RIPK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43353 S174 EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 LDNEFHVKIADFGLsKWRMMsLsQsRssKSAPEGGTIIYMP
O43353 S176 GPS6|SIGNOR|EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 NEFHVKIADFGLsKWRMMsLsQsRssKSAPEGGTIIYMPPE
O43353 S178 EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 FHVKIADFGLsKWRMMsLsQsRssKSAPEGGTIIYMPPENY
O43353 S180 EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 VKIADFGLsKWRMMsLsQsRssKSAPEGGTIIYMPPENYEP
O43353 S181 EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 KIADFGLsKWRMMsLsQsRssKSAPEGGTIIYMPPENYEPG
O43353 S25 Sugiyama RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 AICSALPTIPYHKLADLRYLsRGAsGTVSSARHADWRVQVA
O43353 S29 Sugiyama RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 ALPTIPYHKLADLRYLsRGAsGTVSSARHADWRVQVAVKHL
O43353 T53 Sugiyama RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 SSARHADWRVQVAVKHLHIHtPLLDSERKDVLREAEILHKA
O43353 Y474 EPSD|PSP RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 ACLNQSLDALLSRDLIMKEDyELVSTKPtRtsKVRQLLDTT
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95292 S160 Sugiyama VAPB UNQ484/PRO983 IIstTAsKtEtPIVSKsLsssLDDtEVKKVMEECKRLQGEV
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17535 S315 Sugiyama JUND RLEEKVKTLKSQNTELASTAsLLREQVAQLKQKVLSHVNSG
P23526 T157 Sugiyama AHCY SAHH NLIHTKYPQLLPGIRGIsEEtTTGVHNLyKMMANGILKVPA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P31949 T33 Sugiyama S100A11 MLN70 S100C CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 S230 Sugiyama RPL5 MSTP030 yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q13568 S435 SIGNOR IRF5 TVQVVPVAARLLLEMFSGELsWsADsIRLQIsNPDLKDRMV
Q13568 S446 SIGNOR IRF5 LLEMFSGELsWsADsIRLQIsNPDLKDRMVEQFKELHHIWQ
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q96ST3 S158 Sugiyama SIN3A GSQPQVYNDFLDIMKEFKSQsIDtPGVISRVSQLFKGHPDL
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9Y2B0 T79 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 2.770048e-10 9.558 1 0
Nuclear Receptor transcription pathway R-HSA-383280 1.429764e-07 6.845 0 0
Signaling by Hippo R-HSA-2028269 1.429287e-06 5.845 0 0
RAB geranylgeranylation R-HSA-8873719 1.573088e-06 5.803 0 0
Cell Cycle Checkpoints R-HSA-69620 2.199604e-06 5.658 0 0
Rap1 signalling R-HSA-392517 3.062454e-06 5.514 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.442850e-06 5.264 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.114296e-06 5.091 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.114296e-06 5.091 0 0
Apoptotic execution phase R-HSA-75153 8.574252e-06 5.067 0 0
Cell Cycle R-HSA-1640170 5.065565e-05 4.295 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.867527e-05 4.163 0 0
Oncogene Induced Senescence R-HSA-2559585 7.042148e-05 4.152 0 0
Apoptosis R-HSA-109581 6.531608e-05 4.185 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.401017e-05 4.131 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.731288e-05 4.112 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.558088e-05 4.068 0 0
MAPK family signaling cascades R-HSA-5683057 1.003611e-04 3.998 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.099931e-04 3.959 0 0
Axon guidance R-HSA-422475 1.064909e-04 3.973 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.188692e-04 3.925 0 0
Regulation of TP53 Activity R-HSA-5633007 1.367826e-04 3.864 0 0
Mitotic Prometaphase R-HSA-68877 1.536582e-04 3.813 0 0
NRAGE signals death through JNK R-HSA-193648 1.988647e-04 3.701 0 0
RAF activation R-HSA-5673000 2.599114e-04 3.585 0 0
Cell Cycle, Mitotic R-HSA-69278 2.664539e-04 3.574 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.818245e-04 3.550 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.533418e-04 3.452 0 0
M Phase R-HSA-68886 3.604984e-04 3.443 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.791786e-04 3.421 0 0
RET signaling R-HSA-8853659 3.760255e-04 3.425 0 0
Programmed Cell Death R-HSA-5357801 3.914241e-04 3.407 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.115449e-04 3.386 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.302625e-04 3.366 0 0
Interleukin-37 signaling R-HSA-9008059 4.368261e-04 3.360 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.412336e-04 3.355 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.052858e-04 3.296 0 0
Nervous system development R-HSA-9675108 5.098522e-04 3.293 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.450956e-04 3.264 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.693217e-04 3.245 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.401191e-04 3.194 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.507879e-04 3.187 0 0
Generic Transcription Pathway R-HSA-212436 6.444674e-04 3.191 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.895013e-04 3.161 0 0
Cellular Senescence R-HSA-2559583 6.850253e-04 3.164 0 0
Mitotic Anaphase R-HSA-68882 8.030270e-04 3.095 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.546194e-04 3.068 0 0
Separation of Sister Chromatids R-HSA-2467813 1.018108e-03 2.992 0 0
Death Receptor Signaling R-HSA-73887 1.114731e-03 2.953 1 0
Signaling by ERBB2 R-HSA-1227986 1.150942e-03 2.939 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.317369e-03 2.880 0 0
Rab regulation of trafficking R-HSA-9007101 1.414339e-03 2.849 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.567408e-03 2.805 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.570672e-03 2.804 0 0
DARPP-32 events R-HSA-180024 1.567408e-03 2.805 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.688300e-03 2.773 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.863931e-03 2.730 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.888136e-03 2.724 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.240722e-03 2.650 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.392345e-03 2.621 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.441567e-03 2.612 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.475997e-03 2.606 0 0
Immune System R-HSA-168256 2.434782e-03 2.614 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.513002e-03 2.600 0 0
Specification of primordial germ cells R-HSA-9827857 2.515502e-03 2.599 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.531734e-03 2.597 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.089685e-03 2.510 0 0
FLT3 Signaling R-HSA-9607240 3.089685e-03 2.510 0 0
L1CAM interactions R-HSA-373760 3.106933e-03 2.508 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.477544e-03 2.459 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.529533e-03 2.452 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.627392e-03 2.440 1 0
FOXO-mediated transcription R-HSA-9614085 3.627392e-03 2.440 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.850979e-03 2.414 0 0
MTOR signalling R-HSA-165159 4.017077e-03 2.396 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.510613e-03 2.346 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.856327e-03 2.314 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.856327e-03 2.314 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.856327e-03 2.314 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.323262e-03 2.274 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.385003e-03 2.269 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.120679e-03 2.213 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.513570e-03 2.186 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.513570e-03 2.186 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.513570e-03 2.186 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.432345e-03 2.192 0 0
Signaling by RAS mutants R-HSA-6802949 6.513570e-03 2.186 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.544130e-03 2.184 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.560451e-03 2.183 0 0
RNA Polymerase II Transcription R-HSA-73857 6.775306e-03 2.169 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 6.786976e-03 2.168 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.116919e-03 2.148 0 0
G2/M Checkpoints R-HSA-69481 7.231282e-03 2.141 0 0
Post NMDA receptor activation events R-HSA-438064 6.845074e-03 2.165 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.966064e-03 2.157 0 0
G alpha (12/13) signalling events R-HSA-416482 7.334110e-03 2.135 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.775046e-03 2.109 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.140074e-03 2.089 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.621429e-03 2.064 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 9.296779e-03 2.032 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 9.296779e-03 2.032 0 0
Reproduction R-HSA-1474165 9.323891e-03 2.030 0 0
Muscle contraction R-HSA-397014 9.407748e-03 2.027 0 0
Cardiac conduction R-HSA-5576891 9.916020e-03 2.004 0 0
Integrin signaling R-HSA-354192 1.070023e-02 1.971 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.083234e-02 1.965 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.062152e-02 1.974 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.083234e-02 1.965 0 0
Neurodegenerative Diseases R-HSA-8863678 1.083234e-02 1.965 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.168446e-02 1.932 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.208782e-02 1.918 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.327590e-02 1.877 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.327590e-02 1.877 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.327590e-02 1.877 0 0
Semaphorin interactions R-HSA-373755 1.285548e-02 1.891 0 0
Signaling by VEGF R-HSA-194138 1.337164e-02 1.874 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.285548e-02 1.891 0 0
Signaling by PTK6 R-HSA-8848021 1.285548e-02 1.891 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.372154e-02 1.863 0 0
Ephrin signaling R-HSA-3928664 1.400184e-02 1.854 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.400184e-02 1.854 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 1.467405e-02 1.833 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.467405e-02 1.833 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.467405e-02 1.833 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.467405e-02 1.833 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.467405e-02 1.833 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.528371e-02 1.816 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.544147e-02 1.811 0 0
Netrin-1 signaling R-HSA-373752 1.544755e-02 1.811 0 0
Gene expression (Transcription) R-HSA-74160 1.502868e-02 1.823 0 0
Specification of the neural plate border R-HSA-9834899 1.650299e-02 1.782 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.650299e-02 1.782 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.653098e-02 1.782 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.709153e-02 1.767 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.718875e-02 1.765 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.718875e-02 1.765 0 0
Neutrophil degranulation R-HSA-6798695 1.896194e-02 1.722 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.808591e-02 1.743 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.727712e-02 1.763 0 0
Nef and signal transduction R-HSA-164944 1.808591e-02 1.743 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.730922e-02 1.762 0 0
Interleukin-1 family signaling R-HSA-446652 1.819546e-02 1.740 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.928438e-02 1.715 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.933076e-02 1.714 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.064053e-02 1.685 0 0
Formation of axial mesoderm R-HSA-9796292 2.090787e-02 1.680 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.507311e-02 1.601 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.507311e-02 1.601 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.507311e-02 1.601 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.507311e-02 1.601 0 0
Diseases of cellular response to stress R-HSA-9675132 2.507311e-02 1.601 0 0
C6 deamination of adenosine R-HSA-75102 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.507311e-02 1.601 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.507311e-02 1.601 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.507311e-02 1.601 0 0
PTK6 Expression R-HSA-8849473 2.374084e-02 1.625 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.401812e-02 1.619 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.462566e-02 1.609 0 0
Co-stimulation by CD28 R-HSA-389356 2.277425e-02 1.643 0 0
Membrane Trafficking R-HSA-199991 2.273795e-02 1.643 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.385789e-02 1.622 0 0
Signaling by ALK R-HSA-201556 2.385789e-02 1.622 0 0
HDL assembly R-HSA-8963896 2.508436e-02 1.601 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.573009e-02 1.590 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.972870e-02 1.527 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.941242e-02 1.531 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.010205e-02 1.521 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.972870e-02 1.527 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.972870e-02 1.527 0 0
Cellular responses to stimuli R-HSA-8953897 2.864613e-02 1.543 0 0
Adrenoceptors R-HSA-390696 3.024280e-02 1.519 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.024280e-02 1.519 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.024280e-02 1.519 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.069287e-02 1.513 1 0
Adaptive Immune System R-HSA-1280218 3.176626e-02 1.498 1 0
MAP2K and MAPK activation R-HSA-5674135 3.193606e-02 1.496 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.193606e-02 1.496 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.193606e-02 1.496 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.272142e-02 1.485 0 0
Signaling by ALK in cancer R-HSA-9700206 3.272142e-02 1.485 0 0
ARMS-mediated activation R-HSA-170984 3.758383e-02 1.425 0 0
Meiotic synapsis R-HSA-1221632 3.499529e-02 1.456 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.758383e-02 1.425 0 0
mRNA Editing R-HSA-75072 3.758383e-02 1.425 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.758383e-02 1.425 0 0
Prolonged ERK activation events R-HSA-169893 3.484820e-02 1.458 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.341097e-02 1.476 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.499050e-02 1.456 0 0
Potassium Channels R-HSA-1296071 3.312204e-02 1.480 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.758383e-02 1.425 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.711587e-02 1.430 0 0
Signaling by Interleukins R-HSA-449147 3.663489e-02 1.436 1 0
Lipophagy R-HSA-9613354 3.758383e-02 1.425 0 0
Diseases of programmed cell death R-HSA-9645723 3.758437e-02 1.425 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 3.766166e-02 1.424 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.766166e-02 1.424 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 3.766166e-02 1.424 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.773154e-02 1.423 0 0
Signaling by SCF-KIT R-HSA-1433557 3.823242e-02 1.418 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.044706e-02 1.393 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.237865e-02 1.373 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.237865e-02 1.373 0 0
Ion homeostasis R-HSA-5578775 4.413389e-02 1.355 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.413389e-02 1.355 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.214640e-02 1.283 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.214640e-02 1.283 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.214640e-02 1.283 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.214640e-02 1.283 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.748730e-02 1.323 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.826112e-02 1.316 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.522382e-02 1.345 0 0
Cellular response to chemical stress R-HSA-9711123 5.085265e-02 1.294 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.943051e-02 1.306 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.943051e-02 1.306 0 0
Opioid Signalling R-HSA-111885 5.168787e-02 1.287 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.955980e-02 1.305 0 0
Calmodulin induced events R-HSA-111933 4.945684e-02 1.306 0 0
CaM pathway R-HSA-111997 4.945684e-02 1.306 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.574742e-02 1.340 0 0
EPH-Ephrin signaling R-HSA-2682334 5.034111e-02 1.298 0 0
PI Metabolism R-HSA-1483255 4.650271e-02 1.333 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.749833e-02 1.323 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.063980e-02 1.296 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.266405e-02 1.278 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.266405e-02 1.278 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.308526e-02 1.275 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.308526e-02 1.275 0 0
Voltage gated Potassium channels R-HSA-1296072 5.406802e-02 1.267 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.470998e-02 1.262 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.470998e-02 1.262 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.471762e-02 1.262 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 5.886982e-02 1.230 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 5.886982e-02 1.230 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.886982e-02 1.230 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.893102e-02 1.230 0 0
Meiosis R-HSA-1500620 6.095519e-02 1.215 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.130936e-02 1.212 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.198314e-02 1.208 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.826093e-02 1.166 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.826093e-02 1.166 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.444204e-02 1.191 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.444204e-02 1.191 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.490940e-02 1.125 1 1
RUNX3 regulates p14-ARF R-HSA-8951936 7.490940e-02 1.125 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.490940e-02 1.125 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.490940e-02 1.125 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.490940e-02 1.125 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.490940e-02 1.125 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.490940e-02 1.125 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.490940e-02 1.125 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.058046e-02 1.151 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.260169e-02 1.203 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.638270e-02 1.178 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.826093e-02 1.166 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.762139e-02 1.170 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.257081e-02 1.139 0 0
Mitotic Prophase R-HSA-68875 6.943161e-02 1.158 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.490940e-02 1.125 0 0
Interleukin-2 family signaling R-HSA-451927 6.941497e-02 1.159 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.679605e-02 1.175 0 0
Signaling by LTK R-HSA-9842663 7.490940e-02 1.125 0 0
Activation of BH3-only proteins R-HSA-114452 7.058046e-02 1.151 0 0
NrCAM interactions R-HSA-447038 6.826093e-02 1.166 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.492686e-02 1.125 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.503549e-02 1.125 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.558361e-02 1.122 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.569296e-02 1.121 1 0
Neurexins and neuroligins R-HSA-6794361 7.627488e-02 1.118 0 0
Glycolysis R-HSA-70171 8.004483e-02 1.097 0 0
Co-inhibition by PD-1 R-HSA-389948 8.044639e-02 1.094 0 0
Deubiquitination R-HSA-5688426 8.046949e-02 1.094 1 0
Ub-specific processing proteases R-HSA-5689880 8.209698e-02 1.086 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.399494e-02 1.076 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.526886e-02 1.069 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.576357e-02 1.067 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.576357e-02 1.067 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.576357e-02 1.067 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.576357e-02 1.067 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.576357e-02 1.067 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 8.576357e-02 1.067 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.576357e-02 1.067 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.607409e-02 1.065 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.607409e-02 1.065 0 0
Frs2-mediated activation R-HSA-170968 8.607409e-02 1.065 0 0
Interleukin-6 signaling R-HSA-1059683 8.607409e-02 1.065 0 0
Ca-dependent events R-HSA-111996 8.702766e-02 1.060 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.103297e-01 0.957 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.103297e-01 0.957 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.103297e-01 0.957 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.021129e-01 0.991 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.963667e-02 1.048 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.963667e-02 1.048 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.963667e-02 1.048 0 0
p75NTR signals via NF-kB R-HSA-193639 1.103297e-01 0.957 1 0
DNA Double Strand Break Response R-HSA-5693606 9.031087e-02 1.044 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.143546e-02 1.039 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.021129e-01 0.991 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.339500e-02 1.030 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.069545e-01 0.971 0 0
TNF signaling R-HSA-75893 9.842987e-02 1.007 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.103297e-01 0.957 0 0
Macroautophagy R-HSA-1632852 1.061933e-01 0.974 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.143546e-02 1.039 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.901944e-02 1.004 0 0
Regulation of CDH1 Function R-HSA-9764561 1.044669e-01 0.981 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.069089e-01 0.971 1 1
Cell junction organization R-HSA-446728 1.026069e-01 0.989 0 0
Regulation of KIT signaling R-HSA-1433559 9.789521e-02 1.009 0 0
DAG and IP3 signaling R-HSA-1489509 1.068569e-01 0.971 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.143546e-02 1.039 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.284279e-02 1.032 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.143546e-02 1.039 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.064438e-01 0.973 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.789521e-02 1.009 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.103297e-01 0.957 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.021129e-01 0.991 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.105141e-01 0.957 0 0
Cellular responses to stress R-HSA-2262752 1.105609e-01 0.956 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.116605e-01 0.952 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.117896e-01 0.952 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.121058e-01 0.950 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.142773e-01 0.942 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.142773e-01 0.942 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 1.142773e-01 0.942 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.142773e-01 0.942 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.142773e-01 0.942 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.142773e-01 0.942 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.142773e-01 0.942 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.664259e-01 0.779 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.664259e-01 0.779 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.664259e-01 0.779 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.664259e-01 0.779 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.664259e-01 0.779 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.664259e-01 0.779 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.664259e-01 0.779 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.664259e-01 0.779 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.664259e-01 0.779 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.664259e-01 0.779 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.664259e-01 0.779 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.664259e-01 0.779 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.664259e-01 0.779 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.664259e-01 0.779 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.155072e-01 0.667 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.155072e-01 0.667 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 2.155072e-01 0.667 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.155072e-01 0.667 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 2.155072e-01 0.667 0 0
Potassium transport channels R-HSA-1296067 2.155072e-01 0.667 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.155072e-01 0.667 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.155072e-01 0.667 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 2.155072e-01 0.667 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.240784e-01 0.906 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.240784e-01 0.906 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.240784e-01 0.906 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.240784e-01 0.906 0 0
Axonal growth stimulation R-HSA-209563 2.617013e-01 0.582 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.617013e-01 0.582 0 0
Defective ABCA1 causes TGD R-HSA-5682113 2.617013e-01 0.582 0 0
RSK activation R-HSA-444257 1.445139e-01 0.840 0 0
Activation of RAS in B cells R-HSA-1169092 1.445139e-01 0.840 0 0
NADE modulates death signalling R-HSA-205025 3.051779e-01 0.515 0 0
ATP sensitive Potassium channels R-HSA-1296025 3.051779e-01 0.515 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.051779e-01 0.515 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.051779e-01 0.515 0 0
Defective MAT1A causes MATD R-HSA-5579024 3.051779e-01 0.515 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.051779e-01 0.515 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 3.051779e-01 0.515 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.871337e-01 0.728 0 0
2-LTR circle formation R-HSA-164843 1.871337e-01 0.728 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.871337e-01 0.728 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.871337e-01 0.728 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.090431e-01 0.680 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.090431e-01 0.680 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.090431e-01 0.680 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.090431e-01 0.680 0 0
IRS activation R-HSA-74713 3.460967e-01 0.461 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.460967e-01 0.461 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.460967e-01 0.461 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.460967e-01 0.461 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.460967e-01 0.461 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.460967e-01 0.461 0 0
Defective F9 activation R-HSA-9673221 3.460967e-01 0.461 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.460967e-01 0.461 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.460967e-01 0.461 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 3.460967e-01 0.461 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.311922e-01 0.636 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.311922e-01 0.636 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.653005e-01 0.782 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.534771e-01 0.596 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.534771e-01 0.596 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.846081e-01 0.415 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.846081e-01 0.415 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.846081e-01 0.415 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.846081e-01 0.415 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 3.846081e-01 0.415 0 0
Packaging Of Telomere Ends R-HSA-171306 1.430839e-01 0.844 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 1.952867e-01 0.709 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.758051e-01 0.559 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.758051e-01 0.559 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.758051e-01 0.559 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.107481e-01 0.676 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.107481e-01 0.676 0 0
Signaling by Erythropoietin R-HSA-9006335 1.656422e-01 0.781 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.656422e-01 0.781 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.264645e-01 0.645 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.980939e-01 0.526 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.980939e-01 0.526 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.208536e-01 0.376 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.208536e-01 0.376 0 0
EGFR downregulation R-HSA-182971 1.893658e-01 0.723 0 0
Erythropoietin activates RAS R-HSA-9027284 3.202710e-01 0.494 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.202710e-01 0.494 0 0
Translesion synthesis by REV1 R-HSA-110312 3.202710e-01 0.494 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.202710e-01 0.494 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.202710e-01 0.494 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.140845e-01 0.669 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.140845e-01 0.669 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.901576e-01 0.721 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.267632e-01 0.644 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.422721e-01 0.466 0 0
Translesion synthesis by POLI R-HSA-5656121 3.422721e-01 0.466 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.422721e-01 0.466 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.422721e-01 0.466 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.446822e-01 0.840 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.446822e-01 0.840 0 0
Translation initiation complex formation R-HSA-72649 1.784660e-01 0.748 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.640413e-01 0.439 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.640413e-01 0.439 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.640413e-01 0.439 0 0
Translesion synthesis by POLK R-HSA-5655862 3.640413e-01 0.439 0 0
Phase 2 - plateau phase R-HSA-5576893 3.640413e-01 0.439 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.640413e-01 0.439 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.160835e-01 0.935 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.965242e-01 0.707 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.212058e-01 0.916 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.152289e-01 0.667 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.239124e-01 0.490 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.855296e-01 0.414 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.855296e-01 0.414 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.855296e-01 0.414 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.403464e-01 0.468 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.403464e-01 0.468 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.059738e-01 0.514 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.250199e-01 0.648 0 0
DNA methylation R-HSA-5334118 3.567511e-01 0.448 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.567511e-01 0.448 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.195090e-01 0.496 0 0
Centrosome maturation R-HSA-380287 2.426977e-01 0.615 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.983590e-01 0.703 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.011581e-01 0.521 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.730990e-01 0.428 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.730990e-01 0.428 0 0
Regulation of signaling by CBL R-HSA-912631 4.275000e-01 0.369 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.275000e-01 0.369 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.399134e-01 0.620 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.128614e-01 0.505 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.893645e-01 0.410 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.893645e-01 0.410 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.479146e-01 0.349 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.479146e-01 0.349 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.479146e-01 0.349 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.479146e-01 0.349 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.215540e-01 0.375 0 0
Metabolism of non-coding RNA R-HSA-194441 3.838896e-01 0.416 0 0
snRNP Assembly R-HSA-191859 3.838896e-01 0.416 0 0
Peptide chain elongation R-HSA-156902 3.752045e-01 0.426 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.045217e-01 0.393 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.264507e-01 0.898 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.074785e-01 0.512 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.107481e-01 0.676 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.107481e-01 0.676 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.508644e-01 0.821 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.508644e-01 0.821 0 0
Formation of definitive endoderm R-HSA-9823730 1.952867e-01 0.709 0 0
MHC class II antigen presentation R-HSA-2132295 4.511092e-01 0.346 0 0
Signaling by EGFR R-HSA-177929 1.965242e-01 0.707 0 0
RUNX2 regulates bone development R-HSA-8941326 2.658203e-01 0.575 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.090431e-01 0.680 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.322936e-01 0.878 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.330880e-01 0.477 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.466928e-01 0.460 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.564952e-01 0.591 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.542069e-01 0.812 0 0
Signal attenuation R-HSA-74749 1.871337e-01 0.728 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.980939e-01 0.526 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.640413e-01 0.439 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.871337e-01 0.728 0 0
DCC mediated attractive signaling R-HSA-418885 3.202710e-01 0.494 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.910759e-01 0.536 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.965242e-01 0.707 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.068675e-01 0.684 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.567511e-01 0.448 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.445139e-01 0.840 0 0
Regulation of CDH11 function R-HSA-9762292 1.871337e-01 0.728 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 1.233331e-01 0.909 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.508644e-01 0.821 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.846081e-01 0.415 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.640413e-01 0.439 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.791100e-01 0.554 0 0
Homology Directed Repair R-HSA-5693538 1.841612e-01 0.735 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.264507e-01 0.898 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.801228e-01 0.744 0 0
Interleukin-9 signaling R-HSA-8985947 1.445139e-01 0.840 0 0
Cyclin D associated events in G1 R-HSA-69231 3.874919e-01 0.412 0 0
G1 Phase R-HSA-69236 3.874919e-01 0.412 0 0
IGF1R signaling cascade R-HSA-2428924 4.429033e-01 0.354 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.655806e-01 0.781 0 0
Regulation of gap junction activity R-HSA-191650 3.051779e-01 0.515 0 0
Signaling by MST1 R-HSA-8852405 3.846081e-01 0.415 0 0
cGMP effects R-HSA-418457 2.980939e-01 0.526 0 0
Telomere C-strand synthesis initiation R-HSA-174430 3.202710e-01 0.494 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.403464e-01 0.468 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.195090e-01 0.496 0 0
Translesion Synthesis by POLH R-HSA-110320 4.275000e-01 0.369 0 0
Downstream TCR signaling R-HSA-202424 3.947473e-01 0.404 1 1
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.397523e-01 0.620 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.180247e-01 0.928 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.893645e-01 0.410 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.910175e-01 0.536 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.183258e-01 0.378 0 0
Nuclear import of Rev protein R-HSA-180746 2.396261e-01 0.620 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.055235e-01 0.392 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.511092e-01 0.346 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.925011e-01 0.534 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.858008e-01 0.414 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.195090e-01 0.496 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.051779e-01 0.515 0 0
Activation of AKT2 R-HSA-165158 3.460967e-01 0.461 0 0
Metalloprotease DUBs R-HSA-5689901 1.322936e-01 0.878 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.208536e-01 0.376 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.202710e-01 0.494 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.375212e-01 0.862 0 0
Tight junction interactions R-HSA-420029 2.910759e-01 0.536 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.983590e-01 0.703 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.215540e-01 0.375 0 0
PTEN Regulation R-HSA-6807070 2.434735e-01 0.614 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.994042e-01 0.700 0 0
Triglyceride catabolism R-HSA-163560 1.235727e-01 0.908 0 0
Recycling pathway of L1 R-HSA-437239 1.212616e-01 0.916 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.267632e-01 0.644 0 0
TCR signaling R-HSA-202403 2.118035e-01 0.674 1 0
Interleukin-2 signaling R-HSA-9020558 2.090431e-01 0.680 0 0
The NLRP3 inflammasome R-HSA-844456 1.801228e-01 0.744 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.139437e-01 0.943 0 0
Signaling by TGFB family members R-HSA-9006936 3.966905e-01 0.402 0 0
G alpha (s) signalling events R-HSA-418555 2.688525e-01 0.570 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.460967e-01 0.461 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.202710e-01 0.494 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.422721e-01 0.466 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.925011e-01 0.534 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.059738e-01 0.514 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.055235e-01 0.392 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.330880e-01 0.477 0 0
Autophagy R-HSA-9612973 1.783047e-01 0.749 0 0
Apoptotic factor-mediated response R-HSA-111471 1.653005e-01 0.782 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.107481e-01 0.676 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 1.656422e-01 0.781 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.526522e-01 0.597 0 0
Selective autophagy R-HSA-9663891 1.405011e-01 0.852 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.855296e-01 0.414 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.689476e-01 0.570 0 0
Interferon gamma signaling R-HSA-877300 2.823577e-01 0.549 0 0
Signalling to ERKs R-HSA-187687 1.150962e-01 0.939 0 0
Signaling by WNT in cancer R-HSA-4791275 2.016115e-01 0.695 0 0
Hedgehog 'off' state R-HSA-5610787 2.364704e-01 0.626 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.215540e-01 0.375 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.534771e-01 0.596 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.689476e-01 0.570 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.240467e-01 0.373 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.097845e-01 0.387 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 1.508644e-01 0.821 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.180247e-01 0.928 0 0
Gastrulation R-HSA-9758941 1.442305e-01 0.841 0 0
G alpha (z) signalling events R-HSA-418597 3.364310e-01 0.473 0 0
Stabilization of p53 R-HSA-69541 3.059738e-01 0.514 0 0
DNA Repair R-HSA-73894 4.494872e-01 0.347 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.079328e-01 0.682 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.664259e-01 0.779 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.664259e-01 0.779 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.155072e-01 0.667 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 2.155072e-01 0.667 0 0
Regulation of PTEN localization R-HSA-8948747 1.240784e-01 0.906 0 0
MET interacts with TNS proteins R-HSA-8875513 2.617013e-01 0.582 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.445139e-01 0.840 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.051779e-01 0.515 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.051779e-01 0.515 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.233331e-01 0.909 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.090431e-01 0.680 0 0
Signaling by APC mutants R-HSA-4839744 2.090431e-01 0.680 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.311922e-01 0.636 0 0
NF-kB is activated and signals survival R-HSA-209560 2.311922e-01 0.636 0 0
Signaling by AXIN mutants R-HSA-4839735 2.311922e-01 0.636 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.311922e-01 0.636 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.653005e-01 0.782 0 0
PKA activation R-HSA-163615 1.653005e-01 0.782 0 0
PKA activation in glucagon signalling R-HSA-164378 1.653005e-01 0.782 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.846081e-01 0.415 0 0
Ceramide signalling R-HSA-193681 3.846081e-01 0.415 0 0
Formation of the Editosome R-HSA-75094 3.846081e-01 0.415 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.758051e-01 0.559 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.208536e-01 0.376 0 0
GPER1 signaling R-HSA-9634597 1.288054e-01 0.890 0 0
Intra-Golgi traffic R-HSA-6811438 1.799470e-01 0.745 0 0
Triglyceride metabolism R-HSA-8979227 2.248025e-01 0.648 0 0
Platelet calcium homeostasis R-HSA-418360 3.567511e-01 0.448 0 0
Mitochondrial biogenesis R-HSA-1592230 1.781660e-01 0.749 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.244938e-01 0.905 0 0
Negative regulation of MET activity R-HSA-6807004 4.479146e-01 0.349 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.010329e-01 0.397 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.179009e-01 0.379 0 0
GPCR downstream signalling R-HSA-388396 3.615857e-01 0.442 0 0
Hedgehog 'on' state R-HSA-5632684 2.078142e-01 0.682 0 0
Vesicle-mediated transport R-HSA-5653656 2.669293e-01 0.574 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.078142e-01 0.682 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.078142e-01 0.682 0 0
S Phase R-HSA-69242 3.108355e-01 0.507 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.980383e-01 0.526 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.345117e-01 0.630 0 0
HATs acetylate histones R-HSA-3214847 3.526577e-01 0.453 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.656422e-01 0.781 0 0
Signaling by Hedgehog R-HSA-5358351 2.370528e-01 0.625 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.058000e-01 0.687 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.486295e-01 0.828 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.322936e-01 0.878 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.202710e-01 0.494 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.665251e-01 0.574 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.665251e-01 0.574 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.643642e-01 0.578 0 0
ESR-mediated signaling R-HSA-8939211 3.021394e-01 0.520 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 1.655806e-01 0.781 0 0
Host Interactions of HIV factors R-HSA-162909 2.219932e-01 0.654 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.698653e-01 0.432 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.396758e-01 0.855 1 0
Integration of energy metabolism R-HSA-163685 1.447305e-01 0.839 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.195090e-01 0.496 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.195090e-01 0.496 0 0
Toll-like Receptor Cascades R-HSA-168898 2.978957e-01 0.526 1 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.140845e-01 0.669 0 0
Negative regulation of FLT3 R-HSA-9706369 1.233331e-01 0.909 0 0
Signaling by NODAL R-HSA-1181150 4.479146e-01 0.349 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.434866e-01 0.353 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.322936e-01 0.878 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.773689e-01 0.751 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.374959e-01 0.472 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.460967e-01 0.461 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.846081e-01 0.415 0 0
Signaling by Activin R-HSA-1502540 3.202710e-01 0.494 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.466928e-01 0.460 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.466928e-01 0.460 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.583323e-01 0.446 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.374354e-01 0.359 0 0
Neuronal System R-HSA-112316 1.392613e-01 0.856 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.902487e-01 0.721 1 0
Inflammasomes R-HSA-622312 3.403464e-01 0.468 0 0
Signaling by TGFBR3 R-HSA-9839373 4.145197e-01 0.382 0 0
Pexophagy R-HSA-9664873 1.871337e-01 0.728 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.902487e-01 0.721 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.090432e-01 0.680 1 0
Cell-cell junction organization R-HSA-421270 1.560283e-01 0.807 0 0
Adherens junctions interactions R-HSA-418990 2.041054e-01 0.690 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.240784e-01 0.906 0 0
PLC beta mediated events R-HSA-112043 1.305386e-01 0.884 0 0
Differentiation of T cells R-HSA-9945266 3.422721e-01 0.466 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.422721e-01 0.466 0 0
Regulation of BACH1 activity R-HSA-9708530 3.422721e-01 0.466 0 0
Smooth Muscle Contraction R-HSA-445355 1.697000e-01 0.770 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.090432e-01 0.680 1 0
G2/M Transition R-HSA-69275 2.679706e-01 0.572 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.243069e-01 0.489 1 0
Ca2+ pathway R-HSA-4086398 3.689893e-01 0.433 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.243069e-01 0.489 1 0
Mitotic G2-G2/M phases R-HSA-453274 2.798150e-01 0.553 0 0
Developmental Biology R-HSA-1266738 1.863700e-01 0.730 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.556938e-01 0.592 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.521938e-01 0.345 1 0
SLC-mediated transport of neurotransmitters R-HSA-442660 1.799470e-01 0.745 0 0
Diseases of Immune System R-HSA-5260271 3.195090e-01 0.496 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.195090e-01 0.496 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.836173e-01 0.416 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.607537e-01 0.794 0 0
Signaling by MET R-HSA-6806834 4.434866e-01 0.353 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.214784e-01 0.655 1 0
Cell-Cell communication R-HSA-1500931 1.278335e-01 0.893 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.214784e-01 0.655 1 0
Innate Immune System R-HSA-168249 1.893141e-01 0.723 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.214784e-01 0.655 1 0
Breakdown of the nuclear lamina R-HSA-352238 1.664259e-01 0.779 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.617013e-01 0.582 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.051779e-01 0.515 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.460967e-01 0.461 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.846081e-01 0.415 0 0
rRNA modification in the mitochondrion R-HSA-6793080 2.758051e-01 0.559 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.139437e-01 0.943 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.910759e-01 0.536 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.152289e-01 0.667 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.345117e-01 0.630 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.903313e-01 0.409 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.834179e-01 0.548 1 0
Signaling by NOTCH R-HSA-157118 3.188545e-01 0.496 0 0
Signaling by FGFR2 R-HSA-5654738 4.434866e-01 0.353 0 0
Signaling by NOTCH3 R-HSA-9012852 1.874101e-01 0.727 0 0
Platelet homeostasis R-HSA-418346 2.914869e-01 0.535 0 0
Interleukin-1 signaling R-HSA-9020702 2.440996e-01 0.612 1 1
Glycogen metabolism R-HSA-8982491 1.601773e-01 0.795 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.567511e-01 0.448 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.111678e-01 0.675 0 0
Amine ligand-binding receptors R-HSA-375280 2.111678e-01 0.675 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.010329e-01 0.397 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.497473e-01 0.825 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.279384e-01 0.369 0 0
Ion transport by P-type ATPases R-HSA-936837 2.745265e-01 0.561 0 0
G-protein mediated events R-HSA-112040 1.750183e-01 0.757 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.655806e-01 0.781 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.208536e-01 0.376 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.239124e-01 0.490 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.215540e-01 0.375 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.551824e-01 0.593 0 0
Signaling by NTRKs R-HSA-166520 1.396758e-01 0.855 0 0
Signaling by FGFR1 R-HSA-5654736 3.482732e-01 0.458 0 0
Signaling by FGFR4 R-HSA-5654743 3.739111e-01 0.427 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.264645e-01 0.645 0 0
Hemostasis R-HSA-109582 4.528056e-01 0.344 0 0
Signaling by FGFR3 R-HSA-5654741 4.010329e-01 0.397 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.664259e-01 0.779 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.240784e-01 0.906 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.617013e-01 0.582 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.051779e-01 0.515 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.460967e-01 0.461 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.758051e-01 0.559 0 0
CREB phosphorylation R-HSA-199920 4.208536e-01 0.376 0 0
Signaling by NOTCH4 R-HSA-9013694 2.338030e-01 0.631 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.730990e-01 0.428 0 0
MAP kinase activation R-HSA-450294 4.075984e-01 0.390 1 0
Heme signaling R-HSA-9707616 4.194108e-01 0.377 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.466928e-01 0.460 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.431794e-01 0.353 1 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.893645e-01 0.410 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.079328e-01 0.682 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.396450e-01 0.469 1 0
Cleavage of the damaged purine R-HSA-110331 2.791100e-01 0.554 0 0
Integration of provirus R-HSA-162592 2.311922e-01 0.636 0 0
TBC/RABGAPs R-HSA-8854214 2.005688e-01 0.698 0 0
Inositol phosphate metabolism R-HSA-1483249 3.409830e-01 0.467 0 0
Formation of the nephric duct R-HSA-9830364 2.910759e-01 0.536 0 0
Depurination R-HSA-73927 2.925011e-01 0.534 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.936967e-01 0.532 0 0
Interleukin-6 family signaling R-HSA-6783589 2.747376e-01 0.561 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.482732e-01 0.458 0 0
Diseases of DNA repair R-HSA-9675135 4.145197e-01 0.382 0 0
Interleukin-12 family signaling R-HSA-447115 2.317629e-01 0.635 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.846081e-01 0.415 0 0
VLDL assembly R-HSA-8866423 4.208536e-01 0.376 0 0
HDL clearance R-HSA-8964011 4.208536e-01 0.376 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.016115e-01 0.695 0 0
G-protein beta:gamma signalling R-HSA-397795 2.140845e-01 0.669 0 0
Synthesis of PG R-HSA-1483148 3.640413e-01 0.439 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.370873e-01 0.472 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.145197e-01 0.382 0 0
Ion channel transport R-HSA-983712 2.858017e-01 0.544 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.611200e-01 0.793 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.914869e-01 0.535 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.240467e-01 0.373 0 0
Aspartate and asparagine metabolism R-HSA-8963693 3.893645e-01 0.410 0 0
Signal transduction by L1 R-HSA-445144 4.479146e-01 0.349 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.045217e-01 0.393 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.567511e-01 0.448 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.215540e-01 0.375 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.374354e-01 0.359 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.239124e-01 0.490 0 0
Stimuli-sensing channels R-HSA-2672351 3.077967e-01 0.512 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.090431e-01 0.680 0 0
IRE1alpha activates chaperones R-HSA-381070 4.142901e-01 0.383 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.758051e-01 0.559 0 0
Glucose metabolism R-HSA-70326 1.781660e-01 0.749 0 0
Cardiogenesis R-HSA-9733709 4.215540e-01 0.375 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.871337e-01 0.728 0 0
Neurofascin interactions R-HSA-447043 4.208536e-01 0.376 0 0
Growth hormone receptor signaling R-HSA-982772 2.584982e-01 0.588 0 0
TRP channels R-HSA-3295583 3.074785e-01 0.512 0 0
Tie2 Signaling R-HSA-210993 4.066946e-01 0.391 0 0
OAS antiviral response R-HSA-8983711 2.534771e-01 0.596 0 0
Polo-like kinase mediated events R-HSA-156711 4.066946e-01 0.391 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.066946e-01 0.391 0 0
Platelet sensitization by LDL R-HSA-432142 4.066946e-01 0.391 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.202710e-01 0.494 0 0
Interleukin-12 signaling R-HSA-9020591 2.516975e-01 0.599 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.847794e-01 0.545 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.801228e-01 0.744 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.603061e-01 0.443 0 0
Depyrimidination R-HSA-73928 3.603061e-01 0.443 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.396261e-01 0.620 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.531488e-01 0.344 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.531488e-01 0.344 0 0
Mitophagy R-HSA-5205647 4.531488e-01 0.344 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.531488e-01 0.344 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.531488e-01 0.344 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.531488e-01 0.344 0 0
Amyloid fiber formation R-HSA-977225 4.540249e-01 0.343 0 0
DNA Damage Bypass R-HSA-73893 4.545191e-01 0.342 0 0
Degradation of CDH1 R-HSA-9766229 4.545191e-01 0.342 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.545650e-01 0.342 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.549663e-01 0.342 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.549663e-01 0.342 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.549663e-01 0.342 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.549663e-01 0.342 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.549663e-01 0.342 0 0
SOS-mediated signalling R-HSA-112412 4.549663e-01 0.342 0 0
Disinhibition of SNARE formation R-HSA-114516 4.549663e-01 0.342 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.549663e-01 0.342 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.549663e-01 0.342 0 0
LDL remodeling R-HSA-8964041 4.549663e-01 0.342 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.549663e-01 0.342 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.549663e-01 0.342 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.549663e-01 0.342 0 0
G alpha (q) signalling events R-HSA-416476 4.583864e-01 0.339 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.679125e-01 0.330 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.679125e-01 0.330 0 0
ERK/MAPK targets R-HSA-198753 4.679125e-01 0.330 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.679125e-01 0.330 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.686771e-01 0.329 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.686771e-01 0.329 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.724580e-01 0.326 0 0
G1/S Transition R-HSA-69206 4.763758e-01 0.322 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.768373e-01 0.322 1 0
Meiotic recombination R-HSA-912446 4.806783e-01 0.318 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.840045e-01 0.315 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.840045e-01 0.315 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.840045e-01 0.315 0 0
GPVI-mediated activation cascade R-HSA-114604 4.840045e-01 0.315 0 0
Type I hemidesmosome assembly R-HSA-446107 4.870717e-01 0.312 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.870717e-01 0.312 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.870717e-01 0.312 0 0
Formation of annular gap junctions R-HSA-196025 4.870717e-01 0.312 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.870717e-01 0.312 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.870717e-01 0.312 0 0
Regulation by c-FLIP R-HSA-3371378 4.870717e-01 0.312 0 0
Co-stimulation by ICOS R-HSA-9927354 4.870717e-01 0.312 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.870717e-01 0.312 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.870717e-01 0.312 0 0
Dimerization of procaspase-8 R-HSA-69416 4.870717e-01 0.312 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.870717e-01 0.312 0 0
Interleukin-23 signaling R-HSA-9020933 4.870717e-01 0.312 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.874718e-01 0.312 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.874718e-01 0.312 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.874718e-01 0.312 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.874718e-01 0.312 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.874718e-01 0.312 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.874718e-01 0.312 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.874718e-01 0.312 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.874718e-01 0.312 0 0
Interferon Signaling R-HSA-913531 4.879533e-01 0.312 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.879598e-01 0.312 1 0
Regulation of insulin secretion R-HSA-422356 4.915517e-01 0.308 0 0
Signaling by FGFR R-HSA-190236 4.915517e-01 0.308 0 0
Platelet degranulation R-HSA-114608 4.930795e-01 0.307 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.991169e-01 0.302 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.991169e-01 0.302 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.058905e-01 0.296 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.063304e-01 0.296 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.063304e-01 0.296 0 0
FGFR2 alternative splicing R-HSA-6803529 5.065750e-01 0.295 0 0
Notch-HLH transcription pathway R-HSA-350054 5.065750e-01 0.295 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.065750e-01 0.295 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.065750e-01 0.295 0 0
mTORC1-mediated signalling R-HSA-166208 5.065750e-01 0.295 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.065750e-01 0.295 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.065750e-01 0.295 0 0
Signaling by KIT in disease R-HSA-9669938 5.065750e-01 0.295 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.065750e-01 0.295 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.116973e-01 0.291 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.116973e-01 0.291 0 0
Interleukin-17 signaling R-HSA-448424 5.116973e-01 0.291 1 0
SARS-CoV-1 Infection R-HSA-9678108 5.124469e-01 0.290 0 0
MET promotes cell motility R-HSA-8875878 5.140014e-01 0.289 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.140014e-01 0.289 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.143663e-01 0.289 1 0
XBP1(S) activates chaperone genes R-HSA-381038 5.160575e-01 0.287 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.172877e-01 0.286 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.172877e-01 0.286 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.172877e-01 0.286 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.172877e-01 0.286 0 0
Gap junction degradation R-HSA-190873 5.172877e-01 0.286 0 0
CASP8 activity is inhibited R-HSA-5218900 5.172877e-01 0.286 0 0
ALK mutants bind TKIs R-HSA-9700645 5.172877e-01 0.286 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.172877e-01 0.286 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.172877e-01 0.286 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.172877e-01 0.286 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.172877e-01 0.286 0 0
Interleukin-21 signaling R-HSA-9020958 5.172877e-01 0.286 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.172877e-01 0.286 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.172877e-01 0.286 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.172877e-01 0.286 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.189427e-01 0.285 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.228367e-01 0.282 0 0
Interleukin-20 family signaling R-HSA-8854691 5.252078e-01 0.280 0 0
Syndecan interactions R-HSA-3000170 5.252078e-01 0.280 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.252078e-01 0.280 0 0
Pentose phosphate pathway R-HSA-71336 5.286467e-01 0.277 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.286467e-01 0.277 0 0
HIV Infection R-HSA-162906 5.336901e-01 0.273 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.364358e-01 0.270 0 0
Influenza Infection R-HSA-168255 5.406099e-01 0.267 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.430426e-01 0.265 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.430426e-01 0.265 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.430426e-01 0.265 0 0
Generation of second messenger molecules R-HSA-202433 5.430426e-01 0.265 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.430426e-01 0.265 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.433594e-01 0.265 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 5.433594e-01 0.265 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.433594e-01 0.265 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.436984e-01 0.265 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.447764e-01 0.264 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.457255e-01 0.263 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.457255e-01 0.263 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.457255e-01 0.263 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.457255e-01 0.263 0 0
Formation of apoptosome R-HSA-111458 5.457255e-01 0.263 0 0
PI3K/AKT activation R-HSA-198203 5.457255e-01 0.263 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.457255e-01 0.263 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.457255e-01 0.263 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.457255e-01 0.263 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.457255e-01 0.263 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.457255e-01 0.263 0 0
Interleukin-27 signaling R-HSA-9020956 5.457255e-01 0.263 0 0
Maturation of spike protein R-HSA-9683686 5.457255e-01 0.263 0 0
Sperm Motility And Taxes R-HSA-1300642 5.457255e-01 0.263 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 5.457255e-01 0.263 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.457255e-01 0.263 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.457255e-01 0.263 0 0
Serotonin receptors R-HSA-390666 5.457255e-01 0.263 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.457255e-01 0.263 0 0
Signaling by Leptin R-HSA-2586552 5.457255e-01 0.263 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.457255e-01 0.263 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.474206e-01 0.262 0 0
Base Excision Repair R-HSA-73884 5.558653e-01 0.255 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.571801e-01 0.254 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.571801e-01 0.254 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.571801e-01 0.254 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.571801e-01 0.254 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.571801e-01 0.254 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.610218e-01 0.251 0 0
TGFBR3 expression R-HSA-9839394 5.610218e-01 0.251 0 0
Long-term potentiation R-HSA-9620244 5.610218e-01 0.251 0 0
HDMs demethylate histones R-HSA-3214842 5.610218e-01 0.251 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.610218e-01 0.251 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.624309e-01 0.250 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.662269e-01 0.247 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.662269e-01 0.247 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.667246e-01 0.247 0 0
SLC transporter disorders R-HSA-5619102 5.674258e-01 0.246 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.677812e-01 0.246 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.682029e-01 0.245 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.710517e-01 0.243 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.710517e-01 0.243 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.724895e-01 0.242 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.724895e-01 0.242 0 0
vRNA Synthesis R-HSA-192814 5.724895e-01 0.242 0 0
Chylomicron assembly R-HSA-8963888 5.724895e-01 0.242 0 0
Synthesis of PI R-HSA-1483226 5.724895e-01 0.242 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 5.724895e-01 0.242 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.724895e-01 0.242 0 0
PECAM1 interactions R-HSA-210990 5.724895e-01 0.242 0 0
Metabolism of RNA R-HSA-8953854 5.730546e-01 0.242 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.751910e-01 0.240 0 0
Signaling by NOTCH1 R-HSA-1980143 5.767561e-01 0.239 0 0
Chromatin modifying enzymes R-HSA-3247509 5.768857e-01 0.239 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.781897e-01 0.238 0 0
Myogenesis R-HSA-525793 5.781897e-01 0.238 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.781897e-01 0.238 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.781897e-01 0.238 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.781897e-01 0.238 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.781897e-01 0.238 0 0
Extension of Telomeres R-HSA-180786 5.795548e-01 0.237 0 0
Regulation of beta-cell development R-HSA-186712 5.795548e-01 0.237 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.831745e-01 0.234 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.846506e-01 0.233 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.846506e-01 0.233 0 0
Signaling by ROBO receptors R-HSA-376176 5.885022e-01 0.230 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.904346e-01 0.229 0 0
Signaling by GPCR R-HSA-372790 5.908035e-01 0.229 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.948601e-01 0.226 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.948601e-01 0.226 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.948601e-01 0.226 0 0
Insulin processing R-HSA-264876 5.948601e-01 0.226 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.948601e-01 0.226 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.961648e-01 0.225 0 0
Ribosome-associated quality control R-HSA-9948299 5.971327e-01 0.224 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.974008e-01 0.224 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.976782e-01 0.224 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.976782e-01 0.224 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.976782e-01 0.224 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.976782e-01 0.224 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.976782e-01 0.224 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.976782e-01 0.224 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.976782e-01 0.224 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.976782e-01 0.224 0 0
ERKs are inactivated R-HSA-202670 5.976782e-01 0.224 0 0
Activation of RAC1 R-HSA-428540 5.976782e-01 0.224 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 5.976782e-01 0.224 0 0
Sodium/Calcium exchangers R-HSA-425561 5.976782e-01 0.224 0 0
Defective pyroptosis R-HSA-9710421 5.979713e-01 0.223 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.015892e-01 0.221 0 0
Transmission across Chemical Synapses R-HSA-112315 6.015892e-01 0.221 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.033777e-01 0.219 0 0
Sensory processing of sound R-HSA-9659379 6.075086e-01 0.216 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.075086e-01 0.216 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.110093e-01 0.214 0 0
DAP12 interactions R-HSA-2172127 6.110093e-01 0.214 0 0
Telomere Extension By Telomerase R-HSA-171319 6.110319e-01 0.214 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.110319e-01 0.214 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.110319e-01 0.214 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.125352e-01 0.213 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.125352e-01 0.213 0 0
tRNA processing in the nucleus R-HSA-6784531 6.137433e-01 0.212 0 0
Leading Strand Synthesis R-HSA-69109 6.213842e-01 0.207 0 0
Polymerase switching R-HSA-69091 6.213842e-01 0.207 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.213842e-01 0.207 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.213842e-01 0.207 0 0
Regulation of IFNG signaling R-HSA-877312 6.213842e-01 0.207 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.213842e-01 0.207 0 0
Interleukin-35 Signalling R-HSA-8984722 6.213842e-01 0.207 0 0
MET activates RAS signaling R-HSA-8851805 6.213842e-01 0.207 0 0
Interleukin-15 signaling R-HSA-8983432 6.213842e-01 0.207 0 0
Repression of WNT target genes R-HSA-4641265 6.213842e-01 0.207 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.213842e-01 0.207 0 0
Pervasive developmental disorders R-HSA-9005895 6.213842e-01 0.207 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.213842e-01 0.207 0 0
Disorders of Nervous System Development R-HSA-9697154 6.213842e-01 0.207 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.213842e-01 0.207 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.215807e-01 0.207 0 0
Eukaryotic Translation Termination R-HSA-72764 6.215807e-01 0.207 0 0
Nucleosome assembly R-HSA-774815 6.237607e-01 0.205 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.237607e-01 0.205 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.237607e-01 0.205 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.237607e-01 0.205 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.237607e-01 0.205 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.237607e-01 0.205 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.267060e-01 0.203 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.267060e-01 0.203 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.267060e-01 0.203 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.276609e-01 0.202 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.305047e-01 0.200 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.343185e-01 0.198 1 1
Condensation of Prophase Chromosomes R-HSA-2299718 6.362229e-01 0.196 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.362229e-01 0.196 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.362229e-01 0.196 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.369346e-01 0.196 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.369346e-01 0.196 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.390550e-01 0.194 0 0
Telomere Maintenance R-HSA-157579 6.393049e-01 0.194 0 0
Activation of the pre-replicative complex R-HSA-68962 6.418849e-01 0.193 0 0
DAP12 signaling R-HSA-2424491 6.418849e-01 0.193 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.418849e-01 0.193 0 0
Neurotransmitter clearance R-HSA-112311 6.418849e-01 0.193 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.418849e-01 0.193 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.436948e-01 0.191 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.436948e-01 0.191 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.436948e-01 0.191 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.436948e-01 0.191 0 0
Mtb iron assimilation by chelation R-HSA-1222449 6.436948e-01 0.191 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.436948e-01 0.191 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.436948e-01 0.191 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.436948e-01 0.191 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.436948e-01 0.191 0 0
Developmental Cell Lineages R-HSA-9734767 6.455196e-01 0.190 0 0
Cellular response to hypoxia R-HSA-1234174 6.461532e-01 0.190 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.483939e-01 0.188 1 1
Signaling by WNT R-HSA-195721 6.485011e-01 0.188 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.557780e-01 0.183 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.565726e-01 0.183 0 0
Trafficking of AMPA receptors R-HSA-399719 6.565726e-01 0.183 0 0
Cargo concentration in the ER R-HSA-5694530 6.565726e-01 0.183 0 0
Downstream signal transduction R-HSA-186763 6.565726e-01 0.183 0 0
Chromatin organization R-HSA-4839726 6.634351e-01 0.178 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.646919e-01 0.177 0 0
Prolactin receptor signaling R-HSA-1170546 6.646919e-01 0.177 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.646919e-01 0.177 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.646919e-01 0.177 0 0
Physiological factors R-HSA-5578768 6.646919e-01 0.177 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.646919e-01 0.177 0 0
Malate-aspartate shuttle R-HSA-9856872 6.646919e-01 0.177 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.646919e-01 0.177 0 0
Signal regulatory protein family interactions R-HSA-391160 6.646919e-01 0.177 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.646919e-01 0.177 0 0
Selenoamino acid metabolism R-HSA-2408522 6.653122e-01 0.177 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.667353e-01 0.176 0 0
Adipogenesis R-HSA-9843745 6.675540e-01 0.176 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.718578e-01 0.173 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.718578e-01 0.173 0 0
Selenocysteine synthesis R-HSA-2408557 6.732290e-01 0.172 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.767139e-01 0.170 0 0
Regulated Necrosis R-HSA-5218859 6.767139e-01 0.170 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.831502e-01 0.165 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.844529e-01 0.165 0 0
Protein lipoylation R-HSA-9857492 6.844529e-01 0.165 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.844529e-01 0.165 0 0
Protein repair R-HSA-5676934 6.844529e-01 0.165 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.844529e-01 0.165 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 6.844529e-01 0.165 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.844529e-01 0.165 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.844529e-01 0.165 0 0
Protein methylation R-HSA-8876725 6.844529e-01 0.165 0 0
Formation of the anterior neural plate R-HSA-9823739 6.844529e-01 0.165 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.844960e-01 0.165 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.844960e-01 0.165 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.844960e-01 0.165 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.844960e-01 0.165 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.844960e-01 0.165 0 0
Viral mRNA Translation R-HSA-192823 6.894038e-01 0.162 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.941505e-01 0.159 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.941505e-01 0.159 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.941505e-01 0.159 0 0
COPII-mediated vesicle transport R-HSA-204005 6.960415e-01 0.157 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.972905e-01 0.157 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.977452e-01 0.156 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.977452e-01 0.156 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.977452e-01 0.156 0 0
Neddylation R-HSA-8951664 7.016521e-01 0.154 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 7.030503e-01 0.153 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.030503e-01 0.153 0 0
Attachment and Entry R-HSA-9678110 7.030503e-01 0.153 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.030503e-01 0.153 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.030503e-01 0.153 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.030503e-01 0.153 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.030503e-01 0.153 0 0
Activation of SMO R-HSA-5635838 7.030503e-01 0.153 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.030503e-01 0.153 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.048598e-01 0.152 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.048598e-01 0.152 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.093637e-01 0.149 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.093637e-01 0.149 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.093937e-01 0.149 0 0
Chromosome Maintenance R-HSA-73886 7.104318e-01 0.148 0 0
Dual Incision in GG-NER R-HSA-5696400 7.105298e-01 0.148 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.105298e-01 0.148 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.105298e-01 0.148 0 0
eNOS activation R-HSA-203615 7.105298e-01 0.148 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.105298e-01 0.148 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.105298e-01 0.148 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.145280e-01 0.146 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.145280e-01 0.146 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.152799e-01 0.146 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.152799e-01 0.146 0 0
SARS-CoV Infections R-HSA-9679506 7.178167e-01 0.144 1 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.205528e-01 0.142 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.205528e-01 0.142 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.205528e-01 0.142 0 0
Glycine degradation R-HSA-6783984 7.205528e-01 0.142 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.205528e-01 0.142 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.205528e-01 0.142 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.205528e-01 0.142 0 0
Heme assimilation R-HSA-9927020 7.205528e-01 0.142 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.205528e-01 0.142 0 0
Disorders of Developmental Biology R-HSA-9675151 7.205528e-01 0.142 0 0
Galactose catabolism R-HSA-70370 7.205528e-01 0.142 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.205528e-01 0.142 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 7.205528e-01 0.142 0 0
Cilium Assembly R-HSA-5617833 7.214834e-01 0.142 0 0
Regulation of Apoptosis R-HSA-169911 7.228585e-01 0.141 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.228585e-01 0.141 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.228585e-01 0.141 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.228585e-01 0.141 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.243124e-01 0.140 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.254130e-01 0.139 0 0
Gene Silencing by RNA R-HSA-211000 7.274830e-01 0.138 0 0
Signaling by ERBB4 R-HSA-1236394 7.321757e-01 0.135 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.321757e-01 0.135 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.346909e-01 0.134 0 0
Glycosphingolipid transport R-HSA-9845576 7.347407e-01 0.134 0 0
FLT3 signaling in disease R-HSA-9682385 7.347407e-01 0.134 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.347407e-01 0.134 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.352618e-01 0.134 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.370246e-01 0.133 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.370246e-01 0.133 0 0
Choline catabolism R-HSA-6798163 7.370246e-01 0.133 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.370246e-01 0.133 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.370246e-01 0.133 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.370246e-01 0.133 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.396126e-01 0.131 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.402596e-01 0.131 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.433590e-01 0.129 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.435096e-01 0.129 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.448294e-01 0.128 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.461862e-01 0.127 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.461862e-01 0.127 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.461862e-01 0.127 1 1
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.525265e-01 0.123 0 0
GAB1 signalosome R-HSA-180292 7.525265e-01 0.123 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.525265e-01 0.123 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.525265e-01 0.123 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.525265e-01 0.123 0 0
Mismatch Repair R-HSA-5358508 7.525265e-01 0.123 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.525265e-01 0.123 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.525265e-01 0.123 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.525265e-01 0.123 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.551835e-01 0.122 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.572050e-01 0.121 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.595082e-01 0.119 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.621623e-01 0.118 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.621623e-01 0.118 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.671154e-01 0.115 0 0
Pyrimidine biosynthesis R-HSA-500753 7.671154e-01 0.115 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.671154e-01 0.115 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.671154e-01 0.115 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.671154e-01 0.115 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.671154e-01 0.115 0 0
Diseases of hemostasis R-HSA-9671793 7.671154e-01 0.115 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.671154e-01 0.115 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.678078e-01 0.115 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.678078e-01 0.115 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 7.678078e-01 0.115 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.678078e-01 0.115 0 0
RAS processing R-HSA-9648002 7.678078e-01 0.115 0 0
Aggrephagy R-HSA-9646399 7.780053e-01 0.109 0 0
rRNA processing in the mitochondrion R-HSA-8868766 7.780053e-01 0.109 0 0
PKR-mediated signaling R-HSA-9833482 7.801758e-01 0.108 0 0
Kinesins R-HSA-983189 7.803591e-01 0.108 0 0
tRNA Aminoacylation R-HSA-379724 7.803591e-01 0.108 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.808452e-01 0.107 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.808452e-01 0.107 0 0
Protein hydroxylation R-HSA-9629569 7.808452e-01 0.107 0 0
Nephrin family interactions R-HSA-373753 7.808452e-01 0.107 0 0
Glycogen synthesis R-HSA-3322077 7.808452e-01 0.107 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.835709e-01 0.106 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.878083e-01 0.104 0 0
Maturation of spike protein R-HSA-9694548 7.878083e-01 0.104 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.885769e-01 0.103 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.885769e-01 0.103 0 0
Aquaporin-mediated transport R-HSA-445717 7.885769e-01 0.103 0 0
Interferon alpha/beta signaling R-HSA-909733 7.934756e-01 0.100 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.937662e-01 0.100 0 0
G-protein activation R-HSA-202040 7.937662e-01 0.100 0 0
Signalling to RAS R-HSA-167044 7.937662e-01 0.100 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.937662e-01 0.100 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.937662e-01 0.100 1 1
Lagging Strand Synthesis R-HSA-69186 7.937662e-01 0.100 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.937662e-01 0.100 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.937662e-01 0.100 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.937662e-01 0.100 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.937662e-01 0.100 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.965378e-01 0.099 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.965378e-01 0.099 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.965378e-01 0.099 0 0
Signaling by PDGF R-HSA-186797 7.965378e-01 0.099 0 0
mRNA Splicing R-HSA-72172 7.974329e-01 0.098 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.014868e-01 0.096 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.042466e-01 0.095 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.047839e-01 0.094 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.059262e-01 0.094 0 0
Attachment and Entry R-HSA-9694614 8.059262e-01 0.094 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.059262e-01 0.094 1 1
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.059262e-01 0.094 0 0
Glutathione synthesis and recycling R-HSA-174403 8.059262e-01 0.094 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.062754e-01 0.094 0 0
Post-translational protein modification R-HSA-597592 8.103604e-01 0.091 1 0
Insulin receptor signalling cascade R-HSA-74751 8.117083e-01 0.091 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.149617e-01 0.089 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.173699e-01 0.088 0 0
LDL clearance R-HSA-8964038 8.173699e-01 0.088 0 0
PPARA activates gene expression R-HSA-1989781 8.226523e-01 0.085 0 0
RMTs methylate histone arginines R-HSA-3214858 8.232979e-01 0.084 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.266234e-01 0.083 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.281395e-01 0.082 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.281395e-01 0.082 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.281395e-01 0.082 0 0
Biosynthesis of maresins R-HSA-9018682 8.281395e-01 0.082 0 0
Formation of the ureteric bud R-HSA-9830674 8.281395e-01 0.082 0 0
Carnitine shuttle R-HSA-200425 8.281395e-01 0.082 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.312952e-01 0.080 0 0
Somitogenesis R-HSA-9824272 8.312952e-01 0.080 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.314263e-01 0.080 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.314263e-01 0.080 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.318117e-01 0.080 0 0
HIV Life Cycle R-HSA-162587 8.318117e-01 0.080 0 0
Kidney development R-HSA-9830369 8.326618e-01 0.080 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.336488e-01 0.079 0 0
rRNA processing R-HSA-72312 8.357617e-01 0.078 0 0
Cellular response to starvation R-HSA-9711097 8.362508e-01 0.078 0 0
CYP2E1 reactions R-HSA-211999 8.382746e-01 0.077 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.382746e-01 0.077 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.382746e-01 0.077 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.382746e-01 0.077 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.382746e-01 0.077 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.382746e-01 0.077 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.382746e-01 0.077 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.382746e-01 0.077 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.389645e-01 0.076 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.391866e-01 0.076 0 0
ER-Phagosome pathway R-HSA-1236974 8.447214e-01 0.073 0 0
G protein gated Potassium channels R-HSA-1296059 8.478126e-01 0.072 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.478126e-01 0.072 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.478126e-01 0.072 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.478126e-01 0.072 0 0
Hyaluronan degradation R-HSA-2160916 8.478126e-01 0.072 0 0
Fertilization R-HSA-1187000 8.478126e-01 0.072 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.478126e-01 0.072 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.478126e-01 0.072 0 0
Interleukin-7 signaling R-HSA-1266695 8.478126e-01 0.072 0 0
Intraflagellar transport R-HSA-5620924 8.533625e-01 0.069 0 0
NGF-stimulated transcription R-HSA-9031628 8.533625e-01 0.069 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.555152e-01 0.068 0 0
MET activates PTK2 signaling R-HSA-8874081 8.567886e-01 0.067 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.567886e-01 0.067 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.567886e-01 0.067 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.567886e-01 0.067 0 0
Sphingolipid catabolism R-HSA-9845614 8.567886e-01 0.067 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.569180e-01 0.067 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.574566e-01 0.067 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.574566e-01 0.067 0 0
Metabolism of cofactors R-HSA-8978934 8.574566e-01 0.067 0 0
Phospholipid metabolism R-HSA-1483257 8.584104e-01 0.066 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.599956e-01 0.066 0 0
Gap junction trafficking and regulation R-HSA-157858 8.601124e-01 0.065 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 8.601124e-01 0.065 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.647514e-01 0.063 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.652357e-01 0.063 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.652357e-01 0.063 0 0
Cristae formation R-HSA-8949613 8.652357e-01 0.063 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.652357e-01 0.063 0 0
Triglyceride biosynthesis R-HSA-75109 8.652357e-01 0.063 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.652357e-01 0.063 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.652357e-01 0.063 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.652357e-01 0.063 0 0
Signaling by BMP R-HSA-201451 8.652357e-01 0.063 0 0
PI3K Cascade R-HSA-109704 8.665767e-01 0.062 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.686036e-01 0.061 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.705054e-01 0.060 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.705054e-01 0.060 0 0
The phototransduction cascade R-HSA-2514856 8.727658e-01 0.059 0 0
HIV elongation arrest and recovery R-HSA-167287 8.731850e-01 0.059 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.731850e-01 0.059 0 0
Pyroptosis R-HSA-5620971 8.731850e-01 0.059 0 0
Signaling by FGFR in disease R-HSA-1226099 8.738832e-01 0.059 0 0
mRNA 3'-end processing R-HSA-72187 8.786895e-01 0.056 0 0
Orc1 removal from chromatin R-HSA-68949 8.786895e-01 0.056 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.786895e-01 0.056 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.786895e-01 0.056 0 0
Late endosomal microautophagy R-HSA-9615710 8.806659e-01 0.055 0 0
Thyroxine biosynthesis R-HSA-209968 8.806659e-01 0.055 0 0
Potential therapeutics for SARS R-HSA-9679191 8.828382e-01 0.054 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.838816e-01 0.054 0 0
Circadian clock R-HSA-9909396 8.841788e-01 0.053 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.877060e-01 0.052 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.877060e-01 0.052 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.897261e-01 0.051 0 0
DNA Replication R-HSA-69306 8.930404e-01 0.049 0 0
PCP/CE pathway R-HSA-4086400 8.931671e-01 0.049 0 0
ABC transporter disorders R-HSA-5619084 8.931671e-01 0.049 0 0
RNA Polymerase I Transcription R-HSA-73864 8.931671e-01 0.049 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.943310e-01 0.049 0 0
Budding and maturation of HIV virion R-HSA-162588 8.943310e-01 0.049 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.943310e-01 0.049 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.943310e-01 0.049 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.943310e-01 0.049 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.949650e-01 0.048 0 0
Peptide hormone metabolism R-HSA-2980736 8.982979e-01 0.047 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.005657e-01 0.045 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.005657e-01 0.045 0 0
DNA strand elongation R-HSA-69190 9.005657e-01 0.045 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.017808e-01 0.045 0 0
IRS-mediated signalling R-HSA-112399 9.046613e-01 0.044 0 0
Synthesis of PA R-HSA-1483166 9.046613e-01 0.044 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.064328e-01 0.043 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.091896e-01 0.041 0 0
Striated Muscle Contraction R-HSA-390522 9.119540e-01 0.040 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.119540e-01 0.040 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.119540e-01 0.040 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.119540e-01 0.040 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.119540e-01 0.040 0 0
Heme degradation R-HSA-189483 9.119540e-01 0.040 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.135158e-01 0.039 0 0
Signal amplification R-HSA-392518 9.171498e-01 0.038 0 0
Hyaluronan metabolism R-HSA-2142845 9.171498e-01 0.038 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.171498e-01 0.038 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.171498e-01 0.038 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.171498e-01 0.038 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.171498e-01 0.038 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.176481e-01 0.037 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.176481e-01 0.037 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.176481e-01 0.037 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.176481e-01 0.037 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.176481e-01 0.037 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.176481e-01 0.037 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.215942e-01 0.035 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.215942e-01 0.035 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.220301e-01 0.035 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.220392e-01 0.035 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.220392e-01 0.035 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.266404e-01 0.033 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.288816e-01 0.032 0 0
Synthesis of DNA R-HSA-69239 9.297206e-01 0.032 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.302985e-01 0.031 0 0
Pyruvate metabolism R-HSA-70268 9.302985e-01 0.031 0 0
Degradation of DVL R-HSA-4641258 9.309703e-01 0.031 0 0
Degradation of AXIN R-HSA-4641257 9.309703e-01 0.031 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.309703e-01 0.031 0 0
NCAM1 interactions R-HSA-419037 9.309703e-01 0.031 0 0
Metabolism of folate and pterines R-HSA-196757 9.309703e-01 0.031 0 0
Lysine catabolism R-HSA-71064 9.309703e-01 0.031 0 0
Xenobiotics R-HSA-211981 9.323900e-01 0.030 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.387887e-01 0.027 0 0
Neurotransmitter release cycle R-HSA-112310 9.388687e-01 0.027 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.388792e-01 0.027 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.388792e-01 0.027 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.388792e-01 0.027 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.388792e-01 0.027 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.417683e-01 0.026 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.424873e-01 0.026 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.424873e-01 0.026 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.424873e-01 0.026 0 0
HIV Transcription Elongation R-HSA-167169 9.424873e-01 0.026 0 0
Attenuation phase R-HSA-3371568 9.424873e-01 0.026 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.424873e-01 0.026 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.446098e-01 0.025 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.446974e-01 0.025 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.458827e-01 0.024 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.458827e-01 0.024 0 0
Signaling by Insulin receptor R-HSA-74752 9.464549e-01 0.024 0 0
Protein folding R-HSA-391251 9.464549e-01 0.024 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.490778e-01 0.023 0 0
Translation of Structural Proteins R-HSA-9683701 9.490778e-01 0.023 0 0
Heme biosynthesis R-HSA-189451 9.490778e-01 0.023 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.499014e-01 0.022 0 0
Collagen formation R-HSA-1474290 9.510159e-01 0.022 0 0
Activation of GABAB receptors R-HSA-991365 9.520845e-01 0.021 0 0
GABA B receptor activation R-HSA-977444 9.520845e-01 0.021 0 0
Metabolism of porphyrins R-HSA-189445 9.523629e-01 0.021 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.529969e-01 0.021 0 0
Gap junction trafficking R-HSA-190828 9.575762e-01 0.019 0 0
Proteasome assembly R-HSA-9907900 9.575762e-01 0.019 0 0
Methylation R-HSA-156581 9.575762e-01 0.019 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.600815e-01 0.018 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.600815e-01 0.018 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.600815e-01 0.018 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.600815e-01 0.018 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.608808e-01 0.017 0 0
Protein ubiquitination R-HSA-8852135 9.611006e-01 0.017 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.624390e-01 0.017 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.624390e-01 0.017 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.624390e-01 0.017 0 0
UCH proteinases R-HSA-5689603 9.630320e-01 0.016 0 0
Cellular response to heat stress R-HSA-3371556 9.633167e-01 0.016 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.646574e-01 0.016 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.646574e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9694635 9.648711e-01 0.016 0 0
Integrin cell surface interactions R-HSA-216083 9.666220e-01 0.015 0 0
Metal ion SLC transporters R-HSA-425410 9.667450e-01 0.015 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.667450e-01 0.015 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.673953e-01 0.014 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.673953e-01 0.014 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.677368e-01 0.014 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.682889e-01 0.014 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.705577e-01 0.013 0 0
HSF1-dependent transactivation R-HSA-3371571 9.722971e-01 0.012 0 0
tRNA processing R-HSA-72306 9.723632e-01 0.012 0 0
Viral Infection Pathways R-HSA-9824446 9.735006e-01 0.012 1 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.739338e-01 0.011 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.739338e-01 0.011 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.741890e-01 0.011 0 0
Parasitic Infection Pathways R-HSA-9824443 9.743661e-01 0.011 0 0
Leishmania infection R-HSA-9658195 9.743661e-01 0.011 0 0
HCMV Early Events R-HSA-9609690 9.754721e-01 0.011 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.754738e-01 0.011 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.754738e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.754738e-01 0.011 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.754894e-01 0.011 0 0
G alpha (i) signalling events R-HSA-418594 9.762528e-01 0.010 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.769230e-01 0.010 0 0
Translation R-HSA-72766 9.773165e-01 0.010 0 0
HDACs deacetylate histones R-HSA-3214815 9.782866e-01 0.010 0 0
Paracetamol ADME R-HSA-9753281 9.782866e-01 0.010 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.790217e-01 0.009 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.790217e-01 0.009 0 0
Antimicrobial peptides R-HSA-6803157 9.794869e-01 0.009 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.795698e-01 0.009 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.795698e-01 0.009 0 0
Extracellular matrix organization R-HSA-1474244 9.797160e-01 0.009 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.804273e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.807772e-01 0.008 0 0
Dual incision in TC-NER R-HSA-6782135 9.819132e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.829823e-01 0.007 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.829823e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.829823e-01 0.007 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.830077e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.839882e-01 0.007 0 0
Glutathione conjugation R-HSA-156590 9.839882e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.839882e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.839882e-01 0.007 0 0
Endogenous sterols R-HSA-211976 9.849346e-01 0.007 0 0
Parasite infection R-HSA-9664407 9.857436e-01 0.006 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.857436e-01 0.006 0 0
Leishmania phagocytosis R-HSA-9664417 9.857436e-01 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.858252e-01 0.006 0 0
Mitochondrial protein import R-HSA-1268020 9.858252e-01 0.006 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.863596e-01 0.006 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.866632e-01 0.006 0 0
Mitochondrial protein degradation R-HSA-9837999 9.869050e-01 0.006 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.881937e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.888237e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.899545e-01 0.004 0 0
Transcription of the HIV genome R-HSA-167172 9.901667e-01 0.004 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.903116e-01 0.004 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.906049e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.906049e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.909607e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.912954e-01 0.004 0 0
Transport of small molecules R-HSA-382551 9.914776e-01 0.004 0 0
Metal ion assimilation from the host R-HSA-9638482 9.918103e-01 0.004 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.922947e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.927505e-01 0.003 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.930770e-01 0.003 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.931794e-01 0.003 0 0
Nucleotide Excision Repair R-HSA-5696398 9.934379e-01 0.003 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.935829e-01 0.003 0 0
HCMV Late Events R-HSA-9610379 9.936524e-01 0.003 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.938261e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.947152e-01 0.002 1 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.954069e-01 0.002 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.955497e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.965634e-01 0.001 0 0
Disease R-HSA-1643685 9.966579e-01 0.001 1 0
HCMV Infection R-HSA-9609646 9.970600e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.978484e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.981064e-01 0.001 0 0
Scavenging of heme from plasma R-HSA-2168880 9.984234e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.987652e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.991441e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.994069e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.995260e-01 0.000 0 0
Protein localization R-HSA-9609507 9.996609e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997322e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.998290e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998455e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998612e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998793e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998802e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998878e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999455e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999464e-01 0.000 1 0
Peptide ligand-binding receptors R-HSA-375276 9.999502e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999645e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999673e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999686e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999686e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999773e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999788e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999940e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999959e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999962e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999973e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999976e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999978e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999987e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999988e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999991e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999995e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999995e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999998e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 2.220446e-16 15.654 0 0
M Phase R-HSA-68886 1.785239e-13 12.748 0 0
Cellular responses to stimuli R-HSA-8953897 2.147171e-11 10.668 0 0
Cellular responses to stress R-HSA-2262752 3.465195e-11 10.460 0 0
Cell Cycle Checkpoints R-HSA-69620 4.480916e-11 10.349 0 0
Cellular response to heat stress R-HSA-3371556 7.838672e-10 9.106 0 0
Cellular Senescence R-HSA-2559583 1.330468e-09 8.876 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.232175e-08 7.909 0 0
Mitotic Anaphase R-HSA-68882 1.427791e-08 7.845 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.676968e-08 7.775 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.560409e-08 7.592 0 0
Apoptotic execution phase R-HSA-75153 1.312044e-07 6.882 0 0
Mitotic Prometaphase R-HSA-68877 1.498573e-07 6.824 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.013686e-07 6.696 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.246344e-07 6.649 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.246344e-07 6.649 0 0
Metabolism of RNA R-HSA-8953854 2.888629e-07 6.539 0 0
Cell-Cell communication R-HSA-1500931 3.934053e-07 6.405 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.505356e-07 6.346 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.505356e-07 6.346 0 0
Mitotic Prophase R-HSA-68875 4.979814e-07 6.303 0 0
Translation initiation complex formation R-HSA-72649 5.207683e-07 6.283 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.372655e-07 6.270 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.166404e-07 6.145 0 0
Chromatin organization R-HSA-4839726 8.180011e-07 6.087 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.242594e-06 5.906 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.349525e-06 5.870 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.349525e-06 5.870 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.674764e-06 5.776 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.674764e-06 5.776 0 0
DNA Double Strand Break Response R-HSA-5693606 2.070894e-06 5.684 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.306390e-06 5.637 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.768376e-06 5.558 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.885090e-06 5.540 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.781772e-06 5.422 0 0
G2/M Checkpoints R-HSA-69481 4.929558e-06 5.307 0 0
Separation of Sister Chromatids R-HSA-2467813 5.781232e-06 5.238 0 0
Chromatin modifying enzymes R-HSA-3247509 6.143611e-06 5.212 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.086770e-05 4.964 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.299259e-05 4.886 0 0
Influenza Infection R-HSA-168255 1.320074e-05 4.879 0 0
Cell junction organization R-HSA-446728 1.327361e-05 4.877 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.419243e-05 4.848 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.413144e-05 4.850 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.497085e-05 4.825 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.619490e-05 4.791 0 0
ESR-mediated signaling R-HSA-8939211 1.625895e-05 4.789 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.071725e-05 4.684 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.071725e-05 4.684 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.019224e-05 4.695 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.099782e-05 4.678 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.269154e-05 4.644 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.300127e-05 4.638 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.300127e-05 4.638 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.645234e-05 4.578 0 0
Axon guidance R-HSA-422475 2.671699e-05 4.573 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.854405e-05 4.544 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.072358e-05 4.513 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.264794e-05 4.486 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.410885e-05 4.467 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.558097e-05 4.449 0 0
Apoptosis R-HSA-109581 3.592548e-05 4.445 0 0
Adherens junctions interactions R-HSA-418990 3.850954e-05 4.414 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.931438e-05 4.405 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.577159e-05 4.339 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.554162e-05 4.342 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.672176e-05 4.330 0 0
Nervous system development R-HSA-9675108 4.571121e-05 4.340 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.741615e-05 4.324 0 0
mRNA Splicing R-HSA-72172 4.800511e-05 4.319 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.119039e-05 4.213 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.262755e-05 4.203 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.739510e-05 4.241 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.260241e-05 4.203 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.140348e-05 4.212 0 0
Signaling by ALK in cancer R-HSA-9700206 6.260241e-05 4.203 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.262755e-05 4.203 0 0
Signal Transduction R-HSA-162582 6.631357e-05 4.178 1 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.643978e-05 4.117 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.968859e-05 4.099 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.266243e-05 4.083 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.915224e-05 4.102 0 0
Regulation of CDH1 Function R-HSA-9764561 8.317872e-05 4.080 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.597536e-05 4.066 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.085660e-04 3.964 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.085660e-04 3.964 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.100518e-04 3.958 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.118929e-04 3.951 0 0
Homology Directed Repair R-HSA-5693538 1.021939e-04 3.991 0 0
Nuclear import of Rev protein R-HSA-180746 1.104980e-04 3.957 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.068225e-04 3.971 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.071351e-04 3.970 0 0
G2/M Transition R-HSA-69275 1.140317e-04 3.943 0 0
Host Interactions of HIV factors R-HSA-162909 1.181454e-04 3.928 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.431060e-04 3.844 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.431060e-04 3.844 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.441847e-04 3.841 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.549777e-04 3.810 0 0
Programmed Cell Death R-HSA-5357801 1.755372e-04 3.756 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.824725e-04 3.739 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.947351e-04 3.711 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.947351e-04 3.711 0 0
Cell-cell junction organization R-HSA-421270 2.165988e-04 3.664 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.282664e-04 3.642 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.290798e-04 3.640 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.372969e-04 3.625 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.435330e-04 3.613 0 0
Gene expression (Transcription) R-HSA-74160 2.473482e-04 3.607 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.693323e-04 3.570 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.566882e-04 3.591 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.217216e-04 3.493 0 0
Metabolism of non-coding RNA R-HSA-194441 3.228126e-04 3.491 0 0
snRNP Assembly R-HSA-191859 3.228126e-04 3.491 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.279417e-04 3.484 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.399617e-04 3.469 1 0
Cytokine Signaling in Immune system R-HSA-1280215 3.473957e-04 3.459 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.725581e-04 3.429 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.705354e-04 3.431 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.747383e-04 3.426 0 0
Signaling by ROBO receptors R-HSA-376176 3.963648e-04 3.402 0 0
HSF1-dependent transactivation R-HSA-3371571 3.983012e-04 3.400 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.208444e-04 3.376 0 0
Peptide chain elongation R-HSA-156902 4.265023e-04 3.370 0 0
EPH-Ephrin signaling R-HSA-2682334 4.321438e-04 3.364 0 0
Oncogene Induced Senescence R-HSA-2559585 4.331474e-04 3.363 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.515870e-04 3.345 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.666044e-04 3.331 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.793215e-04 3.319 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.424681e-04 3.266 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.464148e-04 3.262 0 0
Ephrin signaling R-HSA-3928664 5.464148e-04 3.262 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.091530e-04 3.215 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.091530e-04 3.215 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.283840e-04 3.202 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.522487e-04 3.186 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.697978e-04 3.114 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.459694e-04 3.073 0 0
Interferon Signaling R-HSA-913531 9.112210e-04 3.040 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.001739e-03 2.999 0 0
S Phase R-HSA-69242 1.046809e-03 2.980 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.005079e-03 2.998 0 0
Signaling by WNT R-HSA-195721 1.051709e-03 2.978 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.153265e-03 2.938 0 0
MAP kinase activation R-HSA-450294 1.112374e-03 2.954 1 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.111004e-03 2.954 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.126147e-03 2.948 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.182502e-03 2.927 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.321517e-03 2.879 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.445624e-03 2.840 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.563391e-03 2.806 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.563391e-03 2.806 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.619329e-03 2.791 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.699504e-03 2.770 1 0
ALK mutants bind TKIs R-HSA-9700645 1.814625e-03 2.741 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.848215e-03 2.733 0 0
Nucleosome assembly R-HSA-774815 1.848215e-03 2.733 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.848215e-03 2.733 0 0
Ribosome-associated quality control R-HSA-9948299 1.837055e-03 2.736 0 0
HDMs demethylate histones R-HSA-3214842 1.877193e-03 2.726 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.801244e-03 2.744 1 0
p75NTR signals via NF-kB R-HSA-193639 1.799867e-03 2.745 1 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.932466e-03 2.714 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.932466e-03 2.714 0 0
Nef and signal transduction R-HSA-164944 1.970240e-03 2.705 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.033405e-03 2.692 0 0
Regulation of TP53 Activity R-HSA-5633007 2.048408e-03 2.689 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.286203e-03 2.641 0 0
Protein ubiquitination R-HSA-8852135 2.187271e-03 2.660 0 0
Centrosome maturation R-HSA-380287 2.187271e-03 2.660 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.099768e-03 2.678 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.099768e-03 2.678 0 0
Signaling by ERBB2 R-HSA-1227986 2.120416e-03 2.674 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.260273e-03 2.646 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.154532e-03 2.667 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.308652e-03 2.637 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.308652e-03 2.637 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.308652e-03 2.637 1 0
p75NTR recruits signalling complexes R-HSA-209543 2.286203e-03 2.641 1 1
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.233789e-03 2.651 0 0
Gene Silencing by RNA R-HSA-211000 2.172447e-03 2.663 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.417672e-03 2.617 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.689479e-03 2.570 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.689479e-03 2.570 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.689479e-03 2.570 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.689479e-03 2.570 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.584682e-03 2.588 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.584682e-03 2.588 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.799225e-03 2.553 0 0
mRNA 3'-end processing R-HSA-72187 2.799225e-03 2.553 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.762662e-03 2.559 0 0
HATs acetylate histones R-HSA-3214847 2.615140e-03 2.583 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.819523e-03 2.550 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.527007e-03 2.597 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.819523e-03 2.550 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.848577e-03 2.545 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.923882e-03 2.534 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.091732e-03 2.510 1 0
MyD88-independent TLR4 cascade R-HSA-166166 3.091732e-03 2.510 1 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.190988e-03 2.496 0 0
Post NMDA receptor activation events R-HSA-438064 3.221752e-03 2.492 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.305575e-03 2.481 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.415131e-03 2.467 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.447729e-03 2.462 0 0
Nephrin family interactions R-HSA-373753 3.447729e-03 2.462 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.451447e-03 2.462 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.451447e-03 2.462 0 0
Attenuation phase R-HSA-3371568 3.463557e-03 2.460 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.467116e-03 2.460 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.668643e-03 2.435 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.668643e-03 2.435 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.908916e-03 2.408 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.908916e-03 2.408 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.384875e-03 2.358 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.042227e-03 2.393 0 0
Interleukin-17 signaling R-HSA-448424 4.550317e-03 2.342 1 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.266905e-03 2.370 0 0
HIV Life Cycle R-HSA-162587 4.418443e-03 2.355 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.323066e-03 2.364 1 0
ChREBP activates metabolic gene expression R-HSA-163765 4.203944e-03 2.376 0 0
FLT3 Signaling R-HSA-9607240 4.183345e-03 2.378 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.596093e-03 2.338 0 0
Regulation of KIT signaling R-HSA-1433559 4.604865e-03 2.337 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.604865e-03 2.337 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.604865e-03 2.337 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.020587e-03 2.299 0 0
DNA Replication R-HSA-69306 5.123368e-03 2.290 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.195629e-03 2.284 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.195629e-03 2.284 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.247144e-03 2.280 0 0
Meiotic recombination R-HSA-912446 5.308585e-03 2.275 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.310267e-03 2.275 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.374380e-03 2.270 0 0
HIV Infection R-HSA-162906 5.605549e-03 2.251 0 0
Eukaryotic Translation Termination R-HSA-72764 5.746550e-03 2.241 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.817244e-03 2.235 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.881607e-03 2.231 0 0
Dual Incision in GG-NER R-HSA-5696400 6.534904e-03 2.185 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.992781e-03 2.155 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.726164e-03 2.172 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.534904e-03 2.185 0 0
Signaling by NOTCH R-HSA-157118 6.125946e-03 2.213 0 0
NF-kB is activated and signals survival R-HSA-209560 6.049589e-03 2.218 0 0
RNA Polymerase II Transcription R-HSA-73857 7.022558e-03 2.154 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.825501e-03 2.166 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.494457e-03 2.187 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.086048e-03 2.216 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.527269e-03 2.123 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.731673e-03 2.112 0 0
Cellular response to starvation R-HSA-9711097 7.920249e-03 2.101 0 0
Regulation of signaling by CBL R-HSA-912631 7.997860e-03 2.097 0 0
rRNA processing R-HSA-72312 8.013049e-03 2.096 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.088984e-03 2.092 1 0
Oncogenic MAPK signaling R-HSA-6802957 8.182252e-03 2.087 0 0
Meiosis R-HSA-1500620 8.182252e-03 2.087 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.337255e-03 2.079 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.337255e-03 2.079 0 0
Degradation of CDH1 R-HSA-9766229 8.438718e-03 2.074 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.441000e-03 2.074 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.441000e-03 2.074 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.441000e-03 2.074 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.724482e-03 2.059 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.805738e-03 2.055 0 0
Membrane Trafficking R-HSA-199991 8.942716e-03 2.049 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.957742e-03 2.048 1 0
Diseases of mitotic cell cycle R-HSA-9675126 9.005184e-03 2.046 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.093112e-02 1.961 0 0
CREB phosphorylation R-HSA-199920 9.657638e-03 2.015 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.022759e-02 1.990 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.297864e-03 2.032 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.086114e-02 1.964 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.448298e-03 2.025 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.725513e-03 2.012 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.562237e-03 2.019 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.094684e-02 1.961 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.708259e-03 2.013 0 0
DAG and IP3 signaling R-HSA-1489509 9.821536e-03 2.008 0 0
Autophagy R-HSA-9612973 1.079864e-02 1.967 0 0
Selenocysteine synthesis R-HSA-2408557 1.102482e-02 1.958 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.252748e-03 2.034 1 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.119370e-02 1.951 0 0
Josephin domain DUBs R-HSA-5689877 1.121556e-02 1.950 0 0
Pexophagy R-HSA-9664873 1.121556e-02 1.950 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.124256e-02 1.949 1 1
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.136115e-02 1.945 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.145932e-02 1.941 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.145932e-02 1.941 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.145932e-02 1.941 0 0
Signaling by RAS mutants R-HSA-6802949 1.145932e-02 1.941 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.146324e-02 1.941 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.146324e-02 1.941 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.176203e-02 1.930 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.201038e-02 1.920 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.220112e-02 1.914 0 0
Late endosomal microautophagy R-HSA-9615710 1.244188e-02 1.905 0 0
tRNA processing in the nucleus R-HSA-6784531 1.248611e-02 1.904 0 0
Signaling by Interleukins R-HSA-449147 1.287982e-02 1.890 1 0
SARS-CoV Infections R-HSA-9679506 1.294794e-02 1.888 1 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.299906e-02 1.886 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.311219e-02 1.882 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.330355e-02 1.876 0 0
MTOR signalling R-HSA-165159 1.337568e-02 1.874 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.337568e-02 1.874 0 0
Viral mRNA Translation R-HSA-192823 1.347653e-02 1.870 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.350043e-02 1.870 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.415868e-02 1.849 1 1
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.419132e-02 1.848 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.460632e-02 1.835 0 0
Regulation of PTEN localization R-HSA-8948747 1.460632e-02 1.835 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.505372e-02 1.822 0 0
Smooth Muscle Contraction R-HSA-445355 1.505372e-02 1.822 0 0
PECAM1 interactions R-HSA-210990 1.558210e-02 1.807 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.558210e-02 1.807 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.604734e-02 1.795 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.604734e-02 1.795 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.604734e-02 1.795 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.625471e-02 1.789 0 0
DNA Repair R-HSA-73894 1.663351e-02 1.779 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.968049e-02 1.706 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.816173e-02 1.741 0 0
Type I hemidesmosome assembly R-HSA-446107 2.101835e-02 1.677 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.101835e-02 1.677 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.101835e-02 1.677 0 0
Formation of annular gap junctions R-HSA-196025 2.101835e-02 1.677 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.972902e-02 1.705 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.972902e-02 1.705 0 0
mTORC1-mediated signalling R-HSA-166208 1.973021e-02 1.705 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.076737e-02 1.683 0 0
Aggrephagy R-HSA-9646399 1.823289e-02 1.739 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.823289e-02 1.739 0 0
HDACs deacetylate histones R-HSA-3214815 1.959850e-02 1.708 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.837247e-02 1.736 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.077708e-02 1.682 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.948715e-02 1.710 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.906382e-02 1.720 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.100287e-02 1.678 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.731979e-02 1.761 0 0
Macroautophagy R-HSA-1632852 1.919120e-02 1.717 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.100287e-02 1.678 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.101835e-02 1.677 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.100287e-02 1.678 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.972902e-02 1.705 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.972902e-02 1.705 0 0
PERK regulates gene expression R-HSA-381042 1.822290e-02 1.739 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.101835e-02 1.677 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.972902e-02 1.705 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.101835e-02 1.677 0 0
Interleukin-12 signaling R-HSA-9020591 1.856091e-02 1.731 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.117107e-02 1.674 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.117107e-02 1.674 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.126145e-02 1.672 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.133207e-02 1.671 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.133783e-02 1.671 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.133783e-02 1.671 0 0
HSF1 activation R-HSA-3371511 2.135956e-02 1.670 0 0
Calmodulin induced events R-HSA-111933 2.135956e-02 1.670 0 0
CaM pathway R-HSA-111997 2.135956e-02 1.670 0 0
Synthesis of DNA R-HSA-69239 2.154096e-02 1.667 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.208560e-02 1.656 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.240345e-02 1.650 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.240345e-02 1.650 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.290118e-02 1.640 0 0
RNA Polymerase I Transcription R-HSA-73864 2.302257e-02 1.638 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.382557e-02 1.623 0 0
Diseases of DNA repair R-HSA-9675135 2.382557e-02 1.623 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.398774e-02 1.620 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.401700e-02 1.619 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.412071e-02 1.618 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.487915e-02 1.604 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.487915e-02 1.604 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.503143e-02 1.602 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.503143e-02 1.602 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.507237e-02 1.601 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.512473e-02 1.600 0 0
Phosphorylation of the APC/C R-HSA-176412 2.512473e-02 1.600 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.299784e-02 1.482 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.299784e-02 1.482 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.299784e-02 1.482 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.299784e-02 1.482 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.299784e-02 1.482 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 3.299784e-02 1.482 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 3.299784e-02 1.482 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 3.299784e-02 1.482 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.299784e-02 1.482 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.299784e-02 1.482 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.780340e-02 1.556 0 0
Gap junction degradation R-HSA-190873 2.903038e-02 1.537 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.757432e-02 1.559 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.757432e-02 1.559 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.145170e-02 1.502 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.145170e-02 1.502 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.757612e-02 1.559 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.352167e-02 1.475 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.352167e-02 1.475 0 0
Deadenylation of mRNA R-HSA-429947 2.886136e-02 1.540 0 0
DNA methylation R-HSA-5334118 2.934063e-02 1.533 0 0
Striated Muscle Contraction R-HSA-390522 2.926403e-02 1.534 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.619185e-02 1.582 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.961599e-02 1.528 0 0
Meiotic synapsis R-HSA-1221632 2.961599e-02 1.528 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.314123e-02 1.480 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.934063e-02 1.533 0 0
Chromosome Maintenance R-HSA-73886 3.121585e-02 1.506 0 0
GPER1 signaling R-HSA-9634597 3.090339e-02 1.510 0 0
Deubiquitination R-HSA-5688426 3.274917e-02 1.485 1 0
GP1b-IX-V activation signalling R-HSA-430116 2.903038e-02 1.537 0 0
G1/S Transition R-HSA-69206 2.919689e-02 1.535 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.661986e-02 1.575 1 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.826262e-02 1.549 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.661986e-02 1.575 1 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.145170e-02 1.502 0 0
Neurexins and neuroligins R-HSA-6794361 2.619185e-02 1.582 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.757432e-02 1.559 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.737003e-02 1.563 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.737003e-02 1.563 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.145170e-02 1.502 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.903038e-02 1.537 0 0
Signaling by NOTCH4 R-HSA-9013694 2.701903e-02 1.568 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.145170e-02 1.502 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.886136e-02 1.540 0 0
Defective pyroptosis R-HSA-9710421 3.210525e-02 1.493 0 0
Signaling by VEGF R-HSA-194138 2.919689e-02 1.535 0 0
Semaphorin interactions R-HSA-373755 2.694272e-02 1.570 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.826262e-02 1.549 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.780340e-02 1.556 0 0
L1CAM interactions R-HSA-373760 3.338164e-02 1.476 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.903038e-02 1.537 0 0
Negative regulation of MET activity R-HSA-6807004 2.757612e-02 1.559 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.671094e-02 1.573 1 0
Glycolysis R-HSA-70171 2.918975e-02 1.535 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.145170e-02 1.502 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.808701e-02 1.551 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.335856e-02 1.477 0 0
Inositol phosphate metabolism R-HSA-1483249 3.295626e-02 1.482 0 0
Maturation of protein E R-HSA-9694493 2.780340e-02 1.556 0 0
Maturation of protein E R-HSA-9683683 2.780340e-02 1.556 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.372942e-02 1.472 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.372942e-02 1.472 1 0
Long-term potentiation R-HSA-9620244 3.438916e-02 1.464 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.445495e-02 1.463 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.453727e-02 1.462 1 0
Regulation of endogenous retroelements R-HSA-9842860 3.466728e-02 1.460 0 0
DNA Damage Bypass R-HSA-73893 3.496709e-02 1.456 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.496709e-02 1.456 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.518330e-02 1.454 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.518330e-02 1.454 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.537667e-02 1.451 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.537667e-02 1.451 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.537667e-02 1.451 0 0
Interleukin-12 family signaling R-HSA-447115 3.539960e-02 1.451 0 0
Kinesins R-HSA-983189 3.548657e-02 1.450 0 0
G1 Phase R-HSA-69236 3.652247e-02 1.437 0 0
Cyclin D associated events in G1 R-HSA-69231 3.652247e-02 1.437 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.796788e-02 1.421 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.796788e-02 1.421 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.862410e-02 1.413 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.874329e-02 1.412 0 0
Signal attenuation R-HSA-74749 3.874329e-02 1.412 0 0
Diseases of programmed cell death R-HSA-9645723 3.874805e-02 1.412 0 0
Signaling by Hippo R-HSA-2028269 3.876550e-02 1.412 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.889480e-02 1.410 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.016001e-02 1.396 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.023605e-02 1.395 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.028240e-02 1.395 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.060523e-02 1.391 0 0
G-protein mediated events R-HSA-112040 4.135341e-02 1.383 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.135634e-02 1.383 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.185609e-02 1.378 0 0
Ion homeostasis R-HSA-5578775 4.185609e-02 1.378 0 0
Signaling by EGFR R-HSA-177929 4.185609e-02 1.378 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.199435e-02 1.377 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.288315e-02 1.368 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.447186e-02 1.352 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.447186e-02 1.352 0 0
Co-inhibition by PD-1 R-HSA-389948 4.519382e-02 1.345 0 0
Reproduction R-HSA-1474165 4.539798e-02 1.343 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.559714e-02 1.341 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.613412e-02 1.336 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.662314e-02 1.331 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.711101e-02 1.327 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.711101e-02 1.327 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.711101e-02 1.327 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.711101e-02 1.327 0 0
Hedgehog 'off' state R-HSA-5610787 4.743264e-02 1.324 0 0
Signaling by KIT in disease R-HSA-9669938 4.789381e-02 1.320 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.789381e-02 1.320 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.789381e-02 1.320 0 0
Generic Transcription Pathway R-HSA-212436 4.812472e-02 1.318 0 0
Integration of energy metabolism R-HSA-163685 4.856962e-02 1.314 0 0
MAP2K and MAPK activation R-HSA-5674135 4.901045e-02 1.310 0 0
Orc1 removal from chromatin R-HSA-68949 4.944506e-02 1.306 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.116049e-02 1.291 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.131763e-02 1.290 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.233758e-02 1.281 0 0
Recycling pathway of L1 R-HSA-437239 5.233758e-02 1.281 0 0
MAPK family signaling cascades R-HSA-5683057 5.259688e-02 1.279 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 6.778121e-02 1.169 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.778121e-02 1.169 0 0
Regulation of gap junction activity R-HSA-191650 5.419985e-02 1.266 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.419985e-02 1.266 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 7.784454e-02 1.109 0 0
IRS activation R-HSA-74713 7.784454e-02 1.109 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.784454e-02 1.109 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.476610e-02 1.261 0 0
Recycling of eIF2:GDP R-HSA-72731 5.476610e-02 1.261 0 0
RSK activation R-HSA-444257 7.209338e-02 1.142 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.348736e-02 1.197 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.348736e-02 1.197 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.348736e-02 1.197 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.490240e-02 1.260 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.853422e-02 1.105 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.853422e-02 1.105 0 0
Pervasive developmental disorders R-HSA-9005895 7.853422e-02 1.105 0 0
Disorders of Nervous System Development R-HSA-9697154 7.853422e-02 1.105 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.853422e-02 1.105 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.853422e-02 1.105 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.853422e-02 1.105 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.853422e-02 1.105 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.853422e-02 1.105 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.853422e-02 1.105 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.669078e-02 1.176 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.652151e-02 1.248 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.701822e-02 1.174 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.701822e-02 1.174 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.701822e-02 1.174 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.701822e-02 1.174 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.577293e-02 1.182 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.365279e-02 1.196 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.365279e-02 1.196 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.365279e-02 1.196 0 0
RAF activation R-HSA-5673000 6.933957e-02 1.159 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.933957e-02 1.159 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.933957e-02 1.159 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.933957e-02 1.159 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.933957e-02 1.159 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.378094e-02 1.132 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.325076e-02 1.199 0 0
PTEN Regulation R-HSA-6807070 5.906237e-02 1.229 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.286498e-02 1.137 0 0
Nucleotide Excision Repair R-HSA-5696398 7.422738e-02 1.129 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.662062e-02 1.176 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.531401e-02 1.257 0 0
Co-stimulation by CD28 R-HSA-389356 5.851268e-02 1.233 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.860998e-02 1.105 0 0
ERK/MAPK targets R-HSA-198753 7.860998e-02 1.105 0 0
DCC mediated attractive signaling R-HSA-418885 5.490240e-02 1.260 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.209338e-02 1.142 0 0
Regulation of Apoptosis R-HSA-169911 7.830329e-02 1.106 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.419985e-02 1.266 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.860998e-02 1.105 0 0
PLC beta mediated events R-HSA-112043 6.957622e-02 1.158 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.171905e-02 1.144 0 0
Selective autophagy R-HSA-9663891 6.336761e-02 1.198 0 0
Ca-dependent events R-HSA-111996 5.528003e-02 1.257 0 0
Opioid Signalling R-HSA-111885 6.435555e-02 1.191 0 0
G alpha (z) signalling events R-HSA-418597 6.762671e-02 1.170 0 0
Signaling by NOTCH3 R-HSA-9012852 6.762671e-02 1.170 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.860998e-02 1.105 1 1
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.378094e-02 1.132 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.669078e-02 1.176 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.521527e-02 1.258 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.490240e-02 1.260 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.652151e-02 1.248 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.531401e-02 1.257 0 0
G alpha (12/13) signalling events R-HSA-416482 6.728414e-02 1.172 0 0
Toll-like Receptor Cascades R-HSA-168898 7.607515e-02 1.119 1 0
Interleukin-1 signaling R-HSA-9020702 7.978335e-02 1.098 1 1
Mitophagy R-HSA-5205647 6.933957e-02 1.159 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.515957e-02 1.186 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.515957e-02 1.186 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.590275e-02 1.253 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.607270e-02 1.119 0 0
NrCAM interactions R-HSA-447038 7.784454e-02 1.109 0 0
Interleukin-7 signaling R-HSA-1266695 7.607270e-02 1.119 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.113641e-02 1.214 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.630796e-02 1.117 0 0
Stabilization of p53 R-HSA-69541 6.570014e-02 1.182 0 0
Muscle contraction R-HSA-397014 6.489878e-02 1.188 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.209338e-02 1.142 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.490240e-02 1.260 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.490240e-02 1.260 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.933957e-02 1.159 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.983965e-02 1.098 0 0
Disorders of Developmental Biology R-HSA-9675151 7.983965e-02 1.098 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.193538e-02 1.087 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.246554e-02 1.084 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.285927e-02 1.082 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.285927e-02 1.082 0 0
EGFR downregulation R-HSA-182971 8.285927e-02 1.082 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.345130e-02 1.079 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.580783e-02 1.066 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.595608e-02 1.066 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.728681e-02 1.059 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.728681e-02 1.059 0 0
Metalloprotease DUBs R-HSA-5689901 8.728681e-02 1.059 0 0
FLT3 signaling in disease R-HSA-9682385 8.795124e-02 1.056 0 0
Dual incision in TC-NER R-HSA-6782135 8.976400e-02 1.047 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.129339e-02 1.040 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.129339e-02 1.040 1 1
Degradation of GLI2 by the proteasome R-HSA-5610783 9.175770e-02 1.037 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.175770e-02 1.037 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.175770e-02 1.037 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.175770e-02 1.037 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.186597e-02 1.037 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.186597e-02 1.037 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 9.186597e-02 1.037 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.186597e-02 1.037 0 0
Unwinding of DNA R-HSA-176974 9.186597e-02 1.037 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.198761e-02 1.036 0 0
Protein folding R-HSA-391251 9.234920e-02 1.035 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.255107e-02 1.034 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.433241e-02 1.025 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.433241e-02 1.025 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.433241e-02 1.025 0 0
Glycogen storage diseases R-HSA-3229121 9.433241e-02 1.025 0 0
Specification of primordial germ cells R-HSA-9827857 9.433241e-02 1.025 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.457378e-02 1.024 1 1
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.531767e-02 1.021 0 0
Maturation of nucleoprotein R-HSA-9683610 9.531767e-02 1.021 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.712972e-02 1.013 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.828397e-02 1.008 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.941054e-02 1.003 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.941054e-02 1.003 0 0
Packaging Of Telomere Ends R-HSA-171306 9.941054e-02 1.003 0 0
TCR signaling R-HSA-202403 1.032535e-01 0.986 1 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.040619e-01 0.983 0 0
Notch-HLH transcription pathway R-HSA-350054 1.050531e-01 0.979 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.050531e-01 0.979 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.051883e-01 0.978 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.051883e-01 0.978 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.051883e-01 0.978 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.051883e-01 0.978 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.051883e-01 0.978 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.051883e-01 0.978 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.051938e-01 0.978 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.051938e-01 0.978 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.051938e-01 0.978 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.075309e-01 0.968 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.076065e-01 0.968 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.076065e-01 0.968 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.092975e-01 0.961 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.101345e-01 0.958 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.101345e-01 0.958 0 0
PKA activation in glucagon signalling R-HSA-164378 1.101345e-01 0.958 0 0
Mismatch Repair R-HSA-5358508 1.101345e-01 0.958 0 0
Diseases of cellular response to stress R-HSA-9675132 1.101363e-01 0.958 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.101363e-01 0.958 0 0
Regulation of TP53 Expression R-HSA-6804754 1.101363e-01 0.958 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.121622e-01 0.950 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 1.124310e-01 0.949 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.132889e-01 0.946 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.137648e-01 0.944 0 0
Malate-aspartate shuttle R-HSA-9856872 1.137648e-01 0.944 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.139217e-01 0.943 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.139217e-01 0.943 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.139217e-01 0.943 0 0
Signaling by Leptin R-HSA-2586552 1.139217e-01 0.943 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.150426e-01 0.939 0 0
Ca2+ pathway R-HSA-4086398 1.160684e-01 0.935 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.198623e-01 0.921 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.198623e-01 0.921 0 0
Growth hormone receptor signaling R-HSA-982772 1.198623e-01 0.921 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.209833e-01 0.917 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.209833e-01 0.917 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.209833e-01 0.917 0 0
Glucose metabolism R-HSA-70326 1.219642e-01 0.914 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.232644e-01 0.909 0 0
PKR-mediated signaling R-HSA-9833482 1.241625e-01 0.906 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.253927e-01 0.902 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.263274e-01 0.899 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.263274e-01 0.899 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.263274e-01 0.899 0 0
Glucagon-type ligand receptors R-HSA-420092 1.263274e-01 0.899 0 0
Translesion Synthesis by POLH R-HSA-110320 1.271945e-01 0.896 0 0
Rap1 signalling R-HSA-392517 1.271945e-01 0.896 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.271945e-01 0.896 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.287449e-01 0.890 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.290512e-01 0.889 0 0
HCMV Early Events R-HSA-9609690 1.300805e-01 0.886 0 0
IRE1alpha activates chaperones R-HSA-381070 1.302820e-01 0.885 0 0
Signaling by NOTCH2 R-HSA-1980145 1.305961e-01 0.884 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.314863e-01 0.881 0 0
KIT mutants bind TKIs R-HSA-9669921 1.314863e-01 0.881 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.314863e-01 0.881 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.314863e-01 0.881 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.314863e-01 0.881 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.314863e-01 0.881 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.314863e-01 0.881 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.314863e-01 0.881 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.314863e-01 0.881 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.314863e-01 0.881 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.314863e-01 0.881 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.314863e-01 0.881 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.317151e-01 0.880 0 0
Viral Infection Pathways R-HSA-9824446 1.329643e-01 0.876 1 0
Amyloid fiber formation R-HSA-977225 1.330148e-01 0.876 0 0
Glycogen metabolism R-HSA-8982491 1.333287e-01 0.875 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.337771e-01 0.874 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.337771e-01 0.874 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.337771e-01 0.874 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.337771e-01 0.874 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.337771e-01 0.874 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.337771e-01 0.874 0 0
Translesion synthesis by REV1 R-HSA-110312 1.337771e-01 0.874 0 0
Formation of the anterior neural plate R-HSA-9823739 1.337771e-01 0.874 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.337771e-01 0.874 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.341440e-01 0.872 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.349542e-01 0.870 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.349542e-01 0.870 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.349542e-01 0.870 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.356836e-01 0.867 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.356836e-01 0.867 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.356869e-01 0.867 0 0
Signaling by PTK6 R-HSA-8848021 1.356869e-01 0.867 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.356967e-01 0.867 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.356967e-01 0.867 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.356967e-01 0.867 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.356967e-01 0.867 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.356967e-01 0.867 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.357631e-01 0.867 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.380552e-01 0.860 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.380552e-01 0.860 0 0
Signaling by APC mutants R-HSA-4839744 1.380552e-01 0.860 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.380552e-01 0.860 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.380552e-01 0.860 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.380552e-01 0.860 0 0
Bicarbonate transporters R-HSA-425381 1.380552e-01 0.860 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.380552e-01 0.860 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.456905e-01 0.610 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.456905e-01 0.610 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.456905e-01 0.610 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.456905e-01 0.610 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.456905e-01 0.610 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.456905e-01 0.610 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.456905e-01 0.610 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.456905e-01 0.610 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.456905e-01 0.610 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.574723e-01 0.803 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.574723e-01 0.803 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.077485e-01 0.682 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.077485e-01 0.682 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.077485e-01 0.682 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.077485e-01 0.682 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.077485e-01 0.682 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.688007e-01 0.773 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.688007e-01 0.773 0 0
SOS-mediated signalling R-HSA-112412 1.688007e-01 0.773 0 0
Disinhibition of SNARE formation R-HSA-114516 1.688007e-01 0.773 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.593741e-01 0.586 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.593741e-01 0.586 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.593741e-01 0.586 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.593741e-01 0.586 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.593741e-01 0.586 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.039295e-01 0.691 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.640302e-01 0.785 0 0
Activation of RAC1 R-HSA-428540 1.640302e-01 0.785 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.552347e-01 0.809 0 0
Translesion synthesis by POLI R-HSA-5656121 1.552347e-01 0.809 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.915903e-01 0.718 0 0
Polymerase switching R-HSA-69091 1.915903e-01 0.718 0 0
Leading Strand Synthesis R-HSA-69109 1.915903e-01 0.718 0 0
Calcineurin activates NFAT R-HSA-2025928 2.405334e-01 0.619 0 0
Translesion synthesis by POLK R-HSA-5655862 1.780011e-01 0.750 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.204684e-01 0.657 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.204684e-01 0.657 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.524700e-01 0.817 0 0
Activation of the pre-replicative complex R-HSA-68962 1.410717e-01 0.851 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.268539e-01 0.644 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.444039e-01 0.840 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.444039e-01 0.840 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.887073e-01 0.724 0 0
Cristae formation R-HSA-8949613 1.887073e-01 0.724 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.741311e-01 0.759 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.077356e-01 0.682 0 0
Signaling by Erythropoietin R-HSA-9006335 2.280438e-01 0.642 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.514923e-01 0.599 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.595062e-01 0.797 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.486846e-01 0.604 0 0
G1/S-Specific Transcription R-HSA-69205 2.643696e-01 0.578 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.587049e-01 0.587 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.317090e-01 0.635 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.178384e-01 0.662 0 0
Signaling by SCF-KIT R-HSA-1433557 1.889049e-01 0.724 0 0
G0 and Early G1 R-HSA-1538133 1.729572e-01 0.762 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.899175e-01 0.721 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.407737e-01 0.618 0 0
Ub-specific processing proteases R-HSA-5689880 1.470214e-01 0.833 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.648120e-01 0.783 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.562571e-01 0.591 0 0
Telomere Maintenance R-HSA-157579 2.699173e-01 0.569 0 0
UCH proteinases R-HSA-5689603 1.437494e-01 0.842 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.915903e-01 0.718 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.019268e-01 0.695 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.363060e-01 0.627 0 0
TGFBR3 expression R-HSA-9839394 1.524700e-01 0.817 0 0
Integrin signaling R-HSA-354192 1.900101e-01 0.721 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.463164e-01 0.835 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.486846e-01 0.604 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.200280e-01 0.658 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.551978e-01 0.809 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.566287e-01 0.805 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.780011e-01 0.750 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.463164e-01 0.835 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.593741e-01 0.586 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.503953e-01 0.601 0 0
DNA strand elongation R-HSA-69190 1.729572e-01 0.762 0 0
Cellular response to hypoxia R-HSA-1234174 2.363692e-01 0.626 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.900101e-01 0.721 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.171970e-01 0.663 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.200280e-01 0.658 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.079474e-01 0.682 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.704544e-01 0.768 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.704544e-01 0.768 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.704544e-01 0.768 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.704544e-01 0.768 0 0
Budding and maturation of HIV virion R-HSA-162588 1.566287e-01 0.805 0 0
Signaling by WNT in cancer R-HSA-4791275 1.729572e-01 0.762 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.589152e-01 0.799 0 0
Platelet calcium homeostasis R-HSA-418360 2.280438e-01 0.642 0 0
Signaling by NOTCH1 R-HSA-1980143 1.437494e-01 0.842 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.450960e-01 0.838 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.431566e-01 0.844 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.444039e-01 0.840 0 0
Degradation of DVL R-HSA-4641258 1.740984e-01 0.759 0 0
Translation R-HSA-72766 1.830379e-01 0.737 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.486846e-01 0.604 0 0
Signal amplification R-HSA-392518 2.260775e-01 0.646 0 0
Vesicle-mediated transport R-HSA-5653656 2.613997e-01 0.583 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.593741e-01 0.586 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.204684e-01 0.657 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.503953e-01 0.601 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.463164e-01 0.835 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.463164e-01 0.835 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.599255e-01 0.796 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.956466e-01 0.709 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.701657e-01 0.769 0 0
NGF-stimulated transcription R-HSA-9031628 2.701000e-01 0.568 0 0
Signaling by MET R-HSA-6806834 2.653812e-01 0.576 0 0
Polo-like kinase mediated events R-HSA-156711 2.268539e-01 0.644 0 0
Heme signaling R-HSA-9707616 1.956466e-01 0.709 0 0
Glycogen synthesis R-HSA-3322077 1.454467e-01 0.837 0 0
Neurodegenerative Diseases R-HSA-8863678 2.514923e-01 0.599 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.514923e-01 0.599 0 0
Ion transport by P-type ATPases R-HSA-936837 2.224316e-01 0.653 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.647514e-01 0.783 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.887073e-01 0.724 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.514923e-01 0.599 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.889049e-01 0.724 0 0
Cellular response to chemical stress R-HSA-9711123 1.739911e-01 0.759 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.088500e-01 0.680 0 0
Death Receptor Signaling R-HSA-73887 1.900920e-01 0.721 1 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.704544e-01 0.768 0 0
Regulation of insulin secretion R-HSA-422356 2.065760e-01 0.685 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.456905e-01 0.610 0 0
Inhibition of PKR R-HSA-169131 2.456905e-01 0.610 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.574723e-01 0.803 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.077485e-01 0.682 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.077485e-01 0.682 0 0
Reelin signalling pathway R-HSA-8866376 2.593741e-01 0.586 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.640302e-01 0.785 0 0
Signaling by AXIN mutants R-HSA-4839735 1.640302e-01 0.785 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.204684e-01 0.657 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.204684e-01 0.657 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.268539e-01 0.644 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.080250e-01 0.682 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.080250e-01 0.682 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.280438e-01 0.642 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.418080e-01 0.617 0 0
Signaling by NTRKs R-HSA-166520 1.943479e-01 0.711 0 0
Activation of BH3-only proteins R-HSA-114452 1.410717e-01 0.851 0 0
PI Metabolism R-HSA-1483255 2.512101e-01 0.600 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.587049e-01 0.587 0 0
Mitochondrial biogenesis R-HSA-1592230 2.332383e-01 0.632 0 0
Downstream signal transduction R-HSA-186763 2.698656e-01 0.569 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.473819e-01 0.832 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.900101e-01 0.721 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.688007e-01 0.773 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.593741e-01 0.586 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.077356e-01 0.682 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.260775e-01 0.646 0 0
Interleukin-1 family signaling R-HSA-446652 2.289651e-01 0.640 1 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.721597e-01 0.565 0 0
Signaling by Hedgehog R-HSA-5358351 2.764477e-01 0.558 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.593741e-01 0.586 0 0
RET signaling R-HSA-8853659 1.589152e-01 0.799 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.566287e-01 0.805 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.915903e-01 0.718 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.915903e-01 0.718 0 0
Assembly Of The HIV Virion R-HSA-175474 1.852007e-01 0.732 0 0
Signal regulatory protein family interactions R-HSA-391160 2.503953e-01 0.601 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.286483e-01 0.641 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 2.486846e-01 0.604 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.065145e-01 0.685 0 0
Maturation of nucleoprotein R-HSA-9694631 2.526197e-01 0.598 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.924265e-01 0.716 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.987392e-01 0.702 0 0
Regulation of BACH1 activity R-HSA-9708530 1.552347e-01 0.809 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.741311e-01 0.759 0 0
Depyrimidination R-HSA-73928 1.741311e-01 0.759 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.780011e-01 0.750 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.729572e-01 0.762 0 0
Translation of Structural Proteins R-HSA-9683701 1.599255e-01 0.796 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 2.593741e-01 0.586 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.780994e-01 0.556 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.780994e-01 0.556 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.780994e-01 0.556 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.780994e-01 0.556 0 0
Regulation of CDH11 function R-HSA-9762292 2.780994e-01 0.556 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.780994e-01 0.556 0 0
Selenoamino acid metabolism R-HSA-2408522 2.787055e-01 0.555 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.790597e-01 0.554 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.790597e-01 0.554 0 0
Erythropoietin activates RAS R-HSA-9027284 2.811060e-01 0.551 0 0
Protein methylation R-HSA-8876725 2.811060e-01 0.551 0 0
Degradation of AXIN R-HSA-4641257 2.841934e-01 0.546 0 0
Cleavage of the damaged purine R-HSA-110331 2.841934e-01 0.546 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.951948e-01 0.530 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.957355e-01 0.529 0 0
TBC/RABGAPs R-HSA-8854214 2.957355e-01 0.529 0 0
Signaling by FGFR4 R-HSA-5654743 2.957355e-01 0.529 0 0
NRAGE signals death through JNK R-HSA-193648 2.963824e-01 0.528 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.988598e-01 0.525 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.988598e-01 0.525 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.988598e-01 0.525 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.988598e-01 0.525 0 0
Depurination R-HSA-73927 3.043822e-01 0.517 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.052656e-01 0.515 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.060111e-01 0.514 0 0
G-protein activation R-HSA-202040 3.060111e-01 0.514 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.060111e-01 0.514 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.060111e-01 0.514 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.060111e-01 0.514 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.111257e-01 0.507 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.111257e-01 0.507 0 0
Proton/oligopeptide cotransporters R-HSA-427975 3.111257e-01 0.507 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.111257e-01 0.507 0 0
Platelet homeostasis R-HSA-418346 3.117294e-01 0.506 0 0
ER-Phagosome pathway R-HSA-1236974 3.120963e-01 0.506 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.123456e-01 0.505 0 0
Prolonged ERK activation events R-HSA-169893 3.123456e-01 0.505 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.123456e-01 0.505 0 0
Negative regulation of FLT3 R-HSA-9706369 3.123456e-01 0.505 0 0
G-protein beta:gamma signalling R-HSA-397795 3.135121e-01 0.504 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.135121e-01 0.504 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.135121e-01 0.504 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.135121e-01 0.504 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.135121e-01 0.504 0 0
RMTs methylate histone arginines R-HSA-3214858 3.147300e-01 0.502 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.161604e-01 0.500 0 0
Formation of the posterior neural plate R-HSA-9832991 3.161604e-01 0.500 0 0
Suppression of apoptosis R-HSA-9635465 3.161604e-01 0.500 0 0
Interleukin-2 signaling R-HSA-9020558 3.161604e-01 0.500 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.193815e-01 0.496 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.204824e-01 0.494 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.231568e-01 0.491 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.231568e-01 0.491 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.231568e-01 0.491 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.232542e-01 0.490 0 0
Downstream TCR signaling R-HSA-202424 3.259549e-01 0.487 1 1
Base Excision Repair R-HSA-73884 3.259549e-01 0.487 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.304145e-01 0.481 0 0
PCP/CE pathway R-HSA-4086400 3.312846e-01 0.480 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.333150e-01 0.477 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.333150e-01 0.477 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.333150e-01 0.477 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.336197e-01 0.477 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.336197e-01 0.477 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.336197e-01 0.477 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.339728e-01 0.476 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.339728e-01 0.476 0 0
Signaling by FGFR3 R-HSA-5654741 3.339728e-01 0.476 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.358090e-01 0.474 0 0
HCMV Infection R-HSA-9609646 3.369848e-01 0.472 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.418049e-01 0.466 0 0
Potential therapeutics for SARS R-HSA-9679191 3.430105e-01 0.465 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.448833e-01 0.462 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.448833e-01 0.462 0 0
Mitochondrial transcription initiation R-HSA-163282 3.448833e-01 0.462 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.448833e-01 0.462 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.448833e-01 0.462 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.448833e-01 0.462 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.448833e-01 0.462 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.448833e-01 0.462 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.448833e-01 0.462 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.448833e-01 0.462 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.448833e-01 0.462 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.448833e-01 0.462 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.448833e-01 0.462 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.448833e-01 0.462 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.448833e-01 0.462 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.448833e-01 0.462 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.448833e-01 0.462 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.448833e-01 0.462 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.448833e-01 0.462 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.448833e-01 0.462 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.448833e-01 0.462 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.448833e-01 0.462 0 0
Generation of second messenger molecules R-HSA-202433 3.455907e-01 0.461 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.455907e-01 0.461 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.464182e-01 0.460 0 0
Sensory processing of sound R-HSA-9659379 3.464182e-01 0.460 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.477140e-01 0.459 0 0
Circadian clock R-HSA-9909396 3.478260e-01 0.459 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.504851e-01 0.455 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.534105e-01 0.452 0 0
ERKs are inactivated R-HSA-202670 3.543003e-01 0.451 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.543003e-01 0.451 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.543003e-01 0.451 0 0
Integration of provirus R-HSA-162592 3.543003e-01 0.451 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.543003e-01 0.451 0 0
Platelet degranulation R-HSA-114608 3.574042e-01 0.447 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.583104e-01 0.446 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.583104e-01 0.446 1 1
Negative regulation of FGFR2 signaling R-HSA-5654727 3.583104e-01 0.446 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.583104e-01 0.446 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.608185e-01 0.443 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.608185e-01 0.443 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.608185e-01 0.443 0 0
Signaling by LTK in cancer R-HSA-9842640 3.620780e-01 0.441 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.620780e-01 0.441 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.620780e-01 0.441 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 3.620780e-01 0.441 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 3.620780e-01 0.441 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.620780e-01 0.441 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.620780e-01 0.441 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.620780e-01 0.441 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.620780e-01 0.441 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.662451e-01 0.436 0 0
Interferon gamma signaling R-HSA-877300 3.664461e-01 0.436 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.664793e-01 0.436 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.724235e-01 0.429 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.724235e-01 0.429 0 0
Signaling by ERBB4 R-HSA-1236394 3.736471e-01 0.428 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.754630e-01 0.425 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.754630e-01 0.425 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.754630e-01 0.425 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.754630e-01 0.425 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.754630e-01 0.425 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.754630e-01 0.425 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.770510e-01 0.424 0 0
Signaling by TGFB family members R-HSA-9006936 3.772893e-01 0.423 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.783109e-01 0.422 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.809350e-01 0.419 0 0
Aquaporin-mediated transport R-HSA-445717 3.827447e-01 0.417 0 0
Regulated Necrosis R-HSA-5218859 3.864973e-01 0.413 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.883766e-01 0.411 0 0
Neutrophil degranulation R-HSA-6798695 3.897846e-01 0.409 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.902059e-01 0.409 0 0
Repression of WNT target genes R-HSA-4641265 3.921562e-01 0.407 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.921562e-01 0.407 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.921562e-01 0.407 0 0
Regulation of IFNG signaling R-HSA-877312 3.921562e-01 0.407 0 0
Signaling by LTK R-HSA-9842663 3.921562e-01 0.407 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.921562e-01 0.407 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.936838e-01 0.405 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.971819e-01 0.401 0 0
Interleukin-37 signaling R-HSA-9008059 3.971819e-01 0.401 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.003801e-01 0.398 0 0
RUNX2 regulates bone development R-HSA-8941326 4.036043e-01 0.394 0 0
GAB1 signalosome R-HSA-180292 4.069117e-01 0.390 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.069117e-01 0.390 0 0
PKA activation R-HSA-163615 4.069117e-01 0.390 0 0
Apoptotic factor-mediated response R-HSA-111471 4.069117e-01 0.390 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.069117e-01 0.390 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.069117e-01 0.390 0 0
Activation of GABAB receptors R-HSA-991365 4.085050e-01 0.389 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.085050e-01 0.389 0 0
GABA B receptor activation R-HSA-977444 4.085050e-01 0.389 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.115467e-01 0.386 0 0
PTK6 Expression R-HSA-8849473 4.115467e-01 0.386 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.115467e-01 0.386 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.115467e-01 0.386 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.115467e-01 0.386 0 0
CHL1 interactions R-HSA-447041 4.115467e-01 0.386 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 4.115467e-01 0.386 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.115467e-01 0.386 0 0
Gap junction trafficking and regulation R-HSA-157858 4.123674e-01 0.385 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.123674e-01 0.385 0 0
TNF signaling R-HSA-75893 4.154856e-01 0.381 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.154856e-01 0.381 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.158536e-01 0.381 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.158536e-01 0.381 0 0
Complex III assembly R-HSA-9865881 4.158536e-01 0.381 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.158536e-01 0.381 0 0
Hemostasis R-HSA-109582 4.174071e-01 0.379 0 0
HCMV Late Events R-HSA-9610379 4.206564e-01 0.376 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.219979e-01 0.375 0 0
Transmission across Chemical Synapses R-HSA-112315 4.248819e-01 0.372 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.294176e-01 0.367 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.294176e-01 0.367 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.294176e-01 0.367 0 0
Frs2-mediated activation R-HSA-170968 4.294176e-01 0.367 0 0
Formation of axial mesoderm R-HSA-9796292 4.294176e-01 0.367 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.294176e-01 0.367 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.310371e-01 0.365 0 0
Signalling to ERK5 R-HSA-198765 4.310371e-01 0.365 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.310371e-01 0.365 0 0
Potassium transport channels R-HSA-1296067 4.310371e-01 0.365 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.310371e-01 0.365 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.310371e-01 0.365 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.310371e-01 0.365 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.310371e-01 0.365 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.310371e-01 0.365 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.310371e-01 0.365 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.310371e-01 0.365 0 0
C6 deamination of adenosine R-HSA-75102 4.310371e-01 0.365 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.310371e-01 0.365 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.324169e-01 0.364 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.380337e-01 0.358 0 0
Other interleukin signaling R-HSA-449836 4.380337e-01 0.358 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.431236e-01 0.353 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.431236e-01 0.353 0 0
G protein gated Potassium channels R-HSA-1296059 4.431236e-01 0.353 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.431236e-01 0.353 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.431236e-01 0.353 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.431236e-01 0.353 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.432101e-01 0.353 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.464576e-01 0.350 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.517032e-01 0.345 0 0
Interferon alpha/beta signaling R-HSA-909733 4.551165e-01 0.342 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.590410e-01 0.338 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.590410e-01 0.338 0 0
Adrenoceptors R-HSA-390696 4.590410e-01 0.338 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.590410e-01 0.338 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.590410e-01 0.338 0 0
cGMP effects R-HSA-418457 4.658245e-01 0.332 0 0
Removal of the Flap Intermediate R-HSA-69166 4.658245e-01 0.332 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.658245e-01 0.332 0 0
Prolactin receptor signaling R-HSA-1170546 4.658245e-01 0.332 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.658245e-01 0.332 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.679701e-01 0.330 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.686652e-01 0.329 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.700719e-01 0.328 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.700719e-01 0.328 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.700856e-01 0.328 0 0
Signaling by FGFR2 R-HSA-5654738 4.703923e-01 0.328 0 0
Nuclear RNA decay R-HSA-9930044 4.707962e-01 0.327 0 0
Regulation of beta-cell development R-HSA-186712 4.711117e-01 0.327 0 0
Signaling by ALK R-HSA-201556 4.711441e-01 0.327 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.712375e-01 0.327 0 0
Ion channel transport R-HSA-983712 4.746986e-01 0.324 0 0
Rab regulation of trafficking R-HSA-9007101 4.815315e-01 0.317 0 0
Cilium Assembly R-HSA-5617833 4.851527e-01 0.314 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.873664e-01 0.312 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.918875e-01 0.308 0 0
Signaling by TGFBR3 R-HSA-9839373 4.918875e-01 0.308 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.948274e-01 0.306 0 0
Developmental Biology R-HSA-1266738 4.948387e-01 0.306 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.965948e-01 0.304 0 0
Lagging Strand Synthesis R-HSA-69186 4.986632e-01 0.302 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.986632e-01 0.302 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 4.986632e-01 0.302 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.011640e-01 0.300 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.011640e-01 0.300 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.011640e-01 0.300 0 0
Biotin transport and metabolism R-HSA-196780 5.011640e-01 0.300 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.011640e-01 0.300 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.042248e-01 0.297 0 0
Lipophagy R-HSA-9613354 5.042248e-01 0.297 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 5.042248e-01 0.297 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.042248e-01 0.297 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.042248e-01 0.297 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.042248e-01 0.297 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.042248e-01 0.297 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.042248e-01 0.297 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.042248e-01 0.297 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.057101e-01 0.296 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.058653e-01 0.296 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.058653e-01 0.296 0 0
Axonal growth stimulation R-HSA-209563 5.058653e-01 0.296 0 0
MET activates PTPN11 R-HSA-8865999 5.058653e-01 0.296 0 0
Invadopodia formation R-HSA-8941237 5.058653e-01 0.296 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 5.058653e-01 0.296 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.058653e-01 0.296 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.058653e-01 0.296 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.058653e-01 0.296 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.058653e-01 0.296 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.058653e-01 0.296 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.058653e-01 0.296 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.058653e-01 0.296 0 0
MET interacts with TNS proteins R-HSA-8875513 5.058653e-01 0.296 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.076533e-01 0.294 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.118175e-01 0.291 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.122789e-01 0.290 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.226000e-01 0.282 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.244959e-01 0.280 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.352669e-01 0.271 0 0
Signalling to ERKs R-HSA-187687 5.416855e-01 0.266 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.432459e-01 0.265 0 0
DNA replication initiation R-HSA-68952 5.468845e-01 0.262 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.468845e-01 0.262 0 0
PI3K/AKT activation R-HSA-198203 5.468845e-01 0.262 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 5.468845e-01 0.262 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.468845e-01 0.262 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.468845e-01 0.262 0 0
2-LTR circle formation R-HSA-164843 5.468845e-01 0.262 0 0
Formation of apoptosome R-HSA-111458 5.468845e-01 0.262 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.468845e-01 0.262 0 0
Signaling by FGFR1 R-HSA-5654736 5.474996e-01 0.262 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.496552e-01 0.260 0 0
FGFR2 alternative splicing R-HSA-6803529 5.562885e-01 0.255 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.562885e-01 0.255 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.609661e-01 0.251 1 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.643894e-01 0.248 0 0
RNA Polymerase III Transcription R-HSA-74158 5.643894e-01 0.248 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.643894e-01 0.248 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.645939e-01 0.248 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.680032e-01 0.246 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.680032e-01 0.246 0 0
Synthesis of PG R-HSA-1483148 5.680032e-01 0.246 0 0
HCN channels R-HSA-1296061 5.708560e-01 0.243 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.708560e-01 0.243 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.708560e-01 0.243 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.708560e-01 0.243 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.708560e-01 0.243 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.708560e-01 0.243 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.708560e-01 0.243 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.708560e-01 0.243 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.708560e-01 0.243 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.708560e-01 0.243 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.708560e-01 0.243 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.708560e-01 0.243 0 0
GABA synthesis R-HSA-888568 5.708560e-01 0.243 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.708560e-01 0.243 0 0
NADE modulates death signalling R-HSA-205025 5.708560e-01 0.243 0 0
Dopamine receptors R-HSA-390651 5.708560e-01 0.243 0 0
DAP12 signaling R-HSA-2424491 5.727452e-01 0.242 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.727452e-01 0.242 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.727452e-01 0.242 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.865400e-01 0.232 0 0
LGI-ADAM interactions R-HSA-5682910 5.869024e-01 0.231 0 0
Synthesis of PI R-HSA-1483226 5.869024e-01 0.231 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.869024e-01 0.231 0 0
Trafficking of AMPA receptors R-HSA-399719 5.967564e-01 0.224 0 0
Proteasome assembly R-HSA-9907900 5.985638e-01 0.223 0 0
Gap junction trafficking R-HSA-190828 5.985638e-01 0.223 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.992779e-01 0.222 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.992779e-01 0.222 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.992779e-01 0.222 0 0
Signaling by FGFR in disease R-HSA-1226099 6.053916e-01 0.218 0 0
MET promotes cell motility R-HSA-8875878 6.080935e-01 0.216 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.080935e-01 0.216 0 0
Parasitic Infection Pathways R-HSA-9824443 6.088871e-01 0.215 0 0
Leishmania infection R-HSA-9658195 6.088871e-01 0.215 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.093088e-01 0.215 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.182409e-01 0.209 0 0
Somitogenesis R-HSA-9824272 6.182409e-01 0.209 0 0
Iron uptake and transport R-HSA-917937 6.210706e-01 0.207 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.210706e-01 0.207 0 0
Stimuli-sensing channels R-HSA-2672351 6.215626e-01 0.207 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.242355e-01 0.205 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.242355e-01 0.205 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.242355e-01 0.205 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.242355e-01 0.205 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.242355e-01 0.205 0 0
Sodium/Calcium exchangers R-HSA-425561 6.242355e-01 0.205 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.273021e-01 0.203 0 0
Defective F9 activation R-HSA-9673221 6.273021e-01 0.203 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.273021e-01 0.203 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.273021e-01 0.203 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.273021e-01 0.203 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.273021e-01 0.203 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.273021e-01 0.203 0 0
PTK6 Down-Regulation R-HSA-8849472 6.273021e-01 0.203 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.273021e-01 0.203 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.273021e-01 0.203 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.273021e-01 0.203 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.274904e-01 0.202 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.274904e-01 0.202 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.290128e-01 0.201 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.290269e-01 0.201 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.290269e-01 0.201 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.290269e-01 0.201 0 0
Platelet sensitization by LDL R-HSA-432142 6.290269e-01 0.201 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.296969e-01 0.201 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.355292e-01 0.197 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.373789e-01 0.196 0 0
Neurotransmitter release cycle R-HSA-112310 6.377739e-01 0.195 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.424119e-01 0.192 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.424119e-01 0.192 0 0
Translation of Structural Proteins R-HSA-9694635 6.514576e-01 0.186 0 0
Neuronal System R-HSA-112316 6.568997e-01 0.183 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.572126e-01 0.182 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.572126e-01 0.182 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.572126e-01 0.182 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.572126e-01 0.182 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.572126e-01 0.182 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.572126e-01 0.182 0 0
The NLRP3 inflammasome R-HSA-844456 6.572126e-01 0.182 0 0
Maple Syrup Urine Disease R-HSA-9865114 6.588977e-01 0.181 0 0
Interleukin-15 signaling R-HSA-8983432 6.588977e-01 0.181 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.588977e-01 0.181 0 0
OAS antiviral response R-HSA-8983711 6.588977e-01 0.181 0 0
Myogenesis R-HSA-525793 6.598026e-01 0.181 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.639871e-01 0.178 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.639871e-01 0.178 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.639871e-01 0.178 0 0
Hedgehog 'on' state R-HSA-5632684 6.746665e-01 0.171 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.763266e-01 0.170 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.763266e-01 0.170 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.763266e-01 0.170 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.763266e-01 0.170 0 0
Signaling by MST1 R-HSA-8852405 6.763266e-01 0.170 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.763266e-01 0.170 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.763266e-01 0.170 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.763266e-01 0.170 0 0
Phosphorylation of Emi1 R-HSA-176417 6.763266e-01 0.170 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.763266e-01 0.170 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.763266e-01 0.170 0 0
Relaxin receptors R-HSA-444821 6.763266e-01 0.170 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.763266e-01 0.170 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.763266e-01 0.170 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.763266e-01 0.170 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.763266e-01 0.170 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.763266e-01 0.170 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.763266e-01 0.170 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.829563e-01 0.166 0 0
Insulin processing R-HSA-264876 6.829563e-01 0.166 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.838201e-01 0.165 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.838201e-01 0.165 0 0
Signaling by NODAL R-HSA-1181150 6.838201e-01 0.165 0 0
Formation of definitive endoderm R-HSA-9823730 6.838201e-01 0.165 0 0
Protein hydroxylation R-HSA-9629569 6.838201e-01 0.165 0 0
Signal transduction by L1 R-HSA-445144 6.838201e-01 0.165 0 0
FOXO-mediated transcription R-HSA-9614085 6.842525e-01 0.165 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 6.909457e-01 0.161 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.909457e-01 0.161 0 0
ABC-family proteins mediated transport R-HSA-382556 6.966469e-01 0.157 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.040850e-01 0.152 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 7.088541e-01 0.149 0 0
Basigin interactions R-HSA-210991 7.088541e-01 0.149 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.188250e-01 0.143 0 0
Chylomicron clearance R-HSA-8964026 7.189049e-01 0.143 0 0
STAT5 Activation R-HSA-9645135 7.189049e-01 0.143 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.189049e-01 0.143 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 7.189049e-01 0.143 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.189049e-01 0.143 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.189049e-01 0.143 0 0
Agmatine biosynthesis R-HSA-351143 7.189049e-01 0.143 0 0
Neurofascin interactions R-HSA-447043 7.189049e-01 0.143 0 0
Abacavir transmembrane transport R-HSA-2161517 7.189049e-01 0.143 0 0
Lactose synthesis R-HSA-5653890 7.189049e-01 0.143 0 0
Leukotriene receptors R-HSA-391906 7.189049e-01 0.143 0 0
HDL clearance R-HSA-8964011 7.189049e-01 0.143 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.204673e-01 0.142 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.204673e-01 0.142 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.204673e-01 0.142 0 0
HDL assembly R-HSA-8963896 7.204673e-01 0.142 0 0
Zinc transporters R-HSA-435354 7.204673e-01 0.142 0 0
DARPP-32 events R-HSA-180024 7.258703e-01 0.139 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.323349e-01 0.135 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.323349e-01 0.135 0 0
MHC class II antigen presentation R-HSA-2132295 7.325435e-01 0.135 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.398187e-01 0.131 0 0
Netrin-1 signaling R-HSA-373752 7.399129e-01 0.131 0 0
GABA receptor activation R-HSA-977443 7.406887e-01 0.130 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.475725e-01 0.126 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 7.495230e-01 0.125 0 0
Leishmania parasite growth and survival R-HSA-9664433 7.495230e-01 0.125 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.497268e-01 0.125 0 0
RSV-host interactions R-HSA-9833110 7.541231e-01 0.123 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.542960e-01 0.122 0 0
Cellular hexose transport R-HSA-189200 7.542960e-01 0.122 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.542960e-01 0.122 0 0
LDL clearance R-HSA-8964038 7.542960e-01 0.122 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.542960e-01 0.122 0 0
SLC transporter disorders R-HSA-5619102 7.545169e-01 0.122 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.558843e-01 0.122 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.558843e-01 0.122 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.558843e-01 0.122 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.558843e-01 0.122 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.558843e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.558843e-01 0.122 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.558843e-01 0.122 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.558843e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.558843e-01 0.122 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.558843e-01 0.122 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.558843e-01 0.122 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.558843e-01 0.122 0 0
Opsins R-HSA-419771 7.558843e-01 0.122 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 7.558843e-01 0.122 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.558843e-01 0.122 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.558843e-01 0.122 0 0
VLDL clearance R-HSA-8964046 7.558843e-01 0.122 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.558843e-01 0.122 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.558843e-01 0.122 0 0
Netrin mediated repulsion signals R-HSA-418886 7.558843e-01 0.122 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.558843e-01 0.122 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.558843e-01 0.122 0 0
Maturation of replicase proteins R-HSA-9694301 7.558843e-01 0.122 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.586912e-01 0.120 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.624341e-01 0.118 0 0
Signaling by FGFR R-HSA-190236 7.624341e-01 0.118 0 0
Signaling by PDGF R-HSA-186797 7.682123e-01 0.115 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.714358e-01 0.113 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.714358e-01 0.113 0 0
Killing mechanisms R-HSA-9664420 7.723862e-01 0.112 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.723862e-01 0.112 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.723862e-01 0.112 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.723862e-01 0.112 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.723862e-01 0.112 0 0
Differentiation of T cells R-HSA-9945266 7.723862e-01 0.112 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.723862e-01 0.112 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.723862e-01 0.112 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.723862e-01 0.112 0 0
Virus Assembly and Release R-HSA-168268 7.723862e-01 0.112 0 0
RAS processing R-HSA-9648002 7.749901e-01 0.111 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.818712e-01 0.107 0 0
Immune System R-HSA-168256 7.840972e-01 0.106 1 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.880008e-01 0.103 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.880008e-01 0.103 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.880008e-01 0.103 0 0
MET receptor recycling R-HSA-8875656 7.880008e-01 0.103 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.880008e-01 0.103 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.880008e-01 0.103 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.880008e-01 0.103 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.880008e-01 0.103 0 0
Regulation by c-FLIP R-HSA-3371378 7.880008e-01 0.103 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.880008e-01 0.103 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.880008e-01 0.103 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.880008e-01 0.103 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.880008e-01 0.103 0 0
Dimerization of procaspase-8 R-HSA-69416 7.880008e-01 0.103 0 0
Interleukin-9 signaling R-HSA-8985947 7.880008e-01 0.103 0 0
Sodium/Proton exchangers R-HSA-425986 7.880008e-01 0.103 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.904309e-01 0.102 0 0
Interleukin-2 family signaling R-HSA-451927 7.904309e-01 0.102 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.938425e-01 0.100 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.950420e-01 0.100 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.950420e-01 0.100 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 7.950420e-01 0.100 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.040550e-01 0.095 0 0
Infectious disease R-HSA-5663205 8.083961e-01 0.092 1 0
Tight junction interactions R-HSA-420029 8.115380e-01 0.091 0 0
Glutamate and glutamine metabolism R-HSA-8964539 8.138775e-01 0.089 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.156781e-01 0.088 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.156781e-01 0.088 0 0
ARMS-mediated activation R-HSA-170984 8.158935e-01 0.088 0 0
WNT mediated activation of DVL R-HSA-201688 8.158935e-01 0.088 0 0
CASP8 activity is inhibited R-HSA-5218900 8.158935e-01 0.088 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.158935e-01 0.088 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.158935e-01 0.088 0 0
Interleukin-21 signaling R-HSA-9020958 8.158935e-01 0.088 0 0
mRNA Editing R-HSA-75072 8.158935e-01 0.088 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.158935e-01 0.088 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.158935e-01 0.088 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.158935e-01 0.088 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.158935e-01 0.088 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.158935e-01 0.088 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.158935e-01 0.088 0 0
Interleukin-1 processing R-HSA-448706 8.158935e-01 0.088 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.158935e-01 0.088 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.158935e-01 0.088 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.188130e-01 0.087 0 0
HIV Transcription Initiation R-HSA-167161 8.188130e-01 0.087 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.188130e-01 0.087 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.188130e-01 0.087 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.200696e-01 0.086 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.216052e-01 0.085 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.279301e-01 0.082 0 0
TRP channels R-HSA-3295583 8.279301e-01 0.082 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.283777e-01 0.082 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.283777e-01 0.082 0 0
Extension of Telomeres R-HSA-180786 8.313509e-01 0.080 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.344337e-01 0.079 0 0
Nephron development R-HSA-9831926 8.344337e-01 0.079 0 0
Leishmania phagocytosis R-HSA-9664417 8.390208e-01 0.076 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.390208e-01 0.076 0 0
Parasite infection R-HSA-9664407 8.390208e-01 0.076 0 0
Binding and entry of HIV virion R-HSA-173107 8.401178e-01 0.076 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.401178e-01 0.076 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.401178e-01 0.076 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.401178e-01 0.076 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.401178e-01 0.076 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.401178e-01 0.076 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.401178e-01 0.076 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.401178e-01 0.076 0 0
Interleukin-27 signaling R-HSA-9020956 8.401178e-01 0.076 0 0
Maturation of spike protein R-HSA-9683686 8.401178e-01 0.076 0 0
RAB geranylgeranylation R-HSA-8873719 8.420652e-01 0.075 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.420652e-01 0.075 0 0
tRNA processing R-HSA-72306 8.422989e-01 0.075 0 0
Adaptive Immune System R-HSA-1280218 8.426802e-01 0.074 1 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.430841e-01 0.074 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.438798e-01 0.074 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.440161e-01 0.074 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.514463e-01 0.070 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.514463e-01 0.070 0 0
Diseases of hemostasis R-HSA-9671793 8.514463e-01 0.070 0 0
Gastrulation R-HSA-9758941 8.530822e-01 0.069 0 0
ABC transporter disorders R-HSA-5619084 8.535739e-01 0.069 0 0
Glycosphingolipid transport R-HSA-9845576 8.545631e-01 0.068 0 0
GPVI-mediated activation cascade R-HSA-114604 8.545631e-01 0.068 0 0
DAP12 interactions R-HSA-2172127 8.554909e-01 0.068 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.570667e-01 0.067 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.570667e-01 0.067 0 0
Insulin receptor recycling R-HSA-77387 8.570667e-01 0.067 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.570667e-01 0.067 0 0
Inflammasomes R-HSA-622312 8.570667e-01 0.067 0 0
Pyroptosis R-HSA-5620971 8.570667e-01 0.067 0 0
COPII-mediated vesicle transport R-HSA-204005 8.571424e-01 0.067 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.611559e-01 0.065 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.611559e-01 0.065 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.611559e-01 0.065 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.611559e-01 0.065 0 0
vRNP Assembly R-HSA-192905 8.611559e-01 0.065 0 0
vRNA Synthesis R-HSA-192814 8.611559e-01 0.065 0 0
Chylomicron assembly R-HSA-8963888 8.611559e-01 0.065 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.611559e-01 0.065 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 8.611559e-01 0.065 0 0
Prostanoid ligand receptors R-HSA-391908 8.611559e-01 0.065 0 0
Transport of RCbl within the body R-HSA-9758890 8.611559e-01 0.065 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.611559e-01 0.065 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.611559e-01 0.065 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.644493e-01 0.063 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.660266e-01 0.062 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.662523e-01 0.062 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.668499e-01 0.062 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.668499e-01 0.062 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.668499e-01 0.062 0 0
Pyruvate metabolism R-HSA-70268 8.673295e-01 0.062 0 0
mRNA Capping R-HSA-72086 8.699455e-01 0.061 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.699455e-01 0.061 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.772702e-01 0.057 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.773730e-01 0.057 0 0
Cardiac conduction R-HSA-5576891 8.786298e-01 0.056 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 8.794268e-01 0.056 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.794268e-01 0.056 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.794268e-01 0.056 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.794268e-01 0.056 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.794268e-01 0.056 0 0
Plasmalogen biosynthesis R-HSA-75896 8.794268e-01 0.056 0 0
DS-GAG biosynthesis R-HSA-2022923 8.794268e-01 0.056 0 0
Insulin receptor signalling cascade R-HSA-74751 8.795679e-01 0.056 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.807731e-01 0.055 0 0
Signalling to RAS R-HSA-167044 8.807731e-01 0.055 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.807731e-01 0.055 0 0
Phenylalanine metabolism R-HSA-8964208 8.807731e-01 0.055 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.807731e-01 0.055 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.874253e-01 0.052 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.874253e-01 0.052 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.874253e-01 0.052 0 0
Cargo concentration in the ER R-HSA-5694530 8.926589e-01 0.049 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.926589e-01 0.049 0 0
Ribavirin ADME R-HSA-9755088 8.933388e-01 0.049 0 0
Metal ion SLC transporters R-HSA-425410 8.945557e-01 0.048 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.946620e-01 0.048 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.952943e-01 0.048 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.952943e-01 0.048 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.952943e-01 0.048 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.952943e-01 0.048 0 0
MET activates RAS signaling R-HSA-8851805 8.952943e-01 0.048 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.952943e-01 0.048 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.952943e-01 0.048 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.952943e-01 0.048 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.952943e-01 0.048 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.952943e-01 0.048 0 0
Interleukin-35 Signalling R-HSA-8984722 8.952943e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.952943e-01 0.048 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.968382e-01 0.047 0 0
Diseases of Immune System R-HSA-5260271 8.968382e-01 0.047 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.002855e-01 0.046 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.026241e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.046630e-01 0.044 0 0
Ethanol oxidation R-HSA-71384 9.046630e-01 0.044 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.055859e-01 0.043 0 0
Neddylation R-HSA-8951664 9.055993e-01 0.043 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.090744e-01 0.041 0 0
Chylomicron remodeling R-HSA-8963901 9.090744e-01 0.041 0 0
Processing of SMDT1 R-HSA-8949664 9.090744e-01 0.041 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.090744e-01 0.041 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.090744e-01 0.041 0 0
Peroxisomal protein import R-HSA-9033241 9.092318e-01 0.041 0 0
Transcription of the HIV genome R-HSA-167172 9.093414e-01 0.041 0 0
Intra-Golgi traffic R-HSA-6811438 9.136051e-01 0.039 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.137025e-01 0.039 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.148549e-01 0.039 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.148549e-01 0.039 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.148549e-01 0.039 0 0
Biosynthesis of maresins R-HSA-9018682 9.148549e-01 0.039 0 0
Carnitine shuttle R-HSA-200425 9.148549e-01 0.039 0 0
Syndecan interactions R-HSA-3000170 9.148549e-01 0.039 0 0
Metabolism of polyamines R-HSA-351202 9.159780e-01 0.038 0 0
Mitochondrial protein degradation R-HSA-9837999 9.190536e-01 0.037 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.200835e-01 0.036 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.210406e-01 0.036 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.210406e-01 0.036 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.210416e-01 0.036 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.210416e-01 0.036 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.210416e-01 0.036 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.210416e-01 0.036 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.210416e-01 0.036 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.210416e-01 0.036 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.210416e-01 0.036 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.210416e-01 0.036 0 0
Ciprofloxacin ADME R-HSA-9793528 9.210416e-01 0.036 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.210416e-01 0.036 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.210416e-01 0.036 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.240163e-01 0.034 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.240163e-01 0.034 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.240163e-01 0.034 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.240163e-01 0.034 0 0
G alpha (s) signalling events R-HSA-418555 9.270552e-01 0.033 0 0
Gap junction assembly R-HSA-190861 9.276952e-01 0.033 0 0
eNOS activation R-HSA-203615 9.276952e-01 0.033 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.276952e-01 0.033 0 0
Mitochondrial protein import R-HSA-1268020 9.281689e-01 0.032 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.302706e-01 0.031 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.313012e-01 0.031 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.314344e-01 0.031 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.314344e-01 0.031 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.314344e-01 0.031 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.314344e-01 0.031 0 0
p38MAPK events R-HSA-171007 9.314344e-01 0.031 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.314344e-01 0.031 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.314344e-01 0.031 0 0
Protein lipoylation R-HSA-9857492 9.314344e-01 0.031 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.314344e-01 0.031 0 0
Signaling by Activin R-HSA-1502540 9.314344e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.314344e-01 0.031 0 0
Hyaluronan degradation R-HSA-2160916 9.322418e-01 0.030 0 0
Potassium Channels R-HSA-1296071 9.334421e-01 0.030 0 0
Amine ligand-binding receptors R-HSA-375280 9.342106e-01 0.030 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.371543e-01 0.028 0 0
MET activates PTK2 signaling R-HSA-8874081 9.396190e-01 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.396190e-01 0.027 0 0
Abacavir ADME R-HSA-2161522 9.396190e-01 0.027 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.396190e-01 0.027 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.404597e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.404597e-01 0.027 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.404597e-01 0.027 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.404597e-01 0.027 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.404597e-01 0.027 0 0
Atorvastatin ADME R-HSA-9754706 9.404597e-01 0.027 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.404597e-01 0.027 0 0
Activation of SMO R-HSA-5635838 9.404597e-01 0.027 0 0
Fructose catabolism R-HSA-70350 9.404597e-01 0.027 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.404597e-01 0.027 0 0
Attachment and Entry R-HSA-9678110 9.404597e-01 0.027 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.453565e-01 0.024 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.453565e-01 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.453565e-01 0.024 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.461040e-01 0.024 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.462287e-01 0.024 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.462287e-01 0.024 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.462287e-01 0.024 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.462287e-01 0.024 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.462287e-01 0.024 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.464400e-01 0.024 0 0
Protein localization R-HSA-9609507 9.469114e-01 0.024 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.482975e-01 0.023 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.482975e-01 0.023 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.482975e-01 0.023 0 0
Heme assimilation R-HSA-9927020 9.482975e-01 0.023 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.482975e-01 0.023 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.482975e-01 0.023 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.482975e-01 0.023 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.482975e-01 0.023 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.482975e-01 0.023 0 0
Signaling by Insulin receptor R-HSA-74752 9.490951e-01 0.023 0 0
IRS-mediated signalling R-HSA-112399 9.506102e-01 0.022 0 0
Adipogenesis R-HSA-9843745 9.518680e-01 0.021 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.520705e-01 0.021 0 0
HIV elongation arrest and recovery R-HSA-167287 9.521451e-01 0.021 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.521451e-01 0.021 0 0
Telomere Extension By Telomerase R-HSA-171319 9.521451e-01 0.021 0 0
Intraflagellar transport R-HSA-5620924 9.547487e-01 0.020 0 0
Gluconeogenesis R-HSA-70263 9.547487e-01 0.020 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.551040e-01 0.020 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.551040e-01 0.020 0 0
Choline catabolism R-HSA-6798163 9.551040e-01 0.020 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.551040e-01 0.020 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.551040e-01 0.020 0 0
Developmental Cell Lineages R-HSA-9734767 9.566431e-01 0.019 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.566749e-01 0.019 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.574361e-01 0.019 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.574361e-01 0.019 0 0
G alpha (q) signalling events R-HSA-416476 9.585843e-01 0.018 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.586100e-01 0.018 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.586100e-01 0.018 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.594257e-01 0.018 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.609769e-01 0.017 0 0
HIV Transcription Elongation R-HSA-167169 9.609769e-01 0.017 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.609769e-01 0.017 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.610147e-01 0.017 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.610147e-01 0.017 0 0
Tie2 Signaling R-HSA-210993 9.610147e-01 0.017 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.610147e-01 0.017 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.621638e-01 0.017 0 0
Neurotransmitter clearance R-HSA-112311 9.621638e-01 0.017 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.621638e-01 0.017 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.626315e-01 0.017 0 0
PI3K Cascade R-HSA-109704 9.626315e-01 0.017 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.627045e-01 0.017 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.654065e-01 0.015 0 0
The phototransduction cascade R-HSA-2514856 9.660760e-01 0.015 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.661476e-01 0.015 0 0
Specification of the neural plate border R-HSA-9834899 9.661476e-01 0.015 0 0
Pyrimidine biosynthesis R-HSA-500753 9.661476e-01 0.015 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.661476e-01 0.015 0 0
Methionine salvage pathway R-HSA-1237112 9.661476e-01 0.015 0 0
HDL remodeling R-HSA-8964058 9.661476e-01 0.015 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.661476e-01 0.015 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.663674e-01 0.015 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.684035e-01 0.014 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.684035e-01 0.014 0 0
Heme biosynthesis R-HSA-189451 9.684035e-01 0.014 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.706049e-01 0.013 0 0
Pregnenolone biosynthesis R-HSA-196108 9.706049e-01 0.013 0 0
Melanin biosynthesis R-HSA-5662702 9.706049e-01 0.013 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.706049e-01 0.013 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.706049e-01 0.013 0 0
Creatine metabolism R-HSA-71288 9.706049e-01 0.013 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.711423e-01 0.013 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.717036e-01 0.012 0 0
Cardiogenesis R-HSA-9733709 9.735076e-01 0.012 0 0
IGF1R signaling cascade R-HSA-2428924 9.736920e-01 0.012 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.744755e-01 0.011 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.744755e-01 0.011 0 0
Abacavir metabolism R-HSA-2161541 9.744755e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.744755e-01 0.011 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.760156e-01 0.011 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.764984e-01 0.010 0 0
Heme degradation R-HSA-189483 9.764984e-01 0.010 0 0
Disease R-HSA-1643685 9.765236e-01 0.010 1 0
Paracetamol ADME R-HSA-9753281 9.771024e-01 0.010 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.778367e-01 0.010 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.778367e-01 0.010 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.778367e-01 0.010 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.778367e-01 0.010 0 0
Attachment and Entry R-HSA-9694614 9.778367e-01 0.010 0 0
RA biosynthesis pathway R-HSA-5365859 9.791612e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.791612e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.797288e-01 0.009 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.807554e-01 0.008 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.807554e-01 0.008 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.807554e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.807554e-01 0.008 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.807554e-01 0.008 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.807554e-01 0.008 0 0
Dectin-2 family R-HSA-5621480 9.812546e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.815304e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.815304e-01 0.008 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.815304e-01 0.008 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.832899e-01 0.007 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.832899e-01 0.007 0 0
Interleukin-20 family signaling R-HSA-8854691 9.832899e-01 0.007 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.834634e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.834634e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.836372e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.836372e-01 0.007 0 0
CYP2E1 reactions R-HSA-211999 9.854908e-01 0.006 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.854908e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.855096e-01 0.006 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.855096e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.855096e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.861715e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.861715e-01 0.006 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.874018e-01 0.006 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.874018e-01 0.006 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.874018e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.874018e-01 0.006 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.874018e-01 0.006 0 0
Formation of the nephric duct R-HSA-9830364 9.874018e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.874018e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.874018e-01 0.006 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.881212e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.886493e-01 0.005 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.890613e-01 0.005 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.890613e-01 0.005 0 0
Urea cycle R-HSA-70635 9.890613e-01 0.005 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.893715e-01 0.005 0 0
Innate Immune System R-HSA-168249 9.893865e-01 0.005 1 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.899595e-01 0.004 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.899595e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.903560e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.905023e-01 0.004 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.905023e-01 0.004 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.905023e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.905023e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.905023e-01 0.004 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.905023e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.906385e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.911216e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.911216e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.915026e-01 0.004 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.917535e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.917535e-01 0.004 0 0
Prednisone ADME R-HSA-9757110 9.917535e-01 0.004 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.921518e-01 0.003 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.938735e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.945896e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.945896e-01 0.002 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.946024e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.946024e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.946435e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.955694e-01 0.002 1 0
Metabolism of porphyrins R-HSA-189445 9.956320e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.956581e-01 0.002 1 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.959312e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.959312e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.961931e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.964674e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.965459e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.969329e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.969329e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.971631e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.972899e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.973372e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.973372e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.973372e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.975032e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.975032e-01 0.001 0 0
Triglyceride catabolism R-HSA-163560 9.976882e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.979214e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.979555e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.979869e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.979929e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.979929e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.979929e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.980613e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.980896e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.982575e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.982575e-01 0.001 0 0
Kidney development R-HSA-9830369 9.983008e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.983559e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.986866e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.986866e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.988598e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.989501e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990583e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.991638e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.993524e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.993708e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.993821e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.994378e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.994378e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.994378e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.994378e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.995402e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995722e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.995763e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.995865e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996322e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.996807e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.996807e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997096e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997228e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997449e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997520e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.997938e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998089e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998272e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998272e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998272e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998479e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998482e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998634e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998651e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998830e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998973e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.999224e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999307e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999416e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999416e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999487e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999532e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999532e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999618e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999623e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999627e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999648e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999726e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999739e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999750e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999750e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999750e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999783e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999788e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999853e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999858e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999858e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999907e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999919e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999919e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999920e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999939e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.999947e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999948e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999953e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999954e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999954e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999954e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999958e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999963e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999963e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999974e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999975e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999986e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999987e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999989e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999991e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999997e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways