OSR1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14818	Y153	Sugiyama	PSMA7 HSPC	IVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFLE
O15127	T109	Sugiyama	SCAMP2	QEELDRKAAELERKERELQNtVANLHVRQNNWPPLPSWCPV
O75369	T907	Sugiyama	FLNB FLN1L FLN3 TABP TAP	PLPGDAVKDLDIIDNyDysHtVKYtPtQQGNMQVLVTYGGD
O75821	T206	Sugiyama	EIF3G EIF3S4	LGLstGEKEKLPGELEPVQAtQNKtGKYVPPsLRDGAsRRG
O75821	T240	Sugiyama	EIF3G EIF3S4	DGAsRRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFR
O95747	S339	Sugiyama	OXSR1 KIAA1101 OSR1	RRVPGssGRLHKtEDGGWEWsDDEFDEEsEEGKAAIsQLRs
O95747	S355	Sugiyama	OXSR1 KIAA1101 OSR1	GWEWsDDEFDEEsEEGKAAIsQLRsPRVKESISNSELFPTT
O95747	S359	Sugiyama	OXSR1 KIAA1101 OSR1	sDDEFDEEsEEGKAAIsQLRsPRVKESISNSELFPTTDPVG
O95747	S510	Sugiyama	OXSR1 KIAA1101 OSR1	VEEPQsNRsVTFKLASGVEGsDIPDDGKLIGFAQLSIS___
O95747	T331	Sugiyama	OXSR1 KIAA1101 OSR1	ISERAKKVRRVPGssGRLHKtEDGGWEWsDDEFDEEsEEGK
O95757	S587	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
P02786	S151	Sugiyama	TFRC	LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P02786	T336	Sugiyama	TFRC	FNHTQFPPSRSSGLPNIPVQtISRAAAEKLFGNMEGDCPSD
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083	T223	Sugiyama	ANXA1 ANX1 LPC1	ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05976	T146	Sugiyama	MYL1	QATYEDFVEGLRVFDKEGNGtVMGAELRHVLATLGEKMKEE
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06744	T218	Sugiyama	GPI	QLNPESSLFIIASKTFTTQEtITNAEtAKEWFLQAAKDPSA
P06748	S43	Sugiyama	NPM1 NPM	LKADKDyHFKVDNDENEHQLsLRTVsLGAGAKDELHIVEAE
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P08238	T616	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	yGWTANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIVE
P08590	T147	Sugiyama	MYL3	tGtYEDFVEGLRVFDKEGNGtVMGAELRHVLAtLGERLtED
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10636	T30	PSP	MAPT MAPTL MTBT1 TAU	VMEDHAGTyGLGDRKDQGGytMHQDQEGDtDAGLKEsPLQt
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11586	T128	Sugiyama	MTHFD1 MTHFC MTHFD	SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13987	T76	Sugiyama	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880	T285	Sugiyama	RPS2 RPS4	PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P20618	S157	Sugiyama	PSMB1 PSC5	IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P23246	S283	Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23526	S183	Sugiyama	AHCY SAHH	NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23526	T157	Sugiyama	AHCY SAHH	NLIHTKYPQLLPGIRGIsEEtTTGVHNLyKMMANGILKVPA
P24752	T220	Sugiyama	ACAT1 ACAT MAT	TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P27816	T521	Sugiyama	MAP4	GLLKDMsPLsEtEMALGKDVtPPPEtEVVLIKNVCLPPEME
P28066	T14	Sugiyama	PSMA5	_______MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLG
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29966	S27	Sugiyama	MARCKS MACS PRKCSL	KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P41091	T21	Sugiyama	EIF2S3 EIF2G	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49327	T309	Sugiyama	FASN FAS	yIEAHGtGTKVGDPQELNGItRALCAtRQEPLLIGsTKSNM
P49773	T17	Sugiyama	HINT1 HINT PKCI1 PRKCNH1	____MADEIAKAQVARPGGDtIFGKIIRKEIPAKIIFEDDR
P50395	T205	Sugiyama	GDI2 RABGDIB	TGHALALYRtDDyLDQPCyEtINRIKLYsEsLARYGKsPYL
P52907	T217	Sugiyama	CAPZA1	HYYEDGNVQLVSHKDVQDsLtVsNEAQtAKEFIKIIENAEN
P52948	T687	Sugiyama	NUP98 ADAR2	IPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEGssEE
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55011	T203	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	SLC12A2 NKCC1	SSLHSGGGGGSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPR
P55011	T207	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	SLC12A2 NKCC1	SGGGGGSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPRIDHy
P55011	T212	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	SLC12A2 NKCC1	GSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPRIDHyRHtAA
P55011	T217	EPSD\|PSP	SLC12A2 NKCC1	QHYYYDtHTNtYYLRtFGHNtMDAVPRIDHyRHtAAQLGEK
P55011	T230	EPSD\|PSP	SLC12A2 NKCC1	LRtFGHNtMDAVPRIDHyRHtAAQLGEKLLRPsLAELHDEL
P55017	S73	EPSD\|PSP	SLC12A3 NCC TSC	MRtFGYNtIDVVPTYEHYANsTQPGEPRKVRPTLADLHsFL
P55017	T46	EPSD\|PSP	SLC12A3 NCC TSC	LSSDEPSPPAAYDSSHPSHLtHSStFCMRtFGYNtIDVVPT
P55017	T55	EPSD\|PSP	SLC12A3 NCC TSC	AAYDSSHPSHLtHSStFCMRtFGYNtIDVVPTYEHYANsTQ
P55017	T60	SIGNOR\|EPSD\|PSP	SLC12A3 NCC TSC	SHPSHLtHSStFCMRtFGYNtIDVVPTYEHYANsTQPGEPR
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60484	T382	Sugiyama	PTEN MMAC1 TEP1	sTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItK
P60484	T383	Sugiyama	PTEN MMAC1 TEP1	TSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T201	Sugiyama	ACTB	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280	T54	Sugiyama	RPS11	PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979	T147	Sugiyama	RPS27A UBA80 UBCEP1	GAGVFMAsHFDRHyCGKCCLtyCFNKPEDK___________
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T201	Sugiyama	ACTG1 ACTG	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P84022	T179	PSP	SMAD3 MADH3	SIPENTNFPAGIEPQSNIPEtPPPGYLSEDGETSDHQMNHS
Q01105	S165	Sugiyama	SET	PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020	T136	Sugiyama	RPL18	AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q13153	T84	SIGNOR\|iPTMNet\|EPSD	PAK1	TNKKKEKERPEISLPSDFEHtIHVGFDAVTGEFTGMPEQWA
Q13561	T315	Sugiyama	DCTN2 DCTN50	KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13621	S120	EPSD\|PSP	SLC12A1 NKCC2	tFGHNtMDAVPKIEYYRNtGsIsGPKVNRPsLLEIHEQLAK
Q13621	S130	SIGNOR	SLC12A1 NKCC2	PKIEYYRNtGsIsGPKVNRPsLLEIHEQLAKNVAVTPSSAD
Q13621	S91	SIGNOR	SLC12A1 NKCC2	DNFLQSGETAKTDASFHAYDsHTNtYYLQtFGHNtMDAVPK
Q13621	T100	SIGNOR\|EPSD\|PSP	SLC12A1 NKCC2	AKTDASFHAYDsHTNtYYLQtFGHNtMDAVPKIEYYRNtGs
Q13621	T105	SIGNOR\|EPSD\|PSP	SLC12A1 NKCC2	SFHAYDsHTNtYYLQtFGHNtMDAVPKIEYYRNtGsIsGPK
Q13621	T118	EPSD\|PSP	SLC12A1 NKCC2	LQtFGHNtMDAVPKIEYYRNtGsIsGPKVNRPsLLEIHEQL
Q13621	T95	EPSD\|PSP	SLC12A1 NKCC2	QSGETAKTDASFHAYDsHTNtYYLQtFGHNtMDAVPKIEYY
Q14152	T1378	Sugiyama	EIF3A EIF3S10 KIAA0139	AEKDREsLRRTKNEtDEDGWttVRR________________
Q14247	S113	Sugiyama	CTTN EMS1	DRMDKsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVD
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15796	T220	PSP	SMAD2 MADH2 MADR2	IPENTNFPAGIEPQSNYIPEtPPPGYISEDGETSDQQLNQs
Q16658	T239	Sugiyama	FSCN1 FAN1 HSN SNL	GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q2VIR3	T21	Sugiyama	EIF2S3B	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q58FF7	T489	Sugiyama	HSP90AB3P HSP90BC	YGWTANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIME
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IYE1	S680	Sugiyama	CCDC13	LTTRLAIQVEENEMLKAALGsALRGKEEDFRMYHEILGQVK
Q92598	T63	Sugiyama	HSPH1 HSP105 HSP110 KIAA0201	SKNRTIGVAAKNQQITHANNtVsNFKRFHGRAFNDPFIQKE
Q92871	T246	Sugiyama	PMM1 PMMH22	DFEIFADPRTVGHSVVsPQDtVQRCREIFFPETAHEA____
Q96G46	T99	Sugiyama	DUS3L	DGQtADGQtEEAAEPGEQLQtQKRARGQNKGRPHVKPTNYD
Q99426	T120	Sugiyama	TBCB CG22 CKAP1	DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99832	S59	Sugiyama	CCT7 CCTH NIP7-1	TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q99832	T57	Sugiyama	CCT7 CCTH NIP7-1	RTTLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAK
Q99832	T64	Sugiyama	CCT7 CCTH NIP7-1	GMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTLVDIAK
Q9BX95	T114	Sugiyama	SGPP1 SPP1	AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9P2E9	T684	Sugiyama	RRBP1 KIAA1398	EGEAQRLIEILSEKAGIIQDtWHKATQKGDPVAILKRQLEE
Q9UKV3	S388	Sugiyama	ACIN1 ACINUS KIAA0670	EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UQ80	T200	Sugiyama	PA2G4 EBP1	TPIEGMLSHQLKQHVIDGEKtIIQNPTDQQKKDHEKAEFEV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Axon guidance	R-HSA-422475	9.974838e-09	8.001
EPH-Ephrin signaling	R-HSA-2682334	2.879614e-08	7.541
Apoptotic execution phase	R-HSA-75153	3.814306e-08	7.419
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.416486e-08	7.355
Nervous system development	R-HSA-9675108	7.315479e-08	7.136
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.993488e-07	6.700
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.083850e-06	5.681
EPHA-mediated growth cone collapse	R-HSA-3928663	6.856239e-06	5.164
Cell Cycle	R-HSA-1640170	1.669191e-05	4.777
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.685450e-05	4.773
PECAM1 interactions	R-HSA-210990	2.015630e-05	4.696
Signaling by Hippo	R-HSA-2028269	2.750942e-05	4.561
Apoptosis	R-HSA-109581	3.033247e-05	4.518
Signal Transduction	R-HSA-162582	3.504133e-05	4.455
Cell Cycle, Mitotic	R-HSA-69278	5.043711e-05	4.297
Co-inhibition by CTLA4	R-HSA-389513	6.103410e-05	4.214
Co-stimulation by CD28	R-HSA-389356	7.676444e-05	4.115
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.593833e-05	4.120
FLT3 signaling through SRC family kinases	R-HSA-9706374	9.488923e-05	4.023
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.072845e-04	3.969
M Phase	R-HSA-68886	1.130413e-04	3.947
Programmed Cell Death	R-HSA-5357801	2.146507e-04	3.668
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.328970e-04	3.633
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.823811e-04	3.549
Signaling by NTRKs	R-HSA-166520	2.984135e-04	3.525
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.284957e-04	3.483
Signaling by Interleukins	R-HSA-449147	3.866751e-04	3.413
Nef and signal transduction	R-HSA-164944	4.389378e-04	3.358
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.694830e-04	3.245
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.150428e-04	3.211
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.492429e-04	3.188
Regulation of KIT signaling	R-HSA-1433559	7.163685e-04	3.145
Mitotic Prophase	R-HSA-68875	8.176156e-04	3.087
DCC mediated attractive signaling	R-HSA-418885	9.100431e-04	3.041
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.860583e-04	3.006
EPHB-mediated forward signaling	R-HSA-3928662	1.022639e-03	2.990
Nuclear Envelope Breakdown	R-HSA-2980766	1.053794e-03	2.977
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.170710e-03	2.932
Neurodegenerative Diseases	R-HSA-8863678	1.170710e-03	2.932
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.158495e-03	2.936
Signaling by VEGF	R-HSA-194138	1.230307e-03	2.910
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.332077e-03	2.875
Signaling by ERBB2	R-HSA-1227986	1.432285e-03	2.844
Recycling pathway of L1	R-HSA-437239	1.451959e-03	2.838
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.525370e-03	2.817
Regulation of CDH11 function	R-HSA-9762292	1.695144e-03	2.771
Interleukin-12 signaling	R-HSA-9020591	1.734060e-03	2.761
Semaphorin interactions	R-HSA-373755	1.913138e-03	2.718
Ephrin signaling	R-HSA-3928664	2.090003e-03	2.680
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.206322e-03	2.656
Mitotic Anaphase	R-HSA-68882	2.275759e-03	2.643
MAPK family signaling cascades	R-HSA-5683057	2.350594e-03	2.629
Cytokine Signaling in Immune system	R-HSA-1280215	2.264812e-03	2.645
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.382508e-03	2.623
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.483519e-03	2.605
Regulation of signaling by CBL	R-HSA-912631	2.506981e-03	2.601
Developmental Biology	R-HSA-1266738	2.761189e-03	2.559
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.786755e-03	2.555
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.830760e-03	2.548
Host Interactions of HIV factors	R-HSA-162909	3.000246e-03	2.523
Signaling by LTK	R-HSA-9842663	3.557106e-03	2.449
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.772381e-03	2.423
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.772381e-03	2.423
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.024693e-03	2.395
CD28 dependent Vav1 pathway	R-HSA-389359	4.400573e-03	2.356
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.250746e-03	2.372
Interleukin-12 family signaling	R-HSA-447115	4.424578e-03	2.354
RAF/MAP kinase cascade	R-HSA-5673001	4.632634e-03	2.334
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.794629e-03	2.319
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.790405e-03	2.320
L1CAM interactions	R-HSA-373760	4.978918e-03	2.303
Signaling by KIT in disease	R-HSA-9669938	4.790405e-03	2.320
ISG15 antiviral mechanism	R-HSA-1169408	5.255488e-03	2.279
RAF activation	R-HSA-5673000	5.387995e-03	2.269
PIP3 activates AKT signaling	R-HSA-1257604	5.746712e-03	2.241
MAPK1/MAPK3 signaling	R-HSA-5684996	5.952298e-03	2.225
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.556539e-03	2.183
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.465530e-03	2.189
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	6.622598e-03	2.179
Cohesin Loading onto Chromatin	R-HSA-2470946	6.966462e-03	2.157
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.966462e-03	2.157
Intracellular signaling by second messengers	R-HSA-9006925	7.439761e-03	2.128
Myogenesis	R-HSA-525793	8.261228e-03	2.083
Mitotic Prometaphase	R-HSA-68877	8.698513e-03	2.061
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	9.016964e-03	2.045
Signaling by MRAS-complex mutants	R-HSA-9660537	9.016964e-03	2.045
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.016964e-03	2.045
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.053200e-02	1.977
Regulation of TP53 Expression	R-HSA-6804754	1.053200e-02	1.977
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.053200e-02	1.977
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.053200e-02	1.977
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.053200e-02	1.977
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.344983e-03	2.029
Protein-protein interactions at synapses	R-HSA-6794362	1.054643e-02	1.977
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.138467e-02	1.944
ESR-mediated signaling	R-HSA-8939211	1.143140e-02	1.942
Separation of Sister Chromatids	R-HSA-2467813	1.166647e-02	1.933
Extra-nuclear estrogen signaling	R-HSA-9009391	1.218718e-02	1.914
Signaling by EGFR	R-HSA-177929	1.251430e-02	1.903
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.317502e-02	1.880
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.336693e-02	1.874
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.407752e-02	1.851
Signal attenuation	R-HSA-74749	1.407752e-02	1.851
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.465617e-02	1.834
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.465617e-02	1.834
G2/M DNA damage checkpoint	R-HSA-69473	1.475644e-02	1.831
Regulation of PTEN gene transcription	R-HSA-8943724	1.684775e-02	1.773
Netrin-1 signaling	R-HSA-373752	1.589054e-02	1.799
Interleukin-2 signaling	R-HSA-9020558	1.710112e-02	1.767
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.674708e-02	1.776
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.758196e-02	1.755
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.775601e-02	1.751
Signaling by ALK in cancer	R-HSA-9700206	1.775601e-02	1.751
IPs transport between nucleus and cytosol	R-HSA-1855170	1.794426e-02	1.746
Integrin signaling	R-HSA-354192	1.794426e-02	1.746
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.794426e-02	1.746
Viral Messenger RNA Synthesis	R-HSA-168325	1.807829e-02	1.743
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.045896e-02	1.689
Signaling by GSK3beta mutants	R-HSA-5339716	2.045896e-02	1.689
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.085184e-02	1.681
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.085184e-02	1.681
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.975698e-02	1.704
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.085184e-02	1.681
Signaling by FGFR2	R-HSA-5654738	2.140931e-02	1.669
Nuclear import of Rev protein	R-HSA-180746	2.168569e-02	1.664
GPER1 signaling	R-HSA-9634597	2.188820e-02	1.660
Regulation of gap junction activity	R-HSA-191650	2.254235e-02	1.647
Cell Cycle Checkpoints	R-HSA-69620	2.297167e-02	1.639
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.415263e-02	1.617
SHC-related events triggered by IGF1R	R-HSA-2428933	2.415263e-02	1.617
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.415263e-02	1.617
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.415263e-02	1.617
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.415263e-02	1.617
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.415263e-02	1.617
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.415263e-02	1.617
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.415263e-02	1.617
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.373280e-02	1.625
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.363286e-02	1.626
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.575510e-02	1.589
Degradation of CDH1	R-HSA-9766229	2.359681e-02	1.627
RUNX2 regulates bone development	R-HSA-8941326	2.590055e-02	1.587
Signaling by ROBO receptors	R-HSA-376176	2.601464e-02	1.585
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.687867e-02	1.571
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.818196e-02	1.550
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.819094e-02	1.550
Oncogenic MAPK signaling	R-HSA-6802957	2.838463e-02	1.547
IRS activation	R-HSA-74713	2.992946e-02	1.524
Retrograde neurotrophin signalling	R-HSA-177504	3.254524e-02	1.488
Deadenylation of mRNA	R-HSA-429947	2.911628e-02	1.536
mRNA 3'-end processing	R-HSA-72187	2.925198e-02	1.534
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.994791e-02	1.524
Amplification of signal from the kinetochores	R-HSA-141424	2.994791e-02	1.524
Mitotic Spindle Checkpoint	R-HSA-69618	2.888797e-02	1.539
Neurexins and neuroligins	R-HSA-6794361	2.925198e-02	1.534
HIV Infection	R-HSA-162906	3.064978e-02	1.514
Long-term potentiation	R-HSA-9620244	3.224460e-02	1.492
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.992946e-02	1.524
Oxidative Stress Induced Senescence	R-HSA-2559580	3.180254e-02	1.498
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.911628e-02	1.536
NrCAM interactions	R-HSA-447038	2.992946e-02	1.524
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.060582e-02	1.514
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.274201e-02	1.485
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.314680e-02	1.480
Loss of Function of TP53 in Cancer	R-HSA-9723907	3.747268e-02	1.426
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	3.747268e-02	1.426
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.813507e-02	1.419
Spry regulation of FGF signaling	R-HSA-1295596	3.723935e-02	1.429
Erythropoietin activates RAS	R-HSA-9027284	3.723935e-02	1.429
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.723935e-02	1.429
Beta-catenin phosphorylation cascade	R-HSA-196299	3.723935e-02	1.429
Transcriptional Regulation by TP53	R-HSA-3700989	3.628964e-02	1.440
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.813507e-02	1.419
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.813507e-02	1.419
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.813507e-02	1.419
Diseases of programmed cell death	R-HSA-9645723	3.499026e-02	1.456
Transcriptional regulation by small RNAs	R-HSA-5578749	3.598563e-02	1.444
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.907006e-02	1.408
Cell-Cell communication	R-HSA-1500931	3.667162e-02	1.436
Estrogen-dependent gene expression	R-HSA-9018519	3.574987e-02	1.447
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.813507e-02	1.419
Interactions of Rev with host cellular proteins	R-HSA-177243	3.581530e-02	1.446
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.581530e-02	1.446
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.861253e-02	1.413
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.808038e-02	1.419
FLT3 Signaling	R-HSA-9607240	3.861253e-02	1.413
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.035908e-02	1.394
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.035908e-02	1.394
Regulation of CDH1 Function	R-HSA-9764561	4.052548e-02	1.392
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.165387e-02	1.380
Leishmania phagocytosis	R-HSA-9664417	4.165387e-02	1.380
Parasite infection	R-HSA-9664407	4.165387e-02	1.380
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.276838e-02	1.369
Cellular Senescence	R-HSA-2559583	4.538164e-02	1.343
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.549350e-02	1.342
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.570778e-02	1.340
snRNP Assembly	R-HSA-191859	4.570778e-02	1.340
Metabolism of non-coding RNA	R-HSA-194441	4.570778e-02	1.340
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.665715e-02	1.331
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.665715e-02	1.331
Erythropoietin activates STAT5	R-HSA-9027283	4.708768e-02	1.327
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.708768e-02	1.327
TCR signaling	R-HSA-202403	4.744326e-02	1.324
Regulation of PTEN localization	R-HSA-8948747	5.671998e-02	1.246
SOS-mediated signalling	R-HSA-112412	5.671998e-02	1.246
DAP12 signaling	R-HSA-2424491	5.073587e-02	1.295
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.725871e-02	1.242
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.725871e-02	1.242
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.671998e-02	1.246
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.671998e-02	1.246
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.455791e-02	1.263
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.325725e-02	1.274
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.579314e-02	1.253
Cation-coupled Chloride cotransporters	R-HSA-426117	5.671998e-02	1.246
Phase 3 - rapid repolarisation	R-HSA-5576890	5.671998e-02	1.246
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.455791e-02	1.263
RNA Polymerase II Transcription Termination	R-HSA-73856	5.128419e-02	1.290
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.725871e-02	1.242
Signaling by SCF-KIT	R-HSA-1433557	4.778568e-02	1.321
Uptake and function of diphtheria toxin	R-HSA-5336415	5.671998e-02	1.246
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.459077e-02	1.263
Signaling by FGFR4	R-HSA-5654743	4.778568e-02	1.321
Signaling by FGFR3	R-HSA-5654741	5.455791e-02	1.263
G2/M Transition	R-HSA-69275	5.475493e-02	1.262
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.778568e-02	1.321
Processing of DNA double-strand break ends	R-HSA-5693607	5.727014e-02	1.242
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.814169e-02	1.236
Mitotic G2-G2/M phases	R-HSA-453274	5.815184e-02	1.235
Signaling by TGF-beta Receptor Complex	R-HSA-170834	5.827753e-02	1.234
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.922019e-02	1.228
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.922019e-02	1.228
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.922019e-02	1.228
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	5.945916e-02	1.226
Metabolism of RNA	R-HSA-8953854	6.077138e-02	1.216
Signaling by FGFR	R-HSA-190236	6.078505e-02	1.216
Platelet activation, signaling and aggregation	R-HSA-76002	6.296264e-02	1.201
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.410076e-02	1.193
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.410076e-02	1.193
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.570372e-02	1.182
Glycolysis	R-HSA-70171	6.600055e-02	1.180
Activated NTRK2 signals through FYN	R-HSA-9032500	6.696862e-02	1.174
Type I hemidesmosome assembly	R-HSA-446107	6.696862e-02	1.174
Downregulation of ERBB4 signaling	R-HSA-1253288	6.696862e-02	1.174
AURKA Activation by TPX2	R-HSA-8854518	6.697151e-02	1.174
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	7.354335e-02	1.133
Drug-mediated inhibition of MET activation	R-HSA-9734091	7.354335e-02	1.133
Diseases of Telomere Maintenance	R-HSA-9673013	7.354335e-02	1.133
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	7.354335e-02	1.133
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	7.354335e-02	1.133
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	7.354335e-02	1.133
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	7.354335e-02	1.133
ARMS-mediated activation	R-HSA-170984	7.777406e-02	1.109
Regulated proteolysis of p75NTR	R-HSA-193692	7.777406e-02	1.109
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.203391e-02	1.142
mRNA Splicing - Major Pathway	R-HSA-72163	6.918478e-02	1.160
PTEN Regulation	R-HSA-6807070	8.005844e-02	1.097
Activation and oligomerization of BAK protein	R-HSA-111452	7.354335e-02	1.133
DNA Double Strand Break Response	R-HSA-5693606	7.040957e-02	1.152
Signalling to ERKs	R-HSA-187687	7.912024e-02	1.102
DNA Double-Strand Break Repair	R-HSA-5693532	6.752033e-02	1.171
Homology Directed Repair	R-HSA-5693538	7.000856e-02	1.155
Activation, translocation and oligomerization of BAX	R-HSA-114294	7.354335e-02	1.133
Cellular response to heat stress	R-HSA-3371556	7.789087e-02	1.109
Oncogene Induced Senescence	R-HSA-2559585	7.912024e-02	1.102
GP1b-IX-V activation signalling	R-HSA-430116	7.777406e-02	1.109
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.777406e-02	1.109
Response of endothelial cells to shear stress	R-HSA-9860931	7.723813e-02	1.112
Post NMDA receptor activation events	R-HSA-438064	7.827769e-02	1.106
Cellular responses to stimuli	R-HSA-8953897	8.425409e-02	1.074
Zygotic genome activation (ZGA)	R-HSA-9819196	7.886647e-02	1.103
NPAS4 regulates expression of target genes	R-HSA-9768919	7.393381e-02	1.131
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.394762e-02	1.131
RET signaling	R-HSA-8853659	8.448277e-02	1.073
GPVI-mediated activation cascade	R-HSA-114604	8.448277e-02	1.073
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.528012e-02	1.069
Listeria monocytogenes entry into host cells	R-HSA-8876384	8.596981e-02	1.066
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.596981e-02	1.066
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.596981e-02	1.066
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.596981e-02	1.066
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	8.596981e-02	1.066
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.596981e-02	1.066
Immune System	R-HSA-168256	8.735956e-02	1.059
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.908034e-02	1.050
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	8.908034e-02	1.050
PI3K/AKT activation	R-HSA-198203	8.908034e-02	1.050
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.908034e-02	1.050
Signaling by Leptin	R-HSA-2586552	8.908034e-02	1.050
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.909245e-02	1.050
Gene Silencing by RNA	R-HSA-211000	8.955367e-02	1.048
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	1.082644e-01	0.966
NFG and proNGF binds to p75NTR	R-HSA-205017	1.082644e-01	0.966
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.082644e-01	0.966
PTEN Loss of Function in Cancer	R-HSA-5674404	1.082644e-01	0.966
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	1.082644e-01	0.966
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.082644e-01	0.966
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.082644e-01	0.966
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	1.082644e-01	0.966
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.082644e-01	0.966
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.082644e-01	0.966
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.008349e-01	0.996
Activated NTRK3 signals through RAS	R-HSA-9034864	1.008349e-01	0.996
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.008349e-01	0.996
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.008349e-01	0.996
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.008349e-01	0.996
Activated NTRK2 signals through RAS	R-HSA-9026519	1.129883e-01	0.947
FGFR2 alternative splicing	R-HSA-6803529	9.333363e-02	1.030
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.312411e-02	1.031
Centrosome maturation	R-HSA-380287	1.014769e-01	0.994
mRNA Splicing	R-HSA-72172	9.278243e-02	1.033
ATP-dependent chromatin remodelers	R-HSA-9932444	1.168803e-01	0.932
SWI/SNF chromatin remodelers	R-HSA-9932451	1.168803e-01	0.932
Sema4D in semaphorin signaling	R-HSA-400685	1.168803e-01	0.932
FCGR activation	R-HSA-2029481	1.032165e-01	0.986
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.280041e-02	1.032
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.087999e-01	0.963
PKMTs methylate histone lysines	R-HSA-3214841	1.138148e-01	0.944
Dectin-2 family	R-HSA-5621480	1.060844e-01	0.974
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.138148e-01	0.944
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.015932e-01	0.993
Manipulation of host energy metabolism	R-HSA-9636667	1.082644e-01	0.966
Ionotropic activity of kainate receptors	R-HSA-451306	1.008349e-01	0.996
Signaling by APC mutants	R-HSA-4839744	1.008349e-01	0.996
Signaling by AMER1 mutants	R-HSA-4839748	1.129883e-01	0.947
Signaling by AXIN mutants	R-HSA-4839735	1.129883e-01	0.947
Notch-HLH transcription pathway	R-HSA-350054	9.333363e-02	1.030
Deadenylation-dependent mRNA decay	R-HSA-429914	1.164047e-01	0.934
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.070942e-01	0.970
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.011010e-01	0.995
Chromatin organization	R-HSA-4839726	9.667198e-02	1.015
Transcriptional Regulation by VENTX	R-HSA-8853884	1.138148e-01	0.944
G2/M Checkpoints	R-HSA-69481	9.830517e-02	1.007
Negative regulation of MAPK pathway	R-HSA-5675221	1.201575e-01	0.920
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.521593e-02	1.021
Chromatin modifying enzymes	R-HSA-3247509	1.129644e-01	0.947
Breakdown of the nuclear lamina	R-HSA-352238	1.082644e-01	0.966
Signaling by FGFR1	R-HSA-5654736	1.011010e-01	0.995
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.201575e-01	0.920
Generation of second messenger molecules	R-HSA-202433	1.076252e-01	0.968
C-type lectin receptors (CLRs)	R-HSA-5621481	1.164330e-01	0.934
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.333363e-02	1.030
Cell junction organization	R-HSA-446728	1.122918e-01	0.950
Transcriptional regulation by RUNX1	R-HSA-8878171	9.387289e-02	1.027
Activation of RAC1	R-HSA-428540	1.129883e-01	0.947
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	1.015932e-01	0.993
Cellular responses to mechanical stimuli	R-HSA-9855142	1.136722e-01	0.944
Formation of the nephric duct	R-HSA-9830364	1.168803e-01	0.932
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.572287e-02	1.019
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.009473e-01	0.996
Inositol phosphate metabolism	R-HSA-1483249	1.064522e-01	0.973
Sensory processing of sound	R-HSA-9659379	1.193128e-01	0.923
Signaling by ALK	R-HSA-201556	1.015932e-01	0.993
MITF-M-dependent gene expression	R-HSA-9856651	1.144148e-01	0.942
Growth hormone receptor signaling	R-HSA-982772	1.009473e-01	0.996
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.211503e-01	0.917
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	1.416862e-01	0.849
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.416862e-01	0.849
Defective visual phototransduction due to STRA6 loss of function	R-HSA-9918449	1.416862e-01	0.849
MET interacts with TNS proteins	R-HSA-8875513	1.738574e-01	0.760
Axonal growth stimulation	R-HSA-209563	1.738574e-01	0.760
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.738574e-01	0.760
MET activates PTPN11	R-HSA-8865999	1.738574e-01	0.760
Invadopodia formation	R-HSA-8941237	1.738574e-01	0.760
Defective ABCC2 causes DJS	R-HSA-5679001	1.738574e-01	0.760
NADE modulates death signalling	R-HSA-205025	2.048246e-01	0.689
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.048246e-01	0.689
Nucleotide catabolism defects	R-HSA-9735786	2.048246e-01	0.689
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.048246e-01	0.689
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.048246e-01	0.689
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.346328e-01	0.630
NTRK2 activates RAC1	R-HSA-9032759	2.346328e-01	0.630
MET activates RAS signaling	R-HSA-8851805	1.254944e-01	0.901
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.254944e-01	0.901
Plus-strand DNA synthesis	R-HSA-164525	2.633254e-01	0.580
Nef Mediated CD8 Down-regulation	R-HSA-182218	2.633254e-01	0.580
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.633254e-01	0.580
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.633254e-01	0.580
Adenylate cyclase activating pathway	R-HSA-170660	1.383098e-01	0.859
CRMPs in Sema3A signaling	R-HSA-399956	1.513938e-01	0.820
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	2.909441e-01	0.536
Uncoating of the HIV Virion	R-HSA-162585	2.909441e-01	0.536
Defective CHST6 causes MCDC1	R-HSA-3656225	2.909441e-01	0.536
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	2.909441e-01	0.536
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	2.909441e-01	0.536
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	2.909441e-01	0.536
Defective CHST3 causes SEDCJD	R-HSA-3595172	2.909441e-01	0.536
Adenylate cyclase inhibitory pathway	R-HSA-170670	1.647083e-01	0.783
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.782179e-01	0.749
Defective GALNT12 causes CRCS1	R-HSA-5083636	1.782179e-01	0.749
Defective GALNT3 causes HFTC	R-HSA-5083625	1.782179e-01	0.749
RUNX3 regulates WNT signaling	R-HSA-8951430	3.175289e-01	0.498
MET activates PI3K/AKT signaling	R-HSA-8851907	3.175289e-01	0.498
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.175289e-01	0.498
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.175289e-01	0.498
IFNG signaling activates MAPKs	R-HSA-9732724	3.175289e-01	0.498
Defective CHSY1 causes TPBS	R-HSA-3595177	3.175289e-01	0.498
MET activates PTK2 signaling	R-HSA-8874081	1.251772e-01	0.902
RNA Polymerase I Transcription Termination	R-HSA-73863	1.336793e-01	0.874
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.056913e-01	0.687
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.056913e-01	0.687
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.056913e-01	0.687
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	2.056913e-01	0.687
Reverse Transcription of HIV RNA	R-HSA-162589	3.431185e-01	0.465
Minus-strand DNA synthesis	R-HSA-164516	3.431185e-01	0.465
MET receptor recycling	R-HSA-8875656	3.431185e-01	0.465
Formation of annular gap junctions	R-HSA-196025	3.431185e-01	0.465
Signaling by Erythropoietin	R-HSA-9006335	1.512531e-01	0.820
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.512531e-01	0.820
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.603020e-01	0.795
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.335740e-01	0.632
Gap junction degradation	R-HSA-190873	3.677501e-01	0.434
ALK mutants bind TKIs	R-HSA-9700645	3.677501e-01	0.434
Negative regulation of MET activity	R-HSA-6807004	2.476025e-01	0.606
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.616574e-01	0.582
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.616574e-01	0.582
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.616574e-01	0.582
Striated Muscle Contraction	R-HSA-390522	1.979802e-01	0.703
mRNA Splicing - Minor Pathway	R-HSA-72165	1.540057e-01	0.812
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.757172e-01	0.560
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.077150e-01	0.683
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.037724e-01	0.517
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.037724e-01	0.517
Termination of O-glycan biosynthesis	R-HSA-977068	3.037724e-01	0.517
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.375052e-01	0.624
Formation of RNA Pol II elongation complex	R-HSA-112382	1.986581e-01	0.702
RNA Polymerase I Promoter Escape	R-HSA-73772	1.986581e-01	0.702
MET promotes cell motility	R-HSA-8875878	2.475964e-01	0.606
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.177321e-01	0.498
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.177321e-01	0.498
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	3.177321e-01	0.498
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.064546e-01	0.685
Meiotic synapsis	R-HSA-1221632	2.064546e-01	0.685
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.679618e-01	0.572
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.679618e-01	0.572
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.872157e-01	0.728
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.700067e-01	0.770
Signaling by RAF1 mutants	R-HSA-9656223	2.885092e-01	0.540
SHC-mediated cascade:FGFR2	R-HSA-5654699	3.591531e-01	0.445
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.591531e-01	0.445
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.591531e-01	0.445
GABA B receptor activation	R-HSA-977444	2.988289e-01	0.525
Activation of GABAB receptors	R-HSA-991365	2.988289e-01	0.525
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.631667e-01	0.580
Nucleosome assembly	R-HSA-774815	3.298724e-01	0.482
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.298724e-01	0.482
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.402222e-01	0.468
Signaling downstream of RAS mutants	R-HSA-9649948	3.402222e-01	0.468
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.402222e-01	0.468
Regulation of endogenous retroelements	R-HSA-9842860	2.655401e-01	0.576
Neutrophil degranulation	R-HSA-6798695	2.157601e-01	0.666
Signaling by EGFR in Cancer	R-HSA-1643713	3.454365e-01	0.462
Formation of definitive endoderm	R-HSA-9823730	2.476025e-01	0.606
Signaling by MET	R-HSA-6806834	2.482476e-01	0.605
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.383098e-01	0.859
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.810885e-01	0.742
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.987515e-01	0.525
p75NTR regulates axonogenesis	R-HSA-193697	3.677501e-01	0.434
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.651930e-01	0.437
NoRC negatively regulates rRNA expression	R-HSA-427413	1.872157e-01	0.728
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	3.591531e-01	0.445
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.431185e-01	0.465
MAP2K and MAPK activation	R-HSA-5674135	2.885092e-01	0.540
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.303446e-01	0.638
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.346328e-01	0.630
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.336793e-01	0.874
Condensation of Prophase Chromosomes	R-HSA-2299718	1.540057e-01	0.812
Attenuation phase	R-HSA-3371568	2.679618e-01	0.572
Chaperone Mediated Autophagy	R-HSA-9613829	2.195952e-01	0.658
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.423751e-01	0.847
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.512531e-01	0.820
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.077150e-01	0.683
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.897617e-01	0.538
RNA Polymerase I Transcription	R-HSA-73864	2.342370e-01	0.630
Signaling by RAS mutants	R-HSA-6802949	3.402222e-01	0.468
Translesion Synthesis by POLH	R-HSA-110320	2.335740e-01	0.632
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.677501e-01	0.434
Lysosome Vesicle Biogenesis	R-HSA-432720	2.274879e-01	0.643
TRAF6 mediated NF-kB activation	R-HSA-933542	3.177321e-01	0.498
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.482476e-01	0.605
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.883605e-01	0.725
Germ layer formation at gastrulation	R-HSA-9754189	2.335740e-01	0.632
Epigenetic regulation of gene expression	R-HSA-212165	1.694539e-01	0.771
IGF1R signaling cascade	R-HSA-2428924	1.441634e-01	0.841
Signalling to RAS	R-HSA-167044	2.616574e-01	0.582
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.327363e-01	0.877
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.577518e-01	0.589
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.204606e-01	0.657
Regulation of TP53 Activity	R-HSA-5633007	1.484663e-01	0.828
Meiosis	R-HSA-1500620	2.841269e-01	0.546
Clathrin-mediated endocytosis	R-HSA-8856828	2.761506e-01	0.559
HIV Life Cycle	R-HSA-162587	2.297866e-01	0.639
Tight junction interactions	R-HSA-420029	3.316250e-01	0.479
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.782173e-01	0.556
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.988289e-01	0.525
Late Phase of HIV Life Cycle	R-HSA-162599	1.633856e-01	0.787
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.603020e-01	0.795
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.002925e-01	0.698
Prolonged ERK activation events	R-HSA-169893	1.782179e-01	0.749
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.500310e-01	0.824
Downstream TCR signaling	R-HSA-202424	3.283282e-01	0.484
Nephrin family interactions	R-HSA-373753	2.476025e-01	0.606
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.454365e-01	0.462
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.048246e-01	0.689
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.048246e-01	0.689
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.513938e-01	0.820
MET Receptor Activation	R-HSA-6806942	2.909441e-01	0.536
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.454365e-01	0.462
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.644091e-01	0.438
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.223425e-01	0.492
Chromosome Maintenance	R-HSA-73886	1.492891e-01	0.826
NRIF signals cell death from the nucleus	R-HSA-205043	1.513938e-01	0.820
HSF1 activation	R-HSA-3371511	2.274879e-01	0.643
NRAGE signals death through JNK	R-HSA-193648	2.303446e-01	0.638
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.077150e-01	0.683
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.918892e-01	0.717
Regulation of PTEN mRNA translation	R-HSA-8943723	3.037724e-01	0.517
Telomere Maintenance	R-HSA-157579	2.341749e-01	0.630
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.480398e-01	0.458
DAP12 interactions	R-HSA-2172127	1.400587e-01	0.854
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.416862e-01	0.849
MET activates STAT3	R-HSA-8875791	1.738574e-01	0.760
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.048246e-01	0.689
VLDLR internalisation and degradation	R-HSA-8866427	1.254944e-01	0.901
Ceramide signalling	R-HSA-193681	2.633254e-01	0.580
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.633254e-01	0.580
Noncanonical activation of NOTCH3	R-HSA-9017802	2.633254e-01	0.580
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.782179e-01	0.749
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.175289e-01	0.498
Disinhibition of SNARE formation	R-HSA-114516	3.175289e-01	0.498
PKA activation in glucagon signalling	R-HSA-164378	2.195952e-01	0.658
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.335740e-01	0.632
Inactivation of CDC42 and RAC1	R-HSA-428543	3.677501e-01	0.434
Trafficking of AMPA receptors	R-HSA-399719	1.695104e-01	0.771
Signaling by WNT in cancer	R-HSA-4791275	1.788669e-01	0.747
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.077150e-01	0.683
Gene expression (Transcription)	R-HSA-74160	1.490669e-01	0.827
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.512531e-01	0.820
Regulation of TP53 Degradation	R-HSA-6804757	2.274879e-01	0.643
Gap junction trafficking and regulation	R-HSA-157858	1.758441e-01	0.755
RNA Polymerase II Transcription	R-HSA-73857	2.534808e-01	0.596
Hedgehog 'off' state	R-HSA-5610787	2.528602e-01	0.597
Signaling by TGFB family members	R-HSA-9006936	2.441452e-01	0.612
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.346328e-01	0.630
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.476025e-01	0.606
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.308430e-01	0.883
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	3.596721e-01	0.444
Somitogenesis	R-HSA-9824272	1.469676e-01	0.833
Adrenoceptors	R-HSA-390696	3.431185e-01	0.465
Formation of paraxial mesoderm	R-HSA-9793380	2.715102e-01	0.566
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.048246e-01	0.689
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.782179e-01	0.749
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.175289e-01	0.498
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.677501e-01	0.434
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.677501e-01	0.434
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.475964e-01	0.606
Aggrephagy	R-HSA-9646399	2.679618e-01	0.572
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.480398e-01	0.458
mTORC1-mediated signalling	R-HSA-166208	2.897617e-01	0.538
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	1.251772e-01	0.902
Downregulation of ERBB2 signaling	R-HSA-8863795	1.603020e-01	0.795
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.453686e-01	0.838
Regulation of T cell activation by CD28 family	R-HSA-388841	2.609527e-01	0.583
Adaptive Immune System	R-HSA-1280218	1.747021e-01	0.758
Intracellular oxygen transport	R-HSA-8981607	1.738574e-01	0.760
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.048246e-01	0.689
Inositol transporters	R-HSA-429593	2.346328e-01	0.630
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.346328e-01	0.630
Signalling to p38 via RIT and RIN	R-HSA-187706	2.633254e-01	0.580
TGFBR3 PTM regulation	R-HSA-9839383	3.431185e-01	0.465
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.431185e-01	0.465
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.677501e-01	0.434
Calcineurin activates NFAT	R-HSA-2025928	3.677501e-01	0.434
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.822039e-01	0.739
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.453686e-01	0.838
Intra-Golgi traffic	R-HSA-6811438	2.885092e-01	0.540
Ub-specific processing proteases	R-HSA-5689880	2.036798e-01	0.691
G1 Phase	R-HSA-69236	1.400587e-01	0.854
Cyclin D associated events in G1	R-HSA-69231	1.400587e-01	0.854
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.505608e-01	0.455
Transmission across Chemical Synapses	R-HSA-112315	3.340816e-01	0.476
Neuronal System	R-HSA-112316	2.468315e-01	0.608
Signaling by ERBB4	R-HSA-1236394	2.069447e-01	0.684
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.909441e-01	0.536
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.336793e-01	0.874
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.883605e-01	0.725
ERK/MAPK targets	R-HSA-198753	2.616574e-01	0.582
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.175544e-01	0.662
Signaling by FGFR1 in disease	R-HSA-5655302	2.885092e-01	0.540
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.138361e-01	0.670
FGFR1 mutant receptor activation	R-HSA-1839124	1.883605e-01	0.725
Transcriptional Regulation by E2F6	R-HSA-8953750	2.577518e-01	0.589
Platelet degranulation	R-HSA-114608	3.015435e-01	0.521
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.043584e-01	0.690
Interleukin-2 family signaling	R-HSA-451927	2.679618e-01	0.572
Activation of BH3-only proteins	R-HSA-114452	1.603020e-01	0.795
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.469676e-01	0.833
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.036798e-01	0.691
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.036798e-01	0.691
Cell-cell junction organization	R-HSA-421270	2.412939e-01	0.617
The NLRP1 inflammasome	R-HSA-844455	1.738574e-01	0.760
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.346328e-01	0.630
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.346328e-01	0.630
Reelin signalling pathway	R-HSA-8866376	2.346328e-01	0.630
Release of apoptotic factors from the mitochondria	R-HSA-111457	2.633254e-01	0.580
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.633254e-01	0.580
Platelet Adhesion to exposed collagen	R-HSA-75892	1.383098e-01	0.859
Netrin mediated repulsion signals	R-HSA-418886	3.175289e-01	0.498
PKA activation	R-HSA-163615	2.195952e-01	0.658
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.512531e-01	0.820
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.677501e-01	0.434
Adherens junctions interactions	R-HSA-418990	3.038724e-01	0.517
Parasitic Infection Pathways	R-HSA-9824443	1.824369e-01	0.739
Leishmania infection	R-HSA-9658195	1.824369e-01	0.739
Nuclear signaling by ERBB4	R-HSA-1251985	2.679618e-01	0.572
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.790288e-01	0.747
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	3.316250e-01	0.479
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.482476e-01	0.605
Signaling by Nuclear Receptors	R-HSA-9006931	1.525667e-01	0.817
Leishmania parasite growth and survival	R-HSA-9664433	3.146679e-01	0.502
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	3.146679e-01	0.502
Cellular responses to stress	R-HSA-2262752	1.690724e-01	0.772
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.883605e-01	0.725
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.175544e-01	0.662
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.979802e-01	0.703
Innate Immune System	R-HSA-168249	2.330674e-01	0.633
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.633254e-01	0.580
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.633254e-01	0.580
Leukotriene receptors	R-HSA-391906	2.909441e-01	0.536
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.647083e-01	0.783
Synthesis of PG	R-HSA-1483148	1.918892e-01	0.717
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.677501e-01	0.434
Respiratory syncytial virus genome replication	R-HSA-9834752	3.677501e-01	0.434
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.677501e-01	0.434
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.616574e-01	0.582
Syndecan interactions	R-HSA-3000170	3.037724e-01	0.517
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.276245e-01	0.894
MAPK6/MAPK4 signaling	R-HSA-5687128	2.841269e-01	0.546
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.276245e-01	0.894
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.276245e-01	0.894
MAP kinase activation	R-HSA-450294	2.715102e-01	0.566
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.840886e-01	0.735
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.489607e-01	0.604
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.242843e-01	0.489
GAB1 signalosome	R-HSA-180292	2.195952e-01	0.658
RMTs methylate histone arginines	R-HSA-3214858	3.195185e-01	0.496
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.489607e-01	0.604
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.661884e-01	0.575
MyD88-independent TLR4 cascade	R-HSA-166166	3.242843e-01	0.489
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.913535e-01	0.536
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.661884e-01	0.575
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.475964e-01	0.606
Interleukin-17 signaling	R-HSA-448424	3.480398e-01	0.458
Influenza Infection	R-HSA-168255	1.418096e-01	0.848
Cell surface interactions at the vascular wall	R-HSA-202733	2.813486e-01	0.551
PI Metabolism	R-HSA-1483255	1.453686e-01	0.838
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.383098e-01	0.859
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.782179e-01	0.749
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.677501e-01	0.434
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.883605e-01	0.725
Signaling by PDGFR in disease	R-HSA-9671555	2.757172e-01	0.560
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.316250e-01	0.479
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.049010e-01	0.688
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.480398e-01	0.458
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.034820e-01	0.518
LDL clearance	R-HSA-8964038	2.897617e-01	0.538
Glucose metabolism	R-HSA-70326	1.328419e-01	0.877
Diseases of DNA repair	R-HSA-9675135	3.402222e-01	0.468
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.677501e-01	0.434
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.616574e-01	0.582
tRNA processing in the nucleus	R-HSA-6784531	1.327363e-01	0.877
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.020747e-01	0.694
Laminin interactions	R-HSA-3000157	3.316250e-01	0.479
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	3.316250e-01	0.479
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.492891e-01	0.826
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.707665e-01	0.567
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.175289e-01	0.498
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.918892e-01	0.717
Synaptic adhesion-like molecules	R-HSA-8849932	2.195952e-01	0.658
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.553326e-01	0.593
Toll-like Receptor Cascades	R-HSA-168898	2.850865e-01	0.545
Platelet sensitization by LDL	R-HSA-432142	2.195952e-01	0.658
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.037724e-01	0.517
Signaling by FGFR in disease	R-HSA-1226099	2.069447e-01	0.684
Transcriptional Regulation by NPAS4	R-HSA-9634815	1.986581e-01	0.702
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.651930e-01	0.437
Signal regulatory protein family interactions	R-HSA-391160	1.513938e-01	0.820
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.631667e-01	0.580
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.631667e-01	0.580
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.631667e-01	0.580
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.631667e-01	0.580
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.883605e-01	0.725
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.454365e-01	0.462
Transcriptional Regulation by MECP2	R-HSA-8986944	3.357725e-01	0.474
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.591531e-01	0.445
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.631667e-01	0.580
Interleukin-7 signaling	R-HSA-1266695	3.316250e-01	0.479
DNA Damage Bypass	R-HSA-73893	3.711763e-01	0.430
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.711763e-01	0.430
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.727627e-01	0.429
HIV elongation arrest and recovery	R-HSA-167287	3.727627e-01	0.429
Formation of the Early Elongation Complex	R-HSA-113418	3.727627e-01	0.429
Pausing and recovery of HIV elongation	R-HSA-167290	3.727627e-01	0.429
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.727627e-01	0.429
Activation of kainate receptors upon glutamate binding	R-HSA-451326	3.727627e-01	0.429
Inflammasomes	R-HSA-622312	3.727627e-01	0.429
Pyroptosis	R-HSA-5620971	3.727627e-01	0.429
DNA Repair	R-HSA-73894	3.815400e-01	0.418
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.823246e-01	0.418
Mitochondrial biogenesis	R-HSA-1592230	3.845854e-01	0.415
DNA methylation	R-HSA-5334118	3.862540e-01	0.413
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.862540e-01	0.413
mRNA Capping	R-HSA-72086	3.862540e-01	0.413
Downstream signaling of activated FGFR3	R-HSA-5654708	3.862540e-01	0.413
DARPP-32 events	R-HSA-180024	3.862540e-01	0.413
Unfolded Protein Response (UPR)	R-HSA-381119	3.869004e-01	0.412
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.881139e-01	0.411
Binding and entry of HIV virion	R-HSA-173107	3.914595e-01	0.407
MET activates RAP1 and RAC1	R-HSA-8875555	3.914595e-01	0.407
Apoptosis induced DNA fragmentation	R-HSA-140342	3.914595e-01	0.407
Formation of apoptosome	R-HSA-111458	3.914595e-01	0.407
Regulation of the apoptosome activity	R-HSA-9627069	3.914595e-01	0.407
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.914595e-01	0.407
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.914595e-01	0.407
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.914595e-01	0.407
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.914595e-01	0.407
Receptor Mediated Mitophagy	R-HSA-8934903	3.914595e-01	0.407
HSF1-dependent transactivation	R-HSA-3371571	3.916666e-01	0.407
Activation of NF-kappaB in B cells	R-HSA-1169091	3.916666e-01	0.407
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.942005e-01	0.404
Transcriptional regulation by RUNX3	R-HSA-8878159	3.955905e-01	0.403
Transcriptional regulation by RUNX2	R-HSA-8878166	3.980410e-01	0.400
MITF-M-regulated melanocyte development	R-HSA-9730414	3.991412e-01	0.399
Signaling by NOTCH1	R-HSA-1980143	3.994033e-01	0.399
Neurotransmitter clearance	R-HSA-112311	3.996167e-01	0.398
Downstream signaling of activated FGFR4	R-HSA-5654716	3.996167e-01	0.398
Interleukin-37 signaling	R-HSA-9008059	3.996167e-01	0.398
Post-translational protein phosphorylation	R-HSA-8957275	4.030589e-01	0.395
p75 NTR receptor-mediated signalling	R-HSA-193704	4.105165e-01	0.387
SLC transporter disorders	R-HSA-5619102	4.110928e-01	0.386
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.119840e-01	0.385
Regulation of PTEN stability and activity	R-HSA-8948751	4.119840e-01	0.385
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.119840e-01	0.385
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.128415e-01	0.384
Budding and maturation of HIV virion	R-HSA-162588	4.128415e-01	0.384
EGFR downregulation	R-HSA-182971	4.128415e-01	0.384
Downstream signal transduction	R-HSA-186763	4.128415e-01	0.384
RHOBTB3 ATPase cycle	R-HSA-9706019	4.142812e-01	0.383
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.142812e-01	0.383
vRNP Assembly	R-HSA-192905	4.142812e-01	0.383
Bicarbonate transporters	R-HSA-425381	4.142812e-01	0.383
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.142812e-01	0.383
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.142812e-01	0.383
PCP/CE pathway	R-HSA-4086400	4.163994e-01	0.380
Translation initiation complex formation	R-HSA-72649	4.220640e-01	0.375
MHC class II antigen presentation	R-HSA-2132295	4.248935e-01	0.372
Diseases of mitotic cell cycle	R-HSA-9675126	4.259201e-01	0.371
Formation of the cornified envelope	R-HSA-6809371	4.315836e-01	0.365
HDACs deacetylate histones	R-HSA-3214815	4.320849e-01	0.364
PKR-mediated signaling	R-HSA-9833482	4.332850e-01	0.363
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.362484e-01	0.360
DS-GAG biosynthesis	R-HSA-2022923	4.362484e-01	0.360
Synthesis of diphthamide-EEF2	R-HSA-5358493	4.362484e-01	0.360
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.362484e-01	0.360
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.362484e-01	0.360
Plasmalogen biosynthesis	R-HSA-75896	4.362484e-01	0.360
NF-kB is activated and signals survival	R-HSA-209560	4.362484e-01	0.360
ERKs are inactivated	R-HSA-202670	4.362484e-01	0.360
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.362484e-01	0.360
Integration of provirus	R-HSA-162592	4.362484e-01	0.360
HCMV Early Events	R-HSA-9609690	4.371029e-01	0.359
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	4.388447e-01	0.358
Activation of ATR in response to replication stress	R-HSA-176187	4.388447e-01	0.358
Cardiogenesis	R-HSA-9733709	4.388447e-01	0.358
Ribosomal scanning and start codon recognition	R-HSA-72702	4.420417e-01	0.355
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.475585e-01	0.349
S Phase	R-HSA-69242	4.483887e-01	0.348
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.516086e-01	0.345
Glucagon signaling in metabolic regulation	R-HSA-163359	4.516086e-01	0.345
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.519300e-01	0.345
p75NTR recruits signalling complexes	R-HSA-209543	4.573930e-01	0.340
Scavenging by Class F Receptors	R-HSA-3000484	4.573930e-01	0.340
Polymerase switching	R-HSA-69091	4.573930e-01	0.340
Leading Strand Synthesis	R-HSA-69109	4.573930e-01	0.340
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.573930e-01	0.340
Serotonin clearance from the synaptic cleft	R-HSA-380615	4.573930e-01	0.340
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.573930e-01	0.340
Interleukin-15 signaling	R-HSA-8983432	4.573930e-01	0.340
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.573930e-01	0.340
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.573930e-01	0.340
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.573930e-01	0.340
Disorders of Nervous System Development	R-HSA-9697154	4.573930e-01	0.340
Pervasive developmental disorders	R-HSA-9005895	4.573930e-01	0.340
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.573930e-01	0.340
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.573930e-01	0.340
Potential therapeutics for SARS	R-HSA-9679191	4.605835e-01	0.337
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.617455e-01	0.336
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.642057e-01	0.333
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.642057e-01	0.333
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.642057e-01	0.333
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.642057e-01	0.333
SARS-CoV-1-host interactions	R-HSA-9692914	4.695045e-01	0.328
Generic Transcription Pathway	R-HSA-212436	4.697775e-01	0.328
Extension of Telomeres	R-HSA-180786	4.714842e-01	0.327
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.743995e-01	0.324
SARS-CoV-2-host interactions	R-HSA-9705683	4.749454e-01	0.323
Regulation of Apoptosis	R-HSA-169911	4.766304e-01	0.322
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.766304e-01	0.322
Downstream signaling of activated FGFR2	R-HSA-5654696	4.766304e-01	0.322
Downstream signaling of activated FGFR1	R-HSA-5654687	4.766304e-01	0.322
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.777458e-01	0.321
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.777458e-01	0.321
Frs2-mediated activation	R-HSA-170968	4.777458e-01	0.321
Diseases of nucleotide metabolism	R-HSA-9735804	4.777458e-01	0.321
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.777458e-01	0.321
Formation of axial mesoderm	R-HSA-9796292	4.777458e-01	0.321
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	4.777458e-01	0.321
Deubiquitination	R-HSA-5688426	4.801301e-01	0.319
GABA receptor activation	R-HSA-977443	4.811423e-01	0.318
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.811423e-01	0.318
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.888781e-01	0.311
FLT3 signaling in disease	R-HSA-9682385	4.888781e-01	0.311
FGFR2 mutant receptor activation	R-HSA-1839126	4.888781e-01	0.311
Calmodulin induced events	R-HSA-111933	4.888781e-01	0.311
CaM pathway	R-HSA-111997	4.888781e-01	0.311
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.911555e-01	0.309
XBP1(S) activates chaperone genes	R-HSA-381038	4.911555e-01	0.309
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.973364e-01	0.303
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.973364e-01	0.303
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.973364e-01	0.303
HDL assembly	R-HSA-8963896	4.973364e-01	0.303
Zinc transporters	R-HSA-435354	4.973364e-01	0.303
Heme signaling	R-HSA-9707616	5.002026e-01	0.301
NCAM signaling for neurite out-growth	R-HSA-375165	5.002026e-01	0.301
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.002026e-01	0.301
Voltage gated Potassium channels	R-HSA-1296072	5.009445e-01	0.300
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.009445e-01	0.300
Ovarian tumor domain proteases	R-HSA-5689896	5.009445e-01	0.300
HCMV Late Events	R-HSA-9610379	5.027334e-01	0.299
Hemostasis	R-HSA-109582	5.069200e-01	0.295
Selective autophagy	R-HSA-9663891	5.072481e-01	0.295
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.095984e-01	0.293
Signaling by PTK6	R-HSA-8848021	5.095984e-01	0.293
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.125101e-01	0.290
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.125101e-01	0.290
FCERI mediated MAPK activation	R-HSA-2871796	5.125101e-01	0.290
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.161932e-01	0.287
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.161932e-01	0.287
SHC1 events in EGFR signaling	R-HSA-180336	5.161932e-01	0.287
RNA Polymerase III Chain Elongation	R-HSA-73780	5.161932e-01	0.287
p75NTR signals via NF-kB	R-HSA-193639	5.161932e-01	0.287
Translesion synthesis by REV1	R-HSA-110312	5.161932e-01	0.287
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.161932e-01	0.287
Lysosphingolipid and LPA receptors	R-HSA-419408	5.161932e-01	0.287
p38MAPK events	R-HSA-171007	5.161932e-01	0.287
Signaling by Activin	R-HSA-1502540	5.161932e-01	0.287
Dopamine clearance from the synaptic cleft	R-HSA-379401	5.161932e-01	0.287
Cell-extracellular matrix interactions	R-HSA-446353	5.161932e-01	0.287
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.161932e-01	0.287
Protein methylation	R-HSA-8876725	5.161932e-01	0.287
Disease	R-HSA-1643685	5.164832e-01	0.287
Insulin receptor signalling cascade	R-HSA-74751	5.189007e-01	0.285
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.189007e-01	0.285
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.245195e-01	0.280
Stabilization of p53	R-HSA-69541	5.245195e-01	0.280
Plasma lipoprotein clearance	R-HSA-8964043	5.245195e-01	0.280
Beta-catenin independent WNT signaling	R-HSA-3858494	5.295002e-01	0.276
SARS-CoV Infections	R-HSA-9679506	5.297664e-01	0.276
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	5.334730e-01	0.273
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.343437e-01	0.272
Translesion synthesis by POLI	R-HSA-5656121	5.343437e-01	0.272
Phosphorylation of the APC/C	R-HSA-176412	5.343437e-01	0.272
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	5.343437e-01	0.272
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.343437e-01	0.272
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.343437e-01	0.272
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.343437e-01	0.272
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.343437e-01	0.272
Regulation of NF-kappa B signaling	R-HSA-9758274	5.343437e-01	0.272
Negative regulation of FLT3	R-HSA-9706369	5.343437e-01	0.272
Atorvastatin ADME	R-HSA-9754706	5.343437e-01	0.272
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.360224e-01	0.271
HIV Transcription Elongation	R-HSA-167169	5.360224e-01	0.271
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.360224e-01	0.271
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.360224e-01	0.271
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.360224e-01	0.271
Organelle biogenesis and maintenance	R-HSA-1852241	5.364213e-01	0.270
IRE1alpha activates chaperones	R-HSA-381070	5.387227e-01	0.269
Cellular response to chemical stress	R-HSA-9711123	5.410927e-01	0.267
Ribosome-associated quality control	R-HSA-9948299	5.420624e-01	0.266
Signaling by Hedgehog	R-HSA-5358351	5.420624e-01	0.266
Kidney development	R-HSA-9830369	5.462204e-01	0.263
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.473325e-01	0.262
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.473325e-01	0.262
Maturation of spike protein	R-HSA-9694548	5.473325e-01	0.262
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.518144e-01	0.258
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.518144e-01	0.258
Translesion synthesis by POLK	R-HSA-5655862	5.518144e-01	0.258
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.518144e-01	0.258
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	5.518144e-01	0.258
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	5.518144e-01	0.258
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.518144e-01	0.258
Biosynthesis of maresin-like SPMs	R-HSA-9027307	5.518144e-01	0.258
Phase 2 - plateau phase	R-HSA-5576893	5.518144e-01	0.258
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.518144e-01	0.258
Fibronectin matrix formation	R-HSA-1566977	5.518144e-01	0.258
Disorders of Developmental Biology	R-HSA-9675151	5.518144e-01	0.258
Acetylcholine regulates insulin secretion	R-HSA-399997	5.518144e-01	0.258
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	5.540737e-01	0.256
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.551236e-01	0.256
Regulated Necrosis	R-HSA-5218859	5.551236e-01	0.256
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.584481e-01	0.253
HIV Transcription Initiation	R-HSA-167161	5.584481e-01	0.253
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.584481e-01	0.253
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.584481e-01	0.253
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.584481e-01	0.253
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.584481e-01	0.253
SLC-mediated transport of neurotransmitters	R-HSA-442660	5.584481e-01	0.253
Disorders of transmembrane transporters	R-HSA-5619115	5.677096e-01	0.246
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	5.686306e-01	0.245
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.686306e-01	0.245
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.686306e-01	0.245
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.686306e-01	0.245
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.686306e-01	0.245
Regulation of FZD by ubiquitination	R-HSA-4641263	5.686306e-01	0.245
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.693680e-01	0.245
Cleavage of the damaged pyrimidine	R-HSA-110329	5.693680e-01	0.245
Depyrimidination	R-HSA-73928	5.693680e-01	0.245
MTOR signalling	R-HSA-165159	5.693680e-01	0.245
Ca-dependent events	R-HSA-111996	5.693680e-01	0.245
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	5.765796e-01	0.239
Interferon Signaling	R-HSA-913531	5.794322e-01	0.237
RNA Polymerase II Promoter Escape	R-HSA-73776	5.800910e-01	0.237
Hedgehog 'on' state	R-HSA-5632684	5.811962e-01	0.236
ECM proteoglycans	R-HSA-3000178	5.811962e-01	0.236
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.833089e-01	0.234
tRNA processing	R-HSA-72306	5.833089e-01	0.234
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	5.839371e-01	0.234
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.848169e-01	0.233
RNA Polymerase III Transcription Termination	R-HSA-73980	5.848169e-01	0.233
FOXO-mediated transcription of cell death genes	R-HSA-9614657	5.848169e-01	0.233
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.848169e-01	0.233
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.848169e-01	0.233
Apoptotic factor-mediated response	R-HSA-111471	5.848169e-01	0.233
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.848169e-01	0.233
Transport of connexons to the plasma membrane	R-HSA-190872	5.848169e-01	0.233
Tie2 Signaling	R-HSA-210993	5.848169e-01	0.233
G alpha (s) signalling events	R-HSA-418555	5.888226e-01	0.230
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.896694e-01	0.229
Proteasome assembly	R-HSA-9907900	5.906167e-01	0.229
Gap junction trafficking	R-HSA-190828	5.906167e-01	0.229
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.906167e-01	0.229
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.003968e-01	0.222
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.003968e-01	0.222
Pyrimidine biosynthesis	R-HSA-500753	6.003968e-01	0.222
Specification of the neural plate border	R-HSA-9834899	6.003968e-01	0.222
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	6.003968e-01	0.222
The NLRP3 inflammasome	R-HSA-844456	6.003968e-01	0.222
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.003968e-01	0.222
Rap1 signalling	R-HSA-392517	6.003968e-01	0.222
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.003968e-01	0.222
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.003968e-01	0.222
Other interleukin signaling	R-HSA-449836	6.003968e-01	0.222
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.009447e-01	0.221
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	6.009447e-01	0.221
Fanconi Anemia Pathway	R-HSA-6783310	6.009447e-01	0.221
Asymmetric localization of PCP proteins	R-HSA-4608870	6.009447e-01	0.221
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.009447e-01	0.221
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.009447e-01	0.221
DAG and IP3 signaling	R-HSA-1489509	6.009447e-01	0.221
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.037231e-01	0.219
FOXO-mediated transcription	R-HSA-9614085	6.055589e-01	0.218
HATs acetylate histones	R-HSA-3214847	6.055589e-01	0.218
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.110750e-01	0.214
Signaling by TGFBR3	R-HSA-9839373	6.110750e-01	0.214
Gastrulation	R-HSA-9758941	6.140520e-01	0.212
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.144183e-01	0.212
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.153929e-01	0.211
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.153929e-01	0.211
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.153929e-01	0.211
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.153929e-01	0.211
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.153929e-01	0.211
VxPx cargo-targeting to cilium	R-HSA-5620916	6.153929e-01	0.211
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.153929e-01	0.211
Signaling by NODAL	R-HSA-1181150	6.153929e-01	0.211
Keratan sulfate degradation	R-HSA-2022857	6.153929e-01	0.211
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.153929e-01	0.211
Wax and plasmalogen biosynthesis	R-HSA-8848584	6.153929e-01	0.211
Protein hydroxylation	R-HSA-9629569	6.153929e-01	0.211
Signal transduction by L1	R-HSA-445144	6.153929e-01	0.211
Eicosanoid ligand-binding receptors	R-HSA-391903	6.153929e-01	0.211
Interleukin-1 signaling	R-HSA-9020702	6.195875e-01	0.208
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.210080e-01	0.207
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.210080e-01	0.207
rRNA processing	R-HSA-72312	6.248799e-01	0.204
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.298271e-01	0.201
Early Phase of HIV Life Cycle	R-HSA-162594	6.298271e-01	0.201
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.298271e-01	0.201
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.298271e-01	0.201
Lagging Strand Synthesis	R-HSA-69186	6.298271e-01	0.201
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.298271e-01	0.201
Basigin interactions	R-HSA-210991	6.298271e-01	0.201
NGF-stimulated transcription	R-HSA-9031628	6.307441e-01	0.200
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.307441e-01	0.200
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.310337e-01	0.200
Interleukin-1 family signaling	R-HSA-446652	6.310337e-01	0.200
G alpha (12/13) signalling events	R-HSA-416482	6.381423e-01	0.195
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.400347e-01	0.194
Opioid Signalling	R-HSA-111885	6.400347e-01	0.194
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.402842e-01	0.194
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.402842e-01	0.194
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	6.421097e-01	0.192
Death Receptor Signaling	R-HSA-73887	6.421097e-01	0.192
CS-GAG biosynthesis	R-HSA-2022870	6.437205e-01	0.191
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.437205e-01	0.191
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.437205e-01	0.191
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.437205e-01	0.191
Ribavirin ADME	R-HSA-9755088	6.437205e-01	0.191
Assembly Of The HIV Virion	R-HSA-175474	6.437205e-01	0.191
Activation of HOX genes during differentiation	R-HSA-5619507	6.466888e-01	0.189
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.466888e-01	0.189
Regulation of RAS by GAPs	R-HSA-5658442	6.496293e-01	0.187
PI3K Cascade	R-HSA-109704	6.496293e-01	0.187
Signaling by FGFR2 in disease	R-HSA-5655253	6.496293e-01	0.187
Membrane Trafficking	R-HSA-199991	6.510939e-01	0.186
Reproduction	R-HSA-1474165	6.552931e-01	0.184
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.570933e-01	0.182
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.570933e-01	0.182
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.570933e-01	0.182
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.570933e-01	0.182
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.570933e-01	0.182
Meiotic recombination	R-HSA-912446	6.587804e-01	0.181
Muscle contraction	R-HSA-397014	6.611404e-01	0.180
Circadian clock	R-HSA-9909396	6.668638e-01	0.176
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.677392e-01	0.175
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.677392e-01	0.175
Uptake and actions of bacterial toxins	R-HSA-5339562	6.677392e-01	0.175
Interleukin receptor SHC signaling	R-HSA-912526	6.699648e-01	0.174
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.699648e-01	0.174
Biosynthesis of maresins	R-HSA-9018682	6.699648e-01	0.174
Formation of the ureteric bud	R-HSA-9830674	6.699648e-01	0.174
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.724841e-01	0.172
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.724841e-01	0.172
Stimuli-sensing channels	R-HSA-2672351	6.724841e-01	0.172
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.765069e-01	0.170
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.765069e-01	0.170
Smooth Muscle Contraction	R-HSA-445355	6.765069e-01	0.170
Nucleotide biosynthesis	R-HSA-8956320	6.765069e-01	0.170
CYP2E1 reactions	R-HSA-211999	6.823540e-01	0.166
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	6.823540e-01	0.166
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.823540e-01	0.166
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.823540e-01	0.166
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.823540e-01	0.166
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	6.823540e-01	0.166
Plasma lipoprotein assembly	R-HSA-8963898	6.823540e-01	0.166
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.824639e-01	0.166
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.850855e-01	0.164
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.850855e-01	0.164
Cilium Assembly	R-HSA-5617833	6.860181e-01	0.164
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.934767e-01	0.159
Paracetamol ADME	R-HSA-9753281	6.934767e-01	0.159
G alpha (z) signalling events	R-HSA-418597	6.934767e-01	0.159
G protein gated Potassium channels	R-HSA-1296059	6.942789e-01	0.158
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	6.942789e-01	0.158
Activation of G protein gated Potassium channels	R-HSA-1296041	6.942789e-01	0.158
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.942789e-01	0.158
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.942789e-01	0.158
Acyl chain remodelling of PS	R-HSA-1482801	6.942789e-01	0.158
HDMs demethylate histones	R-HSA-3214842	6.942789e-01	0.158
MicroRNA (miRNA) biogenesis	R-HSA-203927	6.942789e-01	0.158
TGFBR3 expression	R-HSA-9839394	6.942789e-01	0.158
Retinoid cycle disease events	R-HSA-2453864	6.942789e-01	0.158
Diseases associated with visual transduction	R-HSA-2474795	6.942789e-01	0.158
Diseases of the neuronal system	R-HSA-9675143	6.942789e-01	0.158
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.016825e-01	0.154
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.016825e-01	0.154
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.016825e-01	0.154
HCMV Infection	R-HSA-9609646	7.032291e-01	0.153
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.057567e-01	0.151
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.057567e-01	0.151
Sphingolipid catabolism	R-HSA-9845614	7.057567e-01	0.151
Metalloprotease DUBs	R-HSA-5689901	7.057567e-01	0.151
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.057567e-01	0.151
TRP channels	R-HSA-3295583	7.057567e-01	0.151
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.057567e-01	0.151
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.057567e-01	0.151
IRS-mediated signalling	R-HSA-112399	7.097050e-01	0.149
Synthesis of PA	R-HSA-1483166	7.097050e-01	0.149
Peptide chain elongation	R-HSA-156902	7.162121e-01	0.145
Interaction between L1 and Ankyrins	R-HSA-445095	7.168044e-01	0.145
Packaging Of Telomere Ends	R-HSA-171306	7.168044e-01	0.145
RNA Polymerase I Promoter Opening	R-HSA-73728	7.168044e-01	0.145
Cristae formation	R-HSA-8949613	7.168044e-01	0.145
Signaling by BMP	R-HSA-201451	7.168044e-01	0.145
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.168044e-01	0.145
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.168044e-01	0.145
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.175463e-01	0.144
Dual incision in TC-NER	R-HSA-6782135	7.175463e-01	0.144
Peroxisomal protein import	R-HSA-9033241	7.252088e-01	0.140
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.252088e-01	0.140
Role of phospholipids in phagocytosis	R-HSA-2029485	7.256561e-01	0.139
Telomere Extension By Telomerase	R-HSA-171319	7.274378e-01	0.138
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.274378e-01	0.138
Base Excision Repair	R-HSA-73884	7.289109e-01	0.137
Cap-dependent Translation Initiation	R-HSA-72737	7.311476e-01	0.136
Eukaryotic Translation Initiation	R-HSA-72613	7.311476e-01	0.136
Kinesins	R-HSA-983189	7.326949e-01	0.135
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.350912e-01	0.134
Late endosomal microautophagy	R-HSA-9615710	7.376727e-01	0.132
Termination of translesion DNA synthesis	R-HSA-5656169	7.376727e-01	0.132
Regulation of gene expression in beta cells	R-HSA-210745	7.376727e-01	0.132
IRS-related events triggered by IGF1R	R-HSA-2428928	7.400069e-01	0.131
Aquaporin-mediated transport	R-HSA-445717	7.400069e-01	0.131
PLC beta mediated events	R-HSA-112043	7.400069e-01	0.131
Eukaryotic Translation Elongation	R-HSA-156842	7.471174e-01	0.127
Signaling by Insulin receptor	R-HSA-74752	7.471174e-01	0.127
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.471174e-01	0.127
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.471473e-01	0.127
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.471473e-01	0.127
Signaling by PDGF	R-HSA-186797	7.471473e-01	0.127
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.475238e-01	0.126
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.475238e-01	0.126
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.475238e-01	0.126
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.475238e-01	0.126
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.475238e-01	0.126
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.500735e-01	0.125
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	7.501243e-01	0.125
SARS-CoV-2 Infection	R-HSA-9694516	7.506688e-01	0.125
Assembly of the pre-replicative complex	R-HSA-68867	7.529651e-01	0.123
G1/S DNA Damage Checkpoints	R-HSA-69615	7.541189e-01	0.123
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.570055e-01	0.121
Molecules associated with elastic fibres	R-HSA-2129379	7.570055e-01	0.121
Phospholipid metabolism	R-HSA-1483257	7.628458e-01	0.118
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.643341e-01	0.117
G0 and Early G1	R-HSA-1538133	7.661318e-01	0.116
Inwardly rectifying K+ channels	R-HSA-1296065	7.661318e-01	0.116
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.661318e-01	0.116
DNA strand elongation	R-HSA-69190	7.661318e-01	0.116
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.661318e-01	0.116
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.697288e-01	0.114
Signaling by WNT	R-HSA-195721	7.726813e-01	0.112
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	7.740460e-01	0.111
tRNA modification in the nucleus and cytosol	R-HSA-6782315	7.740460e-01	0.111
Keratan sulfate biosynthesis	R-HSA-2022854	7.749158e-01	0.111
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.749158e-01	0.111
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.749158e-01	0.111
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.749158e-01	0.111
Regulation of necroptotic cell death	R-HSA-5675482	7.749158e-01	0.111
Regulation of MECP2 expression and activity	R-HSA-9022692	7.749158e-01	0.111
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.752747e-01	0.111
Potassium Channels	R-HSA-1296071	7.752747e-01	0.111
G-protein mediated events	R-HSA-112040	7.803681e-01	0.108
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.815743e-01	0.107
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.815743e-01	0.107
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.815743e-01	0.107
TCF dependent signaling in response to WNT	R-HSA-201681	7.829517e-01	0.106
Resolution of D-Loop Structures	R-HSA-5693537	7.833704e-01	0.106
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.833704e-01	0.106
CS/DS degradation	R-HSA-2024101	7.833704e-01	0.106
Acyl chain remodelling of PC	R-HSA-1482788	7.833704e-01	0.106
Vpu mediated degradation of CD4	R-HSA-180534	7.833704e-01	0.106
Miscellaneous transport and binding events	R-HSA-5223345	7.833704e-01	0.106
Heme degradation	R-HSA-189483	7.833704e-01	0.106
O-linked glycosylation of mucins	R-HSA-913709	7.865347e-01	0.104
Transcription of the HIV genome	R-HSA-167172	7.865347e-01	0.104
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.865347e-01	0.104
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	7.915079e-01	0.102
Dual Incision in GG-NER	R-HSA-5696400	7.915079e-01	0.102
eNOS activation	R-HSA-203615	7.915079e-01	0.102
NOD1/2 Signaling Pathway	R-HSA-168638	7.915079e-01	0.102
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.915079e-01	0.102
Gap junction assembly	R-HSA-190861	7.915079e-01	0.102
Signaling by NOTCH2	R-HSA-1980145	7.915079e-01	0.102
Signal amplification	R-HSA-392518	7.915079e-01	0.102
Mitophagy	R-HSA-5205647	7.915079e-01	0.102
Viral Infection Pathways	R-HSA-9824446	7.970200e-01	0.099
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.984124e-01	0.098
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.984124e-01	0.098
Cyclin E associated events during G1/S transition	R-HSA-69202	7.984124e-01	0.098
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.993402e-01	0.097
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.993402e-01	0.097
Acyl chain remodelling of PE	R-HSA-1482839	7.993402e-01	0.097
PERK regulates gene expression	R-HSA-381042	7.993402e-01	0.097
Regulation of mitotic cell cycle	R-HSA-453276	8.041290e-01	0.095
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.041290e-01	0.095
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.041290e-01	0.095
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	8.041290e-01	0.095
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.068788e-01	0.093
PRC2 methylates histones and DNA	R-HSA-212300	8.068788e-01	0.093
RNA Polymerase III Transcription	R-HSA-74158	8.068788e-01	0.093
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.068788e-01	0.093
G1/S-Specific Transcription	R-HSA-69205	8.068788e-01	0.093
HS-GAG biosynthesis	R-HSA-2022928	8.068788e-01	0.093
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.097011e-01	0.092
Adipogenesis	R-HSA-9843745	8.121937e-01	0.090
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.141345e-01	0.089
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.141345e-01	0.089
Degradation of DVL	R-HSA-4641258	8.141345e-01	0.089
Degradation of AXIN	R-HSA-4641257	8.141345e-01	0.089
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.141345e-01	0.089
Cleavage of the damaged purine	R-HSA-110331	8.141345e-01	0.089
SLC-mediated transport of organic cations	R-HSA-549127	8.141345e-01	0.089
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.141345e-01	0.089
Collagen chain trimerization	R-HSA-8948216	8.141345e-01	0.089
Metabolism of folate and pterines	R-HSA-196757	8.141345e-01	0.089
Switching of origins to a post-replicative state	R-HSA-69052	8.151315e-01	0.089
Ca2+ pathway	R-HSA-4086398	8.151315e-01	0.089
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.151315e-01	0.089
Aspirin ADME	R-HSA-9749641	8.151315e-01	0.089
Signaling by NOTCH4	R-HSA-9013694	8.204230e-01	0.086
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.211181e-01	0.086
Depurination	R-HSA-73927	8.211181e-01	0.086
Elastic fibre formation	R-HSA-1566948	8.211181e-01	0.086
Purine salvage	R-HSA-74217	8.211181e-01	0.086
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.211181e-01	0.086
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.211181e-01	0.086
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.255783e-01	0.083
Protein ubiquitination	R-HSA-8852135	8.255783e-01	0.083
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.255783e-01	0.083
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.278398e-01	0.082
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.278398e-01	0.082
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.278398e-01	0.082
RAS processing	R-HSA-9648002	8.278398e-01	0.082
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.278398e-01	0.082
UCH proteinases	R-HSA-5689603	8.306003e-01	0.081
Synthesis of DNA	R-HSA-69239	8.324332e-01	0.080
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.343092e-01	0.079
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.343092e-01	0.079
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.343092e-01	0.079
Translation of Structural Proteins	R-HSA-9694635	8.354916e-01	0.078
Integration of energy metabolism	R-HSA-163685	8.355641e-01	0.078
Antigen processing-Cross presentation	R-HSA-1236975	8.365801e-01	0.077
ABC transporter disorders	R-HSA-5619084	8.402549e-01	0.076
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.405359e-01	0.075
Hh mutants are degraded by ERAD	R-HSA-5362768	8.405359e-01	0.075
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.405359e-01	0.075
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.405359e-01	0.075
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.405359e-01	0.075
DNA Replication Pre-Initiation	R-HSA-69002	8.406384e-01	0.075
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.417065e-01	0.075
Developmental Cell Lineages	R-HSA-9734767	8.463166e-01	0.072
Degradation of CRY and PER proteins	R-HSA-9932298	8.465290e-01	0.072
Scavenging by Class A Receptors	R-HSA-3000480	8.465290e-01	0.072
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.465290e-01	0.072
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.465290e-01	0.072
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.522972e-01	0.069
Cytosolic tRNA aminoacylation	R-HSA-379716	8.522972e-01	0.069
Macroautophagy	R-HSA-1632852	8.531385e-01	0.069
Amyloid fiber formation	R-HSA-977225	8.538043e-01	0.069
Defective pyroptosis	R-HSA-9710421	8.578489e-01	0.067
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.578489e-01	0.067
Response of Mtb to phagocytosis	R-HSA-9637690	8.578489e-01	0.067
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	8.580827e-01	0.066
Keratinization	R-HSA-6805567	8.618404e-01	0.065
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.622464e-01	0.064
Cytoprotection by HMOX1	R-HSA-9707564	8.622464e-01	0.064
SARS-CoV-1 Infection	R-HSA-9678108	8.627414e-01	0.064
Surfactant metabolism	R-HSA-5683826	8.631923e-01	0.064
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.631923e-01	0.064
Amine ligand-binding receptors	R-HSA-375280	8.631923e-01	0.064
FCERI mediated NF-kB activation	R-HSA-2871837	8.660275e-01	0.062
Signaling by NOTCH	R-HSA-157118	8.674385e-01	0.062
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.683351e-01	0.061
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.683351e-01	0.061
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	8.683351e-01	0.061
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.683351e-01	0.061
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.683351e-01	0.061
FCERI mediated Ca+2 mobilization	R-HSA-2871809	8.700725e-01	0.060
Vesicle-mediated transport	R-HSA-5653656	8.714770e-01	0.060
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.732849e-01	0.059
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.732849e-01	0.059
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.732849e-01	0.059
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.732849e-01	0.059
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.732849e-01	0.059
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.778053e-01	0.057
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.780490e-01	0.056
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	8.780490e-01	0.056
Chaperonin-mediated protein folding	R-HSA-390466	8.814335e-01	0.055
Intraflagellar transport	R-HSA-5620924	8.826342e-01	0.054
Gluconeogenesis	R-HSA-70263	8.826342e-01	0.054
Metal ion SLC transporters	R-HSA-425410	8.826342e-01	0.054
Keratan sulfate/keratin metabolism	R-HSA-1638074	8.870472e-01	0.052
ER-Phagosome pathway	R-HSA-1236974	8.883931e-01	0.051
Azathioprine ADME	R-HSA-9748787	8.912946e-01	0.050
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	8.912946e-01	0.050
Protein localization	R-HSA-9609507	8.915219e-01	0.050
DNA Replication	R-HSA-69306	8.915219e-01	0.050
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.949723e-01	0.048
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.953825e-01	0.048
Hedgehog ligand biogenesis	R-HSA-5358346	8.953825e-01	0.048
Branched-chain amino acid catabolism	R-HSA-70895	8.953825e-01	0.048
The phototransduction cascade	R-HSA-2514856	8.953825e-01	0.048
PPARA activates gene expression	R-HSA-1989781	8.965751e-01	0.047
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.981251e-01	0.047
Ion channel transport	R-HSA-983712	8.986116e-01	0.046
Autophagy	R-HSA-9612973	8.990233e-01	0.046
Orc1 removal from chromatin	R-HSA-68949	8.993170e-01	0.046
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.993170e-01	0.046
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.993170e-01	0.046
Protein folding	R-HSA-391251	9.011895e-01	0.045
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.011895e-01	0.045
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.014203e-01	0.045
Cellular response to starvation	R-HSA-9711097	9.037670e-01	0.044
Infectious disease	R-HSA-5663205	9.042218e-01	0.044
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.067482e-01	0.043
Collagen formation	R-HSA-1474290	9.070622e-01	0.042
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.098746e-01	0.041
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.102558e-01	0.041
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.102558e-01	0.041
Signaling by NOTCH3	R-HSA-9012852	9.102558e-01	0.041
Formation of a pool of free 40S subunits	R-HSA-72689	9.126073e-01	0.040
Eukaryotic Translation Termination	R-HSA-72764	9.126073e-01	0.040
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.136187e-01	0.039
Ion homeostasis	R-HSA-5578775	9.136318e-01	0.039
TNF signaling	R-HSA-75893	9.136318e-01	0.039
COPI-mediated anterograde transport	R-HSA-6807878	9.152621e-01	0.038
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.152621e-01	0.038
Cardiac conduction	R-HSA-5576891	9.193782e-01	0.037
Extracellular matrix organization	R-HSA-1474244	9.196855e-01	0.036
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.200080e-01	0.036
Degradation of the extracellular matrix	R-HSA-1474228	9.215388e-01	0.035
Regulation of beta-cell development	R-HSA-186712	9.230176e-01	0.035
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.230176e-01	0.035
ABC-family proteins mediated transport	R-HSA-382556	9.251424e-01	0.034
RAB geranylgeranylation	R-HSA-8873719	9.259141e-01	0.033
Metabolism of polyamines	R-HSA-351202	9.259141e-01	0.033
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.259141e-01	0.033
tRNA Aminoacylation	R-HSA-379724	9.259141e-01	0.033
Selenocysteine synthesis	R-HSA-2408557	9.274371e-01	0.033
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.287019e-01	0.032
Nucleotide salvage	R-HSA-8956321	9.287019e-01	0.032
Collagen degradation	R-HSA-1442490	9.287019e-01	0.032
Mitochondrial protein import	R-HSA-1268020	9.313849e-01	0.031
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.313849e-01	0.031
Viral mRNA Translation	R-HSA-192823	9.318289e-01	0.031
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.334271e-01	0.030
RSV-host interactions	R-HSA-9833110	9.359685e-01	0.029
Xenobiotics	R-HSA-211981	9.364523e-01	0.029
CD22 mediated BCR regulation	R-HSA-5690714	9.364523e-01	0.029
Ion transport by P-type ATPases	R-HSA-936837	9.364523e-01	0.029
Nucleotide Excision Repair	R-HSA-5696398	9.379479e-01	0.028
Cellular response to hypoxia	R-HSA-1234174	9.388441e-01	0.027
Platelet homeostasis	R-HSA-418346	9.398692e-01	0.027
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.417340e-01	0.026
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.454935e-01	0.024
COPII-mediated vesicle transport	R-HSA-204005	9.495204e-01	0.022
Diseases of glycosylation	R-HSA-3781865	9.509737e-01	0.022
ER to Golgi Anterograde Transport	R-HSA-199977	9.510143e-01	0.022
Metabolism of cofactors	R-HSA-8978934	9.514210e-01	0.022
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.514210e-01	0.022
Metabolism of porphyrins	R-HSA-189445	9.514210e-01	0.022
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.518183e-01	0.021
Purine catabolism	R-HSA-74259	9.532502e-01	0.021
Translation	R-HSA-72766	9.571326e-01	0.019
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.614148e-01	0.017
Nuclear Receptor transcription pathway	R-HSA-383280	9.628683e-01	0.016
Integrin cell surface interactions	R-HSA-216083	9.628683e-01	0.016
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.669087e-01	0.015
Co-inhibition by PD-1	R-HSA-389948	9.677571e-01	0.014
G1/S Transition	R-HSA-69206	9.702490e-01	0.013
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.705101e-01	0.013
Peroxisomal lipid metabolism	R-HSA-390918	9.705101e-01	0.013
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.726908e-01	0.012
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.726908e-01	0.012
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.738756e-01	0.011
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.756638e-01	0.011
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.768615e-01	0.010
Golgi-to-ER retrograde transport	R-HSA-8856688	9.770784e-01	0.010
Neurotransmitter release cycle	R-HSA-112310	9.774640e-01	0.010
Class B/2 (Secretin family receptors)	R-HSA-373080	9.774640e-01	0.010
SLC-mediated transmembrane transport	R-HSA-425407	9.788302e-01	0.009
Drug ADME	R-HSA-9748784	9.807101e-01	0.008
O-linked glycosylation	R-HSA-5173105	9.811786e-01	0.008
Mitochondrial protein degradation	R-HSA-9837999	9.814041e-01	0.008
G alpha (i) signalling events	R-HSA-418594	9.829246e-01	0.007
Mitochondrial translation elongation	R-HSA-5389840	9.834297e-01	0.007
Mitochondrial translation initiation	R-HSA-5368286	9.846562e-01	0.007
Regulation of insulin secretion	R-HSA-422356	9.846562e-01	0.007
Peptide ligand-binding receptors	R-HSA-375276	9.847414e-01	0.007
Synthesis of bile acids and bile salts	R-HSA-192105	9.852350e-01	0.006
Visual phototransduction	R-HSA-2187338	9.869261e-01	0.006
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.873403e-01	0.006
Glycosaminoglycan metabolism	R-HSA-1630316	9.876447e-01	0.005
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.881704e-01	0.005
Mitochondrial translation termination	R-HSA-5419276	9.903291e-01	0.004
Transport to the Golgi and subsequent modification	R-HSA-948021	9.906056e-01	0.004
Bile acid and bile salt metabolism	R-HSA-194068	9.906942e-01	0.004
Glycerophospholipid biosynthesis	R-HSA-1483206	9.908888e-01	0.004
Post-translational protein modification	R-HSA-597592	9.922193e-01	0.003
Selenoamino acid metabolism	R-HSA-2408522	9.926071e-01	0.003
Rab regulation of trafficking	R-HSA-9007101	9.934190e-01	0.003
Peptide hormone metabolism	R-HSA-2980736	9.934190e-01	0.003
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.943585e-01	0.002
Neddylation	R-HSA-8951664	9.949385e-01	0.002
Nucleotide catabolism	R-HSA-8956319	9.960115e-01	0.002
Metabolism of nucleotides	R-HSA-15869	9.968420e-01	0.001
GPCR downstream signalling	R-HSA-388396	9.973162e-01	0.001
Mitochondrial translation	R-HSA-5368287	9.973899e-01	0.001
Transport of small molecules	R-HSA-382551	9.975444e-01	0.001
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.979292e-01	0.001
Sphingolipid metabolism	R-HSA-428157	9.979844e-01	0.001
Signaling by GPCR	R-HSA-372790	9.979899e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.984452e-01	0.001
Arachidonate metabolism	R-HSA-2142753	9.985367e-01	0.001
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.986082e-01	0.001
Interferon gamma signaling	R-HSA-877300	9.988833e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.991801e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.991825e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.994505e-01	0.000
Respiratory electron transport	R-HSA-611105	9.994844e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.997871e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999338e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999372e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999782e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999940e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999943e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999983e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999989e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999991e-01	0.000
Biological oxidations	R-HSA-211859	9.999998e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cellular response to heat stress	R-HSA-3371556	3.330669e-16	15.477
HSF1-dependent transactivation	R-HSA-3371571	4.041212e-14	13.393
Attenuation phase	R-HSA-3371568	3.532952e-12	11.452
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.675060e-12	11.435
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.651290e-11	10.438
Eukaryotic Translation Elongation	R-HSA-156842	6.532297e-11	10.185
HSF1 activation	R-HSA-3371511	6.717504e-11	10.173
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.717654e-09	8.765
Cap-dependent Translation Initiation	R-HSA-72737	1.873353e-09	8.727
Eukaryotic Translation Initiation	R-HSA-72613	1.873353e-09	8.727
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.066868e-09	8.217
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.803288e-09	8.108
Nervous system development	R-HSA-9675108	9.124453e-09	8.040
Axon guidance	R-HSA-422475	1.259711e-08	7.900
Translation initiation complex formation	R-HSA-72649	1.474695e-08	7.831
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.592585e-08	7.798
Peptide chain elongation	R-HSA-156902	1.784609e-08	7.748
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.943069e-08	7.712
Ribosomal scanning and start codon recognition	R-HSA-72702	2.318644e-08	7.635
Regulation of CDH1 Function	R-HSA-9764561	2.889153e-08	7.539
Cell-Cell communication	R-HSA-1500931	2.837710e-08	7.547
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.498389e-08	7.456
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.635914e-08	7.178
Cell junction organization	R-HSA-446728	7.941188e-08	7.100
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.895985e-08	7.005
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.390470e-07	6.857
Influenza Infection	R-HSA-168255	1.779307e-07	6.750
Ribosome-associated quality control	R-HSA-9948299	2.209453e-07	6.656
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.453032e-07	6.610
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.453032e-07	6.610
Interferon Signaling	R-HSA-913531	2.315939e-07	6.635
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.238026e-07	6.281
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.896063e-07	6.229
UCH proteinases	R-HSA-5689603	9.880347e-07	6.005
Formation of a pool of free 40S subunits	R-HSA-72689	1.372871e-06	5.862
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.333279e-06	5.875
Eukaryotic Translation Termination	R-HSA-72764	1.372871e-06	5.862
Metabolism of RNA	R-HSA-8953854	1.521300e-06	5.818
Signaling by ROBO receptors	R-HSA-376176	1.704549e-06	5.768
PKR-mediated signaling	R-HSA-9833482	1.831155e-06	5.737
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.914203e-06	5.718
Cellular response to starvation	R-HSA-9711097	2.102597e-06	5.677
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.138569e-06	5.670
Cytokine Signaling in Immune system	R-HSA-1280215	2.447199e-06	5.611
Selenocysteine synthesis	R-HSA-2408557	3.008129e-06	5.522
Recycling pathway of L1	R-HSA-437239	3.575084e-06	5.447
Viral mRNA Translation	R-HSA-192823	3.859016e-06	5.414
ISG15 antiviral mechanism	R-HSA-1169408	3.746864e-06	5.426
Aggrephagy	R-HSA-9646399	3.906610e-06	5.408
Cell-cell junction organization	R-HSA-421270	4.033457e-06	5.394
SARS-CoV-1-host interactions	R-HSA-9692914	6.242108e-06	5.205
M Phase	R-HSA-68886	6.990968e-06	5.155
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.054763e-06	5.152
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.525406e-05	4.817
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.529477e-05	4.815
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.573726e-05	4.803
Adherens junctions interactions	R-HSA-418990	1.695424e-05	4.771
Interleukin-12 signaling	R-HSA-9020591	1.800669e-05	4.745
Chaperone Mediated Autophagy	R-HSA-9613829	1.867985e-05	4.729
Cell Cycle	R-HSA-1640170	1.984855e-05	4.702
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.131805e-05	4.671
L1CAM interactions	R-HSA-373760	2.331302e-05	4.632
Selective autophagy	R-HSA-9663891	2.475988e-05	4.606
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.615873e-05	4.582
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.615873e-05	4.582
Signaling by RAF1 mutants	R-HSA-9656223	3.138215e-05	4.503
Separation of Sister Chromatids	R-HSA-2467813	3.244447e-05	4.489
Selenoamino acid metabolism	R-HSA-2408522	3.244447e-05	4.489
SARS-CoV-2-host interactions	R-HSA-9705683	3.457963e-05	4.461
rRNA processing	R-HSA-72312	4.539856e-05	4.343
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.327557e-05	4.273
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.726305e-05	4.242
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.717294e-05	4.173
Signaling downstream of RAS mutants	R-HSA-9649948	7.397193e-05	4.131
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.397193e-05	4.131
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.397193e-05	4.131
Signaling by RAS mutants	R-HSA-6802949	7.397193e-05	4.131
Apoptotic execution phase	R-HSA-75153	7.397193e-05	4.131
Translation	R-HSA-72766	8.063583e-05	4.093
Interleukin-12 family signaling	R-HSA-447115	7.961471e-05	4.099
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.077274e-05	4.093
Signaling by ALK in cancer	R-HSA-9700206	8.077274e-05	4.093
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.317783e-05	4.031
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.752099e-05	4.011
Signaling by Hippo	R-HSA-2028269	1.069241e-04	3.971
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.172821e-04	3.931
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.183117e-04	3.927
Regulation of PTEN localization	R-HSA-8948747	1.345971e-04	3.871
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.804220e-04	3.744
Metalloprotease DUBs	R-HSA-5689901	1.810337e-04	3.742
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.910591e-04	3.719
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.085063e-04	3.681
SARS-CoV-1 Infection	R-HSA-9678108	2.170441e-04	3.663
Cell Cycle, Mitotic	R-HSA-69278	2.545666e-04	3.594
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.414527e-04	3.617
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.549222e-04	3.594
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.708522e-04	3.567
Chaperonin-mediated protein folding	R-HSA-390466	2.718147e-04	3.566
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.783341e-04	3.555
Cellular Senescence	R-HSA-2559583	3.055652e-04	3.515
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.145158e-04	3.502
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.173586e-04	3.498
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.173586e-04	3.498
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.439067e-04	3.464
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.661628e-04	3.436
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.661628e-04	3.436
Hedgehog 'off' state	R-HSA-5610787	3.691702e-04	3.433
Autophagy	R-HSA-9612973	3.482130e-04	3.458
Glycolysis	R-HSA-70171	3.691702e-04	3.433
FLT3 signaling by CBL mutants	R-HSA-9706377	3.885787e-04	3.411
Downregulation of ERBB2 signaling	R-HSA-8863795	3.941908e-04	3.404
Host Interactions of HIV factors	R-HSA-162909	4.414111e-04	3.355
Josephin domain DUBs	R-HSA-5689877	4.448083e-04	3.352
mTORC1-mediated signalling	R-HSA-166208	4.536028e-04	3.343
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.536028e-04	3.343
Protein folding	R-HSA-391251	4.916607e-04	3.308
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.710963e-04	3.327
Degradation of CDH1	R-HSA-9766229	4.967263e-04	3.304
Gap junction trafficking and regulation	R-HSA-157858	4.967263e-04	3.304
Mitotic Anaphase	R-HSA-68882	5.406800e-04	3.267
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.597388e-04	3.252
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.689212e-04	3.245
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.728940e-04	3.242
PTEN Regulation	R-HSA-6807070	6.443110e-04	3.191
Chromatin modifying enzymes	R-HSA-3247509	6.633480e-04	3.178
Maturation of protein E	R-HSA-9683683	6.385888e-04	3.195
Maturation of protein E	R-HSA-9694493	6.385888e-04	3.195
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.781751e-04	3.169
Chromatin organization	R-HSA-4839726	6.785757e-04	3.168
MAP2K and MAPK activation	R-HSA-5674135	6.798024e-04	3.168
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.798024e-04	3.168
Viral Infection Pathways	R-HSA-9824446	7.052732e-04	3.152
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.104086e-04	3.148
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	7.357725e-04	3.133
Macroautophagy	R-HSA-1632852	7.433995e-04	3.129
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.419655e-04	3.075
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	8.088552e-04	3.092
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.419655e-04	3.075
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.890620e-04	3.005
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.890620e-04	3.005
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.890620e-04	3.005
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.890620e-04	3.005
Deubiquitination	R-HSA-5688426	9.265571e-04	3.033
Clathrin-mediated endocytosis	R-HSA-8856828	9.164349e-04	3.038
Transport of connexons to the plasma membrane	R-HSA-190872	9.233583e-04	3.035
Gap junction trafficking	R-HSA-190828	1.025299e-03	2.989
Oncogene Induced Senescence	R-HSA-2559585	1.058543e-03	2.975
G2/M Transition	R-HSA-69275	1.069268e-03	2.971
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.118562e-03	2.951
VLDLR internalisation and degradation	R-HSA-8866427	1.118562e-03	2.951
p75NTR recruits signalling complexes	R-HSA-209543	1.118562e-03	2.951
Ub-specific processing proteases	R-HSA-5689880	1.143560e-03	2.942
Mitotic G2-G2/M phases	R-HSA-453274	1.202247e-03	2.920
Negative regulation of MET activity	R-HSA-6807004	1.406971e-03	2.852
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.406971e-03	2.852
Developmental Biology	R-HSA-1266738	1.409334e-03	2.851
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.415481e-03	2.849
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.711320e-03	2.767
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.711320e-03	2.767
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.711320e-03	2.767
Mitotic Prometaphase	R-HSA-68877	1.598185e-03	2.796
Signaling by Hedgehog	R-HSA-5358351	1.531591e-03	2.815
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.629928e-03	2.788
Cellular response to chemical stress	R-HSA-9711123	1.746179e-03	2.758
Regulation of PTEN gene transcription	R-HSA-8943724	1.835102e-03	2.736
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.835680e-03	2.736
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.835680e-03	2.736
MET interacts with TNS proteins	R-HSA-8875513	1.865108e-03	2.729
Glucose metabolism	R-HSA-70326	1.885281e-03	2.725
Oncogenic MAPK signaling	R-HSA-6802957	2.003925e-03	2.698
SARS-CoV-2 Infection	R-HSA-9694516	2.018090e-03	2.695
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.041350e-03	2.690
Downregulation of ERBB4 signaling	R-HSA-1253288	2.041350e-03	2.690
Modulation by Mtb of host immune system	R-HSA-9637628	2.041350e-03	2.690
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.041350e-03	2.690
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.352991e-03	2.628
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.352991e-03	2.628
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.221118e-03	2.653
Regulation of RAS by GAPs	R-HSA-5658442	2.139690e-03	2.670
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.412645e-03	2.618
Hh mutants are degraded by ERAD	R-HSA-5362768	2.412645e-03	2.618
Signaling by NOTCH4	R-HSA-9013694	2.259079e-03	2.646
p75NTR signals via NF-kB	R-HSA-193639	2.352991e-03	2.628
Cell-extracellular matrix interactions	R-HSA-446353	2.352991e-03	2.628
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.475758e-03	2.606
Semaphorin interactions	R-HSA-373755	2.495311e-03	2.603
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.496575e-03	2.603
Degradation of GLI2 by the proteasome	R-HSA-5610783	2.732013e-03	2.564
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.674050e-03	2.573
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.674050e-03	2.573
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.978156e-03	2.526
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.978156e-03	2.526
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.865484e-03	2.543
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.732013e-03	2.564
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.785831e-03	2.555
HATs acetylate histones	R-HSA-3214847	2.819896e-03	2.550
Post NMDA receptor activation events	R-HSA-438064	2.585911e-03	2.587
Signal Transduction	R-HSA-162582	2.818949e-03	2.550
Regulation of NF-kappa B signaling	R-HSA-9758274	2.926233e-03	2.534
Negative regulation of FLT3	R-HSA-9706369	2.926233e-03	2.534
Apoptosis	R-HSA-109581	3.015066e-03	2.521
MTOR signalling	R-HSA-165159	3.083451e-03	2.511
Nuclear Receptor transcription pathway	R-HSA-383280	3.228431e-03	2.491
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.399101e-03	2.469
Vpu mediated degradation of CD4	R-HSA-180534	3.399101e-03	2.469
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.399101e-03	2.469
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.469076e-03	2.460
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.469076e-03	2.460
Signaling by VEGF	R-HSA-194138	3.482744e-03	2.458
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	3.594047e-03	2.444
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.594047e-03	2.444
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.594047e-03	2.444
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.667900e-03	2.436
HDACs deacetylate histones	R-HSA-3214815	3.667900e-03	2.436
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.697549e-03	2.432
Regulation of CDH11 function	R-HSA-9762292	3.697549e-03	2.432
Pexophagy	R-HSA-9664873	3.697549e-03	2.432
Dual Incision in GG-NER	R-HSA-5696400	3.881998e-03	2.411
Nuclear import of Rev protein	R-HSA-180746	3.881998e-03	2.411
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.881998e-03	2.411
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.881998e-03	2.411
Signaling by NOTCH	R-HSA-157118	3.969747e-03	2.401
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.056724e-03	2.392
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.056724e-03	2.392
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.852934e-03	2.314
Signaling by EGFR in Cancer	R-HSA-1643713	4.697126e-03	2.328
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	4.415219e-03	2.355
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.415219e-03	2.355
Asymmetric localization of PCP proteins	R-HSA-4608870	4.351590e-03	2.361
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.001961e-03	2.301
Defective CFTR causes cystic fibrosis	R-HSA-5678895	4.351590e-03	2.361
HIV Infection	R-HSA-162906	4.418311e-03	2.355
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.783502e-03	2.320
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.792822e-03	2.319
Regulation of Apoptosis	R-HSA-169911	4.415219e-03	2.355
Signaling by Interleukins	R-HSA-449147	4.958802e-03	2.305
SARS-CoV Infections	R-HSA-9679506	4.790597e-03	2.320
Regulation of mitotic cell cycle	R-HSA-453276	5.213704e-03	2.283
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.213704e-03	2.283
Hedgehog 'on' state	R-HSA-5632684	5.213704e-03	2.283
Intracellular signaling by second messengers	R-HSA-9006925	5.274363e-03	2.278
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.281074e-03	2.277
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.397367e-03	2.268
Ovarian tumor domain proteases	R-HSA-5689896	5.645453e-03	2.248
Degradation of DVL	R-HSA-4641258	5.645453e-03	2.248
Degradation of AXIN	R-HSA-4641257	5.645453e-03	2.248
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.645453e-03	2.248
Transcriptional regulation by small RNAs	R-HSA-5578749	5.673626e-03	2.246
Mitotic Prophase	R-HSA-68875	5.767549e-03	2.239
Kinesins	R-HSA-983189	5.943732e-03	2.226
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.996206e-03	2.222
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.052680e-03	2.218
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.087108e-03	2.216
NF-kB is activated and signals survival	R-HSA-209560	6.087108e-03	2.216
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.127130e-03	2.213
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.246835e-03	2.204
Translesion Synthesis by POLH	R-HSA-110320	6.246835e-03	2.204
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.248295e-03	2.204
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.879227e-03	2.162
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.594884e-03	2.119
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.594884e-03	2.119
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.149924e-03	2.146
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.115714e-03	2.148
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	7.115714e-03	2.148
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	7.949018e-03	2.100
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.245324e-03	2.140
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.680845e-03	2.115
mRNA Splicing - Major Pathway	R-HSA-72163	7.668552e-03	2.115
DNA Damage Bypass	R-HSA-73893	6.624766e-03	2.179
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.624766e-03	2.179
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.149924e-03	2.146
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.110344e-03	2.148
Interactions of Rev with host cellular proteins	R-HSA-177243	7.949018e-03	2.100
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.115714e-03	2.148
Transcriptional regulation by RUNX3	R-HSA-8878159	6.430033e-03	2.192
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.594884e-03	2.119
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.594884e-03	2.119
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.115714e-03	2.148
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.949018e-03	2.100
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.949018e-03	2.100
TCR signaling	R-HSA-202403	6.538639e-03	2.185
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.110344e-03	2.148
Stabilization of p53	R-HSA-69541	7.115714e-03	2.148
IRAK1 recruits IKK complex	R-HSA-937039	7.594884e-03	2.119
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.594884e-03	2.119
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.879227e-03	2.162
Glycogen synthesis	R-HSA-3322077	7.374295e-03	2.132
Programmed Cell Death	R-HSA-5357801	6.576220e-03	2.182
Activation of NF-kappaB in B cells	R-HSA-1169091	8.052514e-03	2.094
Hedgehog ligand biogenesis	R-HSA-5358346	8.052514e-03	2.094
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.142010e-03	2.089
HCMV Early Events	R-HSA-9609690	8.406875e-03	2.075
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.636273e-03	2.064
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.852124e-03	2.053
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.852124e-03	2.053
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.852124e-03	2.053
Unfolded Protein Response (UPR)	R-HSA-381119	8.961179e-03	2.048
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.984122e-03	2.047
Oxidative Stress Induced Senescence	R-HSA-2559580	8.984122e-03	2.047
PCP/CE pathway	R-HSA-4086400	9.134162e-03	2.039
Cellular response to hypoxia	R-HSA-1234174	9.178975e-03	2.037
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.229304e-03	2.035
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.229304e-03	2.035
Evasion by RSV of host interferon responses	R-HSA-9833109	9.229304e-03	2.035
Platelet degranulation	R-HSA-114608	9.270805e-03	2.033
G2/M Checkpoints	R-HSA-69481	9.270805e-03	2.033
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.329550e-03	2.030
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.460154e-03	2.024
Regulation of PTEN stability and activity	R-HSA-8948751	9.699539e-03	2.013
Degradation of CRY and PER proteins	R-HSA-9932298	9.828277e-03	2.008
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.828277e-03	2.008
Notch-HLH transcription pathway	R-HSA-350054	1.159301e-02	1.936
IPs transport between nucleus and cytosol	R-HSA-1855170	1.170810e-02	1.932
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.170810e-02	1.932
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.310862e-02	1.882
mRNA Splicing	R-HSA-72172	1.246981e-02	1.904
Nucleotide Excision Repair	R-HSA-5696398	1.154619e-02	1.938
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.130336e-02	1.947
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.004015e-02	1.998
Cation-coupled Chloride cotransporters	R-HSA-426117	1.253459e-02	1.902
Late Phase of HIV Life Cycle	R-HSA-162599	1.106407e-02	1.956
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.130336e-02	1.947
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.020302e-02	1.991
Interferon alpha/beta signaling	R-HSA-909733	1.006974e-02	1.997
PIP3 activates AKT signaling	R-HSA-1257604	1.016375e-02	1.993
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.004015e-02	1.998
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.061121e-02	1.974
HIV Life Cycle	R-HSA-162587	1.105133e-02	1.957
NRIF signals cell death from the nucleus	R-HSA-205043	1.130336e-02	1.947
Regulation of necroptotic cell death	R-HSA-5675482	1.170810e-02	1.932
Uptake and function of diphtheria toxin	R-HSA-5336415	1.253459e-02	1.902
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.310862e-02	1.882
Processing of DNA double-strand break ends	R-HSA-5693607	1.137850e-02	1.944
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.041648e-02	1.982
Immune System	R-HSA-168256	1.273462e-02	1.895
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.322700e-02	1.879
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.159301e-02	1.936
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.130336e-02	1.947
Assembly of the pre-replicative complex	R-HSA-68867	1.159489e-02	1.936
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.106407e-02	1.956
Transcriptional Regulation by TP53	R-HSA-3700989	1.125906e-02	1.948
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.170810e-02	1.932
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.352738e-02	1.869
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.352738e-02	1.869
Translesion synthesis by REV1	R-HSA-110312	1.352738e-02	1.869
Protein methylation	R-HSA-8876725	1.352738e-02	1.869
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.352738e-02	1.869
Spry regulation of FGF signaling	R-HSA-1295596	1.352738e-02	1.869
Membrane Trafficking	R-HSA-199991	1.377216e-02	1.861
Chromosome Maintenance	R-HSA-73886	1.414941e-02	1.849
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.452710e-02	1.838
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.452710e-02	1.838
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.452710e-02	1.838
Neutrophil degranulation	R-HSA-6798695	1.456502e-02	1.837
Signaling by NOTCH2	R-HSA-1980145	1.462237e-02	1.835
Mitophagy	R-HSA-5205647	1.462237e-02	1.835
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.462237e-02	1.835
Gap junction assembly	R-HSA-190861	1.462237e-02	1.835
DNA Replication Pre-Initiation	R-HSA-69002	1.463672e-02	1.835
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.464240e-02	1.834
Dual incision in TC-NER	R-HSA-6782135	1.490030e-02	1.827
COPI-mediated anterograde transport	R-HSA-6807878	1.494717e-02	1.825
Deadenylation of mRNA	R-HSA-429947	1.517230e-02	1.819
Cell Cycle Checkpoints	R-HSA-69620	1.566219e-02	1.805
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.591586e-02	1.798
Gene expression (Transcription)	R-HSA-74160	1.595957e-02	1.797
Translesion synthesis by POLI	R-HSA-5656121	1.601144e-02	1.796
Regulation of BACH1 activity	R-HSA-9708530	1.601144e-02	1.796
Type I hemidesmosome assembly	R-HSA-446107	1.611633e-02	1.793
Formation of annular gap junctions	R-HSA-196025	1.611633e-02	1.793
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.611633e-02	1.793
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.625351e-02	1.789
Beta-catenin independent WNT signaling	R-HSA-3858494	1.660068e-02	1.780
XBP1(S) activates chaperone genes	R-HSA-381038	1.708874e-02	1.767
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.739623e-02	1.760
Signaling by ERBB2	R-HSA-1227986	1.746244e-02	1.758
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.746244e-02	1.758
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.746244e-02	1.758
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.746244e-02	1.758
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.746244e-02	1.758
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.746244e-02	1.758
Regulation of TP53 Degradation	R-HSA-6804757	1.800605e-02	1.745
MAPK1/MAPK3 signaling	R-HSA-5684996	1.858343e-02	1.731
Translesion synthesis by POLK	R-HSA-5655862	1.876412e-02	1.727
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.885570e-02	1.725
DNA Replication	R-HSA-69306	1.887121e-02	1.724
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.897106e-02	1.722
Gluconeogenesis	R-HSA-70263	1.897106e-02	1.722
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.942350e-02	1.712
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.988380e-02	1.702
Gap junction degradation	R-HSA-190873	2.021384e-02	1.694
ALK mutants bind TKIs	R-HSA-9700645	2.021384e-02	1.694
Cellular response to mitochondrial stress	R-HSA-9840373	2.021384e-02	1.694
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.021384e-02	1.694
ER-Phagosome pathway	R-HSA-1236974	2.063135e-02	1.685
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.064310e-02	1.685
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.064310e-02	1.685
Signaling by NOTCH1	R-HSA-1980143	2.077551e-02	1.682
Regulation of FZD by ubiquitination	R-HSA-4641263	2.179275e-02	1.662
Glycogen storage diseases	R-HSA-3229121	2.179275e-02	1.662
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.181470e-02	1.661
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.187724e-02	1.660
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.189041e-02	1.660
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.189041e-02	1.660
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.402930e-02	1.619
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.428939e-02	1.615
Folding of actin by CCT/TriC	R-HSA-390450	2.483084e-02	1.605
Ephrin signaling	R-HSA-3928664	2.510343e-02	1.600
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.258918e-02	1.487
Late endosomal microautophagy	R-HSA-9615710	2.715162e-02	1.566
Trafficking of AMPA receptors	R-HSA-399719	3.325353e-02	1.478
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.626864e-02	1.581
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.835509e-02	1.547
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.034768e-02	1.518
EPH-Ephrin signaling	R-HSA-2682334	2.615075e-02	1.583
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.630368e-02	1.580
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.677042e-02	1.435
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.871655e-02	1.542
Telomere Maintenance	R-HSA-157579	3.629890e-02	1.440
Termination of translesion DNA synthesis	R-HSA-5656169	2.715162e-02	1.566
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.364170e-02	1.473
Budding and maturation of HIV virion	R-HSA-162588	3.325353e-02	1.478
MTF1 activates gene expression	R-HSA-5660489	3.364170e-02	1.473
Orc1 removal from chromatin	R-HSA-68949	2.626864e-02	1.581
Golgi-to-ER retrograde transport	R-HSA-8856688	2.721038e-02	1.565
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.444305e-02	1.463
Platelet activation, signaling and aggregation	R-HSA-76002	2.701698e-02	1.568
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.512472e-02	1.454
RAF/MAP kinase cascade	R-HSA-5673001	2.547070e-02	1.594
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.715162e-02	1.566
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.285828e-02	1.483
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.352379e-02	1.475
Negative regulation of MAPK pathway	R-HSA-5675221	3.127067e-02	1.505
MAPK family signaling cascades	R-HSA-5683057	3.104155e-02	1.508
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.870102e-02	1.542
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.677042e-02	1.435
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.512472e-02	1.454
EGFR downregulation	R-HSA-182971	3.325353e-02	1.478
Transcriptional regulation by RUNX1	R-HSA-8878171	2.897419e-02	1.538
Signaling by TGFB family members	R-HSA-9006936	2.567553e-02	1.590
Homology Directed Repair	R-HSA-5693538	2.637072e-02	1.579
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.630368e-02	1.580
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.871655e-02	1.542
Mitochondrial biogenesis	R-HSA-1592230	2.508562e-02	1.601
FLT3 Signaling	R-HSA-9607240	2.871655e-02	1.542
Cyclin E associated events during G1/S transition	R-HSA-69202	3.512472e-02	1.454
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.677042e-02	1.435
Apoptosis induced DNA fragmentation	R-HSA-140342	2.483084e-02	1.605
Regulation of signaling by CBL	R-HSA-912631	2.870102e-02	1.542
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	3.677042e-02	1.435
Response of Mtb to phagocytosis	R-HSA-9637690	3.681247e-02	1.434
MAPK6/MAPK4 signaling	R-HSA-5687128	3.613432e-02	1.442
Gene Silencing by RNA	R-HSA-211000	2.938653e-02	1.532
IRE1alpha activates chaperones	R-HSA-381070	2.468170e-02	1.608
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.510343e-02	1.600
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.891634e-02	1.539
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.557098e-02	1.449
HCMV Infection	R-HSA-9609646	3.685210e-02	1.434
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.822034e-02	1.418
Generic Transcription Pathway	R-HSA-212436	3.870642e-02	1.412
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.973023e-02	1.401
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.973023e-02	1.401
EPHB-mediated forward signaling	R-HSA-3928662	3.980446e-02	1.400
Proteasome assembly	R-HSA-9907900	3.980446e-02	1.400
RMTs methylate histone arginines	R-HSA-3214858	3.980446e-02	1.400
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.014437e-02	1.396
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.014437e-02	1.396
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.038689e-02	1.394
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.046771e-02	1.393
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.124612e-02	1.385
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.124612e-02	1.385
Assembly Of The HIV Virion	R-HSA-175474	4.124612e-02	1.385
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.139533e-02	1.383
RNA Polymerase II Transcription	R-HSA-73857	4.166013e-02	1.380
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.217714e-02	1.375
Switching of origins to a post-replicative state	R-HSA-69052	4.217714e-02	1.375
ABC-family proteins mediated transport	R-HSA-382556	4.227998e-02	1.374
Nucleosome assembly	R-HSA-774815	4.294628e-02	1.367
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.294628e-02	1.367
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.294628e-02	1.367
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.294628e-02	1.367
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.323881e-02	1.364
Deadenylation-dependent mRNA decay	R-HSA-429914	4.323881e-02	1.364
Striated Muscle Contraction	R-HSA-390522	4.389100e-02	1.358
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.389100e-02	1.358
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.440258e-02	1.353
Nectin/Necl trans heterodimerization	R-HSA-420597	4.440258e-02	1.353
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.512403e-02	1.346
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.537140e-02	1.343
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.601656e-02	1.337
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.612959e-02	1.336
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	4.623945e-02	1.335
Regulation of TNFR1 signaling	R-HSA-5357905	4.623945e-02	1.335
Regulation of pyruvate metabolism	R-HSA-9861718	4.623945e-02	1.335
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.639730e-02	1.334
Regulation of endogenous retroelements	R-HSA-9842860	4.662125e-02	1.331
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.784032e-02	1.320
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.843194e-02	1.315
Viral Messenger RNA Synthesis	R-HSA-168325	4.914124e-02	1.309
MAP kinase activation	R-HSA-450294	4.914124e-02	1.309
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.968523e-02	1.304
Downstream TCR signaling	R-HSA-202424	4.987927e-02	1.302
tRNA processing in the nucleus	R-HSA-6784531	5.227480e-02	1.282
RSV-host interactions	R-HSA-9833110	5.368036e-02	1.270
Circadian clock	R-HSA-9909396	5.392096e-02	1.268
Signaling by WNT	R-HSA-195721	5.455295e-02	1.263
G1/S DNA Damage Checkpoints	R-HSA-69615	5.553114e-02	1.255
Signaling by PTK6	R-HSA-8848021	5.553114e-02	1.255
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.553114e-02	1.255
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.557247e-02	1.255
Signal regulatory protein family interactions	R-HSA-391160	5.557247e-02	1.255
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.589864e-02	1.253
ABC transporter disorders	R-HSA-5619084	5.589864e-02	1.253
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.624509e-02	1.250
FLT3 signaling in disease	R-HSA-9682385	5.634979e-02	1.249
Transcriptional regulation by RUNX2	R-HSA-8878166	5.643286e-02	1.248
S Phase	R-HSA-69242	5.750526e-02	1.240
Organelle biogenesis and maintenance	R-HSA-1852241	6.105918e-02	1.214
Synthesis of DNA	R-HSA-69239	6.141245e-02	1.212
Tight junction interactions	R-HSA-420029	6.208408e-02	1.207
SWI/SNF chromatin remodelers	R-HSA-9932451	6.208408e-02	1.207
ATP-dependent chromatin remodelers	R-HSA-9932444	6.208408e-02	1.207
Signaling by MET	R-HSA-6806834	6.209758e-02	1.207
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.209758e-02	1.207
TCF dependent signaling in response to WNT	R-HSA-201681	6.290400e-02	1.201
Antigen processing-Cross presentation	R-HSA-1236975	6.414199e-02	1.193
Amyloid fiber formation	R-HSA-977225	6.535184e-02	1.185
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.535184e-02	1.185
Epigenetic regulation of gene expression	R-HSA-212165	6.577770e-02	1.182
Myogenesis	R-HSA-525793	6.801655e-02	1.167
Suppression of phagosomal maturation	R-HSA-9637687	6.801655e-02	1.167
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.870985e-02	1.163
DNA Double-Strand Break Repair	R-HSA-5693532	6.887592e-02	1.162
RNA Polymerase I Promoter Escape	R-HSA-73772	6.922909e-02	1.160
Formation of RNA Pol II elongation complex	R-HSA-112382	6.922909e-02	1.160
DNA Double Strand Break Response	R-HSA-5693606	6.979635e-02	1.156
Plasma lipoprotein clearance	R-HSA-8964043	7.063938e-02	1.151
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	7.124750e-02	1.147
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.360244e-02	1.133
Smooth Muscle Contraction	R-HSA-445355	7.360244e-02	1.133
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.423077e-02	1.129
Interaction between L1 and Ankyrins	R-HSA-445095	7.423077e-02	1.129
Cristae formation	R-HSA-8949613	7.423077e-02	1.129
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.423077e-02	1.129
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.423077e-02	1.129
Inhibition of DNA recombination at telomere	R-HSA-9670095	7.580578e-02	1.120
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.580578e-02	1.120
Glycogen metabolism	R-HSA-8982491	7.580578e-02	1.120
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.641066e-02	1.117
Infectious disease	R-HSA-5663205	7.885956e-02	1.103
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.965919e-02	1.099
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.965919e-02	1.099
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.965919e-02	1.099
HIV elongation arrest and recovery	R-HSA-167287	8.072165e-02	1.093
Pausing and recovery of HIV elongation	R-HSA-167290	8.072165e-02	1.093
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.072165e-02	1.093
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.117106e-02	1.091
Interleukin-17 signaling	R-HSA-448424	8.180381e-02	1.087
Cohesin Loading onto Chromatin	R-HSA-2470946	8.269107e-02	1.083
Recycling of eIF2:GDP	R-HSA-72731	8.269107e-02	1.083
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	8.269107e-02	1.083
Signaling by NOTCH3	R-HSA-9012852	8.281099e-02	1.082
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.333189e-02	1.079
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.605492e-02	1.065
Translation of Structural Proteins	R-HSA-9683701	8.673300e-02	1.062
Developmental Cell Lineages	R-HSA-9734767	8.712396e-02	1.060
Regulation of TP53 Activity	R-HSA-5633007	8.712553e-02	1.060
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.748338e-02	1.058
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.748338e-02	1.058
Regulation of gene expression in beta cells	R-HSA-210745	8.748338e-02	1.058
TNF signaling	R-HSA-75893	8.764442e-02	1.057
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.764442e-02	1.057
Signaling by EGFR	R-HSA-177929	8.764442e-02	1.057
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.064457e-02	1.043
Diseases of Telomere Maintenance	R-HSA-9673013	9.064457e-02	1.043
Drug-mediated inhibition of MET activation	R-HSA-9734091	9.064457e-02	1.043
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.064457e-02	1.043
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.064457e-02	1.043
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.064457e-02	1.043
Interactions of Tat with host cellular proteins	R-HSA-176034	1.328413e-01	0.877
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.328413e-01	0.877
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.328413e-01	0.877
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	1.328413e-01	0.877
Defective GFPT1 causes CMSTA1	R-HSA-4085023	1.328413e-01	0.877
PTEN Loss of Function in Cancer	R-HSA-5674404	1.328413e-01	0.877
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.730825e-01	0.762
Defective AHCY causes HMAHCHD	R-HSA-5578997	1.730825e-01	0.762
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.730825e-01	0.762
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	1.730825e-01	0.762
Lipophagy	R-HSA-9613354	1.120992e-01	0.950
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	1.120992e-01	0.950
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	1.120992e-01	0.950
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.276743e-01	0.894
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.866487e-02	1.052
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.797881e-02	1.009
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.797881e-02	1.009
Signaling by ERBB2 in Cancer	R-HSA-1227990	9.450951e-02	1.025
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.387803e-01	0.858
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.387803e-01	0.858
FGFR2 alternative splicing	R-HSA-6803529	1.497583e-01	0.825
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.497583e-01	0.825
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.248898e-02	1.034
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.724936e-01	0.763
RAF activation	R-HSA-5673000	1.333419e-01	0.875
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.256155e-01	0.901
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.256155e-01	0.901
Protein ubiquitination	R-HSA-8852135	1.042870e-01	0.982
AURKA Activation by TPX2	R-HSA-8854518	1.439856e-01	0.842
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.702506e-01	0.769
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.640012e-01	0.785
Amplification of signal from the kinetochores	R-HSA-141424	1.640012e-01	0.785
Mitotic Spindle Checkpoint	R-HSA-69618	1.627335e-01	0.789
RNA Polymerase I Transcription	R-HSA-73864	1.192225e-01	0.924
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.091474e-01	0.962
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.276743e-01	0.894
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.601497e-01	0.795
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.093262e-01	0.961
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.417895e-01	0.848
Inhibition of PKR	R-HSA-169131	9.064457e-02	1.043
Manipulation of host energy metabolism	R-HSA-9636667	1.328413e-01	0.877
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.730825e-01	0.762
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.601497e-01	0.795
Intraflagellar transport	R-HSA-5620924	1.309110e-01	0.883
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.066937e-01	0.972
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.066937e-01	0.972
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.183757e-01	0.927
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.183757e-01	0.927
Response of endothelial cells to shear stress	R-HSA-9860931	1.017928e-01	0.992
Vesicle-mediated transport	R-HSA-5653656	1.235675e-01	0.908
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.027629e-01	0.988
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.270906e-01	0.896
DNA Repair	R-HSA-73894	1.008044e-01	0.997
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.456474e-01	0.837
Interleukin-1 signaling	R-HSA-9020702	9.032527e-02	1.044
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.171012e-01	0.931
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.047113e-01	0.980
Cellular responses to mechanical stimuli	R-HSA-9855142	1.504895e-01	0.822
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.456474e-01	0.837
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.604095e-01	0.795
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.316059e-01	0.881
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.226594e-01	0.911
MyD88-independent TLR4 cascade	R-HSA-166166	1.316059e-01	0.881
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.098789e-01	0.959
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.610034e-01	0.793
GP1b-IX-V activation signalling	R-HSA-430116	1.120992e-01	0.950
Metabolism of non-coding RNA	R-HSA-194441	1.030459e-01	0.987
snRNP Assembly	R-HSA-191859	1.030459e-01	0.987
Co-inhibition by PD-1	R-HSA-389948	1.652836e-01	0.782
Muscle contraction	R-HSA-397014	9.220640e-02	1.035
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.017930e-01	0.992
Uptake and actions of bacterial toxins	R-HSA-5339562	1.599152e-01	0.796
Estrogen-dependent gene expression	R-HSA-9018519	1.176395e-01	0.929
Protein hydroxylation	R-HSA-9629569	1.177136e-01	0.929
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.220640e-02	1.035
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.240643e-01	0.906
ER to Golgi Anterograde Transport	R-HSA-199977	9.952242e-02	1.002
NOD1/2 Signaling Pathway	R-HSA-168638	1.333419e-01	0.875
Iron uptake and transport	R-HSA-917937	1.042870e-01	0.982
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.080015e-01	0.967
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.276743e-01	0.894
Regulation of T cell activation by CD28 family	R-HSA-388841	1.708036e-01	0.768
Cyclin D associated events in G1	R-HSA-69231	1.045709e-01	0.981
G1 Phase	R-HSA-69236	1.045709e-01	0.981
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.276743e-01	0.894
Neurodegenerative Diseases	R-HSA-8863678	1.724936e-01	0.763
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.724936e-01	0.763
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.379245e-01	0.860
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.333419e-01	0.875
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.045709e-01	0.981
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	9.707471e-02	1.013
Respiratory syncytial virus genome replication	R-HSA-9834752	1.120992e-01	0.950
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.601497e-01	0.795
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.171012e-01	0.931
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.599152e-01	0.796
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.702506e-01	0.769
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.316060e-01	0.881
SLC-mediated transport of inorganic anions	R-HSA-9958790	1.683269e-01	0.774
Regulated Necrosis	R-HSA-5218859	1.568760e-01	0.804
Pyruvate metabolism	R-HSA-70268	1.762330e-01	0.754
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	1.464033e-01	0.834
Inositol phosphate metabolism	R-HSA-1483249	1.408853e-01	0.851
Calnexin/calreticulin cycle	R-HSA-901042	1.333419e-01	0.875
Nuclear Envelope Breakdown	R-HSA-2980766	9.262905e-02	1.033
Signaling by FGFR2	R-HSA-5654738	1.297602e-01	0.887
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.601497e-01	0.795
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.333419e-01	0.875
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.417895e-01	0.848
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.120992e-01	0.950
Stimuli-sensing channels	R-HSA-2672351	1.226594e-01	0.911
Signaling by ERBB4	R-HSA-1236394	9.954653e-02	1.002
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.486709e-01	0.828
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.610034e-01	0.793
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.248898e-02	1.034
Disorders of transmembrane transporters	R-HSA-5619115	1.408050e-01	0.851
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.769026e-01	0.752
NoRC negatively regulates rRNA expression	R-HSA-427413	1.771105e-01	0.752
Pentose phosphate pathway	R-HSA-71336	1.775379e-01	0.751
RAS processing	R-HSA-9648002	1.775379e-01	0.751
Potential therapeutics for SARS	R-HSA-9679191	1.811962e-01	0.742
MITF-M-dependent gene expression	R-HSA-9856651	1.811962e-01	0.742
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	1.840806e-01	0.735
Sema4D in semaphorin signaling	R-HSA-400685	1.842074e-01	0.735
Long-term potentiation	R-HSA-9620244	1.842074e-01	0.735
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.869146e-01	0.728
Generation of second messenger molecules	R-HSA-202433	1.869146e-01	0.728
Interleukin-1 family signaling	R-HSA-446652	1.907074e-01	0.720
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.911569e-01	0.719
Ion homeostasis	R-HSA-5578775	1.912491e-01	0.718
Formation of axial mesoderm	R-HSA-9796292	1.939106e-01	0.712
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.939106e-01	0.712
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.939106e-01	0.712
Base Excision Repair	R-HSA-73884	1.952794e-01	0.709
PKMTs methylate histone lysines	R-HSA-3214841	1.964466e-01	0.707
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.964466e-01	0.707
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.983355e-01	0.703
G2/M DNA damage checkpoint	R-HSA-69473	1.983355e-01	0.703
C-type lectin receptors (CLRs)	R-HSA-5621481	1.984010e-01	0.702
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.004400e-01	0.698
Transcriptional Regulation by MECP2	R-HSA-8986944	2.018036e-01	0.695
Toll-like Receptor Cascades	R-HSA-168898	2.049550e-01	0.688
Centrosome maturation	R-HSA-380287	2.056124e-01	0.687
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.082205e-01	0.681
Packaging Of Telomere Ends	R-HSA-171306	2.082205e-01	0.681
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.082205e-01	0.681
RNA Polymerase I Promoter Opening	R-HSA-73728	2.082205e-01	0.681
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.082205e-01	0.681
MHC class II antigen presentation	R-HSA-2132295	2.086671e-01	0.681
Acyl chain remodeling of CL	R-HSA-1482798	2.111139e-01	0.675
STAT6-mediated induction of chemokines	R-HSA-3249367	2.114585e-01	0.675
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.114585e-01	0.675
IRAK4 deficiency (TLR5)	R-HSA-5603037	2.114585e-01	0.675
MET activates PTPN11	R-HSA-8865999	2.114585e-01	0.675
MET activates STAT3	R-HSA-8875791	2.114585e-01	0.675
Intracellular oxygen transport	R-HSA-8981607	2.114585e-01	0.675
HCMV Late Events	R-HSA-9610379	2.154349e-01	0.667
Ca-dependent events	R-HSA-111996	2.159355e-01	0.666
Cleavage of the damaged pyrimidine	R-HSA-110329	2.159355e-01	0.666
Depyrimidination	R-HSA-73928	2.159355e-01	0.666
Extension of Telomeres	R-HSA-180786	2.160544e-01	0.665
Peroxisomal protein import	R-HSA-9033241	2.160544e-01	0.665
Regulation of beta-cell development	R-HSA-186712	2.160544e-01	0.665
MITF-M-regulated melanocyte development	R-HSA-9730414	2.238182e-01	0.650
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.245387e-01	0.649
Signaling by FGFR4	R-HSA-5654743	2.258717e-01	0.646
G1/S Transition	R-HSA-69206	2.259379e-01	0.646
Processive synthesis on the lagging strand	R-HSA-69183	2.284579e-01	0.641
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.328768e-01	0.633
DNA methylation	R-HSA-5334118	2.328768e-01	0.633
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.328768e-01	0.633
Platelet calcium homeostasis	R-HSA-418360	2.328768e-01	0.633
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.328768e-01	0.633
Formation of paraxial mesoderm	R-HSA-9793380	2.331206e-01	0.632
PLC beta mediated events	R-HSA-112043	2.331206e-01	0.632
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.356092e-01	0.628
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.433264e-01	0.614
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.433264e-01	0.614
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.453965e-01	0.610
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.453965e-01	0.610
ESR-mediated signaling	R-HSA-8939211	2.458739e-01	0.609
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.458926e-01	0.609
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.458926e-01	0.609
Fanconi Anemia Pathway	R-HSA-6783310	2.460762e-01	0.609
Somitogenesis	R-HSA-9824272	2.460762e-01	0.609
DAG and IP3 signaling	R-HSA-1489509	2.460762e-01	0.609
Signaling by FGFR3	R-HSA-5654741	2.460762e-01	0.609
HCN channels	R-HSA-1296061	2.480558e-01	0.605
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.480558e-01	0.605
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.480558e-01	0.605
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.480558e-01	0.605
Defective LFNG causes SCDO3	R-HSA-5083630	2.480558e-01	0.605
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.480558e-01	0.605
Regulation of gap junction activity	R-HSA-191650	2.480558e-01	0.605
mRNA Splicing - Minor Pathway	R-HSA-72165	2.563242e-01	0.591
Condensation of Prophase Chromosomes	R-HSA-2299718	2.563242e-01	0.591
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.617972e-01	0.582
G beta:gamma signalling through CDC42	R-HSA-8964616	2.633724e-01	0.579
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.633724e-01	0.579
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.633724e-01	0.579
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.633724e-01	0.579
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.633724e-01	0.579
Galactose catabolism	R-HSA-70370	2.633724e-01	0.579
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.633724e-01	0.579
Response to metal ions	R-HSA-5660526	2.633724e-01	0.579
Signaling by FGFR	R-HSA-190236	2.638915e-01	0.579
Metabolism of proteins	R-HSA-392499	2.678653e-01	0.572
Diseases of mitotic cell cycle	R-HSA-9675126	2.707244e-01	0.567
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.707244e-01	0.567
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.734007e-01	0.563
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.770615e-01	0.557
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.772719e-01	0.557
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.808555e-01	0.552
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.808555e-01	0.552
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.808555e-01	0.552
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.808555e-01	0.552
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.808555e-01	0.552
Transmission across Chemical Synapses	R-HSA-112315	2.809640e-01	0.551
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.829567e-01	0.548
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.829567e-01	0.548
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.829567e-01	0.548
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.829567e-01	0.548
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	2.829567e-01	0.548
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.829567e-01	0.548
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.829567e-01	0.548
Muscarinic acetylcholine receptors	R-HSA-390648	2.829567e-01	0.548
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.829567e-01	0.548
Integrin signaling	R-HSA-354192	2.834966e-01	0.547
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.834966e-01	0.547
Activation of ATR in response to replication stress	R-HSA-176187	2.834966e-01	0.547
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.834966e-01	0.547
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.834966e-01	0.547
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.834966e-01	0.547
Regulation of MECP2 expression and activity	R-HSA-9022692	2.834966e-01	0.547
G-protein mediated events	R-HSA-112040	2.863067e-01	0.543
Ion channel transport	R-HSA-983712	2.889957e-01	0.539
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.936485e-01	0.532
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.963181e-01	0.528
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.963181e-01	0.528
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.983041e-01	0.525
Mismatch Repair	R-HSA-5358508	2.983041e-01	0.525
Nephron development	R-HSA-9831926	2.983041e-01	0.525
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.990675e-01	0.524
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	2.990675e-01	0.524
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.091726e-01	0.510
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.091726e-01	0.510
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.091726e-01	0.510
Diseases of programmed cell death	R-HSA-9645723	3.154414e-01	0.501
Pre-NOTCH Processing in Golgi	R-HSA-1912420	3.156838e-01	0.501
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.156838e-01	0.501
Germ layer formation at gastrulation	R-HSA-9754189	3.156838e-01	0.501
The NLRP3 inflammasome	R-HSA-844456	3.156838e-01	0.501
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.162397e-01	0.500
Noncanonical activation of NOTCH3	R-HSA-9017802	3.162397e-01	0.500
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.162397e-01	0.500
CLEC7A/inflammasome pathway	R-HSA-5660668	3.162397e-01	0.500
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.162397e-01	0.500
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.162397e-01	0.500
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	3.162397e-01	0.500
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.162397e-01	0.500
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.162397e-01	0.500
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.162397e-01	0.500
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.193673e-01	0.496
PERK regulates gene expression	R-HSA-381042	3.220443e-01	0.492
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.220443e-01	0.492
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.229208e-01	0.491
Innate Immune System	R-HSA-168249	3.250410e-01	0.488
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	3.286237e-01	0.483
Meiotic synapsis	R-HSA-1221632	3.298649e-01	0.482
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.298649e-01	0.482
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.319511e-01	0.479
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.321631e-01	0.479
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.321631e-01	0.479
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.329634e-01	0.478
Signal transduction by L1	R-HSA-445144	3.329634e-01	0.478
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.349184e-01	0.475
PRC2 methylates histones and DNA	R-HSA-212300	3.349184e-01	0.475
RNA Polymerase III Transcription	R-HSA-74158	3.349184e-01	0.475
RUNX2 regulates bone development	R-HSA-8941326	3.349184e-01	0.475
Calmodulin induced events	R-HSA-111933	3.349184e-01	0.475
CaM pathway	R-HSA-111997	3.349184e-01	0.475
Metabolism of amino acids and derivatives	R-HSA-71291	3.369620e-01	0.472
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.405167e-01	0.468
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.477804e-01	0.459
Cleavage of the damaged purine	R-HSA-110331	3.477804e-01	0.459
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.479797e-01	0.458
STAT5 Activation	R-HSA-9645135	3.479797e-01	0.458
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	3.479797e-01	0.458
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.479797e-01	0.458
MET Receptor Activation	R-HSA-6806942	3.479797e-01	0.458
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	3.479797e-01	0.458
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	3.479797e-01	0.458
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.479797e-01	0.458
CREB phosphorylation	R-HSA-199920	3.479797e-01	0.458
Lagging Strand Synthesis	R-HSA-69186	3.501149e-01	0.456
MET promotes cell motility	R-HSA-8875878	3.606169e-01	0.443
Depurination	R-HSA-73927	3.606169e-01	0.443
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.606169e-01	0.443
Transport to the Golgi and subsequent modification	R-HSA-948021	3.607421e-01	0.443
Neddylation	R-HSA-8951664	3.608284e-01	0.443
Signaling by FGFR1	R-HSA-5654736	3.618424e-01	0.441
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.671129e-01	0.435
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	3.671129e-01	0.435
Ribavirin ADME	R-HSA-9755088	3.671129e-01	0.435
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.734149e-01	0.428
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	3.734149e-01	0.428
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.734149e-01	0.428
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.734149e-01	0.428
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.781687e-01	0.422
RUNX3 regulates WNT signaling	R-HSA-8951430	3.782482e-01	0.422
MET activates PI3K/AKT signaling	R-HSA-8851907	3.782482e-01	0.422
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.782482e-01	0.422
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.782482e-01	0.422
IFNG signaling activates MAPKs	R-HSA-9732724	3.782482e-01	0.422
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	3.782482e-01	0.422
Disinhibition of SNARE formation	R-HSA-114516	3.782482e-01	0.422
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.782482e-01	0.422
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.782482e-01	0.422
PTK6 Expression	R-HSA-8849473	3.782482e-01	0.422
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.782482e-01	0.422
Synthesis of PIPs in the nucleus	R-HSA-8847453	3.782482e-01	0.422
CHL1 interactions	R-HSA-447041	3.782482e-01	0.422
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.782482e-01	0.422
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.782482e-01	0.422
Translation of Structural Proteins	R-HSA-9694635	3.786190e-01	0.422
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.839348e-01	0.416
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.839348e-01	0.416
Neurotoxicity of clostridium toxins	R-HSA-168799	3.839348e-01	0.416
Fructose metabolism	R-HSA-5652084	3.839348e-01	0.416
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.839348e-01	0.416
HIV Transcription Elongation	R-HSA-167169	3.861621e-01	0.413
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.861621e-01	0.413
Nuclear signaling by ERBB4	R-HSA-1251985	3.861621e-01	0.413
Adaptive Immune System	R-HSA-1280218	3.887285e-01	0.410
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.988470e-01	0.399
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.005603e-01	0.397
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.005603e-01	0.397
Regulation of PTEN mRNA translation	R-HSA-8943723	4.005603e-01	0.397
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.005603e-01	0.397
Syndecan interactions	R-HSA-3000170	4.005603e-01	0.397
Extracellular matrix organization	R-HSA-1474244	4.043525e-01	0.393
Metabolism of polyamines	R-HSA-351202	4.043612e-01	0.393
phospho-PLA2 pathway	R-HSA-111995	4.071133e-01	0.390
MET receptor recycling	R-HSA-8875656	4.071133e-01	0.390
Signaling by MRAS-complex mutants	R-HSA-9660537	4.071133e-01	0.390
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.071133e-01	0.390
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.071133e-01	0.390
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	4.071133e-01	0.390
Interleukin-23 signaling	R-HSA-9020933	4.071133e-01	0.390
Fructose biosynthesis	R-HSA-5652227	4.071133e-01	0.390
Sodium/Proton exchangers	R-HSA-425986	4.071133e-01	0.390
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.071133e-01	0.390
Cilium Assembly	R-HSA-5617833	4.080050e-01	0.389
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.114586e-01	0.386
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.169715e-01	0.380
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.169715e-01	0.380
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.169715e-01	0.380
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.239868e-01	0.373
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.239868e-01	0.373
Disease	R-HSA-1643685	4.241739e-01	0.372
Protein localization	R-HSA-9609507	4.247969e-01	0.372
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.331524e-01	0.363
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.331524e-01	0.363
HDMs demethylate histones	R-HSA-3214842	4.331524e-01	0.363
Hyaluronan degradation	R-HSA-2160916	4.331524e-01	0.363
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	4.331524e-01	0.363
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	4.346400e-01	0.362
ARMS-mediated activation	R-HSA-170984	4.346400e-01	0.362
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.346400e-01	0.362
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	4.346400e-01	0.362
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.346400e-01	0.362
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.346400e-01	0.362
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.346400e-01	0.362
MAPK1 (ERK2) activation	R-HSA-112411	4.346400e-01	0.362
Regulation of CDH11 gene transcription	R-HSA-9762293	4.346400e-01	0.362
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.346400e-01	0.362
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.346400e-01	0.362
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.349517e-01	0.362
Defective pyroptosis	R-HSA-9710421	4.364217e-01	0.360
Ion transport by P-type ATPases	R-HSA-936837	4.463202e-01	0.350
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.490890e-01	0.348
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.490890e-01	0.348
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.490890e-01	0.348
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.571655e-01	0.340
MET activates RAP1 and RAC1	R-HSA-8875555	4.608903e-01	0.336
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.608903e-01	0.336
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.608903e-01	0.336
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.608903e-01	0.336
Interleukin-27 signaling	R-HSA-9020956	4.608903e-01	0.336
MAPK3 (ERK1) activation	R-HSA-110056	4.608903e-01	0.336
Metal sequestration by antimicrobial proteins	R-HSA-6799990	4.608903e-01	0.336
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.608903e-01	0.336
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.609766e-01	0.336
Post-translational protein modification	R-HSA-597592	4.613796e-01	0.336
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.647693e-01	0.333
EPHA-mediated growth cone collapse	R-HSA-3928663	4.647693e-01	0.333
RNA Polymerase I Transcription Termination	R-HSA-73863	4.647693e-01	0.333
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.647693e-01	0.333
Opioid Signalling	R-HSA-111885	4.650604e-01	0.332
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.730803e-01	0.325
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.730803e-01	0.325
Diseases of DNA repair	R-HSA-9675135	4.730803e-01	0.325
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.766133e-01	0.322
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.801826e-01	0.319
Formation of the Early Elongation Complex	R-HSA-113418	4.801826e-01	0.319
Telomere Extension By Telomerase	R-HSA-171319	4.801826e-01	0.319
Phase 0 - rapid depolarisation	R-HSA-5576892	4.801826e-01	0.319
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.801826e-01	0.319
Inflammasomes	R-HSA-622312	4.801826e-01	0.319
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.850582e-01	0.314
vRNP Assembly	R-HSA-192905	4.859233e-01	0.313
Synthesis of PI	R-HSA-1483226	4.859233e-01	0.313
Bicarbonate transporters	R-HSA-425381	4.859233e-01	0.313
PECAM1 interactions	R-HSA-210990	4.859233e-01	0.313
Suppression of apoptosis	R-HSA-9635465	4.859233e-01	0.313
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.859233e-01	0.313
Interleukin-2 signaling	R-HSA-9020558	4.859233e-01	0.313
Dissolution of Fibrin Clot	R-HSA-75205	4.859233e-01	0.313
Transcription of the HIV genome	R-HSA-167172	4.873207e-01	0.312
mRNA Capping	R-HSA-72086	4.953200e-01	0.305
NGF-stimulated transcription	R-HSA-9031628	4.969038e-01	0.304
Metal ion SLC transporters	R-HSA-425410	4.969038e-01	0.304
Co-stimulation by CD28	R-HSA-389356	4.969038e-01	0.304
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.973808e-01	0.303
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.975377e-01	0.303
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.975377e-01	0.303
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.975377e-01	0.303
FCERI mediated NF-kB activation	R-HSA-2871837	5.043826e-01	0.297
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.097953e-01	0.293
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.097953e-01	0.293
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.097953e-01	0.293
Signaling by GSK3beta mutants	R-HSA-5339716	5.097953e-01	0.293
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.097953e-01	0.293
Plasmalogen biosynthesis	R-HSA-75896	5.097953e-01	0.293
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.097953e-01	0.293
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.097953e-01	0.293
Activation of RAC1	R-HSA-428540	5.097953e-01	0.293
Sodium/Calcium exchangers	R-HSA-425561	5.097953e-01	0.293
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.101738e-01	0.292
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.101738e-01	0.292
GABA synthesis, release, reuptake and degradation	R-HSA-888590	5.101738e-01	0.292
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.101738e-01	0.292
Interleukin-37 signaling	R-HSA-9008059	5.101738e-01	0.292
SLC transporter disorders	R-HSA-5619102	5.168173e-01	0.287
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.196241e-01	0.284
Meiotic recombination	R-HSA-912446	5.315869e-01	0.274
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	5.325098e-01	0.274
Late SARS-CoV-2 Infection Events	R-HSA-9772573	5.325098e-01	0.274
MET activates RAS signaling	R-HSA-8851805	5.325602e-01	0.274
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.325602e-01	0.274
Scavenging by Class F Receptors	R-HSA-3000484	5.325602e-01	0.274
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.325602e-01	0.274
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.325602e-01	0.274
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.325602e-01	0.274
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.325602e-01	0.274
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	5.325602e-01	0.274
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	5.325602e-01	0.274
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.325602e-01	0.274
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.325602e-01	0.274
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.325602e-01	0.274
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.325602e-01	0.274
Polymerase switching	R-HSA-69091	5.325602e-01	0.274
Leading Strand Synthesis	R-HSA-69109	5.325602e-01	0.274
Maple Syrup Urine Disease	R-HSA-9865114	5.325602e-01	0.274
Pervasive developmental disorders	R-HSA-9005895	5.325602e-01	0.274
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.325602e-01	0.274
Disorders of Nervous System Development	R-HSA-9697154	5.325602e-01	0.274
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	5.325602e-01	0.274
Interleukin-35 Signalling	R-HSA-8984722	5.325602e-01	0.274
Interleukin-15 signaling	R-HSA-8983432	5.325602e-01	0.274
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.325602e-01	0.274
OAS antiviral response	R-HSA-8983711	5.325602e-01	0.274
Negative regulation of the PI3K/AKT network	R-HSA-199418	5.341497e-01	0.272
Ca2+ pathway	R-HSA-4086398	5.367264e-01	0.270
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.367264e-01	0.270
Diseases of carbohydrate metabolism	R-HSA-5663084	5.367264e-01	0.270
DNA strand elongation	R-HSA-69190	5.390068e-01	0.268
tRNA processing	R-HSA-72306	5.423095e-01	0.266
mRNA 3'-end processing	R-HSA-72187	5.428461e-01	0.265
G-protein beta:gamma signalling	R-HSA-397795	5.529769e-01	0.257
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.529769e-01	0.257
Cardiogenesis	R-HSA-9733709	5.529769e-01	0.257
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	5.529769e-01	0.257
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.542692e-01	0.256
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.542692e-01	0.256
Interleukin-6 signaling	R-HSA-1059683	5.542692e-01	0.256
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	5.542692e-01	0.256
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.542692e-01	0.256
Reversible hydration of carbon dioxide	R-HSA-1475029	5.542692e-01	0.256
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.542692e-01	0.256
CD28 dependent Vav1 pathway	R-HSA-389359	5.542692e-01	0.256
Maturation of nucleoprotein	R-HSA-9683610	5.542692e-01	0.256
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.542692e-01	0.256
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	5.558089e-01	0.255
Effects of PIP2 hydrolysis	R-HSA-114508	5.666450e-01	0.247
Glutamate and glutamine metabolism	R-HSA-8964539	5.666450e-01	0.247
Miscellaneous transport and binding events	R-HSA-5223345	5.666450e-01	0.247
Removal of the Flap Intermediate	R-HSA-69166	5.749712e-01	0.240
Retrograde neurotrophin signalling	R-HSA-177504	5.749712e-01	0.240
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.749712e-01	0.240
CRMPs in Sema3A signaling	R-HSA-399956	5.749712e-01	0.240
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.749712e-01	0.240
Hydrolysis of LPC	R-HSA-1483115	5.749712e-01	0.240
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.749712e-01	0.240
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	5.749712e-01	0.240
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	5.749712e-01	0.240
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	5.749712e-01	0.240
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.749712e-01	0.240
Respiratory syncytial virus genome transcription	R-HSA-9828642	5.749712e-01	0.240
Zinc transporters	R-HSA-435354	5.749712e-01	0.240
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.749712e-01	0.240
G alpha (z) signalling events	R-HSA-418597	5.756590e-01	0.240
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.800090e-01	0.237
Signal amplification	R-HSA-392518	5.800090e-01	0.237
Hyaluronan metabolism	R-HSA-2142845	5.800090e-01	0.237
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.800090e-01	0.237
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.862639e-01	0.232
Signalling to ERKs	R-HSA-187687	5.930678e-01	0.227
Beta-catenin phosphorylation cascade	R-HSA-196299	5.947130e-01	0.226
G beta:gamma signalling through BTK	R-HSA-8964315	5.947130e-01	0.226
RNA Polymerase III Chain Elongation	R-HSA-73780	5.947130e-01	0.226
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.947130e-01	0.226
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.947130e-01	0.226
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.947130e-01	0.226
p38MAPK events	R-HSA-171007	5.947130e-01	0.226
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.947130e-01	0.226
DCC mediated attractive signaling	R-HSA-418885	5.947130e-01	0.226
p75 NTR receptor-mediated signalling	R-HSA-193704	5.988861e-01	0.223
Hemostasis	R-HSA-109582	6.049143e-01	0.218
GPVI-mediated activation cascade	R-HSA-114604	6.058208e-01	0.218
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.135389e-01	0.212
Phosphorylation of the APC/C	R-HSA-176412	6.135389e-01	0.212
Prolonged ERK activation events	R-HSA-169893	6.135389e-01	0.212
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.135389e-01	0.212
Fructose catabolism	R-HSA-70350	6.135389e-01	0.212
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.135389e-01	0.212
Activation of SMO	R-HSA-5635838	6.135389e-01	0.212
Attachment and Entry	R-HSA-9678110	6.135389e-01	0.212
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	6.170440e-01	0.210
Infection with Mycobacterium tuberculosis	R-HSA-9635486	6.191282e-01	0.208
RAB geranylgeranylation	R-HSA-8873719	6.269529e-01	0.203
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.314914e-01	0.200
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.314914e-01	0.200
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.314914e-01	0.200
Biosynthesis of maresin-like SPMs	R-HSA-9027307	6.314914e-01	0.200
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	6.314914e-01	0.200
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.314914e-01	0.200
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	6.314914e-01	0.200
Disorders of Developmental Biology	R-HSA-9675151	6.314914e-01	0.200
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.331168e-01	0.199
RNA Polymerase II Transcription Termination	R-HSA-73856	6.366840e-01	0.196
Formation of the cornified envelope	R-HSA-6809371	6.399970e-01	0.194
Transcriptional Regulation by E2F6	R-HSA-8953750	6.422505e-01	0.192
Signaling by Nuclear Receptors	R-HSA-9006931	6.442905e-01	0.191
Meiosis	R-HSA-1500620	6.444135e-01	0.191
Mitochondrial protein import	R-HSA-1268020	6.462365e-01	0.190
Heme signaling	R-HSA-9707616	6.462365e-01	0.190
Transcriptional regulation of granulopoiesis	R-HSA-9616222	6.462365e-01	0.190
PI3K events in ERBB2 signaling	R-HSA-1963642	6.486110e-01	0.188
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.486110e-01	0.188
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.486110e-01	0.188
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.486110e-01	0.188
Regulation of NPAS4 gene expression	R-HSA-9768759	6.486110e-01	0.188
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.486110e-01	0.188
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.486110e-01	0.188
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.537887e-01	0.185
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.537887e-01	0.185
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.537887e-01	0.185
Diseases of Immune System	R-HSA-5260271	6.537887e-01	0.185
Interleukin-2 family signaling	R-HSA-451927	6.537887e-01	0.185
Platelet homeostasis	R-HSA-418346	6.596198e-01	0.181
RNA Polymerase III Transcription Termination	R-HSA-73980	6.649363e-01	0.177
G beta:gamma signalling through PLC beta	R-HSA-418217	6.649363e-01	0.177
Polo-like kinase mediated events	R-HSA-156711	6.649363e-01	0.177
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.649363e-01	0.177
Presynaptic function of Kainate receptors	R-HSA-500657	6.649363e-01	0.177
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.649363e-01	0.177
Platelet sensitization by LDL	R-HSA-432142	6.649363e-01	0.177
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.649363e-01	0.177
Transcriptional Regulation by VENTX	R-HSA-8853884	6.650281e-01	0.177
Signaling by NTRKs	R-HSA-166520	6.737460e-01	0.172
Gastrulation	R-HSA-9758941	6.797024e-01	0.168
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.805041e-01	0.167
E2F mediated regulation of DNA replication	R-HSA-113510	6.805041e-01	0.167
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.805041e-01	0.167
Specification of the neural plate border	R-HSA-9834899	6.805041e-01	0.167
STING mediated induction of host immune responses	R-HSA-1834941	6.805041e-01	0.167
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.805041e-01	0.167
Rap1 signalling	R-HSA-392517	6.805041e-01	0.167
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.805041e-01	0.167
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.805041e-01	0.167
Maturation of nucleoprotein	R-HSA-9694631	6.805041e-01	0.167
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	6.805041e-01	0.167
Other interleukin signaling	R-HSA-449836	6.805041e-01	0.167
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.805041e-01	0.167
Cytosolic tRNA aminoacylation	R-HSA-379716	6.866221e-01	0.163
Kidney development	R-HSA-9830369	6.913048e-01	0.160
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.953494e-01	0.158
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.953494e-01	0.158
Melanin biosynthesis	R-HSA-5662702	6.953494e-01	0.158
Wax and plasmalogen biosynthesis	R-HSA-8848584	6.953494e-01	0.158
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.953494e-01	0.158
Acyl chain remodelling of PI	R-HSA-1482922	6.953494e-01	0.158
Creatine metabolism	R-HSA-71288	6.953494e-01	0.158
Formation of definitive endoderm	R-HSA-9823730	6.953494e-01	0.158
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.953494e-01	0.158
Pregnenolone biosynthesis	R-HSA-196108	6.953494e-01	0.158
Nephrin family interactions	R-HSA-373753	6.953494e-01	0.158
Adipogenesis	R-HSA-9843745	6.983444e-01	0.156
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.997805e-01	0.155
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.997805e-01	0.155
Death Receptor Signaling	R-HSA-73887	7.084422e-01	0.150
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.095058e-01	0.149
G-protein activation	R-HSA-202040	7.095058e-01	0.149
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.095058e-01	0.149
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.095058e-01	0.149
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.095058e-01	0.149
Phenylalanine metabolism	R-HSA-8964208	7.095058e-01	0.149
ERK/MAPK targets	R-HSA-198753	7.095058e-01	0.149
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	7.095058e-01	0.149
Zygotic genome activation (ZGA)	R-HSA-9819196	7.095058e-01	0.149
Acyl chain remodelling of PG	R-HSA-1482925	7.095058e-01	0.149
Signalling to RAS	R-HSA-167044	7.095058e-01	0.149
Early Phase of HIV Life Cycle	R-HSA-162594	7.095058e-01	0.149
Neuronal System	R-HSA-112316	7.098537e-01	0.149
Attachment and Entry	R-HSA-9694614	7.230053e-01	0.141
Signaling by PDGFR in disease	R-HSA-9671555	7.230053e-01	0.141
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.263727e-01	0.139
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.274536e-01	0.138
Collagen formation	R-HSA-1474290	7.274536e-01	0.138
Mitochondrial protein degradation	R-HSA-9837999	7.274536e-01	0.138
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.358782e-01	0.133
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.358782e-01	0.133
WNT ligand biogenesis and trafficking	R-HSA-3238698	7.358782e-01	0.133
RAF-independent MAPK1/3 activation	R-HSA-112409	7.358782e-01	0.133
LDL clearance	R-HSA-8964038	7.358782e-01	0.133
Ethanol oxidation	R-HSA-71384	7.358782e-01	0.133
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.474036e-01	0.126
Interleukin receptor SHC signaling	R-HSA-912526	7.481535e-01	0.126
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.481535e-01	0.126
Interleukin-20 family signaling	R-HSA-8854691	7.481535e-01	0.126
Biosynthesis of maresins	R-HSA-9018682	7.481535e-01	0.126
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	7.481535e-01	0.126
CYP2E1 reactions	R-HSA-211999	7.598591e-01	0.119
Thromboxane signalling through TP receptor	R-HSA-428930	7.598591e-01	0.119
Interleukin-6 family signaling	R-HSA-6783589	7.598591e-01	0.119
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.598591e-01	0.119
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.598591e-01	0.119
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.598591e-01	0.119
Complex III assembly	R-HSA-9865881	7.598591e-01	0.119
Azathioprine ADME	R-HSA-9748787	7.617706e-01	0.118
The phototransduction cascade	R-HSA-2514856	7.699761e-01	0.114
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.710213e-01	0.113
G protein gated Potassium channels	R-HSA-1296059	7.710213e-01	0.113
Activation of G protein gated Potassium channels	R-HSA-1296041	7.710213e-01	0.113
Acyl chain remodelling of PS	R-HSA-1482801	7.710213e-01	0.113
Interleukin-7 signaling	R-HSA-1266695	7.710213e-01	0.113
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.710213e-01	0.113
Formation of the nephric duct	R-HSA-9830364	7.710213e-01	0.113
Laminin interactions	R-HSA-3000157	7.710213e-01	0.113
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.710213e-01	0.113
Integrin cell surface interactions	R-HSA-216083	7.749523e-01	0.111
Neurexins and neuroligins	R-HSA-6794361	7.779343e-01	0.109
Extra-nuclear estrogen signaling	R-HSA-9009391	7.781421e-01	0.109
Asparagine N-linked glycosylation	R-HSA-446203	7.795187e-01	0.108
Sensory processing of sound	R-HSA-9659379	7.815458e-01	0.107
MET activates PTK2 signaling	R-HSA-8874081	7.816653e-01	0.107
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.816653e-01	0.107
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.816653e-01	0.107
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.816653e-01	0.107
TRP channels	R-HSA-3295583	7.816653e-01	0.107
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.816653e-01	0.107
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.816653e-01	0.107
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.816653e-01	0.107
Amino acids regulate mTORC1	R-HSA-9639288	7.856504e-01	0.105
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	7.918151e-01	0.101
Activation of HOX genes during differentiation	R-HSA-5619507	8.005415e-01	0.097
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.005415e-01	0.097
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.014937e-01	0.096
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.014937e-01	0.096
Cytoprotection by HMOX1	R-HSA-9707564	8.063410e-01	0.093
Glucagon-type ligand receptors	R-HSA-420092	8.107229e-01	0.091
Signaling by Erythropoietin	R-HSA-9006335	8.107229e-01	0.091
Synthesis of PA	R-HSA-1483166	8.142004e-01	0.089
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.142004e-01	0.089
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.195235e-01	0.086
Activation of the pre-replicative complex	R-HSA-68962	8.195235e-01	0.086
DAP12 signaling	R-HSA-2424491	8.195235e-01	0.086
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.195235e-01	0.086
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.195235e-01	0.086
Neurotransmitter clearance	R-HSA-112311	8.195235e-01	0.086
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.207859e-01	0.086
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.207859e-01	0.086
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.233453e-01	0.084
Cardiac conduction	R-HSA-5576891	8.267514e-01	0.083
Molecules associated with elastic fibres	R-HSA-2129379	8.279155e-01	0.082
Downstream signal transduction	R-HSA-186763	8.279155e-01	0.082
tRNA Aminoacylation	R-HSA-379724	8.333320e-01	0.079
Inwardly rectifying K+ channels	R-HSA-1296065	8.359177e-01	0.078
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.359177e-01	0.078
Signaling by WNT in cancer	R-HSA-4791275	8.359177e-01	0.078
Collagen degradation	R-HSA-1442490	8.393031e-01	0.076
Nuclear RNA decay	R-HSA-9930044	8.435482e-01	0.074
FGFR1 mutant receptor activation	R-HSA-1839124	8.435482e-01	0.074
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.435482e-01	0.074
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.450798e-01	0.073
Signaling by PDGF	R-HSA-186797	8.450798e-01	0.073
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.506673e-01	0.070
Acyl chain remodelling of PC	R-HSA-1482788	8.508244e-01	0.070
Glucagon signaling in metabolic regulation	R-HSA-163359	8.508244e-01	0.070
eNOS activation	R-HSA-203615	8.577626e-01	0.067
RA biosynthesis pathway	R-HSA-5365859	8.577626e-01	0.067
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.577626e-01	0.067
Transferrin endocytosis and recycling	R-HSA-917977	8.643784e-01	0.063
Acyl chain remodelling of PE	R-HSA-1482839	8.643784e-01	0.063
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	8.643784e-01	0.063
tRNA modification in the nucleus and cytosol	R-HSA-6782315	8.663451e-01	0.062
Rab regulation of trafficking	R-HSA-9007101	8.686902e-01	0.061
RET signaling	R-HSA-8853659	8.706870e-01	0.060
Lysosome Vesicle Biogenesis	R-HSA-432720	8.706870e-01	0.060
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.706870e-01	0.060
FGFR2 mutant receptor activation	R-HSA-1839126	8.706870e-01	0.060
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.759425e-01	0.058
Phenylalanine and tyrosine metabolism	R-HSA-8963691	8.767024e-01	0.057
Collagen chain trimerization	R-HSA-8948216	8.767024e-01	0.057
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.824384e-01	0.054
Elastic fibre formation	R-HSA-1566948	8.824384e-01	0.054
COPII-mediated vesicle transport	R-HSA-204005	8.849009e-01	0.053
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.879079e-01	0.052
Post-translational protein phosphorylation	R-HSA-8957275	8.903927e-01	0.050
Regulation of insulin secretion	R-HSA-422356	8.903927e-01	0.050
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.931232e-01	0.049
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	8.931232e-01	0.049
Mitochondrial tRNA aminoacylation	R-HSA-379726	8.931232e-01	0.049
Signaling by FGFR in disease	R-HSA-1226099	9.010469e-01	0.045
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.028380e-01	0.044
HIV Transcription Initiation	R-HSA-167161	9.028380e-01	0.044
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.028380e-01	0.044
Intra-Golgi traffic	R-HSA-6811438	9.028380e-01	0.044
Scavenging by Class A Receptors	R-HSA-3000480	9.028380e-01	0.044
Signaling by FGFR1 in disease	R-HSA-5655302	9.028380e-01	0.044
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.028380e-01	0.044
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.028380e-01	0.044
PI Metabolism	R-HSA-1483255	9.039254e-01	0.044
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.058321e-01	0.043
Parasitic Infection Pathways	R-HSA-9824443	9.061507e-01	0.043
Leishmania infection	R-HSA-9658195	9.061507e-01	0.043
Activation of GABAB receptors	R-HSA-991365	9.073595e-01	0.042
GABA B receptor activation	R-HSA-977444	9.073595e-01	0.042
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.073595e-01	0.042
RNA Polymerase II Promoter Escape	R-HSA-73776	9.116709e-01	0.040
Pyrimidine catabolism	R-HSA-73621	9.116709e-01	0.040
Signaling by SCF-KIT	R-HSA-1433557	9.116709e-01	0.040
TBC/RABGAPs	R-HSA-8854214	9.116709e-01	0.040
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.117424e-01	0.040
DAP12 interactions	R-HSA-2172127	9.157818e-01	0.038
Methylation	R-HSA-156581	9.157818e-01	0.038
Amine ligand-binding receptors	R-HSA-375280	9.157818e-01	0.038
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.157818e-01	0.038
Netrin-1 signaling	R-HSA-373752	9.157818e-01	0.038
Reproduction	R-HSA-1474165	9.158011e-01	0.038
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.182603e-01	0.037
Metabolism of nucleotides	R-HSA-15869	9.190035e-01	0.037
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.197017e-01	0.036
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.197017e-01	0.036
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.197017e-01	0.036
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.197017e-01	0.036
Bacterial Infection Pathways	R-HSA-9824439	9.225527e-01	0.035
Signaling by TGFBR3	R-HSA-9839373	9.234393e-01	0.035
GPER1 signaling	R-HSA-9634597	9.304014e-01	0.031
Integration of energy metabolism	R-HSA-163685	9.321076e-01	0.031
Protein-protein interactions at synapses	R-HSA-6794362	9.352003e-01	0.029
PI3K Cascade	R-HSA-109704	9.367311e-01	0.028
Signaling by FGFR2 in disease	R-HSA-5655253	9.367311e-01	0.028
Complex IV assembly	R-HSA-9864848	9.396770e-01	0.027
Branched-chain amino acid catabolism	R-HSA-70895	9.396770e-01	0.027
Leishmania phagocytosis	R-HSA-9664417	9.400890e-01	0.027
Parasite infection	R-HSA-9664407	9.400890e-01	0.027
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.400890e-01	0.027
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.401967e-01	0.027
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.424858e-01	0.026
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.441962e-01	0.025
Neurotransmitter release cycle	R-HSA-112310	9.487771e-01	0.023
Paracetamol ADME	R-HSA-9753281	9.501527e-01	0.022
Dectin-2 family	R-HSA-5621480	9.546880e-01	0.020
IRS-mediated signalling	R-HSA-112399	9.546880e-01	0.020
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.559493e-01	0.020
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.562724e-01	0.019
Keratinization	R-HSA-6805567	9.571708e-01	0.019
GABA receptor activation	R-HSA-977443	9.607300e-01	0.017
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.607300e-01	0.017
Signaling by Retinoic Acid	R-HSA-5362517	9.607300e-01	0.017
Aquaporin-mediated transport	R-HSA-445717	9.625596e-01	0.017
IRS-related events triggered by IGF1R	R-HSA-2428928	9.625596e-01	0.017
Potassium Channels	R-HSA-1296071	9.627115e-01	0.017
PPARA activates gene expression	R-HSA-1989781	9.641663e-01	0.016
Complex I biogenesis	R-HSA-6799198	9.659672e-01	0.015
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.664445e-01	0.015
Synthesis of bile acids and bile salts	R-HSA-192105	9.669329e-01	0.015
Xenobiotics	R-HSA-211981	9.675531e-01	0.014
IGF1R signaling cascade	R-HSA-2428924	9.675531e-01	0.014
Insulin receptor signalling cascade	R-HSA-74751	9.675531e-01	0.014
Interferon gamma signaling	R-HSA-877300	9.685872e-01	0.014
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.690652e-01	0.014
Degradation of the extracellular matrix	R-HSA-1474228	9.715527e-01	0.013
Metabolism of steroid hormones	R-HSA-196071	9.718814e-01	0.012
ECM proteoglycans	R-HSA-3000178	9.767689e-01	0.010
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.767689e-01	0.010
Metabolism of cofactors	R-HSA-8978934	9.767689e-01	0.010
Purine catabolism	R-HSA-74259	9.778520e-01	0.010
Aspirin ADME	R-HSA-9749641	9.788846e-01	0.009
Bile acid and bile salt metabolism	R-HSA-194068	9.796583e-01	0.009
Citric acid cycle (TCA cycle)	R-HSA-71403	9.808078e-01	0.008
Leishmania parasite growth and survival	R-HSA-9664433	9.810228e-01	0.008
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.810228e-01	0.008
FCERI mediated MAPK activation	R-HSA-2871796	9.812549e-01	0.008
Interleukin-10 signaling	R-HSA-6783783	9.833696e-01	0.007
G alpha (12/13) signalling events	R-HSA-416482	9.833696e-01	0.007
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.841452e-01	0.007
Role of phospholipids in phagocytosis	R-HSA-2029485	9.847327e-01	0.007
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.855898e-01	0.006
Sulfur amino acid metabolism	R-HSA-1614635	9.891815e-01	0.005
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.907142e-01	0.004
Transport of small molecules	R-HSA-382551	9.910277e-01	0.004
Class B/2 (Secretin family receptors)	R-HSA-373080	9.910641e-01	0.004
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.917957e-01	0.004
Nucleotide catabolism	R-HSA-8956319	9.918074e-01	0.004
Signaling by Insulin receptor	R-HSA-74752	9.922580e-01	0.003
Phospholipid metabolism	R-HSA-1483257	9.926229e-01	0.003
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.932925e-01	0.003
Glycerophospholipid biosynthesis	R-HSA-1483206	9.933603e-01	0.003
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.939043e-01	0.003
G alpha (s) signalling events	R-HSA-418555	9.940991e-01	0.003
FOXO-mediated transcription	R-HSA-9614085	9.947191e-01	0.002
Diseases of glycosylation	R-HSA-3781865	9.964394e-01	0.002
Visual phototransduction	R-HSA-2187338	9.966230e-01	0.001
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.970282e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.971651e-01	0.001
Arachidonate metabolism	R-HSA-2142753	9.972714e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.980673e-01	0.001
Regulation of Complement cascade	R-HSA-977606	9.986826e-01	0.001
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.991022e-01	0.000
Drug ADME	R-HSA-9748784	9.991161e-01	0.000
Respiratory electron transport	R-HSA-611105	9.991477e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.991847e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.992358e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.993395e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.994497e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.995413e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.995570e-01	0.000
Complement cascade	R-HSA-166658	9.995833e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.995922e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.997225e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.997658e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.998551e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999257e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999446e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999731e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999959e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999997e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999998e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000