SGK3
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A4FU28 | S140 | Sugiyama | CTAGE9 | AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH |
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| O00231 | S298 | Sugiyama | PSMD11 | RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI |
| O00458 | S14 | Sugiyama | IFRD1 | _______MPKNKKRNtPHRGssAGGGGsGAAAATAATAGGQ |
| O00468 | S738 | Sugiyama | AGRN AGRIN | CGSDGVTYSTECELKKARCEsQRGLYVAAQGACRGPTFAPL |
| O14617 | S658 | Sugiyama | AP3D1 PRO0039 | DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN |
| O14618 | S267 | Sugiyama | CCS | DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________ |
| O14974 | S910 | Sugiyama | PPP1R12A MBS MYPT1 | yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST |
| O15067 | S1053 | Sugiyama | PFAS KIAA0361 | RGLRERMGPSYCLPPTFPKAsVPREPGGPsPRVAILREEGS |
| O15143 | S328 | Sugiyama | ARPC1B ARC41 | KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT |
| O15212 | T107 | Sugiyama | PFDN6 HKE2 PFD6 | IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG |
| O15226 | S618 | Sugiyama | NKRF ITBA4 NRF | VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ |
| O15357 | S43 | Sugiyama | INPPL1 SHIP2 | HRDLSRAAAEELLARAGRDGsFLVRDSESVAGAFALCVLYQ |
| O15400 | S126 | GPS6 | STX7 | KVQRQAAEREKEFVARVRAssRVsGsFPEDSsKERNLVsWE |
| O15530 | S176 | Sugiyama | PDPK1 PDK1 | YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL |
| O43175 | T78 | Sugiyama | PHGDH PGDH3 | KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT |
| O43318 | S439 | Sugiyama | MAP3K7 TAK1 | GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss |
| O43390 | S428 | Sugiyama | HNRNPR HNRPR | LAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRG |
| O43390 | T429 | Sugiyama | HNRNPR HNRPR | AKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRGR |
| O43390 | Y431 | Sugiyama | HNRNPR HNRPR | PPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRGRGR |
| O43524 | S253 | SIGNOR | FOXO3 FKHRL1 FOXO3A | WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA |
| O43707 | T69 | Sugiyama | ACTN4 | EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE |
| O43823 | S125 | Sugiyama | AKAP8 AKAP95 | KEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHNP |
| O43847 | S94 | Sugiyama | NRDC NRD1 | ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR |
| O60220 | S94 | Sugiyama | TIMM8A DDP DDP1 TIM8A | SQFILNRLEQTQKSKPVFSEsLsD_________________ |
| O60293 | S42 | Sugiyama | ZFC3H1 CCDC131 KIAA0546 PSRC2 | LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR |
| O60343 | S754 | Sugiyama | TBC1D4 AS160 KIAA0603 | QDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQ |
| O60343 | T749 | Sugiyama | TBC1D4 AS160 KIAA0603 | ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR |
| O60716 | S861 | Sugiyama | CTNND1 KIAA0384 | KEGWKKsDFQVNLNNAsRsQssHsyDDstLPLIDRNQKsDK |
| O60739 | T46 | Sugiyama | EIF1B | GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK |
| O60814 | S37 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| O60814 | S39 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| O60841 | S107 | Sugiyama | EIF5B IF2 KIAA0741 | NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA |
| O60841 | S182 | Sugiyama | EIF5B IF2 KIAA0741 | DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK |
| O60841 | S183 | Sugiyama | EIF5B IF2 KIAA0741 | GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN |
| O60841 | S186 | Sugiyama | EIF5B IF2 KIAA0741 | EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN |
| O75348 | S68 | Sugiyama | ATP6V1G1 ATP6G ATP6G1 ATP6J | RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF |
| O75369 | S1442 | Sugiyama | FLNB FLN1L FLN3 TABP TAP | SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP |
| O75369 | S2532 | Sugiyama | FLNB FLN1L FLN3 TABP TAP | ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP |
| O75390 | S453 | Sugiyama | CS | LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______ |
| O75494 | S133 | Sugiyama | SRSF10 FUSIP1 FUSIP2 SFRS13A TASR | yDRYRRSRSRSYERRRsRsRsFDyNYRRsYsPRNSRPTGRP |
| O75534 | S584 | Sugiyama | CSDE1 D1S155E KIAA0885 NRU UNR | YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP |
| O75665 | S899 | Sugiyama | OFD1 CXorf5 | EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER |
| O75821 | S217 | Sugiyama | EIF3G EIF3S4 | PGELEPVQAtQNKtGKYVPPsLRDGAsRRGESMQPNRRADD |
| O75821 | S223 | Sugiyama | EIF3G EIF3S4 | VQAtQNKtGKYVPPsLRDGAsRRGESMQPNRRADDNAtIRV |
| O94776 | S433 | Sugiyama | MTA2 MTA1L1 PID | ATRGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQt |
| O94888 | S280 | Sugiyama | UBXN7 KIAA0794 UBXD7 | EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE |
| O95155 | S105 | Sugiyama | UBE4B HDNB1 KIAA0684 UFD2 | LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG |
| O95218 | S181 | Sugiyama | ZRANB2 ZIS ZNF265 | DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR |
| O95243 | S318 | Sugiyama | MBD4 MED1 | ETLSVTSEENSLVKKKERsLssGsNFCSEQKTSGIINKFCS |
| O95785 | S1094 | Sugiyama | WIZ ZNF803 | WYVNGsPIDTLREILKRRTQsRPGGPPNPPGPsPKALAKMM |
| P00338 | S161 | Sugiyama | LDHA PIG19 | DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH |
| P00491 | S163 | Sugiyama | PNP NP | GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE |
| P00491 | S176 | Sugiyama | PNP NP | GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA |
| P00558 | S174 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL |
| P00558 | S175 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN |
| P00558 | S393 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA |
| P00558 | T369 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | ARGTKALMDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKV |
| P00558 | T376 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG |
| P00558 | T394 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL |
| P01023 | S273 | Sugiyama | A2M CPAMD5 FWP007 | LYTYGKPVPGHVTVSICRKYsDAsDCHGEDSQAFCEKFSGQ |
| P01893 | T264 | Sugiyama | HLA-H HLAH | DGEDQTQDTELVETRPAGDGtFQKWAAVVVPSGEEQRYTCH |
| P04040 | S517 | Sugiyama | CAT | LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________ |
| P04040 | T434 | Sugiyama | CAT | QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE |
| P04040 | T511 | Sugiyama | CAT | SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____ |
| P04075 | S176 | Sugiyama | ALDOA ALDA | EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD |
| P04075 | S336 | Sugiyama | ALDOA ALDA | GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04075 | S46 | Sugiyama | ALDOA ALDA | PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA |
| P04075 | T49 | Sugiyama | ALDOA ALDA | GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04406 | T237 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD |
| P04792 | S187 | Sugiyama | HSPB1 HSP27 HSP28 | APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__ |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05023 | S519 | Sugiyama | ATP1A1 | sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ |
| P05023 | S520 | Sugiyama | ATP1A1 | EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN |
| P05362 | S43 | Sugiyama | ICAM1 | GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP |
| P05783 | S93 | Sugiyama | KRT18 CYK18 PIG46 | GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR |
| P05787 | S280 | Sugiyama | KRT8 CYK8 | IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL |
| P05787 | S410 | Sugiyama | KRT8 CYK8 | TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL |
| P06733 | S349 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV |
| P06733 | S37 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY |
| P06733 | S40 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK |
| P06733 | T205 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE |
| P07195 | S162 | Sugiyama | LDHB | DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH |
| P07195 | S303 | Sugiyama | LDHB | GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt |
| P07195 | T323 | Sugiyama | LDHB | sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________ |
| P07205 | S393 | Sugiyama | PGK2 PGKB | GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA |
| P07205 | T394 | Sugiyama | PGK2 PGKB | GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL |
| P07237 | T453 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07737 | S58 | Sugiyama | PFN1 | KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL |
| P07737 | S72 | Sugiyama | PFN1 | VGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKs |
| P07737 | S77 | Sugiyama | PFN1 | ssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAP |
| P07737 | T65 | Sugiyama | PFN1 | PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs |
| P07737 | Y60 | Sugiyama | PFN1 | FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ |
| P07814 | S1336 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN |
| P07814 | S739 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV |
| P07864 | S161 | Sugiyama | LDHC LDH3 LDHX | DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH |
| P07900 | S165 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK |
| P07900 | S169 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH |
| P07900 | S315 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | PIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQL |
| P07900 | S623 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII |
| P07900 | S63 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN |
| P07900 | T317 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF |
| P08195 | T401 | Sugiyama | SLC3A2 MDU1 | NSSDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQ |
| P08195 | T415 | Sugiyama | SLC3A2 MDU1 | NKDLLLtssyLsDsGstGEHtKSLVTQYLNATGNRWCSWSL |
| P08238 | S160 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK |
| P08238 | S164 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH |
| P08238 | S307 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | PIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQL |
| P08238 | S452 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy |
| P08238 | S460 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ |
| P08238 | S462 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs |
| P08238 | S58 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| P08238 | T309 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF |
| P08238 | T85 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI |
| P09104 | S37 | Sugiyama | ENO2 | NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY |
| P09104 | S40 | Sugiyama | ENO2 | VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK |
| P09382 | T58 | Sugiyama | LGALS1 | DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF |
| P09496 | S236 | Sugiyama | CLTA | RLCDFNPKSSKQAKDVSRMRsVLIsLKQAPLVH________ |
| P09496 | S240 | Sugiyama | CLTA | FNPKSSKQAKDVSRMRsVLIsLKQAPLVH____________ |
| P09972 | S176 | Sugiyama | ALDOC ALDC | ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG41 | S140 | Sugiyama | CTAGE8 | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| P0DPH7 | S48 | Sugiyama | TUBA3C TUBA2 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P0DPH7 | T51 | Sugiyama | TUBA3C TUBA2 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P10412 | S36 | Sugiyama | H1-4 H1F4 HIST1H1E | EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG |
| P10809 | S488 | Sugiyama | HSPD1 HSP60 | IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG |
| P11142 | T163 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy |
| P11142 | T226 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK |
| P11274 | S371 | Sugiyama | BCR BCR1 D22S11 | SRVsPsPTTyRMFRDKsRsPsQNsQQsFDSssPPtPQCHKR |
| P11586 | S490 | Sugiyama | MTHFD1 MTHFC MTHFD | QTDKALFNRLVPSVNGVRRFsDIQIRRLKRLGIEKTDPTTL |
| P11717 | S1952 | Sugiyama | IGF2R MPRI | DYDRDHEWGFCRHSNSYRTssIIFKCDEDEDIGRPQVFSEV |
| P11940 | T379 | Sugiyama | PABPC1 PAB1 PABP PABP1 PABPC2 | AtKPLyVALAQRKEERQAHLtNQyMQRMASVRAVPNPVINP |
| P12268 | S416 | Sugiyama | IMPDH2 IMPD2 | APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK |
| P12814 | T50 | Sugiyama | ACTN1 | EKQQRKTFTAWCNsHLRKAGtQIENIEEDFRDGLKLMLLLE |
| P12956 | S520 | Sugiyama | XRCC6 G22P1 | PEQAVDLTLPKVEAMNKRLGsLVDEFKELVyPPDyNPEGKV |
| P13073 | S89 | Sugiyama | COX4I1 COX4 | SWssLsMDEKVELYRIKFKEsFAEMNRGSNEWKTVVGGAMF |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13667 | S126 | Sugiyama | PDIA4 ERP70 ERP72 | NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG |
| P13796 | S5 | GPS6|PSP | LCP1 PLS2 | ________________MARGsVsDEEMMELREAFAKVDtDG |
| P13797 | S339 | Sugiyama | PLS3 | PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV |
| P13929 | S37 | Sugiyama | ENO3 | NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY |
| P13929 | S40 | Sugiyama | ENO3 | VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14314 | T469 | Sugiyama | PRKCSH G19P1 | WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt |
| P14618 | S202 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs |
| P14618 | S77 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs |
| P14618 | S97 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP |
| P14618 | T87 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP |
| P14618 | T95 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK |
| P14625 | S514 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK |
| P14625 | S515 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ |
| P14625 | T519 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy |
| P15336 | S62 | Sugiyama | ATF2 CREB2 CREBP1 | LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV |
| P15531 | S120 | Sugiyama | NME1 NDPKA NM23 | KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV |
| P15531 | S122 | Sugiyama | NME1 NDPKA NM23 | GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy |
| P16402 | S37 | Sugiyama | H1-3 H1F3 HIST1H1D | KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG |
| P16403 | S36 | Sugiyama | H1-2 H1F2 HIST1H1C | EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG |
| P17066 | T228 | Sugiyama | HSPA6 HSP70B' | DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR |
| P17544 | S44 | Sugiyama | ATF7 ATFA | LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV |
| P17655 | T464 | Sugiyama | CAPN2 CANPL2 | TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL |
| P17812 | S573 | Sugiyama | CTPS1 CTPS | HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__ |
| P17987 | S544 | Sugiyama | TCP1 CCT1 CCTA | ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________ |
| P18621 | S5 | Sugiyama | RPL17 | ________________MVRysLDPENPtKsCKSRGSNLRVH |
| P18669 | S14 | Sugiyama | PGAM1 PGAMA CDABP0006 | _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG |
| P18754 | S90 | Sugiyama | RCC1 CHC1 | VQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsVEGSEM |
| P19338 | S460 | Sugiyama | NCL | ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST |
| P20674 | T105 | Sugiyama | COX5A | EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY |
| P20810 | S364 | Sugiyama | CAST | ATDKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEK |
| P20810 | S366 | Sugiyama | CAST | DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS |
| P22059 | S379 | Sugiyama | OSBP OSBP1 | FFDAPEIITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLE |
| P22090 | S204 | Sugiyama | RPS4Y1 RPS4Y PRO2646 | IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN |
| P22314 | S46 | Sugiyama | UBA1 A1S9T UBE1 | AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA |
| P22626 | S324 | Sugiyama | HNRNPA2B1 HNRPA2B1 | GNYNQQPSNYGPMKsGNFGGsRNMGGPyGGGNyGPGGsGGs |
| P23246 | S283 | Sugiyama | SFPQ PSF | GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN |
| P23381 | S351 | Sugiyama | WARS1 IFI53 WARS WRS | KPALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTK |
| P23381 | S358 | Sugiyama | WARS1 IFI53 WARS WRS | TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs |
| P23588 | S207 | Sugiyama | EIF4B | DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR |
| P23588 | T205 | Sugiyama | EIF4B | GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR |
| P25054 | S1861 | Sugiyama | APC DP2.5 | DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL |
| P25398 | S107 | Sugiyama | RPS12 | EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy |
| P25789 | T10 | Sugiyama | PSMA4 HC9 PSC9 | ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH |
| P25789 | T9 | Sugiyama | PSMA4 HC9 PSC9 | ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG |
| P26038 | S576 | Sugiyama | MSN | YKtLRQIRQGNTKQRIDEFEsM___________________ |
| P26373 | S181 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE |
| P26373 | T107 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF |
| P26641 | T287 | Sugiyama | EEF1G EF1G PRO1608 | EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL |
| P27708 | S1859 | Sugiyama | CAD | RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP |
| P27824 | S362 | Sugiyama | CANX | WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK |
| P28066 | S172 | Sugiyama | PSMA5 | QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK |
| P28340 | S1064 | Sugiyama | POLD1 POLD | LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK |
| P29083 | T223 | Sugiyama | GTF2E1 TF2E1 | ILEPEPTEIPALKQSKDHAAtTAGAASLAGGHHREAWATKG |
| P29401 | S332 | Sugiyama | TKT | GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK |
| P29401 | S473 | Sugiyama | TKT | AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK |
| P29401 | T346 | Sugiyama | TKT | AKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIECYIAE |
| P29401 | T444 | Sugiyama | TKT | DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT |
| P29692 | S44 | Sugiyama | EEF1D EF1D | RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs |
| P29692 | S60 | Sugiyama | EEF1D EF1D | ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL |
| P29692 | S64 | Sugiyama | EEF1D EF1D | sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI |
| P29692 | T125 | Sugiyama | EEF1D EF1D | IsKLEARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKP |
| P30043 | T190 | Sugiyama | BLVRB FLR SCAN | RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____ |
| P30048 | S199 | Sugiyama | PRDX3 AOP1 | SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF |
| P30085 | S180 | Sugiyama | CMPK1 CMK CMPK UCK UMK UMPK | KPIIDLyEEMGKVKKIDASKsVDEVFDEVVQIFDKEG____ |
| P30086 | S139 | Sugiyama | PEBP1 PBP PEBP | RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE |
| P30086 | S52 | Sugiyama | PEBP1 PBP PEBP | AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD |
| P30086 | T167 | Sugiyama | PEBP1 PBP PEBP | GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK |
| P30086 | T51 | Sugiyama | PEBP1 PBP PEBP | GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP |
| P30533 | S242 | Sugiyama | LRPAP1 A2MRAP | TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD |
| P30740 | S72 | Sugiyama | SERPINB1 ELANH2 MNEI PI2 | AQLSKTFHFNTVEEVHSRFQsLNADINKRGASYILKLANRL |
| P31327 | S898 | Sugiyama | CPS1 | LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS |
| P31948 | S16 | Sugiyama | STIP1 | _____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH |
| P31948 | T143 | Sugiyama | STIP1 | KFMNPFNMPNLYQKLESDPRtRtLLSDPTYRELIEQLRNKP |
| P31948 | T145 | Sugiyama | STIP1 | MNPFNMPNLYQKLESDPRtRtLLSDPTYRELIEQLRNKPSD |
| P32119 | S112 | Sugiyama | PRDX2 NKEFB TDPX1 | KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII |
| P32119 | T142 | Sugiyama | PRDX2 NKEFB TDPX1 | EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF |
| P32969 | S135 | Sugiyama | RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 | RNFLGEKYIRRVRMRPGVACsVsQAQKDELILEGNDIELVS |
| P34931 | T228 | Sugiyama | HSPA1L | DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK |
| P34932 | S76 | Sugiyama | HSPA4 APG2 HSPH2 | VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT |
| P35269 | T154 | Sugiyama | GTF2F1 RAP74 | AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF |
| P35269 | T156 | Sugiyama | GTF2F1 RAP74 | EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI |
| P36578 | S55 | Sugiyama | RPL4 RPL1 | DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR |
| P36578 | S66 | Sugiyama | RPL4 RPL1 | KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR |
| P36578 | T69 | Sugiyama | RPL4 RPL1 | RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P37802 | S185 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______ |
| P37802 | T180 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_ |
| P37837 | S13 | Sugiyama | TALDO1 TAL TALDO TALDOR | ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA |
| P38646 | S89 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA |
| P38646 | T111 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP |
| P38646 | T116 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD |
| P39023 | S13 | Sugiyama | RPL3 OK/SW-cl.32 | ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP |
| P39023 | S265 | Sugiyama | RPL3 OK/SW-cl.32 | HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY |
| P39748 | S255 | Sugiyama | FEN1 RAD2 | CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL |
| P41567 | T46 | Sugiyama | EIF1 SUI1 | GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK |
| P42677 | S78 | Sugiyama | RPS27 MPS1 | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| P43034 | S152 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM |
| P43243 | S188 | Sugiyama | MATR3 KIAA0723 | EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs |
| P43490 | S472 | Sugiyama | NAMPT PBEF PBEF1 | EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_ |
| P45974 | S783 | Sugiyama | USP5 ISOT | IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL |
| P46060 | S454 | Sugiyama | RANGAP1 KIAA1835 SD | VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL |
| P46776 | S68 | Sugiyama | RPL27A | yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV |
| P46779 | S115 | Sugiyama | RPL28 | HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK |
| P46779 | S76 | Sugiyama | RPL28 | DGKGVVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHM |
| P46779 | T75 | Sugiyama | RPL28 | ADGKGVVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRH |
| P46779 | T81 | Sugiyama | RPL28 | VVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMIRKNK |
| P46779 | Y77 | Sugiyama | RPL28 | GKGVVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMI |
| P46783 | S146 | Sugiyama | RPS10 | TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_ |
| P46937 | T378 | Sugiyama | YAP1 YAP65 | DGGtQNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEst |
| P47712 | S724 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL |
| P47712 | S727 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP |
| P47756 | S192 | Sugiyama | CAPZB | TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN |
| P47756 | T186 | Sugiyama | CAPZB | HYKLTSTVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDC |
| P47914 | T155 | Sugiyama | RPL29 | AQAAAPAsVPAQAPKRtQAPtKAsE________________ |
| P48741 | T228 | Sugiyama | HSPA7 HSP70B | DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR |
| P49321 | S704 | Sugiyama | NASP | PGGGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKRKPEE |
| P49321 | S705 | Sugiyama | NASP | GGGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKRKPEEE |
| P49321 | S706 | Sugiyama | NASP | GGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKRKPEEEs |
| P49321 | T700 | Sugiyama | NASP | sGFtPGGGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKR |
| P49419 | S84 | Sugiyama | ALDH7A1 ATQ1 | EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD |
| P49840 | S21 | GPS6|SIGNOR|iPTMNet|EPSD|Sugiyama | GSK3A | MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs |
| P49841 | S21 | iPTMNet|EPSD | GSK3B | MSGRPRttsFAEsCKPVQQPsAFGsMKVSRDKDGSKVTTVV |
| P49841 | S9 | GPS6|SIGNOR|iPTMNet|EPSD|PSP | GSK3B | ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS |
| P50454 | S139 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS |
| P50454 | S141 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI |
| P50454 | Y135 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | LRSLSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYN |
| P51116 | S601 | Sugiyama | FXR2 FMR1L2 | RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ |
| P51116 | T610 | Sugiyama | FXR2 FMR1L2 | RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER |
| P51659 | S318 | PSP | HSD17B4 EDH17B4 SDR8C1 | VLSKIDsEGGVSANHtSRAtstATSGFAGAIGQKLPPFSYA |
| P51858 | S107 | Sugiyama | HDGF HMG1L2 | WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG |
| P51858 | S83 | Sugiyama | HDGF HMG1L2 | LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs |
| P51858 | T94 | Sugiyama | HDGF HMG1L2 | GKPNKRKGFsEGLWEIENNPtVKASGYQSsQKKsCVEEPEP |
| P51991 | S375 | Sugiyama | HNRNPA3 HNRPA3 | ssGsPyGGGyGsGGGsGGyGsRRF_________________ |
| P52272 | S633 | Sugiyama | HNRNPM HNRPM NAGR1 | GGGGAsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKAC |
| P52272 | S637 | Sugiyama | HNRNPM HNRPM NAGR1 | AsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKACQIFV |
| P52298 | S13 | Sugiyama | NCBP2 CBP20 PIG55 | ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE |
| P52742 | S308 | Sugiyama | ZNF135 ZNF61 ZNF78L1 | HQRTHTGEKPYECSECGKSFsFRSSFSQHERTHTGEKPYEC |
| P53365 | S260 | Sugiyama | ARFIP2 POR1 | TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA |
| P53396 | S455 | Sugiyama | ACLY | ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP |
| P53396 | S457 | Sugiyama | ACLY | FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD |
| P53396 | S459 | Sugiyama | ACLY | LNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQDsV |
| P53396 | S656 | Sugiyama | ACLY | IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR |
| P53602 | S231 | Sugiyama | MVD MPD | stVGMRASVETsPLLRFRAEsVVPARMAEMARCIRERDFPS |
| P54652 | T229 | Sugiyama | HSPA2 | DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK |
| P55036 | S358 | Sugiyama | PSMD4 MCB1 | VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_ |
| P55060 | S342 | Sugiyama | CSE1L CAS XPO2 | ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF |
| P57053 | S37 | Sugiyama | H2BC12L H2BFS H2BS1 | KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P57053 | S39 | Sugiyama | H2BC12L H2BFS H2BS1 | VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P58876 | S37 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P58876 | S39 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P60174 | S21 | Sugiyama | TPI1 TPI | MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60174 | T217 | Sugiyama | TPI1 TPI | VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL |
| P60174 | T28 | Sugiyama | TPI1 TPI | FVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVVCAPPtAy |
| P60709 | S199 | Sugiyama | ACTB | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60709 | S60 | Sugiyama | ACTB | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P60709 | Y53 | Sugiyama | ACTB | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P61081 | S175 | Sugiyama | UBE2M UBC12 | NNRRLFEQNVQRSMRGGyIGstyFERCLK____________ |
| P61247 | S236 | Sugiyama | RPS3A FTE1 MFTL | KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy |
| P61313 | S100 | Sugiyama | RPL15 EC45 TCBAP0781 | tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW |
| P61513 | S21 | Sugiyama | RPL37A | MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAKYTCSF |
| P61513 | Y14 | Sugiyama | RPL37A | _______MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQH |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P62081 | T121 | Sugiyama | RPS7 | LPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVG |
| P62081 | T123 | Sugiyama | RPS7 | KPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVGKR |
| P62249 | S9 | Sugiyama | RPS16 | ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN |
| P62258 | S148 | Sugiyama | YWHAE | YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP |
| P62277 | S14 | Sugiyama | RPS13 | _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK |
| P62280 | T15 | Sugiyama | RPS11 | ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR |
| P62701 | S204 | Sugiyama | RPS4X CCG2 RPS4 SCAR | tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62736 | S62 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P62736 | Y55 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P62750 | S43 | Sugiyama | RPL23A | KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK |
| P62807 | S37 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss |
| P62807 | S39 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA |
| P62857 | S23 | Sugiyama | RPS28 | TSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsII |
| P62899 | S15 | Sugiyama | RPL31 | ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG |
| P62906 | S64 | Sugiyama | RPL10A NEDD6 | QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH |
| P62917 | S130 | Sugiyama | RPL8 | GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL |
| P62917 | S14 | Sugiyama | RPL8 | _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF |
| P62917 | T135 | Sugiyama | RPL8 | CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK |
| P62917 | Y133 | Sugiyama | RPL8 | VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG |
| P62937 | T157 | Sugiyama | PPIA CYPA | NIVEAMERFGsRNGKTSKKItIADCGQLE____________ |
| P62942 | T22 | Sugiyama | FKBP1A FKBP1 FKBP12 | GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63104 | T30 | Sugiyama | YWHAZ | AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN |
| P63261 | S199 | Sugiyama | ACTG1 ACTG | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63261 | S60 | Sugiyama | ACTG1 ACTG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P63261 | Y53 | Sugiyama | ACTG1 ACTG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P63267 | S61 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P63267 | Y54 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P67809 | S102 | Sugiyama | YBX1 NSEP1 YB1 | EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA |
| P67809 | S136 | Sugiyama | YBX1 NSEP1 YB1 | GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR |
| P67809 | S209 | Sugiyama | YBX1 NSEP1 YB1 | RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ |
| P67809 | T80 | Sugiyama | YBX1 NSEP1 YB1 | LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKKNNPRKyL |
| P67809 | Y99 | Sugiyama | YBX1 NSEP1 YB1 | DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68032 | S62 | Sugiyama | ACTC1 ACTC | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68032 | Y55 | Sugiyama | ACTC1 ACTC | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S62 | Sugiyama | ACTA1 ACTA | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68133 | Y55 | Sugiyama | ACTA1 ACTA | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68363 | S48 | Sugiyama | TUBA1B | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P68363 | T51 | Sugiyama | TUBA1B | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P68363 | T73 | Sugiyama | TUBA1B | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| P68363 | Y83 | Sugiyama | TUBA1B | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| P68431 | T46 | Sugiyama | H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J | ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL |
| P78371 | S143 | Sugiyama | CCT2 99D8.1 CCTB | PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA |
| P78371 | S60 | Sugiyama | CCT2 99D8.1 CCTB | KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA |
| P78371 | T69 | Sugiyama | CCT2 99D8.1 CCTB | DKILLsSGRDAsLMVtNDGAtILKNIGVDNPAAKVLVDMSR |
| P83731 | S86 | Sugiyama | RPL24 | EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE |
| P83731 | T83 | Sugiyama | RPL24 | QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA |
| P84098 | S12 | Sugiyama | RPL19 | _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI |
| P84098 | S13 | Sugiyama | RPL19 | ________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA |
| P84243 | T46 | Sugiyama | H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B | ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL |
| Q00987 | S166 | PSP | MDM2 | KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs |
| Q02543 | S123 | Sugiyama | RPL18A | AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK |
| Q04637 | T1117 | Sugiyama | EIF4G1 EIF4F EIF4G EIF4GI | ssGGSGAKPSDAAsEAARPAtstLNRFsALQQAVPtEsTDN |
| Q04637 | T1119 | Sugiyama | EIF4G1 EIF4F EIF4G EIF4GI | GGSGAKPSDAAsEAARPAtstLNRFsALQQAVPtEsTDNRR |
| Q04917 | S145 | Sugiyama | YWHAH YWHA1 | KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM |
| Q05682 | S129 | Sugiyama | CALD1 CAD CDM | KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK |
| Q06830 | S126 | Sugiyama | PRDX1 PAGA PAGB TDPX2 | SDPKRtIAQDyGVLKADEGIsFRGLFIIDDKGILRQItVND |
| Q06830 | T143 | Sugiyama | PRDX1 PAGA PAGB TDPX2 | EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF |
| Q07020 | T87 | Sugiyama | RPL18 | IRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRVTS |
| Q07157 | S1153 | Sugiyama | TJP1 ZO1 | EEPAPLsyDsRPRYEQAPRAsALRHEEQPAPGyDtHGRLRP |
| Q07666 | S20 | Sugiyama | KHDRBS1 SAM68 | _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL |
| Q07866 | S445 | Sugiyama | KLC1 KLC KNS2 | PIWMHAEEREECKGKQKDGTsFGEyGGWyKACKVDsPtVTT |
| Q09028 | S147 | Sugiyama | RBBP4 RBAP48 | VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC |
| Q09161 | S22 | Sugiyama | NCBP1 CBP80 NCBP | SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS |
| Q12904 | S140 | Sugiyama | AIMP1 EMAP2 SCYE1 | EKKAKEKIEKKGEKKEKKQQsIAGsADSKPIDVSRLDLRIG |
| Q12904 | S144 | Sugiyama | AIMP1 EMAP2 SCYE1 | KEKIEKKGEKKEKKQQsIAGsADSKPIDVSRLDLRIGCIIT |
| Q12931 | T494 | Sugiyama | TRAP1 HSP75 HSPC5 | ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy |
| Q12965 | T935 | Sugiyama | MYO1E MYO1C | VLQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAA |
| Q12982 | S114 | Sugiyama | BNIP2 NIP2 | EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR |
| Q13045 | S436 | GPS6|SIGNOR|EPSD|PSP | FLII FLIL | AGsGPKDPMARKMRLRRRKDsAQDDQAKQVLKGMSDVAQEK |
| Q13045 | T818 | GPS6|SIGNOR|EPSD|PSP | FLII FLIL | AAALKLGQELCGMLHRPRHAtVSRSLEGTEAQVFKAKFKNW |
| Q13098 | S474 | Sugiyama | GPS1 COPS1 CSN1 | MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___ |
| Q13247 | S297 | Sugiyama | SRSF6 SFRS6 SRP55 | RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP |
| Q13247 | S299 | Sugiyama | SRSF6 SFRS6 SRP55 | RSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPP |
| Q13263 | S473 | Sugiyama | TRIM28 KAP1 RNF96 TIF1B | sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL |
| Q13442 | T18 | Sugiyama | PDAP1 HASPP28 | ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE |
| Q13442 | T97 | Sugiyama | PDAP1 HASPP28 | VEGLIDIENPNRVAQttKKVtQLDLDGPKELSRREREEIEK |
| Q13501 | S28 | Sugiyama | SQSTM1 ORCA OSIL | AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL |
| Q14011 | S159 | Sugiyama | CIRBP A18HNRNP CIRP | RDyySSRsQsGGYSDRssGGsyRDsyDsyATHNE_______ |
| Q14152 | S1028 | Sugiyama | EIF3A EIF3S10 KIAA0139 | NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP |
| Q14152 | S492 | Sugiyama | EIF3A EIF3S10 KIAA0139 | VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ |
| Q14152 | S584 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV |
| Q14152 | S988 | Sugiyama | EIF3A EIF3S10 KIAA0139 | PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN |
| Q14203 | S31 | Sugiyama | DCTN1 | RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL |
| Q14204 | S3082 | Sugiyama | DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 | LHVVFTMNPSSEGLKDRAAtsPALFNRCVLNWFGDWSTEAL |
| Q14247 | S322 | Sugiyama | CTTN EMS1 | ySKGFGGKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEA |
| Q14432 | T311 | Sugiyama | PDE3A | RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR |
| Q14444 | T303 | Sugiyama | CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 | YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV |
| Q14498 | S337 | Sugiyama | RBM39 HCC1 RNPC2 | AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL |
| Q14524 | S484 | SIGNOR | SCN5A | sPLAPVNsHERRSKRRKRMssGtEECGEDRLPKsDsEDGPR |
| Q14524 | S664 | SIGNOR | SCN5A | TSQAPCVDGFEEPGARQRALsAVsVLtsALEELEESRHKCP |
| Q14568 | S165 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK |
| Q14568 | S169 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH |
| Q14671 | S709 | Sugiyama | PUM1 KIAA0099 PUMH1 | LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH |
| Q14676 | T447 | Sugiyama | MDC1 KIAA0170 NFBD1 | WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR |
| Q14847 | Y152 | Sugiyama | LASP1 MLN50 | GPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPtsAPVyQ |
| Q15084 | S156 | Sugiyama | PDIA6 ERP5 P5 TXNDC7 | KDRLGGRSGGYSSGKQGRSDsSSKKDVIELtDDsFDKNVLD |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q15428 | S153 | Sugiyama | SF3A2 SAP62 | LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA |
| Q15459 | S508 | Sugiyama | SF3A1 SAP114 | IGEEEIQKPEEKVTWDGHsGsMARTQQAAQANITLQEQIEA |
| Q15599 | T102 | Sugiyama | NHERF2 SLC9A3R2 | QTRLLVVDQETDEELRRRQLtCTEEMAQRGLPPAHDPWEPK |
| Q15642 | S298 | Sugiyama | TRIP10 CIP4 STOT STP | RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT |
| Q15642 | T302 | Sugiyama | TRIP10 CIP4 STOT STP | VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP |
| Q15818 | S91 | Sugiyama | NPTX1 | TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP |
| Q16513 | S583 | Sugiyama | PKN2 PRK2 PRKCL2 | VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs |
| Q16576 | S146 | Sugiyama | RBBP7 RBAP46 | VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC |
| Q16637 | T25 | Sugiyama | SMN1 SMN SMNT; SMN2 SMNC | sGGsGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDK |
| Q16695 | T46 | Sugiyama | H3-4 H3FT HIST3H3 | ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL |
| Q16763 | T152 | Sugiyama | UBE2S E2EPF OK/SW-cl.73 | EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA |
| Q53EL6 | S76 | Sugiyama | PDCD4 H731 | NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK |
| Q58FF6 | S34 | Sugiyama | HSP90AB4P | IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN |
| Q58FF7 | S58 | Sugiyama | HSP90AB3P HSP90BC | IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q58FF8 | S58 | Sugiyama | HSP90AB2P HSP90BB | IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q5JSH3 | S344 | GPS6 | WDR44 RPH11 | APDGQTVAGEVMGPQRPRsNsGRELtDEEILASVMIKNLDt |
| Q5JTD0 | S361 | Sugiyama | TJAP1 PILT TJP4 | IPRNsPLPNCtyAtRQAISLsLVEEGSERARPSPVPSTPAS |
| Q5QNW6 | S37 | Sugiyama | H2BC18 HIST2H2BF | KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q5QNW6 | S39 | Sugiyama | H2BC18 HIST2H2BF | VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q5SSJ5 | S227 | Sugiyama | HP1BP3 | LKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRKNR |
| Q5SW79 | S881 | Sugiyama | CEP170 FAM68A KAB KIAA0470 | sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM |
| Q5T0N5 | S488 | Sugiyama | FNBP1L C1orf39 TOCA1 | NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD |
| Q5T1M5 | S1162 | Sugiyama | FKBP15 KIAA0674 | EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP |
| Q5VT52 | S1070 | Sugiyama | RPRD2 KIAA0460 HSPC099 | TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy |
| Q5VT52 | S1180 | Sugiyama | RPRD2 KIAA0460 HSPC099 | TGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPsPLE |
| Q6A1A2 | S149 | Sugiyama | PDPK2P PDPK2 | YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL |
| Q6NXT2 | T45 | Sugiyama | H3-5 H3F3C | AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL |
| Q6PEY2 | S48 | Sugiyama | TUBA3E | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q6PEY2 | T51 | Sugiyama | TUBA3E | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q6PKG0 | S850 | Sugiyama | LARP1 KIAA0731 LARP | sHVGWVMDSREHRPRtAsIsssPsEGtPtVGsyGCtPQsLP |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6ZMR3 | S161 | Sugiyama | LDHAL6A LDHL2 | DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH |
| Q71DI3 | T46 | Sugiyama | H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D | ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL |
| Q71U36 | S48 | Sugiyama | TUBA1A TUBA3 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q71U36 | T51 | Sugiyama | TUBA1A TUBA3 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q71U36 | T73 | Sugiyama | TUBA1A TUBA3 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q71U36 | Y83 | Sugiyama | TUBA1A TUBA3 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q71UM5 | S78 | Sugiyama | RPS27L | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| Q7Z417 | S652 | Sugiyama | NUFIP2 KIAA1321 PIG1 | NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI |
| Q7Z5L9 | S455 | Sugiyama | IRF2BP2 | AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG |
| Q7Z5L9 | S457 | Sugiyama | IRF2BP2 | GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ |
| Q7Z7G1 | S331 | Sugiyama | CLNK MIST | IGEYSRQAVEEAFMKENKDGsFLVRDCSTKSKEEPYVLAVF |
| Q86UF2 | S140 | Sugiyama | CTAGE6 CTAGE6P | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| Q86V81 | S142 | Sugiyama | ALYREF ALY BEF THOC4 | IQELFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKA |
| Q86VQ1 | S223 | Sugiyama | GLCCI1 | QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR |
| Q86Y82 | S139 | GPS6 | STX12 | AVQRRVSEKEKESIARARAGsRLsAEERQREEQLVSFDSHE |
| Q86YS3 | S527 | GPS6 | RAB11FIP4 ARFO2 KIAA1821 | LEHLQMYKLDCERPGRGRSAsSGLGEFNARAREVELEHEVK |
| Q8IWX8 | S904 | Sugiyama | CHERP DAN26 SCAF6 | KGVGVALDDPyENyRRNKsysFIARMKARDECK________ |
| Q8IX94 | S140 | Sugiyama | CTAGE4 | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| Q8N3F8 | S309 | Sugiyama | MICALL1 KIAA1668 MIRAB13 | KLQELAsPPAGRPtPAPRKAsEsTtPAPPtPRPRssLQQEN |
| Q8N8S7 | S125 | Sugiyama | ENAH MENA | MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR |
| Q8NBJ7 | S256 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG |
| Q8NBJ7 | T272 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | LRGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAA |
| Q8NBJ7 | T273 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | RGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAAD |
| Q8NBS9 | S285 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | LLWFRDGKKVDQYKGKRDLEsLREyVEsQLQRTETGATETV |
| Q8NBS9 | S292 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV |
| Q8ND56 | T384 | Sugiyama | LSM14A C19orf13 FAM61A RAP55 RAP55A | DKTKsFFDNIsCDDNRERRPtWAEERRLNAETFGIPLRPNR |
| Q8TAM6 | S280 | Sugiyama | ERMN KIAA1189 | TISYRKIRKGNTKQRIDEFEsMMHL________________ |
| Q8TD19 | S13 | Sugiyama | NEK9 KIAA1995 NEK8 NERCC | ________MsVLGEYERHCDsINSDFGSEsGGCGDssPGPS |
| Q8TEW0 | S962 | Sugiyama | PARD3 PAR3 PAR3A | DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ |
| Q8TEW0 | T965 | Sugiyama | PARD3 PAR3 PAR3A | MEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQEKG |
| Q8WWL2 | S476 | Sugiyama | SPIRE2 KIAA1832 SPIR2 | GLQSATHPPGGTEPPRPRAGsAHVWRPGSRDQGTCPASVSD |
| Q8WX93 | S479 | Sugiyama | PALLD KIAA0992 CGI-151 | VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE |
| Q92597 | T366 | Sugiyama | NDRG1 CAP43 DRG1 RTP | tSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAG |
| Q92835 | S27 | Sugiyama | INPP5D SHIP SHIP1 | HGNITRSKAEELLSRTGKDGsFLVRAsESISRAYALCVLYR |
| Q92945 | S193 | Sugiyama | KHSRP FUBP2 | DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS |
| Q93052 | S313 | Sugiyama | LPP | QGRyyEGyyAAGPGyGGRNDsDPtyGQQGHPNtWKREPGyt |
| Q93079 | S37 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q93079 | S39 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q96BR1 | T320 | Sugiyama | SGK3 CISK SGKL | VVLTDFGLCKEGIAISDTTTtFCGTPEYLAPEVIRKQPYDN |
| Q96G46 | T240 | Sugiyama | DUS3L | KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC |
| Q96J02 | S450 | GPS6|EPSD|PSP | ITCH | QSKEFDPLGPLPPGWEKRTDsNGRVYFVNHNTRITQWEDPR |
| Q96J02 | T385 | GPS6|EPSD|PSP | ITCH | ERRVDNMGRIyYVDHFTRTTtWQRPTLESVRNYEQWQLQRS |
| Q96JP5 | S85 | Sugiyama | ZFP91 ZNF757 FKSG11 | AAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPsPV |
| Q99584 | S32 | Sugiyama | S100A13 | SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD |
| Q99613 | S754 | Sugiyama | EIF3C EIF3S8 | REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK |
| Q99613 | S865 | Sugiyama | EIF3C EIF3S8 | HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF |
| Q99877 | S37 | Sugiyama | H2BC15 H2BFD HIST1H2BN | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99877 | S39 | Sugiyama | H2BC15 H2BFD HIST1H2BN | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99879 | S37 | Sugiyama | H2BC14 H2BFE HIST1H2BM | KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99879 | S39 | Sugiyama | H2BC14 H2BFE HIST1H2BM | INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99880 | S37 | Sugiyama | H2BC13 H2BFC HIST1H2BL | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99880 | S39 | Sugiyama | H2BC13 H2BFC HIST1H2BL | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q9BQE3 | S48 | Sugiyama | TUBA1C TUBA6 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q9BQE3 | T51 | Sugiyama | TUBA1C TUBA6 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q9BQE3 | T73 | Sugiyama | TUBA1C TUBA6 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q9BQE3 | Y83 | Sugiyama | TUBA1C TUBA6 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q9BTC0 | S1456 | Sugiyama | DIDO1 C20orf158 DATF1 KIAA0333 | EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ |
| Q9BW61 | S33 | Sugiyama | DDA1 C19orf58 PCIA1 | KSNFSRFHADSVCKASNRRPsVYLPTREYPSEQIIVTEKTN |
| Q9BWD1 | S226 | Sugiyama | ACAT2 ACTL | LVstRKGLIEVKtDEFPRHGsNIEAMSKLKPYFLTDGTGTV |
| Q9BWD1 | T218 | Sugiyama | ACAT2 ACTL | FDKEIVPVLVstRKGLIEVKtDEFPRHGsNIEAMSKLKPYF |
| Q9BY44 | S526 | Sugiyama | EIF2A CDA02 MSTP004 MSTP089 | sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9C0C2 | S1620 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT |
| Q9GZT3 | S15 | Sugiyama | SLIRP C14orf156 DC23 DC50 PD04872 | ______MAASAARGAAALRRsINQPVAFVRRIPWTAASSQL |
| Q9H0H5 | T249 | Sugiyama | RACGAP1 KIAA1478 MGCRACGAP | PIEAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPR |
| Q9H0H5 | T251 | Sugiyama | RACGAP1 KIAA1478 MGCRACGAP | EAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTE |
| Q9H4A3 | T2245 | Sugiyama | WNK1 HSN2 KDP KIAA0344 PRKWNK1 | TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS |
| Q9H4A3 | T2247 | Sugiyama | WNK1 HSN2 KDP KIAA0344 PRKWNK1 | NSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLSGR |
| Q9HA77 | S548 | Sugiyama | CARS2 OK/SW-cl.10 | TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____ |
| Q9NP61 | S367 | Sugiyama | ARFGAP3 ARFGAP1 | DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT |
| Q9NQ39 | S157 | Sugiyama | RPS10P5 RPS10L | TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_ |
| Q9NRA8 | S353 | Sugiyama | EIF4ENIF1 | SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL |
| Q9NRL3 | T338 | Sugiyama | STRN4 ZIN | EFDFLGSGEDGEGAPDPRRCtVDGsPHELESRRVKLQGILA |
| Q9NYF8 | S320 | Sugiyama | BCLAF1 BTF KIAA0164 | sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF |
| Q9NZ09 | S207 | Sugiyama | UBAP1 NAG20 | TTGPIMAQLLDNNLPRGGsGsVLQDEEVLAsLERATLDFKP |
| Q9P2T1 | S37 | Sugiyama | GMPR2 | LRPKRSTLKsRsEVDLTRSFsFRNSKQTYSGVPIIAANMDT |
| Q9UBP6 | S27 | Sugiyama | METTL1 C12orf1 | NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS |
| Q9UGV2 | S327 | Sugiyama | NDRG3 | KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV |
| Q9UGV2 | S331 | Sugiyama | NDRG3 | QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ |
| Q9UGV2 | S334 | Sugiyama | NDRG3 | GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG |
| Q9UGV2 | S335 | Sugiyama | NDRG3 | YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt |
| Q9UGV2 | T329 | Sugiyama | NDRG3 | FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts |
| Q9UGV2 | T332 | Sugiyama | NDRG3 | GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs |
| Q9UI15 | S185 | Sugiyama | TAGLN3 NP25 | EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______ |
| Q9UII2 | S39 | Sugiyama | ATP5IF1 ATPI ATPIF1 | TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF |
| Q9UII2 | S63 | Sugiyama | ATP5IF1 ATPI ATPIF1 | AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK |
| Q9UKV3 | S561 | Sugiyama | ACIN1 ACINUS KIAA0670 | GITEECLKQPsLEQKEGRRAsHtLLPSHRLKQSADSSSSRS |
| Q9UNH7 | S316 | Sugiyama | SNX6 | LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD |
| Q9UNZ2 | S176 | Sugiyama | NSFL1C UBXN2C | RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG |
| Q9UNZ2 | S74 | Sugiyama | NSFL1C UBXN2C | SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF |
| Q9UPQ0 | S201 | Sugiyama | LIMCH1 KIAA1102 | DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV |
| Q9UPQ0 | S377 | Sugiyama | LIMCH1 KIAA1102 | LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA |
| Q9UQ35 | S1101 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF |
| Q9UQ35 | S1541 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs |
| Q9UQ35 | S854 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE |
| Q9UQ35 | S857 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFEssP |
| Q9UQ35 | S990 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sGsssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLs |
| Q9UQ35 | S992 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs |
| Q9UQ35 | T848 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | KtPsRQsHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQ |
| Q9Y2B0 | S63 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE |
| Q9Y2T7 | S137 | Sugiyama | YBX2 CSDA3 MSY2 | EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA |
| Q9Y2T7 | T115 | Sugiyama | YBX2 CSDA3 MSY2 | LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL |
| Q9Y3S1 | T2157 | Sugiyama | WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 | GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA |
| Q9Y3S1 | T2159 | Sugiyama | WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 | QPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAAQL |
| Q9Y5M8 | S213 | Sugiyama | SRPRB PSEC0230 | IQQQLEKELNTLRVTRsAAPstLDssstAPAQLGKKGKEFE |
| Q9Y6D5 | S277 | Sugiyama | ARFGEF2 ARFGEP2 BIG2 | RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Signal Transduction | R-HSA-162582 | 2.529110e-11 | 10.597 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 3.451860e-09 | 8.462 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 3.218073e-09 | 8.492 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 2.930278e-09 | 8.533 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 8.788630e-09 | 8.056 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 1.587842e-08 | 7.799 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.253072e-07 | 6.902 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 1.620042e-07 | 6.790 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.780390e-07 | 6.749 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 3.241978e-07 | 6.489 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 8.274280e-07 | 6.082 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 8.374410e-07 | 6.077 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 1.512136e-06 | 5.820 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 1.785326e-06 | 5.748 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.808887e-06 | 5.743 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 5.053689e-06 | 5.296 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 5.265265e-06 | 5.279 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 5.659434e-06 | 5.247 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 6.737333e-06 | 5.172 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 6.953766e-06 | 5.158 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 9.288501e-06 | 5.032 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 9.036320e-06 | 5.044 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 1.660787e-05 | 4.780 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 1.756999e-05 | 4.755 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 2.122733e-05 | 4.673 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 2.401030e-05 | 4.620 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 2.474816e-05 | 4.606 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 3.905522e-05 | 4.408 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 4.013492e-05 | 4.396 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 4.209172e-05 | 4.376 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 4.666041e-05 | 4.331 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 4.582670e-05 | 4.339 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 5.400329e-05 | 4.268 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 6.521837e-05 | 4.186 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 8.605913e-05 | 4.065 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 8.296477e-05 | 4.081 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 9.183114e-05 | 4.037 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 1.067946e-04 | 3.971 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.113542e-04 | 3.953 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.204742e-04 | 3.919 | 0 | 0 |
| M Phase | R-HSA-68886 | 1.258784e-04 | 3.900 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.365671e-04 | 3.865 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.573887e-04 | 3.803 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 1.904743e-04 | 3.720 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 2.058567e-04 | 3.686 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.242945e-04 | 3.649 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 2.498341e-04 | 3.602 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 2.550417e-04 | 3.593 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 2.759574e-04 | 3.559 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 3.147467e-04 | 3.502 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 3.261389e-04 | 3.487 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 3.304214e-04 | 3.481 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 3.574106e-04 | 3.447 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 3.439649e-04 | 3.463 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 3.491464e-04 | 3.457 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 3.713702e-04 | 3.430 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 3.687757e-04 | 3.433 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 3.860884e-04 | 3.413 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 3.910485e-04 | 3.408 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 3.860884e-04 | 3.413 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 4.939957e-04 | 3.306 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 5.038289e-04 | 3.298 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 5.290293e-04 | 3.277 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 5.326514e-04 | 3.274 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 5.596886e-04 | 3.252 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 5.615033e-04 | 3.251 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 5.974093e-04 | 3.224 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 5.974093e-04 | 3.224 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 5.875352e-04 | 3.231 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 5.838511e-04 | 3.234 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 5.767490e-04 | 3.239 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 6.308461e-04 | 3.200 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 6.522539e-04 | 3.186 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 6.522539e-04 | 3.186 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 6.308461e-04 | 3.200 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 6.534712e-04 | 3.185 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 6.546806e-04 | 3.184 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 7.404257e-04 | 3.131 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 8.613592e-04 | 3.065 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 8.848942e-04 | 3.053 | 0 | 0 |
| Kinesins | R-HSA-983189 | 8.848942e-04 | 3.053 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 9.076512e-04 | 3.042 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 9.588028e-04 | 3.018 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 9.163583e-04 | 3.038 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 9.810823e-04 | 3.008 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 1.012499e-03 | 2.995 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.024291e-03 | 2.990 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 1.024291e-03 | 2.990 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 1.126641e-03 | 2.948 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 1.203374e-03 | 2.920 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 1.225017e-03 | 2.912 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 1.232051e-03 | 2.909 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 1.277490e-03 | 2.894 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 1.416230e-03 | 2.849 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 1.416230e-03 | 2.849 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 1.364066e-03 | 2.865 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 1.508961e-03 | 2.821 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.566374e-03 | 2.805 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.668725e-03 | 2.778 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.739917e-03 | 2.759 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 1.720557e-03 | 2.764 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 1.775677e-03 | 2.751 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 1.846633e-03 | 2.734 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.978303e-03 | 2.704 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 1.984982e-03 | 2.702 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 2.107742e-03 | 2.676 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 2.348265e-03 | 2.629 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 2.390134e-03 | 2.622 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 2.309769e-03 | 2.636 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 2.563234e-03 | 2.591 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 2.572065e-03 | 2.590 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 2.731005e-03 | 2.564 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 3.110659e-03 | 2.507 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 3.110659e-03 | 2.507 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 3.118681e-03 | 2.506 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 3.118681e-03 | 2.506 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 3.285400e-03 | 2.483 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 3.118681e-03 | 2.506 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 3.322959e-03 | 2.478 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 3.380173e-03 | 2.471 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 3.380173e-03 | 2.471 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 3.802914e-03 | 2.420 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 3.824947e-03 | 2.417 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 4.022536e-03 | 2.396 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 4.169000e-03 | 2.380 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 4.169000e-03 | 2.380 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 4.169000e-03 | 2.380 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 4.169000e-03 | 2.380 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 3.966366e-03 | 2.402 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 3.982681e-03 | 2.400 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 4.282004e-03 | 2.368 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 4.339030e-03 | 2.363 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 4.493621e-03 | 2.347 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 4.493621e-03 | 2.347 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 4.587186e-03 | 2.338 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 4.587186e-03 | 2.338 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 5.204220e-03 | 2.284 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 5.024036e-03 | 2.299 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 5.024036e-03 | 2.299 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 4.992268e-03 | 2.302 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 5.288209e-03 | 2.277 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 5.498667e-03 | 2.260 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 5.869723e-03 | 2.231 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 6.074917e-03 | 2.216 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 6.268068e-03 | 2.203 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 6.915305e-03 | 2.160 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 6.638346e-03 | 2.178 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 6.638346e-03 | 2.178 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 6.655910e-03 | 2.177 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 6.438482e-03 | 2.191 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 6.925410e-03 | 2.160 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 6.898597e-03 | 2.161 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 6.664744e-03 | 2.176 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 6.981893e-03 | 2.156 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 6.981893e-03 | 2.156 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 7.015900e-03 | 2.154 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 7.262848e-03 | 2.139 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 7.760664e-03 | 2.110 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 7.760664e-03 | 2.110 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 7.760664e-03 | 2.110 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 7.761640e-03 | 2.110 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 7.822604e-03 | 2.107 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 7.866599e-03 | 2.104 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 8.020904e-03 | 2.096 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 8.816482e-03 | 2.055 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 8.413873e-03 | 2.075 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 8.648368e-03 | 2.063 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 8.882392e-03 | 2.051 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 8.816482e-03 | 2.055 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 9.114217e-03 | 2.040 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 9.450668e-03 | 2.025 | 0 | 0 |
| Depurination | R-HSA-73927 | 9.608713e-03 | 2.017 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 9.799910e-03 | 2.009 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 1.000251e-02 | 2.000 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 1.064078e-02 | 1.973 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.099556e-02 | 1.959 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 1.239473e-02 | 1.907 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 1.143354e-02 | 1.942 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 1.191925e-02 | 1.924 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 1.175371e-02 | 1.930 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 1.130126e-02 | 1.947 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 1.249233e-02 | 1.903 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of cell cycle factors | R-HSA-8866911 | 1.348635e-02 | 1.870 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 1.485372e-02 | 1.828 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.496894e-02 | 1.825 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 1.691755e-02 | 1.772 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 1.514230e-02 | 1.820 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 1.588354e-02 | 1.799 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 1.550998e-02 | 1.809 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 1.700617e-02 | 1.769 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.514230e-02 | 1.820 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.514230e-02 | 1.820 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 1.514230e-02 | 1.820 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.640085e-02 | 1.785 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 1.668494e-02 | 1.778 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 1.691028e-02 | 1.772 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 1.710562e-02 | 1.767 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 1.710562e-02 | 1.767 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.817009e-02 | 1.741 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 1.853348e-02 | 1.732 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 1.861396e-02 | 1.730 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.861396e-02 | 1.730 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 1.861396e-02 | 1.730 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 1.883193e-02 | 1.725 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 1.926756e-02 | 1.715 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 2.060584e-02 | 1.686 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 2.085446e-02 | 1.681 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 2.155133e-02 | 1.667 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 2.200275e-02 | 1.658 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 2.225457e-02 | 1.653 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 2.225457e-02 | 1.653 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 2.225457e-02 | 1.653 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 2.252827e-02 | 1.647 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 2.287236e-02 | 1.641 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 2.290255e-02 | 1.640 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 2.320318e-02 | 1.634 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 2.655374e-02 | 1.576 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 2.489986e-02 | 1.604 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 2.659872e-02 | 1.575 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 2.516854e-02 | 1.599 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 2.606230e-02 | 1.584 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 2.659872e-02 | 1.575 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 2.655374e-02 | 1.576 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 2.489986e-02 | 1.604 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 2.672902e-02 | 1.573 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 2.731231e-02 | 1.564 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 2.731231e-02 | 1.564 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 2.741131e-02 | 1.562 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 2.742082e-02 | 1.562 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.774892e-02 | 1.557 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 2.844261e-02 | 1.546 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.916204e-02 | 1.535 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.937919e-02 | 1.532 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 3.008824e-02 | 1.522 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 3.008824e-02 | 1.522 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 3.047465e-02 | 1.516 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 3.059082e-02 | 1.514 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 3.195744e-02 | 1.495 | 0 | 0 |
| Formation of editosomes by ADAR proteins | R-HSA-77042 | 3.699706e-02 | 1.432 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 3.699706e-02 | 1.432 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 3.699706e-02 | 1.432 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 3.699706e-02 | 1.432 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 3.699706e-02 | 1.432 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 3.699706e-02 | 1.432 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 3.384012e-02 | 1.471 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 3.648484e-02 | 1.438 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 3.648484e-02 | 1.438 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 3.648484e-02 | 1.438 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 3.769124e-02 | 1.424 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 3.565096e-02 | 1.448 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 3.677397e-02 | 1.434 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 3.732434e-02 | 1.428 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 3.458260e-02 | 1.461 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 3.514366e-02 | 1.454 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 3.376115e-02 | 1.472 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 3.366426e-02 | 1.473 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 3.677397e-02 | 1.434 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 3.677397e-02 | 1.434 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 3.574733e-02 | 1.447 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 3.614056e-02 | 1.442 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 3.384012e-02 | 1.471 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 3.677397e-02 | 1.434 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 3.849642e-02 | 1.415 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 3.958063e-02 | 1.403 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 3.971468e-02 | 1.401 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 4.058423e-02 | 1.392 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 4.074333e-02 | 1.390 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 4.111117e-02 | 1.386 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 4.234768e-02 | 1.373 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 4.269971e-02 | 1.370 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 4.272315e-02 | 1.369 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 4.289651e-02 | 1.368 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 4.549056e-02 | 1.342 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 4.554306e-02 | 1.342 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 4.554306e-02 | 1.342 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 4.645594e-02 | 1.333 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 4.829807e-02 | 1.316 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 4.836021e-02 | 1.316 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 4.844919e-02 | 1.315 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 4.866802e-02 | 1.313 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 4.920222e-02 | 1.308 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 5.216016e-02 | 1.283 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 5.216016e-02 | 1.283 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 5.302162e-02 | 1.276 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 5.427802e-02 | 1.265 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 6.297971e-02 | 1.201 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 5.685753e-02 | 1.245 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 5.685753e-02 | 1.245 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 6.163748e-02 | 1.210 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 6.408059e-02 | 1.193 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 6.501171e-02 | 1.187 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 6.036531e-02 | 1.219 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 6.036531e-02 | 1.219 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 5.471157e-02 | 1.262 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 6.459276e-02 | 1.190 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 6.163748e-02 | 1.210 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 5.571839e-02 | 1.254 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 5.813454e-02 | 1.236 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 6.297971e-02 | 1.201 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 6.297971e-02 | 1.201 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 6.297971e-02 | 1.201 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 5.512711e-02 | 1.259 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 5.685753e-02 | 1.245 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 5.538440e-02 | 1.257 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.297505e-02 | 1.201 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 5.684890e-02 | 1.245 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 6.556523e-02 | 1.183 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 5.850474e-02 | 1.233 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 6.141783e-02 | 1.212 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 6.408059e-02 | 1.193 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 5.605939e-02 | 1.251 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 6.297505e-02 | 1.201 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 5.512711e-02 | 1.259 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 6.578285e-02 | 1.182 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 6.578285e-02 | 1.182 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 6.578285e-02 | 1.182 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 6.589682e-02 | 1.181 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 6.593810e-02 | 1.181 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 6.602782e-02 | 1.180 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 6.883220e-02 | 1.162 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 6.883220e-02 | 1.162 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 6.892066e-02 | 1.162 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 6.971448e-02 | 1.157 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 6.971448e-02 | 1.157 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 7.088958e-02 | 1.149 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 7.185284e-02 | 1.144 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 7.413565e-02 | 1.130 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 7.497848e-02 | 1.125 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 7.519029e-02 | 1.124 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 7.519029e-02 | 1.124 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 7.556083e-02 | 1.122 | 0 | 0 |
| TGFBR3 regulates FGF2 signaling | R-HSA-9839397 | 7.556083e-02 | 1.122 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 7.556083e-02 | 1.122 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 7.706706e-02 | 1.113 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 7.774248e-02 | 1.109 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 7.818987e-02 | 1.107 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 7.818987e-02 | 1.107 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 7.818987e-02 | 1.107 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 7.875750e-02 | 1.104 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 7.938663e-02 | 1.100 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 8.178702e-02 | 1.087 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 8.192184e-02 | 1.087 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 8.410366e-02 | 1.075 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 8.411221e-02 | 1.075 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 8.411221e-02 | 1.075 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 8.411221e-02 | 1.075 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 8.508402e-02 | 1.070 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 8.515033e-02 | 1.070 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 8.603874e-02 | 1.065 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 8.603874e-02 | 1.065 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 8.648382e-02 | 1.063 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 8.648382e-02 | 1.063 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 8.648382e-02 | 1.063 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 8.989853e-02 | 1.046 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 8.989853e-02 | 1.046 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 8.989853e-02 | 1.046 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.139367e-02 | 1.039 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 9.608684e-02 | 1.017 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 9.608684e-02 | 1.017 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 9.608684e-02 | 1.017 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 9.608684e-02 | 1.017 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 9.608684e-02 | 1.017 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 9.608684e-02 | 1.017 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 9.608684e-02 | 1.017 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 1.158668e-01 | 0.936 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.158668e-01 | 0.936 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 9.968983e-02 | 1.001 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 9.968983e-02 | 1.001 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 9.757636e-02 | 1.011 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 1.138330e-01 | 0.944 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 1.115227e-01 | 0.953 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.083643e-01 | 0.965 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 1.089420e-01 | 0.963 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 1.158668e-01 | 0.936 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 1.013029e-01 | 0.994 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 1.089420e-01 | 0.963 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 9.373510e-02 | 1.028 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 1.046955e-01 | 0.980 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 9.423954e-02 | 1.026 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 9.823051e-02 | 1.008 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 9.968983e-02 | 1.001 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 9.347022e-02 | 1.029 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 1.123295e-01 | 0.950 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 1.083643e-01 | 0.965 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 1.174028e-01 | 0.930 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 1.174028e-01 | 0.930 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 1.186536e-01 | 0.926 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.189014e-01 | 0.925 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 1.207447e-01 | 0.918 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 1.207447e-01 | 0.918 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 1.207447e-01 | 0.918 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 1.207447e-01 | 0.918 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 1.207447e-01 | 0.918 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.207447e-01 | 0.918 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 1.210739e-01 | 0.917 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 1.220937e-01 | 0.913 | 0 | 0 |
| mRNA Editing: A to I Conversion | R-HSA-75064 | 1.220937e-01 | 0.913 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 1.220937e-01 | 0.913 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 1.220937e-01 | 0.913 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 1.220937e-01 | 0.913 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 1.220937e-01 | 0.913 | 0 | 0 |
| C6 deamination of adenosine | R-HSA-75102 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 1.220937e-01 | 0.913 | 0 | 0 |
| Potassium transport channels | R-HSA-1296067 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 1.220937e-01 | 0.913 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 1.220937e-01 | 0.913 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 1.220937e-01 | 0.913 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 1.220937e-01 | 0.913 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.236875e-01 | 0.908 | 0 | 0 |
| Drug resistance of KIT mutants | R-HSA-9669937 | 1.394323e-01 | 0.856 | 0 | 0 |
| KIT mutants bind TKIs | R-HSA-9669921 | 1.394323e-01 | 0.856 | 0 | 0 |
| Sunitinib-resistant KIT mutants | R-HSA-9669934 | 1.394323e-01 | 0.856 | 0 | 0 |
| Dasatinib-resistant KIT mutants | R-HSA-9669914 | 1.394323e-01 | 0.856 | 0 | 0 |
| Regorafenib-resistant KIT mutants | R-HSA-9669929 | 1.394323e-01 | 0.856 | 0 | 0 |
| Nilotinib-resistant KIT mutants | R-HSA-9669926 | 1.394323e-01 | 0.856 | 0 | 0 |
| Masitinib-resistant KIT mutants | R-HSA-9669924 | 1.394323e-01 | 0.856 | 0 | 0 |
| Sorafenib-resistant KIT mutants | R-HSA-9669936 | 1.394323e-01 | 0.856 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 1.394323e-01 | 0.856 | 0 | 0 |
| Imatinib-resistant KIT mutants | R-HSA-9669917 | 1.394323e-01 | 0.856 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 1.548466e-01 | 0.810 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 1.617025e-01 | 0.791 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 1.617025e-01 | 0.791 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 1.617025e-01 | 0.791 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 1.617025e-01 | 0.791 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 1.617025e-01 | 0.791 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.374085e-01 | 0.862 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 1.605641e-01 | 0.794 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 1.605641e-01 | 0.794 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 1.605641e-01 | 0.794 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.361776e-01 | 0.866 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 1.328644e-01 | 0.877 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 1.562615e-01 | 0.806 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 1.285221e-01 | 0.891 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 1.506026e-01 | 0.822 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 1.506026e-01 | 0.822 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 1.316901e-01 | 0.880 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.531606e-01 | 0.815 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 1.245114e-01 | 0.905 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 1.627916e-01 | 0.788 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 1.559622e-01 | 0.807 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 1.335367e-01 | 0.874 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 1.596830e-01 | 0.797 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 1.562615e-01 | 0.806 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.361776e-01 | 0.866 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 1.531606e-01 | 0.815 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 1.513477e-01 | 0.820 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 1.342565e-01 | 0.872 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 1.380177e-01 | 0.860 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 1.424365e-01 | 0.846 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 1.509258e-01 | 0.821 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 1.652115e-01 | 0.782 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 1.342565e-01 | 0.872 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 1.342565e-01 | 0.872 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 1.342565e-01 | 0.872 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 1.562615e-01 | 0.806 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 1.560406e-01 | 0.807 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 1.380177e-01 | 0.860 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 1.611704e-01 | 0.793 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.380177e-01 | 0.860 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 1.328644e-01 | 0.877 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 1.606783e-01 | 0.794 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.327151e-01 | 0.877 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 1.605641e-01 | 0.794 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 1.361776e-01 | 0.866 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 1.562615e-01 | 0.806 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 1.300507e-01 | 0.886 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 1.380177e-01 | 0.860 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 1.456553e-01 | 0.837 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 1.380413e-01 | 0.860 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 1.599326e-01 | 0.796 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 1.288355e-01 | 0.890 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 1.562615e-01 | 0.806 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 1.361776e-01 | 0.866 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.562615e-01 | 0.806 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 1.605641e-01 | 0.794 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 1.410683e-01 | 0.851 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 1.685445e-01 | 0.773 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 1.690803e-01 | 0.772 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 1.693796e-01 | 0.771 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 1.705073e-01 | 0.768 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 1.706498e-01 | 0.768 | 0 | 0 |
| Activation of BIM and translocation to mitochondria | R-HSA-111446 | 1.736254e-01 | 0.760 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 1.750837e-01 | 0.757 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 1.775520e-01 | 0.751 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 1.775520e-01 | 0.751 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 1.775520e-01 | 0.751 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 1.775520e-01 | 0.751 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 1.775520e-01 | 0.751 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 1.775520e-01 | 0.751 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 1.788113e-01 | 0.748 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 1.788113e-01 | 0.748 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 1.796750e-01 | 0.746 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 2.594302e-01 | 0.586 | 0 | 0 |
| Defective SLC26A4 causes Pendred syndrome (PDS) | R-HSA-5619046 | 2.594302e-01 | 0.586 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.594302e-01 | 0.586 | 0 | 0 |
| Impaired BRCA2 translocation to the nucleus | R-HSA-9709275 | 2.594302e-01 | 0.586 | 0 | 0 |
| Impaired BRCA2 binding to SEM1 (DSS1) | R-HSA-9763198 | 2.594302e-01 | 0.586 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.594302e-01 | 0.586 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 2.278586e-01 | 0.642 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 2.278586e-01 | 0.642 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 2.278586e-01 | 0.642 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 2.278586e-01 | 0.642 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 2.278586e-01 | 0.642 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 2.278586e-01 | 0.642 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 2.278586e-01 | 0.642 | 0 | 0 |
| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | R-HSA-2644607 | 2.278586e-01 | 0.642 | 0 | 0 |
| FBXW7 Mutants and NOTCH1 in Cancer | R-HSA-2644605 | 2.278586e-01 | 0.642 | 0 | 0 |
| PI and PC transport between ER and Golgi membranes | R-HSA-1483196 | 3.627014e-01 | 0.440 | 0 | 0 |
| Signaling by juxtamembrane domain KIT mutants | R-HSA-9669935 | 3.627014e-01 | 0.440 | 0 | 0 |
| Interactions of Tat with host cellular proteins | R-HSA-176034 | 3.627014e-01 | 0.440 | 0 | 0 |
| Signaling by extracellular domain mutants of KIT | R-HSA-9680187 | 3.627014e-01 | 0.440 | 0 | 0 |
| Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) | R-HSA-5660686 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5619081 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective MMADHC causes MMAHCD | R-HSA-3359473 | 3.627014e-01 | 0.440 | 0 | 0 |
| PTEN Loss of Function in Cancer | R-HSA-5674404 | 3.627014e-01 | 0.440 | 0 | 0 |
| TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | R-HSA-6791055 | 3.627014e-01 | 0.440 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 3.627014e-01 | 0.440 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5660724 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome | R-HSA-5678420 | 3.627014e-01 | 0.440 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 3.627014e-01 | 0.440 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 3.627014e-01 | 0.440 | 0 | 0 |
| Intestinal infectious diseases | R-HSA-8942233 | 3.627014e-01 | 0.440 | 0 | 0 |
| Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) | R-HSA-5619101 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 3.627014e-01 | 0.440 | 0 | 0 |
| XAV939 stabilizes AXIN | R-HSA-5545619 | 3.627014e-01 | 0.440 | 0 | 0 |
| TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | R-HSA-6791462 | 3.627014e-01 | 0.440 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 3.627014e-01 | 0.440 | 0 | 0 |
| Signaling by kinase domain mutants of KIT | R-HSA-9669933 | 3.627014e-01 | 0.440 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 3.627014e-01 | 0.440 | 0 | 0 |
| MyD88 deficiency (TLR5) | R-HSA-5602680 | 3.627014e-01 | 0.440 | 0 | 0 |
| Defective GFPT1 causes CMSTA1 | R-HSA-4085023 | 3.627014e-01 | 0.440 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.915119e-01 | 0.718 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose | R-HSA-9031528 | 1.915119e-01 | 0.718 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 1.915119e-01 | 0.718 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 1.915119e-01 | 0.718 | 0 | 0 |
| IRS activation | R-HSA-74713 | 2.830390e-01 | 0.548 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 2.830390e-01 | 0.548 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 2.830390e-01 | 0.548 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 2.300641e-01 | 0.638 | 0 | 0 |
| RSK activation | R-HSA-444257 | 2.300641e-01 | 0.638 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 2.300641e-01 | 0.638 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 1.851650e-01 | 0.732 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 2.217447e-01 | 0.654 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 2.217447e-01 | 0.654 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 2.698680e-01 | 0.569 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 2.698680e-01 | 0.569 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 2.698680e-01 | 0.569 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 3.378486e-01 | 0.471 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 3.378486e-01 | 0.471 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 3.378486e-01 | 0.471 | 0 | 0 |
| RUNX3 regulates RUNX1-mediated transcription | R-HSA-8951911 | 4.515768e-01 | 0.345 | 0 | 0 |
| Interaction between PHLDA1 and AURKA | R-HSA-8854521 | 4.515768e-01 | 0.345 | 0 | 0 |
| HHAT G278V doesn't palmitoylate Hh-Np | R-HSA-5658034 | 4.515768e-01 | 0.345 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 4.515768e-01 | 0.345 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 4.515768e-01 | 0.345 | 0 | 0 |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | R-HSA-5655799 | 4.515768e-01 | 0.345 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 4.515768e-01 | 0.345 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 4.515768e-01 | 0.345 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 4.515768e-01 | 0.345 | 0 | 0 |
| Mitotic Metaphase/Anaphase Transition | R-HSA-68881 | 4.515768e-01 | 0.345 | 0 | 0 |
| TWIK related potassium channel (TREK) | R-HSA-1299503 | 4.515768e-01 | 0.345 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 2.110273e-01 | 0.676 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.110273e-01 | 0.676 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.110273e-01 | 0.676 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 2.536935e-01 | 0.596 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 2.536935e-01 | 0.596 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 2.536935e-01 | 0.596 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 3.103445e-01 | 0.508 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 3.103445e-01 | 0.508 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 3.103445e-01 | 0.508 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 3.103445e-01 | 0.508 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 3.103445e-01 | 0.508 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 3.913184e-01 | 0.407 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 3.913184e-01 | 0.407 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in WNT signaling | R-HSA-8939256 | 3.913184e-01 | 0.407 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 3.913184e-01 | 0.407 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 3.913184e-01 | 0.407 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 2.657588e-01 | 0.576 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 1.972542e-01 | 0.705 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 3.509792e-01 | 0.455 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 3.509792e-01 | 0.455 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 3.509792e-01 | 0.455 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 3.509792e-01 | 0.455 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 3.509792e-01 | 0.455 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 2.311439e-01 | 0.636 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 3.198570e-01 | 0.495 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 2.723537e-01 | 0.565 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 2.362814e-01 | 0.627 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 1.975528e-01 | 0.704 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 2.242330e-01 | 0.649 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 2.759315e-01 | 0.559 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 2.978023e-01 | 0.526 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 3.534781e-01 | 0.452 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 3.534781e-01 | 0.452 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 3.534781e-01 | 0.452 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 3.534781e-01 | 0.452 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 3.913257e-01 | 0.407 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 3.913257e-01 | 0.407 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 3.913257e-01 | 0.407 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 3.913257e-01 | 0.407 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 3.913257e-01 | 0.407 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 4.427566e-01 | 0.354 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 4.427566e-01 | 0.354 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 4.427566e-01 | 0.354 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 4.427566e-01 | 0.354 | 0 | 0 |
| The NLRP1 inflammasome | R-HSA-844455 | 5.280623e-01 | 0.277 | 0 | 0 |
| Defective MMACHC causes MAHCC | R-HSA-3359474 | 5.280623e-01 | 0.277 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of other transcription factors | R-HSA-8866906 | 5.280623e-01 | 0.277 | 0 | 0 |
| Axonal growth stimulation | R-HSA-209563 | 5.280623e-01 | 0.277 | 0 | 0 |
| Invadopodia formation | R-HSA-8941237 | 5.280623e-01 | 0.277 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 5.280623e-01 | 0.277 | 0 | 0 |
| Defective ABCA1 causes TGD | R-HSA-5682113 | 5.280623e-01 | 0.277 | 0 | 0 |
| IRAK4 deficiency (TLR5) | R-HSA-5603037 | 5.280623e-01 | 0.277 | 0 | 0 |
| Defective GCLC causes HAGGSD | R-HSA-5578999 | 5.280623e-01 | 0.277 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 5.280623e-01 | 0.277 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 2.124000e-01 | 0.673 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 2.776801e-01 | 0.556 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 2.776801e-01 | 0.556 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 3.236775e-01 | 0.490 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 3.236775e-01 | 0.490 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 3.524228e-01 | 0.453 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.284554e-01 | 0.641 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 3.870980e-01 | 0.412 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 3.870980e-01 | 0.412 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 3.498452e-01 | 0.456 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 4.310053e-01 | 0.366 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 4.310053e-01 | 0.366 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 4.310053e-01 | 0.366 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 4.310053e-01 | 0.366 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 4.310053e-01 | 0.366 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 4.310053e-01 | 0.366 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 3.817743e-01 | 0.418 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 3.465373e-01 | 0.460 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 2.745554e-01 | 0.561 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 1.895095e-01 | 0.722 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 3.761753e-01 | 0.425 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 3.761753e-01 | 0.425 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 4.204771e-01 | 0.376 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 4.204771e-01 | 0.376 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 4.916900e-01 | 0.308 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 4.916900e-01 | 0.308 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 4.916900e-01 | 0.308 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 4.916900e-01 | 0.308 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 4.916900e-01 | 0.308 | 0 | 0 |
| Activation of RAS in B cells | R-HSA-1169092 | 4.916900e-01 | 0.308 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 4.916900e-01 | 0.308 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 4.110695e-01 | 0.386 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 2.831605e-01 | 0.548 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 4.025435e-01 | 0.395 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 4.025435e-01 | 0.395 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 4.697043e-01 | 0.328 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 4.697043e-01 | 0.328 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 3.874543e-01 | 0.412 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 4.534021e-01 | 0.344 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 4.288321e-01 | 0.368 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 4.288321e-01 | 0.368 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 3.569629e-01 | 0.447 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 4.188486e-01 | 0.378 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 4.188486e-01 | 0.378 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 4.098570e-01 | 0.387 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 4.098570e-01 | 0.387 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 4.098570e-01 | 0.387 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 4.098570e-01 | 0.387 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 3.504431e-01 | 0.455 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 4.549313e-01 | 0.342 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 4.688872e-01 | 0.329 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.688872e-01 | 0.329 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 4.688872e-01 | 0.329 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 4.856867e-01 | 0.314 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 5.071697e-01 | 0.295 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 5.071697e-01 | 0.295 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 5.378171e-01 | 0.269 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 5.378171e-01 | 0.269 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 4.336577e-01 | 0.363 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 4.807395e-01 | 0.318 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 4.534190e-01 | 0.344 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 4.426968e-01 | 0.354 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 4.257542e-01 | 0.371 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 4.335373e-01 | 0.363 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 5.171716e-01 | 0.286 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 4.254351e-01 | 0.371 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 4.621159e-01 | 0.335 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 4.040821e-01 | 0.394 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 4.926044e-01 | 0.308 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 4.463229e-01 | 0.350 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 4.651017e-01 | 0.332 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 5.101954e-01 | 0.292 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 5.365805e-01 | 0.270 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 3.608075e-01 | 0.443 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 4.698616e-01 | 0.328 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 3.466516e-01 | 0.460 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 3.281898e-01 | 0.484 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 4.907451e-01 | 0.309 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 4.204771e-01 | 0.376 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 4.204771e-01 | 0.376 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 4.869099e-01 | 0.313 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 2.905666e-01 | 0.537 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 4.926044e-01 | 0.308 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 2.881743e-01 | 0.540 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 3.006298e-01 | 0.522 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 2.782468e-01 | 0.556 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 2.782468e-01 | 0.556 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.985348e-01 | 0.302 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 4.549313e-01 | 0.342 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 3.262420e-01 | 0.486 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 4.903779e-01 | 0.309 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 4.869099e-01 | 0.313 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 5.160260e-01 | 0.287 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 2.698680e-01 | 0.569 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 2.164341e-01 | 0.665 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 3.870980e-01 | 0.412 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 1.895095e-01 | 0.722 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 5.414381e-01 | 0.266 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 2.097378e-01 | 0.678 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 3.400788e-01 | 0.468 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 2.595568e-01 | 0.586 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 1.999341e-01 | 0.699 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 3.913184e-01 | 0.407 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 2.097378e-01 | 0.678 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 4.428911e-01 | 0.354 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 3.198570e-01 | 0.495 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 3.466280e-01 | 0.460 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 3.329335e-01 | 0.478 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 3.068466e-01 | 0.513 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 2.698680e-01 | 0.569 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 3.103445e-01 | 0.508 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 5.311217e-01 | 0.275 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 5.310539e-01 | 0.275 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 5.053451e-01 | 0.296 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 5.228369e-01 | 0.282 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 5.228369e-01 | 0.282 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 2.565935e-01 | 0.591 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 3.870980e-01 | 0.412 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 4.807395e-01 | 0.318 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 3.465373e-01 | 0.460 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 3.236775e-01 | 0.490 | 0 | 0 |
| Formation of lateral plate mesoderm | R-HSA-9758920 | 3.378486e-01 | 0.471 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 2.776801e-01 | 0.556 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 4.110695e-01 | 0.386 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 3.650984e-01 | 0.438 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 4.697043e-01 | 0.328 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 2.944259e-01 | 0.531 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 5.378171e-01 | 0.269 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 4.257542e-01 | 0.371 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 5.171716e-01 | 0.286 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 3.195421e-01 | 0.495 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 2.657588e-01 | 0.576 | 0 | 0 |
| S Phase | R-HSA-69242 | 2.938520e-01 | 0.532 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 2.365554e-01 | 0.626 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 2.698680e-01 | 0.569 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 3.608075e-01 | 0.443 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 3.869388e-01 | 0.412 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 2.136155e-01 | 0.670 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 2.300641e-01 | 0.638 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 2.698680e-01 | 0.569 | 0 | 0 |
| PKA activation | R-HSA-163615 | 2.657588e-01 | 0.576 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 2.164341e-01 | 0.665 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 3.913257e-01 | 0.407 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 4.310053e-01 | 0.366 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 4.916900e-01 | 0.308 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 4.916900e-01 | 0.308 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 3.910953e-01 | 0.408 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 5.378171e-01 | 0.269 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 3.693641e-01 | 0.433 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 5.171716e-01 | 0.286 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 4.407011e-01 | 0.356 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 4.395398e-01 | 0.357 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 4.383255e-01 | 0.358 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 3.638689e-01 | 0.439 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 2.136155e-01 | 0.670 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 2.136155e-01 | 0.670 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 3.509792e-01 | 0.455 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.946650e-01 | 0.531 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 3.705811e-01 | 0.431 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 4.383255e-01 | 0.358 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 4.784579e-01 | 0.320 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 3.534781e-01 | 0.452 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 3.802752e-01 | 0.420 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 5.248089e-01 | 0.280 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.946650e-01 | 0.531 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 3.504431e-01 | 0.455 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 2.217447e-01 | 0.654 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 2.759315e-01 | 0.559 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 3.524228e-01 | 0.453 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 3.184677e-01 | 0.497 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 4.784579e-01 | 0.320 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 2.350515e-01 | 0.629 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 4.505259e-01 | 0.346 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 2.782468e-01 | 0.556 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 3.103445e-01 | 0.508 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 4.807692e-01 | 0.318 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 1.857352e-01 | 0.731 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 5.211142e-01 | 0.283 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 1.857352e-01 | 0.731 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 2.434687e-01 | 0.614 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 2.913786e-01 | 0.536 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 4.183431e-01 | 0.378 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 3.378486e-01 | 0.471 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 2.864997e-01 | 0.543 | 0 | 0 |
| Abacavir transmembrane transport | R-HSA-2161517 | 3.913184e-01 | 0.407 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 4.427566e-01 | 0.354 | 0 | 0 |
| Ca2+ activated K+ channels | R-HSA-1296052 | 4.427566e-01 | 0.354 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 2.991120e-01 | 0.524 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 4.916900e-01 | 0.308 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 4.916900e-01 | 0.308 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 4.916900e-01 | 0.308 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 4.916900e-01 | 0.308 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 4.697043e-01 | 0.328 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 3.504431e-01 | 0.455 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 5.378171e-01 | 0.269 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 4.971427e-01 | 0.304 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 2.729162e-01 | 0.564 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 2.198664e-01 | 0.658 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 5.401390e-01 | 0.267 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 1.917672e-01 | 0.717 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 4.549313e-01 | 0.342 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 4.281455e-01 | 0.368 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 2.424740e-01 | 0.615 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 3.910953e-01 | 0.408 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 1.915119e-01 | 0.718 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 4.697043e-01 | 0.328 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 2.897545e-01 | 0.538 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 3.272368e-01 | 0.485 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 3.272368e-01 | 0.485 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 3.272368e-01 | 0.485 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 3.272368e-01 | 0.485 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 4.677276e-01 | 0.330 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 3.198570e-01 | 0.495 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 3.705811e-01 | 0.431 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 2.849926e-01 | 0.545 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 3.184677e-01 | 0.497 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 2.809457e-01 | 0.551 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 3.524671e-01 | 0.453 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 5.320616e-01 | 0.274 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 1.909726e-01 | 0.719 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 3.870980e-01 | 0.412 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 4.730829e-01 | 0.325 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 3.947158e-01 | 0.404 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 4.105405e-01 | 0.387 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 4.258137e-01 | 0.371 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 3.208311e-01 | 0.494 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 3.705811e-01 | 0.431 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 2.471606e-01 | 0.607 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 2.594302e-01 | 0.586 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 2.278586e-01 | 0.642 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 1.915119e-01 | 0.718 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 2.300641e-01 | 0.638 | 0 | 0 |
| Co-stimulation by ICOS | R-HSA-9927354 | 2.300641e-01 | 0.638 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 1.909726e-01 | 0.719 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 1.909726e-01 | 0.719 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 1.851650e-01 | 0.732 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 2.698680e-01 | 0.569 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 2.698680e-01 | 0.569 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 3.378486e-01 | 0.471 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 4.515768e-01 | 0.345 | 0 | 0 |
| Defective ABCC8 can cause hypo- and hyper-glycemias | R-HSA-5683177 | 4.515768e-01 | 0.345 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 1.891194e-01 | 0.723 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 2.864997e-01 | 0.543 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 2.657588e-01 | 0.576 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 3.509792e-01 | 0.455 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 3.231825e-01 | 0.491 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 5.280623e-01 | 0.277 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 5.280623e-01 | 0.277 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 3.524228e-01 | 0.453 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 3.870980e-01 | 0.412 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 3.498452e-01 | 0.456 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 3.498452e-01 | 0.456 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 4.697043e-01 | 0.328 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 4.534021e-01 | 0.344 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 4.288321e-01 | 0.368 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 4.288321e-01 | 0.368 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 4.644302e-01 | 0.333 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 4.950007e-01 | 0.305 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 3.037442e-01 | 0.517 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 2.595568e-01 | 0.586 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 2.710089e-01 | 0.567 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.401540e-01 | 0.356 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 2.532416e-01 | 0.596 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 3.844136e-01 | 0.415 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.110695e-01 | 0.386 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 5.378171e-01 | 0.269 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 1.891194e-01 | 0.723 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 3.750917e-01 | 0.426 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 3.981803e-01 | 0.400 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 2.830390e-01 | 0.548 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 2.698680e-01 | 0.569 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 2.536935e-01 | 0.596 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 3.913184e-01 | 0.407 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 4.427566e-01 | 0.354 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 2.596522e-01 | 0.586 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 4.310053e-01 | 0.366 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 4.310053e-01 | 0.366 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 4.310053e-01 | 0.366 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 4.204771e-01 | 0.376 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 4.016354e-01 | 0.396 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 3.372654e-01 | 0.472 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 1.915702e-01 | 0.718 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 4.038940e-01 | 0.394 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 3.150543e-01 | 0.502 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 4.395398e-01 | 0.357 | 1 | 1 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 3.761753e-01 | 0.425 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 2.657588e-01 | 0.576 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 3.272368e-01 | 0.485 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 4.310053e-01 | 0.366 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 3.378486e-01 | 0.471 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 4.515768e-01 | 0.345 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 2.536935e-01 | 0.596 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 3.103445e-01 | 0.508 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 3.509792e-01 | 0.455 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 3.198570e-01 | 0.495 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 2.242330e-01 | 0.649 | 0 | 0 |
| CASP5-mediated substrate cleavage | R-HSA-9960525 | 5.280623e-01 | 0.277 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 3.705811e-01 | 0.431 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 3.546027e-01 | 0.450 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 3.371282e-01 | 0.472 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 4.688872e-01 | 0.329 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 5.378171e-01 | 0.269 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 4.534190e-01 | 0.344 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 3.371282e-01 | 0.472 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 2.097378e-01 | 0.678 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.697043e-01 | 0.328 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 2.942319e-01 | 0.531 | 0 | 0 |
| Histamine receptors | R-HSA-390650 | 5.280623e-01 | 0.277 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 5.378171e-01 | 0.269 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 4.549313e-01 | 0.342 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 2.300641e-01 | 0.638 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 4.515768e-01 | 0.345 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 4.427566e-01 | 0.354 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in metabolism | R-HSA-9854907 | 5.280623e-01 | 0.277 | 0 | 0 |
| CASP4-mediated substrate cleavage | R-HSA-9960519 | 5.280623e-01 | 0.277 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 2.949191e-01 | 0.530 | 0 | 0 |
| Interleukin-18 signaling | R-HSA-9012546 | 4.916900e-01 | 0.308 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 4.188486e-01 | 0.378 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 3.534781e-01 | 0.452 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 2.425261e-01 | 0.615 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 3.236775e-01 | 0.490 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 2.864997e-01 | 0.543 | 0 | 0 |
| FasL/ CD95L signaling | R-HSA-75157 | 5.280623e-01 | 0.277 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 5.378171e-01 | 0.269 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 3.371029e-01 | 0.472 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 4.534021e-01 | 0.344 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 3.568660e-01 | 0.447 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 4.697043e-01 | 0.328 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 3.103445e-01 | 0.508 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 3.883970e-01 | 0.411 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 4.489622e-01 | 0.348 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 4.254351e-01 | 0.371 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 5.432038e-01 | 0.265 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 5.432038e-01 | 0.265 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 5.432038e-01 | 0.265 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 5.432038e-01 | 0.265 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 5.432038e-01 | 0.265 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 5.432038e-01 | 0.265 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 5.432038e-01 | 0.265 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 5.432038e-01 | 0.265 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 5.432038e-01 | 0.265 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 5.458466e-01 | 0.263 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 5.477229e-01 | 0.261 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 5.477229e-01 | 0.261 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 5.477229e-01 | 0.261 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 5.477229e-01 | 0.261 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 5.477229e-01 | 0.261 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 5.499048e-01 | 0.260 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 5.499048e-01 | 0.260 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 5.508475e-01 | 0.259 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 5.517889e-01 | 0.258 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 5.541427e-01 | 0.256 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 5.555381e-01 | 0.255 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 5.555381e-01 | 0.255 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 5.590409e-01 | 0.253 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 5.590409e-01 | 0.253 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 5.590409e-01 | 0.253 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 5.602462e-01 | 0.252 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 5.605696e-01 | 0.251 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 5.623422e-01 | 0.250 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 5.631326e-01 | 0.249 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 5.652118e-01 | 0.248 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 5.740644e-01 | 0.241 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 5.772314e-01 | 0.239 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 5.772314e-01 | 0.239 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 5.772314e-01 | 0.239 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 5.772314e-01 | 0.239 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 5.772314e-01 | 0.239 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 5.772314e-01 | 0.239 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 5.776586e-01 | 0.238 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 5.776586e-01 | 0.238 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 5.776586e-01 | 0.238 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 5.776586e-01 | 0.238 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 5.776586e-01 | 0.238 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 5.779999e-01 | 0.238 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 5.779999e-01 | 0.238 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 5.779999e-01 | 0.238 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 5.779999e-01 | 0.238 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 5.779999e-01 | 0.238 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 5.793483e-01 | 0.237 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 5.809689e-01 | 0.236 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 5.809689e-01 | 0.236 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 5.809689e-01 | 0.236 | 0 | 0 |
| TET1,2,3 and TDG demethylate DNA | R-HSA-5221030 | 5.809689e-01 | 0.236 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 5.809689e-01 | 0.236 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 5.809689e-01 | 0.236 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 5.809689e-01 | 0.236 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 5.810018e-01 | 0.236 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 5.810018e-01 | 0.236 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 5.817393e-01 | 0.235 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 5.828216e-01 | 0.234 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 5.828216e-01 | 0.234 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 5.866872e-01 | 0.232 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 5.866872e-01 | 0.232 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.886289e-01 | 0.230 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 5.886614e-01 | 0.230 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 5.906376e-01 | 0.229 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 5.909461e-01 | 0.228 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 5.938846e-01 | 0.226 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 5.938846e-01 | 0.226 | 0 | 0 |
| ATP sensitive Potassium channels | R-HSA-1296025 | 5.938846e-01 | 0.226 | 0 | 0 |
| Signaling by MAP2K mutants | R-HSA-9652169 | 5.938846e-01 | 0.226 | 0 | 0 |
| Defective MAT1A causes MATD | R-HSA-5579024 | 5.938846e-01 | 0.226 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 5.938846e-01 | 0.226 | 0 | 0 |
| Alanine metabolism | R-HSA-8964540 | 5.938846e-01 | 0.226 | 0 | 0 |
| Electric Transmission Across Gap Junctions | R-HSA-112303 | 5.938846e-01 | 0.226 | 0 | 0 |
| Transmission across Electrical Synapses | R-HSA-112307 | 5.938846e-01 | 0.226 | 0 | 0 |
| MDK and PTN in ALK signaling | R-HSA-9851151 | 5.938846e-01 | 0.226 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 5.938846e-01 | 0.226 | 0 | 0 |
| Sensory perception of sour taste | R-HSA-9729555 | 5.938846e-01 | 0.226 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 5.938846e-01 | 0.226 | 0 | 0 |
| Regulation of HMOX1 expression and activity | R-HSA-9707587 | 5.938846e-01 | 0.226 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 5.966730e-01 | 0.224 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 5.980343e-01 | 0.223 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 6.007079e-01 | 0.221 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 6.024171e-01 | 0.220 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 6.024171e-01 | 0.220 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 6.024171e-01 | 0.220 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 6.028376e-01 | 0.220 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 6.031756e-01 | 0.220 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 6.033729e-01 | 0.219 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 6.033729e-01 | 0.219 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 6.033729e-01 | 0.219 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 6.033729e-01 | 0.219 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 6.033729e-01 | 0.219 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 6.056110e-01 | 0.218 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 6.104299e-01 | 0.214 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 6.104299e-01 | 0.214 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 6.104299e-01 | 0.214 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 6.104299e-01 | 0.214 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 6.104299e-01 | 0.214 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 6.104299e-01 | 0.214 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 6.110095e-01 | 0.214 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 6.124432e-01 | 0.213 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 6.124432e-01 | 0.213 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 6.168247e-01 | 0.210 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 6.188641e-01 | 0.208 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 6.210780e-01 | 0.207 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 6.210780e-01 | 0.207 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 6.210780e-01 | 0.207 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 6.210780e-01 | 0.207 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 6.220091e-01 | 0.206 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 6.220091e-01 | 0.206 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 6.220473e-01 | 0.206 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 6.220473e-01 | 0.206 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 6.223560e-01 | 0.206 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 6.223560e-01 | 0.206 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 6.249356e-01 | 0.204 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 6.249356e-01 | 0.204 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 6.249356e-01 | 0.204 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 6.249356e-01 | 0.204 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 6.249356e-01 | 0.204 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 6.278522e-01 | 0.202 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 6.278522e-01 | 0.202 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 6.278522e-01 | 0.202 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 6.278522e-01 | 0.202 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.327963e-01 | 0.199 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 6.327963e-01 | 0.199 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 6.391314e-01 | 0.194 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 6.398418e-01 | 0.194 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 6.399735e-01 | 0.194 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 6.399735e-01 | 0.194 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 6.413474e-01 | 0.193 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 6.414514e-01 | 0.193 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 6.414514e-01 | 0.193 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 6.466269e-01 | 0.189 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 6.466269e-01 | 0.189 | 0 | 0 |
| NFE2L2 regulating TCA cycle genes | R-HSA-9818025 | 6.505298e-01 | 0.187 | 0 | 0 |
| NOSIP mediated eNOS trafficking | R-HSA-203754 | 6.505298e-01 | 0.187 | 0 | 0 |
| Defective SLC1A3 causes episodic ataxia 6 (EA6) | R-HSA-5619062 | 6.505298e-01 | 0.187 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 6.505298e-01 | 0.187 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 6.505298e-01 | 0.187 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 6.505298e-01 | 0.187 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 6.505298e-01 | 0.187 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 6.505298e-01 | 0.187 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 6.505298e-01 | 0.187 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 6.505298e-01 | 0.187 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in interleukin signaling | R-HSA-8939247 | 6.505298e-01 | 0.187 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 6.505298e-01 | 0.187 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 6.505298e-01 | 0.187 | 0 | 0 |
| Biosynthesis of DPAn-3-derived 13-series resolvins | R-HSA-9026403 | 6.505298e-01 | 0.187 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 6.505298e-01 | 0.187 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 6.513939e-01 | 0.186 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 6.513939e-01 | 0.186 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 6.513939e-01 | 0.186 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 6.513939e-01 | 0.186 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 6.574572e-01 | 0.182 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 6.580091e-01 | 0.182 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 6.581537e-01 | 0.182 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 6.581537e-01 | 0.182 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 6.581537e-01 | 0.182 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 6.581537e-01 | 0.182 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 6.581537e-01 | 0.182 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 6.581537e-01 | 0.182 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 6.581537e-01 | 0.182 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 6.587413e-01 | 0.181 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 6.587413e-01 | 0.181 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 6.587413e-01 | 0.181 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 6.597866e-01 | 0.181 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 6.630215e-01 | 0.178 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 6.675400e-01 | 0.176 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 6.680585e-01 | 0.175 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.701624e-01 | 0.174 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 6.706892e-01 | 0.173 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 6.706892e-01 | 0.173 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 6.776530e-01 | 0.169 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 6.782246e-01 | 0.169 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 6.834170e-01 | 0.165 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 6.852924e-01 | 0.164 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 6.852924e-01 | 0.164 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 6.889279e-01 | 0.162 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 6.890630e-01 | 0.162 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 6.907290e-01 | 0.161 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 6.922617e-01 | 0.160 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 6.922617e-01 | 0.160 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 6.922617e-01 | 0.160 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 6.922617e-01 | 0.160 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 6.922617e-01 | 0.160 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 6.922617e-01 | 0.160 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 6.922617e-01 | 0.160 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 6.922617e-01 | 0.160 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 6.922617e-01 | 0.160 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 6.922617e-01 | 0.160 | 0 | 0 |
| Estrogen biosynthesis | R-HSA-193144 | 6.922617e-01 | 0.160 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 6.922617e-01 | 0.160 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 6.949301e-01 | 0.158 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 6.949301e-01 | 0.158 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 6.955467e-01 | 0.158 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 6.955467e-01 | 0.158 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 6.955467e-01 | 0.158 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 6.981369e-01 | 0.156 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 6.981369e-01 | 0.156 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 6.981369e-01 | 0.156 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 6.981369e-01 | 0.156 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 6.981369e-01 | 0.156 | 0 | 0 |
| Plus-strand DNA synthesis | R-HSA-164525 | 6.992769e-01 | 0.155 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 6.992769e-01 | 0.155 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 6.992769e-01 | 0.155 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 6.992769e-01 | 0.155 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 6.992769e-01 | 0.155 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 6.992769e-01 | 0.155 | 0 | 0 |
| Phase 1 - inactivation of fast Na+ channels | R-HSA-5576894 | 6.992769e-01 | 0.155 | 0 | 0 |
| Defective CSF2RA causes SMDP4 | R-HSA-5688890 | 6.992769e-01 | 0.155 | 0 | 0 |
| Defective CSF2RB causes SMDP5 | R-HSA-5688849 | 6.992769e-01 | 0.155 | 0 | 0 |
| Signaling by RNF43 mutants | R-HSA-5340588 | 6.992769e-01 | 0.155 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 6.992769e-01 | 0.155 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 6.992769e-01 | 0.155 | 0 | 0 |
| NGF-independant TRKA activation | R-HSA-187024 | 6.992769e-01 | 0.155 | 0 | 0 |
| Formation of the Editosome | R-HSA-75094 | 6.992769e-01 | 0.155 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 6.992769e-01 | 0.155 | 0 | 0 |
| Synthesis of PS | R-HSA-1483101 | 6.992769e-01 | 0.155 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 6.992769e-01 | 0.155 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 6.992769e-01 | 0.155 | 0 | 0 |
| Release of Hh-Np from the secreting cell | R-HSA-5362798 | 6.992769e-01 | 0.155 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 6.992769e-01 | 0.155 | 0 | 0 |
| Acetylcholine inhibits contraction of outer hair cells | R-HSA-9667769 | 6.992769e-01 | 0.155 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 6.992769e-01 | 0.155 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 6.992769e-01 | 0.155 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 6.992769e-01 | 0.155 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 6.992769e-01 | 0.155 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 7.001241e-01 | 0.155 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 7.001241e-01 | 0.155 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 7.001241e-01 | 0.155 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 7.001241e-01 | 0.155 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 7.068098e-01 | 0.151 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 7.112101e-01 | 0.148 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 7.161237e-01 | 0.145 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 7.161237e-01 | 0.145 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 7.161237e-01 | 0.145 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 7.229004e-01 | 0.141 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 7.235086e-01 | 0.141 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 7.238105e-01 | 0.140 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 7.238105e-01 | 0.140 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 7.276693e-01 | 0.138 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 7.289191e-01 | 0.137 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 7.289191e-01 | 0.137 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 7.289191e-01 | 0.137 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 7.289191e-01 | 0.137 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 7.340730e-01 | 0.134 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 7.344382e-01 | 0.134 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 7.344382e-01 | 0.134 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 7.356932e-01 | 0.133 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 7.356932e-01 | 0.133 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 7.356932e-01 | 0.133 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 7.356932e-01 | 0.133 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 7.371140e-01 | 0.132 | 0 | 0 |
| Immune System | R-HSA-168256 | 7.373697e-01 | 0.132 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 7.410156e-01 | 0.130 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 7.412267e-01 | 0.130 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 7.412267e-01 | 0.130 | 0 | 0 |
| Uncoating of the HIV Virion | R-HSA-162585 | 7.412267e-01 | 0.130 | 0 | 0 |
| Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | R-HSA-629587 | 7.412267e-01 | 0.130 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 7.412267e-01 | 0.130 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 7.412267e-01 | 0.130 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 7.412267e-01 | 0.130 | 0 | 0 |
| Hydrolysis of LPE | R-HSA-1483152 | 7.412267e-01 | 0.130 | 0 | 0 |
| NADPH regeneration | R-HSA-389542 | 7.412267e-01 | 0.130 | 0 | 0 |
| Lipid particle organization | R-HSA-8964572 | 7.412267e-01 | 0.130 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 7.430478e-01 | 0.129 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 7.430478e-01 | 0.129 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.430478e-01 | 0.129 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 7.441611e-01 | 0.128 | 1 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 7.477444e-01 | 0.126 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 7.477444e-01 | 0.126 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 7.497559e-01 | 0.125 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 7.497559e-01 | 0.125 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 7.505338e-01 | 0.125 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 7.514254e-01 | 0.124 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 7.520288e-01 | 0.124 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 7.520288e-01 | 0.124 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 7.520288e-01 | 0.124 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 7.520288e-01 | 0.124 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 7.520288e-01 | 0.124 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 7.542591e-01 | 0.122 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 7.542591e-01 | 0.122 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 7.542591e-01 | 0.122 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 7.552082e-01 | 0.122 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 7.593662e-01 | 0.120 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 7.659214e-01 | 0.116 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 7.699877e-01 | 0.114 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 7.718317e-01 | 0.112 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 7.738770e-01 | 0.111 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 7.742053e-01 | 0.111 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 7.750062e-01 | 0.111 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 7.773268e-01 | 0.109 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 7.773268e-01 | 0.109 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 7.773268e-01 | 0.109 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 7.773268e-01 | 0.109 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 7.773268e-01 | 0.109 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | R-HSA-9632974 | 7.773268e-01 | 0.109 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | R-HSA-9031525 | 7.773268e-01 | 0.109 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 7.773268e-01 | 0.109 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 7.773268e-01 | 0.109 | 0 | 0 |
| mRNA Editing: C to U Conversion | R-HSA-72200 | 7.773268e-01 | 0.109 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 7.773268e-01 | 0.109 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 7.773268e-01 | 0.109 | 0 | 0 |
| Synthesis of PIPs in the nucleus | R-HSA-8847453 | 7.773268e-01 | 0.109 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 7.773268e-01 | 0.109 | 0 | 0 |
| Activation of TRKA receptors | R-HSA-187015 | 7.773268e-01 | 0.109 | 0 | 0 |
| Glycoprotein hormones | R-HSA-209822 | 7.773268e-01 | 0.109 | 0 | 0 |
| Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | R-HSA-9026762 | 7.773268e-01 | 0.109 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 7.773268e-01 | 0.109 | 0 | 0 |
| Maturation of replicase proteins | R-HSA-9694301 | 7.773268e-01 | 0.109 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 7.779748e-01 | 0.109 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 7.779748e-01 | 0.109 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 7.779748e-01 | 0.109 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 7.779748e-01 | 0.109 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 7.790006e-01 | 0.108 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 7.801072e-01 | 0.108 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 7.857537e-01 | 0.105 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 7.857537e-01 | 0.105 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 7.877021e-01 | 0.104 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 7.906008e-01 | 0.102 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 7.906008e-01 | 0.102 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 7.906008e-01 | 0.102 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 7.906008e-01 | 0.102 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 7.910057e-01 | 0.102 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 7.910057e-01 | 0.102 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 7.910057e-01 | 0.102 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 7.910684e-01 | 0.102 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 7.945932e-01 | 0.100 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 7.945932e-01 | 0.100 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 7.945932e-01 | 0.100 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 7.964258e-01 | 0.099 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.015098e-01 | 0.096 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 8.015098e-01 | 0.096 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 8.015098e-01 | 0.096 | 0 | 0 |
| Serotonin and melatonin biosynthesis | R-HSA-209931 | 8.015098e-01 | 0.096 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.015098e-01 | 0.096 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 8.015098e-01 | 0.096 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 8.017522e-01 | 0.096 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.040668e-01 | 0.095 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 8.053763e-01 | 0.094 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 8.053763e-01 | 0.094 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 8.053763e-01 | 0.094 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 8.053763e-01 | 0.094 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 8.078952e-01 | 0.093 | 0 | 0 |
| Reverse Transcription of HIV RNA | R-HSA-162589 | 8.083925e-01 | 0.092 | 0 | 0 |
| Minus-strand DNA synthesis | R-HSA-164516 | 8.083925e-01 | 0.092 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 8.083925e-01 | 0.092 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 8.083925e-01 | 0.092 | 0 | 0 |
| Interleukin-9 signaling | R-HSA-8985947 | 8.083925e-01 | 0.092 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 8.083925e-01 | 0.092 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 8.083925e-01 | 0.092 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 8.083925e-01 | 0.092 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 8.083925e-01 | 0.092 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 8.083925e-01 | 0.092 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 8.096525e-01 | 0.092 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 8.096525e-01 | 0.092 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 8.152889e-01 | 0.089 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 8.206240e-01 | 0.086 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 8.209016e-01 | 0.086 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 8.209016e-01 | 0.086 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 8.223497e-01 | 0.085 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 8.228012e-01 | 0.085 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 8.228012e-01 | 0.085 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 8.228012e-01 | 0.085 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.228012e-01 | 0.085 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.228012e-01 | 0.085 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 8.228012e-01 | 0.085 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 8.228012e-01 | 0.085 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 8.228012e-01 | 0.085 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 8.229256e-01 | 0.085 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.229256e-01 | 0.085 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 8.236271e-01 | 0.084 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 8.272175e-01 | 0.082 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 8.299974e-01 | 0.081 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 8.317925e-01 | 0.080 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 8.317925e-01 | 0.080 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 8.324952e-01 | 0.080 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 8.325820e-01 | 0.080 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 8.325820e-01 | 0.080 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.325820e-01 | 0.080 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 8.325820e-01 | 0.080 | 0 | 0 |
| Estrogen-stimulated signaling through PRKCZ | R-HSA-9634635 | 8.351257e-01 | 0.078 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 8.351257e-01 | 0.078 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 8.351257e-01 | 0.078 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 8.351257e-01 | 0.078 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 8.351257e-01 | 0.078 | 0 | 0 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 8.351257e-01 | 0.078 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 8.351257e-01 | 0.078 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 8.351257e-01 | 0.078 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 8.351257e-01 | 0.078 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 8.351257e-01 | 0.078 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 8.351257e-01 | 0.078 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 8.351257e-01 | 0.078 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 8.351257e-01 | 0.078 | 0 | 0 |
| Protein folding | R-HSA-391251 | 8.361631e-01 | 0.078 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 8.364062e-01 | 0.078 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 8.420013e-01 | 0.075 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 8.420170e-01 | 0.075 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.420170e-01 | 0.075 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 8.420170e-01 | 0.075 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 8.420170e-01 | 0.075 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.420170e-01 | 0.075 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 8.420170e-01 | 0.075 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 8.433744e-01 | 0.074 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 8.433744e-01 | 0.074 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 8.433744e-01 | 0.074 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 8.438248e-01 | 0.074 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 8.455174e-01 | 0.073 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 8.475521e-01 | 0.072 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 8.496928e-01 | 0.071 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 8.496928e-01 | 0.071 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 8.496928e-01 | 0.071 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 8.515528e-01 | 0.070 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 8.576153e-01 | 0.067 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 8.576153e-01 | 0.067 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 8.576153e-01 | 0.067 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 8.576153e-01 | 0.067 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 8.576153e-01 | 0.067 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 8.581304e-01 | 0.066 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 8.581304e-01 | 0.066 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 8.581304e-01 | 0.066 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 8.581304e-01 | 0.066 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 8.581304e-01 | 0.066 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 8.581304e-01 | 0.066 | 0 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 8.581304e-01 | 0.066 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 8.581304e-01 | 0.066 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 8.581304e-01 | 0.066 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 8.581304e-01 | 0.066 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 8.581304e-01 | 0.066 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 8.581304e-01 | 0.066 | 0 | 0 |
| Sperm Motility And Taxes | R-HSA-1300642 | 8.581304e-01 | 0.066 | 0 | 0 |
| Peptide hormone biosynthesis | R-HSA-209952 | 8.581304e-01 | 0.066 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 8.581759e-01 | 0.066 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 8.582041e-01 | 0.066 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 8.582041e-01 | 0.066 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 8.593218e-01 | 0.066 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 8.593218e-01 | 0.066 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.593218e-01 | 0.066 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 8.593218e-01 | 0.066 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 8.593218e-01 | 0.066 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.593218e-01 | 0.066 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 8.593218e-01 | 0.066 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.593218e-01 | 0.066 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 8.617377e-01 | 0.065 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 8.622438e-01 | 0.064 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 8.625555e-01 | 0.064 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 8.625555e-01 | 0.064 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 8.646344e-01 | 0.063 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 8.689104e-01 | 0.061 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 8.696516e-01 | 0.061 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 8.717880e-01 | 0.060 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 8.717880e-01 | 0.060 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 8.717880e-01 | 0.060 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 8.736829e-01 | 0.059 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 8.739256e-01 | 0.059 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 8.741547e-01 | 0.058 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 8.741547e-01 | 0.058 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 8.743322e-01 | 0.058 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 8.744636e-01 | 0.058 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 8.748746e-01 | 0.058 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.748746e-01 | 0.058 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 8.768642e-01 | 0.057 | 0 | 0 |
| Presynaptic depolarization and calcium channel opening | R-HSA-112308 | 8.779264e-01 | 0.057 | 0 | 0 |
| FGFR2b ligand binding and activation | R-HSA-190377 | 8.779264e-01 | 0.057 | 0 | 0 |
| FGFRL1 modulation of FGFR1 signaling | R-HSA-5658623 | 8.779264e-01 | 0.057 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 8.779264e-01 | 0.057 | 0 | 0 |
| Cholesterol biosynthesis via desmosterol | R-HSA-6807047 | 8.779264e-01 | 0.057 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 8.779264e-01 | 0.057 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 8.779264e-01 | 0.057 | 0 | 0 |
| Biosynthesis of DPAn-3-derived maresins | R-HSA-9026290 | 8.779264e-01 | 0.057 | 0 | 0 |
| Inorganic anion exchange by SLC26 transporters | R-HSA-427601 | 8.779264e-01 | 0.057 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 8.779264e-01 | 0.057 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 8.794387e-01 | 0.056 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 8.820577e-01 | 0.055 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 8.842071e-01 | 0.053 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 8.842071e-01 | 0.053 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 8.854688e-01 | 0.053 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 8.854688e-01 | 0.053 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 8.854688e-01 | 0.053 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 8.855720e-01 | 0.053 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 8.862191e-01 | 0.052 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.888274e-01 | 0.051 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.888274e-01 | 0.051 | 0 | 0 |
| Mitochondrial iron-sulfur cluster biogenesis | R-HSA-1362409 | 8.888274e-01 | 0.051 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 8.891524e-01 | 0.051 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 8.892278e-01 | 0.051 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 8.892369e-01 | 0.051 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 8.895527e-01 | 0.051 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 8.948863e-01 | 0.048 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | R-HSA-3772470 | 8.949612e-01 | 0.048 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 8.949612e-01 | 0.048 | 0 | 0 |
| Plasmalogen biosynthesis | R-HSA-75896 | 8.949612e-01 | 0.048 | 0 | 0 |
| Presynaptic nicotinic acetylcholine receptors | R-HSA-622323 | 8.949612e-01 | 0.048 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 8.949612e-01 | 0.048 | 0 | 0 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | R-HSA-113501 | 8.949612e-01 | 0.048 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 8.955409e-01 | 0.048 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 8.955409e-01 | 0.048 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 8.955409e-01 | 0.048 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 8.956225e-01 | 0.048 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 8.983416e-01 | 0.047 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 9.013237e-01 | 0.045 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 9.013237e-01 | 0.045 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 9.013237e-01 | 0.045 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 9.013237e-01 | 0.045 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 9.013237e-01 | 0.045 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 9.049757e-01 | 0.043 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 9.058667e-01 | 0.043 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 9.067897e-01 | 0.042 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 9.067897e-01 | 0.042 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 9.096196e-01 | 0.041 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 9.096196e-01 | 0.041 | 0 | 0 |
| Biosynthesis of DPAn-3-derived protectins and resolvins | R-HSA-9026286 | 9.096196e-01 | 0.041 | 0 | 0 |
| Diseases associated with surfactant metabolism | R-HSA-5687613 | 9.096196e-01 | 0.041 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 9.096196e-01 | 0.041 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 9.096196e-01 | 0.041 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 9.102303e-01 | 0.041 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 9.124983e-01 | 0.040 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 9.124983e-01 | 0.040 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 9.124983e-01 | 0.040 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 9.124983e-01 | 0.040 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 9.134934e-01 | 0.039 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 9.135783e-01 | 0.039 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.135783e-01 | 0.039 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.135783e-01 | 0.039 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 9.135783e-01 | 0.039 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 9.135783e-01 | 0.039 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 9.146174e-01 | 0.039 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 9.152593e-01 | 0.038 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.152593e-01 | 0.038 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 9.152593e-01 | 0.038 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 9.152593e-01 | 0.038 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.152593e-01 | 0.038 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.202627e-01 | 0.036 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.208805e-01 | 0.036 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 9.214791e-01 | 0.036 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 9.214791e-01 | 0.036 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 9.214791e-01 | 0.036 | 0 | 0 |
| FGFR2c ligand binding and activation | R-HSA-190375 | 9.222332e-01 | 0.035 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 9.222332e-01 | 0.035 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 9.222332e-01 | 0.035 | 0 | 0 |
| FGFR4 ligand binding and activation | R-HSA-190322 | 9.222332e-01 | 0.035 | 0 | 0 |
| Postsynaptic nicotinic acetylcholine receptors | R-HSA-622327 | 9.222332e-01 | 0.035 | 0 | 0 |
| Acetylcholine binding and downstream events | R-HSA-181431 | 9.222332e-01 | 0.035 | 0 | 0 |
| Signaling by activated point mutants of FGFR3 | R-HSA-1839130 | 9.222332e-01 | 0.035 | 0 | 0 |
| Chylomicron remodeling | R-HSA-8963901 | 9.222332e-01 | 0.035 | 0 | 0 |
| Mtb iron assimilation by chelation | R-HSA-1222449 | 9.222332e-01 | 0.035 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 9.222332e-01 | 0.035 | 0 | 0 |
| FGFR3 mutant receptor activation | R-HSA-2033514 | 9.222332e-01 | 0.035 | 0 | 0 |
| rRNA modification in the mitochondrion | R-HSA-6793080 | 9.222332e-01 | 0.035 | 0 | 0 |
| Acyl chain remodeling of DAG and TAG | R-HSA-1482883 | 9.222332e-01 | 0.035 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 9.222332e-01 | 0.035 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 9.222332e-01 | 0.035 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 9.222332e-01 | 0.035 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 9.224767e-01 | 0.035 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 9.224767e-01 | 0.035 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 9.224767e-01 | 0.035 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 9.224767e-01 | 0.035 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.224767e-01 | 0.035 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 9.224767e-01 | 0.035 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 9.262916e-01 | 0.033 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.262916e-01 | 0.033 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 9.269248e-01 | 0.033 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 9.285539e-01 | 0.032 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 9.287251e-01 | 0.032 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.287251e-01 | 0.032 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.298476e-01 | 0.032 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 9.313749e-01 | 0.031 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 9.313749e-01 | 0.031 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 9.313749e-01 | 0.031 | 0 | 0 |
| Biosynthesis of maresins | R-HSA-9018682 | 9.313749e-01 | 0.031 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.313749e-01 | 0.031 | 0 | 0 |
| Synthesis of UDP-N-acetyl-glucosamine | R-HSA-446210 | 9.313749e-01 | 0.031 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 9.315269e-01 | 0.031 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 9.330870e-01 | 0.030 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 9.330870e-01 | 0.030 | 0 | 0 |
| FGFR3c ligand binding and activation | R-HSA-190372 | 9.330870e-01 | 0.030 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 9.330870e-01 | 0.030 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 9.330870e-01 | 0.030 | 0 | 0 |
| Biosynthesis of E-series 18(R)-resolvins | R-HSA-9023661 | 9.330870e-01 | 0.030 | 0 | 0 |
| Vitamin B2 (riboflavin) metabolism | R-HSA-196843 | 9.330870e-01 | 0.030 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 9.330870e-01 | 0.030 | 0 | 0 |
| Prolactin receptor signaling | R-HSA-1170546 | 9.330870e-01 | 0.030 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 9.330870e-01 | 0.030 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 9.330870e-01 | 0.030 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 9.330870e-01 | 0.030 | 0 | 0 |
| Ciprofloxacin ADME | R-HSA-9793528 | 9.330870e-01 | 0.030 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 9.330870e-01 | 0.030 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 9.330870e-01 | 0.030 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 9.330870e-01 | 0.030 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 9.345622e-01 | 0.029 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 9.347315e-01 | 0.029 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 9.385343e-01 | 0.028 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.385343e-01 | 0.028 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 9.393002e-01 | 0.027 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.393002e-01 | 0.027 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.399129e-01 | 0.027 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 9.403022e-01 | 0.027 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.403347e-01 | 0.027 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.408538e-01 | 0.026 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.414326e-01 | 0.026 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.418735e-01 | 0.026 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 9.424265e-01 | 0.026 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 9.424265e-01 | 0.026 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 9.424265e-01 | 0.026 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 9.424265e-01 | 0.026 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 9.424265e-01 | 0.026 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 9.424265e-01 | 0.026 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 9.424265e-01 | 0.026 | 0 | 0 |
| FGFR3 ligand binding and activation | R-HSA-190239 | 9.424265e-01 | 0.026 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 9.424265e-01 | 0.026 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 9.424265e-01 | 0.026 | 0 | 0 |
| Dopamine clearance from the synaptic cleft | R-HSA-379401 | 9.424265e-01 | 0.026 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 9.424265e-01 | 0.026 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 9.426015e-01 | 0.026 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 9.448727e-01 | 0.025 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 9.448727e-01 | 0.025 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.448727e-01 | 0.025 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 9.451540e-01 | 0.024 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 9.456693e-01 | 0.024 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.457568e-01 | 0.024 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.463506e-01 | 0.024 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.463506e-01 | 0.024 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.463506e-01 | 0.024 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.463506e-01 | 0.024 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 9.469788e-01 | 0.024 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 9.502920e-01 | 0.022 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 9.502920e-01 | 0.022 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 9.504629e-01 | 0.022 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 9.504629e-01 | 0.022 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 9.504629e-01 | 0.022 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 9.504629e-01 | 0.022 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 9.504629e-01 | 0.022 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 9.504629e-01 | 0.022 | 0 | 0 |
| Fructose catabolism | R-HSA-70350 | 9.504629e-01 | 0.022 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 9.504629e-01 | 0.022 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.505579e-01 | 0.022 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.505579e-01 | 0.022 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.505990e-01 | 0.022 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.505990e-01 | 0.022 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 9.505990e-01 | 0.022 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 9.507021e-01 | 0.022 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 9.513931e-01 | 0.022 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 9.518152e-01 | 0.021 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 9.526160e-01 | 0.021 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.526160e-01 | 0.021 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 9.526160e-01 | 0.021 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.530097e-01 | 0.021 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 9.549211e-01 | 0.020 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 9.557663e-01 | 0.020 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.557663e-01 | 0.020 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 9.566529e-01 | 0.019 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 9.566529e-01 | 0.019 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 9.572473e-01 | 0.019 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 9.573779e-01 | 0.019 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.573779e-01 | 0.019 | 0 | 0 |
| Biosynthesis of maresin-like SPMs | R-HSA-9027307 | 9.573779e-01 | 0.019 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 9.573779e-01 | 0.019 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | R-HSA-400511 | 9.573779e-01 | 0.019 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 9.573779e-01 | 0.019 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 9.573779e-01 | 0.019 | 0 | 0 |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | R-HSA-193807 | 9.581780e-01 | 0.019 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.596002e-01 | 0.018 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.596002e-01 | 0.018 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.596002e-01 | 0.018 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 9.602218e-01 | 0.018 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.604238e-01 | 0.018 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 9.604238e-01 | 0.018 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.608529e-01 | 0.017 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 9.608529e-01 | 0.017 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.624164e-01 | 0.017 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.627130e-01 | 0.017 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.630475e-01 | 0.016 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.631110e-01 | 0.016 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 9.633280e-01 | 0.016 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 9.633280e-01 | 0.016 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 9.633280e-01 | 0.016 | 0 | 0 |
| Biosynthesis of aspirin-triggered D-series resolvins | R-HSA-9020265 | 9.633280e-01 | 0.016 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 9.633280e-01 | 0.016 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 9.633280e-01 | 0.016 | 0 | 0 |
| Sulfide oxidation to sulfate | R-HSA-1614517 | 9.633280e-01 | 0.016 | 0 | 0 |
| Catecholamine biosynthesis | R-HSA-209905 | 9.633280e-01 | 0.016 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 9.633280e-01 | 0.016 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 9.633280e-01 | 0.016 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 9.646175e-01 | 0.016 | 0 | 0 |
| Regulation of pyruvate dehydrogenase (PDH) complex | R-HSA-204174 | 9.674821e-01 | 0.014 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.674821e-01 | 0.014 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 9.674821e-01 | 0.014 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.683897e-01 | 0.014 | 0 | 0 |
| Activated point mutants of FGFR2 | R-HSA-2033519 | 9.684478e-01 | 0.014 | 0 | 0 |
| Biosynthesis of Lipoxins (LX) | R-HSA-2142700 | 9.684478e-01 | 0.014 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 9.684478e-01 | 0.014 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 9.684478e-01 | 0.014 | 0 | 0 |
| Biosynthesis of DHA-derived sulfido conjugates | R-HSA-9026395 | 9.684478e-01 | 0.014 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.684478e-01 | 0.014 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.686533e-01 | 0.014 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 9.711482e-01 | 0.013 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 9.713521e-01 | 0.013 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.713521e-01 | 0.013 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 9.717793e-01 | 0.012 | 0 | 0 |
| Pyrimidine biosynthesis | R-HSA-500753 | 9.728530e-01 | 0.012 | 0 | 0 |
| Synthesis of 5-eicosatetraenoic acids | R-HSA-2142688 | 9.728530e-01 | 0.012 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 9.728530e-01 | 0.012 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 9.728530e-01 | 0.012 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 9.730659e-01 | 0.012 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.747096e-01 | 0.011 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.747096e-01 | 0.011 | 0 | 0 |
| Synthesis of glycosylphosphatidylinositol (GPI) | R-HSA-162710 | 9.747756e-01 | 0.011 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 9.748224e-01 | 0.011 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.748224e-01 | 0.011 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 9.748224e-01 | 0.011 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 9.766434e-01 | 0.010 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 9.766434e-01 | 0.010 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 9.766434e-01 | 0.010 | 0 | 0 |
| Wax and plasmalogen biosynthesis | R-HSA-8848584 | 9.766434e-01 | 0.010 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 9.766434e-01 | 0.010 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.767392e-01 | 0.010 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.767392e-01 | 0.010 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.778018e-01 | 0.010 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.778018e-01 | 0.010 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 9.781101e-01 | 0.010 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.790959e-01 | 0.009 | 0 | 0 |
| FGFR2 ligand binding and activation | R-HSA-190241 | 9.799048e-01 | 0.009 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 9.799048e-01 | 0.009 | 0 | 0 |
| Biosynthesis of E-series 18(S)-resolvins | R-HSA-9018896 | 9.799048e-01 | 0.009 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 9.799048e-01 | 0.009 | 0 | 0 |
| Phenylalanine metabolism | R-HSA-8964208 | 9.799048e-01 | 0.009 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 9.799048e-01 | 0.009 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.799048e-01 | 0.009 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 9.799048e-01 | 0.009 | 0 | 0 |
| Defective B3GALTL causes PpS | R-HSA-5083635 | 9.804750e-01 | 0.009 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 9.804750e-01 | 0.009 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.812011e-01 | 0.008 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.821887e-01 | 0.008 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 9.827109e-01 | 0.008 | 0 | 0 |
| Eicosanoids | R-HSA-211979 | 9.827109e-01 | 0.008 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 9.827109e-01 | 0.008 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 9.827109e-01 | 0.008 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.828346e-01 | 0.008 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 9.828346e-01 | 0.008 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 9.829906e-01 | 0.007 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.841485e-01 | 0.007 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.841485e-01 | 0.007 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.848450e-01 | 0.007 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.849161e-01 | 0.007 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.849161e-01 | 0.007 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 9.849161e-01 | 0.007 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.849161e-01 | 0.007 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.850526e-01 | 0.007 | 0 | 0 |
| Biosynthesis of D-series resolvins | R-HSA-9018676 | 9.851253e-01 | 0.007 | 0 | 0 |
| WNT ligand biogenesis and trafficking | R-HSA-3238698 | 9.851253e-01 | 0.007 | 0 | 0 |
| Fructose metabolism | R-HSA-5652084 | 9.851253e-01 | 0.007 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 9.851253e-01 | 0.007 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 9.851253e-01 | 0.007 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.851889e-01 | 0.006 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 9.854824e-01 | 0.006 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.859008e-01 | 0.006 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 9.859008e-01 | 0.006 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.859008e-01 | 0.006 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.864050e-01 | 0.006 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.867512e-01 | 0.006 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 9.867512e-01 | 0.006 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.867512e-01 | 0.006 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.872027e-01 | 0.006 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 9.872027e-01 | 0.006 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 9.872027e-01 | 0.006 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.872880e-01 | 0.006 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.878049e-01 | 0.005 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.883681e-01 | 0.005 | 0 | 0 |
| CYP2E1 reactions | R-HSA-211999 | 9.889900e-01 | 0.005 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.889900e-01 | 0.005 | 0 | 0 |
| Assembly of active LPL and LIPC lipase complexes | R-HSA-8963889 | 9.889900e-01 | 0.005 | 0 | 0 |
| Synthesis of dolichyl-phosphate | R-HSA-446199 | 9.889900e-01 | 0.005 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.889900e-01 | 0.005 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.892116e-01 | 0.005 | 0 | 0 |
| O-glycosylation of TSR domain-containing proteins | R-HSA-5173214 | 9.897919e-01 | 0.004 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 9.897919e-01 | 0.004 | 0 | 0 |
| SLC-mediated transport of organic cations | R-HSA-549127 | 9.897919e-01 | 0.004 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.897919e-01 | 0.004 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.897919e-01 | 0.004 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.898495e-01 | 0.004 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.902192e-01 | 0.004 | 0 | 0 |
| Alpha-oxidation of phytanate | R-HSA-389599 | 9.905278e-01 | 0.004 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.905278e-01 | 0.004 | 0 | 0 |
| Defects in cobalamin (B12) metabolism | R-HSA-3296469 | 9.905278e-01 | 0.004 | 0 | 0 |
| Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives | R-HSA-9027604 | 9.905278e-01 | 0.004 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.905278e-01 | 0.004 | 0 | 0 |
| Fertilization | R-HSA-1187000 | 9.905278e-01 | 0.004 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.905278e-01 | 0.004 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.910449e-01 | 0.004 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.912455e-01 | 0.004 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.912455e-01 | 0.004 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.917471e-01 | 0.004 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.918509e-01 | 0.004 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.918509e-01 | 0.004 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.918509e-01 | 0.004 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.918509e-01 | 0.004 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 9.918509e-01 | 0.004 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 9.918509e-01 | 0.004 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 9.921472e-01 | 0.003 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.921472e-01 | 0.003 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 9.921681e-01 | 0.003 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.925710e-01 | 0.003 | 0 | 0 |
| Cobalamin (Cbl) metabolism | R-HSA-9759218 | 9.929892e-01 | 0.003 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 9.929892e-01 | 0.003 | 0 | 0 |
| Biosynthesis of DPAn-3 SPMs | R-HSA-9025094 | 9.929892e-01 | 0.003 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.929892e-01 | 0.003 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.929892e-01 | 0.003 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 9.929892e-01 | 0.003 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 9.929892e-01 | 0.003 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.930948e-01 | 0.003 | 0 | 0 |
| Maturation of TCA enzymes and regulation of TCA cycle | R-HSA-9854311 | 9.931163e-01 | 0.003 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.939680e-01 | 0.003 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.939680e-01 | 0.003 | 0 | 0 |
| Prednisone ADME | R-HSA-9757110 | 9.939686e-01 | 0.003 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.939686e-01 | 0.003 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.944972e-01 | 0.002 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.945778e-01 | 0.002 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.945975e-01 | 0.002 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.947162e-01 | 0.002 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.947646e-01 | 0.002 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.948112e-01 | 0.002 | 0 | 0 |
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 9.948112e-01 | 0.002 | 0 | 0 |
| Biosynthesis of EPA-derived SPMs | R-HSA-9018679 | 9.948112e-01 | 0.002 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.949609e-01 | 0.002 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.953730e-01 | 0.002 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.953730e-01 | 0.002 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.953730e-01 | 0.002 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.955451e-01 | 0.002 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.957497e-01 | 0.002 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 9.959496e-01 | 0.002 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.960260e-01 | 0.002 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.960880e-01 | 0.002 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.960880e-01 | 0.002 | 0 | 0 |
| Biosynthesis of DPA-derived SPMs | R-HSA-9018683 | 9.961599e-01 | 0.002 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 9.961599e-01 | 0.002 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.964566e-01 | 0.002 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.968989e-01 | 0.001 | 0 | 0 |
| Diseases associated with glycosylation precursor biosynthesis | R-HSA-5609975 | 9.971581e-01 | 0.001 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.971864e-01 | 0.001 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.971864e-01 | 0.001 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 9.972877e-01 | 0.001 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.974010e-01 | 0.001 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.974010e-01 | 0.001 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.974858e-01 | 0.001 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.974944e-01 | 0.001 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.975552e-01 | 0.001 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.975862e-01 | 0.001 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.978100e-01 | 0.001 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 9.978969e-01 | 0.001 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 9.978969e-01 | 0.001 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 9.979270e-01 | 0.001 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.979722e-01 | 0.001 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.979722e-01 | 0.001 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.981156e-01 | 0.001 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.981884e-01 | 0.001 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.981884e-01 | 0.001 | 0 | 0 |
| Metabolism of ingested SeMet, Sec, MeSec into H2Se | R-HSA-2408508 | 9.981908e-01 | 0.001 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.981908e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | R-HSA-193775 | 9.981908e-01 | 0.001 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.982098e-01 | 0.001 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.982284e-01 | 0.001 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.982347e-01 | 0.001 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.984173e-01 | 0.001 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.984173e-01 | 0.001 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.984304e-01 | 0.001 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.984437e-01 | 0.001 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.984567e-01 | 0.001 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.985492e-01 | 0.001 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.986175e-01 | 0.001 | 0 | 0 |
| Phenylalanine and tyrosine metabolism | R-HSA-8963691 | 9.986612e-01 | 0.001 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.986612e-01 | 0.001 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.986612e-01 | 0.001 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.987238e-01 | 0.001 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.988484e-01 | 0.001 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 9.988484e-01 | 0.001 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.988532e-01 | 0.000 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.988990e-01 | 0.000 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.988990e-01 | 0.000 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.990094e-01 | 0.000 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.990094e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.990448e-01 | 0.000 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.990448e-01 | 0.000 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.990448e-01 | 0.000 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.991479e-01 | 0.000 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.991479e-01 | 0.000 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.991493e-01 | 0.000 | 0 | 0 |
| Heme biosynthesis | R-HSA-189451 | 9.993695e-01 | 0.000 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.993891e-01 | 0.000 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.993891e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.994252e-01 | 0.000 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.994252e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.995234e-01 | 0.000 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.995335e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.995354e-01 | 0.000 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.995950e-01 | 0.000 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.995987e-01 | 0.000 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.995987e-01 | 0.000 | 0 | 0 |
| Methylation | R-HSA-156581 | 9.995987e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.996151e-01 | 0.000 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 9.996362e-01 | 0.000 | 0 | 0 |
| Endogenous sterols | R-HSA-211976 | 9.996470e-01 | 0.000 | 0 | 0 |
| Degradation of cysteine and homocysteine | R-HSA-1614558 | 9.996548e-01 | 0.000 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.996557e-01 | 0.000 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.996897e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.997106e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.997401e-01 | 0.000 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.997446e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.997622e-01 | 0.000 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.997665e-01 | 0.000 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.997804e-01 | 0.000 | 0 | 0 |
| Biosynthesis of DHA-derived SPMs | R-HSA-9018677 | 9.998416e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.998416e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.998658e-01 | 0.000 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.998764e-01 | 0.000 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.999076e-01 | 0.000 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.999115e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.999150e-01 | 0.000 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.999330e-01 | 0.000 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.999338e-01 | 0.000 | 0 | 0 |
| Digestion | R-HSA-8935690 | 9.999342e-01 | 0.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.999366e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999374e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999445e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.999544e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.999544e-01 | 0.000 | 0 | 0 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 9.999711e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.999726e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999742e-01 | 0.000 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.999744e-01 | 0.000 | 0 | 0 |
| Digestion and absorption | R-HSA-8963743 | 9.999771e-01 | 0.000 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.999794e-01 | 0.000 | 0 | 0 |
| Xenobiotics | R-HSA-211981 | 9.999803e-01 | 0.000 | 0 | 0 |
| Latent infection - Other responses of Mtb to phagocytosis | R-HSA-1222499 | 9.999831e-01 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 9.999850e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.999852e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.999857e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.999887e-01 | 0.000 | 0 | 0 |
| Sulfur amino acid metabolism | R-HSA-1614635 | 9.999906e-01 | 0.000 | 0 | 0 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | R-HSA-420499 | 9.999929e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.999933e-01 | 0.000 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.999933e-01 | 0.000 | 0 | 0 |
| Purine catabolism | R-HSA-74259 | 9.999941e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999942e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.999947e-01 | 0.000 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.999949e-01 | 0.000 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.999955e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999963e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999971e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.999976e-01 | 0.000 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.999977e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999978e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999979e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999982e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999997e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999998e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999998e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999998e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999999e-01 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.999999e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999999e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 1.000000e+00 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of specialized proresolving mediators (SPMs) | R-HSA-9018678 | 1.000000e+00 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 1.000000e+00 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 1.000000e+00 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 1.000000e+00 | 0.000 | 0 | 0 |
| Nucleotide catabolism | R-HSA-8956319 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 1 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cellular response to heat stress | R-HSA-3371556 | 2.120526e-14 | 13.674 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 8.217871e-13 | 12.085 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 1.547207e-12 | 11.810 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 1.362654e-11 | 10.866 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 2.200151e-11 | 10.658 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 9.183265e-11 | 10.037 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 8.955026e-11 | 10.048 | 0 | 0 |
| M Phase | R-HSA-68886 | 1.539029e-10 | 9.813 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 3.796456e-10 | 9.421 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 5.410155e-10 | 9.267 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.123928e-09 | 8.949 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 2.139077e-09 | 8.670 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 5.768165e-09 | 8.239 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 2.804881e-08 | 7.552 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.776104e-08 | 7.321 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 4.977113e-08 | 7.303 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 8.041143e-08 | 7.095 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 8.752668e-08 | 7.058 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.298221e-07 | 6.887 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 1.397177e-07 | 6.855 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 1.744298e-07 | 6.758 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.733059e-07 | 6.761 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 1.752372e-07 | 6.756 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 1.932597e-07 | 6.714 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 2.810550e-07 | 6.551 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 3.156504e-07 | 6.501 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 3.156504e-07 | 6.501 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 5.328370e-07 | 6.273 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 7.361149e-07 | 6.133 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 8.002574e-07 | 6.097 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 8.549116e-07 | 6.068 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 9.116114e-07 | 6.040 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 1.041272e-06 | 5.982 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 1.120163e-06 | 5.951 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 1.155742e-06 | 5.937 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.446876e-06 | 5.840 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.649960e-06 | 5.783 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 2.003525e-06 | 5.698 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 3.093120e-06 | 5.510 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 3.187389e-06 | 5.497 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 3.424584e-06 | 5.465 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 3.462602e-06 | 5.461 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 3.895306e-06 | 5.409 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 3.992095e-06 | 5.399 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 4.124481e-06 | 5.385 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 4.698454e-06 | 5.328 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 5.341427e-06 | 5.272 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 5.928950e-06 | 5.227 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 6.065805e-06 | 5.217 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 8.960963e-06 | 5.048 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 8.743372e-06 | 5.058 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 9.150671e-06 | 5.039 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 9.284332e-06 | 5.032 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 8.703440e-06 | 5.060 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 9.612664e-06 | 5.017 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 1.022842e-05 | 4.990 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 1.168291e-05 | 4.932 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 1.269623e-05 | 4.896 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 1.290206e-05 | 4.889 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 1.335005e-05 | 4.875 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.363699e-05 | 4.865 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 1.386934e-05 | 4.858 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.437192e-05 | 4.842 | 0 | 0 |
| Kinesins | R-HSA-983189 | 1.386934e-05 | 4.858 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 1.731006e-05 | 4.762 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 1.838910e-05 | 4.735 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 1.937035e-05 | 4.713 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 1.870196e-05 | 4.728 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.941057e-05 | 4.712 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.066824e-05 | 4.685 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 2.475231e-05 | 4.606 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 2.475231e-05 | 4.606 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 2.587961e-05 | 4.587 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 2.610403e-05 | 4.583 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 2.610403e-05 | 4.583 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 2.900803e-05 | 4.537 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 3.135152e-05 | 4.504 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 3.135152e-05 | 4.504 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 3.356508e-05 | 4.474 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 3.915773e-05 | 4.407 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 3.804160e-05 | 4.420 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 3.916637e-05 | 4.407 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 4.291087e-05 | 4.367 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 4.332845e-05 | 4.363 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 4.639063e-05 | 4.334 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 5.085268e-05 | 4.294 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 5.503490e-05 | 4.259 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 5.890312e-05 | 4.230 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 5.921473e-05 | 4.228 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 6.134247e-05 | 4.212 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 6.750250e-05 | 4.171 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 6.564527e-05 | 4.183 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 8.818083e-05 | 4.055 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 8.853092e-05 | 4.053 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 9.003886e-05 | 4.046 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 8.943629e-05 | 4.048 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 9.251095e-05 | 4.034 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 9.902449e-05 | 4.004 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 1.050069e-04 | 3.979 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 1.102037e-04 | 3.958 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 1.198472e-04 | 3.921 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 1.184449e-04 | 3.926 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 1.212222e-04 | 3.916 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 1.212222e-04 | 3.916 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 1.338922e-04 | 3.873 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 1.385061e-04 | 3.859 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 1.385061e-04 | 3.859 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.386632e-04 | 3.858 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 1.752506e-04 | 3.756 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 1.705338e-04 | 3.768 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 1.832112e-04 | 3.737 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 1.931895e-04 | 3.714 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 2.115006e-04 | 3.675 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 2.154159e-04 | 3.667 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 2.154159e-04 | 3.667 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 2.225511e-04 | 3.653 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 2.225511e-04 | 3.653 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 2.435901e-04 | 3.613 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 2.631422e-04 | 3.580 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 2.699854e-04 | 3.569 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 2.941842e-04 | 3.531 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 3.007582e-04 | 3.522 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 3.105219e-04 | 3.508 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 3.369415e-04 | 3.472 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 3.369415e-04 | 3.472 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 3.443905e-04 | 3.463 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 3.617512e-04 | 3.442 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 3.648892e-04 | 3.438 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 3.648892e-04 | 3.438 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 3.760344e-04 | 3.425 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 4.356136e-04 | 3.361 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 4.475901e-04 | 3.349 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 4.482109e-04 | 3.349 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 4.482109e-04 | 3.349 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 4.809308e-04 | 3.318 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 5.046153e-04 | 3.297 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 5.635315e-04 | 3.249 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 5.732041e-04 | 3.242 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 5.987978e-04 | 3.223 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 5.939364e-04 | 3.226 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 6.205207e-04 | 3.207 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 5.732041e-04 | 3.242 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 5.826927e-04 | 3.235 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 5.826927e-04 | 3.235 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 6.328781e-04 | 3.199 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 6.457111e-04 | 3.190 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 6.457393e-04 | 3.190 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 6.613062e-04 | 3.180 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 6.759592e-04 | 3.170 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 6.828909e-04 | 3.166 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 7.160744e-04 | 3.145 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 7.388829e-04 | 3.131 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 7.466907e-04 | 3.127 | 0 | 0 |
| Depurination | R-HSA-73927 | 7.518129e-04 | 3.124 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 8.498920e-04 | 3.071 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 8.256449e-04 | 3.083 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 8.256449e-04 | 3.083 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 7.683971e-04 | 3.114 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 8.038708e-04 | 3.095 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 9.833669e-04 | 3.007 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.001910e-03 | 2.999 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 1.023934e-03 | 2.990 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 1.025109e-03 | 2.989 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 1.040567e-03 | 2.983 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.040567e-03 | 2.983 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.040567e-03 | 2.983 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 1.092976e-03 | 2.961 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 1.092976e-03 | 2.961 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 1.110549e-03 | 2.954 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 1.217184e-03 | 2.915 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 1.294551e-03 | 2.888 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 1.335482e-03 | 2.874 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 1.410447e-03 | 2.851 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 1.596624e-03 | 2.797 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 1.531444e-03 | 2.815 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 1.581622e-03 | 2.801 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 1.631599e-03 | 2.787 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 1.631599e-03 | 2.787 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.691705e-03 | 2.772 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.691705e-03 | 2.772 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 1.721394e-03 | 2.764 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 1.806127e-03 | 2.743 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 1.833092e-03 | 2.737 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 2.017798e-03 | 2.695 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 2.048159e-03 | 2.689 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 2.068605e-03 | 2.684 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 2.252534e-03 | 2.647 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 2.289308e-03 | 2.640 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 2.445531e-03 | 2.612 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 2.775656e-03 | 2.557 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 2.722699e-03 | 2.565 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 2.771478e-03 | 2.557 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 2.639020e-03 | 2.579 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 2.820670e-03 | 2.550 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 2.639020e-03 | 2.579 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 2.844575e-03 | 2.546 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 2.881746e-03 | 2.540 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 2.948934e-03 | 2.530 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 3.046047e-03 | 2.516 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 3.065287e-03 | 2.514 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 3.065287e-03 | 2.514 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 3.077031e-03 | 2.512 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 3.174759e-03 | 2.498 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 3.174759e-03 | 2.498 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 3.247684e-03 | 2.488 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 3.309531e-03 | 2.480 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 3.338381e-03 | 2.476 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 3.338381e-03 | 2.476 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 3.338381e-03 | 2.476 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 3.338381e-03 | 2.476 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 3.338381e-03 | 2.476 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 3.537706e-03 | 2.451 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 3.537706e-03 | 2.451 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 3.712952e-03 | 2.430 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 3.712952e-03 | 2.430 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 3.747017e-03 | 2.426 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 3.747017e-03 | 2.426 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 3.749948e-03 | 2.426 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 4.490399e-03 | 2.348 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 4.506215e-03 | 2.346 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 4.506215e-03 | 2.346 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 4.426696e-03 | 2.354 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 4.376853e-03 | 2.359 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 4.374181e-03 | 2.359 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 4.529295e-03 | 2.344 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 4.121074e-03 | 2.385 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 3.953872e-03 | 2.403 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 4.646722e-03 | 2.333 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 4.852424e-03 | 2.314 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 4.964704e-03 | 2.304 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 5.025392e-03 | 2.299 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 5.424995e-03 | 2.266 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 5.425276e-03 | 2.266 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 5.425276e-03 | 2.266 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 5.425276e-03 | 2.266 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 5.425276e-03 | 2.266 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 5.425276e-03 | 2.266 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 5.427183e-03 | 2.265 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 5.427183e-03 | 2.265 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 5.506888e-03 | 2.259 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 5.639070e-03 | 2.249 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 5.663023e-03 | 2.247 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 5.669499e-03 | 2.246 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 5.786496e-03 | 2.238 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 5.892828e-03 | 2.230 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 5.892828e-03 | 2.230 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 5.892828e-03 | 2.230 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 5.967490e-03 | 2.224 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 6.045226e-03 | 2.219 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 6.083847e-03 | 2.216 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 6.083847e-03 | 2.216 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 6.483009e-03 | 2.188 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 6.549666e-03 | 2.184 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 6.549666e-03 | 2.184 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 7.014323e-03 | 2.154 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 7.014323e-03 | 2.154 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 7.839573e-03 | 2.106 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 8.144871e-03 | 2.089 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 8.144871e-03 | 2.089 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 7.152142e-03 | 2.146 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 7.655962e-03 | 2.116 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 7.011791e-03 | 2.154 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 7.444439e-03 | 2.128 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 8.215789e-03 | 2.085 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 9.315806e-03 | 2.031 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 9.315806e-03 | 2.031 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 9.490755e-03 | 2.023 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 9.490755e-03 | 2.023 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 9.636596e-03 | 2.016 | 0 | 0 |
| Protein folding | R-HSA-391251 | 9.636596e-03 | 2.016 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 9.893270e-03 | 2.005 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 9.897501e-03 | 2.004 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 9.926536e-03 | 2.003 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 9.926536e-03 | 2.003 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 1.038298e-02 | 1.984 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.066217e-02 | 1.972 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.081660e-02 | 1.966 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 1.104937e-02 | 1.957 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 1.107829e-02 | 1.956 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.107829e-02 | 1.956 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 1.128956e-02 | 1.947 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 1.143271e-02 | 1.942 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 1.205002e-02 | 1.919 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 1.245166e-02 | 1.905 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 1.267783e-02 | 1.897 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 1.283287e-02 | 1.892 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 1.287556e-02 | 1.890 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 1.317600e-02 | 1.880 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 1.317600e-02 | 1.880 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 1.317600e-02 | 1.880 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 1.350281e-02 | 1.870 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.379200e-02 | 1.860 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 1.411644e-02 | 1.850 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.521846e-02 | 1.818 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.541791e-02 | 1.812 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 1.568201e-02 | 1.805 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 1.592454e-02 | 1.798 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 1.646486e-02 | 1.783 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 1.646486e-02 | 1.783 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 1.646486e-02 | 1.783 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 1.646486e-02 | 1.783 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 1.659913e-02 | 1.780 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 1.686689e-02 | 1.773 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 1.745130e-02 | 1.758 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 1.748468e-02 | 1.757 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 1.756333e-02 | 1.755 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 1.756333e-02 | 1.755 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 1.802959e-02 | 1.744 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 1.832521e-02 | 1.737 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 1.864966e-02 | 1.729 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 1.886226e-02 | 1.724 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 1.937914e-02 | 1.713 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 2.184490e-02 | 1.661 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 2.371213e-02 | 1.625 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 2.004840e-02 | 1.698 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 2.422399e-02 | 1.616 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 2.422399e-02 | 1.616 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 1.992754e-02 | 1.701 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 2.001806e-02 | 1.699 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 2.217298e-02 | 1.654 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.992754e-02 | 1.701 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 2.204514e-02 | 1.657 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 2.422399e-02 | 1.616 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 2.043574e-02 | 1.690 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 2.457898e-02 | 1.609 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 2.474047e-02 | 1.607 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 2.550353e-02 | 1.593 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 2.550353e-02 | 1.593 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 2.590776e-02 | 1.587 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 2.671178e-02 | 1.573 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 2.689268e-02 | 1.570 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 2.698532e-02 | 1.569 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 2.710410e-02 | 1.567 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 2.737123e-02 | 1.563 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 2.806152e-02 | 1.552 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.870084e-02 | 1.542 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.870084e-02 | 1.542 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.870084e-02 | 1.542 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.870084e-02 | 1.542 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 2.933781e-02 | 1.533 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 2.952938e-02 | 1.530 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 3.016964e-02 | 1.520 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 3.049632e-02 | 1.516 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 3.054549e-02 | 1.515 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 3.138626e-02 | 1.503 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 3.138626e-02 | 1.503 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 3.169892e-02 | 1.499 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 3.221925e-02 | 1.492 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 3.265945e-02 | 1.486 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 3.306818e-02 | 1.481 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 3.308074e-02 | 1.480 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 3.367995e-02 | 1.473 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 3.367995e-02 | 1.473 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 3.452283e-02 | 1.462 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 3.496919e-02 | 1.456 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 3.536288e-02 | 1.451 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 3.669605e-02 | 1.435 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 3.698645e-02 | 1.432 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 3.785540e-02 | 1.422 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 4.098758e-02 | 1.387 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 4.127266e-02 | 1.384 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 4.146815e-02 | 1.382 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 4.257410e-02 | 1.371 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.355046e-02 | 1.361 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 4.361393e-02 | 1.360 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 4.361393e-02 | 1.360 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 4.405940e-02 | 1.356 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 4.423469e-02 | 1.354 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 4.551480e-02 | 1.342 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 4.587584e-02 | 1.338 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 4.627534e-02 | 1.335 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 4.627534e-02 | 1.335 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 4.754427e-02 | 1.323 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 4.822224e-02 | 1.317 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 4.822224e-02 | 1.317 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.829164e-02 | 1.316 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 4.875265e-02 | 1.312 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 4.903681e-02 | 1.309 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 4.975421e-02 | 1.303 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 4.975421e-02 | 1.303 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 5.003798e-02 | 1.301 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 5.003798e-02 | 1.301 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 5.017564e-02 | 1.300 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 5.285322e-02 | 1.277 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 5.285322e-02 | 1.277 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 5.285322e-02 | 1.277 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 5.274829e-02 | 1.278 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 5.274829e-02 | 1.278 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 6.828343e-02 | 1.166 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 5.730743e-02 | 1.242 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 5.484733e-02 | 1.261 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 5.285322e-02 | 1.277 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 6.223480e-02 | 1.206 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 5.730743e-02 | 1.242 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 5.274829e-02 | 1.278 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 6.206972e-02 | 1.207 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 6.095386e-02 | 1.215 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.310754e-02 | 1.275 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 5.201980e-02 | 1.284 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 5.669327e-02 | 1.246 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 5.941333e-02 | 1.226 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 6.372417e-02 | 1.196 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 5.805506e-02 | 1.236 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 6.307056e-02 | 1.200 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 5.571080e-02 | 1.254 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 6.984093e-02 | 1.156 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 7.054052e-02 | 1.152 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 7.054052e-02 | 1.152 | 0 | 0 |
| Signaling by FGFR1 amplification mutants | R-HSA-1839120 | 7.124135e-02 | 1.147 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 7.124135e-02 | 1.147 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 7.124135e-02 | 1.147 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 7.124135e-02 | 1.147 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 7.124135e-02 | 1.147 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 7.124135e-02 | 1.147 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 7.147004e-02 | 1.146 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 7.262662e-02 | 1.139 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 7.262662e-02 | 1.139 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 7.424549e-02 | 1.129 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 7.424549e-02 | 1.129 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 7.835460e-02 | 1.106 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 7.940212e-02 | 1.100 | 0 | 0 |
| Drug resistance of KIT mutants | R-HSA-9669937 | 8.338453e-02 | 1.079 | 0 | 0 |
| KIT mutants bind TKIs | R-HSA-9669921 | 8.338453e-02 | 1.079 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 8.338453e-02 | 1.079 | 0 | 0 |
| Sorafenib-resistant KIT mutants | R-HSA-9669936 | 8.338453e-02 | 1.079 | 0 | 0 |
| Sunitinib-resistant KIT mutants | R-HSA-9669934 | 8.338453e-02 | 1.079 | 0 | 0 |
| Imatinib-resistant KIT mutants | R-HSA-9669917 | 8.338453e-02 | 1.079 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 8.338453e-02 | 1.079 | 0 | 0 |
| Dasatinib-resistant KIT mutants | R-HSA-9669914 | 8.338453e-02 | 1.079 | 0 | 0 |
| Regorafenib-resistant KIT mutants | R-HSA-9669929 | 8.338453e-02 | 1.079 | 0 | 0 |
| Masitinib-resistant KIT mutants | R-HSA-9669924 | 8.338453e-02 | 1.079 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 8.338453e-02 | 1.079 | 0 | 0 |
| Nilotinib-resistant KIT mutants | R-HSA-9669926 | 8.338453e-02 | 1.079 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 8.338767e-02 | 1.079 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 8.634846e-02 | 1.064 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 8.634846e-02 | 1.064 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 8.634846e-02 | 1.064 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 8.780876e-02 | 1.056 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 8.865038e-02 | 1.052 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 8.865038e-02 | 1.052 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 8.865038e-02 | 1.052 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 8.865038e-02 | 1.052 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 8.957771e-02 | 1.048 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 8.962542e-02 | 1.048 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 8.962542e-02 | 1.048 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 8.962542e-02 | 1.048 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 9.275857e-02 | 1.033 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 9.553781e-02 | 1.020 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 9.703998e-02 | 1.013 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 9.703998e-02 | 1.013 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 9.703998e-02 | 1.013 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 9.703998e-02 | 1.013 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 9.703998e-02 | 1.013 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 9.703998e-02 | 1.013 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 9.703998e-02 | 1.013 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 9.934197e-02 | 1.003 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 1.004945e-01 | 0.998 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 1.005172e-01 | 0.998 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 1.005172e-01 | 0.998 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 1.005172e-01 | 0.998 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.032329e-01 | 0.986 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.058170e-01 | 0.975 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 1.060056e-01 | 0.975 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.598206e-01 | 0.796 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.598206e-01 | 0.796 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.598206e-01 | 0.796 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.598206e-01 | 0.796 | 0 | 0 |
| RPIA deficiency: failed conversion of RU5P to R5P | R-HSA-6791461 | 1.598206e-01 | 0.796 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.598206e-01 | 0.796 | 0 | 0 |
| RPIA deficiency: failed conversion of R5P to RU5P | R-HSA-5659996 | 1.598206e-01 | 0.796 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.598206e-01 | 0.796 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.249952e-01 | 0.903 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 1.545687e-01 | 0.811 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 1.545687e-01 | 0.811 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 1.245633e-01 | 0.905 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 1.245633e-01 | 0.905 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 1.245633e-01 | 0.905 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 1.245633e-01 | 0.905 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 1.441893e-01 | 0.841 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 1.278180e-01 | 0.893 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 1.278180e-01 | 0.893 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 1.431962e-01 | 0.844 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.201783e-01 | 0.920 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 1.514788e-01 | 0.820 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 1.108941e-01 | 0.955 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 1.114412e-01 | 0.953 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.201783e-01 | 0.920 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.431962e-01 | 0.844 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 1.118781e-01 | 0.951 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.201783e-01 | 0.920 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 1.441893e-01 | 0.841 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 1.442094e-01 | 0.841 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 1.367568e-01 | 0.864 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 1.249952e-01 | 0.903 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 1.249952e-01 | 0.903 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 1.108941e-01 | 0.955 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 1.441893e-01 | 0.841 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 1.076244e-01 | 0.968 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.367568e-01 | 0.864 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 1.545687e-01 | 0.811 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 1.367568e-01 | 0.864 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.415869e-01 | 0.849 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 1.545687e-01 | 0.811 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 1.179005e-01 | 0.928 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 1.499731e-01 | 0.824 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 1.249952e-01 | 0.903 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 1.070154e-01 | 0.971 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 1.431962e-01 | 0.844 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 1.190520e-01 | 0.924 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 1.557937e-01 | 0.807 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 1.356586e-01 | 0.868 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 1.190520e-01 | 0.924 | 0 | 0 |
| Translation | R-HSA-72766 | 1.529039e-01 | 0.816 | 0 | 0 |
| Formation of editosomes by ADAR proteins | R-HSA-77042 | 1.598206e-01 | 0.796 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 1.598206e-01 | 0.796 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 1.441893e-01 | 0.841 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 1.441893e-01 | 0.841 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 1.278180e-01 | 0.893 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 1.592583e-01 | 0.798 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 1.115445e-01 | 0.953 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 1.367568e-01 | 0.864 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 1.212190e-01 | 0.916 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 1.201783e-01 | 0.920 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 1.488008e-01 | 0.827 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 1.530897e-01 | 0.815 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 1.108941e-01 | 0.955 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 1.555012e-01 | 0.808 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 1.203400e-01 | 0.920 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 1.557306e-01 | 0.808 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 1.545687e-01 | 0.811 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 1.286462e-01 | 0.891 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.323659e-01 | 0.878 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 1.351201e-01 | 0.869 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 1.447151e-01 | 0.839 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 1.278180e-01 | 0.893 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 1.545687e-01 | 0.811 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 1.290061e-01 | 0.889 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 1.610503e-01 | 0.793 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 1.620110e-01 | 0.790 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 1.632437e-01 | 0.787 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 1.637025e-01 | 0.786 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 1.637025e-01 | 0.786 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 1.637025e-01 | 0.786 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 1.637025e-01 | 0.786 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 1.647482e-01 | 0.783 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 1.647482e-01 | 0.783 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 1.647482e-01 | 0.783 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 1.647482e-01 | 0.783 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 1.647482e-01 | 0.783 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 1.647482e-01 | 0.783 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 1.647482e-01 | 0.783 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 1.647482e-01 | 0.783 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 1.650455e-01 | 0.782 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 1.695336e-01 | 0.771 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 1.716280e-01 | 0.765 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 1.716280e-01 | 0.765 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.721619e-01 | 0.764 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 1.759079e-01 | 0.755 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 1.759438e-01 | 0.755 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.759438e-01 | 0.755 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 1.759438e-01 | 0.755 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 1.759695e-01 | 0.755 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 1.759695e-01 | 0.755 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 1.761930e-01 | 0.754 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 1.767825e-01 | 0.753 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 1.779107e-01 | 0.750 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 1.779107e-01 | 0.750 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 1.812696e-01 | 0.742 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 1.852966e-01 | 0.732 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 1.852966e-01 | 0.732 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 1.852966e-01 | 0.732 | 0 | 0 |
| Branched-chain ketoacid dehydrogenase kinase deficiency | R-HSA-9912481 | 1.852966e-01 | 0.732 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.852966e-01 | 0.732 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.861054e-01 | 0.730 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 1.861054e-01 | 0.730 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 1.887823e-01 | 0.724 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 1.904985e-01 | 0.720 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 1.904985e-01 | 0.720 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 1.925622e-01 | 0.715 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 1.925622e-01 | 0.715 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 1.931902e-01 | 0.714 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 1.931902e-01 | 0.714 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 1.931902e-01 | 0.714 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 1.931902e-01 | 0.714 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.988171e-01 | 0.702 | 0 | 0 |
| Signaling by juxtamembrane domain KIT mutants | R-HSA-9669935 | 2.298869e-01 | 0.638 | 0 | 0 |
| Signaling by extracellular domain mutants of KIT | R-HSA-9680187 | 2.298869e-01 | 0.638 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.298869e-01 | 0.638 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5619081 | 2.298869e-01 | 0.638 | 0 | 0 |
| Signaling by kinase domain mutants of KIT | R-HSA-9669933 | 2.298869e-01 | 0.638 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 2.298869e-01 | 0.638 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5660724 | 2.298869e-01 | 0.638 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 2.298869e-01 | 0.638 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 2.941139e-01 | 0.531 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 2.941139e-01 | 0.531 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 2.941139e-01 | 0.531 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.941139e-01 | 0.531 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.941139e-01 | 0.531 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.941139e-01 | 0.531 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 2.167811e-01 | 0.664 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 2.167811e-01 | 0.664 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 2.167811e-01 | 0.664 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 2.167811e-01 | 0.664 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 2.167811e-01 | 0.664 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 2.167811e-01 | 0.664 | 0 | 0 |
| Signaling by plasma membrane FGFR1 fusions | R-HSA-8853336 | 3.529879e-01 | 0.452 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 3.529879e-01 | 0.452 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.529879e-01 | 0.452 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 2.486828e-01 | 0.604 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 2.486828e-01 | 0.604 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 2.486828e-01 | 0.604 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 2.486828e-01 | 0.604 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 2.486828e-01 | 0.604 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 2.486828e-01 | 0.604 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 2.486828e-01 | 0.604 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 2.081290e-01 | 0.682 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 2.807134e-01 | 0.552 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 2.807134e-01 | 0.552 | 0 | 0 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 2.807134e-01 | 0.552 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 2.807134e-01 | 0.552 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 4.069547e-01 | 0.390 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 4.069547e-01 | 0.390 | 0 | 0 |
| Drug-mediated inhibition of CDK4/CDK6 activity | R-HSA-9754119 | 4.069547e-01 | 0.390 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 4.069547e-01 | 0.390 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 4.069547e-01 | 0.390 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 4.069547e-01 | 0.390 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 2.306916e-01 | 0.637 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 2.306916e-01 | 0.637 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 2.306916e-01 | 0.637 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 3.126297e-01 | 0.505 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 3.126297e-01 | 0.505 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 3.126297e-01 | 0.505 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 3.126297e-01 | 0.505 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 2.536715e-01 | 0.596 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 2.536715e-01 | 0.596 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 2.536715e-01 | 0.596 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 2.291124e-01 | 0.640 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 2.769531e-01 | 0.558 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 2.076199e-01 | 0.683 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 3.004284e-01 | 0.522 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 3.004284e-01 | 0.522 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 2.230460e-01 | 0.652 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 2.665186e-01 | 0.574 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 3.753402e-01 | 0.426 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 3.753402e-01 | 0.426 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 3.753402e-01 | 0.426 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 3.753402e-01 | 0.426 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 2.073076e-01 | 0.683 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 3.049164e-01 | 0.516 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 3.049164e-01 | 0.516 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 3.475639e-01 | 0.459 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 3.475639e-01 | 0.459 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 4.058270e-01 | 0.392 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 4.058270e-01 | 0.392 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 3.243405e-01 | 0.489 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 3.943637e-01 | 0.404 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 3.943637e-01 | 0.404 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 3.551061e-01 | 0.450 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 2.221004e-01 | 0.653 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 2.876624e-01 | 0.541 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 2.076199e-01 | 0.683 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 3.753402e-01 | 0.426 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 3.943637e-01 | 0.404 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 2.548492e-01 | 0.594 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.938379e-01 | 0.532 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 2.076199e-01 | 0.683 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 3.239964e-01 | 0.489 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 3.126297e-01 | 0.505 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 2.076199e-01 | 0.683 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 3.126297e-01 | 0.505 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 2.109343e-01 | 0.676 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 3.442283e-01 | 0.463 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 3.442283e-01 | 0.463 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 3.004284e-01 | 0.522 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 2.388020e-01 | 0.622 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.711489e-01 | 0.567 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 3.710456e-01 | 0.431 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 3.583586e-01 | 0.446 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 3.106107e-01 | 0.508 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 4.058270e-01 | 0.392 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 3.211797e-01 | 0.493 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 2.432506e-01 | 0.614 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 3.126297e-01 | 0.505 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 2.748271e-01 | 0.561 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 2.167811e-01 | 0.664 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 4.069547e-01 | 0.390 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 3.004284e-01 | 0.522 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 3.828661e-01 | 0.417 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 2.129551e-01 | 0.672 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 3.633661e-01 | 0.440 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 2.129551e-01 | 0.672 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 2.811187e-01 | 0.551 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 4.069547e-01 | 0.390 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 4.069547e-01 | 0.390 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 4.069547e-01 | 0.390 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 3.235226e-01 | 0.490 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 2.548492e-01 | 0.594 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 3.943637e-01 | 0.404 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 3.828661e-01 | 0.417 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 2.837134e-01 | 0.547 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 4.058270e-01 | 0.392 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 2.419508e-01 | 0.616 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 2.419508e-01 | 0.616 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.448234e-01 | 0.611 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 2.072496e-01 | 0.684 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 3.317321e-01 | 0.479 | 0 | 0 |
| TGFBR3 regulates FGF2 signaling | R-HSA-9839397 | 2.298869e-01 | 0.638 | 0 | 0 |
| Transport of connexins along the secretory pathway | R-HSA-190827 | 2.298869e-01 | 0.638 | 0 | 0 |
| mRNA Editing: A to I Conversion | R-HSA-75064 | 2.941139e-01 | 0.531 | 0 | 0 |
| C6 deamination of adenosine | R-HSA-75102 | 2.941139e-01 | 0.531 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 2.941139e-01 | 0.531 | 0 | 0 |
| Neurophilin interactions with VEGF and VEGFR | R-HSA-194306 | 2.941139e-01 | 0.531 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 2.941139e-01 | 0.531 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 3.126297e-01 | 0.505 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.769531e-01 | 0.558 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 3.753402e-01 | 0.426 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 3.239964e-01 | 0.489 | 0 | 0 |
| PKA activation | R-HSA-163615 | 3.239964e-01 | 0.489 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 3.239964e-01 | 0.489 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 3.710456e-01 | 0.431 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 3.438411e-01 | 0.464 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 2.774283e-01 | 0.557 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.721349e-01 | 0.429 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 4.022947e-01 | 0.395 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 3.621867e-01 | 0.441 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 3.891630e-01 | 0.410 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 3.891630e-01 | 0.410 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 2.841626e-01 | 0.546 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 3.673127e-01 | 0.435 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 2.142738e-01 | 0.669 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 2.152605e-01 | 0.667 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 2.089441e-01 | 0.680 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 2.710086e-01 | 0.567 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 4.129997e-01 | 0.384 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 3.721349e-01 | 0.429 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 2.807134e-01 | 0.552 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 3.126297e-01 | 0.505 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 2.867540e-01 | 0.542 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 2.701731e-01 | 0.568 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 2.367988e-01 | 0.626 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 2.167811e-01 | 0.664 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 2.807134e-01 | 0.552 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 4.069547e-01 | 0.390 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 2.548492e-01 | 0.594 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 4.058270e-01 | 0.392 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 2.419508e-01 | 0.616 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 2.167811e-01 | 0.664 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 2.081290e-01 | 0.682 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 2.655788e-01 | 0.576 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 3.166198e-01 | 0.499 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 2.437281e-01 | 0.613 | 0 | 0 |
| Oligomerization of connexins into connexons | R-HSA-190704 | 2.298869e-01 | 0.638 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 2.941139e-01 | 0.531 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 2.807134e-01 | 0.552 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 2.807134e-01 | 0.552 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 4.069547e-01 | 0.390 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.769531e-01 | 0.558 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 2.711489e-01 | 0.567 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 2.951528e-01 | 0.530 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 2.502518e-01 | 0.602 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 2.711489e-01 | 0.567 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 3.759460e-01 | 0.425 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 2.807134e-01 | 0.552 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 3.442283e-01 | 0.463 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 2.548492e-01 | 0.594 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 3.621867e-01 | 0.441 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 2.167811e-01 | 0.664 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.807134e-01 | 0.552 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 3.126297e-01 | 0.505 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 3.442283e-01 | 0.463 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 4.058270e-01 | 0.392 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 3.721349e-01 | 0.429 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 2.317448e-01 | 0.635 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 4.061589e-01 | 0.391 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 2.548492e-01 | 0.594 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 2.476613e-01 | 0.606 | 0 | 0 |
| ATF6B (ATF6-beta) activates chaperones | R-HSA-8874177 | 2.941139e-01 | 0.531 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 2.167811e-01 | 0.664 | 0 | 0 |
| FasL/ CD95L signaling | R-HSA-75157 | 3.529879e-01 | 0.452 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 2.807134e-01 | 0.552 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 3.442283e-01 | 0.463 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 3.943637e-01 | 0.404 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 3.006984e-01 | 0.522 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 2.998680e-01 | 0.523 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 2.613347e-01 | 0.583 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 3.442283e-01 | 0.463 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 3.345088e-01 | 0.476 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 3.851445e-01 | 0.414 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 2.856234e-01 | 0.544 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 3.853222e-01 | 0.414 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 2.081290e-01 | 0.682 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 3.126297e-01 | 0.505 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 4.174481e-01 | 0.379 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 4.174481e-01 | 0.379 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 4.230925e-01 | 0.374 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 4.230925e-01 | 0.374 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 4.230925e-01 | 0.374 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 4.230925e-01 | 0.374 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 4.233302e-01 | 0.373 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 4.233302e-01 | 0.373 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 4.355766e-01 | 0.361 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.355766e-01 | 0.361 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 4.355766e-01 | 0.361 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 4.355766e-01 | 0.361 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 4.355766e-01 | 0.361 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 4.355766e-01 | 0.361 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 4.385308e-01 | 0.358 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 4.399352e-01 | 0.357 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 4.402359e-01 | 0.356 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 4.402359e-01 | 0.356 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 4.402359e-01 | 0.356 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 4.402359e-01 | 0.356 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 4.402359e-01 | 0.356 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 4.402359e-01 | 0.356 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 4.407673e-01 | 0.356 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 4.407673e-01 | 0.356 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 4.453530e-01 | 0.351 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 4.453530e-01 | 0.351 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 4.536549e-01 | 0.343 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 4.564231e-01 | 0.341 | 0 | 0 |
| FGFR1c and Klotho ligand binding and activation | R-HSA-190374 | 4.564231e-01 | 0.341 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 4.564231e-01 | 0.341 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 4.564231e-01 | 0.341 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 4.564231e-01 | 0.341 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 4.564231e-01 | 0.341 | 0 | 0 |
| PTK6 Down-Regulation | R-HSA-8849472 | 4.564231e-01 | 0.341 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 4.564231e-01 | 0.341 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 4.564231e-01 | 0.341 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 4.564231e-01 | 0.341 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 4.564231e-01 | 0.341 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 4.564231e-01 | 0.341 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 4.564231e-01 | 0.341 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 4.566601e-01 | 0.340 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 4.566601e-01 | 0.340 | 0 | 0 |
| Immune System | R-HSA-168256 | 4.596439e-01 | 0.338 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 4.597337e-01 | 0.337 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 4.626714e-01 | 0.335 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 4.626714e-01 | 0.335 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 4.626714e-01 | 0.335 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 4.626714e-01 | 0.335 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 4.644480e-01 | 0.333 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 4.644999e-01 | 0.333 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 4.644999e-01 | 0.333 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 4.644999e-01 | 0.333 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 4.644999e-01 | 0.333 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 4.644999e-01 | 0.333 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 4.644999e-01 | 0.333 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 4.644999e-01 | 0.333 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 4.657063e-01 | 0.332 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 4.686828e-01 | 0.329 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 4.692132e-01 | 0.329 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 4.719237e-01 | 0.326 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 4.737281e-01 | 0.324 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 4.800777e-01 | 0.319 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.835960e-01 | 0.316 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 4.835960e-01 | 0.316 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 4.835960e-01 | 0.316 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 4.835960e-01 | 0.316 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 4.847055e-01 | 0.315 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 4.847055e-01 | 0.315 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 4.847055e-01 | 0.315 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 4.847055e-01 | 0.315 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 4.896571e-01 | 0.310 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 4.896571e-01 | 0.310 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 4.925279e-01 | 0.308 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 4.925279e-01 | 0.308 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 4.925279e-01 | 0.308 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 4.925279e-01 | 0.308 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 4.925279e-01 | 0.308 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 4.925279e-01 | 0.308 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 4.925279e-01 | 0.308 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 4.925279e-01 | 0.308 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 4.925279e-01 | 0.308 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 4.969552e-01 | 0.304 | 0 | 0 |
| Plus-strand DNA synthesis | R-HSA-164525 | 5.017679e-01 | 0.299 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 5.017679e-01 | 0.299 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 5.017679e-01 | 0.299 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 5.017679e-01 | 0.299 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 5.017679e-01 | 0.299 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 5.017679e-01 | 0.299 | 0 | 0 |
| Loss-of-function mutations in DBT cause MSUD2 | R-HSA-9865113 | 5.017679e-01 | 0.299 | 0 | 0 |
| Loss-of-function mutations in DLD cause MSUD3/DLDD | R-HSA-9907570 | 5.017679e-01 | 0.299 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 5.017679e-01 | 0.299 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 5.017679e-01 | 0.299 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 5.017679e-01 | 0.299 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.017679e-01 | 0.299 | 0 | 0 |
| VEGF binds to VEGFR leading to receptor dimerization | R-HSA-195399 | 5.017679e-01 | 0.299 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 5.017679e-01 | 0.299 | 0 | 0 |
| VEGF ligand-receptor interactions | R-HSA-194313 | 5.017679e-01 | 0.299 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 5.017679e-01 | 0.299 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 5.017679e-01 | 0.299 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 5.017679e-01 | 0.299 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 5.017679e-01 | 0.299 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 5.017679e-01 | 0.299 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 5.058835e-01 | 0.296 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 5.062956e-01 | 0.296 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 5.062956e-01 | 0.296 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 5.062956e-01 | 0.296 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 5.062956e-01 | 0.296 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 5.151508e-01 | 0.288 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 5.159189e-01 | 0.287 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 5.196087e-01 | 0.284 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 5.196087e-01 | 0.284 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 5.196087e-01 | 0.284 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 5.219008e-01 | 0.282 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 5.274050e-01 | 0.278 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 5.274050e-01 | 0.278 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 5.274050e-01 | 0.278 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 5.322988e-01 | 0.274 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 5.376905e-01 | 0.269 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 5.376905e-01 | 0.269 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 5.433325e-01 | 0.265 | 0 | 0 |
| Small interfering RNA (siRNA) biogenesis | R-HSA-426486 | 5.433325e-01 | 0.265 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 5.433325e-01 | 0.265 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 5.433325e-01 | 0.265 | 0 | 0 |
| Uncoating of the HIV Virion | R-HSA-162585 | 5.433325e-01 | 0.265 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 5.433325e-01 | 0.265 | 0 | 0 |
| H139Hfs13* PPM1K causes a mild variant of MSUD | R-HSA-9912529 | 5.433325e-01 | 0.265 | 0 | 0 |
| Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | R-HSA-9865125 | 5.433325e-01 | 0.265 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 5.433325e-01 | 0.265 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 5.433325e-01 | 0.265 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 5.433325e-01 | 0.265 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 5.457053e-01 | 0.263 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 5.457053e-01 | 0.263 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.457053e-01 | 0.263 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 5.457053e-01 | 0.263 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 5.457053e-01 | 0.263 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 5.457053e-01 | 0.263 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 5.480028e-01 | 0.261 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 5.480028e-01 | 0.261 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 5.505847e-01 | 0.259 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 5.532354e-01 | 0.257 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 5.577532e-01 | 0.254 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 5.680631e-01 | 0.246 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.680631e-01 | 0.246 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 5.685200e-01 | 0.245 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 5.685200e-01 | 0.245 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 5.707934e-01 | 0.244 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 5.707934e-01 | 0.244 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 5.707934e-01 | 0.244 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 5.723729e-01 | 0.242 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 5.814319e-01 | 0.236 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.814319e-01 | 0.236 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 5.814319e-01 | 0.236 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 5.814319e-01 | 0.236 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 5.814319e-01 | 0.236 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 5.814319e-01 | 0.236 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 5.814319e-01 | 0.236 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 5.814319e-01 | 0.236 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 5.814319e-01 | 0.236 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 5.814319e-01 | 0.236 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 5.814319e-01 | 0.236 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 5.814319e-01 | 0.236 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 5.814319e-01 | 0.236 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 5.814319e-01 | 0.236 | 0 | 0 |
| Maturation of replicase proteins | R-HSA-9694301 | 5.814319e-01 | 0.236 | 0 | 0 |
| S Phase | R-HSA-69242 | 5.834312e-01 | 0.234 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 5.835306e-01 | 0.234 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 5.846046e-01 | 0.233 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 5.846046e-01 | 0.233 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 5.847082e-01 | 0.233 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 5.869125e-01 | 0.231 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 5.875652e-01 | 0.231 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 5.875652e-01 | 0.231 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 5.875652e-01 | 0.231 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 5.948598e-01 | 0.226 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 5.948598e-01 | 0.226 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 5.948598e-01 | 0.226 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 5.963576e-01 | 0.224 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 5.967262e-01 | 0.224 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 5.973354e-01 | 0.224 | 1 | 1 |
| Potential therapeutics for SARS | R-HSA-9679191 | 6.011079e-01 | 0.221 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 6.064925e-01 | 0.217 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 6.064925e-01 | 0.217 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 6.064925e-01 | 0.217 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 6.098203e-01 | 0.215 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 6.115423e-01 | 0.214 | 0 | 0 |
| Reverse Transcription of HIV RNA | R-HSA-162589 | 6.163548e-01 | 0.210 | 0 | 0 |
| Minus-strand DNA synthesis | R-HSA-164516 | 6.163548e-01 | 0.210 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 6.163548e-01 | 0.210 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 6.163548e-01 | 0.210 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 6.163548e-01 | 0.210 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 6.163548e-01 | 0.210 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 6.163548e-01 | 0.210 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 6.163548e-01 | 0.210 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 6.163548e-01 | 0.210 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 6.163548e-01 | 0.210 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 6.163548e-01 | 0.210 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 6.163548e-01 | 0.210 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 6.163548e-01 | 0.210 | 0 | 0 |
| SLC-mediated bile acid transport | R-HSA-9958517 | 6.163548e-01 | 0.210 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 6.163548e-01 | 0.210 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 6.163548e-01 | 0.210 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 6.163548e-01 | 0.210 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 6.163548e-01 | 0.210 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 6.163548e-01 | 0.210 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 6.170814e-01 | 0.210 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 6.170814e-01 | 0.210 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 6.170814e-01 | 0.210 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 6.170814e-01 | 0.210 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 6.179001e-01 | 0.209 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 6.179001e-01 | 0.209 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 6.179001e-01 | 0.209 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 6.179001e-01 | 0.209 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 6.179001e-01 | 0.209 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 6.179001e-01 | 0.209 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 6.180205e-01 | 0.209 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 6.184444e-01 | 0.209 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 6.184444e-01 | 0.209 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 6.248328e-01 | 0.204 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 6.248328e-01 | 0.204 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 6.248328e-01 | 0.204 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 6.327110e-01 | 0.199 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 6.327110e-01 | 0.199 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 6.399182e-01 | 0.194 | 0 | 0 |
| Mitochondrial iron-sulfur cluster biogenesis | R-HSA-1362409 | 6.399182e-01 | 0.194 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 6.399182e-01 | 0.194 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 6.399182e-01 | 0.194 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 6.399182e-01 | 0.194 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 6.406056e-01 | 0.193 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 6.424340e-01 | 0.192 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 6.425775e-01 | 0.192 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 6.434982e-01 | 0.191 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 6.460346e-01 | 0.190 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 6.479231e-01 | 0.188 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 6.479231e-01 | 0.188 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 6.483658e-01 | 0.188 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 6.483658e-01 | 0.188 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 6.483658e-01 | 0.188 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 6.483658e-01 | 0.188 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 6.483658e-01 | 0.188 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 6.483658e-01 | 0.188 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.483658e-01 | 0.188 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 6.483658e-01 | 0.188 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 6.483658e-01 | 0.188 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.483658e-01 | 0.188 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 6.483658e-01 | 0.188 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 6.483658e-01 | 0.188 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 6.483658e-01 | 0.188 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 6.597214e-01 | 0.181 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 6.609241e-01 | 0.180 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 6.609241e-01 | 0.180 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 6.609241e-01 | 0.180 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 6.626513e-01 | 0.179 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 6.627113e-01 | 0.179 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 6.672433e-01 | 0.176 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 6.672433e-01 | 0.176 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 6.770710e-01 | 0.169 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 6.770710e-01 | 0.169 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 6.777075e-01 | 0.169 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 6.777075e-01 | 0.169 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 6.777075e-01 | 0.169 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 6.777075e-01 | 0.169 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 6.777075e-01 | 0.169 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 6.777075e-01 | 0.169 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.777075e-01 | 0.169 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 6.777075e-01 | 0.169 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 6.777075e-01 | 0.169 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 6.777075e-01 | 0.169 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 6.777075e-01 | 0.169 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 6.791078e-01 | 0.168 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 6.809335e-01 | 0.167 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 6.809335e-01 | 0.167 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 6.809335e-01 | 0.167 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 6.809335e-01 | 0.167 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 6.809335e-01 | 0.167 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.824165e-01 | 0.166 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 6.832418e-01 | 0.165 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 6.909995e-01 | 0.161 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 6.909995e-01 | 0.161 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 6.922014e-01 | 0.160 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 6.954515e-01 | 0.158 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.954515e-01 | 0.158 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 6.999663e-01 | 0.155 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 6.999663e-01 | 0.155 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 6.999663e-01 | 0.155 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 6.999663e-01 | 0.155 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 6.999663e-01 | 0.155 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 7.042936e-01 | 0.152 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 7.044954e-01 | 0.152 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 7.046025e-01 | 0.152 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 7.046025e-01 | 0.152 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 7.046025e-01 | 0.152 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 7.046025e-01 | 0.152 | 0 | 0 |
| SARS-CoV-2 modulates autophagy | R-HSA-9754560 | 7.046025e-01 | 0.152 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 7.046025e-01 | 0.152 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 7.046025e-01 | 0.152 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 7.047041e-01 | 0.152 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 7.075412e-01 | 0.150 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 7.075412e-01 | 0.150 | 0 | 0 |
| Disease | R-HSA-1643685 | 7.098829e-01 | 0.149 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 7.122465e-01 | 0.147 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 7.122465e-01 | 0.147 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 7.122465e-01 | 0.147 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 7.126216e-01 | 0.147 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 7.157777e-01 | 0.145 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 7.165152e-01 | 0.145 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 7.165152e-01 | 0.145 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 7.180462e-01 | 0.144 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 7.222872e-01 | 0.141 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 7.222872e-01 | 0.141 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 7.222872e-01 | 0.141 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 7.222872e-01 | 0.141 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 7.222872e-01 | 0.141 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 7.279870e-01 | 0.138 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 7.279870e-01 | 0.138 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 7.291760e-01 | 0.137 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.292546e-01 | 0.137 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 7.292546e-01 | 0.137 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.292546e-01 | 0.137 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.292546e-01 | 0.137 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 7.292546e-01 | 0.137 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 7.301916e-01 | 0.137 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 7.301916e-01 | 0.137 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 7.311811e-01 | 0.136 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 7.317657e-01 | 0.136 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 7.351996e-01 | 0.134 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 7.351996e-01 | 0.134 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 7.351996e-01 | 0.134 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 7.364466e-01 | 0.133 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 7.364466e-01 | 0.133 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 7.365042e-01 | 0.133 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 7.382226e-01 | 0.132 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 7.465722e-01 | 0.127 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 7.499151e-01 | 0.125 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 7.499151e-01 | 0.125 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 7.500284e-01 | 0.125 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 7.500284e-01 | 0.125 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 7.500284e-01 | 0.125 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 7.500284e-01 | 0.125 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.514553e-01 | 0.124 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 7.514553e-01 | 0.124 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.514553e-01 | 0.124 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 7.514553e-01 | 0.124 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 7.514553e-01 | 0.124 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 7.518507e-01 | 0.124 | 0 | 0 |
| Maple Syrup Urine Disease | R-HSA-9865114 | 7.518507e-01 | 0.124 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 7.518507e-01 | 0.124 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 7.518507e-01 | 0.124 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 7.518507e-01 | 0.124 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 7.518507e-01 | 0.124 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 7.518507e-01 | 0.124 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 7.518507e-01 | 0.124 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 7.518507e-01 | 0.124 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 7.518507e-01 | 0.124 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.518507e-01 | 0.124 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 7.518507e-01 | 0.124 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 7.518507e-01 | 0.124 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 7.518507e-01 | 0.124 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 7.518507e-01 | 0.124 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 7.518507e-01 | 0.124 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 7.518507e-01 | 0.124 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 7.518507e-01 | 0.124 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 7.518507e-01 | 0.124 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 7.518507e-01 | 0.124 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 7.541759e-01 | 0.123 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 7.603747e-01 | 0.119 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 7.630428e-01 | 0.117 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 7.630428e-01 | 0.117 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 7.655361e-01 | 0.116 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 7.655361e-01 | 0.116 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 7.655361e-01 | 0.116 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 7.668435e-01 | 0.115 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 7.668435e-01 | 0.115 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 7.668435e-01 | 0.115 | 0 | 0 |
| Diseases of branched-chain amino acid catabolism | R-HSA-9865118 | 7.668435e-01 | 0.115 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 7.668435e-01 | 0.115 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 7.668435e-01 | 0.115 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 7.725622e-01 | 0.112 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 7.725622e-01 | 0.112 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 7.725622e-01 | 0.112 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 7.725622e-01 | 0.112 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 7.725622e-01 | 0.112 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 7.725622e-01 | 0.112 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 7.725622e-01 | 0.112 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 7.725622e-01 | 0.112 | 0 | 0 |
| Acyl chain remodeling of DAG and TAG | R-HSA-1482883 | 7.725622e-01 | 0.112 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 7.725622e-01 | 0.112 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 7.725622e-01 | 0.112 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 7.729918e-01 | 0.112 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 7.764821e-01 | 0.110 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 7.764821e-01 | 0.110 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 7.764821e-01 | 0.110 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 7.813958e-01 | 0.107 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 7.813958e-01 | 0.107 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 7.813958e-01 | 0.107 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 7.870204e-01 | 0.104 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 7.874170e-01 | 0.104 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 7.874170e-01 | 0.104 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 7.897695e-01 | 0.102 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 7.915462e-01 | 0.102 | 0 | 0 |
| BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | R-HSA-9859138 | 7.915462e-01 | 0.102 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.915462e-01 | 0.102 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 7.915462e-01 | 0.102 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 7.915462e-01 | 0.102 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 7.915462e-01 | 0.102 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 7.915462e-01 | 0.102 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 7.915462e-01 | 0.102 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 7.915462e-01 | 0.102 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 7.915462e-01 | 0.102 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 7.951444e-01 | 0.100 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 7.951444e-01 | 0.100 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 7.951444e-01 | 0.100 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 7.971035e-01 | 0.098 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 7.971580e-01 | 0.098 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 7.988029e-01 | 0.098 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 8.007064e-01 | 0.097 | 1 | 0 |
| Platelet homeostasis | R-HSA-418346 | 8.044177e-01 | 0.095 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 8.069027e-01 | 0.093 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 8.069027e-01 | 0.093 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 8.069027e-01 | 0.093 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 8.069027e-01 | 0.093 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 8.077522e-01 | 0.093 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 8.077522e-01 | 0.093 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 8.081222e-01 | 0.093 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 8.081222e-01 | 0.093 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 8.081222e-01 | 0.093 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 8.081222e-01 | 0.093 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 8.089467e-01 | 0.092 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 8.089467e-01 | 0.092 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 8.089467e-01 | 0.092 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 8.089467e-01 | 0.092 | 0 | 0 |
| Dopamine clearance from the synaptic cleft | R-HSA-379401 | 8.089467e-01 | 0.092 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 8.089467e-01 | 0.092 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 8.089467e-01 | 0.092 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 8.089467e-01 | 0.092 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 8.089467e-01 | 0.092 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 8.089467e-01 | 0.092 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 8.104589e-01 | 0.091 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 8.153819e-01 | 0.089 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 8.200434e-01 | 0.086 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 8.203619e-01 | 0.086 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 8.203619e-01 | 0.086 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 8.203619e-01 | 0.086 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 8.203619e-01 | 0.086 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 8.217549e-01 | 0.085 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.248956e-01 | 0.084 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 8.248956e-01 | 0.084 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 8.248956e-01 | 0.084 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 8.248956e-01 | 0.084 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 8.248956e-01 | 0.084 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 8.248956e-01 | 0.084 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 8.248956e-01 | 0.084 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 8.248956e-01 | 0.084 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 8.248956e-01 | 0.084 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 8.248956e-01 | 0.084 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 8.248956e-01 | 0.084 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 8.248956e-01 | 0.084 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.248956e-01 | 0.084 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 8.250356e-01 | 0.084 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 8.252465e-01 | 0.083 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 8.252465e-01 | 0.083 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 8.252465e-01 | 0.083 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 8.258445e-01 | 0.083 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 8.267435e-01 | 0.083 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 8.277202e-01 | 0.082 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 8.318963e-01 | 0.080 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 8.318963e-01 | 0.080 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 8.318963e-01 | 0.080 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 8.318963e-01 | 0.080 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 8.324056e-01 | 0.080 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 8.338633e-01 | 0.079 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 8.338633e-01 | 0.079 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 8.368292e-01 | 0.077 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 8.393429e-01 | 0.076 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 8.393429e-01 | 0.076 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 8.393429e-01 | 0.076 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 8.395139e-01 | 0.076 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.395139e-01 | 0.076 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.395139e-01 | 0.076 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 8.395139e-01 | 0.076 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 8.395139e-01 | 0.076 | 0 | 0 |
| Fibronectin matrix formation | R-HSA-1566977 | 8.395139e-01 | 0.076 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 8.395139e-01 | 0.076 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 8.395139e-01 | 0.076 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 8.395139e-01 | 0.076 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 8.395139e-01 | 0.076 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 8.395139e-01 | 0.076 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 8.395139e-01 | 0.076 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 8.400279e-01 | 0.076 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 8.421224e-01 | 0.075 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 8.421224e-01 | 0.075 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 8.421224e-01 | 0.075 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 8.421224e-01 | 0.075 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 8.421224e-01 | 0.075 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 8.424245e-01 | 0.074 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 8.427578e-01 | 0.074 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 8.427578e-01 | 0.074 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 8.427578e-01 | 0.074 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 8.470715e-01 | 0.072 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 8.473629e-01 | 0.072 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 8.529127e-01 | 0.069 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.529127e-01 | 0.069 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 8.529127e-01 | 0.069 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 8.529127e-01 | 0.069 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 8.529127e-01 | 0.069 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 8.529127e-01 | 0.069 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 8.529127e-01 | 0.069 | 0 | 0 |
| GDP-fucose biosynthesis | R-HSA-6787639 | 8.529127e-01 | 0.069 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.529127e-01 | 0.069 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 8.529127e-01 | 0.069 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 8.529785e-01 | 0.069 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 8.529785e-01 | 0.069 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 8.529785e-01 | 0.069 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 8.537538e-01 | 0.069 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 8.576061e-01 | 0.067 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 8.599640e-01 | 0.066 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 8.625894e-01 | 0.064 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 8.625894e-01 | 0.064 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 8.625894e-01 | 0.064 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 8.625894e-01 | 0.064 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 8.648504e-01 | 0.063 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.649269e-01 | 0.063 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 8.651936e-01 | 0.063 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.651936e-01 | 0.063 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 8.651936e-01 | 0.063 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 8.651936e-01 | 0.063 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.651936e-01 | 0.063 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 8.651936e-01 | 0.063 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 8.651936e-01 | 0.063 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 8.651936e-01 | 0.063 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.651936e-01 | 0.063 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 8.677116e-01 | 0.062 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 8.716212e-01 | 0.060 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 8.716212e-01 | 0.060 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 8.716212e-01 | 0.060 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 8.716212e-01 | 0.060 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 8.716212e-01 | 0.060 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 8.716212e-01 | 0.060 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 8.716212e-01 | 0.060 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 8.716212e-01 | 0.060 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 8.716212e-01 | 0.060 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 8.716212e-01 | 0.060 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 8.716212e-01 | 0.060 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 8.726211e-01 | 0.059 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 8.726211e-01 | 0.059 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 8.734282e-01 | 0.059 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.764497e-01 | 0.057 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 8.764497e-01 | 0.057 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 8.764497e-01 | 0.057 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 8.764497e-01 | 0.057 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 8.764497e-01 | 0.057 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 8.764497e-01 | 0.057 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 8.764497e-01 | 0.057 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 8.773039e-01 | 0.057 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 8.799247e-01 | 0.056 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 8.801035e-01 | 0.055 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 8.801035e-01 | 0.055 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 8.801035e-01 | 0.055 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 8.867666e-01 | 0.052 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.867666e-01 | 0.052 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 8.867666e-01 | 0.052 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 8.867666e-01 | 0.052 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 8.867666e-01 | 0.052 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 8.867666e-01 | 0.052 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 8.867666e-01 | 0.052 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.867666e-01 | 0.052 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.867666e-01 | 0.052 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 8.867666e-01 | 0.052 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.867666e-01 | 0.052 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 8.934225e-01 | 0.049 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 8.955338e-01 | 0.048 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 8.955338e-01 | 0.048 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 8.955338e-01 | 0.048 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 8.962226e-01 | 0.048 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 8.962226e-01 | 0.048 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 8.962226e-01 | 0.048 | 0 | 0 |
| Matriglycan biosynthesis on DAG1 | R-HSA-9939291 | 8.962226e-01 | 0.048 | 0 | 0 |
| Phenylalanine metabolism | R-HSA-8964208 | 8.962226e-01 | 0.048 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 8.962226e-01 | 0.048 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.962226e-01 | 0.048 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 8.962226e-01 | 0.048 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 9.048894e-01 | 0.043 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 9.048894e-01 | 0.043 | 0 | 0 |
| Molybdenum cofactor biosynthesis | R-HSA-947581 | 9.048894e-01 | 0.043 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 9.048894e-01 | 0.043 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 9.048894e-01 | 0.043 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 9.088072e-01 | 0.042 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.090985e-01 | 0.041 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 9.090985e-01 | 0.041 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.110695e-01 | 0.040 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.116996e-01 | 0.040 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.116996e-01 | 0.040 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 9.121861e-01 | 0.040 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 9.121861e-01 | 0.040 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.121861e-01 | 0.040 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 9.122518e-01 | 0.040 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 9.128329e-01 | 0.040 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 9.128329e-01 | 0.040 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 9.128329e-01 | 0.040 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 9.128329e-01 | 0.040 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 9.128329e-01 | 0.040 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 9.150563e-01 | 0.039 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 9.152449e-01 | 0.038 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 9.152449e-01 | 0.038 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 9.152449e-01 | 0.038 | 0 | 0 |
| Maturation of TCA enzymes and regulation of TCA cycle | R-HSA-9854311 | 9.152449e-01 | 0.038 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 9.152449e-01 | 0.038 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 9.152449e-01 | 0.038 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.155026e-01 | 0.038 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.201134e-01 | 0.036 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 9.201134e-01 | 0.036 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 9.201134e-01 | 0.036 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 9.201134e-01 | 0.036 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.201134e-01 | 0.036 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.201134e-01 | 0.036 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.209992e-01 | 0.036 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.209992e-01 | 0.036 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.209992e-01 | 0.036 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 9.209992e-01 | 0.036 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 9.209992e-01 | 0.036 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 9.236045e-01 | 0.035 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 9.257202e-01 | 0.034 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 9.263841e-01 | 0.033 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 9.267862e-01 | 0.033 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.267862e-01 | 0.033 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.267862e-01 | 0.033 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.276546e-01 | 0.033 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.305651e-01 | 0.031 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.311799e-01 | 0.031 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 9.313453e-01 | 0.031 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.314210e-01 | 0.031 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.329020e-01 | 0.030 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.329020e-01 | 0.030 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.329020e-01 | 0.030 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.329020e-01 | 0.030 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 9.329020e-01 | 0.030 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 9.329020e-01 | 0.030 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 9.329020e-01 | 0.030 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.361306e-01 | 0.029 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 9.373317e-01 | 0.028 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 9.373464e-01 | 0.028 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.373464e-01 | 0.028 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.385073e-01 | 0.028 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 9.385073e-01 | 0.028 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 9.385073e-01 | 0.028 | 0 | 0 |
| Linoleic acid (LA) metabolism | R-HSA-2046105 | 9.385073e-01 | 0.028 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 9.385073e-01 | 0.028 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.385073e-01 | 0.028 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 9.387441e-01 | 0.027 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.387441e-01 | 0.027 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.405323e-01 | 0.027 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 9.409519e-01 | 0.026 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 9.424906e-01 | 0.026 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 9.424906e-01 | 0.026 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 9.424906e-01 | 0.026 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 9.436446e-01 | 0.025 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 9.436446e-01 | 0.025 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 9.436446e-01 | 0.025 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.436446e-01 | 0.025 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.436446e-01 | 0.025 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.436446e-01 | 0.025 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.441515e-01 | 0.025 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 9.444807e-01 | 0.025 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 9.446446e-01 | 0.025 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.446446e-01 | 0.025 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 9.446446e-01 | 0.025 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 9.446446e-01 | 0.025 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 9.460235e-01 | 0.024 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 9.467952e-01 | 0.024 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 9.483530e-01 | 0.023 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 9.483530e-01 | 0.023 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 9.483530e-01 | 0.023 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.483530e-01 | 0.023 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.484853e-01 | 0.023 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.484853e-01 | 0.023 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 9.484853e-01 | 0.023 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.486788e-01 | 0.023 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 9.493538e-01 | 0.023 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 9.526683e-01 | 0.021 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 9.526683e-01 | 0.021 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 9.526683e-01 | 0.021 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 9.526683e-01 | 0.021 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 9.526683e-01 | 0.021 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 9.533984e-01 | 0.021 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.553022e-01 | 0.020 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.553022e-01 | 0.020 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 9.566232e-01 | 0.019 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.566232e-01 | 0.019 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 9.566232e-01 | 0.019 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 9.582300e-01 | 0.019 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.585393e-01 | 0.018 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.585393e-01 | 0.018 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.599578e-01 | 0.018 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.614394e-01 | 0.017 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.614512e-01 | 0.017 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 9.635700e-01 | 0.016 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.635700e-01 | 0.016 | 0 | 0 |
| DAG1 glycosylations | R-HSA-8931838 | 9.635700e-01 | 0.016 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.635700e-01 | 0.016 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.641661e-01 | 0.016 | 0 | 0 |
| Branched-chain amino acid catabolism | R-HSA-70895 | 9.641661e-01 | 0.016 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.656309e-01 | 0.015 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 9.666145e-01 | 0.015 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 9.666145e-01 | 0.015 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 9.666145e-01 | 0.015 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 9.678099e-01 | 0.014 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.690549e-01 | 0.014 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 9.690549e-01 | 0.014 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.694048e-01 | 0.013 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.694048e-01 | 0.013 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 9.694048e-01 | 0.013 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.698579e-01 | 0.013 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 9.714112e-01 | 0.013 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.719621e-01 | 0.012 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 9.719621e-01 | 0.012 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 9.719621e-01 | 0.012 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 9.719621e-01 | 0.012 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.719621e-01 | 0.012 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 9.719621e-01 | 0.012 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.730739e-01 | 0.012 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.735898e-01 | 0.012 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 9.740354e-01 | 0.011 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.743057e-01 | 0.011 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 9.743057e-01 | 0.011 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 9.743057e-01 | 0.011 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 9.743057e-01 | 0.011 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.743057e-01 | 0.011 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.752871e-01 | 0.011 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.764536e-01 | 0.010 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 9.764536e-01 | 0.010 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.764536e-01 | 0.010 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 9.764536e-01 | 0.010 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 9.764536e-01 | 0.010 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.764536e-01 | 0.010 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.772116e-01 | 0.010 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.772116e-01 | 0.010 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.784220e-01 | 0.009 | 0 | 0 |
| Phenylalanine and tyrosine metabolism | R-HSA-8963691 | 9.784220e-01 | 0.009 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.784220e-01 | 0.009 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.798611e-01 | 0.009 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 9.801613e-01 | 0.009 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.801613e-01 | 0.009 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.801613e-01 | 0.009 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.801613e-01 | 0.009 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 9.802260e-01 | 0.009 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.802260e-01 | 0.009 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.815894e-01 | 0.008 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.818793e-01 | 0.008 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.818793e-01 | 0.008 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 9.818793e-01 | 0.008 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 9.822941e-01 | 0.008 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 9.833944e-01 | 0.007 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 9.833944e-01 | 0.007 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 9.834842e-01 | 0.007 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.847829e-01 | 0.007 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.850724e-01 | 0.007 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.855836e-01 | 0.006 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.857401e-01 | 0.006 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 9.860554e-01 | 0.006 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.860554e-01 | 0.006 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.860554e-01 | 0.006 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.860554e-01 | 0.006 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.869861e-01 | 0.006 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.872216e-01 | 0.006 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.872216e-01 | 0.006 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.882792e-01 | 0.005 | 0 | 0 |
| Synthesis of very long-chain fatty acyl-CoAs | R-HSA-75876 | 9.882903e-01 | 0.005 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 9.885711e-01 | 0.005 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.887690e-01 | 0.005 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.889398e-01 | 0.005 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.891346e-01 | 0.005 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 9.892697e-01 | 0.005 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 9.892697e-01 | 0.005 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 9.892697e-01 | 0.005 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.892697e-01 | 0.005 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.892697e-01 | 0.005 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.901672e-01 | 0.004 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.901672e-01 | 0.004 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 9.909897e-01 | 0.004 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.916914e-01 | 0.004 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.917434e-01 | 0.004 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.917434e-01 | 0.004 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.919866e-01 | 0.003 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.930438e-01 | 0.003 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.931236e-01 | 0.003 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.936472e-01 | 0.003 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.941021e-01 | 0.003 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.941021e-01 | 0.003 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.941787e-01 | 0.003 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.941787e-01 | 0.003 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.943977e-01 | 0.002 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 9.953192e-01 | 0.002 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.953192e-01 | 0.002 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.953192e-01 | 0.002 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.960574e-01 | 0.002 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.962889e-01 | 0.002 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.964343e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.965544e-01 | 0.001 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.965544e-01 | 0.001 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.965675e-01 | 0.001 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.968226e-01 | 0.001 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.971071e-01 | 0.001 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.973071e-01 | 0.001 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.973493e-01 | 0.001 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.973493e-01 | 0.001 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.973493e-01 | 0.001 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.973533e-01 | 0.001 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.974248e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.975740e-01 | 0.001 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.977216e-01 | 0.001 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.979609e-01 | 0.001 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.981317e-01 | 0.001 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.982072e-01 | 0.001 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.982881e-01 | 0.001 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.984402e-01 | 0.001 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.985628e-01 | 0.001 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.985880e-01 | 0.001 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.986832e-01 | 0.001 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.986832e-01 | 0.001 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.988525e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.988851e-01 | 0.000 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.988946e-01 | 0.000 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 9.988946e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.989872e-01 | 0.000 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.989872e-01 | 0.000 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 9.990720e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.992128e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.992128e-01 | 0.000 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 9.992863e-01 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.993275e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.994511e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.994971e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.998439e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.998460e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.998730e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.998762e-01 | 0.000 | 0 | 0 |
| Scavenging of heme from plasma | R-HSA-2168880 | 9.999048e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.999329e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.999486e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999559e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.999612e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999748e-01 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 9.999756e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999766e-01 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.999786e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999795e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999816e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999947e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999948e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.999968e-01 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.999968e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999974e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999977e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999979e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999979e-01 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 9.999983e-01 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 9.999994e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999996e-01 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 9.999998e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999999e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 1 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
