WNK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
B2RPK0 S121 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 AFFLFCSEYHPKIKGEHPGLsIGDVAKKLGEMWNNTAADDK
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O60841 S178 Sugiyama EIF5B IF2 KIAA0741 NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 T78 Sugiyama EIF5B IF2 KIAA0741 ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O94913 S120 EPSD|PSP PCF11 KIAA0824 FICVFEKVDENTRKSLFKLRstWDEIFPLKKLYALDVRVNS
O94913 T121 EPSD|PSP PCF11 KIAA0824 ICVFEKVDENTRKSLFKLRstWDEIFPLKKLYALDVRVNSL
O95218 T50 Sugiyama ZRANB2 ZIS ZNF265 SCNRCGREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQ
O95218 T55 Sugiyama ZRANB2 ZIS ZNF265 GREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQCKTCs
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95747 S325 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP OXSR1 KIAA1101 OSR1 LQRAPtISERAKKVRRVPGssGRLHKtEDGGWEWsDDEFDE
O95747 T185 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP OXSR1 KIAA1101 OSR1 FGVSAFLATGGDITRNKVRKtFVGTPCWMAPEVMEQVRGYD
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04920 S65 Sugiyama SLC4A2 AE2 EPB3L1 HKB3 MPB3L ERFEEILQEAGsRGGEEPGRsYGEEDFEyHRQSSHHIHHPL
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06748 S260 Sugiyama NPM1 NPM GPssVEDIKAKMQAsIEKGGsLPKVEAKFINyVKNCFRMtD
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09429 S121 Sugiyama HMGB1 HMG1 AFFLFCSEYRPKIKGEHPGLsIGDVAKKLGEMWNNTAADDK
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S55 Sugiyama PKM OIP3 PK2 PK3 PKM2 IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S551 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P20290 S173 Sugiyama BTF3 NACB OK/SW-cl.8 QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P25705 S76 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P25789 S7 Sugiyama PSMA4 HC9 PSC9 ______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789 Y5 Sugiyama PSMA4 HC9 PSC9 ________________MSRRyDsRttIFsPEGRLYQVEYAM
P26232 S667 Sugiyama CTNNA2 CAPR YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29144 S93 Sugiyama TPP2 SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S74 Sugiyama EEF1D EF1D RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P29692 T129 Sugiyama EEF1D EF1D EARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPA
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P29692 T73 Sugiyama EEF1D EF1D ARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQs
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35221 S668 Sugiyama CTNNA1 FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P36578 S365 Sugiyama RPL4 RPL1 RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T111 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P46013 S651 Sugiyama MKI67 ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776 S106 Sugiyama RPL27A tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 T72 Sugiyama RPL27A yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776 Y108 Sugiyama RPL27A VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47914 S142 Sugiyama RPL29 KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P47914 T151 Sugiyama RPL29 DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P47914 Y98 Sugiyama RPL29 PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49321 S662 Sugiyama NASP LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P50238 Y12 Sugiyama CRIP1 CRIP CRP1 _________MPKCPKCNKEVyFAERVTSLGKDWHRPCLKCE
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55011 T1023 SIGNOR SLC12A2 NKCC1 VADQKLLEASTQFQKKQGKNtIDVWWLFDDGGLTLLIPYLL
P57721 S59 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT EGGLNVTLTIRLLMHGKEVGsIIGKKGETVKKMREESGARI
P57723 S31 Sugiyama PCBP4 EPELSITLTLRMLMHGKEVGsIIGKKGETVKRIREQSSARI
P60174 S106 Sugiyama TPI1 TPI DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S167 Sugiyama YBX1 NSEP1 YB1 RYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRP
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02878 S255 Sugiyama RPL6 TXREB1 tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13428 S1410 Sugiyama TCOF1 AKRDKASGDVKEKKGKGsLGsQGAKDEPEEELQKGMGTVEG
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q15185 S82 Sugiyama PTGES3 P23 TEBP NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15365 S27 Sugiyama PCBP1 ESGLNVTLTIRLLMHGKEVGsIIGKKGESVKRIREEsGARI
Q15366 S27 Sugiyama PCBP2 EGGLNVTLTIRLLMHGKEVGsIIGKKGESVKKMREESGARI
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7Z4V5 S369 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q7Z4V5 S396 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKP
Q86V81 S142 Sugiyama ALYREF ALY BEF THOC4 IQELFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKA
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N9I0 T199 SIGNOR SYT2 VKVFLLPDKKKKYETKVHRKtLNPAFNETFTFKVPYQELGG
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q96CT7 S122 Sugiyama CCDC124 DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96J92 S335 Sugiyama WNK4 PRKWNK4 GsVKIGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDEA
Q96J92 T339 Sugiyama WNK4 PRKWNK4 IGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDEAVDVY
Q96PU5 S342 GPS6|EPSD NEDD4L KIAA0439 NEDL3 NGEQFsSLIQREPssRLRsCsVtDAVAEQGHLPPPSAPAGR
Q96PU5 S449 GPS6|EPSD NEDD4L KIAA0439 NEDL3 ATNSNNHLIEPQIRRPRsLssPtVTLSAPLEGAKDsPVRRA
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYP7 T287 Sugiyama WNK3 KIAA1566 PRKWNK3 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLMRtsFAK
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H4A3 S10 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 ___________MsGGAAEKQsstPGsLFLsPPAPAPKNGSs
Q9H4A3 S11 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 __________MsGGAAEKQsstPGsLFLsPPAPAPKNGSss
Q9H4A3 S15 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 ______MsGGAAEKQsstPGsLFLsPPAPAPKNGSssDssV
Q9H4A3 S167 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 AVAGPAPSTVPSSTSKDRPVsQPsLVGsKEEPPPARsGsGG
Q9H4A3 S170 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GPAPSTVPSSTSKDRPVsQPsLVGsKEEPPPARsGsGGGsA
Q9H4A3 S19 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 __MsGGAAEKQsstPGsLFLsPPAPAPKNGSssDssVGEKL
Q9H4A3 S198 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 PPPARsGsGGGsAKEPQEERsQQQDDIEELEtKAVGMSNDG
Q9H4A3 S378 GPS6 WNK1 HSN2 KDP KIAA0344 PRKWNK1 tGPtGsVKIGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEK
Q9H4A3 S382 GPS6|SIGNOR|EPSD|PSP|Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GsVKIGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDES
Q9H4A3 T12 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 _________MsGGAAEKQsstPGsLFLsPPAPAPKNGSssD
Q9H4A3 T209 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 sAKEPQEERsQQQDDIEELEtKAVGMSNDGRFLKFDIEIGR
Q9H4A3 T361 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAK
Q9H4A3 T386 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 IGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDESVDVY
Q9H4A3 T48 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GSssDssVGEKLGAAAADAVtGRtEEyRRRRHtMDKDSRGA
Q9H4A3 T51 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 sDssVGEKLGAAAADAVtGRtEEyRRRRHtMDKDSRGAAAt
Q9H4A3 T71 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 tEEyRRRRHtMDKDSRGAAAtTtTTEHRFFRRsVICDSNAT
Q9H4A3 T73 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 EyRRRRHtMDKDSRGAAAtTtTTEHRFFRRsVICDSNATAL
Q9H4A3 Y54 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 sVGEKLGAAAADAVtGRtEEyRRRRHtMDKDSRGAAAtTtT
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NYF8 S319 Sugiyama BCLAF1 BTF KIAA0164 RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9UEW8 S371 GPS6|SIGNOR|EPSD|PSP STK39 PASK SPAK LtRtPDIAQRAKKVRRVPGssGHLHKTEDGDWEWsDDEMDE
Q9UEW8 T231 GPS6|SIGNOR|EPSD|PSP STK39 PASK SPAK FGVSAFLATGGDVTRNKVRKtFVGTPCWMAPEVMEQVRGYD
Q9UGY1 S21 Sugiyama NOL12 MGRNKKKKRDGDDRRPRLVLsFDEEKRREyLTGFHKRKVER
Q9UHW9 T1048 SIGNOR|EPSD|PSP SLC12A6 KCC3 tsIGsDEDEEtETYQEKVHMtWTKDKYMASRGQKAKsMEGF
Q9UHW9 T991 SIGNOR|EPSD|PSP SLC12A6 KCC3 AEVEVVEMHDSDISAYTYERtLMMEQRSQMLRHMRLSKTER
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3S1 T335 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAK
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Q9Y5M8 S257 Sugiyama SRPRB PSEC0230 LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 9.992007e-16 15.000 0 0
Cell Cycle, Mitotic R-HSA-69278 4.162226e-13 12.381 0 0
Axon guidance R-HSA-422475 4.034728e-11 10.394 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.812274e-10 9.742 0 0
Signal Transduction R-HSA-162582 2.727164e-10 9.564 0 0
Nervous system development R-HSA-9675108 1.325785e-09 8.878 0 0
M Phase R-HSA-68886 2.186537e-09 8.660 0 0
Cellular Senescence R-HSA-2559583 4.793688e-09 8.319 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.132769e-08 7.946 0 0
Mitotic Prometaphase R-HSA-68877 4.559356e-08 7.341 0 0
Cell Cycle Checkpoints R-HSA-69620 5.673512e-08 7.246 0 0
Post NMDA receptor activation events R-HSA-438064 2.029990e-07 6.693 0 0
Apoptotic execution phase R-HSA-75153 3.696342e-07 6.432 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.024944e-06 5.989 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.061426e-06 5.974 0 0
Chromatin modifying enzymes R-HSA-3247509 1.129698e-06 5.947 0 0
Chromatin organization R-HSA-4839726 2.016303e-06 5.695 0 0
EPH-Ephrin signaling R-HSA-2682334 2.117235e-06 5.674 0 0
Regulation of TP53 Activity R-HSA-5633007 2.296898e-06 5.639 0 0
Kinesins R-HSA-983189 2.289934e-06 5.640 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.021598e-06 5.520 0 0
Gene expression (Transcription) R-HSA-74160 4.687644e-06 5.329 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.603505e-06 5.337 0 0
Mitotic Anaphase R-HSA-68882 6.125018e-06 5.213 0 0
Cellular responses to stimuli R-HSA-8953897 6.266791e-06 5.203 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.978198e-06 5.156 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.939439e-06 5.159 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.283814e-06 5.138 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.607820e-06 5.119 0 0
Cellular responses to stress R-HSA-2262752 7.656860e-06 5.116 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.597046e-06 5.018 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.116922e-05 4.952 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.161505e-05 4.935 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.219028e-05 4.914 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.215320e-05 4.915 0 0
Recycling pathway of L1 R-HSA-437239 1.694224e-05 4.771 0 0
HSF1-dependent transactivation R-HSA-3371571 1.642452e-05 4.785 0 0
RNA Polymerase II Transcription R-HSA-73857 1.691637e-05 4.772 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.789292e-05 4.747 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.850186e-05 4.733 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.128476e-05 4.672 0 0
ESR-mediated signaling R-HSA-8939211 2.098100e-05 4.678 0 0
Cellular response to heat stress R-HSA-3371556 2.809917e-05 4.551 0 0
Signaling by VEGF R-HSA-194138 2.840161e-05 4.547 0 0
Ephrin signaling R-HSA-3928664 3.088319e-05 4.510 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.001216e-05 4.523 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.063214e-05 4.514 0 0
Separation of Sister Chromatids R-HSA-2467813 3.509938e-05 4.455 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.704330e-05 4.328 0 0
Attenuation phase R-HSA-3371568 5.364234e-05 4.270 0 0
NRAGE signals death through JNK R-HSA-193648 5.570047e-05 4.254 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.750146e-05 4.240 0 0
Developmental Biology R-HSA-1266738 5.943108e-05 4.226 0 0
mRNA 3'-end processing R-HSA-72187 6.006726e-05 4.221 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.017597e-05 4.221 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.385003e-05 4.195 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.766616e-05 4.170 0 0
RMTs methylate histone arginines R-HSA-3214858 6.766616e-05 4.170 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.035603e-05 4.153 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.919467e-05 4.101 0 0
G2/M Transition R-HSA-69275 8.577553e-05 4.067 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.152587e-05 4.038 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.171747e-04 3.931 0 0
Generic Transcription Pathway R-HSA-212436 1.157650e-04 3.936 0 0
G alpha (12/13) signalling events R-HSA-416482 1.234713e-04 3.908 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.602612e-04 3.795 0 0
Aggrephagy R-HSA-9646399 1.602612e-04 3.795 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.678000e-04 3.775 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.672254e-04 3.777 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.706679e-04 3.768 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.788036e-04 3.748 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.838576e-04 3.736 0 0
Rap1 signalling R-HSA-392517 1.890127e-04 3.724 0 0
Meiotic synapsis R-HSA-1221632 2.025856e-04 3.693 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.177290e-04 3.662 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.177290e-04 3.662 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.313622e-04 3.636 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.288858e-04 3.640 0 0
Signaling by ALK in cancer R-HSA-9700206 2.288858e-04 3.640 0 0
L1CAM interactions R-HSA-373760 2.585281e-04 3.587 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.615185e-04 3.582 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.758143e-04 3.559 0 0
FOXO-mediated transcription R-HSA-9614085 2.661912e-04 3.575 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.944899e-04 3.531 0 0
HDACs deacetylate histones R-HSA-3214815 3.082090e-04 3.511 0 0
G2/M Checkpoints R-HSA-69481 3.236385e-04 3.490 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.441555e-04 3.463 0 0
Centrosome maturation R-HSA-380287 3.915299e-04 3.407 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.766554e-04 3.424 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.027411e-04 3.395 0 0
Meiosis R-HSA-1500620 4.105680e-04 3.387 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.492640e-04 3.347 0 0
Mitotic Prophase R-HSA-68875 4.419870e-04 3.355 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.898336e-04 3.310 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.956876e-04 3.305 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.956876e-04 3.305 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.097464e-04 3.293 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.187096e-04 3.285 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.623440e-04 3.250 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.339159e-04 3.273 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.882847e-04 3.230 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.882847e-04 3.230 0 0
Semaphorin interactions R-HSA-373755 5.882847e-04 3.230 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.006402e-04 3.221 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.084415e-04 3.216 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.320124e-04 3.199 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.412927e-04 3.193 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.448210e-04 3.191 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.486480e-04 3.188 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.930177e-04 3.101 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.786906e-04 3.109 0 0
Muscle contraction R-HSA-397014 7.975109e-04 3.098 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.338710e-04 3.079 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.444327e-04 3.073 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.945715e-04 3.048 0 0
Signaling by ROBO receptors R-HSA-376176 8.978325e-04 3.047 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.126925e-04 3.040 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.809165e-04 3.008 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.584294e-04 3.018 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.838656e-04 3.007 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.028975e-03 2.988 0 0
Oncogene Induced Senescence R-HSA-2559585 1.079037e-03 2.967 0 0
HATs acetylate histones R-HSA-3214847 1.129532e-03 2.947 0 0
Apoptosis R-HSA-109581 1.162143e-03 2.935 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.173992e-03 2.930 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.191305e-03 2.924 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.246741e-03 2.904 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.353745e-03 2.868 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.381395e-03 2.860 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.450411e-03 2.839 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.483430e-03 2.829 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.483430e-03 2.829 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.483430e-03 2.829 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.483430e-03 2.829 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.519911e-03 2.818 0 0
Diseases of programmed cell death R-HSA-9645723 1.577615e-03 2.802 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.603862e-03 2.795 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.720714e-03 2.764 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.602135e-03 2.795 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.700991e-03 2.769 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.763210e-03 2.754 0 0
mRNA Splicing R-HSA-72172 1.793268e-03 2.746 0 0
Striated Muscle Contraction R-HSA-390522 1.865164e-03 2.729 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.865164e-03 2.729 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.978700e-03 2.704 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.070933e-03 2.684 0 0
Ion homeostasis R-HSA-5578775 2.142031e-03 2.669 0 0
Metalloprotease DUBs R-HSA-5689901 2.201774e-03 2.657 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.202264e-03 2.657 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.219612e-03 2.654 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.325421e-03 2.633 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.480986e-03 2.605 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.551684e-03 2.593 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.576885e-03 2.589 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.750295e-03 2.561 0 0
Packaging Of Telomere Ends R-HSA-171306 2.813947e-03 2.551 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.874537e-03 2.541 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.932917e-03 2.533 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.107063e-03 2.508 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.111336e-03 2.507 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.173005e-03 2.499 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.189878e-03 2.496 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.526341e-03 2.453 0 0
HSF1 activation R-HSA-3371511 3.526341e-03 2.453 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.491064e-03 2.457 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.492598e-03 2.457 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.213945e-03 2.493 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.210381e-03 2.493 0 0
Ub-specific processing proteases R-HSA-5689880 3.620981e-03 2.441 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.758185e-03 2.425 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.758185e-03 2.425 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.758185e-03 2.425 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.883743e-03 2.411 0 0
DAG and IP3 signaling R-HSA-1489509 3.919015e-03 2.407 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.943429e-03 2.404 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.978104e-03 2.400 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.045323e-03 2.393 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.045323e-03 2.393 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.073789e-03 2.390 0 0
Signaling by ERBB2 R-HSA-1227986 4.073789e-03 2.390 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.073789e-03 2.390 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.251135e-03 2.371 0 0
DNA methylation R-HSA-5334118 4.451735e-03 2.351 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.451735e-03 2.351 0 0
Platelet calcium homeostasis R-HSA-418360 4.451735e-03 2.351 0 0
Meiotic recombination R-HSA-912446 4.736677e-03 2.325 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.909963e-03 2.309 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.909963e-03 2.309 0 0
Programmed Cell Death R-HSA-5357801 5.051340e-03 2.297 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.191564e-03 2.285 0 0
Activation of RAC1 R-HSA-428540 5.682444e-03 2.245 0 0
Reproduction R-HSA-1474165 5.764741e-03 2.239 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.873674e-03 2.231 0 0
PI Metabolism R-HSA-1483255 5.930050e-03 2.227 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.945587e-03 2.226 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.945587e-03 2.226 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.945587e-03 2.226 0 0
Deubiquitination R-HSA-5688426 6.078122e-03 2.216 0 0
Selective autophagy R-HSA-9663891 6.092487e-03 2.215 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.180728e-03 2.209 0 0
TRP channels R-HSA-3295583 6.180728e-03 2.209 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.485434e-03 2.188 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.374721e-03 2.132 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.616176e-03 2.179 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.967447e-03 2.157 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.374721e-03 2.132 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.159305e-03 2.145 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.434514e-03 2.129 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.438721e-03 2.129 0 0
PKR-mediated signaling R-HSA-9833482 7.475710e-03 2.126 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.671910e-03 2.115 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.939473e-03 2.100 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.939473e-03 2.100 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.058596e-03 2.094 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.437886e-03 2.074 0 0
Calmodulin induced events R-HSA-111933 8.620579e-03 2.064 0 0
CaM pathway R-HSA-111997 8.620579e-03 2.064 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.820719e-03 2.054 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.886637e-03 2.051 0 0
Nucleosome assembly R-HSA-774815 8.886637e-03 2.051 0 0
Cilium Assembly R-HSA-5617833 8.986475e-03 2.046 0 0
Cell-Cell communication R-HSA-1500931 9.051510e-03 2.043 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.520277e-03 2.021 0 0
Integrin signaling R-HSA-354192 9.965620e-03 2.001 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.506698e-03 2.022 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.506698e-03 2.022 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.506698e-03 2.022 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.037558e-02 1.984 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.459693e-03 2.024 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.459693e-03 2.024 0 0
MAPK family signaling cascades R-HSA-5683057 9.120012e-03 2.040 0 0
Cleavage of the damaged purine R-HSA-110331 1.027207e-02 1.988 0 0
Signaling by Interleukins R-HSA-449147 9.363109e-03 2.029 0 0
Signaling by RAS mutants R-HSA-6802949 1.038320e-02 1.984 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.038320e-02 1.984 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.038320e-02 1.984 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.038320e-02 1.984 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.050159e-02 1.979 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.050159e-02 1.979 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.050159e-02 1.979 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.050159e-02 1.979 0 0
Neuronal System R-HSA-112316 1.056419e-02 1.976 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.062720e-02 1.974 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.062720e-02 1.974 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.063898e-02 1.973 0 0
DNA Double Strand Break Response R-HSA-5693606 1.079612e-02 1.967 0 0
Gene Silencing by RNA R-HSA-211000 1.107953e-02 1.955 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.119144e-02 1.951 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.154809e-02 1.937 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.194209e-02 1.923 0 0
Depurination R-HSA-73927 1.216003e-02 1.915 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.221493e-02 1.913 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.221493e-02 1.913 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.223807e-02 1.912 0 0
S Phase R-HSA-69242 1.226734e-02 1.911 0 0
Death Receptor Signaling R-HSA-73887 1.242000e-02 1.906 0 0
HDMs demethylate histones R-HSA-3214842 1.316136e-02 1.881 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.316136e-02 1.881 0 0
Long-term potentiation R-HSA-9620244 1.316136e-02 1.881 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.385710e-02 1.858 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.394368e-02 1.856 0 0
Co-stimulation by CD28 R-HSA-389356 1.396631e-02 1.855 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.497837e-02 1.825 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.430527e-02 1.845 0 0
Translation initiation complex formation R-HSA-72649 1.559646e-02 1.807 0 0
Netrin-1 signaling R-HSA-373752 1.647525e-02 1.783 0 0
Hedgehog 'off' state R-HSA-5610787 1.524027e-02 1.817 0 0
Nuclear import of Rev protein R-HSA-180746 1.421051e-02 1.847 0 0
Defective pyroptosis R-HSA-9710421 1.420696e-02 1.847 0 0
Interleukin-12 signaling R-HSA-9020591 1.659693e-02 1.780 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.685692e-02 1.773 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.685692e-02 1.773 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.746992e-02 1.758 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.746992e-02 1.758 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.749503e-02 1.757 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.863134e-02 1.730 0 0
Signaling by WNT R-HSA-195721 1.880965e-02 1.726 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.907920e-02 1.719 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.907920e-02 1.719 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.907920e-02 1.719 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.907920e-02 1.719 0 0
PLC beta mediated events R-HSA-112043 1.931158e-02 1.714 0 0
FLT3 Signaling R-HSA-9607240 1.945138e-02 1.711 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.970027e-02 1.706 0 0
RET signaling R-HSA-8853659 1.970722e-02 1.705 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.995331e-02 1.700 0 0
Signaling by AXIN mutants R-HSA-4839735 1.995331e-02 1.700 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.995331e-02 1.700 0 0
MHC class II antigen presentation R-HSA-2132295 2.006555e-02 1.698 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.009053e-02 1.697 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.020156e-02 1.695 0 0
RNA Polymerase I Transcription R-HSA-73864 2.064460e-02 1.685 0 0
G-protein mediated events R-HSA-112040 2.067182e-02 1.685 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.099760e-02 1.678 0 0
Homology Directed Repair R-HSA-5693538 2.149663e-02 1.668 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.216892e-02 1.654 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.245029e-02 1.649 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.577526e-02 1.589 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.375809e-02 1.624 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.322499e-02 1.634 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.286045e-02 1.641 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.269473e-02 1.644 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.216892e-02 1.654 0 0
Signaling by TGFBR3 R-HSA-9839373 2.182945e-02 1.661 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.298595e-02 1.639 0 0
Ca-dependent events R-HSA-111996 2.587643e-02 1.587 0 0
Base Excision Repair R-HSA-73884 2.466371e-02 1.608 0 0
Diseases of DNA repair R-HSA-9675135 2.182945e-02 1.661 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.587643e-02 1.587 0 0
Depyrimidination R-HSA-73928 2.587643e-02 1.587 0 0
Transmission across Chemical Synapses R-HSA-112315 2.588605e-02 1.587 0 0
Glycolysis R-HSA-70171 2.594697e-02 1.586 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.623029e-02 1.581 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.623029e-02 1.581 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.623029e-02 1.581 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.623029e-02 1.581 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.623029e-02 1.581 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.623029e-02 1.581 0 0
Signaling by LTK R-HSA-9842663 2.623029e-02 1.581 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.664975e-02 1.574 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.664975e-02 1.574 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.677737e-02 1.572 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.677737e-02 1.572 0 0
Signaling by MAPK mutants R-HSA-9652817 2.677737e-02 1.572 0 0
Neurodegenerative Diseases R-HSA-8863678 2.704765e-02 1.568 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.704765e-02 1.568 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.711216e-02 1.567 0 0
Chromosome Maintenance R-HSA-73886 2.747531e-02 1.561 0 0
ALK mutants bind TKIs R-HSA-9700645 2.778408e-02 1.556 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.834225e-02 1.548 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.919092e-02 1.535 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.919092e-02 1.535 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.949506e-02 1.530 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.949506e-02 1.530 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.974131e-02 1.527 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.996176e-02 1.523 0 0
Metabolism of RNA R-HSA-8953854 3.050529e-02 1.516 0 0
HCMV Early Events R-HSA-9609690 3.066543e-02 1.513 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.066543e-02 1.513 0 0
RAF activation R-HSA-5673000 3.161822e-02 1.500 0 0
Gap junction assembly R-HSA-190861 3.161822e-02 1.500 0 0
Gap junction trafficking and regulation R-HSA-157858 3.216938e-02 1.493 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.219236e-02 1.492 0 0
Activation of BH3-only proteins R-HSA-114452 3.219236e-02 1.492 0 0
TGFBR3 expression R-HSA-9839394 3.227087e-02 1.491 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.227087e-02 1.491 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.228776e-02 1.491 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.228776e-02 1.491 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.228776e-02 1.491 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.228776e-02 1.491 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.228776e-02 1.491 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.228776e-02 1.491 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.253183e-02 1.488 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.369550e-02 1.472 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.369550e-02 1.472 0 0
Cell junction organization R-HSA-446728 3.412981e-02 1.467 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.430710e-02 1.465 0 0
Autophagy R-HSA-9612973 3.437942e-02 1.464 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.522144e-02 1.453 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.856152e-02 1.414 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.856152e-02 1.414 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.675235e-02 1.435 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.675235e-02 1.435 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.757265e-02 1.425 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.757265e-02 1.425 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.970402e-02 1.401 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.856152e-02 1.414 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.686947e-02 1.433 0 0
Signaling by Hippo R-HSA-2028269 3.675235e-02 1.435 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.217222e-02 1.375 0 0
Macroautophagy R-HSA-1632852 3.989542e-02 1.399 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.712650e-02 1.430 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.017058e-02 1.396 0 0
Signaling by PTK6 R-HSA-8848021 4.464400e-02 1.350 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.464400e-02 1.350 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.801847e-02 1.420 0 0
Hemostasis R-HSA-109582 3.997641e-02 1.398 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.712650e-02 1.430 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.472186e-02 1.349 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.472815e-02 1.349 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.472815e-02 1.349 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.558683e-02 1.341 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.558683e-02 1.341 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.558683e-02 1.341 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.567351e-02 1.340 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.606399e-02 1.337 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.720897e-02 1.326 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.793369e-02 1.319 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.793369e-02 1.319 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.818430e-02 1.317 0 0
Signaling by APC mutants R-HSA-4839744 4.818430e-02 1.317 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.818430e-02 1.317 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.818430e-02 1.317 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.818430e-02 1.317 0 0
Signaling by Hedgehog R-HSA-5358351 4.907025e-02 1.309 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.012893e-02 1.300 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.213161e-02 1.283 0 0
DCC mediated attractive signaling R-HSA-418885 5.242565e-02 1.280 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.242565e-02 1.280 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.242565e-02 1.280 0 0
SOS-mediated signalling R-HSA-112412 5.287286e-02 1.277 0 0
Metabolism of non-coding RNA R-HSA-194441 5.287853e-02 1.277 0 0
snRNP Assembly R-HSA-191859 5.287853e-02 1.277 0 0
Interleukin-12 family signaling R-HSA-447115 5.312358e-02 1.275 0 0
The NLRP3 inflammasome R-HSA-844456 5.372347e-02 1.270 0 0
Telomere Maintenance R-HSA-157579 5.380617e-02 1.269 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.387506e-02 1.269 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.395636e-02 1.268 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.561935e-02 1.255 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.662375e-02 1.247 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.734659e-02 1.241 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.734659e-02 1.241 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.935552e-02 1.227 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.004432e-02 1.222 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.098810e-02 1.215 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.098810e-02 1.215 0 0
G1/S Transition R-HSA-69206 6.119544e-02 1.213 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.152869e-02 1.211 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.152869e-02 1.211 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.376154e-02 1.195 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.378095e-02 1.195 0 0
Nephrin family interactions R-HSA-373753 6.378095e-02 1.195 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.639234e-02 1.178 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 6.639234e-02 1.178 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.639234e-02 1.178 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 6.639234e-02 1.178 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 6.639234e-02 1.178 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.639234e-02 1.178 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 6.639234e-02 1.178 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 6.639234e-02 1.178 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 6.639234e-02 1.178 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 6.639234e-02 1.178 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 7.572731e-02 1.121 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.572731e-02 1.121 0 0
Type I hemidesmosome assembly R-HSA-446107 6.968363e-02 1.157 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.968363e-02 1.157 0 0
Activation of RAS in B cells R-HSA-1169092 6.968363e-02 1.157 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.553397e-02 1.122 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.553397e-02 1.122 0 0
Leading Strand Synthesis R-HSA-69109 7.553397e-02 1.122 0 0
Polymerase switching R-HSA-69091 7.553397e-02 1.122 0 0
Disorders of Developmental Biology R-HSA-9675151 7.642690e-02 1.117 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.490631e-02 1.125 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.490631e-02 1.125 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.882231e-02 1.162 0 0
Activation of the pre-replicative complex R-HSA-68962 6.882231e-02 1.162 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.882231e-02 1.162 0 0
Trafficking of AMPA receptors R-HSA-399719 7.836154e-02 1.106 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.373694e-02 1.132 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.285539e-02 1.138 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.618896e-02 1.065 0 0
RUNX2 regulates bone development R-HSA-8941326 8.292785e-02 1.081 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.503860e-02 1.070 0 0
Signaling by EGFR R-HSA-177929 6.923660e-02 1.160 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.373694e-02 1.132 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.738627e-02 1.111 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.221865e-02 1.141 0 0
Neurexins and neuroligins R-HSA-6794361 8.216995e-02 1.085 0 0
MAP2K and MAPK activation R-HSA-5674135 8.626431e-02 1.064 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.572731e-02 1.121 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.409198e-02 1.075 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.553397e-02 1.122 0 0
Signalling to ERKs R-HSA-187687 7.373694e-02 1.132 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.932910e-02 1.101 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.662076e-02 1.116 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.463657e-02 1.072 0 0
Cardiac conduction R-HSA-5576891 6.470852e-02 1.189 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.557861e-02 1.183 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.968363e-02 1.157 0 0
Signaling by NOTCH R-HSA-157118 8.591216e-02 1.066 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.946159e-02 1.158 0 0
Signaling by NTRKs R-HSA-166520 6.642837e-02 1.178 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.017259e-02 1.096 0 0
Gap junction trafficking R-HSA-190828 6.479156e-02 1.188 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.214851e-02 1.142 0 0
Interleukin-37 signaling R-HSA-9008059 6.882231e-02 1.162 0 0
Glucose metabolism R-HSA-70326 7.587924e-02 1.120 0 0
Influenza Infection R-HSA-168255 6.901861e-02 1.161 0 0
Interferon Signaling R-HSA-913531 8.635661e-02 1.064 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.709983e-02 1.060 0 0
DNA Replication R-HSA-69306 8.827965e-02 1.054 0 0
DNA strand elongation R-HSA-69190 8.866589e-02 1.052 0 0
Signaling by WNT in cancer R-HSA-4791275 8.866589e-02 1.052 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.889895e-02 1.051 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.889895e-02 1.051 0 0
Unwinding of DNA R-HSA-176974 8.889895e-02 1.051 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.041019e-02 1.044 0 0
Specification of primordial germ cells R-HSA-9827857 9.041019e-02 1.044 0 0
Peptide chain elongation R-HSA-156902 9.150887e-02 1.039 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.178581e-02 1.037 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 9.178581e-02 1.037 0 0
Frs2-mediated activation R-HSA-170968 9.178581e-02 1.037 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.178581e-02 1.037 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.178581e-02 1.037 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.178581e-02 1.037 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.239453e-02 1.034 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.278765e-02 1.033 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.454149e-02 1.024 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.569294e-02 1.019 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.569294e-02 1.019 0 0
Intraflagellar transport R-HSA-5620924 9.767694e-02 1.010 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.775242e-02 1.010 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.967560e-02 1.001 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.973351e-02 1.001 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.973351e-02 1.001 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.973351e-02 1.001 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.990754e-02 1.000 0 0
mTORC1-mediated signalling R-HSA-166208 1.003503e-01 0.998 0 0
Adherens junctions interactions R-HSA-418990 1.019808e-01 0.991 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.024409e-01 0.990 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.024409e-01 0.990 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.024409e-01 0.990 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.024409e-01 0.990 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.024409e-01 0.990 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.038581e-01 0.984 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.056823e-01 0.976 0 0
Polo-like kinase mediated events R-HSA-156711 1.056823e-01 0.976 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.056823e-01 0.976 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.056823e-01 0.976 0 0
Signaling by FGFR4 R-HSA-5654743 1.057142e-01 0.976 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.076021e-01 0.968 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.076744e-01 0.968 0 0
Regulation of TP53 Expression R-HSA-6804754 1.079899e-01 0.967 0 0
Diseases of cellular response to stress R-HSA-9675132 1.079899e-01 0.967 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.079899e-01 0.967 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.079899e-01 0.967 0 0
Potassium transport channels R-HSA-1296067 1.079899e-01 0.967 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.080693e-01 0.966 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.095008e-01 0.961 0 0
Regulation of KIT signaling R-HSA-1433559 1.096786e-01 0.960 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.300288e-01 0.886 0 0
KIT mutants bind TKIs R-HSA-9669921 1.300288e-01 0.886 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.300288e-01 0.886 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.300288e-01 0.886 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.300288e-01 0.886 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.300288e-01 0.886 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.300288e-01 0.886 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.300288e-01 0.886 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.300288e-01 0.886 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.300288e-01 0.886 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.300288e-01 0.886 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.300288e-01 0.886 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.300288e-01 0.886 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.300288e-01 0.886 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.300288e-01 0.886 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.300288e-01 0.886 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.545570e-01 0.811 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.545570e-01 0.811 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.545570e-01 0.811 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.545570e-01 0.811 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.545570e-01 0.811 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.322961e-01 0.878 0 0
CREB phosphorylation R-HSA-199920 1.322961e-01 0.878 0 0
PI3K/AKT activation R-HSA-198203 1.103690e-01 0.957 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.103690e-01 0.957 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.103690e-01 0.957 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.647456e-01 0.783 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.647456e-01 0.783 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.647456e-01 0.783 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.647456e-01 0.783 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.647456e-01 0.783 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.647456e-01 0.783 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 1.647456e-01 0.783 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.647456e-01 0.783 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.339011e-01 0.873 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.339011e-01 0.873 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.592712e-01 0.798 0 0
Erythropoietin activates RAS R-HSA-9027284 1.291221e-01 0.889 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.291221e-01 0.889 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.291221e-01 0.889 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.500049e-01 0.824 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.500049e-01 0.824 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.299224e-01 0.886 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.299224e-01 0.886 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.299224e-01 0.886 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.587077e-01 0.799 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.204348e-01 0.919 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.204348e-01 0.919 0 0
Late endosomal microautophagy R-HSA-9615710 1.204348e-01 0.919 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.346538e-01 0.871 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.633248e-01 0.787 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.392716e-01 0.856 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.515851e-01 0.819 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.127763e-01 0.948 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.534859e-01 0.814 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.543797e-01 0.811 0 0
Neutrophil degranulation R-HSA-6798695 1.619858e-01 0.791 0 0
Protein folding R-HSA-391251 1.285032e-01 0.891 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.633248e-01 0.787 0 0
Cyclin D associated events in G1 R-HSA-69231 1.163235e-01 0.934 0 0
G1 Phase R-HSA-69236 1.163235e-01 0.934 0 0
IGF1R signaling cascade R-HSA-2428924 1.371648e-01 0.863 0 0
Specification of the neural plate border R-HSA-9834899 1.221980e-01 0.913 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.388201e-01 0.858 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.176676e-01 0.929 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.633248e-01 0.787 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.322961e-01 0.878 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.587077e-01 0.799 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.457084e-01 0.837 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.357607e-01 0.867 0 0
Adipogenesis R-HSA-9843745 1.336215e-01 0.874 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.476151e-01 0.831 0 0
Signaling by FGFR3 R-HSA-5654741 1.275130e-01 0.894 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.103690e-01 0.957 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.461692e-01 0.835 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.374131e-01 0.862 0 0
UCH proteinases R-HSA-5689603 1.341454e-01 0.872 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.103690e-01 0.957 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.647456e-01 0.783 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.221980e-01 0.913 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.592712e-01 0.798 0 0
Sodium/Calcium exchangers R-HSA-425561 1.592712e-01 0.798 0 0
Prolonged ERK activation events R-HSA-169893 1.500049e-01 0.824 0 0
Opioid Signalling R-HSA-111885 1.320637e-01 0.879 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.400180e-01 0.854 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.400180e-01 0.854 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.263431e-01 0.898 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.263431e-01 0.898 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.152718e-01 0.938 0 0
GPER1 signaling R-HSA-9634597 1.644362e-01 0.784 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.201764e-01 0.920 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.605930e-01 0.794 0 0
Signaling by TGFB family members R-HSA-9006936 1.262590e-01 0.899 0 0
Integration of energy metabolism R-HSA-163685 1.308483e-01 0.883 0 0
HCMV Infection R-HSA-9609646 1.297825e-01 0.887 0 0
DNA Repair R-HSA-73894 1.181779e-01 0.927 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.647456e-01 0.783 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.275130e-01 0.894 0 0
Nef and signal transduction R-HSA-164944 1.322961e-01 0.878 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.291221e-01 0.889 0 0
Eukaryotic Translation Termination R-HSA-72764 1.635995e-01 0.786 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.636919e-01 0.786 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.592712e-01 0.798 0 0
Downstream signal transduction R-HSA-186763 1.496818e-01 0.825 0 0
Adaptive Immune System R-HSA-1280218 1.202694e-01 0.920 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.176676e-01 0.929 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.275130e-01 0.894 0 0
Signaling by ALK R-HSA-201556 1.145033e-01 0.941 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.535634e-01 0.814 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.263431e-01 0.898 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.388201e-01 0.858 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.591896e-01 0.798 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.291221e-01 0.889 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.654887e-01 0.781 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.660673e-01 0.780 0 0
Cell-cell junction organization R-HSA-421270 1.715927e-01 0.766 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.721985e-01 0.764 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.721985e-01 0.764 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.721985e-01 0.764 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.721985e-01 0.764 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.731076e-01 0.762 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.778047e-01 0.750 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.778047e-01 0.750 0 0
Signaling by FGFR in disease R-HSA-1226099 1.778370e-01 0.750 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.785455e-01 0.748 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.785455e-01 0.748 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.785455e-01 0.748 0 0
Signaling by SCF-KIT R-HSA-1433557 1.798732e-01 0.745 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.813307e-01 0.742 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.813307e-01 0.742 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.813307e-01 0.742 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.814174e-01 0.741 0 0
G-protein beta:gamma signalling R-HSA-397795 1.820100e-01 0.740 0 0
Cardiogenesis R-HSA-9733709 1.820100e-01 0.740 0 0
Amyloid fiber formation R-HSA-977225 1.851330e-01 0.733 0 0
Disorders of Nervous System Development R-HSA-9697154 1.862347e-01 0.730 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.862347e-01 0.730 0 0
Pervasive developmental disorders R-HSA-9005895 1.862347e-01 0.730 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.862347e-01 0.730 0 0
Repression of WNT target genes R-HSA-4641265 1.862347e-01 0.730 0 0
Signaling by FGFR1 R-HSA-5654736 1.883913e-01 0.725 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.955615e-01 0.709 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.972768e-01 0.705 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.976690e-01 0.704 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.992192e-01 0.701 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.992375e-01 0.701 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.992375e-01 0.701 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.992375e-01 0.701 0 0
Notch-HLH transcription pathway R-HSA-350054 1.993181e-01 0.700 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.993181e-01 0.700 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.993181e-01 0.700 0 0
HIV elongation arrest and recovery R-HSA-167287 2.001218e-01 0.699 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.001218e-01 0.699 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.001218e-01 0.699 0 0
Inflammasomes R-HSA-622312 2.001218e-01 0.699 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.040991e-01 0.690 0 0
Regulation of gap junction activity R-HSA-191650 2.040991e-01 0.690 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.040991e-01 0.690 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.040991e-01 0.690 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.040991e-01 0.690 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.040991e-01 0.690 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.040991e-01 0.690 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.040991e-01 0.690 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.040991e-01 0.690 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.040991e-01 0.690 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.040991e-01 0.690 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.040991e-01 0.690 0 0
Dopamine receptors R-HSA-390651 2.040991e-01 0.690 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.040991e-01 0.690 0 0
Developmental Cell Lineages R-HSA-9734767 2.045620e-01 0.689 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.431566e-01 0.614 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.431566e-01 0.614 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.431566e-01 0.614 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.431566e-01 0.614 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.431566e-01 0.614 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.431566e-01 0.614 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.431566e-01 0.614 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.431566e-01 0.614 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.431566e-01 0.614 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.415794e-01 0.467 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.415794e-01 0.467 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.415794e-01 0.467 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.415794e-01 0.467 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.415794e-01 0.467 0 0
Mitochondrial transcription initiation R-HSA-163282 3.415794e-01 0.467 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.415794e-01 0.467 0 0
Intestinal infectious diseases R-HSA-8942233 3.415794e-01 0.467 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.415794e-01 0.467 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.415794e-01 0.467 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.415794e-01 0.467 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.415794e-01 0.467 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.415794e-01 0.467 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.415794e-01 0.467 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.415794e-01 0.467 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.415794e-01 0.467 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.415794e-01 0.467 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.415794e-01 0.467 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.415794e-01 0.467 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.415794e-01 0.467 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 3.415794e-01 0.467 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.415794e-01 0.467 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.415794e-01 0.467 0 0
IRS activation R-HSA-74713 2.550562e-01 0.593 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.550562e-01 0.593 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.550562e-01 0.593 0 0
G2 Phase R-HSA-68911 2.550562e-01 0.593 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.550562e-01 0.593 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.550562e-01 0.593 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.550562e-01 0.593 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.352382e-01 0.628 0 0
WNT mediated activation of DVL R-HSA-201688 2.352382e-01 0.628 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.062233e-01 0.514 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.062233e-01 0.514 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.272079e-01 0.369 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.272079e-01 0.369 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.272079e-01 0.369 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.272079e-01 0.369 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.272079e-01 0.369 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.272079e-01 0.369 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.272079e-01 0.369 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.272079e-01 0.369 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.272079e-01 0.369 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.272079e-01 0.369 0 0
Defective F8 sulfation at Y1699 R-HSA-9674519 4.272079e-01 0.369 0 0
Formation of axial mesoderm R-HSA-9796292 2.145350e-01 0.669 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.722470e-01 0.565 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.722470e-01 0.565 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.439125e-01 0.613 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.566846e-01 0.448 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.566846e-01 0.448 0 0
PKA activation in glucagon signalling R-HSA-164378 2.199432e-01 0.658 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.098063e-01 0.509 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.741100e-01 0.562 0 0
Translesion synthesis by REV1 R-HSA-110312 2.741100e-01 0.562 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.741100e-01 0.562 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.741100e-01 0.562 0 0
Regulation of signaling by CBL R-HSA-912631 2.451875e-01 0.611 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.451875e-01 0.611 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.451875e-01 0.611 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.451875e-01 0.611 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.451875e-01 0.611 0 0
Signaling by Erythropoietin R-HSA-9006335 2.196277e-01 0.658 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.432649e-01 0.614 0 0
Deadenylation of mRNA R-HSA-429947 2.432649e-01 0.614 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.711360e-01 0.567 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.711360e-01 0.567 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.711360e-01 0.567 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.711360e-01 0.567 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.711360e-01 0.567 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.711360e-01 0.567 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.048789e-01 0.516 0 0
Translesion synthesis by POLI R-HSA-5656121 3.048789e-01 0.516 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.048789e-01 0.516 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.475068e-01 0.459 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.475068e-01 0.459 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.475068e-01 0.459 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.475068e-01 0.459 0 0
CHL1 interactions R-HSA-447041 4.057587e-01 0.392 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.057587e-01 0.392 0 0
Netrin mediated repulsion signals R-HSA-418886 4.057587e-01 0.392 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.057587e-01 0.392 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.057587e-01 0.392 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.662268e-01 0.575 0 0
HIV Transcription Elongation R-HSA-167169 2.137462e-01 0.670 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.137462e-01 0.670 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.137462e-01 0.670 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.354670e-01 0.628 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.354670e-01 0.628 0 0
PERK regulates gene expression R-HSA-381042 2.354670e-01 0.628 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.359833e-01 0.474 0 0
Translesion synthesis by POLK R-HSA-5655862 3.359833e-01 0.474 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.897023e-01 0.538 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.849893e-01 0.415 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.849893e-01 0.415 0 0
G1/S-Specific Transcription R-HSA-69205 2.543907e-01 0.594 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.245170e-01 0.489 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.245170e-01 0.489 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.207757e-01 0.656 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.420332e-01 0.616 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.135820e-01 0.504 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.359631e-01 0.627 0 0
Signaling by KIT in disease R-HSA-9669938 3.516455e-01 0.454 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.516455e-01 0.454 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.516455e-01 0.454 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.219451e-01 0.375 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.219451e-01 0.375 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.219451e-01 0.375 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.251692e-01 0.488 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.596344e-01 0.586 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.929998e-01 0.533 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.788735e-01 0.422 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.788735e-01 0.422 0 0
Dual Incision in GG-NER R-HSA-5696400 3.473162e-01 0.459 0 0
Viral mRNA Translation R-HSA-192823 2.470801e-01 0.607 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.409049e-01 0.467 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.865810e-01 0.413 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.060669e-01 0.391 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.464787e-01 0.460 0 0
EGFR downregulation R-HSA-182971 4.110292e-01 0.386 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.792705e-01 0.421 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.056616e-01 0.392 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.752273e-01 0.426 0 0
Formation of definitive endoderm R-HSA-9823730 2.711360e-01 0.567 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.199432e-01 0.658 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.683216e-01 0.434 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.263498e-01 0.486 0 0
Lagging Strand Synthesis R-HSA-69186 2.976307e-01 0.526 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.475068e-01 0.459 0 0
Signalling to RAS R-HSA-167044 2.976307e-01 0.526 0 0
Signaling by FGFR2 R-HSA-5654738 2.513164e-01 0.600 0 0
G0 and Early G1 R-HSA-1538133 2.816705e-01 0.550 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.816705e-01 0.550 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.621249e-01 0.441 0 0
IRS-mediated signalling R-HSA-112399 4.197076e-01 0.377 0 0
Insulin receptor signalling cascade R-HSA-74751 4.205886e-01 0.376 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.962926e-01 0.528 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.045445e-01 0.393 0 0
Signal attenuation R-HSA-74749 2.722470e-01 0.565 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.359833e-01 0.474 0 0
Myogenesis R-HSA-525793 2.897023e-01 0.538 0 0
Signal amplification R-HSA-392518 3.473162e-01 0.459 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.359833e-01 0.474 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.062233e-01 0.514 0 0
Regulation of CDH11 function R-HSA-9762292 2.722470e-01 0.565 0 0
p38MAPK events R-HSA-171007 2.741100e-01 0.562 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.057587e-01 0.392 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.170569e-01 0.663 0 0
Cellular response to starvation R-HSA-9711097 2.652748e-01 0.576 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.756757e-01 0.560 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.135820e-01 0.504 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.446629e-01 0.611 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.446629e-01 0.611 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.446629e-01 0.611 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.446629e-01 0.611 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.550562e-01 0.593 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.550562e-01 0.593 0 0
cGMP effects R-HSA-418457 2.439125e-01 0.613 0 0
PKA activation R-HSA-163615 2.199432e-01 0.658 0 0
Signaling by NODAL R-HSA-1181150 2.711360e-01 0.567 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.849893e-01 0.415 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.849893e-01 0.415 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.513164e-01 0.600 0 0
Potassium Channels R-HSA-1296071 2.424838e-01 0.615 0 0
PTEN Regulation R-HSA-6807070 4.205936e-01 0.376 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.410700e-01 0.618 0 0
Interleukin-2 signaling R-HSA-9020558 3.098063e-01 0.509 0 0
Nuclear RNA decay R-HSA-9930044 3.032604e-01 0.518 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.897023e-01 0.538 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.849893e-01 0.415 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.516455e-01 0.454 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.048789e-01 0.516 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.550562e-01 0.593 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.352382e-01 0.628 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.272079e-01 0.369 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.439125e-01 0.613 0 0
Abacavir transmembrane transport R-HSA-2161517 3.566846e-01 0.448 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.057587e-01 0.392 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.849893e-01 0.415 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.219451e-01 0.375 0 0
Membrane Trafficking R-HSA-199991 2.175332e-01 0.662 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.377580e-01 0.471 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.621249e-01 0.441 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.621249e-01 0.441 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.865810e-01 0.413 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.195903e-01 0.658 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.184798e-01 0.378 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.446629e-01 0.611 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.219451e-01 0.375 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.904683e-01 0.537 0 0
Co-inhibition by PD-1 R-HSA-389948 4.168370e-01 0.380 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.135820e-01 0.504 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.550562e-01 0.593 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.352382e-01 0.628 0 0
MET activates RAS signaling R-HSA-8851805 3.849893e-01 0.415 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.085391e-01 0.389 0 0
Hedgehog 'on' state R-HSA-5632684 4.212086e-01 0.376 0 0
DARPP-32 events R-HSA-180024 3.621249e-01 0.441 0 0
Regulation of insulin secretion R-HSA-422356 2.662696e-01 0.575 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.722470e-01 0.565 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.341566e-01 0.476 0 0
Signaling by NOTCH1 R-HSA-1980143 2.869232e-01 0.542 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.621249e-01 0.441 0 0
mRNA Editing R-HSA-75072 2.352382e-01 0.628 0 0
MTOR signalling R-HSA-165159 2.660884e-01 0.575 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.532520e-01 0.452 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.205886e-01 0.376 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.532520e-01 0.452 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.532520e-01 0.452 0 0
HIV Life Cycle R-HSA-162587 3.229520e-01 0.491 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.431566e-01 0.614 0 0
Inhibition of PKR R-HSA-169131 2.431566e-01 0.614 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.550562e-01 0.593 0 0
ARMS-mediated activation R-HSA-170984 2.352382e-01 0.628 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.352382e-01 0.628 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.062233e-01 0.514 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.062233e-01 0.514 0 0
Formation of the Editosome R-HSA-75094 3.062233e-01 0.514 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.272079e-01 0.369 0 0
C6 deamination of adenosine R-HSA-75102 4.272079e-01 0.369 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.272079e-01 0.369 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.272079e-01 0.369 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.272079e-01 0.369 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.199432e-01 0.658 0 0
Regulation of PTEN localization R-HSA-8948747 4.057587e-01 0.392 0 0
Regulation of IFNG signaling R-HSA-877312 3.849893e-01 0.415 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.737670e-01 0.563 0 0
Smooth Muscle Contraction R-HSA-445355 2.359631e-01 0.627 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 4.219451e-01 0.375 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.788735e-01 0.422 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.836816e-01 0.547 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.683216e-01 0.434 0 0
Signaling by NOTCH4 R-HSA-9013694 3.580590e-01 0.446 0 0
rRNA processing R-HSA-72312 3.959692e-01 0.402 0 0
Host Interactions of HIV factors R-HSA-162909 3.718651e-01 0.430 0 0
Signaling by ERBB4 R-HSA-1236394 3.580590e-01 0.446 0 0
HCMV Late Events R-HSA-9610379 3.229520e-01 0.491 0 0
Ion transport by P-type ATPases R-HSA-936837 3.062713e-01 0.514 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.439125e-01 0.613 0 0
Sensory processing of sound R-HSA-9659379 2.383133e-01 0.623 0 0
PECAM1 interactions R-HSA-210990 3.098063e-01 0.509 0 0
tRNA processing in the nucleus R-HSA-6784531 2.749127e-01 0.561 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.218884e-01 0.375 0 0
Platelet homeostasis R-HSA-418346 2.942884e-01 0.531 0 0
Immune System R-HSA-168256 2.425835e-01 0.615 0 0
Stimuli-sensing channels R-HSA-2672351 4.084451e-01 0.389 1 1
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.550562e-01 0.593 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.062233e-01 0.514 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.062233e-01 0.514 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.475068e-01 0.459 0 0
OAS antiviral response R-HSA-8983711 3.849893e-01 0.415 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.962926e-01 0.528 0 0
Heme signaling R-HSA-9707616 3.856921e-01 0.414 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.352382e-01 0.628 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.062233e-01 0.514 0 0
DSCAM interactions R-HSA-376172 4.272079e-01 0.369 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.722470e-01 0.565 0 0
Formation of the anterior neural plate R-HSA-9823739 2.741100e-01 0.562 0 0
Activation of SMO R-HSA-5635838 3.048789e-01 0.516 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.170569e-01 0.663 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.245170e-01 0.489 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.515319e-01 0.599 0 0
Maturation of nucleoprotein R-HSA-9683610 4.219451e-01 0.375 0 0
Syndecan interactions R-HSA-3000170 3.788735e-01 0.422 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.959945e-01 0.402 0 0
FLT3 signaling in disease R-HSA-9682385 3.920091e-01 0.407 0 0
Signal regulatory protein family interactions R-HSA-391160 2.439125e-01 0.613 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.219451e-01 0.375 0 0
Tie2 Signaling R-HSA-210993 2.199432e-01 0.658 0 0
Selenocysteine synthesis R-HSA-2408557 2.247119e-01 0.648 0 0
NrCAM interactions R-HSA-447038 2.550562e-01 0.593 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.586731e-01 0.587 0 0
Growth hormone receptor signaling R-HSA-982772 3.788735e-01 0.422 0 0
Regulation of beta-cell development R-HSA-186712 3.339142e-01 0.476 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.763563e-01 0.559 0 0
HDL assembly R-HSA-8963896 2.439125e-01 0.613 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.205936e-01 0.376 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.451875e-01 0.611 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.060669e-01 0.391 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.272079e-01 0.369 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.057587e-01 0.392 0 0
Nephron development R-HSA-9831926 3.983337e-01 0.400 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.219451e-01 0.375 0 0
Signaling by Leptin R-HSA-2586552 2.722470e-01 0.565 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.219451e-01 0.375 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.291934e-01 0.367 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.331009e-01 0.363 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.331009e-01 0.363 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.331009e-01 0.363 0 0
Interleukin-7 signaling R-HSA-1266695 4.331009e-01 0.363 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.353778e-01 0.361 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.353778e-01 0.361 0 0
IRE1alpha activates chaperones R-HSA-381070 4.368321e-01 0.360 0 0
Ion channel transport R-HSA-983712 4.487827e-01 0.348 1 0
Signaling by FGFR R-HSA-190236 4.506816e-01 0.346 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.525882e-01 0.344 0 0
RSK activation R-HSA-444257 4.529532e-01 0.344 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.529532e-01 0.344 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.529532e-01 0.344 0 0
Adrenoceptors R-HSA-390696 4.529532e-01 0.344 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.529532e-01 0.344 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.529532e-01 0.344 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.529532e-01 0.344 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.529532e-01 0.344 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.529532e-01 0.344 0 0
Co-stimulation by ICOS R-HSA-9927354 4.529532e-01 0.344 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.529532e-01 0.344 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.529532e-01 0.344 0 0
Sodium/Proton exchangers R-HSA-425986 4.529532e-01 0.344 0 0
Signaling by MET R-HSA-6806834 4.535485e-01 0.343 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.545086e-01 0.342 0 0
Orc1 removal from chromatin R-HSA-68949 4.573104e-01 0.340 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.573104e-01 0.340 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.581140e-01 0.339 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.581140e-01 0.339 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.581140e-01 0.339 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.581672e-01 0.339 0 0
Stabilization of p53 R-HSA-69541 4.589332e-01 0.338 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.595407e-01 0.338 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.595407e-01 0.338 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.595407e-01 0.338 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.596178e-01 0.338 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.596178e-01 0.338 0 0
Rab regulation of trafficking R-HSA-9007101 4.609636e-01 0.336 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.680090e-01 0.330 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.694527e-01 0.328 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.710870e-01 0.327 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.786666e-01 0.320 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.786666e-01 0.320 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.809376e-01 0.318 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.809376e-01 0.318 0 0
Interleukin-2 family signaling R-HSA-451927 4.809376e-01 0.318 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.834386e-01 0.316 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.834386e-01 0.316 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.862425e-01 0.313 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.862425e-01 0.313 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.879589e-01 0.312 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.894630e-01 0.310 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.894630e-01 0.310 0 0
Synthesis of DNA R-HSA-69239 4.911645e-01 0.309 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.932815e-01 0.307 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.932815e-01 0.307 0 0
Signaling by Activin R-HSA-1502540 4.932815e-01 0.307 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.932815e-01 0.307 0 0
p75NTR signals via NF-kB R-HSA-193639 4.932815e-01 0.307 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.932815e-01 0.307 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.932815e-01 0.307 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.979272e-01 0.303 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.979272e-01 0.303 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.979272e-01 0.303 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.979272e-01 0.303 0 0
Calcineurin activates NFAT R-HSA-2025928 4.979272e-01 0.303 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.979272e-01 0.303 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.979272e-01 0.303 0 0
Interleukin-1 processing R-HSA-448706 4.979272e-01 0.303 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.979272e-01 0.303 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.979272e-01 0.303 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.979272e-01 0.303 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.017046e-01 0.300 0 0
Axonal growth stimulation R-HSA-209563 5.017046e-01 0.300 0 0
Classical Kir channels R-HSA-1296053 5.017046e-01 0.300 0 0
Invadopodia formation R-HSA-8941237 5.017046e-01 0.300 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.017046e-01 0.300 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.017046e-01 0.300 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.017046e-01 0.300 0 0
Histamine receptors R-HSA-390650 5.017046e-01 0.300 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.017046e-01 0.300 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.026885e-01 0.299 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.069984e-01 0.295 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.069984e-01 0.295 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.069984e-01 0.295 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.069984e-01 0.295 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.121528e-01 0.291 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.121528e-01 0.291 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.121528e-01 0.291 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.241315e-01 0.281 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.241315e-01 0.281 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.241315e-01 0.281 0 0
SARS-CoV Infections R-HSA-9679506 5.261682e-01 0.279 0 0
Phosphorylation of the APC/C R-HSA-176412 5.272753e-01 0.278 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.272753e-01 0.278 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.272753e-01 0.278 0 0
Negative regulation of FLT3 R-HSA-9706369 5.272753e-01 0.278 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.375094e-01 0.270 0 0
Degradation of CDH1 R-HSA-9766229 5.388078e-01 0.269 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.404600e-01 0.267 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.404600e-01 0.267 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.404600e-01 0.267 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.469386e-01 0.262 0 0
FGFR2 alternative splicing R-HSA-6803529 5.469386e-01 0.262 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.469386e-01 0.262 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.469386e-01 0.262 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.469386e-01 0.262 0 0
HIV Infection R-HSA-162906 5.509863e-01 0.259 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.528460e-01 0.257 0 0
PI3K Cascade R-HSA-109704 5.582617e-01 0.253 0 0
Inositol phosphate metabolism R-HSA-1483249 5.586963e-01 0.253 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.599618e-01 0.252 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.599618e-01 0.252 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.599618e-01 0.252 0 0
Passive transport by Aquaporins R-HSA-432047 5.599618e-01 0.252 0 0
DAP12 signaling R-HSA-2424491 5.622406e-01 0.250 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.622406e-01 0.250 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.658995e-01 0.247 0 0
HCN channels R-HSA-1296061 5.665161e-01 0.247 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.665161e-01 0.247 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.665161e-01 0.247 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.665161e-01 0.247 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.665161e-01 0.247 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.665161e-01 0.247 0 0
Alanine metabolism R-HSA-8964540 5.665161e-01 0.247 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.665161e-01 0.247 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.665161e-01 0.247 0 0
Ca2+ pathway R-HSA-4086398 5.737521e-01 0.241 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.743769e-01 0.241 0 0
Ribosome-associated quality control R-HSA-9948299 5.799942e-01 0.237 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.803001e-01 0.236 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.803001e-01 0.236 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.804259e-01 0.236 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.804259e-01 0.236 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.804259e-01 0.236 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.804259e-01 0.236 0 0
Formation of the posterior neural plate R-HSA-9832991 5.804259e-01 0.236 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.804259e-01 0.236 0 0
Bicarbonate transporters R-HSA-425381 5.804259e-01 0.236 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 5.804259e-01 0.236 0 0
Transport of RCbl within the body R-HSA-9758890 5.804259e-01 0.236 0 0
LGI-ADAM interactions R-HSA-5682910 5.804259e-01 0.236 0 0
Prostanoid ligand receptors R-HSA-391908 5.804259e-01 0.236 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.862850e-01 0.232 0 0
Extension of Telomeres R-HSA-180786 5.876298e-01 0.231 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.912413e-01 0.228 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.912413e-01 0.228 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.912413e-01 0.228 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.912413e-01 0.228 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.912413e-01 0.228 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.912413e-01 0.228 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.912413e-01 0.228 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.912413e-01 0.228 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.943312e-01 0.226 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.959083e-01 0.225 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.960623e-01 0.225 0 0
MET promotes cell motility R-HSA-8875878 5.966370e-01 0.224 0 0
Platelet degranulation R-HSA-114608 6.004317e-01 0.222 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.008499e-01 0.221 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.008499e-01 0.221 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.008499e-01 0.221 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.028910e-01 0.220 0 0
RAB geranylgeranylation R-HSA-8873719 6.050780e-01 0.218 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.059014e-01 0.218 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.059014e-01 0.218 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.059014e-01 0.218 0 0
Transcription of the HIV genome R-HSA-167172 6.133765e-01 0.212 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.143487e-01 0.212 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.158661e-01 0.211 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.174678e-01 0.209 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.174678e-01 0.209 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.177731e-01 0.209 0 0
ERKs are inactivated R-HSA-202670 6.177731e-01 0.209 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.177731e-01 0.209 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.177731e-01 0.209 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.177731e-01 0.209 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.210449e-01 0.207 0 0
GAB1 signalosome R-HSA-180292 6.210449e-01 0.207 0 0
Apoptotic factor-mediated response R-HSA-111471 6.210449e-01 0.207 0 0
Mismatch Repair R-HSA-5358508 6.210449e-01 0.207 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.210449e-01 0.207 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.210449e-01 0.207 0 0
Platelet sensitization by LDL R-HSA-432142 6.210449e-01 0.207 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.210449e-01 0.207 0 0
Aquaporin-mediated transport R-HSA-445717 6.221523e-01 0.206 0 0
MAP kinase activation R-HSA-450294 6.221523e-01 0.206 0 0
Activation of AMPA receptors R-HSA-399710 6.229011e-01 0.206 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.229011e-01 0.206 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.229011e-01 0.206 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.229011e-01 0.206 0 0
Activation of AKT2 R-HSA-165158 6.229011e-01 0.206 0 0
PTK6 Down-Regulation R-HSA-8849472 6.229011e-01 0.206 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.229011e-01 0.206 0 0
Reelin signalling pathway R-HSA-8866376 6.229011e-01 0.206 0 0
Suppression of autophagy R-HSA-9636569 6.229011e-01 0.206 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.229011e-01 0.206 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.229011e-01 0.206 0 0
Co-inhibition by BTLA R-HSA-9927353 6.229011e-01 0.206 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.263035e-01 0.203 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.263035e-01 0.203 0 0
Formation of the nephric duct R-HSA-9830364 6.263035e-01 0.203 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.281720e-01 0.202 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.321184e-01 0.199 0 0
Signaling by PDGF R-HSA-186797 6.388320e-01 0.195 0 0
Potential therapeutics for SARS R-HSA-9679191 6.427810e-01 0.192 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.477789e-01 0.189 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.493297e-01 0.188 0 0
Translesion Synthesis by POLH R-HSA-110320 6.493297e-01 0.188 0 0
Maturation of nucleoprotein R-HSA-9694631 6.493297e-01 0.188 0 0
Other interleukin signaling R-HSA-449836 6.493297e-01 0.188 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.493297e-01 0.188 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.506977e-01 0.187 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.506977e-01 0.187 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.506977e-01 0.187 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.525066e-01 0.185 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.525066e-01 0.185 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.525066e-01 0.185 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.525066e-01 0.185 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.525066e-01 0.185 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.525066e-01 0.185 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.525066e-01 0.185 0 0
Estrogen biosynthesis R-HSA-193144 6.525066e-01 0.185 0 0
Cellular response to chemical stress R-HSA-9711123 6.536975e-01 0.185 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.538327e-01 0.185 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.538327e-01 0.185 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.603223e-01 0.180 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.604551e-01 0.180 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.604551e-01 0.180 0 0
NGF-stimulated transcription R-HSA-9031628 6.620317e-01 0.179 0 0
Metal ion SLC transporters R-HSA-425410 6.620317e-01 0.179 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.656922e-01 0.177 0 0
TNF signaling R-HSA-75893 6.664633e-01 0.176 0 0
Circadian clock R-HSA-9909396 6.697324e-01 0.174 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.719546e-01 0.173 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.719546e-01 0.173 0 0
PDE3B signalling R-HSA-165160 6.719546e-01 0.173 0 0
PKB-mediated events R-HSA-109703 6.719546e-01 0.173 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.719546e-01 0.173 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.719546e-01 0.173 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.719546e-01 0.173 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.719546e-01 0.173 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.719546e-01 0.173 0 0
Phosphorylation of Emi1 R-HSA-176417 6.719546e-01 0.173 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.719546e-01 0.173 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.719546e-01 0.173 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.719546e-01 0.173 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.719546e-01 0.173 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.719546e-01 0.173 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.719546e-01 0.173 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.719546e-01 0.173 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.740058e-01 0.171 0 0
Signaling by NOTCH2 R-HSA-1980145 6.747101e-01 0.171 0 0
Mitophagy R-HSA-5205647 6.747101e-01 0.171 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.753968e-01 0.170 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.753968e-01 0.170 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.753968e-01 0.170 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.755190e-01 0.170 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.760757e-01 0.170 0 0
Negative regulation of MET activity R-HSA-6807004 6.760757e-01 0.170 0 0
Protein hydroxylation R-HSA-9629569 6.760757e-01 0.170 0 0
Signal transduction by L1 R-HSA-445144 6.760757e-01 0.170 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.760757e-01 0.170 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.760757e-01 0.170 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.767917e-01 0.170 0 0
DNA Damage Bypass R-HSA-73893 6.796165e-01 0.168 0 0
G alpha (q) signalling events R-HSA-416476 6.811173e-01 0.167 0 0
Regulation of CDH1 Function R-HSA-9764561 6.828587e-01 0.166 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.846744e-01 0.165 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.846744e-01 0.165 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.846744e-01 0.165 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.846744e-01 0.165 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.935557e-01 0.159 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.951342e-01 0.158 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.962129e-01 0.157 0 0
Telomere Extension By Telomerase R-HSA-171319 6.962129e-01 0.157 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.962129e-01 0.157 0 0
Pyroptosis R-HSA-5620971 6.962129e-01 0.157 0 0
Viral Infection Pathways R-HSA-9824446 6.974664e-01 0.156 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.987433e-01 0.156 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.006512e-01 0.154 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.012822e-01 0.154 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.012822e-01 0.154 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.012822e-01 0.154 0 0
ERK/MAPK targets R-HSA-198753 7.012822e-01 0.154 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.012822e-01 0.154 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.012822e-01 0.154 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.012822e-01 0.154 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.045617e-01 0.152 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.117266e-01 0.148 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.132392e-01 0.147 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.138935e-01 0.146 0 0
RNA Polymerase III Transcription R-HSA-74158 7.138935e-01 0.146 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.138935e-01 0.146 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.138935e-01 0.146 0 0
GPVI-mediated activation cascade R-HSA-114604 7.138935e-01 0.146 0 0
Triglyceride catabolism R-HSA-163560 7.138935e-01 0.146 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.143561e-01 0.146 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.143561e-01 0.146 0 0
Removal of the Flap Intermediate R-HSA-69166 7.143561e-01 0.146 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.143561e-01 0.146 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.143561e-01 0.146 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.143561e-01 0.146 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.143561e-01 0.146 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.143561e-01 0.146 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.146297e-01 0.146 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.146297e-01 0.146 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.146297e-01 0.146 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.146297e-01 0.146 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.146297e-01 0.146 0 0
Lactose synthesis R-HSA-5653890 7.146297e-01 0.146 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.146297e-01 0.146 0 0
Signaling by LTK in cancer R-HSA-9842640 7.146297e-01 0.146 0 0
Leukotriene receptors R-HSA-391906 7.146297e-01 0.146 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.146297e-01 0.146 0 0
TCR signaling R-HSA-202403 7.195571e-01 0.143 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.195571e-01 0.143 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.195571e-01 0.143 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.249646e-01 0.140 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.249646e-01 0.140 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.249646e-01 0.140 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.278652e-01 0.138 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.296904e-01 0.137 0 0
Amine ligand-binding receptors R-HSA-375280 7.296904e-01 0.137 0 0
Interferon gamma signaling R-HSA-877300 7.320765e-01 0.135 0 0
Voltage gated Potassium channels R-HSA-1296072 7.321864e-01 0.135 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.373139e-01 0.132 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.373139e-01 0.132 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.373139e-01 0.132 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.381172e-01 0.132 0 0
Interleukin-1 family signaling R-HSA-446652 7.381172e-01 0.132 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.416542e-01 0.130 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.416542e-01 0.130 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.416542e-01 0.130 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.416542e-01 0.130 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.416542e-01 0.130 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.416542e-01 0.130 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.416542e-01 0.130 0 0
Protein methylation R-HSA-8876725 7.416542e-01 0.130 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.439799e-01 0.128 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.471514e-01 0.127 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.471514e-01 0.127 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.471514e-01 0.127 0 0
Ethanol oxidation R-HSA-71384 7.471514e-01 0.127 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.471514e-01 0.127 0 0
LDL clearance R-HSA-8964038 7.471514e-01 0.127 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.496143e-01 0.125 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.517554e-01 0.124 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.517554e-01 0.124 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.517554e-01 0.124 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.517554e-01 0.124 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.517554e-01 0.124 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.517554e-01 0.124 0 0
Disinhibition of SNARE formation R-HSA-114516 7.517554e-01 0.124 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.517554e-01 0.124 0 0
Recycling of eIF2:GDP R-HSA-72731 7.517554e-01 0.124 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.517554e-01 0.124 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.517554e-01 0.124 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.517554e-01 0.124 0 0
VLDL clearance R-HSA-8964046 7.517554e-01 0.124 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.517554e-01 0.124 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.517554e-01 0.124 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.517554e-01 0.124 0 0
Glycoprotein hormones R-HSA-209822 7.517554e-01 0.124 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.517554e-01 0.124 0 0
Maturation of replicase proteins R-HSA-9694301 7.517554e-01 0.124 0 0
Budding and maturation of HIV virion R-HSA-162588 7.562246e-01 0.121 0 0
Interleukin-17 signaling R-HSA-448424 7.564180e-01 0.121 0 0
Signaling by Insulin receptor R-HSA-74752 7.579088e-01 0.120 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.613887e-01 0.118 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.666863e-01 0.115 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.666863e-01 0.115 0 0
Fructose catabolism R-HSA-70350 7.666863e-01 0.115 0 0
Regulation of BACH1 activity R-HSA-9708530 7.666863e-01 0.115 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.666863e-01 0.115 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.666863e-01 0.115 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.678819e-01 0.115 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.685339e-01 0.114 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.712169e-01 0.113 0 0
Signaling by NOTCH3 R-HSA-9012852 7.725138e-01 0.112 0 0
Selenoamino acid metabolism R-HSA-2408522 7.752211e-01 0.111 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.761730e-01 0.110 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.819087e-01 0.107 0 0
Diseases of Immune System R-HSA-5260271 7.819087e-01 0.107 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.819087e-01 0.107 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.840531e-01 0.106 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.840531e-01 0.106 0 0
Formation of annular gap junctions R-HSA-196025 7.840531e-01 0.106 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.840531e-01 0.106 0 0
Interleukin-9 signaling R-HSA-8985947 7.840531e-01 0.106 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.840531e-01 0.106 0 0
Regulation by c-FLIP R-HSA-3371378 7.840531e-01 0.106 0 0
Dimerization of procaspase-8 R-HSA-69416 7.840531e-01 0.106 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.840531e-01 0.106 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.840531e-01 0.106 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.858738e-01 0.105 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.872040e-01 0.104 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.895800e-01 0.103 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.895800e-01 0.103 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.895800e-01 0.103 0 0
Synthesis of PG R-HSA-1483148 7.895800e-01 0.103 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.895800e-01 0.103 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.900407e-01 0.102 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.908595e-01 0.102 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.936339e-01 0.100 0 0
Cellular response to hypoxia R-HSA-1234174 7.951682e-01 0.100 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.968023e-01 0.099 0 0
Maturation of spike protein R-HSA-9694548 7.968023e-01 0.099 0 0
G protein gated Potassium channels R-HSA-1296059 8.051717e-01 0.094 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.051717e-01 0.094 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.051717e-01 0.094 0 0
Tight junction interactions R-HSA-420029 8.051717e-01 0.094 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.051717e-01 0.094 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.051717e-01 0.094 0 0
Glutamate and glutamine metabolism R-HSA-8964539 8.066376e-01 0.093 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.104678e-01 0.091 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.104678e-01 0.091 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.104678e-01 0.091 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.104678e-01 0.091 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.108140e-01 0.091 0 0
Dual incision in TC-NER R-HSA-6782135 8.108140e-01 0.091 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.108842e-01 0.091 0 0
Lipophagy R-HSA-9613354 8.121503e-01 0.090 0 0
Gap junction degradation R-HSA-190873 8.121503e-01 0.090 0 0
CASP8 activity is inhibited R-HSA-5218900 8.121503e-01 0.090 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.121503e-01 0.090 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.121503e-01 0.090 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 8.121503e-01 0.090 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.121503e-01 0.090 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.121503e-01 0.090 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.121503e-01 0.090 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.121503e-01 0.090 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.121503e-01 0.090 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.121503e-01 0.090 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.147588e-01 0.089 0 0
Kidney development R-HSA-9830369 8.179933e-01 0.087 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.214320e-01 0.085 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.214320e-01 0.085 0 0
eNOS activation R-HSA-203615 8.214320e-01 0.085 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.214320e-01 0.085 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.218439e-01 0.085 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.223635e-01 0.085 0 0
Activation of GABAB receptors R-HSA-991365 8.241757e-01 0.084 0 0
GABA B receptor activation R-HSA-977444 8.241757e-01 0.084 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.256832e-01 0.083 0 0
Nucleotide Excision Repair R-HSA-5696398 8.267556e-01 0.083 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.284383e-01 0.082 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.294841e-01 0.081 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.294841e-01 0.081 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.294841e-01 0.081 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.294841e-01 0.081 0 0
GABA receptor activation R-HSA-977443 8.334495e-01 0.079 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.365931e-01 0.077 0 0
2-LTR circle formation R-HSA-164843 8.365931e-01 0.077 0 0
DNA replication initiation R-HSA-68952 8.365931e-01 0.077 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.365931e-01 0.077 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.365931e-01 0.077 0 0
Formation of apoptosome R-HSA-111458 8.365931e-01 0.077 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.365931e-01 0.077 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.365931e-01 0.077 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.365931e-01 0.077 0 0
Metabolism of serotonin R-HSA-380612 8.365931e-01 0.077 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.365931e-01 0.077 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.365931e-01 0.077 0 0
Maturation of spike protein R-HSA-9683686 8.365931e-01 0.077 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.365931e-01 0.077 0 0
Peptide hormone biosynthesis R-HSA-209952 8.365931e-01 0.077 0 0
TBC/RABGAPs R-HSA-8854214 8.367007e-01 0.077 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.372827e-01 0.077 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.372827e-01 0.077 0 0
Insulin processing R-HSA-264876 8.372827e-01 0.077 0 0
Gastrulation R-HSA-9758941 8.397921e-01 0.076 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.398591e-01 0.076 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.398591e-01 0.076 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.467622e-01 0.072 0 0
Glycosphingolipid transport R-HSA-9845576 8.482155e-01 0.071 0 0
DAP12 interactions R-HSA-2172127 8.484848e-01 0.071 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.515522e-01 0.070 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.515522e-01 0.070 0 0
Interleukin-1 signaling R-HSA-9020702 8.528308e-01 0.069 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.578567e-01 0.067 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.578567e-01 0.067 0 0
vRNA Synthesis R-HSA-192814 8.578567e-01 0.067 0 0
vRNP Assembly R-HSA-192905 8.578567e-01 0.067 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.578567e-01 0.067 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.578567e-01 0.067 0 0
Suppression of apoptosis R-HSA-9635465 8.578567e-01 0.067 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.578567e-01 0.067 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.595550e-01 0.066 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.602822e-01 0.065 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.624323e-01 0.064 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.624323e-01 0.064 0 0
GPCR downstream signalling R-HSA-388396 8.640171e-01 0.063 0 0
mRNA Capping R-HSA-72086 8.647172e-01 0.063 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.647172e-01 0.063 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.647172e-01 0.063 0 0
G alpha (z) signalling events R-HSA-418597 8.704640e-01 0.060 0 0
Mitochondrial biogenesis R-HSA-1592230 8.705758e-01 0.060 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.715193e-01 0.060 0 0
Vesicle-mediated transport R-HSA-5653656 8.747067e-01 0.058 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.763544e-01 0.057 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.763544e-01 0.057 0 0
NF-kB is activated and signals survival R-HSA-209560 8.763544e-01 0.057 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.763544e-01 0.057 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.763544e-01 0.057 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.763544e-01 0.057 0 0
Integration of provirus R-HSA-162592 8.763544e-01 0.057 0 0
G-protein activation R-HSA-202040 8.766203e-01 0.057 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.766203e-01 0.057 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.766203e-01 0.057 0 0
Neurotransmitter clearance R-HSA-112311 8.768429e-01 0.057 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.768429e-01 0.057 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.795160e-01 0.056 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.795160e-01 0.056 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.796666e-01 0.056 0 0
Downstream TCR signaling R-HSA-202424 8.810209e-01 0.055 0 0
RAS processing R-HSA-9648002 8.819679e-01 0.055 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.819679e-01 0.055 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.819679e-01 0.055 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.819679e-01 0.055 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.838753e-01 0.054 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.844633e-01 0.053 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.879933e-01 0.052 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.879933e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.879933e-01 0.052 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.894465e-01 0.051 0 0
Protein ubiquitination R-HSA-8852135 8.901096e-01 0.051 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.916692e-01 0.050 0 0
Glycogen metabolism R-HSA-8982491 8.916692e-01 0.050 0 0
Generation of second messenger molecules R-HSA-202433 8.916692e-01 0.050 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.924459e-01 0.049 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.924459e-01 0.049 0 0
Interleukin-15 signaling R-HSA-8983432 8.924459e-01 0.049 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.924459e-01 0.049 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.924459e-01 0.049 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.972672e-01 0.047 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.007988e-01 0.045 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.010250e-01 0.045 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.010250e-01 0.045 0 0
Fructose metabolism R-HSA-5652084 9.010250e-01 0.045 0 0
Phospholipid metabolism R-HSA-1483257 9.023662e-01 0.045 0 0
Regulated Necrosis R-HSA-5218859 9.032346e-01 0.044 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.035300e-01 0.044 0 0
Triglyceride metabolism R-HSA-8979227 9.035300e-01 0.044 0 0
Translation of Structural Proteins R-HSA-9694635 9.038533e-01 0.044 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.050908e-01 0.043 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.064440e-01 0.043 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.064440e-01 0.043 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.064440e-01 0.043 0 0
Chylomicron remodeling R-HSA-8963901 9.064440e-01 0.043 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.064440e-01 0.043 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.064440e-01 0.043 0 0
Interleukin-6 signaling R-HSA-1059683 9.064440e-01 0.043 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.076186e-01 0.042 0 0
Intra-Golgi traffic R-HSA-6811438 9.089928e-01 0.041 0 0
Translation of Structural Proteins R-HSA-9683701 9.089928e-01 0.041 0 0
PCP/CE pathway R-HSA-4086400 9.101610e-01 0.041 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.105623e-01 0.041 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.105623e-01 0.041 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.114632e-01 0.040 0 0
Mitochondrial protein degradation R-HSA-9837999 9.123997e-01 0.040 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.162137e-01 0.038 0 0
PPARA activates gene expression R-HSA-1989781 9.169805e-01 0.038 0 0
G alpha (s) signalling events R-HSA-418555 9.184925e-01 0.037 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.186209e-01 0.037 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.186209e-01 0.037 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.186209e-01 0.037 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.186209e-01 0.037 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.186209e-01 0.037 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.186209e-01 0.037 0 0
Physiological factors R-HSA-5578768 9.186209e-01 0.037 0 0
Prolactin receptor signaling R-HSA-1170546 9.186209e-01 0.037 0 0
Malate-aspartate shuttle R-HSA-9856872 9.186209e-01 0.037 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.186209e-01 0.037 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.186209e-01 0.037 0 0
Ciprofloxacin ADME R-HSA-9793528 9.186209e-01 0.037 0 0
Zinc transporters R-HSA-435354 9.186209e-01 0.037 0 0
P2Y receptors R-HSA-417957 9.186209e-01 0.037 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.208617e-01 0.036 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.208617e-01 0.036 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.208617e-01 0.036 0 0
Complex III assembly R-HSA-9865881 9.208617e-01 0.036 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.233020e-01 0.035 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.238085e-01 0.034 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.240735e-01 0.034 0 0
RA biosynthesis pathway R-HSA-5365859 9.240735e-01 0.034 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.249625e-01 0.034 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.292136e-01 0.032 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.292136e-01 0.032 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.292136e-01 0.032 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.292136e-01 0.032 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.292136e-01 0.032 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.292136e-01 0.032 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.292136e-01 0.032 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.292136e-01 0.032 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.292136e-01 0.032 0 0
DNA Damage Reversal R-HSA-73942 9.292136e-01 0.032 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.293143e-01 0.032 0 0
Hyaluronan degradation R-HSA-2160916 9.293143e-01 0.032 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.293143e-01 0.032 0 0
Regulation of Apoptosis R-HSA-169911 9.312520e-01 0.031 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.312520e-01 0.031 0 0
Leishmania infection R-HSA-9658195 9.336152e-01 0.030 0 0
Parasitic Infection Pathways R-HSA-9824443 9.336152e-01 0.030 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.366502e-01 0.028 0 0
MET activates PTK2 signaling R-HSA-8874081 9.369079e-01 0.028 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.369079e-01 0.028 0 0
Abacavir ADME R-HSA-2161522 9.369079e-01 0.028 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.369079e-01 0.028 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.373231e-01 0.028 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.384280e-01 0.028 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.384280e-01 0.028 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.384280e-01 0.028 0 0
Attachment and Entry R-HSA-9678110 9.384280e-01 0.028 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.384280e-01 0.028 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.384280e-01 0.028 0 0
Differentiation of T cells R-HSA-9945266 9.384280e-01 0.028 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.384280e-01 0.028 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.384280e-01 0.028 0 0
Atorvastatin ADME R-HSA-9754706 9.384280e-01 0.028 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.410863e-01 0.026 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.419841e-01 0.026 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.419841e-01 0.026 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.421441e-01 0.026 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.421441e-01 0.026 0 0
Cristae formation R-HSA-8949613 9.437230e-01 0.025 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.437230e-01 0.025 0 0
Signaling by BMP R-HSA-201451 9.437230e-01 0.025 0 0
Degradation of AXIN R-HSA-4641257 9.437680e-01 0.025 0 0
Degradation of DVL R-HSA-4641258 9.437680e-01 0.025 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.437680e-01 0.025 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.445373e-01 0.025 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.464434e-01 0.024 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.464434e-01 0.024 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.464434e-01 0.024 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.464434e-01 0.024 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.464434e-01 0.024 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.464434e-01 0.024 0 0
Phase 2 - plateau phase R-HSA-5576893 9.464434e-01 0.024 0 0
Fibronectin matrix formation R-HSA-1566977 9.464434e-01 0.024 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.464434e-01 0.024 0 0
Galactose catabolism R-HSA-70370 9.464434e-01 0.024 0 0
Coenzyme A biosynthesis R-HSA-196783 9.464434e-01 0.024 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.464434e-01 0.024 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.471020e-01 0.024 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.491999e-01 0.023 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.534158e-01 0.021 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.534158e-01 0.021 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.541393e-01 0.020 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.541393e-01 0.020 0 0
Pentose phosphate pathway R-HSA-71336 9.541393e-01 0.020 0 0
Toll-like Receptor Cascades R-HSA-168898 9.543635e-01 0.020 0 0
SLC transporter disorders R-HSA-5619102 9.558638e-01 0.020 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.594808e-01 0.018 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.594808e-01 0.018 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.594808e-01 0.018 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.594808e-01 0.018 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.602064e-01 0.018 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.619327e-01 0.017 0 0
Signaling by GPCR R-HSA-372790 9.623829e-01 0.017 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.626991e-01 0.017 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.627558e-01 0.016 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.636942e-01 0.016 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.636942e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.636942e-01 0.016 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.645878e-01 0.016 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.647565e-01 0.016 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.647565e-01 0.016 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.647565e-01 0.016 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.647565e-01 0.016 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.647565e-01 0.016 0 0
Diseases of hemostasis R-HSA-9671793 9.647565e-01 0.016 0 0
Neurotransmitter release cycle R-HSA-112310 9.649290e-01 0.016 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.659292e-01 0.015 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.670091e-01 0.015 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.670091e-01 0.015 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.685033e-01 0.014 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.693455e-01 0.014 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.693455e-01 0.014 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.693455e-01 0.014 0 0
Pregnenolone biosynthesis R-HSA-196108 9.693455e-01 0.014 0 0
Glycogen synthesis R-HSA-3322077 9.693455e-01 0.014 0 0
Interferon alpha/beta signaling R-HSA-909733 9.696429e-01 0.013 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.697380e-01 0.013 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.700401e-01 0.013 0 0
Leishmania phagocytosis R-HSA-9664417 9.710825e-01 0.013 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.710825e-01 0.013 0 0
Parasite infection R-HSA-9664407 9.710825e-01 0.013 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.727670e-01 0.012 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.728091e-01 0.012 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.733373e-01 0.012 0 0
Phenylalanine metabolism R-HSA-8964208 9.733373e-01 0.012 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.733373e-01 0.012 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.733373e-01 0.012 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.733373e-01 0.012 0 0
Basigin interactions R-HSA-210991 9.733373e-01 0.012 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.733373e-01 0.012 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.733373e-01 0.012 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.751200e-01 0.011 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.751200e-01 0.011 0 0
Heme degradation R-HSA-189483 9.751200e-01 0.011 0 0
Proteasome assembly R-HSA-9907900 9.755068e-01 0.011 0 0
Surfactant metabolism R-HSA-5683826 9.755068e-01 0.011 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.768094e-01 0.010 0 0
Attachment and Entry R-HSA-9694614 9.768094e-01 0.010 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.768094e-01 0.010 0 0
Assembly Of The HIV Virion R-HSA-175474 9.768094e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.768094e-01 0.010 0 0
Glutathione synthesis and recycling R-HSA-174403 9.768094e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.779027e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.779027e-01 0.010 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.779027e-01 0.010 0 0
Somitogenesis R-HSA-9824272 9.779832e-01 0.010 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.779832e-01 0.010 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.779832e-01 0.010 0 0
ABC transporter disorders R-HSA-5619084 9.796298e-01 0.009 0 0
Cholesterol biosynthesis R-HSA-191273 9.796298e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.798296e-01 0.009 0 0
Cellular hexose transport R-HSA-189200 9.798296e-01 0.009 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.803828e-01 0.009 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.813434e-01 0.008 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.824566e-01 0.008 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.824566e-01 0.008 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.824566e-01 0.008 0 0
Biosynthesis of maresins R-HSA-9018682 9.824566e-01 0.008 0 0
Interleukin-20 family signaling R-HSA-8854691 9.824566e-01 0.008 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.825918e-01 0.008 0 0
ER-Phagosome pathway R-HSA-1236974 9.826565e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.833999e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.845584e-01 0.007 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.845584e-01 0.007 0 0
CYP2E1 reactions R-HSA-211999 9.847415e-01 0.007 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.847415e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.847415e-01 0.007 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.847415e-01 0.007 0 0
Interleukin-6 family signaling R-HSA-6783589 9.847415e-01 0.007 0 0
Metabolism of cofactors R-HSA-8978934 9.851101e-01 0.007 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.854704e-01 0.006 0 0
ABC-family proteins mediated transport R-HSA-382556 9.864690e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.867290e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.867290e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.867290e-01 0.006 0 0
tRNA processing R-HSA-72306 9.882016e-01 0.005 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.884577e-01 0.005 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.884577e-01 0.005 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.884577e-01 0.005 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.892473e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.892473e-01 0.005 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.899614e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.899614e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.899614e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.899614e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.899614e-01 0.004 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.899614e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.904761e-01 0.004 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.904761e-01 0.004 0 0
Disease R-HSA-1643685 9.906636e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.907832e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.910849e-01 0.004 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.912257e-01 0.004 0 0
Prednisone ADME R-HSA-9757110 9.912692e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.912692e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.912692e-01 0.004 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.915673e-01 0.004 0 0
HIV Transcription Initiation R-HSA-167161 9.915673e-01 0.004 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.915673e-01 0.004 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.915673e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.917617e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.918585e-01 0.004 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.923762e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.924067e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.924067e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.924067e-01 0.003 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.933954e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.940112e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.941576e-01 0.003 0 0
Cargo concentration in the ER R-HSA-5694530 9.942565e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.942565e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.942565e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.942565e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.946349e-01 0.002 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.948334e-01 0.002 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.948334e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.948334e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.950049e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.952901e-01 0.002 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.954324e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.954324e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.956559e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.956559e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.956559e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.957943e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.959630e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.961056e-01 0.002 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.962220e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.962458e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.964329e-01 0.002 0 0
Gluconeogenesis R-HSA-70263 9.964329e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.965367e-01 0.002 0 0
Mitochondrial protein import R-HSA-1268020 9.966500e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.967144e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.968490e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.971426e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.971426e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.971426e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.971990e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.977136e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.977136e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.978390e-01 0.001 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.978390e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.978390e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.978390e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.980859e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.981139e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.981139e-01 0.001 0 0
Purine salvage R-HSA-74217 9.981207e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.981207e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.981207e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.983202e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.983337e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.983509e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.983657e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.985103e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.985788e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.986686e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.986735e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986861e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.988415e-01 0.001 0 0
Protein localization R-HSA-9609507 9.988419e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.988814e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.988814e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.989252e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.989460e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.989685e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.990030e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.990654e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.990998e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.991467e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991505e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991665e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.992067e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.992748e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993010e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.993854e-01 0.000 0 0
Neddylation R-HSA-8951664 9.994420e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.995224e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.995353e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995733e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.996222e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.996470e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996742e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996742e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996809e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997343e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.997343e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997343e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998048e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998048e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998048e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998048e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998427e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998430e-01 0.000 0 0
Digestion R-HSA-8935690 9.998680e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998833e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.998970e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999132e-01 0.000 0 0
Translation R-HSA-72766 9.999163e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999245e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999344e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999462e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999483e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999504e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999504e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999569e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999569e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999576e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999588e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999609e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999625e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999636e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999754e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999810e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999814e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999859e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999878e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999878e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999904e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999908e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999913e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999916e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999933e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999935e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999943e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999946e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999947e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999951e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999960e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999967e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999984e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999990e-01 0.000 1 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999990e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999990e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999997e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Metabolism of RNA R-HSA-8953854 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 4.440892e-16 15.353 0 0
Apoptotic execution phase R-HSA-75153 1.443290e-15 14.841 0 0
Cell Cycle R-HSA-1640170 2.331468e-15 14.632 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.703393e-13 12.568 0 0
Cell Cycle, Mitotic R-HSA-69278 3.567147e-13 12.448 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.935252e-13 12.227 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.055778e-13 12.094 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.055778e-13 12.094 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.367129e-12 11.864 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.099432e-12 11.678 0 0
HSF1-dependent transactivation R-HSA-3371571 2.354339e-12 11.628 0 0
M Phase R-HSA-68886 4.409362e-12 11.356 0 0
Apoptosis R-HSA-109581 4.761080e-12 11.322 0 0
Attenuation phase R-HSA-3371568 6.449397e-12 11.190 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.092793e-11 10.961 0 0
Nervous system development R-HSA-9675108 1.753397e-11 10.756 0 0
HSF1 activation R-HSA-3371511 2.616163e-11 10.582 0 0
Axon guidance R-HSA-422475 3.717027e-11 10.430 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.976072e-10 9.526 0 0
Cell Cycle Checkpoints R-HSA-69620 3.345390e-10 9.476 0 0
Signaling by ROBO receptors R-HSA-376176 7.387413e-10 9.132 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.577914e-10 9.067 0 0
Mitotic Anaphase R-HSA-68882 1.215210e-09 8.915 0 0
Influenza Infection R-HSA-168255 1.231586e-09 8.910 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.313350e-09 8.882 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.425746e-09 8.846 0 0
Cell-Cell communication R-HSA-1500931 3.738441e-09 8.427 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.270013e-09 8.370 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.368624e-09 8.360 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.726650e-09 8.242 0 0
Programmed Cell Death R-HSA-5357801 7.171168e-09 8.144 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.295453e-09 8.081 0 0
Separation of Sister Chromatids R-HSA-2467813 8.201099e-09 8.086 0 0
Peptide chain elongation R-HSA-156902 9.862084e-09 8.006 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.077782e-08 7.967 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.106004e-08 7.956 0 0
Translation initiation complex formation R-HSA-72649 1.154381e-08 7.938 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.501908e-08 7.823 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.675146e-08 7.776 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.185558e-08 7.660 0 0
Mitotic Prometaphase R-HSA-68877 3.061327e-08 7.514 0 0
mRNA Splicing R-HSA-72172 3.409796e-08 7.467 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.340721e-08 7.272 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.340721e-08 7.272 0 0
Ribosome-associated quality control R-HSA-9948299 5.163208e-08 7.287 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.365566e-08 7.196 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.549666e-08 7.184 0 0
Signaling by Hippo R-HSA-2028269 8.693708e-08 7.061 0 0
Cell junction organization R-HSA-446728 1.204731e-07 6.919 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.378734e-07 6.861 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.524150e-07 6.817 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.667104e-07 6.778 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.901393e-07 6.721 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.477751e-07 6.606 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.477751e-07 6.606 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.491915e-07 6.260 0 0
Eukaryotic Translation Termination R-HSA-72764 6.773113e-07 6.169 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.811577e-07 6.008 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.027234e-06 5.988 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.235793e-06 5.908 0 0
rRNA processing R-HSA-72312 1.424443e-06 5.846 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.615984e-06 5.792 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.866408e-06 5.729 0 0
Selenocysteine synthesis R-HSA-2408557 2.158348e-06 5.666 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.451086e-06 5.611 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.674968e-06 5.573 0 0
Viral mRNA Translation R-HSA-192823 3.108775e-06 5.507 0 0
G2/M Transition R-HSA-69275 3.377206e-06 5.471 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.690865e-06 5.433 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.690865e-06 5.433 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.570109e-06 5.447 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.237150e-06 5.373 0 0
Regulation of CDH1 Function R-HSA-9764561 4.264890e-06 5.370 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.358275e-06 5.361 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.718034e-06 5.326 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.704829e-06 5.244 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.819907e-06 5.235 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.411735e-06 5.130 0 0
Signaling by ALK in cancer R-HSA-9700206 7.411735e-06 5.130 0 0
G2/M Checkpoints R-HSA-69481 8.404227e-06 5.076 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.193444e-06 5.037 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.193444e-06 5.037 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.193444e-06 5.037 0 0
Signaling by RAS mutants R-HSA-6802949 9.193444e-06 5.037 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.886578e-06 5.051 0 0
Adherens junctions interactions R-HSA-418990 9.715496e-06 5.013 0 0
Gene expression (Transcription) R-HSA-74160 1.065773e-05 4.972 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.186757e-05 4.926 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.235155e-05 4.908 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.335331e-05 4.874 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.352170e-05 4.869 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.364179e-05 4.865 0 0
Signal Transduction R-HSA-162582 1.391313e-05 4.857 0 0
Interferon Signaling R-HSA-913531 1.548625e-05 4.810 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.473522e-05 4.832 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.634103e-05 4.787 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.667848e-05 4.778 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.853229e-05 4.732 0 0
Host Interactions of HIV factors R-HSA-162909 2.495763e-05 4.603 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.588487e-05 4.587 0 0
Signaling by Interleukins R-HSA-449147 2.657117e-05 4.576 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.792450e-05 4.554 0 0
Interleukin-12 signaling R-HSA-9020591 2.966569e-05 4.528 0 0
Cellular Senescence R-HSA-2559583 3.086380e-05 4.511 0 0
Chromatin organization R-HSA-4839726 3.468228e-05 4.460 0 0
Cellular response to starvation R-HSA-9711097 3.586456e-05 4.445 0 0
Interleukin-12 family signaling R-HSA-447115 3.785206e-05 4.422 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.106321e-05 4.387 0 0
Cell-cell junction organization R-HSA-421270 4.211014e-05 4.376 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.300903e-05 4.366 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.491699e-05 4.348 0 0
Smooth Muscle Contraction R-HSA-445355 4.954879e-05 4.305 0 0
Chromatin modifying enzymes R-HSA-3247509 5.228428e-05 4.282 0 0
Aggrephagy R-HSA-9646399 5.541176e-05 4.256 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.617067e-05 4.250 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.735939e-05 4.241 0 0
PKR-mediated signaling R-HSA-9833482 6.152433e-05 4.211 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.542640e-05 4.184 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.638100e-05 4.117 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.439493e-05 4.128 0 0
Mitotic Prophase R-HSA-68875 7.227835e-05 4.141 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.326578e-05 4.080 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.512708e-05 4.070 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.764400e-05 4.057 0 0
Viral Infection Pathways R-HSA-9824446 9.598457e-05 4.018 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.982512e-05 4.001 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.004464e-04 3.998 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.070660e-04 3.970 0 0
Recycling pathway of L1 R-HSA-437239 1.175784e-04 3.930 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.308700e-04 3.883 0 0
Nuclear import of Rev protein R-HSA-180746 1.308700e-04 3.883 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.341134e-04 3.873 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.341134e-04 3.873 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.401909e-04 3.853 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.699231e-04 3.770 0 0
Translation R-HSA-72766 1.720356e-04 3.764 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.778634e-04 3.750 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.814064e-04 3.741 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.127440e-04 3.672 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.053017e-04 3.688 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.053017e-04 3.688 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.164189e-04 3.665 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.240449e-04 3.650 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.317313e-04 3.635 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.588341e-04 3.587 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.605885e-04 3.584 0 0
Neutrophil degranulation R-HSA-6798695 2.702680e-04 3.568 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.711754e-04 3.567 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.749146e-04 3.561 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.856591e-04 3.544 0 0
MAP2K and MAPK activation R-HSA-5674135 2.802821e-04 3.552 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.014007e-04 3.521 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.953963e-04 3.530 0 0
HIV Infection R-HSA-162906 3.058813e-04 3.514 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.213914e-04 3.493 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.273540e-04 3.485 0 0
mRNA 3'-end processing R-HSA-72187 3.303309e-04 3.481 0 0
Striated Muscle Contraction R-HSA-390522 3.345577e-04 3.476 0 0
Regulation of TP53 Activity R-HSA-5633007 3.666846e-04 3.436 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.776755e-04 3.423 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.027435e-04 3.395 0 0
Centrosome maturation R-HSA-380287 4.158039e-04 3.381 0 0
L1CAM interactions R-HSA-373760 4.327930e-04 3.364 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.336589e-04 3.363 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.485844e-04 3.348 0 0
Metabolism of non-coding RNA R-HSA-194441 4.517152e-04 3.345 0 0
snRNP Assembly R-HSA-191859 4.517152e-04 3.345 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.558418e-04 3.341 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.180062e-04 3.286 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.180062e-04 3.286 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.087709e-04 3.293 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.369299e-04 3.270 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.388694e-04 3.269 0 0
EPH-Ephrin signaling R-HSA-2682334 5.430399e-04 3.265 0 0
Selenoamino acid metabolism R-HSA-2408522 5.511550e-04 3.259 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.520699e-04 3.258 0 0
Gap junction degradation R-HSA-190873 5.996108e-04 3.222 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.222126e-04 3.206 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.261760e-04 3.203 0 0
Regulation of signaling by CBL R-HSA-912631 6.269875e-04 3.203 0 0
DNA Double Strand Break Response R-HSA-5693606 6.890504e-04 3.162 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.303210e-04 3.136 0 0
Glycolysis R-HSA-70171 8.142776e-04 3.089 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.334964e-04 3.079 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.350342e-04 3.078 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.350342e-04 3.078 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.808003e-04 3.055 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.652457e-04 3.015 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.941877e-04 3.003 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.510878e-04 3.022 0 0
HIV Life Cycle R-HSA-162587 9.762954e-04 3.010 0 0
Developmental Biology R-HSA-1266738 9.375428e-04 3.028 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.988517e-04 3.000 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.030070e-03 2.987 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.043709e-03 2.981 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.053260e-03 2.977 0 0
RNA Polymerase II Transcription R-HSA-73857 1.222371e-03 2.913 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.249024e-03 2.903 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.249024e-03 2.903 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.262010e-03 2.899 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.296482e-03 2.887 0 0
Selective autophagy R-HSA-9663891 1.348294e-03 2.870 0 0
Degradation of CDH1 R-HSA-9766229 1.353297e-03 2.869 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.353297e-03 2.869 0 0
Gap junction trafficking and regulation R-HSA-157858 1.353297e-03 2.869 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.398018e-03 2.854 0 0
Muscle contraction R-HSA-397014 1.423853e-03 2.847 0 0
PECAM1 interactions R-HSA-210990 1.447492e-03 2.839 0 0
HDACs deacetylate histones R-HSA-3214815 1.475284e-03 2.831 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.498211e-03 2.824 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.503666e-03 2.823 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.571402e-03 2.804 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.601015e-03 2.796 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.624494e-03 2.789 0 0
Ephrin signaling R-HSA-3928664 1.757465e-03 2.755 0 0
mTORC1-mediated signalling R-HSA-166208 1.946373e-03 2.711 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.831340e-03 2.737 0 0
PTEN Regulation R-HSA-6807070 1.879970e-03 2.726 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.858098e-03 2.731 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.946461e-03 2.711 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.955893e-03 2.709 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.990807e-03 2.701 0 0
p75NTR signals via NF-kB R-HSA-193639 1.990807e-03 2.701 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.990807e-03 2.701 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.030682e-03 2.692 0 0
Formation of annular gap junctions R-HSA-196025 2.030682e-03 2.692 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.125933e-03 2.672 0 0
NF-kB is activated and signals survival R-HSA-209560 2.125933e-03 2.672 0 0
Semaphorin interactions R-HSA-373755 2.126589e-03 2.672 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.151545e-03 2.667 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.302258e-03 2.638 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.485073e-03 2.605 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.485073e-03 2.605 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.496863e-03 2.603 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.027129e-03 2.519 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.027129e-03 2.519 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.041953e-03 2.517 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.107566e-03 2.508 0 0
HCMV Early Events R-HSA-9609690 3.138718e-03 2.503 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.147814e-03 2.502 0 0
Signaling by ERBB2 R-HSA-1227986 3.189103e-03 2.496 0 0
Dual Incision in GG-NER R-HSA-5696400 3.684923e-03 2.434 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.274248e-03 2.485 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.755665e-03 2.425 0 0
DNA Damage Bypass R-HSA-73893 3.406962e-03 2.468 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.628345e-03 2.440 0 0
Stabilization of p53 R-HSA-69541 3.443089e-03 2.463 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.754445e-03 2.425 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.684923e-03 2.434 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.406962e-03 2.468 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.406962e-03 2.468 0 0
Gap junction trafficking R-HSA-190828 3.755665e-03 2.425 0 0
RMTs methylate histone arginines R-HSA-3214858 3.755665e-03 2.425 0 0
SARS-CoV Infections R-HSA-9679506 3.425327e-03 2.465 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.873811e-03 2.412 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.919132e-03 2.407 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.040589e-03 2.394 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.105862e-03 2.387 0 0
Macroautophagy R-HSA-1632852 4.136354e-03 2.383 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.137944e-03 2.383 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.229404e-03 2.374 0 0
Co-inhibition by PD-1 R-HSA-389948 4.245433e-03 2.372 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.375737e-03 2.359 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.561931e-03 2.341 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.561931e-03 2.341 0 0
S Phase R-HSA-69242 4.653706e-03 2.332 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.659909e-03 2.332 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.727541e-03 2.325 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.756634e-03 2.323 0 0
G1/S Transition R-HSA-69206 4.831579e-03 2.316 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.845646e-03 2.315 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.867989e-03 2.313 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.920506e-03 2.308 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.923123e-03 2.308 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.972741e-03 2.303 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.972741e-03 2.303 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.174553e-03 2.286 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.174553e-03 2.286 0 0
Autophagy R-HSA-9612973 5.185897e-03 2.285 0 0
Notch-HLH transcription pathway R-HSA-350054 6.239708e-03 2.205 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.312511e-03 2.275 0 0
Orc1 removal from chromatin R-HSA-68949 5.376440e-03 2.270 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.376440e-03 2.270 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.207436e-03 2.207 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.207436e-03 2.207 0 0
Dual incision in TC-NER R-HSA-6782135 5.490834e-03 2.260 0 0
Chromosome Maintenance R-HSA-73886 5.572141e-03 2.254 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.246445e-03 2.204 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.246445e-03 2.204 0 0
Degradation of DVL R-HSA-4641258 6.317058e-03 2.199 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.164984e-03 2.210 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.535288e-03 2.257 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.164984e-03 2.210 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.723968e-03 2.242 0 0
Regulation of KIT signaling R-HSA-1433559 5.674589e-03 2.246 0 0
ESR-mediated signaling R-HSA-8939211 5.341775e-03 2.272 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.056698e-03 2.218 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.747278e-03 2.171 0 0
Regulation of PTEN localization R-HSA-8948747 6.747278e-03 2.171 0 0
RNA Polymerase I Transcription R-HSA-73864 6.908109e-03 2.161 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.963318e-03 2.157 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.996536e-03 2.155 0 0
DNA Replication R-HSA-69306 7.012495e-03 2.154 0 0
Glucose metabolism R-HSA-70326 7.049940e-03 2.152 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.138694e-03 2.146 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.138694e-03 2.146 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.182157e-03 2.144 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.182157e-03 2.144 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.182157e-03 2.144 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.182157e-03 2.144 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.182157e-03 2.144 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.182157e-03 2.144 0 0
Membrane Trafficking R-HSA-199991 7.182236e-03 2.144 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.513824e-03 2.124 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.513824e-03 2.124 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.513824e-03 2.124 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.513824e-03 2.124 0 0
Meiosis R-HSA-1500620 7.515263e-03 2.124 0 0
Synthesis of DNA R-HSA-69239 7.798768e-03 2.108 0 0
Gene Silencing by RNA R-HSA-211000 7.798768e-03 2.108 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.848339e-03 2.105 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.848339e-03 2.105 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.178448e-03 2.087 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.588523e-03 2.066 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.721010e-03 2.059 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.885505e-03 2.051 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.885505e-03 2.051 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.121172e-03 2.040 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 9.897366e-03 2.004 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.760025e-03 2.011 0 0
Deadenylation of mRNA R-HSA-429947 9.503643e-03 2.022 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.145624e-02 1.941 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.335180e-03 2.030 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.033037e-02 1.986 0 0
Signaling by EGFR R-HSA-177929 9.335180e-03 2.030 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.145624e-02 1.941 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.025143e-02 1.989 0 0
Prolonged ERK activation events R-HSA-169893 9.760025e-03 2.011 0 0
Protein folding R-HSA-391251 9.894098e-03 2.005 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.145624e-02 1.941 0 0
Regulation of Apoptosis R-HSA-169911 1.145624e-02 1.941 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.064989e-02 1.973 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.114885e-02 1.953 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.064391e-02 1.973 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.728105e-03 2.012 0 0
Signaling by NOTCH R-HSA-157118 1.010755e-02 1.995 0 0
Signaling by NOTCH1 R-HSA-1980143 1.114885e-02 1.953 0 0
tRNA processing in the nucleus R-HSA-6784531 9.268481e-03 2.033 0 0
Generic Transcription Pathway R-HSA-212436 1.104405e-02 1.957 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.054175e-02 1.977 0 0
TCR signaling R-HSA-202403 1.029862e-02 1.987 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.054175e-02 1.977 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.054175e-02 1.977 0 0
Negative regulation of FLT3 R-HSA-9706369 9.760025e-03 2.011 0 0
Nephrin family interactions R-HSA-373753 9.855296e-03 2.006 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.897366e-03 2.004 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.150718e-02 1.939 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.180979e-02 1.928 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.180979e-02 1.928 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.180979e-02 1.928 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.180979e-02 1.928 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.180979e-02 1.928 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.189457e-02 1.925 0 0
Nucleotide Excision Repair R-HSA-5696398 1.190507e-02 1.924 0 0
Signaling by TGFB family members R-HSA-9006936 1.191377e-02 1.924 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.191575e-02 1.924 0 0
FLT3 Signaling R-HSA-9607240 1.191575e-02 1.924 0 0
DNA Repair R-HSA-73894 1.215625e-02 1.915 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.222033e-02 1.913 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.222033e-02 1.913 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.222033e-02 1.913 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.222033e-02 1.913 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.246032e-02 1.904 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.287216e-02 1.890 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.340933e-02 1.873 0 0
Meiotic synapsis R-HSA-1221632 1.381572e-02 1.860 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.381572e-02 1.860 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.389408e-02 1.857 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.391562e-02 1.856 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.393254e-02 1.856 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.393254e-02 1.856 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.436113e-02 1.843 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.462674e-02 1.835 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.488777e-02 1.827 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.488777e-02 1.827 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.488777e-02 1.827 0 0
Maturation of protein E R-HSA-9683683 1.488777e-02 1.827 0 0
Maturation of protein E R-HSA-9694493 1.488777e-02 1.827 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.894749e-02 1.722 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.894749e-02 1.722 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.555729e-02 1.808 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.566050e-02 1.805 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.566050e-02 1.805 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.815992e-02 1.741 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.661765e-02 1.779 0 0
HIV elongation arrest and recovery R-HSA-167287 1.968448e-02 1.706 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.968448e-02 1.706 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.964358e-02 1.707 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.776690e-02 1.750 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.870450e-02 1.728 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.565536e-02 1.805 0 0
Frs2-mediated activation R-HSA-170968 1.555729e-02 1.808 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.993454e-02 1.700 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.497749e-02 1.825 0 0
Nuclear RNA decay R-HSA-9930044 1.758713e-02 1.755 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.560448e-02 1.807 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.694328e-02 1.771 0 0
Signaling by WNT R-HSA-195721 1.514211e-02 1.820 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.850923e-02 1.733 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.658446e-02 1.780 0 0
Josephin domain DUBs R-HSA-5689877 1.894749e-02 1.722 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.940422e-02 1.712 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.585864e-02 1.800 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.758713e-02 1.755 0 0
Signaling by MET R-HSA-6806834 1.694328e-02 1.771 0 0
Post NMDA receptor activation events R-HSA-438064 1.952154e-02 1.709 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.718305e-02 1.765 0 0
Pexophagy R-HSA-9664873 1.894749e-02 1.722 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.497749e-02 1.825 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.555729e-02 1.808 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.585864e-02 1.800 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.714753e-02 1.766 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.801363e-02 1.744 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.038205e-02 1.691 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.049414e-02 1.688 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.071538e-02 1.684 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.078864e-02 1.682 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.119567e-02 1.674 0 0
Signaling by PTK6 R-HSA-8848021 2.145483e-02 1.668 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.145483e-02 1.668 0 0
Nef and signal transduction R-HSA-164944 2.180822e-02 1.661 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.227371e-02 1.652 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.279604e-02 1.642 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.279604e-02 1.642 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.310564e-02 1.636 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.310564e-02 1.636 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.310564e-02 1.636 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.310564e-02 1.636 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.310564e-02 1.636 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.314062e-02 1.636 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.352145e-02 1.629 0 0
Nucleosome assembly R-HSA-774815 2.352145e-02 1.629 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.352145e-02 1.629 0 0
Translesion Synthesis by POLH R-HSA-110320 2.373218e-02 1.625 0 0
Rap1 signalling R-HSA-392517 2.373218e-02 1.625 0 0
RAF activation R-HSA-5673000 2.373671e-02 1.625 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.373671e-02 1.625 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.381071e-02 1.623 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.381071e-02 1.623 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.390615e-02 1.621 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.484170e-02 1.605 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.502254e-02 1.602 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.502254e-02 1.602 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.508100e-02 1.601 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.508100e-02 1.601 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.508100e-02 1.601 0 0
Translesion synthesis by REV1 R-HSA-110312 2.508100e-02 1.601 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.508100e-02 1.601 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.508100e-02 1.601 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.525251e-02 1.598 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.546570e-02 1.594 0 0
Signaling by VEGF R-HSA-194138 2.557820e-02 1.592 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.582041e-02 1.588 0 0
PCP/CE pathway R-HSA-4086400 2.630018e-02 1.580 0 0
MAPK family signaling cascades R-HSA-5683057 2.644925e-02 1.578 0 0
Cellular response to hypoxia R-HSA-1234174 2.648277e-02 1.577 0 0
Activation of BH3-only proteins R-HSA-114452 2.700938e-02 1.568 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.714070e-02 1.566 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.714070e-02 1.566 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.714070e-02 1.566 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.714070e-02 1.566 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.733376e-02 1.563 0 0
Signalling to ERKs R-HSA-187687 2.733376e-02 1.563 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.779290e-02 1.556 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.846273e-02 1.546 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.868149e-02 1.542 0 0
Signal transduction by L1 R-HSA-445144 2.868149e-02 1.542 0 0
Negative regulation of MET activity R-HSA-6807004 2.868149e-02 1.542 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.868149e-02 1.542 0 0
Protein hydroxylation R-HSA-9629569 2.868149e-02 1.542 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.890837e-02 1.539 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.040980e-02 1.517 0 0
Long-term potentiation R-HSA-9620244 3.056657e-02 1.515 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.079373e-02 1.512 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.079373e-02 1.512 0 0
Kinesins R-HSA-983189 3.080282e-02 1.511 0 0
Translesion synthesis by POLI R-HSA-5656121 3.104410e-02 1.508 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.104410e-02 1.508 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.124069e-02 1.505 0 0
EGFR downregulation R-HSA-182971 3.131261e-02 1.504 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.131261e-02 1.504 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.131261e-02 1.504 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.222199e-02 1.492 0 0
Signaling by NOTCH4 R-HSA-9013694 3.356159e-02 1.474 0 0
Regulation of gap junction activity R-HSA-191650 3.367473e-02 1.473 0 0
NADE modulates death signalling R-HSA-205025 3.367473e-02 1.473 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.367473e-02 1.473 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.367473e-02 1.473 0 0
MTOR signalling R-HSA-165159 3.478411e-02 1.459 0 0
Degradation of AXIN R-HSA-4641257 3.566187e-02 1.448 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.566187e-02 1.448 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.574702e-02 1.447 0 0
G0 and Early G1 R-HSA-1538133 3.607042e-02 1.443 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.616034e-02 1.442 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.821195e-02 1.317 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.919265e-02 1.308 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.919265e-02 1.308 0 0
IRS activation R-HSA-74713 4.919265e-02 1.308 0 0
ARMS-mediated activation R-HSA-170984 5.284779e-02 1.277 0 0
WNT mediated activation of DVL R-HSA-201688 5.284779e-02 1.277 0 0
Translesion synthesis by POLK R-HSA-5655862 3.786313e-02 1.422 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.418234e-02 1.266 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.781161e-02 1.320 0 0
Integrin signaling R-HSA-354192 4.130096e-02 1.384 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.472991e-02 1.262 0 0
DNA methylation R-HSA-5334118 5.472991e-02 1.262 0 0
Late endosomal microautophagy R-HSA-9615710 5.472991e-02 1.262 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.702022e-02 1.328 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.702022e-02 1.328 0 0
MET promotes cell motility R-HSA-8875878 4.042512e-02 1.393 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.324184e-02 1.274 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.121948e-02 1.291 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.437016e-02 1.265 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.437016e-02 1.265 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.645852e-02 1.333 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.140358e-02 1.289 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.281142e-02 1.368 0 0
Deubiquitination R-HSA-5688426 4.813661e-02 1.318 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.325369e-02 1.274 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.224373e-02 1.282 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.890774e-02 1.311 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.919265e-02 1.308 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.059305e-02 1.392 0 0
Homology Directed Repair R-HSA-5693538 3.912976e-02 1.407 0 0
ER-Phagosome pathway R-HSA-1236974 4.152160e-02 1.382 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.207187e-02 1.376 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.093690e-02 1.388 0 0
HCMV Infection R-HSA-9609646 5.395101e-02 1.268 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.821195e-02 1.317 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.781161e-02 1.320 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.472991e-02 1.262 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.472991e-02 1.262 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.418234e-02 1.266 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.284779e-02 1.277 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.079617e-02 1.389 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.981917e-02 1.400 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.912522e-02 1.408 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.786313e-02 1.422 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.870191e-02 1.312 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.284779e-02 1.277 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.059305e-02 1.392 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.059305e-02 1.392 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.890774e-02 1.311 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.756261e-02 1.323 0 0
Immune System R-HSA-168256 4.863324e-02 1.313 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.075057e-02 1.390 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.645852e-02 1.333 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.763970e-02 1.424 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.061606e-02 1.296 0 0
Signaling by ALK R-HSA-201556 4.560690e-02 1.341 0 0
Defective pyroptosis R-HSA-9710421 3.912522e-02 1.408 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.977702e-02 1.400 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.248841e-02 1.372 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.788162e-02 1.320 0 0
IRE1alpha activates chaperones R-HSA-381070 5.237799e-02 1.281 0 0
Modulation by Mtb of host immune system R-HSA-9637628 4.075057e-02 1.390 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.549254e-02 1.256 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.634587e-02 1.249 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.669435e-02 1.246 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.727341e-02 1.242 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.991601e-02 1.222 0 0
Oncogene Induced Senescence R-HSA-2559585 5.997698e-02 1.222 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.022517e-02 1.220 0 0
Reproduction R-HSA-1474165 6.070826e-02 1.217 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.095229e-02 1.215 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.095229e-02 1.215 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.095229e-02 1.215 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.225572e-02 1.206 0 0
Activation of the pre-replicative complex R-HSA-68962 6.225572e-02 1.206 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.225572e-02 1.206 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.371638e-02 1.196 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.372753e-02 1.196 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.377735e-02 1.195 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.377735e-02 1.195 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.377735e-02 1.195 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.377735e-02 1.195 0 0
MAP kinase activation R-HSA-450294 6.379357e-02 1.195 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.525414e-02 1.185 0 0
Diseases of programmed cell death R-HSA-9645723 6.537606e-02 1.185 0 0
Gluconeogenesis R-HSA-70263 6.647985e-02 1.177 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.668179e-02 1.176 0 0
2-LTR circle formation R-HSA-164843 6.668179e-02 1.176 0 0
Regulation of CDH11 function R-HSA-9762292 6.668179e-02 1.176 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.668179e-02 1.176 0 0
Ub-specific processing proteases R-HSA-5689880 6.703379e-02 1.174 0 0
G1/S-Specific Transcription R-HSA-69205 6.723420e-02 1.172 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.758937e-02 1.170 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.758937e-02 1.170 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.758937e-02 1.170 0 0
Phosphorylation of Emi1 R-HSA-176417 6.758937e-02 1.170 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.758937e-02 1.170 0 0
Signaling by NOTCH3 R-HSA-9012852 6.834044e-02 1.165 0 0
Trafficking of AMPA receptors R-HSA-399719 7.039697e-02 1.152 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.039697e-02 1.152 0 0
UCH proteinases R-HSA-5689603 7.054179e-02 1.152 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.224490e-02 1.141 0 0
HDMs demethylate histones R-HSA-3214842 7.291946e-02 1.137 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.291946e-02 1.137 0 0
Interleukin-7 signaling R-HSA-1266695 7.291946e-02 1.137 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.294928e-02 1.137 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.294928e-02 1.137 0 0
Protein methylation R-HSA-8876725 7.294928e-02 1.137 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.294928e-02 1.137 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.380342e-02 1.132 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.417399e-02 1.130 0 0
Ion homeostasis R-HSA-5578775 7.470659e-02 1.127 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.563300e-02 1.121 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.816014e-02 1.107 0 0
Signaling by SCF-KIT R-HSA-1433557 7.816014e-02 1.107 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.816014e-02 1.107 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.915779e-02 1.102 0 0
Regulation of TP53 Expression R-HSA-6804754 7.954698e-02 1.099 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 7.954698e-02 1.099 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.954698e-02 1.099 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.975950e-02 1.098 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.218378e-02 1.085 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.243302e-02 1.084 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.243302e-02 1.084 0 0
Metalloprotease DUBs R-HSA-5689901 8.285396e-02 1.082 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.285396e-02 1.082 0 0
Telomere Maintenance R-HSA-157579 8.509720e-02 1.070 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.613719e-02 1.065 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.613719e-02 1.065 0 0
Phosphorylation of the APC/C R-HSA-176412 8.613719e-02 1.065 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.613719e-02 1.065 0 0
Meiotic recombination R-HSA-912446 8.768995e-02 1.057 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.853847e-02 1.053 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.853847e-02 1.053 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.853847e-02 1.053 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.853847e-02 1.053 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.853847e-02 1.053 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.066208e-02 1.043 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.066208e-02 1.043 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.066208e-02 1.043 0 0
Developmental Cell Lineages R-HSA-9734767 9.213608e-02 1.036 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.352622e-02 1.029 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.352622e-02 1.029 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.352622e-02 1.029 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.352622e-02 1.029 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.439729e-02 1.025 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.558344e-02 1.020 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.558344e-02 1.020 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.558344e-02 1.020 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.782830e-02 1.010 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.782830e-02 1.010 0 0
Integration of provirus R-HSA-162592 9.932428e-02 1.003 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 9.932428e-02 1.003 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.004824e-01 0.998 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.004824e-01 0.998 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.004824e-01 0.998 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.004824e-01 0.998 0 0
Disorders of Developmental Biology R-HSA-9675151 1.004824e-01 0.998 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.004824e-01 0.998 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.015598e-01 0.993 0 0
Glycogen metabolism R-HSA-8982491 1.015598e-01 0.993 0 0
Generation of second messenger molecules R-HSA-202433 1.015598e-01 0.993 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.016607e-01 0.993 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.021461e-01 0.991 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.023864e-01 0.990 0 0
Cilium Assembly R-HSA-5617833 1.040488e-01 0.983 0 0
Interleukin-1 signaling R-HSA-9020702 1.087300e-01 0.964 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.091415e-01 0.962 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.091415e-01 0.962 0 0
Gap junction assembly R-HSA-190861 1.091415e-01 0.962 0 0
Mitophagy R-HSA-5205647 1.091415e-01 0.962 0 0
Death Receptor Signaling R-HSA-73887 1.093586e-01 0.961 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.095862e-01 0.960 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.095862e-01 0.960 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.095862e-01 0.960 0 0
Protein ubiquitination R-HSA-8852135 1.097359e-01 0.960 0 0
Iron uptake and transport R-HSA-917937 1.097359e-01 0.960 0 0
Platelet degranulation R-HSA-114608 1.103005e-01 0.957 0 0
Cellular response to chemical stress R-HSA-9711123 1.107933e-01 0.955 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.109883e-01 0.955 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.109883e-01 0.955 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.109883e-01 0.955 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.109883e-01 0.955 0 0
Signaling by KIT in disease R-HSA-9669938 1.109883e-01 0.955 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.114603e-01 0.953 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.120391e-01 0.951 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.120391e-01 0.951 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.120391e-01 0.951 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.120391e-01 0.951 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.120391e-01 0.951 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.120391e-01 0.951 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.120738e-01 0.950 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.124851e-01 0.949 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.125705e-01 0.949 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.146187e-01 0.941 0 0
MET interacts with TNS proteins R-HSA-8875513 1.154455e-01 0.938 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.154455e-01 0.938 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.154455e-01 0.938 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.154455e-01 0.938 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.159384e-01 0.936 0 0
Glycogen storage diseases R-HSA-3229121 1.159384e-01 0.936 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.160730e-01 0.935 0 0
Platelet calcium homeostasis R-HSA-418360 1.170379e-01 0.932 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.170379e-01 0.932 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.178034e-01 0.929 0 0
Signaling by NTRKs R-HSA-166520 1.178034e-01 0.929 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.179510e-01 0.928 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.179510e-01 0.928 0 0
Repression of WNT target genes R-HSA-4641265 1.179510e-01 0.928 0 0
Regulation of IFNG signaling R-HSA-877312 1.179510e-01 0.928 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.179510e-01 0.928 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.179510e-01 0.928 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.189687e-01 0.925 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.206528e-01 0.918 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.222128e-01 0.913 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.235399e-01 0.908 0 0
MHC class II antigen presentation R-HSA-2132295 1.254065e-01 0.902 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.071689e-01 0.684 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.071689e-01 0.684 0 0
Hereditary fructose intolerance R-HSA-5657560 2.071689e-01 0.684 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.071689e-01 0.684 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.071689e-01 0.684 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.071689e-01 0.684 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.071689e-01 0.684 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.071689e-01 0.684 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.071689e-01 0.684 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.545321e-01 0.811 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.956779e-01 0.708 0 0
Type I hemidesmosome assembly R-HSA-446107 1.375039e-01 0.862 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.375039e-01 0.862 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.375039e-01 0.862 0 0
Calcineurin activates NFAT R-HSA-2025928 1.647066e-01 0.783 0 0
ALK mutants bind TKIs R-HSA-9700645 1.647066e-01 0.783 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.379627e-01 0.623 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.379627e-01 0.623 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.379627e-01 0.623 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.933278e-01 0.714 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.592202e-01 0.798 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.324477e-01 0.878 0 0
Polo-like kinase mediated events R-HSA-156711 1.324477e-01 0.878 0 0
GAB1 signalosome R-HSA-180292 1.324477e-01 0.878 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.398256e-01 0.854 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.049123e-01 0.688 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.535996e-01 0.596 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.875852e-01 0.727 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.290465e-01 0.640 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.887401e-01 0.724 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.245168e-01 0.649 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.847270e-01 0.733 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.991118e-01 0.701 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.362767e-01 0.627 0 0
Signaling by ERBB4 R-HSA-1236394 1.645012e-01 0.784 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.205970e-01 0.656 0 0
RNA Polymerase III Transcription R-HSA-74158 2.362767e-01 0.627 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.388567e-01 0.857 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.535306e-01 0.814 0 0
Interferon alpha/beta signaling R-HSA-909733 2.481192e-01 0.605 0 0
HATs acetylate histones R-HSA-3214847 1.474727e-01 0.831 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.535996e-01 0.596 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.445867e-01 0.612 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.887401e-01 0.724 0 0
DCC mediated attractive signaling R-HSA-418885 1.815867e-01 0.741 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.379627e-01 0.623 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.049123e-01 0.688 0 0
DNA strand elongation R-HSA-69190 1.574210e-01 0.803 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.534226e-01 0.596 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.379608e-01 0.860 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.815867e-01 0.741 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.118539e-01 0.674 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.118539e-01 0.674 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.392830e-01 0.621 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.392830e-01 0.621 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.409780e-01 0.618 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.956779e-01 0.708 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.815867e-01 0.741 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.290465e-01 0.640 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.887401e-01 0.724 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.684597e-01 0.774 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.431793e-01 0.614 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.429007e-01 0.845 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.499430e-01 0.824 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.379608e-01 0.860 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.295937e-01 0.887 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.592202e-01 0.798 0 0
Signaling by FGFR2 R-HSA-5654738 2.286395e-01 0.641 0 0
Co-stimulation by CD28 R-HSA-389356 2.080756e-01 0.682 0 0
Circadian clock R-HSA-9909396 2.060662e-01 0.686 0 0
Signal attenuation R-HSA-74749 1.933278e-01 0.714 0 0
Interleukin-17 signaling R-HSA-448424 1.275941e-01 0.894 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.063501e-01 0.685 0 0
Signaling by FGFR4 R-HSA-5654743 1.442142e-01 0.841 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.172928e-01 0.663 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.032298e-01 0.692 0 0
Glycogen synthesis R-HSA-3322077 1.683493e-01 0.774 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.799832e-01 0.745 0 0
Vesicle-mediated transport R-HSA-5653656 1.918810e-01 0.717 0 0
Signaling by FGFR3 R-HSA-5654741 1.684597e-01 0.774 0 0
Signaling by FGFR1 R-HSA-5654736 2.150799e-01 0.667 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.071689e-01 0.684 0 0
Inhibition of PKR R-HSA-169131 2.071689e-01 0.684 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.545321e-01 0.811 0 0
MTF1 activates gene expression R-HSA-5660489 1.545321e-01 0.811 0 0
Unwinding of DNA R-HSA-176974 1.647066e-01 0.783 0 0
Bicarbonate transporters R-HSA-425381 2.230573e-01 0.652 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.887401e-01 0.724 0 0
TNF signaling R-HSA-75893 2.150799e-01 0.667 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.466945e-01 0.834 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.696715e-01 0.770 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.875852e-01 0.727 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.161620e-01 0.665 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.230573e-01 0.652 0 0
Calmodulin induced events R-HSA-111933 2.362767e-01 0.627 0 0
Base Excision Repair R-HSA-73884 1.833215e-01 0.737 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.647066e-01 0.783 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.717460e-01 0.765 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.021457e-01 0.694 0 0
CaM pathway R-HSA-111997 2.362767e-01 0.627 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.379627e-01 0.623 0 0
Basigin interactions R-HSA-210991 1.875852e-01 0.727 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.668883e-01 0.778 0 0
Potential therapeutics for SARS R-HSA-9679191 1.290858e-01 0.889 0 0
Formation of definitive endoderm R-HSA-9823730 1.683493e-01 0.774 0 0
Hedgehog 'off' state R-HSA-5610787 1.554735e-01 0.808 0 0
Suppression of phagosomal maturation R-HSA-9637687 1.717460e-01 0.765 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.493945e-01 0.603 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.956779e-01 0.708 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.874173e-01 0.727 0 0
Downstream TCR signaling R-HSA-202424 1.833215e-01 0.737 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.875852e-01 0.727 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.717460e-01 0.765 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.684597e-01 0.774 0 0
Signal regulatory protein family interactions R-HSA-391160 1.592202e-01 0.798 0 0
Infectious disease R-HSA-5663205 1.503917e-01 0.823 0 0
RET signaling R-HSA-8853659 1.321338e-01 0.879 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.875852e-01 0.727 0 0
Syndecan interactions R-HSA-3000170 2.493945e-01 0.603 0 0
ABC-family proteins mediated transport R-HSA-382556 1.554735e-01 0.808 0 0
Activation of RAC1 R-HSA-428540 2.535996e-01 0.596 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.075645e-01 0.683 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.708095e-01 0.767 0 0
Growth hormone receptor signaling R-HSA-982772 2.493945e-01 0.603 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.230573e-01 0.652 0 0
FLT3 signaling in disease R-HSA-9682385 1.321338e-01 0.879 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.290465e-01 0.640 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.493945e-01 0.603 0 0
Regulation of BACH1 activity R-HSA-9708530 2.049123e-01 0.688 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.150799e-01 0.667 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.956779e-01 0.708 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.538395e-01 0.595 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.538395e-01 0.595 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.538395e-01 0.595 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.538395e-01 0.595 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.538395e-01 0.595 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.538395e-01 0.595 0 0
Specification of primordial germ cells R-HSA-9827857 2.538395e-01 0.595 0 0
Interleukin-1 family signaling R-HSA-446652 2.580938e-01 0.588 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.584954e-01 0.588 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.593026e-01 0.586 0 0
Proteasome assembly R-HSA-9907900 2.606915e-01 0.584 0 0
G1 Phase R-HSA-69236 2.606915e-01 0.584 0 0
Cyclin D associated events in G1 R-HSA-69231 2.606915e-01 0.584 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.709222e-01 0.567 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.710622e-01 0.567 0 0
Neurodegenerative Diseases R-HSA-8863678 2.710622e-01 0.567 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.710622e-01 0.567 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.710622e-01 0.567 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.710622e-01 0.567 0 0
Transcription of the HIV genome R-HSA-167172 2.726813e-01 0.564 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.726813e-01 0.564 0 0
DAG and IP3 signaling R-HSA-1489509 2.769256e-01 0.558 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.772541e-01 0.557 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.791440e-01 0.554 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.791440e-01 0.554 0 0
Mismatch Repair R-HSA-5358508 2.791440e-01 0.554 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.791440e-01 0.554 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.791440e-01 0.554 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.806434e-01 0.552 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.806434e-01 0.552 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.806434e-01 0.552 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.806434e-01 0.552 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.806434e-01 0.552 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.806434e-01 0.552 0 0
CREB phosphorylation R-HSA-199920 2.806434e-01 0.552 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.806434e-01 0.552 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.806434e-01 0.552 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.806434e-01 0.552 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.817406e-01 0.550 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.817406e-01 0.550 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.846790e-01 0.546 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.846790e-01 0.546 0 0
Polymerase switching R-HSA-69091 2.846790e-01 0.546 0 0
Leading Strand Synthesis R-HSA-69109 2.846790e-01 0.546 0 0
Disorders of Nervous System Development R-HSA-9697154 2.846790e-01 0.546 0 0
Pervasive developmental disorders R-HSA-9005895 2.846790e-01 0.546 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.846790e-01 0.546 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.887287e-01 0.540 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.887287e-01 0.540 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.931098e-01 0.533 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.934237e-01 0.533 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.940624e-01 0.532 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.940624e-01 0.532 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.940624e-01 0.532 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.940624e-01 0.532 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.940624e-01 0.532 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 2.940624e-01 0.532 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.940624e-01 0.532 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.940624e-01 0.532 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.940624e-01 0.532 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.940624e-01 0.532 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.940624e-01 0.532 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.940624e-01 0.532 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.940624e-01 0.532 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.940624e-01 0.532 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.940624e-01 0.532 0 0
Inhibition of membrane repair R-HSA-9635644 2.940624e-01 0.532 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.940624e-01 0.532 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.940624e-01 0.532 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.008249e-01 0.522 0 0
FOXO-mediated transcription R-HSA-9614085 3.009067e-01 0.522 0 0
G-protein beta:gamma signalling R-HSA-397795 3.015127e-01 0.521 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.015127e-01 0.521 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.015127e-01 0.521 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.048178e-01 0.516 0 0
HIV Transcription Elongation R-HSA-167169 3.067949e-01 0.513 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.067949e-01 0.513 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.067949e-01 0.513 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.067949e-01 0.513 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.101490e-01 0.508 0 0
Hedgehog 'on' state R-HSA-5632684 3.140017e-01 0.503 0 0
Myogenesis R-HSA-525793 3.154475e-01 0.501 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.160420e-01 0.500 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.160420e-01 0.500 0 0
Formation of axial mesoderm R-HSA-9796292 3.160420e-01 0.500 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.160420e-01 0.500 0 0
Interleukin-6 signaling R-HSA-1059683 3.160420e-01 0.500 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.231255e-01 0.491 0 0
SOS-mediated signalling R-HSA-112412 3.231255e-01 0.491 0 0
Disinhibition of SNARE formation R-HSA-114516 3.231255e-01 0.491 0 0
Recycling of eIF2:GDP R-HSA-72731 3.231255e-01 0.491 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.231255e-01 0.491 0 0
CHL1 interactions R-HSA-447041 3.231255e-01 0.491 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.231255e-01 0.491 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.231255e-01 0.491 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.231255e-01 0.491 0 0
NGF-stimulated transcription R-HSA-9031628 3.270646e-01 0.485 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.275258e-01 0.485 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.281012e-01 0.484 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.283170e-01 0.484 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.307247e-01 0.481 0 0
Packaging Of Telomere Ends R-HSA-171306 3.379879e-01 0.471 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.379879e-01 0.471 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.379879e-01 0.471 0 0
Signaling by NOTCH2 R-HSA-1980145 3.417256e-01 0.466 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.417256e-01 0.466 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.417256e-01 0.466 0 0
Ca2+ pathway R-HSA-4086398 3.423288e-01 0.466 0 0
Translation of Structural Proteins R-HSA-9683701 3.435183e-01 0.464 0 0
Removal of the Flap Intermediate R-HSA-69166 3.474587e-01 0.459 0 0
Lagging Strand Synthesis R-HSA-69186 3.567364e-01 0.448 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.567364e-01 0.448 0 0
PERK regulates gene expression R-HSA-381042 3.620438e-01 0.441 0 0
Ca-dependent events R-HSA-111996 3.620826e-01 0.441 0 0
Adaptive Immune System R-HSA-1280218 3.624026e-01 0.441 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.649404e-01 0.438 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.649404e-01 0.438 0 0
Adrenoceptors R-HSA-390696 3.649404e-01 0.438 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.649404e-01 0.438 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.649404e-01 0.438 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.666867e-01 0.436 0 0
Hemostasis R-HSA-109582 3.670179e-01 0.435 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.714370e-01 0.430 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.714370e-01 0.430 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.714370e-01 0.430 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.714370e-01 0.430 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 3.714370e-01 0.430 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.714370e-01 0.430 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.714370e-01 0.430 0 0
C6 deamination of adenosine R-HSA-75102 3.714370e-01 0.430 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.714370e-01 0.430 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.714370e-01 0.430 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.714370e-01 0.430 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.714370e-01 0.430 0 0
Extension of Telomeres R-HSA-180786 3.762057e-01 0.425 0 0
Erythropoietin activates RAS R-HSA-9027284 3.787238e-01 0.422 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.787238e-01 0.422 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.787238e-01 0.422 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.787238e-01 0.422 0 0
p38MAPK events R-HSA-171007 3.787238e-01 0.422 0 0
Formation of the anterior neural plate R-HSA-9823739 3.787238e-01 0.422 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.824244e-01 0.417 0 0
GPVI-mediated activation cascade R-HSA-114604 3.824244e-01 0.417 0 0
RUNX2 regulates bone development R-HSA-8941326 3.824244e-01 0.417 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.827327e-01 0.417 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.827327e-01 0.417 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.827327e-01 0.417 0 0
Assembly Of The HIV Virion R-HSA-175474 3.827327e-01 0.417 0 0
Signaling by Erythropoietin R-HSA-9006335 3.833430e-01 0.416 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.833430e-01 0.416 0 0
Gastrulation R-HSA-9758941 3.859797e-01 0.413 0 0
Signaling by FGFR R-HSA-190236 3.885300e-01 0.411 0 0
Toll-like Receptor Cascades R-HSA-168898 3.970799e-01 0.401 0 0
Cleavage of the damaged purine R-HSA-110331 4.028108e-01 0.395 0 0
Lipophagy R-HSA-9613354 4.057241e-01 0.392 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.057241e-01 0.392 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.057241e-01 0.392 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.057241e-01 0.392 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.057241e-01 0.392 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.057241e-01 0.392 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.057241e-01 0.392 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.057241e-01 0.392 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.057241e-01 0.392 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.057241e-01 0.392 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.060008e-01 0.391 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.060008e-01 0.391 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.060008e-01 0.391 0 0
FGFR2 alternative splicing R-HSA-6803529 4.086027e-01 0.389 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.086027e-01 0.389 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.086027e-01 0.389 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.086426e-01 0.389 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.096561e-01 0.388 0 0
Killing mechanisms R-HSA-9664420 4.096561e-01 0.388 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.096561e-01 0.388 0 0
ABC transporter disorders R-HSA-5619084 4.146541e-01 0.382 0 0
Somitogenesis R-HSA-9824272 4.180502e-01 0.379 0 0
Depurination R-HSA-73927 4.231491e-01 0.374 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.239065e-01 0.373 0 0
Budding and maturation of HIV virion R-HSA-162588 4.285480e-01 0.368 0 0
Sensory processing of sound R-HSA-9659379 4.292124e-01 0.367 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.342447e-01 0.362 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.349225e-01 0.362 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.366566e-01 0.360 0 0
Signaling by TGFBR3 R-HSA-9839373 4.366566e-01 0.360 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.366566e-01 0.360 0 0
Signaling by Hedgehog R-HSA-5358351 4.368256e-01 0.360 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.400983e-01 0.356 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.400983e-01 0.356 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.400983e-01 0.356 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.400983e-01 0.356 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.403349e-01 0.356 0 0
Axonal growth stimulation R-HSA-209563 4.403349e-01 0.356 0 0
MET activates PTPN11 R-HSA-8865999 4.403349e-01 0.356 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.403349e-01 0.356 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.403349e-01 0.356 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.403349e-01 0.356 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.403349e-01 0.356 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.403349e-01 0.356 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.403349e-01 0.356 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.403349e-01 0.356 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.433881e-01 0.353 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.433881e-01 0.353 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.433881e-01 0.353 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.434399e-01 0.353 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.452006e-01 0.351 0 0
PI3K/AKT activation R-HSA-198203 4.452006e-01 0.351 0 0
Interleukin-27 signaling R-HSA-9020956 4.452006e-01 0.351 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.452006e-01 0.351 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.452006e-01 0.351 0 0
Signaling by Leptin R-HSA-2586552 4.452006e-01 0.351 0 0
Ion channel transport R-HSA-983712 4.575611e-01 0.340 1 0
Amyloid fiber formation R-HSA-977225 4.582634e-01 0.339 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.595668e-01 0.338 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.634795e-01 0.334 0 0
Diseases of Immune System R-HSA-5260271 4.634795e-01 0.334 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.699153e-01 0.328 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.699153e-01 0.328 0 0
Inositol phosphate metabolism R-HSA-1483249 4.712064e-01 0.327 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.730487e-01 0.325 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.779661e-01 0.321 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.779661e-01 0.321 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.831665e-01 0.316 0 0
Formation of the posterior neural plate R-HSA-9832991 4.831665e-01 0.316 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.831665e-01 0.316 0 0
Suppression of apoptosis R-HSA-9635465 4.831665e-01 0.316 0 0
Interleukin-2 signaling R-HSA-9020558 4.831665e-01 0.316 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.833781e-01 0.316 0 0
TGFBR3 expression R-HSA-9839394 4.844867e-01 0.315 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.844867e-01 0.315 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.844867e-01 0.315 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.871030e-01 0.312 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.917846e-01 0.308 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.948835e-01 0.305 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.956645e-01 0.305 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.989936e-01 0.302 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.989936e-01 0.302 0 0
Platelet sensitization by LDL R-HSA-432142 4.989936e-01 0.302 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.989936e-01 0.302 0 0
Apoptotic factor-mediated response R-HSA-111471 4.989936e-01 0.302 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.016844e-01 0.300 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.016844e-01 0.300 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.016844e-01 0.300 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.016844e-01 0.300 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.016844e-01 0.300 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.016844e-01 0.300 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.016844e-01 0.300 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.016844e-01 0.300 0 0
Dopamine receptors R-HSA-390651 5.016844e-01 0.300 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.016844e-01 0.300 0 0
Transmission across Electrical Synapses R-HSA-112307 5.016844e-01 0.300 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.016844e-01 0.300 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.016844e-01 0.300 0 0
Interleukin-38 signaling R-HSA-9007892 5.016844e-01 0.300 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.030421e-01 0.298 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.030421e-01 0.298 0 0
MET activates PTK2 signaling R-HSA-8874081 5.089316e-01 0.293 0 0
Signal amplification R-HSA-392518 5.163712e-01 0.287 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.194787e-01 0.284 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.194787e-01 0.284 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.194787e-01 0.284 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.194787e-01 0.284 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.194787e-01 0.284 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.194787e-01 0.284 0 0
Sodium/Calcium exchangers R-HSA-425561 5.194787e-01 0.284 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.199185e-01 0.284 0 0
Regulated Necrosis R-HSA-5218859 5.207957e-01 0.283 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.224329e-01 0.282 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.224329e-01 0.282 0 0
Depyrimidination R-HSA-73928 5.224329e-01 0.282 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.237824e-01 0.281 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.272392e-01 0.278 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.272392e-01 0.278 0 0
The NLRP3 inflammasome R-HSA-844456 5.272392e-01 0.278 0 0
Maturation of nucleoprotein R-HSA-9694631 5.272392e-01 0.278 0 0
Other interleukin signaling R-HSA-449836 5.272392e-01 0.278 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.272392e-01 0.278 0 0
Stimuli-sensing channels R-HSA-2672351 5.282547e-01 0.277 1 1
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.328381e-01 0.273 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.328381e-01 0.273 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.328381e-01 0.273 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.328381e-01 0.273 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.328381e-01 0.273 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.363202e-01 0.271 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.374655e-01 0.270 0 0
G alpha (12/13) signalling events R-HSA-416482 5.400980e-01 0.268 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.451687e-01 0.263 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.468694e-01 0.262 0 0
PLC beta mediated events R-HSA-112043 5.485281e-01 0.261 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.540437e-01 0.256 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.540437e-01 0.256 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.540437e-01 0.256 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.540437e-01 0.256 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.540437e-01 0.256 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.540437e-01 0.256 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.540437e-01 0.256 0 0
Interleukin-35 Signalling R-HSA-8984722 5.540437e-01 0.256 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.540437e-01 0.256 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.540437e-01 0.256 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.545766e-01 0.256 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.545766e-01 0.256 0 0
Telomere Extension By Telomerase R-HSA-171319 5.561513e-01 0.255 0 0
Insulin receptor recycling R-HSA-77387 5.561513e-01 0.255 0 0
Pyroptosis R-HSA-5620971 5.561513e-01 0.255 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.561513e-01 0.255 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.561513e-01 0.255 0 0
G2 Phase R-HSA-68911 5.563121e-01 0.255 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.563121e-01 0.255 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.563121e-01 0.255 0 0
Defective F9 activation R-HSA-9673221 5.563121e-01 0.255 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.563121e-01 0.255 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.563121e-01 0.255 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.563121e-01 0.255 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.563121e-01 0.255 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.563121e-01 0.255 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.563121e-01 0.255 0 0
Inositol transporters R-HSA-429593 5.563121e-01 0.255 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.563121e-01 0.255 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.563121e-01 0.255 0 0
Co-inhibition by BTLA R-HSA-9927353 5.563121e-01 0.255 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.563121e-01 0.255 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.563121e-01 0.255 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.563121e-01 0.255 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.563121e-01 0.255 0 0
Pyruvate metabolism R-HSA-70268 5.573837e-01 0.254 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.583009e-01 0.253 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.583009e-01 0.253 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.583009e-01 0.253 0 0
Opioid Signalling R-HSA-111885 5.750569e-01 0.240 0 0
Interferon gamma signaling R-HSA-877300 5.780044e-01 0.238 0 0
Glucagon-type ligand receptors R-HSA-420092 5.788251e-01 0.237 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.794072e-01 0.237 0 0
G-protein activation R-HSA-202040 5.809466e-01 0.236 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.809466e-01 0.236 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.809466e-01 0.236 0 0
ERK/MAPK targets R-HSA-198753 5.809466e-01 0.236 0 0
Signalling to RAS R-HSA-167044 5.809466e-01 0.236 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.816971e-01 0.235 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.868080e-01 0.232 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.868080e-01 0.232 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.868080e-01 0.232 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.868080e-01 0.232 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.868080e-01 0.232 0 0
Maturation of nucleoprotein R-HSA-9683610 5.868080e-01 0.232 0 0
RSV-host interactions R-HSA-9833110 5.873967e-01 0.231 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.888963e-01 0.230 0 0
Ion transport by P-type ATPases R-HSA-936837 5.960307e-01 0.225 0 0
G alpha (z) signalling events R-HSA-418597 5.960506e-01 0.225 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.980032e-01 0.223 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.980032e-01 0.223 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.008215e-01 0.221 0 0
Interleukin-37 signaling R-HSA-9008059 6.008215e-01 0.221 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.049541e-01 0.218 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.049541e-01 0.218 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.049541e-01 0.218 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.049541e-01 0.218 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.049541e-01 0.218 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.049541e-01 0.218 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.049541e-01 0.218 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.049541e-01 0.218 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.049541e-01 0.218 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.049541e-01 0.218 0 0
Ceramide signalling R-HSA-193681 6.049541e-01 0.218 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.049541e-01 0.218 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.049541e-01 0.218 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.049541e-01 0.218 0 0
Signaling by MST1 R-HSA-8852405 6.049541e-01 0.218 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.049541e-01 0.218 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.049541e-01 0.218 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.049541e-01 0.218 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.049541e-01 0.218 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.063050e-01 0.217 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.063050e-01 0.217 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.063050e-01 0.217 0 0
Ribavirin ADME R-HSA-9755088 6.063050e-01 0.217 0 0
Serine metabolism R-HSA-977347 6.063050e-01 0.217 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.107742e-01 0.214 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.111101e-01 0.214 0 0
Platelet homeostasis R-HSA-418346 6.116024e-01 0.214 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.123508e-01 0.213 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.137061e-01 0.212 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.141659e-01 0.212 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.177512e-01 0.209 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.177512e-01 0.209 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.177512e-01 0.209 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.177512e-01 0.209 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.177512e-01 0.209 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.177512e-01 0.209 0 0
Malate-aspartate shuttle R-HSA-9856872 6.177512e-01 0.209 0 0
Downstream signal transduction R-HSA-186763 6.221096e-01 0.206 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.306211e-01 0.200 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.306211e-01 0.200 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.306211e-01 0.200 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.306211e-01 0.200 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.306211e-01 0.200 0 0
GPER1 signaling R-HSA-9634597 6.312895e-01 0.200 0 0
Intraflagellar transport R-HSA-5620924 6.312895e-01 0.200 0 0
Innate Immune System R-HSA-168249 6.328233e-01 0.199 0 0
G-protein mediated events R-HSA-112040 6.409258e-01 0.193 0 0
HCMV Late Events R-HSA-9610379 6.454695e-01 0.190 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.460023e-01 0.190 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.468786e-01 0.189 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.468786e-01 0.189 0 0
Biotin transport and metabolism R-HSA-196780 6.468786e-01 0.189 0 0
DNA Damage Reversal R-HSA-73942 6.468786e-01 0.189 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.474743e-01 0.189 0 0
Signaling by LTK in cancer R-HSA-9842640 6.482660e-01 0.188 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.482660e-01 0.188 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.482660e-01 0.188 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.482660e-01 0.188 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.482660e-01 0.188 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.482660e-01 0.188 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.482660e-01 0.188 0 0
MET Receptor Activation R-HSA-6806942 6.482660e-01 0.188 0 0
VLDL assembly R-HSA-8866423 6.482660e-01 0.188 0 0
HDL clearance R-HSA-8964011 6.482660e-01 0.188 0 0
Translation of Structural Proteins R-HSA-9694635 6.524109e-01 0.185 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.538759e-01 0.185 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.538759e-01 0.185 0 0
Peroxisomal protein import R-HSA-9033241 6.590348e-01 0.181 0 0
Regulation of beta-cell development R-HSA-186712 6.590348e-01 0.181 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.624728e-01 0.179 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.624728e-01 0.179 0 0
Cardiogenesis R-HSA-9733709 6.624728e-01 0.179 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.640515e-01 0.178 0 0
Integrin cell surface interactions R-HSA-216083 6.657066e-01 0.177 0 0
tRNA Aminoacylation R-HSA-379724 6.738153e-01 0.171 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.742165e-01 0.171 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.742165e-01 0.171 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.742165e-01 0.171 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.742165e-01 0.171 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.742165e-01 0.171 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.742165e-01 0.171 0 0
Virus Assembly and Release R-HSA-168268 6.742165e-01 0.171 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.760608e-01 0.170 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.760608e-01 0.170 0 0
Interleukin-6 family signaling R-HSA-6783589 6.760608e-01 0.170 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.815192e-01 0.167 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.868315e-01 0.163 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.868315e-01 0.163 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.868315e-01 0.163 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.868315e-01 0.163 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.868315e-01 0.163 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.868315e-01 0.163 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.868315e-01 0.163 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.868315e-01 0.163 0 0
VLDL clearance R-HSA-8964046 6.868315e-01 0.163 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.868315e-01 0.163 0 0
LDL remodeling R-HSA-8964041 6.868315e-01 0.163 0 0
Netrin mediated repulsion signals R-HSA-418886 6.868315e-01 0.163 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.868315e-01 0.163 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.868315e-01 0.163 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.881476e-01 0.162 0 0
Protein localization R-HSA-9609507 6.924131e-01 0.160 0 0
Neurexins and neuroligins R-HSA-6794361 6.951330e-01 0.158 0 0
G protein gated Potassium channels R-HSA-1296059 6.971762e-01 0.157 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.971762e-01 0.157 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.971762e-01 0.157 0 0
Tight junction interactions R-HSA-420029 6.971762e-01 0.157 0 0
Laminin interactions R-HSA-3000157 6.971762e-01 0.157 0 0
Hyaluronan degradation R-HSA-2160916 6.971762e-01 0.157 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.971762e-01 0.157 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.997987e-01 0.155 0 0
Hyaluronan metabolism R-HSA-2142845 6.997987e-01 0.155 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.998071e-01 0.155 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.998071e-01 0.155 0 0
Glycine degradation R-HSA-6783984 6.998071e-01 0.155 0 0
Fibronectin matrix formation R-HSA-1566977 6.998071e-01 0.155 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.998071e-01 0.155 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.998071e-01 0.155 0 0
Response to metal ions R-HSA-5660526 6.998071e-01 0.155 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.172304e-01 0.144 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.172304e-01 0.144 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.172304e-01 0.144 0 0
TRP channels R-HSA-3295583 7.172304e-01 0.144 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.172304e-01 0.144 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.172304e-01 0.144 0 0
Netrin-1 signaling R-HSA-373752 7.200889e-01 0.143 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.211705e-01 0.142 0 0
MET receptor recycling R-HSA-8875656 7.211705e-01 0.142 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.211705e-01 0.142 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.211705e-01 0.142 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.211705e-01 0.142 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.211705e-01 0.142 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.211705e-01 0.142 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.211705e-01 0.142 0 0
Fructose biosynthesis R-HSA-5652227 7.211705e-01 0.142 0 0
Interleukin-9 signaling R-HSA-8985947 7.211705e-01 0.142 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.211705e-01 0.142 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.211705e-01 0.142 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.211705e-01 0.142 0 0
Alpha-defensins R-HSA-1462054 7.211705e-01 0.142 0 0
Sodium/Proton exchangers R-HSA-425986 7.211705e-01 0.142 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.211705e-01 0.142 0 0
Interleukin-23 signaling R-HSA-9020933 7.211705e-01 0.142 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.237047e-01 0.140 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.237047e-01 0.140 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.237047e-01 0.140 0 0
Adipogenesis R-HSA-9843745 7.251769e-01 0.140 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.279352e-01 0.138 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.305321e-01 0.136 0 0
Signaling by FGFR in disease R-HSA-1226099 7.337963e-01 0.134 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.351564e-01 0.134 0 0
Cristae formation R-HSA-8949613 7.362381e-01 0.133 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.362381e-01 0.133 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.440484e-01 0.128 0 0
Nephron development R-HSA-9831926 7.459730e-01 0.127 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.459730e-01 0.127 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.499748e-01 0.125 0 0
NRAGE signals death through JNK R-HSA-193648 7.511557e-01 0.124 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.517461e-01 0.124 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.517461e-01 0.124 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.517461e-01 0.124 0 0
Interleukin-21 signaling R-HSA-9020958 7.517461e-01 0.124 0 0
mRNA Editing R-HSA-75072 7.517461e-01 0.124 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.517461e-01 0.124 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.517461e-01 0.124 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.517461e-01 0.124 0 0
Interleukin-1 processing R-HSA-448706 7.517461e-01 0.124 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.517461e-01 0.124 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.517461e-01 0.124 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.542198e-01 0.123 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.542198e-01 0.123 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.542198e-01 0.123 0 0
Inflammasomes R-HSA-622312 7.542198e-01 0.123 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.542198e-01 0.123 0 0
Dectin-2 family R-HSA-5621480 7.639217e-01 0.117 0 0
tRNA processing R-HSA-72306 7.649294e-01 0.116 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.652839e-01 0.116 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.666818e-01 0.115 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.666818e-01 0.115 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.666818e-01 0.115 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.666818e-01 0.115 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.666818e-01 0.115 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.666818e-01 0.115 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.712004e-01 0.113 0 0
DARPP-32 events R-HSA-180024 7.712004e-01 0.113 0 0
OADH complex synthesizes glutaryl-CoA from 2-OA R-HSA-9858328 7.789704e-01 0.108 0 0
Binding and entry of HIV virion R-HSA-173107 7.789704e-01 0.108 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.789704e-01 0.108 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.789704e-01 0.108 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.789704e-01 0.108 0 0
DNA replication initiation R-HSA-68952 7.789704e-01 0.108 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.789704e-01 0.108 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.789704e-01 0.108 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.789704e-01 0.108 0 0
Formation of apoptosome R-HSA-111458 7.789704e-01 0.108 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.789704e-01 0.108 0 0
Maturation of spike protein R-HSA-9683686 7.789704e-01 0.108 0 0
Disease R-HSA-1643685 7.792644e-01 0.108 0 0
Pentose phosphate pathway R-HSA-71336 7.797879e-01 0.108 0 0
RAS processing R-HSA-9648002 7.797879e-01 0.108 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.859053e-01 0.105 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.859053e-01 0.105 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.859053e-01 0.105 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.859053e-01 0.105 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.859053e-01 0.105 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.859053e-01 0.105 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.859053e-01 0.105 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.859053e-01 0.105 0 0
Creatine metabolism R-HSA-71288 7.859053e-01 0.105 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.872085e-01 0.104 0 0
DAP12 signaling R-HSA-2424491 7.872085e-01 0.104 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.872085e-01 0.104 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.935719e-01 0.100 0 0
Interleukin-2 family signaling R-HSA-451927 7.935719e-01 0.100 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.984830e-01 0.098 0 0
Metabolism of polyamines R-HSA-351202 7.992946e-01 0.097 0 0
Neddylation R-HSA-8951664 8.006723e-01 0.097 0 0
Azathioprine ADME R-HSA-9748787 8.016081e-01 0.096 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.022759e-01 0.096 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.032106e-01 0.095 0 0
Signaling by APC mutants R-HSA-4839744 8.032106e-01 0.095 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.032106e-01 0.095 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.032106e-01 0.095 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.032106e-01 0.095 0 0
LGI-ADAM interactions R-HSA-5682910 8.032106e-01 0.095 0 0
vRNA Synthesis R-HSA-192814 8.032106e-01 0.095 0 0
vRNP Assembly R-HSA-192905 8.032106e-01 0.095 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.032106e-01 0.095 0 0
Chylomicron assembly R-HSA-8963888 8.032106e-01 0.095 0 0
Synthesis of PI R-HSA-1483226 8.032106e-01 0.095 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.032106e-01 0.095 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.032106e-01 0.095 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.037202e-01 0.095 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.037202e-01 0.095 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.037202e-01 0.095 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.037202e-01 0.095 0 0
Regulation of insulin secretion R-HSA-422356 8.107966e-01 0.091 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.164363e-01 0.088 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.164363e-01 0.088 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.190514e-01 0.087 0 0
HIV Transcription Initiation R-HSA-167161 8.190514e-01 0.087 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.190514e-01 0.087 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.190514e-01 0.087 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.202042e-01 0.086 0 0
Mitochondrial protein import R-HSA-1268020 8.205050e-01 0.086 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.205050e-01 0.086 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.205050e-01 0.086 0 0
Heme signaling R-HSA-9707616 8.205050e-01 0.086 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.247937e-01 0.084 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.247937e-01 0.084 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.247937e-01 0.084 0 0
Plasmalogen biosynthesis R-HSA-75896 8.247937e-01 0.084 0 0
Signaling by AXIN mutants R-HSA-4839735 8.247937e-01 0.084 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.247937e-01 0.084 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.247937e-01 0.084 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.269621e-01 0.083 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.280484e-01 0.082 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.297254e-01 0.081 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.346957e-01 0.078 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.349562e-01 0.078 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.354347e-01 0.078 0 0
Fructose metabolism R-HSA-5652084 8.354347e-01 0.078 0 0
LDL clearance R-HSA-8964038 8.354347e-01 0.078 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.354347e-01 0.078 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.411586e-01 0.075 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.418810e-01 0.075 0 0
TBC/RABGAPs R-HSA-8854214 8.418810e-01 0.075 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.421798e-01 0.075 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.440108e-01 0.074 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.440108e-01 0.074 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.440108e-01 0.074 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.440108e-01 0.074 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.440108e-01 0.074 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.440108e-01 0.074 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.440108e-01 0.074 0 0
Signaling by LTK R-HSA-9842663 8.440108e-01 0.074 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.440108e-01 0.074 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.440108e-01 0.074 0 0
OAS antiviral response R-HSA-8983711 8.440108e-01 0.074 0 0
Integration of energy metabolism R-HSA-163685 8.458930e-01 0.073 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.494885e-01 0.071 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.494885e-01 0.071 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.494885e-01 0.071 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.494885e-01 0.071 0 0
Biosynthesis of maresins R-HSA-9018682 8.494885e-01 0.071 0 0
Interleukin-20 family signaling R-HSA-8854691 8.494885e-01 0.071 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.538370e-01 0.069 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.538370e-01 0.069 0 0
eNOS activation R-HSA-203615 8.538370e-01 0.069 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.538370e-01 0.069 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.538370e-01 0.069 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.592539e-01 0.066 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.611211e-01 0.065 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.611211e-01 0.065 0 0
Processing of SMDT1 R-HSA-8949664 8.611211e-01 0.065 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.611211e-01 0.065 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.611211e-01 0.065 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.611211e-01 0.065 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.611211e-01 0.065 0 0
SLC transporter disorders R-HSA-5619102 8.616571e-01 0.065 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.618301e-01 0.065 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.622378e-01 0.064 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.622378e-01 0.064 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.624404e-01 0.064 0 0
Complex III assembly R-HSA-9865881 8.624404e-01 0.064 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.647346e-01 0.063 0 0
Cardiac conduction R-HSA-5576891 8.691956e-01 0.061 0 0
Parasite infection R-HSA-9664407 8.695972e-01 0.061 0 0
Leishmania phagocytosis R-HSA-9664417 8.695972e-01 0.061 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.695972e-01 0.061 0 0
Diseases of DNA repair R-HSA-9675135 8.715470e-01 0.060 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.715470e-01 0.060 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.743629e-01 0.058 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.743629e-01 0.058 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.743629e-01 0.058 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.743629e-01 0.058 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.743629e-01 0.058 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.750506e-01 0.058 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.763555e-01 0.057 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 8.763555e-01 0.057 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 8.763555e-01 0.057 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 8.763555e-01 0.057 0 0
Physiological factors R-HSA-5578768 8.763555e-01 0.057 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.763555e-01 0.057 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.763555e-01 0.057 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.797052e-01 0.056 0 0
Transmission across Chemical Synapses R-HSA-112315 8.815327e-01 0.055 0 0
Voltage gated Potassium channels R-HSA-1296072 8.844009e-01 0.053 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.853260e-01 0.053 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.853260e-01 0.053 0 0
Urea cycle R-HSA-70635 8.853260e-01 0.053 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.899195e-01 0.051 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.899195e-01 0.051 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.899195e-01 0.051 0 0
Protein lipoylation R-HSA-9857492 8.899195e-01 0.051 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.899195e-01 0.051 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.899195e-01 0.051 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.899195e-01 0.051 0 0
Other semaphorin interactions R-HSA-416700 8.899195e-01 0.051 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.932436e-01 0.049 0 0
Elastic fibre formation R-HSA-1566948 8.932436e-01 0.049 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.945386e-01 0.048 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.953967e-01 0.048 0 0
Insulin processing R-HSA-264876 8.953967e-01 0.048 0 0
Metabolism of proteins R-HSA-392499 8.974788e-01 0.047 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.013436e-01 0.045 0 0
Aquaporin-mediated transport R-HSA-445717 9.013436e-01 0.045 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.019962e-01 0.045 0 0
Atorvastatin ADME R-HSA-9754706 9.019962e-01 0.045 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.019962e-01 0.045 0 0
Fructose catabolism R-HSA-70350 9.019962e-01 0.045 0 0
Differentiation of T cells R-HSA-9945266 9.019962e-01 0.045 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.019962e-01 0.045 0 0
Carnitine synthesis R-HSA-71262 9.019962e-01 0.045 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.019962e-01 0.045 0 0
Attachment and Entry R-HSA-9678110 9.019962e-01 0.045 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.035440e-01 0.044 0 0
PI3K Cascade R-HSA-109704 9.035440e-01 0.044 0 0
Signaling by Insulin receptor R-HSA-74752 9.039237e-01 0.044 0 0
Signaling by PDGF R-HSA-186797 9.077634e-01 0.042 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.091272e-01 0.041 0 0
The phototransduction cascade R-HSA-2514856 9.103512e-01 0.041 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.127487e-01 0.040 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.127487e-01 0.040 0 0
Passive transport by Aquaporins R-HSA-432047 9.127487e-01 0.040 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.127487e-01 0.040 0 0
Synthesis of PG R-HSA-1483148 9.127487e-01 0.040 0 0
Galactose catabolism R-HSA-70370 9.127487e-01 0.040 0 0
Coenzyme A biosynthesis R-HSA-196783 9.127487e-01 0.040 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.127487e-01 0.040 0 0
mRNA Capping R-HSA-72086 9.131127e-01 0.039 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.131127e-01 0.039 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.162369e-01 0.038 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.167274e-01 0.038 0 0
Insulin receptor signalling cascade R-HSA-74751 9.195140e-01 0.036 0 0
IGF1R signaling cascade R-HSA-2428924 9.195140e-01 0.036 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.208758e-01 0.036 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.223220e-01 0.035 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.223220e-01 0.035 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.223220e-01 0.035 0 0
Choline catabolism R-HSA-6798163 9.223220e-01 0.035 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.223220e-01 0.035 0 0
Nucleotide biosynthesis R-HSA-8956320 9.226949e-01 0.035 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.228358e-01 0.035 0 0
Formation of the cornified envelope R-HSA-6809371 9.240569e-01 0.034 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.248776e-01 0.034 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.279251e-01 0.032 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.279820e-01 0.032 0 0
Activation of GABAB receptors R-HSA-991365 9.289554e-01 0.032 0 0
GABA B receptor activation R-HSA-977444 9.289554e-01 0.032 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.289554e-01 0.032 0 0
Leishmania infection R-HSA-9658195 9.299531e-01 0.032 0 0
Parasitic Infection Pathways R-HSA-9824443 9.299531e-01 0.032 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.308454e-01 0.031 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.308454e-01 0.031 0 0
PKA activation R-HSA-163615 9.308454e-01 0.031 0 0
PKA activation in glucagon signalling R-HSA-164378 9.308454e-01 0.031 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.308454e-01 0.031 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.308454e-01 0.031 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.308454e-01 0.031 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.326511e-01 0.030 0 0
Paracetamol ADME R-HSA-9753281 9.334896e-01 0.030 0 0
Signaling by WNT in cancer R-HSA-4791275 9.344820e-01 0.029 0 0
Mitochondrial biogenesis R-HSA-1592230 9.372632e-01 0.028 0 0
Pyrimidine biosynthesis R-HSA-500753 9.384340e-01 0.028 0 0
Specification of the neural plate border R-HSA-9834899 9.384340e-01 0.028 0 0
Conjugation of carboxylic acids R-HSA-159424 9.384340e-01 0.028 0 0
Amino Acid conjugation R-HSA-156587 9.384340e-01 0.028 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.384340e-01 0.028 0 0
Methionine salvage pathway R-HSA-1237112 9.384340e-01 0.028 0 0
Diseases of hemostasis R-HSA-9671793 9.384340e-01 0.028 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.384340e-01 0.028 0 0
DAP12 interactions R-HSA-2172127 9.398759e-01 0.027 0 0
Amine ligand-binding receptors R-HSA-375280 9.398759e-01 0.027 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.404232e-01 0.027 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.404232e-01 0.027 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.421896e-01 0.026 0 0
IRS-mediated signalling R-HSA-112399 9.428999e-01 0.026 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.448789e-01 0.025 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.451903e-01 0.024 0 0
Signaling by NODAL R-HSA-1181150 9.451903e-01 0.024 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.451903e-01 0.024 0 0
Pregnenolone biosynthesis R-HSA-196108 9.451903e-01 0.024 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.458499e-01 0.024 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.458499e-01 0.024 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.458499e-01 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.492235e-01 0.023 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.492235e-01 0.023 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.495501e-01 0.022 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.497993e-01 0.022 0 0
Post-translational protein modification R-HSA-597592 9.498722e-01 0.022 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.508034e-01 0.022 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.512055e-01 0.022 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.512055e-01 0.022 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.512055e-01 0.022 0 0
Phenylalanine metabolism R-HSA-8964208 9.512055e-01 0.022 0 0
Abacavir metabolism R-HSA-2161541 9.512055e-01 0.022 0 0
Extracellular matrix organization R-HSA-1474244 9.525321e-01 0.021 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.535072e-01 0.021 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.537225e-01 0.021 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.553224e-01 0.020 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.553224e-01 0.020 0 0
Mitochondrial protein degradation R-HSA-9837999 9.564319e-01 0.019 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.565608e-01 0.019 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.565608e-01 0.019 0 0
Glutathione synthesis and recycling R-HSA-174403 9.565608e-01 0.019 0 0
Attachment and Entry R-HSA-9694614 9.565608e-01 0.019 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.567859e-01 0.019 0 0
Metal ion SLC transporters R-HSA-425410 9.572017e-01 0.019 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.594423e-01 0.018 0 0
Triglyceride catabolism R-HSA-163560 9.594423e-01 0.018 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.594423e-01 0.018 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.613287e-01 0.017 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.613287e-01 0.017 0 0
Ethanol oxidation R-HSA-71384 9.613287e-01 0.017 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.613287e-01 0.017 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.631964e-01 0.016 0 0
Metabolism of folate and pterines R-HSA-196757 9.631964e-01 0.016 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.634642e-01 0.016 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.655735e-01 0.015 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.655735e-01 0.015 0 0
Formation of the ureteric bud R-HSA-9830674 9.655735e-01 0.015 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.655735e-01 0.015 0 0
Carnitine shuttle R-HSA-200425 9.655735e-01 0.015 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.655735e-01 0.015 0 0
CYP2E1 reactions R-HSA-211999 9.693526e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.693526e-01 0.014 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.693526e-01 0.014 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.693526e-01 0.014 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.697274e-01 0.013 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.716916e-01 0.012 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.727170e-01 0.012 0 0
Formation of the nephric duct R-HSA-9830364 9.727170e-01 0.012 0 0
Kidney development R-HSA-9830369 9.741281e-01 0.011 0 0
Maturation of spike protein R-HSA-9694548 9.751336e-01 0.011 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.757123e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.757123e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.757123e-01 0.011 0 0
PI Metabolism R-HSA-1483255 9.761629e-01 0.010 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.762384e-01 0.010 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.762384e-01 0.010 0 0
Neuronal System R-HSA-112316 9.765382e-01 0.010 0 0
Intra-Golgi traffic R-HSA-6811438 9.774740e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.783789e-01 0.009 0 0
FCGR activation R-HSA-2029481 9.793649e-01 0.009 0 0
COPII-mediated vesicle transport R-HSA-204005 9.797675e-01 0.009 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.797675e-01 0.009 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.807529e-01 0.008 0 0
Pyrimidine salvage R-HSA-73614 9.807529e-01 0.008 0 0
Prednisone ADME R-HSA-9757110 9.807529e-01 0.008 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.821476e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.822558e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.828663e-01 0.008 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.828663e-01 0.008 0 0
Methylation R-HSA-156581 9.832847e-01 0.007 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.837853e-01 0.007 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.841702e-01 0.007 0 0
Aspirin ADME R-HSA-9749641 9.842320e-01 0.007 0 0
Rab regulation of trafficking R-HSA-9007101 9.843162e-01 0.007 0 0
Potassium Channels R-HSA-1296071 9.846350e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.847478e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.847478e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.851881e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.864227e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.876278e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.888142e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.892413e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.892413e-01 0.005 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.893533e-01 0.005 0 0
Xenobiotics R-HSA-211981 9.897200e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.898893e-01 0.004 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.898893e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.899413e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.904230e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.904230e-01 0.004 0 0
Heme degradation R-HSA-189483 9.904230e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.914517e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.914750e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.914750e-01 0.004 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.917454e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.917454e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.921765e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.924114e-01 0.003 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.924114e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.924114e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.928386e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.928981e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.929000e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.932451e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.939872e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.939872e-01 0.003 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.939872e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.939872e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.946478e-01 0.002 0 0
Purine salvage R-HSA-74217 9.946478e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.957594e-01 0.002 0 0
Metabolism of nucleotides R-HSA-15869 9.957720e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.959581e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.962254e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.963639e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.966402e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.966783e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.967209e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.967209e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.972318e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.972374e-01 0.001 0 0
Defensins R-HSA-1461973 9.973381e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.973381e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.976307e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.976472e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.978350e-01 0.001 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.978911e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.982334e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.985743e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.988220e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.989594e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.989594e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.990633e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.991540e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.992432e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993174e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.994145e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.995032e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.995032e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996326e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.996388e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996448e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996731e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996731e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996731e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997410e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997493e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998096e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998376e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998855e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998981e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998981e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.998995e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999006e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999214e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999269e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999290e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999469e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999599e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999599e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999622e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999713e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999774e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999776e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999905e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999918e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999936e-01 0.000 1 0
Visual phototransduction R-HSA-2187338 9.999938e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999951e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999959e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999961e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999964e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999967e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999969e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999980e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999983e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999992e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999993e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999995e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999997e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways