CDK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00267 T806 Sugiyama SUPT5H SPT5 SPT5H MYGsQtPLQDGsRtPHyGsQtPLHDGsRtPAQsGAWDPNNP
O14497 S363 Sugiyama ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1 AAAAAAASGGAQQRsHHAPMsPGssGGGGQPLARtPQPssP
O15151 S314 EPSD|PSP MDM4 MDMX TDVEVTSEDEWQCTECKKFNsPSKRYCFRCWALRKDWYSDC
O43791 S6 EPSD|PSP SPOP _______________MsRVPsPPPPAEMSSGPVAESWCYTQ
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60292 S158 Sugiyama SIPA1L3 KIAA0545 SPAL3 FHRLSRRRsKDVEFQDGWPRsPGRAFLPLRHRsssEItLSE
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04179 S106 EPSD|PSP SOD2 PALKFNGGGHINHSIFWTNLsPNGGGEPKGELLEAIKRDFG
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S177 Sugiyama ALPP PLAP RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06400 S249 SIGNOR|PSP RB1 LsPPMLLKEPYKTAVIPINGsPRtPRRGQNRSARIAKQLEN
P06400 S608 EPSD|PSP RB1 sACPLNLPLQNNHtAADMyLsPVRsPKKKGSTTRVNstANA
P06400 S612 EPSD|PSP RB1 LNLPLQNNHtAADMyLsPVRsPKKKGSTTRVNstANAETQA
P06400 S780 SIGNOR|iPTMNet|EPSD|PSP RB1 FMQRLKtNILQyAstRPPtLsPIPHIPRsPyKFPssPLRIP
P06400 S788 SIGNOR|iPTMNet|EPSD|PSP RB1 ILQyAstRPPtLsPIPHIPRsPyKFPssPLRIPGGNIyIsP
P06400 S795 SIGNOR|iPTMNet|EPSD|PSP RB1 RPPtLsPIPHIPRsPyKFPssPLRIPGGNIyIsPLKsPYKI
P06400 S807 EPSD|PSP RB1 RsPyKFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtP
P06400 S811 SIGNOR|EPSD|PSP RB1 KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06400 T252 EPSD|PSP RB1 PMLLKEPYKTAVIPINGsPRtPRRGQNRSARIAKQLENDTR
P06400 T356 SIGNOR|iPTMNet|EPSD|PSP RB1 FLDHDKTLQTDsIDsFEtQRtPRKsNLDEEVNVIPPHtPVR
P06400 T373 EPSD|PSP RB1 tQRtPRKsNLDEEVNVIPPHtPVRTVMNTIQQLMMILNSAS
P06400 T5 SIGNOR|iPTMNet RB1 ________________MPPKtPRKTAATAAAAAAEPPAPPP
P06400 T826 GPS6|SIGNOR|iPTMNet|EPSD|PSP RB1 IsPLKsPYKIsEGLPtPtKMtPRSRILVSIGEsFGtsEKFQ
P06733 S272 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P07814 S886 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLFD
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P09923 S174 Sugiyama ALPI RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11802 S28 Sugiyama CDK4 PVAEIGVGAyGTVYKARDPHsGHFVALKSVRVPNGGGGGGG
P13051 S12 SIGNOR UNG DGU UNG1 UNG15 _________MIGQKtLysFFsPsPARKRHAPsPEPAVQGtG
P13051 S14 SIGNOR UNG DGU UNG1 UNG15 _______MIGQKtLysFFsPsPARKRHAPsPEPAVQGtGVA
P13051 S23 SIGNOR UNG DGU UNG1 UNG15 GQKtLysFFsPsPARKRHAPsPEPAVQGtGVAGVPEESGDA
P13051 T60 SIGNOR UNG DGU UNG1 UNG15 SGDAAAIPAKKAPAGQEEPGtPPssPLsAEQLDRIQRNKAA
P14866 S101 Sugiyama HNRNPL HNRPL P/OKcl.14 GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15923 S139 EPSD|PSP TCF3 BHLHB21 E2A ITF1 GLTQAGFLSGELALNSPGPLsPsGMKGTSQYYPSYsGssRR
P15923 S154 GPS6 TCF3 BHLHB21 E2A ITF1 SPGPLsPsGMKGTSQYYPSYsGssRRRAADGSLDTQPKKVR
P15923 S245 EPSD|PSP TCF3 BHLHB21 E2A ITF1 AELWsPPGQAGFGPMLGGGSsPLPLPPGSGPVGSSGSSSTF
P15923 S48 GPS6 TCF3 BHLHB21 E2A ITF1 LPVTNGKGRPAsLAGAQFGGsGLEDRPssGSWGSGDQSSSS
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17480 S484 GPS6|SIGNOR|ELM|iPTMNet|EPSD UBTF UBF UBF1 KAQSERKPGGEREERGKLPEsPKRAEEIWQQSVIGDYLARF
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P19484 S114 PSP TFEB BHLHE35 EYLsEtYGNKFAAHIsPAQGsPKPPPAAsPGVRAGHVLSss
P19484 S142 PSP TFEB BHLHE35 sPGVRAGHVLSssAGNsAPNsPMAMLHIGsNPERELDDVID
P19484 S467 PSP TFEB BHLHE35 SDPLLstMsPEAsKAssRRssFsMEEGDVL___________
P19484 T331 PSP TFEB BHLHE35 QLWLRIQELEMQARVHGLPttsPsGMNMAELAQQVVKQELP
P19532 S246 PSP TFE3 BHLHE33 QPLPAPEAAHTTGPTGSAPNsPMALLTIGSSSEKEIDDVID
P21333 S1459 PSP FLNA FLN FLN1 KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P21333 S2152 PSP FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P24385 S41 Sugiyama CCND1 BCL1 PRAD1 NLLNDRVLRAMLKAEETCAPsVsYFKCVQKEVLPSMRKIVA
P25205 T722 Sugiyama MCM3 GDsyDPyDFsDtEEEMPQVHtPKTADsQEtKEsQKVELsES
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26358 S127 EPSD|PSP DNMT1 AIM CXXC9 DNMT LENGNQARSEARRVGMADANsPPKPLSKPRTPRRsKsDGEA
P26358 S954 EPSD|PSP DNMT1 AIM CXXC9 DNMT RVGDGVYLPPEAFTFNIKLssPVKRPRKEPVDEDLyPEHyR
P27824 S583 Sugiyama CANX VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P28749 S640 GPS6|ELM|iPTMNet|EPSD|PSP RBL1 PRVKEVRTDSGSLRRDMQPLsPISVHERYSsPtAGSAKRRL
P28749 S650 GPS6|SIGNOR|ELM|iPTMNet|EPSD RBL1 GSLRRDMQPLsPISVHERYSsPtAGSAKRRLFGEDPPKEML
P28749 S964 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RBL1 SFALKYDLANQDHMMDAPPLsPFPHIKQQPGsPRRISQQHS
P28749 S975 GPS6|ELM|iPTMNet|EPSD|PSP RBL1 DHMMDAPPLsPFPHIKQQPGsPRRISQQHSIYIsPHKNGSG
P28749 T369 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RBL1 ANVEYNLQQHFEKKRSFAPstPLTGRRYLREKEAVItPVAS
P29692 S133 Sugiyama EEF1D EF1D NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P30281 S133 Sugiyama CCND3 LRETtPLtIEKLCIYtDHAVsPRQLRDWEVLVLGKLKWDLA
P30281 S273 Sugiyama CCND3 ESLREASQTSssPAPKAPRGsssQGPsQtstPtDVtAIHL_
P30281 S275 Sugiyama CCND3 LREASQTSssPAPKAPRGsssQGPsQtstPtDVtAIHL___
P30281 S279 Sugiyama CCND3 SQTSssPAPKAPRGsssQGPsQtstPtDVtAIHL_______
P30281 S282 Sugiyama CCND3 SssPAPKAPRGsssQGPsQtstPtDVtAIHL__________
P30281 S43 Sugiyama CCND3 GDQRVLQSLLRLEERyVPRAsyFQCVQREIKPHMRKMLAYW
P30281 T117 Sugiyama CCND3 AQLQLLGAVCMLLASKLRETtPLtIEKLCIYtDHAVsPRQL
P30281 T120 Sugiyama CCND3 QLLGAVCMLLASKLRETtPLtIEKLCIYtDHAVsPRQLRDW
P30281 T128 Sugiyama CCND3 LLASKLRETtPLtIEKLCIYtDHAVsPRQLRDWEVLVLGKL
P30281 T281 Sugiyama CCND3 TSssPAPKAPRGsssQGPsQtstPtDVtAIHL_________
P30281 T283 Sugiyama CCND3 ssPAPKAPRGsssQGPsQtstPtDVtAIHL___________
P30281 T288 Sugiyama CCND3 KAPRGsssQGPsQtstPtDVtAIHL________________
P30281 Y44 Sugiyama CCND3 DQRVLQSLLRLEERyVPRAsyFQCVQREIKPHMRKMLAYWM
P30304 S40 SIGNOR|PSP CDC25A PPASQPVVKALFGASAAGGLsPVTNLTVTMDQLQGLGSDyE
P30304 S88 SIGNOR CDC25A NSNLQRMGsSEstDsGFCLDsPGPLDSKENLENPMRRIHsL
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35998 T193 Sugiyama PSMC2 MSS1 TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P38398 S632 SIGNOR|EPSD|PSP BRCA1 RNF53 RRKSSTRHIHALELVVSRNLsPPNCTELQIDSCSSSEEIKK
P38936 S130 PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 HVDLsLSCTLVPRsGEQAEGsPGGPGDSQGRKRRQtsMTDF
P38936 S98 PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 LPtGPRRGRDELGGGRRPGtsPALLQGTAEEDHVDLsLSCT
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43694 S105 SIGNOR|EPSD|PSP GATA4 GSPGWSQAGADGAAYTPPPVsPRFSFPGTTGSLAAAAAAAA
P46108 S41 Sugiyama CRK QEAVALLQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYI
P46937 T119 Sugiyama YAP1 YAP65 PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49815 S1217 SIGNOR|PSP TSC2 TSC4 ILVRRPTGNTSWLMSLENPLsPFSSDINNMPLQELSNALMA
P49815 S1452 SIGNOR|PSP TSC2 TSC4 ASGEDSRGQPEGPLPsssPRsPsGLRPRGYtIsDsAPsRRG
P50552 T76 Sugiyama VASP PDQQVVINCAIVRGVKYNQAtPNFHQWRDARQVWGLNFGSK
P51991 S358 Sugiyama HNRNPA3 HNRPA3 QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55072 S664 PSP VCP HEL-220 HEL-S-70 yIPLPDEKSRVAILKANLRKsPVAKDVDLEFLAKMTNGFSG
P55072 T509 PSP VCP HEL-220 HEL-S-70 LQELVQyPVEHPDKFLKFGMtPSKGVLFYGPPGCGKTLLAK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62750 S43 Sugiyama RPL23A KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P84022 S204 SIGNOR|iPTMNet|EPSD|PSP SMAD3 MADH3 YLSEDGETSDHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPV
P84022 S208 SIGNOR|iPTMNet|EPSD|PSP SMAD3 MADH3 DGETSDHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCE
P84022 S213 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD3 MADH3 DHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCEPAFWC
P84022 T179 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD3 MADH3 SIPENTNFPAGIEPQSNIPEtPPPGYLSEDGETSDHQMNHS
P84022 T8 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD3 MADH3 _____________MSsILPFtPPIVKRLLGWKKGEQNGQEE
Q04637 S1231 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI tEDRDRGRDAVKREAALPPVsPLKAALsEEELEKKsKAIIE
Q06830 T90 SIGNOR PRDX1 PAGA PAGB TDPX2 NCQVIGASVDSHFCHLAWVNtPKKQGGLGPMNIPLVSDPKR
Q08050 S35 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN RLPLPVQNAPSETSEEEPKRsPAQQESNQAEASKEVAESNS
Q08050 S4 SIGNOR|EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN _________________MKTsPRRPLILKRRRLPLPVQNAP
Q08050 S451 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN APLSSAGPGKEEKLLFGEGFsPLLPVQTIKEEEIQPGEEMP
Q08050 S489 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN EMPHLARPIKVEsPPLEEWPsPAPSFKEEssHsWEDssQsP
Q08050 S508 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PsPAPSFKEEssHsWEDssQsPtPRPKKSYSGLRsPTRCVS
Q08050 S522 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN WEDssQsPtPRPKKSYSGLRsPTRCVSEMLVIQHRERRERS
Q08050 S704 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN LIsVPFGNssPsDIDVPKPGsPEPQVsGLAANRsLtEGLVL
Q08050 T510 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PAPSFKEEssHsWEDssQsPtPRPKKSYSGLRsPTRCVSEM
Q08050 T600 EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN DSSDPASQLSYSQEVGGPFKtPIKETLPISStPsKSVLPRt
Q08050 T611 SIGNOR|EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN SQEVGGPFKtPIKETLPISStPsKSVLPRtPEsWRLtPPAK
Q08050 T620 SIGNOR|EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN tPIKETLPISStPsKSVLPRtPEsWRLtPPAKVGGLDFsPV
Q08050 T627 SIGNOR|EPSD|PSP FOXM1 FKHL16 HFH11 MPP2 WIN PISStPsKSVLPRtPEsWRLtPPAKVGGLDFsPVQTSQGAS
Q08999 S1035 GPS6|ELM|iPTMNet|EPSD|PSP RBL2 RB2 KQIKTFAMKYSQANMDAPPLsPYPFVRtGsPRRIQLSQNHP
Q08999 S672 GPS6|ELM|iPTMNet|EPSD|PSP RBL2 RB2 DTGGLGRsItsPTtLyDRYssPPAStTRRRLFVENDsPsDG
Q08999 T401 GPS6|ELM|iPTMNet|EPSD|PSP RBL2 RB2 VQMKNILQQHFDKSKALRIStPLTGVRyIKENsPCVtPVST
Q12778 S249 EPSD|PSP FOXO1 FKHR FOXO1A EGTGKssWWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSR
Q13200 S16 Sugiyama PSMD2 TRAP2 _____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13242 S211 Sugiyama SRSF9 SFRS9 SRP30C GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242 S216 Sugiyama SRSF9 SFRS9 SRP30C RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13573 S232 Sugiyama SNW1 SKIIP SKIP FKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQEWKIPPCIS
Q13761 S356 SIGNOR|EPSD|PSP RUNX3 AML2 CBFA3 PEBP2A3 TSSGSYQFSMVAGSSSGGDRsPTRMLASCTSSAASVAAGNL
Q13950 S465 PSP RUNX2 AML3 CBFA1 OSF2 PEBP2A LYYGTSsGSYQFPMVPGGDRsPSRMLPPCTTTSNGSTLLNP
Q14106 S254 SIGNOR|PSP TOB2 KIAA1663 TOB4 TROB2 SLSMHSLNFITANPAPQSQLsPNAKEFVYNGGGSPSLFFDA
Q14157 S416 Sugiyama UBAP2L KIAA0144 NICE4 tQsPsLVQYDLKNPsDsAVHsPFtKRQAFtPsstMMEVFLQ
Q14247 S117 Sugiyama CTTN EMS1 KsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVDQsAV
Q14814 S110 SIGNOR|EPSD|PSP MEF2D KKGFNGCDsPEPDGEDsLEQsPLLEDKyRRAsEELDGLFRR
Q14814 S98 SIGNOR|EPSD|PSP MEF2D SRTNADIIETLRKKGFNGCDsPEPDGEDsLEQsPLLEDKyR
Q14980 S1757 Sugiyama NUMA1 NMP22 NUMA ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15154 S69 Sugiyama PCM1 KKKFGVESDKRVTNDISPESsPGVGRRRTKTPHTFPHSRYM
Q15642 T302 Sugiyama TRIP10 CIP4 STOT STP VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q6P1L8 S49 Sugiyama MRPL14 MRPL32 RPML32 LSAIQKMTRVRVVDNSALGNsPyHRAPRCIHVYKKNGVGKV
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q8IZL8 S477 SIGNOR|EPSD|PSP PELP1 HMX3 MNAR ALLTHLLSDISPPADALKLRsPRGsPDGsLQtGKPSAPKKL
Q8IZL8 S991 SIGNOR PELP1 HMX3 MNAR EVEEGAPPPPTLPPALPPPEsPPKVQPEPEPEPGLLLEVEE
Q8NFG4 S571 PSP FLCN BHD KFWMTGLSKTYKSHLMstVRsPTASESRN____________
Q8NFG4 S62 PSP FLCN BHD GEQAEEEEGGIQMNSRMRAHsPAEGAsVEsssPGPKKSDMC
Q8NFG4 S73 PSP FLCN BHD QMNSRMRAHsPAEGAsVEsssPGPKKSDMCEGCRSLAAGHP
Q92830 S372 SIGNOR|PSP KAT2A GCN5 GCN5L2 ILTHFPKFLSMLEEEIYGANsPIWESGFTMPPSEGTQLVPR
Q92830 T272 SIGNOR|PSP KAT2A GCN5 GCN5L2 QTMFELSKMFLLCLNYWKLEtPAQFRQRSQAEDVATYKVNY
Q92879 S302 SIGNOR|EPSD|PSP CELF1 BRUNOL2 CUGBP CUGBP1 NAB50 NALTTSSSPLSVLTSSGSsPsSSSSNSVNPIASLGALQTLA
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96FS4 T64 Sugiyama SIPA1 SPA1 RPVRGPLLRsGsDAGEARPPtPAsPRARAHsHEEAsRPAAT
Q96KS0 S130 EPSD|PSP EGLN2 EIT6 QGARPEAPKRKWAEDGGDAPsPsKRPWARQENQEAEREGGM
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q9BQA1 S264 EPSD|PSP WDR77 MEP50 WD45 HKMT1069 Nbla10071 STSCVLSSAVHSQCVTGLVFsPHSVPFLASLSEDCSLAVLD
Q9BQA1 S306 EPSD|PSP WDR77 MEP50 WD45 HKMT1069 Nbla10071 SLSELFRSQAHRDFVRDATWsPLNHSLLTTVGWDHQVVHHV
Q9BQA1 T5 EPSD|PSP WDR77 MEP50 WD45 HKMT1069 Nbla10071 ________________MRKEtPPPLVPPAAREWNLPPNAPA
Q9BR84 S197 Sugiyama ZNF559 KTHTQEKPYKCSDCEKGLPSssHLRECVRIYGGERPYTHKE
Q9BR84 S198 Sugiyama ZNF559 THTQEKPYKCSDCEKGLPSssHLRECVRIYGGERPYTHKEY
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9NS23 S207 SIGNOR RASSF1 RDA32 PsLQDARRGPGRGTSVRRRtsFYLPKDAVKHLHVLSRTRAR
Q9NS64 S98 PSP RPRM CNLLIKSEGMINFLVKDRRPsKEVEAVVVGPY_________
Q9NYF8 S290 Sugiyama BCLAF1 BTF KIAA0164 ERsGsGsVGNGssRysPsQNsPIHHIPsRRsPAKtIAPQNA
Q9NZB2 T991 Sugiyama FAM120A C9orf10 KIAA0183 OSSA PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2694 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2 S41 Sugiyama CARHSP1 LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y5U2 S146 Sugiyama TSSC4 LAPsGRsPVEGLGRAHRsPAsPRVPPVPDYVAHPERWTKYS
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 3.421352e-08 7.466 1 0
Cell Cycle R-HSA-1640170 8.448693e-08 7.073 1 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.998167e-06 5.155 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.877404e-05 4.726 0 0
Chromatin organization R-HSA-4839726 4.058844e-05 4.392 1 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.263435e-05 4.203 0 0
G0 and Early G1 R-HSA-1538133 7.838031e-05 4.106 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.085091e-04 3.965 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.172915e-04 3.931 0 0
Chromatin modifying enzymes R-HSA-3247509 1.698326e-04 3.770 1 0
G1/S-Specific Transcription R-HSA-69205 2.103936e-04 3.677 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.765619e-04 3.424 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.623987e-04 3.118 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.426903e-04 3.129 0 0
Cell Cycle Checkpoints R-HSA-69620 7.278900e-04 3.138 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.773085e-04 3.057 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.080158e-03 2.967 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.144891e-03 2.941 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.144891e-03 2.941 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.340599e-03 2.873 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.410023e-03 2.851 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 1.831537e-03 2.737 0 0
Gene expression (Transcription) R-HSA-74160 1.992025e-03 2.701 1 0
Polo-like kinase mediated events R-HSA-156711 2.170700e-03 2.663 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.304941e-03 2.637 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.332329e-03 2.632 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.671257e-03 2.573 0 0
HIV Life Cycle R-HSA-162587 2.792958e-03 2.554 0 0
G2/M Transition R-HSA-69275 3.718485e-03 2.430 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.050371e-03 2.393 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.976253e-03 2.401 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.154349e-03 2.381 0 0
HATs acetylate histones R-HSA-3214847 4.619190e-03 2.335 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.535930e-03 2.343 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.938257e-03 2.306 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.154194e-03 2.288 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 5.882474e-03 2.230 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 5.882474e-03 2.230 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.834870e-03 2.234 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.607988e-03 2.180 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.593860e-03 2.181 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.688600e-03 2.175 0 0
G1/S Transition R-HSA-69206 6.997495e-03 2.155 1 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.604513e-03 2.119 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.604513e-03 2.119 0 0
Deadenylation of mRNA R-HSA-429947 7.714750e-03 2.113 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.261815e-03 2.139 0 0
mRNA 3'-end processing R-HSA-72187 7.870379e-03 2.104 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.340413e-03 2.079 0 0
Nuclear import of Rev protein R-HSA-180746 9.457333e-03 2.024 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.035757e-02 1.985 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.589059e-03 2.018 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.011243e-02 1.995 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.089316e-02 1.963 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.089316e-02 1.963 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.042024e-02 1.982 0 0
NRAGE signals death through JNK R-HSA-193648 1.159565e-02 1.936 0 0
Apoptotic execution phase R-HSA-75153 1.267588e-02 1.897 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.346255e-02 1.871 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.346636e-02 1.871 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.388971e-02 1.857 0 0
M Phase R-HSA-68886 1.469674e-02 1.833 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.488580e-02 1.827 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.960020e-02 1.708 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.960020e-02 1.708 0 0
SOS-mediated signalling R-HSA-112412 1.960020e-02 1.708 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.745915e-02 1.758 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.855784e-02 1.731 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.855784e-02 1.731 0 0
Heme signaling R-HSA-9707616 1.945965e-02 1.711 0 0
Signaling by ALK R-HSA-201556 1.673000e-02 1.777 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.965393e-02 1.707 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.965393e-02 1.707 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.976526e-02 1.704 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.977906e-02 1.704 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.052134e-02 1.688 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.120633e-02 1.674 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 2.185418e-02 1.660 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 2.185418e-02 1.660 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.202924e-02 1.657 1 0
Circadian clock R-HSA-9909396 2.313883e-02 1.636 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.332694e-02 1.632 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.459079e-02 1.609 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.459079e-02 1.609 0 0
Nuclear RNA decay R-HSA-9930044 2.459079e-02 1.609 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.459079e-02 1.609 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.765348e-02 1.558 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.765348e-02 1.558 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.734389e-02 1.563 0 0
Regulation of TP53 Activity R-HSA-5633007 2.687931e-02 1.571 0 0
S Phase R-HSA-69242 2.895713e-02 1.538 1 0
Mitotic Anaphase R-HSA-68882 2.958879e-02 1.529 0 0
Separation of Sister Chromatids R-HSA-2467813 3.209693e-02 1.494 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.073896e-02 1.512 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.060559e-02 1.514 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.219797e-02 1.492 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.981807e-02 1.526 0 0
Long-term potentiation R-HSA-9620244 3.248889e-02 1.488 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.344363e-02 1.476 0 0
G2/M Checkpoints R-HSA-69481 3.347275e-02 1.475 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.514805e-02 1.454 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.715410e-02 1.430 0 0
Metabolism of non-coding RNA R-HSA-194441 3.845624e-02 1.415 0 0
snRNP Assembly R-HSA-191859 3.845624e-02 1.415 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.642178e-02 1.439 0 0
RET signaling R-HSA-8853659 3.679855e-02 1.434 0 0
Signal attenuation R-HSA-74749 3.811289e-02 1.419 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.845624e-02 1.415 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.574100e-02 1.447 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.013118e-02 1.397 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.083960e-02 1.389 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.160117e-02 1.381 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.279412e-02 1.369 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.570278e-02 1.340 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.557328e-02 1.341 0 0
HIV Infection R-HSA-162906 4.415760e-02 1.355 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.741824e-02 1.324 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.557470e-02 1.341 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.812288e-02 1.318 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.812288e-02 1.318 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.812288e-02 1.318 0 0
Signaling by TGFB family members R-HSA-9006936 4.867390e-02 1.313 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 5.476968e-02 1.261 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 5.476968e-02 1.261 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.476968e-02 1.261 0 0
IRS activation R-HSA-74713 5.998834e-02 1.222 0 0
Signaling by AXIN mutants R-HSA-4839735 5.400739e-02 1.268 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.450477e-02 1.264 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.498186e-02 1.260 1 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.232551e-02 1.281 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.138157e-02 1.212 0 0
HIV Transcription Initiation R-HSA-167161 6.138157e-02 1.212 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.138157e-02 1.212 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.158750e-02 1.211 0 0
Activation of the pre-replicative complex R-HSA-68962 5.498186e-02 1.260 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.400739e-02 1.268 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.110969e-02 1.214 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.991363e-02 1.302 0 0
Mitotic Prometaphase R-HSA-68877 5.947856e-02 1.226 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.498186e-02 1.260 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.533065e-02 1.257 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.674479e-02 1.246 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.110969e-02 1.214 0 0
NrCAM interactions R-HSA-447038 5.998834e-02 1.222 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.674479e-02 1.246 0 0
Signaling by NTRKs R-HSA-166520 5.299444e-02 1.276 0 0
G alpha (12/13) signalling events R-HSA-416482 5.788141e-02 1.237 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.788141e-02 1.237 0 0
Cellular Senescence R-HSA-2559583 6.274936e-02 1.202 1 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.296434e-02 1.201 0 0
Repression of WNT target genes R-HSA-4641265 6.296434e-02 1.201 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.811759e-02 1.167 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.811759e-02 1.167 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.130862e-02 1.147 0 0
Interleukin-6 signaling R-HSA-1059683 7.255961e-02 1.139 0 0
Signaling by WNT in cancer R-HSA-4791275 6.597673e-02 1.181 0 0
MTOR signalling R-HSA-165159 6.623623e-02 1.179 0 0
Homology Directed Repair R-HSA-5693538 7.465662e-02 1.127 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.255961e-02 1.139 0 0
Metabolism of RNA R-HSA-8953854 6.723904e-02 1.172 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.190093e-02 1.143 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.327481e-02 1.135 0 0
MAPK family signaling cascades R-HSA-5683057 6.930289e-02 1.159 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.190093e-02 1.143 0 0
Death Receptor Signaling R-HSA-73887 6.715692e-02 1.173 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.811759e-02 1.167 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.255961e-02 1.139 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.839573e-02 1.165 0 0
mTORC1-mediated signalling R-HSA-166208 7.552133e-02 1.122 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.552133e-02 1.122 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.557198e-02 1.122 0 0
Phosphorylation of Emi1 R-HSA-176417 7.557198e-02 1.122 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.557198e-02 1.122 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 7.557198e-02 1.122 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 7.557198e-02 1.122 0 0
G1 Phase R-HSA-69236 7.659810e-02 1.116 1 0
Cyclin D associated events in G1 R-HSA-69231 7.659810e-02 1.116 1 1
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.065428e-01 0.972 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.065428e-01 0.972 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.065428e-01 0.972 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.065428e-01 0.972 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.065428e-01 0.972 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 1.554830e-01 0.808 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 1.554830e-01 0.808 0 0
Defective VWF binding to collagen type I R-HSA-9845622 1.554830e-01 0.808 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 1.554830e-01 0.808 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 1.554830e-01 0.808 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 1.554830e-01 0.808 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 1.554830e-01 0.808 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.554830e-01 0.808 0 0
Defective OPLAH causes OPLAHD R-HSA-5578998 2.017453e-01 0.695 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 2.017453e-01 0.695 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.017453e-01 0.695 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.017453e-01 0.695 0 0
G2/M DNA replication checkpoint R-HSA-69478 9.226899e-02 1.035 0 0
DAG1 core M1 glycosylations R-HSA-8932506 1.099110e-01 0.959 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.099110e-01 0.959 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.454761e-01 0.610 0 0
MET activates PTPN11 R-HSA-8865999 2.454761e-01 0.610 0 0
Classical Kir channels R-HSA-1296053 2.454761e-01 0.610 0 0
Invadopodia formation R-HSA-8941237 2.454761e-01 0.610 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 2.454761e-01 0.610 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.454761e-01 0.610 0 0
DAG1 core M2 glycosylations R-HSA-8932504 1.283446e-01 0.892 0 0
MET receptor recycling R-HSA-8875656 1.283446e-01 0.892 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.283446e-01 0.892 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.283446e-01 0.892 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.283446e-01 0.892 0 0
ALK mutants bind TKIs R-HSA-9700645 1.474304e-01 0.831 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.868136e-01 0.542 0 0
HCN channels R-HSA-1296061 2.868136e-01 0.542 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.868136e-01 0.542 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.868136e-01 0.542 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.868136e-01 0.542 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.868136e-01 0.542 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.868136e-01 0.542 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.670420e-01 0.777 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.670420e-01 0.777 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.166951e-01 0.933 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.166951e-01 0.933 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.166951e-01 0.933 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.870646e-01 0.728 0 0
DAG1 core M3 glycosylations R-HSA-8932505 1.870646e-01 0.728 0 0
Signaling by APC mutants R-HSA-4839744 1.870646e-01 0.728 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.870646e-01 0.728 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.870646e-01 0.728 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.870646e-01 0.728 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 3.258887e-01 0.487 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.258887e-01 0.487 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.258887e-01 0.487 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.258887e-01 0.487 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.258887e-01 0.487 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.289955e-01 0.889 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.073945e-01 0.683 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.073945e-01 0.683 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.073945e-01 0.683 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.417305e-01 0.849 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.548632e-01 0.810 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.548632e-01 0.810 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.548632e-01 0.810 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.279382e-01 0.642 0 0
Polymerase switching R-HSA-69091 2.279382e-01 0.642 0 0
Leading Strand Synthesis R-HSA-69109 2.279382e-01 0.642 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.279382e-01 0.642 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.279382e-01 0.642 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.279382e-01 0.642 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.279382e-01 0.642 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.279382e-01 0.642 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.628252e-01 0.440 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.628252e-01 0.440 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.628252e-01 0.440 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.628252e-01 0.440 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.628252e-01 0.440 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.181299e-01 0.928 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.683570e-01 0.774 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.683570e-01 0.774 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.683570e-01 0.774 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.683570e-01 0.774 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.486114e-01 0.604 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.486114e-01 0.604 1 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.486114e-01 0.604 1 1
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.837548e-02 1.007 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.821757e-01 0.740 0 0
Late endosomal microautophagy R-HSA-9615710 1.375488e-01 0.862 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.210356e-02 1.086 0 0
Nucleosome assembly R-HSA-774815 8.210356e-02 1.086 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.210356e-02 1.086 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.962835e-01 0.707 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.693383e-01 0.570 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.977399e-01 0.400 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.977399e-01 0.400 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.977399e-01 0.400 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.977399e-01 0.400 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.900511e-01 0.538 0 0
Erythropoietin activates RAS R-HSA-9027284 2.900511e-01 0.538 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.900511e-01 0.538 0 0
Translesion synthesis by REV1 R-HSA-110312 2.900511e-01 0.538 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.900511e-01 0.538 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.900511e-01 0.538 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.900511e-01 0.538 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.900511e-01 0.538 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.252275e-01 0.647 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.252275e-01 0.647 0 0
Translesion synthesis by POLI R-HSA-5656121 3.106893e-01 0.508 0 0
Phosphorylation of the APC/C R-HSA-176412 3.106893e-01 0.508 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.307434e-01 0.366 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.307434e-01 0.366 0 0
Glycoprotein hormones R-HSA-209822 4.307434e-01 0.366 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.549202e-01 0.594 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.311989e-01 0.480 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.311989e-01 0.480 0 0
Translesion synthesis by POLK R-HSA-5655862 3.311989e-01 0.480 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.257191e-01 0.646 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.914907e-01 0.718 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.619403e-01 0.335 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.619403e-01 0.335 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.003190e-01 0.522 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.003190e-01 0.522 0 0
Signaling by Erythropoietin R-HSA-9006335 3.155668e-01 0.501 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.155668e-01 0.501 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.915062e-01 0.407 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.915062e-01 0.407 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.914292e-01 0.309 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.622945e-01 0.581 0 0
mRNA Splicing R-HSA-72172 8.822379e-02 1.054 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.110775e-01 0.386 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.110775e-01 0.386 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.193037e-01 0.285 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.193037e-01 0.285 0 0
DNA replication initiation R-HSA-68952 5.193037e-01 0.285 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.492480e-01 0.348 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.678027e-01 0.330 0 0
FGFR2 alternative splicing R-HSA-6803529 4.678027e-01 0.330 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.859796e-01 0.313 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.373099e-01 0.359 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.373099e-01 0.359 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.496367e-01 0.347 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.989353e-01 0.399 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.989353e-01 0.399 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.618763e-01 0.335 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.211451e-01 0.283 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.936065e-01 0.307 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.936065e-01 0.307 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.585279e-01 0.339 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.585279e-01 0.339 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.860577e-01 0.313 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.075129e-01 0.295 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.799495e-01 0.319 0 0
Centrosome maturation R-HSA-380287 5.010772e-01 0.300 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.330094e-01 0.273 0 0
Transcription of the HIV genome R-HSA-167172 1.414375e-01 0.849 0 0
HIV Transcription Elongation R-HSA-167169 4.936065e-01 0.307 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.810657e-02 1.107 0 0
RNA Polymerase III Transcription R-HSA-74158 9.837548e-02 1.007 0 0
mRNA Capping R-HSA-72086 3.155668e-01 0.501 0 0
Lagging Strand Synthesis R-HSA-69186 4.303328e-01 0.366 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.914907e-01 0.718 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.075599e-01 0.512 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.686762e-01 0.571 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.686762e-01 0.571 0 0
Nucleotide Excision Repair R-HSA-5696398 4.879366e-01 0.312 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.843913e-01 0.315 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.522732e-01 0.345 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.686762e-01 0.571 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.936065e-01 0.307 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.802937e-02 1.055 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.787168e-01 0.555 0 0
Aggrephagy R-HSA-9646399 4.936065e-01 0.307 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.477094e-01 0.831 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.851105e-01 0.545 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.492480e-01 0.348 0 0
Synthesis of DNA R-HSA-69239 3.569131e-01 0.447 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.477094e-01 0.831 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.670420e-01 0.777 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.962835e-01 0.707 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.904100e-01 0.537 0 0
Formation of apoptosome R-HSA-111458 1.670420e-01 0.777 0 0
PI3K/AKT activation R-HSA-198203 1.670420e-01 0.777 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.417305e-01 0.849 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.106455e-01 0.676 0 0
DNA strand elongation R-HSA-69190 3.612957e-01 0.442 0 0
Regulation of CDH11 function R-HSA-9762292 5.193037e-01 0.285 0 0
Peptide hormone biosynthesis R-HSA-209952 5.193037e-01 0.285 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.160116e-01 0.381 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.795077e-01 0.319 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.115163e-01 0.291 0 0
Myogenesis R-HSA-525793 2.699681e-01 0.569 0 0
RNA Polymerase I Transcription R-HSA-73864 5.321186e-01 0.274 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.474304e-01 0.831 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.492480e-01 0.348 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.065359e-01 0.391 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.678027e-01 0.330 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.211451e-01 0.283 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.375488e-01 0.862 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.341455e-01 0.872 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.868136e-01 0.542 0 0
Activation of RAC1 R-HSA-428540 2.073945e-01 0.683 0 0
TGFBR3 expression R-HSA-9839394 1.000144e-01 1.000 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.628252e-01 0.440 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.106455e-01 0.676 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.851105e-01 0.545 0 0
Gap junction degradation R-HSA-190873 4.914292e-01 0.309 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.914292e-01 0.309 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.065359e-01 0.391 0 0
Neurexins and neuroligins R-HSA-6794361 2.518000e-01 0.599 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.319267e-01 0.479 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.319267e-01 0.479 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.465996e-01 0.608 0 0
Apoptotic factor-mediated response R-HSA-111471 1.417305e-01 0.849 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.279382e-01 0.642 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.585279e-01 0.339 0 0
DNA Double Strand Break Response R-HSA-5693606 1.348570e-01 0.870 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.614550e-02 1.017 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.155668e-01 0.501 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.308281e-01 0.480 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.214160e-01 0.375 0 0
Frs2-mediated activation R-HSA-170968 2.486114e-01 0.604 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.909804e-01 0.719 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.592634e-01 0.586 1 1
Formation of the posterior neural plate R-HSA-9832991 1.870646e-01 0.728 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.258887e-01 0.487 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.258887e-01 0.487 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.073945e-01 0.683 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.628252e-01 0.440 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.798019e-01 0.745 0 0
PTK6 Expression R-HSA-8849473 4.307434e-01 0.366 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.308281e-01 0.480 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.914292e-01 0.309 0 0
Calcineurin activates NFAT R-HSA-2025928 4.914292e-01 0.309 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.116151e-01 0.506 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.764575e-01 0.424 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.214160e-01 0.375 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.764018e-01 0.424 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.629594e-01 0.580 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.786885e-01 0.748 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.617408e-01 0.442 0 0
DNA Replication R-HSA-69306 3.707244e-01 0.431 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.090148e-01 0.963 0 0
Adipogenesis R-HSA-9843745 4.466188e-01 0.350 1 0
Signaling by ERBB2 R-HSA-1227986 5.330094e-01 0.273 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.486114e-01 0.604 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.549202e-01 0.594 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.283023e-01 0.892 0 0
HSF1-dependent transactivation R-HSA-3371571 4.249054e-01 0.372 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.399964e-01 0.620 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.381132e-01 0.269 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.537995e-01 0.596 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.977399e-01 0.400 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.106455e-01 0.676 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.399964e-01 0.620 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.311989e-01 0.480 0 0
Insulin receptor signalling cascade R-HSA-74751 2.232502e-01 0.651 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.915438e-01 0.407 0 0
MET promotes cell motility R-HSA-8875878 2.497091e-01 0.603 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.970160e-01 0.705 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.150093e-01 0.382 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.381132e-01 0.269 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.381132e-01 0.269 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.416196e-02 1.075 0 0
Co-inhibition by PD-1 R-HSA-389948 2.580200e-01 0.588 0 0
TNF signaling R-HSA-75893 1.561585e-01 0.806 0 0
Signaling by Hippo R-HSA-2028269 3.515322e-01 0.454 0 0
Interleukin-6 family signaling R-HSA-6783589 2.399964e-01 0.620 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.914292e-01 0.309 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.276270e-01 0.894 0 0
IGF1R signaling cascade R-HSA-2428924 2.232502e-01 0.651 0 0
Signaling by WNT R-HSA-195721 1.927720e-01 0.715 0 0
Signaling by EGFR R-HSA-177929 1.561585e-01 0.806 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.977837e-01 0.526 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 2.017453e-01 0.695 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.226899e-02 1.035 0 0
MET interacts with TNS proteins R-HSA-8875513 2.454761e-01 0.610 0 0
Sodium/Proton exchangers R-HSA-425986 1.283446e-01 0.892 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.474304e-01 0.831 0 0
Alanine metabolism R-HSA-8964540 2.868136e-01 0.542 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.870646e-01 0.728 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.073945e-01 0.683 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.073945e-01 0.683 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.417305e-01 0.849 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.279382e-01 0.642 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.279382e-01 0.642 0 0
Sensory perception of salty taste R-HSA-9730628 3.628252e-01 0.440 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.486114e-01 0.604 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.210356e-02 1.086 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.977399e-01 0.400 0 0
Budding and maturation of HIV virion R-HSA-162588 1.581495e-01 0.801 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.873247e-02 1.006 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.307434e-01 0.366 0 0
Formation of annular gap junctions R-HSA-196025 4.619403e-01 0.335 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.716470e-01 0.430 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.155668e-01 0.501 0 0
Unwinding of DNA R-HSA-176974 4.914292e-01 0.309 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.361864e-01 0.627 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.193037e-01 0.285 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.065359e-01 0.391 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.211451e-01 0.283 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.866029e-01 0.543 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.477094e-01 0.831 0 0
Prolonged ERK activation events R-HSA-169893 3.106893e-01 0.508 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.322408e-01 0.634 0 0
Signalling to ERKs R-HSA-187687 9.134826e-02 1.039 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.276333e-02 1.082 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.716470e-01 0.430 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.472883e-01 0.607 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.914907e-01 0.718 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.962835e-01 0.707 0 0
Signaling by MET R-HSA-6806834 1.283023e-01 0.892 0 0
Ub-specific processing proteases R-HSA-5689880 2.006441e-01 0.698 0 0
IRS-mediated signalling R-HSA-112399 1.640131e-01 0.785 0 0
Collagen degradation R-HSA-1442490 3.489372e-01 0.457 0 0
Signaling by Insulin receptor R-HSA-74752 5.129620e-01 0.290 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.258887e-01 0.487 0 0
Rap1 signalling R-HSA-392517 3.915062e-01 0.407 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.919472e-01 0.717 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.065359e-01 0.391 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.737825e-01 0.563 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.740194e-01 0.324 0 0
Oncogene Induced Senescence R-HSA-2559585 2.139563e-01 0.670 1 1
Chromosome Maintenance R-HSA-73886 2.349113e-01 0.629 0 0
DCC mediated attractive signaling R-HSA-418885 2.900511e-01 0.538 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.678027e-01 0.330 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.160116e-01 0.381 0 0
Cellular response to heat stress R-HSA-3371556 1.459331e-01 0.836 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.561077e-01 0.807 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.329501e-02 1.030 0 0
EGFR downregulation R-HSA-182971 3.460787e-01 0.461 0 0
Ca2+ pathway R-HSA-4086398 1.765409e-01 0.753 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.276333e-02 1.082 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.354332e-02 1.029 0 0
Signaling by LTK R-HSA-9842663 2.279382e-01 0.642 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.628252e-01 0.440 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.656751e-02 1.063 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.307434e-01 0.366 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.619403e-01 0.335 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.914292e-01 0.309 0 0
Interleukin-27 signaling R-HSA-9020956 5.193037e-01 0.285 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.193037e-01 0.285 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.652269e-01 0.332 0 0
Autophagy R-HSA-9612973 2.800507e-01 0.553 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.934234e-01 0.307 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.515322e-01 0.454 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.515322e-01 0.454 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.329501e-02 1.030 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.329501e-02 1.030 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.329501e-02 1.030 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.329501e-02 1.030 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.099110e-01 0.959 0 0
Gene Silencing by RNA R-HSA-211000 7.800623e-02 1.108 0 0
Macroautophagy R-HSA-1632852 5.316028e-01 0.274 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.889417e-01 0.410 0 0
Adherens junctions interactions R-HSA-418990 1.934529e-01 0.713 0 0
Mitotic Prophase R-HSA-68875 8.119151e-02 1.090 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.075129e-01 0.295 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.294722e-01 0.482 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.115917e-01 0.952 0 0
Cell-cell junction organization R-HSA-421270 2.725976e-01 0.564 0 0
Signaling by ERBB4 R-HSA-1236394 4.905531e-01 0.309 0 0
Cell junction organization R-HSA-446728 1.779222e-01 0.750 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.709688e-01 0.431 0 0
SLC-mediated bile acid transport R-HSA-9958517 1.283446e-01 0.892 0 0
Sensory perception of sour taste R-HSA-9729555 2.868136e-01 0.542 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.628252e-01 0.440 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.693383e-01 0.570 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.977399e-01 0.400 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.977399e-01 0.400 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.062467e-01 0.974 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.252275e-01 0.647 0 0
VLDL clearance R-HSA-8964046 4.307434e-01 0.366 0 0
Disorders of Developmental Biology R-HSA-9675151 3.311989e-01 0.480 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.311989e-01 0.480 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.851105e-01 0.545 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.851105e-01 0.545 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.619403e-01 0.335 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.914292e-01 0.309 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.303328e-01 0.366 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.193037e-01 0.285 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.193037e-01 0.285 0 0
2-LTR circle formation R-HSA-164843 5.193037e-01 0.285 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.037642e-01 0.298 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.618763e-01 0.335 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.381132e-01 0.269 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.330094e-01 0.273 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.131583e-01 0.290 0 0
Signal Transduction R-HSA-162582 7.889946e-02 1.103 1 0
HCMV Late Events R-HSA-9610379 5.246326e-01 0.280 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.065359e-01 0.391 0 0
Deubiquitination R-HSA-5688426 1.519157e-01 0.818 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.209126e-01 0.283 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.458467e-01 0.836 0 0
Signaling by TGFBR3 R-HSA-9839373 1.914907e-01 0.718 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.303328e-01 0.366 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.303328e-01 0.366 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.474304e-01 0.831 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.000144e-01 1.000 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.000144e-01 1.000 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.550500e-01 0.810 1 0
Pyrimidine salvage R-HSA-73614 3.003190e-01 0.522 0 0
Signalling to RAS R-HSA-167044 4.303328e-01 0.366 0 0
Carnitine shuttle R-HSA-200425 4.859796e-01 0.313 0 0
Cell-Cell communication R-HSA-1500931 3.453755e-01 0.462 0 0
Cardiogenesis R-HSA-9733709 1.798019e-01 0.745 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.072471e-01 0.513 0 0
HDMs demethylate histones R-HSA-3214842 5.211451e-01 0.283 0 0
RNA Polymerase II Transcription R-HSA-73857 1.015137e-01 0.993 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.226899e-02 1.035 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.474304e-01 0.831 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.279382e-01 0.642 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.693383e-01 0.570 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.798019e-01 0.745 0 0
tRNA processing in the nucleus R-HSA-6784531 1.043401e-01 0.982 0 0
TBC/RABGAPs R-HSA-8854214 3.241994e-01 0.489 0 0
ERK/MAPK targets R-HSA-198753 4.303328e-01 0.366 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.193037e-01 0.285 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.214160e-01 0.375 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.124333e-01 0.385 0 0
Apoptosis R-HSA-109581 1.446177e-01 0.840 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.984517e-01 0.400 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.984517e-01 0.400 0 0
MHC class II antigen presentation R-HSA-2132295 5.072600e-01 0.295 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.678027e-01 0.330 0 0
Activation of BH3-only proteins R-HSA-114452 1.477094e-01 0.831 0 0
Signaling by NOTCH1 R-HSA-1980143 1.063005e-01 0.973 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.651022e-01 0.438 0 0
Generic Transcription Pathway R-HSA-212436 2.519277e-01 0.599 1 0
MECP2 regulates transcription factors R-HSA-9022707 1.099110e-01 0.959 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 2.868136e-01 0.542 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.258887e-01 0.487 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.279382e-01 0.642 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.962835e-01 0.707 0 0
NADPH regeneration R-HSA-389542 3.977399e-01 0.400 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.900511e-01 0.538 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.798019e-01 0.745 0 0
Regulation of PTEN localization R-HSA-8948747 4.307434e-01 0.366 0 0
RAF activation R-HSA-5673000 2.023710e-01 0.694 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.914292e-01 0.309 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.492480e-01 0.348 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.873295e-01 0.412 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.381132e-01 0.269 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.688526e-01 0.772 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.851105e-01 0.545 0 0
Regulation of beta-cell development R-HSA-186712 3.269699e-01 0.485 0 0
Programmed Cell Death R-HSA-5357801 2.910317e-01 0.536 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.279382e-01 0.642 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.800623e-02 1.108 0 0
Glutathione synthesis and recycling R-HSA-174403 4.492480e-01 0.348 0 0
Host Interactions of HIV factors R-HSA-162909 2.549837e-01 0.593 0 0
RUNX2 regulates bone development R-HSA-8941326 9.837548e-02 1.007 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.670420e-01 0.777 0 0
Glutathione conjugation R-HSA-156590 3.379394e-01 0.471 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.081532e-01 0.294 0 0
Signaling by ALK in cancer R-HSA-9700206 7.800623e-02 1.108 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.492480e-01 0.348 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.003190e-01 0.522 0 0
Signaling by PTK6 R-HSA-8848021 3.709804e-01 0.431 1 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.709804e-01 0.431 1 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.936065e-01 0.307 0 0
Post NMDA receptor activation events R-HSA-438064 2.991709e-01 0.524 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.283446e-01 0.892 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.354332e-02 1.029 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.289955e-01 0.889 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.628252e-01 0.440 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.782341e-02 1.056 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.693383e-01 0.570 0 0
HDL clearance R-HSA-8964011 3.977399e-01 0.400 0 0
Formation of the anterior neural plate R-HSA-9823739 2.900511e-01 0.538 0 0
Lipophagy R-HSA-9613354 4.914292e-01 0.309 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.914292e-01 0.309 0 0
MET activates PTK2 signaling R-HSA-8874081 5.381132e-01 0.269 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.212173e-01 0.283 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.381132e-01 0.269 0 0
Stimuli-sensing channels R-HSA-2672351 5.142329e-01 0.289 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.909804e-01 0.719 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.900511e-01 0.538 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.515322e-01 0.454 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.381132e-01 0.269 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.477225e-01 0.349 0 0
Glycolysis R-HSA-70171 2.910205e-01 0.536 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.743723e-01 0.324 1 1
Inositol phosphate metabolism R-HSA-1483249 1.671265e-01 0.777 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.693383e-01 0.570 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.106893e-01 0.508 0 0
PI3K Cascade R-HSA-109704 2.311488e-01 0.636 0 0
Negative regulation of MET activity R-HSA-6807004 4.110775e-01 0.386 0 0
Metalloprotease DUBs R-HSA-5689901 5.381132e-01 0.269 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.330094e-01 0.273 0 0
Signaling by NOTCH3 R-HSA-9012852 4.740194e-01 0.324 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.181299e-01 0.928 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.241994e-01 0.489 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.561585e-01 0.806 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.279763e-02 1.032 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.640131e-01 0.785 0 0
TNFs bind their physiological receptors R-HSA-5669034 5.037642e-01 0.298 0 0
Influenza Infection R-HSA-168255 4.390232e-01 0.358 0 0
L1CAM interactions R-HSA-373760 4.493775e-01 0.347 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.628252e-01 0.440 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.106455e-01 0.676 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.347119e-01 0.475 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.072600e-01 0.295 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.497059e-01 0.456 0 0
Mitochondrial biogenesis R-HSA-1592230 1.266694e-01 0.897 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.037642e-01 0.298 0 0
Neurodegenerative Diseases R-HSA-8863678 5.037642e-01 0.298 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.075129e-01 0.295 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.258887e-01 0.487 0 0
Assembly Of The HIV Virion R-HSA-175474 1.962835e-01 0.707 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.307434e-01 0.366 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.376424e-01 0.624 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.692724e-01 0.329 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.229562e-01 0.652 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.141777e-01 0.383 0 0
Signaling by Leptin R-HSA-2586552 1.670420e-01 0.777 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.678027e-01 0.330 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.330175e-01 0.273 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.361677e-01 0.360 0 0
Glucose metabolism R-HSA-70326 4.577340e-01 0.339 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.709804e-01 0.431 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.056308e-01 0.687 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.061227e-01 0.391 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.795077e-01 0.319 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.675606e-01 0.573 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 5.037642e-01 0.298 0 0
PI Metabolism R-HSA-1483255 3.072471e-01 0.513 0 0
Interleukin-7 signaling R-HSA-1266695 2.549202e-01 0.594 0 0
Growth hormone receptor signaling R-HSA-982772 2.252275e-01 0.647 0 0
Nephron development R-HSA-9831926 3.716470e-01 0.430 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.303328e-01 0.366 0 0
Triglyceride catabolism R-HSA-163560 4.361677e-01 0.360 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.023710e-01 0.694 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.347110e-01 0.272 0 0
Interleukin-2 family signaling R-HSA-451927 4.936065e-01 0.307 0 0
Maturation of hRSV A proteins R-HSA-9828806 2.851105e-01 0.545 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.733064e-02 1.012 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.795077e-01 0.319 0 0
MAP kinase activation R-HSA-450294 5.444132e-01 0.264 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.456519e-01 0.263 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.456519e-01 0.263 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.456519e-01 0.263 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.456519e-01 0.263 0 0
vRNA Synthesis R-HSA-192814 5.456519e-01 0.263 0 0
Hormone ligand-binding receptors R-HSA-375281 5.456519e-01 0.263 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.456519e-01 0.263 0 0
Chylomicron assembly R-HSA-8963888 5.456519e-01 0.263 0 0
Suppression of apoptosis R-HSA-9635465 5.456519e-01 0.263 0 0
PECAM1 interactions R-HSA-210990 5.456519e-01 0.263 0 0
Defective pyroptosis R-HSA-9710421 5.479864e-01 0.261 0 0
Signaling by FGFR4 R-HSA-5654743 5.479864e-01 0.261 0 0
HCMV Early Events R-HSA-9609690 5.517532e-01 0.258 0 0
Signaling by FGFR2 R-HSA-5654738 5.523212e-01 0.258 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.523212e-01 0.258 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.540151e-01 0.256 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.546613e-01 0.256 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.546613e-01 0.256 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.546613e-01 0.256 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.546613e-01 0.256 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.546613e-01 0.256 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 5.546613e-01 0.256 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.556715e-01 0.255 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.556715e-01 0.255 1 1
HCMV Infection R-HSA-9609646 5.565006e-01 0.255 0 0
Netrin-1 signaling R-HSA-373752 5.610367e-01 0.251 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.681497e-01 0.246 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.705575e-01 0.244 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.705575e-01 0.244 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.705575e-01 0.244 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.705575e-01 0.244 0 0
Integration of provirus R-HSA-162592 5.705575e-01 0.244 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.705575e-01 0.244 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.705575e-01 0.244 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.705575e-01 0.244 0 0
ERKs are inactivated R-HSA-202670 5.705575e-01 0.244 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.705575e-01 0.244 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.705575e-01 0.244 0 0
Anchoring fibril formation R-HSA-2214320 5.705575e-01 0.244 0 0
DS-GAG biosynthesis R-HSA-2022923 5.705575e-01 0.244 0 0
HIV elongation arrest and recovery R-HSA-167287 5.707846e-01 0.244 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.707846e-01 0.244 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.707846e-01 0.244 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.707846e-01 0.244 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.707846e-01 0.244 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.708332e-01 0.243 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.719586e-01 0.243 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.738561e-01 0.241 0 0
Signaling by FGFR3 R-HSA-5654741 5.738561e-01 0.241 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.738561e-01 0.241 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.817249e-01 0.235 0 0
ESR-mediated signaling R-HSA-8939211 5.861928e-01 0.232 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.864395e-01 0.232 0 0
Diseases of DNA repair R-HSA-9675135 5.864395e-01 0.232 0 0
DNA methylation R-HSA-5334118 5.864800e-01 0.232 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 5.864800e-01 0.232 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.864800e-01 0.232 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.864800e-01 0.232 0 0
Nervous system development R-HSA-9675108 5.911684e-01 0.228 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.940992e-01 0.226 0 0
MET activates RAS signaling R-HSA-8851805 5.940992e-01 0.226 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.940992e-01 0.226 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.940992e-01 0.226 0 0
Interleukin-35 Signalling R-HSA-8984722 5.940992e-01 0.226 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.940992e-01 0.226 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.940992e-01 0.226 0 0
Pervasive developmental disorders R-HSA-9005895 5.940992e-01 0.226 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.940992e-01 0.226 0 0
Disorders of Nervous System Development R-HSA-9697154 5.940992e-01 0.226 0 0
OAS antiviral response R-HSA-8983711 5.940992e-01 0.226 0 0
Interleukin-15 signaling R-HSA-8983432 5.940992e-01 0.226 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.987825e-01 0.223 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.991551e-01 0.222 0 0
Cellular responses to stress R-HSA-2262752 6.006053e-01 0.221 1 0
Oncogenic MAPK signaling R-HSA-6802957 6.008638e-01 0.221 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.017459e-01 0.221 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.017459e-01 0.221 0 0
Co-stimulation by CD28 R-HSA-389356 6.108815e-01 0.214 0 0
NGF-stimulated transcription R-HSA-9031628 6.108815e-01 0.214 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.117104e-01 0.213 1 1
Adenylate cyclase activating pathway R-HSA-170660 6.163518e-01 0.210 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.163518e-01 0.210 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.163518e-01 0.210 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.163518e-01 0.210 0 0
Chylomicron remodeling R-HSA-8963901 6.163518e-01 0.210 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.163518e-01 0.210 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.163518e-01 0.210 0 0
Processing of SMDT1 R-HSA-8949664 6.163518e-01 0.210 0 0
Maturation of nucleoprotein R-HSA-9683610 6.163518e-01 0.210 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.163518e-01 0.210 0 0
Trafficking of AMPA receptors R-HSA-399719 6.165822e-01 0.210 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.165822e-01 0.210 0 0
Cargo concentration in the ER R-HSA-5694530 6.165822e-01 0.210 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.184048e-01 0.209 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.199125e-01 0.208 0 0
DAG1 glycosylations R-HSA-8931838 6.309901e-01 0.200 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.309901e-01 0.200 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.368001e-01 0.196 0 0
Removal of the Flap Intermediate R-HSA-69166 6.373857e-01 0.196 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.373857e-01 0.196 0 0
cGMP effects R-HSA-418457 6.373857e-01 0.196 0 0
Malate-aspartate shuttle R-HSA-9856872 6.373857e-01 0.196 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.373857e-01 0.196 0 0
Regulation of KIT signaling R-HSA-1433559 6.373857e-01 0.196 0 0
P2Y receptors R-HSA-417957 6.373857e-01 0.196 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.373857e-01 0.196 0 0
Selective autophagy R-HSA-9663891 6.374648e-01 0.196 0 0
Diseases of programmed cell death R-HSA-9645723 6.374648e-01 0.196 0 0
Interleukin-17 signaling R-HSA-448424 6.399816e-01 0.194 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.449721e-01 0.190 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.449721e-01 0.190 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.449721e-01 0.190 0 0
Recycling of bile acids and salts R-HSA-159418 6.449721e-01 0.190 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.449721e-01 0.190 0 0
Integrin signaling R-HSA-354192 6.449721e-01 0.190 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.456887e-01 0.190 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.497526e-01 0.187 0 0
DNA Repair R-HSA-73894 6.506657e-01 0.187 0 0
PTEN Regulation R-HSA-6807070 6.516026e-01 0.186 0 0
Base Excision Repair R-HSA-73884 6.549678e-01 0.184 0 0
Orc1 removal from chromatin R-HSA-68949 6.567888e-01 0.183 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.567888e-01 0.183 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.567888e-01 0.183 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.572675e-01 0.182 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.572675e-01 0.182 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.572675e-01 0.182 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.572675e-01 0.182 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.572675e-01 0.182 0 0
Biotin transport and metabolism R-HSA-196780 6.572675e-01 0.182 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.572675e-01 0.182 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.572675e-01 0.182 0 0
p38MAPK events R-HSA-171007 6.572675e-01 0.182 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.572675e-01 0.182 0 0
Protein methylation R-HSA-8876725 6.572675e-01 0.182 0 0
Axon guidance R-HSA-422475 6.576218e-01 0.182 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.676365e-01 0.175 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.676365e-01 0.175 0 0
Meiotic synapsis R-HSA-1221632 6.676365e-01 0.175 0 0
Nucleotide biosynthesis R-HSA-8956320 6.676365e-01 0.175 0 0
Smooth Muscle Contraction R-HSA-445355 6.676365e-01 0.175 0 0
Dual Incision in GG-NER R-HSA-5696400 6.716724e-01 0.173 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.716724e-01 0.173 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.716724e-01 0.173 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.716724e-01 0.173 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.719211e-01 0.173 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.760604e-01 0.170 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.760604e-01 0.170 0 0
Differentiation of T cells R-HSA-9945266 6.760604e-01 0.170 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.760604e-01 0.170 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.760604e-01 0.170 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.760604e-01 0.170 0 0
Mineralocorticoid biosynthesis R-HSA-193993 6.760604e-01 0.170 0 0
Signaling by FGFR in disease R-HSA-1226099 6.779933e-01 0.169 0 0
Translation initiation complex formation R-HSA-72649 6.782315e-01 0.169 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.844002e-01 0.165 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.870462e-01 0.163 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.870462e-01 0.163 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.885743e-01 0.162 0 0
HDACs deacetylate histones R-HSA-3214815 6.885743e-01 0.162 0 0
Fibronectin matrix formation R-HSA-1566977 6.938239e-01 0.159 0 0
Synthesis of PG R-HSA-1483148 6.938239e-01 0.159 0 0
UCH proteinases R-HSA-5689603 6.959179e-01 0.157 0 0
GPVI-mediated activation cascade R-HSA-114604 6.967205e-01 0.157 0 0
FLT3 signaling in disease R-HSA-9682385 6.967205e-01 0.157 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.986656e-01 0.156 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.986656e-01 0.156 0 0
Signaling by FGFR1 R-HSA-5654736 6.986656e-01 0.156 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.986656e-01 0.156 0 0
Cellular responses to stimuli R-HSA-8953897 6.990693e-01 0.155 1 0
Signaling by NOTCH R-HSA-157118 7.038035e-01 0.153 0 0
Signaling by ROBO receptors R-HSA-376176 7.049824e-01 0.152 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.054525e-01 0.152 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.086399e-01 0.150 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 7.086399e-01 0.150 0 0
Collagen chain trimerization R-HSA-8948216 7.086399e-01 0.150 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.106144e-01 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.106144e-01 0.148 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.106144e-01 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.106144e-01 0.148 0 0
Catecholamine biosynthesis R-HSA-209905 7.106144e-01 0.148 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.106144e-01 0.148 0 0
Glycogen storage diseases R-HSA-3229121 7.106144e-01 0.148 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.106144e-01 0.148 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.125234e-01 0.147 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.131173e-01 0.147 0 0
Dual incision in TC-NER R-HSA-6782135 7.180991e-01 0.144 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.180991e-01 0.144 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.201651e-01 0.143 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.263134e-01 0.139 0 0
GAB1 signalosome R-HSA-180292 7.264850e-01 0.139 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.264850e-01 0.139 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.264850e-01 0.139 0 0
PKA activation in glucagon signalling R-HSA-164378 7.264850e-01 0.139 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.264850e-01 0.139 0 0
PKA activation R-HSA-163615 7.264850e-01 0.139 0 0
Mismatch Repair R-HSA-5358508 7.264850e-01 0.139 0 0
Tie2 Signaling R-HSA-210993 7.264850e-01 0.139 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.264850e-01 0.139 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.264850e-01 0.139 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.264850e-01 0.139 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.264850e-01 0.139 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.264850e-01 0.139 0 0
Telomere Maintenance R-HSA-157579 7.268235e-01 0.139 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.271360e-01 0.138 0 0
Triglyceride metabolism R-HSA-8979227 7.274448e-01 0.138 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.313036e-01 0.136 0 0
Signaling by FGFR R-HSA-190236 7.340984e-01 0.134 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.340984e-01 0.134 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.340984e-01 0.134 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.340984e-01 0.134 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.346646e-01 0.134 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.365255e-01 0.133 0 0
Kinesins R-HSA-983189 7.365458e-01 0.133 0 0
Cilium Assembly R-HSA-5617833 7.387851e-01 0.131 0 0
FOXO-mediated transcription R-HSA-9614085 7.412315e-01 0.130 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.414862e-01 0.130 0 0
Translesion Synthesis by POLH R-HSA-110320 7.414862e-01 0.130 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.414862e-01 0.130 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.414862e-01 0.130 0 0
Diseases of hemostasis R-HSA-9671793 7.414862e-01 0.130 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.414862e-01 0.130 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.414862e-01 0.130 0 0
HDL remodeling R-HSA-8964058 7.414862e-01 0.130 0 0
Maturation of nucleoprotein R-HSA-9694631 7.414862e-01 0.130 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.414862e-01 0.130 0 0
Other interleukin signaling R-HSA-449836 7.414862e-01 0.130 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.414862e-01 0.130 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.420630e-01 0.130 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.420630e-01 0.130 0 0
Attenuation phase R-HSA-3371568 7.420630e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.420630e-01 0.130 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.420630e-01 0.130 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.422450e-01 0.129 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.453509e-01 0.128 1 1
Regulation of RUNX2 expression and activity R-HSA-8939902 7.454047e-01 0.128 0 0
Nucleotide salvage R-HSA-8956321 7.454047e-01 0.128 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.524515e-01 0.124 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.524515e-01 0.124 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.556655e-01 0.122 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.556655e-01 0.122 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.556655e-01 0.122 0 0
Creatine metabolism R-HSA-71288 7.556655e-01 0.122 0 0
Formation of definitive endoderm R-HSA-9823730 7.556655e-01 0.122 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.556655e-01 0.122 0 0
Glycogen synthesis R-HSA-3322077 7.556655e-01 0.122 0 0
Signal transduction by L1 R-HSA-445144 7.556655e-01 0.122 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.559405e-01 0.122 0 0
PPARA activates gene expression R-HSA-1989781 7.572877e-01 0.121 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.606876e-01 0.119 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.624074e-01 0.118 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.624074e-01 0.118 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.624074e-01 0.118 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.624774e-01 0.118 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.624774e-01 0.118 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.624774e-01 0.118 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.624774e-01 0.118 0 0
Heme biosynthesis R-HSA-189451 7.624774e-01 0.118 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.631959e-01 0.117 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.680739e-01 0.115 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.690678e-01 0.114 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.690678e-01 0.114 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.690678e-01 0.114 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.690678e-01 0.114 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.690678e-01 0.114 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.690678e-01 0.114 0 0
Basigin interactions R-HSA-210991 7.690678e-01 0.114 0 0
Adaptive Immune System R-HSA-1280218 7.700166e-01 0.113 0 0
Activation of GABAB receptors R-HSA-991365 7.721491e-01 0.112 0 0
GABA B receptor activation R-HSA-977444 7.721491e-01 0.112 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.721491e-01 0.112 0 0
Depyrimidination R-HSA-73928 7.721491e-01 0.112 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.747870e-01 0.111 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.747870e-01 0.111 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.747870e-01 0.111 0 0
Cellular response to hypoxia R-HSA-1234174 7.784773e-01 0.109 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.817358e-01 0.107 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.817358e-01 0.107 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.817358e-01 0.107 0 0
Androgen biosynthesis R-HSA-193048 7.817358e-01 0.107 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.874910e-01 0.104 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.904649e-01 0.102 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 7.936420e-01 0.100 0 0
Kidney development R-HSA-9830369 7.936420e-01 0.100 0 0
Notch-HLH transcription pathway R-HSA-350054 7.937096e-01 0.100 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.937096e-01 0.100 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 7.937096e-01 0.100 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.937096e-01 0.100 0 0
Signaling by KIT in disease R-HSA-9669938 7.937096e-01 0.100 0 0
LDL clearance R-HSA-8964038 7.937096e-01 0.100 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.937096e-01 0.100 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.949889e-01 0.100 0 0
Peptide chain elongation R-HSA-156902 7.949889e-01 0.100 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.991266e-01 0.097 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.991266e-01 0.097 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 7.991266e-01 0.097 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.008942e-01 0.096 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.049058e-01 0.094 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.049058e-01 0.094 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.049058e-01 0.094 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.050271e-01 0.094 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.050271e-01 0.094 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.050271e-01 0.094 0 0
Formation of the ureteric bud R-HSA-9830674 8.050271e-01 0.094 0 0
Syndecan interactions R-HSA-3000170 8.050271e-01 0.094 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.074694e-01 0.093 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.074694e-01 0.093 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.074694e-01 0.093 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.074694e-01 0.093 0 0
Signaling by RAS mutants R-HSA-6802949 8.074694e-01 0.093 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.074694e-01 0.093 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.105299e-01 0.091 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.137412e-01 0.090 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.147577e-01 0.089 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.147577e-01 0.089 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.155022e-01 0.089 0 0
Recycling pathway of L1 R-HSA-437239 8.155022e-01 0.089 0 0
Synthesis of PC R-HSA-1483191 8.155022e-01 0.089 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.157245e-01 0.088 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.157245e-01 0.088 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.157245e-01 0.088 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.157245e-01 0.088 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.157245e-01 0.088 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.157245e-01 0.088 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.157245e-01 0.088 0 0
SLC transporter disorders R-HSA-5619102 8.168235e-01 0.088 0 0
ECM proteoglycans R-HSA-3000178 8.213771e-01 0.085 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.213771e-01 0.085 0 0
Metabolism of porphyrins R-HSA-189445 8.213771e-01 0.085 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.230845e-01 0.085 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.232338e-01 0.084 0 0
Metal ion SLC transporters R-HSA-425410 8.232338e-01 0.084 0 0
Cellular response to chemical stress R-HSA-9711123 8.235044e-01 0.084 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.246618e-01 0.084 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.254450e-01 0.083 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.254450e-01 0.083 0 0
G protein gated Potassium channels R-HSA-1296059 8.258355e-01 0.083 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.258355e-01 0.083 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.258355e-01 0.083 0 0
Laminin interactions R-HSA-3000157 8.258355e-01 0.083 0 0
Tight junction interactions R-HSA-420029 8.258355e-01 0.083 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.258355e-01 0.083 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 8.258355e-01 0.083 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.258355e-01 0.083 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.258355e-01 0.083 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.258355e-01 0.083 0 0
Ion channel transport R-HSA-983712 8.271730e-01 0.082 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.277938e-01 0.082 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.286055e-01 0.082 0 0
DNA Damage Bypass R-HSA-73893 8.306731e-01 0.081 0 0
Degradation of CDH1 R-HSA-9766229 8.306731e-01 0.081 0 0
tRNA processing R-HSA-72306 8.339719e-01 0.079 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.340121e-01 0.079 0 0
Toll-like Receptor Cascades R-HSA-168898 8.351314e-01 0.078 0 0
TRP channels R-HSA-3295583 8.353923e-01 0.078 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 8.353923e-01 0.078 0 0
Urea cycle R-HSA-70635 8.353923e-01 0.078 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.353923e-01 0.078 0 0
Sphingolipid catabolism R-HSA-9845614 8.353923e-01 0.078 0 0
Azathioprine ADME R-HSA-9748787 8.378290e-01 0.077 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.418527e-01 0.075 0 0
Packaging Of Telomere Ends R-HSA-171306 8.444253e-01 0.073 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.444253e-01 0.073 0 0
Cristae formation R-HSA-8949613 8.444253e-01 0.073 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.444253e-01 0.073 0 0
Signaling by BMP R-HSA-201451 8.444253e-01 0.073 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.444253e-01 0.073 0 0
Insulin processing R-HSA-264876 8.444253e-01 0.073 0 0
Meiotic recombination R-HSA-912446 8.447100e-01 0.073 1 1
Non-integrin membrane-ECM interactions R-HSA-3000171 8.458703e-01 0.073 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.470260e-01 0.072 0 0
Eukaryotic Translation Termination R-HSA-72764 8.470260e-01 0.072 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.509790e-01 0.070 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.513248e-01 0.070 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.513248e-01 0.070 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.520557e-01 0.070 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.529631e-01 0.069 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.529631e-01 0.069 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.554926e-01 0.068 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.554926e-01 0.068 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.576818e-01 0.067 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.576818e-01 0.067 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.610328e-01 0.065 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.610328e-01 0.065 0 0
Thyroxine biosynthesis R-HSA-209968 8.610328e-01 0.065 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.610328e-01 0.065 0 0
Platelet calcium homeostasis R-HSA-418360 8.610328e-01 0.065 0 0
DARPP-32 events R-HSA-180024 8.610328e-01 0.065 0 0
PCP/CE pathway R-HSA-4086400 8.622764e-01 0.064 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.622764e-01 0.064 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.637895e-01 0.064 0 0
Cellular response to starvation R-HSA-9711097 8.656890e-01 0.063 0 0
Sensory processing of sound R-HSA-9659379 8.673940e-01 0.062 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.683541e-01 0.061 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.683541e-01 0.061 0 0
DAP12 signaling R-HSA-2424491 8.686601e-01 0.061 0 0
Neurotransmitter clearance R-HSA-112311 8.686601e-01 0.061 0 0
Selenocysteine synthesis R-HSA-2408557 8.751452e-01 0.058 0 0
Metabolism of amine-derived hormones R-HSA-209776 8.752894e-01 0.058 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.758692e-01 0.058 0 0
Downstream signal transduction R-HSA-186763 8.758692e-01 0.058 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.758692e-01 0.058 0 0
Amyloid fiber formation R-HSA-977225 8.771284e-01 0.057 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.802363e-01 0.055 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.802363e-01 0.055 0 0
Regulation of CDH1 Function R-HSA-9764561 8.806976e-01 0.055 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.826830e-01 0.054 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.826830e-01 0.054 0 0
Viral mRNA Translation R-HSA-192823 8.834708e-01 0.054 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.858884e-01 0.053 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.862233e-01 0.052 0 0
Membrane Trafficking R-HSA-199991 8.864858e-01 0.052 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.891232e-01 0.051 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.891232e-01 0.051 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.905415e-01 0.050 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.908692e-01 0.050 0 0
Extension of Telomeres R-HSA-180786 8.908692e-01 0.050 0 0
Peroxisomal protein import R-HSA-9033241 8.908692e-01 0.050 0 0
Signaling by VEGF R-HSA-194138 8.946465e-01 0.048 0 0
Meiosis R-HSA-1500620 8.947123e-01 0.048 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.950523e-01 0.048 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.952102e-01 0.048 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.952102e-01 0.048 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.952102e-01 0.048 0 0
Heme degradation R-HSA-189483 8.952102e-01 0.048 0 0
Glutamate and glutamine metabolism R-HSA-8964539 8.952102e-01 0.048 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.952102e-01 0.048 0 0
GABA receptor activation R-HSA-977443 8.956475e-01 0.048 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.987398e-01 0.046 0 0
Aquaporin-mediated transport R-HSA-445717 9.002305e-01 0.046 0 0
Endogenous sterols R-HSA-211976 9.002305e-01 0.046 0 0
Signaling by NOTCH2 R-HSA-1980145 9.009634e-01 0.045 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.009634e-01 0.045 0 0
Mitophagy R-HSA-5205647 9.009634e-01 0.045 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.009634e-01 0.045 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.021827e-01 0.045 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.022003e-01 0.045 0 0
Mitochondrial protein import R-HSA-1268020 9.046252e-01 0.044 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.046252e-01 0.044 0 0
Interleukin-12 family signaling R-HSA-447115 9.063810e-01 0.043 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.064011e-01 0.043 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.064011e-01 0.043 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.064011e-01 0.043 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.068000e-01 0.042 0 0
Complex I biogenesis R-HSA-6799198 9.088385e-01 0.042 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.115405e-01 0.040 0 0
HSF1 activation R-HSA-3371511 9.115405e-01 0.040 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.115405e-01 0.040 0 0
Calmodulin induced events R-HSA-111933 9.115405e-01 0.040 0 0
CaM pathway R-HSA-111997 9.115405e-01 0.040 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.121161e-01 0.040 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.121161e-01 0.040 0 0
Ion transport by P-type ATPases R-HSA-936837 9.128770e-01 0.040 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.128770e-01 0.040 0 0
Transmission across Chemical Synapses R-HSA-112315 9.153989e-01 0.038 0 0
Degradation of AXIN R-HSA-4641257 9.163980e-01 0.038 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.163980e-01 0.038 0 0
Voltage gated Potassium channels R-HSA-1296072 9.163980e-01 0.038 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.163980e-01 0.038 0 0
Cleavage of the damaged purine R-HSA-110331 9.163980e-01 0.038 0 0
NCAM1 interactions R-HSA-419037 9.163980e-01 0.038 0 0
Ovarian tumor domain proteases R-HSA-5689896 9.163980e-01 0.038 0 0
Metabolism of folate and pterines R-HSA-196757 9.163980e-01 0.038 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.167473e-01 0.038 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.167473e-01 0.038 0 0
Neurotransmitter release cycle R-HSA-112310 9.168667e-01 0.038 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.168667e-01 0.038 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.190221e-01 0.037 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.195996e-01 0.036 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.201168e-01 0.036 0 0
Depurination R-HSA-73927 9.209891e-01 0.036 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.209891e-01 0.036 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.209891e-01 0.036 0 0
Biofilm formation R-HSA-9931953 9.209891e-01 0.036 0 0
Purine salvage R-HSA-74217 9.209891e-01 0.036 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.209891e-01 0.036 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.211267e-01 0.036 0 0
Nicotinate metabolism R-HSA-196807 9.240079e-01 0.034 0 0
Neddylation R-HSA-8951664 9.252707e-01 0.034 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.253283e-01 0.034 0 0
EPH-Ephrin signaling R-HSA-2682334 9.262711e-01 0.033 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.274103e-01 0.033 0 0
Regulated Necrosis R-HSA-5218859 9.274103e-01 0.033 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.294294e-01 0.032 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.294294e-01 0.032 0 0
Glycogen metabolism R-HSA-8982491 9.294294e-01 0.032 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.294294e-01 0.032 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.306685e-01 0.031 0 0
FLT3 Signaling R-HSA-9607240 9.333055e-01 0.030 0 0
COPII-mediated vesicle transport R-HSA-204005 9.337881e-01 0.030 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.337881e-01 0.030 0 0
Ribosome-associated quality control R-HSA-9948299 9.361199e-01 0.029 0 0
Signaling by Hedgehog R-HSA-5358351 9.361199e-01 0.029 0 0
Rab regulation of trafficking R-HSA-9007101 9.367012e-01 0.028 0 0
Hedgehog 'on' state R-HSA-5632684 9.367744e-01 0.028 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.367744e-01 0.028 0 0
MAP2K and MAPK activation R-HSA-5674135 9.369690e-01 0.028 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.369690e-01 0.028 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.369690e-01 0.028 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.369690e-01 0.028 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.369690e-01 0.028 0 0
Intra-Golgi traffic R-HSA-6811438 9.369690e-01 0.028 0 0
Translation of Structural Proteins R-HSA-9683701 9.369690e-01 0.028 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.372940e-01 0.028 0 0
Potassium Channels R-HSA-1296071 9.398012e-01 0.027 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.398012e-01 0.027 0 0
Phospholipid metabolism R-HSA-1483257 9.402573e-01 0.027 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.404314e-01 0.027 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.404314e-01 0.027 0 0
Ca-dependent events R-HSA-111996 9.404314e-01 0.027 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.437038e-01 0.025 0 0
Signaling by SCF-KIT R-HSA-1433557 9.437038e-01 0.025 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.437038e-01 0.025 0 0
Interferon Signaling R-HSA-913531 9.448750e-01 0.025 0 0
rRNA processing R-HSA-72312 9.449625e-01 0.025 0 0
Signaling by NOTCH4 R-HSA-9013694 9.449852e-01 0.025 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.467765e-01 0.024 0 0
DAP12 interactions R-HSA-2172127 9.467967e-01 0.024 0 0
Gap junction trafficking R-HSA-190828 9.467967e-01 0.024 0 0
RMTs methylate histone arginines R-HSA-3214858 9.467967e-01 0.024 1 1
Methylation R-HSA-156581 9.467967e-01 0.024 0 0
Surfactant metabolism R-HSA-5683826 9.467967e-01 0.024 0 0
Protein ubiquitination R-HSA-8852135 9.474890e-01 0.023 0 0
Iron uptake and transport R-HSA-917937 9.474890e-01 0.023 0 0
Hedgehog 'off' state R-HSA-5610787 9.489294e-01 0.023 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.497198e-01 0.022 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.497198e-01 0.022 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.497198e-01 0.022 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.497198e-01 0.022 0 0
DAG and IP3 signaling R-HSA-1489509 9.497198e-01 0.022 0 0
Interleukin-12 signaling R-HSA-9020591 9.498840e-01 0.022 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.524825e-01 0.021 0 0
Cholesterol biosynthesis R-HSA-191273 9.543648e-01 0.020 0 0
Interleukin-10 signaling R-HSA-6783783 9.543648e-01 0.020 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.550935e-01 0.020 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.550935e-01 0.020 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.564591e-01 0.019 0 0
GPER1 signaling R-HSA-9634597 9.575612e-01 0.019 0 0
Intraflagellar transport R-HSA-5620924 9.575612e-01 0.019 0 0
RSV-host interactions R-HSA-9833110 9.585279e-01 0.018 0 0
Viral Infection Pathways R-HSA-9824446 9.588472e-01 0.018 0 0
Gap junction trafficking and regulation R-HSA-157858 9.598934e-01 0.018 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.598934e-01 0.018 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.598934e-01 0.018 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.620976e-01 0.017 0 0
Protein localization R-HSA-9609507 9.636574e-01 0.016 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.641808e-01 0.016 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.644121e-01 0.016 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.652838e-01 0.015 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.656214e-01 0.015 0 0
Neuronal System R-HSA-112316 9.660558e-01 0.015 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.661497e-01 0.015 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.678120e-01 0.014 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.701966e-01 0.013 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.701966e-01 0.013 0 0
G alpha (z) signalling events R-HSA-418597 9.714309e-01 0.013 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.714309e-01 0.013 0 0
Pyruvate metabolism R-HSA-70268 9.715869e-01 0.013 0 0
Signaling by Interleukins R-HSA-449147 9.722963e-01 0.012 0 0
Integration of energy metabolism R-HSA-163685 9.727649e-01 0.012 0 0
Ion homeostasis R-HSA-5578775 9.730016e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.744860e-01 0.011 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.772147e-01 0.010 0 0
IRE1alpha activates chaperones R-HSA-381070 9.776503e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.781388e-01 0.010 0 0
RAB geranylgeranylation R-HSA-8873719 9.784678e-01 0.009 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.784678e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.787027e-01 0.009 0 0
PLC beta mediated events R-HSA-112043 9.796519e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.806655e-01 0.008 0 0
Mitochondrial protein degradation R-HSA-9837999 9.806655e-01 0.008 0 0
Signaling by PDGF R-HSA-186797 9.807710e-01 0.008 0 0
Semaphorin interactions R-HSA-373755 9.818287e-01 0.008 0 0
Gastrulation R-HSA-9758941 9.844821e-01 0.007 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.845775e-01 0.007 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.846655e-01 0.007 0 0
Regulation of insulin secretion R-HSA-422356 9.848357e-01 0.007 0 0
Potential therapeutics for SARS R-HSA-9679191 9.851033e-01 0.007 0 0
G-protein mediated events R-HSA-112040 9.855091e-01 0.006 0 0
Metabolism of steroid hormones R-HSA-196071 9.855091e-01 0.006 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.855091e-01 0.006 0 0
Metabolism of steroids R-HSA-8957322 9.857191e-01 0.006 0 0
Platelet degranulation R-HSA-114608 9.865092e-01 0.006 0 0
Developmental Biology R-HSA-1266738 9.866623e-01 0.006 1 0
Vesicle-mediated transport R-HSA-5653656 9.870184e-01 0.006 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.877719e-01 0.005 0 0
SARS-CoV Infections R-HSA-9679506 9.879713e-01 0.005 0 0
Retinoid metabolism and transport R-HSA-975634 9.884448e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.884448e-01 0.005 0 0
Opioid Signalling R-HSA-111885 9.886950e-01 0.005 0 0
Reproduction R-HSA-1474165 9.887086e-01 0.005 1 0
Sensory perception of taste R-HSA-9717189 9.892020e-01 0.005 0 0
Cardiac conduction R-HSA-5576891 9.892020e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.896816e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.897251e-01 0.004 0 0
Muscle contraction R-HSA-397014 9.901145e-01 0.004 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.901274e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.902471e-01 0.004 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.902471e-01 0.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.907739e-01 0.004 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.907862e-01 0.004 0 0
Selenoamino acid metabolism R-HSA-2408522 9.916641e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 9.917727e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.922256e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.922256e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.927523e-01 0.003 0 0
PKR-mediated signaling R-HSA-9833482 9.930581e-01 0.003 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.934262e-01 0.003 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.934404e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.943492e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.943492e-01 0.002 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.947721e-01 0.002 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.950583e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.955878e-01 0.002 0 0
Metabolism of nucleotides R-HSA-15869 9.960462e-01 0.002 0 0
Downstream TCR signaling R-HSA-202424 9.962776e-01 0.002 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.964840e-01 0.002 0 0
Protein folding R-HSA-391251 9.968596e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.970327e-01 0.001 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.973508e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.974051e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.976348e-01 0.001 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.976348e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.981148e-01 0.001 0 0
Interleukin-1 signaling R-HSA-9020702 9.982187e-01 0.001 0 0
O-linked glycosylation R-HSA-5173105 9.983999e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.985132e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.985284e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.985552e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.986271e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.986271e-01 0.001 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.986271e-01 0.001 0 0
Respiratory electron transport R-HSA-611105 9.989336e-01 0.000 0 0
TCR signaling R-HSA-202403 9.989900e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.990457e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.991736e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.991994e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.992190e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.992396e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.992955e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.993212e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.994832e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.995172e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.995691e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.995857e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996567e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.996759e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.996803e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.996999e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997749e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997749e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999123e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999151e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999152e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999247e-01 0.000 0 0
Disease R-HSA-1643685 9.999300e-01 0.000 1 0
Interleukin-1 family signaling R-HSA-446652 9.999340e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999436e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999443e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999452e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999483e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999513e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999622e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999622e-01 0.000 0 0
Immune System R-HSA-168256 9.999785e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.999789e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999801e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999803e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999826e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999940e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999952e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999956e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999959e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999966e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999977e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.999982e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999988e-01 0.000 0 0
Translation R-HSA-72766 9.999992e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999992e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999992e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999998e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999998e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.000000e+00 0.000 1 1
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.000000e+00 0.000 1 1
PTK6 Regulates Cell Cycle R-HSA-8849470 1.000000e+00 0.000 1 1
Diseases of Cellular Senescence R-HSA-9630747 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.000000e+00 0.000 1 1
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.000000e+00 0.000 1 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.000000e+00 0.000 1 1
Diseases of cellular response to stress R-HSA-9675132 1.000000e+00 0.000 1 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.909584e-14 13.719 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.565414e-14 13.805 0 0
Attenuation phase R-HSA-3371568 1.285871e-11 10.891 0 0
HSF1-dependent transactivation R-HSA-3371571 2.269961e-10 9.644 0 0
HSF1 activation R-HSA-3371511 8.577048e-08 7.067 0 0
Cell Cycle, Mitotic R-HSA-69278 7.993690e-08 7.097 1 0
Chromatin organization R-HSA-4839726 7.125573e-08 7.147 1 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.692571e-07 6.245 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.996471e-07 6.155 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.880177e-07 6.103 0 0
Chromatin modifying enzymes R-HSA-3247509 9.176189e-07 6.037 1 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.046969e-06 5.980 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.392970e-06 5.856 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.336286e-06 5.874 0 0
Cell Cycle R-HSA-1640170 1.554885e-06 5.808 1 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.169658e-06 5.287 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.009416e-06 5.154 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.009416e-06 5.154 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.593664e-06 5.181 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.250464e-05 4.903 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.646968e-05 4.783 0 0
Nuclear import of Rev protein R-HSA-180746 2.150374e-05 4.667 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.928750e-05 4.533 0 0
RUNX2 regulates bone development R-HSA-8941326 3.577150e-05 4.446 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.367538e-05 4.360 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.561007e-05 4.341 0 0
Cellular responses to stress R-HSA-2262752 5.857919e-05 4.232 1 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.773775e-05 4.239 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.258935e-05 4.139 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.201659e-05 4.086 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.066281e-05 4.043 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.066281e-05 4.043 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.105271e-04 3.957 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.125252e-04 3.949 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.178180e-04 3.929 0 0
M Phase R-HSA-68886 1.871483e-04 3.728 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.099562e-04 3.678 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.624211e-04 3.581 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.041391e-04 3.517 0 0
Circadian clock R-HSA-9909396 3.537312e-04 3.451 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.119706e-04 3.385 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.046236e-04 3.393 0 0
Mitotic Prophase R-HSA-68875 4.176278e-04 3.379 0 0
TGFBR3 expression R-HSA-9839394 4.808409e-04 3.318 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.837502e-04 3.315 0 0
Cellular responses to stimuli R-HSA-8953897 4.925269e-04 3.308 1 0
G1/S-Specific Transcription R-HSA-69205 4.965500e-04 3.304 0 0
Heme signaling R-HSA-9707616 5.627601e-04 3.250 0 0
tRNA processing in the nucleus R-HSA-6784531 5.627601e-04 3.250 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.608794e-04 3.119 1 0
Amplification of signal from the kinetochores R-HSA-141424 7.855471e-04 3.105 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.855471e-04 3.105 0 0
Formation of axial mesoderm R-HSA-9796292 8.360416e-04 3.078 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.516353e-04 3.070 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.627518e-04 3.016 0 0
Metabolism of non-coding RNA R-HSA-194441 1.009464e-03 2.996 0 0
snRNP Assembly R-HSA-191859 1.009464e-03 2.996 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.103191e-03 2.957 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.094599e-03 2.961 0 0
Gene expression (Transcription) R-HSA-74160 1.086385e-03 2.964 1 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.158541e-03 2.936 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.261843e-03 2.899 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.256393e-03 2.901 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.267123e-03 2.897 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.462258e-03 2.835 1 1
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.514959e-03 2.820 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.560367e-03 2.807 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.571253e-03 2.804 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.801208e-03 2.744 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.801208e-03 2.744 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.849446e-03 2.733 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.849446e-03 2.733 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.158324e-03 2.666 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.695574e-03 2.569 0 0
mRNA 3'-end processing R-HSA-72187 2.792104e-03 2.554 0 0
Adipogenesis R-HSA-9843745 3.038752e-03 2.517 1 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.502227e-03 2.456 0 0
Signaling by Hippo R-HSA-2028269 3.516624e-03 2.454 0 0
Mitotic Anaphase R-HSA-68882 3.606710e-03 2.443 0 0
HIV Life Cycle R-HSA-162587 3.714891e-03 2.430 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.841086e-03 2.416 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.100019e-03 2.387 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.100019e-03 2.387 0 0
NGF-stimulated transcription R-HSA-9031628 4.330278e-03 2.363 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.876061e-03 2.312 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.376535e-03 2.269 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.376535e-03 2.269 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 5.382878e-03 2.269 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.602125e-03 2.252 0 0
Cellular Senescence R-HSA-2559583 5.846780e-03 2.233 1 0
Separation of Sister Chromatids R-HSA-2467813 6.113525e-03 2.214 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.325874e-03 2.199 0 0
HDMs demethylate histones R-HSA-3214842 6.443689e-03 2.191 0 0
G1/S Transition R-HSA-69206 6.732557e-03 2.172 1 0
G0 and Early G1 R-HSA-1538133 6.827980e-03 2.166 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.827980e-03 2.166 1 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.714290e-03 2.113 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.871010e-03 2.104 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.581052e-03 2.120 1 1
Mitotic Prometaphase R-HSA-68877 7.558129e-03 2.122 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.360243e-03 2.078 0 0
Cell Cycle Checkpoints R-HSA-69620 8.366358e-03 2.077 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.461833e-03 2.073 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.575632e-03 2.067 0 0
Apoptotic execution phase R-HSA-75153 8.750508e-03 2.058 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.765657e-03 2.057 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.854629e-03 2.053 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.574272e-03 2.019 1 1
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.701202e-03 2.013 0 0
Gene Silencing by RNA R-HSA-211000 9.607363e-03 2.017 0 0
NRAGE signals death through JNK R-HSA-193648 1.165016e-02 1.934 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.185008e-02 1.926 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.191359e-02 1.924 0 0
Notch-HLH transcription pathway R-HSA-350054 1.227609e-02 1.911 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.284858e-02 1.891 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.305479e-02 1.884 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.312205e-02 1.882 0 0
Signal Transduction R-HSA-162582 1.347304e-02 1.871 1 0
Inositol phosphate metabolism R-HSA-1483249 1.418188e-02 1.848 0 0
Activation of the pre-replicative complex R-HSA-68962 1.473680e-02 1.832 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.473680e-02 1.832 1 0
Regulation of TP53 Activity R-HSA-5633007 1.496448e-02 1.825 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.599955e-02 1.796 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.599955e-02 1.796 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.631196e-02 1.787 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.632934e-02 1.787 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.632934e-02 1.787 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.740292e-02 1.759 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.778077e-02 1.750 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.823717e-02 1.739 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.100257e-02 1.678 0 0
Unwinding of DNA R-HSA-176974 2.160994e-02 1.665 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.167254e-02 1.664 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.167254e-02 1.664 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.167254e-02 1.664 0 0
Signaling by RAS mutants R-HSA-6802949 2.167254e-02 1.664 0 0
Signaling by TGFBR3 R-HSA-9839373 2.167254e-02 1.664 0 0
S Phase R-HSA-69242 2.172767e-02 1.663 1 0
Myogenesis R-HSA-525793 2.340399e-02 1.631 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.385363e-02 1.622 0 0
IRS activation R-HSA-74713 2.385363e-02 1.622 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.385363e-02 1.622 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.444181e-02 1.612 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.643150e-02 1.578 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.751869e-02 1.560 0 0
Signal attenuation R-HSA-74749 2.784818e-02 1.555 0 0
Josephin domain DUBs R-HSA-5689877 2.784818e-02 1.555 0 0
RAF activation R-HSA-5673000 2.892076e-02 1.539 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.929420e-02 1.533 0 0
HIV Infection R-HSA-162906 2.957392e-02 1.529 0 0
MAP2K and MAPK activation R-HSA-5674135 2.970883e-02 1.527 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.970883e-02 1.527 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.983980e-02 1.525 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.991244e-02 1.524 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.188713e-02 1.496 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.188713e-02 1.496 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.214523e-02 1.493 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.344028e-02 1.476 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.344028e-02 1.476 0 0
RET signaling R-HSA-8853659 3.659539e-02 1.437 0 0
Glycolysis R-HSA-70171 3.671023e-02 1.435 0 0
Signaling by NTRKs R-HSA-166520 3.673781e-02 1.435 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.685495e-02 1.434 0 0
mTORC1-mediated signalling R-HSA-166208 3.742173e-02 1.427 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.324032e-02 1.364 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.799772e-02 1.420 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.799772e-02 1.420 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.799772e-02 1.420 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.799772e-02 1.420 0 0
Orc1 removal from chromatin R-HSA-68949 3.975399e-02 1.401 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.100738e-02 1.387 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.081058e-02 1.389 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.081058e-02 1.389 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.081058e-02 1.389 0 0
Activation of RAC1 R-HSA-428540 4.324032e-02 1.364 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.911250e-02 1.408 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.188617e-02 1.378 1 1
Deubiquitination R-HSA-5688426 4.270801e-02 1.369 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.305963e-02 1.366 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.402328e-02 1.356 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.477703e-02 1.349 0 0
RNA Polymerase II Transcription R-HSA-73857 4.646100e-02 1.333 1 0
Regulation of TP53 Expression R-HSA-6804754 4.797821e-02 1.319 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.797821e-02 1.319 0 0
Deadenylation of mRNA R-HSA-429947 4.920266e-02 1.308 0 0
Death Receptor Signaling R-HSA-73887 5.017019e-02 1.300 0 0
Signaling by ALK R-HSA-201556 5.049532e-02 1.297 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.223339e-02 1.282 0 0
Polo-like kinase mediated events R-HSA-156711 5.223339e-02 1.282 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.240978e-02 1.281 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.240978e-02 1.281 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.240978e-02 1.281 0 0
SOS-mediated signalling R-HSA-112412 5.766158e-02 1.239 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.766158e-02 1.239 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.766158e-02 1.239 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.036980e-02 1.219 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.579355e-02 1.253 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.616168e-02 1.251 0 0
HCMV Early Events R-HSA-9609690 6.118685e-02 1.213 0 0
Synthesis of DNA R-HSA-69239 6.050483e-02 1.218 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.766158e-02 1.239 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.050483e-02 1.218 0 0
Signaling by ALK in cancer R-HSA-9700206 6.050483e-02 1.218 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.661954e-02 1.247 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.661954e-02 1.247 0 0
Host Interactions of HIV factors R-HSA-162909 6.140697e-02 1.212 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.143269e-02 1.212 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.143269e-02 1.212 0 0
HATs acetylate histones R-HSA-3214847 6.144778e-02 1.211 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.144778e-02 1.211 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.255242e-02 1.204 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.255242e-02 1.204 1 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.255242e-02 1.204 1 1
Gastrulation R-HSA-9758941 6.272379e-02 1.203 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.296210e-02 1.201 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.302871e-02 1.200 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.302871e-02 1.200 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.444270e-02 1.191 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.741605e-02 1.171 0 0
HIV Transcription Initiation R-HSA-167161 6.741605e-02 1.171 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.741605e-02 1.171 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.741605e-02 1.171 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.780027e-02 1.169 0 0
MET interacts with TNS proteins R-HSA-8875513 7.089177e-02 1.149 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.214646e-02 1.142 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.214646e-02 1.142 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.214646e-02 1.142 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.866951e-02 1.104 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.042271e-02 1.095 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.701187e-02 1.113 0 0
Transcription of the HIV genome R-HSA-167172 7.197862e-02 1.143 0 0
Formation of definitive endoderm R-HSA-9823730 6.918418e-02 1.160 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.456396e-02 1.127 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.068840e-02 1.093 0 0
MTOR signalling R-HSA-165159 7.374576e-02 1.132 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.089177e-02 1.149 0 0
Oncogene Induced Senescence R-HSA-2559585 7.689346e-02 1.114 1 1
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.038626e-02 1.095 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.038626e-02 1.095 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.866951e-02 1.104 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.264501e-02 1.083 0 0
Sensory processing of sound R-HSA-9659379 8.182163e-02 1.087 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.214646e-02 1.142 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.619870e-02 1.118 0 0
Apoptosis R-HSA-109581 7.311375e-02 1.136 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.315680e-02 1.080 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.315680e-02 1.080 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.444158e-02 1.073 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.448220e-02 1.073 0 0
DCC mediated attractive signaling R-HSA-418885 8.566885e-02 1.067 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.566885e-02 1.067 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.643043e-02 1.063 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.643043e-02 1.063 0 0
Signaling by MET R-HSA-6806834 8.711704e-02 1.060 0 0
mRNA Splicing R-HSA-72172 8.772708e-02 1.057 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.807885e-02 1.055 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.807885e-02 1.055 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.807885e-02 1.055 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.872677e-02 1.052 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.115139e-02 1.040 0 0
PTEN Regulation R-HSA-6807070 9.264923e-02 1.033 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.481602e-02 1.023 0 0
Regulation of gap junction activity R-HSA-191650 9.657847e-02 1.015 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.657847e-02 1.015 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 9.657847e-02 1.015 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.657847e-02 1.015 0 0
Activation of BH3-only proteins R-HSA-114452 9.685376e-02 1.014 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.857698e-02 1.006 0 0
Prolonged ERK activation events R-HSA-169893 9.857698e-02 1.006 0 0
MET promotes cell motility R-HSA-8875878 1.008926e-01 0.996 0 0
Nervous system development R-HSA-9675108 1.009014e-01 0.996 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.244194e-01 0.905 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.244194e-01 0.905 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.244194e-01 0.905 0 0
G2 Phase R-HSA-68911 1.244194e-01 0.905 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.053395e-01 0.977 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.268765e-01 0.897 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.257232e-01 0.901 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.257232e-01 0.901 0 0
UCH proteinases R-HSA-5689603 1.200151e-01 0.921 0 0
DNA strand elongation R-HSA-69190 1.167627e-01 0.933 0 0
Aggrephagy R-HSA-9646399 1.189098e-01 0.925 0 0
HDACs deacetylate histones R-HSA-3214815 1.026504e-01 0.989 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.244194e-01 0.905 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.149569e-01 0.939 0 0
Signaling by NOTCH1 R-HSA-1980143 1.200151e-01 0.921 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.244194e-01 0.905 0 0
Membrane Trafficking R-HSA-199991 1.053010e-01 0.978 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.123293e-01 0.950 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.230268e-01 0.910 0 0
EGFR downregulation R-HSA-182971 1.065669e-01 0.972 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.189647e-01 0.925 0 0
Mitochondrial biogenesis R-HSA-1592230 1.129516e-01 0.947 0 0
Cell-Cell communication R-HSA-1500931 1.200315e-01 0.921 0 0
Signaling by EGFR R-HSA-177929 1.100529e-01 0.958 0 0
Signaling by ROBO receptors R-HSA-376176 1.177086e-01 0.929 0 0
Specification of primordial germ cells R-HSA-9827857 1.268765e-01 0.897 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.236383e-01 0.908 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.244194e-01 0.905 0 0
Glucose metabolism R-HSA-70326 1.129516e-01 0.947 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.270467e-01 0.896 0 0
Integrin signaling R-HSA-354192 1.274271e-01 0.895 0 0
Nuclear RNA decay R-HSA-9930044 1.274271e-01 0.895 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.274271e-01 0.895 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.274271e-01 0.895 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.285116e-01 0.891 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.306791e-01 0.884 0 0
Cell junction organization R-HSA-446728 1.332012e-01 0.875 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.343000e-01 0.872 0 0
G alpha (12/13) signalling events R-HSA-416482 1.343000e-01 0.872 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.385440e-01 0.858 0 0
Generic Transcription Pathway R-HSA-212436 1.414397e-01 0.849 1 0
Mitotic G2-G2/M phases R-HSA-453274 1.418376e-01 0.848 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.421651e-01 0.847 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.421651e-01 0.847 0 0
Adherens junctions interactions R-HSA-418990 1.424691e-01 0.846 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.425162e-01 0.846 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.594031e-01 0.798 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.594031e-01 0.798 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.594031e-01 0.798 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.594031e-01 0.798 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.594031e-01 0.798 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.594031e-01 0.798 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.538791e-01 0.813 0 0
Phosphorylation of Emi1 R-HSA-176417 1.538791e-01 0.813 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.538791e-01 0.813 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.844965e-01 0.734 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.433291e-01 0.844 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.433291e-01 0.844 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.433291e-01 0.844 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.637911e-01 0.786 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.581375e-01 0.801 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.581375e-01 0.801 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.623883e-01 0.789 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.623883e-01 0.789 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.765119e-01 0.753 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.765119e-01 0.753 0 0
HIV elongation arrest and recovery R-HSA-167287 1.765119e-01 0.753 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.765119e-01 0.753 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.500954e-01 0.824 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.557114e-01 0.808 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.656570e-01 0.781 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.758861e-01 0.755 0 0
Translation initiation complex formation R-HSA-72649 1.758861e-01 0.755 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.603842e-01 0.795 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.863873e-01 0.730 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.549351e-01 0.810 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.549351e-01 0.810 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.822628e-01 0.739 0 0
G1 Phase R-HSA-69236 1.704941e-01 0.768 1 0
Cyclin D associated events in G1 R-HSA-69231 1.704941e-01 0.768 1 1
Regulation of endogenous retroelements R-HSA-9842860 1.901028e-01 0.721 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.637911e-01 0.786 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.656570e-01 0.781 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.871536e-01 0.728 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.818315e-01 0.740 0 0
Formation of lateral plate mesoderm R-HSA-9758920 1.538791e-01 0.813 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.538791e-01 0.813 0 0
Interleukin-6 signaling R-HSA-1059683 1.850529e-01 0.733 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.494585e-01 0.825 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.549351e-01 0.810 0 0
Cellular response to hypoxia R-HSA-1234174 1.890699e-01 0.723 0 0
Frs2-mediated activation R-HSA-170968 1.850529e-01 0.733 0 0
Signaling by SCF-KIT R-HSA-1433557 1.594778e-01 0.797 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.634886e-01 0.787 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.433291e-01 0.844 0 0
Signaling by LTK R-HSA-9842663 1.637911e-01 0.786 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.850529e-01 0.733 0 0
TBC/RABGAPs R-HSA-8854214 1.594778e-01 0.797 0 0
Axon guidance R-HSA-422475 1.767570e-01 0.753 0 0
Metabolism of RNA R-HSA-8953854 1.642660e-01 0.784 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.538791e-01 0.813 0 0
Rab regulation of trafficking R-HSA-9007101 1.735782e-01 0.761 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.697032e-01 0.770 1 0
Signaling by PTK6 R-HSA-8848021 1.697032e-01 0.770 1 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.910797e-01 0.719 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.818315e-01 0.740 0 0
Programmed Cell Death R-HSA-5357801 1.809290e-01 0.742 0 0
Interleukin-15 signaling R-HSA-8983432 1.637911e-01 0.786 0 0
Influenza Infection R-HSA-168255 1.480038e-01 0.830 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.918927e-01 0.717 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 1.932766e-01 0.714 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.293127e-01 0.640 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.293127e-01 0.640 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.293127e-01 0.640 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.293127e-01 0.640 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.293127e-01 0.640 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.293127e-01 0.640 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.934121e-01 0.533 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.934121e-01 0.533 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.934121e-01 0.533 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 2.934121e-01 0.533 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 2.934121e-01 0.533 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 2.934121e-01 0.533 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.934121e-01 0.533 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.158755e-01 0.666 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.158755e-01 0.666 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.158755e-01 0.666 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 2.158755e-01 0.666 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.521836e-01 0.453 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 3.521836e-01 0.453 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.521836e-01 0.453 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.521836e-01 0.453 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 3.521836e-01 0.453 0 0
Invadopodia formation R-HSA-8941237 3.521836e-01 0.453 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 3.521836e-01 0.453 0 0
Type I hemidesmosome assembly R-HSA-446107 2.476783e-01 0.606 0 0
MET receptor recycling R-HSA-8875656 2.476783e-01 0.606 0 0
Formation of annular gap junctions R-HSA-196025 2.476783e-01 0.606 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.476783e-01 0.606 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.069836e-01 0.684 0 0
ARMS-mediated activation R-HSA-170984 2.796174e-01 0.553 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.796174e-01 0.553 0 0
Gap junction degradation R-HSA-190873 2.796174e-01 0.553 0 0
MAPK1 (ERK2) activation R-HSA-112411 2.796174e-01 0.553 0 0
HCN channels R-HSA-1296061 4.060700e-01 0.391 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.060700e-01 0.391 1 1
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.060700e-01 0.391 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.060700e-01 0.391 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.060700e-01 0.391 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.060700e-01 0.391 0 0
Erythropoietin activates RAS R-HSA-9027284 2.294566e-01 0.639 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.114505e-01 0.507 0 0
Phosphorylation of the APC/C R-HSA-176412 2.523509e-01 0.598 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.429745e-01 0.465 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.429745e-01 0.465 0 0
Signaling by APC mutants R-HSA-4839744 3.429745e-01 0.465 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.429745e-01 0.465 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.429745e-01 0.465 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.429745e-01 0.465 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 4.554769e-01 0.342 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.554769e-01 0.342 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.554769e-01 0.342 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.554769e-01 0.342 0 0
Anchoring fibril formation R-HSA-2214320 3.740208e-01 0.427 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.740208e-01 0.427 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.740208e-01 0.427 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.934738e-01 0.713 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.934738e-01 0.713 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.054042e-01 0.687 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.971484e-01 0.705 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.971484e-01 0.705 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.044508e-01 0.393 0 0
Repression of WNT target genes R-HSA-4641265 4.044508e-01 0.393 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.044508e-01 0.393 0 0
Polymerase switching R-HSA-69091 4.044508e-01 0.393 0 0
Leading Strand Synthesis R-HSA-69109 4.044508e-01 0.393 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.044508e-01 0.393 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.044508e-01 0.393 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.044508e-01 0.393 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.044508e-01 0.393 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.007766e-01 0.300 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.007766e-01 0.300 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.007766e-01 0.300 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.007766e-01 0.300 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.007766e-01 0.300 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.007766e-01 0.300 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.007766e-01 0.300 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.007766e-01 0.300 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.857206e-01 0.544 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.427447e-01 0.615 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.023437e-01 0.519 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.341523e-01 0.362 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.687416e-01 0.571 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.543890e-01 0.595 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.088745e-01 0.680 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.820128e-01 0.550 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.293974e-01 0.482 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.156798e-01 0.381 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.630362e-01 0.334 0 0
Removal of the Flap Intermediate R-HSA-69166 4.630362e-01 0.334 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.630362e-01 0.334 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.423102e-01 0.266 0 0
Signaling by LTK in cancer R-HSA-9842640 5.423102e-01 0.266 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.423102e-01 0.266 0 0
STAT5 Activation R-HSA-9645135 5.423102e-01 0.266 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.423102e-01 0.266 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.423102e-01 0.266 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.423102e-01 0.266 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.868809e-01 0.412 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.868809e-01 0.412 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.195217e-01 0.377 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.910328e-01 0.309 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.910328e-01 0.309 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.910328e-01 0.309 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.910328e-01 0.309 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.038345e-01 0.394 0 0
PPARA activates gene expression R-HSA-1989781 2.518577e-01 0.599 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.543279e-01 0.451 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.451566e-01 0.462 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.608300e-01 0.336 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.608300e-01 0.336 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.375394e-01 0.359 0 0
Striated Muscle Contraction R-HSA-390522 4.575804e-01 0.340 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.803906e-01 0.236 0 0
Netrin mediated repulsion signals R-HSA-418886 5.803906e-01 0.236 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.803906e-01 0.236 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 5.803906e-01 0.236 0 0
DAG1 core M1 glycosylations R-HSA-8932506 5.803906e-01 0.236 0 0
Recycling of eIF2:GDP R-HSA-72731 5.803906e-01 0.236 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.200690e-01 0.377 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.200690e-01 0.377 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.616912e-01 0.336 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.129354e-01 0.290 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.033973e-01 0.298 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.549826e-01 0.342 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.692930e-01 0.329 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.308083e-01 0.275 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.460866e-01 0.263 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.460866e-01 0.263 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.460866e-01 0.263 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.692492e-01 0.245 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.554478e-01 0.255 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.919318e-01 0.407 0 0
RNA Polymerase III Transcription R-HSA-74158 5.129354e-01 0.290 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.549826e-01 0.342 0 0
Nucleotide Excision Repair R-HSA-5696398 5.621314e-01 0.250 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.483516e-01 0.261 0 0
HIV Transcription Elongation R-HSA-167169 3.868809e-01 0.412 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.808658e-01 0.419 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.160294e-01 0.287 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.060552e-01 0.686 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.007778e-01 0.300 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.056441e-01 0.392 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.592057e-01 0.445 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.868809e-01 0.412 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.803906e-01 0.236 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.424590e-01 0.266 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.910328e-01 0.309 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.801563e-01 0.420 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.460866e-01 0.263 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.796174e-01 0.553 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.608300e-01 0.336 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.158755e-01 0.666 0 0
PI3K/AKT activation R-HSA-198203 3.114505e-01 0.507 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.698994e-01 0.432 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.384280e-01 0.358 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.692492e-01 0.245 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.642182e-01 0.439 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.762945e-01 0.322 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.226808e-01 0.491 0 0
Cardiogenesis R-HSA-9733709 2.530501e-01 0.597 0 0
NF-kB is activated and signals survival R-HSA-209560 3.740208e-01 0.427 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.044508e-01 0.393 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.044508e-01 0.393 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.044508e-01 0.393 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.556457e-01 0.592 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.910328e-01 0.309 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.803906e-01 0.236 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.214008e-01 0.655 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.459520e-01 0.461 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.210356e-01 0.283 1 1
Regulation of signaling by CBL R-HSA-912631 3.459520e-01 0.461 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.156798e-01 0.381 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.868809e-01 0.412 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.868809e-01 0.412 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.461138e-01 0.609 0 0
Netrin-1 signaling R-HSA-373752 4.707923e-01 0.327 0 0
DNA Replication R-HSA-69306 3.205377e-01 0.494 0 0
Calcineurin activates NFAT R-HSA-2025928 2.796174e-01 0.553 0 0
Formation of the posterior neural plate R-HSA-9832991 3.429745e-01 0.465 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.554769e-01 0.342 0 0
PTK6 Down-Regulation R-HSA-8849472 4.554769e-01 0.342 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.393719e-01 0.621 0 0
PTK6 Expression R-HSA-8849473 5.803906e-01 0.236 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.044054e-01 0.297 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.692930e-01 0.329 0 0
DNA Double Strand Break Response R-HSA-5693606 4.754285e-01 0.323 0 0
HCMV Infection R-HSA-9609646 1.960048e-01 0.708 0 0
EPH-Ephrin signaling R-HSA-2682334 5.254911e-01 0.279 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.702328e-01 0.244 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.705918e-01 0.431 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.031485e-01 0.518 0 0
Co-inhibition by PD-1 R-HSA-389948 2.744294e-01 0.562 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.060700e-01 0.391 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.060700e-01 0.391 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.989511e-01 0.524 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.225075e-01 0.491 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.009742e-01 0.521 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.803906e-01 0.236 0 0
Signaling by NOTCH3 R-HSA-9012852 4.659900e-01 0.332 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.321591e-01 0.634 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.740208e-01 0.427 0 0
Rap1 signalling R-HSA-392517 3.459520e-01 0.461 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.425296e-01 0.615 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.425296e-01 0.615 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.425296e-01 0.615 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.425296e-01 0.615 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.423102e-01 0.266 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.825562e-01 0.316 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.189150e-01 0.285 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.530501e-01 0.597 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.128692e-01 0.290 0 0
Interleukin-6 family signaling R-HSA-6783589 4.828368e-01 0.316 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.648671e-01 0.577 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.796174e-01 0.553 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.648938e-01 0.577 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.176513e-01 0.662 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.555310e-01 0.593 0 0
p75NTR signals via NF-kB R-HSA-193639 4.910328e-01 0.309 0 0
Selective autophagy R-HSA-9663891 2.274769e-01 0.643 0 0
Signaling by NOTCH R-HSA-157118 3.308913e-01 0.480 0 0
Signalling to ERKs R-HSA-187687 3.023437e-01 0.519 0 0
ESR-mediated signaling R-HSA-8939211 5.554497e-01 0.255 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.428248e-01 0.354 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.293127e-01 0.640 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.293127e-01 0.640 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.521836e-01 0.453 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.521836e-01 0.453 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.521836e-01 0.453 0 0
Regulation of KIT signaling R-HSA-1433559 2.069836e-01 0.684 0 0
Disorders of Developmental Biology R-HSA-9675151 2.755517e-01 0.560 0 0
Reelin signalling pathway R-HSA-8866376 4.554769e-01 0.342 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.554769e-01 0.342 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.648938e-01 0.577 0 0
Signaling by AXIN mutants R-HSA-4839735 3.740208e-01 0.427 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.740208e-01 0.427 0 0
Regulation of IFNG signaling R-HSA-877312 4.044508e-01 0.393 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.007766e-01 0.300 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.308614e-01 0.637 0 0
MAP kinase activation R-HSA-450294 3.921376e-01 0.407 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.375394e-01 0.359 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.707923e-01 0.327 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.129354e-01 0.290 0 0
Glycogen storage diseases R-HSA-3229121 5.692492e-01 0.245 0 0
Signaling by NOTCH4 R-HSA-9013694 5.682722e-01 0.245 0 0
Hedgehog 'on' state R-HSA-5632684 3.801563e-01 0.420 0 0
Interleukin-17 signaling R-HSA-448424 3.672227e-01 0.435 0 0
Signaling by TGFB family members R-HSA-9006936 4.784933e-01 0.320 0 0
HCMV Late Events R-HSA-9610379 2.668240e-01 0.574 0 0
Neurexins and neuroligins R-HSA-6794361 4.207221e-01 0.376 0 0
Developmental Biology R-HSA-1266738 2.384936e-01 0.623 1 0
G2/M Transition R-HSA-69275 2.521880e-01 0.598 0 0
DNA Repair R-HSA-73894 5.232893e-01 0.281 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.031485e-01 0.518 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.922497e-01 0.534 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.832881e-01 0.316 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.554769e-01 0.342 0 0
MAPK family signaling cascades R-HSA-5683057 3.746391e-01 0.426 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.637025e-01 0.249 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.114505e-01 0.507 0 0
ERK/MAPK targets R-HSA-198753 3.926413e-01 0.406 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.441704e-01 0.264 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.692492e-01 0.245 0 0
FLT3 signaling in disease R-HSA-9682385 5.129354e-01 0.290 0 0
Cargo concentration in the ER R-HSA-5694530 4.002486e-01 0.398 0 0
G2/M Checkpoints R-HSA-69481 3.531779e-01 0.452 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.056441e-01 0.392 0 0
RMTs methylate histone arginines R-HSA-3214858 4.707923e-01 0.327 1 1
Signal regulatory protein family interactions R-HSA-391160 2.069836e-01 0.684 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.060700e-01 0.391 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.276455e-01 0.643 0 0
Disorders of Nervous System Development R-HSA-9697154 4.044508e-01 0.393 0 0
Pervasive developmental disorders R-HSA-9005895 4.044508e-01 0.393 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.044508e-01 0.393 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.007766e-01 0.300 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.803906e-01 0.236 0 0
Ub-specific processing proteases R-HSA-5689880 4.039197e-01 0.394 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.038345e-01 0.394 0 0
Mitophagy R-HSA-5205647 4.762945e-01 0.322 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.441704e-01 0.264 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.299397e-01 0.367 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.044508e-01 0.393 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.156798e-01 0.381 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.386447e-01 0.358 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.308083e-01 0.275 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.023437e-01 0.519 0 0
Cell-cell junction organization R-HSA-421270 3.307212e-01 0.481 0 0
Inhibition of membrane repair R-HSA-9635644 2.293127e-01 0.640 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.293127e-01 0.640 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.293127e-01 0.640 0 0
DSCAM interactions R-HSA-376172 2.934121e-01 0.533 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.521836e-01 0.453 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.523509e-01 0.598 0 0
Pyrophosphate hydrolysis R-HSA-71737 4.554769e-01 0.342 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.461138e-01 0.609 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.007766e-01 0.300 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.630362e-01 0.334 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.441704e-01 0.264 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.460866e-01 0.263 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.614167e-01 0.442 0 0
Downstream signal transduction R-HSA-186763 4.002486e-01 0.398 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.425296e-01 0.615 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.634638e-01 0.579 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.971484e-01 0.705 0 0
L1CAM interactions R-HSA-373760 5.743920e-01 0.241 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.446037e-01 0.352 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.294566e-01 0.639 0 0
Suppression of apoptosis R-HSA-9635465 3.429745e-01 0.465 0 0
Interleukin-37 signaling R-HSA-9008059 2.060552e-01 0.686 0 0
Tie2 Signaling R-HSA-210993 3.224489e-01 0.492 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.693754e-01 0.433 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.630362e-01 0.334 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.061106e-01 0.391 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.441704e-01 0.264 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.420629e-01 0.355 0 0
Signaling by VEGF R-HSA-194138 5.564955e-01 0.255 0 0
Formation of the anterior neural plate R-HSA-9823739 2.294566e-01 0.639 0 0
DNA Damage Bypass R-HSA-73893 3.749907e-01 0.426 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.699708e-01 0.569 0 0
Signaling by FGFR in disease R-HSA-1226099 4.190449e-01 0.378 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.698994e-01 0.432 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 2.934121e-01 0.533 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.158755e-01 0.666 0 0
The NLRP1 inflammasome R-HSA-844455 3.521836e-01 0.453 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.796174e-01 0.553 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.060700e-01 0.391 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.523509e-01 0.598 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.095508e-01 0.679 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.095508e-01 0.679 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.007766e-01 0.300 0 0
Negative regulation of MET activity R-HSA-6807004 3.693754e-01 0.433 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.910328e-01 0.309 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.672227e-01 0.435 1 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.386447e-01 0.358 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.180900e-01 0.286 0 0
Differentiation of T cells R-HSA-9945266 5.180900e-01 0.286 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.803906e-01 0.236 0 0
Regulation of PTEN localization R-HSA-8948747 5.803906e-01 0.236 0 0
Fibronectin matrix formation R-HSA-1566977 5.441704e-01 0.264 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.460866e-01 0.263 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.926413e-01 0.406 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.044054e-01 0.297 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.254991e-01 0.279 0 0
PI Metabolism R-HSA-1483255 5.184768e-01 0.285 0 0
Protein methylation R-HSA-8876725 4.910328e-01 0.309 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.796174e-01 0.553 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.634638e-01 0.579 1 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.934121e-01 0.533 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.476783e-01 0.606 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.554769e-01 0.342 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.989511e-01 0.524 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.740208e-01 0.427 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.341523e-01 0.362 0 0
CHL1 interactions R-HSA-447041 5.803906e-01 0.236 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.177964e-01 0.379 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.528254e-01 0.597 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.692492e-01 0.245 0 0
TNF signaling R-HSA-75893 3.226808e-01 0.491 0 0
Interleukin-2 family signaling R-HSA-451927 3.868809e-01 0.412 0 0
Physiological factors R-HSA-5578768 2.069836e-01 0.684 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.429745e-01 0.465 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.044054e-01 0.297 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.293974e-01 0.482 0 0
Interferon Signaling R-HSA-913531 2.730177e-01 0.564 0 0
TRP channels R-HSA-3295583 3.031485e-01 0.518 0 0
Neurofascin interactions R-HSA-447043 5.423102e-01 0.266 0 0
Growth hormone receptor signaling R-HSA-982772 4.608300e-01 0.336 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.971484e-01 0.705 0 0
Signaling by Leptin R-HSA-2586552 3.114505e-01 0.507 0 0
tRNA processing R-HSA-72306 4.747110e-01 0.324 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.531052e-01 0.257 0 0
PKR-mediated signaling R-HSA-9833482 4.959934e-01 0.305 0 0
SARS-CoV Infections R-HSA-9679506 5.774963e-01 0.238 0 0
Interleukin-7 signaling R-HSA-1266695 5.044054e-01 0.297 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.806826e-01 0.236 0 0
Centrosome maturation R-HSA-380287 5.809226e-01 0.236 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.809226e-01 0.236 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.823716e-01 0.235 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.823716e-01 0.235 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.823716e-01 0.235 0 0
Signaling by Erythropoietin R-HSA-9006335 5.856440e-01 0.232 0 0
Late endosomal microautophagy R-HSA-9615710 5.856440e-01 0.232 0 0
mRNA Capping R-HSA-72086 5.856440e-01 0.232 0 0
Platelet calcium homeostasis R-HSA-418360 5.856440e-01 0.232 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.933125e-01 0.227 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.933125e-01 0.227 0 0
Mismatch Repair R-HSA-5358508 5.933125e-01 0.227 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.933125e-01 0.227 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.933125e-01 0.227 0 0
Nephron development R-HSA-9831926 5.933125e-01 0.227 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.933905e-01 0.227 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.957560e-01 0.225 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.978534e-01 0.223 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.988156e-01 0.223 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.988156e-01 0.223 0 0
FLT3 Signaling R-HSA-9607240 5.988156e-01 0.223 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.046932e-01 0.218 0 0
Meiotic synapsis R-HSA-1221632 6.101935e-01 0.215 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.101935e-01 0.215 0 0
Vesicle-mediated transport R-HSA-5653656 6.111869e-01 0.214 0 0
Macroautophagy R-HSA-1632852 6.140029e-01 0.212 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.148645e-01 0.211 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.148645e-01 0.211 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.148645e-01 0.211 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.148645e-01 0.211 0 0
FOXO-mediated transcription R-HSA-9614085 6.149317e-01 0.211 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.153047e-01 0.211 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.153047e-01 0.211 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.153047e-01 0.211 0 0
Adrenoceptors R-HSA-390696 6.153047e-01 0.211 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.153047e-01 0.211 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.153047e-01 0.211 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.153047e-01 0.211 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.163557e-01 0.210 0 0
Specification of the neural plate border R-HSA-9834899 6.163557e-01 0.210 0 0
RNA Polymerase I Transcription R-HSA-73864 6.177473e-01 0.209 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.229255e-01 0.206 0 0
Chromosome Maintenance R-HSA-73886 6.235614e-01 0.205 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.381491e-01 0.195 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.381780e-01 0.195 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.383820e-01 0.195 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.383820e-01 0.195 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.383820e-01 0.195 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.383820e-01 0.195 0 0
Signaling by NODAL R-HSA-1181150 6.383820e-01 0.195 0 0
Glycogen synthesis R-HSA-3322077 6.383820e-01 0.195 0 0
Signal transduction by L1 R-HSA-445144 6.383820e-01 0.195 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.406835e-01 0.193 0 0
Signaling by WNT in cancer R-HSA-4791275 6.406835e-01 0.193 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.406835e-01 0.193 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.440200e-01 0.191 0 0
Defective pyroptosis R-HSA-9710421 6.457370e-01 0.190 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.457370e-01 0.190 0 0
Lipophagy R-HSA-9613354 6.473157e-01 0.189 0 0
ALK mutants bind TKIs R-HSA-9700645 6.473157e-01 0.189 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.473157e-01 0.189 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.473157e-01 0.189 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.473157e-01 0.189 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.473157e-01 0.189 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.473157e-01 0.189 0 0
WNT mediated activation of DVL R-HSA-201688 6.473157e-01 0.189 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.473157e-01 0.189 0 0
Interleukin-1 processing R-HSA-448706 6.473157e-01 0.189 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.473157e-01 0.189 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.473157e-01 0.189 0 0
Signaling by WNT R-HSA-195721 6.476573e-01 0.189 0 0
Autophagy R-HSA-9612973 6.479238e-01 0.188 0 0
IRE1alpha activates chaperones R-HSA-381070 6.489790e-01 0.188 0 0
Lagging Strand Synthesis R-HSA-69186 6.594010e-01 0.181 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.594010e-01 0.181 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.594010e-01 0.181 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.594010e-01 0.181 0 0
Proteasome assembly R-HSA-9907900 6.605454e-01 0.180 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.661628e-01 0.176 0 0
COPII-mediated vesicle transport R-HSA-204005 6.697687e-01 0.174 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.697687e-01 0.174 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.744062e-01 0.171 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.744062e-01 0.171 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.749285e-01 0.171 0 0
Nucleosome assembly R-HSA-774815 6.749285e-01 0.171 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.749285e-01 0.171 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.749285e-01 0.171 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.749675e-01 0.171 0 0
RSV-host interactions R-HSA-9833110 6.759124e-01 0.170 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.766647e-01 0.170 0 0
DNA replication initiation R-HSA-68952 6.766647e-01 0.170 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.766647e-01 0.170 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.766647e-01 0.170 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.766647e-01 0.170 0 0
Interleukin-27 signaling R-HSA-9020956 6.766647e-01 0.170 0 0
Formation of intermediate mesoderm R-HSA-9761174 6.766647e-01 0.170 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.766647e-01 0.170 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.766647e-01 0.170 0 0
Pexophagy R-HSA-9664873 6.766647e-01 0.170 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.766647e-01 0.170 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.766647e-01 0.170 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.766647e-01 0.170 0 0
Formation of apoptosome R-HSA-111458 6.766647e-01 0.170 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.766647e-01 0.170 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.766647e-01 0.170 0 0
Regulation of CDH11 function R-HSA-9762292 6.766647e-01 0.170 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.794278e-01 0.168 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.794278e-01 0.168 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.794278e-01 0.168 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.794278e-01 0.168 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.814597e-01 0.167 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.843397e-01 0.165 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.901946e-01 0.161 0 0
Regulation of beta-cell development R-HSA-186712 6.901946e-01 0.161 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.903690e-01 0.161 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.903690e-01 0.161 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.903690e-01 0.161 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.903690e-01 0.161 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.903690e-01 0.161 1 1
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.984820e-01 0.156 0 0
FGFR2 alternative splicing R-HSA-6803529 6.984820e-01 0.156 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.984820e-01 0.156 0 0
Signaling by KIT in disease R-HSA-9669938 6.984820e-01 0.156 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.984820e-01 0.156 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.984820e-01 0.156 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.984820e-01 0.156 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.984820e-01 0.156 0 0
Kinesins R-HSA-983189 7.023750e-01 0.153 0 0
Recycling pathway of L1 R-HSA-437239 7.024076e-01 0.153 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.035730e-01 0.153 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.035730e-01 0.153 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.035730e-01 0.153 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.035730e-01 0.153 0 0
PECAM1 interactions R-HSA-210990 7.035730e-01 0.153 0 0
Interleukin-2 signaling R-HSA-9020558 7.035730e-01 0.153 0 0
PERK regulates gene expression R-HSA-381042 7.057355e-01 0.151 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.057355e-01 0.151 0 0
Regulation of Apoptosis R-HSA-169911 7.057355e-01 0.151 0 0
Leishmania phagocytosis R-HSA-9664417 7.087041e-01 0.150 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.087041e-01 0.150 0 0
Parasite infection R-HSA-9664407 7.087041e-01 0.150 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.097184e-01 0.149 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.131561e-01 0.147 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.131908e-01 0.147 0 0
Interleukin-1 family signaling R-HSA-446652 7.131908e-01 0.147 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.155021e-01 0.145 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.165605e-01 0.145 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.165866e-01 0.145 0 0
Syndecan interactions R-HSA-3000170 7.165866e-01 0.145 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.166765e-01 0.145 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.191382e-01 0.143 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.205110e-01 0.142 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.205110e-01 0.142 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.205110e-01 0.142 0 0
Glycosphingolipid transport R-HSA-9845576 7.205110e-01 0.142 0 0
Signaling by PDGF R-HSA-186797 7.257247e-01 0.139 0 0
Degradation of CDH1 R-HSA-9766229 7.281679e-01 0.138 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.281679e-01 0.138 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.281679e-01 0.138 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 7.282435e-01 0.138 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.282435e-01 0.138 0 0
ERKs are inactivated R-HSA-202670 7.282435e-01 0.138 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.282435e-01 0.138 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.282435e-01 0.138 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.283523e-01 0.138 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.283523e-01 0.138 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.283523e-01 0.138 0 0
SLC transporter disorders R-HSA-5619102 7.318476e-01 0.136 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.337678e-01 0.134 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.337678e-01 0.134 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.337678e-01 0.134 0 0
Degradation of DVL R-HSA-4641258 7.347022e-01 0.134 0 0
Degradation of AXIN R-HSA-4641257 7.347022e-01 0.134 0 0
Collagen chain trimerization R-HSA-8948216 7.347022e-01 0.134 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.362760e-01 0.133 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.475074e-01 0.126 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.475074e-01 0.126 0 0
Insulin receptor signalling cascade R-HSA-74751 7.477267e-01 0.126 0 0
MHC class II antigen presentation R-HSA-2132295 7.493162e-01 0.125 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.500538e-01 0.125 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.508620e-01 0.124 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.508620e-01 0.124 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.508620e-01 0.124 0 0
MET activates RAS signaling R-HSA-8851805 7.508620e-01 0.124 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.508620e-01 0.124 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.508620e-01 0.124 0 0
Interleukin-35 Signalling R-HSA-8984722 7.508620e-01 0.124 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.508620e-01 0.124 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.508620e-01 0.124 0 0
OAS antiviral response R-HSA-8983711 7.508620e-01 0.124 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.522240e-01 0.124 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.522240e-01 0.124 0 0
Interleukin-1 signaling R-HSA-9020702 7.547526e-01 0.122 0 0
Cellular response to chemical stress R-HSA-9711123 7.551223e-01 0.122 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.613679e-01 0.118 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.613679e-01 0.118 0 0
Stabilization of p53 R-HSA-69541 7.613679e-01 0.118 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.636225e-01 0.117 0 0
MET activates PTK2 signaling R-HSA-8874081 7.654746e-01 0.116 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.654746e-01 0.116 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.654746e-01 0.116 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.715993e-01 0.113 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.715993e-01 0.113 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.715993e-01 0.113 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.715993e-01 0.113 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.715993e-01 0.113 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.715993e-01 0.113 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.715993e-01 0.113 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.715993e-01 0.113 0 0
Maturation of nucleoprotein R-HSA-9683610 7.715993e-01 0.113 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.715993e-01 0.113 0 0
Glycogen metabolism R-HSA-8982491 7.738638e-01 0.111 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.738638e-01 0.111 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.746081e-01 0.111 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.800613e-01 0.108 0 0
Signaling by Insulin receptor R-HSA-74752 7.805798e-01 0.108 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.858180e-01 0.105 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.858180e-01 0.105 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.858180e-01 0.105 0 0
Potential therapeutics for SARS R-HSA-9679191 7.875951e-01 0.104 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.876284e-01 0.104 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.906116e-01 0.102 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.906116e-01 0.102 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.906116e-01 0.102 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.906116e-01 0.102 0 0
Malate-aspartate shuttle R-HSA-9856872 7.906116e-01 0.102 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.906116e-01 0.102 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.906116e-01 0.102 0 0
HDL assembly R-HSA-8963896 7.906116e-01 0.102 0 0
P2Y receptors R-HSA-417957 7.906116e-01 0.102 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.906116e-01 0.102 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.933403e-01 0.101 0 0
Telomere Extension By Telomerase R-HSA-171319 7.938459e-01 0.100 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.938459e-01 0.100 0 0
Pyrimidine salvage R-HSA-73614 7.938459e-01 0.100 0 0
Insulin receptor recycling R-HSA-77387 7.938459e-01 0.100 0 0
Inflammasomes R-HSA-622312 7.938459e-01 0.100 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.955203e-01 0.099 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.972437e-01 0.098 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.972437e-01 0.098 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.019807e-01 0.096 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.051540e-01 0.094 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.058156e-01 0.094 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.058156e-01 0.094 0 0
DNA methylation R-HSA-5334118 8.068609e-01 0.093 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.068609e-01 0.093 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.068609e-01 0.093 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.068609e-01 0.093 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.068609e-01 0.093 0 0
Homology Directed Repair R-HSA-5693538 8.074029e-01 0.093 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.074029e-01 0.093 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.080423e-01 0.093 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.080423e-01 0.093 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.080423e-01 0.093 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.080423e-01 0.093 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.080423e-01 0.093 0 0
Signaling by Activin R-HSA-1502540 8.080423e-01 0.093 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.080423e-01 0.093 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.080423e-01 0.093 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.080423e-01 0.093 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.080423e-01 0.093 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.080423e-01 0.093 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.081549e-01 0.093 0 0
Depyrimidination R-HSA-73928 8.081549e-01 0.093 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.119467e-01 0.090 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.119467e-01 0.090 0 0
Reproduction R-HSA-1474165 8.128611e-01 0.090 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.140753e-01 0.089 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.140753e-01 0.089 0 0
IRS-mediated signalling R-HSA-112399 8.145572e-01 0.089 0 0
Regulation of CDH1 Function R-HSA-9764561 8.145572e-01 0.089 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.161028e-01 0.088 0 0
Stimuli-sensing channels R-HSA-2672351 8.161028e-01 0.088 0 0
Meiosis R-HSA-1500620 8.162325e-01 0.088 1 0
Response of Mtb to phagocytosis R-HSA-9637690 8.185663e-01 0.087 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.191387e-01 0.087 0 0
DAP12 signaling R-HSA-2424491 8.191387e-01 0.087 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.191387e-01 0.087 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.191387e-01 0.087 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.192216e-01 0.087 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.228681e-01 0.085 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.230492e-01 0.085 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.238431e-01 0.084 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.240229e-01 0.084 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.240229e-01 0.084 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.240229e-01 0.084 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.240229e-01 0.084 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.240229e-01 0.084 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.240229e-01 0.084 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.240229e-01 0.084 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.240229e-01 0.084 0 0
Negative regulation of FLT3 R-HSA-9706369 8.240229e-01 0.084 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.240229e-01 0.084 0 0
Activation of SMO R-HSA-5635838 8.240229e-01 0.084 0 0
Attachment and Entry R-HSA-9678110 8.240229e-01 0.084 0 0
Telomere Maintenance R-HSA-157579 8.262752e-01 0.083 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.284929e-01 0.082 1 1
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.284929e-01 0.082 0 0
Viral Infection Pathways R-HSA-9824446 8.293241e-01 0.081 0 0
Trafficking of AMPA receptors R-HSA-399719 8.307119e-01 0.081 0 0
Budding and maturation of HIV virion R-HSA-162588 8.307119e-01 0.081 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.307119e-01 0.081 0 0
Extension of Telomeres R-HSA-180786 8.322458e-01 0.080 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.330405e-01 0.079 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.330405e-01 0.079 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.379500e-01 0.077 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.379500e-01 0.077 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.379500e-01 0.077 0 0
Somitogenesis R-HSA-9824272 8.379500e-01 0.077 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.386740e-01 0.076 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.386740e-01 0.076 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.386740e-01 0.076 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.386740e-01 0.076 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.386740e-01 0.076 0 0
Coenzyme A biosynthesis R-HSA-196783 8.386740e-01 0.076 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.386740e-01 0.076 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.386740e-01 0.076 0 0
Interferon gamma signaling R-HSA-877300 8.398101e-01 0.076 0 0
Signaling by ERBB2 R-HSA-1227986 8.405493e-01 0.075 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.456535e-01 0.073 0 0
Protein ubiquitination R-HSA-8852135 8.456535e-01 0.073 0 0
Hedgehog 'off' state R-HSA-5610787 8.461411e-01 0.073 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.469534e-01 0.072 0 0
Diseases of DNA repair R-HSA-9675135 8.469534e-01 0.072 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.480133e-01 0.072 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.485048e-01 0.071 0 0
Collagen degradation R-HSA-1442490 8.485048e-01 0.071 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.518729e-01 0.070 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.518729e-01 0.070 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.518729e-01 0.070 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.518729e-01 0.070 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.518729e-01 0.070 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.521062e-01 0.070 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.521062e-01 0.070 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.521062e-01 0.070 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.521062e-01 0.070 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.521062e-01 0.070 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.521062e-01 0.070 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.521062e-01 0.070 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.521062e-01 0.070 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.521062e-01 0.070 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.526565e-01 0.069 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.537633e-01 0.069 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.538344e-01 0.069 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.538344e-01 0.069 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.555187e-01 0.068 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.561219e-01 0.067 0 0
Base Excision Repair R-HSA-73884 8.581972e-01 0.066 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.615233e-01 0.065 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.615233e-01 0.065 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.615233e-01 0.065 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.615233e-01 0.065 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.615233e-01 0.065 0 0
Semaphorin interactions R-HSA-373755 8.634106e-01 0.064 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.634106e-01 0.064 0 0
Ribosome-associated quality control R-HSA-9948299 8.634988e-01 0.064 0 0
Signaling by Hedgehog R-HSA-5358351 8.634988e-01 0.064 0 0
Co-stimulation by CD28 R-HSA-389356 8.636617e-01 0.064 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.644206e-01 0.063 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.644206e-01 0.063 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.644206e-01 0.063 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.644206e-01 0.063 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.644206e-01 0.063 0 0
Ephrin signaling R-HSA-3928664 8.644206e-01 0.063 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.644206e-01 0.063 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.644206e-01 0.063 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.644206e-01 0.063 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.644206e-01 0.063 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.644206e-01 0.063 0 0
Platelet sensitization by LDL R-HSA-432142 8.644206e-01 0.063 0 0
GAB1 signalosome R-HSA-180292 8.644206e-01 0.063 0 0
Apoptotic factor-mediated response R-HSA-111471 8.644206e-01 0.063 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 8.644206e-01 0.063 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.649390e-01 0.063 0 0
PCP/CE pathway R-HSA-4086400 8.661397e-01 0.062 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.697419e-01 0.061 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.703017e-01 0.060 0 0
IGF1R signaling cascade R-HSA-2428924 8.703807e-01 0.060 0 0
Dual Incision in GG-NER R-HSA-5696400 8.705946e-01 0.060 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.705946e-01 0.060 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.705946e-01 0.060 0 0
Signaling by NOTCH2 R-HSA-1980145 8.705946e-01 0.060 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.705946e-01 0.060 0 0
Gap junction trafficking and regulation R-HSA-157858 8.713982e-01 0.060 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.713982e-01 0.060 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.724390e-01 0.059 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.745299e-01 0.058 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.757104e-01 0.058 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.757104e-01 0.058 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.757104e-01 0.058 0 0
Translesion Synthesis by POLH R-HSA-110320 8.757104e-01 0.058 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.757104e-01 0.058 0 0
Diseases of hemostasis R-HSA-9671793 8.757104e-01 0.058 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.757104e-01 0.058 0 0
Maturation of nucleoprotein R-HSA-9694631 8.757104e-01 0.058 0 0
The NLRP3 inflammasome R-HSA-844456 8.757104e-01 0.058 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.757104e-01 0.058 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.760236e-01 0.057 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.770422e-01 0.057 0 0
PI3K Cascade R-HSA-109704 8.787438e-01 0.056 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.787438e-01 0.056 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.803756e-01 0.055 0 0
Signaling by Interleukins R-HSA-449147 8.807752e-01 0.055 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.860607e-01 0.053 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.860607e-01 0.053 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.860607e-01 0.053 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.860607e-01 0.053 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.860607e-01 0.053 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.860607e-01 0.053 0 0
Protein hydroxylation R-HSA-9629569 8.860607e-01 0.053 0 0
Nephrin family interactions R-HSA-373753 8.860607e-01 0.053 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.863781e-01 0.052 0 0
GPVI-mediated activation cascade R-HSA-114604 8.871164e-01 0.052 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.871164e-01 0.052 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.894792e-01 0.051 0 0
Kidney development R-HSA-9830369 8.894792e-01 0.051 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.902761e-01 0.050 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.919315e-01 0.050 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.923241e-01 0.049 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.923241e-01 0.049 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.923241e-01 0.049 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.923241e-01 0.049 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.946233e-01 0.048 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.946233e-01 0.048 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.946233e-01 0.048 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.955496e-01 0.048 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.955496e-01 0.048 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.955496e-01 0.048 0 0
Signalling to RAS R-HSA-167044 8.955496e-01 0.048 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.955496e-01 0.048 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.955496e-01 0.048 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.955496e-01 0.048 0 0
Cellular response to starvation R-HSA-9711097 8.957863e-01 0.048 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.015431e-01 0.045 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.016634e-01 0.045 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.016634e-01 0.045 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.038275e-01 0.044 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.038275e-01 0.044 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.042488e-01 0.044 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.042488e-01 0.044 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.042488e-01 0.044 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.042488e-01 0.044 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.042488e-01 0.044 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.042488e-01 0.044 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.042488e-01 0.044 0 0
Assembly Of The HIV Virion R-HSA-175474 9.042488e-01 0.044 0 0
Glutathione synthesis and recycling R-HSA-174403 9.042488e-01 0.044 0 0
Attachment and Entry R-HSA-9694614 9.042488e-01 0.044 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.045238e-01 0.044 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.060734e-01 0.043 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.082624e-01 0.042 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.082624e-01 0.042 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.082624e-01 0.042 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.098335e-01 0.041 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.099656e-01 0.041 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.122240e-01 0.040 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.122240e-01 0.040 0 0
LDL clearance R-HSA-8964038 9.122240e-01 0.040 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.122240e-01 0.040 0 0
Ethanol oxidation R-HSA-71384 9.122240e-01 0.040 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.135204e-01 0.039 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.144448e-01 0.039 0 0
Diseases of Immune System R-HSA-5260271 9.144448e-01 0.039 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.144448e-01 0.039 0 0
Cilium Assembly R-HSA-5617833 9.149220e-01 0.039 0 0
Ion homeostasis R-HSA-5578775 9.154594e-01 0.038 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.195353e-01 0.036 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.195353e-01 0.036 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.195353e-01 0.036 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.195353e-01 0.036 0 0
Carnitine shuttle R-HSA-200425 9.195353e-01 0.036 0 0
Formation of the ureteric bud R-HSA-9830674 9.195353e-01 0.036 0 0
Maturation of spike protein R-HSA-9694548 9.202344e-01 0.036 0 0
Ca2+ pathway R-HSA-4086398 9.204123e-01 0.036 0 0
Peptide chain elongation R-HSA-156902 9.226882e-01 0.035 0 0
Diseases of programmed cell death R-HSA-9645723 9.226882e-01 0.035 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.247379e-01 0.034 0 0
Platelet degranulation R-HSA-114608 9.247658e-01 0.034 0 0
Dual incision in TC-NER R-HSA-6782135 9.252420e-01 0.034 0 0
Intra-Golgi traffic R-HSA-6811438 9.256536e-01 0.034 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.262381e-01 0.033 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.262381e-01 0.033 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.262381e-01 0.033 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.262381e-01 0.033 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.262381e-01 0.033 0 0
Neurodegenerative Diseases R-HSA-8863678 9.262381e-01 0.033 0 0
ER-Phagosome pathway R-HSA-1236974 9.265933e-01 0.033 0 0
Neurotransmitter release cycle R-HSA-112310 9.303219e-01 0.031 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.307238e-01 0.031 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.323828e-01 0.030 0 0
Long-term potentiation R-HSA-9620244 9.323828e-01 0.030 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.323828e-01 0.030 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.323828e-01 0.030 0 0
Laminin interactions R-HSA-3000157 9.323828e-01 0.030 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.323828e-01 0.030 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.323828e-01 0.030 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.323828e-01 0.030 0 0
Formation of the nephric duct R-HSA-9830364 9.323828e-01 0.030 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.338807e-01 0.030 0 0
Metabolism of polyamines R-HSA-351202 9.339764e-01 0.030 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.354657e-01 0.029 0 0
Signaling by FGFR4 R-HSA-5654743 9.354657e-01 0.029 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.354657e-01 0.029 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.365955e-01 0.028 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.380161e-01 0.028 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.380161e-01 0.028 0 0
Metalloprotease DUBs R-HSA-5689901 9.380161e-01 0.028 0 0
Urea cycle R-HSA-70635 9.380161e-01 0.028 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.380161e-01 0.028 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.380161e-01 0.028 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.390680e-01 0.027 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.397093e-01 0.027 0 0
Gap junction trafficking R-HSA-190828 9.398987e-01 0.027 0 0
DAP12 interactions R-HSA-2172127 9.398987e-01 0.027 0 0
ABC transporter disorders R-HSA-5619084 9.399995e-01 0.027 0 0
Integrin cell surface interactions R-HSA-216083 9.399995e-01 0.027 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.417608e-01 0.026 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.417608e-01 0.026 0 0
Packaging Of Telomere Ends R-HSA-171306 9.431803e-01 0.025 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.431803e-01 0.025 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.431803e-01 0.025 0 0
Signaling by BMP R-HSA-201451 9.431803e-01 0.025 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.431803e-01 0.025 0 0
Cristae formation R-HSA-8949613 9.431803e-01 0.025 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.431803e-01 0.025 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.431803e-01 0.025 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.431803e-01 0.025 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.431803e-01 0.025 0 0
Insulin processing R-HSA-264876 9.431803e-01 0.025 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.431803e-01 0.025 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.431803e-01 0.025 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.440414e-01 0.025 0 0
Signaling by FGFR3 R-HSA-5654741 9.440414e-01 0.025 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.449285e-01 0.025 0 0
Signaling by FGFR2 R-HSA-5654738 9.465223e-01 0.024 0 0
Collagen formation R-HSA-1474290 9.465419e-01 0.024 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.477809e-01 0.023 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.479145e-01 0.023 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.479145e-01 0.023 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.479145e-01 0.023 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.479145e-01 0.023 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.479145e-01 0.023 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.479145e-01 0.023 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.481407e-01 0.023 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.486868e-01 0.023 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.495342e-01 0.022 0 0
Amyloid fiber formation R-HSA-977225 9.495342e-01 0.022 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.515252e-01 0.022 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.515252e-01 0.022 0 0
Synthesis of PC R-HSA-1483191 9.515252e-01 0.022 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.519649e-01 0.021 0 0
Eukaryotic Translation Termination R-HSA-72764 9.520116e-01 0.021 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.522545e-01 0.021 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.522545e-01 0.021 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.522545e-01 0.021 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.522545e-01 0.021 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.522545e-01 0.021 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.562332e-01 0.019 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.562332e-01 0.019 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.562332e-01 0.019 0 0
Developmental Cell Lineages R-HSA-9734767 9.564069e-01 0.019 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.583648e-01 0.018 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.592657e-01 0.018 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.598805e-01 0.018 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.598805e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.602956e-01 0.018 0 0
DAG1 glycosylations R-HSA-8931838 9.632241e-01 0.016 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.632241e-01 0.016 0 0
ABC-family proteins mediated transport R-HSA-382556 9.635284e-01 0.016 0 0
Muscle contraction R-HSA-397014 9.643846e-01 0.016 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.651283e-01 0.015 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.654365e-01 0.015 0 0
Selenocysteine synthesis R-HSA-2408557 9.655022e-01 0.015 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.655022e-01 0.015 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.662891e-01 0.015 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.662891e-01 0.015 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.662891e-01 0.015 0 0
G-protein beta:gamma signalling R-HSA-397795 9.662891e-01 0.015 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.662891e-01 0.015 0 0
Recycling of bile acids and salts R-HSA-159418 9.662891e-01 0.015 0 0
Post NMDA receptor activation events R-HSA-438064 9.666181e-01 0.015 0 0
ECM proteoglycans R-HSA-3000178 9.673313e-01 0.014 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.673313e-01 0.014 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.673772e-01 0.014 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.686570e-01 0.014 0 0
Smooth Muscle Contraction R-HSA-445355 9.686570e-01 0.014 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.690989e-01 0.014 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.690989e-01 0.014 0 0
Viral mRNA Translation R-HSA-192823 9.691577e-01 0.014 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.699712e-01 0.013 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.703733e-01 0.013 0 0
Cardiac conduction R-HSA-5576891 9.707963e-01 0.013 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.708750e-01 0.013 0 0
Gap junction assembly R-HSA-190861 9.716747e-01 0.012 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.716747e-01 0.012 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.716747e-01 0.012 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.716747e-01 0.012 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.716747e-01 0.012 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.716747e-01 0.012 0 0
Downstream TCR signaling R-HSA-202424 9.721420e-01 0.012 0 0
Signaling by ERBB4 R-HSA-1236394 9.731778e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.740359e-01 0.011 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.740359e-01 0.011 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.740359e-01 0.011 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.740359e-01 0.011 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.740359e-01 0.011 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.740359e-01 0.011 0 0
Signaling by FGFR1 R-HSA-5654736 9.748654e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.748654e-01 0.011 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.748955e-01 0.011 0 0
Neddylation R-HSA-8951664 9.753363e-01 0.011 0 0
Calmodulin induced events R-HSA-111933 9.762004e-01 0.010 0 0
CaM pathway R-HSA-111997 9.762004e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.762004e-01 0.010 0 0
Synthesis of PA R-HSA-1483166 9.766570e-01 0.010 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.768007e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.773211e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.780223e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.781833e-01 0.010 0 0
Voltage gated Potassium channels R-HSA-1296072 9.781846e-01 0.010 0 0
Cleavage of the damaged purine R-HSA-110331 9.781846e-01 0.010 0 0
Metabolism of folate and pterines R-HSA-196757 9.781846e-01 0.010 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.783248e-01 0.010 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.800034e-01 0.009 0 0
Depurination R-HSA-73927 9.800034e-01 0.009 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.800034e-01 0.009 0 0
Elastic fibre formation R-HSA-1566948 9.800034e-01 0.009 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.800034e-01 0.009 0 0
TCR signaling R-HSA-202403 9.804760e-01 0.009 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.807190e-01 0.008 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.813209e-01 0.008 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.816707e-01 0.008 0 0
PLC beta mediated events R-HSA-112043 9.826641e-01 0.008 0 0
Nucleotide salvage R-HSA-8956321 9.826641e-01 0.008 0 0
Generation of second messenger molecules R-HSA-202433 9.831991e-01 0.007 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.831991e-01 0.007 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.846001e-01 0.007 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.846001e-01 0.007 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.846001e-01 0.007 0 0
Signaling by FGFR R-HSA-190236 9.849784e-01 0.007 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.853268e-01 0.006 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.854313e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.855633e-01 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.858844e-01 0.006 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.858844e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9683701 9.858844e-01 0.006 0 0
Ion transport by P-type ATPases R-HSA-936837 9.861547e-01 0.006 0 0
Toll-like Receptor Cascades R-HSA-168898 9.868808e-01 0.006 0 0
Ca-dependent events R-HSA-111996 9.870616e-01 0.006 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.870616e-01 0.006 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.871582e-01 0.006 0 0
G-protein mediated events R-HSA-112040 9.889572e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.891299e-01 0.005 0 0
Amine ligand-binding receptors R-HSA-375280 9.891299e-01 0.005 0 0
Surfactant metabolism R-HSA-5683826 9.891299e-01 0.005 0 0
Interleukin-12 family signaling R-HSA-447115 9.895758e-01 0.005 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.895758e-01 0.005 0 0
Regulated Necrosis R-HSA-5218859 9.897620e-01 0.004 0 0
DAG and IP3 signaling R-HSA-1489509 9.900367e-01 0.004 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.900367e-01 0.004 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.908678e-01 0.004 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.908678e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.915310e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.918478e-01 0.004 0 0
rRNA processing R-HSA-72312 9.922206e-01 0.003 0 0
Intraflagellar transport R-HSA-5620924 9.923280e-01 0.003 0 0
Gluconeogenesis R-HSA-70263 9.923280e-01 0.003 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.930010e-01 0.003 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.930010e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.931230e-01 0.003 0 0
Protein folding R-HSA-391251 9.931230e-01 0.003 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.940210e-01 0.003 0 0
Meiotic recombination R-HSA-912446 9.940926e-01 0.003 1 1
FCERI mediated MAPK activation R-HSA-2871796 9.942663e-01 0.002 0 0
Interleukin-12 signaling R-HSA-9020591 9.944374e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.950375e-01 0.002 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.951166e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.952299e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.952299e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.958313e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.958759e-01 0.002 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.959114e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.959515e-01 0.002 0 0
Digestion R-HSA-8935690 9.961792e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.964982e-01 0.002 0 0
Adaptive Immune System R-HSA-1280218 9.964982e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.970584e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.973040e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.973040e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.973040e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.975291e-01 0.001 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.975845e-01 0.001 0 0
Digestion and absorption R-HSA-8963743 9.979245e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.983419e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.984023e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.984515e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.984515e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.985358e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.986581e-01 0.001 0 0
Hemostasis R-HSA-109582 9.987715e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.988054e-01 0.001 0 0
Neutrophil degranulation R-HSA-6798695 9.988792e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990534e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.990727e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.990727e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991418e-01 0.000 0 0
Integration of energy metabolism R-HSA-163685 9.991922e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992050e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.992082e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.992684e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.992714e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.993237e-01 0.000 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.993364e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.993608e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.993628e-01 0.000 0 0
Translation R-HSA-72766 9.994815e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994881e-01 0.000 0 0
Opioid Signalling R-HSA-111885 9.995079e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.995455e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.995568e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997183e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997399e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.997444e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.997444e-01 0.000 0 0
Neuronal System R-HSA-112316 9.998246e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.998292e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998729e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999283e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999327e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999389e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999576e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999694e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999788e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999869e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999893e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999930e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999932e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999945e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999954e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999965e-01 0.000 0 0
Immune System R-HSA-168256 9.999972e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999973e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999989e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999993e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999994e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999996e-01 0.000 0 0
Disease R-HSA-1643685 9.999997e-01 0.000 1 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999999e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.000000e+00 0.000 1 1
Diseases of Cellular Senescence R-HSA-9630747 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.000000e+00 0.000 1 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.000000e+00 0.000 1 1
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.000000e+00 0.000 1 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.000000e+00 0.000 1 1
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.000000e+00 0.000 1 1
Diseases of cellular response to stress R-HSA-9675132 1.000000e+00 0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways