818e-02 1.377 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.152161e-02 1.382 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.477755e-02 1.349 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.017115e-02 1.396 0 0
Cardiac conduction R-HSA-5576891 4.240151e-02 1.373 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.447823e-02 1.352 0 0
FLT3 Signaling R-HSA-9607240 4.251906e-02 1.371 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.206980e-02 1.376 0 0
Inflammasomes R-HSA-622312 4.453533e-02 1.351 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.017115e-02 1.396 0 0
Nephrin family interactions R-HSA-373753 4.569166e-02 1.340 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.650344e-02 1.333 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.777039e-02 1.321 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.805244e-02 1.318 0 0
PLC beta mediated events R-HSA-112043 4.805244e-02 1.318 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.851993e-02 1.314 0 0
Separation of Sister Chromatids R-HSA-2467813 4.877305e-02 1.312 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.951290e-02 1.305 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.155492e-02 1.288 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.155492e-02 1.288 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.325961e-02 1.274 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.325961e-02 1.274 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.341184e-02 1.272 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.341184e-02 1.272 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.488565e-02 1.261 0 0
MTOR signalling R-HSA-165159 5.503140e-02 1.259 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.714083e-02 1.243 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.753290e-02 1.240 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.213424e-02 1.207 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.169028e-02 1.210 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.639314e-02 1.178 0 0
Membrane Trafficking R-HSA-199991 5.822609e-02 1.235 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.539612e-02 1.184 0 0
Semaphorin interactions R-HSA-373755 5.917499e-02 1.228 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.919583e-02 1.160 0 0
MTF1 activates gene expression R-HSA-5660489 6.919583e-02 1.160 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.919583e-02 1.160 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.919583e-02 1.160 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.919583e-02 1.160 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.919583e-02 1.160 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.013357e-02 1.154 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.019564e-02 1.154 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.115130e-02 1.148 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.227045e-02 1.141 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.247290e-02 1.140 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.272320e-02 1.138 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.272320e-02 1.138 0 0
PKA activation R-HSA-163615 7.272320e-02 1.138 0 0
PKA activation in glucagon signalling R-HSA-164378 7.272320e-02 1.138 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.374572e-02 1.132 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.091475e-02 1.092 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 8.091475e-02 1.092 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 8.091475e-02 1.092 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.078742e-02 1.093 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.078742e-02 1.093 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.625295e-02 1.064 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.659508e-02 1.116 0 0
HDACs deacetylate histones R-HSA-3214815 7.535029e-02 1.123 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.872050e-02 1.104 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.909367e-02 1.102 0 0
p75NTR signals via NF-kB R-HSA-193639 8.078742e-02 1.093 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.421561e-02 1.130 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.872050e-02 1.104 0 0
G-protein mediated events R-HSA-112040 8.645194e-02 1.063 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.436296e-02 1.129 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.812127e-02 1.107 0 0
Cell-cell junction organization R-HSA-421270 8.156853e-02 1.088 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.625295e-02 1.064 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.078742e-02 1.093 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.857239e-02 1.053 0 0
MAP2K and MAPK activation R-HSA-5674135 8.857239e-02 1.053 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.857239e-02 1.053 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.895628e-02 1.051 0 0
Heme signaling R-HSA-9707616 8.905129e-02 1.050 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.913295e-02 1.050 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.043308e-02 1.044 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.043308e-02 1.044 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.043308e-02 1.044 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.132418e-02 1.039 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.162261e-02 1.038 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.176231e-02 1.037 0 0
Co-stimulation by ICOS R-HSA-9927354 9.604175e-02 1.018 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.703699e-02 1.013 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 9.703699e-02 1.013 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 9.836774e-02 1.007 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 9.836774e-02 1.007 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 9.836774e-02 1.007 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 9.836774e-02 1.007 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.836774e-02 1.007 0 0
G2 Phase R-HSA-68911 9.836774e-02 1.007 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.088427e-01 0.963 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.088427e-01 0.963 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.088427e-01 0.963 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.088427e-01 0.963 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.088427e-01 0.963 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.011145e-01 0.995 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.011145e-01 0.995 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.011145e-01 0.995 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.011145e-01 0.995 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.011145e-01 0.995 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.029444e-01 0.987 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.146343e-01 0.941 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.122529e-01 0.950 0 0
Meiotic synapsis R-HSA-1221632 1.036069e-01 0.985 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.115082e-01 0.953 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.115082e-01 0.953 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.098180e-01 0.959 0 0
Opioid Signalling R-HSA-111885 9.924550e-02 1.003 0 0
Signaling by SCF-KIT R-HSA-1433557 1.095430e-01 0.960 0 0
Deubiquitination R-HSA-5688426 9.768993e-02 1.010 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.107883e-01 0.956 0 0
Mitotic Anaphase R-HSA-68882 1.058126e-01 0.975 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.775066e-02 1.010 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.066321e-01 0.972 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.029444e-01 0.987 0 0
Signaling by Interleukins R-HSA-449147 1.031830e-01 0.986 0 0
Interleukin-37 signaling R-HSA-9008059 1.164953e-01 0.934 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.172765e-01 0.931 0 0
Tight junction interactions R-HSA-420029 1.175372e-01 0.930 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.175372e-01 0.930 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.447070e-01 0.840 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.447070e-01 0.840 0 0
DSCAM interactions R-HSA-376172 1.302599e-01 0.885 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.302599e-01 0.885 0 0
Potassium transport channels R-HSA-1296067 1.302599e-01 0.885 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.684809e-01 0.571 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.684809e-01 0.571 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.684809e-01 0.571 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.684809e-01 0.571 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.684809e-01 0.571 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.684809e-01 0.571 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.684809e-01 0.571 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.684809e-01 0.571 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.684809e-01 0.571 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.684809e-01 0.571 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.315914e-01 0.881 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.315914e-01 0.881 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.315914e-01 0.881 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.315914e-01 0.881 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.315914e-01 0.881 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.210975e-01 0.917 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.210975e-01 0.917 0 0
Calcineurin activates NFAT R-HSA-2025928 1.210975e-01 0.917 0 0
CREB phosphorylation R-HSA-199920 1.680972e-01 0.774 0 0
NADE modulates death signalling R-HSA-205025 2.413838e-01 0.617 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.413838e-01 0.617 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.413838e-01 0.617 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.413838e-01 0.617 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.413838e-01 0.617 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.413838e-01 0.617 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.413838e-01 0.617 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.413838e-01 0.617 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.413838e-01 0.617 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.743490e-01 0.427 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.743490e-01 0.427 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.743490e-01 0.427 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.743490e-01 0.427 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.743490e-01 0.427 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.743490e-01 0.427 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.743490e-01 0.427 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.743490e-01 0.427 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.743490e-01 0.427 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.743490e-01 0.427 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.743490e-01 0.427 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.743490e-01 0.427 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.743490e-01 0.427 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.743490e-01 0.427 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.743490e-01 0.427 0 0
Intestinal infectious diseases R-HSA-8942233 3.743490e-01 0.427 0 0
Formation of apoptosome R-HSA-111458 1.486215e-01 0.828 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.486215e-01 0.828 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.486215e-01 0.828 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.486215e-01 0.828 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.071068e-01 0.684 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.071068e-01 0.684 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.071068e-01 0.684 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.071068e-01 0.684 0 0
SOS-mediated signalling R-HSA-112412 2.071068e-01 0.684 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.071068e-01 0.684 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.306867e-01 0.884 0 0
PECAM1 interactions R-HSA-210990 1.782803e-01 0.749 0 0
Signaling by APC mutants R-HSA-4839744 1.782803e-01 0.749 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.782803e-01 0.749 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.782803e-01 0.749 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.782803e-01 0.749 0 0
IRS activation R-HSA-74713 2.988334e-01 0.525 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.988334e-01 0.525 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.988334e-01 0.525 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.543305e-01 0.812 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.342596e-01 0.872 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.342596e-01 0.872 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.478729e-01 0.606 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.478729e-01 0.606 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.097165e-01 0.678 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.795900e-01 0.746 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.795900e-01 0.746 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.795900e-01 0.746 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.795900e-01 0.746 0 0
Notch-HLH transcription pathway R-HSA-350054 1.532955e-01 0.814 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.062615e-01 0.686 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.425633e-01 0.615 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.425633e-01 0.615 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.425633e-01 0.615 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.897047e-01 0.538 0 0
Lipophagy R-HSA-9613354 2.897047e-01 0.538 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.897047e-01 0.538 0 0
WNT mediated activation of DVL R-HSA-201688 2.897047e-01 0.538 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.555477e-01 0.449 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.555477e-01 0.449 0 0
Phosphorylation of Emi1 R-HSA-176417 3.555477e-01 0.449 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.555477e-01 0.449 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.555477e-01 0.449 0 0
Signaling by MAPK mutants R-HSA-9652817 3.555477e-01 0.449 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.649006e-01 0.333 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.649006e-01 0.333 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.649006e-01 0.333 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.649006e-01 0.333 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.649006e-01 0.333 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.649006e-01 0.333 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.501891e-01 0.823 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.501891e-01 0.823 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.501891e-01 0.823 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.501891e-01 0.823 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.004792e-01 0.698 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.341287e-01 0.631 0 0
HIV elongation arrest and recovery R-HSA-167287 1.679958e-01 0.775 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.679958e-01 0.775 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.764571e-01 0.558 0 0
Formation of axial mesoderm R-HSA-9796292 2.764571e-01 0.558 0 0
HIV Transcription Elongation R-HSA-167169 1.246031e-01 0.904 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.246031e-01 0.904 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.246031e-01 0.904 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.937589e-01 0.713 0 0
Deadenylation of mRNA R-HSA-429947 1.937589e-01 0.713 0 0
G1/S-Specific Transcription R-HSA-69205 1.421075e-01 0.847 0 0
Integrin signaling R-HSA-354192 1.625802e-01 0.789 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.248248e-01 0.648 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.248248e-01 0.648 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.319828e-01 0.479 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.319828e-01 0.479 0 0
Signaling by Erythropoietin R-HSA-9006335 1.867107e-01 0.729 0 0
Late endosomal microautophagy R-HSA-9615710 1.867107e-01 0.729 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.629691e-01 0.580 0 0
TGFBR3 expression R-HSA-9839394 2.154339e-01 0.667 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.154339e-01 0.667 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.110472e-01 0.507 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.110472e-01 0.507 0 0
cGMP effects R-HSA-418457 3.110472e-01 0.507 0 0
Signaling by LTK in cancer R-HSA-9842640 4.105368e-01 0.387 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.105368e-01 0.387 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.105368e-01 0.387 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.105368e-01 0.387 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.974429e-01 0.705 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.974429e-01 0.705 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.925588e-01 0.534 0 0
Ephrin signaling R-HSA-3928664 2.925588e-01 0.534 0 0
Regulation of CDH1 Function R-HSA-9764561 1.470328e-01 0.833 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.207469e-01 0.918 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.741660e-01 0.427 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.741660e-01 0.427 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.741660e-01 0.427 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.661133e-01 0.780 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.060240e-01 0.686 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.611515e-01 0.583 0 0
Packaging Of Telomere Ends R-HSA-171306 2.611515e-01 0.583 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.349026e-01 0.870 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.226781e-01 0.491 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.026245e-01 0.519 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.849714e-01 0.545 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.210890e-01 0.917 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.092795e-01 0.510 0 0
DNA methylation R-HSA-5334118 3.092795e-01 0.510 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.531147e-01 0.452 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.531147e-01 0.452 0 0
Differentiation of T cells R-HSA-9945266 3.810186e-01 0.419 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.810186e-01 0.419 0 0
Phosphorylation of the APC/C R-HSA-176412 3.810186e-01 0.419 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.157934e-01 0.381 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.157934e-01 0.381 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.157934e-01 0.381 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.157934e-01 0.381 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.631124e-01 0.334 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.631124e-01 0.334 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.631124e-01 0.334 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.631124e-01 0.334 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.631124e-01 0.334 0 0
Disinhibition of SNARE formation R-HSA-114516 4.631124e-01 0.334 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.631124e-01 0.334 0 0
Axonal growth stimulation R-HSA-209563 5.423510e-01 0.266 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.423510e-01 0.266 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.423510e-01 0.266 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.423510e-01 0.266 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.423510e-01 0.266 0 0
Invadopodia formation R-HSA-8941237 5.423510e-01 0.266 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.423510e-01 0.266 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.423510e-01 0.266 0 0
MET activates PTPN11 R-HSA-8865999 5.423510e-01 0.266 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.423510e-01 0.266 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.423510e-01 0.266 0 0
Defective pyroptosis R-HSA-9710421 2.796589e-01 0.553 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.339607e-01 0.476 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.339607e-01 0.476 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.569245e-01 0.447 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.569245e-01 0.447 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.169282e-01 0.499 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.158185e-01 0.381 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.158185e-01 0.381 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.158185e-01 0.381 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.158185e-01 0.381 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.396452e-01 0.620 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.843556e-01 0.415 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.843556e-01 0.415 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.564817e-01 0.341 0 0
Leading Strand Synthesis R-HSA-69109 4.564817e-01 0.341 0 0
Polymerase switching R-HSA-69091 4.564817e-01 0.341 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.204722e-01 0.494 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.597627e-01 0.444 0 0
Transcription of the HIV genome R-HSA-167172 3.055089e-01 0.515 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.599001e-01 0.444 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.117876e-01 0.385 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.117876e-01 0.385 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.501572e-01 0.347 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.501572e-01 0.347 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.501572e-01 0.347 0 0
Regulation by c-FLIP R-HSA-3371378 5.128214e-01 0.290 0 0
Dimerization of procaspase-8 R-HSA-69416 5.128214e-01 0.290 0 0
MET receptor recycling R-HSA-8875656 5.128214e-01 0.290 0 0
Activation of RAS in B cells R-HSA-1169092 5.128214e-01 0.290 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.128214e-01 0.290 0 0
Formation of annular gap junctions R-HSA-196025 5.128214e-01 0.290 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.128214e-01 0.290 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.128214e-01 0.290 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.588493e-01 0.445 0 0
G1/S Transition R-HSA-69206 2.789452e-01 0.554 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.443832e-01 0.352 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.044780e-01 0.516 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.044780e-01 0.516 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.190693e-01 0.496 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.764238e-01 0.424 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.390906e-01 0.357 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.390906e-01 0.357 0 0
Degradation of CDH1 R-HSA-9766229 4.006428e-01 0.397 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.296262e-01 0.367 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.661441e-01 0.331 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.528312e-01 0.344 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.943666e-01 0.404 0 0
Nucleosome assembly R-HSA-774815 4.471272e-01 0.350 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.471272e-01 0.350 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.164104e-01 0.380 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.171554e-01 0.380 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.171554e-01 0.380 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.624081e-01 0.335 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.688069e-01 0.329 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.928377e-01 0.307 0 0
Activation of the pre-replicative complex R-HSA-68962 4.928377e-01 0.307 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.035093e-01 0.298 0 0
Regulation of signaling by CBL R-HSA-912631 5.166276e-01 0.287 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.166276e-01 0.287 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.166276e-01 0.287 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.166276e-01 0.287 0 0
Removal of the Flap Intermediate R-HSA-69166 5.338693e-01 0.273 0 0
ARMS-mediated activation R-HSA-170984 5.593925e-01 0.252 0 0
Gap junction degradation R-HSA-190873 5.593925e-01 0.252 0 0
CASP8 activity is inhibited R-HSA-5218900 5.593925e-01 0.252 0 0
ALK mutants bind TKIs R-HSA-9700645 5.593925e-01 0.252 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.594874e-01 0.338 0 0
EGFR downregulation R-HSA-182971 5.190716e-01 0.285 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.964294e-01 0.304 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.484251e-01 0.261 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.247690e-01 0.280 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.447569e-01 0.264 0 0
Erythropoietin activates RAS R-HSA-9027284 5.701438e-01 0.244 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.701438e-01 0.244 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.701438e-01 0.244 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.427493e-01 0.265 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.532315e-01 0.257 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.604895e-01 0.251 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.698155e-01 0.244 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.790905e-01 0.237 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.740055e-01 0.241 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.869888e-01 0.231 0 0
Orc1 removal from chromatin R-HSA-68949 5.933788e-01 0.227 0 0
Signaling by EGFR R-HSA-177929 5.427708e-01 0.265 0 0
FOXO-mediated transcription R-HSA-9614085 2.074521e-01 0.683 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.638885e-01 0.334 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.638885e-01 0.334 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.661568e-01 0.779 0 0
Hedgehog 'off' state R-HSA-5610787 2.187801e-01 0.660 0 0
Specification of the neural plate border R-HSA-9834899 3.226781e-01 0.491 0 0
Aggrephagy R-HSA-9646399 3.169282e-01 0.499 0 0
G-protein beta:gamma signalling R-HSA-397795 4.091229e-01 0.388 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.726644e-01 0.763 0 0
Formation of definitive endoderm R-HSA-9823730 3.531147e-01 0.452 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.548832e-01 0.594 0 0
ESR-mediated signaling R-HSA-8939211 2.412755e-01 0.617 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.319828e-01 0.479 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.629691e-01 0.580 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.993535e-01 0.302 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.579048e-01 0.446 0 0
Prolonged ERK activation events R-HSA-169893 3.810186e-01 0.419 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.336578e-01 0.363 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.336578e-01 0.363 0 0
EPH-Ephrin signaling R-HSA-2682334 1.831328e-01 0.737 0 0
Signaling by ERBB2 R-HSA-1227986 2.711498e-01 0.567 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.071068e-01 0.684 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.831328e-01 0.737 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.158185e-01 0.381 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.471272e-01 0.350 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.749926e-01 0.323 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.659352e-01 0.780 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.336578e-01 0.363 0 0
Meiosis R-HSA-1500620 2.125924e-01 0.672 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.593925e-01 0.252 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.753125e-01 0.756 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.157934e-01 0.381 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.158185e-01 0.381 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.904090e-01 0.537 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.648211e-01 0.248 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.862459e-01 0.232 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.279714e-01 0.893 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.974429e-01 0.705 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.813522e-01 0.741 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.852669e-01 0.732 0 0
RNA Polymerase I Transcription R-HSA-73864 3.705230e-01 0.431 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.694090e-01 0.328 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.701438e-01 0.244 0 0
Myogenesis R-HSA-525793 5.599974e-01 0.252 0 0
S Phase R-HSA-69242 1.825537e-01 0.739 0 0
Homology Directed Repair R-HSA-5693538 2.559953e-01 0.592 0 0
DNA Double Strand Break Response R-HSA-5693606 5.065797e-01 0.295 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.298227e-01 0.639 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.463465e-01 0.835 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.796293e-01 0.746 0 0
Frs2-mediated activation R-HSA-170968 4.959212e-01 0.305 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.725201e-01 0.429 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.904377e-01 0.309 0 0
TNF signaling R-HSA-75893 2.084076e-01 0.681 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.897047e-01 0.538 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.625802e-01 0.789 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.319828e-01 0.479 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.319828e-01 0.479 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.227419e-01 0.652 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.892799e-01 0.539 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.128214e-01 0.290 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.694090e-01 0.328 0 0
Downstream TCR signaling R-HSA-202424 5.825133e-01 0.235 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.917312e-01 0.717 0 0
Signaling by FGFR4 R-HSA-5654743 5.432867e-01 0.265 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.460227e-01 0.351 0 0
Apoptotic factor-mediated response R-HSA-111471 2.925588e-01 0.534 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.158185e-01 0.381 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.321379e-01 0.274 0 0
Regulation of TP53 Expression R-HSA-6804754 1.302599e-01 0.885 0 0
Regulation of CDH11 function R-HSA-9762292 3.319828e-01 0.479 0 0
PI3K/AKT activation R-HSA-198203 3.319828e-01 0.479 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.726644e-01 0.763 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.631124e-01 0.334 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.536801e-01 0.813 0 0
Cilium Assembly R-HSA-5617833 1.522559e-01 0.817 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.501572e-01 0.347 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.128214e-01 0.290 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.379401e-01 0.471 0 0
Peptide chain elongation R-HSA-156902 3.512392e-01 0.454 0 0
Meiotic recombination R-HSA-912446 4.418779e-01 0.355 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.593925e-01 0.252 0 0
Signaling by FGFR3 R-HSA-5654741 5.862459e-01 0.232 0 0
TCR signaling R-HSA-202403 2.793752e-01 0.554 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.339607e-01 0.476 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.226781e-01 0.491 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.341946e-01 0.362 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.141478e-01 0.383 0 0
Mismatch Repair R-HSA-5358508 2.925588e-01 0.534 0 0
Triglyceride catabolism R-HSA-163560 3.597627e-01 0.444 0 0
Interleukin-1 signaling R-HSA-9020702 4.847746e-01 0.314 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.274424e-01 0.643 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.413838e-01 0.617 0 0
Dopamine receptors R-HSA-390651 2.413838e-01 0.617 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.306867e-01 0.884 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.988334e-01 0.525 0 0
Adrenoceptors R-HSA-390696 2.478729e-01 0.606 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.478729e-01 0.606 0 0
NF-kB is activated and signals survival R-HSA-209560 2.097165e-01 0.678 0 0
mTORC1-mediated signalling R-HSA-166208 1.532955e-01 0.814 0 0
Platelet calcium homeostasis R-HSA-418360 3.092795e-01 0.510 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.383017e-01 0.471 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.564817e-01 0.341 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.564817e-01 0.341 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.128214e-01 0.290 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.081219e-01 0.294 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.701438e-01 0.244 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.605062e-01 0.443 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.605062e-01 0.443 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.514450e-01 0.820 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.462314e-01 0.609 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.395603e-01 0.469 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.434482e-01 0.265 0 0
Signaling by WNT R-HSA-195721 2.878281e-01 0.541 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.198543e-01 0.495 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.685140e-01 0.434 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.091229e-01 0.388 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.599974e-01 0.252 0 0
Ub-specific processing proteases R-HSA-5689880 1.186759e-01 0.926 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.843556e-01 0.415 0 0
Regulated Necrosis R-HSA-5218859 2.167180e-01 0.664 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.680972e-01 0.774 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.478729e-01 0.606 0 0
Signal attenuation R-HSA-74749 3.319828e-01 0.479 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.796293e-01 0.746 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.974429e-01 0.705 0 0
Repression of WNT target genes R-HSA-4641265 4.564817e-01 0.341 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.701438e-01 0.244 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.701438e-01 0.244 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.875538e-01 0.541 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.379346e-01 0.624 0 0
Cyclin D associated events in G1 R-HSA-69231 4.253322e-01 0.371 0 0
G1 Phase R-HSA-69236 4.253322e-01 0.371 0 0
Generation of second messenger molecules R-HSA-202433 4.528312e-01 0.344 0 0
Mitotic Prophase R-HSA-68875 5.245974e-01 0.280 0 0
Autophagy R-HSA-9612973 2.004593e-01 0.698 0 0
Potassium Channels R-HSA-1296071 4.094080e-01 0.388 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.759850e-01 0.322 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.159646e-01 0.666 0 0
Signaling by WNT in cancer R-HSA-4791275 3.839912e-01 0.416 0 0
Selective autophagy R-HSA-9663891 3.512392e-01 0.454 0 0
PTEN Regulation R-HSA-6807070 5.585539e-01 0.253 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.645497e-01 0.438 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.845728e-01 0.734 0 0
Ca2+ activated K+ channels R-HSA-1296052 2.071068e-01 0.684 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.555477e-01 0.449 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.110472e-01 0.507 0 0
Abacavir transmembrane transport R-HSA-2161517 4.105368e-01 0.387 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.691785e-01 0.570 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.605181e-01 0.584 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.157934e-01 0.381 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.836673e-01 0.416 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.158185e-01 0.381 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 5.128214e-01 0.290 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 5.128214e-01 0.290 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.793752e-01 0.554 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.091229e-01 0.388 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.006428e-01 0.397 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.341946e-01 0.362 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.321379e-01 0.274 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.790905e-01 0.237 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.862459e-01 0.232 0 0
Cellular response to chemical stress R-HSA-9711123 5.811851e-01 0.236 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.681666e-01 0.330 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.203181e-01 0.657 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.793752e-01 0.554 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.481461e-01 0.458 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.314405e-01 0.365 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.481461e-01 0.458 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.481461e-01 0.458 0 0
Signaling by FGFR in disease R-HSA-1226099 5.168872e-01 0.287 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.691785e-01 0.570 0 0
UCH proteinases R-HSA-5689603 2.475414e-01 0.606 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.006428e-01 0.397 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.006428e-01 0.397 0 0
Macroautophagy R-HSA-1632852 3.470678e-01 0.460 0 0
Regulation of KIT signaling R-HSA-1433559 1.543305e-01 0.812 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.564817e-01 0.341 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.293593e-01 0.276 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.869991e-01 0.231 0 0
DNA Repair R-HSA-73894 2.092111e-01 0.679 0 0
Neuronal System R-HSA-112316 2.376537e-01 0.624 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.298227e-01 0.639 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.298227e-01 0.639 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.101978e-01 0.387 0 0
Signaling by LTK R-HSA-9842663 2.425633e-01 0.615 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.741660e-01 0.427 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.631124e-01 0.334 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.171554e-01 0.380 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.701438e-01 0.244 0 0
Nuclear RNA decay R-HSA-9930044 5.698155e-01 0.244 0 0
Eukaryotic Translation Termination R-HSA-72764 5.889886e-01 0.230 0 0
Signaling by TGFB family members R-HSA-9006936 2.366519e-01 0.626 0 0
Metabolism of RNA R-HSA-8953854 4.348211e-01 0.362 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.346910e-01 0.871 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.199664e-01 0.658 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.885098e-01 0.311 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.917643e-01 0.535 0 0
Adherens junctions interactions R-HSA-418990 1.492868e-01 0.826 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.097165e-01 0.678 0 0
Neurofascin interactions R-HSA-447043 4.105368e-01 0.387 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.167180e-01 0.664 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.758670e-01 0.323 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.307397e-01 0.275 0 0
Hedgehog 'on' state R-HSA-5632684 5.779605e-01 0.238 0 0
Interleukin-1 family signaling R-HSA-446652 3.434019e-01 0.464 0 0
Cleavage of the damaged purine R-HSA-110331 3.830113e-01 0.417 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.501572e-01 0.347 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.015027e-01 0.521 0 0
mRNA Editing R-HSA-75072 5.593925e-01 0.252 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.866971e-01 0.729 0 0
Reproduction R-HSA-1474165 1.618969e-01 0.791 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.198543e-01 0.495 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.701438e-01 0.244 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.432867e-01 0.265 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.452270e-01 0.610 0 0
G2/M Checkpoints R-HSA-69481 3.781936e-01 0.422 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.035093e-01 0.298 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.032734e-01 0.394 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.174116e-01 0.379 0 0
Sensory processing of sound R-HSA-9659379 2.912181e-01 0.536 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.369982e-01 0.360 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.443832e-01 0.352 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.661441e-01 0.331 0 0
MAP kinase activation R-HSA-450294 5.144303e-01 0.289 0 0
Depurination R-HSA-73927 4.063267e-01 0.391 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.259509e-01 0.900 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.555209e-01 0.449 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.520138e-01 0.258 0 0
Signaling by PTK6 R-HSA-8848021 5.520138e-01 0.258 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.684809e-01 0.571 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.743490e-01 0.427 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.486215e-01 0.828 0 0
Regulation of PTEN localization R-HSA-8948747 2.071068e-01 0.684 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.988334e-01 0.525 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.478729e-01 0.606 0 0
Signaling by AXIN mutants R-HSA-4839735 2.097165e-01 0.678 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.097165e-01 0.678 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.550618e-01 0.809 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.062615e-01 0.686 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.897047e-01 0.538 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.555477e-01 0.449 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.555477e-01 0.449 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.649006e-01 0.333 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.649006e-01 0.333 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.649006e-01 0.333 0 0
C6 deamination of adenosine R-HSA-75102 4.649006e-01 0.333 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.925588e-01 0.534 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.925588e-01 0.534 0 0
Downstream signal transduction R-HSA-186763 2.265821e-01 0.645 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.741660e-01 0.427 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.475817e-01 0.606 0 0
Negative regulation of FLT3 R-HSA-9706369 3.810186e-01 0.419 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.423510e-01 0.266 0 0
MET interacts with TNS proteins R-HSA-8875513 5.423510e-01 0.266 0 0
Disorders of Developmental Biology R-HSA-9675151 4.158185e-01 0.381 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.141478e-01 0.383 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.174116e-01 0.379 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.928377e-01 0.307 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.599974e-01 0.252 0 0
Cristae formation R-HSA-8949613 5.869991e-01 0.231 0 0
Interleukin-2 family signaling R-HSA-451927 3.169282e-01 0.499 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.698155e-01 0.244 0 0
FLT3 signaling in disease R-HSA-9682385 5.081219e-01 0.294 0 0
Signaling by TGFBR3 R-HSA-9839373 4.688069e-01 0.329 0 0
Signaling by NTRKs R-HSA-166520 2.364396e-01 0.626 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.595467e-01 0.444 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.110472e-01 0.507 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.851247e-01 0.733 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.471272e-01 0.350 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.293593e-01 0.276 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.236455e-01 0.650 0 0
Signaling by ERBB4 R-HSA-1236394 4.068062e-01 0.391 0 0
PI Metabolism R-HSA-1483255 1.259509e-01 0.900 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.460027e-01 0.461 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.711498e-01 0.567 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.611515e-01 0.583 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.897047e-01 0.538 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.138107e-01 0.503 0 0
Cardiogenesis R-HSA-9733709 4.091229e-01 0.388 0 0
Platelet sensitization by LDL R-HSA-432142 4.838210e-01 0.315 0 0
L1CAM interactions R-HSA-373760 4.694090e-01 0.328 0 0
Protein methylation R-HSA-8876725 5.701438e-01 0.244 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.760512e-01 0.559 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.460027e-01 0.461 0 0
Signaling by KIT in disease R-HSA-9669938 4.443832e-01 0.352 0 0
Formation of the nephric duct R-HSA-9830364 3.569245e-01 0.447 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.816513e-01 0.418 0 0
Interleukin-1 processing R-HSA-448706 1.210975e-01 0.917 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.988334e-01 0.525 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.555477e-01 0.449 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.764571e-01 0.558 0 0
LGI-ADAM interactions R-HSA-5682910 3.741660e-01 0.427 0 0
Syndecan interactions R-HSA-3000170 3.026245e-01 0.519 0 0
RAB geranylgeranylation R-HSA-8873719 1.851247e-01 0.733 0 0
CHL1 interactions R-HSA-447041 4.631124e-01 0.334 0 0
Disorders of Nervous System Development R-HSA-9697154 4.564817e-01 0.341 0 0
Pervasive developmental disorders R-HSA-9005895 4.564817e-01 0.341 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.564817e-01 0.341 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.443832e-01 0.352 0 0
Protein hydroxylation R-HSA-9629569 5.484251e-01 0.261 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.707584e-01 0.244 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.109066e-01 0.292 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.816513e-01 0.418 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.240256e-01 0.373 0 0
Glycolysis R-HSA-70171 3.769494e-01 0.424 0 0
Diseases of DNA repair R-HSA-9675135 2.298227e-01 0.639 0 0
Signaling by ALK R-HSA-201556 2.958521e-01 0.529 0 0
Ion channel transport R-HSA-983712 4.198760e-01 0.377 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.210975e-01 0.917 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.071068e-01 0.684 0 0
Stimuli-sensing channels R-HSA-2672351 2.550634e-01 0.593 0 0
RUNX2 regulates bone development R-HSA-8941326 5.081219e-01 0.294 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.794024e-01 0.319 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.550618e-01 0.809 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.589016e-01 0.445 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.966629e-01 0.528 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.789884e-01 0.237 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.062615e-01 0.686 0 0
Other interleukin signaling R-HSA-449836 3.226781e-01 0.491 0 0
Ion transport by P-type ATPases R-HSA-936837 5.703929e-01 0.244 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.621666e-01 0.790 0 0
Interleukin-6 signaling R-HSA-1059683 4.959212e-01 0.305 0 0
Synthesis of PI R-HSA-1483226 3.741660e-01 0.427 0 0
Formation of the anterior neural plate R-HSA-9823739 3.460027e-01 0.461 0 0
Alpha-defensins R-HSA-1462054 5.128214e-01 0.290 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.698155e-01 0.244 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.030351e-01 0.298 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.997819e-01 0.699 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.379346e-01 0.624 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.933788e-01 0.227 0 0
Histamine receptors R-HSA-390650 5.423510e-01 0.266 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.555249e-01 0.255 0 0
Glucose metabolism R-HSA-70326 5.719868e-01 0.243 0 0
Interleukin-7 signaling R-HSA-1266695 5.321379e-01 0.274 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.555477e-01 0.449 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.649006e-01 0.333 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.631124e-01 0.334 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.631124e-01 0.334 0 0
Interleukin-18 signaling R-HSA-9012546 5.128214e-01 0.290 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.816513e-01 0.418 0 0
Depyrimidination R-HSA-73928 3.816513e-01 0.418 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.974429e-01 0.705 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.248248e-01 0.648 0 0
Regulation of beta-cell development R-HSA-186712 4.759850e-01 0.322 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.593925e-01 0.252 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.315914e-01 0.881 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.631124e-01 0.334 0 0
FasL/ CD95L signaling R-HSA-75157 5.423510e-01 0.266 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.128214e-01 0.290 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.593925e-01 0.252 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.567798e-01 0.448 0 0
Interleukin-15 signaling R-HSA-8983432 4.564817e-01 0.341 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.593925e-01 0.252 0 0
Interleukin-12 signaling R-HSA-9020591 5.514052e-01 0.259 0 0
HDL assembly R-HSA-8963896 5.338693e-01 0.273 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.941801e-01 0.226 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.941801e-01 0.226 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.951357e-01 0.225 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.987445e-01 0.223 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.987445e-01 0.223 0 0
snRNP Assembly R-HSA-191859 5.999891e-01 0.222 0 0
Metabolism of non-coding RNA R-HSA-194441 5.999891e-01 0.222 0 0
Diseases of Immune System R-HSA-5260271 6.008050e-01 0.221 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.008050e-01 0.221 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.008395e-01 0.221 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.009605e-01 0.221 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.026924e-01 0.220 0 0
2-LTR circle formation R-HSA-164843 6.026924e-01 0.220 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.026924e-01 0.220 0 0
Arachidonate production from DAG R-HSA-426048 6.026924e-01 0.220 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.026924e-01 0.220 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.026924e-01 0.220 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.026924e-01 0.220 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.026924e-01 0.220 0 0
Signaling by Leptin R-HSA-2586552 6.026924e-01 0.220 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.037511e-01 0.219 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.046158e-01 0.219 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.046158e-01 0.219 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.046158e-01 0.219 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.046158e-01 0.219 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.069839e-01 0.217 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.085275e-01 0.216 0 0
HCN channels R-HSA-1296061 6.085950e-01 0.216 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.085950e-01 0.216 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 6.085950e-01 0.216 0 0
Regulation of gap junction activity R-HSA-191650 6.085950e-01 0.216 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.085950e-01 0.216 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.085950e-01 0.216 0 0
Transmission across Electrical Synapses R-HSA-112307 6.085950e-01 0.216 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.085950e-01 0.216 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 6.085950e-01 0.216 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.085950e-01 0.216 0 0
Sensory perception of sour taste R-HSA-9729555 6.085950e-01 0.216 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.085950e-01 0.216 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.127931e-01 0.213 0 0
Telomere Extension By Telomerase R-HSA-171319 6.130701e-01 0.212 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.130701e-01 0.212 0 0
Pyroptosis R-HSA-5620971 6.130701e-01 0.212 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.147285e-01 0.211 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.182770e-01 0.209 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.182890e-01 0.209 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.182890e-01 0.209 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.182890e-01 0.209 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.182890e-01 0.209 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.182890e-01 0.209 0 0
Signaling by Hedgehog R-HSA-5358351 6.266423e-01 0.203 0 0
Recycling pathway of L1 R-HSA-437239 6.271757e-01 0.203 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.361552e-01 0.196 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.361552e-01 0.196 0 0
Aquaporin-mediated transport R-HSA-445717 6.361552e-01 0.196 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.366644e-01 0.196 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.366644e-01 0.196 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.366644e-01 0.196 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.372023e-01 0.196 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.372023e-01 0.196 0 0
Phase 2 - plateau phase R-HSA-5576893 6.372023e-01 0.196 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.372023e-01 0.196 0 0
Response to metal ions R-HSA-5660526 6.372023e-01 0.196 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.375172e-01 0.196 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.375172e-01 0.196 0 0
Interleukin-12 family signaling R-HSA-447115 6.378717e-01 0.195 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.381527e-01 0.195 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.381527e-01 0.195 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.381527e-01 0.195 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.381527e-01 0.195 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.381527e-01 0.195 0 0
Oncogene Induced Senescence R-HSA-2559585 6.406101e-01 0.193 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.426925e-01 0.192 0 0
Formation of the posterior neural plate R-HSA-9832991 6.426925e-01 0.192 0 0
Interleukin-2 signaling R-HSA-9020558 6.426925e-01 0.192 0 0
Bicarbonate transporters R-HSA-425381 6.426925e-01 0.192 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 6.426925e-01 0.192 0 0
Transport of RCbl within the body R-HSA-9758890 6.426925e-01 0.192 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.426925e-01 0.192 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.435675e-01 0.191 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.435675e-01 0.191 0 0
MHC class II antigen presentation R-HSA-2132295 6.500341e-01 0.187 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.535643e-01 0.185 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.586609e-01 0.181 0 0
Signaling by NOTCH1 R-HSA-1980143 6.604213e-01 0.180 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.622031e-01 0.179 0 0
DAP12 signaling R-HSA-2424491 6.622031e-01 0.179 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.622031e-01 0.179 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.622031e-01 0.179 0 0
Activation of BH3-only proteins R-HSA-114452 6.622031e-01 0.179 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.622031e-01 0.179 0 0
GPVI-mediated activation cascade R-HSA-114604 6.625915e-01 0.179 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.634519e-01 0.178 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.634519e-01 0.178 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.652535e-01 0.177 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.652535e-01 0.177 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.652535e-01 0.177 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.652535e-01 0.177 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.652535e-01 0.177 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.652535e-01 0.177 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.652535e-01 0.177 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.652535e-01 0.177 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.652535e-01 0.177 0 0
PTK6 Down-Regulation R-HSA-8849472 6.652535e-01 0.177 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.678597e-01 0.175 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.678597e-01 0.175 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.678597e-01 0.175 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.704964e-01 0.174 0 0
Interleukin-17 signaling R-HSA-448424 6.731010e-01 0.172 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.737349e-01 0.172 0 0
Selenocysteine synthesis R-HSA-2408557 6.737349e-01 0.172 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.794407e-01 0.168 0 0
ERKs are inactivated R-HSA-202670 6.794407e-01 0.168 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.794407e-01 0.168 0 0
Sodium/Calcium exchangers R-HSA-425561 6.794407e-01 0.168 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.794407e-01 0.168 0 0
Integration of provirus R-HSA-162592 6.794407e-01 0.168 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.794407e-01 0.168 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.837099e-01 0.165 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.837099e-01 0.165 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.841537e-01 0.165 0 0
PI3K Cascade R-HSA-109704 6.841788e-01 0.165 0 0
IRS-mediated signalling R-HSA-112399 6.853710e-01 0.164 0 0
IGF1R signaling cascade R-HSA-2428924 6.869346e-01 0.163 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.888604e-01 0.162 0 0
Complex III assembly R-HSA-9865881 6.888604e-01 0.162 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.888604e-01 0.162 0 0
GAB1 signalosome R-HSA-180292 6.965770e-01 0.157 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.965770e-01 0.157 0 0
Tie2 Signaling R-HSA-210993 6.965770e-01 0.157 0 0
Nephron development R-HSA-9831926 6.965770e-01 0.157 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.965770e-01 0.157 0 0
Viral mRNA Translation R-HSA-192823 6.997159e-01 0.155 0 0
HIV Life Cycle R-HSA-162587 7.006906e-01 0.154 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.024062e-01 0.153 0 0
Amine ligand-binding receptors R-HSA-375280 7.024062e-01 0.153 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.028650e-01 0.153 0 0
MET promotes cell motility R-HSA-8875878 7.039454e-01 0.152 0 0
Vesicle-mediated transport R-HSA-5653656 7.049701e-01 0.152 0 0
Chromosome Maintenance R-HSA-73886 7.067989e-01 0.151 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.070956e-01 0.151 0 0
Transmission across Chemical Synapses R-HSA-112315 7.097877e-01 0.149 0 0
Telomere Maintenance R-HSA-157579 7.103505e-01 0.149 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.128775e-01 0.147 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.130402e-01 0.147 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.130402e-01 0.147 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.130402e-01 0.147 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.130402e-01 0.147 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.130402e-01 0.147 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.130402e-01 0.147 0 0
Estrogen biosynthesis R-HSA-193144 7.130402e-01 0.147 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.130402e-01 0.147 0 0
OAS antiviral response R-HSA-8983711 7.130402e-01 0.147 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.130402e-01 0.147 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.137131e-01 0.146 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.137131e-01 0.146 0 0
PDE3B signalling R-HSA-165160 7.137131e-01 0.146 0 0
PKB-mediated events R-HSA-109703 7.137131e-01 0.146 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.137131e-01 0.146 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.137131e-01 0.146 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.137131e-01 0.146 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.137131e-01 0.146 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.137131e-01 0.146 0 0
Ceramide signalling R-HSA-193681 7.137131e-01 0.146 0 0
Synthesis of PS R-HSA-1483101 7.137131e-01 0.146 0 0
Formation of the Editosome R-HSA-75094 7.137131e-01 0.146 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.137131e-01 0.146 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.137131e-01 0.146 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.137131e-01 0.146 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.137131e-01 0.146 0 0
TRAIL signaling R-HSA-75158 7.137131e-01 0.146 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.158553e-01 0.145 0 0
Triglyceride metabolism R-HSA-8979227 7.183287e-01 0.144 0 0
Ca2+ pathway R-HSA-4086398 7.186777e-01 0.143 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.189964e-01 0.143 0 0
Signaling by MET R-HSA-6806834 7.194181e-01 0.143 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.205227e-01 0.142 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.205227e-01 0.142 0 0
Regulation of insulin secretion R-HSA-422356 7.229662e-01 0.141 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.232859e-01 0.141 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.233707e-01 0.141 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.233707e-01 0.141 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.279099e-01 0.138 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.354118e-01 0.133 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.378738e-01 0.132 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.417260e-01 0.130 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.436324e-01 0.129 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.436324e-01 0.129 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.436324e-01 0.129 0 0
Processing of SMDT1 R-HSA-8949664 7.436324e-01 0.129 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.436324e-01 0.129 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.436324e-01 0.129 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.436324e-01 0.129 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.436324e-01 0.129 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.436324e-01 0.129 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.436324e-01 0.129 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.436324e-01 0.129 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.466925e-01 0.127 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.476343e-01 0.126 0 0
Platelet homeostasis R-HSA-418346 7.478560e-01 0.126 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.482787e-01 0.126 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.482787e-01 0.126 0 0
Signaling by NODAL R-HSA-1181150 7.482787e-01 0.126 0 0
Negative regulation of MET activity R-HSA-6807004 7.482787e-01 0.126 0 0
Creatine metabolism R-HSA-71288 7.482787e-01 0.126 0 0
Signal transduction by L1 R-HSA-445144 7.482787e-01 0.126 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.511578e-01 0.124 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.514125e-01 0.124 0 0
Integration of energy metabolism R-HSA-163685 7.531955e-01 0.123 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.551599e-01 0.122 0 0
STAT5 Activation R-HSA-9645135 7.551599e-01 0.122 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.551599e-01 0.122 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.551599e-01 0.122 0 0
NADPH regeneration R-HSA-389542 7.551599e-01 0.122 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.551599e-01 0.122 0 0
Lipid particle organization R-HSA-8964572 7.551599e-01 0.122 0 0
Leukotriene receptors R-HSA-391906 7.551599e-01 0.122 0 0
Nef and signal transduction R-HSA-164944 7.551599e-01 0.122 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.553161e-01 0.122 0 0
Gastrulation R-HSA-9758941 7.558385e-01 0.122 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.567618e-01 0.121 0 0
Insulin processing R-HSA-264876 7.567618e-01 0.121 0 0
Synthesis of DNA R-HSA-69239 7.590658e-01 0.120 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.592671e-01 0.120 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.592671e-01 0.120 0 0
Adipogenesis R-HSA-9843745 7.619899e-01 0.118 0 0
Neutrophil degranulation R-HSA-6798695 7.646379e-01 0.117 0 0
Signaling by NOTCH3 R-HSA-9012852 7.662336e-01 0.116 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.662777e-01 0.116 0 0
Mitophagy R-HSA-5205647 7.662777e-01 0.116 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.662777e-01 0.116 0 0
GPER1 signaling R-HSA-9634597 7.702740e-01 0.113 0 0
Base Excision Repair R-HSA-73884 7.706149e-01 0.113 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.713564e-01 0.113 0 0
Lagging Strand Synthesis R-HSA-69186 7.713564e-01 0.113 0 0
ERK/MAPK targets R-HSA-198753 7.713564e-01 0.113 0 0
Basigin interactions R-HSA-210991 7.713564e-01 0.113 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.713564e-01 0.113 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.713564e-01 0.113 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.713838e-01 0.113 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.713838e-01 0.113 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.713838e-01 0.113 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.713838e-01 0.113 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.713838e-01 0.113 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.713838e-01 0.113 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.759156e-01 0.110 0 0
HIV Transcription Initiation R-HSA-167161 7.759156e-01 0.110 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.759156e-01 0.110 0 0
Intra-Golgi traffic R-HSA-6811438 7.759156e-01 0.110 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.766710e-01 0.110 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.766710e-01 0.110 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.771700e-01 0.109 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.806417e-01 0.108 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.806417e-01 0.108 0 0
Signaling by FGFR1 R-HSA-5654736 7.806417e-01 0.108 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.812487e-01 0.107 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.838563e-01 0.106 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.838563e-01 0.106 0 0
Signalling to ERKs R-HSA-187687 7.838563e-01 0.106 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.873627e-01 0.104 0 0
Insulin receptor signalling cascade R-HSA-74751 7.903969e-01 0.102 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.906082e-01 0.102 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.906082e-01 0.102 0 0
Netrin mediated repulsion signals R-HSA-418886 7.906082e-01 0.102 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.906082e-01 0.102 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.906082e-01 0.102 0 0
Recycling of eIF2:GDP R-HSA-72731 7.906082e-01 0.102 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.906082e-01 0.102 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.906082e-01 0.102 0 0
Glycoprotein hormones R-HSA-209822 7.906082e-01 0.102 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.906082e-01 0.102 0 0
Maturation of replicase proteins R-HSA-9694301 7.906082e-01 0.102 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.916835e-01 0.101 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.926724e-01 0.101 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.926724e-01 0.101 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.926724e-01 0.101 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.926724e-01 0.101 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.926724e-01 0.101 0 0
mRNA Capping R-HSA-72086 7.952692e-01 0.099 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.964755e-01 0.099 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.964755e-01 0.099 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.964755e-01 0.099 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.964755e-01 0.099 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.964755e-01 0.099 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.964755e-01 0.099 0 0
DNA Damage Reversal R-HSA-73942 7.964755e-01 0.099 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.995799e-01 0.097 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.995799e-01 0.097 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.996368e-01 0.097 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.003923e-01 0.097 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.003923e-01 0.097 0 0
RNA Polymerase III Transcription R-HSA-74158 8.003923e-01 0.097 0 0
Developmental Biology R-HSA-1266738 8.042078e-01 0.095 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.058283e-01 0.094 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.065866e-01 0.093 0 0
Dual incision in TC-NER R-HSA-6782135 8.074797e-01 0.093 0 0
Signaling by FGFR2 R-HSA-5654738 8.082333e-01 0.092 0 0
PKR-mediated signaling R-HSA-9833482 8.082333e-01 0.092 0 0
Mitochondrial biogenesis R-HSA-1592230 8.092718e-01 0.092 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.123049e-01 0.090 0 0
FGFR2 alternative splicing R-HSA-6803529 8.123049e-01 0.090 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.123049e-01 0.090 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.123049e-01 0.090 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.123049e-01 0.090 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.125985e-01 0.090 0 0
Degradation of DVL R-HSA-4641258 8.159129e-01 0.088 0 0
Voltage gated Potassium channels R-HSA-1296072 8.159129e-01 0.088 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.159129e-01 0.088 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.190958e-01 0.087 0 0
Regulation of BACH1 activity R-HSA-9708530 8.190958e-01 0.087 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.190958e-01 0.087 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.190958e-01 0.087 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.190958e-01 0.087 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.190984e-01 0.087 0 0
Extension of Telomeres R-HSA-180786 8.199286e-01 0.086 0 0
DAP12 interactions R-HSA-2172127 8.206447e-01 0.086 0 0
RSK activation R-HSA-444257 8.209261e-01 0.086 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.209261e-01 0.086 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.209261e-01 0.086 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.209261e-01 0.086 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.209261e-01 0.086 0 0
Sodium/Proton exchangers R-HSA-425986 8.209261e-01 0.086 0 0
Interleukin-9 signaling R-HSA-8985947 8.209261e-01 0.086 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.209261e-01 0.086 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.209261e-01 0.086 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.238639e-01 0.084 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.260499e-01 0.083 0 0
Kidney development R-HSA-9830369 8.265927e-01 0.083 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.287071e-01 0.082 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.287071e-01 0.082 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.287071e-01 0.082 0 0
Budding and maturation of HIV virion R-HSA-162588 8.287071e-01 0.082 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.303388e-01 0.081 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.303388e-01 0.081 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.303388e-01 0.081 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.303388e-01 0.081 0 0
Growth hormone receptor signaling R-HSA-982772 8.303388e-01 0.081 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.304495e-01 0.081 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.314130e-01 0.080 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.317470e-01 0.080 0 0
Ribosome-associated quality control R-HSA-9948299 8.325362e-01 0.080 0 0
Circadian clock R-HSA-9909396 8.332598e-01 0.079 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.338805e-01 0.079 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.338805e-01 0.079 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.338805e-01 0.079 0 0
Co-inhibition by PD-1 R-HSA-389948 8.380870e-01 0.077 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.381902e-01 0.077 0 0
HIV Infection R-HSA-162906 8.391812e-01 0.076 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.394295e-01 0.076 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.394344e-01 0.076 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.394344e-01 0.076 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.394344e-01 0.076 0 0
Passive transport by Aquaporins R-HSA-432047 8.394344e-01 0.076 0 0
Synthesis of PG R-HSA-1483148 8.394344e-01 0.076 0 0
Platelet degranulation R-HSA-114608 8.420783e-01 0.075 0 0
DNA strand elongation R-HSA-69190 8.436471e-01 0.074 0 0
Stabilization of p53 R-HSA-69541 8.440369e-01 0.074 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.440369e-01 0.074 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.463194e-01 0.072 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.463194e-01 0.072 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.468557e-01 0.072 0 0
Unwinding of DNA R-HSA-176974 8.468557e-01 0.072 0 0
Interleukin-21 signaling R-HSA-9020958 8.468557e-01 0.072 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.468557e-01 0.072 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.468557e-01 0.072 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.468557e-01 0.072 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.468557e-01 0.072 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.468557e-01 0.072 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.468557e-01 0.072 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.468634e-01 0.072 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.468634e-01 0.072 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.468634e-01 0.072 0 0
Interleukin-6 family signaling R-HSA-6783589 8.468634e-01 0.072 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.468634e-01 0.072 0 0
Translation initiation complex formation R-HSA-72649 8.496453e-01 0.071 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.507561e-01 0.070 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.528705e-01 0.069 0 0
Signaling by PDGF R-HSA-186797 8.535523e-01 0.069 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.544080e-01 0.068 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.567125e-01 0.067 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.567125e-01 0.067 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.567125e-01 0.067 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.567125e-01 0.067 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.567125e-01 0.067 0 0
Glycogen metabolism R-HSA-8982491 8.567125e-01 0.067 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.574736e-01 0.067 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.576180e-01 0.067 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.576775e-01 0.067 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.576775e-01 0.067 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.576775e-01 0.067 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.579890e-01 0.067 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.579890e-01 0.067 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.595029e-01 0.066 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.604366e-01 0.065 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.604366e-01 0.065 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.619701e-01 0.065 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.619701e-01 0.065 0 0
G protein gated Potassium channels R-HSA-1296059 8.619701e-01 0.065 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.619701e-01 0.065 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.619701e-01 0.065 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.619701e-01 0.065 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.619701e-01 0.065 0 0
IRE1alpha activates chaperones R-HSA-381070 8.628806e-01 0.064 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.685155e-01 0.061 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.685155e-01 0.061 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.685155e-01 0.061 0 0
Toll-like Receptor Cascades R-HSA-168898 8.686089e-01 0.061 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.690320e-01 0.061 0 0
DNA replication initiation R-HSA-68952 8.690320e-01 0.061 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.690320e-01 0.061 0 0
Josephin domain DUBs R-HSA-5689877 8.690320e-01 0.061 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.690320e-01 0.061 0 0
Pexophagy R-HSA-9664873 8.690320e-01 0.061 0 0
Interleukin-27 signaling R-HSA-9020956 8.690320e-01 0.061 0 0
Maturation of spike protein R-HSA-9683686 8.690320e-01 0.061 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.690320e-01 0.061 0 0
Sperm Motility And Taxes R-HSA-1300642 8.690320e-01 0.061 0 0
Peptide hormone biosynthesis R-HSA-209952 8.690320e-01 0.061 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.690320e-01 0.061 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.702435e-01 0.060 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.702435e-01 0.060 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.705871e-01 0.060 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.708733e-01 0.060 0 0
Signaling by NOTCH R-HSA-157118 8.724058e-01 0.059 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.740055e-01 0.058 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.740055e-01 0.058 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.757506e-01 0.058 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.757506e-01 0.058 0 0
Cellular response to starvation R-HSA-9711097 8.780368e-01 0.056 0 0
DNA Damage Bypass R-HSA-73893 8.791372e-01 0.056 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.794863e-01 0.056 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.794863e-01 0.056 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.820148e-01 0.055 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.820148e-01 0.055 0 0
Nuclear import of Rev protein R-HSA-180746 8.820148e-01 0.055 0 0
Amyloid fiber formation R-HSA-977225 8.869963e-01 0.052 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.879981e-01 0.052 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.879981e-01 0.052 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.879981e-01 0.052 0 0
vRNP Assembly R-HSA-192905 8.879981e-01 0.052 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.879981e-01 0.052 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.879981e-01 0.052 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.879981e-01 0.052 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.879981e-01 0.052 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.879981e-01 0.052 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.879981e-01 0.052 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.882960e-01 0.051 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.882960e-01 0.051 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.885905e-01 0.051 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.890608e-01 0.051 0 0
DNA Replication R-HSA-69306 8.905764e-01 0.050 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.923505e-01 0.049 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.928457e-01 0.049 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.928457e-01 0.049 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.990912e-01 0.046 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.996132e-01 0.046 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.996132e-01 0.046 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.996952e-01 0.046 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.996952e-01 0.046 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.996952e-01 0.046 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.015946e-01 0.045 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.027938e-01 0.044 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 9.042186e-01 0.044 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.042186e-01 0.044 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 9.042186e-01 0.044 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 9.042186e-01 0.044 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 9.042186e-01 0.044 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.042186e-01 0.044 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.042186e-01 0.044 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.042186e-01 0.044 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.042186e-01 0.044 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 9.042186e-01 0.044 0 0
GABA receptor activation R-HSA-977443 9.052644e-01 0.043 0 0
Proteasome assembly R-HSA-9907900 9.078191e-01 0.042 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.093418e-01 0.041 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.100343e-01 0.041 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.100343e-01 0.041 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.112543e-01 0.040 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.119158e-01 0.040 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.119158e-01 0.040 0 0
Potential therapeutics for SARS R-HSA-9679191 9.123821e-01 0.040 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.131698e-01 0.039 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.131698e-01 0.039 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.131917e-01 0.039 0 0
Influenza Infection R-HSA-168255 9.155730e-01 0.038 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.158745e-01 0.038 0 0
MET activates RAS signaling R-HSA-8851805 9.180908e-01 0.037 0 0
Regulation of IFNG signaling R-HSA-877312 9.180908e-01 0.037 0 0
Interleukin-35 Signalling R-HSA-8984722 9.180908e-01 0.037 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.180908e-01 0.037 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.180908e-01 0.037 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.180908e-01 0.037 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.180908e-01 0.037 0 0
Adaptive Immune System R-HSA-1280218 9.186475e-01 0.037 0 0
Nucleotide Excision Repair R-HSA-5696398 9.191839e-01 0.037 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.193962e-01 0.036 0 0
Mitochondrial protein import R-HSA-1268020 9.194004e-01 0.036 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.194004e-01 0.036 0 0
Interferon gamma signaling R-HSA-877300 9.196871e-01 0.036 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.202670e-01 0.036 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.206802e-01 0.036 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.233029e-01 0.035 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.234572e-01 0.035 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.234572e-01 0.035 0 0
Assembly Of The HIV Virion R-HSA-175474 9.234572e-01 0.035 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.278595e-01 0.033 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.278595e-01 0.033 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.278595e-01 0.033 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.279009e-01 0.032 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.279009e-01 0.032 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.299545e-01 0.032 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.299545e-01 0.032 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.299545e-01 0.032 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.299545e-01 0.032 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.299545e-01 0.032 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.299545e-01 0.032 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.299545e-01 0.032 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.299545e-01 0.032 0 0
Chylomicron remodeling R-HSA-8963901 9.299545e-01 0.032 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.299545e-01 0.032 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.299545e-01 0.032 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.299545e-01 0.032 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.299545e-01 0.032 0 0
Maturation of nucleoprotein R-HSA-9683610 9.299545e-01 0.032 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.299545e-01 0.032 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.325869e-01 0.030 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.325869e-01 0.030 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.325869e-01 0.030 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.325869e-01 0.030 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.347153e-01 0.029 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.348212e-01 0.029 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.348688e-01 0.029 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.348688e-01 0.029 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.354991e-01 0.029 0 0
Intraflagellar transport R-HSA-5620924 9.364344e-01 0.029 0 0
Metal ion SLC transporters R-HSA-425410 9.364344e-01 0.029 0 0
Cellular response to hypoxia R-HSA-1234174 9.371663e-01 0.028 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.379321e-01 0.028 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.401005e-01 0.027 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.401005e-01 0.027 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.401005e-01 0.027 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.401005e-01 0.027 0 0
Physiological factors R-HSA-5578768 9.401005e-01 0.027 0 0
Malate-aspartate shuttle R-HSA-9856872 9.401005e-01 0.027 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.401005e-01 0.027 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.401005e-01 0.027 0 0
Ciprofloxacin ADME R-HSA-9793528 9.401005e-01 0.027 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.401005e-01 0.027 0 0
Signal regulatory protein family interactions R-HSA-391160 9.401005e-01 0.027 0 0
P2Y receptors R-HSA-417957 9.401005e-01 0.027 0 0
Zinc transporters R-HSA-435354 9.401005e-01 0.027 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.401005e-01 0.027 0 0
Maturation of spike protein R-HSA-9694548 9.412201e-01 0.026 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.412201e-01 0.026 0 0
Host Interactions of HIV factors R-HSA-162909 9.438090e-01 0.025 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.449255e-01 0.025 0 0
Protein ubiquitination R-HSA-8852135 9.456578e-01 0.024 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.470014e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.478409e-01 0.023 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.478409e-01 0.023 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.478409e-01 0.023 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.485836e-01 0.023 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.485836e-01 0.023 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.485836e-01 0.023 0 0
Heme degradation R-HSA-189483 9.485836e-01 0.023 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.487773e-01 0.023 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.487773e-01 0.023 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.487773e-01 0.023 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.487773e-01 0.023 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.487773e-01 0.023 0 0
Translesion synthesis by REV1 R-HSA-110312 9.487773e-01 0.023 0 0
Signaling by Activin R-HSA-1502540 9.487773e-01 0.023 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.487773e-01 0.023 0 0
Protein repair R-HSA-5676934 9.487773e-01 0.023 0 0
Other semaphorin interactions R-HSA-416700 9.487773e-01 0.023 0 0
Inositol phosphate metabolism R-HSA-1483249 9.492938e-01 0.023 0 0
Activation of GABAB receptors R-HSA-991365 9.522573e-01 0.021 0 0
GABA B receptor activation R-HSA-977444 9.522573e-01 0.021 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.522683e-01 0.021 0 0
Signaling by FGFR R-HSA-190236 9.522683e-01 0.021 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.523668e-01 0.021 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.523879e-01 0.021 0 0
Dual Incision in GG-NER R-HSA-5696400 9.541559e-01 0.020 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.541559e-01 0.020 0 0
eNOS activation R-HSA-203615 9.541559e-01 0.020 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.541559e-01 0.020 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.541559e-01 0.020 0 0
Signaling by Insulin receptor R-HSA-74752 9.559572e-01 0.020 0 0
Translesion synthesis by POLI R-HSA-5656121 9.561977e-01 0.019 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.561977e-01 0.019 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.561977e-01 0.019 0 0
Killing mechanisms R-HSA-9664420 9.561977e-01 0.019 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.561977e-01 0.019 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.561977e-01 0.019 0 0
Activation of SMO R-HSA-5635838 9.561977e-01 0.019 0 0
Fructose catabolism R-HSA-70350 9.561977e-01 0.019 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.561977e-01 0.019 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.561977e-01 0.019 0 0
Atorvastatin ADME R-HSA-9754706 9.561977e-01 0.019 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.568096e-01 0.019 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.568096e-01 0.019 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.570296e-01 0.019 0 0
PCP/CE pathway R-HSA-4086400 9.576102e-01 0.019 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.576840e-01 0.019 0 0
Phospholipid metabolism R-HSA-1483257 9.589273e-01 0.018 0 0
PERK regulates gene expression R-HSA-381042 9.591592e-01 0.018 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.591592e-01 0.018 0 0
Regulation of Apoptosis R-HSA-169911 9.591592e-01 0.018 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.592404e-01 0.018 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.597667e-01 0.018 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.597667e-01 0.018 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.597667e-01 0.018 0 0
Abacavir ADME R-HSA-2161522 9.597667e-01 0.018 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.597667e-01 0.018 0 0
Parasitic Infection Pathways R-HSA-9824443 9.600346e-01 0.018 0 0
Leishmania infection R-HSA-9658195 9.600346e-01 0.018 0 0
Mitochondrial protein degradation R-HSA-9837999 9.623038e-01 0.017 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.625435e-01 0.017 0 0
Translesion synthesis by POLK R-HSA-5655862 9.625435e-01 0.017 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.625435e-01 0.017 0 0
Coenzyme A biosynthesis R-HSA-196783 9.625435e-01 0.017 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.625435e-01 0.017 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.625435e-01 0.017 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.636462e-01 0.016 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.642103e-01 0.016 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.647014e-01 0.016 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.647014e-01 0.016 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.647014e-01 0.016 0 0
rRNA processing R-HSA-72312 9.649666e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.652781e-01 0.015 0 0
Somitogenesis R-HSA-9824272 9.652781e-01 0.015 0 0
Degradation of AXIN R-HSA-4641257 9.676658e-01 0.014 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.679702e-01 0.014 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.679702e-01 0.014 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.679702e-01 0.014 0 0
Catecholamine biosynthesis R-HSA-209905 9.679702e-01 0.014 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.679702e-01 0.014 0 0
Choline catabolism R-HSA-6798163 9.679702e-01 0.014 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.679702e-01 0.014 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.688258e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.690511e-01 0.014 0 0
Pyrimidine salvage R-HSA-73614 9.690511e-01 0.014 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.702957e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.710404e-01 0.013 0 0
Signaling by NOTCH4 R-HSA-9013694 9.714911e-01 0.013 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.720326e-01 0.012 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.726110e-01 0.012 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.726110e-01 0.012 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.726110e-01 0.012 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.726110e-01 0.012 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.726110e-01 0.012 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.726110e-01 0.012 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.726110e-01 0.012 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.726110e-01 0.012 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.726110e-01 0.012 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.726110e-01 0.012 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.728817e-01 0.012 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.736212e-01 0.012 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.739833e-01 0.011 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.744784e-01 0.011 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.746990e-01 0.011 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.763943e-01 0.010 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.763943e-01 0.010 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.765796e-01 0.010 0 0
Maturation of nucleoprotein R-HSA-9694631 9.765796e-01 0.010 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.765796e-01 0.010 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.773501e-01 0.010 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.773762e-01 0.010 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.774246e-01 0.010 0 0
Gap junction trafficking and regulation R-HSA-157858 9.775405e-01 0.010 0 0
Developmental Cell Lineages R-HSA-9734767 9.777859e-01 0.010 0 0
Gene Silencing by RNA R-HSA-211000 9.778794e-01 0.010 0 0
HCMV Early Events R-HSA-9609690 9.783662e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.787107e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.788113e-01 0.009 0 0
Cargo concentration in the ER R-HSA-5694530 9.792157e-01 0.009 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.792157e-01 0.009 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.799125e-01 0.009 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.799734e-01 0.009 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.799734e-01 0.009 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.799734e-01 0.009 0 0
Pregnenolone biosynthesis R-HSA-196108 9.799734e-01 0.009 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.799734e-01 0.009 0 0
Interferon Signaling R-HSA-913531 9.804446e-01 0.009 0 0
The phototransduction cascade R-HSA-2514856 9.820147e-01 0.008 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.827195e-01 0.008 0 0
Collagen degradation R-HSA-1442490 9.827195e-01 0.008 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.828755e-01 0.008 0 0
G-protein activation R-HSA-202040 9.828755e-01 0.008 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.828755e-01 0.008 0 0
Signalling to RAS R-HSA-167044 9.828755e-01 0.008 0 0
Phenylalanine metabolism R-HSA-8964208 9.828755e-01 0.008 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.828755e-01 0.008 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.828755e-01 0.008 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.828755e-01 0.008 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.841047e-01 0.007 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.844468e-01 0.007 0 0
ER-Phagosome pathway R-HSA-1236974 9.852503e-01 0.006 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.853573e-01 0.006 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.853573e-01 0.006 0 0
Serine metabolism R-HSA-977347 9.853573e-01 0.006 0 0
Glutathione synthesis and recycling R-HSA-174403 9.853573e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.856360e-01 0.006 0 0
Smooth Muscle Contraction R-HSA-445355 9.856360e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.861098e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.865476e-01 0.006 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.874795e-01 0.005 0 0
Fructose metabolism R-HSA-5652084 9.874795e-01 0.005 0 0
Surfactant metabolism R-HSA-5683826 9.876517e-01 0.005 0 0
Gap junction trafficking R-HSA-190828 9.876517e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.876517e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.878678e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.878678e-01 0.005 0 0
Signaling by NOTCH2 R-HSA-1980145 9.878678e-01 0.005 0 0
G alpha (z) signalling events R-HSA-418597 9.885571e-01 0.005 0 0
Hemostasis R-HSA-109582 9.888400e-01 0.005 0 0
Iron uptake and transport R-HSA-917937 9.892244e-01 0.005 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.892942e-01 0.005 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.892942e-01 0.005 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.892942e-01 0.005 0 0
Carnitine shuttle R-HSA-200425 9.892942e-01 0.005 0 0
Interleukin-20 family signaling R-HSA-8854691 9.892942e-01 0.005 0 0
Formation of the ureteric bud R-HSA-9830674 9.892942e-01 0.005 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.892942e-01 0.005 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.892942e-01 0.005 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.892942e-01 0.005 0 0
Biosynthesis of maresins R-HSA-9018682 9.892942e-01 0.005 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.894080e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.894080e-01 0.005 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.897960e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.898576e-01 0.004 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.900567e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.907568e-01 0.004 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.908460e-01 0.004 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.908460e-01 0.004 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.908460e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.914796e-01 0.004 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.918019e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.919372e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.919372e-01 0.004 0 0
Selenoamino acid metabolism R-HSA-2408522 9.920490e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.920547e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.920547e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.920547e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.920913e-01 0.003 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.921729e-01 0.003 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.921729e-01 0.003 0 0
Fertilization R-HSA-1187000 9.921729e-01 0.003 0 0
Laminin interactions R-HSA-3000157 9.921729e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.921729e-01 0.003 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.925232e-01 0.003 0 0
MET activates PTK2 signaling R-HSA-8874081 9.933076e-01 0.003 0 0
Urea cycle R-HSA-70635 9.933076e-01 0.003 0 0
Sphingolipid catabolism R-HSA-9845614 9.933076e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.934480e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.938723e-01 0.003 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.942778e-01 0.002 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.942778e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.942778e-01 0.002 0 0
Synthesis of PE R-HSA-1483213 9.942778e-01 0.002 0 0
Signaling by BMP R-HSA-201451 9.942778e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.945783e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.946611e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.946611e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.946975e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.948424e-01 0.002 0 0
tRNA processing in the nucleus R-HSA-6784531 9.949290e-01 0.002 0 0
Insulin receptor recycling R-HSA-77387 9.951074e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.951074e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.953500e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.957298e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.958037e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.958168e-01 0.002 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.958168e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.958168e-01 0.002 0 0
Protein folding R-HSA-391251 9.959275e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.959514e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.959514e-01 0.002 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.964233e-01 0.002 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.964685e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.964762e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.966873e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.969012e-01 0.001 0 0
Defensins R-HSA-1461973 9.969340e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.969420e-01 0.001 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.969420e-01 0.001 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.969420e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.970114e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.971961e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.972839e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.973332e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.973336e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.973336e-01 0.001 0 0
Protein localization R-HSA-9609507 9.975063e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.976620e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.977646e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.978202e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.979160e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.979841e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.981738e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.982350e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.982813e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.982813e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.983595e-01 0.001 0 0
Signal amplification R-HSA-392518 9.983660e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.983660e-01 0.001 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.983660e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.983660e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.983660e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.983759e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.983759e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.984779e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.985945e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.986030e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.988057e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.988520e-01 0.000 0 0
Immune System R-HSA-168256 9.988676e-01 0.000 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.989789e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.989789e-01 0.000 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.989789e-01 0.000 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.989789e-01 0.000 0 0
Lysine catabolism R-HSA-71064 9.989789e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.990034e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.990633e-01 0.000 0 0
Elastic fibre formation R-HSA-1566948 9.991270e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.992494e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.992537e-01 0.000 0 0
RAS processing R-HSA-9648002 9.992537e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.993524e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.993524e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.993612e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.993620e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994329e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994602e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.995337e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.995337e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.995654e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.995754e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.996014e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.996060e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996197e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.996592e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.996674e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996757e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.996811e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.996811e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.997163e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.997237e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997606e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.997823e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.998180e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998205e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998266e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.998444e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.998670e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.998722e-01 0.000 0 0
Neddylation R-HSA-8951664 9.998774e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.998799e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.998863e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998992e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999057e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999128e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999177e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999183e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999411e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999436e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999436e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999466e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999512e-01 0.000 0 0
Digestion R-HSA-8935690 9.999557e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999602e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.999621e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999622e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999761e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999763e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999797e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999820e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999850e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999852e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999859e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999869e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999874e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999874e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999891e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999892e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999918e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999918e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999921e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999935e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999935e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999938e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999946e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999956e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999958e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999969e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999969e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999974e-01 0.000 0 0
Translation R-HSA-72766 9.999982e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999986e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999988e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999989e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999990e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999991e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999993e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999993e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999995e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999998e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999998e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.997602e-14 13.523 0 0
Cell Cycle, Mitotic R-HSA-69278 8.736345e-13 12.059 0 0
Chromatin organization R-HSA-4839726 3.580691e-12 11.446 0 0
M Phase R-HSA-68886 2.203782e-11 10.657 0 0
Chromatin modifying enzymes R-HSA-3247509 1.933447e-10 9.714 0 0
Cell Cycle Checkpoints R-HSA-69620 1.292439e-09 8.889 0 0
HDACs deacetylate histones R-HSA-3214815 2.205147e-09 8.657 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.242218e-09 8.649 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.840380e-09 8.547 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.840380e-09 8.547 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.498941e-09 8.456 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.151840e-09 8.382 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.538597e-09 8.257 0 0
Mitotic Prophase R-HSA-68875 8.315946e-09 8.080 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.740637e-08 7.759 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.268254e-08 7.644 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.587311e-08 7.587 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.588323e-08 7.338 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.549680e-08 7.256 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.788751e-08 7.237 0 0
Meiotic synapsis R-HSA-1221632 7.139247e-08 7.146 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.262098e-08 7.139 0 0
Interleukin-12 signaling R-HSA-9020591 7.302456e-08 7.137 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.709896e-08 7.060 0 0
Nucleosome assembly R-HSA-774815 8.709896e-08 7.060 0 0
G2/M Checkpoints R-HSA-69481 1.085961e-07 6.964 0 0
Homology Directed Repair R-HSA-5693538 1.240450e-07 6.906 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.458157e-07 6.836 0 0
Metabolism of RNA R-HSA-8953854 1.980116e-07 6.703 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.081456e-07 6.682 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.655778e-07 6.576 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.845890e-07 6.546 0 0
HATs acetylate histones R-HSA-3214847 2.860435e-07 6.544 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.946819e-07 6.404 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.112905e-07 6.386 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.271198e-07 6.369 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.216767e-07 6.375 0 0
Apoptotic execution phase R-HSA-75153 4.655311e-07 6.332 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.185135e-07 6.285 0 0
DNA Repair R-HSA-73894 6.458633e-07 6.190 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.453216e-07 6.128 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.966409e-07 6.099 0 0
DNA Double Strand Break Response R-HSA-5693606 9.005312e-07 6.046 0 0
Interleukin-12 family signaling R-HSA-447115 1.118742e-06 5.951 0 0
Cellular responses to stress R-HSA-2262752 1.193157e-06 5.923 0 0
Cellular response to heat stress R-HSA-3371556 1.461598e-06 5.835 0 0
Meiosis R-HSA-1500620 1.744007e-06 5.758 0 0
Packaging Of Telomere Ends R-HSA-171306 1.919700e-06 5.717 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.687623e-06 5.571 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.687623e-06 5.571 0 0
Defective pyroptosis R-HSA-9710421 2.659104e-06 5.575 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.020591e-06 5.520 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.020591e-06 5.520 0 0
RNA Polymerase I Transcription R-HSA-73864 3.450641e-06 5.462 0 0
Mitotic Prometaphase R-HSA-68877 3.813628e-06 5.419 0 0
Cellular responses to stimuli R-HSA-8953897 3.828517e-06 5.417 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.766443e-06 5.424 0 0
DNA methylation R-HSA-5334118 3.998671e-06 5.398 0 0
Diseases of programmed cell death R-HSA-9645723 3.868732e-06 5.412 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.314556e-06 5.365 0 0
Cell-Cell communication R-HSA-1500931 5.206832e-06 5.283 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.516392e-06 5.258 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.090653e-06 5.215 0 0
Meiotic recombination R-HSA-912446 6.542465e-06 5.184 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.616396e-06 5.179 0 0
Cellular Senescence R-HSA-2559583 7.412830e-06 5.130 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.157992e-06 5.145 0 0
Gene Silencing by RNA R-HSA-211000 1.047538e-05 4.980 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.066787e-05 4.972 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.121855e-05 4.950 0 0
mRNA Splicing R-HSA-72172 1.565748e-05 4.805 0 0
Cleavage of the damaged purine R-HSA-110331 1.740869e-05 4.759 0 0
Depurination R-HSA-73927 2.299293e-05 4.638 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.345556e-05 4.630 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.376948e-05 4.624 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.376948e-05 4.624 0 0
Deubiquitination R-HSA-5688426 2.890547e-05 4.539 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.011602e-05 4.521 0 0
Apoptosis R-HSA-109581 3.117311e-05 4.506 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.246163e-05 4.489 0 0
ESR-mediated signaling R-HSA-8939211 3.387061e-05 4.470 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.170095e-05 4.287 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.046008e-05 4.297 0 0
Membrane Trafficking R-HSA-199991 5.191895e-05 4.285 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.950357e-05 4.225 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.128777e-05 4.213 0 0
HSF1-dependent transactivation R-HSA-3371571 6.561005e-05 4.183 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.089266e-05 4.149 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.089266e-05 4.149 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.339594e-05 4.134 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.339594e-05 4.134 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.461455e-05 4.127 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.864840e-05 4.104 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.136713e-05 4.090 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.180579e-05 4.087 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.210323e-05 4.086 0 0
Depyrimidination R-HSA-73928 8.210323e-05 4.086 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.265223e-05 4.033 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.265223e-05 4.033 0 0
Base Excision Repair R-HSA-73884 9.742134e-05 4.011 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.015289e-04 3.993 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.047161e-04 3.980 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.084822e-04 3.965 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.084822e-04 3.965 0 0
Cell junction organization R-HSA-446728 1.258542e-04 3.900 0 0
Adherens junctions interactions R-HSA-418990 1.288708e-04 3.890 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.291919e-04 3.889 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.408108e-04 3.851 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.632151e-04 3.787 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.724293e-04 3.763 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.956672e-04 3.708 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.945646e-04 3.711 0 0
Mitotic Anaphase R-HSA-68882 1.985729e-04 3.702 0 0
Nervous system development R-HSA-9675108 1.870771e-04 3.728 0 0
Reproduction R-HSA-1474165 2.007069e-04 3.697 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.056487e-04 3.687 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.096926e-04 3.678 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.177091e-04 3.662 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.362074e-04 3.627 0 0
Chromosome Maintenance R-HSA-73886 2.362074e-04 3.627 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.518045e-04 3.599 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.667463e-04 3.574 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.839956e-04 3.547 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.931082e-04 3.533 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.176706e-04 3.498 0 0
snRNP Assembly R-HSA-191859 3.199806e-04 3.495 0 0
Metabolism of non-coding RNA R-HSA-194441 3.199806e-04 3.495 0 0
Nuclear import of Rev protein R-HSA-180746 3.212475e-04 3.493 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.229860e-04 3.491 0 0
Translation initiation complex formation R-HSA-72649 3.457908e-04 3.461 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.457908e-04 3.461 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.718453e-04 3.430 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.849459e-04 3.415 0 0
Attenuation phase R-HSA-3371568 4.025152e-04 3.395 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.025152e-04 3.395 0 0
Axon guidance R-HSA-422475 4.262777e-04 3.370 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.853489e-04 3.314 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.979601e-04 3.303 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.416325e-04 3.266 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.378410e-04 3.195 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.358100e-04 3.197 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.208972e-04 3.207 0 0
Separation of Sister Chromatids R-HSA-2467813 6.212505e-04 3.207 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.432217e-04 3.192 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.307586e-04 3.200 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.862897e-04 3.163 0 0
Cell-cell junction organization R-HSA-421270 6.883220e-04 3.162 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.123756e-04 3.147 0 0
DNA Replication R-HSA-69306 7.638358e-04 3.117 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.865757e-04 3.104 0 0
Influenza Infection R-HSA-168255 8.049756e-04 3.094 0 0
Striated Muscle Contraction R-HSA-390522 8.077598e-04 3.093 0 0
Programmed Cell Death R-HSA-5357801 8.092438e-04 3.092 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.127647e-04 3.090 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.326005e-04 3.080 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.768783e-04 3.057 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.427528e-04 3.074 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.072225e-04 3.042 0 0
Death Receptor Signaling R-HSA-73887 8.427528e-04 3.074 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.812804e-04 3.008 0 0
Signaling by ERBB2 R-HSA-1227986 9.812804e-04 3.008 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.020157e-03 2.991 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.092105e-03 2.962 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.099810e-03 2.959 0 0
RMTs methylate histone arginines R-HSA-3214858 1.099810e-03 2.959 0 0
Signal Transduction R-HSA-162582 1.166348e-03 2.933 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.179751e-03 2.928 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.196114e-03 2.922 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.223770e-03 2.912 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.244000e-03 2.905 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.281605e-03 2.892 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.281605e-03 2.892 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.428981e-03 2.845 0 0
Signaling by NOTCH R-HSA-157118 1.459012e-03 2.836 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.452970e-03 2.838 0 0
Ub-specific processing proteases R-HSA-5689880 1.559573e-03 2.807 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.566962e-03 2.805 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.566962e-03 2.805 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.579135e-03 2.802 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.579717e-03 2.801 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.579717e-03 2.801 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.579717e-03 2.801 0 0
Signaling by RAS mutants R-HSA-6802949 1.579717e-03 2.801 0 0
Amyloid fiber formation R-HSA-977225 1.605550e-03 2.794 0 0
Telomere Maintenance R-HSA-157579 1.713499e-03 2.766 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.725688e-03 2.763 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.760866e-03 2.754 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.761894e-03 2.754 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.830271e-03 2.737 0 0
HCMV Early Events R-HSA-9609690 1.925886e-03 2.715 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.971661e-03 2.705 0 0
PTEN Regulation R-HSA-6807070 2.283759e-03 2.641 0 0
Ribosome-associated quality control R-HSA-9948299 2.078321e-03 2.682 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.402165e-03 2.619 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.416602e-03 2.617 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.424344e-03 2.615 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.469179e-03 2.607 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.469179e-03 2.607 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.587439e-03 2.587 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.770089e-03 2.558 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.770089e-03 2.558 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.829282e-03 2.548 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.920781e-03 2.535 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.920781e-03 2.535 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.094804e-03 2.509 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.132839e-03 2.504 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.546615e-03 2.450 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.551967e-03 2.450 0 0
Centrosome maturation R-HSA-380287 3.584150e-03 2.446 0 0
Semaphorin interactions R-HSA-373755 3.669837e-03 2.435 0 0
HCMV Late Events R-HSA-9610379 3.716678e-03 2.430 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.853929e-03 2.414 0 0
Metalloprotease DUBs R-HSA-5689901 4.050346e-03 2.393 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.053879e-03 2.392 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.168433e-03 2.380 0 0
Peptide chain elongation R-HSA-156902 4.277518e-03 2.369 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.359280e-03 2.361 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.985736e-03 2.302 0 0
Regulation of TP53 Activity R-HSA-5633007 4.751886e-03 2.323 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.985736e-03 2.302 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.082623e-03 2.294 0 0
Host Interactions of HIV factors R-HSA-162909 5.111263e-03 2.291 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.223979e-03 2.282 0 0
Signaling by ROBO receptors R-HSA-376176 5.507328e-03 2.259 0 0
Kinesins R-HSA-983189 5.542385e-03 2.256 0 0
Eukaryotic Translation Termination R-HSA-72764 5.657040e-03 2.247 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.018766e-03 2.220 0 0
DCC mediated attractive signaling R-HSA-418885 6.474313e-03 2.189 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.474313e-03 2.189 0 0
HIV Life Cycle R-HSA-162587 6.485990e-03 2.188 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.711808e-03 2.173 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.947397e-03 2.158 0 0
HIV Infection R-HSA-162906 6.971515e-03 2.157 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.162291e-03 2.145 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.387161e-03 2.132 0 0
Protein ubiquitination R-HSA-8852135 7.610412e-03 2.119 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.653686e-03 2.116 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.786808e-03 2.109 0 0
RAF activation R-HSA-5673000 7.976786e-03 2.098 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.662114e-03 2.062 0 0
MET receptor recycling R-HSA-8875656 8.823801e-03 2.054 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.594901e-03 2.066 0 0
Neutrophil degranulation R-HSA-6798695 9.642751e-03 2.016 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.875384e-03 2.052 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.662114e-03 2.062 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.733609e-03 2.012 0 0
Rab regulation of trafficking R-HSA-9007101 9.138045e-03 2.039 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.823801e-03 2.054 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.794418e-03 2.009 0 0
Signaling by WNT R-HSA-195721 9.317950e-03 2.031 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.693673e-03 2.014 0 0
Nephrin family interactions R-HSA-373753 8.396033e-03 2.076 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.909863e-03 2.004 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.043870e-02 1.981 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.045097e-02 1.981 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.045097e-02 1.981 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.048926e-02 1.979 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.093776e-02 1.961 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.093776e-02 1.961 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.093776e-02 1.961 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.093776e-02 1.961 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.096011e-02 1.960 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.096011e-02 1.960 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.096011e-02 1.960 0 0
Signaling by VEGF R-HSA-194138 1.096011e-02 1.960 0 0
HSF1 activation R-HSA-3371511 1.105545e-02 1.956 0 0
Calmodulin induced events R-HSA-111933 1.105545e-02 1.956 0 0
CaM pathway R-HSA-111997 1.105545e-02 1.956 0 0
HCMV Infection R-HSA-9609646 1.160960e-02 1.935 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.175570e-02 1.930 0 0
Co-inhibition by PD-1 R-HSA-389948 1.178821e-02 1.929 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.282790e-02 1.892 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.290021e-02 1.889 0 0
Ca-dependent events R-HSA-111996 1.297194e-02 1.887 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.315877e-02 1.881 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.343925e-02 1.872 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.356229e-02 1.868 0 0
Signaling by Hippo R-HSA-2028269 1.360112e-02 1.866 0 0
EPH-Ephrin signaling R-HSA-2682334 1.407153e-02 1.852 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.697802e-02 1.770 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.697802e-02 1.770 0 0
Signaling by EGFR R-HSA-177929 1.600207e-02 1.796 0 0
Nucleotide Excision Repair R-HSA-5696398 1.599099e-02 1.796 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.473582e-02 1.832 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.473582e-02 1.832 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.697802e-02 1.770 0 0
rRNA processing R-HSA-72312 1.475424e-02 1.831 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.460523e-02 1.835 0 0
UCH proteinases R-HSA-5689603 1.704366e-02 1.768 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.721752e-02 1.764 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.760564e-02 1.754 0 0
Regulation of KIT signaling R-HSA-1433559 1.760564e-02 1.754 0 0
Regulation of CDH1 Function R-HSA-9764561 1.798920e-02 1.745 0 0
Vesicle-mediated transport R-HSA-5653656 1.902174e-02 1.721 0 0
DAG and IP3 signaling R-HSA-1489509 1.939668e-02 1.712 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.939668e-02 1.712 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.967646e-02 1.706 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.986481e-02 1.702 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.018433e-02 1.695 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.030995e-02 1.692 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.112792e-02 1.675 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.190753e-02 1.659 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.199217e-02 1.658 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.199326e-02 1.658 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.217216e-02 1.654 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.251891e-02 1.647 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.371838e-02 1.625 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.377384e-02 1.624 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.403366e-02 1.619 0 0
Signal transduction by L1 R-HSA-445144 2.510418e-02 1.600 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.510418e-02 1.600 0 0
MAP2K and MAPK activation R-HSA-5674135 2.580041e-02 1.588 0 0
L1CAM interactions R-HSA-373760 2.585331e-02 1.587 0 0
S Phase R-HSA-69242 2.606015e-02 1.584 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.613163e-02 1.583 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.653673e-02 1.576 0 0
Signaling by NOTCH4 R-HSA-9013694 2.691972e-02 1.570 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.755694e-02 1.560 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.785169e-02 1.555 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.829933e-02 1.548 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.963596e-02 1.528 0 0
G2/M Transition R-HSA-69275 2.985713e-02 1.525 0 0
Glycolysis R-HSA-70171 3.049744e-02 1.516 0 0
Regulation of gap junction activity R-HSA-191650 3.133311e-02 1.504 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.133311e-02 1.504 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.664519e-02 1.436 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.369451e-02 1.472 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.065290e-02 1.391 0 0
Integrin signaling R-HSA-354192 3.553901e-02 1.449 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.553901e-02 1.449 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.056469e-02 1.392 0 0
Viral mRNA Translation R-HSA-192823 3.833913e-02 1.416 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.733493e-02 1.428 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.369451e-02 1.472 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.569232e-02 1.447 0 0
Translation R-HSA-72766 3.835449e-02 1.416 0 0
TBC/RABGAPs R-HSA-8854214 3.295431e-02 1.482 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.649522e-02 1.438 0 0
G alpha (12/13) signalling events R-HSA-416482 3.862711e-02 1.413 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.892482e-02 1.410 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.609408e-02 1.443 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.341099e-02 1.476 0 0
NRAGE signals death through JNK R-HSA-193648 3.289799e-02 1.483 0 0
Selenocysteine synthesis R-HSA-2408557 3.296432e-02 1.482 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.357597e-02 1.474 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.289799e-02 1.483 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.140971e-02 1.383 0 0
Notch-HLH transcription pathway R-HSA-350054 4.194881e-02 1.377 0 0
Sensory processing of sound R-HSA-9659379 4.205340e-02 1.376 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.242626e-02 1.372 0 0
Neurexins and neuroligins R-HSA-6794361 4.318294e-02 1.365 0 0
Viral Infection Pathways R-HSA-9824446 4.347752e-02 1.362 0 0
Gene expression (Transcription) R-HSA-74160 4.451662e-02 1.351 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.539713e-02 1.343 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.580749e-02 1.339 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.580749e-02 1.339 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.604987e-02 1.337 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.615422e-02 1.336 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.756591e-02 1.323 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.785581e-02 1.320 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.845697e-02 1.315 0 0
Unwinding of DNA R-HSA-176974 4.853273e-02 1.314 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.853273e-02 1.314 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.878049e-02 1.312 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.878049e-02 1.312 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.878049e-02 1.312 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.878049e-02 1.312 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.878049e-02 1.312 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.913462e-02 1.309 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.913462e-02 1.309 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.913462e-02 1.309 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.959426e-02 1.305 0 0
Recycling pathway of L1 R-HSA-437239 5.125655e-02 1.290 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.200741e-02 1.284 0 0
PLC beta mediated events R-HSA-112043 5.345756e-02 1.272 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.454478e-02 1.263 0 0
Signaling by ALK in cancer R-HSA-9700206 5.454478e-02 1.263 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.457357e-02 1.263 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.457357e-02 1.263 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.712342e-02 1.243 0 0
Signaling by NOTCH3 R-HSA-9012852 5.785895e-02 1.238 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.829102e-02 1.234 0 0
tRNA processing in the nucleus R-HSA-6784531 5.843109e-02 1.233 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.844796e-02 1.233 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.138034e-02 1.212 0 0
Josephin domain DUBs R-HSA-5689877 6.138034e-02 1.212 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.138034e-02 1.212 0 0
EGFR downregulation R-HSA-182971 6.186470e-02 1.209 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.186470e-02 1.209 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.186470e-02 1.209 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.256741e-02 1.204 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.317333e-02 1.199 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.317333e-02 1.199 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.317333e-02 1.199 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.341107e-02 1.198 0 0
TNF signaling R-HSA-75893 6.341107e-02 1.198 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.341107e-02 1.198 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.358644e-02 1.197 0 0
Long-term potentiation R-HSA-9620244 6.479426e-02 1.188 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.537986e-02 1.185 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.537986e-02 1.185 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.614156e-02 1.180 0 0
mRNA Editing: A to I Conversion R-HSA-75064 7.573429e-02 1.121 0 0
Regulation of TP53 Expression R-HSA-6804754 7.573429e-02 1.121 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 7.573429e-02 1.121 0 0
C6 deamination of adenosine R-HSA-75102 7.573429e-02 1.121 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.302335e-02 1.081 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.633266e-02 1.178 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.633266e-02 1.178 0 0
Negative regulation of MET activity R-HSA-6807004 6.666077e-02 1.176 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.666077e-02 1.176 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.666077e-02 1.176 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.666077e-02 1.176 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.666077e-02 1.176 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.666077e-02 1.176 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.706938e-02 1.113 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.834177e-02 1.054 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.834177e-02 1.054 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.834177e-02 1.054 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.351117e-02 1.078 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.351117e-02 1.078 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.706938e-02 1.113 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.834177e-02 1.054 0 0
Signaling by MET R-HSA-6806834 7.900271e-02 1.102 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.809036e-02 1.167 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.031962e-02 1.095 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.633266e-02 1.178 0 0
Prolonged ERK activation events R-HSA-169893 7.850970e-02 1.105 0 0
G-protein mediated events R-HSA-112040 8.791352e-02 1.056 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.404953e-02 1.130 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.819334e-02 1.107 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.900271e-02 1.102 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.280909e-02 1.138 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.819334e-02 1.107 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.225359e-02 1.141 0 0
Cellular response to starvation R-HSA-9711097 7.169431e-02 1.145 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.850970e-02 1.105 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.724165e-02 1.172 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.199645e-02 1.086 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.351117e-02 1.078 0 0
Inositol phosphate metabolism R-HSA-1483249 7.506556e-02 1.125 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.834177e-02 1.054 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.977076e-02 1.047 0 0
Smooth Muscle Contraction R-HSA-445355 8.977076e-02 1.047 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.989264e-02 1.046 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.179900e-02 1.037 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.179900e-02 1.037 0 0
Activation of RAC1 R-HSA-428540 9.184783e-02 1.037 0 0
Integration of provirus R-HSA-162592 9.184783e-02 1.037 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.184783e-02 1.037 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.184783e-02 1.037 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.428593e-02 1.026 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.633603e-02 1.016 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.686014e-02 1.014 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.686014e-02 1.014 0 0
Signaling by NOTCH1 R-HSA-1980143 9.964384e-02 1.002 0 0
FGFR2 alternative splicing R-HSA-6803529 1.004629e-01 0.998 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.019453e-01 0.992 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.050077e-01 0.979 0 0
SOS-mediated signalling R-HSA-112412 1.051771e-01 0.978 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 1.051771e-01 0.978 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.051771e-01 0.978 0 0
CHL1 interactions R-HSA-447041 1.051771e-01 0.978 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.051771e-01 0.978 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.061646e-01 0.974 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.061646e-01 0.974 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.066506e-01 0.972 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.066506e-01 0.972 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.066506e-01 0.972 0 0
Signalling to ERKs R-HSA-187687 1.070613e-01 0.970 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.093181e-01 0.961 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.093181e-01 0.961 0 0
MET interacts with TNS proteins R-HSA-8875513 1.101320e-01 0.958 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.101320e-01 0.958 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.101320e-01 0.958 0 0
MET activates PTPN11 R-HSA-8865999 1.101320e-01 0.958 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.101720e-01 0.958 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.105937e-01 0.956 0 0
Glucose metabolism R-HSA-70326 1.116275e-01 0.952 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.119480e-01 0.951 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.134108e-01 0.945 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.134108e-01 0.945 0 0
Activation of the pre-replicative complex R-HSA-68962 1.167714e-01 0.933 0 0
Activation of BH3-only proteins R-HSA-114452 1.167714e-01 0.933 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.167714e-01 0.933 0 0
Interleukin-37 signaling R-HSA-9008059 1.167714e-01 0.933 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.171797e-01 0.931 0 0
MTOR signalling R-HSA-165159 1.174525e-01 0.930 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.174525e-01 0.930 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.178294e-01 0.929 0 0
G1/S Transition R-HSA-69206 1.193377e-01 0.923 0 0
Protein folding R-HSA-391251 1.211899e-01 0.917 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.215598e-01 0.915 0 0
Ephrin signaling R-HSA-3928664 1.215598e-01 0.915 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.215598e-01 0.915 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.252837e-01 0.902 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.252880e-01 0.902 0 0
RNA Polymerase II Transcription R-HSA-73857 1.260637e-01 0.899 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.271567e-01 0.896 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.271567e-01 0.896 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.271567e-01 0.896 0 0
Deadenylation of mRNA R-HSA-429947 1.271567e-01 0.896 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.281473e-01 0.892 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.281473e-01 0.892 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.288832e-01 0.890 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.293574e-01 0.888 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.293574e-01 0.888 0 0
Formation of annular gap junctions R-HSA-196025 1.293574e-01 0.888 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.293574e-01 0.888 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.293574e-01 0.888 0 0
Adrenoceptors R-HSA-390696 1.293574e-01 0.888 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.329634e-01 0.876 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.019325e-01 0.695 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.019325e-01 0.695 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.019325e-01 0.695 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.019325e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.019325e-01 0.695 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.019325e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.019325e-01 0.695 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.019325e-01 0.695 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.019325e-01 0.695 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.019325e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.019325e-01 0.695 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.019325e-01 0.695 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.477075e-01 0.831 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.477075e-01 0.831 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.477075e-01 0.831 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.477075e-01 0.831 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.477075e-01 0.831 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.477075e-01 0.831 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.873928e-01 0.727 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.873928e-01 0.727 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.873928e-01 0.727 0 0
IRS activation R-HSA-74713 1.873928e-01 0.727 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.873928e-01 0.727 0 0
ARMS-mediated activation R-HSA-170984 1.552730e-01 0.809 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.552730e-01 0.809 0 0
Gap junction degradation R-HSA-190873 1.552730e-01 0.809 0 0
ALK mutants bind TKIs R-HSA-9700645 1.552730e-01 0.809 0 0
2-LTR circle formation R-HSA-164843 1.826300e-01 0.738 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.826300e-01 0.738 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.482184e-01 0.829 0 0
Erythropoietin activates RAS R-HSA-9027284 1.694044e-01 0.771 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.694044e-01 0.771 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.694044e-01 0.771 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.552059e-01 0.809 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.416662e-01 0.849 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.733218e-01 0.761 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.733218e-01 0.761 0 0
DNA strand elongation R-HSA-69190 1.422373e-01 0.847 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.728122e-01 0.762 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.558902e-01 0.807 0 0
MET promotes cell motility R-HSA-8875878 1.410136e-01 0.851 0 0
mRNA 3'-end processing R-HSA-72187 1.462375e-01 0.835 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.570762e-01 0.804 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.569412e-01 0.804 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.514337e-01 0.820 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.918486e-01 0.717 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.669167e-01 0.778 0 0
PKR-mediated signaling R-HSA-9833482 2.007746e-01 0.697 0 0
G-protein beta:gamma signalling R-HSA-397795 1.558902e-01 0.807 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.568995e-01 0.804 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.500571e-01 0.824 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.740306e-01 0.759 0 0
Synthesis of DNA R-HSA-69239 1.953776e-01 0.709 0 0
DNA Damage Bypass R-HSA-73893 1.996324e-01 0.700 0 0
TGFBR3 expression R-HSA-9839394 1.416662e-01 0.849 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.826300e-01 0.738 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.387265e-01 0.858 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.873928e-01 0.727 0 0
Signal regulatory protein family interactions R-HSA-391160 1.482184e-01 0.829 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.701180e-01 0.769 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.422373e-01 0.847 0 0
p75NTR signals via NF-kB R-HSA-193639 1.694044e-01 0.771 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.568995e-01 0.804 0 0
Signal attenuation R-HSA-74749 1.826300e-01 0.738 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.019325e-01 0.695 0 0
NADE modulates death signalling R-HSA-205025 1.477075e-01 0.831 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.873928e-01 0.727 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 1.873928e-01 0.727 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.873928e-01 0.727 0 0
Opioid Signalling R-HSA-111885 1.615111e-01 0.792 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.379283e-01 0.860 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.568995e-01 0.804 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.552730e-01 0.809 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.602440e-01 0.795 0 0
HDMs demethylate histones R-HSA-3214842 1.416662e-01 0.849 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.019325e-01 0.695 0 0
Inhibition of PKR R-HSA-169131 2.019325e-01 0.695 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.477075e-01 0.831 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.873928e-01 0.727 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.552730e-01 0.809 0 0
Signaling by TGFBR3 R-HSA-9839373 1.618308e-01 0.791 0 0
Co-stimulation by CD28 R-HSA-389356 1.866379e-01 0.729 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.552730e-01 0.809 0 0
Protein methylation R-HSA-8876725 1.694044e-01 0.771 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.694044e-01 0.771 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.379283e-01 0.860 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.694044e-01 0.771 0 0
Basigin interactions R-HSA-210991 1.733218e-01 0.761 0 0
Muscle contraction R-HSA-397014 1.939768e-01 0.712 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.873928e-01 0.727 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.701180e-01 0.769 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.514337e-01 0.820 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.524241e-01 0.817 0 0
Diseases of DNA repair R-HSA-9675135 1.618308e-01 0.791 0 0
Signaling by Leptin R-HSA-2586552 1.826300e-01 0.738 0 0
SARS-CoV Infections R-HSA-9679506 1.407644e-01 0.852 0 0
Post NMDA receptor activation events R-HSA-438064 2.023026e-01 0.694 0 0
Signaling by Erythropoietin R-HSA-9006335 2.064791e-01 0.685 0 0
Late endosomal microautophagy R-HSA-9615710 2.064791e-01 0.685 0 0
MAPK family signaling cascades R-HSA-5683057 2.081102e-01 0.682 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.097816e-01 0.678 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.111399e-01 0.675 0 0
PECAM1 interactions R-HSA-210990 2.111399e-01 0.675 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.111399e-01 0.675 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.111399e-01 0.675 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.111399e-01 0.675 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.117607e-01 0.674 0 0
mTORC1-mediated signalling R-HSA-166208 2.117607e-01 0.674 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.117607e-01 0.674 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.145831e-01 0.668 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.145831e-01 0.668 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.145831e-01 0.668 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.145831e-01 0.668 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.145831e-01 0.668 0 0
Disorders of Developmental Biology R-HSA-9675151 2.145831e-01 0.668 0 0
RET signaling R-HSA-8853659 2.159090e-01 0.666 0 0
FLT3 signaling in disease R-HSA-9682385 2.159090e-01 0.666 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.241277e-01 0.650 0 0
Interferon Signaling R-HSA-913531 2.260234e-01 0.646 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.283110e-01 0.641 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.283110e-01 0.641 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.283110e-01 0.641 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.283110e-01 0.641 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.283110e-01 0.641 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.283110e-01 0.641 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.283110e-01 0.641 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.283110e-01 0.641 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.283110e-01 0.641 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.319214e-01 0.635 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.319214e-01 0.635 0 0
Netrin-1 signaling R-HSA-373752 2.373043e-01 0.625 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.383006e-01 0.623 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.383006e-01 0.623 0 0
Specification of primordial germ cells R-HSA-9827857 2.383006e-01 0.623 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.405258e-01 0.619 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.405258e-01 0.619 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.405258e-01 0.619 0 0
Orc1 removal from chromatin R-HSA-68949 2.407157e-01 0.618 0 0
Trafficking of AMPA receptors R-HSA-399719 2.422456e-01 0.616 0 0
Downstream signal transduction R-HSA-186763 2.422456e-01 0.616 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.870568e-01 0.542 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 2.870568e-01 0.542 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.870568e-01 0.542 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.870568e-01 0.542 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.870568e-01 0.542 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.870568e-01 0.542 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.870568e-01 0.542 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.870568e-01 0.542 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.870568e-01 0.542 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.870568e-01 0.542 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.631060e-01 0.440 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.697482e-01 0.569 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.697482e-01 0.569 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.697482e-01 0.569 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.111286e-01 0.507 0 0
Regulation of PTEN localization R-HSA-8948747 3.111286e-01 0.507 0 0
Netrin mediated repulsion signals R-HSA-418886 3.111286e-01 0.507 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.111286e-01 0.507 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.111286e-01 0.507 0 0
Recycling of eIF2:GDP R-HSA-72731 3.111286e-01 0.507 0 0
Disinhibition of SNARE formation R-HSA-114516 3.111286e-01 0.507 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.310471e-01 0.365 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.310471e-01 0.365 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.705272e-01 0.568 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.705272e-01 0.568 0 0
Type I hemidesmosome assembly R-HSA-446107 3.519933e-01 0.453 0 0
Regulation by c-FLIP R-HSA-3371378 3.519933e-01 0.453 0 0
Dimerization of procaspase-8 R-HSA-69416 3.519933e-01 0.453 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.009020e-01 0.522 0 0
GAB1 signalosome R-HSA-180292 2.625874e-01 0.581 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.625874e-01 0.581 0 0
Regulation of signaling by CBL R-HSA-912631 2.873099e-01 0.542 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.873099e-01 0.542 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.314293e-01 0.480 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.314293e-01 0.480 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.919817e-01 0.407 0 0
Lipophagy R-HSA-9613354 3.919817e-01 0.407 0 0
CASP8 activity is inhibited R-HSA-5218900 3.919817e-01 0.407 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.917441e-01 0.308 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.917441e-01 0.308 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.917441e-01 0.308 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.123393e-01 0.505 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.619094e-01 0.441 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.951645e-01 0.530 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.375528e-01 0.472 0 0
Binding and entry of HIV virion R-HSA-173107 4.308160e-01 0.366 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.655549e-01 0.576 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.921647e-01 0.407 0 0
Phosphorylation of the APC/C R-HSA-176412 3.921647e-01 0.407 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.921647e-01 0.407 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.387976e-01 0.470 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.387976e-01 0.470 0 0
Dual Incision in GG-NER R-HSA-5696400 3.182564e-01 0.497 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.880764e-01 0.411 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.220387e-01 0.375 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.220387e-01 0.375 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.682874e-01 0.329 0 0
Signaling by APC mutants R-HSA-4839744 4.682874e-01 0.329 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.682874e-01 0.329 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.682874e-01 0.329 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.682874e-01 0.329 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.131785e-01 0.384 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.544993e-01 0.594 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.048886e-01 0.393 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.048886e-01 0.393 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.664662e-01 0.436 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.832608e-01 0.417 0 0
PKA activation R-HSA-163615 4.801201e-01 0.319 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.801201e-01 0.319 0 0
PKA activation in glucagon signalling R-HSA-164378 4.801201e-01 0.319 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.081416e-01 0.389 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.366688e-01 0.360 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.262537e-01 0.370 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.169225e-01 0.380 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.337281e-01 0.363 0 0
Dual incision in TC-NER R-HSA-6782135 4.671428e-01 0.331 0 0
G0 and Early G1 R-HSA-1538133 2.607755e-01 0.584 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.202032e-01 0.377 0 0
Generation of second messenger molecules R-HSA-202433 4.366688e-01 0.360 0 0
HIV Transcription Elongation R-HSA-167169 4.366688e-01 0.360 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.182564e-01 0.497 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.366688e-01 0.360 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.562463e-01 0.341 0 0
Oncogene Induced Senescence R-HSA-2559585 3.378548e-01 0.471 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.963241e-01 0.528 0 0
G-protein activation R-HSA-202040 3.375528e-01 0.472 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.740208e-01 0.427 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.600659e-01 0.337 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.111286e-01 0.507 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.919817e-01 0.407 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.607755e-01 0.584 0 0
Regulation of CDH11 function R-HSA-9762292 4.308160e-01 0.366 0 0
PI3K/AKT activation R-HSA-198203 4.308160e-01 0.366 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.168880e-01 0.499 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.827671e-01 0.549 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.682874e-01 0.329 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.698187e-01 0.569 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.169668e-01 0.380 0 0
GPER1 signaling R-HSA-9634597 4.443003e-01 0.352 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.913586e-01 0.309 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.873099e-01 0.542 0 0
Proteasome assembly R-HSA-9907900 3.718684e-01 0.430 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.485610e-01 0.348 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.705272e-01 0.568 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.000900e-01 0.398 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.697860e-01 0.569 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.880764e-01 0.411 0 0
Signal amplification R-HSA-392518 4.913586e-01 0.309 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.625874e-01 0.581 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.525983e-01 0.598 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.267663e-01 0.486 0 0
Frs2-mediated activation R-HSA-170968 3.009020e-01 0.522 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.111286e-01 0.507 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.519933e-01 0.453 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.519933e-01 0.453 0 0
Nucleotide salvage defects R-HSA-9734207 3.519933e-01 0.453 0 0
mRNA Editing R-HSA-75072 3.919817e-01 0.407 0 0
Nuclear RNA decay R-HSA-9930044 2.796593e-01 0.553 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.308160e-01 0.366 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.988389e-01 0.525 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.828699e-01 0.417 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.513959e-01 0.345 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.562463e-01 0.341 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.504775e-01 0.346 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.726956e-01 0.564 0 0
Mismatch Repair R-HSA-5358508 2.625874e-01 0.581 0 0
Apoptotic factor-mediated response R-HSA-111471 2.625874e-01 0.581 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.608162e-01 0.443 0 0
Signaling by SCF-KIT R-HSA-1433557 3.537850e-01 0.451 0 0
Platelet degranulation R-HSA-114608 4.354232e-01 0.361 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.179283e-01 0.498 0 0
Circadian clock R-HSA-9909396 4.060723e-01 0.391 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.357911e-01 0.474 0 0
Selective autophagy R-HSA-9663891 4.134387e-01 0.384 0 0
FasL/ CD95L signaling R-HSA-75157 4.310471e-01 0.365 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.917441e-01 0.308 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.917441e-01 0.308 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.917441e-01 0.308 0 0
Polo-like kinase mediated events R-HSA-156711 4.801201e-01 0.319 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.317014e-01 0.365 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.963241e-01 0.528 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.485610e-01 0.348 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.697482e-01 0.569 0 0
Neurofascin interactions R-HSA-447043 2.697482e-01 0.569 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.519933e-01 0.453 0 0
Rap1 signalling R-HSA-392517 2.873099e-01 0.542 0 0
Autophagy R-HSA-9612973 4.072453e-01 0.390 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.485610e-01 0.348 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.618540e-01 0.582 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.919817e-01 0.407 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.168880e-01 0.499 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.366688e-01 0.360 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.131785e-01 0.384 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.986762e-01 0.399 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.213314e-01 0.493 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.619094e-01 0.441 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.220387e-01 0.375 0 0
Adipogenesis R-HSA-9843745 4.914284e-01 0.309 0 0
Cellular response to chemical stress R-HSA-9711123 2.893866e-01 0.539 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.900004e-01 0.409 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.179283e-01 0.498 0 0
Generic Transcription Pathway R-HSA-212436 3.400018e-01 0.469 0 0
Signaling by TGFB family members R-HSA-9006936 2.842515e-01 0.546 0 0
Mitophagy R-HSA-5205647 3.182564e-01 0.497 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.870568e-01 0.542 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.870568e-01 0.542 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.870568e-01 0.542 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.870568e-01 0.542 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.870568e-01 0.542 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.870568e-01 0.542 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.631060e-01 0.440 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.631060e-01 0.440 0 0
MET activates STAT3 R-HSA-8875791 4.310471e-01 0.365 0 0
Signaling by LTK R-HSA-9842663 2.705272e-01 0.568 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.519933e-01 0.453 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.009020e-01 0.522 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.917441e-01 0.308 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.917441e-01 0.308 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.308160e-01 0.366 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.308160e-01 0.366 0 0
Signaling by NOTCH2 R-HSA-1980145 3.182564e-01 0.497 0 0
Bicarbonate transporters R-HSA-425381 4.682874e-01 0.329 0 0
Degradation of CDH1 R-HSA-9766229 3.166136e-01 0.499 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.513959e-01 0.345 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.801201e-01 0.319 0 0
Signaling by FGFR2 R-HSA-5654738 4.074406e-01 0.390 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.867740e-01 0.313 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.638164e-01 0.334 0 0
Developmental Biology R-HSA-1266738 2.918313e-01 0.535 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.525983e-01 0.598 0 0
Signaling by PTK6 R-HSA-8848021 2.839661e-01 0.547 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.839661e-01 0.547 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.705272e-01 0.568 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.513959e-01 0.345 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.314293e-01 0.480 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.919817e-01 0.407 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.308160e-01 0.366 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.926528e-01 0.406 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.074406e-01 0.390 0 0
Nef and signal transduction R-HSA-164944 2.697482e-01 0.569 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.111286e-01 0.507 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.314293e-01 0.480 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.919817e-01 0.407 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.919817e-01 0.407 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.917441e-01 0.308 0 0
Syndecan interactions R-HSA-3000170 4.131785e-01 0.384 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.913586e-01 0.309 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.562463e-01 0.341 0 0
Signaling by FGFR in disease R-HSA-1226099 4.452436e-01 0.351 0 0
tRNA Aminoacylation R-HSA-379724 3.612086e-01 0.442 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.366688e-01 0.360 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.366688e-01 0.360 0 0
Other interleukin signaling R-HSA-449836 2.873099e-01 0.542 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.375528e-01 0.472 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.870568e-01 0.542 0 0
DSCAM interactions R-HSA-376172 3.631060e-01 0.440 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.631060e-01 0.440 0 0
Diseases of cellular response to stress R-HSA-9675132 3.631060e-01 0.440 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.697482e-01 0.569 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.310471e-01 0.365 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.519933e-01 0.453 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.919817e-01 0.407 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.917441e-01 0.308 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.619094e-01 0.441 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.796593e-01 0.553 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.796593e-01 0.553 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.921647e-01 0.407 0 0
Gluconeogenesis R-HSA-70263 4.443003e-01 0.352 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.697482e-01 0.569 0 0
Histamine receptors R-HSA-390650 4.310471e-01 0.365 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.919817e-01 0.407 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.308160e-01 0.366 0 0
Potential therapeutics for SARS R-HSA-9679191 2.694472e-01 0.570 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.111286e-01 0.507 0 0
Dopamine receptors R-HSA-390651 4.917441e-01 0.308 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.308160e-01 0.366 0 0
Ethanol oxidation R-HSA-71384 3.880764e-01 0.411 0 0
G1/S-Specific Transcription R-HSA-69205 3.575783e-01 0.447 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.951645e-01 0.530 0 0
MHC class II antigen presentation R-HSA-2132295 2.897500e-01 0.538 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.525983e-01 0.598 0 0
Neurodegenerative Diseases R-HSA-8863678 2.525983e-01 0.598 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.714554e-01 0.327 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.631060e-01 0.440 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.111286e-01 0.507 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.919817e-01 0.407 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.919817e-01 0.407 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.628345e-01 0.440 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.682874e-01 0.329 0 0
Interleukin-7 signaling R-HSA-1266695 4.626059e-01 0.335 0 0
Assembly Of The HIV Virion R-HSA-175474 3.628345e-01 0.440 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.756569e-01 0.323 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.308160e-01 0.366 0 0
Signaling by Interleukins R-HSA-449147 2.465416e-01 0.608 0 0
FLT3 Signaling R-HSA-9607240 4.562463e-01 0.341 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.995105e-01 0.398 0 0
IRE1alpha activates chaperones R-HSA-381070 2.555471e-01 0.593 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.799970e-01 0.553 0 0
Growth hormone receptor signaling R-HSA-982772 4.131785e-01 0.384 0 0
Selenoamino acid metabolism R-HSA-2408522 2.479204e-01 0.606 0 0
Regulation of beta-cell development R-HSA-186712 4.836972e-01 0.315 0 0
Formation of apoptosome R-HSA-111458 4.308160e-01 0.366 0 0
Cilium Assembly R-HSA-5617833 4.922717e-01 0.308 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.947345e-01 0.306 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.948610e-01 0.306 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.977070e-01 0.303 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.042449e-01 0.297 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.042449e-01 0.297 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.042449e-01 0.297 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.042449e-01 0.297 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.042449e-01 0.297 0 0
NF-kB is activated and signals survival R-HSA-209560 5.042449e-01 0.297 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.042449e-01 0.297 0 0
Signaling by AXIN mutants R-HSA-4839735 5.042449e-01 0.297 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.042449e-01 0.297 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.042449e-01 0.297 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.057618e-01 0.296 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.081140e-01 0.294 0 0
Specification of the neural plate border R-HSA-9834899 5.081140e-01 0.294 0 0
Translesion Synthesis by POLH R-HSA-110320 5.081140e-01 0.294 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.081140e-01 0.294 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.081140e-01 0.294 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.081140e-01 0.294 0 0
The NLRP3 inflammasome R-HSA-844456 5.081140e-01 0.294 0 0
TCR signaling R-HSA-202403 5.100538e-01 0.292 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.104877e-01 0.292 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.104877e-01 0.292 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.104877e-01 0.292 0 0
Regulation of Apoptosis R-HSA-169911 5.123009e-01 0.290 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.123009e-01 0.290 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.138219e-01 0.289 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.151609e-01 0.288 0 0
Developmental Cell Lineages R-HSA-9734767 5.181011e-01 0.286 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.184602e-01 0.285 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.204533e-01 0.284 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.323937e-01 0.274 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.324486e-01 0.274 0 0
Heme signaling R-HSA-9707616 5.324486e-01 0.274 0 0
Signaling by PDGF R-HSA-186797 5.324486e-01 0.274 0 0
G1 Phase R-HSA-69236 5.325060e-01 0.274 0 0
Cyclin D associated events in G1 R-HSA-69231 5.325060e-01 0.274 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.326156e-01 0.274 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.326156e-01 0.274 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.328797e-01 0.273 0 0
RUNX2 regulates bone development R-HSA-8941326 5.328797e-01 0.273 0 0
HIV elongation arrest and recovery R-HSA-167287 5.336894e-01 0.273 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.336894e-01 0.273 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.336894e-01 0.273 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.336894e-01 0.273 0 0
Formation of definitive endoderm R-HSA-9823730 5.352971e-01 0.271 0 0
Protein hydroxylation R-HSA-9629569 5.352971e-01 0.271 0 0
MET activates RAS signaling R-HSA-8851805 5.385851e-01 0.269 0 0
Leading Strand Synthesis R-HSA-69109 5.385851e-01 0.269 0 0
Polymerase switching R-HSA-69091 5.385851e-01 0.269 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.385851e-01 0.269 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.385851e-01 0.269 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.385851e-01 0.269 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.385851e-01 0.269 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.385851e-01 0.269 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.385851e-01 0.269 0 0
Regulation of IFNG signaling R-HSA-877312 5.385851e-01 0.269 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.385851e-01 0.269 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.385851e-01 0.269 0 0
Disorders of Nervous System Development R-HSA-9697154 5.385851e-01 0.269 0 0
Pervasive developmental disorders R-HSA-9005895 5.385851e-01 0.269 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.385851e-01 0.269 0 0
OAS antiviral response R-HSA-8983711 5.385851e-01 0.269 0 0
G2 Phase R-HSA-68911 5.459690e-01 0.263 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.459690e-01 0.263 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.459690e-01 0.263 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.459690e-01 0.263 0 0
Activation of AKT2 R-HSA-165158 5.459690e-01 0.263 0 0
Activation of C3 and C5 R-HSA-174577 5.459690e-01 0.263 0 0
Reelin signalling pathway R-HSA-8866376 5.459690e-01 0.263 0 0
Inositol transporters R-HSA-429593 5.459690e-01 0.263 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.459690e-01 0.263 0 0
NrCAM interactions R-HSA-447038 5.459690e-01 0.263 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.459690e-01 0.263 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.459690e-01 0.263 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.462676e-01 0.263 0 0
RSV-host interactions R-HSA-9833110 5.462852e-01 0.263 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.483200e-01 0.261 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.483200e-01 0.261 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.508824e-01 0.259 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.508824e-01 0.259 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.508824e-01 0.259 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.508824e-01 0.259 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.508824e-01 0.259 0 0
mRNA Capping R-HSA-72086 5.563293e-01 0.255 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.563293e-01 0.255 0 0
Glucagon-type ligand receptors R-HSA-420092 5.563293e-01 0.255 0 0
tRNA processing R-HSA-72306 5.567174e-01 0.254 0 0
Lagging Strand Synthesis R-HSA-69186 5.616048e-01 0.251 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.616048e-01 0.251 0 0
Signalling to RAS R-HSA-167044 5.616048e-01 0.251 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.616048e-01 0.251 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.616048e-01 0.251 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.616048e-01 0.251 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.616048e-01 0.251 0 0
G alpha (z) signalling events R-HSA-418597 5.660970e-01 0.247 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.683717e-01 0.245 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.689233e-01 0.245 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.712438e-01 0.243 0 0
Formation of axial mesoderm R-HSA-9796292 5.712438e-01 0.243 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.712438e-01 0.243 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.712438e-01 0.243 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.712438e-01 0.243 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.712438e-01 0.243 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.712438e-01 0.243 0 0
Signaling by FGFR R-HSA-190236 5.718895e-01 0.243 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.727973e-01 0.242 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.727973e-01 0.242 0 0
DAP12 signaling R-HSA-2424491 5.783653e-01 0.238 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.783653e-01 0.238 0 0
Cellular response to hypoxia R-HSA-1234174 5.793743e-01 0.237 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.866038e-01 0.232 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.866038e-01 0.232 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.869869e-01 0.231 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.869869e-01 0.231 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.869869e-01 0.231 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.920722e-01 0.228 0 0
Stabilization of p53 R-HSA-69541 5.920722e-01 0.228 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.920722e-01 0.228 0 0
Plus-strand DNA synthesis R-HSA-164525 5.944116e-01 0.226 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.944116e-01 0.226 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.944116e-01 0.226 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.944116e-01 0.226 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.944116e-01 0.226 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.944116e-01 0.226 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.944116e-01 0.226 0 0
Signaling by MAPK mutants R-HSA-9652817 5.944116e-01 0.226 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.944116e-01 0.226 0 0
Signaling by MST1 R-HSA-8852405 5.944116e-01 0.226 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.944116e-01 0.226 0 0
TRAIL signaling R-HSA-75158 5.944116e-01 0.226 0 0
PDE3B signalling R-HSA-165160 5.944116e-01 0.226 0 0
PKB-mediated events R-HSA-109703 5.944116e-01 0.226 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.944116e-01 0.226 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.944116e-01 0.226 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.944116e-01 0.226 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.944116e-01 0.226 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.947984e-01 0.226 0 0
Signaling by NTRKs R-HSA-166520 5.979580e-01 0.223 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.997622e-01 0.222 0 0
Budding and maturation of HIV virion R-HSA-162588 5.997622e-01 0.222 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.021889e-01 0.220 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.021889e-01 0.220 0 0
Physiological factors R-HSA-5578768 6.021889e-01 0.220 0 0
Malate-aspartate shuttle R-HSA-9856872 6.021889e-01 0.220 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.089388e-01 0.215 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.093978e-01 0.215 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.108559e-01 0.214 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.108559e-01 0.214 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.108559e-01 0.214 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.114060e-01 0.214 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.114060e-01 0.214 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.114060e-01 0.214 0 0
Signaling by KIT in disease R-HSA-9669938 6.114060e-01 0.214 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.204917e-01 0.207 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.207982e-01 0.207 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.207982e-01 0.207 0 0
Transcription of the HIV genome R-HSA-167172 6.239862e-01 0.205 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.291268e-01 0.201 0 0
Amino acid transport across the plasma membrane R-HSA-352230 6.298779e-01 0.201 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.314143e-01 0.200 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.314143e-01 0.200 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.314143e-01 0.200 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.314143e-01 0.200 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.314143e-01 0.200 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.314143e-01 0.200 0 0
DNA Damage Reversal R-HSA-73942 6.314143e-01 0.200 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.314143e-01 0.200 0 0
Biotin transport and metabolism R-HSA-196780 6.314143e-01 0.200 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.314143e-01 0.200 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.348364e-01 0.197 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.348364e-01 0.197 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.372761e-01 0.196 0 0
Azathioprine ADME R-HSA-9748787 6.372761e-01 0.196 0 0
Interleukin-1 family signaling R-HSA-446652 6.372923e-01 0.196 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.376881e-01 0.195 0 0
Uncoating of the HIV Virion R-HSA-162585 6.376881e-01 0.195 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.376881e-01 0.195 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.376881e-01 0.195 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.376881e-01 0.195 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.376881e-01 0.195 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.376881e-01 0.195 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.376881e-01 0.195 0 0
MET Receptor Activation R-HSA-6806942 6.376881e-01 0.195 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.376881e-01 0.195 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.376881e-01 0.195 0 0
Lactose synthesis R-HSA-5653890 6.376881e-01 0.195 0 0
CREB phosphorylation R-HSA-199920 6.376881e-01 0.195 0 0
Metabolism of vitamin K R-HSA-6806664 6.376881e-01 0.195 0 0
HDL clearance R-HSA-8964011 6.376881e-01 0.195 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.405317e-01 0.193 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.461150e-01 0.190 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.468674e-01 0.189 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.468674e-01 0.189 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.468674e-01 0.189 0 0
HIV Transcription Initiation R-HSA-167161 6.468674e-01 0.189 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.468674e-01 0.189 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.468674e-01 0.189 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.468674e-01 0.189 0 0
Immune System R-HSA-168256 6.538672e-01 0.185 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.572627e-01 0.182 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.572627e-01 0.182 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.572627e-01 0.182 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.589346e-01 0.181 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.589346e-01 0.181 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.589346e-01 0.181 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.589346e-01 0.181 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.589346e-01 0.181 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.589346e-01 0.181 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.589346e-01 0.181 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.589346e-01 0.181 0 0
Negative regulation of FLT3 R-HSA-9706369 6.589346e-01 0.181 0 0
Aquaporin-mediated transport R-HSA-445717 6.596976e-01 0.181 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.596976e-01 0.181 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.598658e-01 0.181 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.604511e-01 0.180 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.604511e-01 0.180 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.640636e-01 0.178 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.640636e-01 0.178 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.670667e-01 0.176 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.689231e-01 0.175 0 0
Hemostasis R-HSA-109582 6.730630e-01 0.172 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.740483e-01 0.171 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.763493e-01 0.170 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.763493e-01 0.170 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.763493e-01 0.170 0 0
PTK6 Expression R-HSA-8849473 6.763493e-01 0.170 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.763493e-01 0.170 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.763493e-01 0.170 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.763493e-01 0.170 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.763493e-01 0.170 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.763493e-01 0.170 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.763493e-01 0.170 0 0
Maturation of replicase proteins R-HSA-9694301 6.763493e-01 0.170 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.784828e-01 0.168 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.784828e-01 0.168 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.784828e-01 0.168 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.784828e-01 0.168 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.786784e-01 0.168 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.786784e-01 0.168 0 0
G protein gated Potassium channels R-HSA-1296059 6.786784e-01 0.168 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.786784e-01 0.168 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.807049e-01 0.167 0 0
Signaling by FGFR4 R-HSA-5654743 6.807049e-01 0.167 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.807049e-01 0.167 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.847810e-01 0.164 0 0
Glycine degradation R-HSA-6783984 6.847810e-01 0.164 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.847810e-01 0.164 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.847810e-01 0.164 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.847810e-01 0.164 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.963765e-01 0.157 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.963765e-01 0.157 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.967838e-01 0.157 0 0
Amine ligand-binding receptors R-HSA-375280 6.967838e-01 0.157 0 0
MET activates PTK2 signaling R-HSA-8874081 6.990849e-01 0.155 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.990849e-01 0.155 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.990849e-01 0.155 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.990849e-01 0.155 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.990849e-01 0.155 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.999802e-01 0.155 0 0
Macroautophagy R-HSA-1632852 6.999802e-01 0.155 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.015921e-01 0.154 0 0
Signaling by ERBB4 R-HSA-1236394 7.049134e-01 0.152 0 0
Adaptive Immune System R-HSA-1280218 7.055479e-01 0.151 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.089972e-01 0.149 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.108871e-01 0.148 0 0
Minus-strand DNA synthesis R-HSA-164516 7.108871e-01 0.148 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.108871e-01 0.148 0 0
RSK activation R-HSA-444257 7.108871e-01 0.148 0 0
phospho-PLA2 pathway R-HSA-111995 7.108871e-01 0.148 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.108871e-01 0.148 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.108871e-01 0.148 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.108871e-01 0.148 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.108871e-01 0.148 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.108871e-01 0.148 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.108871e-01 0.148 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.108871e-01 0.148 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.108871e-01 0.148 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.108871e-01 0.148 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.108871e-01 0.148 0 0
Sodium/Proton exchangers R-HSA-425986 7.108871e-01 0.148 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.108871e-01 0.148 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.108871e-01 0.148 0 0
Alpha-defensins R-HSA-1462054 7.108871e-01 0.148 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.122957e-01 0.147 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.122957e-01 0.147 0 0
Signaling by FGFR3 R-HSA-5654741 7.122957e-01 0.147 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.122957e-01 0.147 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.129821e-01 0.147 0 0
GPVI-mediated activation cascade R-HSA-114604 7.135449e-01 0.147 0 0
Interleukin-1 signaling R-HSA-9020702 7.161160e-01 0.145 0 0
Cristae formation R-HSA-8949613 7.184904e-01 0.144 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.184904e-01 0.144 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.184904e-01 0.144 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.199872e-01 0.143 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.199872e-01 0.143 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.201020e-01 0.143 0 0
Signaling by FGFR1 R-HSA-5654736 7.267367e-01 0.139 0 0
Ion homeostasis R-HSA-5578775 7.267367e-01 0.139 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.295293e-01 0.137 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.299899e-01 0.137 0 0
Metabolism of folate and pterines R-HSA-196757 7.299899e-01 0.137 0 0
Degradation of DVL R-HSA-4641258 7.299899e-01 0.137 0 0
Degradation of AXIN R-HSA-4641257 7.299899e-01 0.137 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.299899e-01 0.137 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.316368e-01 0.136 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.316368e-01 0.136 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.316368e-01 0.136 0 0
Platelet sensitization by LDL R-HSA-432142 7.316368e-01 0.136 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.316368e-01 0.136 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.316368e-01 0.136 0 0
Nephron development R-HSA-9831926 7.316368e-01 0.136 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.333325e-01 0.135 0 0
Telomere Extension By Telomerase R-HSA-171319 7.369091e-01 0.133 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.369091e-01 0.133 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.369091e-01 0.133 0 0
Inflammasomes R-HSA-622312 7.369091e-01 0.133 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.369091e-01 0.133 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.417411e-01 0.130 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.417411e-01 0.130 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.417411e-01 0.130 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.417411e-01 0.130 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.417411e-01 0.130 0 0
Calcineurin activates NFAT R-HSA-2025928 7.417411e-01 0.130 0 0
WNT mediated activation of DVL R-HSA-201688 7.417411e-01 0.130 0 0
Interleukin-1 processing R-HSA-448706 7.417411e-01 0.130 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.417411e-01 0.130 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.417411e-01 0.130 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.417411e-01 0.130 0 0
PCP/CE pathway R-HSA-4086400 7.521022e-01 0.124 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.527604e-01 0.123 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.527604e-01 0.123 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.527604e-01 0.123 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.543597e-01 0.122 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.543597e-01 0.122 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.543597e-01 0.122 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.554239e-01 0.122 0 0
Signaling by ALK R-HSA-201556 7.607344e-01 0.119 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.607344e-01 0.119 0 0
Extension of Telomeres R-HSA-180786 7.651882e-01 0.116 0 0
Gap junction trafficking and regulation R-HSA-157858 7.686735e-01 0.114 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.690985e-01 0.114 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.693040e-01 0.114 0 0
DNA replication initiation R-HSA-68952 7.693040e-01 0.114 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.693040e-01 0.114 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.693040e-01 0.114 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.693040e-01 0.114 0 0
Pexophagy R-HSA-9664873 7.693040e-01 0.114 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.693040e-01 0.114 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.708654e-01 0.113 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.708654e-01 0.113 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.708654e-01 0.113 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.708654e-01 0.113 0 0
Signaling by NODAL R-HSA-1181150 7.724337e-01 0.112 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.724337e-01 0.112 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.724337e-01 0.112 0 0
Creatine metabolism R-HSA-71288 7.724337e-01 0.112 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.746976e-01 0.111 0 0
Aggrephagy R-HSA-9646399 7.750536e-01 0.111 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.770745e-01 0.110 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.813695e-01 0.107 0 0
Hedgehog 'on' state R-HSA-5632684 7.854889e-01 0.105 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.864523e-01 0.104 0 0
Infectious disease R-HSA-5663205 7.884712e-01 0.103 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.885023e-01 0.103 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.886878e-01 0.103 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.907256e-01 0.102 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.935202e-01 0.100 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.939266e-01 0.100 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.939266e-01 0.100 0 0
vRNA Synthesis R-HSA-192814 7.939266e-01 0.100 0 0
vRNP Assembly R-HSA-192905 7.939266e-01 0.100 0 0
Synthesis of PI R-HSA-1483226 7.939266e-01 0.100 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 7.939266e-01 0.100 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.939266e-01 0.100 0 0
Suppression of apoptosis R-HSA-9635465 7.939266e-01 0.100 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.939266e-01 0.100 0 0
Prostanoid ligand receptors R-HSA-391908 7.939266e-01 0.100 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.939266e-01 0.100 0 0
Post-translational protein modification R-HSA-597592 7.991168e-01 0.097 0 0
Hedgehog 'off' state R-HSA-5610787 8.008622e-01 0.096 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.011495e-01 0.096 0 0
Intra-Golgi traffic R-HSA-6811438 8.016525e-01 0.096 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.032626e-01 0.095 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.077068e-01 0.093 0 0
Attachment and Entry R-HSA-9694614 8.077068e-01 0.093 0 0
Serine metabolism R-HSA-977347 8.077068e-01 0.093 0 0
Activation of GABAB receptors R-HSA-991365 8.139648e-01 0.089 0 0
GABA B receptor activation R-HSA-977444 8.139648e-01 0.089 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.149879e-01 0.089 0 0
DS-GAG biosynthesis R-HSA-2022923 8.159225e-01 0.088 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.159225e-01 0.088 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.159225e-01 0.088 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.159225e-01 0.088 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.159225e-01 0.088 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.159225e-01 0.088 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.162261e-01 0.088 0 0
Integration of energy metabolism R-HSA-163685 8.166380e-01 0.088 0 0
IGF1R signaling cascade R-HSA-2428924 8.200986e-01 0.086 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.234487e-01 0.084 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.234487e-01 0.084 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.234487e-01 0.084 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.234487e-01 0.084 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.234487e-01 0.084 0 0
Cellular hexose transport R-HSA-189200 8.234487e-01 0.084 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.234487e-01 0.084 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.272299e-01 0.082 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.280000e-01 0.082 0 0
Metabolism of proteins R-HSA-392499 8.296068e-01 0.081 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.297611e-01 0.081 0 0
Signaling by Hedgehog R-HSA-5358351 8.302305e-01 0.081 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.315366e-01 0.080 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.355718e-01 0.078 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.355718e-01 0.078 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.355718e-01 0.078 0 0
Repression of WNT target genes R-HSA-4641265 8.355718e-01 0.078 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.355718e-01 0.078 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.355718e-01 0.078 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.355718e-01 0.078 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.355718e-01 0.078 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.355718e-01 0.078 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.355718e-01 0.078 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.355718e-01 0.078 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.355718e-01 0.078 0 0
Synthesis of GDP-mannose R-HSA-446205 8.355718e-01 0.078 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.355718e-01 0.078 0 0
Interleukin-15 signaling R-HSA-8983432 8.355718e-01 0.078 0 0
DAP12 interactions R-HSA-2172127 8.367069e-01 0.077 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.367122e-01 0.077 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.380222e-01 0.077 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.380222e-01 0.077 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.390038e-01 0.076 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.402193e-01 0.076 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.402193e-01 0.076 0 0
eNOS activation R-HSA-203615 8.402193e-01 0.076 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.402193e-01 0.076 0 0
RA biosynthesis pathway R-HSA-5365859 8.402193e-01 0.076 0 0
Gastrulation R-HSA-9758941 8.428487e-01 0.074 0 0
Parasite infection R-HSA-9664407 8.430541e-01 0.074 0 0
Leishmania phagocytosis R-HSA-9664417 8.430541e-01 0.074 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.430541e-01 0.074 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.464758e-01 0.072 0 0
Somitogenesis R-HSA-9824272 8.471766e-01 0.072 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.514974e-01 0.070 0 0
Complex III assembly R-HSA-9865881 8.514974e-01 0.070 0 0
PERK regulates gene expression R-HSA-381042 8.516802e-01 0.070 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.531246e-01 0.069 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.531246e-01 0.069 0 0
Processing of SMDT1 R-HSA-8949664 8.531246e-01 0.069 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.531246e-01 0.069 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.531246e-01 0.069 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.531246e-01 0.069 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.531246e-01 0.069 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.531246e-01 0.069 0 0
Maturation of nucleoprotein R-HSA-9683610 8.531246e-01 0.069 0 0
Interleukin-6 signaling R-HSA-1059683 8.531246e-01 0.069 0 0
IRS-mediated signalling R-HSA-112399 8.555971e-01 0.068 0 0
Regulated Necrosis R-HSA-5218859 8.562704e-01 0.067 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.570734e-01 0.067 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.596118e-01 0.066 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.602080e-01 0.065 0 0
ER-Phagosome pathway R-HSA-1236974 8.609084e-01 0.065 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.624171e-01 0.064 0 0
RNA Polymerase III Transcription R-HSA-74158 8.624171e-01 0.064 0 0
Glycosphingolipid transport R-HSA-9845576 8.624171e-01 0.064 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.624171e-01 0.064 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.639426e-01 0.064 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.639426e-01 0.064 0 0
Tight junction interactions R-HSA-420029 8.639426e-01 0.064 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.639426e-01 0.064 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.639426e-01 0.064 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.640747e-01 0.063 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.640747e-01 0.063 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.640747e-01 0.063 0 0
Regulation of insulin secretion R-HSA-422356 8.640747e-01 0.063 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.688046e-01 0.061 0 0
Removal of the Flap Intermediate R-HSA-69166 8.688046e-01 0.061 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.688046e-01 0.061 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.688046e-01 0.061 0 0
Hydrolysis of LPC R-HSA-1483115 8.688046e-01 0.061 0 0
cGMP effects R-HSA-418457 8.688046e-01 0.061 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.688046e-01 0.061 0 0
Prolactin receptor signaling R-HSA-1170546 8.688046e-01 0.061 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.688046e-01 0.061 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.688046e-01 0.061 0 0
Zinc transporters R-HSA-435354 8.688046e-01 0.061 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.698445e-01 0.061 0 0
Mitochondrial biogenesis R-HSA-1592230 8.711173e-01 0.060 0 0
COPII-mediated vesicle transport R-HSA-204005 8.719840e-01 0.059 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.719840e-01 0.059 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.728616e-01 0.059 0 0
NGF-stimulated transcription R-HSA-9031628 8.752340e-01 0.058 0 0
Myogenesis R-HSA-525793 8.754241e-01 0.058 0 0
TRP channels R-HSA-3295583 8.754241e-01 0.058 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.754241e-01 0.058 0 0
Sphingolipid catabolism R-HSA-9845614 8.754241e-01 0.058 0 0
ABC-family proteins mediated transport R-HSA-382556 8.769216e-01 0.057 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.784825e-01 0.056 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.818568e-01 0.055 0 0
Elastic fibre formation R-HSA-1566948 8.818568e-01 0.055 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.818568e-01 0.055 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.828115e-01 0.054 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.828115e-01 0.054 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.828115e-01 0.054 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.828115e-01 0.054 0 0
Translesion synthesis by REV1 R-HSA-110312 8.828115e-01 0.054 0 0
Protein lipoylation R-HSA-9857492 8.828115e-01 0.054 0 0
Signaling by Activin R-HSA-1502540 8.828115e-01 0.054 0 0
p38MAPK events R-HSA-171007 8.828115e-01 0.054 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.828115e-01 0.054 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.828115e-01 0.054 0 0
Other semaphorin interactions R-HSA-416700 8.828115e-01 0.054 0 0
Formation of the anterior neural plate R-HSA-9823739 8.828115e-01 0.054 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.835416e-01 0.054 0 0
SLC transporter disorders R-HSA-5619102 8.848028e-01 0.053 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.860059e-01 0.053 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.860059e-01 0.053 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.860059e-01 0.053 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.860059e-01 0.053 0 0
MAP kinase activation R-HSA-450294 8.876671e-01 0.052 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.876671e-01 0.052 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.906277e-01 0.050 0 0
PI3K Cascade R-HSA-109704 8.913631e-01 0.050 0 0
Ca2+ pathway R-HSA-4086398 8.928428e-01 0.049 0 0
Translesion synthesis by POLI R-HSA-5656121 8.953237e-01 0.048 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.953237e-01 0.048 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.953237e-01 0.048 0 0
Activation of SMO R-HSA-5635838 8.953237e-01 0.048 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.953237e-01 0.048 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 8.953237e-01 0.048 0 0
Attachment and Entry R-HSA-9678110 8.953237e-01 0.048 0 0
The phototransduction cascade R-HSA-2514856 8.987203e-01 0.046 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.987203e-01 0.046 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.988103e-01 0.046 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.040809e-01 0.044 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.047119e-01 0.043 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.047119e-01 0.043 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.047119e-01 0.043 0 0
DARPP-32 events R-HSA-180024 9.047119e-01 0.043 0 0
Iron uptake and transport R-HSA-917937 9.050788e-01 0.043 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.056346e-01 0.043 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.064371e-01 0.043 0 0
Translesion synthesis by POLK R-HSA-5655862 9.065006e-01 0.043 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.065006e-01 0.043 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.065006e-01 0.043 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.065006e-01 0.043 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.065006e-01 0.043 0 0
Heme assimilation R-HSA-9927020 9.065006e-01 0.043 0 0
Passive transport by Aquaporins R-HSA-432047 9.065006e-01 0.043 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.070410e-01 0.042 0 0
Insulin receptor signalling cascade R-HSA-74751 9.075171e-01 0.042 0 0
Ion transport by P-type ATPases R-HSA-936837 9.075171e-01 0.042 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.129501e-01 0.040 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.135393e-01 0.039 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.135393e-01 0.039 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.164846e-01 0.038 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.164846e-01 0.038 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.164846e-01 0.038 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.164846e-01 0.038 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.164846e-01 0.038 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.164846e-01 0.038 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.164846e-01 0.038 0 0
Catecholamine biosynthesis R-HSA-209905 9.164846e-01 0.038 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.164846e-01 0.038 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.164846e-01 0.038 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.164846e-01 0.038 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.205161e-01 0.036 0 0
ABC transporter disorders R-HSA-5619084 9.211663e-01 0.036 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.229935e-01 0.035 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.229935e-01 0.035 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.254031e-01 0.034 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.254031e-01 0.034 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.254031e-01 0.034 0 0
Tie2 Signaling R-HSA-210993 9.254031e-01 0.034 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.254031e-01 0.034 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.254031e-01 0.034 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.254031e-01 0.034 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.254031e-01 0.034 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.262908e-01 0.033 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.270588e-01 0.033 0 0
FOXO-mediated transcription R-HSA-9614085 9.274385e-01 0.033 0 0
Signaling by WNT in cancer R-HSA-4791275 9.274595e-01 0.033 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.274595e-01 0.033 0 0
Downstream TCR signaling R-HSA-202424 9.285079e-01 0.032 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.309160e-01 0.031 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.309160e-01 0.031 0 0
Gap junction trafficking R-HSA-190828 9.319975e-01 0.031 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.333697e-01 0.030 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.333697e-01 0.030 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.333697e-01 0.030 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.333697e-01 0.030 0 0
Maturation of nucleoprotein R-HSA-9694631 9.333697e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.333697e-01 0.030 0 0
Interferon gamma signaling R-HSA-877300 9.338603e-01 0.030 0 0
Interleukin-17 signaling R-HSA-448424 9.382040e-01 0.028 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.387726e-01 0.027 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.389694e-01 0.027 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.389694e-01 0.027 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.396623e-01 0.027 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.396623e-01 0.027 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.403034e-01 0.027 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.404859e-01 0.027 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.404859e-01 0.027 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.404859e-01 0.027 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.404859e-01 0.027 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.404859e-01 0.027 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.404859e-01 0.027 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.404859e-01 0.027 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.404859e-01 0.027 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.411200e-01 0.026 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.411200e-01 0.026 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.415201e-01 0.026 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.422080e-01 0.026 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.422080e-01 0.026 0 0
ECM proteoglycans R-HSA-3000178 9.423200e-01 0.026 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.461872e-01 0.024 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.461872e-01 0.024 0 0
Synthesis of PC R-HSA-1483191 9.467621e-01 0.024 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.468424e-01 0.024 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.468424e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.468424e-01 0.024 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.468424e-01 0.024 0 0
ERK/MAPK targets R-HSA-198753 9.468424e-01 0.024 0 0
Abacavir metabolism R-HSA-2161541 9.468424e-01 0.024 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.468424e-01 0.024 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.468424e-01 0.024 0 0
GABA receptor activation R-HSA-977443 9.474363e-01 0.023 0 0
Metabolism of polyamines R-HSA-351202 9.474363e-01 0.023 0 0
Neuronal System R-HSA-112316 9.484607e-01 0.023 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.490419e-01 0.023 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.498977e-01 0.022 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.498977e-01 0.022 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.498977e-01 0.022 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.498977e-01 0.022 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.506541e-01 0.022 0 0
CS-GAG biosynthesis R-HSA-2022870 9.525203e-01 0.021 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.525203e-01 0.021 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.525203e-01 0.021 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.525203e-01 0.021 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.525203e-01 0.021 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.525203e-01 0.021 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.525203e-01 0.021 0 0
Glutathione synthesis and recycling R-HSA-174403 9.525203e-01 0.021 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.525203e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.525203e-01 0.021 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.543719e-01 0.020 0 0
Mitochondrial protein import R-HSA-1268020 9.548137e-01 0.020 0 0
Transmission across Chemical Synapses R-HSA-112315 9.561422e-01 0.019 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.575921e-01 0.019 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.575921e-01 0.019 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.575921e-01 0.019 0 0
LDL clearance R-HSA-8964038 9.575921e-01 0.019 0 0
Neddylation R-HSA-8951664 9.596010e-01 0.018 0 0
Stimuli-sensing channels R-HSA-2672351 9.597743e-01 0.018 0 0
Toll-like Receptor Cascades R-HSA-168898 9.616157e-01 0.017 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.621224e-01 0.017 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.621224e-01 0.017 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.621224e-01 0.017 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.621224e-01 0.017 0 0
Carnitine shuttle R-HSA-200425 9.621224e-01 0.017 0 0
Purine salvage R-HSA-74217 9.621999e-01 0.017 0 0
G alpha (s) signalling events R-HSA-418555 9.648399e-01 0.016 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.648450e-01 0.016 0 0
Integrin cell surface interactions R-HSA-216083 9.648450e-01 0.016 0 0
Pentose phosphate pathway R-HSA-71336 9.656132e-01 0.015 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.656132e-01 0.015 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.661689e-01 0.015 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.661689e-01 0.015 0 0
Interleukin-6 family signaling R-HSA-6783589 9.661689e-01 0.015 0 0
Neurotransmitter release cycle R-HSA-112310 9.663966e-01 0.015 0 0
Nucleotide biosynthesis R-HSA-8956320 9.677707e-01 0.014 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.687289e-01 0.014 0 0
Diseases of Immune System R-HSA-5260271 9.687289e-01 0.014 0 0
Glycogen metabolism R-HSA-8982491 9.687289e-01 0.014 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.687289e-01 0.014 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.697834e-01 0.013 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.697834e-01 0.013 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.697834e-01 0.013 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.697834e-01 0.013 0 0
Laminin interactions R-HSA-3000157 9.697834e-01 0.013 0 0
Parasitic Infection Pathways R-HSA-9824443 9.703074e-01 0.013 0 0
Leishmania infection R-HSA-9658195 9.703074e-01 0.013 0 0
Formation of the cornified envelope R-HSA-6809371 9.726423e-01 0.012 0 0
Signaling by Insulin receptor R-HSA-74752 9.726727e-01 0.012 0 0
Urea cycle R-HSA-70635 9.730119e-01 0.012 0 0
Abacavir ADME R-HSA-2161522 9.730119e-01 0.012 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.730119e-01 0.012 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.741640e-01 0.011 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.741640e-01 0.011 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.745118e-01 0.011 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.756237e-01 0.011 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.758956e-01 0.011 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.758956e-01 0.011 0 0
Triglyceride biosynthesis R-HSA-75109 9.758956e-01 0.011 0 0
Synthesis of PE R-HSA-1483213 9.758956e-01 0.011 0 0
Insulin processing R-HSA-264876 9.758956e-01 0.011 0 0
Mitochondrial protein degradation R-HSA-9837999 9.762359e-01 0.010 0 0
Interferon alpha/beta signaling R-HSA-909733 9.770980e-01 0.010 0 0
Dectin-2 family R-HSA-5621480 9.771221e-01 0.010 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.774979e-01 0.010 0 0
Disease R-HSA-1643685 9.777319e-01 0.010 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.784713e-01 0.009 0 0
Insulin receptor recycling R-HSA-77387 9.784713e-01 0.009 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.784713e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.784713e-01 0.009 0 0
Pyrimidine salvage R-HSA-73614 9.784713e-01 0.009 0 0
Pyroptosis R-HSA-5620971 9.784713e-01 0.009 0 0
Innate Immune System R-HSA-168249 9.797859e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.807670e-01 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.807720e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.807720e-01 0.008 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.823745e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.828269e-01 0.008 0 0
Nucleotide salvage R-HSA-8956321 9.838531e-01 0.007 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.852125e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.859010e-01 0.006 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.862064e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.863016e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.863675e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.864676e-01 0.006 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.866891e-01 0.006 0 0
Intraflagellar transport R-HSA-5620924 9.868767e-01 0.006 0 0
Metal ion SLC transporters R-HSA-425410 9.868767e-01 0.006 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.872923e-01 0.006 0 0
PI Metabolism R-HSA-1483255 9.875448e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.877658e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.877658e-01 0.005 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.880996e-01 0.005 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.890736e-01 0.005 0 0
CS/DS degradation R-HSA-2024101 9.890736e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.890736e-01 0.005 0 0
Heme degradation R-HSA-189483 9.890736e-01 0.005 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.902416e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.902416e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.902416e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.902416e-01 0.004 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.902416e-01 0.004 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.911383e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.912849e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.913988e-01 0.004 0 0
HS-GAG biosynthesis R-HSA-2022928 9.922167e-01 0.003 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.922167e-01 0.003 0 0
Protein localization R-HSA-9609507 9.926921e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.928820e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.930489e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.930489e-01 0.003 0 0
Cardiac conduction R-HSA-5576891 9.931401e-01 0.003 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.933879e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.933879e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.934140e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.935831e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.939188e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.940078e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.943711e-01 0.002 0 0
Interleukin-2 family signaling R-HSA-451927 9.950488e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.954086e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.955783e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.955783e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.959998e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.960512e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.963815e-01 0.002 0 0
Defensins R-HSA-1461973 9.968508e-01 0.001 0 0
Methylation R-HSA-156581 9.971877e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.971877e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.972362e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.973242e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.974885e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.976539e-01 0.001 0 0
Kidney development R-HSA-9830369 9.980242e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.982147e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.982220e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.982220e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.984028e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.985653e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.987264e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.987264e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.988352e-01 0.001 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.991902e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.992254e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.992769e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9694635 9.992876e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.993543e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.994851e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.994851e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.994851e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.995403e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996409e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996727e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997564e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997755e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998143e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998519e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998678e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998678e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998678e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998767e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998775e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998794e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998820e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998886e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998897e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998914e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998946e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999059e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999274e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999274e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999316e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999412e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999442e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999452e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999466e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999508e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999574e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999693e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999697e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999759e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999808e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999814e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999828e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999834e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999844e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999866e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999869e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999902e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999927e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999931e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999938e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999943e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999944e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999959e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999963e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999975e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999976e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999986e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999987e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999988e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999994e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999994e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999996e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999997e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways