ACVR2A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00592 T556 Sugiyama PODXL PCLP PCLP1 DsWIVPLDNLTKDDLDEEEDtHL__________________
O43615 S193 Sugiyama TIMM44 MIMT44 TIM44 TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95394 S64 Sugiyama PGM3 AGM1 LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S114 Sugiyama ALPP PLAP DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787 S477 Sugiyama KRT8 CYK8 SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y472 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08670 S299 Sugiyama VIM VAAKNLQEAEEWyKSKFADLsEAANRNNDALRQAKQESTEY
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10696 S111 Sugiyama ALPG ALPPL ALPPL2 DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 T103 Sugiyama PRKCSH G19P1 KPLyIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKE
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P18858 T183 Sugiyama LIG1 sLTEAEVAtEKEGEDGDQPttPPKPLKTSKAEtPtEsVsEP
P18887 T457 Sugiyama XRCC1 tKPtQAAGPssPQKPPtPEEtKAAsPVLQEDIDIEGVQsEG
P21333 S1459 Sugiyama FLNA FLN FLN1 KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816 S1151 Sugiyama MAP4 LSGGGDQREAQtLDsQIQEtsI___________________
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 S414 Sugiyama HSPA4 APG2 HSPH2 ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35269 S217 Sugiyama GTF2F1 RAP74 RGRRKASELRIHDLEDDLEMssDAsDAsGEEGGRVPKAKKK
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P36871 S477 Sugiyama PGM1 KQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDG
P43121 T299 Sugiyama MCAM MUC18 PPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRYE
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49589 S305 Sugiyama CARS1 CARS KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49589 S312 Sugiyama CARS1 CARS GDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASKPGEPS
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50613 S164 Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 LLDENGVLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELL
P50613 T170 Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 VLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELLFGARMY
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P55081 T267 Sugiyama MFAP1 ETKKELEENKRsLAALDALNtDDENDEEEyEAWKVRELKRI
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P63104 S145 Sugiyama YWHAZ YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q08J23 T733 Sugiyama NSUN2 SAKI TRM4 EGVILtNEsAAstGQPDNDVtEGQRAGEPNsPDAEEANsPD
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13098 S468 Sugiyama GPS1 COPS1 CSN1 RRAKAMMLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMs
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14155 S518 Sugiyama ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15052 S488 Sugiyama ARHGEF6 COOL2 KIAA0006 PIXA ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15637 S80 Sugiyama SF1 ZFM1 ZNF162 DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16513 T958 Sugiyama PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92688 S104 Sugiyama ANP32B APRIL PHAPI2 AEKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCE
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H0J4 S1620 Sugiyama QRICH2 GHIYKGRMDTRLPGILRKDSsGTSKRKSQQPRPHVHRPPSL
Q9H6Z4 T363 Sugiyama RANBP3 DANRENAAAEsGsEsssQEAtPEKESLAEsAAAyTKATARK
Q9H7D7 S123 Sugiyama WDR26 CDW2 MIP2 PRO0852 SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H8H2 S78 Sugiyama DDX31 LGTSPYSWSRSGPGRGGGAGsSRVPRGVPGPAVCAPGSLLH
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9UI30 S125 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 RMFPISRGIPNMLLsEEEtEs____________________
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.192535e-08 7.659 0 0
Metabolism of RNA R-HSA-8953854 1.505376e-07 6.822 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.156819e-05 4.937 0 0
mRNA Splicing R-HSA-72172 1.118596e-05 4.951 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.238759e-05 4.205 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.742635e-05 4.011 0 0
Chromatin organization R-HSA-4839726 1.252923e-04 3.902 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.097098e-04 3.678 0 0
Chromatin modifying enzymes R-HSA-3247509 2.372588e-04 3.625 0 0
Apoptotic execution phase R-HSA-75153 2.511553e-04 3.600 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.984567e-04 3.400 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.837580e-04 3.234 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.456945e-04 3.263 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.280402e-04 3.202 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.340941e-04 3.198 0 0
Cell Cycle R-HSA-1640170 8.790794e-04 3.056 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.078917e-03 2.967 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.355454e-03 2.868 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.623009e-03 2.790 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.417521e-03 2.617 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.501683e-03 2.602 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.501683e-03 2.602 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.784014e-03 2.555 0 0
Cell Cycle, Mitotic R-HSA-69278 2.857125e-03 2.544 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.912534e-03 2.536 0 0
Separation of Sister Chromatids R-HSA-2467813 3.156053e-03 2.501 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.392835e-03 2.469 0 0
M Phase R-HSA-68886 3.521945e-03 2.453 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.927842e-03 2.406 0 0
Mitotic Prometaphase R-HSA-68877 3.958837e-03 2.402 0 0
Cellular response to heat stress R-HSA-3371556 3.881117e-03 2.411 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.301872e-03 2.366 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.378590e-03 2.359 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.963180e-03 2.304 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 5.573907e-03 2.254 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.898330e-03 2.229 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.130296e-03 2.213 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.334172e-03 2.198 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.334172e-03 2.198 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.676549e-03 2.246 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.074834e-03 2.216 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.846418e-03 2.233 0 0
mRNA 3'-end processing R-HSA-72187 6.627338e-03 2.179 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.008682e-03 2.154 0 0
MTOR signalling R-HSA-165159 7.078778e-03 2.150 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.886734e-03 2.103 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.886734e-03 2.103 0 0
DNA Repair R-HSA-73894 7.528233e-03 2.123 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.972781e-03 2.047 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.564810e-03 2.019 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.050171e-02 1.979 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.227362e-02 1.911 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.319963e-02 1.879 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.309971e-02 1.883 0 0
Signaling by LTK R-HSA-9842663 1.227362e-02 1.911 0 0
Mitotic Anaphase R-HSA-68882 1.267987e-02 1.897 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.324188e-02 1.878 0 0
Signaling by ERBB2 R-HSA-1227986 1.403880e-02 1.853 0 0
Nucleotide Excision Repair R-HSA-5696398 1.411887e-02 1.850 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.499489e-02 1.824 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.521001e-02 1.818 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.545050e-02 1.811 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.621096e-02 1.790 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.527780e-02 1.816 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.598255e-02 1.796 0 0
Signaling by ALK in cancer R-HSA-9700206 1.598255e-02 1.796 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.678989e-02 1.775 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.746177e-02 1.758 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.794817e-02 1.746 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.794817e-02 1.746 0 0
Post NMDA receptor activation events R-HSA-438064 1.868427e-02 1.729 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.872473e-02 1.728 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.074952e-02 1.683 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.074952e-02 1.683 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.074952e-02 1.683 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.074952e-02 1.683 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.074952e-02 1.683 0 0
Cell Cycle Checkpoints R-HSA-69620 2.166226e-02 1.664 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.184058e-02 1.661 0 0
Type I hemidesmosome assembly R-HSA-446107 2.331517e-02 1.632 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.431489e-02 1.614 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.431489e-02 1.614 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.425972e-02 1.615 0 0
IRE1alpha activates chaperones R-HSA-381070 2.576627e-02 1.589 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.601097e-02 1.585 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.667974e-02 1.574 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.861796e-02 1.543 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.909394e-02 1.536 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.555822e-02 1.449 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.555822e-02 1.449 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.409647e-02 1.467 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.409647e-02 1.467 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.606139e-02 1.443 0 0
Metabolism of non-coding RNA R-HSA-194441 3.353684e-02 1.474 0 0
snRNP Assembly R-HSA-191859 3.353684e-02 1.474 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.284335e-02 1.484 0 0
HIV Life Cycle R-HSA-162587 3.496788e-02 1.456 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.128471e-02 1.505 0 0
Signaling by Hippo R-HSA-2028269 3.409647e-02 1.467 0 0
Deubiquitination R-HSA-5688426 3.279163e-02 1.484 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.606586e-02 1.443 0 0
Amino acid transport across the plasma membrane R-HSA-352230 3.353684e-02 1.474 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.027292e-02 1.519 0 0
Ephrin signaling R-HSA-3928664 3.906845e-02 1.408 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.906845e-02 1.408 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.906845e-02 1.408 0 0
Regulation of TP53 Activity R-HSA-5633007 3.969237e-02 1.401 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.090445e-02 1.388 0 0
rRNA processing R-HSA-72312 4.122616e-02 1.385 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.347830e-02 1.362 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.347830e-02 1.362 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.347830e-02 1.362 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.529039e-02 1.344 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.691534e-02 1.329 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.309691e-02 1.366 0 0
Signaling by ALK R-HSA-201556 4.309691e-02 1.366 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.269714e-02 1.370 0 0
Signal Transduction R-HSA-162582 4.837983e-02 1.315 1 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.712399e-02 1.243 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.712399e-02 1.243 0 0
Disorders of Nervous System Development R-HSA-9697154 5.893138e-02 1.230 0 0
Pervasive developmental disorders R-HSA-9005895 5.893138e-02 1.230 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.893138e-02 1.230 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.893138e-02 1.230 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.893138e-02 1.230 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.893138e-02 1.230 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.018708e-02 1.299 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.633094e-02 1.249 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.633094e-02 1.249 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.285980e-02 1.202 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.285980e-02 1.202 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.994616e-02 1.301 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.994616e-02 1.301 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.487269e-02 1.261 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.487269e-02 1.261 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.973607e-02 1.303 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.338672e-02 1.273 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.204534e-02 1.284 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.821862e-02 1.235 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.821862e-02 1.235 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.712399e-02 1.243 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.712399e-02 1.243 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.959442e-02 1.225 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.994616e-02 1.301 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.093687e-02 1.293 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.712399e-02 1.243 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.285980e-02 1.202 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.633094e-02 1.249 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.285980e-02 1.202 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.562992e-02 1.255 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.031478e-02 1.298 0 0
SLC-mediated transport of amino acids R-HSA-9958863 5.738683e-02 1.241 0 0
Basigin interactions R-HSA-210991 5.633094e-02 1.249 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.516291e-02 1.258 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.575096e-02 1.254 0 0
Signaling by EGFR R-HSA-177929 6.532344e-02 1.185 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.553761e-02 1.184 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.037641e-01 0.984 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.037641e-01 0.984 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.037641e-01 0.984 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.037641e-01 0.984 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.037641e-01 0.984 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.037641e-01 0.984 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 1.515402e-01 0.819 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.515402e-01 0.819 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.515402e-01 0.819 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 1.515402e-01 0.819 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 1.515402e-01 0.819 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.203271e-02 1.142 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.203271e-02 1.142 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.967721e-01 0.706 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 1.967721e-01 0.706 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.049617e-01 0.979 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.049617e-01 0.979 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 1.049617e-01 0.979 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.049617e-01 0.979 0 0
Regulation of PTEN localization R-HSA-8948747 1.049617e-01 0.979 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.395953e-01 0.621 0 0
PLC-gamma1 signalling R-HSA-167021 2.395953e-01 0.621 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.395953e-01 0.621 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.395953e-01 0.621 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 2.395953e-01 0.621 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 2.395953e-01 0.621 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.395953e-01 0.621 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.410522e-01 0.851 0 0
Calcineurin activates NFAT R-HSA-2025928 1.410522e-01 0.851 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.801379e-01 0.553 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.801379e-01 0.553 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.801379e-01 0.553 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.801379e-01 0.553 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.801379e-01 0.553 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.801379e-01 0.553 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.782498e-02 1.056 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.782498e-02 1.056 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.782498e-02 1.056 0 0
2-LTR circle formation R-HSA-164843 1.599606e-01 0.796 0 0
Notch-HLH transcription pathway R-HSA-350054 6.976817e-02 1.156 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.097849e-01 0.959 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.792953e-01 0.746 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.185212e-01 0.497 0 0
IRS activation R-HSA-74713 3.185212e-01 0.497 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.185212e-01 0.497 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.185212e-01 0.497 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.989572e-01 0.701 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.989572e-01 0.701 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.010394e-01 0.996 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.461296e-01 0.835 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.188568e-01 0.660 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.548601e-01 0.450 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.548601e-01 0.450 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 3.548601e-01 0.450 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 3.548601e-01 0.450 0 0
Signaling by MAPK mutants R-HSA-9652817 3.548601e-01 0.450 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.097171e-01 0.960 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.097171e-01 0.960 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.097171e-01 0.960 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.354263e-02 1.078 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.187153e-01 0.925 0 0
HIV elongation arrest and recovery R-HSA-167287 1.187153e-01 0.925 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.187153e-01 0.925 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.187153e-01 0.925 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.412448e-02 1.130 0 0
Activation of the pre-replicative complex R-HSA-68962 1.376205e-01 0.861 0 0
STAT5 Activation R-HSA-9645135 3.892634e-01 0.410 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.892634e-01 0.410 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.892634e-01 0.410 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.892634e-01 0.410 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.892634e-01 0.410 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 3.892634e-01 0.410 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 3.892634e-01 0.410 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.892634e-01 0.410 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.892634e-01 0.410 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 3.892634e-01 0.410 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.995373e-01 0.700 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.186768e-01 0.926 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.792096e-01 0.554 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.792096e-01 0.554 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.135523e-01 0.670 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.135523e-01 0.670 0 0
Deadenylation of mRNA R-HSA-429947 2.277691e-01 0.643 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.993253e-01 0.524 0 0
SOS-mediated signalling R-HSA-112412 4.218339e-01 0.375 0 0
Recycling of eIF2:GDP R-HSA-72731 4.218339e-01 0.375 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 4.218339e-01 0.375 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 4.218339e-01 0.375 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.217341e-01 0.915 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.989701e-02 1.046 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.100320e-01 0.958 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.193469e-01 0.496 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.427108e-01 0.846 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.117915e-01 0.674 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.773911e-01 0.751 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.773911e-01 0.751 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.023008e-02 1.153 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.713322e-01 0.566 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.713322e-01 0.566 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.392271e-01 0.470 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.526694e-01 0.344 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.526694e-01 0.344 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.589243e-01 0.445 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.346819e-01 0.630 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.784015e-01 0.422 0 0
Regulation of signaling by CBL R-HSA-912631 3.784015e-01 0.422 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.818621e-01 0.317 0 0
WNT mediated activation of DVL R-HSA-201688 4.818621e-01 0.317 0 0
ALK mutants bind TKIs R-HSA-9700645 4.818621e-01 0.317 0 0
EGFR downregulation R-HSA-182971 3.305254e-01 0.481 0 0
Translation initiation complex formation R-HSA-72649 2.548379e-01 0.594 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.871308e-01 0.728 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.165699e-01 0.380 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.165699e-01 0.380 0 0
Dual incision in TC-NER R-HSA-6782135 2.962763e-01 0.528 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.962763e-01 0.528 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.352081e-01 0.361 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.514463e-01 0.600 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.555692e-01 0.449 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.845332e-01 0.546 0 0
FGFR2 alternative splicing R-HSA-6803529 4.535194e-01 0.343 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.535194e-01 0.343 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.494093e-01 0.457 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.494093e-01 0.457 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.187680e-01 0.497 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.714857e-01 0.327 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.714857e-01 0.327 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.815707e-01 0.418 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.624459e-01 0.441 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.288696e-01 0.368 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.701724e-01 0.432 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.701724e-01 0.432 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.560252e-01 0.341 0 0
Centrosome maturation R-HSA-380287 4.768917e-01 0.322 0 0
Transcription of the HIV genome R-HSA-167172 4.029901e-01 0.395 0 0
Signaling by NOTCH2 R-HSA-1980145 3.895884e-01 0.409 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.010394e-01 0.996 0 0
HIV Transcription Elongation R-HSA-167169 1.186768e-01 0.926 0 0
EPH-Ephrin signaling R-HSA-2682334 1.124768e-01 0.949 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 4.165699e-01 0.380 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.376205e-01 0.861 0 0
mRNA Capping R-HSA-72086 3.008558e-01 0.522 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.404660e-01 0.619 0 0
Ribosome-associated quality control R-HSA-9948299 1.494285e-01 0.826 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.722380e-01 0.764 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.579721e-01 0.339 0 0
RNA Polymerase III Transcription R-HSA-74158 2.117915e-01 0.674 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.186768e-01 0.926 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.174067e-01 0.498 0 0
Signal attenuation R-HSA-74749 1.599606e-01 0.796 0 0
Integration of provirus R-HSA-162592 1.989572e-01 0.701 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.336053e-01 0.874 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.376205e-01 0.861 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.253662e-02 1.139 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.773911e-01 0.751 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.773911e-01 0.751 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.773911e-01 0.751 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.309976e-01 0.480 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.187403e-01 0.497 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.292288e-01 0.640 0 0
Disorders of Developmental Biology R-HSA-9675151 1.097849e-01 0.959 0 0
Integrin signaling R-HSA-354192 3.601577e-01 0.444 0 0
IGF1R signaling cascade R-HSA-2428924 2.057547e-01 0.687 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.762393e-02 1.110 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.782498e-02 1.056 0 0
Regulation of CDH11 function R-HSA-9762292 1.599606e-01 0.796 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.111601e-01 0.954 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.392271e-01 0.470 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.582836e-01 0.588 0 0
Eukaryotic Translation Termination R-HSA-72764 3.624459e-01 0.441 0 0
Attenuation phase R-HSA-3371568 4.753123e-01 0.323 0 0
Peptide chain elongation R-HSA-156902 4.389379e-01 0.358 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.445336e-01 0.463 0 0
Myogenesis R-HSA-525793 1.010394e-01 0.996 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.685028e-02 1.014 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.309976e-01 0.480 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.376205e-01 0.861 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.352081e-01 0.361 0 0
PTEN Regulation R-HSA-6807070 3.525217e-01 0.453 0 0
Generation of second messenger molecules R-HSA-202433 4.753123e-01 0.323 0 0
CREB phosphorylation R-HSA-199920 8.803137e-02 1.055 0 0
Regulation of gap junction activity R-HSA-191650 2.801379e-01 0.553 0 0
NF-kB is activated and signals survival R-HSA-209560 1.989572e-01 0.701 0 0
Signaling by MST1 R-HSA-8852405 3.548601e-01 0.450 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.857552e-01 0.731 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.193469e-01 0.496 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.589243e-01 0.445 0 0
HSF1-dependent transactivation R-HSA-3371571 2.247785e-01 0.648 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.818621e-01 0.317 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.753123e-01 0.323 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.470874e-02 1.127 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.381132e-02 1.132 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.142611e-01 0.669 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.784015e-01 0.422 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.512702e-01 0.600 0 0
Long-term potentiation R-HSA-9620244 9.269473e-02 1.033 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.188568e-01 0.660 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.344014e-01 0.872 0 0
RNA Polymerase I Transcription R-HSA-73864 3.332391e-01 0.477 0 0
DAP12 signaling R-HSA-2424491 1.376205e-01 0.861 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.673484e-01 0.776 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.736487e-01 0.760 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 1.410522e-01 0.851 0 0
Formation of the posterior neural plate R-HSA-9832991 1.792953e-01 0.746 0 0
Synthesis of PI R-HSA-1483226 1.792953e-01 0.746 0 0
Activation of AKT2 R-HSA-165158 3.185212e-01 0.497 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.188568e-01 0.660 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.792096e-01 0.554 0 0
PTK6 Expression R-HSA-8849473 4.218339e-01 0.375 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.094030e-02 1.092 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.193469e-01 0.496 0 0
Signaling by RAS mutants R-HSA-6802949 1.773911e-01 0.751 0 0
Negative regulation of MET activity R-HSA-6807004 3.976262e-01 0.401 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.976262e-01 0.401 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.165699e-01 0.380 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.164886e-01 0.665 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.274413e-01 0.485 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.330443e-01 0.363 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.652207e-01 0.782 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.404660e-01 0.619 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.188568e-01 0.660 0 0
mTORC1-mediated signalling R-HSA-166208 1.995373e-01 0.700 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.895742e-02 1.005 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.566878e-01 0.591 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.254181e-01 0.371 0 0
Lipophagy R-HSA-9613354 1.410522e-01 0.851 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.548601e-01 0.450 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.892634e-01 0.410 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.892634e-01 0.410 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.995373e-01 0.700 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.566878e-01 0.591 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.536134e-01 0.814 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.818621e-01 0.317 0 0
Signalling to RAS R-HSA-167044 4.165699e-01 0.380 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.068150e-01 0.513 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.142119e-01 0.503 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.535194e-01 0.343 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.753123e-01 0.323 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.560252e-01 0.341 0 0
Signaling by NOTCH3 R-HSA-9012852 2.650710e-01 0.577 0 0
RAF activation R-HSA-5673000 3.895884e-01 0.409 0 0
MET promotes cell motility R-HSA-8875878 4.472834e-01 0.349 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.293727e-01 0.367 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.536134e-01 0.814 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.803137e-02 1.055 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.231974e-01 0.651 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.976262e-01 0.401 0 0
DNA Double Strand Break Response R-HSA-5693606 1.217353e-01 0.915 0 0
Regulation of CDH1 Function R-HSA-9764561 4.765436e-01 0.322 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.410522e-01 0.851 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.713322e-01 0.566 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.380101e-01 0.860 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.714857e-01 0.327 0 0
p75NTR signals via NF-kB R-HSA-193639 2.792096e-01 0.554 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.995373e-01 0.700 0 0
HDMs demethylate histones R-HSA-3214842 2.421574e-01 0.616 0 0
Signaling by FGFR2 R-HSA-5654738 2.115392e-01 0.675 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.515402e-01 0.819 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.967721e-01 0.706 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.801379e-01 0.553 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.801379e-01 0.553 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.599606e-01 0.796 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.989572e-01 0.701 0 0
ERKs are inactivated R-HSA-202670 1.989572e-01 0.701 0 0
PDE3B signalling R-HSA-165160 3.548601e-01 0.450 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.548601e-01 0.450 0 0
Synthesis of PS R-HSA-1483101 3.548601e-01 0.450 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.548601e-01 0.450 0 0
PKB-mediated events R-HSA-109703 3.548601e-01 0.450 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.548601e-01 0.450 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.389129e-01 0.622 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.280210e-01 0.893 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.857552e-01 0.731 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.852624e-02 1.053 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.277691e-01 0.643 0 0
Mitochondrial ABC transporters R-HSA-1369007 4.218339e-01 0.375 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.509988e-01 0.821 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.895084e-01 0.722 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.392271e-01 0.470 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.784015e-01 0.422 0 0
Unwinding of DNA R-HSA-176974 4.818621e-01 0.317 0 0
Cargo concentration in the ER R-HSA-5694530 3.305254e-01 0.481 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.749077e-01 0.426 0 0
MAP kinase activation R-HSA-450294 3.280422e-01 0.484 0 0
Orc1 removal from chromatin R-HSA-68949 4.167613e-01 0.380 0 0
Signaling by NOTCH4 R-HSA-9013694 4.664895e-01 0.331 0 0
HIV Infection R-HSA-162906 2.032194e-01 0.692 0 0
Signaling by FGFR4 R-HSA-5654743 1.509988e-01 0.821 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.289017e-01 0.483 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.601577e-01 0.444 0 0
Mismatch Repair R-HSA-5358508 3.589243e-01 0.445 0 0
Aggrephagy R-HSA-9646399 1.186768e-01 0.926 0 0
HATs acetylate histones R-HSA-3214847 8.494257e-02 1.071 0 0
Signaling by FGFR3 R-HSA-5654741 1.684056e-01 0.774 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.773911e-01 0.751 0 0
Biotin transport and metabolism R-HSA-196780 8.782498e-02 1.056 0 0
Membrane Trafficking R-HSA-199991 2.037028e-01 0.691 0 0
Interleukin-17 signaling R-HSA-448424 4.243205e-01 0.372 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.792096e-01 0.554 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.680359e-01 0.775 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.438060e-01 0.353 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.187479e-01 0.925 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.438060e-01 0.353 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.681650e-01 0.330 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.005566e-01 0.698 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.469500e-01 0.833 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.410522e-01 0.851 0 0
ERK/MAPK targets R-HSA-198753 1.722380e-01 0.764 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.590524e-01 0.587 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.526694e-01 0.344 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.822437e-01 0.549 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.920259e-02 1.003 0 0
TBC/RABGAPs R-HSA-8854214 3.065197e-01 0.514 0 0
MAPK family signaling cascades R-HSA-5683057 2.170651e-01 0.663 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.681650e-01 0.330 0 0
Signaling by VEGF R-HSA-194138 8.854934e-02 1.053 0 0
Signaling by FGFR1 R-HSA-5654736 2.753949e-01 0.560 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.909121e-01 0.408 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.664895e-01 0.331 0 0
FLT3 signaling in disease R-HSA-9682385 2.117915e-01 0.674 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.185212e-01 0.497 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.127382e-02 1.147 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.937839e-02 1.100 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.218339e-01 0.375 0 0
HDACs deacetylate histones R-HSA-3214815 2.650710e-01 0.577 0 0
TNF signaling R-HSA-75893 2.753949e-01 0.560 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.702169e-01 0.568 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.943495e-01 0.531 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.538745e-01 0.451 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.538745e-01 0.451 0 0
Axon guidance R-HSA-422475 8.851811e-02 1.053 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.135789e-01 0.504 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.067975e-01 0.684 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.280210e-01 0.893 0 0
RET signaling R-HSA-8853659 4.186724e-01 0.378 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.844106e-01 0.734 0 0
Signaling by MET R-HSA-6806834 3.523981e-01 0.453 0 0
Nervous system development R-HSA-9675108 7.037641e-02 1.153 0 0
Gastrulation R-HSA-9758941 3.110395e-01 0.507 0 0
Cell junction organization R-HSA-446728 1.015978e-01 0.993 0 0
DAP12 interactions R-HSA-2172127 3.187403e-01 0.497 0 0
Signaling by FGFR R-HSA-190236 3.888926e-01 0.410 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.536577e-01 0.451 0 0
Kinesins R-HSA-983189 8.355546e-02 1.078 0 0
Adherens junctions interactions R-HSA-418990 2.382656e-01 0.623 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.518166e-01 0.599 0 0
Interleukin-15 signaling R-HSA-8983432 2.188568e-01 0.660 0 0
Ion transport by P-type ATPases R-HSA-936837 2.057547e-01 0.687 0 0
Autophagy R-HSA-9612973 3.581111e-01 0.446 0 0
Ub-specific processing proteases R-HSA-5689880 1.118198e-01 0.951 0 0
Cell-cell junction organization R-HSA-421270 3.199748e-01 0.495 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.747629e-01 0.758 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.747629e-01 0.758 0 0
Rab regulation of trafficking R-HSA-9007101 4.274761e-01 0.369 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.395953e-01 0.621 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.892634e-01 0.410 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.135523e-01 0.670 0 0
VLDL clearance R-HSA-8964046 4.218339e-01 0.375 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.218339e-01 0.375 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.526694e-01 0.344 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.526694e-01 0.344 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.526694e-01 0.344 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.526694e-01 0.344 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.589243e-01 0.445 0 0
Specification of the neural plate border R-HSA-9834899 3.784015e-01 0.422 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.818621e-01 0.317 0 0
G2/M Checkpoints R-HSA-69481 2.555495e-01 0.593 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.523981e-01 0.453 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.588271e-01 0.799 0 0
Death Receptor Signaling R-HSA-73887 9.590016e-02 1.018 0 0
S Phase R-HSA-69242 2.050482e-01 0.688 0 0
Homology Directed Repair R-HSA-5693538 3.009175e-01 0.522 0 0
Gene expression (Transcription) R-HSA-74160 2.506370e-01 0.601 0 0
Cell-Cell communication R-HSA-1500931 1.661778e-01 0.779 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.523981e-01 0.453 0 0
Cellular responses to stress R-HSA-2262752 1.492865e-01 0.826 0 0
Heme signaling R-HSA-9707616 1.891231e-01 0.723 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.546451e-01 0.811 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.537433e-01 0.813 0 0
Formation of definitive endoderm R-HSA-9823730 1.590184e-01 0.799 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.500503e-01 0.824 0 0
Cellular responses to stimuli R-HSA-8953897 1.070059e-01 0.971 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.286510e-01 0.368 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.008558e-01 0.522 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.156843e-01 0.501 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.041821e-01 0.393 0 0
Selective autophagy R-HSA-9663891 1.674336e-01 0.776 0 0
Macroautophagy R-HSA-1632852 2.531119e-01 0.597 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.464591e-01 0.608 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.800680e-01 0.420 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.860314e-01 0.544 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.620113e-01 0.441 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.041821e-01 0.393 0 0
Cellular Senescence R-HSA-2559583 4.086862e-01 0.389 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.803137e-02 1.055 0 0
Nuclear import of Rev protein R-HSA-180746 7.727647e-02 1.112 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.892634e-01 0.410 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.680359e-01 0.775 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.818621e-01 0.317 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.650710e-01 0.577 0 0
Recycling pathway of L1 R-HSA-437239 3.555692e-01 0.449 0 0
NRAGE signals death through JNK R-HSA-193648 4.647563e-01 0.333 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.659045e-01 0.332 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.815707e-01 0.418 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.976262e-01 0.401 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.613767e-01 0.336 0 0
G2/M Transition R-HSA-69275 4.481442e-01 0.349 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.888926e-01 0.410 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.888926e-01 0.410 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.888926e-01 0.410 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.722380e-01 0.764 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.612598e-01 0.336 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.029111e-01 0.395 0 0
ESR-mediated signaling R-HSA-8939211 2.493803e-01 0.603 0 0
G1/S Transition R-HSA-69206 3.610351e-01 0.442 0 0
Host Interactions of HIV factors R-HSA-162909 3.458310e-01 0.461 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.153665e-01 0.382 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.702636e-01 0.568 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.800680e-01 0.420 0 0
Signaling by FGFR in disease R-HSA-1226099 2.953681e-01 0.530 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.389129e-01 0.622 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.264263e-01 0.898 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.993253e-01 0.524 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.218339e-01 0.375 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.218339e-01 0.375 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.526694e-01 0.344 0 0
Sodium/Proton exchangers R-HSA-425986 4.526694e-01 0.344 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.818621e-01 0.317 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 4.041821e-01 0.393 0 0
Smooth Muscle Contraction R-HSA-445355 4.288696e-01 0.368 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.613767e-01 0.336 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.537520e-01 0.343 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.382647e-01 0.471 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.356480e-01 0.361 0 0
Mitotic Prophase R-HSA-68875 2.047598e-01 0.689 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.305254e-01 0.481 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.680359e-01 0.775 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.749077e-01 0.426 0 0
Semaphorin interactions R-HSA-373755 3.494093e-01 0.457 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.599606e-01 0.796 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.947178e-01 0.404 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.227169e-01 0.652 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.203271e-02 1.142 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.049617e-01 0.979 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.226793e-01 0.911 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.548601e-01 0.450 0 0
Formation of the anterior neural plate R-HSA-9823739 2.792096e-01 0.554 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.792096e-01 0.554 0 0
CHL1 interactions R-HSA-447041 4.218339e-01 0.375 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.218339e-01 0.375 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.526694e-01 0.344 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.404274e-01 0.853 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.818621e-01 0.317 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.818621e-01 0.317 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.818621e-01 0.317 0 0
Signaling by ROBO receptors R-HSA-376176 1.086546e-01 0.964 0 0
Carnitine shuttle R-HSA-200425 4.714857e-01 0.327 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.197822e-01 0.377 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.913403e-01 0.536 0 0
Influenza Infection R-HSA-168255 8.327060e-02 1.080 0 0
L1CAM interactions R-HSA-373760 2.862634e-01 0.543 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.713322e-01 0.566 0 0
Inositol phosphate metabolism R-HSA-1483249 2.436022e-01 0.613 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.851732e-01 0.414 0 0
DAG and IP3 signaling R-HSA-1489509 1.684056e-01 0.774 0 0
Calmodulin induced events R-HSA-111933 2.117915e-01 0.674 0 0
Signaling by TGFBR3 R-HSA-9839373 3.432781e-01 0.464 1 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.704913e-02 1.113 0 0
CaM pathway R-HSA-111997 2.117915e-01 0.674 0 0
Adrenoceptors R-HSA-390696 4.526694e-01 0.344 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.818621e-01 0.317 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.976262e-01 0.401 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.601577e-01 0.444 0 0
Potential therapeutics for SARS R-HSA-9679191 3.176781e-01 0.498 0 0
Apoptosis R-HSA-109581 1.941639e-01 0.712 0 0
Signaling by ERBB4 R-HSA-1236394 4.664895e-01 0.331 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.857552e-01 0.731 0 0
Gene Silencing by RNA R-HSA-211000 3.296009e-01 0.482 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.813188e-01 0.419 0 0
Ca-dependent events R-HSA-111996 2.943495e-01 0.531 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.973733e-01 0.705 0 0
tRNA processing in the nucleus R-HSA-6784531 3.387127e-01 0.470 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.535194e-01 0.343 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.187403e-01 0.497 0 0
RMTs methylate histone arginines R-HSA-3214858 3.187403e-01 0.497 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.006866e-02 1.045 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.252079e-01 0.902 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.218339e-01 0.375 0 0
Serine metabolism R-HSA-977347 4.352081e-01 0.361 0 0
Programmed Cell Death R-HSA-5357801 3.525409e-01 0.453 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.428053e-01 0.465 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.111601e-01 0.954 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.601577e-01 0.444 0 0
Interferon Signaling R-HSA-913531 1.719512e-01 0.765 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.156843e-01 0.501 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.818621e-01 0.317 0 0
Metal ion SLC transporters R-HSA-425410 3.678582e-01 0.434 0 0
Specification of primordial germ cells R-HSA-9827857 3.392271e-01 0.470 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.784015e-01 0.422 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.818621e-01 0.317 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.753123e-01 0.323 0 0
Syndecan interactions R-HSA-3000170 4.714857e-01 0.327 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.407781e-01 0.618 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.895884e-01 0.409 0 0
MHC class II antigen presentation R-HSA-2132295 2.232955e-01 0.651 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.852254e-01 0.314 0 0
Protein folding R-HSA-391251 4.862115e-01 0.313 0 0
Signaling by NOTCH1 R-HSA-1980143 4.872260e-01 0.312 0 0
UCH proteinases R-HSA-5689603 4.872260e-01 0.312 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.882300e-01 0.311 0 0
FLT3 Signaling R-HSA-9607240 4.890790e-01 0.311 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.890917e-01 0.311 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.890917e-01 0.311 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.890917e-01 0.311 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.890917e-01 0.311 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.938122e-01 0.306 0 0
Regulation of beta-cell development R-HSA-186712 4.998084e-01 0.301 0 0
TCR signaling R-HSA-202403 5.023547e-01 0.299 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.026669e-01 0.299 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.026669e-01 0.299 0 0
HIV Transcription Initiation R-HSA-167161 5.026669e-01 0.299 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.026669e-01 0.299 0 0
MAP2K and MAPK activation R-HSA-5674135 5.026669e-01 0.299 0 0
Intra-Golgi traffic R-HSA-6811438 5.026669e-01 0.299 0 0
Interferon gamma signaling R-HSA-877300 5.038357e-01 0.298 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.063249e-01 0.296 0 0
Hyaluronan degradation R-HSA-2160916 5.063249e-01 0.296 0 0
TGFBR3 expression R-HSA-9839394 5.063249e-01 0.296 0 0
Laminin interactions R-HSA-3000157 5.063249e-01 0.296 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.063249e-01 0.296 0 0
Interleukin-7 signaling R-HSA-1266695 5.063249e-01 0.296 0 0
PCP/CE pathway R-HSA-4086400 5.076691e-01 0.294 0 0
G alpha (12/13) signalling events R-HSA-416482 5.076691e-01 0.294 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.094994e-01 0.293 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.094994e-01 0.293 0 0
PI3K/AKT activation R-HSA-198203 5.094994e-01 0.293 0 0
Binding and entry of HIV virion R-HSA-173107 5.094994e-01 0.293 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.094994e-01 0.293 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.094994e-01 0.293 0 0
Pexophagy R-HSA-9664873 5.094994e-01 0.293 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.094994e-01 0.293 0 0
Josephin domain DUBs R-HSA-5689877 5.094994e-01 0.293 0 0
Signaling by Leptin R-HSA-2586552 5.094994e-01 0.293 0 0
Signaling by TGFB family members R-HSA-9006936 5.108962e-01 0.292 1 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.112718e-01 0.291 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.112718e-01 0.291 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.112718e-01 0.291 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.112718e-01 0.291 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.112718e-01 0.291 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.112718e-01 0.291 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.112718e-01 0.291 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.139707e-01 0.289 0 0
Platelet degranulation R-HSA-114608 5.160933e-01 0.287 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.226140e-01 0.282 0 0
PLC beta mediated events R-HSA-112043 5.226140e-01 0.282 0 0
MET activates PTK2 signaling R-HSA-8874081 5.231748e-01 0.281 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.231748e-01 0.281 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.231748e-01 0.281 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.231748e-01 0.281 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.231748e-01 0.281 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.276852e-01 0.278 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.292703e-01 0.276 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.338289e-01 0.273 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.338289e-01 0.273 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.356641e-01 0.271 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.356641e-01 0.271 0 0
vRNP Assembly R-HSA-192905 5.356641e-01 0.271 0 0
Bicarbonate transporters R-HSA-425381 5.356641e-01 0.271 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.356641e-01 0.271 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.356641e-01 0.271 0 0
PECAM1 interactions R-HSA-210990 5.356641e-01 0.271 0 0
Transport of RCbl within the body R-HSA-9758890 5.356641e-01 0.271 0 0
Prostanoid ligand receptors R-HSA-391908 5.356641e-01 0.271 0 0
Interleukin-2 signaling R-HSA-9020558 5.356641e-01 0.271 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.360195e-01 0.271 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.396334e-01 0.268 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.396334e-01 0.268 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.396334e-01 0.268 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.396334e-01 0.268 0 0
Vesicle-mediated transport R-HSA-5653656 5.460193e-01 0.263 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.485296e-01 0.261 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.525074e-01 0.258 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.550602e-01 0.256 0 0
Nucleosome assembly R-HSA-774815 5.550602e-01 0.256 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.550602e-01 0.256 0 0
Somitogenesis R-HSA-9824272 5.550602e-01 0.256 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.556944e-01 0.255 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.556944e-01 0.255 0 0
Insulin receptor signalling cascade R-HSA-74751 5.558557e-01 0.255 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.571723e-01 0.254 0 0
Signaling by NTRKs R-HSA-166520 5.571723e-01 0.254 0 0
DS-GAG biosynthesis R-HSA-2022923 5.604347e-01 0.251 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.604347e-01 0.251 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.604347e-01 0.251 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.604347e-01 0.251 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.604347e-01 0.251 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.604347e-01 0.251 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.604347e-01 0.251 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.604347e-01 0.251 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.604347e-01 0.251 0 0
Activation of RAC1 R-HSA-428540 5.604347e-01 0.251 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.604347e-01 0.251 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 5.604347e-01 0.251 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.666578e-01 0.247 0 0
Glycolysis R-HSA-70171 5.676332e-01 0.246 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.676341e-01 0.246 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.676341e-01 0.246 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.700274e-01 0.244 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.713535e-01 0.243 0 0
DARPP-32 events R-HSA-180024 5.713535e-01 0.243 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.713535e-01 0.243 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.713535e-01 0.243 0 0
Signaling by Erythropoietin R-HSA-9006335 5.713535e-01 0.243 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.713535e-01 0.243 0 0
Selenocysteine synthesis R-HSA-2408557 5.762978e-01 0.239 0 0
Mitochondrial biogenesis R-HSA-1592230 5.767488e-01 0.239 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.784818e-01 0.238 0 0
Translation R-HSA-72766 5.806940e-01 0.236 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.838852e-01 0.234 0 0
Maple Syrup Urine Disease R-HSA-9865114 5.838852e-01 0.234 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.838852e-01 0.234 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.838852e-01 0.234 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.838852e-01 0.234 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.838852e-01 0.234 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.838852e-01 0.234 0 0
Repression of WNT target genes R-HSA-4641265 5.838852e-01 0.234 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.838852e-01 0.234 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.838852e-01 0.234 0 0
MET activates RAS signaling R-HSA-8851805 5.838852e-01 0.234 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.838852e-01 0.234 0 0
OAS antiviral response R-HSA-8983711 5.838852e-01 0.234 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.848750e-01 0.233 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.848750e-01 0.233 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.857556e-01 0.232 0 0
Interleukin-37 signaling R-HSA-9008059 5.866077e-01 0.232 0 0
G-protein mediated events R-HSA-112040 5.878179e-01 0.231 0 0
Intraflagellar transport R-HSA-5620924 5.921147e-01 0.228 0 0
Co-stimulation by CD28 R-HSA-389356 5.921147e-01 0.228 0 0
GPER1 signaling R-HSA-9634597 5.921147e-01 0.228 0 0
Viral mRNA Translation R-HSA-192823 5.933623e-01 0.227 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.950376e-01 0.225 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.993594e-01 0.222 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.996050e-01 0.222 0 0
RNA Polymerase II Transcription R-HSA-73857 5.996181e-01 0.222 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.014558e-01 0.221 0 0
Trafficking of AMPA receptors R-HSA-399719 6.014558e-01 0.221 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.017574e-01 0.221 0 0
Opioid Signalling R-HSA-111885 6.017574e-01 0.221 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.040135e-01 0.219 0 0
Degradation of CDH1 R-HSA-9766229 6.040135e-01 0.219 0 0
Gap junction trafficking and regulation R-HSA-157858 6.040135e-01 0.219 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.040135e-01 0.219 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.060860e-01 0.217 0 0
Formation of axial mesoderm R-HSA-9796292 6.060860e-01 0.217 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.060860e-01 0.217 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.060860e-01 0.217 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.060860e-01 0.217 0 0
Maturation of nucleoprotein R-HSA-9683610 6.060860e-01 0.217 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.060860e-01 0.217 0 0
Interleukin-6 signaling R-HSA-1059683 6.060860e-01 0.217 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.060860e-01 0.217 0 0
Chromosome Maintenance R-HSA-73886 6.080593e-01 0.216 0 0
PI3K Cascade R-HSA-109704 6.156802e-01 0.211 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.156802e-01 0.211 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.158977e-01 0.210 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.158977e-01 0.210 0 0
DNA strand elongation R-HSA-69190 6.158977e-01 0.210 0 0
G0 and Early G1 R-HSA-1538133 6.158977e-01 0.210 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.183954e-01 0.209 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.183954e-01 0.209 0 0
Cellular response to starvation R-HSA-9711097 6.263037e-01 0.203 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 6.271036e-01 0.203 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.271036e-01 0.203 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.271036e-01 0.203 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.271036e-01 0.203 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.271036e-01 0.203 0 0
cGMP effects R-HSA-418457 6.271036e-01 0.203 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.271036e-01 0.203 0 0
Regulation of KIT signaling R-HSA-1433559 6.271036e-01 0.203 0 0
Signal regulatory protein family interactions R-HSA-391160 6.271036e-01 0.203 0 0
Zinc transporters R-HSA-435354 6.271036e-01 0.203 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.271036e-01 0.203 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.299343e-01 0.201 0 0
Nuclear RNA decay R-HSA-9930044 6.299343e-01 0.201 0 0
G-protein beta:gamma signalling R-HSA-397795 6.299343e-01 0.201 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.299343e-01 0.201 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.299343e-01 0.201 0 0
HCMV Early Events R-HSA-9609690 6.301628e-01 0.201 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.343736e-01 0.198 0 0
Synthesis of DNA R-HSA-69239 6.343736e-01 0.198 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.379727e-01 0.195 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.379727e-01 0.195 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.383085e-01 0.195 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.383085e-01 0.195 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.383085e-01 0.195 0 0
Neurexins and neuroligins R-HSA-6794361 6.383085e-01 0.195 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.383085e-01 0.195 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.396462e-01 0.194 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.435679e-01 0.191 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.470010e-01 0.189 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.470010e-01 0.189 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.470010e-01 0.189 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.470010e-01 0.189 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.470010e-01 0.189 0 0
DCC mediated attractive signaling R-HSA-418885 6.470010e-01 0.189 0 0
Erythropoietin activates RAS R-HSA-9027284 6.470010e-01 0.189 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.470010e-01 0.189 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.470010e-01 0.189 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.470010e-01 0.189 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.470010e-01 0.189 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.470010e-01 0.189 0 0
p38MAPK events R-HSA-171007 6.470010e-01 0.189 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.470010e-01 0.189 0 0
Protein methylation R-HSA-8876725 6.470010e-01 0.189 0 0
DNA Damage Reversal R-HSA-73942 6.470010e-01 0.189 0 0
Meiotic synapsis R-HSA-1221632 6.492668e-01 0.188 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.492668e-01 0.188 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.492668e-01 0.188 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.492668e-01 0.188 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.500784e-01 0.187 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.531087e-01 0.185 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.568015e-01 0.183 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.568015e-01 0.183 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.568015e-01 0.183 0 0
Hyaluronan metabolism R-HSA-2142845 6.568015e-01 0.183 0 0
Gap junction assembly R-HSA-190861 6.568015e-01 0.183 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.568015e-01 0.183 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.568015e-01 0.183 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.568015e-01 0.183 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.599867e-01 0.180 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.648984e-01 0.177 0 0
Phosphorylation of the APC/C R-HSA-176412 6.658378e-01 0.177 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.658378e-01 0.177 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.658378e-01 0.177 0 0
Killing mechanisms R-HSA-9664420 6.658378e-01 0.177 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.658378e-01 0.177 0 0
Negative regulation of FLT3 R-HSA-9706369 6.658378e-01 0.177 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.658378e-01 0.177 0 0
Protein ubiquitination R-HSA-8852135 6.660873e-01 0.176 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.667766e-01 0.176 0 0
Signalling to ERKs R-HSA-187687 6.696389e-01 0.174 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.704676e-01 0.174 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.735149e-01 0.172 0 0
Interleukin-12 signaling R-HSA-9020591 6.751200e-01 0.171 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.802251e-01 0.167 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.802546e-01 0.167 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.807098e-01 0.167 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.820848e-01 0.166 0 0
HSF1 activation R-HSA-3371511 6.820848e-01 0.166 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 6.820848e-01 0.166 0 0
G1/S-Specific Transcription R-HSA-69205 6.820848e-01 0.166 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.820848e-01 0.166 0 0
SLC transporter disorders R-HSA-5619102 6.832947e-01 0.165 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.836706e-01 0.165 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.836706e-01 0.165 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.836706e-01 0.165 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.836706e-01 0.165 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.836706e-01 0.165 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.836706e-01 0.165 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.836706e-01 0.165 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.836706e-01 0.165 0 0
Synthesis of PG R-HSA-1483148 6.836706e-01 0.165 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.836706e-01 0.165 0 0
IRS-mediated signalling R-HSA-112399 6.907135e-01 0.161 0 0
ABC transporter disorders R-HSA-5619084 6.926724e-01 0.159 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.941442e-01 0.159 0 0
Degradation of DVL R-HSA-4641258 6.941442e-01 0.159 0 0
Degradation of AXIN R-HSA-4641257 6.941442e-01 0.159 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.005527e-01 0.155 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.005527e-01 0.155 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.005527e-01 0.155 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.005527e-01 0.155 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.005527e-01 0.155 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.005527e-01 0.155 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.020493e-01 0.154 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.058231e-01 0.151 0 0
Cilium Assembly R-HSA-5617833 7.076024e-01 0.150 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.100094e-01 0.149 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.165348e-01 0.145 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.165348e-01 0.145 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.165348e-01 0.145 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.165348e-01 0.145 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.165348e-01 0.145 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.165348e-01 0.145 0 0
GAB1 signalosome R-HSA-180292 7.165348e-01 0.145 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.165348e-01 0.145 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.165348e-01 0.145 0 0
Tie2 Signaling R-HSA-210993 7.165348e-01 0.145 0 0
Stabilization of p53 R-HSA-69541 7.171277e-01 0.144 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.171277e-01 0.144 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.177152e-01 0.144 0 0
DNA Replication R-HSA-69306 7.185596e-01 0.144 0 0
FOXO-mediated transcription R-HSA-9614085 7.191923e-01 0.143 0 0
Glucose metabolism R-HSA-70326 7.221815e-01 0.141 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.241297e-01 0.140 0 0
Hedgehog 'off' state R-HSA-5610787 7.264118e-01 0.139 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.280646e-01 0.138 0 0
Diseases of Immune System R-HSA-5260271 7.280646e-01 0.138 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.280646e-01 0.138 0 0
Interleukin-2 family signaling R-HSA-451927 7.280646e-01 0.138 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.283658e-01 0.138 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.316648e-01 0.136 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.316648e-01 0.136 0 0
Rap1 signalling R-HSA-392517 7.316648e-01 0.136 0 0
Pyrimidine biosynthesis R-HSA-500753 7.316648e-01 0.136 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.316648e-01 0.136 0 0
Translesion Synthesis by POLH R-HSA-110320 7.316648e-01 0.136 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.316648e-01 0.136 0 0
Other interleukin signaling R-HSA-449836 7.316648e-01 0.136 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.316648e-01 0.136 0 0
Maturation of nucleoprotein R-HSA-9694631 7.316648e-01 0.136 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.316648e-01 0.136 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.316648e-01 0.136 0 0
Interleukin-1 signaling R-HSA-9020702 7.334968e-01 0.135 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.335558e-01 0.135 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.371963e-01 0.132 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.371963e-01 0.132 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.371963e-01 0.132 0 0
Signaling by PDGF R-HSA-186797 7.371963e-01 0.132 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.371963e-01 0.132 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.386409e-01 0.132 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.386409e-01 0.132 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.412215e-01 0.130 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.441659e-01 0.128 0 0
Signaling by PTK6 R-HSA-8848021 7.457981e-01 0.127 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.457981e-01 0.127 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.459881e-01 0.127 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.459881e-01 0.127 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.459881e-01 0.127 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.459881e-01 0.127 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.459881e-01 0.127 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.459881e-01 0.127 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.459881e-01 0.127 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.459881e-01 0.127 0 0
Creatine metabolism R-HSA-71288 7.459881e-01 0.127 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.459881e-01 0.127 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.470323e-01 0.127 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.487187e-01 0.126 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.488639e-01 0.126 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.488639e-01 0.126 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.488639e-01 0.126 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.488639e-01 0.126 0 0
Signaling by WNT R-HSA-195721 7.538379e-01 0.123 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.560485e-01 0.121 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.587412e-01 0.120 0 0
Co-inhibition by PD-1 R-HSA-389948 7.589781e-01 0.120 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.595477e-01 0.119 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.595477e-01 0.119 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.595477e-01 0.119 0 0
Lagging Strand Synthesis R-HSA-69186 7.595477e-01 0.119 0 0
Signaling by NOTCH R-HSA-157118 7.618599e-01 0.118 0 0
Neutrophil degranulation R-HSA-6798695 7.629776e-01 0.117 0 0
SARS-CoV Infections R-HSA-9679506 7.646152e-01 0.117 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.682805e-01 0.114 0 0
Signaling by SCF-KIT R-HSA-1433557 7.682805e-01 0.114 0 0
Interleukin-12 family signaling R-HSA-447115 7.702110e-01 0.113 0 0
CS-GAG biosynthesis R-HSA-2022870 7.723842e-01 0.112 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.723842e-01 0.112 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.723842e-01 0.112 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.723842e-01 0.112 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.723842e-01 0.112 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.732044e-01 0.112 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.746943e-01 0.111 0 0
Netrin-1 signaling R-HSA-373752 7.774898e-01 0.109 0 0
Surfactant metabolism R-HSA-5683826 7.774898e-01 0.109 0 0
Methylation R-HSA-156581 7.774898e-01 0.109 0 0
Gap junction trafficking R-HSA-190828 7.774898e-01 0.109 0 0
Amine ligand-binding receptors R-HSA-375280 7.774898e-01 0.109 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.845362e-01 0.105 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.845362e-01 0.105 0 0
Ethanol oxidation R-HSA-71384 7.845362e-01 0.105 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.845362e-01 0.105 0 0
LDL clearance R-HSA-8964038 7.845362e-01 0.105 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.853885e-01 0.105 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.863770e-01 0.104 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.863770e-01 0.104 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.863770e-01 0.104 0 0
Base Excision Repair R-HSA-73884 7.902349e-01 0.102 0 0
Cellular response to chemical stress R-HSA-9711123 7.939196e-01 0.100 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.949504e-01 0.100 0 0
Diseases of DNA repair R-HSA-9675135 7.949504e-01 0.100 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.952788e-01 0.099 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.960401e-01 0.099 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 7.960401e-01 0.099 0 0
Growth hormone receptor signaling R-HSA-982772 7.960401e-01 0.099 0 0
COPII-mediated vesicle transport R-HSA-204005 7.998399e-01 0.097 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.998399e-01 0.097 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.032180e-01 0.095 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.032180e-01 0.095 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.032180e-01 0.095 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.067173e-01 0.093 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.067173e-01 0.093 0 0
Hedgehog 'on' state R-HSA-5632684 8.067173e-01 0.093 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.067173e-01 0.093 0 0
Complex III assembly R-HSA-9865881 8.069304e-01 0.093 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.069304e-01 0.093 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.069304e-01 0.093 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.069304e-01 0.093 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.069304e-01 0.093 0 0
Neurodegenerative Diseases R-HSA-8863678 8.069304e-01 0.093 0 0
Interleukin-6 family signaling R-HSA-6783589 8.069304e-01 0.093 0 0
Signaling by Insulin receptor R-HSA-74752 8.088372e-01 0.092 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.111881e-01 0.091 0 0
Toll-like Receptor Cascades R-HSA-168898 8.113429e-01 0.091 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.133944e-01 0.090 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.147312e-01 0.089 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.160405e-01 0.088 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.172399e-01 0.088 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.172399e-01 0.088 0 0
Tight junction interactions R-HSA-420029 8.172399e-01 0.088 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.172399e-01 0.088 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.172399e-01 0.088 0 0
Formation of the nephric duct R-HSA-9830364 8.172399e-01 0.088 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.172399e-01 0.088 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 8.172399e-01 0.088 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.188688e-01 0.087 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.188688e-01 0.087 0 0
DNA Damage Bypass R-HSA-73893 8.188688e-01 0.087 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.188688e-01 0.087 0 0
Circadian clock R-HSA-9909396 8.195703e-01 0.086 0 0
Ca2+ pathway R-HSA-4086398 8.198752e-01 0.086 0 0
Interleukin-1 family signaling R-HSA-446652 8.215600e-01 0.085 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.262683e-01 0.083 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.269995e-01 0.082 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.269995e-01 0.082 0 0
Metalloprotease DUBs R-HSA-5689901 8.269995e-01 0.082 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.269995e-01 0.082 0 0
Sphingolipid catabolism R-HSA-9845614 8.269995e-01 0.082 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.269995e-01 0.082 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.269995e-01 0.082 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.333948e-01 0.079 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.333948e-01 0.079 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.340047e-01 0.079 0 0
Cristae formation R-HSA-8949613 8.362385e-01 0.078 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.362385e-01 0.078 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.362385e-01 0.078 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.362385e-01 0.078 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.362385e-01 0.078 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.362385e-01 0.078 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.362385e-01 0.078 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.362385e-01 0.078 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.366958e-01 0.077 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.368316e-01 0.077 0 0
Generic Transcription Pathway R-HSA-212436 8.368541e-01 0.077 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.402563e-01 0.076 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.402563e-01 0.076 0 0
Transmission across Chemical Synapses R-HSA-112315 8.417903e-01 0.075 0 0
Telomere Maintenance R-HSA-157579 8.419993e-01 0.075 0 0
Integration of energy metabolism R-HSA-163685 8.424363e-01 0.074 0 0
Telomere Extension By Telomerase R-HSA-171319 8.449845e-01 0.073 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.449845e-01 0.073 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.468606e-01 0.072 0 0
Integrin cell surface interactions R-HSA-216083 8.494677e-01 0.071 0 0
Signaling by Hedgehog R-HSA-5358351 8.509008e-01 0.070 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.532158e-01 0.069 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.532640e-01 0.069 0 0
ABC-family proteins mediated transport R-HSA-382556 8.566826e-01 0.067 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.569347e-01 0.067 0 0
PKR-mediated signaling R-HSA-9833482 8.600663e-01 0.065 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.611018e-01 0.065 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.611018e-01 0.065 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.611018e-01 0.065 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.611018e-01 0.065 0 0
Activation of BH3-only proteins R-HSA-114452 8.611018e-01 0.065 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.611289e-01 0.065 0 0
Ion homeostasis R-HSA-5578775 8.652096e-01 0.063 0 0
PI Metabolism R-HSA-1483255 8.658131e-01 0.063 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.685213e-01 0.061 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.685213e-01 0.061 0 0
Downstream signal transduction R-HSA-186763 8.685213e-01 0.061 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.685213e-01 0.061 0 0
Selenoamino acid metabolism R-HSA-2408522 8.693015e-01 0.061 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.708633e-01 0.060 0 0
HCMV Infection R-HSA-9609646 8.729924e-01 0.059 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.755450e-01 0.058 0 0
Signaling by WNT in cancer R-HSA-4791275 8.755450e-01 0.058 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.755450e-01 0.058 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.785712e-01 0.056 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.785712e-01 0.056 0 0
Peroxisomal protein import R-HSA-9033241 8.815214e-01 0.055 0 0
Extension of Telomeres R-HSA-180786 8.815214e-01 0.055 0 0
Sialic acid metabolism R-HSA-4085001 8.815214e-01 0.055 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.821938e-01 0.054 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.821938e-01 0.054 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.821938e-01 0.054 0 0
Cardiogenesis R-HSA-9733709 8.821938e-01 0.054 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.821938e-01 0.054 0 0
Meiosis R-HSA-1500620 8.837437e-01 0.054 0 0
Striated Muscle Contraction R-HSA-390522 8.884878e-01 0.051 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.884878e-01 0.051 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.884878e-01 0.051 0 0
CS/DS degradation R-HSA-2024101 8.884878e-01 0.051 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.884878e-01 0.051 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.884878e-01 0.051 0 0
Adaptive Immune System R-HSA-1280218 8.889536e-01 0.051 0 0
Dual Incision in GG-NER R-HSA-5696400 8.944460e-01 0.048 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.944460e-01 0.048 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.944460e-01 0.048 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.944460e-01 0.048 0 0
eNOS activation R-HSA-203615 8.944460e-01 0.048 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.944460e-01 0.048 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.944460e-01 0.048 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.944460e-01 0.048 0 0
Mitophagy R-HSA-5205647 8.944460e-01 0.048 0 0
Neuronal System R-HSA-112316 8.948433e-01 0.048 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.980461e-01 0.047 0 0
Developmental Biology R-HSA-1266738 8.983400e-01 0.047 1 0
Post-translational protein modification R-HSA-597592 8.994585e-01 0.046 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.998283e-01 0.046 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.000861e-01 0.046 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.000861e-01 0.046 0 0
Oncogene Induced Senescence R-HSA-2559585 9.000861e-01 0.046 0 0
Regulation of Apoptosis R-HSA-169911 9.000861e-01 0.046 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.004373e-01 0.046 0 0
Reproduction R-HSA-1474165 9.012233e-01 0.045 0 0
ER-Phagosome pathway R-HSA-1236974 9.037824e-01 0.044 0 0
Adipogenesis R-HSA-9843745 9.043142e-01 0.044 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.047055e-01 0.043 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.054251e-01 0.043 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.054251e-01 0.043 0 0
Glycosphingolipid transport R-HSA-9845576 9.054251e-01 0.043 0 0
GPVI-mediated activation cascade R-HSA-114604 9.054251e-01 0.043 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.060013e-01 0.043 0 0
Neurotransmitter release cycle R-HSA-112310 9.073949e-01 0.042 0 0
Downstream TCR signaling R-HSA-202424 9.073949e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.088022e-01 0.042 0 0
Voltage gated Potassium channels R-HSA-1296072 9.104792e-01 0.041 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.104792e-01 0.041 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.104792e-01 0.041 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.152635e-01 0.038 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.152635e-01 0.038 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.152635e-01 0.038 0 0
Signaling by Interleukins R-HSA-449147 9.159489e-01 0.038 0 0
HCMV Late Events R-HSA-9610379 9.166568e-01 0.038 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.197923e-01 0.036 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.197923e-01 0.036 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.197923e-01 0.036 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.197923e-01 0.036 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.201240e-01 0.036 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.236778e-01 0.034 0 0
Collagen formation R-HSA-1474290 9.236778e-01 0.034 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.236795e-01 0.034 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.240794e-01 0.034 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.240794e-01 0.034 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.240794e-01 0.034 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.240794e-01 0.034 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.240794e-01 0.034 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.269225e-01 0.033 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.281376e-01 0.032 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.281376e-01 0.032 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.281376e-01 0.032 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.281376e-01 0.032 0 0
ECM proteoglycans R-HSA-3000178 9.301133e-01 0.031 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.319790e-01 0.031 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.319790e-01 0.031 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.319790e-01 0.031 0 0
Translation of Structural Proteins R-HSA-9683701 9.319790e-01 0.031 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.321447e-01 0.031 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.321447e-01 0.031 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.331721e-01 0.030 0 0
Viral Infection Pathways R-HSA-9824446 9.350607e-01 0.029 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.356154e-01 0.029 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.356154e-01 0.029 0 0
Ion channel transport R-HSA-983712 9.373398e-01 0.028 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.394886e-01 0.027 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.416054e-01 0.026 0 0
Proteasome assembly R-HSA-9907900 9.423159e-01 0.026 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.423159e-01 0.026 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.423159e-01 0.026 0 0
G1 Phase R-HSA-69236 9.423159e-01 0.026 0 0
Cyclin D associated events in G1 R-HSA-69231 9.423159e-01 0.026 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.423159e-01 0.026 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.454002e-01 0.024 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.454002e-01 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.454002e-01 0.024 0 0
tRNA processing R-HSA-72306 9.461064e-01 0.024 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.477854e-01 0.023 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.477854e-01 0.023 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.477854e-01 0.023 0 0
G alpha (s) signalling events R-HSA-418555 9.478017e-01 0.023 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.479861e-01 0.023 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.483198e-01 0.023 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.486439e-01 0.023 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.490208e-01 0.023 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.490208e-01 0.023 0 0
Interleukin-10 signaling R-HSA-6783783 9.490208e-01 0.023 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.506703e-01 0.022 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.510834e-01 0.022 0 0
Synthesis of PC R-HSA-1483191 9.510834e-01 0.022 0 0
Sensory processing of sound R-HSA-9659379 9.512865e-01 0.022 0 0
Hemostasis R-HSA-109582 9.536652e-01 0.021 0 0
Gluconeogenesis R-HSA-70263 9.536994e-01 0.021 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.561756e-01 0.019 0 0
Azathioprine ADME R-HSA-9748787 9.585196e-01 0.018 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.597295e-01 0.018 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.607383e-01 0.017 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.607383e-01 0.017 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.611918e-01 0.017 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.625810e-01 0.017 0 0
Nucleotide biosynthesis R-HSA-8956320 9.648264e-01 0.016 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.658270e-01 0.015 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.684893e-01 0.014 0 0
G alpha (z) signalling events R-HSA-418597 9.684893e-01 0.014 0 0
Muscle contraction R-HSA-397014 9.701634e-01 0.013 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.701753e-01 0.013 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.701753e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.701753e-01 0.013 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.701753e-01 0.013 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.732817e-01 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.732817e-01 0.012 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.734651e-01 0.012 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.751634e-01 0.011 0 0
tRNA Aminoacylation R-HSA-379724 9.760649e-01 0.011 0 0
Metabolism of polyamines R-HSA-351202 9.760649e-01 0.011 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.773459e-01 0.010 0 0
Neddylation R-HSA-8951664 9.777169e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.780678e-01 0.010 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.781242e-01 0.010 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.801648e-01 0.009 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.803995e-01 0.009 0 0
Potassium Channels R-HSA-1296071 9.807204e-01 0.008 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.807925e-01 0.008 0 0
Sphingolipid metabolism R-HSA-428157 9.808790e-01 0.008 0 0
Formation of the cornified envelope R-HSA-6809371 9.809892e-01 0.008 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.821686e-01 0.008 0 0
Regulation of insulin secretion R-HSA-422356 9.824557e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.827940e-01 0.008 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.837153e-01 0.007 0 0
Kidney development R-HSA-9830369 9.837153e-01 0.007 0 0
Nicotinate metabolism R-HSA-196807 9.837153e-01 0.007 0 0
Regulated Necrosis R-HSA-5218859 9.845872e-01 0.007 0 0
Metabolism of proteins R-HSA-392499 9.849137e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.852540e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.861937e-01 0.006 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.861937e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.869330e-01 0.006 0 0
Metabolism of cofactors R-HSA-8978934 9.869330e-01 0.006 0 0
Retinoid metabolism and transport R-HSA-975634 9.869330e-01 0.006 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.869554e-01 0.006 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.870728e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.874138e-01 0.006 0 0
Aspirin ADME R-HSA-9749641 9.882952e-01 0.005 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.895156e-01 0.005 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.895156e-01 0.005 0 0
Immune System R-HSA-168256 9.895460e-01 0.005 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.906088e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 9.906088e-01 0.004 0 0
Mitochondrial translation R-HSA-5368287 9.908711e-01 0.004 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.915882e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.916373e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.916373e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.916373e-01 0.004 0 0
Amyloid fiber formation R-HSA-977225 9.924655e-01 0.003 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.924655e-01 0.003 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.928693e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.932514e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.932582e-01 0.003 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.944462e-01 0.002 0 0
Developmental Cell Lineages R-HSA-9734767 9.947528e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.948601e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.948763e-01 0.002 0 0
Diseases of programmed cell death R-HSA-9645723 9.951510e-01 0.002 0 0
Protein localization R-HSA-9609507 9.955049e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.956571e-01 0.002 0 0
Peptide ligand-binding receptors R-HSA-375276 9.960260e-01 0.002 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.962436e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.963189e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.963189e-01 0.002 0 0
G alpha (i) signalling events R-HSA-418594 9.968532e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.968727e-01 0.001 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.969154e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.971980e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.972058e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.974976e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.976318e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.978608e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.984768e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.986028e-01 0.001 0 0
Stimuli-sensing channels R-HSA-2672351 9.986360e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.986654e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.987092e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.987785e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.988441e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.989554e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.991044e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.991700e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992568e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.993130e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.994664e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.994733e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.995722e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.996325e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.996376e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996443e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.997488e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.997488e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998865e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.998944e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.998982e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999140e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999337e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999381e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999707e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999718e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999732e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999746e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999746e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999788e-01 0.000 0 0
Disease R-HSA-1643685 9.999805e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999807e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999841e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999889e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999905e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999952e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999974e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999997e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999999e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Signaling by NODAL R-HSA-1181150 1.000000e+00 0.000 1 1
Regulation of signaling by NODAL R-HSA-1433617 1.000000e+00 0.000 1 1
Signaling by Activin R-HSA-1502540 1.000000e+00 0.000 1 1
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
TGFBR3 regulates activin signaling R-HSA-9839406 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.376677e-14 13.861 0 0
Metabolism of RNA R-HSA-8953854 6.395107e-12 11.194 0 0
M Phase R-HSA-68886 3.317202e-11 10.479 0 0
Cell Cycle, Mitotic R-HSA-69278 9.280487e-11 10.032 0 0
Cell-Cell communication R-HSA-1500931 1.357560e-10 9.867 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.894596e-10 9.722 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.134626e-09 8.945 0 0
Signaling by ALK in cancer R-HSA-9700206 1.134626e-09 8.945 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.370304e-09 8.863 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.370304e-09 8.863 0 0
Cell Cycle Checkpoints R-HSA-69620 9.091029e-09 8.041 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.006610e-08 7.997 0 0
Cell junction organization R-HSA-446728 1.202940e-08 7.920 0 0
Mitotic Anaphase R-HSA-68882 1.797854e-08 7.745 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.078979e-08 7.682 0 0
Adherens junctions interactions R-HSA-418990 2.401503e-08 7.620 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.279283e-08 7.484 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.617230e-08 7.017 0 0
Apoptosis R-HSA-109581 1.206805e-07 6.918 0 0
Cellular responses to stimuli R-HSA-8953897 1.652964e-07 6.782 0 0
Cell-cell junction organization R-HSA-421270 1.813038e-07 6.742 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.018964e-07 6.695 0 0
G2/M Checkpoints R-HSA-69481 3.461083e-07 6.461 0 0
Separation of Sister Chromatids R-HSA-2467813 3.947396e-07 6.404 0 0
Apoptotic execution phase R-HSA-75153 5.278248e-07 6.278 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.001122e-06 6.000 0 0
Mitotic Prometaphase R-HSA-68877 9.999259e-07 6.000 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.112337e-06 5.954 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.333022e-06 5.875 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.340236e-06 5.873 0 0
Chromatin organization R-HSA-4839726 1.294328e-06 5.888 0 0
Nervous system development R-HSA-9675108 1.496572e-06 5.825 0 0
Cellular response to heat stress R-HSA-3371556 1.739452e-06 5.760 0 0
Chromatin modifying enzymes R-HSA-3247509 1.970647e-06 5.705 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.039759e-06 5.690 0 0
Axon guidance R-HSA-422475 2.125575e-06 5.673 0 0
Cellular responses to stress R-HSA-2262752 2.817055e-06 5.550 0 0
Regulation of CDH1 Function R-HSA-9764561 3.037850e-06 5.517 0 0
Josephin domain DUBs R-HSA-5689877 3.528167e-06 5.452 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.761862e-06 5.322 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.761862e-06 5.322 0 0
Programmed Cell Death R-HSA-5357801 5.102948e-06 5.292 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.730989e-06 5.242 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.290360e-05 4.889 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.277460e-05 4.894 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.553141e-05 4.809 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.631976e-05 4.787 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.753949e-05 4.756 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.895915e-05 4.722 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.129790e-05 4.672 0 0
Signaling by RAS mutants R-HSA-6802949 2.276370e-05 4.643 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.276370e-05 4.643 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.276370e-05 4.643 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.276370e-05 4.643 0 0
HSF1-dependent transactivation R-HSA-3371571 2.359360e-05 4.627 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.501318e-05 4.602 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.501318e-05 4.602 0 0
rRNA processing R-HSA-72312 2.495718e-05 4.603 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.702966e-05 4.568 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.898491e-05 4.538 0 0
Signaling by ROBO receptors R-HSA-376176 3.043829e-05 4.517 0 0
Influenza Infection R-HSA-168255 3.448577e-05 4.462 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.453052e-05 4.462 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.954892e-05 4.403 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.855511e-05 4.314 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.589993e-05 4.253 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.534890e-05 4.257 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.607188e-05 4.251 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.665865e-05 4.247 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.793246e-05 4.237 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.070680e-05 4.217 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.070680e-05 4.217 0 0
Regulation of TP53 Activity R-HSA-5633007 6.049825e-05 4.218 0 0
L1CAM interactions R-HSA-373760 6.348928e-05 4.197 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.117091e-05 4.148 0 0
Ribosome-associated quality control R-HSA-9948299 7.298966e-05 4.137 0 0
G2/M Transition R-HSA-69275 7.488664e-05 4.126 0 0
Striated Muscle Contraction R-HSA-390522 7.992509e-05 4.097 0 0
Cellular Senescence R-HSA-2559583 7.768090e-05 4.110 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.706405e-05 4.060 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.257900e-05 4.033 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.036878e-04 3.984 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.107048e-04 3.956 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.346285e-04 3.871 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.333517e-04 3.875 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.357787e-04 3.867 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.398438e-04 3.854 0 0
ESR-mediated signaling R-HSA-8939211 1.423321e-04 3.847 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.426212e-04 3.846 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.707698e-04 3.768 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.786459e-04 3.748 0 0
Peptide chain elongation R-HSA-156902 1.945420e-04 3.711 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.011893e-04 3.696 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.090852e-04 3.680 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.206458e-04 3.656 0 0
Signaling by TGFB family members R-HSA-9006936 2.465050e-04 3.608 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.484711e-04 3.605 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.684870e-04 3.571 0 0
mRNA Splicing R-HSA-72172 2.624334e-04 3.581 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.561085e-04 3.592 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.717388e-04 3.566 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.719295e-04 3.566 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.723255e-04 3.565 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.774529e-04 3.557 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.928565e-04 3.533 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.033363e-04 3.518 0 0
Muscle contraction R-HSA-397014 2.983238e-04 3.525 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.113702e-04 3.507 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.113702e-04 3.507 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.146428e-04 3.502 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.304894e-04 3.481 0 0
Membrane Trafficking R-HSA-199991 3.493347e-04 3.457 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.499913e-04 3.456 0 0
Translation initiation complex formation R-HSA-72649 3.779916e-04 3.423 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.909906e-04 3.408 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.974888e-04 3.401 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.066015e-04 3.391 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.079790e-04 3.389 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.097348e-04 3.387 0 0
Signaling by ERBB2 R-HSA-1227986 4.189988e-04 3.378 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.379782e-04 3.359 0 0
Mitotic Prophase R-HSA-68875 5.001409e-04 3.301 0 0
Signal Transduction R-HSA-162582 5.132314e-04 3.290 1 0
Signaling by EGFR R-HSA-177929 5.434883e-04 3.265 0 0
MAP2K and MAPK activation R-HSA-5674135 6.617127e-04 3.179 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.281156e-04 3.202 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.653865e-04 3.177 0 0
Eukaryotic Translation Termination R-HSA-72764 6.908736e-04 3.161 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.957576e-04 3.158 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.773932e-04 3.109 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.773932e-04 3.109 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.427529e-04 3.074 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.427529e-04 3.074 0 0
Homology Directed Repair R-HSA-5693538 8.166614e-04 3.088 0 0
Smooth Muscle Contraction R-HSA-445355 8.416224e-04 3.075 0 0
Gene expression (Transcription) R-HSA-74160 8.314867e-04 3.080 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.547276e-04 3.068 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.697858e-04 3.061 0 0
Post NMDA receptor activation events R-HSA-438064 9.019268e-04 3.045 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 9.702261e-04 3.013 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.736584e-04 3.012 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.813624e-04 3.008 0 0
Signaling by VEGF R-HSA-194138 9.845151e-04 3.007 0 0
Degradation of CDH1 R-HSA-9766229 1.094195e-03 2.961 0 0
Signaling by Hippo R-HSA-2028269 1.129092e-03 2.947 0 0
Activation of BH3-only proteins R-HSA-114452 1.087952e-03 2.963 0 0
Interleukin-37 signaling R-HSA-9008059 1.087952e-03 2.963 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.135371e-03 2.945 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.251936e-03 2.902 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.251936e-03 2.902 0 0
Aggrephagy R-HSA-9646399 1.266363e-03 2.897 0 0
Attenuation phase R-HSA-3371568 1.266363e-03 2.897 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.284877e-03 2.891 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.284877e-03 2.891 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.371899e-03 2.863 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.371899e-03 2.863 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.525612e-03 2.817 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.532964e-03 2.814 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.532964e-03 2.814 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.488611e-03 2.827 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.515496e-03 2.819 0 0
HSF1 activation R-HSA-3371511 1.631684e-03 2.787 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.699230e-03 2.770 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.701048e-03 2.769 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.701048e-03 2.769 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.707606e-03 2.768 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.749420e-03 2.757 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.749420e-03 2.757 0 0
Formation of annular gap junctions R-HSA-196025 1.829327e-03 2.738 0 0
mRNA 3'-end processing R-HSA-72187 1.824519e-03 2.739 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.914239e-03 2.718 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.001905e-03 2.699 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.003861e-03 2.698 0 0
Deubiquitination R-HSA-5688426 1.820197e-03 2.740 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.829327e-03 2.738 0 0
S Phase R-HSA-69242 1.890390e-03 2.723 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.889628e-03 2.724 0 0
Recycling pathway of L1 R-HSA-437239 2.019342e-03 2.695 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.026869e-03 2.693 0 0
Selective autophagy R-HSA-9663891 2.235543e-03 2.651 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.279633e-03 2.642 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.388077e-03 2.622 0 0
PTEN Regulation R-HSA-6807070 2.554671e-03 2.593 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.585862e-03 2.587 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.586428e-03 2.587 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.625788e-03 2.581 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.651426e-03 2.577 0 0
Nephrin family interactions R-HSA-373753 2.651426e-03 2.577 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.689392e-03 2.570 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.689392e-03 2.570 0 0
Repression of WNT target genes R-HSA-4641265 2.698481e-03 2.569 0 0
Gap junction degradation R-HSA-190873 2.804931e-03 2.552 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.804931e-03 2.552 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.804931e-03 2.552 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.123813e-03 2.505 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.316463e-03 2.479 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.014776e-03 2.521 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.352838e-03 2.475 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.006302e-03 2.522 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.365421e-03 2.473 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.395431e-03 2.469 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.395431e-03 2.469 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.432418e-03 2.464 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.432418e-03 2.464 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.453893e-03 2.462 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.569354e-03 2.447 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.689135e-03 2.433 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.746749e-03 2.426 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.003035e-03 2.398 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.007651e-03 2.397 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 4.007651e-03 2.397 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.094965e-03 2.388 0 0
Interferon Signaling R-HSA-913531 4.103646e-03 2.387 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.217717e-03 2.375 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.217717e-03 2.375 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.463607e-03 2.350 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.653720e-03 2.332 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.981996e-03 2.303 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.522124e-03 2.345 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.522124e-03 2.345 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.657665e-03 2.332 0 0
Signaling by NOTCH R-HSA-157118 4.535497e-03 2.343 0 0
Interleukin-12 signaling R-HSA-9020591 4.396556e-03 2.357 0 0
Nucleotide Excision Repair R-HSA-5696398 5.024447e-03 2.299 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.055239e-03 2.296 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.164204e-03 2.287 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.164204e-03 2.287 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.194304e-03 2.284 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.258340e-03 2.279 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.388231e-03 2.269 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.405298e-03 2.267 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.461101e-03 2.263 0 0
mTORC1-mediated signalling R-HSA-166208 5.471663e-03 2.262 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.471663e-03 2.262 0 0
RNA Polymerase I Transcription R-HSA-73864 5.589957e-03 2.253 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.589957e-03 2.253 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.748153e-03 2.240 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.737818e-03 2.171 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.925161e-03 2.227 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.484560e-03 2.188 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.484560e-03 2.188 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.123021e-03 2.213 0 0
DNA Double Strand Break Response R-HSA-5693606 6.654510e-03 2.177 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.802973e-03 2.236 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.857532e-03 2.232 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.381258e-03 2.195 0 0
Protein methylation R-HSA-8876725 6.737818e-03 2.171 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.925161e-03 2.227 0 0
MAPK family signaling cascades R-HSA-5683057 6.115945e-03 2.214 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.469933e-03 2.189 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.925161e-03 2.227 0 0
p75NTR signals via NF-kB R-HSA-193639 6.737818e-03 2.171 0 0
Regulation of PTEN localization R-HSA-8948747 6.191447e-03 2.208 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.951240e-03 2.225 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.737818e-03 2.171 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.925161e-03 2.227 0 0
Selenocysteine synthesis R-HSA-2408557 5.853270e-03 2.233 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.255033e-03 2.204 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.775889e-03 2.169 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.832109e-03 2.165 0 0
HDACs deacetylate histones R-HSA-3214815 6.832109e-03 2.165 0 0
Regulation of signaling by CBL R-HSA-912631 6.966053e-03 2.157 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.966053e-03 2.157 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.082500e-03 2.150 0 0
Signaling by WNT R-HSA-195721 7.083907e-03 2.150 0 0
Viral mRNA Translation R-HSA-192823 7.139075e-03 2.146 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.387240e-03 2.132 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.513493e-03 2.124 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.513493e-03 2.124 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.513493e-03 2.124 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.700664e-03 2.113 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.768849e-03 2.110 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.814465e-03 2.107 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.863918e-03 2.104 0 0
NF-kB is activated and signals survival R-HSA-209560 8.066968e-03 2.093 0 0
Centrosome maturation R-HSA-380287 8.187151e-03 2.087 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.099170e-03 2.041 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 9.099170e-03 2.041 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 9.099170e-03 2.041 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 9.099170e-03 2.041 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.764666e-03 2.057 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.764666e-03 2.057 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.764666e-03 2.057 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.764666e-03 2.057 0 0
RAF activation R-HSA-5673000 8.413521e-03 2.075 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.928061e-03 2.003 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.797603e-03 2.056 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.164113e-03 2.038 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.797603e-03 2.056 0 0
Nuclear import of Rev protein R-HSA-180746 8.413521e-03 2.075 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.413521e-03 2.075 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.773159e-03 2.057 0 0
Negative regulation of MET activity R-HSA-6807004 8.764666e-03 2.057 0 0
DAG and IP3 signaling R-HSA-1489509 8.977576e-03 2.047 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.928061e-03 2.003 0 0
Signal transduction by L1 R-HSA-445144 8.764666e-03 2.057 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 9.099170e-03 2.041 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.803139e-03 2.055 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.413521e-03 2.075 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.928061e-03 2.003 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.099170e-03 2.041 0 0
Interleukin-12 family signaling R-HSA-447115 8.367484e-03 2.077 0 0
Glycolysis R-HSA-70171 1.009461e-02 1.996 0 0
Host Interactions of HIV factors R-HSA-162909 1.014673e-02 1.994 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.024656e-02 1.989 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.029220e-02 1.987 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.068111e-02 1.971 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.081953e-02 1.966 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.088933e-02 1.963 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.111499e-02 1.954 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.111499e-02 1.954 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.116435e-02 1.952 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.116435e-02 1.952 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.116435e-02 1.952 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.116435e-02 1.952 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.121701e-02 1.950 0 0
Metabolism of non-coding RNA R-HSA-194441 1.145034e-02 1.941 0 0
snRNP Assembly R-HSA-191859 1.145034e-02 1.941 0 0
Calmodulin induced events R-HSA-111933 1.164392e-02 1.934 0 0
CaM pathway R-HSA-111997 1.164392e-02 1.934 0 0
FLT3 signaling in disease R-HSA-9682385 1.164392e-02 1.934 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.172418e-02 1.931 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.172418e-02 1.931 0 0
Meiosis R-HSA-1500620 1.200876e-02 1.921 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.210345e-02 1.917 0 0
ALK mutants bind TKIs R-HSA-9700645 1.283290e-02 1.892 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.283290e-02 1.892 0 0
Cellular response to starvation R-HSA-9711097 1.303105e-02 1.885 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.315018e-02 1.881 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.337227e-02 1.874 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.337227e-02 1.874 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.357712e-02 1.867 0 0
MTOR signalling R-HSA-165159 1.369200e-02 1.864 0 0
Ca-dependent events R-HSA-111996 1.369200e-02 1.864 0 0
Signaling by Interleukins R-HSA-449147 1.369836e-02 1.863 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.388921e-02 1.857 0 0
Maturation of protein E R-HSA-9694493 1.388921e-02 1.857 0 0
Maturation of protein E R-HSA-9683683 1.388921e-02 1.857 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.748443e-02 1.757 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.417815e-02 1.848 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.417815e-02 1.848 0 0
Ephrin signaling R-HSA-3928664 1.753535e-02 1.756 0 0
EPH-Ephrin signaling R-HSA-2682334 1.514225e-02 1.820 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.545292e-02 1.811 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.546080e-02 1.811 0 0
Signaling by NOTCH3 R-HSA-9012852 1.504922e-02 1.822 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.565035e-02 1.805 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.545292e-02 1.811 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.629417e-02 1.788 0 0
Developmental Biology R-HSA-1266738 1.502666e-02 1.823 1 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.624514e-02 1.789 0 0
Pexophagy R-HSA-9664873 1.748443e-02 1.757 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.574370e-02 1.803 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.464680e-02 1.834 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.753535e-02 1.756 0 0
RMTs methylate histone arginines R-HSA-3214858 1.795663e-02 1.746 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.804262e-02 1.744 0 0
Signaling by NOTCH1 R-HSA-1980143 1.819076e-02 1.740 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.820170e-02 1.740 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.820170e-02 1.740 0 0
Autophagy R-HSA-9612973 1.856912e-02 1.731 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.953853e-02 1.709 0 0
HIV Life Cycle R-HSA-162587 1.985931e-02 1.702 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.007169e-02 1.697 0 0
CREB phosphorylation R-HSA-199920 2.038206e-02 1.691 0 0
Co-inhibition by PD-1 R-HSA-389948 2.046443e-02 1.689 0 0
Late endosomal microautophagy R-HSA-9615710 2.057448e-02 1.687 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.084050e-02 1.681 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.084050e-02 1.681 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.084050e-02 1.681 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.093826e-02 1.679 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.093826e-02 1.679 0 0
Mitophagy R-HSA-5205647 2.093826e-02 1.679 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.132547e-02 1.671 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.132547e-02 1.671 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.132547e-02 1.671 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.148738e-02 1.668 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.222142e-02 1.653 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.222142e-02 1.653 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.222142e-02 1.653 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.222142e-02 1.653 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.222142e-02 1.653 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.222142e-02 1.653 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.222142e-02 1.653 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.230021e-02 1.652 0 0
Orc1 removal from chromatin R-HSA-68949 2.230021e-02 1.652 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.294378e-02 1.639 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.294378e-02 1.639 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.294378e-02 1.639 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.294378e-02 1.639 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.294378e-02 1.639 0 0
Vesicle-mediated transport R-HSA-5653656 2.301512e-02 1.638 0 0
PECAM1 interactions R-HSA-210990 2.313291e-02 1.636 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.313291e-02 1.636 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.313291e-02 1.636 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.313291e-02 1.636 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.314667e-02 1.636 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.314667e-02 1.636 0 0
Diseases of DNA repair R-HSA-9675135 2.314667e-02 1.636 0 0
Ub-specific processing proteases R-HSA-5689880 2.339044e-02 1.631 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.984303e-02 1.525 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.845164e-02 1.546 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.601775e-02 1.585 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.601775e-02 1.585 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.750164e-02 1.561 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.406075e-02 1.619 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.794794e-02 1.554 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.794794e-02 1.554 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.794794e-02 1.554 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.415827e-02 1.617 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.501659e-02 1.602 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.502982e-02 1.602 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.134946e-02 1.504 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.406075e-02 1.619 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.380173e-02 1.623 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.984303e-02 1.525 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.164105e-02 1.500 0 0
RET signaling R-HSA-8853659 2.772029e-02 1.557 0 0
Regulation of Apoptosis R-HSA-169911 2.415827e-02 1.617 0 0
TGFBR3 expression R-HSA-9839394 2.750164e-02 1.561 0 0
Trafficking of AMPA receptors R-HSA-399719 2.794794e-02 1.554 0 0
Translation R-HSA-72766 2.413250e-02 1.617 0 0
Long-term potentiation R-HSA-9620244 2.750164e-02 1.561 0 0
Degradation of DVL R-HSA-4641258 3.164105e-02 1.500 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.650852e-02 1.577 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.650852e-02 1.577 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.650852e-02 1.577 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.650852e-02 1.577 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.380173e-02 1.623 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.750164e-02 1.561 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.392659e-02 1.621 0 0
Macroautophagy R-HSA-1632852 2.688198e-02 1.571 0 0
Ca2+ pathway R-HSA-4086398 2.597757e-02 1.585 0 0
Basigin interactions R-HSA-210991 3.115945e-02 1.506 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.650852e-02 1.577 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.134946e-02 1.504 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.705813e-02 1.568 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.650852e-02 1.577 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.984303e-02 1.525 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.642422e-02 1.578 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.062391e-02 1.514 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.796935e-02 1.553 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.052561e-02 1.515 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.862558e-02 1.543 0 0
Regulation of gap junction activity R-HSA-191650 3.194305e-02 1.496 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.194305e-02 1.496 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.222377e-02 1.492 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.225621e-02 1.491 0 0
DNA Repair R-HSA-73894 3.280038e-02 1.484 0 0
UCH proteinases R-HSA-5689603 3.432299e-02 1.464 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.451252e-02 1.462 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.462516e-02 1.461 0 0
TNF signaling R-HSA-75893 3.462516e-02 1.461 0 0
Ion homeostasis R-HSA-5578775 3.462516e-02 1.461 0 0
Disorders of Developmental Biology R-HSA-9675151 3.476538e-02 1.459 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.476538e-02 1.459 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.476538e-02 1.459 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.476538e-02 1.459 0 0
Gene Silencing by RNA R-HSA-211000 3.507921e-02 1.455 0 0
Synthesis of DNA R-HSA-69239 3.507921e-02 1.455 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.670679e-02 1.435 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.694133e-02 1.432 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.694133e-02 1.432 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.694133e-02 1.432 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.694133e-02 1.432 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.700404e-02 1.432 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.700404e-02 1.432 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.700404e-02 1.432 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.701409e-02 1.432 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.747054e-02 1.426 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.747054e-02 1.426 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.766406e-02 1.424 0 0
Disorders of Nervous System Development R-HSA-9697154 3.766406e-02 1.424 0 0
Pervasive developmental disorders R-HSA-9005895 3.766406e-02 1.424 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.766406e-02 1.424 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.766406e-02 1.424 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.766406e-02 1.424 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.766406e-02 1.424 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.766406e-02 1.424 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.788932e-02 1.421 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.822053e-02 1.418 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.822053e-02 1.418 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.873659e-02 1.412 0 0
Ion transport by P-type ATPases R-HSA-936837 3.953720e-02 1.403 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.062006e-02 1.391 0 0
Stabilization of p53 R-HSA-69541 4.062006e-02 1.391 0 0
Signaling by ALK R-HSA-201556 4.062006e-02 1.391 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.082679e-02 1.389 0 0
Death Receptor Signaling R-HSA-73887 4.099667e-02 1.387 0 0
HIV Infection R-HSA-162906 4.129484e-02 1.384 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.191727e-02 1.378 0 0
Glycogen storage diseases R-HSA-3229121 4.191727e-02 1.378 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.191727e-02 1.378 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.220810e-02 1.375 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.220810e-02 1.375 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.220810e-02 1.375 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.326170e-02 1.364 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.330776e-02 1.363 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.338778e-02 1.363 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.408895e-02 1.356 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.408895e-02 1.356 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.408895e-02 1.356 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.525931e-02 1.344 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.570569e-02 1.340 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.643821e-02 1.333 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.643821e-02 1.333 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.662930e-02 1.331 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.674091e-02 1.330 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.674091e-02 1.330 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.674091e-02 1.330 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.674091e-02 1.330 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.788303e-02 1.320 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.788303e-02 1.320 0 0
Signaling by TGFBR3 R-HSA-9839373 4.823659e-02 1.317 1 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.828700e-02 1.316 0 0
Glucose metabolism R-HSA-70326 4.910521e-02 1.309 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.961398e-02 1.304 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.965290e-02 1.304 0 0
Unwinding of DNA R-HSA-176974 4.965290e-02 1.304 0 0
GAB1 signalosome R-HSA-180292 4.993137e-02 1.302 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.993137e-02 1.302 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.993137e-02 1.302 0 0
Meiotic synapsis R-HSA-1221632 5.001324e-02 1.301 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.001324e-02 1.301 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.126880e-02 1.290 0 0
Signaling by NOTCH4 R-HSA-9013694 5.226841e-02 1.282 0 0
Signaling by ERBB4 R-HSA-1236394 5.226841e-02 1.282 0 0
RNA Polymerase II Transcription R-HSA-73857 5.248332e-02 1.280 0 0
SARS-CoV Infections R-HSA-9679506 5.349424e-02 1.272 0 0
mRNA Editing: A to I Conversion R-HSA-75064 7.673562e-02 1.115 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.673562e-02 1.115 0 0
C6 deamination of adenosine R-HSA-75102 7.673562e-02 1.115 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.432641e-02 1.192 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.432641e-02 1.192 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.432641e-02 1.192 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.275826e-02 1.202 0 0
Regulation of KIT signaling R-HSA-1433559 5.675615e-02 1.246 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.804659e-02 1.167 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.048790e-02 1.094 0 0
Translesion synthesis by POLI R-HSA-5656121 8.048790e-02 1.094 0 0
Phosphorylation of the APC/C R-HSA-176412 8.048790e-02 1.094 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.834753e-02 1.234 0 0
EGFR downregulation R-HSA-182971 6.405236e-02 1.193 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.069304e-02 1.217 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.151877e-02 1.211 0 0
Dual incision in TC-NER R-HSA-6782135 7.884801e-02 1.103 0 0
Protein ubiquitination R-HSA-8852135 5.672885e-02 1.246 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.191906e-02 1.208 0 0
Glycogen synthesis R-HSA-3322077 6.860034e-02 1.164 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.613392e-02 1.118 0 0
Translesion Synthesis by POLH R-HSA-110320 5.882334e-02 1.230 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.275826e-02 1.202 0 0
Metalloprotease DUBs R-HSA-5689901 7.613392e-02 1.118 0 0
Proteasome assembly R-HSA-9907900 7.750382e-02 1.111 0 0
HDMs demethylate histones R-HSA-3214842 6.688468e-02 1.175 0 0
Regulation of CDH11 function R-HSA-9762292 6.275826e-02 1.202 0 0
Translesion synthesis by REV1 R-HSA-110312 6.804659e-02 1.167 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.344316e-02 1.134 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.613392e-02 1.118 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.882334e-02 1.230 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.712654e-02 1.243 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.688468e-02 1.175 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.853067e-02 1.105 0 0
ER-Phagosome pathway R-HSA-1236974 6.053119e-02 1.218 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.498380e-02 1.260 0 0
Gap junction trafficking and regulation R-HSA-157858 6.525703e-02 1.185 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.804659e-02 1.167 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.404129e-02 1.267 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.712654e-02 1.243 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.882334e-02 1.230 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.712654e-02 1.243 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.712654e-02 1.243 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.853067e-02 1.105 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.673955e-02 1.176 0 0
PCP/CE pathway R-HSA-4086400 7.165107e-02 1.145 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.750382e-02 1.111 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.029622e-02 1.220 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.065805e-02 1.217 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.834753e-02 1.234 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.069304e-02 1.217 0 0
Degradation of AXIN R-HSA-4641257 6.784601e-02 1.168 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.784601e-02 1.168 0 0
Cellular response to hypoxia R-HSA-1234174 7.864082e-02 1.104 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.306209e-02 1.200 0 0
Signaling by FGFR4 R-HSA-5654743 7.027072e-02 1.153 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.804659e-02 1.167 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.673955e-02 1.176 0 0
Semaphorin interactions R-HSA-373755 6.672740e-02 1.176 0 0
Formation of definitive endoderm R-HSA-9823730 6.860034e-02 1.164 0 0
Other interleukin signaling R-HSA-449836 5.882334e-02 1.230 0 0
Oncogene Induced Senescence R-HSA-2559585 5.404129e-02 1.267 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.926123e-02 1.101 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.048790e-02 1.094 0 0
Interleukin-7 signaling R-HSA-1266695 6.688468e-02 1.175 0 0
Negative regulation of FLT3 R-HSA-9706369 8.048790e-02 1.094 0 0
Sensory processing of sound R-HSA-9659379 7.715158e-02 1.113 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.712654e-02 1.243 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.627833e-02 1.179 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.085237e-02 1.092 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.085237e-02 1.092 0 0
PKR-mediated signaling R-HSA-9833482 8.292020e-02 1.081 0 0
Signaling by MET R-HSA-6806834 8.292020e-02 1.081 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.292020e-02 1.081 0 0
HATs acetylate histones R-HSA-3214847 8.348215e-02 1.078 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.413089e-02 1.075 0 0
Neurofascin interactions R-HSA-447043 8.448954e-02 1.073 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.518176e-02 1.070 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.518176e-02 1.070 0 0
Signaling by FGFR3 R-HSA-5654741 8.518176e-02 1.070 0 0
Cilium Assembly R-HSA-5617833 8.572491e-02 1.067 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.609416e-02 1.065 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.609416e-02 1.065 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.051309e-02 1.043 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.079678e-02 1.042 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.330526e-02 1.030 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 9.379581e-02 1.028 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 9.379581e-02 1.028 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.379581e-02 1.028 0 0
Translesion synthesis by POLK R-HSA-5655862 9.405381e-02 1.027 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.405381e-02 1.027 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.405381e-02 1.027 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.675924e-02 1.014 0 0
Dual Incision in GG-NER R-HSA-5696400 1.000246e-01 1.000 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.000246e-01 1.000 0 0
PLC beta mediated events R-HSA-112043 1.003558e-01 0.998 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.003558e-01 0.998 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.015377e-01 0.993 0 0
FLT3 Signaling R-HSA-9607240 1.015377e-01 0.993 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.015377e-01 0.993 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.015377e-01 0.993 0 0
Notch-HLH transcription pathway R-HSA-350054 1.031901e-01 0.986 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.031901e-01 0.986 0 0
Recycling of eIF2:GDP R-HSA-72731 1.069732e-01 0.971 0 0
Disinhibition of SNARE formation R-HSA-114516 1.069732e-01 0.971 0 0
CHL1 interactions R-HSA-447041 1.069732e-01 0.971 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.069732e-01 0.971 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.074270e-01 0.969 0 0
Signaling by Erythropoietin R-HSA-9006335 1.081181e-01 0.966 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.082348e-01 0.966 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.094685e-01 0.961 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.112253e-01 0.954 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.115291e-01 0.953 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.115291e-01 0.953 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.115701e-01 0.952 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.115701e-01 0.952 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.115701e-01 0.952 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.115701e-01 0.952 0 0
Opioid Signalling R-HSA-111885 1.125769e-01 0.949 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.164172e-01 0.934 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.164172e-01 0.934 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.201549e-01 0.920 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.201549e-01 0.920 0 0
Interleukin-1 family signaling R-HSA-446652 1.202765e-01 0.920 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.203278e-01 0.920 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.203278e-01 0.920 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.203278e-01 0.920 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.215242e-01 0.915 0 0
RNA Polymerase III Transcription R-HSA-74158 1.215242e-01 0.915 0 0
Hedgehog 'on' state R-HSA-5632684 1.220823e-01 0.913 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.232258e-01 0.909 0 0
Polo-like kinase mediated events R-HSA-156711 1.243940e-01 0.905 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.243940e-01 0.905 0 0
DNA Replication R-HSA-69306 1.257909e-01 0.900 0 0
G1/S Transition R-HSA-69206 1.258837e-01 0.900 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.301032e-01 0.886 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.304474e-01 0.885 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.304474e-01 0.885 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.307104e-01 0.884 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.307104e-01 0.884 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.307104e-01 0.884 0 0
RSK activation R-HSA-444257 1.314923e-01 0.881 0 0
Signaling by SCF-KIT R-HSA-1433557 1.320759e-01 0.879 0 0
Downstream signal transduction R-HSA-186763 1.328494e-01 0.877 0 0
Signaling by FGFR2 R-HSA-5654738 1.349812e-01 0.870 0 0
Hedgehog 'off' state R-HSA-5610787 1.372828e-01 0.862 0 0
ABC-family proteins mediated transport R-HSA-382556 1.372828e-01 0.862 0 0
Platelet degranulation R-HSA-114608 1.386548e-01 0.858 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.388165e-01 0.858 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.410596e-01 0.851 0 0
The NLRP3 inflammasome R-HSA-844456 1.410596e-01 0.851 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 1.410596e-01 0.851 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.033190e-01 0.692 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.033190e-01 0.692 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.033190e-01 0.692 0 0
Hereditary fructose intolerance R-HSA-5657560 2.033190e-01 0.692 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.033190e-01 0.692 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 2.033190e-01 0.692 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.033190e-01 0.692 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.495042e-01 0.825 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.495042e-01 0.825 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.495042e-01 0.825 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.895766e-01 0.722 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.895766e-01 0.722 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.895766e-01 0.722 0 0
NrCAM interactions R-HSA-447038 1.895766e-01 0.722 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.308581e-01 0.637 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.308581e-01 0.637 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.854404e-01 0.732 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.854404e-01 0.732 0 0
2-LTR circle formation R-HSA-164843 1.854404e-01 0.732 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.726270e-01 0.564 0 0
Signaling by LTK in cancer R-HSA-9842640 2.726270e-01 0.564 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.726270e-01 0.564 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.725940e-01 0.763 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.950688e-01 0.710 0 0
Activation of RAC1 R-HSA-428540 2.439687e-01 0.613 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 2.439687e-01 0.613 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.439687e-01 0.613 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.439687e-01 0.613 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.770482e-01 0.752 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.183792e-01 0.661 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.607652e-01 0.794 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.742585e-01 0.562 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.742585e-01 0.562 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.742585e-01 0.562 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.742585e-01 0.562 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.742585e-01 0.562 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.742585e-01 0.562 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.742585e-01 0.562 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.769646e-01 0.752 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.769646e-01 0.752 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.423839e-01 0.615 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.423839e-01 0.615 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.937917e-01 0.713 0 0
HIV elongation arrest and recovery R-HSA-167287 1.937917e-01 0.713 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.937917e-01 0.713 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.746181e-01 0.758 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.669435e-01 0.574 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.365032e-01 0.626 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.668614e-01 0.778 0 0
DAP12 signaling R-HSA-2424491 2.291126e-01 0.640 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.291126e-01 0.640 0 0
Deadenylation of mRNA R-HSA-429947 2.574458e-01 0.589 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.627520e-01 0.788 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.835292e-01 0.736 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.473040e-01 0.607 0 0
G-protein beta:gamma signalling R-HSA-397795 2.853983e-01 0.545 0 0
G0 and Early G1 R-HSA-1538133 1.461774e-01 0.835 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.434123e-01 0.614 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.896650e-01 0.722 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.291126e-01 0.640 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.452535e-01 0.838 0 0
Elastic fibre formation R-HSA-1566948 2.544764e-01 0.594 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.895766e-01 0.722 0 0
Developmental Cell Lineages R-HSA-9734767 2.700916e-01 0.568 0 0
Integration of provirus R-HSA-162592 2.439687e-01 0.613 0 0
Protein folding R-HSA-391251 1.917058e-01 0.717 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.854404e-01 0.732 0 0
Formation of the posterior neural plate R-HSA-9832991 2.142744e-01 0.669 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.725940e-01 0.763 0 0
Cyclin D associated events in G1 R-HSA-69231 1.432172e-01 0.844 0 0
G1 Phase R-HSA-69236 1.432172e-01 0.844 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.666716e-01 0.778 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 1.895766e-01 0.722 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.510954e-01 0.821 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 2.726270e-01 0.564 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 2.726270e-01 0.564 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.439687e-01 0.613 0 0
Nuclear RNA decay R-HSA-9930044 2.853983e-01 0.545 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.716276e-01 0.566 0 0
Myogenesis R-HSA-525793 1.607652e-01 0.794 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.474928e-01 0.606 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.183792e-01 0.661 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.742585e-01 0.562 0 0
Regulation of IFNG signaling R-HSA-877312 2.742585e-01 0.562 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.746181e-01 0.758 0 0
Prolonged ERK activation events R-HSA-169893 1.950688e-01 0.710 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.792390e-01 0.747 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.892778e-01 0.723 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 2.742585e-01 0.562 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.574458e-01 0.589 0 0
Glycogen metabolism R-HSA-8982491 1.710670e-01 0.767 0 0
Meiotic recombination R-HSA-912446 2.330365e-01 0.633 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.033190e-01 0.692 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.895766e-01 0.722 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.854404e-01 0.732 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.669435e-01 0.574 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.781296e-01 0.749 0 0
Gap junction trafficking R-HSA-190828 1.432172e-01 0.844 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.793301e-01 0.746 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.121838e-01 0.673 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.515628e-01 0.599 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.163697e-01 0.665 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.607652e-01 0.794 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.607652e-01 0.794 0 0
Apoptotic factor-mediated response R-HSA-111471 2.669435e-01 0.574 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.510954e-01 0.821 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.160656e-01 0.665 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.853594e-01 0.732 0 0
Signaling by NOTCH2 R-HSA-1980145 1.896650e-01 0.722 0 0
Co-stimulation by CD28 R-HSA-389356 1.922041e-01 0.716 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.586356e-01 0.800 0 0
ERK/MAPK targets R-HSA-198753 1.770482e-01 0.752 0 0
Circadian clock R-HSA-9909396 1.812351e-01 0.742 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.111930e-01 0.675 0 0
Platelet sensitization by LDL R-HSA-432142 2.669435e-01 0.574 0 0
G-protein mediated events R-HSA-112040 1.528316e-01 0.816 0 0
Formation of the anterior neural plate R-HSA-9823739 1.725940e-01 0.763 0 0
Neurexins and neuroligins R-HSA-6794361 2.473040e-01 0.607 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.128110e-01 0.672 0 0
Signaling by PDGF R-HSA-186797 2.775318e-01 0.557 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.566490e-01 0.805 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.033190e-01 0.692 0 0
Inhibition of PKR R-HSA-169131 2.033190e-01 0.692 0 0
Protein hydroxylation R-HSA-9629569 1.586356e-01 0.800 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.950688e-01 0.710 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.423839e-01 0.615 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.111930e-01 0.675 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 2.574458e-01 0.589 0 0
Kinesins R-HSA-983189 1.575964e-01 0.802 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.048043e-01 0.689 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.770482e-01 0.752 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.853983e-01 0.545 0 0
Transmission across Chemical Synapses R-HSA-112315 2.784761e-01 0.555 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.510954e-01 0.821 0 0
TCR signaling R-HSA-202403 1.624559e-01 0.789 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.574458e-01 0.589 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.473040e-01 0.607 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.142744e-01 0.669 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.937917e-01 0.713 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.111930e-01 0.675 0 0
Gastrulation R-HSA-9758941 2.043419e-01 0.690 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.474928e-01 0.606 0 0
Signaling by NTRKs R-HSA-166520 1.967377e-01 0.706 0 0
Signaling by FGFR in disease R-HSA-1226099 2.285213e-01 0.641 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.710670e-01 0.767 0 0
Generic Transcription Pathway R-HSA-212436 1.980420e-01 0.703 0 0
MAP kinase activation R-HSA-450294 2.635994e-01 0.579 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.542449e-01 0.812 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.308581e-01 0.637 0 0
Signal regulatory protein family interactions R-HSA-391160 1.510954e-01 0.821 0 0
Nef and signal transduction R-HSA-164944 2.726270e-01 0.564 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.601108e-01 0.796 0 0
DNA strand elongation R-HSA-69190 2.662745e-01 0.575 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.853983e-01 0.545 0 0
Signaling by FGFR1 R-HSA-5654736 1.978749e-01 0.704 0 0
Regulation of beta-cell development R-HSA-186712 2.364583e-01 0.626 0 0
Signaling by Hedgehog R-HSA-5358351 1.743448e-01 0.759 0 0
Reproduction R-HSA-1474165 1.663482e-01 0.779 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.495042e-01 0.825 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.577483e-01 0.802 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.308581e-01 0.637 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.854404e-01 0.732 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.726270e-01 0.564 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.512052e-01 0.820 0 0
Defective pyroptosis R-HSA-9710421 2.281658e-01 0.642 0 0
Assembly Of The HIV Virion R-HSA-175474 1.962190e-01 0.707 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.420576e-01 0.616 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.788074e-01 0.555 0 0
Formation of apoptosome R-HSA-111458 1.854404e-01 0.732 0 0
Diseases of programmed cell death R-HSA-9645723 2.203251e-01 0.657 0 0
Cardiogenesis R-HSA-9733709 2.853983e-01 0.545 0 0
Insulin processing R-HSA-264876 1.769646e-01 0.752 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.491065e-01 0.827 0 0
Viral Infection Pathways R-HSA-9824446 2.588146e-01 0.587 0 0
tRNA processing in the nucleus R-HSA-6784531 1.792390e-01 0.747 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.104251e-01 0.677 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.716276e-01 0.566 0 0
Neurodegenerative Diseases R-HSA-8863678 2.574458e-01 0.589 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.574458e-01 0.589 0 0
Syndecan interactions R-HSA-3000170 2.365032e-01 0.626 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.510954e-01 0.821 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.769646e-01 0.752 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.962190e-01 0.707 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.769646e-01 0.752 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.548177e-01 0.810 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.183792e-01 0.661 0 0
Interferon alpha/beta signaling R-HSA-909733 1.564706e-01 0.806 0 0
Potential therapeutics for SARS R-HSA-9679191 2.809571e-01 0.551 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.111930e-01 0.675 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.548177e-01 0.810 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.548177e-01 0.810 0 0
FOXO-mediated transcription R-HSA-9614085 2.745429e-01 0.561 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.816846e-01 0.741 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.473040e-01 0.607 0 0
IRE1alpha activates chaperones R-HSA-381070 2.642804e-01 0.578 0 0
Regulation of BACH1 activity R-HSA-9708530 1.950688e-01 0.710 0 0
Selenoamino acid metabolism R-HSA-2408522 2.594347e-01 0.586 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.888314e-01 0.539 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.889141e-01 0.539 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.889141e-01 0.539 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.889141e-01 0.539 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.889141e-01 0.539 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.889141e-01 0.539 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.889141e-01 0.539 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.889141e-01 0.539 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.889141e-01 0.539 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.890712e-01 0.539 0 0
HIV Transcription Elongation R-HSA-167169 2.890712e-01 0.539 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.890712e-01 0.539 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.890712e-01 0.539 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.890712e-01 0.539 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.909684e-01 0.536 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.916755e-01 0.535 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.919218e-01 0.535 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 2.919218e-01 0.535 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 2.919218e-01 0.535 0 0
Specification of the neural plate border R-HSA-9834899 2.919218e-01 0.535 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.005025e-01 0.522 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.048047e-01 0.516 0 0
Formation of axial mesoderm R-HSA-9796292 3.048987e-01 0.516 0 0
Frs2-mediated activation R-HSA-170968 3.048987e-01 0.516 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.048987e-01 0.516 0 0
GPER1 signaling R-HSA-9634597 3.073124e-01 0.512 0 0
Gluconeogenesis R-HSA-70263 3.073124e-01 0.512 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.143024e-01 0.503 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.143024e-01 0.503 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.143024e-01 0.503 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.143024e-01 0.503 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.143024e-01 0.503 0 0
SOS-mediated signalling R-HSA-112412 3.143024e-01 0.503 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.143024e-01 0.503 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.143024e-01 0.503 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.143024e-01 0.503 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.143024e-01 0.503 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.143024e-01 0.503 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.143024e-01 0.503 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.171883e-01 0.499 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.224477e-01 0.492 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.224477e-01 0.492 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.224477e-01 0.492 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.224477e-01 0.492 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.244348e-01 0.489 0 0
Translation of Structural Proteins R-HSA-9683701 3.246587e-01 0.489 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.282038e-01 0.484 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.426184e-01 0.465 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.426184e-01 0.465 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.426184e-01 0.465 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.426184e-01 0.465 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.426184e-01 0.465 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.427144e-01 0.465 0 0
Signalling to ERKs R-HSA-187687 3.442304e-01 0.463 0 0
PERK regulates gene expression R-HSA-381042 3.442304e-01 0.463 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.445618e-01 0.463 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.445618e-01 0.463 0 0
Inflammasomes R-HSA-622312 3.445618e-01 0.463 0 0
Iron uptake and transport R-HSA-917937 3.461579e-01 0.461 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.507891e-01 0.455 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.551573e-01 0.450 0 0
Type I hemidesmosome assembly R-HSA-446107 3.554226e-01 0.449 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.554226e-01 0.449 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.554226e-01 0.449 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.554226e-01 0.449 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.554226e-01 0.449 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.554226e-01 0.449 0 0
Adrenoceptors R-HSA-390696 3.554226e-01 0.449 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.554226e-01 0.449 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.554226e-01 0.449 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.554226e-01 0.449 0 0
Co-stimulation by ICOS R-HSA-9927354 3.554226e-01 0.449 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.554226e-01 0.449 0 0
Signaling by FGFR R-HSA-190236 3.596815e-01 0.444 0 0
TBC/RABGAPs R-HSA-8854214 3.608869e-01 0.443 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.641350e-01 0.439 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.653173e-01 0.437 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.653173e-01 0.437 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.653173e-01 0.437 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.653173e-01 0.437 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.653173e-01 0.437 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.653173e-01 0.437 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.653173e-01 0.437 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.653173e-01 0.437 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.653173e-01 0.437 0 0
Glycogen storage disease type 0 (liver GYS2) R-HSA-3858516 3.653173e-01 0.437 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.653173e-01 0.437 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.653173e-01 0.437 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.653173e-01 0.437 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.653173e-01 0.437 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.653173e-01 0.437 0 0
Signalling to ERK5 R-HSA-198765 3.653173e-01 0.437 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.653173e-01 0.437 0 0
Antagonism of Activin by Follistatin R-HSA-2473224 3.653173e-01 0.437 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.653173e-01 0.437 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.653173e-01 0.437 0 0
Erythropoietin activates RAS R-HSA-9027284 3.663589e-01 0.436 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.663589e-01 0.436 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.663589e-01 0.436 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.663589e-01 0.436 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 3.663589e-01 0.436 0 0
DCC mediated attractive signaling R-HSA-418885 3.663589e-01 0.436 0 0
Biotin transport and metabolism R-HSA-196780 3.663589e-01 0.436 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.667664e-01 0.436 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.667664e-01 0.436 0 0
DARPP-32 events R-HSA-180024 3.667664e-01 0.436 0 0
Platelet calcium homeostasis R-HSA-418360 3.667664e-01 0.436 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.680952e-01 0.434 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.680952e-01 0.434 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.680952e-01 0.434 0 0
Chromosome Maintenance R-HSA-73886 3.687661e-01 0.433 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.692611e-01 0.433 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.721644e-01 0.429 0 0
Integration of energy metabolism R-HSA-163685 3.803512e-01 0.420 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.852777e-01 0.414 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.852777e-01 0.414 0 0
Integrin cell surface interactions R-HSA-216083 3.885505e-01 0.411 0 0
G alpha (12/13) signalling events R-HSA-416482 3.885505e-01 0.411 0 0
ABC transporter disorders R-HSA-5619084 3.885505e-01 0.411 0 0
Activation of the pre-replicative complex R-HSA-68962 3.889871e-01 0.410 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.889871e-01 0.410 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.889871e-01 0.410 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.889871e-01 0.410 0 0
FGFR2 alternative splicing R-HSA-6803529 3.935098e-01 0.405 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.935098e-01 0.405 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.935098e-01 0.405 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 3.935098e-01 0.405 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.935098e-01 0.405 0 0
Interleukin-17 signaling R-HSA-448424 3.946600e-01 0.404 0 0
ARMS-mediated activation R-HSA-170984 3.956261e-01 0.403 0 0
Lipophagy R-HSA-9613354 3.956261e-01 0.403 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.956261e-01 0.403 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.956261e-01 0.403 0 0
mRNA Editing R-HSA-75072 3.956261e-01 0.403 0 0
Calcineurin activates NFAT R-HSA-2025928 3.956261e-01 0.403 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.956261e-01 0.403 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.956261e-01 0.403 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.956261e-01 0.403 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.956261e-01 0.403 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.956261e-01 0.403 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.967990e-01 0.401 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.967990e-01 0.401 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.967990e-01 0.401 0 0
Activation of SMO R-HSA-5635838 3.967990e-01 0.401 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.967990e-01 0.401 0 0
Nucleosome assembly R-HSA-774815 3.974137e-01 0.401 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.974137e-01 0.401 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.974137e-01 0.401 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.974137e-01 0.401 0 0
Somitogenesis R-HSA-9824272 3.974137e-01 0.401 0 0
Heme signaling R-HSA-9707616 4.011631e-01 0.397 0 0
HCMV Early Events R-HSA-9609690 4.018100e-01 0.396 0 0
Cardiac conduction R-HSA-5576891 4.075229e-01 0.390 0 0
Molecules associated with elastic fibres R-HSA-2129379 4.111531e-01 0.386 0 0
Budding and maturation of HIV virion R-HSA-162588 4.111531e-01 0.386 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.151494e-01 0.382 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.151494e-01 0.382 0 0
Ion channel transport R-HSA-983712 4.164429e-01 0.380 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.170599e-01 0.380 0 0
Signaling by PTK6 R-HSA-8848021 4.170599e-01 0.380 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.170599e-01 0.380 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.187615e-01 0.378 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.187615e-01 0.378 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.187615e-01 0.378 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.187615e-01 0.378 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.239647e-01 0.373 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.239647e-01 0.373 0 0
G alpha (z) signalling events R-HSA-418597 4.250895e-01 0.372 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.268293e-01 0.370 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.268293e-01 0.370 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.329423e-01 0.364 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.331982e-01 0.363 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.331982e-01 0.363 0 0
PLC-gamma1 signalling R-HSA-167021 4.335154e-01 0.363 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.335154e-01 0.363 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.335154e-01 0.363 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.335154e-01 0.363 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 4.335154e-01 0.363 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.335154e-01 0.363 0 0
MET activates PTPN11 R-HSA-8865999 4.335154e-01 0.363 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.335154e-01 0.363 0 0
MET interacts with TNS proteins R-HSA-8875513 4.335154e-01 0.363 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.335154e-01 0.363 0 0
NGF processing R-HSA-167060 4.335154e-01 0.363 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.335154e-01 0.363 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.339152e-01 0.363 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.346352e-01 0.362 0 0
PI3K/AKT activation R-HSA-198203 4.346352e-01 0.362 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.346352e-01 0.362 0 0
Maturation of spike protein R-HSA-9683686 4.346352e-01 0.362 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.346352e-01 0.362 0 0
Inositol phosphate metabolism R-HSA-1483249 4.393276e-01 0.357 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.436935e-01 0.353 0 0
Downstream TCR signaling R-HSA-202424 4.507248e-01 0.346 0 0
Interferon gamma signaling R-HSA-877300 4.511678e-01 0.346 0 0
Intraflagellar transport R-HSA-5620924 4.520615e-01 0.345 0 0
Integrin signaling R-HSA-354192 4.550606e-01 0.342 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.563144e-01 0.341 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.563144e-01 0.341 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.582314e-01 0.339 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.634498e-01 0.334 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.634498e-01 0.334 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.683691e-01 0.329 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.683691e-01 0.329 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.683691e-01 0.329 0 0
DNA Damage Bypass R-HSA-73893 4.700911e-01 0.328 0 0
Signaling by APC mutants R-HSA-4839744 4.722427e-01 0.326 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.722427e-01 0.326 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.722427e-01 0.326 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.722427e-01 0.326 0 0
Bicarbonate transporters R-HSA-425381 4.722427e-01 0.326 0 0
vRNP Assembly R-HSA-192905 4.722427e-01 0.326 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.722427e-01 0.326 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.766831e-01 0.322 0 0
Intra-Golgi traffic R-HSA-6811438 4.829365e-01 0.316 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.851387e-01 0.314 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.851387e-01 0.314 0 0
Nephron development R-HSA-9831926 4.851387e-01 0.314 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.851387e-01 0.314 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.851387e-01 0.314 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.879710e-01 0.312 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.893436e-01 0.310 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.921947e-01 0.308 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.926677e-01 0.307 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.926677e-01 0.307 0 0
Hemostasis R-HSA-109582 4.928434e-01 0.307 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.943890e-01 0.306 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.943890e-01 0.306 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.943890e-01 0.306 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.943890e-01 0.306 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.943890e-01 0.306 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.943890e-01 0.306 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.943890e-01 0.306 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.943890e-01 0.306 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.943890e-01 0.306 0 0
NADE modulates death signalling R-HSA-205025 4.943890e-01 0.306 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.943890e-01 0.306 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.980136e-01 0.303 0 0
Signal amplification R-HSA-392518 4.980136e-01 0.303 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.021991e-01 0.299 0 0
Interleukin-1 signaling R-HSA-9020702 5.069950e-01 0.295 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.082994e-01 0.294 0 0
Signaling by AXIN mutants R-HSA-4839735 5.082994e-01 0.294 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.082994e-01 0.294 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.082994e-01 0.294 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.082994e-01 0.294 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.082994e-01 0.294 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.132057e-01 0.290 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.132057e-01 0.290 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.132057e-01 0.290 0 0
Rap1 signalling R-HSA-392517 5.132057e-01 0.290 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.164398e-01 0.287 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.164398e-01 0.287 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.212012e-01 0.283 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.259508e-01 0.279 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.348639e-01 0.272 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.396784e-01 0.268 0 0
DAP12 interactions R-HSA-2172127 5.399095e-01 0.268 0 0
Netrin-1 signaling R-HSA-373752 5.399095e-01 0.268 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.404361e-01 0.267 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.404361e-01 0.267 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.404361e-01 0.267 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.404361e-01 0.267 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.417405e-01 0.266 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.427044e-01 0.265 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.427044e-01 0.265 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.427044e-01 0.265 0 0
OAS antiviral response R-HSA-8983711 5.427044e-01 0.265 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.465066e-01 0.262 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.465066e-01 0.262 0 0
IRS activation R-HSA-74713 5.487243e-01 0.261 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.487243e-01 0.261 0 0
Defective F9 activation R-HSA-9673221 5.487243e-01 0.261 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.487243e-01 0.261 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.487243e-01 0.261 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.487243e-01 0.261 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.487243e-01 0.261 0 0
Activation of AKT2 R-HSA-165158 5.487243e-01 0.261 0 0
Co-inhibition by BTLA R-HSA-9927353 5.487243e-01 0.261 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.487243e-01 0.261 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.487243e-01 0.261 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.566914e-01 0.254 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.572893e-01 0.254 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.572893e-01 0.254 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.576468e-01 0.254 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.582937e-01 0.253 0 0
DNA methylation R-HSA-5334118 5.623346e-01 0.250 0 0
mRNA Capping R-HSA-72086 5.623346e-01 0.250 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.623346e-01 0.250 0 0
G-protein activation R-HSA-202040 5.667666e-01 0.247 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.667666e-01 0.247 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.694920e-01 0.245 0 0
Cellular response to chemical stress R-HSA-9711123 5.751645e-01 0.240 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.753962e-01 0.240 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.753962e-01 0.240 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.753962e-01 0.240 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.753962e-01 0.240 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.753962e-01 0.240 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.753962e-01 0.240 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.763265e-01 0.239 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.763265e-01 0.239 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.763265e-01 0.239 0 0
MET promotes cell motility R-HSA-8875878 5.795361e-01 0.237 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.803235e-01 0.236 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.808186e-01 0.236 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.808186e-01 0.236 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.824097e-01 0.235 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.833055e-01 0.234 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.843672e-01 0.233 0 0
NRAGE signals death through JNK R-HSA-193648 5.905121e-01 0.229 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.927870e-01 0.227 0 0
Phosphorylation of Emi1 R-HSA-176417 5.972234e-01 0.224 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.972234e-01 0.224 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.972234e-01 0.224 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.972234e-01 0.224 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.972234e-01 0.224 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.972234e-01 0.224 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.972234e-01 0.224 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.972234e-01 0.224 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.972234e-01 0.224 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.972234e-01 0.224 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.972234e-01 0.224 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.972234e-01 0.224 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.972234e-01 0.224 0 0
PDE3B signalling R-HSA-165160 5.972234e-01 0.224 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.972234e-01 0.224 0 0
PKB-mediated events R-HSA-109703 5.972234e-01 0.224 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.972234e-01 0.224 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.972234e-01 0.224 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.972234e-01 0.224 0 0
Relaxin receptors R-HSA-444821 5.972234e-01 0.224 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.972234e-01 0.224 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.972234e-01 0.224 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.972234e-01 0.224 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.987885e-01 0.223 0 0
RAS processing R-HSA-9648002 5.987885e-01 0.223 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.987885e-01 0.223 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.055780e-01 0.218 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.063458e-01 0.217 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.063458e-01 0.217 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.063458e-01 0.217 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.086202e-01 0.216 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.107330e-01 0.214 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.134997e-01 0.212 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.165464e-01 0.210 0 0
Signaling by KIT in disease R-HSA-9669938 6.165464e-01 0.210 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.172681e-01 0.210 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.175338e-01 0.209 0 0
Generation of second messenger molecules R-HSA-202433 6.175338e-01 0.209 0 0
Interleukin-2 family signaling R-HSA-451927 6.175338e-01 0.209 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.196120e-01 0.208 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.223303e-01 0.206 0 0
Signaling by WNT in cancer R-HSA-4791275 6.264326e-01 0.203 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.281181e-01 0.202 0 0
Regulated Necrosis R-HSA-5218859 6.323917e-01 0.199 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.355500e-01 0.197 0 0
p38MAPK events R-HSA-171007 6.355500e-01 0.197 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.355500e-01 0.197 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.355500e-01 0.197 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.355500e-01 0.197 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.357516e-01 0.197 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.399359e-01 0.194 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.405128e-01 0.193 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.405128e-01 0.193 0 0
STAT5 Activation R-HSA-9645135 6.405128e-01 0.193 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.405128e-01 0.193 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.405128e-01 0.193 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.405128e-01 0.193 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.405128e-01 0.193 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.405128e-01 0.193 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.405128e-01 0.193 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.405128e-01 0.193 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.405128e-01 0.193 0 0
Lactose synthesis R-HSA-5653890 6.405128e-01 0.193 0 0
Abacavir transmembrane transport R-HSA-2161517 6.405128e-01 0.193 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.405128e-01 0.193 0 0
VLDL assembly R-HSA-8866423 6.405128e-01 0.193 0 0
Leukotriene receptors R-HSA-391906 6.405128e-01 0.193 0 0
Neutrophil degranulation R-HSA-6798695 6.443551e-01 0.191 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.464172e-01 0.189 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.527338e-01 0.185 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.534251e-01 0.185 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.549000e-01 0.184 0 0
Protein localization R-HSA-9609507 6.591968e-01 0.181 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.623036e-01 0.179 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.623036e-01 0.179 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.630265e-01 0.178 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.630265e-01 0.178 0 0
Atorvastatin ADME R-HSA-9754706 6.630265e-01 0.178 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.656811e-01 0.177 0 0
Aquaporin-mediated transport R-HSA-445717 6.673748e-01 0.176 0 0
Toll-like Receptor Cascades R-HSA-168898 6.777407e-01 0.169 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.791518e-01 0.168 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.791518e-01 0.168 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.791518e-01 0.168 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.791518e-01 0.168 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.791518e-01 0.168 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.791518e-01 0.168 0 0
LDL remodeling R-HSA-8964041 6.791518e-01 0.168 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.791518e-01 0.168 0 0
Netrin mediated repulsion signals R-HSA-418886 6.791518e-01 0.168 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.791518e-01 0.168 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.791518e-01 0.168 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.791518e-01 0.168 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.836447e-01 0.165 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.836447e-01 0.165 0 0
G protein gated Potassium channels R-HSA-1296059 6.836447e-01 0.165 0 0
Tight junction interactions R-HSA-420029 6.836447e-01 0.165 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.836447e-01 0.165 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.836447e-01 0.165 0 0
Gap junction assembly R-HSA-190861 6.842144e-01 0.165 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.842144e-01 0.165 0 0
Platelet homeostasis R-HSA-418346 6.879199e-01 0.162 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.887422e-01 0.162 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.888092e-01 0.162 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.888092e-01 0.162 0 0
Fibronectin matrix formation R-HSA-1566977 6.888092e-01 0.162 0 0
Heme assimilation R-HSA-9927020 6.888092e-01 0.162 0 0
Passive transport by Aquaporins R-HSA-432047 6.888092e-01 0.162 0 0
Synthesis of PG R-HSA-1483148 6.888092e-01 0.162 0 0
MHC class II antigen presentation R-HSA-2132295 6.899907e-01 0.161 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.919936e-01 0.160 0 0
Regulation of insulin secretion R-HSA-422356 6.928020e-01 0.159 0 0
Adipogenesis R-HSA-9843745 6.960641e-01 0.157 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.020121e-01 0.154 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.020121e-01 0.154 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.039625e-01 0.152 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.049935e-01 0.152 0 0
Neuronal System R-HSA-112316 7.053265e-01 0.152 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.129448e-01 0.147 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.129448e-01 0.147 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.129448e-01 0.147 0 0
Specification of primordial germ cells R-HSA-9827857 7.129448e-01 0.147 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.129448e-01 0.147 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.136398e-01 0.147 0 0
phospho-PLA2 pathway R-HSA-111995 7.136398e-01 0.147 0 0
MET receptor recycling R-HSA-8875656 7.136398e-01 0.147 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.136398e-01 0.147 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.136398e-01 0.147 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.136398e-01 0.147 0 0
Activation of RAS in B cells R-HSA-1169092 7.136398e-01 0.147 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.136398e-01 0.147 0 0
Sodium/Proton exchangers R-HSA-425986 7.136398e-01 0.147 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.136398e-01 0.147 0 0
Interleukin-23 signaling R-HSA-9020933 7.136398e-01 0.147 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.184667e-01 0.144 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.197171e-01 0.143 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.232669e-01 0.141 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.232669e-01 0.141 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.332887e-01 0.135 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.332971e-01 0.135 0 0
PKA activation R-HSA-163615 7.354893e-01 0.133 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.354893e-01 0.133 0 0
PKA activation in glucagon signalling R-HSA-164378 7.354893e-01 0.133 0 0
Mismatch Repair R-HSA-5358508 7.354893e-01 0.133 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.354893e-01 0.133 0 0
Tie2 Signaling R-HSA-210993 7.354893e-01 0.133 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.354893e-01 0.133 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.415735e-01 0.130 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.415735e-01 0.130 0 0
WNT mediated activation of DVL R-HSA-201688 7.444225e-01 0.128 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.444225e-01 0.128 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.444225e-01 0.128 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.444225e-01 0.128 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.444225e-01 0.128 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.444225e-01 0.128 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.444225e-01 0.128 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.444225e-01 0.128 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.444225e-01 0.128 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.444225e-01 0.128 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.444225e-01 0.128 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.444225e-01 0.128 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.444225e-01 0.128 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.444225e-01 0.128 0 0
IRS-mediated signalling R-HSA-112399 7.464987e-01 0.127 0 0
Synthesis of PA R-HSA-1483166 7.464987e-01 0.127 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.469158e-01 0.127 0 0
Translation of Structural Proteins R-HSA-9694635 7.482498e-01 0.126 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.565060e-01 0.121 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.565060e-01 0.121 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.586628e-01 0.120 0 0
Transcription of the HIV genome R-HSA-167172 7.587575e-01 0.120 0 0
Glucagon-type ligand receptors R-HSA-420092 7.589030e-01 0.120 0 0
Immune System R-HSA-168256 7.679061e-01 0.115 0 0
Peroxisomal protein import R-HSA-9033241 7.713809e-01 0.113 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.713809e-01 0.113 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.718977e-01 0.112 0 0
Binding and entry of HIV virion R-HSA-173107 7.718977e-01 0.112 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.718977e-01 0.112 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.718977e-01 0.112 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.718977e-01 0.112 0 0
Signal attenuation R-HSA-74749 7.718977e-01 0.112 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.718977e-01 0.112 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.718977e-01 0.112 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.718977e-01 0.112 0 0
Interleukin-27 signaling R-HSA-9020956 7.718977e-01 0.112 0 0
Signaling by Leptin R-HSA-2586552 7.718977e-01 0.112 0 0
HCMV Infection R-HSA-9609646 7.732406e-01 0.112 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.752797e-01 0.111 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.758029e-01 0.110 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.760626e-01 0.110 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.760626e-01 0.110 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.760626e-01 0.110 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.779590e-01 0.109 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.800689e-01 0.108 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.800689e-01 0.108 0 0
Diseases of Immune System R-HSA-5260271 7.800689e-01 0.108 0 0
COPII-mediated vesicle transport R-HSA-204005 7.812287e-01 0.107 0 0
Telomere Maintenance R-HSA-157579 7.815815e-01 0.107 0 0
PI3K Cascade R-HSA-109704 7.868655e-01 0.104 0 0
Neurotransmitter release cycle R-HSA-112310 7.903461e-01 0.102 0 0
Amyloid fiber formation R-HSA-977225 7.906469e-01 0.102 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.907314e-01 0.102 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.942302e-01 0.100 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.942302e-01 0.100 0 0
Signalling to RAS R-HSA-167044 7.942302e-01 0.100 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.942302e-01 0.100 0 0
Lagging Strand Synthesis R-HSA-69186 7.942302e-01 0.100 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.943918e-01 0.100 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.964207e-01 0.099 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.964207e-01 0.099 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.964207e-01 0.099 0 0
vRNA Synthesis R-HSA-192814 7.964207e-01 0.099 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.964207e-01 0.099 0 0
Chylomicron assembly R-HSA-8963888 7.964207e-01 0.099 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.964207e-01 0.099 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.964207e-01 0.099 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.964207e-01 0.099 0 0
LGI-ADAM interactions R-HSA-5682910 7.964207e-01 0.099 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.964207e-01 0.099 0 0
Prostanoid ligand receptors R-HSA-391908 7.964207e-01 0.099 0 0
Interleukin-2 signaling R-HSA-9020558 7.964207e-01 0.099 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.964207e-01 0.099 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.052884e-01 0.094 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.063759e-01 0.093 0 0
HIV Transcription Initiation R-HSA-167161 8.063759e-01 0.093 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.063759e-01 0.093 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.063759e-01 0.093 0 0
Rab regulation of trafficking R-HSA-9007101 8.087479e-01 0.092 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.097506e-01 0.092 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.108163e-01 0.091 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.110813e-01 0.091 0 0
Attachment and Entry R-HSA-9694614 8.110813e-01 0.091 0 0
Serine metabolism R-HSA-977347 8.110813e-01 0.091 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.110813e-01 0.091 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.119559e-01 0.090 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.172064e-01 0.088 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.183086e-01 0.087 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.183086e-01 0.087 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.183086e-01 0.087 0 0
ERKs are inactivated R-HSA-202670 8.183086e-01 0.087 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.183086e-01 0.087 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.183086e-01 0.087 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.185370e-01 0.087 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.189828e-01 0.087 0 0
IGF1R signaling cascade R-HSA-2428924 8.255096e-01 0.083 0 0
Insulin receptor signalling cascade R-HSA-74751 8.255096e-01 0.083 0 0
Neddylation R-HSA-8951664 8.260332e-01 0.083 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.266890e-01 0.083 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.279144e-01 0.082 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.300619e-01 0.081 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.318483e-01 0.080 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.336050e-01 0.079 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.350089e-01 0.078 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.358738e-01 0.078 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.378444e-01 0.077 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.378444e-01 0.077 0 0
Leading Strand Synthesis R-HSA-69109 8.378444e-01 0.077 0 0
Polymerase switching R-HSA-69091 8.378444e-01 0.077 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.378444e-01 0.077 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.378444e-01 0.077 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.378444e-01 0.077 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.378444e-01 0.077 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.378444e-01 0.077 0 0
MET activates RAS signaling R-HSA-8851805 8.378444e-01 0.077 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.378444e-01 0.077 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.378444e-01 0.077 0 0
Interleukin-15 signaling R-HSA-8983432 8.378444e-01 0.077 0 0
Signaling by LTK R-HSA-9842663 8.378444e-01 0.077 0 0
Interleukin-35 Signalling R-HSA-8984722 8.378444e-01 0.077 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.411257e-01 0.075 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.411257e-01 0.075 0 0
Growth hormone receptor signaling R-HSA-982772 8.411257e-01 0.075 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.411257e-01 0.075 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.413646e-01 0.075 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.439195e-01 0.074 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.439195e-01 0.074 0 0
Adaptive Immune System R-HSA-1280218 8.441306e-01 0.074 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.512850e-01 0.070 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.544628e-01 0.068 0 0
Complex III assembly R-HSA-9865881 8.544628e-01 0.068 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.544628e-01 0.068 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.544628e-01 0.068 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.552806e-01 0.068 0 0
Processing of SMDT1 R-HSA-8949664 8.552806e-01 0.068 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.552806e-01 0.068 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.552806e-01 0.068 0 0
Maturation of nucleoprotein R-HSA-9683610 8.552806e-01 0.068 0 0
Interleukin-6 signaling R-HSA-1059683 8.552806e-01 0.068 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.563881e-01 0.067 0 0
tRNA processing R-HSA-72306 8.619887e-01 0.064 0 0
GPVI-mediated activation cascade R-HSA-114604 8.658198e-01 0.063 0 0
RUNX2 regulates bone development R-HSA-8941326 8.658198e-01 0.063 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.658198e-01 0.063 0 0
Triglyceride catabolism R-HSA-163560 8.658198e-01 0.063 0 0
G1/S-Specific Transcription R-HSA-69205 8.658198e-01 0.063 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.658198e-01 0.063 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.667698e-01 0.062 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.667698e-01 0.062 0 0
Laminin interactions R-HSA-3000157 8.667698e-01 0.062 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.708429e-01 0.060 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.708429e-01 0.060 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.708429e-01 0.060 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.708429e-01 0.060 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.708429e-01 0.060 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.708429e-01 0.060 0 0
Hydrolysis of LPC R-HSA-1483115 8.708429e-01 0.060 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.708429e-01 0.060 0 0
Physiological factors R-HSA-5578768 8.708429e-01 0.060 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.708429e-01 0.060 0 0
Malate-aspartate shuttle R-HSA-9856872 8.708429e-01 0.060 0 0
HDL assembly R-HSA-8963896 8.708429e-01 0.060 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.708429e-01 0.060 0 0
Zinc transporters R-HSA-435354 8.708429e-01 0.060 0 0
Stimuli-sensing channels R-HSA-2672351 8.732120e-01 0.059 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.757195e-01 0.058 0 0
Extension of Telomeres R-HSA-180786 8.765598e-01 0.057 0 0
Triglyceride metabolism R-HSA-8979227 8.765598e-01 0.057 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.775862e-01 0.057 0 0
MET activates PTK2 signaling R-HSA-8874081 8.781139e-01 0.056 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.781139e-01 0.056 0 0
TRP channels R-HSA-3295583 8.781139e-01 0.056 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.781139e-01 0.056 0 0
Sphingolipid catabolism R-HSA-9845614 8.781139e-01 0.056 0 0
NGF-stimulated transcription R-HSA-9031628 8.788782e-01 0.056 0 0
Metal ion SLC transporters R-HSA-425410 8.788782e-01 0.056 0 0
tRNA Aminoacylation R-HSA-379724 8.841993e-01 0.053 0 0
Metabolism of polyamines R-HSA-351202 8.841993e-01 0.053 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.847325e-01 0.053 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.847325e-01 0.053 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.847325e-01 0.053 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.847325e-01 0.053 0 0
Other semaphorin interactions R-HSA-416700 8.847325e-01 0.053 0 0
Signaling by Activin R-HSA-1502540 8.847325e-01 0.053 1 1
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.849656e-01 0.053 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.849656e-01 0.053 0 0
Cristae formation R-HSA-8949613 8.885598e-01 0.051 0 0
Triglyceride biosynthesis R-HSA-75109 8.885598e-01 0.051 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.885598e-01 0.051 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.918284e-01 0.050 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.935925e-01 0.049 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.960580e-01 0.048 0 0
Post-translational protein modification R-HSA-597592 8.965210e-01 0.047 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.971292e-01 0.047 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.971292e-01 0.047 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.971292e-01 0.047 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.971292e-01 0.047 0 0
Killing mechanisms R-HSA-9664420 8.971292e-01 0.047 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.971292e-01 0.047 0 0
Fructose catabolism R-HSA-70350 8.971292e-01 0.047 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.971292e-01 0.047 0 0
Attachment and Entry R-HSA-9678110 8.971292e-01 0.047 0 0
Virus Assembly and Release R-HSA-168268 8.971292e-01 0.047 0 0
Telomere Extension By Telomerase R-HSA-171319 8.981695e-01 0.047 0 0
Prednisone ADME R-HSA-9757110 8.981695e-01 0.047 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.076274e-01 0.042 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.081932e-01 0.042 0 0
Phase 2 - plateau phase R-HSA-5576893 9.081932e-01 0.042 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.081932e-01 0.042 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.081932e-01 0.042 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.081932e-01 0.042 0 0
Coenzyme A biosynthesis R-HSA-196783 9.081932e-01 0.042 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.081932e-01 0.042 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.081932e-01 0.042 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.081932e-01 0.042 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.087260e-01 0.042 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.091222e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.091222e-01 0.041 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.132479e-01 0.039 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.132479e-01 0.039 0 0
Extracellular matrix organization R-HSA-1474244 9.141754e-01 0.039 0 0
Infectious disease R-HSA-5663205 9.160110e-01 0.038 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.160895e-01 0.038 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.160895e-01 0.038 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.179500e-01 0.037 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.180679e-01 0.037 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.180679e-01 0.037 0 0
Catecholamine biosynthesis R-HSA-209905 9.180679e-01 0.037 0 0
Choline catabolism R-HSA-6798163 9.180679e-01 0.037 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.180679e-01 0.037 0 0
Pyruvate metabolism R-HSA-70268 9.182278e-01 0.037 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.220095e-01 0.035 0 0
Cargo concentration in the ER R-HSA-5694530 9.225562e-01 0.035 0 0
Activation of GABAB receptors R-HSA-991365 9.225665e-01 0.035 0 0
GABA B receptor activation R-HSA-977444 9.225665e-01 0.035 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.225665e-01 0.035 0 0
Kidney development R-HSA-9830369 9.271196e-01 0.033 0 0
Mitochondrial biogenesis R-HSA-1592230 9.272228e-01 0.033 0 0
Disease R-HSA-1643685 9.288229e-01 0.032 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.293808e-01 0.032 0 0
SLC transporter disorders R-HSA-5619102 9.302325e-01 0.031 0 0
Base Excision Repair R-HSA-73884 9.317090e-01 0.031 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.317878e-01 0.031 0 0
Conjugation of carboxylic acids R-HSA-159424 9.347466e-01 0.029 0 0
Amino Acid conjugation R-HSA-156587 9.347466e-01 0.029 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.347466e-01 0.029 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.347466e-01 0.029 0 0
Diseases of hemostasis R-HSA-9671793 9.347466e-01 0.029 0 0
Maturation of nucleoprotein R-HSA-9694631 9.347466e-01 0.029 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.356337e-01 0.029 0 0
Parasitic Infection Pathways R-HSA-9824443 9.386919e-01 0.027 0 0
Leishmania infection R-HSA-9658195 9.386919e-01 0.027 0 0
Metabolism of proteins R-HSA-392499 9.401210e-01 0.027 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.412312e-01 0.026 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.413591e-01 0.026 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.413591e-01 0.026 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.413591e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.417664e-01 0.026 0 0
Creatine metabolism R-HSA-71288 9.417664e-01 0.026 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.417664e-01 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.417664e-01 0.026 0 0
Signaling by NODAL R-HSA-1181150 9.417664e-01 0.026 1 1
Leishmania phagocytosis R-HSA-9664417 9.419875e-01 0.026 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.419875e-01 0.026 0 0
Parasite infection R-HSA-9664407 9.419875e-01 0.026 0 0
Signaling by Insulin receptor R-HSA-74752 9.431992e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.441439e-01 0.025 0 0
eNOS activation R-HSA-203615 9.465981e-01 0.024 0 0
RA biosynthesis pathway R-HSA-5365859 9.465981e-01 0.024 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.465981e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.480315e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.480315e-01 0.023 0 0
Phenylalanine metabolism R-HSA-8964208 9.480315e-01 0.023 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.480315e-01 0.023 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.480315e-01 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.480315e-01 0.023 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.485882e-01 0.023 0 0
RAB geranylgeranylation R-HSA-8873719 9.494675e-01 0.023 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.513889e-01 0.022 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.513889e-01 0.022 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.513889e-01 0.022 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.536228e-01 0.021 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.536228e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.536228e-01 0.021 0 0
Mitochondrial protein import R-HSA-1268020 9.566316e-01 0.019 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.566316e-01 0.019 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.566316e-01 0.019 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.586129e-01 0.018 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.586129e-01 0.018 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.586129e-01 0.018 0 0
Cellular hexose transport R-HSA-189200 9.586129e-01 0.018 0 0
LDL clearance R-HSA-8964038 9.586129e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.586129e-01 0.018 0 0
Cleavage of the damaged purine R-HSA-110331 9.597668e-01 0.018 0 0
Peptide hormone metabolism R-HSA-2980736 9.608770e-01 0.017 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.630663e-01 0.016 0 0
Formation of the ureteric bud R-HSA-9830674 9.630663e-01 0.016 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.630663e-01 0.016 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.630663e-01 0.016 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.630663e-01 0.016 0 0
Carnitine shuttle R-HSA-200425 9.630663e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.630663e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.632682e-01 0.016 0 0
Depurination R-HSA-73927 9.634180e-01 0.016 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.670407e-01 0.015 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.670407e-01 0.015 0 0
Interleukin-6 family signaling R-HSA-6783589 9.670407e-01 0.015 0 0
G alpha (s) signalling events R-HSA-418555 9.673537e-01 0.014 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.690319e-01 0.014 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.697879e-01 0.013 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.705877e-01 0.013 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.705877e-01 0.013 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.705877e-01 0.013 0 0
Formation of the nephric duct R-HSA-9830364 9.705877e-01 0.013 0 0
Abacavir ADME R-HSA-2161522 9.737531e-01 0.012 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.757743e-01 0.011 0 0
Packaging Of Telomere Ends R-HSA-171306 9.765780e-01 0.010 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.765780e-01 0.010 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.765780e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.765780e-01 0.010 0 0
Synthesis of PE R-HSA-1483213 9.765780e-01 0.010 0 0
RSV-host interactions R-HSA-9833110 9.771027e-01 0.010 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.773403e-01 0.010 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.773403e-01 0.010 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.773403e-01 0.010 0 0
Mitochondrial protein degradation R-HSA-9837999 9.775371e-01 0.010 0 0
HCMV Late Events R-HSA-9610379 9.779294e-01 0.010 0 0
ECM proteoglycans R-HSA-3000178 9.786614e-01 0.009 0 0
Insulin receptor recycling R-HSA-77387 9.790991e-01 0.009 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.790991e-01 0.009 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.790991e-01 0.009 0 0
Thyroxine biosynthesis R-HSA-209968 9.813489e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.813489e-01 0.008 0 0
Amine ligand-binding receptors R-HSA-375280 9.813771e-01 0.008 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.824773e-01 0.008 0 0
GABA receptor activation R-HSA-977443 9.831639e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.833566e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.833566e-01 0.007 0 0
Synthesis of PC R-HSA-1483191 9.861169e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.867473e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.874182e-01 0.005 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.879656e-01 0.005 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.879656e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.886003e-01 0.005 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.894475e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.905838e-01 0.004 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.905838e-01 0.004 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.906485e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.906485e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.908299e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.915978e-01 0.004 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.930634e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.931439e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.933101e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.933101e-01 0.003 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.933101e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.933101e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.933101e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.937428e-01 0.003 0 0
Metal ion assimilation from the host R-HSA-9638482 9.937428e-01 0.003 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.940306e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.943220e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.943971e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.946736e-01 0.002 0 0
Aspirin ADME R-HSA-9749641 9.947921e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.952473e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.952473e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.956849e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.957593e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.958010e-01 0.002 0 0
PI Metabolism R-HSA-1483255 9.959024e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.962042e-01 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.962252e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.965623e-01 0.001 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.966238e-01 0.001 0 0
Depyrimidination R-HSA-73928 9.966238e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.969707e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.972263e-01 0.001 0 0
Methylation R-HSA-156581 9.973122e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.978652e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.980222e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.983176e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.983232e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.983610e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.986339e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.986440e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.986440e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.988839e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.989293e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.990413e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991808e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.992609e-01 0.000 0 0
Digestion R-HSA-8935690 9.993161e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.993850e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.993850e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.993898e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.994074e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994586e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.995569e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996015e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996134e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996352e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996691e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.996782e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.996923e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997255e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997255e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997596e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997943e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998051e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998262e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998617e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998766e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998766e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998878e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998899e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998917e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998984e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999124e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999129e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999192e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999260e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999269e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999334e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999408e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999606e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999606e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999744e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.999792e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.999827e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999830e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999845e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999894e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999897e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999904e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999913e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999921e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999937e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999960e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999973e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999977e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999987e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999992e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999993e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999996e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Regulation of signaling by NODAL R-HSA-1433617 1.000000e+00 0.000 1 1
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
TGFBR3 regulates activin signaling R-HSA-9839406 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways